text:
Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity
This study has been terminated.
(The enrollment rate at most centers was unlikely to result in the recruitment of the planned sample size of 40 evaluable subjects.)
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: February 16, 2009
Last updated: November 28, 2014
Last verified: November 2014
|Tracking Information
|First Received Date ICMJE
|February 16, 2009
|Last Updated Date
|November 28, 2014
|Start Date ICMJE
|February 2007
|Primary Completion Date
|October 2007 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Change from baseline in volume at first detrusor contraction as determined by urodynamics [ Time Frame: At week 4 ]
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Complete list of historical versions of study NCT00845338 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Same as current
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity
|Official Title ICMJE
|A 4-week, Open-label, Multicenter, Urodynamic Pilot Study to Explore the Efficacy, Tolerability and Safety of Darifenacin (7.5 mg With Up-titration to 15 mg) in Patients With Multiple Sclerosis and Neurogenic Detrusor Overactivity
|Brief Summary
|The objective of this study is to explore the effects of darifenacin in patients with multiple sclerosis and neurogenic detrusor overactivity. The efficacy, safety and tolerability of darifenacin are already well established in idiopathic detrusor overactivity. Patients with multiple sclerosis and neurogenic detrusor overactivity without detrusor-sphincter-dyssynergia (DSD) will be allocated to darifenacin therapy.
|Detailed Description
|Not Provided
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Condition ICMJE
|Intervention ICMJE
|Drug: Darifenacin (BAY79-4998)
Darifenacin 7,5mg tablets once daily for 14 days, darifenacin 7,5mg or 15mg once daily for 14 consecutive days
|Study Arms
|Experimental: Arm 1
Intervention: Drug: Darifenacin (BAY79-4998)
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Completion Date
|October 2007
|Primary Completion Date
|October 2007 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
2006-002361-39 ( EudraCT Number )
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Study Sponsor ICMJE
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|Verification Date
|November 2014
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


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belly laugh
Definition of belly laugh
: a deep hearty laugh
Examples of belly laugh in a Sentence
He has an infectious belly laugh.
The show provided lots of belly laughs.
First Known Use of belly laugh
BELLY LAUGH Defined for English Language Learners
belly laugh
Definition of belly laugh for English Language Learners
: a deep and loud laugh
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I've just read the amazing story of Martha Mullen, who arranged for the body of the elder Boston bomber brother's body to be buried in Doswell, Virginia. It's a courageous act, after all the controversy that burying Tamerlan Tsarnaev has created. [Read more…]
There Are No Enemies
May 11, 2013 by Leave a Comment


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Characterization of blood biochemical markers during aging in the Grey Mouse Lemur (Microcebus murinus): impact of gender and season
BMC Veterinary Research 2012, 8:211 doi:10.1186/1746-6148-8-211
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Stan Lee revived for a new audience
I can see from this animated movie Stan Lee is ensuring a new breed of super hero audience is being engaged to keep this form of entertainment alive and kicking. Not written as an adult-gauged story, but more for current youth to experience the genre of animated entertainment targetting the topic of a normal person becoming empowered with abilities beyond the norm. Scott Lobdell, known for writing about character development in his comic stories during the Uncanny X-Men days, definitely was true to form in putting much focus on the main character changing from a young actress to a hero. Young family members 15 and under will probably appreciate this more, as this is not written to present Stan Lee's old work or something even close to this as times have changed - so has Stan's storytelling to adjust with the times.
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With its reputation as the mild-mannered, tea-sipping "most British city in Canada," who knew that Victoria was secretly a hotbed of laminaria-loving algae aficionados? Thanks to the cold, clean waters around Vancouver Island, Victoria is home to some of the world's purest seaweed, a superfood that offers an incredible range of minerals, vitamins and iron.
But forget about that seaweed you see washed up on the beach; that's basically compost. The good stuff is to be found in the ocean and can only be harvested in seaweed season, which runs from May till September. Although seaweeds don't have roots, they still cling tenaciously to rocks through a "holdfast," which lets them grow upwards, absorbing all those nutrients direct from the sea, just as they've been doing for 800 million years. Seaweed starts growing on Dec. 21, when the planet is tilted away from the sun in the northern hemisphere and it begins reproducing after the spring equinox.
If you thought seaweed was only good for wrapping around a California roll, think again. Here are five ways to discover its many benefits.
Harvest it
Go straight to the source at the Western hemisphere's only Seaweed Centre in Sooke, and take a two-hour Wild Seaweed tour with "Seaweed lady" and Sea Flora beauty founder Diane Bernard. Head out at low tide and discover how to hand-harvest these ancient organisms in the pristine waters along the shoreline. From bobbly textured scarlet ribbons to sludge-green slimy fronds, more than 600 varieties grow here; learn to spot the difference between a sea lettuce and bull kelp like a pro. sea-flora.com
Brew it
The Silk Road Tea Co. is based in Victoria's small but perfectly formed Chinatown – the oldest in Canada with its roots in the mining boom of the 1850s – where tea master Daniela Cubelic creates internationally acclaimed blends from organic botanicals. Take a seat at the polished tasting bar and sample a pot of "Mermaid's Potion" to bring some seaweed sorcery into your life. Far from weedy, this is a fresh and minty brew with a sophisticated smoky aftertaste. silkroadteastore.com
Wallow in it
Not just a superfood; seaweed also has superbeauty powers. Get a seaweed spa fix to absorb those benefits. Lie back and think of the algae at the Oak Bay Beach spa when you book an organic seaweed facial to detox and soothe stressed skin. Or try the Hotel Magnolia's spa to experience a full-body seaweed therapy, which starts with a frond of seaweed smoothed down your spine and ends in a remineralizing massage. Bonus – you get to keep the "seaweed spine" and use it in the tub at home. Good for three soaks. oakbaybeachhotel.com or spamagnolia.com
Eat it
Raw, deep-fried, pickled, smoked or steamed – your seaweed comes in many forms at the Sooke Harbour House restaurant. Sometimes it's even baked into edible "plates" holding juicy just-caught crabmeat. The venturesome clientele here chomp their way through about 25 different kinds of seaweed during the season. Seaweed scaredy cats can start with the mild-flavoured seaweed-baked laverbread, but fans of the Sooke Harbour House's West Coast-only cuisine swear by the alaria seaweed mussel broth and laminaria-wrapped catch of the day. sookeharbourhouse.com
Drink it
Few of us would eye up a sunomono salad (Japanese shrimp salad) and see it as inspiration for a cocktail, but that is why we are not award-winning mixologists and Katie McDonald is. Head to the Veneto Tapa Lounge and give Katie's seaweed-garnished sunomono cocktail creation a whirl. With a deliciously tangy blend of vodka, shochu, honey and rice wine vinegar, with its very own kapa maki roll speared on the rim, salad never tasted so good. Warning: Testing the restorative powers of seaweed by trying to detox through excessive "retoxing" may cause undesired hangover-like effects. venetodining.com
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Monday September 7th, 2009 - 12:44AM
When it comes to having "cautious optimism," Noble Investment Group appears to have a lock on this attitude which is often brought into play during "we-know-it-will-get-better" times.
For the past 16 months, the privately held, Atlanta-based company has made a point of being ultra-conservative in its investment spending, sitting on approximately $206 million in its most recent of three funds. In fact, beginning in May of 2008—well before the markets imploded in the third quarter—the 16-year-old firm did not let loose one dollar for investment from Noble HospitalityFund, LLC, a tactic it touted to investors this past May when posting its first-quarter report.
And from where he sits as senior managing principal and CEO, Mitesh "Mit" Shah believes being frugal will now allow the company greater leeway in the months ahead to make some advantageous—perhaps even bold—moves.
"When we look forward we see the greatest opportunity to take advantage of the crisis in the marketplace that we've seen in our existence," Shah said. "My goal and the goal for this organization is to be in a position to take full advantage of the opportunities that come out of this crisis."
During the next 16 months Shah expects Noble to behave in a way that is the polar opposite of its recent conservatism. "We're going to be very active as it relates to making investments," he said.
Shah noted Noble invests capital on behalf of pension and other funds and university endowments with a time horizon of five to seven years. Of three funds it has raised, it has made 41 investments, 18 of which have been fully realized for a 32% internal rate of return (IRR) and more than a 3X equity multiple, according to the CEO. "Those numbers are eye catching and allow us to do things," he said.
Investment groups, however, have appreciated the company's tightness with the latest fund, which was closed in January 2007. "Two years and eight months later, the fact that we've invested less than a third [$104.9 million is committed] of that fund is very, very comforting to our investors," Shah said, adding some of the investors have been players in problem-plagued, billion-dollar "behemoth" funds.
It's not that Noble hasn't been keeping tabs on the marketplace, but even when presented with what seemed an ideal deal last year, Noble paused and eventually punted. "There was an asset in a top 20 [metropolitan statistical area] that we had looked at for three years that we really liked. The price that we were able to negotiate was based on a 10 cap on 2009 forecasted numbers; this is back in December," Shah explained. "In January we put it under contract with a very quick closing timeline based on what we all collectively forecasted as a 10% reduction in RevPAR for 2009 and a corresponding 18% reduction in [net operating income] and a 10 cap on that number. That number represented a 35% discount in price…so that was pretty significant for us. But then, what happened that first week of January—20% down RevPAR [for three weeks]. So the question everyone was asking was: blip or trend? We terminated the contract because we did not know if this was a blip or trend. We really felt it was more likely a trend…and it turned out it wasn't a blip. That asset in today's terms is worth significantly less than for what we would have bought it."
The decision was a wise one not only for investors, but for Noble's principals as well since they co-invest their own capital along with investors into the equity funds.
Shah is no stranger to the type of economic turmoil that has kept the global financial community and the lodging industry twitching of late. Indeed, it was in 1993—another tumultuous time for hospitality—that Noble came into existence. Since then, he and his executive team have made it their mission to produce strong returns while remaining prudent investment managers [See sidebar].
So it's no coincidence that a sense of calm permeates Noble's headquarters in the Monarch Tower on Peachtree Road here. Soothing tan and beige tones play against dark woods in offices from where the low hum of activity emanates as executives and staff strategize, involving themselves in the firm's core competencies of investment management, property operations as well as development, re-development, conversions, design and construction.
In addition to its fiduciary role, Noble currently operates close to 9,000 guestrooms affiliated with Marriott, Hyatt, Starwood, Hilton and IHG brands; convention and conference centers representing more than a million square feet of meeting space; as well as day and resort spas, restaurants and branded retail coffee stores.
From his 11th floor office, Shah can look out over a portion of Atlanta's changing landscape, part of which Noble itself shaped when it converted two properties into W hotels for its own account in the Buckhead and Midtown neighborhoods.
The vantage point likely inspires visionary thoughts of what could lie ahead for Noble as 2009 and 2010 spool out. Shah, comfortably ensconced in a design-forward chair, willingly shares one avenue the firm is poised to go down.
Almost a year ago, Shah told HOTEL BUSINESS® there were a number of opportunities in the market that were not distressed but were what he termed "dislocated assets" that had debt coming due or that the investor thought 30% equity would be sufficient and now it's 50% or assets that needed to be sold to raise cash. "We're waiting for distressed," emphasized Shah at the time.
Shah now feels distressed is arriving. "The reality is setting in across the board that not only is 2009 not getting better—we're at 16% negative RevPAR (at press time), which is better than minus 20—so still down significantly…but the pundits are saying 2010 is going to be down," Shah said.
Continuing monetary defaults—commercial mortgage-backed securities as well as traditional banks—foreclosures and approaching maturities also are factors likely to force decisions on assets for many owners who previously thought they only had to get through the end of the year. "All of that coming together is going to create real distress," Shah said.
With expertise ranging from the limited-service sector to luxury and resort properties, Noble is well situated to choose among the opportunities Shah anticipates. However, the CEO noted there's been "a paradigm shift to thrift" among consumers that will find Noble "extremely focused" on the select-service sector. "It's an area that's performed unbelievably well for us when we've made investments," Shah said, citing investments into Hyatt Place, Courtyard by Marriott, Residence Inn by Marriott, Hilton Garden Inn. "Even an Aloft that we opened in January, new construction in Charlotte [NC], is producing double-digit cash on equity."
Noble also is setting its sights on distressed debt, "which is going to come in all shapes, sizes and formats," Shah said.
Toward that end, the company has formed Noble Lodging Advisors, which will provide resources to owners and lenders of distressed lodging assets. The strategic sourcing initiative, which will review potential investments for the remaining two-thirds of Fund III's equity, will allow Noble to stay ahead of the curve in assessing distressed property opportunities as it interacts with lodging lenders and institutions, many of which sought out Noble for guidance, Shah said. "We can partner with a lender to resize debt across a wide spectrum," Shah said. "In six to 12 months, the lenders are really going to be the equity on a number of different hotels, so what do they do? Do they sell the note at 40 cents on the dollar because that's probably what it's worth? Do they foreclose and just own the asset? Do they restructure the debt with the existing sponsor and does the sponsor have the wherewithal to get through? What they're looking for is how to create the opportunity to salvage what the value is on the debt side. So, we'll come in and say there's a $50 million loan and it's worth $30 million today. We'll put in $10 million in capital, [the lender] keeps $20 million in place, we'll resize at $30 million—don't sell it at $30 million, don't restructure at $30 million. We'll buy into it and give [the lender] a share of the upside. So now they can earn back up the food chain and that's very compelling for lenders and how they ride through."
Noble will work with a group of lenders who have been supportive of the organization during "up" times, Shah said. Discussions have begun with such institutions as GE Capital, CapMark, Anglo Irish, Principal, Wells Fargo, Deutsche Bank, Barclays and Merrill Lynch, among others.
"I never want to be perceived as this vulture that's stepping in, but what's going to happen is there's going to be a complete reset as it relates to a lot of these assets that are out there and lenders are going to have to come up with some decisions," Shah said.
While Shah suggested "distress knows no boundaries," right now he's seeing it primarily in the resort and luxury segments. It was less than two years ago that resorts loomed large in Noble's expansion plans, with the company looking to double its resort portfolio by 2011. "There was a unique opportunity on the public/private side to go in and get subsidies from residential developers that wanted to build residential communities around resorts," Shah recalled, noting there were several opportunities teed up at the time: Jekyll Island, GA; Swan Point, MD; and at Reunion and Hammock Beach in Florida. "We were going to get subsidies from the land owner and the residential developer to basically buy down 40% of the development costs of the hotel. Why would they do that? They needed the hotel and the resort component to drive the momentum so they could go sell real estate."
Noble would have built and owned only the hotel tower, but would have operated the entire resort, including the golf and spa.
The bulk of the deals were iced because of the fallout in the residential resort markets. However, both Reunion and Hammock Beach became the first opportunities for the expertise of Noble Lodging Advisors. "We've got two massive resorts there that represent the first wave of distress that is happening in our industry," Shah said.
Noble also is keeping busy with other things as it waits for those floodgates to open wider. It's preparing this fall to open the 220-room Macon Marriott City Center that it owns in Georgia and which is connected to the Macon Centreplex that includes a 100,000-square-foot convention center and a 9,250-seat coliseum, both of which Noble will operate. Shah noted with the city subsidy into the asset "we're building a full-service Marriott for just a little over $100,000 a room all in."
Noble has a handful of similar properties with extensive meeting space and despite industry-wide declines in group demand, Shah remains confident in the model.
"Even in these kinds of times, state associations and small groups travel," he said, noting traveling to the Macon Marriott does not carry the so-called "AIG effect" of perceived extravagance.
Shah acknowledged less group demand is of concern in the near term. "That's a reality, but because of the economic model we have structured in each of our convention center situations we have the ability to ride out certain downturns because of the cost-sharing model," he said, adding the properties also are open to renegotiating existing group meeting contracts. "I also like the idea that in a property like Macon that we only have to sell 110 rooms on average a night at the rate the [local] Courtyard is getting right now to make money based on the way [the city and Noble are] sharing expenses."
Noble also is involved in mixed-use development with projects that include the 244-room Hyatt Regency Valencia, which is part of the Valencia Town Center in Valencia, CA, a one-million-square-foot, mixed-use development. The hotel, which Noble is operating, also encompasses the 16,000-square-foot Santa Clarita Conference Center. Another development is the Aloft Charlotte Uptown, which is part of a vertically integrated project with office and retail components in the city's new $275-million Epicenter complex.
Shah felt MUDs reflect the new lifestyles that consumers and travelers are embracing, where office, retail, entertainment, dining and lodging may all be accessed easily in one destination. In the current marketplace, however, and despite numerous opportunities, Shah said building in such scenarios is not as compelling right now as acquiring.
With the amount of success the organization has had, investing more than $1 billion in the lodging sector since its inception, Shah was asked if there was any consideration of taking the company public. "We currently are focused on the private equity side of the business because we view that as the most efficient. We always pay attention to the public side because we've always believed the public side has been leading in terms of its thoughts and its perspectives. We believe the public side right now is gaining some real efficiencies in terms of the marketplace and also as it relates to lodging," he said. "When we look at our role and responsibilities, there are some platforms that we believe will continue to be best suited for private platforms and there are platforms that could be better suited for public platforms in our space."
Although it has business in many different buckets, such as three Starbucks coffee stores, four spas and several restaurants owned outright, in joint ventures or leased, including some that are currently experiencing significant slowdowns, Noble is well positioned to go forward in a variety of directions. But again, it shall remain prudent, Shah said.
"The reason why we're in different segments of the business, the reason why we've built competencies in those segments is because opportunities change over time," he explained. "We're always focused on opportunities but we're going to be extremely selective going forward."


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Gov. Jan Brewer, who signed SB 1070, recently said undocumented immigrants were all "drug mules."
He looked especially phony when talking about undocumented workers "self-deporting" and squirmed when asked about his tax returns.
Of course, most information about the undocumented is anecdotal, since this is a population that fears being counted.
Eighty-five percent of undocumented immigrants identified through Secure Communities last year were not deported.
Some of the undocumented immigrants who call themselves DREAMers have held sit-ins in Obama campaign offices.
How soon will you give all undocumented citizens (that have not commited crimes) legal residency?
His idea of generosity was the undocumented and unqualified purchase of a person by payments made in the form of a gift.
Surely it is safe here to domicile the restless Doctor, for these ten undocumented years between 1805 and 1815.
Already that undocumented Magna Charta was manifestly not working upon the lines she had anticipated.
The two specimens of this plate in the national collections are undocumented.


text:
Week 2 of the NFL season will kick off in a few more hours from Lambeau Field when the Green Bay Packers host the Chicago Bears.
While you wait for the league's longest rivalry to resume, here are some of the best highlights from Week 1:
Reid Cherner has been with USA TODAY since 1982 and written Game On! since March 2008.
He has covered everything from high schools to horse racing to the college and the pros. The only thing he likes more than his own voice is the sound of readers telling him when he's right and wrong.
Michael Hiestand has covered sports media and marketing for USA TODAY, tackling the sports biz ranging from what's behind mega-events such as the Olympics and Super Bowl to the sometimes-hidden numbers behind the sports world's bottom line.


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|Specific References
|Related Products
|Human Cells
|Human Cell lysate that Human Siglec-2 / CD22 (aa 176-687) transfected / overexpressed for Western blot (WB) positive control. The whole cell lysate is provided in 1X Sample Buffer (1X modified RIPA buffer+1X SDS loading buffer).
|A DNA sequence encoding the human CD22 (Q32M46) (Trp176-Arg687) was fused with a polyhistidine tag at the C-terminus.
|Trp 176
|The recombinant human CD22 consists of 523 amino acids and predictes a molecular mass of 58.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the recombinant protein is approximately 90-100 kDa due to glycosylation.
|Cell lysate was prepared by homogenization in ice-cold modified RIPA Lysis Buffer with cocktail of protease inhibitors (Sigma). Cell debris was removed by centrifugation. Protein concentration was determined by Bradford assay (Bio-Rad protein assay, Microplate Standard assay). The cell lysate was boiled for 5 min in 1 x SDS loading buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% b-mercaptoethanol, and lyophilized.
|Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF.
|12.5% SDS-PAGE Stained with Coomassie Blue after protein purification.
|Samples are stable for up to twelve months from date of receipt.
|1. Centrifuge the tube for a few seconds and ensure the pellet at the bottom of the tube. 2. Re-dissolve the pellet using 200μL pure water and boil for 2-5 min. 3. Store the lyophilized cell lysate at 4℃. After re-dissolution, recommend to aliquot it into smaller quantities and store at -80℃.
|1 X Sample Buffer (1 X modified RIPA buffer+1 X SDS loading buffer).
|Store at 4℃. After re-dissolution, aliquot and store at -80℃.
|Western blot (WB): Use at an assay dependent dilution.
Other Applications: Not tested.
Optimal dilutions/concentrations should be determined by the end user.
CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.


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Checking in with the herd
The 2014 State of the Herd Report is out, and this year's pony fans are marginally more female, a teensy bit more married (though 4.7 percent won't overwhelm the Los Pegasus wedding chapels), and just about as likely to pester friends and neighbors to watch the darn show already.
A few not-entirely-random quotes from the report:
Utah has the most Bronies per 100,000 … followed closely by Alaska. Mississippi, once again, is dead last in per capita Bronyism.
Utah checks in with 9.03 per 100k; Mississippi, 1.87. (Oklahoma, should you be curious, is mid-pack at 4.47.)
There's a very distinct gender break on the Pegasister question. While 60% of males basically "meh" at the question ["Women should be pegasisters," as distinguished from bronies], 47% of females either disagree or strongly disagree, with only 14% agreeing or strongly agreeing.
A desire not to be segregated? Fancy that.
On the question of Favorite Character, it takes seven slots to include the Mane Six, since Princess Luna has vaulted all the way to third. (Derpy is eighth.) And this is a trifle alarming:
As you look through the list, stop to consider that Tom, a piece of rock, drew more votes than Flim, Flam, and either Mr. or Mrs. Cake.
And the data-collection period ended long before we met Pinkie Pie's sister Maud, so I see Tom, if only as a possible ship for Maud, gaining popularity in the near future. Also, Flam outdrew Flim, which makes me wonder if people can really tell them apart.


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Remote TV Controller for Samsung Smart TV & Watch
13 декември 2015, 19:51
About Remote TV Controller for Samsung Smart TV & Watch
Getting lazy looking for the remote control hiding somewhere in the house. We have the solution Remote TV Controller allows you to remotely controll your Samsung TV set using your iPhone/iPad or simply using your brand new Apple Watch.
The app has been crafted and designed with most ergonomic elements and is the first app that help you controlling your TV simply using your Apple Watch
We have integrated the most useful command that we usually use in everyday life.
More command will be added in future releases.
Please leave us a review if you like the app and your feedbacks are welcome.
Simmilar Apps
16.12 10:49
01.12 19:52


text:
Institutional organisation, Aviva Investors Australia, has been building its stake in consulting and IT services provider
Aviva announced after the market closed on Monday that it was a substantial holder with a stake of more than 5 per cent in the company.
In the last three months, Oakton's share price has been fairly volatile, probably as a result of broader market conditions and profit-taking.
Since March, Oakton's share price has bounced back from an all-time low of 52¢ to a high of $4.30.
Aviva's largest and most recent addition to its holding occurred last week when it purchased approximately 450,000 shares for more than $1.6 million at an average price of $3.61.
Based on consensus forecast for 2009-10, Oakton's price-earnings ratio is approximately 16, slightly higher than one of its closest peers,
However, analysts expect Oakton to deliver stronger growth than SMS over the next two years.
The Australian Financial Review


text:
San Diego, CA (PRWEB) September 05, 2012
Tobias Nergarden issued some observations about the shift in tactics being reported among real estate investors today, and his opinion is that this may help home sellers or an online estate agency because the fact that investors are changing tactics is due to rising home sales, and is another sign of housing recovery.
U.S. News and World Report reports that real estate investors, who have been investing in real estate investment trusts (REIT) since the collapse of the housing market, are now investing in homebuilding companies. This is considered significant because REITs have been taking advantage of there being fewer home buyers after the crisis by investing in apartment complexes or other rentals like beachfront home rentals. Now, however, with a recovering housing market and lower prices, purchasing a home is in some cases less expensive than an apartment. A Goldman Sachs report also indicates that while members of the Millennial Generation are generally buying homes now, that this may change within the next five years as they save money and find more stable employment. With more demand for housing, REITs are looking less attractive for investors. Homebuilding companies like Toll Brothers, on the other hand, are. The reason for this is that Homebuilding companies have spent the last few years regrouping and are now exploring the fastest growing real estate markets, which means that a return on a stock investment is looking more lucrative.
A Real Estate Investment Trust, or REIT is an investment group designed to avoid corporate taxes. They do this by distributing 90 percent of their profits to investors. These groups can either be public or private, and in the United States, can operate, as well as own investment properties. These properties are therefore usually apartments or homes that are rented, the rental income being divided among the investors. Since the 2008 economic crisis, REITs have been performing well above average in terms of return on investment because they can adjust rents to cover costs and are considered flexible.
Toll Brothers is one of the largest homebuilding companies in the United States. Their business practices are not just limited to construction, however, as they are involved in land purchasing, architecture, and all other aspects of home development. They target markets that are seeing a rise in home sales and have a large amount of cash on hand in order to create developments quickly.
Goldman Sachs is a global financial firm headquartered in New York City. Although Goldman Sachs has been around since 1869, they have been under fire recently for alleged improper practices, mostly to do with their profiting during the current financial crisis. Many former government officials such as former Treasury Secretary Rick Rubin, worked for Goldman Sachs before their government positions.
The Millennial Generation is known for being tech-savvy and for enjoying social networking. They are also more likely to want to live with a more connected lifestyle, in closer physical proximity to other people and are less concerned with privacy. This generation is more loosely defined than other generations, but currently, experts are considering anyone born between the late 1970's and the late 1990's to be part of this generation.
Real Estate Marketing Insider today commented on departure of real estate investors from REITs to homebuilding firms.
About Real Estate Marketing Insider:
Real Estate Marketing Insider provides online tips to real estate professionals regarding hot news, trend analysis, and marketing strategies. This publication is based out of La Jolla, CA.


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By Kozo Mizoguchi, Associated Press
TOKYO Archaeologists digging in western Japan have excavated what they believe to be the oldest remains of a melon ever found, an official said Friday.
Based on a radiocarbon analysis, researchers estimate the half-rounded piece of fruit to be about 2,100 years old, said Shuji Yamazaki, a local official in the city of Moriyama.
The remains are believed to be the oldest of a melon that still has flesh on the rind, Yamazaki said. Previously, the oldest such find was believed to be remains found in China that date back to the fourth century A.D., according to local media reports.
The melon might have been so well-preserved because it was in a vacuum-packed state in a wet layer below the ground, an environment hostile to microorganisms that might otherwise have broken down the remains, Yamazaki said.
Melon seeds have been often found in archaeological digs around the country, but researchers rarely find the remains of melon flesh, Yamazaki said.
Moriyama is about 330 kilometers (205 miles) southwest of Tokyo.
Copyright 2007 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Conversation guidelines: USA TODAY welcomes your thoughts, stories and information related to this article. Please stay on topic and be respectful of others. Keep the conversation appropriate for interested readers across the map.


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- 4 total posts
- 3 comments
- 1 question
Questions from HeatherH
Leaking fluids from incision line 8 weeks post op. Had infection wound stitched up, 5 days later started leaking.Is this normal?
Late April I had TT with Lipo of flanks and back. 9 days pst-opt drain bag was removed. 1 week after bag remove incision line opened to release fluid. 5 weeks ps-opt massive... READ MORE
Recent comments from HeatherH
After speaking more in-depth with my doctor (board certified demonologist/plastic surgeon) she said that this procedure is better on upper arms and on the back. She says she has not seen the results she likes on the abdominal region and... READ COMMENT
Wow!! THank you for all the input. I really appreciate it!! So I do Work out 4 days a week and watch what I eat it seems that I lose weight everywhere else but my tummy. I never had this problem before. The only thing I can think of is... READ COMMENT
OK After having my second child in my late 30's it has been so hard to lose my belly.I work out about 4 times a week and try to watch what I eat but it just does not want to leave. I was looking into this instead of lipo but was not... READ COMMENT


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- InStyle was honored on Advertising Age's A-List as one of the top five magazines of the year in both 2012 and 2013.
- InStyle is the best-selling core fashion media brand on the newsstand, and the only one to be ranked among the top 10 best-selling weeklies and monthlies combined.
- InStyle has led the entire fashion and beauty category with the most ad pages for five consecutive years (2009-2013) and maintains the largest female audience in the fashion and beauty category with a household income above $150,000.
- InStyle has 17 editions outside of the United States: Australia, Brazil, Czech Republic, Germany, Greece, Hungary, Indonesia, Korea (two editions), Mexico, Poland, Russia, Spain, Thailand, Turkey (two editions), and UK.
Laura Brown


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You found probably the funniest site of the internet! Share and discover hilarious, crazy and weird videos, images or what ever you want and find people who share your sense of humour.
We suggest English as your preferred language. You can change the language next to the bendecho logo.Let it rock! ;-)
Dust in the Wind
dont-panic.co.uk - All we are is dust in the wind. Everyone's die some day. Take a look these explicit photos of morgue.
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Seventh Framework Programme (FP7)
The complete name of FP7 is 7th Framework Programme for Research and Technological Development. It will last for seven years from 2007 until 2013. The programme has a total budget of over €50 billion. FP7 is a key tool to respond to Europe's needs in terms of jobs and competitiveness, and to maintain leadership in the global knowledge economy.
FP7 bundles all research-related EU initiatives together under a common roof playing a crucial role in reaching the goals of growth, competitiveness and employment; along with a new Competitiveness and Innovation Framework Programme (CIP) , Education and Training programmes, and Structural and Cohesion Funds for regional convergence and competitiveness. It is also a key pillar for the European Research Area (ERA) .
The broad objectives of FP7 have been grouped into four categories: Cooperation, Ideas, People and Capacities . For each type of objective, there is a specific programme corresponding to the main areas of EU research policy. All specific programmes work together to promote and encourage the creation of European poles of (scientific) excellence.
The specific programme on Cooperation supports all types of research activities carried out by different research bodies in trans-national cooperation and aims to gain or consolidate leadership in key scientific and technology areas, with the allocated budget of €32,413 billion. The Cooperation programme is sub-divided into ten distinct themes.
Information & communication technologies (ICT)
is one of the themes. The objective of ICT research under the FP7 is to improve the competitiveness of European industry – as well as to enable Europe to master and shape the future developments of these technologies so that the demands of its society and economy are met. The EU Member States have earmarked a total of € 9.1 billion for funding ICT over the duration of FP7; making it the largest research theme in the Cooperation programme, which is itself the largest specific programme of FP7 (with 64% of the total budget).
FP7 research activities will strengthen Europe's scientific and technology base and ensure its global leadership in ICT, help drive and stimulate product, service and process innovation and creativity through ICT use and ensure that ICT progress is rapidly transformed into benefits for Europe's citizens, businesses, industry and governments.
For more information about FP7 see FP7 Homepage and FP7 in brief ( brochure )
If you want to participate check, FP7 Participation , Participating in European ICT research
Our FP7 projects : link
Open Calls
Coordinated EU-Japan call
Call 10 under Workprogramme 2013
Objective 1.5: Trustworthy ICT
This objective addresses cyber security and privacy in three major technological areas: cloud computing, mobile services and the management of cyber incidents. Activities will cover R&D and innovation activities, including the adaptation and integration of technology and demonstration in real life environments, from the design to the implementation stage. This objective also aims at supporting trust and security policies.
Main target outcomes are:
- Security and privacy in cloud computing
- Security and privacy in mobile services
- Development, demonstration and innovation in cyber security
- Technologies and methodologies to support European trust and security policies
- EU-Australia cooperation on building user trust in broadband delivered services
Closed Calls
Call 8 under Workprogramme 2011-2012
Objective 1.4: Trustworthy ICT
The objective is a trustworthy Information Society based on an ecosystem of digital communication, data processing and service provisioning infrastructures, with trustworthiness in its design, as well as respect for human and societal values and cultures. Projects must ensure strong interplay with legal, social and economic research in view of development of a techno-legal system that is usable, socially accepted and economically viable.
There are four main target outcomes:
- Heterogenous networked, service and computing environments
- Trust, eIdentity and Privacy management infrastructures
- Data policy, governance and socio-economic systems
- Networking and coordination activities
Joint call between ICT and Security Themes on Critical Infrastructure Protection
Call 5 under Workprogramme 2009-2010
Objective 1.4: Trustworthy ICT
Target outcomes:
- Trustworthy Network Infrastructures
- Trustworthy Service Infrastructures
- Technology and Tools for Trustworthy ICT
- Networking, Coordination and Support
Call 1 under Workprogramme 2007-2008
Objective 1.4: Secure, dependable and trusted Infrastructures
Target outcomes:
- Security and resilience in network infrastructures
- Security and trust in dynamic and reconfigurable service architectures
- Trusted computing infrastructures
- Identity management and privacy enhancing tools
- Longer term visions and research roadmaps


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A statement from MPD regarding the atttack reads, "We are investigating an Aggravated Assault that may have been motivated by hate bias. The GLLU was notified. Sunday, July 22, 2012, at approximately midnight, two complainants were in the 1900 block of 3rd Street NE when three suspects appeared from an unknown direction and began to yell homophobic slurs at them. The three suspects then approached the complainants and assaulted them. Suspects fled in an unknown direction, one complainant was taken to a local hospital for treatment for his injuries. Lookout is for three black males wearing dark clothing."
Gay Couple Attacked in Eckington: Hate crime investigation underway.
Current Status: Published (4)
Seeded on Tue Jul 24, 2012 6:47 AM
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The corporate regulator has suspended the financial services licence of LM Investment Management for two years.
The funds management empire, worth $740 million, belongs to embattled Gold Coast businessman Peter Drake.
The decision by the Australian Securities and Investment Commission to suspend LM's licence makes it impossible for administrators to hand the business back to the company's directors, as had earlier been suggested by the administrators.
The administrators - John Park and Ginette Muller of FTI Consulting – will this Friday apply to the Queensland Supreme Court to take control of the fund as its receivers.
Last week the administrators revealed the failed funds management empire lent $301 million to Mr Drake and his companies.
The loans were made from the LM Managed Performance Fund, one of the empire's many funds, which operated outside Australian company law.
The related-party loans included $17 million lent directly to Mr Drake, the administrators said.
The suspension allows administrators to transfer to a new responsible entity, investigate or preserve the company's assets or wind up the registered managed investment schemes operated by LM.


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Daily Devotionals Subscribe by EMAILPrayer RequestsJoin Prayer TeamGod's PlanAbout Us
Home :: Bible Studies :: Filled with the Holy Spirit
How to be Filled with the Holy Spirit - Part 3
by Dr. Bill Brightpg 1, pg 2, pg 3 Share page
How to Know
Did you ask God to fill you with the Holy Spirit? Do you know that you are now filled with the Holy Spirit? On what authority? (On the trustworthiness of God Himself and His Word: Hebrews 11:6; Romans 14:22, 23.)
Do not depend upon feelings. The promise of God's Word, not our feelings, is our authority. The Christian lives by faith (trust) in the trustworthiness of God Himself and His Word.
This train diagram illustrates the relationship between fact (God and His Word), faith (our trust in God and His Word), and feeling (the result of our faith and obedience) (John 14:21).
The train will run with or without the caboose. However, it would be futile to attempt to pull the train by the caboose. In the same way, we, as Christians, do not depend upon feelings or emotions, but we place our faith (trust) in the trustworthiness of God and the promises of His Word.
How to Walk in the Spirit
Faith (trust in God and in His promises) is the only means by which a Christian can live the Spirit-directed life. As you continue to trust Christ moment by moment:
Spiritual Breathing
By faith you can continue to experience God's love and forgiveness.If you become aware of an area of your life (an attitude or an action) that is displeasing to the Lord, even though you are walking with Him and sincerely desiring to serve Him, simply thank God that He has forgiven your sins - past, present and future - on the basis of Christ's death on the cross. Claim His love and forgiveness by faith and continue to have fellowship with Him.If you retake the throne of your life through sin - a definite act of disobedience - breathe spiritually.
Spiritual breathing (exhaling the impure and inhaling the pure) is an exercise in faith that enables you to continue to experience God's love and forgiveness.
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Thad Jones, Clark Terry, and James Williams:
The Living Jazz Archives in Word,
Performance, and Photographs
The Living Jazz Archives at William Paterson University houses the collections of three of the jazz world's iconic peformers: Thad Jones, founding director of the University's Jazz Studies Program; Clark Terry, legendary trumpeter and long-standing jazz faculty member; and James Williams, the late pianist, music educator, and director of the University's Jazz Studies Program from 1999 until his untimely death in 2004. The collection features annotated scores of these and other composer-performers as well as recordings and a copious visual archive of photographs and posters.
Please plan to join us for this exploration of jazz history in word, performance, and photographs made available through the Living Jazz Archives.
Date: Sunday, December 2, 2012
Time: 2:00 p.m.
Location: Cheng Library Auditorium
Admission is free
Light Refreshments to follow.
Sponsored by Friends of the Cheng Library of William Paterson University
For additional information about this event, please call the Cheng Library at 973.720.2113.
Directions can be found at www.wpunj.edu/directories/directions-and-map.dot


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|Home > National News > Article
He said he had discussed the leadership with Mr Costello in February, but sources said he indicated he had not made a decision. He also denied there was any succession deal, and said his decision to stay on was not made to humiliate or "inflict any kind of pain" on his deputy.
"I have no doubt that the next leader of the Liberal Party will be Peter Costello - I'm sure of that," he said.
Mr Howard said Mr Costello had "a perfect right to have ambition", and endorsed Mr Costello's announcement that he would speak out on more issues.
Mr Costello, who disagreed with Mr Howard's handling of reconciliation issues (shown by taking part in a Melbourne walk) and the response to Pauline Hanson's One Nation party, said he wanted a more tolerant society.
"One of the values that I think is very important to Australia is that we be a tolerant society, and that that is reflected in all of our dealings in our communities, in our neighbourhoods," he said.
Mr Howard said he discussed his future with his wife, Janette, and three children and they unanimously agreed with his decision to stay.
"I listened to quite a number of people. I came to the view that there seemed to be a sentiment in the parliamentary party and the party organisation and in the broader community that I should continue," he said.
He said he expected to continue to have a close working relationship with Mr Costello. "He is too dedicated and too committed a person to public service to do otherwise."
Mr Howard said he had no plans for a "major reshuffle", but would not rule out "changes at the margin".
He said he expected to lead the Liberals to the next election, due by April 2005, but did not take victory for granted.
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|Beazley plots bid for top job
|Beazley and his roosters drink to the revolution
|PM upholds Costello as successor
|Patterson defends record
|Shaun Carney: Where to now for Costello?
|Kenneth Davidson: Forget the top job, Peter - you're no good as Treasurer
|Feedback: Letters 05/06/03
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Pretending to be my best friend he sought the occasion of a heart-to-heart with me.
Do get him here, Mabel, and have a heart-to-heart talk, all three of you!
That afternoon, after Peter had cooked a wonderfully good luncheon, I had a heart-to-heart talk with Blenkiron.
He had come to have a heart-to-heart talk with me, I learned, and I was soon on the defensive.
The day after the meeting is the time for personal work, for hand-picked fruit, for heart-to-heart conversations.
After she had gone Mrs. Allan and I had a heart-to-heart talk.
I've realised it since a heart-to-heart talk old Con forced me to have with him a fortnight before we sailed.
He was friendly enough, but showed no inclination for heart-to-heart confidences.
When this is not done, I have them meet me in the chapel for a heart-to-heart talk about the conduct of the school.
"I want to have a heart-to-heart talk with you, mother," said Grace, hesitatingly.


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Ask an Eye Doctor and Get an Answer ASAP
My name isXXXXX and I will be assisting you with your question.
I have few questions for you so that I can give you good information to assist you decisions.
What type of prescription drops are you using? How about other medications you are currently taking? If they are many - tell me what your are using them for?
Are you diabetic or Hypertension?, and have you had any laser treatment in your eye(s)?
Which eye is the epiretinal membrane?
What other eye problems do you have? Glaucoma?
Thank you.
On July 20th, I had cataract surgery on my right eye. For the first couple of days, my vision was very clear but became somwhat cloudy as time went on. I was prescribed Pred Forte and Nevanac. After 6 to 8 weeks there was not much improvement. After the first digitial photo, I was told it was some swelling. After about 6 weeks and a second photo I was told the swelling was reduced. However, my vision was not much improved. After the third photo, I was told it was epie retinal membrane. I was also told to arrange to be fitted for corrective lenses.
About 4 years ago I had Lasik surgery on both eyes. I use monovision even today with my right eye seeing distance. Before Lasik my right eye was about 20/700 and my left about 20/600.
Thank you for your reply.
It's likely that after your cataract surgery you developed cystoid macular edema (i.e. swelling in the macular area of the retina - CME). This is a common complication after intraocular surgery, commonly cataract. Most of the time, aggressive treatment with steroid drops like pred forte, nevanac or acular and/or sub tenons injection of Kenalog to effective quiet down the inciting inflammation will resolve it.
From the description of your vision prior to LASIK it appears the you were high myope with thin/stretched retina to begin with, and so at higher risk for macular swelling with intraocular surgery. The epi-retinal membrane - ERM (thin fibrous film) likely developed as a result of inadequately controlled inflammation and/or complication of the CME. At this time, the best option for removing the ERM and improve your vision may be a retinal procedure by a retinal surgeon to gently peel off the film from the surface of the macular.
The time of such ERM peel is best determined by the retinal eye surgeon after evaluation. So, a referral to a retinal surgeon may be in order at this time. On the other hand, if the vision is not severely affected, continuing to use pred forte and nevanc and/or adding kenalog injection could enhance the recovery.
I trust that you will do well. Continue to ask question - and persist, and you will be alright. Thank you so much. I hope I could be of assistance in the future. May God bless.
I hope the above information is helpful. If you agree, please click the ACCEPT button.
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Madden NFL 15 on Playstation 4 (PS4)
Cheat codes, unlockables, hints, easter eggs, glitches, guides, walkthroughs, videos and more for the Playstation 4. Cheats.co has everything you need to dominate in-game!
Navigate using the links above or browse the Playstation 4 cheats we have available for Madden NFL 15 below. The most liked items overall will appear first in their respective section.
Submit Some Content! Leave a comment!
- Genre: Sports,Football
- Platforms: Xbox 360,PlayStation 3,PlayStation Network (PS3),Xbox One,PlayStation 4
- Developer: EA Tiburon
- Publisher: EA Sports
- Ratings: ESRB: E,OFLC: G
- Release Date (original): 2014-08-26 00:00:00


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Copper and gold developer
Fresh from winning the Mining 2010 explorer of the year award at the Mining 2010 Resources Convention in Brisbane, Exco Resources managing director
Mr Anderson admits the copper project has had a "relatively slow gestation", having been with the company for more than 10 years.
But he said the company is well placed to take advantage of strong gold prices as it prepares feasibility studies for the Cloncurry Copper Project.
"Our job now is to extend that mine life as best we can and make the most of the opportunities that we've created," he said.
The Cloncurry project features a resource base of more than half a million tonnes of copper and half a million ounces of gold, with further resource upgrades expected by the end of the year.
The company made the transition from explorer to producer earlier this year, bringing on production at the White Dam gold project at an annualisec rate of around 65,000 ounces a year.
Cash sales from the project will be used to fund the development of the Cloncurry project following the completion of feasibility studies.
Exco is considering the cost required to build its own processing facilities at the site, which would be needed if the company was unable to secure processing supply at the Xstrata project some 8 kilometres away.
The potential to use the processing facilities came about when Xstrata said the Ernest Henry project would run at reduced capacity after the miner scaled back proposed production from underground operations.
Successfully securing a supply agreement with Xstrata would allow the company to avoid around $200 million worth of capital expanditure required to build its own processing facilities as the Cloncurry project.
Further exploration north of the Cloncurry deposit at Hazel Creek tenements are planned for 2011.
The Australian Financial Review


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FROM THE PUBLISHER >> Every death is like a loss in the family
Leader publisher
Several of our friends passed away last week. Two died on the same day, and another at weeks end.
Then came word Tuesday morning that U.S. forces recovered the remains of two American soldiers whod been kidnapped in Iraq, their bodies booby-trapped and mutilated, their features destroyed beyond recognition after hours of unimaginable torture.
Pfc. Kristian Menchaca and Pfc. Thomas L. Tucker, who have been identified through DNA testing, were abducted Friday from a traffic-control checkpoint in Yusufiya, south of Baghdad. A U.S. soldier was killed at the scene.
When we hear about the death of an American in Iraq, its as if we know them and theyre members of our family. When we went to the funeral of Specialist Bobby West in Beebe a couple of weeks ago, along with hundreds of Patriot Guard Riders, we felt as if we were part of the West family as they mourned the passing of a wonderful young man at the age of 23.
Others whose obituaries we ran last week lived much longer, and yet they, too, left us too soon.
Dr. Donnie Griggs, the Jack-sonville dentist who touched the lives of hundreds of patients and children whose teams he coached, died suddenly Sunday before last.
His funeral last Wednesday at First Methodist Church in Jack-sonville was one of the biggest weve seen here: Mourners packed the sanctuary and the halls outside, where lines reached almost to the parking lot.
As one speaker said, Dr. Griggs was like a second father to the children he coached. Many of those children, along with their parents, were at the funeral service. It seems as if almost every summer when our kids came home from college, they went straight to Dr. Griggs office for dental work.
He always smiled and made them feel comfortable. Thats how Dr. Griggs was: Unassuming and always there to help.
Its hard to believe that hes gone at the age of 51 much too soon.
The same day that he passed away, retired Lieut. Col. Harold A. Kohnert died at the age of 86 in Las Vegas. A veteran of the Second World War, he was a pilot and squadron commander who had a second career in Jacksonville after he left the Air Force.
Kohnert started investing in real estate more than 30 years ago with his partner William Marr, another Air Force colonel.
They worked quietly on their investments, but they were so down-to-earth that youd never guess they were wealthy by the time they retired.
Lloyd Friedman calls Kohnert a visionary. He and Marr bought land along Hwy. 67/167, a corridor that includes the Wal-Mart Super-center, Chilis, Waffle House and much more. They rented us a small space on John Harden Drive, where The Leader got its start.
Word of the death of Jackson-ville Alderman Robert Lewis reached us on Thursday. He, too, was a quiet, unassuming man. He knew all about loss and pain and suffering. He died after a long illness, but even before he became ill, tragedy struck the Lewis family when their daughter was senselessly murdered in the Sunnyside Addition.
We will miss these fine Americans who lived their lives in dignity, who inspired us to emulate their courage and devotion to their families, their communities and their country. May they rest in peace.


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Get an overview of this hotelSuburban bed & breakfast in Kingston with free breakfast
Popular property highlights
With a stay at Neita's Nest - Jamaican Bed & Breakfast in Kingston, you'll be in the historical district and close to Manor Park Plaza and Kings House.
This bed & breakfast is within the vicinity of Bob Marley Museum and Devon House.
Make yourself at home in one of the 3 individually decorated guestrooms. Complimentary wireless Internet access is available to keep you connected. Detached private bathrooms with shower/tub combinations feature complimentary toiletries and bathrobes. Conveniences include desks and complimentary bottled water, and housekeeping is provided daily.
Treat yourself with massages and facials. Additional features at this bed & breakfast include complimentary wireless Internet access and tour/ticket assistance.
A complimentary full breakfast is served daily.
Featured amenities include express check-in, dry cleaning/laundry services, and luggage storage. A roundtrip airport shuttle is provided for a surcharge (available 24 hours), and free self parking is available onsite.Information missing or incorrect? Tell us!Opens in a new window
Neita's Nest - Jamaican Bed & Breakfast
Bed & Breakfast Amenities
Bed & Breakfast Amenities
Guests can enjoy a complimentary breakfast each morning. Wireless Internet access is complimentary. For a surcharge, a roundtrip airport shuttle (available 24 hours) is offered to guests. This Kingston bed & breakfast also offers a library, a terrace, and tour/ticket assistance. Complimentary self parking is available on site.
- Airport transportation (surcharge)
- Total number of rooms - 3
- Number of floors - 2
- Coffee/tea in common areas
- Free breakfast
- Dry cleaning/laundry service
- Express check-in
- Front desk (limited hours)
- Tours/ticket assistance
- Free WiFi
- Library
- Garden
- Terrace
- Luggage storage
- Free self parking
- Year Built 1968
- Number of buildings/towers - 1
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Ceiling fan
- Free bottled water
- Daily housekeeping
- Bathrobes
- Free toiletries
- Hair dryer (on request)
- Shower/tub combination
- Desk
- Iron/ironing board (on request)
- Portable fan
- Private bathroom (not in room)
- Free WiFi
- Individually decorated
Where to Eat
A complimentary full breakfast is served each morning between 7 AM and 10 AM.
Start your day with a free full breakfast, available daily from 7 AM to 10 AM.
Spa Services
- Deep tissue massage
- Swedish massage
- Manicures and pedicures
- Aromatherapy treatments
- Massages
- Facial treatments
Bed & Breakfast Policies
Check-in time starts at 3 PM
Check-in time ends at 11 PM
Minimum check-in age is 18
Special check-in instructions:
Check-out time is 11 AM
Children and extra beds
- Children are welcome.
- Rollaway/extra beds are not available.
- Cribs (infant beds) are not available.
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Cash Deposit Required
No rollaway/extra beds available
No cribs (infant beds) available
This property accepts cash only for housekeeping fees and the city tax. For more details, please contact the office using the information on the reservation confirmation received after booking.
- A tax is imposed by the city: USD 1.00 per accommodation, per night
- Resort fee: USD 25.00 per accommodation, per night
- Housekeeping
Optional extras
- Airport shuttle fee: USD 63.00 per vehicle (one way)
- Early check-in fee: USD 30.00
- Late check-in fee: USD 30.00 for check-in after 10 PM
- Late check-out fee: USD 30.00
Bed & Breakfast Name
- Neita's Nest
- Neita's Nest Bed & Breakfast
- Neita's Nest Jamaican
- Neita's Nest Jamaican Bed & Breakfast
- Neita's Nest Jamaican Bed & Breakfast Kingston
- Neita's Nest Jamaican Kingston
- Neita's Nest Jamaica/Kingston
- Neita's Nest Jamaican Bed Breakfast
We should mention
This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details 24 hours prior to arrival, using the contact information on the booking confirmation. Reservations are required for massage services and spa treatments. Reservations can be made by contacting the bed & breakfast prior to arrival, using the contact information on the booking confirmation.


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Marston Sleigh Bed Without Footboard Dark Cherry
- No Longer Available -
Built of American dark cherry, Marston has clean lines and classic good looks.
Show Details +
- Queen Bed: 65"W x 95"L x 51"H
- King Bed: 81"W x 95"L x 51"H
- Cal King Bed: 77"W x 99"L x 51"H
Shown in dark cherry.
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Cyprus covers a total area of 9251 sq.km. and the estimated population is 750.000 of which 80 per cent are of Greek origin. The island's time zone is 7 hours ahead of New York and 7 hours behind Tokyo and therefore enables transactions to be carried out with any part of the world the same day.
Cyprus has an open economy based on a free enterprise system and has enjoyed consistent economic growth during the last decades. It is a member of the United Nations, the Commonwealth, the European Union and the council of Europe.
As measured by relevant socio-economic indicators the standard of living in Cyprus is fairly high and is comparable to European levels. In addition Cyprus provided pleasant living conditions, at relatively low cost, a very low crime rate, pleasant climate and a clean and healthy environment.
Cyprus recognizes the importance of telecommunications and has invested heavily in on this sector. The island may claim to be among the most developed countries in the world. All modern telecommunication services are provided using state-of-the-art technology.
As a result of the high educational level of the population (95% literacy rate) and due to historic and economic links between Cyprus, Britain and other European countries, legal, accounting, management, computer and other services are of the highest standard. Nearly all international accounting firms are represented in Cyprus either through member firms or associated practices, a fact that ensures international standards in the quality of accounting and audit services.
The reputation Cyprus has as a major international business center is not only based on its strategic location.
The excellent infrastructure, the advantageous trust legislation, based on English Law offering asset protection and confidentiality, as well as low formation and operating costs, create and ideal environment for the international business industry.
It offers an excellent center for the establishment of corporate entities with advantages unparalleled in other jurisdictions.
Cyprus has concluded a large number of double tax treaties with 27 countries including Greece, Russia, United Kingdom and China which provide tools and opportunities for optimum tax planning.
Some major fiscal incentives are
The incorporation of International Business Companies in Cyprus is carried out by accounting and law firms. The following documents are acquired:
Ø Certificate of Registration
Ø Memorandum and Articles of Association
Ø Certificate of Directors and Secretary
Ø Certificate of Shareholders
Ø Certificate of the company's registered office
Documentation may differ depending on the jurisdiction of registration.
The National Bank of Greece (Cyprus) Ltd is a wholly owned subsidiary of the National Bank of Greece SA.
National Bank of Greece SA, established in 1841, the oldest and largest among Greek banks heads the strongest financial group in the country. It boasts a dynamic profile internationally, particularly in Southeastern Europe and Eastern Mediterranean. It ranks among the most robust financial services conglomerates of the world delivering its services through 1059 branches worldwide. Since October 1999, the Bank has been listed on the New York Stock Exchange.
On the international level the Bank aims to establish itself as one of the major European banks. The wide geographical spread of the international operations of the Group allows the Bank the exploit growth opportunities in countries where it enjoys competitive advantages and offer to International Investors, International Business Companies and other International Groups high level financial services such as Commercial Lending and Financing, Private and Retail Banking, Mortgage Lending, Investment Banking Services, Treasury Activities and Insurance.
The presence of National Bank of Greece in Cyprus since 1907 is identified with the evolution of the business world in Cyprus.
The modern and flexible operating system of National Bank of Greece (Cyprus) Ltd combined with the know-how, the experience the international connections and presence of its mother company, permits the Bank to offer all its customers direct and personalized service on a full range of financial products.
NBG - International Business Unit
We, at the International Business Unit, combining our knowledge and expertise in the international business field, offer personalized high standard and professional services assuring the provision of timely, accurate and reliable response to our international customer needs.
As part of National Bank of Greece SA with a presence in virtually all the major financial marketplaces of the globe, we are able to delivery more financial solutions in more places around the world than any other local financial institution.
Bank Accounts:
Bank Cards:
Trade Finance:
The fees of all services are negotiable depending on the value, volume and frequency of transactions of the business requested by the client.
Our young and enthusiastic multilingual staff bound to the oath of secrecy and confidentiality with an extensive experience in serving international clients needs are at our customers disposal.
Managing Director: Mr M. Kokkinos
General Manager: Mr Petros Fronistas
National Bank of Greece (Cyprus) Ltd
International Business Unit (549)
22 Arch. Makarios III Ave.
CY - 1687 Nicosia
Telephone : +357 22 425468 / 840051 / 840053
Fax : +357 22 424480
Swift code : ETHNCY2N
Email Address: email@example.com
Head of Unit: Ms Maria M. Kiteou


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Lack of interest in reading could be hindering pupils' attainment
Scottish children read fewer books for pleasure than their international rivals, but conversely spend more time surfing the net and social messaging.
If teachers can find a way to increase the amount of time pupils spend reading - particularly longer, continuous texts - their attainment will rise.
For Sue Ellis, literacy expert at Strathclyde University, Scotland's poor showing in the reading section of the Pisa survey is a particular worry.
"Reading for pleasure increases children's general knowledge of the world, which benefits them right across the curriculum," she said. "It increases verbal reasoning and vocabulary and that gives benefits right across the curriculum. That is why it is a worry that kids are not doing as much reading for pleasure."
The concept of reading for pleasure should go beyond teachers recommending books for children and include teachers fostering children's social interaction around books in the way they interact via computers, she said.
Some schools were encouraging social networking around books by encouraging parents to share with each other information about their children's favourite books.
But Ms Ellis added that teachers in primary and secondary also had to include longer, continuous text as part of their teaching rather than the current emphasis on "short bits".
According to Jim Conroy, former education dean at Glasgow University, one of the most significant findings of the Pisa survey is that young people who are taught to read for meaning do best.
"That shows that synthetic phonics is not the answer because that method teaches people words, not meaning," he said.
He echoed Ms Ellis's comments on the need to increase young people's engagement with reading for pleasure.
"When you read for pleasure, you read for meaning," he said.
But David Turner, a literacy expert at Glamorgan University, suggested that Wales may have performed poorly compared to its UK neighbours in the international survey because of its focus on particular literacy skills which may count against the Welsh focus on bilingualism.
"There is a very strong spoken tradition in both languages in Wales - the things we value in Wales about literacy are not caught in a simple reading and writing test," said Professor Turner.
Other commentators familiar with both Welsh and Scottish systems suggest that Wales may have been caught by its radical change in curricular policy in the past decade. It had moved away from the English system of Sats- testing, to teacher-moderated assessment similar to that being adopted in Scotland.
Some of the smaller Welsh local authorities may also lack the capacity to support and challenge schools, it is claimed.


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Caplin & Drysdale has provided comprehensive legal service since 1964. We have remained a boutique law firm that focuses in tax, political law, employee benefits, exempt organizations, complex litigation, tax controversies and white collar crime. Our style of practice is aimed at minimizing our clients' liabilities without compromising the ethical principles that are essential to the legal system.
Caplin & Drysdale has broad experience advising business entities and their principals in tax planning with respect to both their operations and their transactions. Clients include domestic and foreign manufacturing and service companies, fund managers, financial institutions and insurance companies. The firm regularly advises with respect to corporate tax, partnership tax, subchapter S, the taxation of executive compensation, the taxation of financial products, the taxation of regulated investment companies and real estate investment trusts, the taxation of insurance companies and products, the taxation of royalty streams, tax accounting and payroll and other withholding taxes.
Federal, state, and local laws that govern political activities are increasingly numerous and complex. Inappropriate or illegal political activity can hinder work on important policy issues, impact a corporation's bottom line, or undermine a promising candidacy. Caplin & Drysdale's bipartisan Political Law group provides businesses, trade associations, nonprofits, candidates, and activists with timely, concise counsel on the high-stakes legal issues that involve "pay-to-play" restrictions, lobbying regulations, campaign finance laws, and ethics rules.
Our private client group counsels individuals and families on domestic and cross-border tax and estate planning issues, including the use of trusts, partnerships, corporations, foundations and wills and the application of tax treaties. We also represent domestic and international clients in disputes with the IRS regarding their income, estate, gift and generation-skipping transfer tax liabilities. We help individuals with their tax compliance issues, including pre- and post-immigration issues for international clients. We are one of the few firms with a focus on expatriation. Our attorneys draw upon their vast experience both in private practice and in government service to bring a uniquely informed perspective to our representations.
An IRS examination or audit can disrupt your business operations and, if not handled properly and controlled, can materially affect your relationships with third parties and shareholders, and ultimately your bottom line and share price. A taxpayer involved in an international tax controversy can face special challenges and opportunities, such as issues relating to foreign-based documents, the IRS's international summons and collection authority, and invocation of the Competent Authority relief procedures. Clients call upon Caplin & Drysdale for our broad knowledge of the tax controversy process and our superior relationships with the IRS and foreign tax authorities.


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Would You Wear: Lion Paw Louboutins?
Christian Louboutin's got lions on the brain. And on his toes. These very literal kitten heels might make you the queen of the jungle, but they'll also garner you a slew of strange looks. Then again, maybe you'll discover your inner fierce spirit animal. [Full Frontal Fashion]


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Lady Molly of Scotland Yard
Best known as the creator of the daring Scarlet Pimpernel, The Baroness Orczy (1865 1947) ought also to be remembered for bringing to life a trailblazing pair of detectives. One was the cranky Old Man in the Corner, an early armchair sleuth. The other isn t at all sedentary (and is a lot more likable) Lady Molly of Scotland Yard. Feisty, brilliant, and beautiful; precursor of the lay sleuth who relies on brains rather than brawn, Lady Molly, and her faithful sidekick and admiring chronicler Mary, began appearing in Orczy s entertaining stories years before the rst Englishwoman did in fact become an of cer of the law. These twelve clever, agreeably unportentous adventures of my lady were unknown to us before acclaimed novelist Alice Thomas Ellis brought them to our attention, and we re most delighted she did.
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Reviews & Stories
Radiesse, Not for Everyone, Turned my Skin Red Where It Was Injected - Arlington Heights, IL
I had radiesse done under my tear troughs. It filled nicely and I went back a couple weeks later to have a small touch up. Unfortunately where it was injected turned red and didn't go away for 2 months! I could cover it up with makeup and then my eyes looked nice because they were filled but when I took my makeup off at night that red skin was always there. About 9 months later, I had... READ MORE
Botox Brow Lift - Madison, WI
I turned 50 this year and have felt like my brows have really fallen which has made my upper eye lids sit very low, right on my eye lashes. This is true especially of my right brow and eye lid and I would draw the brow higher with pencil to make it look like it was at the same level as my left. I have thought about having an actual brow lift but I hate the thought of surgery so decided to try... READ MORE
Love Results, Wasn't Prepared for Initial After Effects - Elk Grove, IL
After some research I decided for the first time to have Juvederm injected into my upper lip to get rid of lip lines. I am 46 years old and had a couple deep ones but in general felt like my lip was slowly sinking in. THE PROCEDURE ON A FRIDAY AT NOON: All went well in the office, he used a dental block that totally numbed my lips so I had no discomfort, I left pretty puffy because of the... READ MORE
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I thought I replied to this already....but I must have submitted it wrong. I think they used 20 units. I can't tell you exactly the areas because they need to watch your muscles work before doing it. I can tell you it was 3 around... READ COMMENT
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Sure, I will let you know. I'm pretty sure the fillers are lasting longer now because I've had them done consistently every year. I read they leave a little structure and if you do it again before its totally gone you will get longer... READ COMMENT
Yes, we'll see though she said I should have it done again at 4 months and then after that will probably be able to go 6 months. I've had juvederm done in my lips for lip lines and a little more fullness once a year for about the... READ COMMENT


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No matter where the day takes you, stay covered up and cozy with this versatile hooded vest that warms your core but still fits under your jacket.
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Substance Priority List (SPL) Resource Page
This web page provides supporting information regarding the development of the Substance Priority List, as well as, expanded information on this list and past lists.
Support Document to the 2015 Priority List of Hazardous Substances - This Support Document describes the methodology used to generate the substance priority list.
Detailed Data Table for the 2015 Priority List of Hazardous Substances - This detailed data table provides a breakdown of the components that determine the total point scores used to rank candidate substances for the substance priority list.
Changes in prioritized substances relative to the last SPL – Substances new to the 2015 Substance Priority List, and substances that were on the previous SPL but are not on the 2015 List.
Full SPL Data - A spreadsheet with SPL detail in a filterable numeric format along with additional supporting information, such as the standard deviations for geometric means, number of data points in the means, and the number of sites from which concentration data was collected. The spreadsheet includes data from past SPLs and includes summary statistics for the dataset as a whole. Please refer to the cover sheet for more information on the data.
SPL Toxicity Values - A spreadsheet with a breakdown of the Toxicity/Environmental Scores (TESs) and a listing of Reportable Quantities used for the SPL.
Methodology for Toxicity/Environmental Scores - Describes the methodology used to determine the Toxicity/Environmental Scores (TESs) for the Substance Priority List.
SPL Federal Register Notices and Run Dates – A table of Federal Register Notices (FRNs) announcing the release of updates to ATSDR SPLs. It includes links to the FRNs themselves. The table also includes the date that the SPL was generated each year.
Previous Substance Priority Lists
(No List was published in 2009 while ATSDR transitioned to a new science database)
Contact Information
Further information can be obtained by contacting the ATSDR Information Center at:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO 888-232-6348 (TTY)
Email: Contact CDC-INFO
- Page last reviewed: May 7, 2014
- Page last updated: June 16, 2016
- Content source: