text:
Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Febuxostat Versus Allopurinol in the Treatment of Gout in Subjects 65 Years of Age: A Subgroup Analysis of the CONFIRMS Trial.
Krishnan1, Eswar, MacDonald2, Patricia A., Hunt2, Barbara, Jackson2, Robert
Stanford University, Stanford, CA
Takeda Global Research & Development Center, Inc., Lake Forest, IL
Efficacy and safety of urate-lowering therapy (ULT) in an older gout population has been infrequently reported. Febuxostat is a novel, non-purine, selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in patients with chronic gout. This is a subset analysis of 374 elderly subjects (>=65 years of age) from a total of 2269 subjects treated with febuxostat (FEB) or allopurinol (ALLO) for 6 months from the CONFIRMS study.1
Subjects with gout and serum urate levels (sUA) >=8.0 mg/dL were randomized to FEB 40 mg, FEB 80 mg, or ALLO (200/300 mg based on renal function) once daily. Gout flare prophylaxis (colchicine or naproxen) was provided for the entire study duration. The outcomes of interest were percent of elderly subjects with sUA <6.0 mg/dL by renal functional status and safety in this at-risk population.
The 374 subjects were predominately male (86%), Caucasian (85%), and obese (51% with body mass index [BMI]>=30 kg/m2), with a mean age of 71 years. Baseline characteristics and comorbidities were similar across groups; 82% had hypertension, 25% diabetes, 24% coronary artery disease, 21% cardiac arrhythmia, and 11% previous myocardial infarction. The three treatment groups were similar in age, gender, race, and duration of gout. Mean duration of gout was 15 years with a baseline sUA 9.4 mg/dL, with history of tophi (19%) and kidney stones (20%); 98% of subjects had some degree of renal impairment. Urate-lowering therapy use, at some time prior to study entry, was reported by 71% of subjects (ALLO 63% and 15% FEB). The proportions of subjects whose final sUA was <6.0 mg/dL were 62% (71/115), 82% (105/128), and 47% (62/131) in the FEB 40 mg, FEB 80 mg, and ALLO groups, respectively. Results by renal function status are presented in the table. The most frequently reported AEs irrespective of treatment were diarrhea (10%) and upper respiratory infection (8%). The majority were transient and resolved while on treatment. Serious AEs were reported by 8% in the FEB 40 mg, 6% in the FEB 80 mg, and 11% in the ALLO group. The most common serious AEs were cardiac disorders, 1%, 2%, and 3%, and lower respiratory tract infections, 1%, 0%, and 2%, in the FEB 40 mg, FEB 80 mg, and ALLO treatment groups, respectively. There were no hypersensitivity reactions. Overall response rates were similar to those seen in the combined CONFIRMS population.
Treatment with FEB reduced sUA to <6.0 mg/dL in this elderly population with significant cardiovascular comorbidities and was well tolerated. Response in the elderly moderately renally impaired population was statistically significantly better with either dose of FEB vs ALLO.
1.Becker, MA, et al. The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther 2010;12:R63.
To cite this abstract, please use the following information:
Krishnan, Eswar, MacDonald, Patricia A., Hunt, Barbara, Jackson, Robert; Febuxostat Versus Allopurinol in the Treatment of Gout in Subjects 65 Years of Age: A Subgroup Analysis of the CONFIRMS Trial. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :154
DOI: 10.1002/art.27923


text:
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|USS Alamance (AKA-75)
|USS Alamance (AKA-75) underway on the Cooper River off Charleston Navy Yard, S.C,, 15 January 1945.
US National Archives, RG-19-LCM, photo # 19-N-77195, a US Navy Bureau of Ships photo now in the collections of the US National Archives, courtesy Shipscrible.com.
|Robert Hurst
|Bow on view of USS Alamance (AKA-75) underway on the Cooper River off Charleston S.C, 15 January 1945.US Navy Yard Charleston, S.C. photo #159-45.
|Robert Hall
|USS Alamance (AKA-75) moored pierside, date and location unknown.
|Bob Denninger WT3/c USN, Alamance>i> January 1945 to May 1946
|USS Alamance (AKA-75) at anchor with boats alongside, date and location unknown.
|USS Alamance (AKA-75), at left, and USS Grafton (APA-109), at right, moored pierside at Sasebo, Japan, 1945
|Submitted by John Dupre' for his father-in-law Edmund H. Cokely EMC USN Asst Electrical Officer USS Grafton.
|Merchant Service
|Ex-USS Alamance (AKA-75) under way while in service as Prudential Line Shipping Co.'s SS Southstar, circa 1947-61.
|Hyperwar US Navy in World War II
|SS Southstar berthed at Bremen, Germany, early Fifties.
|Gerhard Mueller-Debus
|SS American Supplier leaving Bremen, Germany, March 1962.
|Photo by Gerhard Mueller-Debus
|SS Alcoa Voyager at Bremerhaven, Germany, April 1967.
|Photo by Gerhard Mueller-Debus
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|CDR. Stein, John Otto
|22 December 1944 - June 1945
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text:
LSU gets a new logo... but I haven't seen it talked about...
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text:
During the 2 weeks of the Olympics the Weymouth Bay Methodist Church are holding an exhibition (including sales) of local arts and crafts. All they ask for is 10% of any sale to be given to the Church. If anyone is interested in taking part just contact Pete at email@example.com or phone him on 01305 812637 .
Get the latest local news straight to your inbox every day


text:
Located on the first floor of the Sherrod Library, the Center for
Academic Achievement (CFAA) is the home of Learning Services (Tutoring), Testing Services, and the Office of Assessment. The mission of the CFAA is to present students with opportunities to learn and demonstrate their learning in a secure and supportive environment that encourages creative thinking, collaborative learning, and self-direction.
The CFAA is the place for students to go for help with:
Learning Services in the CFAA offers tutoring on a walk-in and appointment basis and is open evenings and Sundays. In addition to scheduling an appointment with a CFAA tutor, students can work on homework in the Center and attend Supplemental Instruction (SI) sessions for certain subjects.
The CFAA also supports faculty in classroom, curricular and programmatic evaluation and offers tools and assistance in improving classroom teaching and student learning.
In addition, CFAA Testing Services proctors online exams for ETSU courses and some national tests. Instructors can create their tests in D2L and then arrange with the Testing staff for their tests to be administered in the Center for students to take over the course of a day or days. The Senior Exit Exam (CCTST) and other assessments are also proctored in Testing Services.
CFAA staff members are happy to help students get answers to non-academic, college-related questions.
An Einstein's Bagels shop and a student lounge are located directly adjacent to the Center.


text:
Hi everyone,
I include Cufon fonts in my themes which are from fontsquirrel.com. I've included the licenses and everything, the problem is that those fonts are missing some special characters for other languages such as Hungarian.
I saw that cufonfonts.com have most of these fonts but are more complete in terms of special characters. I could not find any details in the site. Does anyone know if these are safe to be included in themes? or has anyone used fonts from that site?


text:
This Cruel War: Strategic Concepts in the Civil War
February 06, 2013 06:30 PM - February 06, 2013 08:00 PM
Location: Kapolei Public Library
Event Type: Lecture
Presented by— Justin W. Vance, HPU Assistant Professor of History
Battle in the American Civil War was heavily influenced by the legacy of Napoleonic warfare, yet the Civil War is often referred to as the first modern or total war. Through this lens of strategy and tactics, the technology, the great military leaders, and key campaigns and battles of the Civil War are analyzed.
This topic is part of The Gilder Lehrman Institute of American History Traveling Exhibition: Civil War 150 • January 28-February 9, 2013 • Kapolei Public Library
The Civil War is the most transformative period in US history. Drawing upon letters, personal accounts, and images, Civil War 150 invites Americans to understand how soldiers, presidents, freedmen, and families grappled with the end of slavery, the nature of democracy and citizenship, the human toll of civil war, and the role of a president in wartime.


text:
Four Year Roadmap
[For students qualified to enter first semester calculus (Math 30P), Phy 50, & Chem. 1A; other require pre-calculus math, summer school, and/or additional semester(s).]
Suggested Course Schedule (PDF Version)
Total Units for Major: 125
* Science 2 is recommended (not included in 125 unit degree requirement)
** Given in alternate years
Inquires should be directed to:
Eugene Cordero


text: The new Consumer Reports review of the 535 says the nav system "detects traffic snags but doesn't find you an alternative route." Does this mean there's no detour function on the nav system? Last week, my $120 Tomtom gave me a message saying "there's a 20 minute backup on your route. Would you like a faster route?" I punched yes and it routed me around the traffic jam I'm surprised that the costly system on the BMW doesn't do the same thing.


text:
A Short Update on the World of Adobe Acrobat
Wow, is it really the middle of May already? What happened to the time? I am sorry for not getting the opportunity to post anything over the last few weeks. What with spring vacations with the family, taking advantage of any nice day there is to get the garden in shape, the excitement over the new Star Trek movie, and lots of Acrobat-related projects that I have been working on, it has been hard to pay attention to you all. So please do accept my apologies.
While I was working on those other things, there have been some interesting developments in Acrobat-land:
- The Adobe Acrobat and Adobe Reader 9.1.1, 8.1.5 and 7.1.2 updates were released last week to address security vulnerabilities. If you have not done so already, it would be well worth subscribing to the Adobe Product Security Incident Response Team (PSIRT) and Adobe Secure Software Engineering Team (ASSET) blogs to stay up-to-date.
- Acrobat won a 2009 CODiE Award! The SIIA gave Acrobat 9 Pro Extended the award for Best Multi-Media Solution. What an honor! Our friends on the Acrobat.com, Creative Suite 4, LiveCycle and Captivate teams also won CODiE's. How cool is that?
- Amazon released the larger format Kindle DX. There is plenty of coverage of the eBook reading device already, and I do not have one (yet) to provide any comments, but the interesting news from Adobe's perspective is that Amazon (amongst others) is using the Adobe Reader Mobile SDK for built-in PDF viewing. Bill McCoy, who heads up Adobe's ePublishing Business wrote an article on this.
- Layers Magazine published their Fourth Annual Layers 100 Wicked Tips for all Adobe Creative Suite 4 applications. Lori DeFurio and I contributed 10 short tips on Acrobat 9 Pro for you to check out: they are about 1/3 of the way down (I wish the site authors had placed anchors, oh well). The other product tips are pretty good too.
- Speaking of Lori, her new show on Adobe TV called "Lori's Corner" was launched last week. Her first show has been posted, with her first very special guest: ME! Check it out, and let Lori (or me) know what you think. All I will say for now is, yes, we had considered wearing smoking jackets and holding brandy glasses, but Adobe legal would not allow it (just kidding). Enjoy!
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text: Hi, I tried to compile torque with the options --with-tcl and --enable-gui. The compilation and make finished successful but I can't find xpbsmon anywhere... I tried it too with option --with-tclx but that always gives me an error message? How do I get support for X? thanks, Robert -- Robert Tafner tafner at dpmi.tugraz.at, http://www.dpmi.tugraz.at Institute of Human Computer Interfaces University of Technology, Inffeldgasse 16a, 8010 Graz


text:
Ahwatukee resident Victor A. Cogco-Hernandez won a scholarship to the soccer camp of his choice this summer thanks to Scion, the Toyota car brand.
Throughout the month of May Scion set out to reward emerging young talent from diverse walks of life through its Scion Soccer Stars contest, in partnership with Arizona Youth Soccer Association (AYSA.)
Cogco-Hernandez, who will be a senior at Mountain Pointe this fall, is dedicated to helping his neighborhood as well as his friends and other students with their school loads while exemplifying a leader on the soccer field. Cogco-Hernandez is a goal keeper who is trying to be someone in life. His parents have a hard time as they solely Spanish-speaking, but he gives his all every single day, on and off the field. He has won many academic and soccer awards, and truly exemplified a what Scion stands for — showing a promising future as an entrepreneurial leader.
Send submissions to email@example.com


text:
Release Date: 12 March 2001 | Certificate: Suitable for 15 years and over
Featuring: Sean Connery, Christopher Lambert and Roxanne Hart
£4.49 includes FREE UK Postage (other delivery options available)
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Falkland Islands
Sorry, this product is currently unavailable.
The immortals are destined to live forever, but there can be only 'One...' From Sixteenth Century Scotland to present-day New York, the fate of mortal man hangs in the balance.
Trailer, Photo Poster Album, Filmographies, Chapter Search
Release Date: 12 March 2001
Certificate: 15 - Suitable for Persons Aged 15 or Over
Actors: Sean Connery, Christopher Lambert, Roxanne Hart, Clancy Brown, Patrick Stewart, Celia Imrie, Billy Hartman and Edward Wiley
Directed by: Russell Mulcahy
Region 2
Aspect Ratio: 1.85 Anamorphic Wide Screen
Sound: Dolby Digital 5.1\Dolby Digital 2.0
Running Time: 111 minutes
Production Year: 1985
Main Language: English
Subtitles: Dutch, French
Dubbed Languages: Italian, Spanish
For more information and our Delivery Policy see here.
For more information and our Returns Policy see here.
Customer Reviews
Exciting movie with lots of action
A novel way to show the pitfalls of immortality. A small group of men from different time frames deal with endless life, and death.
Catalogue No: D038352


text:
Sometime between this morning, when the NFL announced that the owners had voted unanimously to break off talks with the NFL Players Association and about 5:00 this evening, when the NFL announced that the free agency period would be delayed for three days in order for further talks with the NFLPA to take place, something happened.
Somebody blinked.
Earlier in the day, it appeared that virtually everyone involved was standing at the door of his own personal hell and was willing to walk through that door and into the teeth of whatever was awaiting them. For some, like the Redskins Dan Snyder, it was cap hell. For the players it was the certainty of a bloodbath of veterans getting cut and replaced by minimum-wage rookies and the uncertainty of a free agent market skewed by rules designed as poison pills to prevent things from ever getting to that point. For other owners, the so-called small-market teams, it was the prospect of a 2007 season without a salary cap, knowing that they wouldnt possibly be able to keep up with the teams with deeper pockets. For Paul Tagliabue, it was facing going into retirement in a few years with the legacy of leaving with scorched earth behind him. And Gene Upshaw, while hes managed labor peace well, is looking at again stepping into an arena where hes not been very successful. Hes 0-2 in games of brinksmanship with the NFL owners as his union was routed in both league players strikes in 1982 and 1987.
So, standing at the precipice, somebody got a bit wobbly. The brave talk, the unanimous votes, the well play it out and see what happens rhetoric of earlier in the day and the week suddenly rang hallow in someones mind. It was all false bravado. That somebody said, I cant possibly be this dumb, can I? I cant let this happen.
And he blinked.
Then he went to the phone and calls were made and all of a sudden things that appeared to be etched in stone in the morning suddenly transformed into mere lines in the sand. The start of free agency was delayed even though both sides were adamant that it would not be just a couple of days ago.
For both sides to have agreed to the delay, someone must have put a magic number out there, one that was, at the very least, good enough to the other side to jump start talks that were as dead as dead could be. That magic number must have represented enough movement for the other side to say, hey, I didnt really want to go through that door anyway. Couldnt hurt to sit down and talk a few more days, could it? Because Im not really sure what I was going to do tomorrow when all the stuff hit the fan, anyway.
So the millionaire players and the billionaire owners will take another three daysor maybe longer, who knows--to try to decide how to split up this huge pile of money.
And either somebody will blink one last time and a deal will be done or all of the parties involved will return to the gates of their personal versions of hell and pass through them.
Rich Tandler is a longtime writer for WarpathInsiders.com covering the Washington Redskins. You can read more of Rich's columns here: link


text:
Kevin Warsh, a governor at the Federal Reserve, has just delivered a very interesting speech in Atlanta.
His main point is that the Fed could start selling mortgage assets it bought to sustain the housing market during the crisis independently of its moves to raise interest rates, putting him squarely in the camp of inflation hawks on the Federal open market committee. Ben Bernanke, Fed chairman, has suggested that any asset sales should come only after monetary policy tightening underway, but Mr Warsh seems to disagree. "Any sale of assets need not signal that policy rates are soon moving higher. Our policy tools can indeed be used independently. I would note that the Fed successfully communicated and demonstrated its ability to exit from most of its extraordinary liquidity facilities over late 2009 and early 2010, even as it continued its policy of extraordinary accommodation," he said.
The Fed governor, a former Morgan Stanley investment banker and George W. Bush administration official, also attempted to quash the rising talk that the Fed might actually start buying assets again in response to continued weakness in the housing sector and the sluggish recovery, saying that such a move "should be subject to strict scrutiny". Read more


text:
Framed (ref: 1593)
Inscribed with title in pencil
Pen and ink, 3 1/2 x 3 3/8 in. (9 x 8.5 cm.)
Inscribed with title in pencil
Pen and ink, 3 1/2 x 3 3/8 in. (9 x 8.5 cm.)
During the Second World War Sheppard worked in the Royal Airforce photographic section.
Provenance: The Artist's Estate
Similar images were reproduced in Lilliput, (vol 41:4) to illustrate the wartime story Operation Jericho by Sandy Sanderson.
Lilliput was founded in 1937 by Stefan Lorant , (the photo journalist who later created Picture Post), with a subtitle of The Pocket Magazine for Everyone. Its original size was allegedly such that it could be slipped into a soldiers trenchcoat and was no doubt read in many an air-raid shelter in that handy size. During its 23 year run the magazine contained the illustrations of Mervyn Peake, Eric Fraser, Frank Bellamy (of Dan Dare fame) and, perhaps most famously, Ronald Searles cartoon series St. Trinians.
Sheppard was one of the most
prominent illustrators of his generation working for comics such as Eagle, Girl, and Swift, and magazines such as Boys Own
Paper, Lilliput, Everbodys, Picture Post, and Reynolds News.
Raymond Sheppard; Artist in water-colour, black and white, oil, pastel;
Born London 3 March 1913; son of Edward and Annie Sheppard.
Married Iris Gale on December 3rd 1942; had one daughter Christine born 17 March 1944, and one son Michael born 25th July 1946. Educated Christs College, Finchley, north west London.
Studied art at Bolt Court under S.G. Boxsius.
Exhibited: R.A; R.I; R.S.A; Work reproduced regularly in publications including Lilliput ; The Studio, Picture Post, John Bull, Everybodys ; in childrens books, nature books and calendars.
Raymond Sheppard produced many studies of birds and animals from life, mainly at Regents Park Zoo and was made a Fellow of the Zoological Society in 1949. He also painted landscapes, family portraits, in watercolour, oil, and pastels . He was a founder member of the Wapping Arts Group, a group of artists who sketched and painted by and around the river Thames in London, which was formed just before WW2 but did not start in earnest until 1946.
Publications: How to Draw Birds (first published by Studio in 1940), Drawing at the Zoo (1949 Studio), More Birds to Draw (Studio 1956).
Lived in Kenton and then Harrow Weald, Middx.
Clubs: Chelsea Arts, Langham Sketch.
Raymond Sheppard died in London of cancer in 1958 with which he had battled since 1949. He also served in the RAF photographic section during the WW2. Despite long periods of ill health and the interruption of the War years he was, nevertheless, prolific in demonstrating his wide range of artistic ability as a master draughtsman, illustrator, and landscape and wildlife artist..
Had Raymond Sheppard lived beyond his mid 40s his reputation
as one of the foremost illustrators of his generation might have
been secured his premature death resulted in his name sinking
into obscurity for half a century.
Only his prolific career as an illustrator (nearly 100 childrens
books in the single decade following the end of WW2) has prevented
his name from disappearing altogether and secured him a
credible place in the standard reference works of the period. What
has never been appreciated before is the remarkable diversity of
Raymond Sheppards oeuvre. Aside from his more familiar studies
of wildlife his studio has revealed a series of remarkable portraits,
thrilling boys-own period illustrations, plein air seascapes,
landscapes, views of the Thames and surreal compositions, which
at times verge on abstraction. All have in common Sheppards
stated aim to express his inner emotion:
...that peculiar, unexplainable tightening inside that makes you
want to laugh sometimes, sometimes to sing and dance for joy, and
sometimes just a little sad.
To read the full text, download the catalogue here :


text:
How many times throughout the day have you taken notice to some form of pain, suffering, chaos, conflict or any other annoying activities? You may notice this either in your outer or inner environment, or both. If you do not notice anything at all then I suggest you check your heartbeat because you might be walking dead. For me, there are numerous times throughout the day where I witness and feel the "prick" of the world. Just the other day I was driving in LA; where the traffic, over populat … [Read more...]
Instant Relief with Adam C Hall
August 16, 2013 by Leave a Comment


text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Betaine/γ-aminobutyric acid (GABA) transporter (BGT1, SLC6A12) is a member of the Na+- and Cl−-dependent neurotransmitter transporter gene family with a homology to the GABA transporters (GATs), GAT1 (SLC6A1), GAT2 (SLC6A13) and GAT3 (SLC6A11) (HUGO nomenclature). Since antidepressants have been reported to inhibit GABA uptake, we examined those effects on mouse BGT1 (mBGT1) in comparison with other mouse GAT (mGAT) subtypes in the heterologously expressed cell cultures. All antidepressants tested here inhibited the [3H]GABA uptake through mBGT1 and mGATs in a rank order of potency with mBGT1 > mGAT1-3. Kinetic analyses for maprotilline, mianserine and trimipramine revealed that they inhibited mBGT1 and mGAT1 noncompetitively, except that mianserine competitively inhibited mBGT1. These results provided a clue to investigate the structure-function relationship of mBGT1 using antidepressants as a tool, leading to the identification of potential candidates for selective and specific inhibitors of mBGT1.
Uptake of neurotransmitters through the plasma membrane transporter is a primary mechanism regulating extracellular neurotransmitter concentrations, thereby play a key role in the control of synaptic neurotransmission [
Since GABA is the major inhibitory neurotransmitter in the mammalian central nervous system, GATs could be an attractive target for therapy of CNS disorders associated with GABAergic system, such as epilepsy and neuropathic pain [
Tricyclic antidepressants (TCAs), known as the inhibitors of monoamine neurotransmitter transporters, especially transporters for serotonin (SERT) and noradrenaline (NET) [
Recent success of X-ray crystallography of leucine transporter (LeuT), a bacterial homolog of mammalian Na+- and Cl−-dependent neurotransmitter transporter [
In the present study, we addressed this issue by analyzing the potency of various TCA in inhibiting mBGT1 in comparison with other GAT subtypes using [3H]GABA uptake assays in the cell cultures heterologously expressing mouse GAT subtypes. Further, we selected three atypical TCAs to evaluate the mode of inhibition by examining the kinetics of transport.
To analyze the effects of inhibitor candidates including antidepressants on the uptake of [3H]GABA, we established cell lines stably expressing GATs using CHO cells. Those were designated CHO/mGAT1, CHO/mGAT2, CHO/mGAT3 and CHO/mBGT1. Nomenclature of GAT subtypes accords to HUGO. Mouse GAT2 designated in the first report [
Using these cell lines together with CHO cells stably expressing rat SERT [
According to the correlation analyses, potency of TCAs tested in inhibiting mBGT1 as well as mGATs correlated well with that in inhibiting rSERT, except maprotiline, mianserine and trimipramine, which revealed weak potency to inhibit SERT (
Since all the antidepressants are known to inhibit monoamine transporter competitively [
BGT1 (SLC6A12) is a member of the Na+- and Cl−-dependent neurotransmitter transporter gene family with a high homology to the GATs, GAT1 (SLC6A1), GAT2 (SLC6A13) and GAT3 (SLC6A11) (HUGO nomenclature), and reveals GABA transport activity. However, role of BGT1 in the brain remains obscure. Since TCAs have been reported to inhibit GABA uptake [
The present results confirmed the previous observations demonstrating the inhibition of GATs by TCAs [
There are several differences between the results observed by Nakashita
Another possibility is the difference of GATs used, such as Nakashita used rat GATs while we used mouse GATs. Amino acid sequences of these GAT subtypes display high homology between mouse and rat. Recent success of X-ray crystallography of leucine transporter (LeuT), a bacterial homolog of mammalian Na+- and Cl−-dependent neurotransmitter transporter [
In addition, the present results suggest the candidate amino acids interacting with TCA, which may result in the different sensitivity to TCA between mBGT1 and mGAT1. There are three different parts involved in the interaction with substrates (central and second substrate binding sites) and antidepressants (extracellular vestibule), as indicated previously [
Since it is suggested that BGT1 plays a role in regulating GABAergic activity in CNS, development of selective and specific inhibitor of BGT1 has a clinical importance [
Drugs used were: cocaine hydrochloride (Takeda Chemical Industries, Ltd., Osaka, Japan), 5-HT, pargyline hydrochloride (Nakalai Tesque, Kyoto, Japan), paroxetine (Tronto Research Chemicals Inc., North York, ON, Canada), amitriptyline, amoxapine, clomipramine, maprotiline, mianserine, nortriptyline, doxepin, protriptyline, trimipramine, zimelidine (Sigma-Aldrich Co., St. Louis, MO, USA), desipramine, imipramine, (Wako Pure Chemical Industry Co. Ltd., Tokyo, Japan). RivatraAce, KOD-plus DNA polymerase from TOYOBO (Tokyo, Japan), restriction emzymes from New England Biolabs (Beverly, MA, USA), DNA purification kits from Qiagen (Hilden, Germany), transfection reagent FuGENE6 from Roche Diagnostics (Mannheim, Germany), reagents for cell culture from Sigma and Invitrogen (Carlsbad, CA, USA).
[3H]GABA (0.87 TBq/mmol) and [3H]5-HT (1.11 TBq/mmol) were purchased from NEN Life Science Products, Inc. (Boston, MA, USA).
mGAT1 cDNA(4.2 kb) in pBluescript II has been cloned previously [
mGAT2 (clone ID; C730037J22) and mGAT3 (clone ID; B730043P22) cDNAs from RIKEN Mouse FANTOM Clones were obtained through KK DANAFORM (Yokohama, Japan) [
mBGT1 was purchased from Origene Technologies, Inc. (Rockville, MD, USA), and subcloned into pcDNA3 at KpnI/XbaI site.
Rat SERT (rSERT) cDNA used as a control has been cloned previously [
COS cells were maintained in high glucose Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal calf serum, 100 units/mL penicillin-G, 100 μg/mL streptomycin and 2.5 μg/mL fungizone at 37 °C under 5% CO2/95% air. CHO cells were cultivated in alpha-minimum essential medium (α-MEM), supplemented with 10% fetal calf serum, 100 units/mL penicillin-G, 100 μg/mL streptomycin and 2.5 μg/mL fungizone at 37 °C under 5% CO2/95% air.
For uptake assays in cell lines stably expressing mouse GATs, CHO cells were transfected with cDNA using FuGENE6 transfection reagent according to the manufacturer's directions, and subsequently cultured in the medium containing G418 to select positive clones. CHO cells stably expressing rat SERT have been made previously [
For transient expression experiments, COS-7 cells at subconfluence were harvested and transfected with cDNA of GATs by electroporation [
Cells were washed three times with oxygenated Krebs Ringer HEPES-buffered solution (KRH; 125 mM NaCl, 5.2 mM KCl, 1.2 mM CaCl2, 1.4 mM MgSO4, 1.2 mM KH2PO4, 5 mM glucose, and 20 mM HEPES, pH 7.3) and incubated for 10 min at 37 °C with 10 nM [3H]GABA or other radio-labeled ligands, as described previously [
Data were analyzed by Eadie-Hofstee plots using Prism 5 (GraphPad Software, Inc., San Diego, CA, USA). Statistical analyses were performed using the analysis of variance (ANOVA) with pairwise comparison by the Scheffe method and the Student's
All antidepressants tested here inhibited the [3H]GABA uptake through mBGT1 and mGATs in a rank order of potency with mBGT1 > mGAT1-3. Kinetic analyses for maprotilline, mianserine and trimipramine revealed that they inhibited mBGT1 and mGAT1 noncompetitively, except that mianserine competitively inhibited mBGT1. Based on the LeuT structure, the results from the present study focused several residues responsible for the difference of the sensitivity not only to the substrate transport but also to the antidepressant interaction. The finding that mianserine revealed a competitive inhibition of mBGT1 but noncompetitive inhibition of mGAT1 provided a clue to investigate the structure-function relationship of BGT1, which might lead to the development of potential candidates for selective and specific BGT1 inhibitors.
This study was supported in part by a Grant-in-Aid for Scientific program from the Japanese Ministry of Education, Culture, Science, Sports and Technology (NS and SK).
Kinetic analysis of the effects of antidepressants on the [3H]GABA uptake in COS cells transiently expressing mouse (m)GAT1 (
Comparison of the inhibitory action of antidepressants on mouse γ-aminobutyric acid (GABA) transporter subtypes and rat serotonin transporter (SERT). CHO cells stably expressing mouse GABA transporter (GAT) subtypes and rat SERT were incubated with 10 nM [3H]GABA or 10 nM [3H]5-HT for 10 min in the absence or presence of various concentrations of antidepressants tested. Values for mGAT1 and mBGT1 represent the mean ± SEM for three–four experiments each performed in triplicate, and the data were analyzed statistically.
|IC50 (μM)
|33.0 ± 9.9
|100.6 ± 11.7
|78.3 ± 9.5
|287.9 ± 80.5
|27.2 ± 6.1
|93.3 ± 39.8
|75.3 ± 6.3
|268.4 ± 36.7
|59.9 ± 11.2
|222.1 ± 14.7
|44.5 ± 2.2
|222.5 ± 58.5
|61.3 ± 2.1
|123.5 ± 8.4
|57.4 ± 3.9
|221.6 ± 9.9
|47.0 ± 2.1
|135.7 ± 21.9
|43.6 ± 10.2
|166.8 ± 22.1
|21.8 ± 3.8
|181.4 ± 72.9
Data for mGAT2, mGAT3, and rSERT represent IC50 values from single experiment or the mean values from two experiments.
Changes in the GABA transport kinetics induced by antidepressants in COS-7 cells expressing mGAT1 and mBGT1. Cells were incubated with 20 nM [3H]GABA in the absence (open circle) or presence of maprotilline (100 μM for mGAT1 and 60 μM for mBGT1), mianserine (200 μM for mGAT1 and 20 μM for mBGT1), and trimipramine (100 μM for mGAT1 and 20 μM for mBGT1). Nonspecific uptake was determined in the presence of 10 mM GABA. Values represent mean ± SEM of four experiments each performed in duplicate.
|13.04 ± 1.87
|9.38 ± 2.44
|0.48 ± 0.04
|9.93 ± 2.67
|0.47 ± 0.04
|9.33 ± 2.39
|0.37 ± 0.05
|202.2 ± 34.8
|242.7 ± 56.2
|0.47 ± 0.06
|305.2 ± 56.4
|0.90 ± 0.03
|254.9 ± 34.4
|0.86 ± 0.06


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Country Quickie: Swift & Styles Tattooin', CMA Country Christmas Special & More…..
Time for your daily dose of Taylor Swift! According to MTV News, T-Swift joined her 18-year-old boy toy, Harry Styles as he inked up his arm at the
Shamrock Tattoo Parlor in L.A.. You can see a picture of the giant pirate ship tattoo right here.
-The CMA Country Christmas special airs tonight at 9p on ABC. Sugarland's Jennifer Nettles hosts the show. Performing are….Dierks Bentley, Keith Urban, The Band Perry, Martina McBride and more…
-Miranda Lambert is scheduled to be a guest judge on Lifetime's reality show "Project Runway."
-Kenny Chesney played an acoustic show last night at the Key West Margaritaville. Chesney was joined by Mac McAnally and Keith Gattis. Gattis wrote "El Cerrito Place" and McAnally wrote "Down The Road." By the way, it was a FREE show!


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Honors Study Abroad
Build Your Own Adventure
Burch Fellowships
Carolina Blue Honors Fellowships
Robinson Honors Fellowships
Weir Fellowships in Beijing and Shanghai
Become fluent in Mandarin and gain practical, independent work experience in China, home to one of the world's oldest civilizations and the 21st century's fastest growing economy.
Weir Fellows spend the Spring semester in Beijing for intensive language study at the CET Chinese Language Center, then complete an eight-week summer internship in either Beijing or Shanghai exploring careers in fields such as banking, law, journalism, public health, and historic preservation.
Singapore: Honors Exchange Program
Honors Carolina students may enroll in the University Scholars Program at the National University of Singapore. Students live in Cinnamon College (an Honors residence), take Honors seminars, and participate in a wide range of co-curricular and social events with their Singaporean classmates.
This program is limited to Honors Carolina students.
Honors Public Policy Seminar in Washington DC: Domestic & Global Affairs Internship Program
A unique "study abroad" experience in our nation's capital focusing on public policy. Students engage directly with individuals who influence policy issues and complete an internship at a domestic or global affairs organization.
Burch Field Research Seminars
Winston House
Winston House is Honors Carolina's London home, and serves as a hub for UNC's study abroad programs and research initiatives across Europe.
Honors Study Abroad Scholarships
Students accepted into an Honors Carolina Study Abroad program may apply for scholarships based on demonstrated financial need and academic merit.
Click the "Application for Study Abroad Award" on the application checklist for consideration.
Additional Study Abroad Programs
The UNC Study Abroad Office offers more than 300 programs in 70 countries around the world.
Gina Difino
Director, Burch Programs and Honors Study Abroad
(919) 962-9680
Join Global Honors Listservs
Honors Fellowships
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Our 2012 fave beauty posts
We're throwing ourselves into the new year by celebrating our favourite posts of the past year. A beauty wrap up seemed particularly important, since looking good is a preoccupation for many of us right now. In the southern hemisphere we're hit with the trifecta whammy of New Year, holidays and summertime all at once… no place for flab, crumbly makeup or dull skin, right?
Never fear, if you pop through our fave ten beauty posts below, you're practically guaranteed to have great hair (in a suitably gorgeous up do), great skin (using stuff from your pantry) and great legs… maybe.
Our 10 favourite beauty posts of the year
2012 fave beauty posts
Tips and tricks from working on magazines
Nikki opened up her archives and shared all the good stuff she learned while she was working on mag shoots. From brushing our eyebrows to patting our moisturiser, we're all pros after reading this one.
Pip made us a fancy collection of homemade spa treatments – do you suspect a theme here? We are all about the homemade, easy to access beauty stuff on VV!
Pip rounded up ten cute hairdos that take no time at all and are actually achievable. No more 'signature' scraped back ponytails allowed!
Pip rounded up ten cute hairdos that take no time at all and are actually achievable. No more 'signature' scraped back ponytails allowed!
Out of the ordinary beauty tricks
This post went mental on Pinterest and it's not hard to see why… lots of great advice about using products you already have in ways you never thought could work. You will never look at a tube of toothpaste in quite the same way again.
Emma reveals that revealing skirts need not be our nemesis. From checking our hormones to getting a tan, there are ways to make our legs look more than pasty white and flabbolo.
Emma showed us that no matter our colouring (even we REDHEADS), fuchsia is a shade that will brighten our dial and give us a lift.
Banish dark circles and puffy eyes
Nikki showed us how to get rid of the evidence of living using kit you'll find in your pantry. Big nights out (or nights in with little ones, more like!) are here again!
Katrina reminds us that beauty is just as much how you feel as how you look.
How to make skin scrubs at home
Nikki made us a cute video to show us how to turn our oats and our sea salt into useable beauty scrubs that work. Press play and raid the pantry!


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TOP STORY >>Couple to get a new home
Leader staff writer
Wayne and Wanda Bridges are one Saturday closer to being homeowners thanks to the Lonoke County Habitat for Humanity and its volunteers.
Were so happy. Weve never had a house to call our own before, Wayne Bridges said.
The Bridges hope to move into their new 900-square-foot home by Sept. 1 after 12 Saturdays of Habitat work on the home.
They have to contribute 300 hours of sweat equity themselves, but as Wayne said, We dont mind doing that at all. The five-year Lonoke residents currently live in the Woodlake Apartments and cant wait until they can move into their new home.
Well take good care of it and enjoy it, Wanda Bridges said.
During the first work day volunteers erected all of the exterior wall frames and all but finished the 12 by 12 foot storage building.
Its amazing what can be accomplished in one Saturday when you get so many people together, Mary Anne Taft, president of Lonoke County Habitat for Humanity, said. Termed the Grace House, the property was donated by Rev. Virgil and Lillie Turner. Those volunteering to help build the home are members of area Lonoke County churches.
Its just a bunch of guys and girls from the churches coming together, Mike Hedges, project director, said.
For many of the volunteers, this isnt their first time building a home as most of them have traveled with their church on mission trips to aid others in need. Larry Cagwin from South Bend United Methodist Church has helped on a build in Guatemala as well as worked on an orphanage in Hot Springs.
This is his first time to help with a Habitat home, but got on board when he heard about it at church. This is also Roger Huitts first Habitat home; he is also from South Bend UMC.
Im happy to be here, Huitt said, and to be able to help somebody out and contribute something.
Butch Randolph and his son Aaron were also among those volunteering their time Saturday.
We came out to get some work done and make sure people have a good place to live, Aaron Randolph said. David True and his son John of Cabot came out to try and help those in need of help.
Because the labor is donated, the Bridges will only have to pay in monthly rent the cost to build their new home. Covenant Termite treated the ground before the construction began; electrician Doug Gates is donating his time to wire the home; West Lake Plumbing donated their time to install the water pipes; Gold Heat and Air is donating time to install the heating and air unit for the home. The Cabot Police Department will be installing the roof on the two-bedroom home when the time comes.
Its about building relationships and not just homes, Taft said, adding those who would like to volunteer with Habitat can attend the monthly meetings held at 6:30 p.m. the second Thursday of the month at the accounting office of Shelly Russell, 1904 S. Pine St., Suite E, Cabot.
Once the Bridges home is completed, a second Habitat house will be built at the rear of the property, bringing Lonoke Countys total of Habitat homes to four, two in Lonoke and two in Cabot.


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I see that an all-male court in Iowa has ruled that an employer can fire a woman merely because he finds her attractive. The dentist who fired her argued that he was defending family values because she was a threat to his marriage. It is almost depressing to see here the same problem that Rabbi Joshua of Nazareth preached against 2000 years ago. [Read more…]
Taking Responsibility for Feelings
December 23, 2012 by Leave a Comment


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Seriously, though, go put on a hat. It's crazy cold out there. Image via Big Nose Full Body.
Have a neighborhood photo to share? Send it to firstname.lastname@example.com, add it to the South Slope News Flickr Group, or tag it #southslope on Instagram, and we'll post it to the site.


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16 U.S. Code § 4262 - Purposes
§ 4262.
PurposesThe purposes of this chapter are the following:
To assist in the conservation and protection of Asian elephants by supporting the conservation programs of Asian elephant range states and the CITES Secretariat.
(Pub. L. 105–96, § 3, Nov. 19, 1997, 111 Stat. 2150.)
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text: Submitted by brad.cruickshank on Thu, 2014-06-19 07:34 Upper Chattahoochee Chapter - 436 Vote Up Down +43 + Clem and me.JPG Fellow UCCTU members: I have just returned from an annual 8 day fly-in canoe/camping/fishing trip to Woodland Provincial Park in northern Ontario. The Red Lake Super-8 lobby was full of other fisherman either preparing to fly into camps or coming out. The scene could easily have been the lounge of an assisted living facility; only gray hairs (I like to think "silverback" as in gorilla troops). Saturday, June 21 UCCTU will participate in one of our major conservation activities; stream restoration of Pretty Branch. We do a good job with conservation. But my Red Lake, Ontario experience emphasized another important area in which we must do better. Nothing I write here is meant to denigrate the good hard work of Education Chair Jim Harvey and his volunteers. But without expanding our influence on boys and girls/young men and women, all that we do here at TU can be lost in a lifetime. I know I don't need to explain the competition we have for kids' attention. We have a very good UCCTU Chapter. But we are "playing it safe". I will be lobbying our Chapter Board to more aggressively fund our youth education activities. We need to insure that we get kids the experience of catching a trout. We need to infect them with fly fishing even if we have to give them a rig, a hot dog lunch, certificates, pins, hats, an awards dinner; whatever it takes to implant an experience that can shape a lifetime. What does this mean for you? It means that we will need more money to make this happen; money for a specific purpose; not for a rainy day, or for bank charges, or internet fees, or other expenses an organization incurs; but money to invest in changing lives. Voluntary dues, our rod raffle, Film Tour/Autumn auction and activities not even yet thought of, will become critical to making this happen. I welcome your feedback and look forward to your support, email@example.com. Brad Log in or register to post comments


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Summit County Developmental Disabilities Board (Summit DD) invites local families to its second Family Movie Night on Thursday, July 17. The Lego Movie will be shown at the Administration Building, located at 89 E. Howe Road in Tallmadge at 6 p.m. Gates open at 5:00 p.m. This event is free and open to the public.
"The hope for these events is to build parent-to-parent connections where families can network and get to know friends from their community. That's how we make more inclusive places for everyone," explained Summit DD's Early Intervention Manager, Tina Overturf.
This second event builds off of the success from the initial Family Movie Night in May, which provided children and families of all abilities the opportunity to meet and mingle. "When I looked across the playground at all of the kids playing, I didn't see any differences. I didn't see kids with disabilities and kids without disabilities. I just saw families having a great time together – and that was the point of it all. That's what successful inclusion is," Overturf shared.
In addition to the movie and playground fun, kids will also have the opportunity to play the new Lego Movie Xbox game, compliments of the Beechwood Microsoft store. "We want to thank our partners at Microsoft, who will be joining us," Overturf added. "Like us, they see themselves as part of the community and look for ways to support the community around them."
Families are encouraged to bring chairs or blankets for the movie. Adaptable seating is available for use. Please contact Summit DD's Children's Services department with special requests prior to Thursday, July 17. Food and non-alcoholic beverages are permitted. Popcorn will be provided. Additional information is available online at SummitDD.org/Events. For questions, please call Summit DD's Children's Services department at 330-634-8611.
The Summit County Developmental Disabilities Board, or Summit DD, is a levy-funded community resource that provides services to more than 4,000 people with developmental disabilities and their families in Summit County. It is the organization's mission to offer a lifetime of services and supports to eligible individuals and families that empower people with developmental disabilities to work, live, and learn as equal citizens in their communities. More information regarding the agency is available online at SummitDD.org.


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"The Lutheran maxim that the finite bears the infinite (finitum capax infiniti) is an incarnational and sacramental summary of this good news. Indeed the good news of Christmas is that the Word is born into the flesh of all creation." This statement frames my answer to the latest #progGOD question: Why an Incarnation? What does [Read More…]
Why Incarnation?
December 5, 2012 by Leave a Comment


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Hello, I am looking for a new housemate to move in from July/August. One of my housemates is moving away. I am looking for someone to take over their room and share of outgoings/rent. We share a Large house with lots of space. Tiled outdoor living area great for the Innisfail Summer with pool and large backyard. Air-con and fans in all rooms. Mostly furnished house. Two existing clean and tidy professional flat mates, one male one female. $135 pw + outgoings. Located in Belvedere QLD 4860 Message me for further details
It is a nice pole home polished floors ,pool ,amazing view overlooking bingil bay its a 5 min walk to beach & cafe and the local shuttle bus stop is 50 meters away neighbours are cool but not close the house has dishwasher gas stove air con fans all furniture is supplied the room needs a new Bed witch I will purchase if applicant doesn't have furniture the house has ample storage space pool maintaince and power is included there is a separate toilet on lower level bathroom is 6mnths since refit new bath shower
Large room Outdoor undercover area Quiet street Friendly neighbourhood Bbq area Close to shops and bus stop
Very neat and tiidy house with a very large pool on a large block , quite street . All rooms with aircon and ceiling fans . Full size slate 8 ball table . Shedfor storage if needed , BBQ and WIFI .


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Separate names with a comma.
Discussion in 'General Discussion' started by Bobitis, Feb 12, 2010.
Doesn't seem so bad.......
still feels like general discussion so far...
Ok then....
The pot has been stirred, and much to the suprise of the many of us, nothing has changed.
I jumped to conclusions as did many of us.
Time out. Peace. Collect thoughts. STEP AWAY FROM THE FORUM!
Breathe. Relax. Try to understand.
I'm guilty. My humble appologies.
You can not imagine the enjoyment I have had participating in TFF. As a relative newbe I am still some what intimidated making a post due to limited computer skills, inexperience and ignorance. I would not want to make problems for any of the staff but may well do that innocently. I would not be offended or embarrassed after making a post if one of the more senior members pointed out to me the errors I was making so that I could correct them and not continue to make problems for others. I would think most new comers would feel the same way. Tactful corrective criticism should be acceptable to all ( even 71 year olds ).
Yep....same thing. Same stuff can be posted in "Off Topic" that was posted in "General Discussion".....and people will still put posts in the wrong area. Edited for bathroom type content I'm just not sure this will solve anything. Kind of like the Democrates renaming the same bill to a different name.
Chief, as many lives as you have saved and your career of being a public servant, absolves you of any errors you think you may have made here. Thank you for your service. I would be proud to be your friend. May you stay and teach us about life, for many years to come.
better wait and see Bobbis......remember the idea is two fold...it is not as simple as renaming "General Discussion" to "Off Topic"....the Mods do not want discussion other that about firearms.
And, it's not even the 1st of April.
OK then.....
You may most certainly consider yourself my friend. At the risk of thread drift, if you want to be really friendly you would send some of that Florida weather up this way. I am way past accepting this snow. I have all the brass loaded except for some primed .38 Super because I no longer have the pistol. I just want to get out and shoot something.
Friendship humbly accepted. Stop into the Red Dog Saloon or the Harem thread (now the TFF Cole), anytime.
The high here tomorrow is 49 with 15-20 MPH winds. Cold day for baseball practice. At least the kids can run.
Having general chat deleted and removed from this earth had me shaking in my boots! and to think I was looking for another forum!
If it had been deleted than I think I would have lost all faith in people! no no wait to think about it people kind of suck in general but you guys are OK!
Says who? I never read anywhere that off topic can only be about firearms.....
Much like "some" preachers... i think you are interpreting things your own way?
My suspicion is that they just want the childish stuff to cease.
I sense a great deal of fear and trepidation about... we know not.
Is that the problem? We know not? Change?
My humble suggestion is that we all take a deep breath, kick back and open another beer... or whatever. We can afford to wait and take note of what transpires. Then we can congratulate or complain depending on how we feel about the forthcoming "changes".


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»M.S. in Data Science
» Course Offerings
One unit of credit equals four semester hours.
MDS 523 Data Warehousing
.75 credit
Topics include an integrated and detailed comparison of relational, hierarchical and network database systems. Database design and physical storage requirements, including distributed database design and related management issues, are discussed. High-level query languages using artificial intelligence techniques are reviewed along with other topics such as database compression, encryption and security.
MDS 534 Data Mining and Business Intelligence
.75 credit
Business intelligence represents a conceptual framework for decision support. It combines analytics, data warehouses, applications and methodologies to facilitate the transformation of data into meaningful and functional information. The major objective of business intelligence is to enhance the decision-making process at all levels of management. Data mining is a process that utilizes statistical analysis, probability theory, mathematical modeling, artificial intelligence and machine learning techniques to extract useful information and subsequent knowledge from large data repositories, commonly referred to as "big data." This course examines a number of emerging methods proven to be of value in recognizing patterns and making predictions from an applications perspective. Students will be provided the opportunity for hands-on experimentation using software and case studies.
MDS 535 Programming Languages and Environments
.75 credit
This course covers the application of appropriate high-level programming languages for expressing software design patterns used for extracting and processing big data. These high-level languages include Hadoop, Python and R, along with the associated libraries and language pragmatics for framework and patterns (e.g. map-reduce) relevant to processing massive amounts of data. Query languages, spreadsheet macro languages and web-client scripting languages are also studied in the context of data mining.
MDS 546 Quantitative Methods
.75 credit
The ability to move data along the continuum from information to insight to action requires a strong foundation of skills in various quantitative methods. This course begins with a systematic and integrated overview of concepts from probability theory, statistics and mathematical modeling such as probability distributions, cumulative probability distributions, descriptive statistics, hypothesis testing, correlation analysis, linear regression, multivariate regression and mathematical model design. The course then proceeds to examine modern tools for conducting analyses using these quantitative methods on both small-scale and large-scale datasets. Case studies from a variety of settings are used to develop students' abilities to successfully apply the techniques learned in this course to practical circumstances that often, because of the ambiguities involved, present limitations to the power of these mathematical tools. Topics from this course also provide the foundation for some subjects covered in the analytical methods course and the data mining and business intelligence course.
MDS 549 Data Mining Project
.75 credit
Each student completes a project incorporating the practical application of several of the program's data mining techniques to one or more data sets chosen by the student or provided by the instructor. In addition to the correct use of the techniques and interpretation of the results, emphasis is placed on the student's ability to gauge the resultant impact on the organization's business intelligence processes and procedures. Prior to the submission of the final project, students submit a proposal describing the application and the data mining tools to be utilized.
MDS 556 Analytical Methods
.75 credit
This course builds upon the foundation established in the quantitative methods course to develop the advanced analytical methods required for in-depth applications of data science. Topics covered include advanced techniques in statistics and mathematical modeling such as exploratory data analysis, logistic regression and stochastic models; modern techniques for network analysis such as measures of network centrality, hierarchical and other clustering techniques, and models of network growth; and special topics drawn from subjects such as graph theory, game theory and linear algebra. Techniques for visual presentation of data analysis will also be covered. Course topics will be introduced from both a theoretical framework and through the use of case studies in applied settings.
MDS 560 Business Intelligence for Enterprise Value (for Graduate Certificate in Entperise Optimization program)
This course provides a business-oriented framework for the data scientist to identify, prioritize and perform data analytical projects that drive business value and enhance competitive advantage. The course examines the data ecosystem, both external and internal to the enterprise, as well as business processes and networks upon which analytical projects can be used to reduce organizational risk and drive the creation of economic value. Topics covered include: marketing, sales and customer data exploration, supply chain data exploration, operations data exploration, financial data exploration and project management methods to convert information gain into business value. A variety of business process data sets will be examined using analytical tools including Tableau, SAP Predictive Analytics, and IBM Watson. Students will conduct the steps of an analytical workflow on a selected business process and create a project plan to drive value.
MDS 564 Advanced Data Mining and Analytics
.75 credit
This course emphasizes the application of the primary topics covered in MDS 534 Data Mining and Business Intelligence and MDS 556 Analytical Methods within large case studies while learning to choose the appropriate programming language(s), software design pattern(s), and/or software tools, which are covered in CS 535 Programming Models and Environments. In these case studies students utilize data mining tools where appropriate and utilize advanced techniques in statistics and mathematical modeling for supporting conclusions and decisions. Students utilize software tools to visually present conclusions and decisions. Case studies are chosen from a wide spectrum of problem domains.
MDS 576 Research Methods in Data Science
.75 credit
This course serves as the capstone for the program. Students will apply concepts learned and skills developed in the other required courses to complete a major project that demonstrates the full range of their data science knowledge and capabilities.
Students must complete two graduate-level electives from Elmhurst College.
Elmhurst College reserves the right to modify courses, schedules and program format without advance notice to students.
Elmhurst College • 190 Prospect Avenue • Elmhurst, Illinois 60126-3296 • (630) 279-4100
Undergraduate Admission • (630) 617-3400 • (800) 697-1871 • firstname.lastname@example.com
School for Professional Studies • (630) 617-3300 • (800) 581-4723 • firstname.lastname@example.com
Elmhurst Learning and Success Academy Admission • (630) 617-3752 • email@example.com


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Twenty-eight staff positions will be cut at the NFSA and the regular screenings at ARC Cinema will be a thing of the past, following a major restructure announced on Friday.
Chief executive Michael Loebenstein said staff numbers would cut from 206 staff to 178 staff across the archive's four Australian offices, although the bulk are in Canberra.
Do you know more? Send your confidential tips to email@example.com.
And the regular year-long program of films at the heritage-listed cinema will be cut to occasional event screenings and public programs.
Mr Loebenstein admitted that the arrival on the market of Palace Cinemas in the New Acton precinct had made it harder to justify spending taxpayer funds on importing international films and securing quality prints to screen to the public.
He made the announcement at an all-staff meeting on Friday, although he said every affected staff member had already been informed of the changes individually.
More to come.


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Since 1947
(based on 45 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
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of respondents would recommend this to a friend.
Best Uses
Reviewed by 45 customers
Displaying reviews 1-10
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Excellent product.
By Pinky
from St. Peter's, Mo
Comments about Large Print Check Register:
This was a gift for my sisters with poor eyesight. They really liked them.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
By rmw
from wv
About Me Budget Shopper
I can finally see to reconcile my checking account. A little flimsy, but has plenty of pages & good print quality. Will buy again.
(1 of 1 customers found this review helpful)
Wonderful for those of us who have poor eyesight
By BB
from Tennessee
I order from you often and am always pleased with my purchase.
(2 of 2 customers found this review helpful)
Not enough pages
By Dallas
from Virginia Beach, VA
I need a large check register because I can no longer write small enough to use the small ones. I really wish the register had more pages. At this rate I'll be using a new register every couple of months.
Large print is great for old eyes.
By Tater
from Mathews, Virginia
I bought 4 of these for my 94-year-old mother-in-law whose vision is not as good as it used to be. The bigger spaces and print help her a lot.
So much better than the bank issued register
By GramTo6
from Memphis, TN
I bought this giant check register for my elderly mother who still wants to keep her own checkbook but has difficulty writing in the small spaces. The giant register allows her all the room she needs for entries, but also enough room for mistakes and corrections. She is delighted with this.
I always buy this product.
By Ginny
from Hickory,NC
Love this big check register.
Large print check register
By Me
from Antioch, Ca.
Very good product!
By Bob
from Marion, ohio
About Me Midrange Shopper
My husband needs it.
I had bought this product before and will again!
By Ms. Efficient
from Smyrna, GA
As a retiree, I pay my bills twice a month. Using the check register helps me tremendously in keeping my account balanced, especially with the large print. My first one lasted from January, 2015 until October, 2016. I immediately got a replacement and will continue to do so. Very handy indeed!


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Selected Community Events
FHN Festival of Trees: Holiday Movie Series
Nov 17, 2012 - Dec 15, 2012 10 a.m.
Classic Cinemas Lindo Theatre in Freeport IL
'Tis the season again for holiday cheer! FHN is proud to offer a full slate of fun activities for the whole family this holiday season. Welcome to the FHN Festival of Trees 2012!
This year's festivities begin Saturday, Nov. 17 with the kick-off of our popular Holiday Movie Series hosted by FHN and Classic Cinemas Lindo Theatre. Movies begin at 10 a.m. each Saturday through Dec. 15. Admission is just $3.50 and all children attending will receive a holiday gift. Seating is limited, and there are no advance ticket sales, so plan to get there early!
This year's movies are:
Nov. 17 – Wreck-It Ralph
Nov. 24 – The Grinch (free)
Dec. 1 – Rise of the Guardians
Dec. 8 – Dino Time
Dec. 15 – The Hobbit: An Unexpected Journey
For more information on any FHN Festival of Trees event, visit www.fhn.org.


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Ewen Bremner Boards Snow Piercer
He's on for the thriller
It's been nearly a month since we heard about someone joining the cast of Bong Joon-Ho's snowpocalyptic thriller Snow Piercer, but while it looked like he had found his cast, it turns out he's still adding folk: Ewen Bremner is getting his ticket punched for the film.
He's joining a healthy ensemble that already includes Chris Evans, Tilda Swinton, Jamie Bell and newly minted Oscar winner Octavia Spencer.
Snow Piercer, which Bong co-wrote with producer Park Chan-Wook, is set in a world where the Earth is almost completely covered in the frosty white stuff after some badly misjudged climate experiments. Most of humanity survives by riding the titular train, which is powered by a perpetual motion machine. And is fortunately not operated by any British rail company, or it would be a very short film.
Despite the need to survive, old class divides remain in place, and we don't just mean those who get access to a trolley full of packets of Monster Munch and those who have to make their way to the galley. There are even worse problems to contend with: Evans is playing a man looking to rescue his kidnapped son and Bremner will be a father who offers to help.
Bong will kick off shooting this March in Prague. Bremner was last seen alongside his old Trainspotting mucker Ewan McGregor in Perfect Sense and will crop up in both Mike Newell's Great Expectations (out later this year) and Jack The Giant Killer (shoved to 2013).


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Mark Wagh and Ali Brown were the only batsmen to reach double figures in an alarming first innings collapse that has put Nottinghamshire on the back foot against Yorkshire.
Paul Franks, Samit Patel, Chris Read, Steven Mullaney and Darren Pattinson failed to score on a greenish pitch gratefully exploited by Ajmal Shahzad (4-21), Oliver Hannon-Dalby (4-18) and 18 year old LV= County Championship debutant Moin Ashraf (2-11).
Having lost the toss, Notts openers Franks and Alex Hales were charged with establishing a platform but played loose shots to edge Shahzad to Jonathan Bairstow and Adil Rashid respectively.
Ashraf quickly found his line and late swing to clip Voges' off-stump as Notts looked to Mark Wagh and Ali Brown to rebuild the innings. The poor showing continued though as Brown was trapped leg-before by Hannon-Dalby to limt the partnership to 23.
Wagh was unbeaten at 20 at lunch having watched Chris Read fall leg before from the final ball of the morning session but fell shortly after the resumption for 22. Mullaney had already given Hannon-Dalby a third lbw dismissal having suffered a fourth-ball duck.
The total of 59 represents Nottinghamshire's lowest championship innings at Trent Bridge since the visit of Middlesex in 1977.
Yorkshire made a reasonable start to their reply in reaching 60-3 after 17 overs. Andre Adams struck twice in two balls to induce Lyth and Rudolph to edge their shots to a slip cordon in which he himself prospered, holding Anthony McGrath off the bowling of Paul Franks.
Adams finished with 4-82 to cement his position as the league's leading wicket taker but Andrew Gale will resume unbeaten on 147 having led his side to 260-8 at the close.
The Yorkshire captain batted superbly to hammer home the advantage and would later comment that the achievement ranked as his finest day in county cricket.
Notts have a lot to do to prevent a Yorkshire victory that would throw the title race wide open.


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So what causes Penile Cancer ?
At the present, there are no known causes of Penile Cancer but there are RISK factors.
Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. People who think they may be at risk should discuss this with their doctor.
Human papillomavirus infection may increase the risk of developing penile cancer.
Circumcision may help prevent infection with the human papillomavirus (HPV). A circumcision is an operation in which the doctor removes part or all of the foreskin from the penis. Many boys are circumcised shortly after birth. Men who were not circumcised at birth may have a higher risk of developing penile cancer.
Other risk factors for penile cancer include the following:


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Late last year a few polls revealed that Americans' trust in their government leaders had fallen to
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When Games Matter is a weekly exploration by Drew Dixon of meaningful moments in games. Operating under the assumption that games do in fact matter, Drew seeks to highlight those moments that have much to say to say about who we are and the world we live in.The day I found out that I was going to be having a girl was also the day I first played Lucasart's puzzle game, Lucidity. Lucidity centers on a young girl named Sofi and her close relationship with her grandmother and the latter's subse … [Read more...]
When Games Matter: Lucidity, Grief, and My Daughter
March 22, 2011 by Leave a Comment


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"Abacaxi, óleo de coco, camarão, lagosta!" Pineapple, coconut oil, grilled shrimps, lobster. These the main products offered by the noisy and familiar street vendors populating Brazilian beaches and exploring Fortaleza you are bound to experience that. Everything about them … [Read more...]
Mighty Iguazu Waterfalls, a photo journey
These photos were not taken this time I came to Brazil, but as I was perusing among my pictures, I saw this series of shots I had taken one of the last times here and wondered why I hadn't published them already. Iguazu waterfalls, covering the border between three states, … [Read more...]
Dragão do Mar, Fortaleza's center of culture, art and science
Even after getting mugged and deciding I wasn't going back to the beach, I had a quick trip to Fortaleza's cultural pride, the Dragão do Mar, or Sea Dragon, where I always enjoy hanging around and just observe what they have planned for the day. Dragão do Mar, in fact, just … [Read more...]
Mugged in Fortaleza, how a bad experience can spoil your holiday (plus some safety tips!)
On my very second day in Brazil I was mugged in Fortaleza while strolling along one of my favorite beaches, Beira Mar. Before you think "You should have known Brazil is dangerous", let me tell you that yes, I know many Brazilian cities have a very sad record when it comes to … [Read more...]
A trip, a photo – Emcetur, in Fortaleza a better use for a public prison
It does look unusual for a market, but at first sight you probably won't imagine this colonial building was created as the city's public jail, nonetheless. Today Fortaleza's Emcetur - Centro do Turismo, in Rua Senador Pompeu 350, hosts the Museum of Art and Culture of Ceara and a … [Read more...]
Mercado Central, a feast for the eyes in the heart of Fortaleza – A Photo Essay
My stroll around Mercado Central, the essence of Ceara's art and craft in the heart of Fortaleza, right next to Nossa Senhora da Assunção. Rest assured that here you can find literally anything, from food to clothes to shoes to hammocks to kitchen towels. If you … [Read more...]
Museums, legacy and what Fortaleza is not doing to boost its tourism
It was the first thing I wanted to visit and it ended up being the very last one. Hours before leaving, I finally managed to get to Museu do Ceara, Ceara's Museum, in 51 Rua São Paulo in Fortaleza city center, near Praça de Alencar. I usually visit many museums and palaces, … [Read more...]
Loud and proud, meet Fortaleza art and handicraft (VIDEO)
If you go to an art fair in Fortaleza, or in all of Ceara, you will soon notice that everything about it seems to shout. I'm not just referring to the loud music that very likely will spruce the evening up further, but especially to the impressive range of colors improbably … [Read more...]
A maze of cliffs, water springs, white beaches: welcome to Beberibe
I confess, this time I came to Brazil I've been definitely spoiling myself. Every morning is my fixed date with the beach close to where I live, and when I don't go it means I'm hitting the roads to discover yet other natural wonders of this state of Ceara, in the Northeastern … [Read more...]
Madness, bras and the best tribute to José de Alencar
I've already written about the tragic story of Iracema, so yesterday, while I was vagabonding around Fortaleza city center, finding a tribute to the very much cherished writer José de Alencar was a true moment of joy. I would have liked it to be a cozy one, between me and the … [Read more...]


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[Date Index]
[Thread Index]
[Author Index]
Re: Clear["Global'*"] not working in parallel kernels
AnnaDe wrote:
> Hi,
> I'm working on Mathematica 7. I have created new kernels separate to
> the local kernel in order to be able to run several processes
> simultaneously on different processors. It works, in that none of the
> defined values transfer across kernels, but I seem to have lost use
> of Clear["Global'*"] which is a little worrying. Anybody have any
> idea why this has happened and if there's anything I can do to make
> it work again?
It is Clear["Global`*"]
or more simply Clear["`*"]
Note the symbol before the asterisk; it is found in the upper left
corner on most keyboards, and is not the same as '
Helen Read
University of Vermont


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Formal metadata describing these data are available.
Gas hydrate deposits of polar continental shelves are currently believed to be the most vulnerable to climate change (Kvenvolden, 1988). These areally extensive shelves, formerly exposed to very cold surface temperatures (yearly average -10° to -20°C) have been and are being transgressed by a much warmer polar ocean (~0°C). As a result, the polar shelf surface in water depths greater than 5 m, has experienced an approximately 10°C or more temperature increase over the past 10,000 years. Although pressure on shelfal gas hydrate deposits has increased owing to a rise in sea level of about 100 m, this pressure increase which would stabilize the gas hydrate, is more than offset by the large temperature increase that destabilizes the gas hydrate. The amount of methane released by this process has been estimated to be about 4 Tg (1012 grams) year-1 (Kvenvolden, 1991) or about 1% of all current sources of atmospheric methane. If this suggestion and estimate are correct, then escape of methane from gas hydrate deposits of polar continental shelves should be observable. To test this idea, beginning in 1990 we conducted surveys of methane in sediment, water, and ice in an area of the Beaufort Sea continental shelf offshore from the north coast of Alaska. Previously, measurements of atmospheric methane concentrations at Barrow, Alaska, about 200 km NE of the study area, showed a seasonal increase during August through October, perhaps due in part to methane venting from Arctic shelfal waters (figure 1). This report summarizes our data collected from 1990 through 1994.
These data are from Dlugokencky et al. (1994) and can be obtained through anonymous ftp from cdiac.esd.ornl.gov.
In our survey, we measured methane concentration in sea water under the
ice on six primary transects from nearshore to the shelf break at water
depths ranging from 2.5 to 88m from Cape Halkett east to Mikkelsen Bay,
Alaska (figure 2). Other surface water samples were taken at various
locations where water depths ranged from 2 to 20m within the area between
Camden Bay and the Colville River Delta (figure 2). One oceanic surface
water sample was also collected in April 1993 at 72° 38' N. latitude .
The surveys were undertaken during the last week of April and first week
of May 1992, the middle of April 1993, the latter portion of April 1994,
the second week of September 1993, and the later portion of August 1994.
At each station in April and May, a 23-cm diameter hole was drilled
through the 2-m thick first-year ice. Niskin bottles (1.7 l) were
attached at intervals to a line lowered to the seafloor and subsequently
tripped to collect water samples for methane determinations. In September
1993 and August 1994, when no ice was present, a boat was used to transit
to stations. As each Niskin bottle was recovered, 100 cm3 of water was
transferred to a 140 cm3 syringe. A heat lamp to prevent the water from
freezing during April and May surveys. In the laboratory at the end of
each day's field work, 40 cm3 of ultra-pure nitrogen were added to each of
the syringes, and methane was extracted from the water into the nitrogen
at room temperature by shaking the syringe, following a method modified
from McAullife (1971). A portion of the resulting gas mixture was
measured for methane content by gas chromatography. Multiple extractions
were used on several samples to determine an empirical extraction
efficiency coefficient which was utilized with the remainder of the
samples that were extracted only once. Our analyzed gas standard
contained 10 ppm ±2% methane in nitrogen. Duplicate samples were
analyzed for each water depth with an average standard deviation of
±0.6 nM.
CTD (conductivity, temperature, depth) casts were made at each station. CTD data was recorded internally by a Seacat 19 CTD probe made by Sea Bird of Seattle Washington. The data was downloaded onto a computer where it was processed using Seasoft Version 4.016. The sub-programs LOOPEDIT, BINAVE, then DERIVE were utilized to process the raw data. The data were averaged into 0.5m intervals. The upcast and downcast were evaluated, and only one cast is plotted. In general the upcast was used because the sensors showed less fluctuation. The results are plotted for each station and appended with water methane concentrations in Appendix 1.
Digital data from the CTD casts are available online by individual cast as tab-delimited ASCII (plain text) files or in their entirety as a UNIX-style archive (tar format).
The methods utilized to measure nutrients in this study were adapted from older colorimetric procedures and are described in detail by Whitledge and others, (1981). A basic description of each method, conducted on a Technicon Autoanalyzer System, follows.
Phosphate is determined as phosphomolybdic acid which in its reduced form in the presence of antimony has an absorption maximum at 880 nm. The method is basically an automated version of the procedure of Murphy and Riley (1962).
Orthosilicic acid is determined by its reaction with molybdate in aqueous acidic solution to form silicomolybdic acid. In this procedure, which is basically that of Armstrong and others, (1967), stannous chloride is used to reduce silicomolybdic acid to the heteropolic acid which has an absorption maximum at 820 nm.
Nitrite is determined by the Greiss reaction in which sulfanilamide and N-(1-Napthyl)ethylenediamine dihydrochloride react with nitrite in aqueous acidic solution to form an intensely pink diazo dye with an absorption maximum at 540 nm (Bendschneider and Robinson, 1952). Nitrate, after it is reduced to nitrite by passage through a column of copperized cadmium filings, is determined in an identical manner to nitrite (Wood and others 1967). This analysis gives the sum of nitrate + nitrite, and nitrate is determined by difference.
Ammonium is determined by the Berthelot reaction in which hypochlorous acid and phenol react with ammonium in aqueous alkaline solution to form indophenol blue, an intensely blue chromophore with an absorption maximum at 637 nm. The method utilized is a modification of the procedure reported by Slawyk and MacIsaac (1972).
The methane content of sea ice was measured at 51 stations in 1993 and 1994. A 1m long by 7.6 cm diameter ice corer with an extension was used to core through the ice to sea water. The ice core was laid out on the sea ice, measured and cut into 10 cm sections. Selected intervals were chosen, then placed in 1-liter friction sealed cans equipped with 2 septa ports, sealed, and kept frozen. At the field laboratory, each sample was weighed, then the headspace within the can was purged with ultra pure nitrogen for 5 minutes at flow rates exceeding 200 ml/min. Tests on the methane content of the purged headspace with the frozen ice core inside yielded concentrations less than 0.1 ppm. The cans containing ice samples were placed in hot water baths and stabilized at approximately 20° C. Each can was shaken by hand for about 30 seconds to partition the dissolved methane between the water and the nitrogen headspace. Next, a syringe containing 30 ml of ultra pure grade nitrogen was injected into the can, then 30 ml of the resulting mixture of headspace and gas was removed and analyzed for methane content in the same manner as described for sea water samples. The volume of headspace in the can was determined by the weight of the ice sample, assuming that once melted the water occupied a volume of 1 ml/gm.
Sediment samples were taken in May 1992 operating from the ice canopy. A
hole was augured in the ice, through which a 45 x 7.5 cm core barrel with
an auger cutting head was lowered. The core barrel was attached to 1.5-m
long connecting stems in series up to a maximum length of 15.5 m. Once on
the ocean bottom, the core barrel was rotated by hand with the aid of a
T-bar until no further penetration was achieved. Upon retrieval, the
liner containing sediment was extruded onto the ice. The least disturbed
10-cm long (a volume of about 450 ml wet sediment) section of the core was
chosen and placed in a septa-equipped 1-liter sample can. Seawater was
added to the brim of the can, then 200 ml of water was removed, creating a
200 ml headspace. About 2-3 grams of sodium azide was added as a
biocide. The can was sealed, then purged with helium at a flow rate
estimated to be greater then 300 ml/min. for 5 minutes. The samples were
kept frozen until analysis at our Menlo Park laboratories.
Stations in water depths from 2.5 to 88m were established on six north-
south transect lines as shown in figure 2. Three digit, abbreviated
station numbers are shown on the transect lines. Many stations were
reoccupied on subsequent surveys. Each station is given 3 additional
numbers making a total of six digits per station. The first two refer to
the year, the third to the month of sample collection, the fourth to the
transect number, and the last two represent the approximate water depth at
each station. For example, station 925150 can be read as 1992, May,
Transect 1, at 50 meters water depth. When the same station was
reoccupied on a subsequent survey only the first 3 digits change denoting
a different sampling date; i.e., 934150 was completed in April, 1993.
Stations off transect lines are given a 0 in the fourth digit place.
Station locations are available in a table in tab-delimited ASCII, with the station locations encoded as decimal degrees north latitude and west longitude.
Water Methane Concentrations
Water methane concentrations and methane oxidation rates are listed in
Table 1, and are illustrated by graphs of methane vs. water depth at each
transect in Appendix 2. Measurements of methane in ice-covered sea water
were made in May 1992, April 1993, and April 1994. The results are
compared with measurements taken in ice-free water during September 1993
and August 1994.
Analyses of 143 samples from ice-covered waters demonstrate that methane concentrations in the water column are supersaturated with respect to the equilibrium solubility of methane with the atmosphere (~4 nM). Maximum methane concentrations at a given station ranged from 12 to 275 nM and were typically about 15 to 25 nM throughout the water column. The highest methane concentrations were found near the bottom. Maximum methane concentrations are given in map view for each survey in Appendix 3.
Methane concentrations from ice-free water were determined in 103 samples. Maximum methane concentrations at a given station ranged from 5 to 44 nM with one anomalous measurement of 148.6 nM at station 948120, 18m water depth. Anomalous methane concentrations (33.7-94.4 nM) were also observed at this same station, 925120 throughout the water column in May, 1992. Typically, methane concentrations were at a minimum at the surface, remained nearly constant or increased with depth to concentrations ranging from 9 to 56.4 nM, excluding the 148.6 nM anomaly mentioned above. Methane concentrations in the upper 3m of ice-free water never exceeded 18 nM and were commonly between 6 and 14 nM.
A limited number of measurements of the carbon isotopic composition of methane were made at the University of Hawaii. The results shown in Table 1 reveal a wide range of values from -31.1 to -80.5 o/oo.
Methane Oxidation rates were determined in selected samples (Table 1) and are given graphically in Appendix 4. The rates during ice covered times were higher than most measurements made worldwide. In ice free periods measured to date (September, 1993), the oxidation rates were undetectable. Thus a seasonality exists regarding the oxidation of methane by bacteria living in the water column.
Column headings:
Column headings:
We sampled fast ice and seasonal pack ice at 36 locations along the coast from Harrison Bay to Camden Bay in water depths ranging from 1.8 to 57 m. Maximum methane concentrations are given in Appendix 5 and the complete results are listed in Table 3. Methane concentration profiles along transects are given in Appendix 6.
Methane concentration profiles through the ice within the upper 50 cm interval and from water depths less than about 10m contained the highest concentrations of methane (7 to 1260 nM), with typical values of about 30 to 40 nM. In the ice interval from 50 to 200 cm, the methane concentration ranges from 5 to 286 nM, with typical values of about 15 nM.
Ice that formed in water depths greater than 15m shows the same trend of decreasing methane with increasing depth in the ice core; however, the methane concentrations were less varied and were always lower. Within the 0 to 50 cm interval methane concentrations ranged from 8 to 14 nM and from 5 to 14 nM within the 50 to 200 cm interval. Measurements of the carbon isotopic composition of methane in ice are shown in Table 3 and reveal a wide range of values from -52.1 to -83.4 o/oo.
Column headings:
Column headings:
Methane concentrations range from 2.2 to 10.1 ml/l wet sediment. There is no distinctive pattern of methane concentration. However the highest concentrations were recorded within the confines of one mapped shallow gas anomaly. The highest concentrations are found near the Colville River Delta and range from 4.6 to 10.1 ml/l. The lowest concentrations of methane (3.8 and 2.2 ml/l) were found offshore at Weller Bank in clean sand. This low concentration is perhaps the result of methane escaping more readily from the clean sand rather than silt or clay which comprise the bulk content of the rest of the samples.
This report documents the concentrations of methane in sediment, water,
and sea ice in an area of the Beaufort Sea continental shelf offshore
northern Alaska. Data were collected during field surveys conducted from
1990 to 1994. In addition to methane concentrations, information
regarding methane oxidation rates, nutrients, salinity, and temperature
of the water column is also tabulated. In general, more methane is
present in the water when ice forms a seal over the water column than when
ice is absent. Methane is also present in ice often in concentrations
exceeding those in water. Fast ice forming in place over water depths
less than about 10m can contain methane concentrations an order of
magnitude higher than that of the underlying water. Measurements of the
carbon isotopic composition of methane and ice were initiated in 1994 as
an attempt to define the source or sources of methane. These data
represent the first ever collected is such a setting. The data thus far
demonstrate a wide range of values from -31.6 to -83.4 o/oo indicating
that there a may be complex variety of sources.
The project has been conducted in collaboration with the University of
Washington and the University of Hawaii. We thank (1) M.D. Lilley, E.J.
Olson, and E. McLaughlin, School of Oceanography, University of
Washington, for the information on methane concentrations, methane
oxidation rates, and nutrient concentrations in seawater; (2) B.N. Popp,
F. J. Sansone, and T. Rust, SOEST, University of Hawaii, for the isotopic
analyses of methane. We are grateful to (1) P.W. Barnes, U.S. Geological
Survey, for guidence in Arctic operations, and (2) E. Reimnitz for help in
collecting sediment samples for gas analyses. This work is supported by
the USGS Global Change and Climate History Program.
Keith A. Kvenvolden
Mail Stop 999
U.S. Geological Survey
345 Middlefield Road
Menlo Park, CA 94025
Tel: (415) 354-3213
email: firstname.lastname@example.com
Information here is presented as PostScript figures only. The files
include sufficient information to permit printing on any standard
PostScript-compatible device; the maps are also compatible with Adobe
Illustrator version 5.0 for the Macintosh.


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2004 Schedule
2003 Roster
2003 Results
2002 Results
2001 Results
2000 Results
Prospective Athletes
College Lacrosse in the Southwest
History of Southwestern Lacrosse
Hall of Honor
Directions to SU
Lacrosse Home
SU Home
Southwestern hosted one of the best teams in the nation this past Sunday in the University of Texas. With our star middie falling to a recurring injury
in the first quarter, and the absence of our leading scorer, the team had to
once again rely on outstanding goalie play and strong team defense. Though
the final score was 19-3 in favor of Texas (including holding Texas to a
scoreless 3rd quarter), it was a moral victory for our team.
Because of the many injuries we have had early on, coupled with key losses
of experienced players, many of our freshmen, which now comprises over half
of our team, have been forced to play many quality minutes. The game
against Texas was no different. In fact, against Texas, 9 out of the 16
players available were freshmen. Most of the game was spent on our
defensive side of the field, with one Texas offensive push being stalled for
almost four minutes, with over 10 shots, ending with a Texas goal on a
Southwestern man down.
By the second quarter, every middie Southwestern had available to play
except one, was a freshmen new to the game. Our team, though out-manned 16
to 42 on the sideline, played with great tenacity and heart.
With quality playing time early in the season against four good USLIA
opponents, our team is poised to take advantage of games against teams which
we feel we are evenly matched. This weekend is Family Weekend and
Southwestern hosts St. Edward's, new to the league on Saturday at 1p.m. and
Baylor on Sunday at Noon. Our last two games against Baylor have been
decided by one goal in the final minutes. We were fortunate to have won
both games.
One final note regarding Texas Lacrosse: Ranked in the top 15 in the
nation, and
clearly out-manning our young and inexperienced team, Texas is a team with a
lot of class. A game which could have easily seen the score run up for
ranking polls if starters played the entire time, was one, instead of
learning for both teams as Texas allowed many of its reserves to enter
throughout the game. That touch of class will not be forgotten. As our
young team strives to learn fundamentals and team play on the field,
watching Texas was an excellent hands on experience. While Southwestern may
have lost the game, I think both teams and the game of Lacrosse won this
We look forward to the next time we can play Texas, hopefully with more
experience, and more evenly matched.
Back to Men's Schedule/Results (2000)
Back to Men's Lacrosse Home
Back to Lacrosse Home


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Powder Skiing in April?
With great dreams comes great sacrifice is what my dad told me all my life. It sounds inspiring and rings true with much that I do. Unfortunately it no longer works for my lady after seven years of dealing with me 'sacrificing' my home duties for the 'dream' powder days. This is why I have become a regular at Sammy's flowers in NW Portland and Joe's Donuts in Sandy. It allows me to come home with more than a stupid grin on my face from the excitement of the mountain.
The reality is she is very accepting of this passion that skiers and snowboarders share and understands it is a big part of who I am. The best way I can describe a powder morning is that feeling we all have on our birthday morning. Your step is a little bit lighter, everyone seems a bit nicer, and you can do no wrong.
Spring deals at every resort along with a forecast for more snow makes it the best time of the season to hit the slopes. While resorts throughout other states are closing for the season it again shows us why Oregon is so great, powder in April!
Photos were taken at Mount Hood Meadows on April 2, 2009 by Scott Spiker.
Is any of the information on this page incorrect?


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oaknoun [ C or U ]uk /əʊk/ us /oʊk/
B2 a large tree that is common in northern countries, or the hard wood of this tree:
a mighty oak
Thesaurus: synonyms and related words
You can also find related words, phrases, and synonyms in the topics:
(Definition of "oak" from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)
(Definition of "oak" from the Cambridge Academic Content Dictionary © Cambridge University Press)
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Word of the Day
friendly and pleasant to be with


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Main menu:
2011 and 2012 were very different years in the world of rock. 2011 left me wanting for the better part of the year; 2012 on the other hand left me with inner turmoil of which albums would make/be cut from my Top 10 list. It's been an excellent year for music, rock in particular. While only a fraction of the decent rock music on the planet from 2012 found its way to the radio airwaves, there were some real gems that you shouldn't miss.
After a year of spinning every album I could find (Thank you Spotify), I have finally narrowed things down to my ten best of 2012....... (Well, kind of.) Along with my Top 10, you'll also find my commentary on two albums from 2010 that found their way to my speakers in 2012 along with what I consider to be the biggest bomb of the year. The year of the unfufilled Mayan Apocalypse has been a good run, at least if that had come to fruition we would have went out on a high note!
Once you're done browsing our Top 10 Albums list, scroll down to the bottom and crank up some of the top tunes from these albums on our Spotify Playlist and Player.
There were two albums that I somehow missed back in 2010 when they were released, fortunately they found their way to me in 2012. Both of these albums got major airplay in my world throughout the year, I imagine they will be an equally big part of my 2013 rotation as well!
I proudly built Rocksposure under the premise of celebrating what is good about music, not to trash and belittle it. But as I did with my Top Album of the Year, I'm breaking another one of my rules to address my biggest rock dissapointment of 2012.
As you'll see after you click below, while it's a frustration that has been building for a few albums now, it was 2012 that put the nail in the coffin on this artist.