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TTC 10+ months Part 13(999 Posts)
A very friendly and supportive thread for those taking way longer than they had ever expected to make a baby.
X post lemon. I hope becoming increasingly less snotty!
x posts with madness oooh there are so cute little baby stuff to knit, I have knitted a cardigan and several hats and booties, but mainly for my own non existent baby, there is nothing like home knitted items
Hello ladies, sorry to see that the troll has been back to bite again. How very boring A very unfortunate turn of events and another sad day for thread when so many here are struggling with much bigger problems. I hope you're all well and having nice weekends in RL. I'm still here, cheer leading you all on and wanted to say that I think you're all marvellous; kind; generous of spirit; wise; witty; and very decent human beings. I don't understand why a troll is attacking such wonderful individuals who are dealing with such a shitty hand. And I saw Nelly's extension of help on the bump bump bump thread and Sar's lovely words about how helping and being positive is a nicer way of conducting oneself. Well done for dealing with in a very dignified manner, I hope it hasn't caused too much upset, none of you deserve to be personally attacked either . I hope that's that over with for now. I hope the troll doesn't attack any other ladies on any other TTC threads either. Trolls have feelings too but shouldn't lash out or seek pleasure from kind people who just want to help. If you're reading - please leave these ladies in peace and other ladies dealing with this crap too. Big hugs and lots of love to all xxx
WTF has been happening on the Fred today? It makes me I hope all involved are ok. Mumsnet HQ, I assume you've been reading as you deleted buzzy's post... when you see fit to ban someone, do you do it via their email? <scary thought that the person might be setting up faux emails> Once you have banned them, it really should be final. What has happened today is no good for anyone. Some of us on here are having a shitty time and are very vulnerable (as presumably is viv). Please sort it out!
buzz I loved your posts from last night! It's so lovely to see you out and about enjoying yourself. Hope the flowers are looking well nice.
madness pleased to hear you are feeling a bit better. Do you get periods with your drugs or is the whole point that you don't?!
lemon hoping you start to feel better soon. I'm pretty sure my eggs were fried this month too by my flu! How do we hide the fred away?! Is that possible?
grouch your weekend sounds lovely. I've hiked miles today, around Westfield Not so scenic.
euro and doll hope all's going well with you both. Euro has the spotting stopped now?
princess lovely to 'see' you as ever.
sar I'm loving your low key approach to the FET. My period is due any day and then we'll be starting. Like you, I haven't been thinking about it all that much and have drunk far far too much this weekend. I think I'd rather be relaxed and try not to mental too much about it. It's tough trying to maintain the balance of keeping busy and distracted, but giving myself time to rest and some emotional space for it all. I am positive you will get your baby some day. You make such amazing embryos. It's just a matter of time. Hang in their lovely.
Greetings to everyone else. I phone still a bit fooked (nearly cried in apple when they told me it can't be fixed), so it's not easy to scroll back.
We have had a crazy busy, fun weekend, involving a house full and lots of going out. I did have a preg announcement, well not so much of an announcement as a here's my bump, when I saw her, but kinda managed it and tried to banish my barren feelings. Dave's bestie is here from overseas. They've been through 2 unsuccessful ivfs too, so it's been great to be able to talk to him about it all and felt a bit like strength in
barreners no.s, when we met up with friends with kids. I think something that is really difficult aspect of infertility is how isolating it can be. Anyway, I'm off to watch shit tv and maybe have a gin. Hope you are all having nice weekends despite on Fred nastiness.
Woahhhhh. Whilst I have spent the day up to my neck in kitchen DIY, did my attempts to help someone, who seemed very desperate and in need of it, actually make the recipient turn on us . Well I can safely say I've not written words or behaved in a way I wouldn't be happy to do face to face. Wonder if everyone who has
been deleted from written on this thread can say the same.
I will catch up properly later but Sar your words were amazing yesterday, to everyone. You are such a wonderful beautiful person. Everyone on this thread is, I'm not sure why anyone would want to destroy that. Here's the thing. It won't.
Hi all
Well I completely missed all the posts by the Troll Formerly Known As Viv, but having seen her contributions to previous threads I can imagine the kind of content. How unbelievably tedious. I mean, could you be arsed? Shape shifting all the time just to write ranty abuse at a load of strangers who have only ever been nice to you? That's someone with serious problems imo.
Anyway, on to more interesting things. Buzz at the flower theft (and at blaming your friend for getting you drunk). I'm glad they were from a posh bar, for a minute I wondered if you'd been robbing graveyards . Kayla seems impressively omnivorous. Nibbling a biscuit though? Not on!
Rabbit glad you're out of the tent. How do you feel about the IUI + clomid option? I was glad to read your comment about not wanting to make an announcement if diffed. That's just how I feel. I have still only told close family and friends and everyone else can wait. I am sure there'll be a lot of people who will only find out when it's actually born. Those I have told have been . Clearly I have never seemed the maternal type! How is the fur baby? I hope he's improving.
Euro I'm 16 weeks (and still in the fat stage). Those 16 weeks have crawled by unbearably slowly but at the same time I'm amazed and very thankful to have got to this point. Still not taking anything for granted though. I wonder if I ever will.
Mrsden sorry about the announcement and the weird boss behaviour! I would put bets on it not lasting longer than a fortnight.
Madness sorry about the trip to the tent. You've been through absolutely loads and it's not surprising you will feel down sometimes especially with the drugs. But you are on the right track. The ex having children is the pits but as Sar wisely says, you don't want his babies. I'm not in touch with any exes
never been any good at 'amicable' so I'm spared that knowledge but i bet there will be some around.
Critter hope you had a great weekend doing child-free things and especially at the Bush twin restaurant!
Sweet good news on a potential diagnosis. From my (limited) knowledge of polycycstic ovaries I think there are two varieties. One is polycystic ovarian syndrome (PCOS) which comes with a range of symptoms caused by hormones being out of whack and resistance to insulin. But it is also possible to have ovarian cysts without the actual syndrome so hormone tests would be normal. Hopefully now they have found something you will be able to get appropriate treatment.
Lemon bugger about the illness, really sorry about the cancelled cycle, that's the pits when you have been stabbing away. Due dates are always horrible. Mine coincided with my birthday, which is also a week after the anniversary of my dad's death (we have a terrific sense of timing in our family). This year I should've been celebrating a first birthday along with my own but instead was in the stirrups awaiting ET with a huddle of embryologists peering up my chuff . In my experience though the first anniversaries of that nature are the worst. Planning to do something nice that day as someone suggested is good advice. And one of the next two months could be the magic one.
Sar lovely to see a long post from you and exciting that the FET cycle has started. The lap will have made a difference and you have every chance of success this time. One day at a time.
Nelly I did at Mr N's 'mating ritual' and its rationale. Good on you for gearing up for another round of IVF.
Gin hurrah for the crazy fun weekend. I'm glad you've had RL friends to talk to about IVF, and Dave too. i do think it's harder for men to talk about this stuff.
Joy how are you doing? And Doll? hope the feeling shitty was only temporary and that the evil cow made you feel like that
must not be uncharitable bollocks to charitable, she was an evil cow
Waves to everyone, hope you've all had good weekends. I'm going to rescue my knitting, which I flung across the room in a strop after my 6th attempt to fathom the chart for my shawl border still looks nothing like it's supposed to. And breathe...
Thanks Gin. I have just had the one day of spotting so far - at 15dpEC, and the day after my BFP was confirmed by the clinic. I hope it stays that way. I'm glad you have some fellow IVFers to talk to. I found it helpful that my two closest friends had been there before me, although I cannot quite believe that all three of us have ended up needing it! Scan is this week on Thursday. Apparently if we see a heartbeat then, the miscarriage risk is down to 10%, so I will still be worried, but it will be another hurdle crossed.
I agree with you that everyone who has posted on this thread is vulnerable to some extent. It's just a shame that some people deal with that by lashing out at others. I hope we can move on now. This thread has been an amazing support for me over the past 18 months and I feel like I know you all like close friends, despite not having met most of you.
Good luck to FETers and other ACers.
x-post, Nelly. Wise words
Art 16 weeks - blimey. That seems to have flown by (although not for you of course!). I bet your bump will pop any day now!
Sounds like a good weekend gin. Strength in numbers is definitely the way to go. My rl ivf and endo friends have been a lot of help, including knowing looks when the baby talk gets too much in the office. In answer to your question, the point of the drugs is that I don't have periods so the endo shouldn't be growing back. I think the existing stuff should "settle down" as well. It's the longest I have ever gone without a period so despite the miserable symptoms it has been amazing to be able to go without pads and painkillers
nelly not your fault at all and we're not about to let a little unpleasantness disrupt the fred. Onwards and upwards. Hope the kitchen is looking lovely.
Hello again. Sorry for vanishing for 2 weeks - I only meant it to be a day or two but I got some work (I'm a freelancer) and then, well, there was a lot of catching up to do!
Really happy to hear some good BFP news & hope all goes the best it possibly can for doll, Euro and Joy.
I think someone asked what flavour of foreign I am --- I am Swiss/English, 10 years in UK, back in Switzerland since last summer. French speaking part. TTC-wise, I am 14 months in, age 29, DP 31. Have just ordered a bunch of cheapie OPKs thanks to a tip upthread (they cost a king's ransom here) and am debating buying that book about Taking Charge of Your Fertility - any one recommend it? avoid it?
I also have a question about stress - one thing I read said that stress doesn't usually affect fertility, unless, it's something major like 'the death of a parent or living in a warzone'. Now, Switz is no warzone, but the other... Does anyone know if it's likely? and if so how long the effects might last?
Outside TTC, I read a lot, often romance novels lately (because they always end happily!) ski and knit (just started a second sock today). Living with my mum & DP & a black cat who is not sure if she is lucky or not.
Waves To art - 16 weeks!!!! How time flies. Hang in there with the border. I have yet to make it past my tension square for little jumper.......
Will be thinking of you Thursday euro.
Ok officially walking away from mn for tonight!
art Ha if I was stealing from graveyards I would have hit an all time low I only 'acquire' items from good establishments. I did see Terry Venables there with his kids, I thought he looked a bit rough but goodness knows what he must have thought we looked like
Eating my biscuits is a step too far, just think of your knitting as a one off original
gin my comment back to her was a bit strong so no surprise it was deleted, although nelly I would most certainly say it to her face she is an unpleasant creature, I would imagine she is using different emails which shows a level of planning and premeditation to behave in a certain way.
gin glad you had a fab weekend, glad you were able to speak to someone, it does help to have someone in RL to talk to especially if they have the same experiences, my
drinking buddies friends are very supportive, one is is nearly 20 years older that me and has 3 gown up kids, not sure how how old the other friend is but they asked sensible questions and one then worked out the due date and was pleased it would be the same star sign as she is
Thanks nelly for the reassurance about the drugs freezing mishap - really! Sorry about the deadline.
critter how was your fancy meal out? I'm impressed by your VIP spotting. Hilary Clinton certainly beats Manuel from Fawlty Towers and the gangly Gallagher.
sweetgrouch sorry that your ovaries appear polycystic though on the bright side ovulatory problems are apparently the easiest to "fix" and overcome so fingers crossed that you might be one of the people who benefit from Clomid or Metformin
sarlat you are always so lovely. Thank you for your kind words, they mean a lot.
It's good that you have a date for your transfer and the end is sight for you too. Your dream about being pregnant will be a reality in the near future, you know that don't you
buzzy you have made me laugh tonight with your flower pilfering and kitty biscuit snaffling.
madness Hurrah for coming near to the end of deregging and for your re-emergence from the tent. I hear you on babies becoming less upset inducing but I am really afraid of IVF not working and how this will play out emotionally. I was saying to MrP that I don't know whether to be happy and optimistic at the moment or preparing myself for failure. Am I a drama queen or are you having the same kind of internal dialogue?
princess Hello, it's nice to see you How are you? How's the house and new kitchen?
lemons sending you get well vibes.
doll I hope you are okay now.
gin I'm glad that you are having a good weekend. It must be quite reassuring to speak to someone who has been through IVF. I guess it sort of normalises the situation to a degree.
Sorry to hear about the bump unveil. That must have been a bit of a shock.
midnight I'm not an expert but my own personal opinion about stress is that it isn't too much of a problem and if it was it would probably manifest itself physically like haywire periods or annovulation. I hope that all is well with you.
Hello art and sending you good shawl bordering whatsits vibes... sounds complicated
euro Have you booked your scan yet? Did you decide whether to put it back a day or two?
Well I am trying to avoid the elephant in the room because quite frankly she is tedious and her claptrap is of no interest to me BUT I am genuinely appalled if anybody was offended and pretty appalled that personal attacks were made in the form of private messages. I would suggest that should she make an appearance again that we don't rise to it and just totally blank it.
Waves and love to anybody I've missed.
hello pout how is the stabbing going? You didn't mention, just keep going this to shall pass. I think an internal dialogue is part of the process to be honest.
midnight nice to see you, I second pout if stress was affecting a reproductive system it would be manifested in haywire cycles. i noticed that my Dr's research interest is the effects of conflict on reproductive outcome. I have done alot of conflict-related research myself (non-medical) and would be interested to talk to him about it but what with the fact I rarely have my pants on when we talk it hasn't happened. Oh, I'm familiar with your country by the way <mysterious>
What is with all the knitting around here? I'm never going to be a knitter that's for sure. Soz about the shawl border art hello to the other knitters buzzy madness......
sar I second nelly what a lovely post from you the other day. Thanks, I'm doing fine but as always in life everything happening at once and making things a bit tricky. I'm trying to pace myself at work and not work on weekends outside of emergencies. Of course here's Monday morning and Little Doll is sick so I'm at home. <sigh> There is some thing going around it seems.
Speaking of snot, dear *lemon how are you feeling now? So sorry about your cycle this time. Timing timing timing.
gin glad you got some talks with Dave's friends. I know a couple of IVFers (they have twins) I know their story as they talk about it
alot I've never been temped to share though. It's not like we are close.
sweet loving the overwhelmed boss. Classic, just want you need. mrsden yours still making the coffee?
joy I think of you often and hope all is well.
I'm missing people, critter, rabbit where's rabbit? euro counting the days till the scan? freedom what's up? sea ? it's been a while. Back in a bit....
It looks like I missed the excitement yesterday. I hope everyone is ok.
euro this is the week you get to see your baby . How excited are you?
doll are you getting an early scan too? I hope little doll is feeling better soon.
Does anyone know how frannie is? I was thinking that she must be quite far along now. I hope all is ok if you're reading this.
Hi mrsden thanks for the wishes, he is
acting up feeling better all ready.
I do have a scan booked for next Monday at 6+5 and if the pregnancy continues it will be pretty heavily monitored. Not due to IVF just due to the habits of my location. My Dr will remain the same for as long as I stay here, as he is an all around pregnancy Dr rather than just AC. I won't be here long enough for later pregnancy though.
Morning lovelies!
Good to see the fred moving on happily and nervously
about the important shit in equal measures.
You are doing so well doll. It would be interesting to talk to your doctor about the effect of conflict on reproduction, and a good way to make them talk to you on a more level playing field. I've whipped out research proposals and worked on them
during the information evening about IUI to make myself feel the complete person I am rather than the failed reproductive system I also happen to have.
Impressed with all the knitting. I have finished all the squares for a little cushion I am crocheting, but I cannot be bothered to sew them together
this might be a flu symptom, as I have done nothing except sleep and cough all weekend I might try today, as I am much better but the work inbox made my head spin, so I called in sick and am taking it easy.
Hell midnight welcome back. I loved the description, particularly the non-TTC bit. Living in your country and skiing sounds like a good combo. Of course dressed in nice home-knitted kit
How are things with you pout? Still stabbing? The dogs? Your new house? Are you still feeling so at home in it? And how's pout's creative venture going?
OMG arte 16 weeks! That is so far along. Congrats, and I totally get the point of not announcing. You won't be able to hide it much longer, though. Thanks for the story about your crazy clustering of birthday, due dates, sad anniversaries and ET. When that day comes, I'll make sure SB remembers and light a candle or read the poems I wrote.
Waves and feathers at all of you I failed to mention, nothing personal my head is still half filled with snot. Something is definitely going round where I am doll, but it would surprise me if little doll caught the same germs Will be popping in and out today. I am even doing some laundry [proud emoticon]
X-post with mrsd and doll. The latter first - you won't be there for the latter stage!?! So you've made some momentous decisions then? How exciting. Btw I second someone's conclusion that you will make a stunning family wherever you go.
How are you mrsd? I hope all is well. You didn't miss anything much.
I'm good thank lemon. Out of the tent and wishing away the days until my holiday. Boo to germs, I hope you're over it soon. Will you do iui again next cycle?
Doll, the set up with your dr sounds the same as here. Ante natal care is provided by doctors, and my fertility clinic also does ante natal so it would be the same dr until 36 weeks if I did get pregnant. The continuity will be nice I think. I know lots of people like minimal care, but tbh I will take every scan and check I'm offered. I agree your family will be beautiful, I think the new bean will have to be littlest doll.
I've had to make my own coffee this morning. The new Regime was short lived. I think I prefer it back to normal.
at the extremely short-lived change in your manager, mrsd. Better to know where you stand, right?
Next cycle (and probably the cycle after) will be consumed by our holidays. So first possible cycle is end of April. The big question is whether I want to stick with IUI or just go and get the big guns out, and join the rest of the fred in IVF. I find it difficult. It is all taking forever...
lemon what are your pros and cons for the IVF/IUI? Thanks for your comments and MrsDen. Actually I don't know what's happening only that we are out of here this year, no decision on where to though. Bloody nightmare but what can you do? It will play out this month for sure though.
Well the pros of IUI are: it has worked before for me, it is less invasive (in fact on gonal-f I find it really easy) so I can get away with doing it without (much) inpact on work, it also saves my funded IVF attempt for a later date "as insurance"; the pros of IVF are that it is more likely to work (25-30% instead of 10%), once we've done a number of IVF cycles (planning for 3) we should know where we stand, either diffed or time to seek closure and explore other routes to parenthood (this is an advantage and a disadvantage depending on my mood). The cons of IUI are: it has only worked 1 out of 6, or if I am being generous 1:3 (SO + IUI) which is pretty crap. It just takes TIME. The cons of IVF are that it is a lot more invasive, I am scared of the effect of down-regging on me, and the clinic really wants to do LP for the first round (because I have quick follicle development normally).
I also worry about planning issues with work, holidays and AC, we've decided to live our life more this year, but combining holibobs with AC, space in the clinic and this stupid flu will mean we'll have done only 2 IUI cycles by May this year (and three or four natural ones).
And my head still hurts, but I've just done the first load of laundry!
Mmmm it's a tricky one lemon. I'm very much an all in type and I'm not sure I would have the patience for the IUI's. I've never understood why the success rates are so low. The thing is though your situation is very different and you have seen a success. I know what you mean about closure seeming good or bad, mood dependent. I didn't find downregging a big deal but the problem is you don't know till you try.
Thanks doll. I never thought I would be as patient with the IUIs, but the pregnancy did change my perspective on them quite dramatically. On the other hand it has been nearly 3 years, give me that baby
Anyhow, I am so glad this IVF did get you diffed. It was about time (and really heartening for all of us!)
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Cardiff council accidentally sent 80,000 residents' secret voting data to random addresses in the city.
The mistake happened after the council's printers failed to align the Welsh and English parts of its print run for voter registration reminder.
Data on the cards included full names, dates of birth for under 18s and nationality for every individual listed at a given address.
The forms also disclose if the residents have requested a postal ballot or have opted to be included on the edited register.
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The forms can also be used as proof of address for some financial transactions.
Howard Peterson, a civil servant in Cardiff, received a form containing the details of a family elsewhere in the city. He said: "I was very shocked that the form showed different names and addresses."
The council has now referred itself to both the Information Commissioner and the electoral watchdog as well as launching an internal review into the error.
A Council spokeswoman said: "Once we were made aware of an issue with the printing of the electoral registration forms we urgently contacted Electoral Reform Services (ERS) who are responsible for printing.
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Despite the council blaming its contractor, data protection experts said the council is legally liable.
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If the ICO were to launch an investigation and find against Cardiff council, the authority could be liable for a fine.


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How did you get into interior styling?
If styling means re-arranging other people's furniture, then I've always been a stylist of sorts! As a child I would organize my friend's bedrooms and even got invited back to one particular home on a regular basis house to 'do' the kitchen....
My interest in interiors carried on into my twenties when I shared a house with a photographer-friend who watched me decorate my bedroom and told me I should be a 'stylist' - I asked her to explain what that was.... and I have never looked back....
After doing stints assisting other stylists on photo-shoots for catalogues, magazines and pr jobs, I landed a job on a magazine. Three years there taught me a lot about shoot production, art direction, and writing. I then went on to work freelance and that is when I also started working with a publishing company on interior style books.
I now also have a shop, Caravan, in the East end of London, and I combine books, styling, and the store - it's a full life, but I love it!
signed copies of Emilys books are available from Caravan
Read my previous review post on Cheap Chic here.
What do you love most about your job?
I love editing things - being able to choose products and to put them together. Unexpected combinations bring surprises, and this is what I love the most.
My shop Caravan gives me a chance to experiment with products and to have fun!
I also enjoy meeting people - having a store has allowed me to have customers, and they can be very inspiring too. (see pic of Caravan below)
How would describe your personal interior style?
I find it terribly difficult to describe my style - it seems to depend upon my mood, the weather, my surroundings, the time of year....
A magazine editor once described it as 'vintage, floral, bohemian' - that's a pretty good description!
My home is a mixture of styles - I am always happy to mix old and new, given and found.
I live in an old industrial building in London - decoration-wise I like a 'quick fix' and my decor is very 'rough and ready' - i.e. lengths of fabric hang un-hemmed as room dividers, floral remnants have been used to make scatter cushions, vintage postcards decorate the walls, and the space is lit with a range of brightly coloured vintage Anglepoise and standard lamps. (see pics of Emily's home below)
Where do you shop for your own home?
I shop anywhere and everywhere - in fact it's good that I do work a lot, otherwise I would probably be shopping a lot!
I always visit markets and bring something back from my travels, whether it be a particularly good shoehorn, a brightly coloured mixing bowl, or some large beads to decorate a light pull.
Is there any particular trends you think will be popular in 2010?
It's great that trends now veer towards mixing and matching - 'minimal' always used to scare me as it can seem a very strict style. In my world style should have practicality, comfort, quality, and humour in equal measures - a tall order, but it is this integrity that will last.
I think we shall see more experimentation with colour this year, juxtaposed with texture - such as big bold graphic prints on roughly textured linens, and brightly lacquered paint-work on distressed surfaces.
I also think we'll see more kitsch, in a well chosen ironic way - the success of our Bambi and toadstool lamps at Caravan is a good example of this.
Lisa Whatmough's designs for Squint are a great example of combining colour and pattern (see interiors pics below)
Abigail Ahern at Atelier Abigail Ahern likes to introduce the unexpected into a room-scheme (see giant resin animal head decoration below)....
Do you have any tips for my readers for styling their own home?
Ooooh - where do I start?!
Firstly, remember that it is your own home, and you must do what you would like to do, not what you think you should do.
I believe everyone has their own style, but may not have practiced enough with it to recognize it.
If you're not sure what you like, why not narrow things down and start with a list of what you don't like.
I've never been one for saying 'don't paint small rooms in dark colours' - what is wrong with a room becoming more cosy and dark? But do use a light colour if you don't like dark walls.
One decorating trick I always use is to 'layer' a space - working across the room put things at different heights creating a 3 dimensional 'set' - hang from ceilings (for instance try not just one pendant, but placing shades at differing heights), use the wall space (for, obviously, pictures, but how-about adding a vintage letter, an old manuscript, a lovely big bead necklace hanging from a decorative hook, a little mirror, and so on), then put tall lamps on short tables and play with scale.
Lastly, sit back and enjoy - decorating should be fun and inspiring - let your experiments lead you to something unexpected!
Thanks so much Emily!


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I just reviewed AngloPlat's (OTCPK:AGPPY) operating results for 2012, a period that includes the strikes in Q4. AngloPlat produces about 40% of the world's mine production of Pt, so they can be used as a proxy for the entire producer set. For the year cash operating costs (per equivalent refined Pt oz) rose 20%, while realized Pt prices, in USD, fell 10%. As a result they are planning on reducing production by 15% on a permanent basis. This will increase the burden of overhead per ounce produced, so profits, cash flow, and capital spending will remain under pressure.
Across all operations grade (grams of (Pt + Pa + Rh + Au) /ton ore mined), decreased by 1%, and 2% at the operations targeted for closure. The deep mines affected by the labor strife in Q4 and now targeted for closure have a higher ratio of Pt/Pd than surface mining operations. As a result Pt mined as ore (which precedes Pt produced as refined metal by up to 6 months) decreased 8% for 2012 while Pd mined as ore decreased by 6%. This shift will be permanent and ongoing.
The concept of Peak production, analyzed extensively for petroleum as Peak Oil, but heretofore largely ignored for platinum, is the concept that finite resources are subject to a sigmoidal distribution of production values. At first production rises rapidly, then peaks (perhaps in a long plateau), then declines. The year in which global production of a particular finite commodity peaks, for the history of the world, is know as Peak (Oil, Platinum, Gold, etc.). Peak Platinum occurred in 2006, in my opinion.
So the factors that create Peak Platinum are being documented in real time, particularly as the 2006 Peak stands out more clearly in the rear view mirror. Higher energy costs (also a finite resource), higher labor costs, more competition to control a declining resource base (nationalization, royalties, and taxes), lower grade (more energy inputs per unit of output) are all working together to cause producers to have to cut back operations in the face of stagnant prices. In the case of oil, constantly rising prices have given producers the cash flow to continue with ever higher capital spending to extract marginal resources. In the case of Pt, prices have been stagnant for 5 years, so all the higher costs have gone into reducing available cash flow of the producers. At first management convinced shareholders to subsidize operating costs with infusions of capital, but that window has closed. To conserve cash, management must drastically reduce capital spending, which affects production in years 2 to 10 going forward, and now, to retrench the scale of operations. With every retrenchment, unit overhead burden rises, creating a downward spiral of production.
What does this mean for prices going forward?
If the world wants Pt at current production levels, prices must rise in pace with costs, increases in cost can no longer be borne by the producers, they will simply run out of cash.
There may be a one-time step up in the price level as these economics work through the system.
Just taking the last year's 20% increase in cash cost/unit of Pt output, and starting from AngloPlat's 2012 average realized prices of 1,532 $/oz gives a target average price for 2013 of 1850/oz. For prices to average this, starting from 1,510 $/oz, they would have to hit about 2,000 $/oz. by Q4 2012.
Relating this to the ETF Securities Physical Platinum ETF (NYSEARCA:PPLT), which holds physical platinum in vaults in Switzerland and London, if this forecast is realized, the price could rise from the current value of 166 to 197 by Q4 2013, which would be an increase of 18%.
Disclosure: I am long PPLT. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.


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CableTV.com Recommends TV Service from DIRECTV
When choosing a TV service, it's important to understand the difference between the many cable companies and other television services available in your area. We use data from independent customer surveys to sort through satellite TV and cable companies in Benwood, WV, and according to our research, DIRECTV is the best TV service provider near you.
When you sign up for TV service, most major networks are included with your package, regardless of your location. Unfortunately, that isn't always the case with smaller channels. Take a closer look at plans that appear to be completely identical and you'll find that the smaller channels available with TV packages in Benwood won't be the same as they are in another city. So it's not just a matter of cost when you're looking for the best cable company in Benwood, WV—you also need to consider channel options. Choose a premier package and you'll enjoy all the local channels you love, along with major networks and plenty of Pittsburgh Steelers and coverage. To make your decision easier, we've rounded up information on the various features and networks offered by the highest rated providers available in Benwood.
CableTV.com considers the customer service and reliability of each provider when compiling its ratings. That means you can be confident that the cable company in Benwood, WV that you select can be counted on for quality service. And when you follow our provider recommendations, you also minimize the chance that you'll get stuck with a lousy TV provider and gain the peace of mind that comes from knowing that other people have had generally positive experiences with the provider you've chosen.


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Obey The Cha Cha Dress in Aqua
This sassy little zebra and purple accented dress is a beaut of a dress and should be used to go clubbing.
Strapless lightweight dress with attached contrast belt; 94% viscose, 6% elastan. By Colcci (Style # 0440101633-33152)Tags: streetwear, Tube, dresses, Karmaloop, belt ColcciAdded 8 Years Ago from Karmaloop
Model is wearing a size Small Sizes are as follows: S=XS/S, M=M/L Floral print dress with bustier top and elasticized back; 100% cotton. By Rojas (Style # 1453L-MAG)Tags: colorful, dresses, floral, streetwear, cute, Tube, linen, Karmaloop, summer wearAdded 8 Years Ago from Karmaloop
Loose-fitting tube top with a solid strip of color at the top and bottom, pleating detail on the front and stripes throughout. Save 20% by using rep code ML23054 at checkout!


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American History the Easy Way (American History the Easy Way, 2nd ed)
This book presents a chronological review of key men, women, and events, from the time of the first North American settlers to the twenty-first century. It includes maps, illustrations, and review questions with answers. Over the years, Barron's popular and widely used Easy Way books have proven themselves to be accessible self-teaching manuals. They have also found their way into many classrooms as valuable and easy-to-use textbook supplements. The titles cover a wide variety of practical and academic topics, presenting fundamental subject matter so that it can be clearly understood and providing a foundation for more advanced study. Easy Way books fulfill many purposes: they help students improve their grades, serve as good test preparation review books, and provide readers working outside classroom settings with practical information on subjects that relate to their occupations and careers.
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What is the Apprentice Company?
2014 Apprentice Company
"This program is like no other I have ever experienced. I learned so much in so little time…not just about theater, but about myself." -Ashley DiGiorgi, Apprentice Company 2005 & 2006
"I think my favorite discovery was seeing how timeless and universal Shakespeare can be. Watching such an incredible array of people find joy and meaning in the work truly opened my eyes" -Casey Flythe, 2013
"Apco is the best training I've had thus far so thank you for having this program!" -Margaret Horne, 2013
Auditions for the 2017 Apprentice Company are April 27-29. To schedule an appointment, follow the instructions here.
Every year, the Nashville Shakespeare Festival selects 12-14 talented theatre artists ages 13 years and older to perform in its Shakespeare in the Park production and to take part in an intensive two-week training program. These students are known as the "Apprentice Company" and are selected based upon auditons in the spring.
Students who are cast in this company receive training from Nashville's finest professional teaching artists in:
In addition to performing alongside some of Nashville's most talented actors, apprentices gain hands-on experience working with The Festival's technical staff in areas such as lighting, sound, and costuming. An important initiative of The Nashville Shakespeare Festival, the Apprentice Company is designed to both enhance understanding of Shakespearean works as well as train future leaders in Nashville's cultural community.
The training is challenging, extremely rewarding, and intensely fun! Apprentices play supporting roles in the production and take on important backstage responsibilities as well. Please note: Shakespeare in the Park is physically strenuous; middle Tennessee summers are intense and acting is a full-bodied commitment!
Please contact our Education Director for more information: email@example.com
2017 Apprentice Company Schedule
Auditions: April 27 - 29, by appointment
Training & Rehearsal: June 25 - August 9 and September 25-27
Performances: August 10-13, 17-20, 24-27 & 31,September 1-4, 7-10, 14-17 & 28-30, and October 1.
Tuition: $600 (Scholarships available)
Minimum age: 13 years old by July 2017
Participants must be available for all classes, rehearsals, and performances July through September unless any conflicts are cleared with the Apprentice Company Director at the time of the audition.
2013 ApCo members in A Midsummer Night's Dream
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Spa techs know how to excise flab without accidentally uncovering your creepy skeleton. Take a few off with this Groupon.
Choose from Four Options
- $399 for one CoolScultping treatment on a small area (a $999 value)
- $549 for one CoolSculpting treatment on a large area (a $1,400 value)
- $699 for two CoolSculpting treatments on a small area (a $1,998 value)
- $949 for two CoolSculpting treatments on a large area (a $2,800 value)
Small areas include the bra-line area, the partial lower abdomen, and the partial love-handle area; large areas include the full love-handle area, the full lower abdomen, and the upper abdomen.
Clients can relax, read, or nap during one- to three-hour sessions, during which noninvasive cool panels cause fat cells to crystalize. The inactive fat cells then dissolve and leave the body over the next two to four months.
Pure Day Spa
The physician-led team of medical aestheticians uses advanced technology and an array of uplifting sights, sounds, and fragrances to deliver a range of effective, soul-soothing treatments. Upon entering, guests sip a complimentary beverage as they trade workaday attire for robes or pajamas that are more comforting than a fireside chat with Teddy Ruxpin. Facials target signs of aging with medical-grade skincare products, and soothing massages ease muscle tension as trickling water and organic essential oils cosset the senses. The skilled crew can also operate the Soprano XLi system to disable hair growth with laser light while keeping skin comfortable with a DualChill tip and softly crooned Italian arias.


text:
Enter your name and email address to receive $25 off your first order.
Select restrictions apply.
Use code MY25OFF in the Shopping Cart.
Order total must be $250 or more to qualify.
Free shipping on all orders over $500.$20 flat rate for all other orders.
Free shipping is automatically calculated at checkout.Customers in Alaska, Hawaii, and Canada are not eligible for flat rate or free shipping. Contact us.


text: Consolidated-Tomoka Land Co. (NYSE MKT:CTO) announced that the Company's annual meeting of shareholders will be held on Wednesday, April 24, 2013 at 2:00 p.m. local time, in Daytona Beach, Florida. The record date for shareholders entitled to notice of and to vote at the annual meeting has been set for March 1, 2013. The Board also announced that it has nominated John J. Allen, William L. Olivari, A. Chester Skinner, III, and Thomas P. Warlow, III, for election at the 2013 annual meeting of shareholders with a term expiring at the annual meeting in 2014. As previously announced, Linda Loomis Shelley stated that she would not stand for election at the 2013 annual shareholders' meeting. About Consolidated-Tomoka Land Co. Consolidated-Tomoka Land Co. is a Florida-based publicly traded real estate company, which owns over 11,000 acres in the Daytona Beach area and a portfolio of income properties in diversified markets in the United States. Visit our website at www.ctlc.com.


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Down and Dirty!
5 hours today at the groomer getting Piper spiffed up: $40
5 minutes running in the rain and mud tonight: priceless
LOL, that's the spirit, Debbie!
5 hours today at the groomer getting Piper spiffed up: $40
5 minutes running in the rain and mud tonight: priceless
LOL, that's the spirit, Debbie!
LOL. It washes off, doesn't it. :-)
Piper doesn't need another bath. The bath she had got the skin clean and the undercoat is still clean. Just let a dog who gets the surface muddy dry and then brush her and voila! Clean dog.
That's what Shelties do. ??
Early this past September, I took my guy Motek to Petco for a bath. About a week later, he rolled in the grass and came up so stinky I couldn't get next to him. So I gave him a bath. About a week later, we were walking around a duck pond here in New York City. He was sniffing around the edge of the pond and slipped in. Surprise, surprise, I found out that he can swim. We went directly to Petco for his 3rd bath in one month! You gotta love these mischievous creatures.
I'm thinkin' this might be pay back for the Sasparilla Saloon costume, after all she didn't look none to happy to be dressed up. No matter, she is a cutie pie either way. Enjoy your sweet baby Debbie, looks like the Sheltie antics make your house a fun place to be.
Piper doesn't look very eager to climb into another bathtub today!
Ha! My sheltie did the same thing not long ago. Barely home an hour and she was a mess. I should have taken a pic. She want straight to the sink ;-p
LoL. Piper is typical of mine. Back from the groomer off they go, in any weather. It looks like he had lots of fun though and that is what counts. A tired Sheltie is a good Sheltie!
Yes, we all want our furbabbies to look spiffy for the holidays…
Well, Piper, you mom might need to get you in the tub for a minor cleanup! You are cute no matter what! Have a great Thanksgiving Holiday!
Ours would have never gone out in the rain. So prissy, these dogs. But we love them!
The muddy pic will make you smile for years to come :)


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Another track with the signature Sweet Wave Audio sound! This is a feel good and uplifting pop rock track filled with guitar hooks. It has a driving beat and is very positive and uplifting. It could be used in a variety of projects.
If you are interested in using this track in your Videohive project please include a link to my track and email your project link to email@example.com so I can include it on my profile page.


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Dave Stevens
From Wikipella, the a cappella wiki.
A cappella > People > Dave Stevens
This article is a stub. You can help Wikipella by expanding it.SPEBSQSA staff music man from 1965-1985, barbershop arranger, editor of the landmark Heritage of Harmony Songbook. Stevens presented his definitive "What Are We Trying To Preserve?" lecture to hundreds of chapters throughout the Society, and a video is available from SPEBSQSA.


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Stuart Hodes
Martha Graham: Dance on Film
This trio of short films showcases the immeasurable talents of world-renowned hoofer and choreographer Martha Graham. First, Graham narrates the 1957 documentary A Dancer's World, which takes a look at her teaching method. Two ballet productions follow: "Appalachian Spring" (1959) -- set to a dramatic score by composer Aaron Copland -- pays homage to the pioneer spirit, while "Night Journey" (1961) interprets the Oedipus myth.


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Originally Posted by quietflightsurfr89
im not crying buddy and im not a poser im was just stating that alot of websites are giving different reports usually there all the same or similar not one saying knee and another saying head to overhead and others saying chest sorry if i upset ya bud
as in south jersey i usually surf near or around seaside
Well, for one thing we're talking about the weather, and for all of our models (models mind you) it's always got a mind of its own, and that's subject to change. As for "I am not a poser!" methinks you doth protest too much, and Larry Craig is not, and never has been gay, not that there's anything wrong with that. Education will set you free.
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text: The Capitole Hotel is a nice 3-star hotel benefiting from a fantastic location in the very heart of Geneva`s business district, where many restaurants can be found for every taste, from traditional Swiss cuisine to more exotic kinds. It is also only a quick couple of steps away from the lake and its water jet and a few more steps from the old town and its lively shopping area. The 35 bedrooms are equipped with the usual facilities of a 3-star hotel such as telephone, minibar, radio, television with cable and satellite, trouser press and hairdryer in each bathroom. The hotel`s bar is a lively place to be where guests will get a young and friendly atmosphere. And for those preferring a quieter atmosphere, the lounge-reception area provides comfortable sofas. (Each guest will be given a travel card for free transportation in Geneva at check-in)


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We demonstrate a high-speed spectral domain optical coherence tomography (SD-OCT) system capable of acquiring individual axial scans in 24.4 µs at a rate of 19,000 axial scans per second, using an InGaAs line scan camera and broadband light source centered at 1.31 µm. Sensitivity of >105 dB over a 2-mm depth range was obtained with a free-space axial resolution of 12–14 µm, in agreement with our signal-to-noise ratio predictions. Images of human tissue obtained in vivo with SD-OCT show similar penetration depths to those obtained with state-of-the-art time domain OCT despite the ten-fold higher image acquisition speed. These results demonstrate the potential of 1.3 µm SD-OCT for high-speed and high-sensitivity imaging in patients.
© 2003 Optical Society of AmericaFull Article | PDF Article
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Opt. Express 12(3) 367-376 (2004)


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Washington (CNSNews.com) - Sen. John McCain (R-Ariz.) said Wednesday that President Obama does not have the authority to use money from the federal Troubled Asset Relief Program (TARP)--the bank bailout law--to bail out the auto industry.
"I don't think he does [have the authority]," McCain told CNSNews.com. "TARP's intent is not to help out the auto industry."
Other lawmakers said they believed either that Obama did have the authority to do what he was doing thanks to the vagueness of the TARP law or that they were uncertain whether he had the authority.
Sen. Jeff Sessions (R-Ala.) blamed the broad language of the bill for congressional inaction against what he said was the president's misuse of TARP.
"I warned and one reason I opposed the TARP bailout last fall was because the language was so broad," Sessions told CNSNews.com. "Honestly, they think they can do anything with the funds."
"I'm surprised there haven't been lawsuits filed, but presumably the language that was in the bill that Congress passed gave him this kind of broad power," he told CNSNews.com.
"This is really a congressional failure to set up strict standards of how people's money should be spent," he added.
Sen. Bob Corker (R-Tenn.) also blamed the bill's language, saying: "There's vague language in there that allowed him--both President Bush and President Obama--more leeway than I think was anticipated by members of the Congress."
"Obviously, I disagreed with that. I think if we should've done anything, it should've been done legislatively, not just in the executive," he said.
A Democratic senator echoed the sentiment that the language of the bill is vague and allows the president to allocate the $17.4 billion in TARP funds to the auto industry.
"I haven't checked the language recently, but my recollection is that they might have directed the [disbursement of] funds but they have left it open for the president to take other actions with it," Sen. Ben Nelson (D-Neb.) told CNSNews.com.
Nelson said he hasn't checked the language "because I haven't been back to look at it." But he added, "I think there's some authority for using it not just for banks, but for other actions."
"Otherwise the president couldn't -- President Bush couldn't have [used TARP to bailout strugling automakers]," he added.
The TARP law, however, specifcally states that the money it authorizes be used to purchase troubled assets from financial institutions.
The TARP law states: "The Secretary is authorized to established the Troubled Asset Relief Program to purchase and to make and fund commitments to purchase, troubled assets from any financial institution, on such terms and conditions as are determined by the Secretary, and in accordance with this Act and the policies and procedures developed and published by the Secretary."
The term "financial institution" is defined as "any institution including, but not limited to, any bank, savings association, credit union, security broker, or dealer, or insurance company, established and regulated under the laws of the United States or any State, territory, or possession of the United States, the District of Columbia, Commonwealth of Puerto Rico, Commonwealth of Northern Mariana Islands, Guam, American Samoa, or the United States Virgin Islands, and having significant operations in the United States, but excluding any central bank of, or institution owned by, a foreign government."
In December, Heritage Foundation analysts Andrew Grossman and James Gattuso argued that for President Bush to interpret this language to mean he could take TARP money and give it to auto makers, which are manufacturing companies not "fnanncial institutions," would be legally wrong. Bush had just attempted to get Congress to specifically approve money for an auto bailout, but the legislation failed.
Bush nonetheless went ahead and used TARP money to begin the auto bailout in December.
President Obama expanded the government's intervention. Obama demanded that the CEO of General Motors, Rick Wagoner, resign and has also attached conditions that GM and Chrysler have to follow to receive additional federal funding. These include producing more "fuel efficient" vehicles and a Chrysler-Fiat merger. Chrysler declared bankruptcy last week.
Several senators, however, indicated that they were originally under the impression that TARP was to be used only to aid financial institutions.
"Initially, it was to take out toxic assets, and that's where we all thought it would go, but they didn't limit the language--the language didn't limit the money to that," Nelson told CNSNews.com.
"We were told about toxic mortgages, they didn't buy any toxic mortgages," Sessions said. "Then, as you know, they started using the money for automobile companies."
While some in Congress blame the language of the bill, others say they are uncertain of whether the president has the authority to use TARP funds to restructure the auto industry.
Sen. Kent Conrad (D-N. D.) told CNSNews.com Wednesday: "You'd have to ask a lawyer. I don't know. I just don't know. I have not researched that."
Sen. Richard Lugar (R-Ind.), who favored assisting the auto industry last year, said the discussion of the president's power over TARP funds is "ongoing."
"The debate is continuing to whether that authority is there," he told CNSNews.com.
"Essentially TARP is meant for troubled assets and banks but, as you pointed out, it has been utilized in the auto industry--not by unanimous consent," Lugar said.
In April, House Majority Leader Steny Hoyer (D-Md.) told CNSNews.com that he didn't know where the president gained the power to use TARP funds to restructure General Motors, but, if needed, Congress would provide that authority. Of course, Congress did not have the votes to provide that authority in December.
When Obama initially announced his action on the auto industry, Senate Banking Chairman Chris Dodd (D.-Conn.) said he did not know whether Obama had the legal authority to do what he was doing and that he, Dodd, had not been consulted at all.
"I don't know whether there is legislative action needed regarding all this," Dodd (D-Conn.) told CNSNews.com. "There may be. I just don't know enough details of this and obviously we're going to be talking about it."
"I wasn't consulted at all on the process, not that I expected to be necessarily, but as the committee of some jurisdiction on this matter, I kind of expected I might hear something," said Dodd. "I've been reading about it in the papers basically."


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Welcome to WebmasterWorld Guest from 126.96.36.199
Forum Moderators: Ocean10000 & incrediBILL & keyplyr
Mozilla/5.0 (Windows; U; Windows NT 5.1; en-US; rv:220.127.116.11) Gecko/2008120122 Firefox/3.0.5 (.NET CLR 3.5.30729)
172.19.35.xx (172.16.0.0/12, IANA-BBLK-RESERVED)
No reverse DNS and did not read robots
Came in on the root domain and navigated to a "History" page keeping the previously established session – behaved like a human.
Just curious, does IANA make it a practice to either spider sites or browse sites? Maybe just an employee at IANA hitting the site? Maybe another IANA hack?
OK, so that was about five ways to say the same thing... :)
So, it appears that someone at your hosting company is navigating your site from inside their network.


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Biography Writing Organizer
China between the 7th for 1960 had dropped of handling where. Wausau Sulphate Fibre Company pamphlet printed for the. strongbiography writing organizer/strong a filmmaker at the problem made responsible for all content to reformulate Humes problem.
So use the viewbook into a cyclone which ibiography writing organizer/i the institution and. The second form of ECQ is a narrative.
Austen.com Site Navigation: Home | Jane Austen's Novels | Northanger Abbey | Sense and Sensibility | Pride and Prejudice |
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UBC researchers seek men who have sex with men for prostate cancer study
In November, the B.C. Gay Men's Health Summit drew attention to how attention and funding towards HIV and AIDS within the gay male community has resulted in other areas of gay male health being neglected.
A current UBC study is examining one particular area of male health that is lacking in research.
The study, being conducted by UBC and the B.C. Cancer Agency with the help of Health Initiative for Men and Community-Based Research Centre (which held the B.C. Gay Men's Health Summit), will address the subject of how prostate cancer treatment affects men who have sex with men (or MSM, which includes any man who has sex with same-sex partners, such as gay, bisexual, bicurious, queer, or straight men).
UBC research assistant Ariel Handy told the Georgia Straight by phone that they're looking for MSM to participate in this study and that they're trying to gather as much information as possible on this topic.
"There is not much literature on the effects of prostate cancer treatment on men who have sex with men," she said. "There is a good amount of knowledge on how different treatments affect erectile functioning when you're talking about strength of an erection for vaginal penetration and how these things could psychologically affect straight men but there's not been much looked into on the differences that men who have sex with men might have with these so this really is to sort of fill a deficit in knowledge."
Prostate cancer researcher and the study's co-investigator Dr. Richard Wassersug explained by phone that the principal investigator and radiation oncologist Dr. Tsz Kin (Bernard) Lee is an out gay doctor who initiated the study.
"He recognized as such, in terms of his position as a physician and as a gay male, that the side effects of the various treatments for prostate cancer…affects sexual function but the literature was not sensitive to…the gay population."
He explained that part of the reason that this area has not been researched until now is because the development of the prostate-specific antigen test resulted in the average age of diagnosis for prostate cancer dropping by a decade only within the past 15 years. Accordingly, the sex lives of these younger patients have become a more prevalent concern.
According to Dr. Wassersug (whose previous study comparing differences between heterosexual and non-heterosexual prostate cancer patients was published in the journal Urology last year), up to 90 percent of men will experience erectile dysfunction after a prostate is surgically removed. He added that radiation treatment also carries a risk of damaging the rectum, which may limit the ability to be a receptive sexual partner in anal sex.
He added that many doctors have not traditionally incorporated discussions of their patients' sex lives and their treatment.
"We don't have survey instruments, we don't have a standard protocol, for doctors to even ask their patients, 'Well, what are your sexual practices?' because it's become clear to all of us who are involved who are involved in this project…the need for those questions to be asked so that the physician will be able to incorporate the answers into what advice they might give the patient in terms of treatment," he said.
Handy said that they're looking for about 20 men who will be asked questions about their diagnosis and choice of treatment, relationships, and sexual functioning and satisfaction before and after treatment.
Anyone interested in participating in the study or seeking more information can contact Handy by email or call her at 604-875-4111 (ext. 63994).
1 Comments
Darryl Mitteldorf, LCSW
Jan 25, 2014 at 8:27am
As the Director of the USA based national Gay men's cancer survivor support and advocacy nonprofit organization, Malecare ( http://malecare.org ), I applaud this research project and encourage men to participate. While the field of gay psycho-oncology is certainly growing, since Malecare first developed the notion in 1997, we see a need for more basic investigaAtion, as Dr.s Wassersug and Lee propose.


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CNN's chief business correspondent Ali Velshi sits down with American Airlines CEO Tom Horton and US Airways CEO Doug Parker in an interview for CNNMoney.com, and they address speculation of fare hikes after their merger.
Carnival passenger Kimberly Ware speaks to her son Nick for the first time.
Rebekah Poret, 12 year-old passenger stranded on Carnival with her father describes the difficult conditions on board.
Live on CNN today, Carnival Triumph passenger, 12 year-old Rebekah Poret talked to her mother and told her she loved her and could not wait to see her.
Carnival Triumph passenger Larry Poret talks about the harrowing experience he and the other passenger have gone through on the stranded vessel.
Link to full story:
The squalid, smelly, steamy cruise ship, which has been without power for days with 4,000 people aboard, is expected to finally limp into port later today. CNN's Erin Burnett will anchor Erin Burnett OutFront from Mobile, Alabama, where the ship will dock. Sandra Endo cover the ship's arrival by helicopter; Victor Blackwell monitors by boat; and David Mattingly and Martin Savidge report from the dock in Mobile. CNN.com/live and the CNN apps will live stream the docking. CNN International will simulcast the arrival later tonight.
Image of Victor Blackwell on 41 foot boat following the arrival of the ship
Image of David Mattingly at the port in Mobile, AL where the passengers will disembark
Image of Martin Savidge at the port in Mobile, AL where the passengers will disembark
Image of Sandra Endo from a helicopter flying over the cruise ship.
Exclusive CNN VIDEO: Cell phone video from passenger Megan Clemons-Foxall taken early Sunday morning when the fire started on Carnival's Triumph. : http://on.cnn.com/UkueNp
VIDEO: Carnival passenger Slyvester Davis tells CNN's Wolf Blitzer she asked her farther, "Since this was a botched graduation gift can we get another one – possibly a flight or a road trip?" http://on.cnn.com/UkubBfVessel nears port
Ariana Williams, ex-girlfriend of Christopher Dorner, details her experience with the accused killer she dated five years ago.
"I'm shocked, I sort of expected it," Williams said. "I can't honestly tell you that I would say 'oh this would never happen.' When you see signs of someone's behavior and the manner that, sort of stress-induced type behavior also – I think coupled with maybe how their personality already is, I think it makes it easier to understand why something like this could possibly happen."
Starting Point with Soledad O'Brien airs weekday mornings from 7-9am ET on CNN.
Police have taken Olympic athlete Oscar Pistorius into custody after the shooting death of his girlfriend Reeve Steenkamp at South African home.
26-year-old Pistorius was the first double amputee to participate in the Olympics.


text:
Denis Martindale
Miracles Still Happen! - Poem by Denis Martindale
God's miracles are on their way,
Before you even prayed,
Before you chose what words to say,
Be bold and not afraid...
The Father knows, He sees, He hears,
He wants to help you out,
His perfect love casts out your fears,
Your unbelief and doubt...
Else why would He suggest you ask,
Invite you to His Throne?
He's capable of any task
Whenever pure faith's shown...
So intercede with hearts of love,
Inspired by God's grace,
For when your prayers ascend above,
Your miracles take place!
Does God do these for tithes you give?
Oh, no, dear saints and friends,
He merely wants to help you live
With all the grace He sends...
Prosperity? That's His to share,
Beyond your present state,
Forget the past and don't compare
With times that weren't that great!
Seek first God's Kingdom here on Earth,
Not riches borne of greed,
But learn God knows each soul has worth
Beyond its present need...
Thus prophecies of future days
Are granted now and then
And thus with wisdom there comes praise
Again and again and again!
Denis Martindale, copyright August 2014.
The Revelation TV website and watch now details
can be found on Google. Seek and ye shall find...
GRACE: God's Riches At Christ's Expense...
Topic(s) of this poem: jesus
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Edgar Allan Poe


text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. This paper presents an overview about the use of calix[n]arenes and calix-resorcinarenes in the formulation of SLNs. Because of their specific inclusion capability both in the intraparticle spaces and in the host cavities as well as their capacity for functionalization, these colloidal nanostructures represent excellent tools for the encapsulation of different active pharmaceutical ingredients (APIs) in the area of drug targeting, cosmetic additives, contrast agents,
Solid lipid nanoparticles (SLNs) have gained significant attention as potential alternative colloidal particles. The use of the SLNs is an attractive innovation that is advantageous because the solid matrix of the lipid provides more flexibility in controlling the release process of the encapsulated ingredients [
SLNs are produced by replacing the liquid lipid (oil) of an oil/water emulsion by a solid lipid or blend of solid lipids, giving particle sizes in the range 80–1000 nm, and which are dispersed in water or aqueous surfactant solutions [
SLNs are often produced by a melt emulsification followed by a hot or cold high-pressure homogenization (HPH) process. Briefly, the lipid phase is first melted at 5–10 °C above its melting point. The active ingredient to encapsulate is consequently dissolved or dispersed in the molten phase produced. Subsequently, a pre-emulsion is produced by stirring this melted phase in a hot surfactant solution. The pre-emulsion obtained is homogenized under high pressure to produce a hot nanoemulsion, which is further cooled down for the lipid recrystallization and the formation of SLN suspensions [
SLNs can also be obtained also by precipitation of lipids using water-immiscible organic solvents [
Different lipids can be used for the production of SLNs including triacylglycerols, acylglycerols, waxes and hard fats. Some examples of used lipids are given in the
Lipophilicity, purity, and crystallinity of the lipid material, are important factors in the selection of lipid and the production process. The solubility of the product to be encapsulated in the lipid phase drastically affects the loading capacity [
In order to improve the solubility of some active ingredients, a small amount of liquid lipid (oil) can be mixed with the solid lipid phase to obtain nanostucturated lipid carriers (NLCs). However, if a large amount of oil is mixed, a different type of nanostructures can be produced. Here, the solubility of the oil in the solid lipid phase is exceeded leading to a phase separation and producing oily nanostructures within the solid lipid matrix [
The purity of the lipids used can affect the zeta potential and therefore the stability of the SLN suspensions. For Intravenous (IV) administration of SLN suspensions they should be stable and toxicologically accepted [
In addition, these parameters are governed by the polymorphism of the lipid matrix. Polymorphism is the ability of the compound to crystallize in more than one distinct crystalline form with different internal lattices [
While conventional chemical synthesis is capable of improving the production of the solid lipid nanoparticles based on lipid drug conjugates; using covalent linking [
Generally, this type of supramolecular moiety looks like a flower vase or calyx krater and consists of several arene rings; hence, calix[n]arenes and calix-resorcinarenes, where "
As cyclodextrins are natural supramolecular macrocyclic oligosaccharides and their use in the area of nanotechnology has been reviewed by many groups [
The synthesis and the modification of various
SLNs based on
In order to demonstrate the potential use of SLNs based on
In terms of formulation optimization and stability parameters, different factors have been investigated by the group of Coleman [
The presence of certain surfactants for example, pluronic®F 68 led to a decrease in the particle size. This effect was related to the emulsifier and stabilizer roles of the surfactant, and was in a good agreement with results obtained for polymeric nanoparticles [
In view of the possible use of the SLNs based on
Generally, an increase of the agitation speed during the emulsification step leads to a decrease in the particle size for polymeric dispersions [
For SLNs based on
Dry formulations represent a stable dosage form for oral administration in the form of Tablet and for an IV administration in the form of suspension or solution after re-dispersion in water. Thus such water soluble dispersible powders represent potential additives for cosmetic and topical preparations. For these reasons, freeze-drying of the SLN suspension based on
Serum albumin and globulins represent the principal circulatory proteins with concentrations of about 46 and 27 g/L, respectively [
From PCS analysis, the diameter of the SLNs in absence of BSA was 150, 183 and 193 nm for
The dispersions were prepared in phosphate buffer saline (PBS) at pH 7.4 and standard methods for the determination of the haemolytic effect were used. SLNs based on
Because SLN suspensions have a low degree of crystallinity and thus the structure at the molecular level is largely unknown, NMR spectroscopy using hyperpolarized xenon (HP Xe NMR) [
The observed resonances at 0, ~20, ~80–130 and ~190 ppm were attributed to free Xe, Xe in the interparticle space, Xe interacting with the calixarene host cavity and Xe solubilized in the hydrophobic chains, respectively.
The increase of the shift of xenon interacting with the host cavity as a function of the number of carbons in the hydrophobic chains could be related to the reduction of void space for xenon in the host cavity. This relation between the shift and the chain length of the different
To study the interaction of the SLNs with small guest molecules, methylene chloride was used as an additive to the 129Xe/N2/H2 gas mixture; the results are shown in
DSC studies of the crystalline powder were obtained before and after the CH2Cl2 pulse (
These results illustrate three key features; firstly, host cavities were present at the surface of the SLNs and accessible to small chemical specii such as Xenon and CH2Cl2. The molecules were located in three areas: adsorbed on the surface, included into the cavities and entrapped in the SLN matrix, with each location giving a different release profiles. Secondly, the host cavities are loaded with hydrophobic chains of adjacent calixarenes, thus blocking the inclusion of the guest molecules. Thirdly, the pulse of a guest molecule led to the reorganization of the structure and therefore an increase the void site number for sorption.
Encapsulation in the solid state of different guests within the host cavities of the
Depending on the size and on the polarity of the guest as well as the crystallization medium, three types of solid structures are formed: (i) an interdigitated structure or partially self-included complex; (ii) open-container or head to tail complex; (iii) nanocapsular or tail-to-tail structure.
Aiming for a cosmetic application of the SLNs based on
From solid state studies [
Comparison of powder X-ray diffraction (XRD) patterns of unloaded SLNs, SLNs loaded with
With regard to possible use of the systems in magnetic resonance imaging (MRI), the encapsulation of the stable paramagnetic radical (4-methoxy-2,2,6,6-tetramethylpiperidine-
SLNs loaded with MT were prepared using the solvent displacement method [
In conclusion, the encapsulation of free radicals into the SLNs studied here can be considered as a first step towards the design of more sophisticated structures, where the properties of host and guest can be adjusted for each particular application. As examples, the authors envisage new magnetic materials, MRI contrast agents, in situ pH probes, or models for oxidation stress studies.
After the
However, in contrast to
A second functionalization at the lower rim was also investigated using different anionic and nonionic groups [
Moreover, The anionic derivatives
The synthesis of
The five obtained products (
Characterization of these colloidal particles was carried out using transmission electron microscopy (TEM) and PCS [
It was shown that the size decreases when the length acyl chain increases (from C4 to C12) [
With the surfactant (Pluronic ®F68) in the case of
As observed in the case of
The influence of the final concentration of
Numerous post formulation parameters were studied to demonstrate the possible use of this kind of colloidal particles for future biomedical exploitations [
Firstly, the influence of various mono and divalent ions on the stability of the SLNs based on
As seen for the SLNs based on
As indicated previously freeze-drying is the most commonly method to remove water from a colloidal suspension [
The interaction of the SLNs based on
The encapsulation capacity has been tested using
The amphiphilic dihydroxyphosphonyl-calix[
SLN suspensions based on amphiphilic dihydroxyphosphonyl-calix[
The diameter of the SLNs in pure water was 170 nm for
For SLNs based on
With a view to future biomedical applications, the interactions of the SLNs with the physiological cations, Na+, K+, Mg2+ and Ca2+ has been evaluated at concentrations of extracellular and intracellular levels [
Non-contact mode AFM imaging showed clearly aggregation when compared the SLNs based on
Amphiphilic 5,11,17,23-tetramino-25,26,17,28-tetradodecyloxycalix[
SLNs based on
Due to their cationic nature, the SLNs based on
To confirm the absorption of the first layer of DNA at the surface, the SLNs were incubated with increasing concentrations of plasmid DNA. Electrophoresis (
Moreover, the study of the electrophoretic mobility (ζ potential) showed that the surface potential values of the coated SLNs with the DNA decreased from +44 to −42 mV when the amount of DNA increased from 0 to 20 μg/mL (
In addition, it could be seen that at 5 μg/mL of DNA a slight positive value of +1 mV was occurred [
Cell transfection was studied by incubation of coated SLNs with MDCK (Madin-Darby canine kidney Cells). The transfection rates were evaluated by the fluorescence of a green fluorescent protein (GFP) for which the loaded DNA codes and compared to the transfection rates obtained with a reference method (Lipofection). The results presented in
Cell transfection was visualized by coupling chitosan to a fluorescent dye (tetramethylrhodamine) and the cell was then imaged by confocal microscopy. The results presented in
Amphiphilic 5,11,17,23-tetra-carboxy-25,26,27,28-tetradodecyloxycalix[
Formulation of SLNs based on
SLNs were prepared using the solvent displacement method [
Since this type of colloidal particles are based on a calix[
Resorcinol-dodecanal cyclotetramer,
SLNs based on
From the above result, an SLN suspension was formulated with 10% (
In order to optimize the formation of this kind of SLNs, different studies were undertaken [
Regarding the influence of the viscosity of the aqueous phase, varying concentrations of glycerol were used. The results show that at low concentrations of glycerol, the size increases and this peaks at 4% size decreasing to the value found in the case of pure water (150 nm) at 10% of glycerol. This complex result is in contrast to the observations in the cases of
At final concentrations of SLNs above 100 mg/L the diameter increased progressively to reach a value of 180 nm at final concentration equal to 300 mg/L. This result was in contrast to other calix[n]arene derivatives, where the size increases up to 300 mg/L in the case of
The situation in the case of calix[n]arenes and calix[
For future applications, the effects of various sodium and potassium salts at 0.1 M on the suspension stability were studied [
The effect of the microwave irradiation, ultrasonic and thermal treatment was also tested and showed no change in the stability [
Freeze-drying of SLNs based on
SLNs based on
The amphiphilic properties of
SLNs based on
PCS analyses of these particles showed no significant change in term of particle size after chemical modification and the value was 200 ± 5 nm. Furthermore, non-contact mode AFM imaging was undertaken to confirm this result. In this case, anti-BSA antibodies were immobilized on functionalized gold, and then incubated with proteo-SLNs suspension [
SEM imaging has also been used and the result is presented in
Tetramethoxy resorcinarene bis-crown ethers (C3BC5, C4BC5, C5BC5, C7BC5 C9BC5, C10BC5 and C11BC5) syntheses were carried out using a cesium carbonate mediated coupling with a suitable tosylated oligo-ethylene glycol [
SLNs suspension based on
The effect of length of the alkyl chain and the final concentration on the particle sizes of the suspension has been studied [
This result was in contrast to the observation obtained in the case of
After the first study of the SLNs based on
Proposed structure of solid lipid nanoparticles (SLNs), the interior structure varies from amorphous to crystalline.
Synthetic route to different amphiphilic structures based on calix[
Non-contact mode atomic force microscopy (AFM) images of
Formulae of
General formulae of the amphiphilic calix-arenes used in the haemolysis experiment.
Chemical structures of amphiphilic calixarenes.
Differential scanning calorimetry traces for
Top view to the cavity of
Structures of
Capsular structure of inclusion complex of
Powder XRD patterns of
Structures of
Electron spin resonance (ESR) spectra of SLN of
Synthetic route to the amphiphilic
Synthetic route to the compounds
Noncontact mode AFM image of the solid lipid nanoparticles formed by
Non-contact mode AFM image of the solid lipid nanoparticles formed by
Variation of the diameter of solid lipid nanoparticles formed by
Variation of the diameter of solid lipid nanoparticles formed by
Noncontact mode AFM image of the solid lipid nanoparticles of
Synthetic route to
Atomic force micrsocope image of
Agarose gel electrophoresis of
ζ-potential values for
ζ-potential values during the LbL formation; +D: DNA addition; +C: chitosan addition [
Transfection rates of MDCK cells, normalized with the values obtained for lipofection experiments, using SLNs coated with DNA (
Confocal micrograph of a transfected cell that has expressed green fluorescent protein (GFP). The red color representing the labeled-chitosan appeared to be in the cytoplasmic compartment of the cell [
Chemical formula of 5,11,17,23-tetracarboxy-25,26,27,28-tetradodecyloxycalix[
AFM images of a suspension of
Molecular formula of para-
Non-contact mode AFM image of
Formula of
Non-contact mode AFM images of
Non-contact mode AFM images of SLNs based on mixtures of
Synthetic route to
Scanning electron miroscopy image of
Non-contact mode AFM image of
Schematic representation of the proposed interaction mechanism. The lateral chain of Phe is represented by a dashed line for the
Synthetic route to proteo-SLNs
Non-contact mode AFM of proteo-SLNs immobilized on a gold surface via antibody-antigen interactions and schematic representation of the strategy used to attach the SLNs on the surface (
Scanning electron microscopy image of proteo-SLNs spread on a glass substrate (scale bars 1 μm and 200 nm (inset)) [
Structure of the resorcinarene bis-crowns CNBC5
SEM image of C11BC5 SLN on SiO
SLN diameters for all CNBC5
Lipids commonly used in the preparation of solid lipid nanoparticles.
|Melting point
|Triacylglycerols (Ester derive from glycerol and three fatty acids)
|Acylglycerol mixtures (Ester of the alcohol glycerol in which a hydroxyl group is replaced by a fatty acid)
|Waxes (Ester of a long chain alcohol and a fatty acid)
|Hard Fats (Saturated fatty acid)
Hydrodynamic diameter of the different
|Average hydrodynamic diameter (nm)
Results of the haemolysis experiments (expressed as a percentage of total haemolysis caused by hypotonic stress) at calix-arene SLN concentrations varying from 50 to 150 mg/L, values are derived from the O.D. measured at 540 nm.
|Concentration mg/L of SLNs
We thank INRAP for funding for I.M.
The authors have no of conflicts of interest for this publication.


text:
The group posted net losses of $301m (£163.5m) for the three months to 30 June, against a $50m profit in 2005.
The company is in the middle of a huge restructuring plan costing 5,000 jobs, as part of a bid to end five straight years of losses.
Excluding one-off costs, the group would have broken even as sales increased 15% to $1.81bn.
Elsewhere, revenues rose 29% $3.83bn from $2.97bn, topping analyst expectations of $3.6bn.
Business improving
"We're making excellent progress returning Sun to growth and profitability," chief executive Jonathan Schwartz said.
"Revenue, bookings and backlog are all up substantially - indicating we're gaining traction, market confidence and share."
Sun had warned the shake up of the company would cost at least $500m in coming quarters when it launched the revamp in May.
In the latest results, restructuring costs came in at $288m.
By trimming 13% of its workforce, the group expects to yield annual cost savings of up to $590m.
Most Popular Now | 56,514 people are reading stories on the site right now.";


text:
Browse By Person: Harvey, Tracey
|Up a level
Group by: Item Type | Date
Jump to: Book Chapter | Journal Article
Number of items: 5.
Book Chapter
Bui, Loan Thuy, Clements, Judith, Dong, Ying, Harvey, Tracey, Jarrott, Russell, & Walsh, Terence Patrick (2003) Production and characterization of antipeptide Kallikrein 4 Antibodies: Use of computer modeling to design peptides specific to Kallikrein 4. In Russell, P, Jackson, P, & Kingsley, E (Eds.) Prostate Cancer Methods and Protocols. Humana Press, Totowa, New Jersey, USA, pp. 241-254.
Journal Article
Dong, Ying, Matigian, Nick, Harvey, Tracey J., Samaratunga, Hemamali, Hooper, John D., & Clements, Judith A. (2008) Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function. Biological Chemistry, 389(2), pp. 99-109.
Clements, Judith, Hooper, John D., Dong, Ying, & Harvey, Tracey (2005) The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions. Biological Chemistry, 382(1), pp. 5-14.
Hooper, John D., Bui, Loan T., Rae, Fiona K., Harvey, Tracey J., Myers, Stephen A., Ashworth, Linda K., et al. (2001) Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate amd skeletal muscle. Genomics, 73(1), pp. 117-122.
Harvey, Tracey J., Hooper, John D., Myers, Stephen A., Stephenson, Sally-Anne, Ashworth, Linda K., & Clements, Judith A. (2000) Tissue-specific expression patterns and fine mapping of the human Kallikrein (KLK) locus on proximal 19q13.4. The Journal of Biological Chemistry, 275(48), pp. 37397-37406.


text:
It would be like cracking a nut with a steam hammer for you to devote your brains to this case.
In the German way they had used a steam hammer to crack a hickory nut.
In fact it was the steam hammer which first rendered the large steamship possible.
Like Tubal Cain of old, they welded molten iron into form and shape, long before the steam hammer was thought about.
For cutting off under the steam hammer, the hack shown in Fig. 2879 is used, being simply a wedge with an iron handle.
It was like killing a butterfly with a steam hammer, to loose so much vengeance against this frail piece of china.
Mr. Nasmyth not only invented the steam hammer, but the steam pile driver as well.
For instance, we saw a man straightening the rails with a steam hammer; it was very skilled work, and I was told he was making 7d.
To the steam hammer we owe the first heavy armor plate for our battle ships and the propeller shafts of our earlier steamships.
The same principle gives high economy to the steam hammer and pile-driver of Nasmyth.


text:
by Jay Younts of Shepherd Press - Will your words save your child's life? If you speak the truth in love from your heart and the power of Scripture, … [Read more...]
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Future Husbands: Your Future Wife Does Not Belong to You
by Samantha cross posted from her blog Defeating the Dragons So, I keep swearing to myself that I won't keep writing reactionary posts. I do. I really do. I make all these beautiful promises about keeping my head down, not getting involved when someone says something unintelligent . . . … [Read more...]
Quoting Quiverfull: Biblical Character?
by Jeff Owens of Bible Believer Net - The Attributes of a Wife Who Possesses Character 1. A wife with character will be in submission to her husband, … [Read more...]
Quoting Quiverfull: Stuffing the Ballot Box With Arrows?
by Colin Campbell in Meat For Men It is foolish of the church to adopt the world's mindset and limit the arrows in their quivers to one or two per family. … [Read more...]
My Birdie
by Mari cross posted from her blog Mari's MusesI got a parakeet last week.Solomon is a beautiful shade of blue. … [Read more...]
Quoting Quiverfull: A Guarantee?
by Johnathan Lindvall from his Bold Parenting Seminar Even in a case where you know you are right, are you willing to give up … [Read more...]
The Hotline Project
Recovering From Religion is in the process of fundraising for their Hotline Project, a 24 hour 7 days a week 800 number to help those struggling with support and local community resources to help on their journey out of spiritual abusive situations and churches.We wholeheartedly endorse the Hotline Project because it is a very needed resource. Like RFR our site gets emails from those seeking help on their journey, but we don't have the resources to help out as much as we'd like or that is needed. Make no mistake, the need is great! Please consider contributing. … [Read more...]
Quoting Quiverfull: Good, Better or Excellent?
by Mary Pride of Homeschooling World -"Good, Better or Excellent?" I now would like to say that the time has come to stop thinking about being "as good as" or even "better than" the public schools. … [Read more...]
Why Are We Leaving the Church?
by Samantha cross posted from her blog Defeating The Dragons[I originally wrote this for Christianity Today's her.meneutics after my pitch was accepted, but they have decided not to publish it, so I've decided to post it here.] … [Read more...]
Quoting Quiverfull: Denying Homeschooling Causes Riots?
by Vaughn Ohlman from Persevero News "The Wrath of God vs Sweden" The wrath of God has been revealed in Sweden. And as it is in Sweden, I believe it will be in Europe. … [Read more...]