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News & Events
Scott Gottlieb, MD - Northwestern University Medical Center
This text contains Dr. Gottlieb's prepared remarks. It should be used with the understanding that some material may have been added or deleted during actual delivery.
Speech before
2006 Clinical Research Educational Conference
Northwestern University Medical Center
Chicago, Illinois
Remarks by
Scott Gottlieb, MD
Deputy Commissioner for Medical and Scientific Affairs
May 18 , 2006
Thank you for having me here today.
We are entering a once-in-human-history opportunity for progress in the life sciences and their application to human health. We have seen life expectancy come close to doubling in the last century, from the mid-forties to the long life expectancies that await many of us here today. And many are convinced that when our present history is written years from now, one of the most significant pieces in that history will be the ability of all of us for the first time to comprehend the origin of diseases, to influence human health, and to develop on a scientific basis the means of preventing and even curing disease.
A lot of this progress owes to recent advances in genomics and proteomics, and the onset of a stage where we can develop therapies for disease that are based not on trial and error, but on rigorous deductive methods.
Over the last decade or so, this promise and the reality of basic biomedical research has been so exciting, so captivating that it has received the lion's share of attention from the public.
But the fact is that without a robust clinical research enterprise, much of what we learn through basic research cannot be applied effectively and efficiently to advancing the public health. And improving the public's health is what biomedical and health sciences research is ultimately all about.
The good news is that we are seeing far more emphasis on translational research, on taking the results of science directly to patient care.
But even while we have strengthened the bonds between clinical research and the practice of medicine, we still need to do more to also strengthen the bonds between basic science and clinical research, and to take advantage of modern tools and approaches to collecting and communicating clinical information.
Not enough has been done, or is being done, to modernize our approaches to clinical research, to take advantage of new scientific tools and new discoveries that can improve the way that we evaluate new medical products.
Some of this is because the tools that we use in the drug development process itself are in many cases outdated, whether it is a clinical trial endpoint or the way the trials themselves are being designed and executed.
Even while we have poured billions into the science of discovering new drugs, we have invested comparatively little in the science of how we go about actually testing and evaluating those drugs for safety and effectiveness. This is a problem that we are addressing at FDA, under the leadership of FDA's Chief Operating Officer Dr. Janet Woodcock and others, through our Critical Path initiative, something I want to get back to in a few moments.
But even while we work to improve the actual scientific tools being used in the drug development process -- whether it is the validation of PET imaging as a better marker than plain film x-rays for measuring tumor shrinkage in trials of lymphoma drugs, or the creation and corroboration of a new assay for measuring drug side effects like liver and heart toxicity -- there is another place where we all need to work together: to develop better scientific tools and approaches for doing clinical research itself.
The fact is we are failing to modernize our approaches to clinical research, not just in how we collect clinical information but how we communicate it.
We – all of us – are dealing with four problems
First, in many cases, are not taking advantage of modern tools of information technology to improve the way we conduct and monitor clinical trials.
Second, in many cases, we are not taking advantage of these same tools to improve the way that we collaborate.
Third, we are not evolving the way that we structure clinical trials to leverage new insights into biology and genomic and proteomic predictors of peoples' propensity to develop disease or respond to a particular treatment.
Finally, in many cases, we are not incorporating new information tools to improve the way that we communicate and share the results of clinical research.
We cannot afford to ignore these challenges. With the cost of developing new medical products continuing to increase, by some estimates it now costs more than $1 billion to develop a single, novel new drug, and with more and more potential breakthroughs taking longer to reach patients who need them, we need to take new steps to make the clinical research process more efficient and effective.
We simply must look at how we can leverage new technologies, new collaborations, and new scientific opportunities to improve the clinical research enterprise, if all of that basic bioscience being developed on the front end is going to be translated into safe and effective medical solutions for patients. Otherwise, clinical research itself may well become the bottleneck in the future to taking advantage science to improve health.
I want to talk about each of the four critical areas I outlined where we need to take new steps to improve the clinical research process, and tell you about some of the things that FDA is doing to address them by making better use of modern tools and approaches.
And I want to tell you where I believe we are going to need your help.
First, on improving the conduct and monitoring of the clinical trials themselves:
As clinical trials continue to evolve, in particular becoming increasingly large, decentralized and global, the FDA's approach to bioresearch monitoring and human subject protection must also evolve and modernize.
Our regulations were written and structured and put in place many years ago, and since then clinical trials have changed a lot.
We need to make sure we are continuing to provide appropriate, risk-based safeguards, while also making sure that FDA is not an obstacle to progress in the design and conduct of clinical research.
There are new trial methods and designs, new methods of data collection, and new arrangements between sponsors and various contractors, among investigators, among institutions and among institutional review boards (IRBs). There is the rise of free-standing, for-profit study centers.
Many of these are positive developments. But these changes, the development of the clinical trials enterprise, challenge us to also adapt our approaches to how we oversee the clinical trials process. We need to modernize our approaches to accommodate and leverage this new landscape for clinical research.
So we have undertaken a new initiative called BIMO to do just that. I'll give you some examples of some of the questions we'll be working to answer.
For one thing, less frequently are clinical trials conducted at a single site, or a few sites. Often trials will involve 30 or 40 different sites, or more. Is it possible, reasonable or appropriate for a single principal investigator to oversee all those sites? How should FDA ensure that there is adequate and appropriate supervision at all sites? And, if an individual other than the PI is performing and integral and essential role in the trial, should that individual not be responsible and accountable to the FDA? We will be asking these questions, and also developing guidance on what we view as adequate supervision by the principal investigator to help address this latter question.
Another question we will be asking is what does it mean to keep a record electronically, where results like ECGs might be generated and fed directly into a central electronic database? In these cases, who is responsible for looking at these results to make sure that there is no medically urgent information contained on it? And what does it mean to retain more than one record in that case? These and other questions become increasingly urgent as we all move more fully into the electronic era.
Other things we might consider are more real time inspections of clinical trials sites rather than post-hoc audits, and how we can better capitalize on inspections we know industry is already doing, to better leverage these resources.
We will also be providing common standards and regulatory requirements for electronic data handling. And we will be developing guidance to better delineate the proper role of IRBs, and specifically on what adverse event information we think should be reported to IRBs from clinical trials.
Now for the second issue: collaboration.
To improve collaboration across the clinical research enterprise, we need to take new steps to make more effective use of information technology in order to create easier, less expensive ways of collecting and sharing clinical data.
Collaboration in medicine, and clinical research in particular, is increasingly done across electronic networks, facilitated by advances in medical computing and the growing adoption of electronic health records. To help capitalize on these advances, at FDA we are working on clinical research data standards and standards to help facilitate the exchange of data.
We are also working to harmonize these activities with the growing use of electronic health records. And we are taking new steps to standardize the input of a lot of the clinical trial information, such as the case report forms, to make collecting and sharing and reporting information easier and more effective.
In addition, insufficient attention has been paid to incorporating clinical research findings into clinical practice. Integrated health systems and practice-based networks also offer rich potential for the kinds of population-based research in "real world settings" that form the foundation of evidence-based medicine.
We need to more quickly adopt strategies to take advantage of these opportunities, including promoting mixed academic and non-academic clinical trials, and creating incentives that encourage collaboration in clinical research among academia, industry, private health providers, and managed care. Most of this does not involve FDA regulation or things that we can do at FDA to help facilitate the exchange of information, but sometimes it does.
We will have more to say on the subject of population-based data soon, including guidance we hope to be able to develop that will outline good principles for making rigorous use of the growing collection of population-based data being accumulated in large databases, especially among payers.
With the growth of large population-based databases, there is an increasing temptation to do retrospective studies that are sometimes underpowered and poor quality and not as useful as possible. We hope to be able to issue guidance on what we believe the proper and rigorous use of epidemiological databases is, especially for finding important safety signals.
On the third point I outlined at the outset, we need to take advantage of new discoveries in basic science such as genomics and proteomics to modernize the way that we approach clinical research and the way that we design clinical trials.
In recent years, we have seen a lot of advances in our ability to use tools such as gene and protein markers to help predict not just who is at higher risk to suffer from certain health events, but also, in some cases, who is most likely to benefit from a certain medical intervention.
We need to leverage this new scientific information to improve the way we structure and conduct clinical research. For example, early on, when you are conducting a clinical trial to investigate a new medical product, you want to do studies in people who have a lot of the events you are interested in studying, and if possible people who stand a better chance of realizing more of the benefits, and fewer of the side effects of a drug you are giving them.
The genomic revolution and the proteomic revolutions are already making these things possible. But we will need to work together to enable these public health opportunities to inform how we work as clinical researchers, and how we work as regulators. This is the most immediate impact that genomics and proteomics will enable – the ability to identify people at greatest risk of bad outcomes and to identify people capable of responding to a treatment, both related to a growing mastery of mechanistic data rather than continued reliance on the highly empiric approach that we use today.
There are dramatic examples of how making better use of this science in the clinical research process can enhance efficiency, and improve health outcomes.
In oncology, the classic example of where these kinds of tools can improve clinical research is the drug Herceptin. This drug, for the treatment of breast cancer, was evaluated in clinical trials in people with the HER2 receptor; the receptor toward which Herceptin is directed. This allowed researchers to avoid testing the drug in patients who would be likely to experience benefits but could still experience the drugs potentially serious cardiac adverse effects.
Also if the original trials had included the roughly two-thirds of people who were not HER2 positive, it would have been harder to show that drug worked at all, requiring a larger, longer clinical study than the one FDA needed ultimately to prove that the drug was highly effective. By focusing on people with factors like HER2, who are pre-selected because of their ability to respond well to an intervention, you make the effect size larger which means you can study a smaller population and expose fewer patients to experimental treatments.
Another example in oncology is with the drug Tarceva. While there are ongoing debates about what measurement of EGFR correlate best with response to that drug, at a more basic level, it is widely appreciated that measurement of the amount of EGFR receptors on cancer cells correlate with response to the drug and this is reflected in labeling.
There are also many indicators of likely events already in use, for example people with high lipids, recent infarction, diabetes, and other risk factors are more likely to have a heard attack then others and such selection criteria are regularly incorporated into trials. There will surely be new genomic and proteomic predictors of risk that can be used similarly.
Enriching trials based on these kinds of markers, is something that FDA is actively encouraging sponsor to do. Particular promise for this kind of work clearly rests with oncology, because what is a tumor but a genetic abnormality. But the principles apply to almost any therapeutic space.
We have already shown we are willing to look at results from enriched clinical trials, especially when there is a strong response in an unmet medical need, in something other than the entire potential population, and to allow results generated from at-risk populations, that are pre-selected based on good science, as the basis for labeling. The extent to which labeling would focus on the particular group studied or be generalized depends on the particular case, but clearly the outcome data even in a subset is of great importance.
For example, the very first showing that the hypertension drugs known as ACE inhibitors could prevent death in people with heart failure was done in highly selected population, people with advanced and severe heart failure. In fact, this first outcome study that showed the drug improved survival was in the CONSENSUS study; a study with only 253 people, but the magnitude of the effect was very large, and so we wrote that result into label right away.
Given the magnitude of the potential for benefit, we did not wait and say we would not know how the drug would work in people who were less sick.
There are a lot of other very interesting opportunities to extend these principles, and a lot of promise from advances in genomics and proteomics that has not yet been fully realized. This will also help address another critical challenge, the agonizingly slow pace and low levels of recruitment for clinical trials. A recent survey by the American Society for Clinical Oncology for example reported that fewer than four percent of eligible cancer patients participate in clinical trials.
To help facilitate these approaches to clinical trial design, we are in the process of developing a guidance document specifically on enrichment in clinical trial design and how sponsors can take advantage of these opportunities.
There are a number of issues where we believe, through better guidance to product developers and researchers we can help facilitate advances in enrichment designs. For example, how much data do you need on the "off" subset, the people who do not have a high level of whatever marker you are using to enrich your trial population.
Some of our best opportunities for developing novel treatments for unmet medical needs, and doing so in a way that is efficient and does not make us expose people to experimental drugs unnecessarily, all rests with our ability to develop better, well validated approaches to structuring clinical trials. This is a major part of our Critical Path initiative – to develop better science on more adaptive clinical trial designs that allow us to incorporate what we understand about patients and about therapies into how we design clinical trials.
Finally, on the topic of communication:
When it comes to how we share and communicate the results and findings of clinical research -- I believe there is a lot more we can do to improve the transparency around the information that gets generated from clinical research, as well as the tools and approaches we use to make this information available to patients and doctors.
We need to make more of this information available at the time and the place where people are confronted with a medical decision.
Right now, when you are a doctor practicing medicine, bottom-line information is not easily accessible when a medical question comes to mind.
Even when this information is accessible, the specific facts that are relevant to a doctors' particular medical specialty is not always easy to pick out from the reams of general medical information that is available.
A cardiologist for example is inundated with warnings and writings about psychiatry drugs while surgeons get deluged with data on diabetes. Moreover, matching up a patient's particular characteristics which the subtle signals and data nuggets that might alert doctors to a rare problem is not as easy as it should be.
We need to use the same information technology that is becoming commonplace in clinical research to improve clinical practice, and the way that results of research can supplied to physicians.
We need, for example, a system where the same IT tools are able to keep track of this medical information, and readily integrate updates, and then seamlessly alert doctors to new information, and the most relevant facts for each individual medical encounter. This is the system everyone envisions. It is true that the bottleneck to these kinds of systems have been the lack of information technology tools, and the widespread adoption of electronic medical records that make archiving and retrieving this kind of data possible.
But the problem has not only been about hardware and software, but also about the absence of the right data in the right formats.
This is where FDA can help. We are fundamentally in the business of turning raw medical data into useful knowledge about medical products. For many years, we did not do as good of a job as we could have of sharing this knowledge widely. In some cases, we did not have the resources, but in others we just did not think we had to. This is another place where information technology tools are also helping.
With advances in the way that doctors and patients retrieve medical information, at FDA we have been able to fundamentally re-think the way we provide it. And we are doing just that. Let me tell you how.
Starting last November, healthcare professionals, patients, and other consumers have been able to access high-quality, up-to-date information on medications via the Internet free of charge through the Daily Med system, which receives, distributes and displays medication information that has been developed by Federal agencies. This is a monumental change in the way medical information is made available that would not be possible without the leadership and hard work of the professional staff at FDA's Drug Center and especially my colleagues Dr. Janet Woodcock and Dr. Steven Galson.
A key element of the Daily Med is the electronic product label, known as the package insert or the physician label. This is the onion-skin piece of paper folded up inside the tops of your pill bottles. Until now, the content and format of these paper labels was not conducive to easy accessibility, and they were not easy to search to find the most pertinent information. It was hard to even find them on the web. Often, getting an electronic copy of the label meant downloading a PDF file.
So we recently released a new rule that will fundamentally re-make this package insert, or the physician label, making the information that is provided more readable, more accessible, and more amenable for electronic dissemination.
This is an important step toward creating an electronic environment for drug safety and drug effectiveness information that will make it easier for doctors and patients to get up-to-date information right at the point of care.
There are many other steps we are taking.
We recently required drug makers to start submitting label changes electronically in a standard format that, after verification by the FDA, will make updating labels with new information seamless, and automatic. Imagine a world where the most relevant information in the product labels, for example new updates or the most common side effects or the prescribing information, can be easily pulled off the web or better yet, pushed to a doctor on her PDA.
You can be instantly updated each time new safety warnings are added or new information about a common drug's benefits. Doctors could receive special alerts for the drugs they are most likely to prescribe.
In addition to these things, FDA is taking other steps to help build the systems, infrastructure, data standards, and strategies to support and sustain the management of that information well into the future. We are modernizing our system for reporting drug safety information, called Med Watch, into a new system that we creatively dubbed, "MedWatch Plus." We will be expanding on-line reporting, increasing interoperability, and moving toward a consolidated system for reporting all adverse events across the agency.
Another program we will be launching is a new, regular report on drug safety that is generated from the Med Watch surveillance data that we receive. It will be similar to the Morbidity and Mortality Weekly Report that is published by the C.D.C. This will help better inform doctors, more regularly, about what we are finding.
FDA already reports on the data in Med Watch, but right now this information comes out quarterly. By making this information available more regularly, our hope is more doctors will be prompted to report more of what they are finding. We should be able to release more bottom line medical data more quickly while protecting commercial confidential information.
All of these initiatives, as well as several others, together make up what we are calling Facts@FDA – a new electronic architecture for making timely, reliable information available to doctors and patients when they need, where they need, on demand. Taken together, these efforts comprise a big step into the future of healthcare information, a future when medical decisions can be guided by the most up-to-date and reliable information possible.
Finally, there is one more issue I want to discuss in closing, that also has to do with the way clinical information gets communicated to physicians and ultimately, to patients. That is the important role that the medical journals play in evaluating and promulgating the results of clinical research.
Medical journals -- both general and specialized -- have a vital part to play in shaping the views and behaviors of scientists, clinicians, and policymakers about medical practice and health policy issues of importance and concern. They can often serve as a bridge between these sometimes disconnected communities. They help put clinical and scientific findings into a common, practical focus.
I have served on the editorial staff of two major medical journals and consider myself a friend of these institutions. My esteem for the medical journals and their unique mission is why I have been deeply disappointed by some of the recent practices and pronouncements of some of our leading medical journals.
Editors of major journals have espoused greater transparency in the clinical research system, and that is a necessary end. But journals are not doing enough to adopt these same principles. Instead, the journals have enhanced the value of their franchises by maintaining very strict embargo policies, and long publishing cycles, that can bottle up clinical results for months and in rare cases years.
That can have public health consequences.
Now don't get me wrong, the peer review process, although sometimes needlessly long, can serve medicine well by making sure that the medical results that get published and relied upon by millions of doctors have undergone close and expert scrutiny.
It is also true that FDA has its own peer review process where medical decisions undergo review by senior scientists, and sometimes are the subject of large regulatory briefings and meetings inside our drug center. Difficult medical questions get hotly debated by our career scientists and our medical staff.
In fact, the culture inside FDA is very similar to the culture inside any medical institution, including the medical journals, where we are required to reach scientific consensus around complex medical questions. No one person possesses all the necessary expertise and information, especially on complicated drug safety questions. It is for this reason that we have recently gone to new and great lengths to be more transparent about our deliberations, and to put in place processes that help resolve scientific disputes by allowing people to have individual scientific opinions strongly considered, especially diverging views.
But when it comes to the medical journals, my concern is this: The medical journals cast blame for the time it takes others, including FDA, to scrub medical information and put it through rigorous peer review before communicating final conclusions. Yet the journals themselves often take months to catalogue, review, format, and publish the articles they get submitted to them and are sometimes slow to update these articles when new findings emerge.
I think there should be a level playing field across the clinical research enterprise that engenders a culture of transparency around research results. And I think there should be a sense of immediacy shared across institutions involved in the research enterprise, FDA included, where important results are communicated more quickly, and important updates are made when medical information evolves.
A number of journals are starting to web-publish many more of their most important studies. This is an encouraging development. Clinicians and patients deserve nothing less than timely, complete information around the results on which they base their medical decisions. It is worth pointing out that some journals have also recently talked about developing more transparency around their peer review process as well, including more disclosure and transparency around their peer reviewers, who are often the same outstanding and principled experts FDA also relies on for public input at our advisory committee meetings.
To these ends, FDA has also worked hard to achieve greater transparency in its review process as well as around its own advisory committee process and especially the way that it discloses findings about the safety of medical products. We will continue to make these goals among our highest priorities.
But because we are all so dependent upon the work that the medical journals do, I also think the medical journal should be doing more to adopt these same principles in their own work, to foster a culture of trust, and to create a more level and transparent playing field for information. They should take a lesson from others who have made great strides in these areas, and commitments to these goals, sometimes at the journals' own prompting – and that includes the FDA.
Private biomedical research has flourished under a largely self-governed arrangement, yielding immense benefits to society. But this arrangement relies upon a public trust that can sometimes be quite fragile.
At FDA, we are equally committed to these goals, and to adapting our own regulatory approaches in ways that accommodate good scientific ideas and new innovations in clinical research. Only by leveraging better scientific approaches in how we develop medical products, will we be able to see the benefits of all of the recent advances that have been made in basic science turned into practical medical solutions and advances in the public health. Thank you.


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It is a misdemeanor ticket. Police described it as a "traffic citation" How will it affect my nursing license & if I plead not guilty, is there a chance the judge will lower the charge? No prior record.. thanks for the help.
The police described it as a "traffic citation" because they didn't want to scare you. However, citations can still involves serious charges and your case is a serious charge because of the impact on your nursing license. Unfortunately, the judge cannot lower the charge. If you want the charge dismissed or altered, you will need to negotiate a deal with the DA's office and that usually requires having an attorney represent you in court. Getting the right deal in court will be helpful to prevent consequences to your nursing license, so getting a good criminal lawyer will have a positive impact on your licensing issues. However, you may want to consult a licensing attorney as well when the time comes.See question
I have been arrested first time for DUI on May 19, 2012 by Costa Mesa PD. Scheduled in Harbour court on 29 June 2012. I was not pulled over but had an accident where only myself involved. Nobody injured. Breathalyzer resulted in .12 & .14 30 m...
If you're still looking for a criminal defense attorney, don't hesitate to give me a call to set up a free consultation. Not only is my office directly across the street from the Harbor Justice Center (and I'm there all the time), but as a former Deputy District Attorney, I know exactly what the prosecution is looking for and how to present your case for the best possible defense. I have a perfect 10 on Avvo (as you can see from my profile), I focus 100% on criminal defense and DUIs, and OC Metro Magazine ranked me as one of the top 5 DUI defense attorneys in all of Orange County (August 2011 issue).See question
I don't want DMV to suspend client's license for 1 year as a result of this violation. Client has been offered this "DEJ" program, but was wondering if the DMV would find out about the initial, conditional guilty plea? Please advise.
The DMV cannot find out about a conditional plea. The only way that DMV ever finds out about anything from the criminal courts is when an abstract of a conviction is sent to them by the clerk's office. No conviction, means no abstract, means no discovery by the DMV.See question
Hello, I was recently arrested at JCPenny for items valued at $80.00. I am facing two misdemeanor charges of burglary and petty theft. This is my first offense. I'm guessing they charged me with burglary because I came in with an empty shopp...
It is theoretically possible for the charge to be reduced to an infraction, but doing so depends on a variety of factors, including the particulars of your case and the personality of the DA. Another option may be to negotiate for some kind of diversion -- where you plead guilty up front, jump through some hoops, and then get the charges dismissed prior to sentencing. I have negotiated that type of resolution before at the Bellflower court, but it had more to do with the specific DA I was dealing with than the charges. I highly recommend hiring an experienced criminal defense attorney to handle your case from the beginning. As you admit in your question -- it's your career on the line. You may contact me or any other Los Angeles attorney on Avvo that has a good rating.See question
he has a court date set for that what can we expect that day?
I agree with the above answer except for one distinction. Mr. Kaman assumes that your husband is already in custody but I can't tell that from the question posted. If your husband remained out of custody after the preliminary hearing, then he will most likely remain out of custody after the 995 motion. If he was taken into custody after the preliminary hearing or he was already in custody at the time of the preliminary hearing, then he will most likely stay in custody if the 995 motion is lost.See question
for a self defense case
I agree with the above answer except for one distinction. Mr. Kaman assumes that your husband is already in custody but I can't tell that from the question posted. If your husband remained out of custody after the preliminary hearing, then he will most likely remain out of custody after the 995 motion. If he was taken into custody after the preliminary hearing or he was already in custody at the time of the preliminary hearing, then he will most likely stay in custody if the 995 motion is lost.See question
Recently I got a wet reckless with 2 years of probation. I also want to apply for naturalization as I'm qualified. I was advised not to apply while I'm on probation and I was wondering if I could shorten this period and on what bases.
Actually, it's good advice because you can't apply for a change in immigration status while on probation. You will NOT get naturalized if you are on probation. Only if probation is terminated, either naturally or through an early termination of probation, can you then apply for naturalization. The above attorneys gave good advice as to how to go about getting an early termination of probation -- you will need a criminal defense attorney to help you do it. And then I highly recommend hiring an immigration attorney to help with your naturalization, given that you have a criminal background. By the way, terminating your probation will allow you to expunge your case early. But while an expungement may help with employers, your expunged conviction must still be disclosed to immigration authorities.See question
im 22 and i have no record how much time am I looking at if convicted.
I agree with Mr. Dane's answer completely. I would also add that once you hire a competent defense attorney, you may be required to pay additional funds to retain a private investigator. These types of cases sometimes require independent investigation. I don't know what your financial situation is, but you can't afford to skimp on hiring quality legal representation.See question
I was previously arrested for intimidating a witness. The Private Investigator was able to get enough proof to show that I was innocent. The person who made the false allegation was my husband's ex wife and her family. My husband was also arrested...
Unfortunately, you can't prevent her from making the allegations but you can protect yourself. Hiring a PI is a great move. Be prepared to file a protective order against her. If your husband is the one that files for the protective order, he can file it as a domestic violence protective order since they had a romantic relationship at one point in time. Then, he can add you as a protected party on that order. If you file the protective order, it would be filed as a civil harassment protective order. The domestic violence protective order is better because it's easier to prove. Your husband only has to show harassment by a preponderance of the evidence, but you would have to show harassment by clear and convincing evidence. I would recommend hiring an attorney familiar with restraining orders to assist you. Most family law attorneys and some criminal defense attorneys (like myself) have a restraining order practice. Accusing her of filing a false police report is difficult, but if the police are involved, I would certainly make her prior false allegations known.See question
i had a dwi in tx, case resolved but they assigned surcharges. thing is i never had a tx DL, i had and still do have a CA license. am i to pay charges to texas or else the ca license gets suspended? is there reciprocity between those...
There is reciprocity between most states under the Interstate Driver Compact. So if you run into problems in one state and your privilege to drive is suspended, then that state will notify the other states and your privilege to drive may be suspended in other states until you clear the problem in the first state. Also, in California, your privilege to drive may be suspended even if you never had an actual driver's license. The same may be true of Texas -- you should consult with a Texas attorney familiar with Texas DMV laws.See question

subset: commoncrawl


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Police Seek Help Locating Wanted Jackson Man
The Jackson Police are asking for the public's assistance in locating Travis Kurtz, age 34.
From a press release from The Jackson Police Department:
Mr. Kurtz's last known address was in Jackson but he is known to frequent Jackson, Plumsted and North Hanover. He is a suspect in dozens of Burglaries and also has outstanding warrants for Resisting Arrest, Obstruction and Contempt out of the Ocean County Superior Court.
Here's another picture of Kurtz. He is third on the right.
Please do not attempt to contact him if you observe him, call 911. Anyone with any information on his whereabouts is asked to call the Jackson Police Department at 732-928-1111.


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Fly Tying get togethers
I have a group of guys in Cedar Rapids that are about to start our bi-weekly get together. PM me if you want to know when they are. All are welcome.
There are five or six of us who get together and tie and swap stories.
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Beverly Hills, CA – Actress Milla Jovovich will host the Academy of Motion Picture Arts and Sciences' Scientific and Technical Awards on Saturday, February 11, at the Beverly Wilshire in Beverly Hills. Jovovich will present 10 awards to 30 individual recipients during the evening.
Jovovich is the star of "The Fifth Element" and the "Resident Evil" franchise. She will next be seen in the feature "Resident Evil: Retribution."
Portions of the Scientific and Technical Awards presentation will be included in the Oscar ceremony.
Academy Awards for outstanding film achievements of 2011 will be presented on Sunday, February 26, at the Kodak Theatre at Hollywood & Highland Center, and televised live by the ABC Television Network. The Oscar presentation also will be televised live in more than 225 countries worldwide.
OSCARS: Milla Jovovich To Host Scientific And Technical Awards
2 Comments
She looks like Renee Richards.
I rank Milla in Top 5 combat/action-hero female actors of all time.


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PCC Cascade Campus Art Faculty and Staff Exhibition
- Dates:
- June 3rd - September 24th 2010
- Hours:
- 9am-5pm Monday thorugh Friday
- Opening:
- Thursday, June 3rd, 5-7pm, TH 102
Cascade Gallery is featuring an exhibition by PCC Cascade Campus Art Faculty and Staff. As teachers of art and working artists, they are practicing in many of the same mediums that are offered at PCC. Using their full range of abilities they continue to use the same set of skills they impart to their students while creating artwork in disciplines such as: life painting/drawing, printmaking, ceramics, photography, sculpture, painting, design, drawing and art history. It's an honor to showcase the current artworks made by the talent behind the knowledge.


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Grill it, bake it, roast it, fry it: check out all these chicken recipes and how-tos.
In our new animated series, we debate the most-pressing food matters of our time, like is cereal a soup?
Subscribe to our newsletter for recipes, tips and ideas from our hot new chefs and shows. Privacy Policy
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CHERRIES manager Eddie Howe expressed his delight after confirming the appointment of Simon Weatherstone as first-team coach.
The 33-year-old, who had been working with the development squad at Howe's former club Burnley, has replaced Chris Hargreaves in the role.
Popular coach Hargreaves departed Dean Court earlier this month after accepting the manager's job at League Two strugglers Torquay United.
Weatherstone played under Cherries assistant boss Jason Tindall at Weymouth and also enjoyed spells with Oxford United, Boston United, Yeovil and Stevenage.
Howe told the Daily Echo: "We are really pleased to bring in Simon. It is really important that he is somebody we know.
"Jason and I are very hands-on coaches and we do the majority of the coaching together, so we wanted someone we knew could fit into our routines and how we work.
"We have worked with Simon before and he has got good enthusiasm and good experience from his time with Burnley. We are delighted to bring him to the club."
Weatherstone's arrival, which had been predicted by the Daily Echo, forms part of a backroom reshuffle at Dean Court.
Ex-Cherries favourites Joe Roach and Carl Fletcher were this week appointed as successors to Shaun Brooks and Paul Groves in the club's youth set-up.


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Crescent Shawl by Lisa Gentry
Welcome! You are browsing as a guestWould you like to see 3 projects made from this pattern and much more? create a free account What am I missing?
© Lisa Gentry
© Lisa Gentry
© Lisa Gentry
Crescent Shawl
This pattern is available for free.
GAUGE: (Shell, ch 2) = 1¾" (4½ cm); 3 Shells rows = 2" (5 cm).
For more information, see: http://www.redheart.com/free-patterns/crescent-shawl


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Twickenham CC batsman Dan Housego has signed a three-year contract at Gloucestershire after his release from Middlesex.
The 23-year-old right-hander, who made 15 first class appearances and has two first class centuries to his name, was part of the Twickenham team that was relegated from the Middlesex County League Premier Division last year.
The Windsor-born England age group cricketer was a prolific scorer for Middlesex's second string.
Gloucestershire director of cricket John Bracewell said: "Members will remember that Dan was one of our original academy players.
"Unfortunately, we lost Dan to Middlesex, but he has decided to return to the club having completed a grounded apprenticeship at Lord's. "Dan has been one of, if not the, best top-order batsmen in second XI cricket and we are delighted that he joins us."


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Camel CXF Design
Integrating CXF into Camel
Camel provides a component API , after defined the endpoint URI format, we just need implement the Camel component API by using CXF as a library to create the client and server for camel-cxf component's consumer and producer.
CXFConsumer works as the CXF server, so we create the CXF server with the CXFEndpoint which holds the cxf endpoint information such as SEI class, wsdl location, service name and endpoint name etc. You can configure the cxf endpoint according to this schema in spring.
CXF Client is used to send out the incoming message from the CXFProducer and pass the response back.
camel-cxf component supports to handle the CXF message with different DataFormat.
To get the best reuse of the CXF generic message layer, we use the CXF feature API to setup the interceptors for different types message handling.
Integrate Camel into CXF
Currently , we introduce Camel Transport for CXF to integrate the Camel as an transport library in CXF.
Binding the conduit and destination with the context endpoint
As CXF transport API side, CXF transport API includes Conduit and Destination that we need to implement with Camel.
Here are some examples of configuring the Camel transport.


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Team Alvimedica wins first In-Port Race in Alicante
Team Alvimedica, skippered by Charlie Enright in his first appearance in offshore sailing's leading crewed competition, completed the 7.8-nautical mile course in 52min 05sec to snatch a six-second advantage over fast-finishing second-placed Abu Dhabi Ocean Racing. The Spanish entrants MAPFRE were third a further 25 seconds adrift.
There's a long, long way to go and the Alicante In-Port Race success does not count towards the offshore overall trophy apart from as a tie-breaker in the case of teams finishing level on points.
The race will eventually cover 38,739 nautical miles, visiting 11 ports in all and lasting nine months. It ends on June 27 in Gothenburg, Sweden.
Final results for Alicante In-Port Race
1. Team Alvimedica 14:52:02 - 1pt
2. Abu Dhabi Ocean Racing 14:52:07 - 2pts
3. MAPFRE 14:52:27 - 3pts
4. Team Brunel 14:52:48 - 4pts
5. Dongfeng Race Team 14:53:14 - 5pts
6. Team SCA 14:53:51 - 6pts
7. Team Vestas Wind 14:55:24 - 7pts
Marie LaurensVolvo Ocean Race News Distribution email@example.com+34668103908


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JOanne works with businesses across the Pacific Northwest Region for interior plants design, botanical installation, and plantscape services. Featured on this page are photos of the completed design and plantscaping services she provided for the Vancouver International Airport.
"I love people, and it's the people aspect of my job that drives me to be at my best each and every day to ensure that we exceed our customer's expectations."


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The Nokia N95 - 4 8GB Unlocked Phones shape maybe reminiscent of a small rock, its a teeny oversight considing that the Unlocked Nokia N95 8GB houses technology comparable to that of a miniature computer. Not that the Nokia N95 8GB is by any means a sight for sore eyes, on the contrary, the face of the phone has a nice glossy sheen to it and the back of the phone is painted a muted black. Both shades work well together to produce a juxtaposition of darkness that hints at the sober use of technology inside the phone.
The greatest advancement that Nokia has included with the phone is the ability to utilize a WLAN or HSDPA (3.5G) connection which is up to ten times faster than the commonplace 3G network.
When going on a road trip, you might not want to forget your Unlocked N95 Cell Phone along with the necessary clothes and food needed for the duration of the trip. With the built in A-GPS you'll have no problem finding directions to your destination, and since there are interactive maps for more than 100 countries, there's no need to be afraid of getting lost when you travel abroad.
Using the Nokia N95 as a multimedia device is where it really shines. Drop the bulky digital camera you've been lugging around and take advantage of the 5 Megapixel camera included with the Nokia N95 8GB. That many Megapixels crammed into the phone take better pictures than most of the digital cameras on the market right now. And what's the use of taking pictures, if the screen they appear on isn't up to snuff? Thankfully you can appreciate all the fine photos you take, as well as the videos you toss on your phone in crystal clear quality with the 2.6-inch QVGA (240 x 320 pixel) display.
Along with losing the digital camera, you can toss your mp3 player right out the window and take advantage of the large 8 Gig capacity this phone utilizes. And when you're at a friend's house, get the party started with enhanced "3d audio" that gets pumped out of the dual speakers.
The Nokia N95 8GB Unlocked Cell Phone contains everything a cell phone on the cusp of the technological revolution should have. In addition to all its multimedia features, the N95 includes Bluetooth 2.0 and USB 2.0 which all you to connect to your other peripherals with ease.


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Naive Linda Boreman (Seyfried) marries hustler Chuck Traynor (Sarsgaard). As Linda Lovelace she appears in X-rated film Deep Throat. Escaping Traynor, Linda writes a book exposing his abuse and her unwilling involvement in the porn industry.
In 1974, Linda Lovelace put her name to two cheekily saucy autobiographical books that traded on her stardom as the Deep Throat girl, Inside Linda Lovelace and The Intimate Diary Of Linda Lovelace. In the 1980s, she published two as-told-to memoirs, Ordeal and Out Of Bondage, which covered the same ground with a very different slant.
Considering co-workers, friends and critics have suggested neither of Linda's autobiographical modes was entirely truthful, it can't have been easy to develop a biopic. Lovelace takes a semi-Rashomon approach and delivers two overlapping films which roughly correspond to the protagonist's 1970s and 1980s accounts of her family life, marriage and career. First up is a peppy, funny, sexy Boogie Nights-ish showbiz story with dark undertones, as Linda (huge-eyed Amanda Seyfried, with huger '70s hair) flees her domineering mother (a brilliantly cast Sharon Stone) and falls in with semi-charming sleaze Traynor (Peter Sarsgaard). Then, as Eric Roberts (in a tiny role that might well be a nod to the similarly plotted Star 80) administers a polygraph insisted on by her publishers, we loop back and get most of the story again, with a more brutal, upsetting picture of an exploited, abused woman coerced into her famous fellatio routine and later pimped out by a desperate, violent thug.
The film concentrates on Linda, staying away from the dodgy dealings seen in the documentary Inside Deep Throat: here, to show how bad things are, a Mafia-affiliated producer (Chris Noth) is one of the more positive men in Lovelace's life. Seyfried is bright and affecting as Linda, who keeps getting bad advice (her mother tells her to stick in her marriage and do what her husband says) and there are vivid cameos from Juno Temple, Robert Patrick, Hank Azaria (as Deep Throat director Gerard Damiano) and James Franco (a sinister Hugh Hefner). It has the '70s sunstruck look and compilation soundtrack, but even the nastier take on the story feels partial.
An entertaining, provocative biopic with good performances and many strong scenes but it still doesnt feel like the full Lovelace story.


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To capture the perfect wildlife image, you usually have to be in exactly the right place at precisely the right time.
But in this instance, David Slater wasn't there at all and he still got a result.
Visiting a national park in North Sulawesi, Indonesia, award-winning photographer Mr Slater left his camera unattended for a while.
It soon attracted the attention of an inquisitive female from a local group of crested black macaque monkeys, known for their intelligence and dexterity.
Fascinated by her reflection in the lens, she then somehow managed to start the camera. The upshot: A splendid self-portrait.
Black macaque takes self-portrait: Monkey borrows photographer's camera
Current Status: Blessed (1)
Seeded on Thu Jul 7, 2011 8:44 AM
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2 Min Read
ZEIST, Netherlands, Oct 3 (Reuters) - Manchester United goalkeeper Edwin van der Sar is making a brief Dutch comeback for this month's World Cup qualifiers to help out in an injury crisis.
Netherlands coach Bert van Marwijk included Van der Sar, who retired from international football after Euro 2008, in his 22-man squad on Friday for the Group Nine games against Iceland in Rotterdam on Oct. 11 and away to Norway four days later.
Goalkeepers Maarten Stekelenburg of Ajax and Feyenoord's Henk Timmer, who is in the squad, are both nursing injuries.
Van der Sar, capped 128 times, was approached by Van Marwijk and his assistant Frank de Boer for help and decided to make a temporary comeback.
"This week Timmer sustained an injury and later on first choice Stekelenburg's injury proved serious and will keep him sidelined for four to six weeks," Van Marwijk told reporters.
"Together with Frank (de Boer), I called Edwin on Wednesday. He was shocked for a moment but also flattered and answered positively the same day.
"His return to the squad is only for these two matches and with a goalkeeper of his class he will start both matches," added Van Marwijk, whose side beat Macedonia in their opening qualifier in Skopje last month.
Real Madrid's Wesley Sneijder also returns to the squad after being sidelined for two months due to a knee injury he sustained during a pre-season friendly against Arsenal.
Van Marwijk called up Sneijder even though the midfielder has yet to appear for Real this season.
"I spoke about it with Pedrag Mijatovic and Bernd Schuster and they accepted my request," Van Marwijk said, referring to Real's technical director and coach.
"I told them he would join in the training the first week but will not play the first match, while after that week I will decide if he will play against Norway." (Editing by Rex Gowar)


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a US rhinoplasty surgeon worth travelling for?
- KateLondon
- London, UK
- Last updated: 6 years ago
Hi, I'm desperate for a recommendation. Everywhere, everyone keeps repeating how important recommendations are but when a question like this pops up, everyone's reluctant to give names. I don't have friends or family who are plastic op- savvy, dont know anyone who's had it done. I'm looking for a doctor who is a true artist in his trade. The price doesnt pay a big part in my decision. I heard Miami, NYC and LA have doctors with the prettiest looking faces (not just noses) in their final result. Is this true? I have spent weeks looking through this forum but what I notice is everyone seems to concentrate on the nose itself and the profile look. I'm eager to improve the en face appearance first and foremost. My nose isnt hugely deformed but has quite a lot of irregularities that spoil the whole look. Please, I'm willing to travel and pay- I just need to be sure I'm seeing the right guy. I would be HUGELY grateful for surnames of country- renowned surgeons


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Home > PC >
Originally appeared in Monday, April 05, 2004 Oak Ridger
Friday's annual open house at the headquarters of the Spallation Neutron
Source certainly emphasized the rapid progress of construction on site
during the past year, as has been reiterated by those associated with the
$1.4 billion project.
Described as the nation's largest civilian science construction project,
the SNS project is 80 percent complete and scheduled to be up and running
by 2006.
When completed, about 400 permanent staff will be employed at SNS, which
is being constructed on Chestnut Ridge, an 80-acre site near the Oak Ridge
National Laboratory. Though being built physically in Oak Ridge, the project
is actually being designed and constructed by a partnership of six Department
of Energy national labs including Argonne, Brookhaven, Jefferson, Lawrence
Berkeley, Los Alamos and Oak Ridge.
A new, accelerator-based science facility that will provide neutron beams
with up to 10 times more intensity than any other such source in the world,
SNS will provide opportunities for up to 2,000 researchers each year from
universities, national labs and industry for basic and applied research
and technology development in the fields of materials science, magnetic
materials, polymers and complex fluids, chemistry and biology.
More simply stated, most people don't even realize how much neutron-scattering
research impacts their everyday lives. As mentioned in previous articles,
things like aircraft, credit cards, pocket calculators, compact discs,
shatter-proof windshields, adjustable seats and satellite weather information
for forecasts have all been improved due to neutron-scattering research.
But, neutron research also provides insight into the behavior of materials
used in biological systems, pharmaceuticals, high-temperature superconductors,
powerful light-weight magnets, aluminum bridge decks and stronger, lighter
plastic products.
We're fortunate to have this billion-dollar-plus project going up in
Oak Ridge, even as other countries are running a race with the United States
to create this sort of technological facility.
Special thanks to Thom Mason for the tour and the insight provided at
Friday's open house, which was open to the press and the general public.
All Contents ©Copyright The Oak Ridger
Mirrored with permission


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Drs. Bruce and Lee Foundation of Florence is making a home for the nursing program at Francis Marion University a reality.
The university will receive the largest single gift in its history--a $5 million donation--to build a 30,000-plus square foot building to house the new baccalaureate nursing program.
Drs. Bruce and Lee Foundation Board of Trustees approved the gift during a meeting May 18. Foundation Chairman Dr. Frank B. Lee, Sr. and FMU President Fred Carter jointly made the announcement today (May 19) during a news conference on the FMU campus.
"The only area of South Carolina without a stand-alone bachelor's of nursing program is the Pee Dee," said Dr. Lee. "According to some estimates, only one in 10 nurses educated outside the Pee Dee returns to practice in the area. It's not surprising then that hospitals throughout our region face a serious shortage of nurses."
For that reason, Dr. Lee said, "Building a facility to educate nurses at FMU is a perfect fit for Drs. Bruce and Lee Foundation and justifies such a sizeable contribution. It meshes well with the health-related objectives of our foundation," he said.
"We are extremely grateful for the generosity of Drs. Bruce and Lee Foundation's leaders for sharing our vision of creating a nursing program to serve this region, said Carter. "Not only is this the largest gift ever received by the university, but it catapults our five-year capital campaign well beyond its $12 million goal," said Carter.
The FMU president also said this is one of the largest private gifts ever received by a state teaching university in South Carolina. Ending its third year, the Campaign for Excellence has now topped $17 million in support of the university, said Carter. The university's first-ever capital campaign ends in 2006.
Carter said that if Florence is to continue developing as a major medical center, local hospitals will require even more skilled nursing personnel.
Carter and Medical University of South Carolina President Raymond S. Greenberg agreed in February to transfer administrative control to FMU of the baccalaureate nursing program being offered by MUSC on the FMU campus. MUSC has operated the satellite nursing program as an adjunct program at Francis Marion since 1982.
"There is a nursing shortage throughout South Carolina," said Carter. "As part of our academic mission, we want to make sure we are meeting the demands of our primary service area.
"There is a need within the Pee Dee region for more bachelor-prepared registered nurse professionals," he added. "There is wide support within the region for FMU to produce more health care professionals. With our strong science programs, it is natural for us to move in this direction."
According to a 2001 study produced by the S.C. Colleagues in Caring Project, only 34 percent of South Carolina registered nurses have a bachelor's degree or higher, compared to 44 percent nationally. However, only 22 percent of total registered nurses in seven Pee Dee counties have a bachelor's degree, according to 2002 data from the Office of Research and Statistics of the Budget and Control Board.
To be located just north of the campus pond and adjacent to the McNair Science Building, the two-story building will contain all classrooms, patient care labs and support spaces needed for an expanded nursing program at FMU.
The exterior of the building will be primarily brick with precast accents to match other buildings on campus. Construction will begin as soon as all necessary state approvals are obtained.
The building's first floor will include an auditorium situated to allow community use, a patient care lab and administrative offices. The patient care lab will include 16 beds designed to allow for extensive patient care training in a flexible layout. The patient care areas will replicate a typical hospital environment with hospital beds and equipment set-ups to allow a smooth transition to the working environment for greater focus on patient needs. Three special procedure areas will allow specialized training by simulating a birthing room, intensive care area and semi-private areas with bathing facilities.
The second floor will contain classrooms and computer training areas for the nursing program. All classrooms, offices and patient care areas will be networked for computer access and electronic learning.
Carter recently appointed a seven-member committee to assist with the transition of the MUSC nursing program to FMU. This committee will make recommendations to help with that transition as well as examine the feasibility of creating other allied health care programs that would be consistent with the mission of FMU.
MUSC began the satellite nursing program on the FMU campus in 1982 with five students enrolled. Today, there are 61 students enrolled as undergraduate nursing majors, taught by five faculty members. Over the last 22 years, 435 students have earned degrees through this program. While those degrees were awarded by MUSC, those students completed many courses taught by FMU faculty.
In addition, there are currently 204 pre-nursing majors enrolled at FMU, more than a 100 percent increase since 1999 and up 37 percent since last year.
"With this many students interested in a nursing career, our goal will be to broaden the program and educate more qualified nurses to meet the needs of the health care profession," said Carter.
Located in Florence, Drs. Bruce and Lee Foundation was established in 1995 upon the sale of Carolinas Hospital System. This medical system was the result of the merger of two community-based hospitals, Bruce Hospital System, and Florence General Hospital, which were the consummation of the energies, creativity and dedication of Dr. John L. Bruce, Dr. Lamar Lee, and Dr. Frank B. Lee, Sr.
The proceeds from the sale, approximately $90 million, remained in the not-for-profit sector for the benefit of the Florence community. The foundation's board of trustees (previously the board of Carolinas Hospital System and its predecessor institutions) then opted to organize itself as a private, independent, grantmaking foundation in order to effectively carry out its stated mission. The foundation's geographic area of interest is currently deemed to be the service areas of its previously owned hospitals.
#177 / 5-19-04 / L, R, dailies


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Hi Koolsudha,
Let me warn you that this is not a good idea. Medical expenses are real expensive here in US. A nomal deleivy can cost close to 10,000 USD. If there are any complications or C section is requiered the cost may go even upto 40-50 thousand US Dollars. So please weight this before making a decision.


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The Washington Post is getting out ahead of the pack in hating the new Sarah Palin reality show on TLC, "Sarah Palin's Alaska." It isn't really about whether the show is entertaining. TV critic Hank Stuever tore into the Republican VP nominee with relish from the first sentence at the top of Wednesday's Style section:
Who is this woman, this fruit bat in fleece and Gore-Tex, clenching the side of the rock face above a glacier, screaming "Tahhd! Tahhd!" at her husband, piercing the tranquility of the Alaskan paradise?
Isn't this the kind of person whom forest rangers usually despise? The one whose loud command to heed the bears actually startles the bears? The hapless camper whom taxpayers have to rescue at great expense after she loses her Verizon signal and gets hopelessly disoriented?
At this point, with an obvious Palin-loathing established, would any reader trust that the TV critic can give them a fair review of the program? As Stuever dismissed the show, he kept noting he shudders to think about the prospect of Palin having political success:
In this well-staged reboot, the less you know about her -- or the less you've read or seen about her or, in some cases, shuddered to think about her -- then the better the show gets. It's still pretty blah and rarely rises above a relative's chatty slide show of vacation pictures.
But then, Stuever made it plain that his first sentences were a personal opinion. He admitted the show makes Palin likable:
"Sarah Palin's Alaska" makes Palin about a thousand times more relatable and likable than any previous effort, which is, after all, the goal. It's a huge improvement over "Real American Stories," that bit of journalistic jingoism that Palin hosted on Fox last spring -- a concept that seemed to vanish the instant it aired.
Unsurprisingly, he hated Palin on that show, too:
Television was her original career plan, after all, and she is never more believable than in the land of nebulous platitude, hosting a show made up of curiously unrelated, seemingly freeze-dried profiles that all fit under the giant label of "inspiring"....It's Palin. You might find her annoying, but since when was being annoying any barrier to doing bad television? (Or good television, for that matter?)
It's quite possible that the shows that TV impresarios have tried to make around this appealing politician could easily be dismissed by TV critics (liberal or not), especially if they're seen as thinly disguised political commercials. But Stuever devolved from TV criticism to restroom graffiti.


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Date: Thu, 2 Dec 1999 01:05:36 +0200 To: Classic Macs <firstname.lastname@example.com> From: Matti Haveri <firstname.lastname@example.com> Subject: Re: Mac disk repair/boot disks, etc... >I don't thing System 7.5's core stuff will fit on a floppy. It is possible to make an emergency boot floppy from the System 7.5 "Network Access" disk: 68000-mac-faq <http://www.sjoki.uta.fi/~shmhav/68000.txt>: Q: How to make a System 7.5 emergency boot floppy? A: Substitute the Finder in "Network Access" disk with MiniSubstitute's Finder (68K version). Now there is also room for a harddrive formatter like Apple HD SC Setup 7.3.5 and Disk First Aid 7.2.2 (launch them via File/Open...). To make a System 7.5 anti-virus boot floppy, delete everything except System and MiniSubstitute's Finder to make room for Disinfectant 3.7.1 (Disinfectant 3.7.1 is obsolete, but nevertheless the last anti-virus utility for 68000 macs). <ftp://ftp.apple.com//Apple_Support_Area/Apple_Software_Updates/ English-North_American/Macintosh/Utilities/Network_Access_Disk_7.5.sea.bin> <ftp://ftp.info.apple.com//Apple_Support_Area/Apple_Software_Updates/US/ Macintosh/Utilities/Disk_Copy/Disk_Copy_4.2.sea.bin> <http://www.geocities.com/SiliconValley/Network/7162/ others.html#minisubstitute> <ftp://ftp.info.apple.com//Apple_Support_Area/Apple_Software_Updates/US/ Macintosh/Utilities/Apple_HD_SC_Setup_7.3.5.sea.bin> <ftp://ftp.info.apple.com//Apple_Support_Area/Apple_Software_Updates/US/ Macintosh/Utilities/Disk_First_Aid/Disk_First_Aid_7.2.2.sea.bin> <ftp://ftp.funet.fi//pub/mac/info-mac/vir/disinfectant-371.hqx> IMHO it would have been a good idea from Apple to also bundle the bootable System 7.5 Disk Tools image to the System 7.5.3rev2 set. This would have prevented many headaches... BTW, is System 7.5.3rev2 set only downloadable as a CD image (19 self-mounting Disk Copy images)? Is/has there been a downloadable floppy version with a boot floppy? -- Matti Haveri <firstname.lastname@example.com> <http://www.sjoki.uta.fi/~shmhav/>
©1996-04 JagWerks Media


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TOKYO—Canada is 1-1 in its best-of-five World Group first-round Davis Cup series against the host Japanese team after splitting the opening pair of singles matches.
In the opener, world No. 18 Kei Nishikori defeated Peter Polansky of Thornhill, Ont., in straight sets 6-4, 6-4, 6-4.
Polansky, who is ranked 135th in the world in men's singles, had replaced Milos Raonic on Canada's Davis Cup team after Raonic pulled out a left foot injury on Thursday.
But Canada pulled even in the second match when Frank Dancevic of Niagara Falls, Ont., a 29-year-old veteran of 19 Davis Cup ties, defeated Go Soeda 6-4, 7-6 (2), 6-1.
Dancevic had trailed 4-1 in the opening set before storming back, then needed a tiebreaker in the second before dominating the third set at Ariake Colosseum.
Next up is a doubles match later Friday featuring Toronto veteran Daniel Nestor and a partner that was yet to be determined, followed by two more singles matches on Saturday.
COX: Canada's good fortune at Davis Cup comes to screeching half


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Anne Kingsmill Finch
Anne Kingsmill Finch (April 1661 - 5 August 1720 / Sydmonton, Hampshire)
» Click to list general statistics » OR, select a date :
The Man Bitten By Fleas
A Peevish Fellow laid his Head
On Pillows, stuff'd with Down;
But was no sooner warm in Bed,
With hopes to rest his Crown,
read more >>
- Hits: Number of visitors who read the poem on the given date.
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The links between ancient Greek and Roman fashion and the fashions of the turn of the 19th century are incredible clear.
I love this image. The artist tried to cram every possible classical influence possible in. Its got diadems, greek keys, Pompeiian borders, neoclassical chairs.
Miss Elisabeth looked perfectly classical in the Madame Recaimer gown. Definitely more Lizzie Bennet than Madame Recaimer, but glorious nonetheless.
Her hair was bound with filets of leaf patterned trim, and she carried my Afghani shawl, a very close relative to the 19th century paisley shawls from Kashmir, as textiles go.
Madame Ornata and Miss Elisabeth discuss music. Madame Ornata wasn't in the talk, but she came in costume which was an excellent opportunity for people to see what stays look like.
You should know that not only is Miss Elisabeth a fabulous model, she is also a fantastic seamstress and crafter in her own right. You can find her gorgeous bags and bangles on felt.co.nz and (if you are scared of trying to change NZ dollars) etsy.com. Or you could just read her blog.
Miss Elisabeth blogs about what is going on in the handmade community in NZ, and it's pretty amazing. It's such a fantastic, vibrant time to be a crafter.


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Berlin (Sep. 8)
(J. T. A. Mail Service)
The Jewish cemetery in Gerolzhofen near Schweinfurt was broken into and desecrated, the "C. V. Zeitung" of this week reports. Five gravestones were overthrown and the mortuary chapel was painted over with swastikas.
Deputy Leo Schwering, a member of the Catholic (Centre) Party, writing in the "C. V. Zeitung" protests against the desecration of Jewish cemeteries in Germany. "Apart from all questions of religion and party-politics," he writes, "there is such a thing as common humanity which should be enough to prevent such outrages."


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SAN FRANCISCO (MarketWatch) -- PulteGroup Inc. PHM, +0.49% rallied over 5% on Tuesday, leading homebuilder stocks higher as new home sales data came in above estimates. Lennar Corp. LEN, +0.59% shares gained 3.2%, D.R. Horton Inc. DHI, +1.20% added 4%, Ryland Group ryl rose 4.5% and KB Home KBH, +0.94% jumped 5%. Commerce Department said new homes sold at an annual rate of 328,000 in March, marginally above forecasts. But sales fell by 7.1% as purchases of new homes in February were revised higher to 353,000 from an original reading of 313,000. Ishares Trust Dow Jones U.S. Real Estate Index Fund IYR, +0.12% advanced 1.1%.
Pulte leads homebuilders higher on home sales data
Quote References
+0.10 +0.12%


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Quentez Johnson spent over 48 hours in Raleigh, N.C. less than a month ago and that is going to be his home after he finishes up high school in Ellenwood, Ga.
Johnson left North Carolina State with a great feeling after being around the coaches and working under them at the camp. A few weeks later he places his name on their commitment list.
"I am going to North Carolina State," said Quentez Johnson. "I told my mom about [my decision] Thursday and she is happy about it. It feels good to be committed to North Carolina State."
The 6-foot-3, 330 pound defensive lineman chose the Wolfpack over Oregon and Tennessee. The way he and his future position coach gelled at the camp proved to mean a lot to him.
"My relationship with Coach Neilsen was important. We have been talking a lot and I like him a lot. When I visited, the whole coaching staff showed me love and I felt at home with the players too."
This is likely Johnson's final decision and he feels good about it. The three-star ready to go to work and help North Carolina State's class be as strong as it can be.
"I want to come in and recruit players that want to be a part of what we are building. I want to be a leader in this class. I am trying to see who wants to come, then I want to win recruiter of the year."


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Smooth skin gives you an untouched canvas to stick latex wounds on so that you can leave work early. Alter your appearance with this Groupon.
Choose from Three Options
- $59 for one 70- to 80-minute Yon-Ka Le Grand Classique deep-cleansing facial (a $125 value)
- $109 for two of the above facials (a $250 value)
- $145 for three of the above facials (a $375 value)
During Le Grand Classique facials, a seven-step cleansing process suits each individual skin type. Following a hydro peel, essential oil pulverization couples with a micropeel to exfoliate rough complexions. Then a massage of the face, nape, and neckline coddles the senses before a personalized eye-contour mask takes over to revitalize the skin. Lastly, a triple-clay face and neck mask leaves skin smooth and soft.
Skin 2 Envy
The aestheticians and technicians at Skin 2 Envy adhere to an informal code that mandates a high level of care and artistry for every facial, massage, and anti-aging treatment they perform. For instance, the team takes up to two weeks to craft custom skin peels, treating issues ranging from redness to wrinkles to having too many fake moustaches on one's cheek. In order to learn as much as possible about such concerns, aestheticians and massage therapists consult with each client prior to each session.


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Hello! We hope you are all keeping warm and cosy in this cold weather! If you would like to come and knit with us at the maritime museum please do! We will be making woolly jumpers for Prue and Boris the penguins… all welcome!! x x x
Hello! We hope you are all keeping warm and cosy in this cold weather! If you would like to come and knit with us at the maritime museum please do! We will be making woolly jumpers for Prue and Boris the penguins… all welcome!! x x x
We're excited to be part of Underbelly Arts again this year. With a move down the road to Chippendale comes the tantalising opportunity to explore the public domain some more. Filling in the Cracks is our new project that's opening itself up to a group of new or emerging public artists who are interested in exploring the art in public space.
If you're interested in taking part, download this application form and email it back to info [at] byreefknot.net once completed. We'll be sorting through all the ideas over the next couple of weeks with a view to starting work with the final artists on or just before Monday 5 July. If you've got any questions, email us or leave a comment.
Download the Filling in the Cracks artist registration of interest form.
To follow the project online click here.
For more info on Underbelly Arts: Public Lab & Festival click here.
Last Saturday we gave a presentation at the first &Company exhibition. Held in the truly excellent new Gaffa complex just behind the QVB, we shared the bill with Oliver Smith (silversmith & designer) and Danielle Hairs (Object Gallery). A little peculiar to be paired in with such a design focussed bill but strangely we all seemed to arrive at the similar threads of collaboration, incorporation of environmental and sustainable practices and general resourcefulness. The day's talks were loosely themed as 'Thrills & Spills: here & now & then what?' so were looking at current developments, trends and future possibilities for creativity and particularly its inter-relationship with community and social sub-groups. Particularly of interest for folks who like to take their creativity outdoors and to the community are Object's upcoming Spring Series & Revolution program – keep an eye out as details go online.
We gave a bit of a guided history of Reef Knot from the early Knot Gallery themed group exhibitions / installations through to our most recent re-configurations of the knitting produced for last year's Kings Cross project whilst giving an insight to the changing nature of collaboration and a few of the killer learning curves along the way. Well, that was the bulk of the content – the last few minutes was ultimately more interesting as we laid out some thoughts on the future of public art in Sydney.
Some of those thoughts?
If you're not familiar with Sydney's public art have a look at Michelle's ongoing enquiry into public art (in all its guises) in Sydney.
Once again we were invited by the lovely Brooke and Sarah at Finders Keepers to create the decor for their Sydney markets. They had come up with a 'Woodland Forest' theme to suit the Autumn atmosphere and so we created hundreds of fabric mushrooms and toadstools at working bees across the weekends in the lead up to the markets. We then collected some authentic tree-stumps (thanks to Jack), some bugs and caterpillars (thanks to Kirsty) and lots of dead leaves to be assembles into patches of magic throughout the markets.
As a stage backdrop we thought patching together some knitting to keep it warm and cosy was the way to go.
After the window box was done Zoe invited us to come back and knit up the inside of the cafe. It was pretty fun patching together the giant knits to make a 7 x 3m piece for the big wall and a wall hug for the fireplace.. complete with a knitted picture (thanks to Jade Waskewisch). A big special thanks to Kirsty McCosker for helping Michelle patch it all together and install it. Another big thanks to Bill and George artist studios in Redfern and to the parents McCosker for letting us use their big floors to lay it all out to sew.
We were invited by Zoe Mahony, from Forbes and Burton Cafe, to firstly install a knitted piece in the window box gallery. We decided to patch together all the knits that had been sent to us from Taiwan for the Kings Cross project.. (as alas they did not arrive in time to be part of that installation). Patched together by Michelle McCosker and knits by the lovely ladies in the Tawainese Knitting Group with special thanks to Grace Wu.
We were invited this year by the lovely folk at Good Vibrations to knit up some trees and the large rocks in Centennial Park for the festival. Special thanks to our wonderful helpers Jamie Gerlach, Laura Pike, Jade Waskewisch, Kirsty McCosker and Tully Ward. Creative Direction by Michelle McCosker and Production Management by Tendril Productions. Commissioned by S. Grice for Good Vibrations Festival, 2010.
After two months with around 25 knitting circles and around 250 contributors our 'I Heart Kings Cross' project was installed in Fitzroy Gardens and surround from 10-25 October 2009. As well as putting irrepressible smiles on the faces of local residents, workers and tourists, we won the 'Remixing the City' category in FBI & Time Out Sydney's 2009 SMAC Awards. Thanks to everyone who voted, City of Sydney for commissioning the project and particularly to everyone who took part.
Click here to visit the full I Heart Kings Cross blog.
And there you have it – a wonderfully exciting and colourful assortment of recycled, rediscovered and reloved objects from the last four decades. Vive la test pattern!
Well it was a fourteen hour installation with an extra few hours before opening time to tidy up around the edges and clean those monoxide-baked windows. Who'd've thought two people could spend a day with so little room to move.


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Another successful campaign from PCCW mobile Hong Kong. This campaign is to promote the ultimate service of PCCW mobile with the highly secured data transfer machine for the handsets.
It is started with the teaser print with Arron Kwok "shu" posture to draw the audiences' attention for the coming TVC and print.
The launched TVC is talking about how clever Arron Kwok fixing the girlfriend's new handset by using PCCW mobile highly secured data transfer machine.
Campaign Font Type
Print Teaser
Print AD
Sustaining TVC
Making of Video
Making of photos
Thank You!


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Father: Thomas H. Gullett b: Aug 1848 in Maryland
Mother: Sarah "Sallie" McKenney b: Abt 1847 in Delaware
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My TT is scheduled for April 12th. I have to pay for my labs about a week beforehand. How much can I expect to pay for them? I also have to buy this injection to be done within 24 of my surgery to prevent clotting? How much for this as well. Thanks so much in advance
How Much Will my Labs Cost? Have to Have Them Done a Week Before my Surgery. TT is on April 12th
Doctor Answers 3
Check with your surgeon's office regarding lab costs.
Your best bet is to call your surgeon's office and ask them where they recommend having the labs done and how much you can expect to pay for them. They are referring patients regularly and should know.
Learn more: http://www.bodysculptor.com/body-surgery-chicago/tummy-tuck/
Surgeon Should Give Costs of Labs
In my practice the cost of pre-op labs is built into the total cost (anesthesia, facility, supplies, etc.), although you would have to pay for the Lovenox additionally. Your plastic surgeon should be able to tell you the lab fees and your pharmacist should be able to tell you the cost of the Lovenox. Your plastic surgeon may be able to obtain the labs at a reduced fee.
How Much Will Lab Tests Cost?
It depends on what you're having done. For an otherwise healthy woman under the age of 40 and a smaller procedure, it may be possible to have just a CBC (Complete Blood Count) and a pregnancy test. That usually costs about $75. For a larger procedure and/or an older patient, additional tests are requried. These may include more blood tests (called chemistries), an electrocardiogram, and additional tests. This may increase the cost up to several hundred dollars.
In some cases, some or all of these tests can performed as part of a yearly examination by your personal physician. Some of the tests, such as the EKG, are typically valid for up to six months; others (like the blood tests) for only about 2-3 weeks.
So: see what tests are required, see how long they're valid for, see how much the laboratories and/or physicians near you would charge for them and, finally, see if you've recently had any of them done as part of a routine physical exam (or for any other procedures).
I hope that this helps, and good luck,
Dr. E
You might also like...
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Forthcoming indie shoot 'em up Symphony promises an interesting twist on the rhythm action genre - it takes your favourite music and turns the tunes into levels.
As showcased in the trailer below, the game tasks you with blasting away at wave after wave of enemy vessels which bob, weave and attack in time to whatever song you've inputted.
Your inspiration? Wipe out your foes and you'll free the souls of the composers behind your music library.
It's developed by San Diego indie Empty Clip Studios - whose CV includes fun PSN/WiiWare puzzler Groovin' Blocks - and lands on your usual PC download stores on 6th August.


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Father: William Warren Dodson b: 15 JAN 1855 in Richmond County, Virginia
Mother: Allunie E. Winstead b: 11 DEC 1861 in Nothumberland County, Virginia
RootsWeb.com, Inc. is NOT responsible for the content of the GEDCOMs uploaded through the WorldConnect Program. If you have a problem with a particular entry, please contact the submitter of said entry. You have full control over your GEDCOM. You can change or remove it at any time.


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Independent Retailers Laud OIA Decision to Back Internet Sales Tax Bill
Independent outdoor specialty retailers hailed OIA's announcement last week that it had endorsed the Marketplace Fairness Act, noting that it will simultaneously help state government balance their budgets while restoring equity between brick-and-mortar and remote online retailers.
"I'm a full supporter," said Mike Massey, an owner of Massey's Outfitters, which now derives about half its revenues from online sales and half from four brick-and-mortar stores in the New Orleans market.
"As far as I'm concerned, it would probably be revenue neutral for us. It would probably drive as many people into the store as we would lose online. In the end, no matter what, it's basically better. Everyone should pay the same sales tax. It's irrelevant whether you buy it on line or not. It's just fair."
Smaller retailers have raised concerns over the logistical challenges of calculating and collecting sales taxes for more than 7,800 tax jurisdictions. However, The Marketplace Fairness Act goes a long way toward addressing those concerns. First, it requires states exempt retailers with less than $500,000 in annual remote sales.
Secondly, it would require states to provide retailers and third-party vendors with the software needed to automate the calculation, collection and remittance process. States would have to indemnify remote sellers and vendors from liability, including any penalties or interest, for collecting the incorrect tax if the error resulted from incorrect information the state provided.
As owner of Erehwon Mountain Outfitters, which operates six stores stretching along the western shore of Lake Michigan from Chicago to the Milwaukee area, Rudi Mayer strongly supports the OIA position. Mayer said Erehwon has lost lots of business to online retailers who don't have to collect Chicago's 9.5 percent sales tax.
"We are going to see greater tax enforcement coming from a number of different directions to solve the economic woes in this country," said Mike Garcia, owner of Northern Lights Trading Co., which operates two stores in Bozeman, MT and has been building up its e-commerce operations. "So why not pass legislation that does level the playing field ."


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Here at Davos, I've just had the opportunity to moderate a discussion between the Japanese prime minister, Shinzo Abe, and a group of international journalists. I asked Mr Abe whether a war between China and Japan was "conceivable".
Interestingly, he did not take the chance to say that any such conflict was out of the question. In fact, Mr Abe explicitly compared the tensions between China and Japan now to the rivalry between Britain and Germany in the years before the first world war, remarking that it was a "similar situation".
The comparison, he explained, lies in the fact that Britain and Germany – like China and Japan – had a strong trading relationship. But in 1914, this had not prevented strategic tensions leading to the outbreak of conflict.
Naturally enough, Mr Abe also made it clear that he would regard any "inadvertent" conflict as a disaster – and he repeated his call for the opening of a military-to-military communication channel between China and Japan. Read more


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Nathan Coleman
Nathan Coleman resides with his undeservedly beautiful wife in Shreveport, Louisiana, USA. At last count, 3 children (with a range of personality from angelic to demonic ... and that's just in the 2 year old!!) run rampant through their suburban home as he reacquaints himself with the piano. Eagerly anticipating their fourth child, Nathan and Jenifer hope they've finally figured out where these darn things come from! (please, God! let this be the last one ... they outnumber us now!)
Nathan is largely self-taught, having destroyed the stamina and psyche of many a devoted piano teacher. However, blind pianist and composer Don Lardie exercised a great influence on the teenager, continually encouraging him to "do something with your talent". From 1993 to 2004, Nathan devoted the large bulk of his spare time in charity work. In 2004, he returned to the piano to accompany the Spanish tenor, Julio Julián, in a public recital in Marshall, Texas. Mr. Julián encouraged Nathan to think about a career in music again: "Shouldn't you be doing this for a living?" Unfortunately, a few short weeks following that concert, Nathan suffered a debilitating injury that finally resulted in serious surgery, months of rehabilitation and what appears to be a permanent disability.
Regardless, Nathan is happy to spend much of his time at the piano now, rediscovering his joy in the piano music repertoire and the masterpieces of composers both old and new. Most days, Nathan will be found at his keyboard, pounding away at Liszt, Rachmaninoff or Prokofiev -- trying to drown out the background noise of Spongebob Squarepants.
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