text:
Germany information
- General information
- Official addresses
- Education system facts
- Learning German
- Exchange programmes
- Germany for young people
Germany for young people
- Youth work and youth policy in Germany and Europe
- Work & life in Germany
- Current topics
Current topics
- September 15: International Day of Democracy
- In Focus: Cultural Education in Germany
- Environmental education/sustainability in Germany
- European Day of Languages - Perspectives on Multilingualism
- Refugees in Germany: Focus on Education
- Immigration Policy Germany
- German literature and searching for literature in Germany
Research promotion and funding in Germany
Bundesministerium für Bildung und Forschung (BMBF) / Federal Ministry of Education and Research
The Federal Ministry of Education and Research (BMBF) is the political body in charge of vocational and higher education and training and research. It is organised into eight departments. The Central Services department is in charge of human resources, budget controlling, including grant awarding proceedings, and information technology in the BMBF. The seven other departments [...]
Funding your research in Germany (2017 publication)
The brochure explains German research funding policy programmes and the underlying rationale. Target group: international graduate and postgraduate students, researchers.
Research in Germany: Land of ideas (interdisciplinary portal)
The web portal is a joint venture of the German Ministry of Education and Research (BMBF) and partners in industry, it addresses researchers and students from abroad. Germany is presented as a country with a tradition in research and invention, and its current role as a leading figure in terms of invention and innovative research is emphasised. International researchers are [...]
Dokument von: Bundesministerium für Bildung und Forschung (BMBF)
Strengthening Germany`s role in the global knowledge society: Strategy of the Federal government for the Internationalization of Science and Research
The English language summary of the strategy paper, which was presented on behalf of the government in February 2008, outlines the challenges and opportunities Germany faces in the light of globalisation, and its future strategy regarding collaboration and competition in research and science. Focus is placed on excellence, innovation and the mobility of high potentials [...]
FAQs: Preparing a successful research stay in Germany
The brochure provides some practical tips and information to help researchers prepare for a research stay in Germany. However, because the landscape is developing so
dynamically, the brochure can make no claim to be complete but it offers links to websites where you can find the latest information on visa regulations, health insurance questions, the various kinds of research [...]
Dokument von: Bundesministerium für Bildung und Forschung (BMBF)
The German doctorate − A guide for doctoral candidates (2015)
This booklet for (prospective) international doctoral students shows the different options for doing a doctorate in Germany. It explains the formal requirements, gives some practical advice on finding the right supervisor or doctoral programme. It also presents sponsoring and funding options.
Research careers in Germany a guide for international postdocs and experienced researchers (2016)
This brochure outlines the career opportunities Germany offers international postdocs and experienced researchers. It also contains some practical advice about visas, insurance and living in Germany.
Funding Advisory Service by the Federal Ministry of Education and Research
This website is provided by the Federal Ministry of Education, and Research in Germany. It offers information on research funding programmes by the federal states, the government, private foundations, and the European Union. A ´´News´´ section provides current information and time schedules.
Dokument von: Bundesministerium für Bildung und Forschung (BMBF)
BMBF Programme for the Promotion of Empirical Educational Research
This portal provides information on the Framework Programme for Empirical Educational Research, launched by the Federal Ministry of Education and Research in November 2007. Research priorities within the Framework Programme are introduced and users will find details regarding current projects, calls, funding directives. In particular, the portal provides information for young [...]
Dokument von: Bundesministerium für Bildung und Forschung (BMBF)
EURAXESS Germany - Germany for Researchers
EURAXESS Germany is the National Coordination Point at the Alexander von Humboldt Foundation, an information and advice point for internationally mobile researchers wishing to come to Germany or go abroad to work in research. On this website you can find information on funding opportunities, job offers, social security and tax issues and other topics relating to researcher [...]
Germany Thinks - the German research landscape
The Goethe Institute dossier on social sciences and research portraits individual institutions and researchers in the area of (applied) social sciences, and an alphabetical list of research centres in Germany. Furthermore, links to various subdisciplines can be activated (religion, law, philosophy, urban development).
Germany Thinks: Research Centres A-Z
An alphabetically sorted list of research institutions in Germany with a focus on social and cultural sciences. A short description of the institutes can be activated, including key words, and links to the website.
Research funding for international applicants (to Germany)
The European dimension of research promotion
Euraxess: Researchers in Motion
The European Researcher`s Mobility Portal is a joint initiative of the European Commission and the 33 countries participating in the European Unions Sixth Framework Programme for Research. The Portal offers a more favourable environment for career development opportunities for researchers in the European Research Area by providing the necessary structured information as [...]
Green Paper European Research Area: New Perspectives
The Green Paper, which was adopted by the European Commission on April 4, 2007, launches a debate on the developments in the European Research Area, as defined by the EU Council in the Lisbon Strategy in 2000. As developing countries such as China and India are making rapid progress in research and development, the Green Paper states the need for mobility in research in the [...]
Conditions of Entry and Residence of Third Country Highly-Skilled Workers in the EU (European Migration Network)
This EMN Synthesis Report aims to summarise and compare, within a European perspective, the findings from eleven National Contact Points (Austria, Belgium, Estonia, Germany, Greece, Ireland, Italy, Latvia, Sweden, The Netherlands and the United Kingdom) of the European Migration Network (EMN), on the conditions of entry and residence of third country highly-skilled workers in [...]


text:
Team notes
National League Central
Chicago Cubs
Interim manager Bruce Kimm isn't getting hung up
on the "interim" label. This being his first major league managing job, he is
going to try to make the most of his opportunities.
"I don't pay attention to that," Kimm said. "To me, it's
fair. I'm getting an opportunity. It doesn't matter whether I have an interim
tag or not. I'll go about my business in the same way."
While some feel the Cubs would be better served by bringing
in an experienced veteran like Tom Kelly, Buck Showalter or Felipe Alou, Cubs
general manager Jim Hendry hired Kimm and wants to give him every chance
to succeed.
Meanwhile, Sammy Sosa, who tended to a family emergency
and was not with the team in Atlanta for the first two games Kimm managed, met
with his new skipper right after the All-Star break. The meeting went well according
to both parties.
"Everybody knows he's the manager now and he doesn't have
to do anything to show that," Sosa said. "It's too early for him to feel pressure
(about retaining his job)."
Cincinnati Reds
The club finally was able to address one of its major
needs for the second half run when it acquired right-hander Ryan Dempster
from Florida. And it addressed a second problem in the same deal by finding
a taker for outfielder Juan Encarnacion.
Dempster gives the club the potential top-of-the-rotation
starter it needed. Disposing of Encarnacion eased a crowded outfield situation,
one that was expected to pose a problem for manager Bob Boone when center
fielder Ken Griffey Jr. was ready to return.
When Griffey came off the DL in late May, Boone had to
rotate Adam Dunn, Austin Kearns and Encarnacion through the other
two outfield spots. Sometimes he moved Dunn to first base and benched Sean
Casey. When Encarnacion wasn't in the lineup, he pouted and once had to
be stopped by right-hander Jose Rijo from going to Boone's office to
demand a trade.
"Let's face it, the rotation system was not working," said
general manager Jim Bowden. "So we were able to address our starting
pitching and the outfield situation with one trade."
Even though he added Dempster, Bowden isn't stopping. He
is still looking for more pitching, with most attention paid to Detroit's Brian
Moehler, Baltimore's Sidney Ponson and Jason Johnson, the Mets' Shawn Estes
and Jeff D'Amico, and the Cubs' Jon Lieber.
"We're not going to bring him back until he is as close
to 100% as we can get him."
Houston Astros
General manager Gerry Hunsicker has been working
the phones trying to see if a trade is possible. Several baseball officials
said the Astros inquired about Jeff Weaver before the Detroit right-
hander landed with the Yankees via a three-team trade.
"We're certainly out there talking to clubs, primarily
in the pitching area," Hunsicker said. "The tough thing for a contending club
is to better yourself without weakening your club in another area."
The threat of a strike ending the season also has Hunsicker
weighing the value of acquiring a player for a postseason run when there's no
guarantee a strike won't kill the World Series, as it did in 1994.
Hunsicker says he will see how much ground the Astros make
up in the division race over the next two weeks before deciding.
Hernandez played catch for eight minutes from about 60
feet. He isn't expected to return until late July or early August.
"It felt a little strange because of the time I had without
throwing a ball," he said. "But I felt really good. It was only 60 feet."
Mlicki, who was scheduled to throw no more than three
innings or 50 pitches, threw three scoreless innings. He scattered two hits
and one walk with two strikeouts. He threw 45 pitches, 29 for strikes.
"I'm glad to see you saved up the home runs for the team,"
rehabbing right-hander Doug Brocail told Berkman, who hit only one home
run to finish last in the derby July 8.
Milwaukee Brewers
After a good stretch leading up to the All-Star break,
the Brewers started the second half playing like a scuffling, last-place team.
The starting pitching was inadequate during a series against
Pittsburgh in which the starters posted a 6.75 ERA. Manager Jerry Royster
has said he accepts the young starters will be somewhat up and down, but left-hander
Glendon Rusch and right-hander Jamey Wright, expected to be the
stabilizers of a young rotation, had the worst outings of the four starters.
Only right-hander Ben Sheets, who pitched the series
opener, lasted more than five innings, but the Brewers managed just two runs.
The problem was a familiar one for the Brewers: a lack of clutch hitting.
For the series, the Brewers were 4-for-40 with runners
in scoring position. The Brewers stranded five runners at third during Sheets'
"We can't miss opportunities; we're not good enough to
miss opportunities like that," Royster said. "We have to do all the little things
right, and that's what we were doing when we were winning. But we have to do
it from the first through the ninth."
"I still swing at bad pitches, but when I get two strikes
I can probably let a bad pitch go," Hernandez said. "I hope I can do it all
the time. But I'm only human."
Pittsburgh Pirates
With the July 31 trade deadline approaching, the Pirates
could be poised to make some kind of major deal.
A trade on the table with Colorado would send three-time
All-Star catcher Jason Kendall to the Rockies for former Pirates left-hander
Denny Neagle. The sticking points to the trade appear to be no-trade clauses,
deferred money, and the Pirates' insistence on the Rockies adding another player
to the deal.
Kendall and Neagle both have full no-trade clauses in their
contracts. However, both are believed to be willing to waive them in this potential
trade. Kendall would be reunited with his father, Fred, who is Colorado's bullpen
coach, while Neagle would leave the Rockies, who demoted him from the starting
rotation to the bullpen just before the All-Star break.
If the deal is made straight up, the Pirates could save
$13 million over the next five years.
Meanwhile, rumors concerning left fielder Brian Giles
also persist. Oakland appears to have the most interest in him while Baltimore
and Seattle are also considered potential suitors.
Giles can block a trade to any of those three clubs with
his limited no-trade clause, which allows him to be dealt to only Arizona, Atlanta,
Colorado, Los Angeles, San Diego or San Francisco without his permission.
St. Louis Cardinals
Left-hander Rick Ankiel, out all season with elbow
problems, got the second opinion he was looking for. Surgeon James Andrews agreed
with the opinion of the Cardinals' medical corps, that surgery was not necessary.
But Ankiel, 22, was told not to throw a ball for eight weeks, which effectively
rules out a return to the majors this season.
Ankiel's season ended with him pitching just two innings
in a spring-training game. He had been assigned to Class A Peoria in June but
was unable to pitch for that club, although he got to the mound one time.
The Cardinals don't have much in their system, especially
in the upper minors. They have prized right-hander Jimmy Journell,
who was just promoted to Triple-A Memphis, but Journell has been shut down
temporarily because of shoulder stiffness.

subset: commoncrawl


text:
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Would you like to be a member of our research panel? Join here - there's (nearly) always a great incentive offered for your views.
9w+5d pregnant - work and snow(50 Posts)
work do not officially know I'm pregnant although I have overheard two directors gossiping about the fact I am, so unofficially they know.
I have a 14 month old I need to pick up from my MIL and worried about getting there and back home (it's a tube rifde away from home) from work all in the snow when I'm pregannt, plus with a pram.
I really need to leave now and have asked if I could leave earlier but they've just said to keep an eye on the weather. I have and it's getting heavier.
what shall I do? I'm petrified I'm going to slip and miscarry. I';m actually in tears at the moment.
shall I bite the bullet and tell work I'm pregannt (they've sent a 14 week pregnant woman home who also has to pick her her child) and hope they send me early? I was hoping to keep it a secret until the first scan as it's a very gossipy environment.
Under the Health & Safety at Work act your employer has a duty of care to all its employees. Regardless of whether you are pregnant or not you should be able to get home safely and if that means leaving work early then so be it.
Also as you already have a child you have a right to excused absence as a parent to tend to their needs.
I would say that you just want to be on the safe side and sort out your DC before the snow gets bad.
If it helps, I'm in Southampton where it's been snowing since 3am and hasn't stopped - I now have 6 inches of fully settled snow
I would go. The pregnancy shouldn't come into it at all.
I'm not sure how you being pregnant affects this? Even if you did slip over it is extraordinarily unlikely to affect your pregnancy in any way, particularly at a stage when everything is safely packed away within the pelvis. Picking up your other child obviously will affect your plans though.
vinegar you're not sure how being pregnant when it's icy and snowy is an issue?
It's my concern that if I did fall over there is a chance of miscarriage. how likly this is to happen whether i fell or not ir irrelavent to me. what is relevenat and a concern to me is the fact that the risk - whether it be small or not, is still there.
as i have miscarried previously i am always cautious during pregnancy.
Obviously my company feels the same way having let another pregnant women leave early - she has annouced it where as I haveb;t.
anyway I don't think i need to justfiy why as a pregnant woman I am cautious about slipping over when it's icy and snowy.
Can I suggest you get yourself some snow grips for your shoes? They're about a tenner in millets/north face etc and you will be a lot more stable on your feet.
Maybe the other woman had to collect a DC from a closing nursery? Your DC is with family so perhaps in the eyes of your employer there is no pressing need for you to collect?
Your DC is safe with his/her grandmother. Presumably if conditions really get that bad, she can safely stay there for a while, maybe until DH can collect if you're really that concerned about going out. I'm sure no GM would refuse in an emergency. But, you're in London (near the tube) so conditions really aren't going to get that bad before the end of the working day.
I'm sorry if I sound unsympathetic, maybe I'm in a foul mood, but this is why some employers are reluctant to employ women.
I would just politely ask to leave early to make sure you can pick up your child, and offer to make up the time by arriving early/staying late on another day. Pregnancy doesn't need to come into it.
I work in London and live in outskirts and have left early- my employer was absolutely fine and i said I would log on from home so not a problem. My main concern was getting stuck on an absolutely packed tube (I have found travelling v difficult and have fainted this pregnancy) and also I wanted make sure I would be able to pick up DD from childminders
I think you are perfectly entitled to have added concerns in the snow when you are pregnant.
Good luck getting home !
Sorry but I'm another who doesn't understand the relevance of pregnancy to snow ! I am 18 wks and walking around as usual - obviously I wear suitable footwear to prevent slipping - but with fresh snow you are less likely to slip over than when the pavements are icy (much more regular at this time of year and surely you wouldn't avoid work whenever this occurs.
Noted - remind me - an emotional pregnant woman whose miscarried before and and scared to slip on a patch of ice not to come here for sympathy again.
Thank you ttcmay by the way.
Ignore them
Some people in this world, sadly find pleasure in making someone else feel shit.
Hope you got home safely x
I think you need to remember that in pregnancy you are often more emotional and anxious than usual and it seemed as thought you were asking whether or not your fears were rational. Sorry if you were not asking for views about the risks to your safety which is what I thought you were asking. If you do feel you were being rational then of course you should have insisted on leaving, not asked a forum whether you were doing the right thing.
Hope you got home ok.
I was being rational. Its starkingly obvious as a pregnant woman its a good idea not to fall over...when there is adverse weather like snow and sleet it makes the risk of injury increased. Its obvious and simple and for life of me cant see how such a thing can be debated. It seems alot of people here will argue or take an opposing view no matter the subject matter.
Lets look at this rationally - there was settled snow outside my work, it was getting heavier and colder certain troden areas turned icy. I am pregnant and voiced concerns as to slipping and miscarry...and I was met with comments telling me I'm absurd and the implication that in the history of time such a thing has never happened.
In the future save the debate for aibu.
Thank you mcphee and mutley, I got home fine although I slipped about in places...not a fan of snow in london as it turns patchy ice very quickly.
The reason that there is little sympathy is that do not cause MC in the first trimester. Possibly your bosses know that too, and djustments made for PG are based on evidence. There was no medical issue here. So what is left is the emotional need, and that is not a workplace matter - you are employed to do a job.
The suitability of your commute/childcare issues is your responsibility, not your employers. If you're commuting across London regularly, the you should certainly consider getting one of the narrower and lighter pushchairs rather than using a pram.
That said, I do sympathise with the emotional needs you have described, suggest you seek support in RL. If you feel you are no longer capable of doing your job, because of stress or other MH issues, then see a doctor.
And had this been posted by a well known/loved regular, the advice and outcome would have been different. Fact!
I think some people are just up for taking their own rl issues out on an invisiab;e person, for their own ego.
Come and have a go at me, instead of a worried mother to be....I couldn't give a toss.
I find this really interesting - it wouldn't occur to me that at any stage of pregnancy I couldn't go out as normal in the snow (with care being taken not to slip) - I can't see that it is rational for me to stay in for the next week while there is likely to be snow on the ground. What do pregnant ladies in Canada do?
Of course I understand you feel emotional and worried about it. I feel anxious about driving in this weather. However I can't see that it warrants "special treatment" on the basis of being pregnant.
I have also suffered 3 miscarriages. I don't believe any of them was caused by anything - miscarriages are sadly just one of those things. So presumably that affects my behaviour.
Wow some incredibly unsympathetic ladies on here.
I was worried about slipping in the snow too. It's your body and your baby and you've had an upsetting time in the past. Today I was meant to be going to see friends, 2 trains and a tube ride away with fairly long walks either end. I decided not too go as realised it would take me forever to waddle to the station trying to not fall over. My friends were very understanding. I'm sorry you've had a negative reaction on here. If its snowing on Monday my employer tells me to work from home. Hope you have a good weekend.
Oh dear god. Lets get a few things straight:
1. I do not feel I cannot go out at all when it snows. I have in no way ever said or implied this.
2. I do feel that when there is adverse whether caution and extra care should be taken b everyone, ESPECIALLY pregnant women, as a fall can cause a miscarriage.
3. Having previously stated I have miscarried (incidently around the week I am now) I am lightly more cautious, and the adverse weather hasn't helped this feeling.
4. I feel more than capable of working and do not need to seek help in rl. However, not many ppl know i am pregnant as I am under 12 weeks, hence coming online for "support".
5. Just so we're all clear what I am saying here - I am capable of working when pregnant, I did up until 9 months with my first. I am capable of commuting in the snow and during adverse whether. However i feel extra care should be taken and extra consideration should be given to pregnant women during said adverse weather, because an accident is more likely to happen during adverse weather. If you are pregnant and you do not wish to have extra time to complete your community during bad weatger, by all means, don't. I however, I was voicing concerns because I am pregnant. Did not want to slip and fall in the icy weather, and have a toddler to pick up and commute in the heavy snow (which it was a the time of writing yesterday).
This is all I wish to say on this issue. By all means if some of you wish to continue being argumentative, please be my guest.
And for the record meditrina I am extremely offended that you have insinuated I have mental health issues simply because I have voiced concerns at slipping over in the snow when pregnant. I gave no indication I have MH issues and have simply said I am extra cautious about miscarrying because I have miscarried in the past. Insinuating I have MH issues over this is extremely offensive - especially to ppl who genuinely have them, and should not be banded around loosely.
You will see from the link I posted that falls do not cause first trimester mc.
I am concerned from your post that your emotional state is disproportionate to your circumstances. You are of course right that there are many possible reasons, and MH issues (depression, anxiety; leading to irritability and aggression) are common. Your apparent over-reaction to a neutral statement about your well-being reinforces why I am concerned for you. There is nothing offensive about concern over MH, and there ought to be no stigma in considering it. It wasn't 'bandying': it was a suggestion framed in terms of getting proper medical advice. It is up to you to decide whether you do this or not, but I hope you will at least think about it.
Meditrina I find your insinuation offensive too. No, mental health issues aren't something which are swept under the carpet, but for gods sake women. I think you're making your own thread up here
May I suggest, that before you go around telling people they may have mental health issues that you.....well do you know what....If I type what I want to say I will be banned.
I've never come across such a down right rudeness....
I'm not really sure why there has been such issue with regards to the OP question. I am 11 weeks and it took me twice as long to walk home from the station as usual last night because I was absolutely terrified of falling over.
I was also in the position where I almost told one of managers that I was pg because I was worried about getting home and wanted to leave early. Except I was saved because he said at 2 that everyone could go home.
I think there is a lot of judgemental comments from other posters on here and I think just a simple recollection of the worrying that occurs with early pregnancy would have been a bit kinder to the OP.
For what it's worth I sympathise and I think as your colleague had been sent home maybe a quiet word in the ear of your boss might have been a good idea.
I hope there is no more snow! Good luck with your pregnancy!! X
OP - I think you've answered your own Q, no? The other lady has told them she's pregnant, you have not.
If it is that concerning for you, tell your managers. Then they will be able to take into account any particular H&S concerns.
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text:
Ask Mac Questions and Get Answers from Experts ASAP
Sorry I have a 10.5.2 Should we go on Chat?
and a patch disc of snow leopard 10.6
Still spinning
No Different
You sure its just C
Ok Stand by just got there
i followed the steps and itsaid HD had no errors but after re starting it is still just the spinning gear and apple logo. ANy other options?
With the CD out Right
OK went to the Grey screen again with spinning wheel
after a bar cam up at the bottom
as if it was loading
It first started with a bar at the bottom then when it went all the way across I am now still with the spinning wheel and a grey screen
Want to Chat it may be easier?
Grey Screen still spining
Ok I guess this is going to take awhile I'l talk to you tomorrow


text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Dihydropyridine Ca2+ channel blockers (CCBs) are widely accepted in the treatment of premature labour. Their mechanism of action in tocolysis involves the blockade of L-type Ca2+ channels, influenced by the Ca2+-activated K+ channels, beta-adrenergic receptors (β-ARs) and sexual hormones. In clinical practice, most experience has been gained with the use of nifedipine, whose efficacy is superior or comparable to those of β-agonists and oxytocin antagonists. Additionally, it has a favourable adverse effect profile as compared with the majority of other tocolytics. The most frequent and well-tolerated side-effects of CCBs are tachycardia, headache and hypotension. In tocolytic therapy efforts are currently being made to find combinations of tocolytic agents that yield better therapeutic action. The available human and animal studies suggest that the combination of CCBs with β-AR agonists is beneficial, although such combinations can pose risk of pulmonary oedema in multiple pregnancies and maternal cardiovascular diseases. Preclinical data indicate the potential benefit of combinations of CCBs and oxytocin antagonists. However, the combinations of CCBs with progesterone or cyclooxygenase inhibitors may decrease their efficacy. The CCBs are likely to remain one of the most important groups of drugs for the rapid inhibition of premature uterine contractions. Their significance may be magnified by further clinical studies on their combined use for tocolysis.
Pre-term birth (PTB) is one of the main clinical problems in obstetrical practice. The incidence of PTB may differ in different regions, the rate varying worldwide in the range between 5–11% [
Uterine contractile activity is regulated by the increase in intracellular Ca2+ concentration in the myometrial cells. Voltage-gated Ca2+ channels (VGCCs) mediate the Ca2+ influx in response to membrane depolarization and regulate intracellular processes such as contraction [
The voltage dependent L-type calcium channels have been identified in uterine myometrium by electrophysiological, pharmacological and molecular studies [
The CCBs therefore arouse considerable interest for both therapeutic and experimental purposes [
The uterus contains BKCa channels and their expression and distribution have been shown to be gestation-regulated [
The adrenergic system plays an important role in the control of uterine contractility. Currently, β2-AR agonists are still among the most frequently used tocolytics, although their therapeutic significance in PTB is constantly questioned.
β-AR stimulants are known to produce smooth muscle cell relaxation by activating Gs proteins, and their Gαs subunit stimulates adenyl cyclase. This elevates the level of cyclic adenosine monophosphate (cAMP), which activates protein kinase A, this activated form inducing phosphorylation of the Ca2+ channels. This mechanism is well known in the heart muscle [
Another factor which regulates the L-type Ca2+ channel is the progesterone (P4)/oestrogen (E2) ratio [
Combinations of P4 and β2-AR agonists have also been investigated in the pregnant myometrium. P4 pre-treatment increases the expression of the β2-AR during pregnancy and alters the effects of β2-AR agonists on the pregnant myometrium; P4 and its derivatives have been considered as drugs against PTB [
It was been demonstrated that the mRNA expression of the pore-forming α1C subunit of the L-type Ca2+ channel is regulated by glucocorticoid hormones, but tissue-specific changes may occur [
Influence of some physiological factors on L-type Ca2+ channels in the pregnant myometrium.
|Physiological factor
|Effect on L-type Ca2+ channel
|Possible clinical relevance
|BKCa channel activation
|presumably increases the tocolytic effect of CCBs
|β-AR activation
|increases the tocolytic effect of CCBs
|Long-term progesterone effect
|expression of less sensitive form
|presumably decreases the tocolytic effect of CCBs
A number of drugs are used against threatening PTB, although only oxytocin antagonists have been designed specifically as tocolytic medication (
Nifedipine is used orally for both tocolysis and cardiovascular treatment. The appropriate dose of nifedipine for tocolysis is still under investigation. In a comparison of two dose regimens of oral nifedipine in a study on threatening PTB between gestational weeks 24 and 34, it was found that a high dose of the drug (20 mg loading dose, daily 120–160 mg for 48 hours, followed by 80–120 mg daily up to 36 weeks) did not have any advantage over a low dose (10 mg loading dose, daily 60–80 mg for 48 hours, followed by 60 mg daily up to 36 weeks) as regards uterine quiescence [
Class of drugs used clinically for tocolysis.
|Class of drugs
|Primarily licensed for
|The most frequent side effects
|Beta-adrenergic agonists
|bronchial asthma
|Maternal: tachycardia, hyperglycemia, pulmonary oedema
|Cyclooxygenase inhibitors
|inflammation, pain, fever
|Foetal: premature closure of ductus arteriosus, reduced amniotic fluid index
|hormonal substitution, contraception
|no relevant side effect
|Magnesium sulphate
|hypomagnesaemia, eclampsia in pregnancy
|Maternal: constipation, visual blurring, headache
|CCBs (DHPs)
|Maternal: headache, tachycardia, hypotension
|Oxytocin antagonists
|Maternal: tachycardia, chest pain
There have been reports of the lack of action of nifedipine in premature contractions. A placebo-controlled, randomized trial demonstrated that 20 mg of nifedipine administered every 4–6 hours did not maintain pregnancy or delay delivery as compared with the placebo group [
In twin pregnancies where nifedipine tocolysis was administered a switchover to subcutaneous terbutaline following hospitalization for recurrent symptoms of the threatening PTB had a positive impact on pregnancy prolongation and on the neonatal outcome [
In another investigation, nifedipine was found to be more effective than indomethacin in inhibiting uterine contractions during the first 2 hours; however, there was no difference between indomethacin and nifedipine in delaying delivery for up to 7 days [
Atosiban and nifedipine have been shown not to significantly differ in delaying delivery [
Nicardipine has the advantageous feature over nifedipine that its intravenous administration is possible, and it is the first choice for some obstetricians in the management of PTB. However, intravenous nicardipine does not increase the duration of pregnancy in comparison with oral nifedipine. The median duration between treatment for PTB and delivery was significantly longer when nifedipine was used [
Nicardipine was earlier found to be as effective as salbutamol in the treatment of PTB, and it was suggested to have advantages especially in cases of pregnancy accompanied by hypertension, diabetes or maternal cardiopathy [
CCBs are generally well tolerated. The most frequent maternal side-effect is headache which is associated with the transient hypotension caused by the loading doses [
Nifedipine was suspected of being responsible for severe dyspnoea in seven patients with multiple pregnancies. It was hypothesized that the complications were due to the imbalance in the ventilation/perfusion of the lungs in consequence of the diaphragm being elevated due to the pregnancy. These changes are usually more pronounced in twin pregnancies. The administration of nifedipine resulted in a ventilation-perfusion discrepancy and dyspnoea. These observations question the safety of nifedipine as a tocolytic agent in patients with multiple pregnancies [
A comparison of the side-effects of nifedipine and nicardipine revealed that the patients in the nicardipine-treated group had significantly more side-effects (31%
Maternal pulmonary oedema induced by the infusion of nicardipine was reported in five pregnant women during tocolysis. Therapy was discontinued immediately after the diagnosis, but two patients required admission to the intensive care unit [
The idea of combined tocolytic therapy with nifedipine is not new. The first report on effective tocolysis with a combination of nifedipine and beta-mimetic terbutaline was published in 1985 [
One study has been carried out to investigate the efficacy of combinations of CCBs and oxytocin antagonists for tocolysis. The combination atosiban + nifedipine exerts on additive tocolytic effect on the contractility of myometrial strips in both pre-term and term patients. Surprisingly, the combination nifedipine + celecoxib exhibited a weaker effect than that of nifedipine alone [
P4 analogues have been re-introduced into tocolytic therapy in the past decade as preventive compounds against PTB. For women with a history of spontaneous PTB, P4 reduces the incidence of PTB before 34 weeks, but has no beneficial effect in multiple pregnancies or in the event of a short cervix [
P4 pretreatment has been found to alter the structure of Ca2+ channels, promoting the expression of the less sensitive form of the channel, and to weaken the tocolytic effect of nifedipine in pregnant rats [
Myometrial effects of different combinations of nifedipine.
|Change in myometrial relaxation
|Risk of combination
|Nifedipine + ritodrine
|increased (in both human and animal studies
|pulmonary oedema, myocardial infarction
|Nifedipine + atosiban
|increased (in a human study
|no information (data from
|Nifedipine + celecoxib
|decreased (in a human study
|no information (data from
|Nifedipine + progesterone
|decreased (in an animal study
|no special risk as compared with nifedipine monotherapy
CCBs are increasingly used for tocolysis, although officially they are not licensed for this purpose. Their efficacy is at least equivalent to that of the traditionally used drugs, but their adverse effects seem to be milder and better tolerated than those of beta-adrenergic agonists and not more severe than those of oxytocin antagonists. Unfortunately, the CCBs in monotherapy are not better than other tocolytics in long-term tocolysis (pregnancy maintenance).
The effects of nifedipine in tocolytic therapy may possibly be intensified through their combination with other compounds. Their efficacy may be enhanced by low concentrations of β2-mimetics. However, the administration of β2-adrenergic agonists cannot precede that of nifedipine. There are a number of clinical findings that warn against the combination of these two groups in cases of multiple pregnancies and maternal cardiovascular disorders. On the other hand, their combination may be investigated in single pregnancies that require tocolysis. With regard to the limited nature of the information available from preclinical studies, a trial relating to the combined tocolytic effect of CCBs and atosiban may be reasonable.
Overall, it may be concluded that DHP CCBs should remain one of the most important group of drugs for the rapid inhibition of premature uterine contractions. There is an urgent need for an updated systematic review (e.g., according to the principles of Cochrane reviews) on the clinical application of CCBs in premature labour. Additionally, further clinical studies are required to investigate how to enhance their efficacy in combination with other drugs.
The authors declare no conflict of interest.


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OMA, Arduino and Sierra Wireless Workshop for IoT Developers
Join us in San Diego, CA for a free event for developers, makers and robotics enthusiasts interested in M2M protocols and hardware
We are partnering with The Open Mobile Alliance (OMA) and Sierra Wireless to present a free, one-day workshop for developers of Internet of Things (IoT) products and services. The workshop is targeted at makers, developers, robotics enthusiasts, and others who would like to receive hands-on training with OMA's Lightweight M2M (LwM2M) protocols. The workshop will take place on Friday, January 22 at the DoubleTree by Hilton San Diego – Mission Valley from 9:00AM until 3:00PM.
Field engineers will guide attendees step-by-step on how to install an OMA LwM2M client on a platform, open a connection with the OMA LwM2M server and read and manipulate sensor values exposed by the OMA LwM2M client. Attendees will have the chance to work with one of two platforms, including Eclipse Foundation's Wakaama client on the new mangOH™ hardware platform (a project led by Sierra Wireless) or an Arduino YÚN. Hardware platforms are limited and will only be distributed to the first 50 attendees to show up at the event.


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Mike Chapple is an IT professional with over a decade of experience in the fields of databases and information security. In addition to serving as the About.com Guide to Databases, he is the author of numerous books on the topic.
Mike's work experience includes time with the U.S. Air Force, the National Security Agency, the University of Notre Dame and Brand Institute. He is a technical editor for Information Security Magazine and the author of SQL Server 2008 for Dummies, the CISSP Prep Guide, Information Security Illuminated and several other titles.
Mike holds a BS in Computer Science from the University of Notre Dame, an MS in Computer Science from the University of Idaho, an MBA from Auburn University, and a Ph.D. from the University of Notre Dame. He holds many professional credentials, including Microsoft Certified Database Administrator, Certified Information Systems Security Professional, and Certified Information Systems Auditor.
You can read more about Mike at Mike Chapple's website


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Four-D College in Colton is offering an associate's degree program in health care administration in a traditional classroom setting - the only vocational school in the Inland Empire to do so, the college announced this week.
"Most programs offered by other schools are online, which is fine for those students who prefer online learning. However, most health care and nursing students I've come across say they much prefer the traditional classroom with face-to-face interaction," said Linda Smith, CEO and founder of Four-D College, in a news release.
The Associate of Science in Health Care Administration (ASHCA) program at Four-D College is fully accredited by the Bureau of Private Post Secondary Education. The program is 14 months.
The program focuses on preparing students to be health care administrators by concentrating on leadership, management, administration of hospitals, hospital networks, health care systems and public health systems.
For more information or to enroll in the ASHCA program, please contact the admissions department at Four-D College at 1-800- 600-5422.


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Wanna Be a Pop Star? Avon Wants YOU! (VIDEO)
Avon, one of the world's leaders in cosmetics, is hosting Avon's Voices, an online singing talent search for women. Two winners will receive the chance of a lifetime to professionally record an album and maybe become the next global superstar! In addition to the finalists receiving Avon makeovers, professional musical coaching and studio time, they also get to travel to an exciting destinations like Hong Kong, Hollywood, Rio de Janeiro, New York, Paris and Nashville. Start warming up those pipes, because the last day to enter is February 13th!
Stars like Natasha Bedingfield and Fergie give the contest lowdown. Take a look after the jump:
What are you waiting for? Head over to the website for full rules and to enter! Good luck!


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Tag Archives: secrets of deities
The Deities of Bhagwan, Their Sacrifices, Their Contributions and Ways to Communicate with Them
Ancient Hindus unearthed secrets of elements that created nature, planets and Universe. They considered everything as alive not for the sake of explanation but because they were able to interact with them - some of the aspects are proven by modern scientific experiments too. Vedas taught the world, thousands of years ago, that plants are living beings. It was recently re-discovered by Jagadish Chandra Bose's whose wireless inventions antedated those of Marconi. Right from construction of structures,


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Hi. This is my first post. I am a complete beginner and am working through the 'Build your own Website the Right Way' book. Everything has been going well (maybe too well!!!) and I have just finished Chapter 7 on Forms. My form looked fine until I did the work on the Freeback site. Once I had pasted all the alterations to the 'Contact' html, my lovely looking form changed. I have used the form and it works fine, sending me the information I requested etc ........ but it doesn't look pretty at all. It is as if it has lost its connection with my css .... the fonts in the form are the wrong colour, wrong size, the boxes for answers aren't aligned properly and the submit button has lost all the button area css. I have checked the code as carefully as possible and run it through a second time, but still no joy.I imagine this is a very simple issue but would be extremely grateful for any help. Many thanks:) John
Hi John. Welcome to SitePoint.
Is your site online yet? If you could provide a link, that would make it a lot easier to assess what's going on here.
Thanks for your quick reply.No this is not my own site, which I have hardly started yet.This is the example site, BubbleUnder.com used in the Sitepoint book. I have worked through the book creating the site as suggested. In Chapter 7 after creating a good looking contact form for the BubbleUnder site, the reader is asked to register with Freedback.com, create a form with them, then copy and paste parts of the code they create from your form questions, into the contact html for the BubbleUnder site. When I did this and saved my amended contact html, I then opened the contact page to find that the form had changed radically. As I said in my first post, it is as if the css has been lost from the form. The rest of the page is the same as before, it is just the formatting inside the form. I then filled in imaginary answers to the questions on my form and submitted it. This worked fine and I soon received an Email with these answers on it.I hope this clarifies my position. Many thanks. John
Hi, anyone who is reading this. I've found the answer to my problem ........... in a previous post. 'Build your own website Chapter 7 .... Conflict between CSS and Freeback.com form code'. This was posted on April 25 2010 by Strong. What a fantastic relief to read this and solve my problem. As a complete novice I am beginning to understand why you are all so addicted to this 'stuff' ............ you get such a buzz out of solving a problem!!!! Anyway thanks to 'Strong' and 'Mittineague' who had a good interchange of ideas on this subject back in 2010. You have made my day, guys!! Just for the record the problem lies in an error in the final code Ian Lloyd puts in the book on page 291. On the first line it should read <form enctype="multipart/form-data" class="contact" method="post" ......... etc. In the book the class="contact" is missing.I am really enjoying this book, but I wonder why this error has not been corrected already. I have the 3rd edition and only bought it a couple of months ago from Amazon so you would have thought it was a recent edition.Anyway, great relief all round. John.
Thanks for posting back, John, and well done for finding the solution yourself. It would be worth sending a message to SP HQ to alert them to the error. There is an errata page for the book, but it looks like no one has submitted an error yet. (As you say, if this was in the previous version too, that's a shame.)
Thanks for your post, ralph. I have Emailed Sitepoint so hopefully there won't be too many more puzzled readers when they reach this point in the book.
That's very disappointing but let's wait and see. I'll post any reply to let you know how I get on.
Personally I like mucking around with contact forms and there are some great and easy to use scripts out there. But one easy alternative is to use Wufoo because it doesn't need to be installed. It's an online form builder that is very easy to use. You can link it to your website so it looks like its just a normal form mail script. But if you don't have a website you can simply direct people to Wufoo and they can fill out a form there. (handy if you are running a one off campaign or contest).
It is a paid service but the do have a free version as well. My company used it for a campaign that we ran and that was the first time I'd ever come across it. It's amazing how much stuff is out there in a online - so you don't have to go to the effort to do any work.
Always a good thing!


text: First off I have 2 wireless routers. Belkin Wireless G plus mimo Model# F5D9230-4 Ver.3001 and a D-link Dir-615 ver. B2. I am using the Belkin router has my main router. The wife's laptop and the Wii console connect to the router wirelessly. I also connect a few PC directly to the router via Cat5 cables which runs through most rooms in the house. Since the router is down in the basement in my control panel along side the cable modem and what not. This causes the wireless single to be pretty weak in certain parts of the house. What I was planning on doing is taking the D-link router connecting it to the wall jack upstairs to the internet port on the router. Then setting both routers to static and changing the Belkin router to DHCP. Would this work? Thanks.


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I wonder if McNabb will be so nervous during the ceremony that he'll lose his lunch, like in the Super Bowl. He did a lot of throwing as an Eagle - for the highest total yards in team history - but I'll remember him most for throwing up, gagging when greatness was on the line.
The statistics say he's worthy of the honor, but they don't show the whole story. I'd rather see Randall Cunningham and Ron Jaworski receive that recognition.
I do believe that Donovan is deserving of this honor. He came to play for one of the most demanding and critical markets in the entire NFL and handled himself with incredible grace. He had little to work with in the beginning, but once they supplied him a top-notch receiver in Terrell Owens in 2004, they went to the Super Bowl.
Like most Eagle fans, he would drive me crazy with those passes to receivers' feet and his gaffe when he didn't know the rules about overtime. But overall, he's meant more to this team than anyone except maybe Brian Dawkins. He and Andy Reid turned this sorry team into a perennial contender. And he deserves this honor without a doubt.
Galloway Township
The one man that can make that decision, Jeffrey Lurie, has decided Donovan was his franchise QB and declared him the greatest in Eagles history. So, sure, retire his number. He was very good in the long playoff and championship runs. On the field and by the numbers, Donovan is very deserving of the honor. ... Now, Hall of Fame?? I don't think so!
Ocean City
As an avid, rabid, rowdy, and loyal Philadelphia Eagles Fan, I think it is an absolute TRAVESTY that the Eagles' brain trust is deciding to retire No. 5. Really? Why? No Super Bowl wins, a bad attitude, major ego, and basic loser quarterback who throws up in the huddle during a Super Bowl drive where everyone's counting on him to be a leader.
West Wildwood
Difficult to withhold that ultimate honor from No. 5, Donovan McNabb, when you carefully review what he did for the franchise. If only he had finished stronger in the 2004 Super Bowl and told a mouthy T.O. to just shut up, I'd be singing his praises even more.
Egg Harbor Township
He wore an Eagles uniform for 11 years and showed up on Sundays to play, but there has never been a NFL defensive coordinator who was concerned about developing a game plan to stop McNabb.
Very average QB who padded his statistics through longevity and Andy Reid's love affair with the passing game vs. having the superior passing skills and decision-making abilities that defensive backfields fear.
Acknowledge the time and effort he gave the uniform, but please, let's keep the accolades to a minimum.
Donovan McNabb was a great QB who took us to more playoff games and the Super Bowl than any QB that I can remember for the Birds. If he was supplied better receivers like (Terrell) Owens, the outcome of some of the playoff losses may have been different.
Yes, he did throw the ball at the feet of his receivers, but he made more big plays with his arm and legs to offset the bad over his career. He played hurt in many games and he was never a fan favorite. McNabb will be more appreciated in the future for what he did then when he was playing. For sure he deserves his No. 5 retired.
I don't think (he) was the best quarterback to ever wear an Eagles uniform. He was no Van Brocklin, Thompson or even Jurgenson. He was in the same league with Jaworski and Cunningham and better that Norm Snead and the rest of them, but yes, his number should be retired.
He started more years, he has the stats, and we can only wonder what he could have accomplished with premier receivers over his entire career. I don't think he is even colose to being Hall of Fame material, however.
Egg Harbor Township
While his play often sent me over the edge, Donovan McNabb deserves to retire as an Eagle.
Egg Harbor Township
I am delighted that the Eagles are honoring Donovan in this way. He has earned this and deserves to be up there with Reggie White and the rest of the extraordinary Eagles.
I will always remember him playing hard through his injuries, never complaining.
He has taken his classiness on the field and applied it to his personal life as well. His bio will be squeaky clean because he has conducted himself with the utmost of care.
His records will stand, his number will be retired, and we will always remember the man behind that great smile.
Little Egg Harbor Township
I believe that to retire Donovan McNabb's jersey and his number is really good. He played well for the Eagles for many years. He helped make the Eagles a good team. He did well for this city and the team.
Surf City


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I wrote an essay published recently by the journal Design & Culture. The abstract is below. The article may be downloaded here:
This article encourages instructors to redesign the classroom. Finding the balance between service to students and to one's own work has become increasingly difficult for professors. A recent overhaul of the BFA program in the Graphic Design Department at The Rhode Island School of Design has created an opportunity for faculty to bring their own areas of interest into the classroom. The results so far have been more interpersonal connection, more diverse outcomes to projects, and an agile core curriculum.
Profile of RISD Graphic Design from AIGA's Eye on Design magazine. Read the story
I'll be on a panel with the heads of Parsons and CCA (Yu June Park and Rachel Berger, respectively) to talk about design education. Moderated by Juliette Cezzar and Brin Smith. Hosted by AIGA NY.
Monday, June 6, 2016, 6:30–8:30pm.
Starr Foundation Hall, Room UL102
63 5th Avenue
I just returned from Lebanese American University, where I gave two lectures (one at each campus) and am writing up a program review. Thanks to everyone at LAU for an excellent few days … an opportunity to think about graphic design education and, in particular, its place in the Middle East.
I gave a 20 slide Pecha Kucha talk about the HTML Output course at AIGA New Orleans in October. See presentation notes from myself and other speakers
Mitch Golstein, co-founder of the podcast ThroughProcess, came to Providence to talk with Professor Lucinda Hitchcock and me about design education.
I was asked by Design Observer to contribute the story behind the making of my 2004 graduate thesis, Take Your Time.
Thanks to the students and faculty for a great visit to the Art Department at the University of Delaware.
Four HTML Patterns, the for/with/in book and demo video are on display at RISD's Architecture Dept. Gallery until March 20th. The show is titled "Six Lines," and accompanied a panel with RISD professors on their relationship to tools. More information and documentation is available at risdtool.org
I had a much needed snow break at the California College of the Arts this week. There I talked with students and faculty of the Graphic Design Department about how the web browser can be used as a general purpose design tool. Photo via CCA Facebook page
I'll be giving a 15-minute overview of my work in designing information, information systems and organizational systems. Three other speakers will be in attendance, followed by a panel with all of us. At Aurora in downtown Providence. Thursday, Sept. 25 from 4-6pm.
More info at http://designweekri.com/events/
Read my essay reflecting on design at the AIGA's 100th anniversary.
I led a panel about design & education with Ellen Lupton, Jessica Helfand, Prem Krishnamurthy and Andrew Blauvelt. It was part of a daylong series of conversations in the "Critical Encounters With Type, Image and Print" program at the RISD Museum in April of 2014
From the Magazine: "Identity, wayfinding and daily guide for Locally Made, the RISD Museum's exhibition of Providence-area contemporary art. The daily guide and wall treatments make sense of 300 artists and 180 live performances scheduled over four months. The guide is printed on demand from a high-speed thermal receipt printer on blue paper. The title signage uses the receipt rolls, anchoring the printing process to the entry of the exhibition, offering an expressive and joyful tone." Typefaces: Fort, Perfin, Simplon.
Designed in collaboration with six fellow Design Office members. Learn more
I was awarded The Design Innovation Grant from the Rhode Island State Council for the Arts. More information and the full list of grantees from 2014
Visit RISD Works on North Main Street in Providence to buy one of five cards designed by Design Office members. I submitted the first and the third card pictured, both patterns created in the web browser.
See the original post on Design Observer
I will be giving a lecture as part of Brown University Library's Digital Scholarship Lecture Series. I will show my work designing data-driven software systems for designers, educators and the general public.
Thursday, Nov. 14, 5:30pm at Brown University's Rockefeller Library
A WordPress theme to encourage sharing and discussion within the classroom and between institutions.
More information at charrette.ws
My fellow members of The Design Office and I have just finished designing, producing and installing the exhibition graphics and a print-on-demand daily guide for the RISD Museum's upcoming show, Locally Made.
Please visit the show from July 18 until November 3rd, 2013. More images to come.
More information and a list of artists available at the RISD Museum website
The design of the Skolos-Wedell Highsmith poster and bookmark project received a "bone" from the Boston chapter of the AIGA. The cast-iron "Best of New England" awards are given to top design projects (of all sorts) created in the last two years in New England.
The 2013 contest was judged by Lucille Tenazas, Elliot Earls, and Stewart Smith
More information at http://boneshow.org/
I am pleased to be a part of Michigan State's Art/Art History/Design Lecture series for this year. I'll be lecturing on January 31 at 7pm in South Kedzie Hall.
There is more information available on the Michigan State website
I will have two photographs on exhibit at the Providence Preservation Society's annual "Ten Most Endangered Properties" exhibit. I was asked to photograph the George C. Arnold building on Washington Street in downtown Providence. Both images were photographed with a large format field camera on Kodak film and printed at The Design Office.
An opening reception will be held at the Brick School House, 24 Meeting Street, on Thursday, November 8, 6:00–8:00 p.m. The event and reception are free and open to the public.
More information may be found on the PPS website.
I'll be lecturing on WordPress for Teachers on Saturday, October 27 at WordCamp Providence. I'll share how I've been integrating WordPress as a classroom accessory at RISD. The talk will be about pedagogy, design and WordPress theme development.
More information and registration information
Video from the event:
I have moved The Design Office from the 4th floor to the 3rd floor of 204 Westminster. There are 12 desks and 2,500sq/ft of workspace. As part of this move, I commissioned Anther Kiley to design a sign that reinforces the architectural distinction of the building and directs visitors to the building entrance with an arrow. During this process, two RISD student groups became a part of the burgeoning arts building on the first floor. We hope the gallery and materials resale shop settles in for the long term.
I am pleased to announce that I will be joining the full-time faculty in graphic design at The Rhode Island School of Design. I will continue to work as an independent designer and run The Design Office.
Join me from 5:30 until 6pm, Thursday July 19, 2012 to discuss the timeless considerations of letter forms in a Greek carved stone tablet.
More info
Picture from the event (courtesy of the RISD Museum):
New Vintage Digital Vernacular Letters
The show will run from February 1st – March 31st. The opening party is Friday February 3rd
The free drinks will begin promptly at 18:00.
From the gallery website: "Thanks to digital cameras, smart phones, nearly unlimited storage space, and online social sharing it is easier than ever to capture, collect, and share images. Particularly exciting is the now relatively mainstream pursuit of photographing interesting found type and lettering. Whether it is encountered in one's neighborhood or stumbled upon while traveling, there is seemingly no end to unique letters to be collected. This phenomenon is illustrated through dozens of blogs dedicated to found letters, to Flickr's countless tagged images of type, and by sites like we love typography – currently with 12,000+ curated images."
I'm pleased to announce that Contact Sheet is ready to use. After months of testing on The Design Office website, the open-source plug-in is documented and downloadable at http://cs.thedesignoffice.org.
I'm happy to announce that we've relaunched The Design Office website, still at http://thedesignoffice.org
The website provides a better look inside the space by showing off its physical environs, profiling the people who are or have been involved since the beginning, providing specifics on how any designer can get involved, and listing a catalog of member-initiated projects.
The website also launches several projects and initiatives:
I was one of ten photographers asked by The Providence Preservation Society to photograph a building they deemed vulnerable to demolition. I chose the Teste Block building around the corner from The Design Office at Weybosset and Dorrance Streets. Taken with my Linhof 4×5 camera, this 20×25″ print shows the ultra-thin building from the 4th story of the Dorrance building nearby.
The opening is Thursday, November 17 from 6pm until 8pm at the RISD architecture department at 231 South Main Street.
The show runs until December 3rd. Do try to make it. The hours are listed on the PPS website.
Driving tour of eight residential structures in the Providence area designed by Mr. Rakatansky, with exclusive access to some interiors, and exterior tours of others. Tour participants will provide their own vehicles and will be given a map of all locations, including tour start, upon ticket purchase.
This is a paid event. More information on the tour from Docomomo.
Below is the itinerary for the October 9th tour:
View Docomomo Ira Rakatansky Tour in a larger map
In reflecting on Steve Jobs' many accomplishments, I return regularly to his role as a leader. When considered alongside other visionaries responsible for ground-breaking designs (think Frank Lloyd Wright and the Eames), Jobs also ran a multi-national public company. As his career progressed, he became the actual, and adopted, chief of more and more people: from geeks, to designers, to animators, to musicians, to telecom workers, to retailers, etc. Whether they worked for Apple or not, people associated with those fields voluntarily chose him as their leader — me included.
Jobs' passion and drive was enough to attract followers, but with blockbuster product after product coming out, he had everyone listening. What makes a new Apple product great is that it's unimaginable before it's released, but once it is, we can't think of a better solution. This happened again and again, always with Jobs on stage grinning enthusiastically as he revealed world-changing designs. You can relive these moments in the now legendary videos of the release of the Macintosh and the iMac and the iPod Nano. In his Facetime chat with Jonathan Ive during the iPhone 4 release, he said that he grew up with the Jetsons and that the day had come to make video calls. We all smiled with him. It was as if he had landed on the moon. But unlike space travel, he was going to take us there with him.
The emotional void from Jobs' death makes me ask questions of those who remain on top — the elected politicians, heads of universities, corporations and non-profits. Do they skate — as Jobs and hockey player Wayne Gretzky once did — "to where the puck is going to be, and not to where it has been"? What visions do our leaders have? Where do their passions lie? Will they learn from Steve Jobs to not conduct polls, or cut corners, or make excuses, or settle for less? If they do, I will support them as a voter, as a customer or as an admirer.
Rest in peace, Steve, and thank you for your leadership and inspiration.
I am moderating a panel this Sunday that includes top practitioners in the field of communication-based design: Julia Vasker from Hyperakt, Scott Stowell from Open, Lindsay Kinkade from Little Giant and Steve Duenes from The New York Times graphics department. The panel is part of the Brown and RISD student-run conference, "A Better World by Design," a completely student-organized conference that places innovation and impact over individual success (their words).
We'll be at Brown's Granoff Center, Studio 1, on Sunday October 2 from 9:30am to 10:45am.
You must register in Salomon Hall (Brown University green) to attend — starting at 8:30 am on Sunday or from 8am to 6pm on Saturday.
W More information at abetterworldbydesign.com
Updated Oct. 4
Design process is not a conveyer belt, but a group that works together from beginning
Julia Vakser couldn't remember the last time one person took a project from start to finish. I wonder how collaboration works as equals? Subcontracting is one thing, but "co" laboring is another.
When you start out, don't just take work to pay the bills. You might find yourself doing that 15 years later. Scott Stowell
Do what you're passionate about says Lindsay Kinkade
Design is a conversation not an end form. Lindsay is wrestling with how to show the work she's doing because it involves facilitation and culture change.
Design is about systems/modules/parts that can be put to work. Gone is the perfect end form. Scott spoke of making posters like churning butter — not so common.
Concept (Scott) and content (Steve Duenes) are way more important than the end form. If the client is talking about color, then the concept is home free. (Scott)
Scott showed a big green dot as a solution to a logo for "the big green planet." He said there were many proposals just like it, but they liked his the most. I wonder was it the presentation? The people? The portfolio backing it up?
"Not all films need to be documentaries"
Work that ends up not as you want can simply not be promoted … except if you're The New York Times, then you have to wait a day to disown it.
Workers after Sept. 11 cut out New York Times maps and used them onsite to do their work
Lindsay's work on health communication that reduces errors in hospitals
If you want to change the world, you need to know what's going on in the world said Lindsay. She and Scott praised the New York Times' work.
Support the AS220 darkroom and walk home with one of the 150 photographic prints donated. I submitted an unpublished photograph from the Ira Rakatansky monograph. Works from Jack Pierson, Nan Goldin, and the sea of local Providence talent are also available and on view from now until the September 24th lottery.
More information on the AS220 site
Register for "Web Design" and "Data-Drive Design", two courses that I'm teaching this summer as part of RISD's Summer Institute for Graphic Design Studies. Find out more
Update: Web Design course is full!
Update: Web Design class site
This domain turns 14 years old today. I still have the original portfolio page archived, although the links don't work. That's the original jc green (as it was referred to).
I'm celebrating domain registration renewal day by launching my archived portfolio using the Flatfile website template. Featuring a slightly updated jc green, the site shows a decent overview of the last 14 years. Particularly light are graduate school projects from 2002-2004, works from Italy in 2005 and my recent works with Brown University's Watson Institute.
An anniversary waits for no one, so today this launches, and "tomorrow" I'll add some more content.
Thanks for visiting.
After 9 months in the making, I am happy to introduce Flatfile, an affordable website solution for artwork.
See the overview page for pricing and features
The unofficial catalog is John's submission to the Biennial. Created in three days, the Flatfile kiosk organizes more than 200 artists and 400 photographs. Visit the RISD Museum before March 20 to see the project.
I'll be presenting 20 slides at 20 seconds a slide at AS220 on Feb. 23. Exact time to come. And February 24 is RISD Faculty Biennial, where you'll see Flatfile in action as the unofficial catalog of the 205 works in the show.
Experiments with 3-D typography from Yale have been included in the book Font Family published by Index Books in Barcelona.
New York buyers can pick up the Rakatansky monograph at the MoMA store in Soho.
Three of my photographs are in the second volume of The Encyclopedia Project. Published out of Los Angeles by former Brown University fiction students, the book integrates fiction, poetry and visual art to make part reference/part literary journal.
I designed the site for performance artist Marc Horowitz's latest project, "The Advice of Strangers."
Starting today for one month, he'll be asking you to help him figure out what to do with his life. He posts questions and possible outcomes, users vote.
RISD Alumni Lecture Series
Ira Rakatansky '42 ARCH
Mentored by Walter Gropius and Marcel Breuer, RISD and Harvard Alumnus Ira Rakatansky's architecture celebrated the best of the Modern movement.
Join us for cocktails and conversation with Ira, RISD Architecture Head Lynnette Widder and Critic John Caserta, the co-editors of Ira Rakatansky: As Modern As Tomorrow, a new monograph in the RISD Architecture Series.
Cocktails at 5:30, to be followed by a lecture and book signing at 6:30.
Oct 27, 2010, 5:30 – 8:00pm
Chace Center Lobby/Metcalf Auditorium
The RISD Museum
20 North Main Street
Letterboxes has a page in the Jeanette Abbink and Emily CM Anderson's book 3-D Typography. The book is full of projects showing type off the page.
B More information about the book
At noon on Thursday, October 28, 2010, we will print the poem "Fall Leaves" by Brazilian designer Guilherme Falcão out of our window in downtown Providence. Written in response to our call for submissions, "Fall Leaves" is 2-feet wide by 24-feet long and will take about two hours to print from our 4th floor office at 204 Westminster down to just above street level.


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Chris Weinke is training three quarterback prospects for the Feb. 22-28 scouting combine and the April 26-28 draft, but he has encouraging news for any team considering signing Peyton Manning, should the Indianapolis Colts do the expected and move on from Manning rather than pay a $28 million March 8 option bonus.
The 39-year-old director of the IMG Madden Football Academy in Bradenton, Fla., returned to lead Florida State to a 1999 undefeated, national championship season after undergoing spinal fusion surgery in November 1998 similar to what Manning underwent last Sept. 9.
Weinke has shared his experience with Manning and thinks four-time NFL MVP will return to play again at a high level as he continues his rehabilitation from four surgeries, including one that was not publicly acknowledged between last May 23 and that September anterior fusion surgery, according to SI.com.
"I've spoken to Peyton early on in the process,'' Weinke told USA TODAY Thursday. "My gut feeling: It's not a question of if he can get back healthy because it's already been proven it can happen because I went through it.
"It comes down to Peyton and what he wants. My gut tells me he wants to come back and play. My gut also tells me he's going to come back and be just as good if not better than he was prior to the surgery.''
What is encouraging for Manning as he awaits regeneration of nerves in his right triceps muscle is that Weinke overcame full regeneration of nerves in his throwing arm.
Weinke's throwing arm went dead after he was blasted by then-Virginia defensive end Patrick Kearney during a November, 1998 game.
"I lost everything, full atrophy in my throwing arm, the nerves that control my right arm were damaged,'' the former Seminoles quarterback said. "My head was awkward and I got involved in a head-on collision.
"I had total nerve regeneration. So I had to in essence re-teach myself to throw.''
Weinke believes that if the Colts are indeed starting over that the Miami Dolphins would seem the ideal frontrunner for Manning's services when his slow-to-heal nerves do regenerate.
"From the outside looking in, I can tell you Peyton's one of a kind, he's going to do all the due diligence to make sure he goes to the right situation. Miami would probably be the frontrunner but who knows what a team is thinking,'' Weinke said.
Weinke won the 2000 Heisman Trophy, at 28, the oldest player ever to win college football's most coveted award and went on to make 15 NFL starts with the Carolina Panthers and San Francisco 49ers before hanging up his cleats after the 2007 season.
Last summer during the lockout, he helped prepare rookie quarterbacks Cam Newton and Christian Ponder for their initial seasons.
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


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Modification To Plugin
Hey guys. Great work on the plugin.
I am interested in SLIGHTLY modifying the plugin.
I would love it to work EXACTLY the way it does and add a parameter to the LONG URL before shortening at YoURLs.
Could you possibly point me to the place within the code that I might make that happen?
Thanks in advance for your help.
- The topic 'Modification To Plugin' is closed to new replies.


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Today, we had some family over. A nasty need to wank seized me when I saw her: my 17-year-old cousin. I went to my parents' unoccupied bedroom. My sister's baby walkie-talkie was switched on, and the whole family heard me. FML
I'm depressed, have been for awhile. I'm a dude stuck in a chicks body. I only have one friend. No hobbies and I want to die often but my best friend keeps me alive somehow. I love him to death and I know no one will read this or care but he's my whole world. I enjoy Technical theatre. There's no point in caring about your earthly belongings because you can't take them with you when you die. Some fun Quotes "Go and write that on your lunch box"
BeginnerYou have looked through 5 pages of the website. That's a start.
SocialiteYou used FML's private messaging service for the first time. Will they reply? Wait and see…
MobilityYou are connected to FML via the mobile site or an app. How modern.
The rules are the rulesReading the comment rules is a really good idea. This badge is sponsored by Alan, our moderator.
Work is a 4-letter wordVoting on an FML in the "Work" category on a Monday morning between 8 and 9 a.m. How ironic.
I'm your new creative directorYou had to give your opinion on this new "piece" that the whole world is talking about.
The thumb strikes backYou have left your thumbprint on 2500 comments.
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Keen reader – Level: student ninjaYou have voted for 15% of the entire collection of FMLs to date.
Keen reader – Level: master ninjaYou have voted for 50% of the entire collection of FMLs to date.
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42See, son, moderating FMLs is like a marathon.
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By VIVI / Saturday 25 October 2008 16:55 /
Today, was my first day as a male cheerleader in an attempt to flirt. The girls were stronger than me and it's now my job to be thrown in the air by girls. FML
By give me an F / Sunday 5 January 2014 16:16 / United Kingdom - Corby
Today, as I was driving back home from my grandma's, I looked over at the guy in the lane beside me, only to witness him with a sandwich between his teeth and his cock in his free hand. Now I know why I don't leave the city, or even drive, more often. FML
By NNTA - / Thursday 26 December 2013 23:21 / Netherlands - Maastricht
Today, for my 18th birthday my mum gave me a black lace thong. I'm a guy. FML
By Anonymous - / Sunday 15 December 2013 00:48 / Canada
Today, I was searched and questioned at the airport for having an apple. FML
By Anonymous - / Wednesday 27 November 2013 02:39 / United States - Bakersfield


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This brand new clip that supports the 'American Idol' alum's third single off 'Stronger' puts people with drug addiction, unemployment, weight issues and marital problems under the spotlight.
Kelly Clarkson has just released a new music video for her latest single, "Dark Side". Filmed in Los Angeles, the nearly four-minute clip sees the first winner singing about hope and acceptance as scenes of people enduring hard times and struggling with problems in their lives intercept.
Highlighting several portraits of human life, the video features a man who has just lost his job, a girl who is struggling with her body image and a former beauty queen who is addicted to pills among others. The mood shifts when it comes closer to an end. The sun rises and sadness turns into smiles as Clarkson belts, "Don't run away, don't run away, just tell me that you will stay."
"Dark Side" is the third single off Clarkson's fifth studio album, "Stronger", following the release of "Mr. Know It All" and "Stronger (What Doesn't Kill You)". It has been performed live by the "Duets" mentor at the 2012 Billboard Music Awards as well as this season's finale of "Dancing with the Stars".
Kelly Clarkson's "Dark Side" Music Video


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Kumar Sangakkara starred with the bat as Sri Lanka won the second one-day international against Bangladesh by 61 runs in Dhaka to take an unassailable 2-0 series lead.
Sangakkara (128) scored his 17th ODI century and shared in a crucial 114-run stand with Ashan Priyanjan (60) that helped Sri Lanka recover from 63 for three to reach 289 for six off their 50 overs.
And that proved to be well beyond Bangladesh, who despite a fine knock of 79 from captain Mushfiqur Rahim, were bowled out for 228.
Lasith Malinga, Sachithra Senanayake, Thisara Perera and Ajantha Mendis picked up two wickets apiece for Sri Lanka as they wrapped up the win with seven overs to go.
After winning the toss and opting to bat first at the Shere Bangla National Stadium, Sri Lanka found themselves in some difficulty as Kusal Perera, Tillakaratne Dilshan and Dinesh Chandimal all failed to reach double figures.
However, Sangakkara and Priyanjan helped the tourists recover before captain Angelo Mathews added some late momentum with an unbeaten 56 off 39 balls, including the only six of the Sri Lanka innings.
Priyanjan scored his runs off 97 balls as he collected his second half-century in his fourth ODI appearance, while Sangakkara had struck 14 fours before his superb knock was brought to an end when he was snared by Arafat Sunny in the 47th over.
That was a little too late for Bangladesh though, with Sangakkara's 83-run partnership off just 9.4 overs with Mathews ultimately pushing the game out of their reach.
The hosts then suffered a miserable start to their reply when they lost Shamsur Rahman to Malinga in the opening over, but his fellow opener Anamul Haque (42) helped them recover to 57 for one.
However, aside from Anamul and then Mushfiqur, no Bangladesh batsman could hang around long enough to cause Sri Lanka any serious problems with their third top-scorer being Shakib Al Hasan with 24.
Sri Lanka will now attempt to wrap up a 3-0 series whitewash when they play the third match in Dhaka on Saturday.


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Alexander H. Stegh, PhD
Assistant Professor - Zell Scholar
Department of Neurology
Phone: 312.503.2879
Fax: 312.503.5607
Email: email@example.com
Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
Center for Genetic Medicine, Lurie Rm. 6-109 and 6-250 (lab)
303 E. Superior Street, Chicago, IL 60611-3015
Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models. More...
Please read out latest publications, which received a lot of media attention (US News, FoxNews, Genetic Engineering & Biotechnology News, WGNTV, Chicago Tribune, Chicago Sun-Times, Chemical & Engineering News, Neurology Today, Science, Nature Medicine, Molecular Therapy)
Jensen et al. 2013: Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Sci Transl Med. 2013 Oct 30;5(209):209ra152.
See also an interview with Dr. Stegh on WGNTV.
Alexander H. Stegh. Integr Biol (Camb). 2012 Dec 17;5(1):48-65.
Toward personalized cancer nanomedicine - past, present, and future.
Dr. Stegh received the 2012 Young Investigator Award of the Alliance For Cancer Gene Therapy.
Stegh laboratory assumes leadership role in Northwestern's Center of Cancer Nanotechnology Excellence Grant (NU-CCNE U54). Read more at http://www.ccne.northwestern.edu/


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South Connellsville decides against Ten Commandments monument at honor roll
Almost a year after the ongoing controversy surrounding the Ten Commandments monument started in Connellsville, South Connellsville council made a decision about an offer to place a monument in the borough.
During Monday's regular meeting, Councilman Clyde Martz said he received communication from the Rev. Ewing Marietta, pastor of Liberty Baptist Church, about placing a Ten Commandments monument at the South Connellsville Honor Roll.
Marietta is also an organizer of Thou Shall Not Move, a group that was formed after a legal battle over a Ten Commandments monument at Connellsville Junior High School. The monument has been at the school for more than 50 years.
In 2012, an anonymous student and parent, along with the Freedom From Religion Foundation, filed a lawsuit, which seeks the removal of the monument from school district property. The district is fighting its removal.
Thou Shall Not Move has raised money to help fight the legal battle and to place monuments in front of different locations in the area.
South Connellsville had to vote on placing a monument at the honor roll, a borough-owned property.
"We were advised by our solicitor to definitely not do that," Martz said, adding the advice came from the fact that the issue has not been resolved with the school district in their ongoing legal battle and it would mostly likely end with a lawsuit against the borough. "That will put the borough in risk that we don't need at this time."
Council unanimously voted against placing the monument at the honor roll. Council President Mark Ward did not attend Monday's meeting.
"I don't want to see them put one up there and then have it boarded up," Martz said.
Councilman Guy Napolillo said the whole situation was "a sad state of affairs."
However, council asked Don Ringer, president of South Connellsville Volunteer Fire Department, if it would consider having a Ten Commandments monument in front of the fire hall, since the monument would be seen by more people at that location.
Ringer said he was never approached by anyone about placing a monument there, but it would be considered.
In other business:
• Resident and South Connellsville VFD Chief Steve Helms again approached council about the alley behind his house along Painter Street where he said vehicles drive through at speeds between 45 to 50 mph.
He said his four children are getting older and if they would happen to be playing outside and a ball goes out onto that alley and they go out there, they wouldn't stand a chance.
Martz said they will look into placing both speed bumps and a stop sign in the alley.
• Another resident had concerns about a quad speeding through an alley behind First Street and that has been going up and down the alley four nights in a row, including before Monday's meeting.
• Napolillo reminded residents with flood damage that Sept. 16 is the last day to apply for a disaster loan through the Small Business Administration. FEMA rejected the borough's request for funds after heavy rains caused significant damage to residents in July. Those interested may call 800-659-2955, email firstname.lastname@example.com or visit the website at www.sba.gov
• Council announced a car show on Oct. 12; tar and chipping to start on either Friday or Monday; fall cleanup on Oct. 9; and Community Yard Sale on Oct. 5.
Mark Hofmann is a staff writer with Trib Total Media. He can be reached at 724-626-3539 or email@example.com.


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Morris Publishing Announces Agreement with Committee of Bondholders
Morris Publishing Announces Agreement with Committee of Bondholders
AUGUSTA, GA — September 25, 2009 — Morris Publishing Group, LLC announced today that it has agreed to the terms of a restructuring agreement with the holders of over seventy-five percent of its outstanding senior subordinated notes. If the restructuring is approved, the holders of the $278.5 million in outstanding notes would exchange their existing notes for $100 million of new second lien secured notes. At that time, affiliates of Morris Publishing would make capital contributions and repay indebtedness to Morris Publishing in order to cancel $110 million of its $138.75 million in existing senior secured indebtedness. The restructuring agreement is subject to the final negotiation and execution of the definitive legal documentation and other closing conditions.
In addition, Morris Publishing has obtained an extension until October 16, 2009 to make two semi-annual interest payments of $9.7 million on its senior subordinated notes originally due Feb. 1, 2009 and August 3, 2009. The holders of more than 80 percent of the outstanding amount of senior subordinated notes have agreed to extend the forbearance period for these payments.
Morris Publishing's senior bank group also agreed to extend until October 2, 2009 the waiver of the cross defaults arising from the overdue interest payments on the senior subordinated notes.
About Morris Publishing
Morris Publishing Group, LLC is a privately held media company based in Augusta, Ga. Morris Publishing currently owns and operates 13 daily newspapers as well as nondaily newspapers, city magazines and free community publications in the Southeast, Midwest, Southwest and Alaska. For more information, visit our website, morris.com.
For Further information, please contact:
Craig Mitchell
Senior Vice President of Finance
Morris Communications Company, LLC


text: On Tue, Jul 01, 2008 at 02:47:12PM -0700, Robert Kaye wrote: > > Yes, it's always interesting to hear performance reports. > > Ok, I've tinkered with the setup a bit. I've found that if I give > xapian loads and loads of RAM, it doesn't even get around to using all > the RAM I give it -- at most each process used 5% of 8G of RAM. > > I measured disk access with: > > iostat -x 10 (10 second disk usage average window) > > And CPU util with top. I've found: > > 3 processes: 95% - 96% CPU usage for each process, 40%-60% disk usage > 4 processes: 95% - 96% CPU usage for each process, 60%-90% disk usage > 5 processes: 92% - 94% CPU usage for each process, 80%-100% disk usage > 6 processes: 91% - 93% CPU usage for each process, 100% disk usage > sustained > > It looks like 4 processes is the sweet spot that doesn't utterly slam > the machine. This is much better than I had anticipated -- well done > Xapian team! Couple of detail questions: * what processor? * what OS? * how many spindles behind the FS volume? * what hard disks? All hard data is good data, but obviously it's even better if there's context as well -- apologies if you're already given any of these details, but I didn't notice them recently in the thread. (By the way, slamming the disks during index is what you want to do unless you're also searching off the same database. A breakdown of the type of CPU usage will help analysis here -- iowait versus sys/user will tell you when you're starting to become IO bound. 4-6 processes to max out your storage is pretty good :-) J -- /--------------------------------------------------------------------------\ James Aylett xapian.org james at tartarus.org uncertaintydivision.org


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Aveda Rosemary Mint Conditioner8.5 ounces | Conditioner, Daily Conditioner
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This daily conditioner adds weightless body and shine while preventing tangles and static. The tonic properties of rosemary and peppermint cool and revitalize your scalp.
aqueous extracts of organic rosemary and peppermint, polyquaternium-11 (conditioning agent), cetyl alcohol (coconut), glyceryl stearate (coconut), stearalkonium chloride (mixed plant oils), vinegar (grain), olealkonium chloride (mixed plant), aveda's own pure, natural preservative fragrance containing: peppermint, geranium and many other pure flower and plant essences, tocopherol (vitamin e, antioxidant), jojoba oil, oryzanol (natural sun filter), glycerin (coconut), hydrolyzed hair keratin (human hair protein), grapefruit seed extract, diazolidinyl urea (preservative)
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