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Recreation and Leisure
Jules Obtains the Jewels
Sean North
Jules Asner, the current cohost of E! News Daily, along with Steve Kmetko, had a golden opportunity to be the first one to host E!'s "Wild On" adventure series. The series was originally titled "Sex on the Riviera." When Eleanor Mondale left the show, Jules filled in and ended up hosting "Wild On" for a year and a half. The "Wild On" series takes viewers around the world and shows them that there are OTHER extremely wild people besides Americans doing extremely wild stuff. Yes, Brooke Burke DID have a predecessor. Although in an interview, Jules mentioned that she was reluctant to host the "Wild On" adventure series. She wasn't sure if she wanted to put herself through the dangerous demands of para-sailing, for instance. By the way, her para-sailing adventure was one of her scariest moments. Apparently, Jules was terrified, and rightly so, when the wind kicked up more than usual and Jules was drifting in the air more than what was planned. It also didn't help matters that the producers took their time bringing her down. Physically, she ended up fine, but her anxiety was obvious because of the expletives were bleeped out and by watching what she was experiencing.
Jules hosting the "Wild On" series was an invaluable link to her current endeavors. She currently cohosts E! News Daily with Steve Kmetko, which she initially and ultimately wanted to do. Along with E! News Daily, she hosts her own show, "Revealed." Will ANY of our link positions (or stepping stone) positions likely to be as exciting, glamorous or as famous as the E! "Wild On" show? Certainly not! But the point is that Jules was initially reluctant to host "Wild On." How many positions have we turned down because we've been initially reluctant to take a job that we KNOW will lead to a career? As a former fast food manager, I KNEW that I was grossly underpaid, and the stress level for what little I was paid was robbery. I KNEW that I could always say that I had management experience whenever I did a resume or filled out an employment application.
How many of you have that feeling of "what's the use?" when you were wishing that you could be doing something better? You CAN do something better! Yes. It DOES take an investment in time. There are so MANY companies that need talents YOU have to offer. Everyone has some talent that is valuable to an organization. There are many great websites that offer skills assessment testing. The tests are invaluable for that kind of determination that asks what kind of a career you are suited for. Too many of us settle because I have been one who has settled in the past. I am taking steps to attain my dream career. What you do with YOUR talent is up to you.
Article Source:
Sean North primarily helps writers gain focus, motivation, remove mental blocks that help to unblock the writing process.
EVERYONE who writes has been stuck at some point in his or her career. You do not have to accept these mind-boggling roadblocks!
(586) 216-7516
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Carey Hart of Hart & Huntington Tattoo Company
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Flowers Can Make Your Parties Better Than Paris Hilton's
Jules Obtains the Jewels
Psychic Jane Doherty: How she became a Psychic Ghost Hunter
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Spring transformation challenge
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Who is ready for a transformation challenge? Starting April 1st I will be putting on a transformation challenge. The cost will be $490 per group
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There will be groups of 3 people. You can put together your own group of people that you can help push, motivate and support. Everyone will have access to all the food logging, exercise tools and resources, meals plans and me as their online trainer to successfully transform their body! We will go for a total of 12-weeks and the group with the highest percentage of weight loss will be rewarded!
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The hospital currently employs approximately 3,200 staff in a variety of roles. These include:
|Technical & Scientific
|Nursing & Midwifery
|Allied Health
|Support Staff
Each year the hospital participates in a number of graduate and traineeship programs. In the area of medicine these include internships and registrar places in a range of specialty areas while the Graduate Nurse Program is designed to assist nursing students to make the transition between study and work in an acute care setting. The Allied Health Division also employ new graduates in speech pathology and podiatry.
Flinders Medical Centre recruits graduates accepted into the South Australian Public Sector Graduate Program in areas such as accounting, business studies and management. Traineeships that are part of the South Australian and Commonwealth Governments' commitment to assisting young job seekers to enter the labour market, are also offered in job categories such as information technology, clerical and technical.
A range of work experience places for senior secondary or tertiary students is also available on application.
Over the next two years Flinders Medical Centre aims to become an 'employer of choice' by improving incentives, career opportunities and job satisfaction for staff. This will increase our chances of attracting, recruiting and retaining highly capable people in areas where skills are in short supply.
These professional and non-professional areas include:
Flinders Medical Centre offers a range of employment options including permanent positions, short and long term contracts and casual work. It is also possible to work part time or job share in some positions and a range of other 'family friendly' work initiatives will become available during the next 12 months.
On site facilities include a 60 place childcare centre catering for FMC and Flinders University staff and the general community. Set on large natural grounds the centre is open 6.30 am – 6.00 pm Monday to Friday. For further details please contact the director on telephone (08) 8204 5306.
While some positions must be advertised to public sector employees in the first instance, many others are recruited through external advertising in state and national newspapers, journals and professional bulletins. Enquiries are always welcome.
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One of the most important factors influencing the perspective of both parties in negotiation is where they sit; that is, what their area of responsibility is.
If I am responsible for cutting costs on a project, and your idea, good as it is, increases costs, then I am likely to resist your idea. Our feelings about the issue in dispute affect how we perceive the opposer's proposal or idea.
If I have seen an idea like the one you are favoring fail in the past, then I will be skeptical that yours could succeed. If, however, I perceive you to be a highly competent professional, then I might give your approach the benefit of the doubt.
Our personal motivations, concerns and ambitions also condition our responses to and acceptance of whatever is offered or set forth. If I believe that what you say will help my career, I will lean toward it. If it jeopardizes my job, I want no part of it.
If we both enjoy the same communication and information channels, we are likely to hold similar viewpoints. The same is true if we share a common cultural background and beliefs.
It is obvious that these factors play a role in exacerbating or narrowing differences at work. The best way to reach agreement is to give thought on these driving forces when differences arise and to speculate how they may be affecting the issues under consideration.
The worst approach is to stigmatize the other party and close your mind to their point of view and driving forces. Yet that is exactly what so many of us do when differences with others happen.
Thanks for visiting! If you enjoyed this post, you can learn many more useful negotiation tips through our free download of Negotiating Tips.


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Discussion in 'Fan Zone' started by houstonwhodat, Dec 19, 2012.
Texans SUCK!
No it isn't
Simply case of _____ envy. Apparently a word I can't say.
That will be nice for their fans to watch the first round bow out on.
...and it doesn't get hit by a punt.
I won't be shocked if Denver is the team. Von Miller on one side of the ball and Peyton Manning on the other just seems to be a loaded deck for them right now.
I read that the purpose of their new video boards will be mostly for advertisements.
Houston is not a team that is on my radar. They aren't even in the NFC, but their fans are rabid Dallas haters. I didn't realize how much until I started reading it on the internet. I really don't get it? I could understand if the Cowboys were their division rivals?
The comments on that site are pathetic. We are on their mind constantly.
So much false is there I live in Houston and you talk about the Headcoach who the fans wanted run out of town after season 4 and all through season 5. In fact the fan base was pissed at the start of season 6 when they broguht Kubiak back; but that died down after they made their first playoff. Do you think Kubiak would get 6 years in Dallas to turn around a team .
The GM was picked by the coach not the owner he was a guy that was never a GM before and came from Denver which Gary had ties with.
Then you talk about the team the ones that have busted on many first round picks and 2nd round picks and had to spend like a drunken sailor to fix the secondary because they failed in the draft.
A team that has lost some talent due to salary cap hell and let guys like Winston walk.
Please they are playing while right now but they are not on the way up they have about a 2-3 year window and then it will come crashing down.
The ones at Lowes Motor Speedway are probably still the largest, overall, in all of "sports". Not the widest any longer I guess but they eclipsed Cowboys Stadium last year I remember.
And next year another team will plan for a better board than the Houston one & so forth.
By the time a team gets the "best" board the new best is already in the works.
Yet here you are ....... on a Cowboys board that you joined 2 years ago ...... crying like a little *******
:laugh2: :laugh2:
Really the texans don't care about the Cowboys? Your entire IDENTITY is based around us. Inflammatory t-shirts, jabs in local commercials, open media hate etc etc etc
You have no identity of your own and so you grasp onto whatever teams you can to formulate your own - from your uniforms, to your stadium toys, to your themes.
Here's an idea:
I must've been asleep the past few weeks. When u got ur *** handed to u by one Tom Brady and Dallas has won 5 outta 6 with a busted online and defense. Dallas fans outside of Houston don't know u exist. So y don't u worry about teams in ur own conference/division and leave ur insecurity/inferiority-based hatred of Dallas out of it. Any of on here could give less of a crap if u have the biggest video monitor or seats of gold in reliant. So move on, sir, nothing to see here.
For the rest of you lads and lasses, here's some trash from Facebook.... Enjoy lol!
Twas the month before Playoffs when all thru the NFL:
Dallas Fans were pouting cuz their team played liked hell
Their beer was all packed in coolers of Ice
In hopes before each game the football Gods would be nice
I in my "WATT" jersey, just stood there and smiled
Feeling "kinda" bad that their team ain't won in awhile
I knew they kept stats but just outta fun
I reminded them the TEXANS are 12-2
They started cursing and yelling and throwing their beer
When what to their wandering eyes did appear?
A jolly ole man with a head full of grey sitting on a red white and blue sleigh
With 9 Giant Toros leading his way
They knew he looked familiar ,but at first they could not tell
Then they realized it was WADE PHILLIPS...then they thought.. OH HELL..
his voice was loud, His eyes full of gleem
so PROUD HE WAS TO FINALLY COACH A GOOD TEAM
He screamed at his Toros, like a man full of Pride
and he sat back and smiled and enjoyed his ride
ON Smith,On Barwin, On Joseph and Quin,
Im proud to finally Coach a group full of Men
Come Manning Come Cushing Come Mericulus & WATT Lets Finally show TEXAS the team that we got
In the Corner of my eye I seen from afar
What appeared to be a silver and blue shining star
Then the sleigh with the mighty Toros passed by its side
They each hiked their legs and Peed with such pride
I heard them exclaim as they drove out of sight
BAWAHAHHAHAHAHHAHAHA — with Xxxxx and 7 others.
Should I even bother to reply?
That Texans fan got owned twice.
he can take it, he's a bigboy
I think it was their letterman jackets that did them in regarding the NE game.
Glad they have a good team. I don't think anyone should overlook they are a team on the rise.
Their fans do get their panties in a wad over the Cowboys. That is a fact. To say otherwise IS A LIE.
Of course Cowboys fans still brag about their past. Just like any other team fans do. You're always proud of championship teams & great players. Always.
I wouldn't brag about winning that pansy AFC South division last year(or this year),,, lol
so mad
It's true. The Cowboys last Super Bowl win was 17 years ago.
Hey, just out of curiosity, when was the Texans last Super Bowl win?


text:
Have Jeep Questions? Ask a Jeep Repair Expert for Answers
Hello and welcome to just answer. This model of Jeep used the Ford Motocraft electronic ignition module, and I have seen these modules fail and cause this stalling/dieing problem. Usually replacing the module will take care of this. So I would start there. There may also be a recall on your Jeep that may be related to your problem. here is a link to that information. This may apply to your Jeep, but check with the Jeep dealer first. Hope this helps,


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Ah the echoes of my old papery life keep rustling around me. I'm writing a feature for ICIS Chemical Business on Second Generation Biofuels.
I've just asked Air Liquide for more details on Bioliq a process developed by its subsidiary Lurgi which converts straw to liquid, and then converts that to synthesis gas and on to liquid fuels.
Here are some of the questions that I've just asked the press office.
- How is the syn crude made?
- Is it a biological process
- If so is it bacteria driven/mould/enzyme driven or some other route (as much detail as possible please) What is the yield and the rate of the process?
- Is it a chemical process. How is it catalysed (as much detail as possible please) what is the yield and the rate of the process ?
- Refining the biocrude sounds very much like Fischer-Tropshe is that the case what kind of catalysts are you using. What is the yield and the rate. ?
- How much gasoline can you generate from a tonne of straw?
- What is the energy balance of the process. How does it compare with ethanol fermentation/crude processing.
- What distance do you think that you'll need to take straw from to meet demand. At what distance is it uneconomical?
- Does the process regenerate carbon that could be added to the soil to stop it becoming depleted.
I wouldreally appreciate as much data on these points as you can manage by Mondayafternoon (9 Feb 2009). Please let me know if this is going to be possible.
Best wishes


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From The Atlantic
The challenges of surveying an intricate land mass that's losing 16 square miles a year.
While the storm only forced some of us from our homes, it cost us all a way of life.
The survey will kickoff the most revolutionary American mapping project in a century.


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Jimmie Dale O'Steen
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Aug. 21, 1934
Marshall County
Oklahoma, USA
Jan. 1, 2013
Bryan County
Oklahoma, USA
Jimmie Dale O'Steen
August 21, 1934 - January 1, 2013
Jimmie "Dale" O'Steen, retired educator of Durant, passed away Tuesday, January 1, 2013, at the age of 78.
He was born in Willis, Oklahoma, on August 21, 1934, to parents Chester Lewis and Carrie Belle (Jackson) O'Steen
Jim grew up in Marshall County, Oklahoma, and graduated from Russett High School. After graduation, Jim worked as a truck driver for Clint Williams. In July, 1954 he entered the U.S. Army and served in the Korean War. Jim was awarded the National Service Defense Medal & Good Conduct Medal.
Jim attended Southeastern Oklahoma State University where he received a Bachelor's Degree in Mathematics. In 1964, he achieved a Master's Degree from the University of Missouri. From 1971-1973 Jim worked on his Doctorate in Computer Science at the University of Oklahoma.
Jim married Karen Maxine Jones, on June 2, 1964, in McAlester, Oklahoma.
Following their marriage, Jim was hired by IBM in Huntsville, Alabama to work as a prime team member in the Manned Flight Awareness Program. His engineering team developed an IU component for the Saturn /Apollo Spaceship. In 1967, Jim moved his family to Durant, Oklahoma, and brought with him the knowledge to head the first Computer Science Department at SOSU. He also developed, and installed the program that led to the university's original computerized enrollment. Jim retired from Southeastern in 1995, with 28 years of service.
In his retirement Jim enjoyed spending time with his family and especially attending his grandkids activities. He liked tending to his garden every summer, yard work and woodworking.
Jim was a member of Tau Kappa Epsilon Fraternity, Blue Key, Kappa Delta Pi, a volunteer youth baseball and basketball coach, Boy Scout Cub Master and Durant Athletic Club Treasurer. He has been an active member at Northwest Church of Christ for many years serving as coordinator of the Feeders Program. He volunteered for RSVP where he assisted with Meals on Wheels and their blood drives. Jim was an officer for the Oklahoma Retired Teachers Association.
Jim is survived by his wife, Karen O'Steen of the home; son Jerry Dale and daughter-in-law Ashley of Shawnee, Oklahoma; son Stephen Wayne and daughter-in-law Barbara of Durant, Oklahoma; son Mark Lee and daughter-in-law Laura of Lino Lakes, Minnesota; 9 grandchildren Tina O'Steen Thorne and husband Jared of Durant, Katy O'Steen of Edmond, Hazel Knudson of Lino Lakes, Minnesota, Shelby O'Steen of Shawnee, Carter Knudson of Lino Lakes, Minnesota, Casey O'Steen of Durant, Connley O'Steen of Shawnee, and twins Ashlyn and Eva O'Steen of Lino Lakes, Minnesota; 1 great granddaughter Kenidee Thorne of Durant.
He was preceded in death by his parents, 6 brothers, 4 sisters and several nieces and nephews.
Services are planned for 1 p.m. Saturday, January 5, 2013 at Northwest Church of Christ in Durant, Oklahoma, with burial at Lark Cemetery. John Carrell and Don Gelles will officiate, with congregational singing led by Rudy Manley.
Casket Bearers will be nephews.
Condolences may be sent to the family at www.brownsfuneralservice.com.
Services under the direction of Brown's Funeral Service
Family links:
Chester Louis O'Steen (1882 - 1941)
Carrie Bell
O'Steen (1895 - 1969)
Robert William O'Steen (1913 - 1983)
George Louis O'Steen (1919 - 1977)
Jimmie Dale O'Steen (1934 - 2013)
Baby Boy O'Steen (1938 - 1938)
Baby Twin Girl O'Steen (1940 - 1940)
Baby Twin Girl O'Steen (1940 - 1940)
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Katie was knowledgeable about all aspects of what would be needed for the project. She was patient, and offered a no-pressure opportunity for me to make as many changes as Needed until I was totally happy.
Posted on GuildQuality: 7/08/2017
The Company came for an evaluation, offered imformation and soloutions. We agreed on the project, they came when they said they would, were professional and cleaned up after each day. I am totally HAPPY!
Posted on GuildQuality: 6/24/2017
everyone involved at Exovations with our project was extremely professional and addressed questions or needs directly and immediately. will certainly use them with future projects.
Posted on GuildQuality: 6/22/2017
I was completely satisfied with everything... I have no complaints. Exovations replaced my old wood siding with James Hardy, replaced all my gutters and added an extra downspout where it was needed, installed new and more modern looking posts at my front door, and installed my new light fixtures. I'm probably forgetting some things, but I can truly say they truly did a stellar job! Thanks to Exovations, my house is the prettiest one in the neighborhood. Too bad they don't do landscaping because I could really use a miracle with that!!! ;-)
Posted on GuildQuality: 6/18/2017
We had Exovations replace 2 windows 10 years ago and we were very pleased. So when we needed to replace 2 doors and a picture window, we called then to give us a quote. The salesperson, the PM and the installers were very professional and Exovations does an excellent job of keeping you informed through their website. Without question, I would recommend Exovations to anyone wanting a successful project.
Posted on GuildQuality: 6/08/2017
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I have used Exovations for roof, gutters, windows. Each and every project has gone extremely well. I would highly recommend them. Their prices are fair and their employees are great. I would not use any other company for projects.
Posted on GuildQuality: 6/01/2017
The Vinyl Siding installation was extremely poor. It was truly a bait and switch tactic.Their website says they offer stress free remodeling.This is the worse job I've ever had done on my home. There are a significant amount of buckles and I was told my house was buckled.This was discussed throughout the entire installation and it still hasn't been fixed. I was even told by the project manager I was assigned that it is not the worst job they have done. The total cost of my project was almost 30,000 and to me the siding installers was day laborers and that was not my expectation. I could have hired day laborers myself and spent a whole lot less money. I would highly recommend using a different company.
Posted on GuildQuality: 5/30/2017
Exovations was knowledgeable about the difficulties of working with the city of Atlanta and securing a permit. The months of bureaucratic-generated delays was frustrating but Exovations continued to provide updates on the status of the project. The original estimate was fairly close to the finished cost, and was competitive for the area. Green Sky is available for financing and was a pretty seamless process. Crew was professional and efficient. Construction seems solid and we are pleased with the final results.
Posted on GuildQuality: 5/28/2017
Another satisfied customer. The Sales rep, Tom, was very detailed in pointing out the repairs I needed for the job to replace all siding and paint entire house. He provided me with a detailed, easily understood, line itemed quote. Kent Lang, the project manager took over after that and was a pleasure to deal with. Very responsive. Crews did excellent work and I could not be happier with the finished product.
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Very pleased with the quality of work we received. We've already decided that our next project -- design work being already underway -- will be handled by Exovations.
Exovations handled all of the exterior renovations we needed from start to finish, ensuring that all of the work was done in the proper order. Also, I had no concerns about different contractors getting confused about who was handling what part of the job (since there is often overlap) and I know that there will only be one person to call if there are ever issues in the future. I would definitely recommend them to anyone who wants peace of mind that the project will be done right without the customer having to monitor every aspect of the work.
Excellent, very qualified crews that worked quickly and to our standard. Cleaned up every day even mid-job, and protected our landscape very well.
Posted on GuildQuality: 5/02/2017
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If your window breaks in the middle of a storm, you know that you need a window replacement in Atlanta in order to protect your home. However, most people don't take the same immediate action when their siding needs repair. It's important to repair...READ MORE »
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If your window breaks in the middle of a storm, you know that you need a window replacement in Atlanta in order to protect your home. However, most people don't take the same immediate action when their siding needs repair. It's important to repair or replace damaged siding as soon as possible for the following reasons.Read more »


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About the Book
More than 7 years of travelling across Latin America doing several reportages for megazines and international agencies, Italian photopgrapher based in Chile, Lorenzo Moscia, show a sort of "greatest hits" of same of his long-term projects.
From Easter Island to Haiti, and also Japan and Africa, are now presented in a very intimate way. Moscia almost never uses a long focal lenses, he prefers instead very shorts ones (28mm, 35mm) he is always very close to the scene, and creates a relationship with his subjects. You cannot be indifferent to his works. To have a vew please vsit: www.moscia.cl
Features & Details
- Category Fine Art Photography
Small Square, 7×7 in, 18×18 cm
214 Pages
- Publish Date May 21, 2008
- Tags Easter Island, Latin America, Chile, Brazil, Africa, Cuba, Ecuador, Japan, Reportages, photographer
About the Creator
LORENZO MOSCIA 6-9-1973, Rome Italy, italian nationality, chilenaean citizen www.moscia.cl 1999 Law degree in the University of Rome. PHOTOGRAPHY AWARDS: 2008 1st place photojournalist award of Chile (daily laife.reportage) 2008 1st place INSTITUTO INTERAMERICANO DERCHOS HUMANOS award http://www.iidh.ed.cr/ 2006, first place with the documentary "Luci di Rapa Nui" Chatwin Prize, Genova Italy 2005.first place in the press category for the reportage "Prostests in Lota, south Chili" www.fotopresna.cl 2004- 1st place photojournalist award of Chile (www.fotoprensa.cl, nature category) -second place in the category "reportage" for the photojournalist award of Chile -therd place in the category "portrait" for the photojournalist awards of Chile 2004 - One of the finalist in the National Geographic Award in the profesional category. 2004- finalist of the Humanity photo awards in China. 2002- 1st place in the United Nation contest "Ojo con Chile" 1998- 2nd place in the univarsity of
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|Home > Entertainment > TV & Radio > Article
Even after Christina's preferences were revealed to her, Stapleton was less concerned about her character's sexual orientation than with the possibility it would be explored in a cliched manner.
"I didn't want to be seen as a stereotype. I've always been a bit apprehensive about exploring issues of sexuality on television," Stapleton says. "But I think it's been done in a very real way."
Viewers will have several opportunities in the weeks and months ahead to judge the series's treatment of Christina's sexuality. It comes into focus in this week's temperature-raising episode when she gets hot and bothered with a female target, then later with the arrival of Constable Leo Flynn, played by Daniel Frederiksen.
Christina's lust has prompted some complaints from viewers, but Stapleton is unfazed. "One woman wrote in to say she won't watch another episode because I kissed a girl, but you lose one viewer, you probably gain a lot more.
"They're contemporary stories we are exploring, and it is part of who she is."
Christina Dichiera, says Stapleton, is 21 and searching for herself, escaping a troubled childhood, drugs and life on the street. "The core of the character is she's confused, she's been in so many different places to find out who she really is. She's out there, free, she goes with what she wants to do at any particular moment."
Although viewers may search for parallels between Stapleton and her character, she is quick to point out the differences between them.
"She's a lot tougher, she's in situations that I will never be put in. I can be quite feminine and girly, and she's not really like that."
Stapleton, however, has had some experience of roles that mirror her life. When she was eight, she played a child who observes her parents' painful divorce in the feature film Boulevard of Broken Dreams.
"I did Boulevard while my parents were divorcing. Now I know it's called emotional memory, or memory recall, but it helps if there are those memories. Sulli (actor Sullivan Stapleton is her brother) and I both have them."
Her early initiation to acting came almost by chance. An aunt got her children into an agency and told Stapleton's mother, a nurse, that the agency was looking for blond, blue-eyed kids.
"She asked us and we said yes. That's it. It's bizarre. Imagine if she hadn't asked. What would we be doing?"
She estimates she has done between 50 and 60 commercials and some modelling work, which she swore off doing when she was 12. Her epiphany came at the end of a cattle-call casting session, when she was told in front of the two successful applicants that she could leave.
"I felt hurt, disappointed, a failure. And I realised it was on account of something I couldn't change and that was the way I look. So I decided not to do that any more."
Her acting ambitions were set when she landed the lead role in a play at Sandringham Secondary College ("Sandi was like art school," she recalls). "It was then I realised I wanted to do this for the rest of my life. I thought, 'That's it, it's my choice'. That's when I realised I could, and would, do it.
"I remember sitting in that drama room and reading the script. I understood it," she recalls with joyful enthusiasm, before exploding into a conspiratorial laugh. "You are trying to make me blow my own trumpet, and I'm not going to do it!"
She admits she felt some trepidation committing to the Stingers role.
"I had been out of work for a little while and was at that age where I was trying to find myself and exactly what I wanted to do. It wasn't my ideal to get into a contract on another television show.
"But it felt so right. I got the script and I knew what I had to do."
Stapleton makes no secret of her ambition, having taken herself twice to Los Angeles for auditions and training. The attractions of working overseas, she says, are money and the range of bigger-budget projects and talent.
And though she regrets missing two roles - the lead in a television version of Legally Blonde and a new version of Firestarter - she has few misgivings. "You go into auditions and there are clones of you. There will be 20 people that look exactly the same. It's bizarre."
Being contracted to Stingers for two seasons is a salutary experience for the confessed actor-in-a-hurry. "I'm driven, impatient and am afraid of failing. It comes from starting early and knowing from a young age that I wanted to do this."
Stingers screens on Tuesdays at 9.30pm on Channel Nine.
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Uttal T., A. Makshtas and T. Laurila (January 2013): The Tiksi International Hydrometeorological Observatory - An Arctic members Partnership. WMO Bull., 62 (1), 22-26.Full text not available from this repository.
The global community has recognized over the last few years the importance of the weather and climate of the Earth's Polar Regions.Particularly sensitive to human activities, the Polar Regions have also demonstrated the potential for impacting reciprocally on the livability of the more heavily populated lower and mid-latitudes. In response, the WMO Polar Observations, Research and Services (PORS) was developed to "…promote and coordinate relevant programmes that are carried out in the Antarctic and Arctic regions by nations and by groups of nations." The Polar Activities resolution of the WMO Executive Council Panel of Experts on Polar Observations, Research and Services also encourages "Members, particularly those that have operational activities in Polar Regions, to consider the possibility of cooperating with other Members in sharing the costs of re-opening and operating previously functioning stations, in expanding existing stations or in deploying new observing and communication systems." The Tiksi International Hydrometeorological Observatory in the Russian North on the shore of the Laptev Sea is a unique example of the kind of multi-national effort that is recommended by the Polar Activities resolution. The impetus for the Tiksi Observatory planning, which preceded the resolution, was the International Polar Year – actually a two-year period between March 2007 and March 2009. The Russian Federal Service for Hydrometeorology and Environmental Monitoring (Roshydromet) submitted a focused proposal to the International Polar Year committee entitled "Developing the Atmospheric Observatory of Climate Monitoring in Tiksi," which the committee clustered with related Arctic observatory proposals under the umbrella activity "International Arctic Systems for Observing the Atmosphere." As a result, the modernization and integration of the Tiksi Station into a pan-Arctic observing network became a priority not only for Russia but also for US and Finnish agency partners who also recognized the requirement for a broad spectrum of regionally specific Arctic observing perspectives.
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|Physical Sciences Division


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The ABCs of Buying the Perfect Gifts
It's always a challenge to find the perfect gift for that friends, family members, and co-workers, but by following these ABCs, you won't go wrong!
Choices - Sometimes, the best solution for the hard-to-buy for person is a gift certificate. Let your recipients choose the perfect gifts!
Digital Camera - If your recipient is still using a film camera or throwaway cameras, it's time to drag them into the 21st century and into the digital age!
Electronics - There are a zillion choices when it comes to personal electronics. Surely your recipient would welcome any one of a number of electronic gifts.
Flea Market - If you're shopping on a budget, a flea market can be a great place to find one-of-a-kind gifts at bargain prices.
Garments - If you know your gift recipient's sense of style, apparel is always a great gift. Whether it's a cozy sweater or a supple pair of gloves, garments are sure to be appreciated.
Handbag - There's nothing more exquisite than a wonderful purse. Depending on the recipient's taste a small clutch for the evening or a funky knapsack for daytime may be the perfect gift.
IPod - iPods can be pricey, but iPod accessories are both fun and affordable.
Jewelry - Whether she admits it or not, every woman loves jewelry. From costume pieces to precious stones, jewelry always makes for the perfect gift.
Key Chains - Key chains are just one of many kinds of gifts that can be personalized with a photo or with your recipient's name. Monogrammed and personalized gifts are always in style.
Linens - A beautiful tablecloth with matching napkins or a set of fluffy bath sheets always make a wonderful gift.
Movies - Add to your gift recipient's DVD collection by selecting movies starring his or her favorite celebrities.
Never - Never make the mistake of buying for someone else the gift that you would like to receive. Spend some time thinking about their preferences and hobbies, and you can't go wrong.
Outdoors - Many people don't purchase outdoor items for themselves, so why not do it for them? A great doormat, outdoor thermostat, or garden accessory makes a terrific gift.
Pets - Pets have feelings too, so be sure to remember them on gift giving occasions. A snazzy collar or a special bag of treats will set tails to wagging.
Query - If you can't come up with a gift idea, ask the people closest to the recipient. They're sure to offer helpful suggestions.
Ribbon - Spending a little time and creativity wrapping your gift makes it all the more special. Use raffia instead of ribbon, comic pages instead of paper, or clear cellophane to bundle your gift.
Sales - Do your gift shopping in bulk. Find online stores that have sales or everyday discounts, and save while you shop.
Telephone - Today, everyone is permanently hitched to his or her cell phone. Cell phone accessories make wonderful gifts.
Unbelievable - Some of the most unbelievable shopping bargains can be found online.
Video Game - Surely, someone on your gift list is a gamer, so why not get the video game - or gaming system - they've been longing for?
Wholesale - There's nothing wrong with buying great gifts at a bargain! Look online for opportunities to buy gifts at wholesale prices.
Xciting - Special occasions are exciting. When you show up to a celebration with your gift, make sure you also show up with a festive attitude!
Yo-Yo - Children aren't the only ones who appreciate opening a package and finding a toy inside. For adults, think retro toys that trigger childhood memories.
Zebra - Everyone has a wild side, so buy a gift that features an animal print.
To learn more about subjects like gifts please visit the web site at: http://www.bestdiscount-deals.com
For more information and informative related articles and links about this subject matter and content, please visit Majon's Gifts | Gift Ideas | Gift Shops directory: http://www.majon.com/directory/gifts-gift-ideas-gift-shops.
About the Author
+Chris Robertson is a published author of Majon International. All Rights Reserved. Copyright 2014 (Sat Jul 08 2006) Majon International. Majon International is one of the worlds MOST popular internet marketing and internet advertising companies on the web. Visit their main business resource internet marketing web site at: http://www.majon.com


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Discover a selection of top forums cherubim animeers on the internet. Come to share your passion on forums cherubim animeers and meet other fans of cherubim animeers. Then, why don't you create your own forum of cherubim animeers ?
A network for angels, archangels, to come together in the service of god. To offer teachings, guidance and inspiration to humans. To unite all angels on earth to our cause.
angel, archangel, network, archangels, there, #cherubim, gods, angels, wingate, durham


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Medications, injections, and supplements for arthritis
Ask your health care provider about medications that may help relieve your arthritis pain.
Over-the-Counter Pain Relievers
Over-the-counter pain relievers can help with your arthritis symptoms. Over-the-counter means you can buy without a prescription.
Most doctors recommend acetaminophen (such as Tylenol) first, because it has fewer side effects than other drugs. Do not take more than 4 grams (4,000 mg) on any one day.
If your pain continues, your doctor may suggest non-steroidal anti-inflammatory drugs (NSAIDs). You can buy some NSAIDs, such as ibuprofen and naproxen, without a prescription.
Taking acetaminophen or another pain pill before exercising is okay. But do not overdo the exercise because you have taken the medicine.
Both NSAIDs and acetaminophen in high doses, or taken for a long time, can cause serious side effects. If you are taking pain relievers on most days, tell your doctor. You may need to be watched for side effects. Your doctor may want to check certain blood tests.
Capsaicin (Zostrix) is a skin cream that may help relieve pain. You may feel a warm, stinging sensation when you first apply the cream. This sensation goes away after a few days of use. Pain relief usually begins within 1 - 2 weeks.
You can also buy over-the-counter or prescription NSAIDs that come in the form of a skin cream.
Steroid Shots for Arthritis
Corticosteroids injected (steroid shot) right into the joint can also be used to help with swelling and pain.
However, relief lasts only for a short time. More than two or three injections a year may be a harmful. These injections can be performed at your health care provider's office or with the guidance of ultrasound or x-rays.
When the pain seems to go away after these injections, it may be tempting to go back to activities that may have caused your pain. When you receive these injections, ask your doctor or physical therapist to give you exercises and stretches that will decrease the chance of your pain returning
Other Injections for Knee Arthritis
Hyaluronic acid is a substance already in the fluid of your knee. It helps protect the joint. When you have arthritis, the hyaluronic acid becomes thinner.
Your doctor can inject a form of hyaluronic acid into your joint to help protect it. This is sometimes called artificial joint fluid, or viscosupplementation.
These injections cannot help everyone, but if they do help, the relief may last 3 - 6 months. Hyaluronic acid is used mostly for knee arthritis.
The body naturally makes both glucosamine and chondroitin sulfate. They are important for healthy cartilage in your joints. They both can also be bought over the counter as supplements.
- Glucosamine comes as glucosamine sulfate, glucosamine hydrochloride, and n-acetyl glucosamine. These products may come in tablet, capsule, and powder forms.
- Chondroitin sulfate comes in capsules or tablets. It is often combined with glucosamine.
These supplements may help control pain. However, they do not seem to help your joint grow new cartilage or keep your arthritis from getting worse. Some doctors recommend a trial period of 3 months to see whether glucosamine and chondroitin help.
S-adenosylmethionine (SAMe, pronounced "Sammy") is a man-made form of a natural byproduct of the amino acid methionine. It has been marketed as a remedy for arthritis, but scientific evidence to support these claims is lacking.
Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011 Jun 18;377(9783):2115-26.
Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, Abram F, Dorais M, Pelletier JP. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 Jun;70(6):982-9.
Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, Reichenbach S, Trelle S. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ. 2010 Sep 16;341:c4675. doi: 10.1136/bmj.c4675.
Review Date: 8/12/2011
Reviewed By: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, and Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.


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PM raises hopes for LNG deal
Page Tools
Australia's biggest single resources development, the North-West Shelf project, is well-placed to secure part of a multibillion-dollar contract to supply South Korea with liquified natural gas, according to the Prime Minister, John Howard.
Mr Howard's cautious optimism about a mammoth long-term deal with Korea Gas Corp, worth about $US30 billion ($38.6 billion) in total, came after he held talks with South Korea's new President, Roh Moo-hyun.
"There are final decisions to be made but I think the flavour was that Australia had good prospects," he said yesterday, adding that any deal would be "mega".
Mr Howard has also pressed Chile's leader Ricardo Lagos to consider Australia as an LNG supplier and will lobby on behalf of Australian companies when he meets Chinese President Hu Jintao today.
The North-West Shelf venture, whose partners include Woodside Petroleum and BHP Billiton, has already snared a 25-year, $25 billion contract to supply China's Guangdong province with LNG and is bidding for similar-sized contracts in other provinces.
Korea Gas, one of the world's largest buyers of LNG, is expected to spend up to $US30 billion over 20 years from 2008, with the deal expected to be divided into three tranches to allow more than one consortium to share in the spoils.
The North-West Shelf consortium is considered to have an excellent chance of getting at least one of the contracts. A decision is expected in the next few months.
Another WA-based consortium, the Gorgon project backed by ChevronTexaco, failed to make the shortlist that is believed to include ventures in Yemen, Iran, Malaysia and Russia.
Underpinning the demand for Australian LNG is the record high price of oil and fears that the rapid industrialisation of the world's two most populous nations - China and India - will see oil prices remain high well into the future.
The high demand has prompted a scramble among the world's oil and gas majors.
Gorgon is due to start production in 2008 while Shell's $US10 billion Sakhalin project in the Russian Pacific, BP's Tangguh venture in Indonesia and ConocoPhillips' $US1.5 billion Darwin plant are all seeking customers.
Woodside last week confirmed it hoped to double oil and gas production by the end of the decade thanks to continued growth of its LNG business in Australia and rising oil production from Africa. But the Perth company once again warned it may pull out of the controversial $7 billion Greater Sunrise project if the stand-off between the East Timorese and Australian governments continues.
Woodside chief executive Don Voelte has put a December deadline on a resolution but admitted the boundary dispute could take years to resolve.
"I think where it's at, we've said the end of the year, is kind of where we have to make our decision as a joint venture operating group," he told the Nine Network's Business Sunday program yesterday.
"If the project does stall we'll move our resources, our people, to other more vibrant projects and come back to Sunrise when the agreements are reached."
Mr Voelte confirmed that Woodside was looking at acquiring BHP's interest in the Corallina and Laminaria oilfields in the Timor Sea.
BHP plans to sell its interest to Britain's Paladin Resources for $195 million. But Woodside has a pre-emptive right to the stake.


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In anticipation of its September 7 360 PC, PS3, and Wii release, Ubisoft has announced a single-player demo of Tom Clancy's H.A.W.X. 2 for the 360 and PS3. The 360 demo will launch on Live on August 16th and on the PS Network on August 17th.
The demo will offer 2 single-player missions:
Interception Course
Take to the air as a Russian pilot sent to intercept a group of stolen aircraft high above the Caucasus Mountains, a hot spot on the world conflict radar, you will be playing a Russian pilot in this mission part of the new multinational cinematic story narrative in H.A.W.X. 2.
Seek and Destroy
Playing from the perspective of the elite U.S. HAWX squadron deployed to settle conflict spilling over in Africa, you are tasked with taking out specific targets with smart ammunition at night. Take off from a carrier under the cover of night and strike against a weapon smuggling operation using precision guided laser bombs.
Official Site: HawxGame.com


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This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The therapeutic effect of transplantation of mesenchymal stem cells (MSCs) in myocardial infarction (MI) appears to be limited by poor cell viability in the injured tissue, which is a consequence of oxidative stress and pro-apoptotic factors. High density lipoprotein (HDL) reverses cholesterol transport and has anti-oxidative and anti-apoptotic properties. We, therefore, investigated whether HDL could protect MSCs from oxidative stress-induced apoptosis. MSCs derived from the bone marrow of rats were pre-incubated with or without HDL, and then were exposed to hydrogen peroxide (H2O2)
An increasing number of studies have described transplantation of mesenchymal stem cells (MSCs) from bone marrow as a strategy for cardiac repair following myocardial infarction [
It is widely reported that high density lipoprotein (HDL) lowers the risks associated with ischemic cardiovascular diseases [
We, therefore, investigated whether HDL could protect MSCs against oxidative stress-induced apoptosis. Additionally, we also examine the effect of HDL on the MSCs senescence, which was regarded to be induced by oxidative stress and to influence cell therapeutic potential considerably. Previously, the effects of HDL on endothelial progenitor cells [
To investigate the effect of HDL on the biological activity of MSCs, we performed flow cytometry and MTS to detect cell differentiation and cell viability respectively. We observed that the MSCs (Passage 4), used in our experiments, expressed typical MSC-related cell surface antigens, which were positive for CD29, CD90 and negative for CD45, CD34; and that the incubation with HDL (100 μg/mL) for 24 h did not exhibit a notably impact on the characteristic phenotypes of MSCs (
To determine the concentration of H2O2, which was employed to induce the cell apoptosis, MSCs was cultured with different concentration of H2O2 for 24 h and a MTS assay was performed afterwards. It was found that H2O2 impaired the viability of MSCs in a concentration-dependent manner over the tested concentration range (
In order to investigate the effects of HDL on H2O2-stimulated MSC apoptosis, MSCs were pretreated with or without HDL (100 μg/mL) for 24 h and then cultured with 400 μM of H2O2 for an additional 24 h. TUNEL assay showed that incubation with 100 μg/mL HDL did not affect the apoptosis of MSCs (HDL group
Meanwhile, MSCs aging or senescence, which directly impaired the regenerative capability, was widely reported to be induced by oxidative stress [
As previously reported [
The influence of the PI3K/Akt pathway in ROS production based on LY294002 inhibition and assessed using fluorescent probe-DHE demonstrated that the percentage of ROS negative cells with low fluorescence intensity were similarly observed among the Control, the HDL and the LY294002 groups (all
The above results showed that the inhibition of PI3K/Akt pathway attenuated the protective effect of HDL and the decreased ROS, indicating that Akt activation was partly upstream of ROS generation. Excessive production of ROS has been shown to damage stem cells through caspase-mediated pathways [
The poor viability of the donor cell, typically <1% at 4 days after transplantation, has been reported in the previous study regarding MSCs-base therapy [
The effect of MSCs preconditioned with HDL on cardiac function was observed by transthoracic echocardiography four weeks after experimentally induced MI in rats (
We noticed that Kiya Y
In the recent literature, the effect of transplantation of MSCs on myocardial repair was reported as confined for the low viability of graft cells [
Therefore, we explored whether improving the in-situ physiological environment of MSCs could enhance cells viability and prevent oxidative stress-induced apoptosis after transplantation or mobilization. Epidemiological studies have consistently shown an inverse correlation between HDL levels and outcomes in ischemic heart diseases [
Beside apoptosis, cellular senescence had been proved to be the other main outcome following oxidative stress stimuli [
The clinical significance of our results is the possible benefit of HDL in patients with myocardial infarction in terms of improving the survival of transplanted MSCs. Elevation of HDL levels in patients, at high risk of cardiovascular disease may also be of vital clinical importance in preventing cardiovascular events. However, we did not identify the specific components of HDL that were responsible for its anti-oxidant and anti-apoptotic effects in the present study, for HDL is a lipoprotein, containing HDL2 and HDL3, with a density ranged from 1.063 to 1.210 g/mL [
All animal procedures were undertaken in accordance with the Guidelines for the Care and Use of Laboratory Animals, published by the National Academy Press (NIH Publication No. 85–23, Revised 1996). The experiments were approved by the Animal Care and Use Committee of Zhongshan Hospital, Fudan University.
MSCs were isolated from four-week-old Sprague-Dawley (SD) rats weighing 100 to 120 g by flushing femurs and tibias with Dulbecco's modified Eagle's medium (DMEM; GIBCO), 10% Fetal Bovine Serum (FBS; GIBCO) and penicillin/streptomycin. The bone marrow (BM) solution was cultured at 37 °C in an atmosphere of 5% CO2. The culture medium was changed every 3–4 days. Non-adherent hematopoietic cells were removed during this process, and the adherent, spindle-shaped MSCs were cultured and expanded. Passage 4 cells were used for subsequent experiments.
An adenoviral vector carrying a green fluorescent protein (GFP) (GeneChem) for cell transduction was used to establish and identify a stable population of MSCs. Transduction was facilitated by transfecting Passage 4 MSCs with purified adenovirus cells that had been exposed to 7 μg/mL polybrene. The transfected cells were incubated for 24 h at 37 °C with 5% CO2. The medium was removed, replaced with fresh medium and incubated for a further 24 h. Cells were then sorted by flow cytometry for GFP to ensure that a homogenous population of GFP+ MSCs was obtained (data were not shown).
MSCs were incubated for 6 h with DMEM supplemented with 1% FBS prior to experimental interventions. The starved MSCs were then respectively exposed to H2O2 (0 to 500 μM) or HDL (0 to 200 μg/mL; Merck) for 24 h. The experiments were undertaken in four groups: a control group; a HDL group (MSCs incubated with HDL 100 μg/mL for 24 h); a H2O2 group (incubation with 400 μM H2O2 for 24 h); a HDL + H2O2 group (pre-incubation with HDL 100 μg/mL for 24 h, followed by 24-h exposure to 400 μM H2O2). For inhibitor experiments, three additional groups were set as follows: MSCs were pre-incubated with PI3K inhibitor (LY294002, 25 μM) or vehicle (DMSO) for 1 h, and then successively treated with HDL and H2O2 as above; the third group was pre-cultured with LY294002 alone. The concentrations of HDL, H2O2 and LY294002 used in these experiments were determined from pilot studies and based on similar methods described in the literature [
MSC viability was assessed using a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2
Cell apoptosis was investigated using an In Situ Cell Death Detection kit (Roche). In brief, MSCs were fixed in 3.7% buffered formaldehyde, pretreated with 3.0% H2O2 and exposed to TdT enzyme at 37 °C for 1 h. The cells were then incubated with digoxigenin-conjugated nucleotide substrate at 37 °C for 30 min. Nuclei exhibiting DNA fragmentation were identified after staining with 3,3-diamino benzidine (DAB) for 5 min.
The MSCs were counterstained with hematoxylin and viewed by light microscopy. Five fields at high magnification (×200) were randomly chosen to assess the apoptosis index, which was calculated as a percentage of labeled cells to total nuclei.
Caspase-3 activity was determined in MSC lysates (200 μg) using Caspase-3/CPP32 Fluorometric Assay kit (BioVision). The fluorogenic CPP32/caspase-3 substrate was labeled with the fluorochrome 7-amino-4-methyl coumarin. In this assay, the amount of fluorescence produced upon cleavage was proportional to the amount of caspase-3 activity present in the sample.
MSCs cultured in six-well plates were rinsed with phosphate-buffered saline (PBS), fixed and then incubated with freshly prepared senescence-associated β-Galactosidase (SA-β-Gal) staining solution (Beyotime, China) at 37 °C overnight. Five fields at high magnification (×200) were randomly chosen to count the number of blue cells (SA-β-Gal positive cells). At least 500 cells in each group were examined and the percentages of blue cells presented.
MSCs from each group were rinsed with cold PBS and lysed using RIPA buffer containing 1 mM phenylmethanesulfonylfluoride on ice for 30 min. The lysates were transferred to 1.5 mL Eppendorf tubes and centrifuged at 4 °C and 15,000 rpm for 30 min. The protein component was separated by 12% SDS-PAGE and then transferred to polyvinylidene fluoride membranes (Millipore). The membranes were blocked in 5% skimmed milk for 2 h at room temperature, and were incubated overnight at 4 °C with anti-phospho-Akt (Cell Signaling), anti-Akt (Cell Signaling), anti-p16INK4a. Following a 30 min wash, the membranes were incubated for 1 h with a secondary antibody conjugated to horseradish peroxidase-conjugated IgG (Jackson). Protein expression was determined using an enhanced chemiluminescence system and quantified by densitometry (Image System; Bio-Rad).
The production of intracellular ROS was measured using an oxidation-sensitive fluorescent dihydroethidium (DHE) probe (Vigorous). The assay was based on the principle that DHE crosses cell membranes and is rapidly oxidized in the presence of ROS resulting in the formation of a highly fluorescent form of oxidative ethidium.
In this assay MSCs were washed three-times with PBS and incubated with 10 μM DHE in phenol-red-free MEM medium (Invitrogen) at 37 °C in the dark. After 15 min incubation, the cells were rinsed and the medium was replaced. The fluorescence level, as an indicator of ROS production, was detected using fluorescence microscopy. The excitation and emission filters were 488 nm and 590 nm, respectively.
The MI model was developed in SD rats (220 ± 30 g), as previously described [
To observe the donor MSCs survival
Three photomicrographs were taken from the infarct border zone of each section. Six sections were selected for counting, giving a total of 18 high power fields per rat. The numbers of GFP+ MSCs were counted and averaged.
Real-time polymerase chain reaction (PCR) was performed for quantification of the male
Cardiac remodeling and left ventricular function were assessed by transthoracic echocardiography 4 weeks after MI, using a Vevo 770 high-resolution imaging system (Visual Sonics) with a 17.5-MHz probe. After the induction of light general anesthesia, hearts were imaged in two dimensional and M-modes. The recordings were obtained in the para-sternal long-axis view at the level of the greatest LV diameter. The LV internal end-diastolic diameter (LVIDd) and LV internal end-systolic diameter (LVIDs) were measured from M-mode recordings according to the leading-edge method. All echocardiographic measurements were averaged from at least five separate cardiac cycles.
Statistical analysis was undertaken using SPSS version 16.0. All data were expressed as means and standard errors (SE). Between-group of differences was analyzed using Student's
In summary, we demonstrated that HDL protected MSCs from H2O2-induced apoptosis by activation of the PI3K/Akt pathway and down-regulation of ROS generation; and that preconditioning with HDL promoted MSCs survival after cell transplantation, thereby preserving cardiac function. This observation provides an experimental basis for improving the prognosis of patients with myocardial infarction through elevation of HDL levels. The HDL-based therapy may hold the promise of reducing the incidences of such left ventricular remodeling and heart failure after myocardial damage.
This work was supported by grants from the National Natural Science Foundation of China (Project No. 81100145, No. 81000043 and No. 81100075), Shuguang Project of Shanghai (Project No. 08SG03), Research Fund for the Doctoral Program of Higher Education of China (Project No. 20100071120072) and the National Basic Research Program of China (973 Program, 2012CB518605).
The authors declare no conflict of interest.
Effects of H2O2 and/or high density lipoprotein (HDL) on mesenchymal stem cell (MSC) viability and apoptosis. (
Influence of HDL in the MSC senescence. MSCs were treated with or without HDL for 24 h followed by exposure to H2O2 insult for another 24 h or not; (
Role of PI3K/Akt pathway in the HDL induced anti-apoptotic protection. (
Impact of activation of PI3K/Akt pathway induced by HDL on reactive oxygen species (ROS) generation. The intracellular ROS in MSCs was visualized by fluorescent microscopy. Representative photomicrographs (scale bar = 100 μm) and corresponding histograms are displayed. Preconditioning with HDL inhibited H2O2-stimulated ROS generation in MSCs. However, the protective effect disappeared with LY294002 pretreatment. Results were confirmed in three independent experiments.
Effects of HDL preconditioning on transplanted MSCs survival and cardiac function in the rats with experimental MI. (


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Dashclock Uptime Extension is an extension for the Dashclock Widget that displays information about your device's uptime since it was last rebooted.
This extension is free to use when used alone but when used simultaneously with other extensions made by this developer, a small one-time purchase is required to unlock them all.
This application is entirely open-source. If you'd like to have new features or additional languages/locales please raise an issue ticket at https://github.com/mridang/dashclock-uptime or create a patch and send me a pull-request (if you're adventurous enough).
This extension requires the requires the Dashclock Widget by Roman Nurik: https://play.google.com/store/apps/details?id=net.nurik.roman.dashclock
|باز کردن سوکت های شبکه


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Peepers - Wooden Animal Eyeglass Holders
I think they're funny.
I think these glasses will look much snazzier than my usual get up of a piece of white bread hanging out of my mouth as I chop.Added 8 Years Ago from Utilitieshome
so pretty sure the boyfriend would DEF get a kick outta this one. Just sayin...not too mention, I'm actually quite fascinated by how it looks. hehe.
Icy Bling for your drink. I think it would be fun to make the ice cubes with different colors of fruit juice to add a little color and flavor to a drink.
I'm not entirely sure what it is, but I know I like it!Added 10 Years Ago from Drinkstuff.com


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An 82-year-old man arrested over the deaths of two women and four dogs found shot dead at a Surrey farm has been named locally as dog breeder John Lowe.
Police were called to Keepers Cottage Stud, off Crooksbury Road in Farnham at 10am yesterday morning, where detectives discovered the bodies of a woman in her 40s and a woman in her 60s - believed to be mother and daughter - as well as three German Shepherds and one Labrador.
All had gunshot wounds, and a long-barrelled weapon was recovered from the scene.
An 82-year-old man, understood to be dog breeder Mr Lowe, has been arrested on suspicion of murder and is currently in police custody.
Officers working on the case say the victims were known to their suspected killer, and they are not looking for anyone else in connected with the inquiry.
DCI Mark Preston said this afternoon that the incident had been referred to the Independent Police Complaints Commission because of previous police contact with the suspect, but there was no active investigation ongoing.
He added that the two women are thought to be related, but couldn't confirm they were mother and daughter, although he did say they were not residents of the property.
The body of the woman in her 60s was found inside the property, while the woman in her 40s was
Officers attempted to resuscitate the women but to no avail.
DCI Preston said that he could not say who it was that alerted the emergency services, but it is not thought anyone else was at the property at the time.
"There might not be any witnesses to the events that happened yesterday, but there will be people who knew the parties involved and we want them to get in touch.
"At this stage we have recovered one weapon. Forensics will take probably until the end of the week searching the house."
Detective Chief Inspector Mark Preston from Surrey Police said : "It is extremely sad that two people have lost their lives and police family liaison officers are working to support their relatives and friends at this very difficult time.
"We are conducting a full and thorough investigation into the circumstances surrounding these two deaths, however, at this time, we believe this is an isolated incident and there is no further risk to the wider community.
"Officers remain at the scene conducting inquiries and will be on site for some time. This investigation is in its early stages and we will issue updates when we have them."
A spokeswoman for the RSPCA said today that the charity was aware of what had happened over the weekend at Keepers Cottage Stud, and is working with police to look after a number of live animals at the property.
She said this included dogs, horses and a cat, although it was not clear how many were being kept at the farm.


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Mary Tyler Moore will receive the 2011 Screen Actors Guild Life Achievement Award. The award will be presented Jan. 29 at the 18th annual SAG Awards in Los Angeles. "Mary Tyler Moore won our hearts as Laura Petrie and Mary Richards, our respect as her production company became synonymous with quality television, our awe as she tackled difficult subject matter in film and on Broadway, and our admiration she turned her public recognition into a catalyst to draw attention to critical and deeply personal health and social issues," said SAG president Ken Howard. "She truly embodies the spirit behind SAG's Life Achievement Award, and we are honored to proclaim her as its 48th recipient." Moore won two Emmys for The Dick Van Dyke Show and four for The Mary Tyler Moore Show.
Mary Tyler Moore To Receive SAG's Life Achievement Award
11 Comments
I adore Mary Tyler Moore and wish The Dick Van Dyke Show and the Mary Tyler Moore show would be shown on some cable channel. They are still funny 30 years later.
Hulu has most of the episodes for free right now. I own all of the DVDs of both shows – worth the investment. Cable stations just BUTCHER the episodes for commercials. I stopped watching TV Land's airing of classics ten years ago, when I caught "The Dinner Party" '73 episode of "MTM", and they cut most of the Veal Prince Orloff scene. Idiotic. The "editors" obviously knew nothing of the series. They also cut Cloris Leachman's (Phyllis) priceless reaction (Emmy winning) to Betty White's Sue Ann Nivens attempting to steal her husband, in "The Lars Affair" – the "pie scene" is priceless…..but gone on TV Land.
Well-deserved but my real satisfaction comes from knowing that for her to agree to be present for this honor means she has recovered from her recent brain surgery. That's a huge relief.
If Mary Tyler Moore is off screen because she wants to be off screen, cool, but, if she's not showing up much because people aren't casting her, or something like that: seriously, what's wrong with people?
The highest-grossing film out there right now is a serious, grownup drama. There really should be room in mainstream theaters for Woody Allen movies and Mary Tyler Moore movies.
Hob knobbing with Mary Tyler Moore will not wash clean the current SAG regime. They reek of corruption and the sooner Ken Howard and Co are gone, the better off actors will be.
The Dick Van Dyke Show and The Mary Tyler Moore Show were seminal TV events in my life. Not only did they make me laugh ENDLESSLY, but they taught me what was funny, timing and "comedy", but were after school and Saturday night "friends" I could count on to always be there and not desert me just because I happened to be "different". Thank you, Mary for a lifetime of laughs and memories! Congratulations on your much deserved honor from our Guild!
i am surprised that it is not being given to Oprah.
Just watched her work highlighted on a show honoring female comedians. She's had an amazing career. Well deserved.
If anybody deserves honor, Mary Tyler Moore does. She is a national treasure.
I just wonder when the Kennedy Center honchos will finally honor Doris Day. After all, she owned the movie box office for a decade, sang with the best big bands of the day and had a top-ten TV show. And she's a humanitarian. A triple or quadruple threat for sure.
In order to receive an honor from the Kennedy Center you have to agree to show up. I believe Doris Day has turned the invitation down.
Many a baby boomers first crush


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As Ohio State quarterback Terrelle Pryor entered his junior season in Columbus, there were doubts whether his play and attitude would evolve with experience and age.
The answer -- for now -- is yes.
Pryor acknowledged that he began his college career feeling a little cocky and that may have cost him in performance on the field and respect in the locker room.
"I think I was a little arrogant, to tell the truth," Pryor said Sunday, speaking to reporters at Ohio State's team photo day. "You think about it and I came in as a junior in high school and everybody was praising me. ... It can be kind of ... you lose your humbleness. And (now) I feel humble. I feel very humble, very appreciative."
The Buckeyes quarterback seems focused on the little things to improve himself on and off the field with teammates, aiming at the big picture: Returning for his senior season in 2011.
"I want to leave a legacy, that's my goal," Pryor said. "That's why I'll be here for four years. I can't wait. I'm so happy."
So far, so good as head coach Jim Tressel is concerned.
"I think he's played like a veteran these first couple days," Tressel said. "He's got such a foundation now that I've been very impressed with his summer and his first two practices."
--Armen Terjimanian
First-place votes in parentheses.
Football coaches' poll
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"I have a bit of a reputation as a Grim Reaper," she says, with her typically diffident smile.
And once we work that out, as we age, we might even be able to work a stalemate with the Grim Reaper himself.
But the grips of the Grim Reaper have already started to reel him back in.
Nate Silver meets the Grim Reaper, without all the confusing actuarial tables.
In modern times, only a few great writers have been reprieved by the Grim Reaper.
The Grim Reaper was savagely striving to cut life short for one Yank air ace!
Had the Grim Reaper no other harvest whitening for his sickle?
It seemed inconceivable that the Grim Reaper could have worked this grisly change in so short a time!
The Grim Reaper did not spare them, but they were as "treasures laid up in heaven."
They themselves sharpen the scythe of the Grim Reaper who brings the only remedy.
A figure commonly used to represent death. The Grim Reaper is a skeleton or solemn-looking man carrying a scythe, who cuts off people's lives as though he were harvesting grain.


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Dubrovnik Apartment Gordana
Facilities Map Streetview Reviews
Postranjska 6 Postranjska 6
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. Travellerspoint is not responsible for any inaccuracies in the photos.
We offer to our dear guests new and fully equipped Unit 1 - apartment which accommodates up to 2+1 persons, Unit 2 studio apartment for 2 persons (separate beds) and Unit 3 - three double rooms (2+2+2persons) with two bathrooms
Unit 1 - 40 m2 bed private ensuite
3 Stars apartment - kitchen, bathroom, living room, sleeping room ( with two separate beds) television, balcony and parking place.
Unit 2 -28 m2 bed private ensuite
This apartment includes sleeping room with 2 separate beds and kitchen, with television ,air condition, bathroom, parking place. In the front of the apartment there is 40 m2 terrace .
Unit 3 - Apartment has three double rooms and two bathrooms.One of these three rooms can be with separate beds. Also there are air condition, parking places and terrace.
All Units are completely furnished and tastefully decorated. Around the apartments there is a garden with lemon threes and lot of flowers.
Near the house, 5 minutes on foot, there is a post office, shops, cafe bars, disco, market and a tourist agency where you can get all information you need. We provide you free city maps and brochures and all necessary information about the city
You can come to Hostel with a bus number 8 or You can take a taxi. Taxi is not so expensive like in other European countries. For a ticket for bus You will pay 10 kunas no matter how far You will travel inside town. You can buy a ticket in the bus. The bus station, where You get off for Postranjska street, is about 2-3 minutes on foot to arrive to apartments. Taxi is about 50 kunas from the main port Gruz and from the main bus station to these Apartments.
It's also possible to come twalking along The Andrija Hebrang street. The street Postranjska is the third on the left side when You pass bakery shop Rusica.
It takes about 20 minutes pleasant walk from the main station to us and from the port Gruz, too. You can also walk to Old City. It takes about 15 minutes. A pleasant 10 minutes walk will bring you to a nice pebble beach called Bellevue.
It is safe and very quiet place to spend your holiday. From terrace You have a beautiful view on Elafit Islands and port Gruz.
When you arrive at the bus station you can call us to pick you up
This is a Trusted Review. Why?
Mid-aged couple renting the studio for 2 persons and 4 nights. Very happy with our stay. Her hostess Doris was quite friendly and helpful.
This is a Trusted Review. Why?
we booked out both the two and three bedroom apartments which were both fantastic. The host were great anything we wanted they got and they were incredibly friendly. The three bed apartment is MASSIVE which is fab as we'd spent our past travels in small apartments due to needing it to be cheap. The location wasnt great the walks to old town and CC are 15mins roughly, but the hills and steps are steep making walking anywhere abit of a trek. But this did make for a quieter stay. This it was all made up for the fact we managed to pay in kuna instead and the rate they actually charged us in comparison to the price they wanted to charge for euros was incredibly cheap (around £14 pounds a night instead of £19). If you dont mind spending an extra ten minutes walking and want to save some money, this is perfect
This is a Trusted Review. Why?
Really nice place. We stayed here only for 2 days but that were the best two day in our 2-weeks trip. Very good location in the middle of the road from Bus Station to Old Town. Quiet place with good view from terrace to the sea and port. And also Gordana is very nice and helpful. Her advises helped us see the most beautiful place in Croatia – Lokrum island.We can reccomend Apartment Gordana to everybody!
This is a Trusted Review. Why?
This is a Trusted Review. Why?
Very good location-appr. in the middle of the road between Port Gruz and Old Town. For the first time it's easier to take a taxi (from main bus station) than to walk with heavy luggage. There is peace and quiet, beatiful sea view from tarrace- overall, wonderful place to take a rest. There is rather long distance to the nearest city beach - about 30 min walking. Gordana and her sister are very helpful and friendly. Definitely recommended!
This is a Trusted Review. Why?
Staying at Apartment Gordana is like staying at a friends' place. We were welcomed by Gordana and her sister Doris with juice and home-made cake and Doris went out of her way to make us feel comfortable. She dropped us off in her car twice when we had to get the bus/ferry and we did not hesitate to stay an extra night, when we returned to Dubrovnik. The place is indeed a little hard to find initially (take Bus No. 8 from the harbour and walk up steep steps), but once you're there it's very conveniently located between the harbour and the old town. We would certainly stay again and therefore can only recommend Apartment Gordana to other travellers!
This is a Trusted Review. Why?
Excellent stay. Gordana was great company and we spent several evenings drinking wine and watching the sun go down from the terrace.
This is a Trusted Review. Why?
We've been satisfied that Gordana and her family are very kind and helpful. The apartment is situated in the hills, but still it is very good position because we've been close to the old town, to the beaches, to the port, to the main bus station and the big supermarket is only 5 minutes from apartment.
This is a Trusted Review. Why?
Gordana was nice and clean and the room was nice,but we booked a room with ensuite and had to share the bathroom with one other room. This was an irritation at first but Franica made up for the minor inconvenience with her friendly hospitality. It is easy to walk to the city centre or catch a bus. The room had a lovely terrace and nice view over the sea.
This is a Trusted Review. Why?
We chose this place upon reading the positive comments from fellow travellers, and true enough, it was a fantastic place! Gordana was an excellent host, and did not hesitate to come to the bus station to pick us up when we arrived. It would have been a little difficult to find the place on our own otherwise. We had a huge room with an adjoining living room plus kitchen facilities. Gordana even served us with an ice cream each. How's that for a super welcome!The view from the terrace overlooking the Elafiti Islands was simply magnificent. Bravo!
Have you stayed here? Write a review
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. Travellerspoint is not responsible for any inaccuracies in the photos.
Create your own travel plan and bookmark this hotel on your plan. You can even bookmark hotels found on other websites!
Do you have questions about Dubrovnik? You might try asking in our active travel forums and see if anyone else has been there.
Read up on what to see and do in Dubrovnik in the Travellerspoint guide, written by travellers for travellers.


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Marion Police investigate toddler death
MARION, Ind.
Police are investigating the death of toddler Wednesday night.
Marion Deputy Police Chief Cliff Sessoms said a 911 call from a cell phone at approximately 10:00 p.m. led officers to begin their investigation.
Police are not releasing the location, age and gender of the toddler at this point.
Sessoms told Eyewitness News that detectives would only confirm that they are conducting "a death investigation," and that more information may be available later this morning.
Check back for updates to this developing story.


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Police recover one body off Sydney
Page Tools
NSW Water Police found a man's decomposed body in the sea off southern Sydney today.
A NSW police spokeswoman said officers found the decomposed body about 11.50am (AEST) off Cape Bailey, at Kurnell.
People in a passing yacht told police they spotted two bodies in the water, but only one body was found, she said.
Police were searching missing persons lists and making inquiries into the man's identity, she said.
"The body of the man has been taken to Botany Bay Water Police
station where inquiries are being made," the spokeswoman said.
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