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Published: 2002-11-04 16:32:22
Updated: 2002-11-04 16:32:22
-----BEGIN PGP SIGNED MESSAGE----- Hash: SHA1 SECURITY BULLETIN REVISION: 0 TITLE: SSRT2265 HP TruCluster Server Interconnect Potential Security Vulnerability NOTICE: There are no restrictions for distribution of this Bulletin provided that it remains complete and intact. RELEASE DATE: 04 November 2002 SEVERITY: High SOURCE: Compaq Computer Corporation, a wholly-owned subsidiary of Hewlett-Packard Company and Hewlett-Packard Company HP Services Software Security Response Team REFERENCE: SSRT2265, CVE CAN-2002-0711 PROBLEM SUMMARY This bulletin will be posted to the support website within 24 hours of release to http://thenew.hp.com/country/us/eng/support.html Use the SEARCH IN feature box, enter SSRT2265 in the search window. SSRT2265 Cluster Interconnect (Severity High) A potential security vulnerability has been discovered in HP TruCluster Server software that may result in a denial of service (DoS). This potential vulnerability may be in the form of local and remote security domain risks. VERSIONS IMPACTED HP TruCluster Server V5.1A HP TruCluster Server V5.1 HP TruCluster Server V5.0A NOT IMPACTED HP-UX HP-MPE/ix HP NonStop Servers HP OpenVMS RESOLUTION HP TruCluster Server - Early Release Patches (ERPs) are now available for all affected versions of HP TruCluster Server product versions. The ERP kits use dupatch to install and will not install over any Customer-Specific-Patches (CSPs) which have file intersections with the ERPs. Contact your normal support channel and request HP Tru64 services elevate a case to Support Engineering if a CSP must be merged with one of the ERPs. Please review the README file for each patch prior to installation. HP TruCluster Server 5.1A: Prerequisite: V5.1A with Patch Kit 3 (BL3) installed ERP Kit Name: tcv51ab3-c0008601-15346-es-20020905.tar Kit Location: ftp://ftp1.support.compaq.com/public/unix/v5.1a/ HP TruCluster Server V5.1A with PK2 (BL2) installed: update to a minimum of PK3 (BL3) then install ERP tcv51ab3-c0008601-15346-es-20020905.tar HP TruCluster Server 5.1: Prerequisite: V5.1 with Patch Kit 5 (BL19) installed ERP Kit Name: tcv51b19-c0030403-15347-es-20020905.tar Kit Location: ftp://ftp1.support.compaq.com/public/unix/v5.1/ HP TruCluster Server 5.1 with PK4(BL18) installed: update to a minimum of PK5 (BL19) then install ERP tcv51b19-c0030403-15347-es-20020905.tar HP TruCluster Server 5.0A Prerequisite: V5.0A with Patch Kit 3 (BL17) installed ERP Kit Name: tcv50ab17-c0005202-15352-es-20020905.tar Kit Location: ftp://ftp1.support.compaq.com/public/unix/v5.0a/ MD5 and SHA1 checksums are available in the public patch notice and CHECKSUM file for each patch on the FTP site for each of the ERP kits. You can find information on how to verify MD5 and SHA1 checksums at: http://www.support.compaq.com/patches/whats-new.shtml After completing the update, HP strongly recommends that you perform an immediate backup of your system disk so that any subsequent restore operations begin with updated software. Otherwise, you must reapply the update after a future restore operation. Also, if at some future time you upgrade your system to a later patch version, you may need to reapply the appropriate update. SUPPORT: For further information, contact HP Services. SUBSCRIBE: To subscribe to automatically receive future Security Advisories from the Software Security Response Team via electronic mail: http://www.support.compaq.com/patches/mailing-list.shtml REPORT: To report a potential security vulnerability with any HP or Compaq supported product, send email to: firstname.lastname@example.com HP and Compaq appreciate your cooperation and patience. As always, HP and Compaq urge you to periodically review your system management and security procedures. HP and Compaq will continue to review and enhance the security features of its products and work with our customers to maintain and improve the security and integrity of their systems. "HP and Compaq are broadly distributing this Security Bulletin in order to bring to the attention of users of the affected Compaq products the important security information contained in this Bulletin. HP and Compaq recommend that all users determine the applicability of this information to their individual situations and take appropriate action. Neither HP nor Compaq warrant that this information is necessarily accurate or complete for all user situations and, consequently, neither HP nor Compaq will be responsible for any damages resulting from user's use or disregard of the information provided in this Bulletin." (c)Copyright 2002 Hewlett-Packard Company Hewlett-Packard Company shall not be liable for technical or editorial errors or omissions contained herein. The information in this document is subject to change without notice. Hewlett-Packard Company and the names of Hewlett-Packard products referenced herein are trademarks of Hewlett-Packard Company in the United States and other countries. Other product and company names mentioned herein may be trademarks of their respective owners. -----BEGIN PGP SIGNATURE----- Version: PGP 7.0.4 iQA/AwUBPccGTTnTu2ckvbFuEQKQdQCfQoS194u4WvND7txypDzyL8q3KhcAoNsw eWO/gUiIDonH7STuKqYfcphx =ClSE -----END PGP SIGNATURE-----


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An American Approach to World Percussion offers Western-trained percussionists a systematic approach from which to draw on their experience as drumset players and rudimental performers and apply
Imagine a collection of ten easy to intermediate Cajon duets wrapped into one colossal book. Well, imagine no more. Here it is!
As with any instrument, the best way to start is by exploring the different sounds and effects that are possible. Take a Seat helps you do just that with the cajon! After a little improvisation and
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subset: commoncrawl


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Trucking Association of New York: The Voice of Trucking.
For 85 years, the Trucking Association of New York (TANY) (formerly the New York State Motor Truck Association) a non-profit trade group, has represented the trucking industry in New York, advocating for the industry at the local, state and federal levels. We provide educational programs to our membership which enhance their safety and maintenance efforts and offer numerous councils and committees to meet the diverse needs of our membership. The membership is also represented locally by five regional chapters: Metro, Eastern, Central, Genesee and Western.
The TANY comprises over 600 member companies from New York, Canada, every border state, and other states across the country and is the exclusive New York affiliate of the American Trucking Associations (ATA).
TANY In the community
Find out what we're doing to promote safety and education in your community.
join us
Have your voice heard! Become a member of the Trucking Association of New York.


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Go to: Commentary Games Teams Photos TSH Reports Scoreboard Standings Prizewinners
Back to NSSC 2012 Live Coverage
NSSC 2012 Commentary: Round 3
[ ]
Go to: Before the Tournament, Round 1, Round 2, Round 3, Round 4, Round 5, Round 6, Round 7, Final Round 1.
John Williams clarifies that he meant to say "the *first* team to make a 100-point play", and is glad the mistake only cost him $200.
Merriam-Webster is running their usual contest, with the generous prize being a Kindle Touch 3G (and a gift card to purchase the OSPD4 for the device). The students are being asked to identify the following words:
a blue color, adj, 10 points, 8 letters
to gossip, vb, 24 points, 8 letters
standard keyboard, n, 21 points, 6 letters
extremely idealistic, adj, 26 points, 8 letters
to seize a vehicle while in transit, vb, 22 points, 6 letters
a cell formed by the union of two gametes, n, 19 points, 6 letters
to cover with a thin varnish, vb, 12 points, 7 letters
the science that deals with animals, n, 20 points, 7 letters
a question, n, 19 points, 7 letters
a marketplace, n, 17 points, 6 letters
At the end of this round, only one team has a perfect record, 3-0 +250: 11th seed Carlisle Public (MA). Seven more teams are undefeated with less spread: Salem MS 2 (NC), Long Island Linguists (NY), Da Talisman Honchos (NJ), Salem MS 1 (NC), Smith MS 2 (NC), Toronto School Champions (ON) and Bay Farm Montessori (MA).
We are finished playing seriously for the day, and are taking a dinner break before the traditional dessert and game party outdoors at the Wantilan Pavilion starts at 7:30.
At the game party, we had an ice cream bar, and a large number of tables set up with Hasbro games, new and old. There were a few SCRABBLE boards, where kids would sign up to face the likes of Joe Edley, Chris Cree or Stefan Fatsis. For players looking for less intense action, there were Connect 4, Jenga, Twister, Clue, and many other games that were new to me.
As the party wound up at 9:30, a few diehards carried their boards to the lounge, where they were still playing when I left at midnight.
HASBRO is the owner of the registered SCRABBLE® trademark in the United States and Canada. © $year HASBRO. All rights reserved. "SCRABBLE Brand Crossword Game" is the proper way to refer to this unique group of word games and related properties marketed by HASBRO. "SCRABBLE" is not a generic term. To use it as such is not only misleading but also does injustice to the company responsible for the trademark's longtime popularity. All we ask is that when you mean SCRABBLE Brand Crossword Game, you say so.
The SCRABBLE® trademark is owned by J.W. Spear and Sons, PLC, a subsidiary of Mattel, Inc. outside of the United States and Canada.
For more information about SCRABBLE
or the NSA, or to comment on or correct the contents of this page,
please e-mail:
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The Temporary Work (Skilled) visa (subclass 457) is a popular visa category for applicants who are sponsored by an approved Australian company. What most applicants are unaware of is that this visa can also be used by overseas businesses wishing to expand into Australia and employ foreign citizens.
A prospective overseas business must demonstrate that they are lawfully operating outside of Australia and that the business has a legitimate need to establish an Australian operation.
In order to prove that the company has a legitimate need to operate in Australia, the owners must produce a detailed business plan explaining the expansion strategy.
This legitimate need will further be established where the owners can produce evidence of either:
- Contractual agreements for the supply of goods and services to Australian-based businesses, indicating that local businesses would benefit from a local operation being established, or
- An agreement to enter into a joint venture between the overseas business and an Australian-based entity
Once the overseas business has been classified as a sponsor, it may then nominate positions for which foreign citizens may apply. The nomination application must demonstrate that the position requires suitable skills and complies with local labour market conditions, such as salary and working conditions.
There are no age restrictions for this visa and the English language requirements are greatly reduced in comparison to other visa categories. However, applicants must still demonstrate that they have the suitable skills, qualifications and experience the position requires.
The 457 visa is a temporary visa, which allows successful applicants to live and work in Australia for four years. After this time, the holder can apply for an extension.
If the employee has lived and worked in Australia for two years and meets all of the relevant criteria, they may apply for permanent residence.


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Anesthesia Billing Inc
1715 Medical Pkwy
Newton KS 67114
(316) 281-3700
(800) 835-2231
Physician Billing Services || Frequent Questions || Articles || ABI History || Quick Links || Contact Us || Home
We provide a simple solution for data capture that will boost your efficiency by reducing administrative reworking and eliminating the job of scanning, faxing and data entry. Our new pen data transfer technology is cost effective because it removes costly correction routines and reduces the risks for errors. When Anesthesia Billing handles your pain management billing, you can rest assured that your business lifeline is intact.
Tweets by @abi_phil


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Singing sensation Alexa Goddard will perform alongside some of the biggest names in the pop industry this summer.
The 25-year-old from Yateley will open the main stage at Wireless Festival, a month before her debut single Marilyn is released.
Having recently signed to Jay Z's record label, Goddard said she was "ecstatic" to be performing at a music festival of which she is a big fan.
"I went to Wireless last year to watch and I couldn't wait to perform on stage there one day," she said.
"After the event, my management said they would see what they could do. I am opening the main stage, which I didn't expect to be doing. I am so happy and feel so lucky."
The likes of Ellie Goulding, Outkast and Goddard's personal favourite, Bruno Mars, are among the line-up of the festival taking place over the weekend of July 4-6.
Wireless Festival, launched in 2005 and managed by Live Nation, visits both London and Birmingham this year, having started in Hyde Park only.
Goddard, who started singing at the age of 14 and studied at Yateley School, performed at Yateley's first ever music festival, Gig on the Green, in 2011.
In March 2010, she created a YouTube channel with the username AlexaMusicTV. She uploaded various videos of her own covers of R&B hits and released four cover versions as singles, using social media to promote them.
The biggest-selling of these was her version of Turn My Swag On, which reached Number 20 on the UK Singles Chart and the top of the UK Indie Chart.
Goddard developed the YouTube strategy with her manager Stew Mclean, who is also from Yateley, and she soon caught the attention of Jay Z's record label, Roc Nation.
The official music video for Marilyn was shot in LA last month. The track will be released on August 17, but will be available for pre-order on iTunes later this month.
Goddard is looking to release a second single in November and an album early next year.
Over the next few months she is spending a lot of time promoting her music, but still finds time for a bit of cooking and family time.
"Any free time I have I make the most of seeing friends and family," she said.
"There will be times when I am away for long periods of time so when I am at home I like to chill, although I always end up going back to my music.
"I also like taking my dogs for a walk and I love cooking. When I am working I always have to grab sandwiches."


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Ask the Etiquette Experts: Tips for Hosting Your First Thanksgiving
Preparing a giant holiday meal for your big, hungry family is a daunting enough task as it is. And when it's your first time establishing the traditional Thanksgiving feast at your house, it can be even more stressful.
Preparing a giant holiday meal for your big, hungry family is a daunting enough task as it is. And when it's your first time establishing the traditional Thanksgiving feast at your house, it can be even more stressful.
Taking on hosting duties for the first time is no easy feat. Among creating the perfect menu, picking out decorations that are chic without being cheesy and making sure the house is spotless – we are getting exhausted just thinking about it – it's easy to get overwhelmed.
Luckily, we reached out to some etiquette experts who answered some of the toughest hosting questions, and revealed how to make your first hosting gig run as smoothly as possible.
Focus on Family, Not Perfection
While it's hard not to give yourself a panic attack over how much goes into hosting a family dinner, and making sure you have enough time and money to pull it off, Jorie Scholnik, Etiquette Associate at The Protocol School of Palm Beach, reveals that's one of the biggest mistakes you can make.
"Just relax and have fun and know that everyone has showed up to be with you and enjoyed the holiday, and that's what it's all about," she says. "That's a mistake, not enjoying the holiday."
Of course, once we commit to playing hostess for the holidays, it's hard to ask for help – which can make ourselves our own biggest obstacle.
"Don't hesitate to ask friends and family members to bring a favorite dish, or purchase certain dishes from the grocer to fill in," Diane Gottsman, National Etiquette and Modern Manners Expert, says.
To Potluck or Not to Potluck?
If you know you won't be able to make all of the holiday food yourself, let family members know ahead of time that this will be a potluck-style dinner.
"Determine what you will provide, and then develop a means of communication to get guests involved with signing up for the items they'd like to bring," Elaine Swann, Lifestyle and Etiquette Expert, tells us.
Making Room
Even if you come from a big family, there isn't always enough space for everyone. But the biggest mistake Gottsman says people can make during the holidays is not having enough seating for everyone who is coming.
"Plan your seating arrangements in advance and rent or borrow more chairs if necessary," she says. And if a lack of space is an issue in your small house or apartment (we New Yorkers sympathize), she adds it's not out of question to turn away some extended family members and their significant others – just let them know with enough time in advance.
Getting Rude Uncle John to Shut Up
So the dinner is served, wine is flowing and everyone is stuffing their faces full of mashed potatoes and gravy. But your obnoxious Uncle John won't stop with his crude, insensitive comments, and it's making everyone else uncomfortable. So should you confront him? Yes, says Gottsman – just not in front of everyone else.
"Do it privately and assertively," she insists. "Say, 'John, I know you may not realize that your comments are very offensive. I don't want my children, or my guests to hear your off-color remarks or your bad language. Would you please monitor your voice and your comments while visiting at our home? I appreciate your effort to make our family gatherings comfortable for everyone."
Wrapping Up the Meal & Saying Goodbye
Assuming Uncle John has toned down his, um, colorful remarks, and dessert has been devoured, it's OK to drop some not-so-subtle hints that the gathering is coming to an end.
Swann says a simple, "well, it's time that we wrap things up for the evening" and a polite thank you should suffice.
Cleaning up the dinner table and kitchen, or finally standing up at the dinner table while everyone is seated are usually two universal cues that it's time to wrap up the evening, according to Scholnik.
And unless you have a specific need to keep all the leftovers to yourself, you should offer your guests some plates and baggies to go, assuming you have enough to go around. If leftovers aren't offered, but a guest still requests to take some food home, don't make things awkward – kindly wrap up the leftovers and send them along, unless there's a good reason not to.
With your fridge piled high with leftovers in other people's serving trays and plates, be sure to wash them when you're done and give them back to the appropriate owner the next time you see him or her. The experts all agreed that if it's a nice serving platter, or something they'll need for their own upcoming festivities, make a point to give it back on the sooner side – after it's washed, of course.
Just remember these key tips, have plenty of booze on hand, and keep in mind that Thanksgiving is about family above all else. Yes, even above pumpkin pie.
Jennifer Kelly Geddes has hosted Christmas cookie swaps, New Year's open houses, Thanksgiving for 22, and all manner of dinner parties in her Manhattan and Ghent, NY homes.Read More »


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The Ultimate Wrinkle Killer
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This Wrinkle Terminator Kit is so powerful you will see amazing results beyond your wildest imagination. The ultimate wrinkle destroyer kit formulated to stop wrinkles, furrows and lines dead in their tracks. These 4 incredible products combined will work miracles on your aging skin, no matter how bad it has become.
There are 4 crucial steps we must take if we want to terminate those aging crevices and lines that seek to embed themselves into your skin. Cleansing our face of course is vitally necessary, but it is a must to exfoliate in order to rid of the old skin so that anti aging ingredients can absorb readily into our skin. We need a gentle, all natural skin rejuvinating exfoliate, one that has been around for over 3000 years called Pearl Powder...Genuine, High Grade, Pure Freshwater Pearl Powder.
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And lastly but not least, as we lay our head at night to sleep, it is essential that we protect our skin with a skin fighting, skin combating, skin warding off cream, so that in our deepest, sweetest dreams, are dreaded enemy "The Wrinkle" CANNOT slip in to attack. You will need La Crème de la Crème, Sarah's Ultra Lush, Luxurious, Deep Wrinkle Pearl Crème.
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World's NO. 1 anti aging Cream . Supreme Deep Wrinkle Peptide Cream 6 provides refreshing moisture to skin cells to reduce roughness, reduce wrinkle depth and restoring natural, youthful elasticity - leading to reduction or elimination of wrinkles and reversing pre-mature skin aging. Supreme Deep Wrinkle Peptide Cream contains Argireline®, Matrixyl 3000, and Matrixyl, a breakthrough ingredient from France.
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Sarah's Pearl Crème is the ultimate wrinkle terminator. You will feel like the Empress herself when you wake up in the morning after indulging in sleep with this rich, lush, fluffy, weightless, vitamin enriched cream absorbed into your skin.
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This prolific wrinkle terminator kit, if purchased seperately would cost a total of $114.80 . Now it can be yours for the low, low price of $79.95 a $34.90 savings - 45 - 60 day supply with no electronic billing.
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It's one thing to talk about sustainability and green building; it's something else to actually do something about it. And that's where Holcim is stepping up. The company's Envirocore Web site, www.envirocore.us, provides a wealth of information on concrete as a sustainable material.
The site was launched last fall, along with the Envirocore product line, and the reference material on it has continued to grow. One of the things I like best is its Green versus Traditional Building comparison. The comparison shows the cost of energy for heating and cooling over a 60-year period. But as you move the slider from left to right, it also shows the difference in periodic maintenance and replacement needs between the two, specifically in roofing, siding, and driveways.
The LEED (Leadership in Energy and Environmental Design) section includes an overview and explanations of the various LEED rating systems. For example, you might be surprised to learn that there are now LEED systems for new construction, existing buildings, commercial interiors, core and shell, homes, and neighborhood development. While some is still under development, the information provided gives insights into what to expect.
For example, the section reports that unlike most LEED systems that focus primarily on green building practices, "LEED for Neighborhood Development will emphasize smart growth aspects and neighborhood design of development." The hyperlinks allow you to download the preliminary draft documents on this and other programs under development.
Another interesting feature is the LEED calculator. This tool first has you choose one of the six programs, then walks you through the categories applicable to that program. Selecting Commercial Interiors yields six categories to explore. Looking at Materials & Resources, with a potential of 14 points, we see that one item, Storage and Collection of Recyclables, is required. One click brings up a commentary that includes an explanation of its intent, the specific requirements, required submittals, and tips on potential technologies and strategies for earning each credit.
If you meet the criteria, you can click that you expect to qualify for that point. Checking the summary shows you how many points you've checked off and where you stand against the rating system.
Concrete credits
A link at the bottom of the form offers suggestions on how concrete as a building material can contribute to earning each of the credits in any given section. Where applicable, it also lists how using specific Envirocore products might be considered as support for individual credits.
For example, look under New Construction, where Materials & Resources offers 13 possible credits. By going to the list of recommendations, we see four areas where suggestions are provided, including two, Recycled Content and Regional Materials, where using any Envirocore product can help earn four credits.
The site also includes several reference sections. The Heat Island section explains the phenomenon, with good graphical illustrations. It provides links to more in-depth information, such as research from the National Center of Excellence on SMART Innovations at Arizona State University.
The Product Specifications tab brings up a PDF file on the Envirocore line of products. These sample products support several of Holcim's eco-efficiency goals.
Finally, the Links section directs you to many recognized authorities in the cement and concrete arena, such as the Portland Cement Association's Concrete Thinker, The Green Building Alliance, and others.


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SaaS, one of the many cloud-based services out there, will see adoption speed up considerably in 2010, even among big companies, Carr says. He expects corporate use of Infrastructure-as-a-Service (another flavor of cloud computing in which the buyer relies on equipment owned by the service provider) and Platform-as-a-Service (IaaS with a software development framework on top of that) also will grow, though at a slower pace since these types of services tend to be used to augment, rather than replace, existing in-house resources.
"What surprised me is how rapidly companies have at least embraced the idea of cloud computing, even if they're not rushing to invest in it," Carr says. "Even a year ago, and certainly two years ago, it wasn't considered a serious option by most companies. Today it really is on the agenda."
Hologic's Rudzinsky is getting ready. His teams have put a lot of time and effort into cost-cutting projects such as centralizing IT infrastructure, rationalizing enterprise applications and consolidating IT vendors. "Those kinds of things are really important to try to keep the shop under control," he says. The next logical step is to tap the cloud.
In 2010 he plans to explore more outsourcing and managed services opportunities with an eye toward "keeping what's core to the business in IT and getting rid of the rest." For instance, it may be time to turn over applications such as ERP and CRM to an outside provider.
"We host those things today, but we're looking to move them out of our data center into someone else's data center. We want this capacity on demand. I want to be able to say, 'Hey, we've got a really busy time coming up, you need to make sure you're allocating more processing power, memory, and disk for me,'" Rudzinsky says. "That will take away some of the big chores that we have today and allow us to focus on things that will provide business value."
That's what the new normal requires: judicious use of sparse resources.
Yes, budgets are tight and staffs are lean. But barring an economic relapse, IT is poised to move forward on projects that portend big changes in IT service delivery. Thrift and innovation don't have to be mutually exclusive.
This story, "Tech Industry Trends 2010: A Year of Guarded Hope" was originally published by Network World.


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Jarrow Formulas, N-Acetyl Tyrosine, 350 mg, 120 Capsules
Quantity Discount
Buy 4+Save 5%
Buy 12+Save 10%
- You earn loyalty credit for every order you place at iHerb!
- Loyalty credit is equal to 5% of the value of your order, excluding shipping charges.
- Your loyalty credit will be applied towards your next order as soon as your current order has shipped.
- Your loyalty credits are valid for up to 60 days from the date of your last purchase.
Jarrow Formulas, N-Acetyl Tyrosine, 350 mg, 120 Capsules
Expiration Date:?Jun 2019Expiration Date
The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:?0.14 kgSwitch to Imperial units
- Product Code: JRW-15051
- UPC Code: 790011150510
- Package Quantity: 120 Capsules
12.7 x 6.9 x 6.9 cm , 0.11 kgSwitch to Imperial units
- £8.80
- £3.89
- Supports Brain Function
- Dietary Supplement
N-Acetyl Tyrosine is an acetylated derivative of the amino acid L-tyrosine. Ordinary L-tyrosine is less stable and also less soluble in water, which may result in reduced bioavailability. Acetylation enhances the solubility and stability of certain amino acids.
N-Acetyl Tyrosine supports brain function by supporting the synthesis of the catecholamines norepinephrine and dopamine (neurotransmitters).
Suggested Use
Usage: Take 1 capsule 1 or 2 times per day, preferably with juice on an empty stomach or as directed by your qualified healthcare professional.
Other Ingredients
Cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of gelatin.
No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.
Note: If you have a medical condition (especially bipolar, high blood pressure, or a history of malignant melanoma), are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially MAO inhibitors), consult your qualified healthcare professional before using this product.
Keep out of the reach of children.
|Supplement Facts
|Serving Size: 1 Capsule
|Servings Per Container: 120
|Amount Per Serving
|Vitamin B6 (as pyridoxine hydrochloride)
|5 mg
|N-Acetyl Tyrosine
|350 mg
|* Daily Value not established.
precursor for dopamine and thyroid hormone
Verified Purchase
precursor for dopamine and thyroid hormone
Dopamine is responsible for the feeling of well-being and prevention of depression. As there are no drugs available to boost this neurotransitor for non-Parkinson's patients, tyrosine is the only substance available to take to boost these levels. (and the n-acetyl form has shown to be most effective). Most commonly depression is related to a serotonin deficiency, but the second most common neurotransmitter assisting depression is dopamine. If 5HTP doesn't help (to raise serotonin levels) then the logic next step is to try tyrosine. It's best taken on an empty stomach. It's good to boost thyroid hormone in patients with hypothyroid as well.
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Great product
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text: As an overly sensitive young boy whose natural propensity for interspecies empathy was amplified by a fondness for Disney movies and a long-standing subscription to Ranger Rick magazine, the idea of hunting appalled me. With a kid's logic, I'd decided that killing animals was unspeakably cruel. Now, please pass the bacon.


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Premiership favourites Sydney are entering the last month of the home and away season with a near full-strength list, but it bodes ill for club legend Ryan O'Keefe, whose hopes for a senior recall fade with every week.
The decorated veteran faces the unpleasant prospect of playing out his career in the NEAFL having not played in the seniors since round four.
And he was not given any cause for optimism by coach John Longmire, who hinted on Monday that the 2012 Norm Smith medallist had an uphill challenge to break back into the Swans side.
"As it sits it's going to be a bit of a challenge if he hasn't gotten in at this point," Longmire said. "You never know what's around the corner."
It would take a significant stroke of bad luck on the injury front for the Swans to pave the way back for O'Keefe, given the number of players who have been afforded opportunities since his axing more than four months ago.
In that period, the Swans have handed debuts to four youngsters – Dean Towers, Zak Jones, Tim Membrey and Jake Lloyd – and they have also turned to up-and-comers Gary Rohan and Brandon Jack when openings have arisen, while Harry Cunningham has played every game this season.
The rise of Luke Parker as a prolific contested-ball winner and Ben McGlynn's development as the Swans' primary defensive-midfielder has all but shut the door on O'Keefe playing any role as an on-baller.
"We've been pleased with the balance of the senior team and how they've been going. It's been a tough team, particularly in the midfield, to break into," Longmire said. "It'll be a challenge for him but Ryan's a pretty resilient character."
O'Keefe's management said last week the the 33-year-old, who is an unrestricted free agent, was keen to explore options elsewhere next season but Longmire said he has since been told by O'Keefe no decision had been made for next year.
O'Keefe's cause has not been helped by the Swans' blessed run with injury this year, which is a marked contrast to their campaign last year.
The Swans have used a competition-low 31 players and have 10 who have not missed a game this year – a number matched only by North Melbourne.
The likely returns of Lance Franklin and Dan Hannebery from injury this week for the clash against Port Adelaide means the Swans will be able to field arguably their strongest 22 of the season. "It wouldn't be far away from it," Longmire said.
He said Hannebery would not be asked to come back via the reserves despite missing the past seven weeks with an ankle injury.
"If he's available for selection he'd be pushing very hard in the senior team because he's a naturally fit player, he's an extremely good endurance runner, he's done a lot of work and he's an important player for us," Longmire said.
He brushed off suggestions gun youngster Tom Mitchell, who has been linked to a move to Carlton despite being a contracted player, was out of favour at the Swans.
Dogged by knee and ankle issues this year, Mitchell has not played in the seniors since round four and managed only 2½ games in eight weeks.
"I think you just need to have a look at the facts, he hasn't been able to play or train consistently," Longmire said. "We know he's a really good player but you've got to be able to train and play to play at any level. I hope he's able to do that in the next few weeks but it's very difficult to get a game in the seniors if you're not playing in our reserves team.
"Apparently he's pulled up well today. We need him to increase his game time now and hopefully get him up to full fitness because the season's fast racing towards the end. He needs to make sure he gets some fitness at training and in games."
The Swans are expected to announce premiership-winning midfielder Craig Bird has agreed to terms on a new deal tying him to the club until the end of 2016.


text:
Citation: Brena RM, Plass C, Costello JF (2006) Mining Methylation for Early Detection of Common Cancers. PLoS Med 3(12): e479. https://doi.org/10.1371/journal.pmed.0030479
Published: December 26, 2006
Copyright: © 2006 Brena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The authors have received funding from the Leukemia and Lymphoma Society of America (CP), the National Institutes of Health (CP, JFC), the National Lung Cancer Partnership (RMB, CP), and the American Cancer Society (JFC).
Competing interests: CP is a consultant for Epigenomics and Quest Diagnostics.
Cancer is one of the most common causes of death worldwide. Lung cancer is the leading cause of cancer-related death worldwide [1], with a five-year survival rate of 10% in Europe and 15% in the United States [2,3]. Strikingly, for lung cancers detected in their early stage, the rate of recurrence within five years is less than 50%. When detected early, current therapies often cure common cancers, including those of the lung, breast, colon, rectum, stomach, and prostate [4]. Therefore, the development of reliable, noninvasive, and cost-effective early detection methods for common cancers is a priority of translational cancer research. Theoretically, a single method that detects multiple common cancer types at an early stage would have the biggest payoff for cancer control.
The Ups and Downs of DNA Methylation in Cancer
Biomarkers of cancer cells have been derived from the genetic mutations and epigenetic alterations, such as DNA methylation, that together transform normal cells into tumors. DNA methylation involves the addition of a methyl group to sites where cytosine is followed by guanine along the DNA (i.e., a CpG dinucleotide, with p indicating the phosphate backbone that connects the cytosine and guanine nucleotides), and is essential for chromosome stability, maintenance of gene expression states, and proper telomere length in normal cells [5]. In primary human tumors, however, DNA methylation patterns are severely disrupted. This disruption includes aberrant gain of DNA methylation at CpG islands (short stretches of DNA with an abundance of CpG dinucleotides, located in gene regulatory regions) and loss of methylation in single copy and repetitive sequences. While CpG island methylation is associated with gene silencing, hypomethylation can result in gene activation and chromosomal instability [6].
There remains a potentially vast, untapped resource for cancer-specific methylation biomarkers.
The subset of CpG islands subjected to aberrant methylation in primary human tumors is non-random, due in part to selection of gene silencing events that favor unregulated cell growth, and also due to intrinsic sequence properties that may underlie gene-specific susceptibility to methylation [7–10]. One hypothesis is that alterations in DNA methylation play a key role in tumor initiation, and if this is true, methylation markers are ideally suited for detecting cancer in the early stages [11,12].
In contrast to tumor type–specific methylation markers, pan-cancer methylation markers could detect a far greater number of early stage cancers. Initial results of a prospective study of such markers are encouraging [13]. Belinsky and colleagues used aberrant methylation in a six-gene panel to detect lung cancer in sputum samples taken months to years prior to the clinical onset of cancer [13]. Other bodily fluids are similarly useful for detection of noninvasive cancer via methylation markers, such as urine for kidney, bladder, or prostate cancer, and serum or nipple aspirates for breast cancer [14,15]. Notably, the panels of aberrantly methylated genes in these different tumor types overlap significantly, indicating that assays for pan-cancer methylation markers are already available for testing. The important role of aberrant methylation in cancer detection and prognostication has been established on a small proportion of the CpG island–containing genes. Thus, there remains a potentially vast, untapped resource for cancer-specific methylation biomarkers.
A New Study of Pan-Cancer Methylation Markers
In a new study published in PLoS Medicine, Shames et al. aim for a big payoff by searching genome-wide for CpG island methylation markers characteristic of not just one type of cancer, but common to several cancers of epithelial origin [16]. Identification of such markers could facilitate detection and diagnosis, and might also shed light on molecular pathways that are characteristic of tumorigenesis in general, potentially providing new clinically relevant therapeutic targets with more widespread application.
Shames and colleagues began the quest for a pan-cancer marker by gene expression profiling of non-small cell lung cancer cell lines before and after treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine. Their initial goal was to find genes expressed in a normal cell from which the tumor might arise, namely human bronchial epithelial cells, but silenced in the cancer cell lines and reactivated by inhibition of DNA methylation. The initial experiment netted 132 tumor-specific candidates. Winnowing this gene subset to a manageable 45 genes involved random selection, and was followed by validation of gene silencing in primary lung tumors relative to the tumor-free adjacent lung.
The eight most frequently methylated genes obtained from the lung cancer data were then tested in a set of 109 tumors from breast, colon, and prostate. Four genes, BCN1, MSX1, CCNA1, and ALDH1A3, showed extensive DNA methylation in all four epithelial cancers. In particular, BNC1 and MSX1 were highly sensitive and specific for tumor detection.
The authors concluded that key pathways altered epigenetically in the tumorigenic process may be shared across cancers of epithelial cell origin, despite obvious differences in their tissue source. This finding is of importance, since it highlights the possibility of identifying a common epigenetic denominator acting across tumor types, and perhaps underlying malignant transformation in general.
However, we must again consider that these genes may be susceptible to aberrant DNA methylation, which could be due in part to their primary DNA sequence. Thus, it remains to be determined if the high frequency of DNA methylation observed in the BCN1, MSX1, CCNA1, and ALDH1A3 genes stems from a functional need to abrogate expression and thus contribute to tumor initiation and/or progression, from an intrinsic susceptibility of these loci to aberrant DNA methylation, or both. In either case, their utility as markers of cancer cells will be unaffected.
Cautions and Clinical Implications
One hazard of using DNA methylation as a marker of cancer is the distinct possibility of false positives. The perfect marker would detect all cancer cases (100% sensitivity) and would not mistake normal cells for cancer cells (100% specificity). However, the influence of ageing, diet, or hormones on DNA methylation may confound results if even a minor fraction of normal cells are methylated at the gene of interest in cancer-free individuals. This cautionary note has been sounded by Shames and colleagues [16] and by others [17]. The problem is that an assay sufficiently sensitive to detect a rare cancer cell in blood or bodily fluids could be particularly susceptible to this pitfall. Nevertheless, developing a single routine test for major cancer types in at-risk or asymptomatic individuals, paired with follow-up tests for specific malignancies, is a goal of high priority.
Efforts toward the perfect universal DNA methylation marker for early detection of tumors are well underway in research laboratories worldwide. Epigenetics researchers from Asia, Europe, and the US are joining forces to map the entire epigenome of normal and cancer cells [18]. Assays are currently available to detect aberrant DNA methylation in samples such as sputum, blood, feces, urine, and nipple aspirates, which can be procured via minimally invasive procedures and are likely to contain tumor cells and tumor DNA shed from a primary tumor mass [14,15].
Research endeavors such as these of Shames et al. are pivotal for the first phase of identification of suitable markers. Technological advances, such as the development of DNA methylation arrays, will undoubtedly aid in the methylation marker discovery phase. The next phase will include testing markers retrospectively and then prospectively in clinical settings, in a high-throughput and cost-effective manner. Coupling the discovery of new DNA methylation markers with investigation into their functional relevance will benefit early detection efforts and improve our understanding of the tumorigenic process.
Currently recommended methods for early detection of cancer include spiral computed tomography for patients at risk for lung cancer, breast exams and mammography for breast cancer detection, fecal occult blood tests and colonoscopy for colon cancer, and endoscopy for gastric cancers. However, several of these methods are expensive, prohibiting large-scale population-based use. It remains to be seen whether the new suite of DNA methylation markers from Shames et al. or those from prior studies will be true pan-cancer markers, and most importantly, whether they will outperform existing methods for early detection.
- 1. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, et al. (2005) Cancer statistics, 2005. CA Cancer J Clin 55: 10–30.A. JemalT. MurrayE. WardA. SamuelsRC Tiwari2005Cancer statistics, 2005.CA Cancer J Clin551030
- 2. Jemal A, Clegg LX, Ward E, Ries LA, Wu X, et al. (2004) Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival. Cancer 101: 3–27.A. JemalLX CleggE. WardLA RiesX. Wu2004Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival.Cancer101327
- 3. Belinsky SA (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 4: 707–717.SA Belinsky2004Gene-promoter hypermethylation as a biomarker in lung cancer.Nat Rev Cancer4707717
- 4. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153–156.DM ParkinF. BrayJ. FerlayP. Pisani2001Estimating the world cancer burden: Globocan 2000.Int J Cancer94153156
- 5. Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415–428.PA JonesSB Baylin2002The fundamental role of epigenetic events in cancer.Nat Rev Genet3415428
- 6. Hoffmann MJ, Schulz WA (2005) Causes and consequences of DNA hypomethylation in human cancer. Biochem Cell Biol 83: 296–321.MJ HoffmannWA Schulz2005Causes and consequences of DNA hypomethylation in human cancer.Biochem Cell Biol83296321
- 7. Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, et al. (2000) Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 24: 132–138.JF CostelloMC FruhwaldDJ SmiragliaLJ RushGP Robertson2000Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.Nat Genet24132138
- 8. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM (2003) Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A 100: 12253–12258.FA FeltusEK LeeJF CostelloC. PlassPM Vertino2003Predicting aberrant CpG island methylation.Proc Natl Acad Sci U S A1001225312258
- 9. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM (2006) DNA motifs associated with aberrant CpG island methylation. Genomics 87: 572–579.FA FeltusEK LeeJF CostelloC. PlassPM Vertino2006DNA motifs associated with aberrant CpG island methylation.Genomics87572579
- 10. Das R, Dimitrova N, Xuan Z, Rollins RA, Haghighi F, et al. (2006) Computational prediction of methylation status in human genomic sequences. Proc Natl Acad Sci U S A 103: 10713–10716.R. DasN. DimitrovaZ. XuanRA RollinsF. Haghighi2006Computational prediction of methylation status in human genomic sequences.Proc Natl Acad Sci U S A1031071310716
- 11. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science 300: 489–492.F. GaudetJG HodgsonA. EdenL. Jackson-GrusbyJ. Dausman2003Induction of tumors in mice by genomic hypomethylation.Science300489492
- 12. Laird PW (2003) The power and the promise of DNA methylation markers. Nat Rev Cancer 3: 253–266.PW Laird2003The power and the promise of DNA methylation markers.Nat Rev Cancer3253266
- 13. Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, et al. (2006) Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 66: 3338–3344.SA BelinskyKC LiechtyFD GentryHJ WolfJ. Rogers2006Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.Cancer Res6633383344
- 14. Cairns P, Esteller M, Herman JG, Schoenberg M, Jeronimo C, et al. (2001) Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin Cancer Res 7: 2727–2730.P. CairnsM. EstellerJG HermanM. SchoenbergC. Jeronimo2001Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.Clin Cancer Res727272730
- 15. Krassenstein R, Sauter E, Dulaimi E, Battagli C, Ehya H, et al. (2004) Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation. Clin Cancer Res 10: 28–32.R. KrassensteinE. SauterE. DulaimiC. BattagliH. Ehya2004Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation.Clin Cancer Res102832
- 16. Shames DS, Girard L, Gao B, Sato M, Lewis CM, et al. (2006) A genome-wide screen for hypermethylated genes in lung cancer identifies tumor-specific methylation markers for multiple malignancies. PLoS Med 3: e486.DS ShamesL. GirardB. GaoM. SatoCM Lewis2006A genome-wide screen for hypermethylated genes in lung cancer identifies tumor-specific methylation markers for multiple malignancies.PLoS Med3e486
- 17. Suzuki K, Suzuki I, Leodolter A, Alonso S, Horiuchi S, et al. (2006) Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 9: 199–207.K. SuzukiI. SuzukiA. LeodolterS. AlonsoS. Horiuchi2006Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage.Cancer Cell9199207
- 18. Qiu J (2006) Epigenetics: Unfinished symphony. Nature 441: 143–145.J. Qiu2006Epigenetics: Unfinished symphony.Nature441143145


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The future of the GOP
In recent days, I read two great pieces that illustrate what I feel is a major problem with my Republican party. The first was an op-ed piece in the New York Times by Maine Republican Senator Olympia Snowe. The second … Continue reading
Posted in National, Politics, Republican Party Tagged Arlen Specter, Congress, GOP, Republican Party, RINO Comments Off on The future of the GOP


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New Artwork by Michael Schultheis
Acerca del libro
Características y detalles
- Categoría Arte y fotografía
Apaisado estándar, 25×20 cm
30 Páginas
- Fecha de publicación abr. 24, 2013
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Davis and Cline Gallery
Ashland, Oregon
The Davis and Cline Gallery is located at the corner of Fourth and A Streets in the Historic Railroad District in Ashland, Oregon. The Gallery was founded by John Davis and opened in March 1998. Originally showing non-objective paintings by West Coast artists, the gallery quickly gained a reputation for the quality of the artists represented and for crisp and uncluttered exhibitions. In the summer of 2000 Chandra Holsten joined the gallery as Gallery Director. Co-founder of the highly respected Holsten Galleries in Stockbridge Massachusetts and Palm Beach Florida, Chandra brought the work of major American and international glass artists to the gallery.
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Get an overview of this hotelHotel in Seward with free breakfast and fitness center
Popular property highlights
Situated in Seward, this hotel is within a 10-minute walk of Alaska SeaLife Center and Seward Museum. Kenai Fjords National Park and Mount Marathon are also within 2 mi (3 km).
Hotel Features
A fitness center, WiFi in public areas, and conference rooms are available at this smoke-free hotel. Continental breakfast is free. Other amenities include self parking, concierge services, and laundry facilities.
Room Amenities
All 76 rooms provide conveniences like refrigerators and microwaves, plus free WiFi and cable TV. DVD players, coffee makers, and hair dryers are among the other amenities available to guests.Information missing or incorrect? Tell us!Opens in a new window
Best Western Plus Edgewater Hotel
Hotel Amenities
Hotel Amenities
Guests can enjoy a complimentary breakfast. Public areas are equipped with wired and wireless Internet access (surcharge). This business-friendly hotel also offers a fitness center, tour/ticket assistance, and concierge services. Onsite parking is available (surcharge).
Best Western Plus Edgewater Hotel is a smoke-free property.
- 24-hour front desk
- Total number of rooms - 76
- Free breakfast
- Concierge services
- Conference space
- Elevator/lift
- Fitness facilities
- Tours/ticket assistance
- WiFi (surcharge)
- Wired Internet access - surcharge
- Laundry facilities
- One meeting room
- Luggage storage
- Safe-deposit box at front desk
- Self parking (surcharge)
- Smoke-free property
Family Friendly Amenities
- Free Wi-Fi
- Laundry facilities
- Refrigerator
- Microwave
- DVD player
Available in all rooms: Free WiFi
Available in some public areas: Wireless internet access ( USD 0.00 ), Wired high-speed internet ( USD 0.00 )
Self parking (surcharge)
Room Amenities
- Pay movies
- DVD player
- Air conditioning
- Microwave
- Refrigerator
- Coffee/tea maker
- Daily housekeeping
- Free toiletries
- Hair dryer
- Shower only
- Iron/ironing board
- Desk
- Cable TV service
- Free WiFi
- Partially open bathroom
- Rollaway/extra beds (surcharge)
Where to Eat
Guests are offered a complimentary continental breakfast.
Nearby Things to Do
Recreational amenities at the hotel include a fitness center.
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- In-room accessibility
- Roll-in shower
Hotel Policies
Check-in time starts at 16:00:00
Check-out time is 11:00:00
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Children and extra beds
- Children are welcome.
- Rollaway/extra beds are available for USD 10.00 per night.
- Cribs (infant beds) are not available.
- Pets not allowed (service animals welcome)
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Only service animals are allowed
No cribs (infant beds) available
Optional extras
- Fee for wireless Internet in public areas: USD 0.00 (rates may vary)
- Fee for wired Internet in public areas: USD 0.00 (rates may vary)
- Rollaway bed fee: USD 10.00 per night
Hotel Name
- Seward Best Western
- Best Western Edgewater
- Best Western Edgewater Hotel
- Best Western Plus Edgewater
- Best Western Plus Edgewater Hotel
- Best Western Plus Edgewater Hotel Seward
- Best Western Plus Edgewater Seward
- Edgewater Best Western
- Hotel Edgewater
- Best Western Seward


text:
The door opened and the girl who called herself Vern Engdahl came in slowly, looking around.
Well be right here, Major, Vern said reassuringly, escorting him to the door.
Then abruptly he scowled again and turned to face Vern and me.
Vern says to apologize for not looking in on you hissbut hes been busy.
Because one of the little things Vern had up his sleeve was that he had found a spot for himself on the Majors payroll.
And in a couple of minutes there was a knock on the door, and she yelled, Come in, and in came Vern.
And it was always Vern, Vern, telling us what to do, ironing out our troubles.
Vern Engdahl wasnt a miss, to begin with; and whatever name he used when he came to call on me, it wouldnt be Vern Engdahl.
With the cowboy Vern setting the pace we plunged after them.
I was getting irritatedat Vern Engdahl, for whatever the hell he thought he was doing; but at her because she was handy.


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Editor of the anthology Working
Together and
Author of The Four-Fold Way
Lao Tzu reminds us that anything propelled by wisdom serves the greater good. The
Power of Collective Wisdom illustrates the responsible and inspirational possibilities available when the commitment and willingness of combined networks, large scale forums, and purposeful collaborative efforts make the health of the larger whole more important than personal agendas. In order to solve problems, share best practices, and to create what we can easily replicate locally and globally, we need to listen to as many voices and options that we have not considered, which is the wisdom found in working and creating together. This book is practical, instructive, and relevant to our times, and invaluable for eliciting the best in any group, organization, community and culture.


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Psychiatric Medications
Brand Name: Klonopin
Klonopin is the brand name for Clonazepam, an anxiolytic and anticonvulsant. Klonopin is a member of the class of drugs known as benzodiazepines, and this drug causes sedation. Klonopin binds to a receptor in the brain (GABA) that helps make neurons less excitable.
Klonopin's effects can sometimes be felt right away, but its full benefits are typically reached in 3 to 4 weeks.
Why is this drug prescribed?
Klonopin is FDA-labeled in adults for treatment of panic disorder and seizures and is FDA-labeled in children up to 10 years age or 30kg for seizures.
Klonopin is also used to treat:
- Seizure disorders (petit mal, atypical, akinetic, myoclonic, or absence)
- Mild to moderate anxiety (short-term therapy only)
- Tourette's Syndrome
- Panic disorder
- Drug-induced mania
- Resistant depression
- Nocturnal myoclonus
- Relieve trigeminal neuralgia (nerve pain)
- Bipolar disorder
How much of this drug is typically used?
Tablet: 0.5 mg, 1 mg, 2 mg
Tablet, orally disintegrating: 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, 2 mg
Warnings and Precautions
Klonopin is very habit forming (addictive) and may become so in only 2-4 weeks of use, causing psychological and physical dependence. It is possible to build up a tolerance for this drug and a dosage increase may be required.
Klonopin should not be discontinued abruptly, or it could cause withdrawal symptoms including abdominal and muscle cramps, behavior disorders, convulsions, depressed feeling, hallucinations, restlessness, sleeping difficulties, and tremors.
Klonopin's effects on children, including possible long-term effects, have not been thoroughly studied. When Klonopin is given to children, dosage should be determined by weight. Side effects of Klonopin and other benzodiazepines are more likely to occur in children than in adults.
For Pregnant or Nursing Mothers: Klonopin may cause birth defects, especially during the first trimester. After that, the fetus may still be affected, and may experience withdrawal symptoms as a newborn. Klonopin passes into breast milk, and may cause sedation and other problems in the infant. Klonopin should not be taken by pregnant or nursing mothers, however in some cases of severe seizure disorder, the risk that seizures pose to both mother and child may be considerable.
Klonopin should not be used for people with the following medical conditions:
- Allergy to other benzodiazepines or related drugs (such as Librium and Valium)
- Liver disease (severe)
- Acute narrow-angle glaucoma
- Acute intermittent porphyria
Klonopin may be used with caution in people with the following conditions:
- Liver disease — lower dosage may be needed
- Kidney disease — drug levels in the body should be carefully monitored
- Difficulty swallowing (in children)
- A history of alcoholism or drug dependence
- A history of stroke
- Multiple sclerosis
- Asthma
- Chronic bronchitis
- Alzheimer's disease
- Emphysema
- Serious depression
- Myasthenia gravis
- Any type of brain disorder
Adverse Reactions
Klonopin's side effects may be different depending on the disorder it is being used to treat. Klonopin may cause the following reactions:
- Drowsiness
- Ataxia (shaky movements and unsteady gait)
- Behavioral disturbances
- Increased salivation
- Insomnia
- Irritability
- Anxiety
- Problems with coordination
- Allergic reaction
- Depression
- Fatigue
- Inflamed sinuses or nasal passages
- Memory problems
- Menstrual problems
- Nervousness
- Reduced thinking ability
- Respiratory infection
- Speech problems
- Tremor
- Abnormal eye movements
- Constipation
- Nausea
- Diarrhea
- Rash
- Thrombocytopenia (fewer platelets in the blood which can cause spontaneous bruising and excessive bleeding of an injury)
- Respiratory depression
- Disordered memory or cognition
- Abnormal coordination
- Change in appetite
- Dry mouth
- Difficulty urinating
- Slurred speech
- Psychological and/or physical dependence
- Low blood pressure
- Agitation
- Confusion
- Dizziness
- Sleep disturbance
- Falls
- Sexual disturbance
- Increased salivation
- Increased liver enzymes
- Joint or muscle aches
- Double vision
- Shortness of breath
Interactions with Drugs and Other Substances
Drugs or substances that may interact with Klonopin include:
- Alcohol, sedatives, other benzodiazepines, or sleeping pills — these medications may cause severe sedation and may be fatal when taken with Klonopin.
- MAO Inhibitors — can lower blood pressure and increase sedation and respiratory depression in combination with Klonopin
- Protease inhibitors such as Cordarone (amiodarone), Norvir (ritonavir) — can lead to drug toxicity
- Tegretol (carbamazepine), tricyclic antidepressants, Dilantin (phenytoin), and Theo-Dur (theophylline) — can decrease the effectiveness of Klonopin
- Tagamet (cimetidine), Antabuse (disulfiram), macrolide antibiotics (such as erythromycin), Prilosec (omeprazole), and oral contraceptives — can increase the effects of Klonopin
Research Studies and Use in Child Psychiatry
A small study with 4 adolescents showed benefit in treatment of frequency of panic attacks and baseline anxiety using Clonazepam 0.5 mg twice daily. (Kutcher & MacKenzie, 1988). In another small study, 0.5 to 3 milligrams clonazepam daily was used successfully in the treatment of severe anxiety disorders with panic-like symptoms in 3 prepubertal children (8 to 11 years of age) (Biederman, 1987). There is a small study of children and adolescents with tic disorder and concomitant ADHD in which adjunctive treatment of clonazepam to clonidine decreased tic frequency and severity without affecting coexisting ADHD symptoms. It is not commonly used for younger children due to the possibility of paradoxical worsening of behavior. Also, like other benzodiazepines, this may have a higher addictive potential, making it not useful for people with substance abuse problems and usually avoided in adolescents if possible.
Off-label use includes restless legs syndrome, sleep walking disorders, and social phobia in adults.
Investigational studies are underway as adjunctive therapy for bipolar disorder and schizophrenia
- http://www.psyweb.com/Drughtm/klonopin.html
- http://www.health—center.com/db/PageReq?SessionID=953&TopicID=338&PageID=1473&Action=view
- http://www.healthsquare.com/newrx/KLO1214.HTM
- http://www.mentalhealth.com/drug/
- http://www.healthtouch.com/bin/EContent_HT/drugShowLfts.asp?fname=use0715.htm&title=Klonopin&cid=HT#GXX05
- www.uptodate.com "Clonazepam: Drug Information"
- www.micromedex.com "DrugPoint® Summary: Clonazepam"
- Steingard RJ, Goldberg M, et al. "Adjunctive clonazepam treatment of tic symptoms in children with comorbid tic disorders and ADHD." J Am Acad Child Adolesc Psychiatry. 1994 Mar-Apr;33(3):394-9.
- Stahl, Stephen M. Essential Psychopharmacology: The Prescriber's Guide. New York: Cambridge University Press, 2006, pp 93-97


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Today's Reader Question concerns how to fix water stains on wood, and whether it's possible to fix oil stains. Dear Katie, I have two questions. My husband put a hot coffee cup on our wooden bedside table and it has left a white mark that I can't get off. Any suggestions? Also oil marks from a coconut oil bottle have stained my vanity table. I desperately want to fix this because it … [Read more...]
How To Fix Scratches On Wood FurnitureThis post may contain affiliate links. Your purchase helps support this site. Thank you!
At a reader's request, I'm sharing my tips on how to fix scratches on wood furniture. As someone who hates the process of sanding and staining or painting furniture, I spent years thinking I'd just have to live with banged-up furniture thanks to my rambunctious kids and pets. I like a "shabby chic" item or two in my home, but by the time my youngest was four all of our furniture had the distressed … [Read more...]
Remove Wax Buildup From FurnitureThis post may contain affiliate links. Your purchase helps support this site. Thank you!
We all love the look of lovely wood furniture polished until it gleams, but after years of using commercial furniture polish, it's important to remove wax buildup from furniture. Why? Because the silicon in commercial polish builds up with each application, often trapping humidity or moisture between layers that eventually makes the surface feel sticky. If the process of removing wax buildup … [Read more...]
Homemade Furniture PolishThis post may contain affiliate links. Your purchase helps support this site. Thank you!
Homemade furniture polish does wonders for your wood furniture by cleaning, moisturizing, and protecting it at the same time. You've probably heard that furniture polish can dull your furniture over time, and that's true about commercial products. The majority of commercial polishes contain silicone, or a silicone substitute, to counteract the effects of other ingredients. But, since silicone … [Read more...]


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§61-3-54. Taking identity of another person; penalty.
Any person who knowingly takes the name, birth date, social security number or other identifying information of another person, without the consent of that other person, with the intent to fraudulently represent that he or she is the other person for the purpose of making financial or credit transactions in the other person's name, is guilty of a felony, and upon conviction, shall be punished by confinement in the penitentiary not more than five years, or fined not more than one thousand dollars, or both:
, That the provisions of this section do not apply to any person who obtains another person's drivers license or other form of identification for the sole purpose of misrepresenting his or her age.


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Dear Members,
Keep in mind that Character Bashing is now prohibited. Making fun of certain characters/character pairings leads to a pointless thread filled with insults and general rule breaking.
Also, remember that Versus threads are allowed only in the Versus section.
Thank you, NarutoBase Staff
Originally Posted by Slug Princess Tsunade
But those list who cant kill her is even more longer
1. The 8O OOO gennin- chuunin fodder
2. Guy, Hidan, Sasori, Konan, Orochimaru, every member of K11, Temari, Kankoro, Mei, A, Gaara, Hanzo, Hiruzen, Danzo ( only with KA), Yagura, etc., etc, etc.
Hmmmmmm... I hope your not calling k11 fodders.
Especially the "head" of the medical squad and we all know who that is now that Tsunade is down.
Forum Rules


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Celeb Style: LeAnn Rimes
LeAnn Rimes walked out of Kushiyu restaurant with boyfriend Eddie Cibrian in a perfect Fall ensemble for a mild LA day. She wore a sleeveless Brochu Walker wrap cardigan with some blue jeans, which she smartly tucked into a pair of tall suede boots, and finished off the look with some aviator shades and a gold pendant necklace. Shop her exact sweater and other similar items now.
Source: Bauer-Griffin Online


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Inquiries will be accepted only via Western Union telegram or rotary phone.
She traveled to South Africa as a rotary International Youth Ambassador and contracted malaria.
It is the biggest gathering of tantric musicians in the world, and makes Woodstock look like a rotary Club dinner.
The thwap-thwap-thwap of rotary wings above triggered an intense reaction in Army trauma surgeon Dr. (Maj.) Tara Dixon.
The Duckman was placarded to indicate that he was representing the rotary Club of Amwell.
Other simple mechanism works a rotary drum by which this indicator card is carried.
It occurred to him that the ordinary engine might be adapted to give the rotary motion.
The contents of the rotary boiler have been emptied upon the floor.
The one who planned it knew that the earth is a sphere and that its motion is rotary.
Steam-engines are of two kinds:— reciprocating, employing cylinders and cranks; rotary, called turbines.
1731, from Medieval Latin rotarius "pertaining to wheels," from Latin rota "a wheel, a potter's wheel; wheel for torture," from PIE root *roto- "to run, to turn, to roll" (cf. Sanskrit rathah "car, chariot;" Avestan ratho; Lithuanian ratas "wheel," ritu "I roll;" Old High German rad, German Rad, Dutch rad, Old Frisian reth, Old Saxon rath, Old Irish roth, Welsh rhod "carriage wheel"). The international service club (founded by Paul P. Harris in Chicago in 1905) so called from the practice of clubs entertaining in rotation. Hence Rotarian (1911).


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Financial Aid, Scholarships, Grants, and Loans
At Rainy River, we know that, even though we keep tuition and fees as low as possible, college costs can present a difficult financial barrier to many of you and your families. To help ease this problem, we make a number of financial aid programs available to you in the form of grants, scholarships, work opportunities and loans.
In fact, over 90% of our students receive some form of financial aid and we award over $150,000 in scholarships annually.
The RRCC Financial Aid Office can help you... * Apply for financial aid * Find information about our policies * Learn about types of aid available * Apply for a student loan
2011 Top of the Class Scholarship Recipients
Financial Aid Contact Information~Financial Aid Rainy River Community College 1501 Highway 71 International Falls, MN 56649 218.285.2205
Email: Financial Aid Director


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Despite the lingering snow piles here in Vermont (and seemingly everywhere else in the country), the long days and the calendar indicate that spring is here. As such, it's time for a little spring cleaning, not just of the closets, but in the kitchen, too. Beyond simply cleaning surfaces, now is the time to go through your pantry staples, check expiration dates on canned and other dry goods and toss anything that's been buried in the back of your fridge. For a handy reference —and for food that might not have an expiration date — here's a list of the shelf life of pantry staples.
Baking Ingredients
Baking powder and soda
Shelf life: 6 months, opened
Storage: Check the shelf life by putting a few drops of vinegar into a small amount of baking soda; if it bubbles a lot, it's still good. This works for baking powder, too.
Brown sugar
Shelf life: 4 months
Storage: Store in an air-tight container or place a slice of orange peel in the box to help keep it soft.
Cocoa powder
Shelf life: 1 year
Storage: Keep in a cool, dry place.
Shelf life: 1 year
Storage: Store it in the freezer to double the shelf life.
Corn Syrup
Shelf life: 3 years
Storage: Keep in an airtight container.
Shelf life: 6 months (opened); 12 months (unopened)
Storage: Keep in an airtight container; refrigerate to extend shelf life.
Spices and herbs
Shelf life: 6 months
Storage: If possible, buy them in small quantities in the bulk section and store them in jars. Also, don't sprinkle herbs into cooking food directly from the jar — the steam will make the herbs go bad faster.
Whole-grain flours
Shelf life: 6 – 8 months (fridge); 1 – 2 years (freezer)
Storage: Always store whole-grain flours in the fridge or freezer, since they go rancid easily.
White flour
Shelf life: 6 – 8 months
Storage: Keep in an airtight container.
White Sugar
Shelf life: 2 years
Storage: Keep in an airtight container.
Brown rice and whole grains
Shelf life: 6 months
Storage: Store in an airtight container
Evaporated milk
Shelf life: 12 to 13 months
Storage: Keep in a cool, dry place.
Canned and Jarred Goods
Canned beans and tuna
Shelf life: 2 – 5 years
Storage: Keep in a cool, dry place.
Canned fruits and vegetables (including tomatoes and tomato sauce)
Shelf life: 12 – 24 months
Storage: Once you open the jar, transfer it to an airtight container and store in the fridge for up to 3 days.
Milk, condensed or evaporated
Shelf life: 12 – 23 months
Tips: After opening, you can keep it for 8 – 20 days in the fridge
Condiments and Miscellaneous
Shelf life: Indefinite
Storage: Keep at room temperature.
Bread crumbs
Shelf life: 6 months
Storage: Keep in an air-tight container.
Dried fruit
Shelf life: 6 months
Storage: They'll stay fresher in the refrigerator.
Shelf life: 6 months (in the fridge); 1 month (unrefrigerated)
Storage: Refrigerate it.
Shelf life: 6 – 8 months (opened)
Storage: Keep it in the fridge once opened.
Shelf life: 6 months – 1 year
Storage: If you live in a warmer climate, consider storing them in the fridge
Peanut butter
Shelf life: 6 – 9 months (unopened); 2 – 3 months (opened)
Storage: Store opened jars of natural peanut butter in the fridge.
Shelf life: 1 year (opened)
Storage: Store in a cool, dark place
Sources: Virginia Cooperative Extension; What's Cooking America?


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PKR to take Bera, Labuan and Setiawangsa
PKR today announced that the party is going to contest in the Bera, Labuan and Setiawangsa paliamentary seats, formerly contested by Pakatan ally PAS, in return for traditional seats that it had to give up to the Islamic party.
For the rest of this story and more, subscribe for only RM150 a year (full news access)
or RM420 a year (full news + full archive access). If you're already a subscriber, please sign in.


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Gurudwara shooting: Badal writes to PM
CM Parkash Singh Badal asked PM Manmohan Singh to take up the issue of safety and security of Sikhs living in America with the Obama administration.
New Delhi/Chandigarh: In the aftermath of the shooting incident at a gurdwara in Wisconsin in the US, Punjab Chief Minister Parkash Singh Badal today asked Prime Minister Manmohan Singh to take up the issue of safety and security of Sikhs living in America with the Obama administration.
Badal, in a letter to the Prime Minister, asked him to talk to the US administration to get the incident investigated throughly to ascertain the truth.
"I have written a detailed letter to the Prime Minister. The US Ambassador to India also called me and I told her about Sikh community`s concerns following the shooting incident," the Chief Minister told reporters in Delhi.
"I have asked for a thorough investigation to ensure that such incidents are not repeated in future," said Badal, who is leaving for the US to meet the bereaved families.
"I will share the grief of the bereaved families by visiting them in the US," he said.
The Chief Minister also called for a comprehensive administrative and social campaign to eliminate the possibility of recurrence of such tragic incidents.
In Chandigarh, Deputy Chief Minister and SAD chief Sukhbir Singh Badal asked the External Affairs ministry to widen its diplomatic response to cover other nations where Sikhs were residing and contributing in a significant way to their progress.
The Chief Minister said "there is a growing feeling in
the minds of Punjabis in general and Sikhs in particular that the Union government must get more actively and vigorously involved in getting the US administration address the issue of safety in right earnest."
In the letter, he said members of the Sikh community had been living peacefully in various parts of the world, including the US, for centuries.
"The tragic incident in the gurudwara is all the more painful and difficult to understand in the background of the outstanding role played by the peaceful Sikh community in the American success story," the Chief Minister said.
Detailing steps required to be taken for instilling a sense of security among the Sikhs, he said "there are two issues that require effective and pro-active response from the government of India."
"The first, of course, is the immediate task of dealing with the aftermath of Sunday`s tragedy.
"Apart from tracking down the culprits and getting to the root of the crime and understanding the dynamics behind it, there is an equally important and urgent need to provide relief to affected families," the Chief Minister said.
Punjab Congress president Amarinder Singh condemned the shooting incident and hoped the US government would punish the guilty at the earliest.
The SGPC, apex religious body of the Sikhs, described the shooting as a condemnable criminal act and urged the Prime Minister to take up with authorities the issue of saftey of the minority community.
In Amritsar, Sikhs from different walks of life met SGPC president Avtar Singh Makkar to express concern over the incident.
They requested Makkar to adopt a constructive line of action to extend help to affected Sikhs in US.
Condmening the shooting, Akal Takht head priest Gurbachan Singh said "this is a security lapse on the part of the US government.
A gunman opened fire inside a gurudwara in Wisconsin yesterday killing six people.


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Perth residents shivered through a minimum of 3.4 degrees this morning but it might be worth keeping those extra blankets on the bed for a while yet.
A few showers across Tuesday and Wednesday will keep minimums slightly above this morning's low point but minimums of 2 and 3 degrees are forecast for Friday, Saturday, Sunday and Monday.
Friday and Saturday are likely to be chilly throughout much of the day- with tops of just 16 degrees.
The temperature is expected to reach 20 degrees today with a mostly sunny morning and isolated showers are likely during the evening.
This week's forecast:
Wednesday 9-18
Thursday 5-17
Friday 3-16
Saturday 2-16
Sunday 3-17
Monday 2-17


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CableTV.com Recommends DIRECTV for your TV service
When choosing a TV service, it's important to understand the difference between the many cable companies and other television services available in your area. Our data from independent consumer surveys helps us make that distinction and shows us that DIRECTV ranks as the best TV service provider among satellite TV or cable companies in Deep Water, WV.
With the extra channels offered in premier TV packages, you'll never have to miss a Pittsburgh Steelers or game or any of your favorite TV shows. It's important to look at the channels offered in a package, since some TV packages in Deep Water offer most of the major networks, but have a different selection of smaller channels compared to similar packages available in other cities. We find the highest rated providers available in Deep Water and give you a side-by-side comparison of all the channels and extra features offered by each company. You'll find the selection of channels and features you're looking for at a price that fits your budget so you can be confident that you're getting the best cable company in Deep Water, WV for your entertainment needs.
CableTV.com has the information you need to find the perfect TV provider. With CableTV.com, every cable company in Deep Water, WV gets a rating and ranking based on its customer service, reliability, and other factors. Check the recommendations at CableTV.com and you're more likely to get a dependable cable provider that offers great customer service.


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Home > Specials > Global Terrorism > Article
The policeman who led the joint Australian-Indonesian bombing investigation, General I Made Mangku Pastika, yesterday said Hambali had dictated the overall tactics for the Kuta nightclub attacks, and helped channel funds for the operation.
But, speaking hours after the arrest was confirmed, and aware of the terrorism alert for this weekend's national day celebrations - General Pastika warned that the threat of further attacks had not diminished with Hambali's capture. An ideological battle was needed to halt the spread of Islamic extremism, he said.
He labelled Hambali "the missing link" in the case and said the arrest provided hope that other fugitive suspects, mainly the bomb technicians, Dr Azahari Husin and Dulmatin, would soon be arrested.
"Hambali was the key person in the Bali bombings," he said.
"This arrest is very significant, but I cannot give any comments about the terrorist threat because it very much depends on a national effort to fight against this . . .
"Fighting against terrorism is not completed by arresting these people. Terrorism is based on ideology, on belief and a radical mind, and we have to work this mind, [work] against this mind."
For the past six months, a joint ASEAN police taskforce, using officers from Thailand, Indonesia, the Philippines and Malaysia, has swapped intelligence on Hambali's possible whereabouts. The Australian Federal Police has had a peripheral involvement.
General Pastika confirmed he always felt Hambali was in exile in the southern Philippines, or Thailand, but would not elaborate on why he held such views.
He said he wanted Hambali to be put before the Bali courts for his role in the attacks on the Sari Club and Paddy's Irish Pub.
But it was too early to know if American authorities would allow his extradition to Indonesia, and further diplomatic talks were required.
Intricate details of the Jemaah Islamiah terrorist organisation's structure, tactics, and recruitment plans have emerged during the Bali bombing trials.
Hambali's name has also cropped up several times, particularly how he was replaced by Mukhlas - the supervisor of the attacks in Jalan Legian - as JI's South-East Asia operations boss.
The most significant evidence came recently from a Malaysian prisoner, Wan Min bin Wan Mat, who said on a video link that he passed $US35,000 ($53,000) to Mukhlas, "possibly" from al-Qaeda sources, for unspecified operations.
General Pastika said he believed Hambali had been the source of Wan Min's finances, and that he was an al-Qaeda regional representative. The funds were eventually passed to Amrozi, and other suspects, to buy chemicals, vehicles, phones, and safe houses.
|Print this article Email to a friend
Global Terrorism
Bali suspects bombed hotel, say police
Malaysia holds Hambali's wife under security law
Terrorists kept tabs on airline: Saudis
Indonesian minister rejects JI link to schools
Hambali to face questions from Australia: Downer
'US likely target of another major terrorist attack'
Hambali had summit in bombsights, and danger is not over
Terrorist mastermind who ran out of places to hide
Nine arrested over Jakarta blast
Arrest may end up breaking JI's hold on Asia
Hambali knows too much to face firing squad, say experts
Fugitive's fall was inevitable: landlord
The terrorist threat remains, warns Bali bombing investigator
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USD Dollar des États-Unis
Amazing stay at a wonderful hotel!
The seating in the breakfast are was too low for an older person as a real effort is required to rise from the table each time you wish to obtain fod or a fruit juice.
A very good and quiet hotel in a good location at a sensible price and very acceptable decor and surroundings
Thank you!
E' un albergo per conoscitori, per chi apprezza un ambiente riservato, silenzioso nel centro di FI. Unica pecca non eliminabile: non c'è ascensore, impossibile installarlo, e le scale sono ripide. Fin che le gambe tengono ci torno.
A portata di passeggio ottime tratto-pizzerie per tutti gli stomachi e tasche, Cibreo incluso.
Camere arredate con gusto sopraffino e letti grandi e comodi.
Vicinisssimo alla shopping area, negozi e mercatini. Musei e mostre da vedere sempre Galileo in testa, Pitti eccetera.
Molto bene e ripeto solo per gente "Educata" e discreta.
Una nota: il personale, sempre lo stesso da anni, sempre cortese e disponibile ripicchia nel comportamento la filosofia dei proprietari. complimenti ancora e a presto.
Hôtel plein de charme. Accueil très chaleureux. Personnel extrêmement agréable.Une jolie cour pour prendre les petits déjeuners en plein air. Un point de départ idéal pour une visite de Florence et de la Toscane.
I think that it would be helpful to have a closet that is NOT on top of a chest of drawers and a safe; I could hardly reach the closet rod. Also, nightables with drawers would be helpful. Otherwise, we were very happy with the facilities.
A lovely hotel which is better in reality than on the web. Very welcoming staff. We would happily return.
Ottima struttura situata in posizione strategica. Camera e bagno grandi e confortevoli. Personale molto cortese. Atmosfera tranquilla e riposante. Unico neo: la mancanza di parcheggio rende quasi obbligatorio il servizio di parcheggio a pagamento (comunque molto comodo con servizio di ritiro e consegna direttamente in hotel).
Room #1 on the ground floor was quite special in that it was 2 floors- unlikely that the 2nd floor will be used but creates more atmosphere which we liked.
Pleas put my Northwest Airlines (Delta) World Perks number in you would. NW 925 000 705 Thank you and we had a great stay. Jerry Joy
Price quality ratio is bad.There were not enough comforts for the price of our suite. No lift,very nice, but old doors, bathroom, windows,central heating...
Excellent hotel : rooms, service, location. Great place.
We had a great time at your hotel and will definitely be back! The accomodations are beautiful and the service was impeccable. The concierge arranged museum tickets in advance and gave us great directions around the city and into the chianti wine region. Thanks again! - Mike D., New York, NY
The room was very nice, comfortable, elegant, silent.
The bathroom big, nice, comfortale.
Ammeities quite good too.
The only negative comment: we couldn't use internet while staying there (loss of connection).
All in all, an excellent hotel.
The hotel is a real gem, with its small size, history, small size and spendid staff. I have been a guste three times at the hotel. I am happy that these small, individual and familiar hotels still exists in a world of more and more of standardized, monotounos and unpersonal hotels, taken over by chains. Hence, please keep this gem as it is!
With all the best and warmets wishes
Soundproofing very poor in rooms. A real problem if you get noisy or inconsiderate neighbours.
La realtà della struttura è senz'altro superiore a quanto deducibile dalla documetazione fotagrafica disponibile sui vari siti.
Rooms are nice but quite different one from each other. Ours was great and very comfortable. Great Value for Money and very nice staff. Good location and parking possibilities.
Un gros effort est à faire au niveau du nettoyage des chambres qui était très approximatif.
Le reste des services était correct.
Everything was perfect except the breakfast especially having in mind 4 stars hotel rating.
This is the second time that I have stayed here and will now be the only place I stay when visiting Florence. It really feels like my own tuscan villa, and I am so much at home there. Miss it already.
My friend and i had a very pleasant stay at the hotel. The staff you have are exceptionally helpfull and very friendly. I will definately be back with my husband one day
kind regards
The heat worked just in the morning and in the evening. As a consequence during the night it was very cold and we've got a cold! Very bad cold.
It is normally easy and very important (even for romantic couples) to have possibility of Internet on the rooms. Would be nice to see J&J extend the router and wifi point to reach the rooms also :-)
Laissez vos commentaires


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- This and that about flower bulbs
- Transporting flower bulbs
- The history of the bulb
- Growth and Flowering
- Flower bulb project
- Fun with bulbs
- Classroom/house decorating
- Decorate your playground
The Flower Parade
Every year during the third week in April, the Flower Parade is organised by the bulb-growing region as the highlight of the flowering season.
This parade features floats decorated with flowers and the route runs from Noordwijk to Haarlem: a distance of 40 kilometres.
It's with good reason the flower parade is called 'the face of spring', because no other parade measures up to the unique spring colours and fragrances that this entails.
Would you like to know more? Go to: http://www.bloemencorso-bollenstreek.nl/index.asp?lan=en


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Editors at Custom Home gathered a collection of new kitchen products. Many of them fit the trends predicted by experts at this year's KBIS:
Technology is making appliances and other home products both "fun" and "smart." And the recent industry-wide push towards sustainability suggests that a melding of the two should yield efficient and attractive designs that help consumers manage their households.
Sure, attendees are hot for high-end products. But affordable design is surfacing as a way to remodel while remaining innovative and budget-conscious.
- The popularity of recyclable and engineered materials is closing in on traditional surfaces like granite.
Plus, universal design takes on new importance as designers and manufacturers begin to better understand and serve a market with highly diverse needs and varying abilities.


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Ask an Eye Doctor and Get an Answer ASAP
Hi. I'm online and happy to answer your question today.
do you know the extent of the retinal detachment? Is your macula (the central part of your retina that is used for every day visual tasks) detached already?
Do you mean to say that your macula is involved?
dont know, but dr said it was detached big time
Ok. Well, retina is what I do and have been doing for almost 2 decades. I lean strongly toward the side of repairing the retina. If you do nothing you will, for sure, go lights out blind in that eye and, just might, end up loosing the entire eyeball. You have gone through too much with the corneal transplant to give up now :)
what is my recovery time for returning to work, in a rock quarry? and what is the recovery procedure?
What do you do in the rock quarry?
load dump truck and haul rock ,mildly dusty
This is big surgery as far as eyes goes. There are a number of different surgical approaches to repairing your detachment. From what you stated it sounds like your doc is planning on a vitrectomy/gas-fluid exchange with endolaser.
Being in a heavy dump truck is kinda bouncy.....I'd probably say you should stay out of that truck for 4 weeks or so, depending on what type of surgery your doc does and how well you heal.
what does the recovery procedure involve
If you have a eye full of gas after the surgery you may have to position your head in a certain way while the gas is present. Depending on the gas used (SF6 or C3F8) that might mean 4 or 5 days or a few weeks. You will have to use drops (much like you are doing/did after your graft) and keep from any heavy lifting or bending while the laser "welds take"
This is, of course, all variable on what is found during the surgical repair or your retina, what combination of surgical techniques are used and how things go after the surgery.
Does this make sense to you?
yes, thank you
My pleasure. Best of luck in your upcoming surgery. It sounds like you are in good hands.
And, now, the obligatory word from our sponsors: :o)
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