text:
Assessment of Efficacy of AZD2281 in Platinum Sensitive Relapsed Serous Ovarian Cancer
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: September 12, 2008
Last updated: February 6, 2013
Last verified: February 2013
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Tracking Information
|First Received Date ICMJE
|September 12, 2008
|Last Updated Date
|February 6, 2013
|Start Date ICMJE
|August 2008
|Primary Completion Date
|June 2010 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Progression Free Survival (PFS) (According to Response Evaluation Criteria in Solid Tumours [RECIST]) [ Time Frame: Radiologic scans performed at baseline then every 12 weeks (+/- 1 week) for the first 60 weeks, then every 24 weeks (+/-1 week) thereafter ]
PFS was defined as the time from randomisation to the earlier date of radiological progression (per RECIST criteria) or death by any cause in the absence of objective progression. [Full analysis set (FAS)]
|Original Primary Outcome Measures ICMJE
|The primary objective of this study is to determine the efficacy (assessed by progression free survival [PFS]) of AZD2281 compared to placebo in this patient population [ Time Frame: Radiological tumour assessments will occur every 12 weeks ]
|Change History
|Complete list of historical versions of study NCT00753545 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Assessment of Efficacy of AZD2281 in Platinum Sensitive Relapsed Serous Ovarian Cancer
|Official Title ICMJE
|Phase II Randomised, Double Blind, Multicentre Study to Assess the Efficacy of AZD2281 in the Treatment of Patients With Platinum Sensitive Relapsed Serous Ovarian Cancer Following Treatment With Two or More Platinum Containing Regimens
|Brief Summary
|The primary purpose of this study to determine if AZD2281 is effective and well tolerated in maintaining the improvement in your cancer after previous platinum-based chemotherapy.
|Detailed Description
|Not Provided
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Condition ICMJE
|Ovarian Cancer
|Intervention ICMJE
|Study Arms
|Publications *
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Completion Date
|November 2012
|Primary Completion Date
|June 2010 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|Australia, Belgium, Canada, Czech Republic, Estonia, France, Germany, Israel, Netherlands, Poland, Romania, Russian Federation, Spain, Ukraine, United Kingdom, United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Study Sponsor ICMJE
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|Verification Date
|February 2013
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Purple Acrylic Tapers
$5.99 $3.00
Please fill in the form below if you'd like to be notified when it becomes available.Notify me when available
What is it?
Cheap and colorful, Acrylic serves a purpose. Not recommended for everyday wear.
Product Details
What is it made of?
Material: Acrylic
Wearable Area: Coming soon
Class: Acrylic
Color: Purple

subset: commoncrawl


text:
Tricky genus to figure out. Here's the key if you want to take a stab at it.
Yes it is, I'll give it a shot and see what comes of it.
The data quality assessment is a summary of an observation's accuracy. All
observations start as "casual" grade, and become
"needs ID" when
Observations become "research grade" when
Observations will revert to "casual" if the above conditions aren't met or the community agrees
And if that wasn't complicated enough, there are also situations where the system gets a vote:
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text:
Twelve Days in Persia: Across the Mountains with the Bakhtiari Tribe
Christopher de Bellaigue writes:
Vita Sackville-West went twice to Persia because her husband was on a posting there, and while there was never any suggestion that she would exchange her glittering English existence to keep house at the legation, she went without compulsion, because she missed him. This, her second trip, would take her among some of the wildest inhabitants of Persia, the Bakhtiari tribe – whose origins, lost in antiquity, remained (and remain) the subject of romantic speculation. And if, after getting home, she is 'loath to let the whole thing go unrecorded', it is less that she has valuable new information to impart than that she sees her own life as a necklace of epiphanies, each one important, each one asking for recognition. She will 'clap the net over the butterfly of the moment'.


text:
George Nooks
Sting - Keeling Reggae
Get your groove on with 60,000 fans in this concert film featuring highlights from Sting, Jamaica's premier reggae festival, including hot performances from Beenie Man, Merciless, Bounty Killer, Junior Kelly, George Nooks and Ninja Man. Still not enough? No problem. Other acts captured in this unforgettable reggae extravaganza include Alozade, Vegas, Hawkeye, Lexxus and many more.


text:
Your Significant Other Is Left Off a Wedding Invitation. What Do You Do?
Readers say:
Bring it up directly with the bride: 46.6%
Say nothing and attend the wedding solo: 44.3%
Return the RSVP with your significant other's name written in: 9.2%
Experts say: "A bride who has spent months obsessively editing her guest list may beg to differ, but from an etiquette standpoint, it is OK to ask. Just be prepared to hear that your partner can't be included," says Elise Mac Adam, a wedding-etiquette authority and the author of Something New ($15, Simon Spotlight Entertainment, amazon.com). And, no, never just write an extra person's name on the response card.


text: Editor's note: Adam Feuerstein will be the featured guest on TSC Live at noon EDT Tuesday, Sept. 29. Send him your questions by: Emailing us at email@example.com; posting them on our Facebook page, facebook.com/thestreet; Tweeting us @thestreet_news with #tsclive; or posting them on the live show page in the comments section. Bookmark the TSC Live page now. SAN FRANCISCO ( TheStreet) -- Cytokinetics ( CYTK) traded sharply higher during Friday's session with gains coming on heavy volume following rumors of a possible acquisition by Amgen ( AMGN). Cytokinetics saw 2.5 million shares change hands Friday, many times greater than the 50-day average daily volume of 418,000 shares, after Briefing.com reported market chatter of a possible deal that would see Amgen acquire the small-cap biotech company. Volume was greatest during the 2 p.m. EDT hour, when Cytokinetics' stock hit an intraday high of $5.20, close to its 52-week high. Shares were lately up 55 cents, or 12.3%, at $5.03. Cytokinetics has a 45.3 million-share float with a small short interest float of 2.2% as of Aug. 26, according to Yahoo! Finance. Amgen, on the other hand, has a float of one billion and a short interest float of 2.2%. Amgen has a market cap of $61.5 billion, compared to Cytokinetics' $303 million market cap. Cytokinetics shares are poised to finish the week with an advance of more than 25%. On Monday, the stock popped after a Wedbush Morgan analyst increased the firm's price target to $18 from $4, citing the company's focus on drugs that improve muscle function. Investor posts on Internet message boards Friday argued that Cytokinetics is undervalued, given the company's potential when compared to other biotech companies. Others noted that rumors of a partnership with Amgen first popped up a few months earlier. Some traders pointed out that the stock is now only back to trading where it was a year ago. -- Written by Robert Holmes in New York.


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Yes..today is the day! I have spent the morning in Central Park and Battery Park taking photos..so much to see here.
In a couple of hours we will be having our interviews with some of the actors from Marvel's The Avengers!
I have so many photos and stories to write and post once I get home….so excited!
– Posted using BlogPress from my iPad
Location:Eventi Hotel, NY
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Girl on Fire
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Brandy is the wife to a carpenter/musician and the mother of 3 amazingly awesome homeschool/unschooled girls. Brandy is a Photographer as well as a Coach for the Weebellion as part of Rolling Rebellion Jr. Roller Derby. Brandy is passionate about many things and suffers from a very painful and degenerative neurological disease called CRPS/RSD.
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|Freelancers 2
Share |
Harvey Rachlin
Anything else editors should know about you: I have written 13 books on a variety of subjects. One of my books, "Lucy's Bones, Sacred Stones, and Einstein's Brain," was adapted for the long-running History Channel series, History's Lost and Found. I have also written hundreds of articles. However, my passion is to write quirky Jewish personal essays. These essays range from humorous to serious and may provide a diversion from the usual heavy international and local news of Jewish newspapers. They may be suitable for the "Opinion" page or as essays that stand alone as features by themselves. Ideally, I would like to have a column in a Jewish publication and I could provide essays on whatever basis a publication would like—weekly, bi-weekly, monthly or occasionally, and they could be of any length desired.
Red & Black (Sisters Tina Pennington and Mandy Williams)
Email: email@example.com, email@example.com
Your website/Facebook page:
Website: www.RedandBlackbooks.com
Twitter: https://twitter.com/RedBlackReal
Anything else editors should know about you: Authors of the best-selling book, "What I Learned About Life When My Husband Got Fired!" Launched by internationally renowned retailer Neiman Marcus, our self-published book soon rose in popularity as a textbook (approved by the Texas State Board of Education) and course on personal finance and Life 101. From those humble beginnings, the "Red & Black" phenomenon has gained exceptional market appeal. Every speaking engagement brings clamor for more – books, columns, articles, videos – as our message is about personal accountability. Self-esteem grows as audiences across all socio-economic strata embrace the simple concepts and begin to own their future.
Adam Reinherz
Email: firstname.lastname@example.com
Favorite topics to write about: Obituaries, running and endurance athletics.
Media outlets that run your work: The Jewish Chronicle and JUF News.
Anything else editors should know about you: I like to write obituaries. I also like to run and hope that running isn't the end of me.
Bryan Rigg
Email: email@example.com
Media outlets that run your work: Numerous newspapers, numerous TV shows, numerous magazines. For example, The London Telegraph, LA Times, NY Times, NBC Dateline, etc.
Leni Reiss
Email: firstname.lastname@example.com
Ted Roberts
Email: firstname.lastname@example.com
Website: http://www.wonderwordworks.com, http://www.scribblerontheroof.typepad.com
Favorite topics to write about: I like to write about biblical conundrums, Jewish customs, food and Israel.
Media outlets that run your work: New York Times, Wall Street Journal, Boston Globe, Disney magazine, Hadassah, Memphis Commercial Appeal, Crescent City Jewish News, Nashville Tennessean, Huntsville Times, Rochester Ledger, Memphis Hebrew Watchman, Wall St. Journal and Jewish web sites– National Jewish Post and Opinion, Think Israel, Jewish Magazine, and Jewish Week.
Anything else editors should know about you: My treatment of Jewish themes attempts to be insightful as well as lighthearted. I am not a reporter but more of a commentator and observer of this weird world. I have been published in the Jewish press as other publications since mid-1980s. I am a Rockower Award winner.
Email: email@example.com
Favorite topics to write about: Pirke Avot: Without bread there is no Torah.
Media outlets that run your work: Los Angeles Jewish Journal
Peter Rothholz
Media outlets that run your work: JNS.org, Long Island (N.Y.) Jewish World, Manhattan (N.Y.) Jewish Sentinel, Rockland (N.Y.) Jewish Tribune, Jewish News (London),LA Blueprint, Santa Monica Daily Press and The Cutting Edge News (online magazine).
Anything else editors should know about you: For more than 40 years, I operated my own New York City-based public relations agency. Among our clients were several foreign governmental agencies ( including Barbados, Israel, Italy and New Zealand) as well as U.S. and foreign corporations.
Debra Rubin
Email: email@example.com
Website: http://www.linkedin.com/pub/debra-rubin/0/981/23
Media outlets that run your work: My work has appeared in JTA, JNS, Times of Israel, Religion News Service and Jewish publications nationwide.
Anything else editors should know about you: Backed up on editing or proofing? Ask me.
Email: email@example.com
Favorite topics to write about: Jewish affairs, history, politics.
Media outlets that run your work: Atlanta Jewish Times Forward
Anything else editors should know about you: Diane J. Schmidt is an internationally published and award-winning writer and photojournalist. In 2015 she won first-place for News and for Photography in the AJPA Rockower Awards for the New Mexico Jewish Link for coverage of the BDS movement, and first-place for Reporting: Education for "The Navajo Long Walk and the Holocaust," and second for personal columns (-from the Jewish perspective-) in the Society of Professional Journalists Top of the Rockies for the Gallup Independent; has served as board member of the NM Jewish Historical Society, New Mexico Press Women, and Society of Professional Journalists Rio Grande Chapter, and is a New America Media Journalist-in-Aging Fellow, 2015, a Robert R. McCormick Poynter Institute Fellow 2012, and a National Endowment for the Arts Visual Arts Photography fellow, 1986. For her coverage of a swastika-branding hate crime of a Navajo in New Mexico, Schmidt received a public safety award from the Arizona Press Club and first-place, News, Native American Journalist Association. In the last few years she has received 2 first-place and one second-place awards from the Society of Professional Journalists Top of the Rockies competition for Education reporting, radio commentary, and personal columns. She started out as a photojournalist in Chicago, received a National Endowment for the Arts Visual Arts Fellowship for her photo essays on the city at night published by the Chicago Tribune Sunday Magazine, and was an American Society of Media Photographers board member there. Early on, covering the civil war in El Salvador as a photojournalist informs her writing today. Twitter: @dianeschmidt22. website:http://www.dianejoyschmidt.com Diane has a M.A. English/Creative Writing, University of New Mexico; B.F.A. Photography, Rhode Island School of Design;and B.A. Comparative Literature, Prescott College, AZ
Diane J. Schmidt - email@example.com
Penny Schwartz
Email: email@example.com
Helen Zegerman Schwimmer
Your website/Facebook page: www.Helenschwimmer.com
Media outlets that run your work: The Jewish Press, Wisconsin Jewish Chronicle, Dayton Jewish Observer, Arizona Jewish Post, Jewish Journal of Greater Los Angeles, Jewish Herald Voice, Jewish Advocate, Cleveland Jewish News, Jewish News of Greater Phoenix, and Boomercafe.com.
Anything else editors should know about you: Public relations and media consultant to:
Phyllis Singer
Email: firstname.lastname@example.com
Robert A. Sklar
Email: email@example.com
Max Sparber
Email: email@example.com
Tom Tugend
Email: email@example.com
Jane Ulman
Email: email@example.com
Email: firstname.lastname@example.com
Your website page: http://www.amuseum.org
Anything else editors should know about you: I had my first article published in Numismatic Scrapbook Magazine in 1967. Since then my articles on coins and medals, almost all on Jewish subjects, have been published in virtually every United States numismatic publication. These have ranged from scholarly articles, such as "Gershom Mendes Seixas, The First American Jewish Medal" in Issue No. 54, 2009 of The Medal, to general articles like "Is Charles Steinmetz, Electronic Genius, Eligible for the Jewish-American Hall of Fame" in January-March, 2015 issue of The Shekel. I have also written virtually all of the text on the Jewish-American Hall of Fame's website www.amuseum.org, that includes my "Handbook of Biblical Numismatics," written originally in 1976 and periodically updated.
Email: email@example.com
Dina Weinstein
Email: email@example.com
Your website page: https://dinaweinstein.wordpress.com/
Favorite topics to write about: Books, authors, Jews and civil rights, food, history, women, trends, travel, education, the Southern Jewish experience.
Media outlets that run your work: B'nai Brith magazine, JCC Circle, Jewish Book World, Florida Book Review, Teaching Tolerance, Tablet, Jewish Daily Forward, The Miami Herald, South Florida Parenting, Southern Jewish History and JTA.
Anything else editors should know about you: Dina Weinstein is a Miami, Florida-based journalist who enjoys writing about books, authors, food and Jewish trends. She mentors young journalists as an adviser at the Miami Dade College student newspaper The Reporter. Weinstein has taught journalism and mass communications at a number of colleges including Miami Dade College. She is a Boston native and a graduate of Columbia University Graduate School of Journalism and Boston University School for the Arts. With a grant from the Southern Jewish Historical Society, Weinstein is researching Jews in St. Augustine, Florida, during the 1960s civil rights struggle there.
Mark Zimmerman
Email: firstname.lastname@example.com
Your website: http://www.rrrjewishtrivia.com/
Favorite topics to write about: Jewish Trivia
Media outlets that run your work: Crescent City Jewish News, Sh'ma Journal and San Diego Jewish World
Anything else editors should about you: I write Jewish Trivia quizzes that are educational and humorous. I can also create custom quizzes on a specific Jewish topic of interest.


text:
Taylor in line for La Dispute
posted Sunday, February, 10th 2013, 8:00pm
A drunk couple noticed you were alone and so was I so they pestered you to talk to me. They teased you about your "bieber haircut" and I smiled. You said your name was Taylor and I just said hi. You were way too cute for me to say anything else. I lost you once we got inside. Can I make it up to you at the next concert? -Sophia
When: Saturday, February, 9 2013
Where: Vogue Theater lineup


text:
DG Justice and Consumers
DG Education and Culture
DG for Research & Innovation
DG Communications Networks, Content and Technology
The objective of this Kit is to provide you with pedagogical resources and interactive tools to use when teaching your students about this topic.
This year's Inter-School Competition is based on the theme of 'Energy'. To help create your project, you can download the Energy Kit which details lessons and activities for your students. Get started here!
Consumer Classroom is a community website for teachers bringing together an extensive library of consumer education resources from across the EU, along with interactive and collaborative tools to help prepare and share lessons with students and other teachers.


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About the Book
"Colin Livingston - Artist" is the latest Plus Gallery publication to offer an in-depth view of one of the gallery's most outstanding, celebrated contemporary artists. The book covers Livingston's last three solo exhibitions from between the years 2006 and 2013, ones that have engaged the gallery context in a most extraordinary fashion, presenting conceptual painting-based installations where the underlying message is distinct and multi-layered. Livingston has long been hailed as a pop-based painter, generating some of the most visually stimulating, dense compositions of any artist under the age of 40 in the country. There is much more than meets the eye within his work, a challenge to consumer sensibilities as well as a celebration of today's unique systems which the consumer has mandated. Livingston engages the very notions of art as a commodity, presenting an often tongue-very-in-cheek mentality and aesthetic that is both intellectual and fun. The book is the fourth in a series of quality monographs produced by Plus Gallery to celebrate the prominent artists whose careers began in Denver, Colorado. Others in the series include the first two comprehensive publications on the celebrated painter Jenny Morgan "New Territory" and "We are all setting suns, " as well as "Xi Zhang - Dream Dust," all of which are available through Blurb.com
Find out more about Plus Gallery and our artists by visiting plusgallery.com
Features & Details
- Category Arts & Photography
Standard Portrait, 7.75×9.75 in, 20×25 cm
184 Pages
- Publish Date Dec 11, 2013
- Language English
- Tags contemporary art, conceptual art, Denver artists, Plus Gallery, Colin Livingston, pop-painting
About the Creator
Plus Gallery is a long-standing progressive contemporary art program operating in Denver, Colorado. Since 2001 the gallery has built a formidable reputation as a valuable resource for the art and collector community through solo exhibitions by some of Colorado's most prestigious and forward thinking artists, as well as an ongoing experimental forum for new media. The program offers an extensive selection of works by visionary national artists and often serves as an incubator for new emerging talent. Plus Gallery collaborates with partners throughout the Denver area in order to raise the vitality of the local scene, complementing the efforts put forth at the institutional level in order to construct a more creative and dynamic community.
Log in or create an account to post a comment.


text:
WWE has not dragged their feet in the wake of their annual Super Bowl-level show, Wrestlemania 28 by bringing former WWE and UFC Champion Brock Lesnar back to the fold to challenge John Cena. The main event match will go down right here in Chicago under shadows of 747 airliners at the Allstate Arena at Sunday, April 29th at Extreme Rules. There are several other big matches announced for the show including hometown hero CM Punk in action. Here is a preview of the announced matches for the show. If your going to the show, tweet me your thoughts about the show @kevkellam
Extreme Rules Match: Brock Lesnar vs. John Cena
Lesnar shocked the WWE Universe and sent rumbles through UFC fandom, with his epic return to WWE on the night after Wrestlemania. With no words and a Miami crowd jumping out of their seats, the former UFC Heavyweight Champion passed off on shaking hands with John Cena and slammed him with an F5. Lesnar's reported deal with WWE currently has him working a limited amount of dates over the next year with a hefty price tag of around $5 million dollars attached to his work. Unlike dragging the eventual fight between Lesnar and Cena out like WWE did with the Rock and Cena, they are burning up a feud between the two mega-stars as quickly as possible. For the most part, Lesnar has bested Cena in each of their confrontations including bloodying the 10 time WWE Champion which is rare in today's WWE. Lesnar has the advantage, and Cena needs to win this anything-goes match especially after his huge lost to the Rock at Wrestlemania 28. This match is also intriguing as it's Lesnar's first WWE match in 8 years.
WWE Championship Chicago Street Fight: CM Punk vs. Chris Jericho
Though the Extreme Rules Pay Per View is being sold with Lesnar vs. Cena, this match built around the manipulative Jericho attacking WWE Champion CM Punk's straight-edge lifestyle and his family's past issues with substance abuse. Punk has been humiliated by Jericho who poured whiskey on a vulnerable Punk, and smashed the bottle on his head. Punk wants revenge on the sacred stage of his hometown Chicago and his family int he front row. Jericho is playing up the controversial issue of Punk possibly breaking his no alcohol on this week's past RAW in London. On RAW this coming Monday, we should get more rage from Punk and mind games from Jericho. With the Street Fight rules look for the match at Extreme Rules to be a wild outside-the-ring brawl with Punk's family playing a role.
World Heavyweight Championship 2 out of 3 Falls Match: Sheamus vs. Daniel Bryan
Daniel Bryan may have been squashed at Wrestlemania in 18 seconds with his diehard internet following turning on WWE, and turning his catchphrase 'YES!' into a new fun chant. The Celtic Warrior Sheamus may be the new World Heavyweight Champion but a majority fans are not buying the big Irishman even with him pitted against the hated General Manager John Laurinitis on Smackdown in the past few weeks. Bryan has vowed to not have another "fluke" in Chicago at Extreme Rules, and promises to make Sheamus tap out to his neck-cranking 'Yes Lock'. If the two other main events are underwhelming, this will be the match that fans walking out of the show will be talking about.


text:
Four U.S. senators want Facebook to make it easier for its more than 400 million users to protect their privacy as the website develops new outlets to share personal information. It marks the second time in the past three days that Schumer has expressed his misgivings about a series of changes that Facebook announced last week. The new features are designed to unlock more of the data that the online hangout has accumulated about people during its six-year history.
Schumer sent a letter Sunday to the Federal Trade Commission calling for regulators to draw up clearer privacy guidelines for Facebook and other Internet social networks to follow. The political pressure threatens to deter Facebook's efforts to put its stamp on more websites, a goal that could yield more moneymaking opportunities for the privately held company. Facebook's expansion "raises new concerns for users who want to maintain control over their information," the senators wrote in their preliminary draft.
(Source: AP)
Full story
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The information presented within this blog comes from various organizations around the world. ITU encourages users to seek more detailed information from the original source through the links provided.
Links to third-party websites are provided for the convenience of all users. The ITU is not responsible for the accuracy, currency or the reliability of the content on these third-party websites. ITU does not offer any guarantee in that regard nor does ITU endorse the third-party organizations, their sites or content.


text:
Coffee Grounds
Create an exfoliating body scrub, says Kayla Fioravanti, owner of Von Natur, a line of natural skin-care products. Topical caffeine also temporarily widens the blood vessels, which improves circulation.
Mix 2 tablespoons of wet grounds, 1 tablespoon of fine salt, and 2 tablespoons of olive oil, then massage the mixture onto the skin in a circular motion.


text:
Product 4/8
Born in 1962 in Brazil, Havaianas embody the energy and passion of one of the most exciting countries in the world, keeping feet happy for 50 years with hundreds of colorful, fun designs and the highest quality rubber.
This is by far the most iconic design from this hugely recognisable brand. It's made with extra padding to the sole for added comfort, tough and durable rubber to make sure you're not buying another pair next year and comes with all the added aesthetics on the foot strap for a more customisable look.


text:
Northern Maine Medical Center, Fort Kent
Posted Aug. 25, 2011, at 7:50 p.m.
To Jacob and Margaret Guimond of Fort Kent, a daughter, Simone Via, Aug. 16, 2011. Maternal grandparents are Vincent and Monica Cote of the Bangor area. Paternal grandparents are Paul and Joanne Guimond of Fort Kent.
To Daniel and Gina Daigle of New Canada, a daughter, Adaline Mada, Aug. 17, 2011. Maternal grandparents are Rodney and Vicky Ouellette of St. John. Paternal grandparents are Robert and Cheryl Daigle of New Canada.


text:
His head was covered with a blue hoodie rather than a helmet, and his participation was limited to conditioning drills on the sideline.
But after staying away from voluntary organized team activities for three weeks because of his contract situation, Rams defensive tackle Aaron Donald returned to Thousand Oaks and was on the field Tuesday for the start of a mandatory three-day minicamp.
"There's no more news in terms of the contract negotiations," coach Sean McVay said, "but it's great to have him here."
Donald, a three-time Pro Bowl selection, wants a new deal befitting a player who has 28 sacks and is generally recognized as one of the most disruptive defensive forces...


text:
|You are in: Business
Tuesday, 14 May, 2002, 12:31 GMT 13:31 UK
Pakistan renews Afghan duty-free trade
Goods arriving at Pakistan's ports destined for land-locked Afghanistan can again be transported across the country duty-free, the government has said.
The practice, known as transit trade, was always controversial as many products were smuggled back across the Afghan border for sale in Pakistan.
The terrorist attacks in the US on 11 September prompted the Pakistan government to abandon the agreement.
Now, after promises from the Afghan government to crack down on smuggling, the trade is to resume despite evidence the administration has little control over many regions along the border.
Transit trade will be allowed from Port Qasim and Karachi port to Afghanistan.
Imposing authority
The Afghan government has said it will "use all means" to reduce smuggling back into Pakistan, a practice that leading Pakistani author Ahmed Rashid described as the largest source of income for the ousted Taleban government.
But the Afghan administration could have difficulty controlling the movement of goods back across the border.
Afghan warlords continue to rule much of the countryside, taking taxes meant for Kabul, despite the best efforts of the government to impose its own authority.
Afghan customs officials say of the estimated $6m custom duties collected across the country each month, only $200,000 reaches the capital.
The rest is thought to end up in the pockets of Afghan warlords.
Meanwhile, the Afghan government is asking the international community for billions of dollars of aid to start rebuilding a country that has been devastated by 20 years of war.
See also:
21 Mar 02 | Business
Afghanistan's new economic start
21 Jan 02 | Business
Totting up the bill in Afghanistan
13 Nov 01 | South Asia
Afghan neighbours look to the future
28 Sep 01 | South Asia
Eyewitness: 'Heat, dust and desolation'
19 Sep 01 | Business
Afghan economy fights for survival
Internet links:
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Top Business stories now:
Links to more Business stories are at the foot of the page.
Links to more Business stories
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text:
Report from interviews for the Making Great Illustration book. For more info see About
I travel on Eurostar and stay in the centre in a swish hotel. I've not been to Brussells for years and have an explore in the last of the evening sun. It's not very sophisticated but I can't resist having a huge ice cream from an up market chocolate shop. There's not a sprout in sight.
I know that reaching the village where Kitty lives could be a faff; I have to get a metro, and two trains. This is one of the last interviews and I don't want any thing to go wrong so I am up at the crack of dawn and feel a bit frazzled.
When I arrive in the little village where she lives it is still early and Kitty is eating grapefruit in her warm kitchen. She too is warm and makes me feel very at home. We both drink tea in big cups and Kitty talks about her recent prize (the Astrid Lindgren Memorial award 2010) I know it's not polite to ask about money, but I can't help myself from wondering about what it's like to be given almost half a million pounds. She is very humble about it and says that it will give her some freedom and the chance to buy a house of her own. She tells me a story about one of her sons inventing other prizes that she thinks she should be awarded and although I can't remember the details the jist of it is that she realises it's not an excuse to get a big ego.
What is most memorable is the way that Kitty giggles as she speaks, whilst rolling up her own cigarettes. We sit in her big loft studio with the roof windows open and the sound of the birds outside is quite astounding.
It may sound condescending or corny to say that Kitty is charming but really she is. I find her quite magical. When she talks about her visits to Norway during her childhood and her interest in folklore it is easy to imagine her in some mystical landscape, it seems to be where she belongs with her cast of creatures. I'm not surprised when she muses about using some of her prize money for that same purpose. No sprouts there either but more chance of encountering the witches and other ethereal beings in which she believes.
Jo Davies
Photography by Paul Duerinckx
Kitty Crowther publisher site


text:
I have four or five users complaining of random PPTP disconnects when
connecting from XP to the m0n0wall's built in VPN server. The
login-logout logs confirm it, but I wouldn't mind more information, like
if the server or client dropped the connection. How can I dig up more?
- Nick


text:
Warning: This is not just another opportunity. If you want to join the New Rich and get out of the 9 to 5 grind, keep reading and find out exactly how thousands of people are becoming FINANCIALLY FREE.
Re: You Creating Your Future
From: Christopher Seder
Dear Aspiring Real Estate Investor,
Right now there are real estate investors making thousands of dollars each month. These real estate investors are flipping houses without their own money, without credit and some have Zero experience. We are currently in the biggest housing crisis our country has ever seen.
I'm going to unveil some of the most closely guarded secrets the top real estate investors want to keep quite. They are closely-guarded secrets that will revolutionize your beliefs about what is truly possible in the world of real estate investing.
Most investors using these secrets are making so much money they do not want any competition. I am here to share with you real proven methods every day people are using to make $5,000, $10,000 and even $30,000 in less than a month. I know beginning real estate investors making more money in one month than they had made in the past year.
The best part about it all is that you can get started with very little money.
By using the methods I am going to teach you, you will be able to blow your competition out of the water….amazing everyone who comes in your path.
I know what you thinking right now, you have probably heard it all. Everyone is claiming to have the secret to real estate success. A lot of these people know what they are doing and are viable options. Heck I have spent over $10,000 educating myself on real estate investing. Just last year I spend $3,000 on a real estate investing course that changed my life.
My name is Christopher Seder and I want to share with you some of the strategies I used to make $13,000 on my first real estate investing deal.
I started out in real estate investing in the summer of 2009, right after I had graduated from college and realized there were no jobs to be found. I went to work for my father who has been doing real estate for 30 years now. I worked as one of his handy men, fixing rentals and painting houses.
It was not the glamorous job I had planned on getting fresh out of college.
I had a goal; to learn what real estate investing was all about. Even growing up with a father who had several rentals, and flipped several houses a year I didn't even know what a mortgage was.
Yes, I knew nothing about real estate investing at all. The most I had even done growing up was paint a rental or two during the summer. What I did know was that real estate investing had put me and my sister through college and gave my family thousands of dollars in passive income every month.
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As you can see we may or may not be at the bottom. Some areas in the U.S. are starting to see growth while others are still falling.
According to RealtyTrac, home repossessions will rise in 2011 from the record one million homes that were repossessed in 2010. There are five million homeowners who are at least two months behind on their mortgages, primarily due to job losses and declining home prices, which pushes more borrowers underwater.
Who is going to help these people? I am, other investors are and You can too.
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To Your Success,
P.S. Remember, this is a special offer and the price will Go up From $47 to $97 very soon. Do not miss out on over $600 worth of bonuses. Profit from Probates, all of my contracts and marketing material will be gone soon.
P.P.S If you want to stop working 40 hours a week making just enough to afford your monthly expenses, and want the freedom in your life to spend time with family, friends, hobbies, and pretty much do what you want. There is no better way for you to achieve that than to learn the Secrets to Flipping Houses.


text:
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text:
Newcastle have already lodged a £10 million bid with Barcelona for Brazilian star Rivaldo while Liverpool have stolen a march on everyone else by agreeing terms to sign two of the early stars of the finals - Senegal pair Salif Diao and El Hadji Diouf - for a joint fee of £15m.
There is no doubting the talent. It is just a case of judging whether it will translate to the harsher conditions in England.
Standard Sport asked top agent, Phil Smith, from London's renowned First Artists Corporation, to provide the lowdown on some of the players that could find their way to the Premiership next season. Here is his market guide:
Winston Parks (Costa Rica, Udinese). An English-style centreforward who is a good athlete and quite direct. Looks as though he would fit into the Premiership. Lots of potential at 20. Phil's price tag: £1.5m.
Julius Aghahowa (Nigeria, Shakhtar Donetsk). I am not surprised there is already interest in this striker. He is only 19, although he is possibly a little bit of a luxury and has a lot to learn. But he is very direct and talented. Has impressed me a lot. Phil's price tag: £2m.
Pauleta (Portugal, Bordeaux). The 29-year-old forward had an excellent game against Poland and his hattrick in that 4-0 victory came from first-class finishing. Anyone who keeps Nuno Gomes out of the team has to be some player. Phil's price tag: £5m.
Hasan Sas (Turkey, Galatasaray). This player has got a bit of everything and is quite mobile. He can mix the play up a little and drop behind the strikers and turn provider. He is difficult to deal with and his time at Galatasaray seems to be nearing its inevitable conclusion. Age 25. Scored against Brazil. Phil's price tag: £2m.
Dennis Rommedahl (Denmark, PSV Eindhoven). His skills have really developed in the two years he has been in the national side and he played a key role in PSV's two backto-back league titles in 2000 and 2001. The 23-year-old striker has now come to real prominence. Quite disciplined with good pace, there could be a lot more from him. Phil's price tag: £3m.
Aliou Cisse (Senegal, Montpellier). I know everyone is talking about Pape Bouba Diop but skipper Cisse has also impressed me. He captained Senegal at this year's African Cup of Nations where the West African country reached the final for the first time. The 26-year-old has spent his professional career in France and last season joined Montpellier from Paris St Germain. In 2000 he was a member of the PSG team that reached the French League Cup Final. The Senegalese are not as disciplined as they should be but they have pure raw talent. They have fantastic athleticism, which would make them right for our league. Phil's price tag: £1.5m.
Ronaldinho (Brazil, Paris St Germain). He's really come to the fore at PSG. The 22-year-old midfielder looks like a player for the world stage now. I saw him play in the South America Under-20 championships two years ago in Argentina when he looked promising. This is the first time he's been on the world stage and on that basis people are probably just discovering him. You are talking a lot of money for this guy but I'm sure he will be worth every penny. Phil's price tag: £10m.
DaMarcus Beasley (United States, Chicago Fire). I have seen him play in the States and he's a natural wide player who can also score goals. He can play in the centre but the USA like to play him out wide. He would be a natural for the Premiership. Age 20 and with pace. A real snip. Phil's price tag: £2m.
Clint Mathis (United States, NY/NJ Metro Stars). He's already attracting attention from Bayern Munich and clubs in Italy. After these finals a few English teams are likely to be after him too. He's bright and comes from Texas. The 25-year-old striker has come back from a cruciate ligament injury and is very accomplished. He's a good player and will cost a little more than most in my list. Phil's price tag: £3-4m.
Junichi Inamoto (Japan, Arsenal). I know you will say he's already in the Premiership but Double winners Arsenal are letting him go on a free and he hasn't had a chance at Highbury. After all he only played four times for the Gunners last season. But he's come alive in this tournament and looks a real player. I think there will be plenty of clubs taking a look at him. Phil's price tag: Free - an absolute snip.
Du Wei (China, Shanghai Shenua). The 20-year-old defender is another member of China's squad that played at the FIFA World Youth Championship last year and has graduated quickly to the full national side under Bora Milutinovic. A centre-half of great promise, Du has already been favourably compared with compatriot Fan Zhiyi and playing in a World Cup will hold him in good stead. The same can be said for fellow defender Li Weifeng. Phil's price tag: £2m.
Lee Chun Soo (South Korea, Ulsan Hyundai). At 20, he has a lot more strength than some may think and there is a little bit of arrogance and swagger about him. One of the most exciting young talents in Korean football today. Can play on the wing, in attack or behind the front two and has already attracted the attention of European scouts. Phil's price tag: £1.5m.
Shinji Ono (Japan, Feyenoord). One of the brightest prospects in Japan, this 21-year-old midfielder has fast become a star and is already playing in Europe. Certain to become one of Japan's hottest properties. Phil's price tag: £2.75m.
- More about:
- Arsenal
- David Jones (Footballer)
- Galatasaray SK
- Paris Saint-Germain FC
- Psv Eindhoven
- Senegal
- West Africa


text:
Tweets from @TBHomeTeam/writers
MORE from our HomeTeam writers.
Fri. January 28, 2011 | Derek J. LaRiviere
SPRING HILL — In four trips to regionals under coach Polo Furlong, Springstead had never advanced past the quarterfinals. But his current team was determined to change that.
The Eagles hosted Plant City on Thursday night in a Class 5A region quarterfinal and were able to pull out a 4-3 victory in penalty kicks after working through adversity throughout the match.
"We had the heart to win it tonight," Furlong said. "We are a second-half team, and we pushed through when we had to."
Springstead (11-5-2) allowed the first goal but went to the half tied 1-all with the Raiders (15-6-1) after Kayla Montealegre scored on a game-changing play.
Tara Vasquez was dribbling up-field on Plant City keeper Kiestra Castagno when a collision left the net-minder on the ground and Montealegre was able to put the ball in the net. Castagno was helped off the field and replaced by freshman Emma Mitchell.
Once the second half rolled around, the Eagles really fell behind when Plant City scored twice to go up 3-1.
The flurry of offense upset Springstead keeper Monica Vega so much that she stormed off the field. Sophomore Emma Betters was quick to step in and pick up the slack.
"You get your hopes up that nothing is going to happen, but sometimes you have to deal with 17-year-old minds," Furlong said. "Thankfully, Emma played terrific. We have confidence in her, and she's always been solid for us."
Betters made six saves in the second half and both overtimes while not allowing a goal, and Springstead got back into the game.
With 23 minutes left in regulation, Kimberly Smith laced a shot just under the crossbar and over the outstretched arms of Plant City's Mitchell on a free kick from 35 yards out. The goal cut the lead to 3-2.
As the clock wound to only 8:56, the Eagles tied the score as Ashley Walker scored on a pass from Heleigh McDuff.
Two scoreless overtimes led to penalty kicks. Furlong reinserted a composed Vega into net. In an odd twist of fate, the player who kicked off the scoring, the Raiders' Nidia Castro, missed the final kick to clinch the Springstead win.


text:
Latest Posts
The front of the New York Times Sunday Review was dominated by a graphic of an Escher-type staircase under the headline "Why Women Aren't C.E.O.'s -- According to the women who almost were." If you think you know where the story is going...you're right. It begins and ends with sour grapes from Susan Chira on how sexism foiled Hillary Clinton's presidential hopes. The paper spent the general election contest, from debate coverage to the arts pages, suggesting a vote for anyone other than Hillary Clinton was sexism, while showing no concern over the idea of women voting for Hillary solely because she was a woman.
A Kansas woman who entered a national makeup artists contest has been disqualified from personally redeeming her prize after having been declared its winner. Why? Because, and only because, she posted on Instagram, without comment, a "Trump for President" 2016 graphic on Election Day last year. Despite having all the necessary evidence documenting what happened, the Wichita Eagle's related story headline only conceded that this is something Gypsy Freeman only "says."
Chris Cillizza, an advocacy journalist and politics editor for CNN, is having a very difficult week. Not only did Cillizza struggle to respond to questions asked during an online Reddit AMA [Ask Me Anything] session on Tuesday, July 18, but on the following day, he jumped into a thunderstorm of "Fake News" when he claimed that no media outlet reported anything about a "secret meeting" at which President Donald Trump and his Russian counterpart, Vladimir Putin, engaged in a "sinister" dialogue.
New York Times Houston-based reporter Manny Fernandez continues to champion Democrats and act frightened of the dominant state Republican Party. First, his "Austin Journal" on Friday, "Long-Suffering Texas Democrats Suffer On as Lawmakers Meet," overtly sympathized with those downtrodden Texas Democrats. The next day, he made a slanted, label-heavy return to the subject of the state's "bathroom bill."
Mainstream media bias isn't just against President Trump, but also Israel. On Friday, CNN, NBC, ABC, and CBS published headlines equating three terrorists behind clashes in the West Bank during the day with three Israelis who were stabbed to death the following night in the area.
Christopher Nolan's new movie Dunkirk opened this weekend and is on target to become one of those iconic war movies, much like Saving Private Ryan did. Dunkirk is a gritty and heart-pounding movie that is vividly portrayed on the big screen with classic war themes of duty, trust, honor and the raw tragedy of war.
Friday morning on Fox & Friends, Washington Post Writers Group columnist Ruben Navarrette, Jr. gave President Donald Trump only grudging and partial credit for the steep decline in illegal border crossings from Mexico into the U.S. so far this year.
It's eight months since election day and six since President Trump took office. And the left is still writing stories about how they can't cope with the results. It's like a good chunk of the nation has PTSD or just sore-loser disease. The latest comes to us from the nutters at Bustle. That website pretends to be mainstream, only it's not. It's certifiable alt-left nonsense. The site uses all sorts of hip slang so it pretend be something other than an ad vehicle. Look for terms like "turnt," "BFF," "sassy AF" and more. It's also obsessed with The Bachelor. Oddly, one article was headlined: "How A Grown-Ass Woman Handles The 'Slow Fade' In Dating." Nothing makes a site look like it's not for a grown-ass woman than using that term.
Will Shia LaBeouf's Trump hate save his career? The Transformers star is in big trouble. Again. Could his ardent hate for President Trump help him bounce back? Mel Gibson couldn't get arrested in Hollywood following his oh, so famous public meltdown in 2006.
The Washington Examiner's Paul Bedard had a Friday morning piece that called out The New York Times for "diss-mot[ing]" conservative talk radio host Mark Levin's new book Rediscovering Americanism: And the Tyranny of Progressivism from the number one spot on their secret bestseller list.
The Hollywood Reporter unveils that PBS and its public-broadcasting brethren have written the Federal Communications Commission with a list of complaints. The headline: "PBS Wants the Government to Reexamine Hard Stance on Indecency." That's a funny headline, since we haven't seen a "hard stance on indecency" since the Hays Commission a half century ago. And that wasn't even the government.
With the appointment of Anthony Scaramucci on July 21 as White House Communications Director, this is a good time to take a walk down memory lane with him to exactly two weeks before the November election when he was subjected to a searing attack by always wrong political consultant Bob Shrum on Bloomberg's With All Due Respect. Starting at the 3:50 mark of the following video, Scaramucci commits a Thought Crime by daring to suggest that "Trump Shaming" might be skewing the polls against him. Shrum responds by shaming Scaramucci as "idiotic" for daring to make such a suggestion.
On Friday morning's News One Now, host Roland Martin repeatedly ranted over the 33-year sentence that O.J. Simpson received almost a decade ago, even as the far-left commentator admitted he believes Simpson was indeed guilty of the prior offense of murder that he was acquitted of in 1995. After complaining that the judge in the 2008 armed robbery case had been "shameful" and "despicable," he charged that "white folks can't get over O.J.," leading one guest to provocatively mock whites because they lost a "precious white woman and a precious white man" who were killed by the former NFL star.
Hours after it was announced that Sean Spicer had resigned as White House press secretary, Anthony Scaramucci was announced as the new Director of Communications. In an inaugural press conference, journalists made it all about themselves. ABC's Jon Karl demanded, "Let me ask you a variation of what I asked Sean Spicer on his first day. Is it your commitment to the best of your ability give accurate information and truth from that podium?"
It started Monday as a simple suggestion by former NFL quarterback Michael Vick that free agent Colin Kaepernick might rehabilitate his image with the league by cutting his afro. Now it's erupted into a war of words between ESPN and Fox Sports 1's Jason Whitlock, who called his former employer the "PC, Safe Space Network."


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MATLAB Newsgroup
The following creates a matrix, then breaks it into lines, so that I can send each line as a vector to a function. I dont know if this is the best way, but it seems to work (Generally) However if any of the values in the matrix (array) are greater than 9, i.e double figures, it causes an error. Why? and what is there to fix it.
Thanks Guys
array = [1,2,3;4,5,6;7,8,9]
closeb = (']');
for ii = 1:length(array);
vv = sprintf('%s',num2str(array(ii,:)))
finalstring(ii,:) = strcat(openb,vv, closeb)
% finalnums(ii,:) = str2num(finalstring(ii,:));
% varargin{ii} = finalnums(ii,:);
The problem is the information has to be passed to the other function in the form of vectors.
the function is called allcomb:
allcomb([1 2],[3 4],[5 6])
The vectors above are the rows in my matrix
How do I pass them if I dont always know how big they will be?
Alex wrote:
> The following creates a matrix, then breaks it into lines, so that I can
> send each line as a vector to a function. I dont know if this is the
> best way, ...
Almost certainly _not_ the best way...
> array = [1,2,3;4,5,6;7,8,9]
> The problem is the information has to be passed to the other function in
> the form of vectors.
> the function is called allcomb:
> allcomb([1 2],[3 4],[5 6])
> The vectors above are the rows in my matrix
Well, [1 2], etc., are _NOT_ the rows of the matrix array you gave
above...those are vectors of length 3, not 2.
What would be wrong w/
a) Passing the rows as array(1,:), array(2,:), etc., ...,
or, since that is still really ugly for an arbitrary size array,
b) Write the function to accept an array and have it inspect the size of
the array and do whatever it is that it does dynamically based on that?
Let's go back a step instead of working on this kludge and tell us what
you're trying to accomplish and get input from cs-sm on the way to
accomplish that goal instead.
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text:
NHS Grampian
Also in Dr Gray's Hospital - Elgin:
This information is designed to help you prepare for a visit to our hospital. You may also find it useful to refer to the other sections such as General Information. If you have any further questions please do not hesitate to ask a member of staff.
Visiting times vary from ward to ward. The visiting times are usually displayed outside each ward. If they are not please ask the ward staff or receptionist. Generally relatives and friends are encouraged to visit between the hours of 2.30pm to 4.30pm and 6.30pm to 8.00pm.
You can phone the ward before planning your visit to confirm what the visiting times are, by calling the NHS Grampian switchboard on 0345 456 6000 and asking to be put through to the ward.
Remember that although visiting times are quite extensive, it is not intended that visitors remain for the entire visiting period particularly for those who may be quite ill. In most instances this is not in the best interests of patients. It is often helpful for family and friends to plan their visits in such a way that the patient has the opportunity to have regular visitors, but for short periods only. Your co-operation will be appreciated by both patients and staff
Only 2 visitors are allowed at your bedside at any one time. Children may visit you at the discretion of the nurse in charge. As you will appreciate some restrictions on visiting are essential to ensure that ward staff are able to carry out their duties. If circumstances make it very difficult for friends or relatives to visit during normal hours, please approach the nurse in charge who will consider individual circumstances sympathetically.
You are requested to :
We appreciate that you will be anxious to learn of your relatives or friends progress by telephone. However, it would save considerable staff time if calls to the ward telephone were limited to immediate members of the family. If possible, one person only should call on behalf of the family. Please note that due to confidentiality, staff can only give out limited information over the phone.
This does not apply to telephoning patients via Patientline® where this is available.
The use of mobile phones is not permitted in the hospital. The signals can affect vital medical equipment. Please switch off your mobile phone before you enter the hospital.
Please try to keep noise levels down as noise disturbs people who are unwell.
Everyone has a role to play in helping prevent the spread of Healthcare Associated Infection (HAI). NHS staff are doing a great deal, but we can't overcome these problems without the involvement of the public.How you can help - as a visitor
If you have any further concerns please feel free to contact the Infection Control Team on 01224 550998.
When in hospital, relatives and friends often bring in a patient's favourite food from home as a treat. Any food brought in should be branded goods, in sealed packets with a sell by date. It should not require re-heating. Please speak to the nurse in charge before giving a patient food brought from outside the hospital.
Please note that the hospital cannot accept responsibility for foods not prepared by us.
Small flower arrangements
Plants in containers
Tobacco products
Large bulky products
Large amounts of food
Food that needs re-heating


text:
Don't know if its thread worthy but I didn't see a game 2 thread started yet. Looks like JRs adjustments didn't involve taking the night off from partying before a game.The 40/40 Club @The4040
Cam Newton, JR Smith, CC Sabathia, CJ Watson, Andre Blatche and Joe Johnson in the building! The lineup is serious tonight NY!
Could be a ploy to put that thought in the Pacers heads too but who knows. Just glad the FO didn't go out and get this guy during his FA. Some ppl just don't change


text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The capacity of the brain to generate new adult neurons is a recent discovery that challenges the old theory of an immutable adult brain. A new and fascinating field of research now focuses on this regenerative process. The two brain systems that constantly produce new adult neurons, known as the adult neurogenic systems, are the dentate gyrus (DG) of the hippocampus and the lateral ventricules/olfactory bulb system. Both systems are involved in memory and learning processes. Different drugs of abuse, such as cocaine and MDMA, have been shown to produce cellular and molecular changes that affect adult neurogenesis. This review summarizes the effects that these drugs have on the adult neurogenic systems. The functional relevance of adult neurogenesis is obscured by the functions of the systems that integrate adult neurons. Therefore, we explore the effects that cocaine and MDMA produce not only on adult neurogenesis, but also on the DG and olfactory bulbs. Finally, we discuss the possible role of new adult neurons in cocaine- and MDMA-induced impairments. We conclude that, although harmful drug effects are produced at multiple physiological and anatomical levels, the specific consequences of reduced hippocampus neurogenesis are unclear and require further exploration.
The adult mammalian brain has two main regions capable of constantly producing new cells: the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles [
The discovery of adult neurogenesis in the second half of the 20th century prompted an explosion of research focused on this process. However, the full relevance of the functional significance of adult neurogenesis is still unclear. It is known that adult neurogenesis ocurrs in all mammalian species, including humans [
Recently, different studies have suggested that the production of new neurons in the adult brain is also implicated in functions conferred to the OB and DG [
Given that adult neurogenesis may be implicated in some brain functions, it is of interest to analyze the factors that may modify neurogenesis. Many studies show that neurogenesis can be modulated by positive and negative factors. For example, exposure to an enriched environment and physical activity increases neurogenesis of granular cells in the DG of adult mice [
Drugs of abuse, such as nicotine, ethanol, cocaine and amphetamine derivates, have also recently been considered as negative factors that affect adult neurogenesis, mainly in the hippocampus [
Cocaine is one of the most widely consumed illegal drugs in developing countries and is associated with several health problems [
In both human users and experimental models some of the cognitive functions linked to the DG are affected by cocaine treatments, such as working and recognition memory [
On the other hand, in the adult brain, the participation of new hippocampal neurons in some memory processes is firmly established [
In relation to the OB, there are few reports of how drugs of abuse can affect this neural system, but it is known that olfactory perception is disrupted in cocaine addicts [
In addition, cocaine disrupts neurogenesis in the SVZ-OB system (summarized in
MDMA has become a highly popular recreational drug in the last decades and is associated with a range of acute and long-term hazardous effects [
In relation to the DG and other hippocampus subfields,
Studies performed in animal models have shown that MDMA administration also impairs adult neurogenesis (summarized in
Although MDMA-exposure is related mainly to modifications in serotonin neurotransmitter levels, it also can alter dopamine levels. In this context, the OB is of great relevance, as olfactory cells constitute the major dopaminergic system of the forebrain [
Besides the neurotoxicity induced by MDMA-administration, this psycho-stimulant alters spontaneous behavior related to psychomotor activity. Thirty minutes after treatment with MDMA, locomotion increases, as does olfactory exploration, which includes sniffing and head movements. However, treatment decreases stimulus-induced behaviors such as jumping, retrieval of food and scratching [
In summary, drugs affect neurogenic regions of the adult brain, with the DG being the best documented region in this respect. Cocaine-administration is related with deficits in proliferation of progenitors/precursor cells, whereas MDMA disrupts the survival and maturation of new cell populations. However, other alterations of new adult generated neurons may also be affected. Drugs that induce detrimental effects in adult neurogenesis are dose-dependent, and these effects are reverted after a withdrawal period. Besides adult neurogenesis modifications, exposure to cocaine or MDMA produces a series of alterations in the DG and OB that involve receptors, cellular and synaptic modifications.
Since the Nottebohm group's studies in canaries [
Drugs of abuse are systemically detrimental compounds, but in this review we explore only the neural alterations produced in the functional systems where new neurons are integrated, using MDMA and cocaine as models.
Cocaine and MDMA alter DG synaptic activity. Both acute and chronic administration of cocaine influences DG activity. The amplitude of the LTP induced is decreased in slices from animals that receive 15 mg/kg i.p. of cocaine for two days [
In this respect, there are few studies that link adult neurogenesis with drug-induced cognitive impairments. One of the most interesting reports to have been published indicates that adult neurogenesis is linked with drug-taking or drug-seeking behaviors [
Other types of memory that do not have a high emotional association are more difficult to link with adult neurogenesis. It has been described that working memory is impaired by high doses of cocaine self-administration (14 days) in a water maze task (four days after drug treatment) [
Neurogenic systems have the capacity to constantly regenerate by creating new neurons during adulthood through a dynamic and highly regulated process known as adult neurogenesis. A wide range of extrinsic and intrinsic factors are reported to reduce adult neurogenesis, and recreational drug use is among them. The mechanisms that have been proposed to interfere with adult neurogenesis are usually classified in two major groups: neurotransmission modifications and increased pro-inflammatory mediators. We have not focused on the mechanism of action of cocaine and MDMA with respect to adult neurogenesis. We have documented how these drugs produce different molecular and cellular changes in neurogenic systems. We believe that that the complexity of these changes, together with a lack of knowledge about neurogenesis system function, make it difficult to evaluate the functional role that new cells play in drug-induced impairments. Current theories about adult neurogenesis function link adult neurogenesis impairment with the impairment of both stable drug memories and working memories that occurs through an undermining of the efficiency of neurogenic systems. Further investigation of the function of adult neurogenic systems is the key to understanding this process.
The function of adult neurogenesis is an issue of great interest, but its full relevance is yet to be elucidated. Before reaching that point, many neural mechanisms need to be understood. Some results indicate that adult neurogenesis is essential in certain situations with increased memory demands [
Effects induced by cocaine and MDMA in adult neurogenesis.
|Repeated administration of cocaine induces a decrease in the proliferation rate of DG progenitor cells
|The acute administration of cocaine does not produce changes in the proliferation rate
|Impairment of cellular division caused by cocaine consume is normalized after a period of withdrawal
|Chronic cocaine administration may induce an increase of the proliferative rate within the DG after a short-term period of abstinence (2-4 days)
|Chronic cocaine treatment does not affect the survival of new cells
|Effects of cocaine on cell maturation are controversial
|Analysis of Ki67 expression revealed a decrease in proliferation of rat SVZ after cocaine-treatment
|The number of new cells incorporated into the OB a week after BrdU administration was reduced after cocaine-treatment
|MDMA reduces the proliferation rate under some administration patterns in some cases, but not in others
|The proliferative rate in the DG is reduced after intensive MDMA treatment
|Binge administration of MDMA does not reduce the rate of proliferation, but affects cell survival of new cells in the DG
Both authors, VHR and VCG, contributed equally to write the manuscript.
The authors have no conflict of interest regarding this manuscript.
We are grateful to L. Chen and J. Aguayo from the Brain Tumor Stem Cell Laboratory, at Johns Hopkins University, and B. Normanly, at the Príncipe Felipe Research Center, for their English proofreading and helpful comments for improving our manuscript.
conditioned place preference
dentate gyrus
long term depression
long term potential
recpetors of NMDA
olfactory bulb
polysialylated form of the neural cell adhesion molecule
rostral migratory stream
subventricular zone


text:
RFF Archive > The Amazing Race 22
TAR 22 Scheduling-Airing Times-Delays
<< < (17/17)
Is there any delay today? I am finishing an essay and *may* stay up to see the episode, depending on the time it airs. Thanks a lot.
I think it's on time, there is no Tweet from CBS or The Amazing about having a delay and 60 minutes is on.
[0] Message Index
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text:
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-------------------------------------------------------------------------- © 2011 - 2016 Bali Discovery Tours, All rights reserved. This hotel originated from http://www.balidiscovery.com/ Find it online at http://www.balidiscovery.com/hotels/hotel.asp?Id=523 --------------------------------------------------------------------------
The Shaba is a luxurious mansion found in Jimbaran, in spectacular southern Bali. This three suite tropical mansion can offer its guests the utmost in relaxed comfort including full butler service, with no detail overlooked. Its unique architecture and stunning interior design make it a perfect "get away".
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text:
Creative Millwork's Mark Estock Passes Away
Window & Door
November 12, 2013
November 12, 2013
Mark Estock, president and CEO of Creative Millwork of Ohio Inc., passed away November 5 at the age of 53 after a three-year battle with cancer. Estock joined Creative Millwork 25 years ago to partner with his father, Joe Estock, to develop new grille technologies and product innovations. He was the president and CEO for the past seven years.
Company officials express that "Mark Estock's commitment to our Creative Millwork Family and his many contributions to our community and schools cannot be measured."


text:
"Julie & Julia": Review Roundup
After all the hype, director Nora Ephron's dual-biopic of cooking legend Julia Child (Meryl Streep) and foodie blogger Julie Powell (Amy Adams) is finally hitting theaters. We will try to eschew food metaphors here (well, except for the "chew" part) and instead mention that while Streep and Adams both had juicy roles in "Doubt," their last film together, Adams — as critics are quick to point out — clearly drew the short end of the stick in this cinematic face-off. (She fares better than the the heroines' male counterparts, however, but whatevs! After decades of women being typecast as patient nurturers, turnabout is fair play). A sampling of the reviews.
- "The joys of the Julia parts are cumulative, and addictive. The Julie parts keep forcing us to go cold turkey." [Joe Morgenstern, WSJ]
- "The image of Streep's china-plate face topped with Child's curled red hair is automatically amusing. But she sings in Child's congested falsetto with an uncanny blend of phlegm and melody. It's Child in the key of Streep. ("What could this mean?'' she intones, pouring over an entry in a Larousse dictionary.) Ephron expresses a loud vote of confidence in her star's interpretation when she sits the Powells down on the sofa to laugh at Dan Aykroyd's "Saturday Night Live'' version of Child. The director is showing us the difference between inspired sketch comedy and actorly soul." [Wesley Morris, Boston Globe]


text:
As Thierry, an activist in the independent SUD trade union, told Socialist
Worker on Saturday, the strength of the campaign comes from its link with the
movement against privatisation and other attacks — "If the no campaign is
victorious it will put the idea in people's heads that the neo-liberal machine
can be stopped."...
Nothing could sum up, better than this, the other-worldliness of the lumpen intelligentsia that makes up the new left. A 'NON' vote may put the idea in people's heads that the neo-liberal machine can be stopped, but in reality, a rejection of a common European stand in defence of history's most successful and progressive social model (the one found throughout most of the EU currently) may prove to be one of the most serious mistakes.
As exhaustively demonstrated by Phil Edwards excellent round-up.


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… my inner guru is named Dave!
Who'd a thought it?
Today was a mini-workshop on Kundalini yoga and because David was leading the workshop and because David loves to chant, it was a heavy on the singing.
I still haven't figured out how to work my way around the whole chanting thing. I understand that, for a lot of people, chanting is a calming, soothing way to clear out all the internal chatter and center one's energy. Really not so for me; at least, not yet. I'm trying to keep an open mind about the whole thing.
Anyway, I've whined about chanting here often enough, so I'm not going to do it today. What I wanted to tell you all was that I learned today that my inner guru is named Dave.
I was surprised to learn this.
David taught us this chant this morning:
Om guru, om guru, om gurudev
Jaya guru, jaya guru, jaya gurudev.
That last bit – gurudev – is pronounced, at least as we were taught it this morning, like "guru Dave."
You know what? I would never have guessed that my inner guru was named Dave. I'd have thought her more of a Grace or a Celeste or, I don't know – Chili?


text: On Jun 25, 2008, at 5:42 PM, Jeremy Mann wrote: > First, Maui has pretty much solved our problems with submitting 100k+ > jobs. It was simply overloading the stock PBS scheduler. But now I'm > coming into a (maybe) configuration problem. > > I have one user who submits 100k+ jobs. This works fine for the first > couple thousand jobs, which line up in the queue and begin to execute. > However after a certain time, the queue is only visibily filled > with 15 > jobs. There are still thousands of jobs hidden. I can see this if I > run > qstat multiple times in a row, the queue is repopulated with 15 > more jobs. > The jobs only run for about 45 seconds so I'm thinking Maui isn't > picking > up on this? I had a similar situation with a user submitting 7,000 jobs at a time. Like you point out maui can't seem to keep up with scheduling all of them. After posting to the list it was suggested that I create a routing queue in torque: create queue physics set queue physics queue_type = Route set queue physics acl_group_enable = True set queue physics route_destinations = pompeii set queue physics enabled = True set queue physics started = True Then for the destination queue pompeii I put in the following rule: set queue pompeii max_queuable = 50 This setup is working well. Torque manages to keep 50 jobs in the pompeii execution queue at all times. Maui is happy since it doesn't have to go through thousands of jobs each iteration, which it couldn't run anyhow due to lack of resources. (I wish we had thousands ;-)). > > My second question is probably more important. We run two PBS > environments > on all of our clusters. One is our 'default' high priority queue > and the > second is the 'default' low priority queue. The low priority queue > is for > jobs that run at nice 19 or 20. So we load up the low priority > queue with > niced jobs and don't care how long they take to finish. This leaves > the > high priority queue to process our own grid and MPI jobs. > > This has worked fine for awhile, but now I have a user who wants to > run a > few hundred thousand jobs in our low priority queue (see paragraph > 1 and > 2). The stock pbs_sched was simply getting overloaded and would crash. > This is when I set up a test cluster using PBS/Maui and we haven't > had a > problem (other than the 15 queue limit I spoke of before). > > Yesterday, I set up a second Maui to schedule the low priority > queue. I > could submit jobs, check job status, however the jobs would never run. > This is when I started checking the Maui logs and found checksum > errors. > This is when I discovered the problem. The $PATH environment picks > up the > normally installed Maui and uses its binaries to perform its > functions. > Turns out the checksum error is when the normally installed Maui > tries to > process and query the second low priority queue. I can get around > this by > using the second installed Maui's binaries to query the low priority > queue. If there is a way to disable this at compilation time, I > think my > problem will go away. > > I look forward to any comments or questions! > As for having two separate instances of torque/maui I'm not sure why you would want to do this? Are they load balanced or something? One instance of torque/maui should be able to handle everything you need plus you won't have this confusion of keeping track of multiple binaries/installations. -Steve


text:
nadia abduljabbar
Songs - Poem by nadia abduljabbar
"I guess the breeze your
Soft steps,
And Whisper your yell",
So explained father
To me, while putting
Me on his lap,
One of Umm Kalthoom's
Songs, when I was
Only five.
How could he foresee
That I am going to
Be a poet,
I never knew.
I was brought up
To listen to Nagat,
Faizah and the rest of
That great generation
Of singers,
I loved old Iraqi and
Lebanese songs,
Few Syrian and
Northern African Songs.
I was and still fond of only three
Songs from Arabia;
One from the south:
I Follow my Heart:
"Ana Ba'atba' Galbi",
And " We differed who loves the other one More":
" Ekhtalafna".
Now days, I am
Open to a new
Experience of
Listening to many of
My Home town songs,
And I like it,
Especially because
Some of them remind me
Of mother and aunt.
We never lose our
Identity however
Far we go.
I still love old English songs:
Such as "Why is my Heart so Light" and
"Those Were the Days my Friend;
They are attached to my adolescence.
Now most my time is
For Qur'an,
Yet I still love songs,
But I try as much as I can
To minimize things that
Attach me to dreams
Otherwise, I will lose myself.
8 April,2013
Comments about Songs by nadia abduljabbar
Sekharan Pookkat (6/5/2013 10:44:00 AM)
Songs from Arabia brought the dry wind
Along with the smell of yam- good work (Report) Reply
Read this poem in other languages
This poem has not been translated into any other language yet.
I would like to translate this poem »
nadia abduljabbar's Other Poems
Famous Poems
Phenomenal Woman
Maya Angelou
Still I Rise
Maya Angelou
The Road Not Taken
Robert Frost
If You Forget Me
Pablo Neruda
Langston Hughes
Annabel Lee
Edgar Allan Poe
Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


text:
Set 1: Annotation/note-taking
This set is about types of activity they are realised traditionally by some form of pen/pencil and asome physical surface to write on. The iPad affords or lends itself to the replacement of these practices - and, crucially, does it well. What I've learnt over the last few months about iPads is that lots of things that can be achieved clunkily or messily with other devices can be achieved with ease and comfort. As a result, people will do these things. For the types of apps in the below mindmap this is most definitely true.
Represented below is an embedded mindmap which groups types of activity and then identifies individual iPad apps which fit within this category. Find the best fit for your context by exploring them. With the many 1000s of apps out there the list can only be introductory. However, all those listed have been tested and some recommended by colleagues.
Write/record notes
This is a crucial area because this process is often the gateway application of iPads into this type of devices and its use in any context. As this process applies to any meeting, any lecture and any class this is a core function. The key strength is its multi-purpose use as any self-respecting note-taking app will perform a number of functions which previously would require a number of devices or objects.
Firstly, the usability of typing on an iPad is surprisingly good. I have played with an external keyboard but I prefer the onscreen keyboard display (just remember to turn the sound off to avoid annoying others). It's really no different than a laptop in this regard and the eye strain is less. Most apps allow for finger/stylus drawing and the easy creation of simply shapes. If you stopped there it would still be worthwhile using an iPads for these functions as the integration to cloud computing services (described below) save time.
However the additional functions are the real selling point. With an iPad I can take photos. My app of choice is notability. With this app I can take a photo of a detailed, wordy slide to save me frantically typing it. In addition, I can record the audio. I no longer need a dictatphone for this. Of course, everyone in the room need to agree for this but to have this available easily is great. From the iPad 3 onwards there is a record button on the keyboard. If you have an iPad 2 you'll find record options within most of the note-taking apps. Then there is this thing called the internet. Embedding screenshot, adding hyperlinks and simply accessing the internet during a meeting is of real value.
In the below video a UK university student reflect on her use of notability for note-taking:
How I use my iPad - Emma Vaccari from Manchester Medical School on Vimeo.
Of the apps listed in the relevant mindmap section above my favourite is notability. I often export in pdf format by the old school email route but increasing I am taking notes and then simply storing then in the app for future reference. This shows that the iPads is becoming embedded into my practice. I also use Pages because this is the only one I've found that allowing for exporting into word for continued editing. However, the price of this annoys me so it makes scaling onto numerous devices a costly business. Of the free one, paperdesk is a good starting point as well as the native notes app. Also, I could see a scenario where I switch to evernote which is also free. Evernote is a fantastic , established note-taking, archiving service and the iPad app they have created is a good one. The synchronisation with your evernote account means that if you are an existing evernote user there is no need to email or use a cloud computing service for extraction.
It's worth mentioning a couple of write to text apps - Smart Writing Tool and WritePad. However, it would be wrong to comment further as I have not played with them (the costs is pretty high). On this subject, the fact that most note-taking apps cater for stylus or finger writing means that the perceived threat the handwriting need not be the case. You could even perform handwriting classes using the iPads. Although I can type faster than I can write these days I try to use my stylus every so often just to keep this core skill up to speed.
As note-taking is of value in workplace as well as classroom settings this type of activity is easy to practice in a risk free but authentic context. You can simply ask a colleague to try a note-taking app in a meeting. It's easy to pick-up and demonstrate and the benefits will speak for themselves. Pick a context where the ability to take photos, go online or draw shapes would be useful.
Next time - Annotation.
The structure of the forthcoming blog posts is listed below:
Set 1: Annotation/note-taking
- Write-record notes
- Annotation
- Drawing
- File Management
- Digital Storytelling - Cartoon/Comic creation
- Digital Storytelling - Flipbook animation
- Digital Storytelling - Story from research
- Drawing
- iBook creation and reading
- Image Creation
- Poster/Collage Creation
- Location-based
- Audio - Record/edit/share
- Digital Storytelling - Narrated slideshow
- Digital Storytelling - Narrated Cartoon
- Screencasting
- Narrate over drawing/image/text
- Video - Stop-motion
- Video - Analysis
- Video - Create/edit
- Fun classroom management
- Computer Connection
- Projecting an iPad
- Teacher Organisation
- File Management
- MS Office/Windows Connection
- Audio - Record/edit/share
- Blogging
- Mindmapping
- Noticeboards
- Narrate over drawing/image/text
- Quick brainstorming
- Revision - Flashcards
- Screencasting
- Social Networking
- Bookmarking
- Research - Browsing
- RSS - Aggregation
- Research - Tailored Browsing
- Audio - Record/edit/share
- iBook creation and reading
- Mindmapping
- Narrate over drawing/image/text
- Poster Creation
- Presentation
- Printing
- Screencasting
- Video - Create/edit
- Revision - Flashcards
- Video - Analysis
- Class collaboration - viewing lesson on each device
- Computer connection
- Q&A - Real-time
- Webinars


text:
Strategy Games
The Hollow Village
Explore a cursed village and find out what is going on there.
Color Bounce
Click and drag the colored paddles to match the color of the ball.
Monopoly Online
Play the classic real estate tycoon game online!
Arcade Games
Super Spin IO
Select a spinner and compete against other players. Collect gems to increase your spin rate. Press the mouse button to m...
Doodle Jump Online
Use the arrow keys or mouse to jump up the platforms. Collect power-ups to boost your height. Avoid enemies and obstacle...
The Floor is Lava
Hop up to escape the lava! You can only jump to the left or right. One wrong move will end your escape!
Puzzles Games
Classic Mahjong Connect
Match tiles to remove them. Clear the entire board to move on to the next level.
Tiki Solitaire
Play a relaxing game of solitaire in a Tiki setting.
Hotel Solitaire
Welcome to Hotel Solitaire. Take the elevator to reach one of its 20 floors. On each floor you will find 5 rooms, each w...


text:
Job Summary
- Salary: Undisclosed
- Work Type: Permanent / Full Time
- Min. Education Level: 'N' / 'O' Levels
- Field of Study: Not Applicable
- Skills: Customer service, Sales
Job Descriptions
Interested in doing something that is beyond your basic salary and earn more extra cash?$$$$$
Passion in Clothing wear industries and intend to move a step higher towards Luxury Industries?
Here's a chance for you to come into the Sales/Retail industry for a fun and fruitful experience!!
- Pre-sales consultation of product
- Promote and upsell
- Serve customer and assist their needs
- Assist and provide customer with latest promotion
- Assist with Fitting room duties
- No Experience Required as training will be provided
- Minimal Experience in Retail sales or customer service is a plus
- Basic Knowledge of sales is a plus
- Able to commit retail hour
- Location: Orchard
- Singaporean/Singapore PR Only
Apply now and bring yourself up to another level!!!
Reg: R1328975


text:
- 1 cup quick-cooking oats
- 1/4 cup sliced almonds
- 10 dried apricots, minced
- 10 pitted prunes, minced
- 3 large dried Calimyrna figs, stems removed and minced
- 1 1/4 cups unsweetened apple juice
- 1/2 cup all-purpose flour
- 3 tablespoons unsalted butter, softened
- 1 teaspoon cinnamon
- 1/2 teaspoon baking soda
- Pinch of salt
- 3 tablespoons unsulphured molasses
- 1 teaspoon pure vanilla extract
- Vegetable oil cooking spray
Preheat the oven to 400°. Toast the oats and almonds on separate baking sheets in the oven for about 7 minutes, or until golden. Let cool.
In an ovenproof saucepan, bring the apricots, prunes, figs and apple juice to a boil over high heat. Reduce the heat to low and shimmer for 5 minutes. Transfer the saucepan to the oven and bake for about 30 minutes, stirring occasionally, until most of the liquid has evaporated. Let cool. Lower the oven temperature to 350°.
In a bowl, combine the flour with the butter, cinnamon, baking soda and salt. Add the oats and mix until the butter is distributed. Add the molasses and vanilla and mix until a dough forms. Shape the dough into a disk, cover with plastic and refrigerate until chilled, or for up to 2 days.
Lightly coat a 10-inch springform pan with cooking spray and line with parchment paper. Press the oatmeal dough in the bottom of the pan to a 1/4-inch thickness. Bake for about 15 minutes, or until lightly browned. Let cool slightly, then remove the sides of the pan. Invert the crust onto a plate and peel off the parchment.
Cut the oatmeal crust into 12 wedges. spoon the fruit compote into a bowl, sprinkle with the almonds and serve with the oatmeal wedges.