text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. However, the complexity of death receptor signalling has increased substantially during recent years. Beyond activation of the apoptotic cascade, involvement in a variety of cellular processes including inflammation, proliferation and immune response was recognised. Mechanistically, these findings raised the question how multipurpose receptors can ensure selective activation of a particular pathway. A growing body of evidence points to an elegant spatiotemporal regulation of composition and assembly of the receptor-associated signalling complex. Upon ligand binding, receptor recruitment in specialized membrane compartments, formation of receptor-ligand clusters and internalisation processes constitute key regulatory elements. In this review, we will summarise the current concepts of death receptor trafficking and its implications on receptor-associated signalling events.
Molecules of the tumor necrosis factor (TNF) superfamily (TNFSF) and TNF-receptor superfamily (TNFRSF) are highly conserved and found in almost all mammalian cells. Evolutionarily, these proteins evolved with or soon after the divergence of bony fish and tetrapods, approximately 350–450 million years ago [
In this review, we will first briefly recapitulate general aspects and structural characteristics of DR signalling, before addressing pathways of specific receptor-ligand systems and their implications in (patho-) physiology in detail. Based thereon, we will discuss implications of membrane trafficking, especially receptor internalisation, on DR-associated signalling pathways.
Structurally, TNFSF members are type-II transmembrane proteins, with a C-terminal TNF homology domain (THD). The latter is composed of 10 β-strands, folded to form a compact jellyroll-like topology [
The cognate receptors are predominantly type-I transmembrane proteins, with only a few classified as type-III transmembrane proteins [
Structurally, the DD is a up-and-down antiparallel β-sheet fold with "Greek key" topology [
Among the TNFRSF, the signalling outcome may fundamentally differ between DR and non-DRs and is furthermore complicated by cross-talk with other, partly overlapping signalling pathways and membrane trafficking events that regulate or modulate assembly and/or association of the receptor signalling complex (RSC). Despite the suggestive designation "death receptor", DR signalling is far more than cell death induction and also comprises non-apoptotic signalling pathways.
Binding of a trimeric ligand to the corresponding trimeric receptor triggers recruitment of intracellular adapter proteins [
Both adaptor proteins in turn recruit distinct signalling complexes: TRADD recruits RIP1 (receptor-interacting serine/threonine-protein kinase 1) via the DD. Subsequently, RIP1 recruits TRAF2 (TNF-receptor associated factor 2), cIAP1 (cellular inhibitor of apoptosis protein 1) and cIAP2, triggering a downstream phosphorylation cascade finally culminating in activation of the inflammatory and survival pathways NFκB, JNK and p38 [
Non-apoptotic, TRADD-mediated DR-signalling is regulated by ubiquitination at various steps and is also a good example to demonstrate the impact of the specific type of the ubiquitin modification. Generally, monoubiquitination of proteins is believed to target them for endocytosis, whereas addition of K11- or K48-linked polyubiquitin chains is associated with proteasomal degradation. In contrast, K63-linked or linear polyubiquitin chains have roles in signal transduction and DNA repair [
Efficient activation of NFκB, JNK and p38 requires assembly of K63-linked polyubiquitin chains on RIP1, serving as docking sites for TAK1 (transforming growth factor-β activated kinase-1), TAB2 (TAK1 binding protein 2) and the regulatory subunit of the IκB kinase complex NEMO (NFκB essential modulator) [
In contrast to TRADD, the alternative adapter protein FADD possesses beside the DD an additional DED, a structurally similar protein-protein interaction motif. The DD of FADD allows direct recruitment to the DD of DRs, but also association with TRADD and therefore recruitment to initially TRADD binding receptors. In addition, the DED mediates interaction with caspase-8 and caspase-10 by homotypic interaction with the DED in the prodomain of these molecules [
In context of caspase-dependent cell death induction, signalling pathways emanating from TRADD or FADD binding DRs run together at the point of FADD oligomerisation that triggers caspase-8 and caspase-10 activation through an induced proximity change of conformation. The complex of a DR with FADD and caspase-8 or caspase-10 constitutes the death-inducing signalling complex (DISC). FADD and caspase-8 or caspase-10 can either be directly associated with DRs (FADD binding DRs), or through DD-mediated recruitment of the complex to TRADD or RIP1. Therefore, complexes containing FADD and caspase-8 or caspase-10, regardless whether directly assembled at the DD of DRs or recruited via TRADD or RIP1, can all be considered as DISCs.
Understandably, caspase activation is a tightly regulated process to avoid undesired cellular damage. At the DR level, DISC-mediated caspase activation is regulated by the long isoform of the cellular FLICE-like inhibitory protein (cFLIP-Long or cFLIPL). This molecule exhibits considerable sequence homology with caspase-8 and caspase-10, but lacks a crucial cysteine residue in the catalytic center and is enzymatically inactive. cFLIPL prevents caspase-8 and caspase-10 activation by DED-mediated binding to FADD, thereby occupying the binding sites for caspases [
Ignition of the apoptotic cascade through caspase activation can be subdivided in an initiator phase, characterized by unlocking the initiator (or apical) caspase-8 and caspase-10. The execution phase of the apoptotic programme starts with proteolytic cleavage of the corresponding effector caspases (caspase-3, caspase-6, and caspase-7), which in turn again cleave essential cellular substrates and thereby execute the apoptotic cell death programme [
Mechanistically, the mode of transition from initiator to execution phase allows identification of two distinct cell types. In so-called type-I cells, activation of initiator caspases is sufficient for robust triggering of the death machinery and yields sufficient amounts of active effector caspases. In sharp contrast, activation of initiator caspases is insufficient in type-II cells. Insights in the biochemical basis came from recent studies, tracing back failure of robust caspase activation in type-II cells to low cell surface DR expression [
Therefore, these cells require a mitochondrial amplification loop to efficiently activate effector caspases. In this scenario, caspase-8-mediated cleavage of the BH3-only protein Bid (BH3-interacting domain death agonist) generates truncated Bid (tBid), which translocates to the outer mitochondrial membrane (OMM) and allosterically activates Bak (Bcl-2 homologous antagonist/killer). Subsequent oligomerisation of Bak and Bax (Bcl-2 associated X-protein) forms pores in the OMM and allows escape of pro-apoptotic proteins such as cytochrome c, SMAC/DIABLO (second mitochondria-derived activator of caspase/direct IAP binding protein with low pI) and HtrA2/Omi into the cytoplasm [
In this section, we address the specific characteristics of individual receptor-ligand systems of the DR group. Although membrane trafficking events have been recognised as key regulatory processes in DR signalling, not all members of the DR subgroup have been thoroughly characterised in this respect. In fact, data on the implications of membrane trafficking on death receptor signalling exist for TNFR1, TRAIL-R1, TRAIL-R2, Fas and partly for DR3. Therefore, we will focus on these members of the TNFRSF and leave other DRs such as EDAR and DR6 aside.
The TNF gene is located on chromosome 6p21.3. TNF is primarily produced as homotrimeric type-II transmembrane protein [
The gene for TNFR1 is located on chromosome 12p13.31, encoding a protein of 425 aa [
A profound coverage of the pleiotropic TNF/TNFR1 system in health and disease would require a book rather than a review and is therefore beyond the scope. In brief, a role for TNF has been suggested in autoimmune diseases, such as psoriasis, inflammatory bowel disease, arthritis, systemic sclerosis, diabetes mellitus and multiple sclerosis [
In addition to the involvement of TNF/TNF1 in autoimmune disease and malignancy, mouse models highlighted the role of this receptor ligand-system in the immune system. In particular, TNF or TNFR1 deficiency rendered these mice highly susceptible to the intracellular pathogen
During recent years, information on TNFR1 signalling virtually exploded and painted a complicated picture of signalling events associated with TNFR1. Especially, new regulatory mechanisms such as ubiquitination of signalling components attracted considerable attention [
Although TNFR1 can trigger the apoptotic cascade, under physiological conditions TNFR1 primarily exerts pro-inflammatory effects. Within minutes after ligand binding, RIP1, TRAF2 (TNF receptor-associated factor 2) and cIAP1/2 (inhibitor of apoptosis protein 1/2) are recruited to the receptor and form a complex often referred to as complex I [
Receptor internalisation is a crucial event in TNFR1 signalling and significantly influences the cellular response of this multipurpose receptor. Upon ligand binding, TNFR1 undergoes clathrin-dependent internalisation in various cell types. The first hints for a regulatory role of TNFR1 internalisation arose from studies with human endothelial cells, demonstrating a decrease of TNF-induced expression of NFκB target genes after blockade of receptor internalisation [
Indeed, propagation of the death signal from TNFR1-containing vesicles has been resolved at the molecular level. TNFR1 internalisation was essential for assembly of the DISC [
Internalisation of TNFR1 does not only trigger pro-apoptotic signals, but also terminates NFκB activation that occurred at plasma membrane level. Two E3 ubiquitin ligases, CARP1 (cell division cycle and apoptosis regulator protein 1) and CARP2 colocalize with TNFR1 in the endosomal compartment and mediate RIP1 ubiquitination, targeting the molecule for proteasomal degradation [
Another membrane trafficking event involved in regulation of TNFR1 signalling preceeds receptor internalization. Upon ligand binding, TNFR1 translocation into membrane lipid rafts was identified as a prerequisite for association with TRADD, TRAF2 and RIP1. Additionally, ubiquitination of RIP1, a crucial event for TNFR1-mediated NFκB activation, was also reported to be dependent on lipid raft association of TNFR1 [
Taken together, TNFR1 internalisation actively shuts down pro-inflammatory and pro-survival NFκB signalling emanating from the plasma membrane, allows DISC assembly with subsequent caspase activation and furthermore activates ASMase potentially via a caspase-dependent and a caspase-independent mechanism. Therefore, trafficking of TNFR1 from the plasma membrane into TNFR1-receptosomes determines the signalling outcome of this pleiotropic receptor and is decisive for apoptotic or non-apoptotic TNFR1 signalling. A schematic overview of TNFR1 signalling is given in
The TNF-related apoptosis-inducing ligand (TRAIL) was discovered in 1995 by searching expressed sequence tag databases with a sequence from a conserved region of TNF family members [
TRAIL can bind to at least five different receptors: beside the two apoptosis-inducing receptors TRAIL-receptor-1 (TRAIL-R1, also DR4 or TNFRSF10A) and TRAIL-R2 (DR5 or TNFRSF10B), two additional so-called "decoy-receptors" TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2) exist, both of which are incapable of transmitting apoptotic signals. Lastly, TRAIL can bind to the soluble osteoprotegerin receptor [
Knockout mice for the TRAIL-orthologue MK or the only murine TRAIL-receptor mDR5 [
Recent studies also reported a role for TRAIL in immunity, e.g., in context of
While TRAIL-R4 is restricted to non-apoptotic pathways, TRAIL-R1 and TRAIL-R2 can trigger both, apoptotic and non-apoptotic pathways. To date it is poorly understood why humans evolved two fully functional, structurally very similar receptors for TRAIL. TRAIL-R1 and TRAIL-R2 are actually often co-expressed on the same cell. However, for apoptosis induction, TRAIL-R2 seems to be more important [
Apoptosis induction via TRAIL-R1 and TRAIL-R2 requires death domain-dependent recruitment of FADD and caspase-8. In contrast to Fas and TNFR1, TRAIL-R1 and TRAIL-R2 exhibit already robust DISC-formation at the plasma membrane level and thereby triggers pro-apoptotic signalling. The impact of TRAIL-receptor internalisation on signalling is discussed below.
In line with the observations in the TNF/TNFR1 system, internalisation of TRAIL-R1 and TRAIL-R2 is critically involved in determination of signalling outcome. But in sharp contrast to the TNF/TNFR1 system, the requirement of TRAIL-receptor internalisation for apoptosis-induction seems to be cell-type dependent. In type-I cells, stimulation with labelled ligands resulted in TRAIL-R1 and TRAIL-R2 internalisation via clathrin-dependent and -independent mechanisms with concomitant recruitment of FADD and caspase-8 [
In sum, TRAIL-receptor-mediated apoptosis induction is not dependent on receptor endocytosis under all circumstances. While receptor-associated DISC at the plasma membrane level is sufficient for robust apoptosis induction in type-I cells, TRAIL-mediated apoptosis induction in type-II cells may be strictly dependent on receptor internalisation. A schematic overview of TRAIL-receptor signalling is given in
The gene for FasL is located on chromosome 1q23, consists of 4 exons and spans about 8 kb of DNA [
The receptor Fas (FS7-associated cell surface antigen) attracted considerable interest in the field of apoptosis research since its discovery in 1989, as treatment with Fas-specific monoclonal antibodies induced robust apoptosis in cell culture. The Fas gene is located on chromosome 10q24.1 [
Mice with FasL dysfunction phenotypically present with generalized lymphoproliferative disease (gld). Dysfunction of Fas, either caused by retroviral insertion and subsequent premature termination of transcription or a point mutation in the Fas death domain, causes lymphoproliferation (lpr) in mice [
In immunobiology, FasL and Fas are involved T-cell homeostasis [
The soluble and the membrane-bound form of FasL bind to Fas, but only membrane-bound or artificially immobilised FasL cause robust receptor activation [
Fas-associated apoptotic and non-apoptotic signalling pathways diverge at the plasma membrane level. Apoptotic signalling pathways are internalisation-dependent, whereas non-apoptotic Fas-signalling is independent of receptor internalisation. Fas internalisation occurs in an actin- and clathrin-dependent manner [
Using agonistic, Fas-specific antibodies, receptor internalisation is detected within the first 5–15 min. Fas internalisation after FasL binding has been reported to occur even faster [
The prerequisite for Fas internalisation to trigger the apoptotic cell death machinery raises another interesting question: the physiologic stimulus for Fas is most likely the membrane-bound form of FasL rather than agonistic antibodies or artificially oligomerised derivatives of FasL. Does receptor internalisation also occur under these, more physiological circumstances? Indeed, Fas internalisation was observed in co-culture experiments with cells expressing a non-cleavable form of membrane-bound FasL. The degree of receptor internalisation was comparable to experiments using oligomerised soluble forms of FasL [
Interestingly, Fas internalisation is not the only mechanism involving membrane trafficking to ensure selective Fas signalling. Plasma-membrane distribution of this receptor is regulated by post-translational modifications. Several oxidative and non-oxidative modifications alter Fas association with lipid rafts, which is a prerequisite for robust apoptosis induction. For example, palmitoylation at the intracellular, membrane proximal residue Cys199 grants entry in lipid rafts [
Membrane trafficking events are also important for FasL. Membrane-bound FasL has been shown to be released by exosome-like vesicles into the immunological synaptic cleft. FasL sorting to secretory lysosomes (by promoting entry into multivesicular bodies) is regulated by phosphorylation events in the proline-rich domain by Src family tyrosine kinases (Fgr, Fyn and Lyn kinases) mono-ubiquitination at lysines flanking the proline-rich domain in its cytoplasmic tail [
Taken together, Fas-associated, non-apoptotic signalling pathways occurs irrespective of receptor internalisation, whereas apoptosis induction critically depends on Fas recruitment in lipid rafts and efficient receptor internalisation. A schematic overview of Fas signalling is given in
TL1A was identified as ligand for DR3 in 2002 by searching expressed sequence tag databases and screening of an endothelial cDNA library [
The receptor DR3 was discovered in the search of proteins with sequence similarity to the intracellular parts of TNFR1 and Fas by screening cDNA libraries or using two-hybrid systems [
DR3 expression was first recognised on peripheral blood leukocytes [
Consistent with the important role of TL1A and DR3 in T-cells, a variety of T-cell dependent autoimmune diseases have been found to be driven by this receptor-ligand pair. Especially, the TL1A-mediated expansion of effector T-cells at inflammation sites and allergic diseases in the lung as well as the gastrointestinal tract has emerged from these studies [
Beside autoimmune diseases, a role for the TL1A/DR3 system in atherosclerosis [
At the time of discovery, death receptor-induced cellular suicide was the best studied signalling event triggered by DR3. Ectopic expression of DR3 in HEK293 resulted in substantial loss of cell viability. Observations of membrane blebbing, DNA fragmentation and rescue by cotransfecting the viral caspase inhibitor CrmA were indicative for apoptotic cells death [
First attempts to analyse the intracellular receptor signalling complex came from yeast-two-hybrid analysis, reporting interaction of DR3 with TRADD [
TL1A binding to DR3 resulted in activation of ERK, JNK, p38 and NFκB signalling pathways. In TF-1 cells, apoptosis induction was only detected in the presence of sensitising agents such as cycloheximide or pharmacological inhibition of the antiapoptotic NFκB pathway. In both cases, sensitization towards apoptosis was essentially traced back to impaired TL1A-induced upregulation of the antiapoptotic protein cIAP2, a direct NFκB target gene [
To date, the effects of DR3 membrane trafficking and/or compartimentalization on signalling processes emanating from this receptor are not understood and therefore remain for the most part speculative. Directly underneath the putative transmembrane domain, DR3 reveals several tyrosine residues, although no canonical tyrosine-based internalisation motif (e.g., YXXΦ, where Φ is a bulky hydrophobic amino acid) for clathrin-mediated endocytosis is observed at the first glance. However, a recent study demonstrated existence of YXXXΦ-based internalisation motifs [
In the light of the findings discussed, early concepts reducing receptor internalisation as a simple shut-off mechanism for receptor-associated signalling events nowadays fall way too short. In context of TNFR1 and Fas, receptor internalisation after ligand binding constitutes a key mechanism to ensure signal specificity of these multipurpose receptors. Internalisation after ligand binding is indispensable for robust apoptosis induction, as efficient assembly of the DISC primarily takes place in an intracellular, death-receptor containing compartment. However, non-apoptotic signalling pathways, such as NFκB or MAPK activation, occur already at the plasma membrane level and are independent from cellular receptor uptake. That points to an elegant, spatiotemporal regulation of TNFR1 and Fas signalling. To date, none of these aspects has been sufficiently addressed for the closest relative of TNFR1, DR3.
For TRAIL-R1 and TRAIL-R2, dependency of apoptosis-induction on receptor internalisation differs between cell types. More work is needed to elucidate and functionally characterise pathways involved in internalisation of this receptor-ligand system, especially as TRAIL-receptor internalisation is apparently not exclusively dependent on classical clathrin-mediated endocytosis.
However, the necessity to control signalling outcome by compartment-restricted pathway activation comes at a price. Adenoviruses evolved a sophisticated strategy to ensure survival in infected cells and interfere with TNFR1 internalisation via the viral protein 14.7K, thereby protecting against TNF-induced cell death, a deleterious event for the virus [
An in-depth understanding of receptor signalling regulation, whether by internalisation or other mechanisms, lays the ground for target-restricted therapeutic interventions in a variety of human diseases including malignancy, immunity towards infections and autoimmune processes.
This work was supported by a grant (ReForM-A) from the Medical Faculty of the University of Regensburg awarded to Martin Ehrenschwender. We thank A. Gessner for support and J. Wild and insightful discussions and critical reading of the manuscript.
The authors declare no conflict of interest.
Apoptosis induction in type-I and type-II cells. See text for details.
TNFR1-mediated signalling pathways. See text for details.
TRAIL-R1 and TRAIL-R2—mediated signalling pathways. See text for details.
Fas—mediated signalling pathways. See text for details.


text:
Congrats skanoir!
Congrats Impressive 5500 pageviews. You must be very good with social media.
Big Congrats from Moabit to Kreuzberg, Tobias! You have a great portfolio. Well deserved.
All the best and may your new paw "blacken" real quick
That's just awesome! Great!
+100 that would make work so much easier
Awesome! Congrats!
Great! Congrats!!
Happy Birthday
Hello and welcome to the jungle
Ugo – Rez: "a mean little monosynth"
Rez is a seemingly basic synth, but it's capable of a very wide range of sounds. While Rez has a bunch of cool features, the beating heart of Rez is its filter. It's made from multiple chained filters acting as a single powerful filter and it's highly resonant, providing Rez with its distinctive character. Top that off with distortion, a phaser, various oscillator modulations, delay, and a killer programmable arp and step sequencer, and you've got a powerhouse of a synth in a very small package.
From funky squishes, beastly basses, and screaming leads, to tight arpeggiations, swirling rhythms, atmospheres, bells, and interesting effects, you'll find it all here. Additionally, it comes with two skins – Yellow & Black, or Black & Yellow.

subset: commoncrawl


text:
Separate names with a comma.
Discussion in 'Original Pictures Forum' started by Pressedun, May 17, 2011.
Oh boy, picked up a new mower today... had to after Mr. McGinn raved about how much he liked his!
That sexy machine! I think I need to get rid of another Honda for a 30". I do love my 21
Looks good man. Snapper didn't work aht?
Dude, soon as I got it home, pull cord won't wind back in, throttle wont move down at all and the belt broke, Im kinda thinking they half butted the fix on it and I ain't got time to wait 4 weeks for another round of shop time. I'll get her running again though man.
What BS man, now I feel bad. I never had any problems with those items.
Not your fault man, they had it bout 7 weeks and I had to physically stop in for them to work on it, still had to wait a week after that.
Mr. McGinn might have been raving about the performance of his new exmark 21. But he was ranting when deputy dave put it on its side while it was running..
Heck yes man, I'm hoping that 9 inches saves me some time as mine are mostly wide open back yards that I can't get into. Not to mention you don't have to train anyone to use it... it's too easy, not like a small walk behind!
And the new trailer... in John Deere green to match the logo. Oh boy!


text: Okay I have a dark brown 3 inch long 1.5 inch wide birth mark on my right upper knee. And I was kinda wondering if anybody would know how to cover up a birth mark like that? Because the costume that I'm working on currently requires me to show that part of my leg. Because people who usually see my birthmark think that I got into some kind of accident are something. Any advice would be greatly appreciated :) .


text:
The 'Country Strong' on-screen couple sparks dating rumors after they reportedly got close at HBO network's event on Sunday and left the party together.
"Country Strong" co-stars Leighton Meester and Garrett Hedlund have sparked rumors their on-screen romance is becoming reality - after the pair was spotted getting close at a Golden Globes afterparty. Meester and Hedlund were "inseparable the entire night" at HBO network's event at the Beverly Hilton Hotel on Sunday, January 16, according to UsMagazine.com.
A partygoer tells the website "She wraps her arm completely around his neck and pulls him for a quick peck on the lips," and when the pair called it a night, Hedlund was "massaging her shoulders" as they left the party together.
Meester split with "Gossip Girl" costar Sebastian Stan in 2010. She has previously been linked to Aussie actor Luke Bracey, her co-star in upcoming comedy, "Monte Carlo".


text:
Classic meets modern in Upper Rockridge home
Updated 7:29 pm, Thursday, March 7, 2013
Twice a week, The Chronicle features a home on the Bay Area market that caught our eye for its architecture, history or character. More photos at www.sfgate.com/columns/walkthrough.
Address: 5945 Manchester Drive, Oakland.
Asking price: $2.15 million.
Description: Built in 1996, this five-bedroom, four-bathroom home in the Upper Rockridge neighborhood blends classic designs with modern flair. Handmade bronze banisters, an artisan skylight and a mahogany front door greet visitors in the two-story entryway. Twelve-foot ceilings crown the formal dining room, and a sun porch provides a casual setting for conversation. The master suite offers a fireplace with hearth setting and a walk-in closet. The downstairs has a wine cellar and office, and the multilevel backyard offers areas for planting and entertaining.
Don't miss: Expansive yard with views of the Golden Gate Bridge, San Francisco.
Latest Real Estate videos
Built: 1996.
Size: 4,156 square feet.
For more information: Heidi Marchesotti, Highland Partners, (510) 387-7865, email@example.com.
The Walk-Through is produced by Sentinel Media Services specifically for The San Francisco Chronicle. Send submissions to firstname.lastname@example.com.


text:
Jake Gyllenhaal on the Set of Brothers in New Mexico
Jake Gyllenhaal's Birthday Work Day
Start Slideshow
Jake Gyllenhaal's Birthday Work Day
Jake Gyllenhaal had his twenty-seventh birthday on Wednesday (happy belated!) but his celebration doesn't look quite as much fun as Brad Pitt's was the day before. Instead, Jakey G was hard at work on the set of his new movie Brothers in New Mexico. We're hoping that he'll have a few more loved ones by his side for the holidays next week — whether it be with his sister in NYC or his girlfriend in LA or maybe as one big happy family with both. Hopefully this year won't be as scary as last year when his family was caught in a fire.


text:
Facebook to be honored by GLAAD in San Francisco this weekend
Will become the first-ever social media site to receive a GLAAD Media Award
Facebook may not have been a hit on Wall Street this month but the social network company is tops with the Gay and Lesbian Alliance Against Defamation.
GLAAD will present Facebook with a Special Recognition Award at the 23rd Annual GLAAD Media Awards in San Francisco on Saturday (2 June).
The award is for company's strong stand and leadership around bullying prevention as well as its inclusive options for LGBT users.
'Facebook has set the bar high for ensuring LGBT people have a safe space to connect with friends and family,' said GLAAD President Herndon Graddick. 'GLAAD is pleased to present this award to Facebook in recognition of its efforts to make their platform welcoming to everyone.'
GLAAD notes that after violent anti-gay images and comments were posted on a memorial page for LGBT youth, Facebook worked with them to monitor the highly visible page.
It also launched, in conjunction with several LGBT organizations including GLAAD, he Human Rights Campaign (HRC); the Trevor Project; the Gay, Lesbian, Straight Education Network (GLSEN), the Network of Support.
The award will be presented to Facebook's Andrew Noyes and Sara Sperling by high school student Brittany McMillan. It was McMillan who launched the idea for Spirit Day where participants to wear purple or change their Facebook photo to purple in support of LGBT youth and to stand up against bullying.
Other notable LGBT actions by Facebook: Gives users the options to select 'In a Civil Union' and 'In a Domestic Partnership' for their relationship status; and added Help Center content that provides guidance on how users can help an LGBT person who has posted suicidal material.
The San Francisco GLAAD Media Awards at the Marriott Marquis follows ceremonies last month in New York and Los Angeles. It will be hosted by Glee star Dianna Agron.


text:
Part 2 of 3 Octoberween Guilty Pleasures
In Part 1 I spoke of a particular guilty viewing pleasure so I thought for part 2 I'd dive into the realm of what I usually read during this time of year. Given my interests in the supernatural and the paranormal it is only fitting that I would read about those elements of the unknown. I've been an avid reader since the 5th grade so my drifting toward those themes was not a hard choice to make. I've read all the classics when it comes to gothic horror, fairy tales, myths and legends. But what's captivated me the most about this theme is the origins and tomes that speak of the supernatural creatures that were once thought to prowl within the shadows of the night. Those are the tales I personally like to read: stories that consist of the poor creatures cursed to be werewolves, restless spirits and subject of this blog entry, vampires.
Originally my interest in vampires was born when I watched the original black and white movie Dracula but later was fueled when I stumbled upon that "little known" vampire hunter game series on the NES. Though I can't say I'm really into vampires themselves, I mostly found interest in the extraordinary people who hunted them. But just the same the origins of vampires still fascinated me when I learned more about them at my young age. Dracula and Castlevania were the starting flame that fed my passion in learning more about these unholy creatures of the night. How they lived their lives in darkness, away from mirrors and the ways they contracted vampirism. Their strange abilities to levitate, transform and must feed on the blood of the living in order to continue their unnatural life cycle. Thought to be immortal where no mortal could kill them yet their weaknesses consisting of the wooden stake, running water and the use of holy items.
Though my love for the vampire genre has waned in the recent years thanks to the "bastardization" of vampire lore in my humble opinion (thank you for that Stephanie Meyers) there are at least a few novels out there that try to stick to the traditionalist sense of vampirism despite the Stephanie Meyer wannabe knock offs that overflow the bookstores and ebook sites. Now don't think me too rigid for I do enjoy an occasional modern vampire theme in either book or visual form, but my personal favorite is when novels stick to the tried and true formula of the classic vampire theme. And you can't get any more traditional than with Jeanne Kalogridis vampire trilogy: The Diaries of the Family Dracul.
Consisting of three books entitled Covenant with the Vampire (1995), Children of the Vampire (1996) and Lord of the Vampires (1997), The Diaries of the Family Dracul does something daring that few vampire novels try to do: be the prequels and sister novel to the original Dracula written by Bram Stoker! The books even mirror Stoker's narrative by having the chapters written in the same diary format that's found in the original Dracula. But if you're thinking that imitation is the sincerest form of flattery in regards to this also consider that Kalogridis herself also went the extra mile and considered the historical aspects in creating her trilogy. She researched the entire family line of Vlad the Impaler in trying to make her novels as historically accurate as possible. Bram Stoker might've chosen a real historical figure to play as his vampire but Kalogridis goes further by trying to make it appear that the story is more centered in possible historical fact with bloodline ties to her characters and that of the Tsepesh family line.
The first story, Covenant with the Vampire, tells the tale of Arkady Tsepesh as he returns to his ancestral home of Romania with this pregnant wife, Mary Windham, upon hearing of his father Petru imminent passing. Upon learning of his father's death Arkady must then come to terms in saying goodbye to the life he had in London and take his father's place in taking care of his uncle's estate, his spinster of a sister Zsuzsanna, and help his wife prepare to bear the continuing generation of the Tsepesh line. Upon his return to his old life he begins to suffering visions and flashbacks of family tragedies of long ago as well as continuing to come to terms of his new role as overseer of the family estate's business. At first life seems to get back to normal (despite the mutilation of his father's corpse during his wake, caused by "superstitious peasants") but as Mary's pregnancy comes closer to its due time, Arkady beings to be visited by the ghost of his long dead brother Stefan as if to warn him of the horrors to come. He also begins to notice the odd happenings around the estate with visitors vanishing only after a few days upon arriving, the sudden decline of his sister's health and the fear/distain he receives from the townsfolk though he originally brushed those events off as an attack on the nerves or being that he's of the aristocracy. But when he begins to notice the oddities of his Uncle's actions, from how he deals with the locals as if he were still a Lord and they mere "serfs" to his odd hours of only being available during the night hours, Arkady begins to wonder if there was more going on in the castle than he realizes. As Arkady begins to unearth the truth about his family and his Uncle's intentions does he then only come to grips with the true horror of his and his future son's destiny as being a part of an unholy covenant with a vampire.
Out of the three this book is my favorite. It tells the tale of what life was like before the events that transpired before the novel Dracula. Of an estate and castle that still looked livable, with actual servants present to tend to the house. But what I liked the most out of this book was the character development of all the characters involved. They all felt and reacted as real and as normal as you'd expect from the time era that the story takes place. It even feels that you're transported back in time to the dark ages as you learn the truth of what really goes on in Uncle's closes off living chambers…
The second book, Children of the Vampire, continues the story several years where the first left off after Arkady fails to stop the covenant and now shares the fate of his family line. As much as I'd like to go into much broader detail like the first book I dare not for fear of spoiling all that transpires. All I can mention is that this book begins to tell the tale of how the family estate begins to fall apart as well as the consequences of Dracula breaking the covenant, what becomes of Arkady's child as he grows up with his own personal tragedies, introduces the Van Helsings and why the hunt Dracula, and tells the tragic fate of Arkady as well as a new hero rising forth to hopefully end Dracula's existence. I didn't like this book that much though it was mostly because it covered more of the story of Arkady's son, Stefan and all that happens to him and his brother Abraham Van Helsing as they themselves get caught up in the covenant and do their best to save themselves from meeting the fate of so many other Tsepesh before them. The plot twist between Stephan and Abraham is particularly enjoyable. It does it's best to continue where the last book left off but it lacked that certain urgency that was in the last book. Though it did continue to focus on the family drama I was mostly hoping we'd have more direct action taken toward Dracula though the introduction of Arminius and the training Van Helsing in becoming the famed vampire hunter helps take the edge off, as well as getting an explanation on where exactly this covenant comes from. Also there is a scene in the book where Dracula tortures a French dandy who goes by the name "Jean Belmonde". I'm not sure if that name was coincidence or intentional by the author…
The third book, Lord of the Vampires, tries it's best to take place during the exact same time as the original Dracula novel. It tells of the events that actually transpire during the same time in the book but from a different perspective. It adds a layer of knowledge that helps to explain better where Dracula got his vampire maidens, his real reason why he left for London, and what actually happened in pivotal moments in Bram Stoker's Dracula. From the seduction of Jonathan Harker, to Lucy's blood transfusion, to the final battle on the Borgo Pass, this book tells of what exactly happened despite some characters doing their best to "sugarcoat" the events in the novel Dracula. The book also introduces the famed Countess Elizabeth Bathory of Csejthe into the plot along with speaking of her own covenant and what she has to do to maintain it. Though the book does its best to tell the "real" story behind the novel Dracula, it falls flat when it reaches the end. Plus the story also loves to throw out unexpected plot twists that don't explain themselves fully, thus adding more confusion to the story when I'm sure it was intended to be shocking revelation that's supposed to explain everything. I thought the ending was really lame when it came to the fate of the Tsepesh bloodline, the big reveal of who Arminius truly was and the true fate that befell both Elizabeth and Dracula.
Despite all of this I would still rather read The Diaries of the Family Dracul Series than any of the current dreck out there that passes for a vampire novel. Despite knowing all that will happen I still find enjoyment in reading these novels over and over again during a dark night as a warm fire burns in my fireplace, me wrapped in my red robe with a warm drink by my side. The books have a way of teleporting you back to that time era and feels refreshing yet having an air of agelessness about it that speaks of the setting that no current vampire novel's flashback scene could ever touch.
So I bet your wondering why if this series is so good why I would consider it a guilty reading pleasure. Mostly it's because of the very thing that plagues me whenever I try to read/watch/listen to any form of media: the inclusion of sex. Though I wouldn't consider myself a prude when it comes to such things, I just don't like having that personal aspect in my consumable media. I'm more of a violence and killing man myself so I'm not really into reading about one's sexual exploits in graphic detail. Also made worse is the fact that most of the sex scenes are either done out of incest or have a lesbian angle toward them. Though there is a reason why the sexual acts of incest and lesbianism occur (the events in question are mostly between Zsuzsanna and Dracula along with other family members as well as Zsuzsanna and Elizabeth) I could live without reading exactly what they did in exact detail and how they felt as they did such. The books even go as far as having an affair sex scene between a brother and his brother's wife, a threesome that involved three women and a different scene with two women and a man, a scene of necrophilia and a prostitute sex scene that ruins the visual image I have of Santa Clause.
If I had the nerve I'd rip out those pages but my love for books prevents me from mutilating them. Now if it was a novel written by Shakespeare….
Despite the inclusion of graphic sex scenes, they don't quite border into the realm of romance novels or other modern vampire hunter novels out there. The bulk of the series is able to overshadow the negative aspects I found in them to make the books almost tolerable for me to read without throwing the books away in disgust. I enjoy reading them yet at the same time I get a twinge of guilt as I read into them even when I skip the sex scenes. I've been told I shouldn't feel guilty when I read but if there wasn't a better candidate to be considered as guilty reading pleasure, I'm not sure what series that would be fit that description better than this one.
The Diaries of the Family Dracul Series: Covenant with the Vampire, Children of the Vampire and Lord of the Vampires can be found anywhere books are sold/found.


text:
Hey everyone
Bit random here but though I would make use of the Global Off topic. I know everyone has different tastes and genres of music they like but does anyone have like a specific song they listen to when they're designing or creating any-sort of work?
For me its gotta be any of the chemical brothers songs….. Just gets me in the mood
Those are the ones for me at the moment ,
Great Deep Purple
And a true idea generator Vivaldi
-> Vivaldi +1
Majestic and inspirational classic – link.
Gramatik – Muy Tranquilohttp://www.youtube.com/watch?v=FZK9Zi26Izc
Back when I was in engineering I loved to design listening to this type of thing!http://www.youtube.com/watch?v=UUE39OjktgQ
Funny because I'm not really a goer of nightclubs and also not the type of music I normally write or play either but when i was drafting building designs and blueprints this is what i listened to!
quickandeasy said
Nice Thanks for the tip.


text:
Human endoskeletons are inside the body, unlike the exoskeletons of lobsters, grasshoppers, and piñatas. Protect your skeleton with this Groupon.
Choose Between Two Options
$39 for a chiropractic package (a $455 total value)
- Consultation and exam (a $115 value)
- Four x-rays (a $200 value)
- 30-minute massage (a $35 value)
- One chiropractic treatment (a $105 value)

$59 for a chiropractic package (a $560 total value)
- Consultation and exam (a $115 value)
- Four x-rays (a $200 value)
- 30-minute massage (a $35 value)
- Two chiropractic treatments (a $210 value)

Doctor of Chiropractic Tran Khuu customizes treatments based on consultation and exam. Treatments may include decompression, muscle stimulation, stretches, or adjustment with the ProAdjuster.
Essential Health Center
In an office peppered with lime-green-accented exercise equipment, Doctor of Chiropractic Tran Khuu](http://gr.pn/ebVBOh) smoothes spinal curvatures and rids bodies of chronic pain without drugs or surgery. Her consultations help pinpoint spinal trauma brought on by past injuries or weeks spent folded inside the glove compartment. After thorough corporal documentations, she constructs treatment regimens tailored to individuals' wellness goals. She uses a ProAdjuster tool to make adjustments, instead of manipulating bodies by hand.


text:
It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....
Reflex Sympathetic Dystrophy (RSD) (CRPS) Message Board
A good, safe dosing for rsd pain
All times are GMT -7. The time now is 09:43 AM.
Site owned and operated by HealthBoards.com


text:
Satanist who raped three girls, took pictures, going to prison
A self proclaimed satanist, who on social media used the screen name "The Lord of Darkness," has been sentenced to 95-years in prison for molesting three little girls, taking pictures of the assaults and then trading those images online with other child pornography collectors.
Luis Moreno, 31, was charged with 12 counts of production of child pornography, two counts of the receipt of child pornography and two more counts of the possession of kiddie porn.
"This case is especially serious because of the number of victims. He lined them up on the couch and called them back up, one by one," Assistant US Attorney Tracy Thompson tells 1200 WOAI news. "One of the older kids would sit there, knowing what was going to happen to her, but just having to sit and wait until her name was called."
One of the victims told FBI investigators that Moreno would "stick his middle part into her middle part," while the pair were in a room called "the princess room."
The case was a joint investigation by The San Antonio Child Exploitation Task Force involving the FBI and the Bexar County Sheriff's Department.
Assistant US Attorney Tracy Thompson said investigators were originally tipped off to Moreno when they busted another pervert in Indiana. They asked to assume his profile online. That's when agents received dozens of emails filled with illicit pictures from Moreno.
"He has been sexually assaulting these three minor females for six years," she told the judge.
Moreno's mother, Herlinda Flores, testified that her son has been diagnosed with bipolar disorder and schizophrenia.
"He did not have insurance so he could not afford the medication," she told the judge, who later rejected the defense.
The case was difficult for agents because Moreno is basically a drifter who lived in different homes. He did not have a computer. Instead, he created the child pornography using a HTC Mytouch 4g cell phone, a pink Nintendo DSI video game system that belonged to one of the victims and a Hotmail email address. They eventually caught up to him in a seedy apartment on Grayson Street, not far from the entrance to Ft. Sam Houston.
Moreno, who had tattoos of a pentagram and the Grim Reaper up and down his body, has a lengthy criminal history, including Aggravated Assault with a Deadly Weapon in in 1999. He attacked a girlfriend with a samurai sword.
The three victims, who were all attacked when they were three years old, are all in protective custody. Their current guardian told the judge that they received counseling at one point.
"They're doing okay," she testified.


text:
Gilbert Gray
Southern Yacht Club/1932 Olympics
Inducted: 1977
Won the 1932 Olympic Star Class championship and flew the Southern Yacht Club pennant in 28 Lipton Cup regattas, winning a record 12 times.
Won the Sugar Bowl's Race of Champions five times.
In the seven-race Olympic series, tallied five first-place finishes, one second and one third.


text:
An unrelenting emphasis on standards, competitive sport, a no-nonsense approach to discipline, strong communication with parents ...
These are claimed as the ingredients in the success of the London borough with the best primary school results in the country.
But if all this had to be distilled into a single attitude of mind, the strongest impression given by the education head at Richmond-upon-Thames is a policy of "no excuses".
Geoffrey Samuel, cabinet member for schools in the south-west London borough, keeps returning to the theme that there is no reason why a school should not be expected to deliver a decent level of education for its pupils.
"You can go to some boroughs where the first thing you'll hear about is the poverty and social problems that their pupils face .. and I think that's a misjudgement."
A former comprehensive school head teacher, Mr Samuel says that schools should not allow the social disadvantages of their pupils to continue a cycle of educational failure.
"It can allow a tolerance of underachievement, where schools say 'what else can you expect from pupils with problems like that'. My reaction to that is to say 'tough'."
"You have to be ruthless in your ambition for your pupils. They only have one life. If a child wants to be a vet, and they go to a school where there is no record of getting good academic results, their chance of getting what they want can be lost forever."
'Lost direction'
Richmond might have more than its fair share of leafy streets and affluent homes, but he says that for poorer areas to allow their social circumstances to be used as an excuse for poor academic results is a great disservice to those who most need a good education.
Now deputy leader of a Conservative council, Mr Samuel, who was also once a Labour councillor, is scathing about the state of education in the capital in recent decades.
And he says that the extremes in differences between authorities in the capital reflect an era when many schools lost their sense of direction.
"From the late 70s, standards dipped phenomenally. Schools were unfocused, untargeted, filled with unclear waffle.
"Education in London has gone through an appalling 25 years, in which it has been subordinated to a social agenda.
"It was a betrayal of education, and that's the reason why there are such extremes in London schools. And it will take another 20 years to reverse."
'No short-cuts'
The length of time it takes to make a difference is emphasised by Mr Samuel, who criticises successive governments' pursuit of quick fixes and headline-grabbing initiatives.
There are no short cuts, he says, progress has to be measured in decades. And throwing money at the problem won't deliver immediate results.
"It's not just a question of more money. It's easy to say we need to pour in more money, but that's simplistic and it won't necessarily lead to improvements.
"Issues such as good discipline and a clear structure can be more important."
Parents are also a vital part of the equation, and he says they are often very traditional in their expectations of how a school should be run.
"If parents and schools are on different wavelengths it can be very difficult. But it's a challenge that many schools duck.
"When I was a head, most of the pupils were from Indian families, and their parents wanted a traditional education, with a strong sense of discipline.
"Parents respond to a very clear value system and schools have to make their intentions absolutely clear. Even if they can't control their own children, parents want the teachers to."
Parents also like team games and competition, he says, and the borough supports the idea that competitive sport is a good thing.
Schools benefit from a shared ethos and sense of purpose, he says. This has contributed to the success of faith schools, he says. But this sense of distinctiveness can rub off on specialist schools, where he says, schools gain their own character and "flavour".
"It's like a business, where everyone from the cleaner through to the managing director know what the company is about. That translates into results."
And too often in the past, he says that too many London schools didn't really know what they were for.
House prices
In the case of Richmond's primary schools, this tough message has put the authority at the top of the league table in successive years for the tests taken by 11 year olds.
This makes places in the authority's primary schools highly sought after - perhaps adding £50,000 to the price of houses in the right catchment areas.
It might be expected that the triumphs of the borough's primary schools would convert into similar success at secondary level. But it's not that simple.
Because compared to the national average for GCSEs, the borough's secondary school results are struggling.
And many of the social factors of affluence and motivated parents that contribute to the borough's success in primary schools exert a pressure in the opposite direction at secondary level.
Put simply, if parents can afford a big house in a leafy part of the borough, they can also probably afford to send their children to a private school.
And more than a quarter of pupils in the borough do that.
There will be other parents who then send their children to schools "over the border" in neighbouring boroughs - so that only about 60% of pupils in Richmond's secondary schools are from the borough.
In practice, this means that many of the brightest children from middle-class families opt out of the borough's secondary schools, creating some of the problems stereotypically associated with more deprived quarters of the capital.
And as with the most deprived boroughs, schools with poor results won't attract the motivated parents who can help drive up results - and such cycles are difficult to break.


text:
#25 Rib and Bobble Vest by Pat Olski
Welcome! You are browsing as a guestWould you like to see 7 projects made from this pattern and much more? create a free account What am I missing?
© Vogue Knitting
#25 Rib and Bobble Vest
Errata available: vogueknitting.com
This layered look plays with shade, shape and stitch. The long emerald vest carries a waist detail featuring ribbing, cables and bobbles.


text:
Short Shorts
Althea's shorts WERE hella tight and small, though. This was a family barbecue, right?
I was looking at Scrappy's shirt and just SMDH….this GROWN A$$ man walking around with a shirt on that should say COCA COLA (no better), but his says CR@CK. Well, look who we're talking about. Where they do that at?
What u expect? With a mother like momma dee scrappy never had a chance. Smh
thats not a benz hiphop wired


text:
Why Nicolas Anelka should serve a ban following his quenelle celebration
Earlier in the week, a colleague of mine asked me what I was going to say about Nicolas Anelka's quenelle gesture in this column.
I replied that I didn't intend to touch the subject with a barge pole, firstly because it's such a complicated issue and secondly because I had some sympathy with him and was keen to avoid coming across as anti-Semitic.
I had sympathy with Anelka because I bought his story that using the gesture was meant as a way of showing his support for his friend, comedian Dieudonne M'bala M'bala, rather than anything more sinister.
In addition, I'm pretty sure that most people in this country will have been slightly non-plussed when they saw the gesture, so how could it offend anyone?
However, as the week went on and I looked a little deeper into the issue, my sympathy for Anelka has waned.
Whether or not M'bala M'bala, who invented the gesture, meant it to be anti-Semitic, I'm not sure. However, it is pretty clear that it has become just that in France, with people performing it outside synagogues and, disgustingly, at former concentration camps such as Auschwitz.
I'm still happy to believe that Anelka is not a racist and made the gesture in support of M'bala M'bala – but I no longer think that this is a good enough excuse.
He must have known that people, especially in France, would be aware of the gesture's anti-Semitic connotations, so surely he is guilty of making an "abusive" sign and deserves to be punished for it.
Worse still, he is almost single-handedly responsible for introducing the gesture to this country. Its connotations may be ambiguous over the channel, but I have a horrible feeling it will be adopted by racists in this country to show their feelings of anti-Semitism.
Providing these idiots with another means with which to abuse people is perhaps Anelka's biggest crime, regardless of his intentions.
The FA has taken a lot of stick for allowing the saga to rumble on while they investigated – but I do have sympathy with them. It is a very complicated issue, with a mountain of grey areas, and they needed to get their facts right before they charged the player.
Assuming he is found guilty, they now have to work out how long to ban him for – but that's a whole other story.
Does bobsleigh really merit more than £3million in funding?
I had a look at the amount of funding various sports received in the build-up to the forthcoming Winter Olympics and was amazed to see that bobsleigh and skeleton were top of the charts, with each receiving more than £3million.
To be fair, this seems to be in line with the summer Olympic sports, it's far less than the likes of athletics and rowing get for example.
However, does that mean that UK Sport is right to plough so much money into these sports? I'm not sure.
In my opinion, at least part of the criteria for funding sports should be to encourage the general public to participate – something that, frankly, isn't going to happen with these sports.
In contrast, figure skating, a far more accessible sport, got less than £200,000 in funding. Yes, we have a decent record at skeleton, but surely, given the same funding, we could become more successful at figure skating, a sport that is available to far more young people.
Why selling Juan Mata to Manchester United is great business for Chelsea
As a Chelsea fan, you may expect me to be unhappy with the sale of Juan Mata to Manchester United – but I think it's a great deal for the club.
Yes, the Spainard was the club's player of the year for the past two seasons, but he has been reduced to playing a bit-part under Jose Mourinho.
The bigger problem may be that Chelsea are helping United by selling them a player of his class – but there are about 37 million reasons why this shouldn't be an issue.
With the emergence of Willian, Mata is clearly surplus to requirements at Stamford Bridge. Selling him to a rival isn't ideal, but United have paid a premium, partly for that reason. Nobody else would have paid so much to get him.
The advantage to Chelsea is two-fold. Firstly, they need the money to balance the books when FIFA's financial fair play restrictions come into place. Secondly, they can use the money to buy players in areas where they are lacking, rather than paying high wages to Mata, who occupies a position where they already have an embarrassment of riches.
What do you think? Have your say by using the comment box below or Tweet me @JBoymanGaztte.


text:
"Get 22 times more inquiries than Free Members with a Gold Supplier Membership!"
Author: Mr. Zohaib Akhtar
If you believe an article violates your rights or the rights of others, please contact us.
I found real gold on Alibaba.com with Gold Membership and Quality RFQs
Today, 80-90% of our export business comes from customers referred by Alibaba only
I am receiving 100% export business through Alibaba.com
We believe that ecommerce is guiding our company to another level of success !
We were so eager to reach more overseas buyers and Gold Supplier membership definitely achieved this for us


text:
Posted on » 13 April 2010
More than 500 Toastmasters from 24 clubs around Bahrain will take part in the Bahrain Toastmasters Annual Conference - Division K.
It is being held on Friday at the Bahrain Society of Engineers, Juffair.
It will feature competitions in evaluation, humorous, table topics and international speech.
A total of 20 participants, who are all reigning champions from their own clubs, will battle it out to become BTAC-K Champion in each of the four categories. Winners will go forward to compete in the District Toastmasters Annual Conference in Kuwait next month.
This year's conference will also include for the first time a panel discussion involving some of Bahrain's most distinguished industry leaders, said organisers.
They include Tamkeen chief executive officer Abdullelah Al Qassimi, Eastern Industrial and Oilfields Holding Company chairman Hussain Tadayon and Bahrain Institute of Banking and Finance's academic and executive centre head Mohammed Alkhozai among others.
The discussions are entitled Communication and Leadership towards Bahrain's Economic Vision 2030.
Pre-registration is required for the event.
Contact Division-K Governor Alex Ginete on 36705956, event chairman PB Dinesh on 39117907 or Public Relations Committee head Ayla Ginete-De Leon on 39240998 for further details.


text:
India-born guitarist/vocalist Roly Daniels is one of the most successful country and western artists in his adopted home of Ireland. The recipient of a lifetime achievement award from Irish World newspapers, Daniels ahs recorded such hits as "Hello Darling", the "Fighting Side Of Me", "Sunny Tennessee", "He Stopped Loving Her Today" and "Mr. Jones".
Although he maintained a low profile during the early-1990s, performing only rarely in public, Daniels returned to the stage as part of a touring revue, Hucklebuckin' Again, with Brendan Bowyer and Butch Moore, accompanied by siblings Keith McDonald on trumpet and Lorraine McDonald on saxophone and flute, and their group, the Showband Show. Since the tour's conclusion, Daniels has continued to tour with Big Chief (Flaming Star) and the Showband Show.
Born in Jubbulpore, India, Daniels grew up in Dublin, Ireland. Initially performing with the Memphis Showband, he later played with the Nevada Showband. He remains one of the top international country and western entertainers in Nashville, Tennessee.


text:
'The WotWots' Expands in Turkish and Russian Markets
Pukeko Pictures' The WotWots Expands in Turkish and Russian Markets with a Home Textiles Deal with Zorluteks Textile
Wellington, January 29, 2014 - The WotWots from Pukeko Pictures is expanding its presence in Turkish and Russian markets following a home textiles deal with Zorluteks Textile.
The Zorlu Textiles Group is the leader of the Turkish home textiles sector with its TAÇ-branded products. The group is a leading maker of home textiles with giant manufacturing capabilities and world-famous brands including TAÇ, Linens, and Valeron. Zorlu Textile holds the home textiles licenses on dozens of famous cartoon and other characters in many countries, and controls an important share of the licensed products market as well.
The Turkey based licensee will represent the popular preschool brand's home textiles range including bed linen, duvets, bed skirts, pillow cases, comforters, curtains, bath towels, terry cloth robes, polar fleece blankets, acrylic blankets, plush cushions, ready beds and window shades in Russia, Ukraine, Kazakhstan, Azerbaijan, Georgia, Moldova, Belarus and Turkey.
"The home textiles category is one that is extremely popular with preschoolers so we are delighted to now be offering a broad range of DottyWot and SpottyWot themed products across these territories. The WotWots brand continues to be universal in its appeal and a popular preschool choice for both children and their families," said Andrew Smith, Chief Executive Officer, Pukeko Pictures.
The WotWots is an enchanting preschool series broadcast in over 90 territories that follows the adventures of two adorable siblings from outer space, SpottyWot and DottyWot. This delightful pair of inquiring minds have come to Earth to explore and to marvel at the extraordinary diversity of life on the blue planet. The show celebrates this joy of discovery and demonstrates the positive values that are the building blocks of a true and enduring friendship.
Season one sees SpottyWot and DottyWot come to explore planet earth in their steam-powered spaceship and arrive in the middle of a zoo. In season two, the alien siblings land on a farm and meet strange and friendly farm animals and also travel to the seashore. Encouraging the love of animals, the season celebrates the joy of discovery and the extraordinary diversity of life on the planet.
About Pukeko Pictures
Pukeko Pictures is an independent entertainment production company, focused on the development and production of excellent quality, multi-platform entertainment for a global audience. Pukeko Pictures was founded in 2008 by Sir Richard Taylor, Tania Rodger and Martin Baynton, and is located in Wellington, New Zealand. With a connection to the world-famous Weta Workshop (Avatar, King Kong, Lord of the Rings), Pukeko Pictures is uniquely positioned in the creation of world-leading entertainment, harnessing the best in global talent and world-class production processes.


text:
This product has been retired from our catalog and is no longer for sale. This page is made available for those looking for datasheets and the simply curious.
Description: Replacement: None. We don't carry a direct replacement for this part but check out our accelerometer category for more dual-axis sensors. This page is for reference only.
This is the bare ADXL32x accelerometer sensors from Analog Devices. The ADXL32x outputs analog voltages and can be powered from 2.4V-5.25V. The Self-Test pin can be used to verify sensor operation.
Note: We found these in inventory and they work fine but we're no longer stocking them. We'll be selling them at a discount for a limited time but when they're gone, they're gone!
Available Sensors:


text:
|You are in: World: Europe
Wednesday, 20 March, 2002, 11:20 GMT
Inside Italy's growing refugee camps
A group of almost 1,000 illegal immigrants who landed in Sicily on board a cargo ship has been moved to the Italian mainland.
After a week spent travelling in the most wretched conditions, the refugees' home - for the moment - is rows of shabby caravans.
Inside the main part of the refugee centre, hundreds of migrants queue as volunteers rip open boxes filled with blankets.
This part of south-east Italy has grown used to becoming a gateway to Europe for the needy and fearful.
The immigrants, who are thought to be mainly Kurds, are expected to seek political asylum.
"Iraq is very dangerous, we cannot live in Iraq," one man told me.
The people now crowding inside this converted tennis court have become pawns in Italy's political games. Opposing voices within the government have expressed very different views over the ayslum issue.
But local officials in Bari are keen to show that their instincts are overwhelmingly humanitarian:
"We only want to help these people", said Mario Giangrande of the local Prefect's office, "and make sure they live in the very best conditions."
At the other end of the building, Roberto is providing service with a smile as he hands the refugees trays of what look like limp TV dinners - but which he described with the loving detail of a top pasta chef.
Once they have been given their food they go and sit in rows and rows of white tables.
There are hundreds of them here in front of me, all having their first square meal in several days.
They look pretty shell-shocked, but happy to finally have some hot food.
But as the bureaucratic part of the asylum procedure starts, the authorities here in Italy are mindful that these people have been brought here for a price.
One man told me he had paid $3,000 for the chance of a better life.
And with ships filled with more refugees rumoured to be heading for Italy, the reception centre here is bracing itself for a fresh influx.
See also:
19 Mar 02 | Europe
Destination: Europe
04 Jul 01 | Europe
Immigrant ship rescued off Italy
16 Jun 01 | Media reports
Divers locate 'phantom shipwreck'
23 Apr 01 | Europe
Illegal immigrants disembark in Italy
20 Mar 02 | Europe
Analysis: Italy's asylum struggle
Internet links:
The BBC is not responsible for the content of external internet sites
Top Europe stories now:
Links to more Europe stories are at the foot of the page.
Links to more Europe stories
|^^ Back to top
News Front Page | World | UK | UK Politics | Business | Sci/Tech | Health | Education | Entertainment | Talking Point | In Depth | AudioVideo
To BBC Sport>> | To BBC Weather>>
© MMIII | News Sources | Privacy


text:
Posted by Jennifer
Mr. Street is thorough, caring and responsive. He works hard, seems to enjoy his job, is not callous nor cynical of the system and was very respectful of my needs and the needs of my children. He helped me through a very lengthy and messy divorce which included domestic violence and custody issues. He always returned phone calls even after hours and I knew he was sacrificing precious family time to do so.


text:
But forget about the tertiary side characters, the main players are also saddled with catastrophically absurd stories as well.
My only consolation is the knowledge that the speaker is entirely secondary (or tertiary) to the proceedings.
Brongniart, to show a transition character between the vegetation of the secondary and that of the tertiary formations.
We have seen that it is a state of tertiary formation and very complex.
These rounded knolls are all that denudation has left of the tertiary sand deposits on the chalk.
tertiary Colours are three only, citrine, russet, and olive.
This is seen at the junction of the tertiary beds with the chalk near London.
No trace of the family has yet been detected in even the tertiary rocks.
Post′-pos′itive; Post′-remote′, more remote in subsequent time or order; Post′-ter′tiary, more recent than the tertiary.
The tertiary period had also its prominent class of existences.
1650s, "of the third order, rank, degree, etc.," from Latin tertiarius "of or pertaining to a third," from tertius "third, a third," from root of tres "three" (see three). The geological sense (with capital T-) of "era after the Mesozoic" (which formerly was called the Secondary) is attested from 1794, after Italian terziari, used in this sense 1760 by Italian geologist Giovanni Arduino (1714-1795).
tertiary ter·ti·ar·y (tûr'shē-ěr'ē)
Third in place, order, degree, or rank.
Of or relating to salts of acids containing three replaceable hydrogen atoms.
Of or relating to organic compounds in which a group is bound to three nonelementary radicals.
Noun Tertiary. The first period of the Cenozoic Era, from about 65 to 2 million years ago. During this time the continents took on their present form, and the climate changed from being warmer and wetter, in the early part of the period, to being drier and cooler in the later part. Mammals replaced dinosaurs as the dominant form of terrestrial animal life, and many modern types of flowering plants, insects, mollusks, fish, amphibians, reptiles, and birds appeared. The Tertiary is subdivided into the Paleogene and the Neogene, although these terms are not as widely used as are the names of the epochs that constitute them. See Chart at geologic time.


text:
Brunswick Mothballs Knoxville Boat Plant
Brunswick Corporation (NYSE:BC) announced on Jan. 6 that it will mothball its Riverview boat manufacturing facility near Knoxville, Tenn., and take additional actions aimed at reducing its work force, production and expenses. One of three manufacturing facilities in the Knoxville area, Riverview makes Sea Ray boats and will wind down production during the first quarter of the year. To better utilize Brunswick's overall boat making capacity, production at Riverview will be moved to nearby plants in Knoxville and Vonore, Tenn., which will remain in operation. In addition, production of certain models will be transferred to Brunswick's Palm Coast manufacturing facility in Florida, and a Brunswick plant in Reynosa, Mexico. The final impact of these production shifts on staff levels at those locations, if any, is still being determined. At year-end 2008, Brunswick employed about 1,500 people in the Knoxville area. Approximately 300 production and support positions at Riverview will be idled by this action over the coming months. The company said it will work diligently to transfer as many Riverview employees as possible to the nearby Knoxville and Vonore manufacturing facilities. By mothballing this facility, Brunswick retains the option of restoring production should market conditions reverse and improve.
MMS to Hold Public Hearing in Mobile
The Interior Department's Minerals Management Service (MMS) will hold a public hearing in Mobile, Alabama on Wednesday, November 1, 2006 to solicit comments on the Draft Environmental Impact Statement (DEIS) for the Proposed 5-Year Outer Continental Shelf (OCS) Oil and Gas Leasing Program for 2007-2012. The hearing will be held at the Riverview Plaza Hotel, 64 South Water Street, Mobile, Alabama at 1:00 p.m. Statements on the DEIS, both oral and written, will be recorded
Transportation Industry Executive, Gerald P. Toomey, Dies at 73
Transportation industry veteran Gerald P. Toomey died on Monday, November 19, at the Riverview Medical Center in Red Bank, NJ. He was 73. During his long tenure inthe transportation industry, Toomey was best known for his contributions at Sea-Land Service, Inc. where he worked from 1963 until 1974. There, he was instrumental in the development of the company's Puerto Rico and Caribbean trades, and he ultimately served as Sea-Land's group vice president, Caribbean
BOEMRE's Draft Supplemental EIS, Central GOM Lease Sale
The Bureau of Ocean Energy Management, Regulation and Enforcement (BOEMRE) today released a Draft Supplemental Environmental Impact Statement (SEIS) for proposed oil and gas Lease Sale 216/222 in the Central Planning Area in the Gulf of Mexico. The draft SEIS updates the findings in several previously published environmental reviews covering the Gulf of Mexico and incorporates the latest available information following the Deepwater Horizon explosion and oil spill.


text:
The suits allege that Facebook provided false and misleading statements in documents filed with the Securities Exchange Commission and made available to the public prior to the stock offering. In addition, according to the lawsuits, the company allegedly gave a private heads-up to lead underwriters, including Morgan Stanley and Goldman Sachs, who then decreased their revenue projections. The lawsuits allege that the underwriters told a handful of select investors about the change, but not the public.
The class action suits, two of which were filed in San Mateo Superior Court, call for compensatory damages. Case management conferences have been scheduled for July 25 and Oct. 4.
Facebook's stock continued to decline as news of the lawsuits circulated. By Friday the price had dropped to $31.75 per share, after opening on May 18 at $42.05 on NASDAQ.
May 29: Final hearing on Facebook expansion
Bucking its trend of taking Tuesday night off after a holiday weekend, the Menlo Park City Council convenes on May 29 to review the final environmental impact report for Facebook's planned campus expansion.
The report examines the potential community effects of Facebook's plan to hire up to 6,600 employees at its 1 Hacker Way "East" campus and make improvements to all its properties, including those on the Constitution Drive "West" campus. The report also proposes mitigations for traffic and other concerns.
The Planning Commission voted unanimously on May 7 to certify and forward the report and associated documents to the council for approval.
The regular meeting starts at 7 p.m., following a closed session to discuss unidentified potential litigation at 6 p.m., in council chambers at the Civic Center at 701 Laurel St.


text:
This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Find out more here.
Talk to us about diabetes
0345 123 2399
Talk to someone about diabetes
If your child has been diagnosed with diabetes, you may be feeling overwhelmed and worried. Diabetes UK aims to provide you with the information to help you and your child manage their diabetes together. See below for help and advice, from dealing with diagnosis and finding suitable childcare to speaking to teenagers.
Being diagnosed with diabetes can sometimes feel overwhelming, and may throw up many questions about how the condition fits into your daily life.
Find out more
For the parent, as for the child, the diagnosis of Type 1 diabetes is likely to come as a most terrible shock. As a bolt from the blue.
Advice and tips on using insulin to treat your child's diabetes.
Information on blood glucose, hypos and hypers, diabetic ketoacidosis, thyroid tests and more.
Advice for lone parents, separated parents and for keeping the peace between siblings when one of them has diabetes.
Information and advice for when someone else is looking after your child.
Physical activity is an important part of a healthy lifestyle.
There are no hard and fast rules about brining up a teenager with diabetes, but we have some advice and tips that may help.
Diabetes UK is passionate about making sure children with Type 1 diabetes get the care they need in the classroom.
Diabetes UK's website for children and young people. Info, support and fun stuff.
None of our much-needed work would be possible without your kind support, so please, make a donation now.


text:
Desiree's Expertise Has Been Featured In
Desiree's presence and ability to communicate effectively are second to none. She is always prepared and engaging. Desiree wants everyone she works with to succeed.
— Kathryn Conway
I am BLOWN AWAY! Literally my hair is standing on end from reading how Desiree took my initial ideas and turned them to gold.
— Catherine Just
Desiree helped me go BOLDLY to MY voice and increase the influence my messages have.
— Maurika Wells
I highly recommend working with Desiree if you want to attract and connect to your tribe. This is gold. Desiree, you were meant to do this!!
— Briana Borten
If you are seeking to improve your speaking abilities, your search should begin and end with Desiree Moore.
— Peter Beckmann
About Greenhorn Bold
Through Greenhorn Bold, my mission is to help individuals, entrepreneurs, solopreneurs, and small business owners master speaking and presentation skills, whether in one-on-one conversation, on camera, or in front of live audiences. To help you accomplish this, I have created free speaking and presentation workshops and other resources that will guide you as you connect and communicate with others in ways that truly resonate, and that will attract, influence, and inspire.


text:
The Shakespeare Conference: SHK 22.0116 Thursday, 10 June 2011
Date: June 9, 2011 4:34:22 PM EDT
Subject: Re: SBReview_14: Arden3 MV
Professor Halio writes:
>Regarding the name "Shylock," I am grateful to Drakakis for pointing me to Stephen Orgel's essay, "Imagining Shylock," which argues that the name is not of biblical derivation, but an English name. Orgel traces the name "Shylok" to Englishmen in Hoo, Sussex, as early as the fifteenth century. (This essay came out well after my edition, or I certainly would have noted it, as Drakakis does.) Nevertheless, given many of the other biblical references from the Old Testament, including the names Tubal, Leah, and Chus (or Cush), Shakespeare could have been reminded of Shelah, or Shelach, Shem's grandson, and then Anglicized it. All the names derive from descendants of Noah, including Jessica, or Iscah, although Orgel disputes that derivation as well.<
Indeed, Dr Drakakis (p 165) chooses the Bishop's Bible's 'Selah' over the Geneva Bible's 'Shelah' in his translating Genesis 10:24: "Arpharad begate Selah, and Selah begat Neber." ('Arpharad" may be an Arden3 typo for Bishop's "Arphaxad", and "Neber' an Arden3 typo for Bishop's 'Heber'.) The 1560 Geneva verse in fact reads (with each long 's' modernized and diacritics removed): "Also Arpachshad begate Shelah, and Shelah begate Eber." Dr Halio's Oxford edition (p30) also notes Geneva's "marginal gloss to GEN 10;24" (actually to 10:21's "sonnes of Eber") -- which gloss reads: "Of whome came the Ebrewes or Iewes." (No doubt Dr Halio has by now been alerted to his edition's misciting on p 22 'Rachel' rather than 'Rebecca' as "obtaining Esau's birthright for her other son.")
Earlier Dr Drakakis (p 89) has John Coolidge arguing that "Jessica's elopement is a repetition of Jacob's absconding with Leah." In fact, Coolidge's 1976 piece (p 247) has Jacob absconding with both "Rachel and Leah." Rachel, having stolen her father's idols (like Jessica her father's jewels) may be an even closer counterpart to Jessica than Leah.
Congratulations to both Profs. Halio and Drakakis for their superb works of scholarship.
Joe Egert
SHAKSPER: The Global Shakespeare Discussion List
The SHAKSPER Web Site <http://www.shaksper.net>
DISCLAIMER: Although SHAKSPER is a moderated discussion list, the opinions expressed on it are the sole property of the poster, and the editor assumes no responsibility for them.


text:
About kpi.com
Finnet Ltd, the firm behind the kpi.com™ product, is privately held and incorporated in the UK. Established in 2004, Finnet Limited engaged in offshore software development, web design, data analysis, benchmarking and research services to a handful of strategic digital media clients. In 2007, having realised the potential of SaaS and the Cloud, Finnet Limited decided to move away from services model to investment in the development of a Cloud-based SaaS B2B product portfolio. This product, kpi.com, is a simple, low-cost 'All-In-One' Cloud- based Business application platform. The integrated suite of applications has been designed to remove the necessity of investing in on-site back office administration and control systems, thereby allowing firms to concentrate on delivering their core, value adding services to their customers. Delivering the solution via the Cloud enables the management and staff to share information and manage their operations regardless of location, thereby increasing their efficiency, responsiveness and competitiveness whilst minimising their investment in operational overhead. Kpi.com delivers a comprehensive, integrated, business support infrastructure: Customer Relationship Management, Project Management, HR, Payroll, e-Commerce, Basic Accounting, MIS and Reporting. Kpi.com's cloud solution delivers all elements of the business are connected. Information, staff, sales and service, front office operations, back office functions, management and control are available immediately from any location and can be shared across the organisation. Muzaffar Karabaev is the Founder/CEO of the business and the designer of the software. His experience encompasses setting up technology platforms and running support operations. He has also worked in corporate finance and treasury functions and is the Co-Founder of COOConnect, the networking group for Chief Operating Officers in London.
2004 Establishment
Finnet Limited is engaged in offshore software development, web design, data analysis, and benchmarking to a handful of strategic digital media clients. Group provides Software, Application, Design, Consultancy and Data and Digital Media products and services to its customer base since 2005. Major customers include Mindshare Mena, DMGT (Daily Mail Group), Asset International Inc, AIP Corp, etc
2008 First product
Finnet started building its first product – SaaS apps, and Launched in 2010 Workforcetrack ERP beta product, which was later rebranded as kpi.com ERP, with the strap line – "Simply Manage Your Business" (Registered Trademark)
Over 400 customers
(So far company has over 400 active customers (about 300+ companies using kpi.com, total user base exceeds over 4,000 to date) and has core service only clients in Publishing and Digital, and web and mobile software sectors – mainly as off-shoring and subcontracting services


text:
It is said that Americans are weary of war. Maybe, or maybe they do not like Middle East wars. But I see no evidence that Americans are ready to chop the military down to size. As von Mises wrote "Contrary to popular belief, nations do not fight wars in order to make it possible for the arms factories to make money. Arms factories exist because nations fight wars." In other words, wars are driven by a demand for wars from nations and their governments.
Look at the stock price chart of Lockheed Martin since 2001. LMT is a prime military supplier and representative of the industry. The price goes from $30 to $140. The S & P 500 is up a mere 25% over the same period (like from $30 to $37.50).
When I see LMT significantly underperforming the stock market, then I'll entertain the idea that Americans may have turned against heavy armaments, a permanently huge military establishment, empire and wars.4:21 pm on December 2, 2013 Email Michael S. Rozeff


text:
If Toronto Maple Leafs head coach Randy Carlyle and general manager Dave Nonis play this right, they could find themselves having their cake and eating it, too. They might squeeze their way into a playoff spot while answering a couple of seasons' worth of evaluative mysteries and even if that means being first-round road-kill it would be hard to see it as being anything short of 'mission accomplished.'
This was the week that things changed. Joffrey Lupul returned and slipped snugly into the role of the most important personality in a Leafs uniform. Given three days between games, Carlyle laid it all on the line to goalies James Reimer and Ben Scrivens: one of you, please, take the job by the throat. Enough of the alternating nonsense, the coach said.
Then Wednesday, before a 4-2 win over the Tampa Bay Lightning, the Leafs said that Mike Komisarek agreed to waive his no-movement clause. Jake Gardiner was called up from the Toronto Marlies, Korbinian Holzer sent down, and suddenly it fit together. Dion Phaneuf back with Carl Gunnarsson after a steady diet of Mike Kostka and Holzer; Gardiner with John-Michael Liles and the surprisingly steady defence pairing of Mark Fraser and Cody Franson.
Liles and Gardiner seems a quizzical fit of too-similar players – Gardiner's suggestion post-game that it's a good pairing because "if one of us falls or something, the other's a great skater," offers some odd comfort – but in terms of components, for the first time this season there was a sense of whole to the Leafs' blueline.
When Komisarek finally screamed 'uncle!' it allowed the Leafs to send him to the AHL's Marlies after a 24-hour period, where it is expected he will be allowed to play his way into a compliance buy-out this summer. The defenceman, who hasn't been the same since he was a Montreal Canadien and injured his shoulder in a fight with Boston's Milan Lucic, still has one more year remaining on the five-year, $22.5-million (U.S.) contract he was given by Nonis's predecessor, Brian Burke. It's a not-too-subtle reminder in this season of evaluation that Burke's major shortcoming was giving out lousy contracts. Komisarek is still a $3.6-million cap-hit this season.
It was a necessary house-cleaning ahead of the NHL trade deadline. Komisarek is in some ways a tragic figure, at least in a sporting sense. He was thumped by Lucic in November of 2008, then targeted again in the playoffs. That same right shoulder would be dislocated again with the Leafs. The body failed, moreso than the spirit, and there is a sense that Komisarek never has regained the sense of comfort in his own skin.
Liles and Gardiner were conspicuously soft on the Lightning's first goal, a blueline shot by Radko Gudas, but Carlyle sure had a funny way of showing he would have no confidence in Gardiner: he gave him more minutes in the first period (8 minutes 14 seconds) than any other defenceman and through two periods his 13:47 tied him with Gunnarsson behind Phaneuf's 15:56.
"Very visible," is how Carlyle described Gardiner's game.
Gardiner played 19:20, and found the first-period flow to his liking. The best of his skills were on display when he scooted the length of the blueline to keep the puck in. The worst, according to Carlyle, was when he went to the wrong corner on a controlled breakout and "had a little 2-on-2 game" with Liles. That was visible, too.
Still, Gardiner said it was "like night and day," compared to his brief appearance with the Leafs earlier this season. "I was making better decisions, using my feet more," Gardiner said. "It was nice to get some bounces, too."
Now that Gardiner is here, the next parlour game for the chattering classes will be monitoring Carlyle's bedside manner with a player who many think can't adapt to his style. It will be a pleasant diversion from Carlyle vs. Mikhail Grabovski. But what if it all works out and Carlyle vs. Gardiner turns out to be as uneventful as Carlyle vs. Nazem Kadri. What then?Report Typo/Error
Follow us on Twitter: @Globe_Sports


text:
Tagged: 'NYPD'
Mets 101 Game Preview: Philadelphia Phillies at New York Mets
April 13th, 2015 at 10:07 AM
After splitting their first six games of the season on the road, the New York Mets (3-3) finally return home to kick off the Citi Field portion of their schedule. Their opponents for today's home opener at Citi Field are the Philadelphia Phillies (3-3), who many expect to be one...
Mets 101 Seven in Seven Series: Mike Piazza Timeline #3-Lifting New York's Spirits Following 9/11
January 19th, 2013 at 2:53 PM
Just in time for the New Year, Mets 101's Seven in Seven series returns as our gift to you. Each week, the Mets 101 staff will begin a countdown of topics related to the New York Mets (i.e. best third baseman, worst defeat, etc.). We will begin our countdowns with...