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There's a David vs. Goliath story unfolding in the land of bits, bytes and apps.
It involves a gaggle of students from San Diego State University's respected but modest science program. They squared off against some of the largest and richest schools in the country in the $10 million Qualcomm Tricorder XPRIZE, a competition to build a portable, wireless device that can diagnose and monitor a variety of diseases.
The competition drew more than 300 teams from around the world, including ones from MIT and UC San Diego. The field is down to 21 competitors, and SDSU, which is playing the role of David, is still standing. There's a good possibility that it will be chosen as one of 10 finalists in August.
The SDSU team has been working for about two years to develop a medical tricorder that can record five vital signs and diagnose 15 diseases. Its leader is Lambert Ninteman, a charismatic, forever-on-the-go business student. The 38-year-old cancer survivor wants his team's tricorder to fulfill its potential of helping people.
Ninteman recently spoke with U-T San Diego, and here is an edited version of that conversation:
Q: When I saw the level of competition that SDSU faces in this contest, I wondered, "Is Lambert Ninteman out of his mind?" Well, are you?
A: Absolutely. Totally out of my gourd. But since the Qualcomm Tricorder XPRIZE challenge was considered improbably difficult to impossible by many experts in the first place, what do your fellow competitors matter? We only really ever saw this in terms of challenging ourselves to meet the task. Who's bigger competition than yourself?
Q: A lot of teams have since fallen by the wayside, including the one from UC San Diego. Did you pause to gloat, or was it full steam ahead?
A: Uh, full steam ahead. I swear we didn't gloat. ... No one ever thought we'd get this far, and believe me, we're more surprised than everybody else. We're just a bunch of students, and we have badass technology.
Q: What is proving to be the most difficult part of this project?
A: Well, it's like trying to cram F-35 aircraft guts into a Prius. We have a 5-pound weight limit, so that really dictates a lot of our choices. There are already gold-standard methods of disease detection used in clinical labs around the world, and we're packing that functionality into a much smaller footprint. Some of the equipment used for these tests costs hundreds of thousands, if not millions, of dollars. We're trying to make it smaller and cheaper. You can see where it gets complicated. ...
Q: Can you identify a specific advance you've made?
A: I remember when we were trying to solve the vital signs piece. We had to continuously monitor five vitals for 72 hours. You can buy state-of-the- art sensors and equipment to do that, but we couldn't afford it. So we built software to integrate different, cheaper pieces, and make them work like a more expensive, integrated system.
Q: How did your own struggle to overcome cancer affect your thinking about mobile diagnostics?
A: In 1987, when I was 12, I was diagnosed with Hodgkin's lymphoma. The cancer metastasized through my whole neck and torso in a week. I didn't really understand what was going on at the time. But I remember how difficult it was for my family, the staff at Kaiser (Permanente), and for the doctors who were making really difficult choices for a kid. You just had to pray you got it right.
I got lucky; my doctors were good. I've been in remission for 25 years. Imagine if families could do blood work twice or three times a day, as opposed to once a month, or even longer? And imagine getting results back in hours or minutes, instead of days and weeks. This could change things for everyone, not just the sick. How much suffering could be prevented with good mobile diagnostics?
Q: You've talked a lot about teamwork, which can be messy. Emotions and egos are involved. Can you give me an example of a bad moment during this project, and what you learned from it?
A: Tell me about it! Emotions and egos really get heated when you have a lot of really smart people working together (and no one's getting paid!). We have a core team of a dozen that has been working steady on this for two years, and each semester we've had to recruit a fresh team from scratch to do a lot of the development, from project management to software programming. So, yeah, egos and emotions run high, and we've definitely had to work through our share of challenges.
Specifically, we had a critical submission coming up for XPRIZE back on May 15, which turned out to be smack in the middle of finals. So for the two weeks leading up, there was a lot of heated communications going around getting people to execute their pieces of the puzzle, because if we missed the deadline, we'd be out. A lot of people were really focused on grades, so we had to burn a lot of midnight oil to do double-duty. It was tough, and we did it. And we came up with some great internal processes as a result, like building template documents and cross-functionalizing team meetings, so we won't run into this problem next time finals roll around.
Q: You have smart people on your team — including your wife, Alexandra Swanland. Has there been a moment when you've had to gulp and set aside your own ideas and defer to her because she was right?
A: In so many stories, the ancient Greek heroes and leaders would go to the oracle at Delphi to seek guidance before making a big decision. I feel exactly the same way. Alexandra, my wife, is absolutely the oracle. Turns out her parents took her to Delphi when she was a month old, and she was born in Persia, to boot.
I think that all successful leaders need an oracle, someone to keep them in check, because you see everything perfectly in your mind, but life isn't perfectly ordered. You need people like Alexandra to give you perspective and keep you grounded. And you know, as much as I think I may have the right idea or a good solution to a problem, I have a greater duty to the team to succeed, and keep my eye on the prize. So I guess her job in Starfleet would be Astrometrics, the lab where they do stellar cartography and long-range navigation.
Q: What have you personally learned about problem-solving during this project?
A: I've learned that this takes grit. There have been huge sacrifices to make this happen, and no guarantees. Grit, imagination and a whole lot of faith in ourselves as a team. And as a team, we've had to face problems that far better qualified and funded teams have been stumped by, and we've just forged ahead regardless.
Q: You reference "Star Trek" a lot. Can you give me an example of how you solved a problem the way Captain Kirk and Spock would have done it?
A: How about Picard and Data, that's our generation!
So, it turns out that one of the most critical skills we've learned is diplomacy. You can't just roll up to a planet, er, I mean, an academic department/company, and open fire with demands of money and equipment. You have to open hailing frequencies, declare peaceful intentions and propose mutually beneficial cooperation. Then, beam up the new crew members and technology. Like Starfleet, our crew comes from all over the place. Everyone is really focused on the goal of winning the XPRIZE, so we're a lot like a starship. We're on this amazing journey of exploration, and we have no idea where this will go. I mean, we really are exploring new frontiers.
Q: Captain Kirk said, "A little suffering is good for the soul." Are you finding that to be true?
A: You know, this is perhaps the most profound part of this whole experience for me. I'm finding that not only is a little suffering good for the soul, it's essential to personal growth and evolution. You have to step outside of yourself and serve the moment, be an agent of change for something greater than just your own desires and agenda. People are starved for purpose and meaning these days, feeling that there has to be something more to life than just the pursuit of wealth and entertainment. We live on such an amazing planet, and we are so fortunate as a people, and we take so much for granted. A little suffering brings a whole lot of perspective and a lifetime of purpose.


text:
Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Inhibition of c-Fos/AP-1 Suppresses Passive Anti-Collagen Antibody-Induced Arthritis in Mice.
Mikami4, Masaaki, Aikawa5, Yukihiko, Hashiramoto3, Akira, Yamamoto5, Mari, Murao5, Hidetoshi, Chaki5, Hisaaki, Narita5, Hirokazu
Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan
Division of Rheumatology, Kobe University Graduate School of Health Sciences and Medicine/ The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan
Division of Rheumatology, Kobe University Graduate School of Health Sciences and Medicine/ The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan
Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan
Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan
Activator protein-1 (AP-1) directly regulates the genes that participate in rheumatoid arthritis (RA), including inflammatory cytokines and matrix metalloproteinases (MMPs). Anti-collagen antibody (Ab)-induced arthritis (CAIA) in mice is beneficial to study the inflammatory phase of arthritis without involving the priming phase of the immune response. Therefore, to elucidate the involvement of c-Fos/AP-1 in the development of arthritis, the levels of c-Fos/AP-1 in the hind paws were determined, and the effect of a novel c-Fos/AP-1 inhibitor T-5224 on CAIA was investigated.
CAIA was induced in BALB/c mice by i.p. injection of the mixture of anti-type II collagen (CII) Abs on day 0 and LPS on day 3. The levels of c-Fos/AP-1 in extracts from hind paws were determined using TransAM kit on day 0, 3, 4, 7, and 15. T-5224 was orally administered once daily. The effect was assessed by arthritis score, pathological examination, and serum biological analysis of IL-1b and MMP-3. Furthermore, effects of methotrexate (MTX) and leflunomide were also evaluated in the same procedure for the comparison.
c-Fos/AP-1 activity increased in the hind paws of mice after day 4 in coincidence with onset of the arthritis. The administration of T-5224 from day 5 efficiently suppressed the development of arthritis at 1 to 30 mg/kg, and the arthritis score on day 14 was inhibited by 81% at 30 mg/kg (ED50: 6.0 mg/kg). Histological changes such as cartilage degradation in the joints of hind paws of mice with T-5224 were also suppressed on day 14. In addition, the increases of IL-1b and MMP-3 levels in sera were reduced by T-5224, and the inhibition rates at 30 mg/kg were 97% and 89%, respectively. On the other hand, either MTX at 3 mg/kg or leflunomide at 30 mg/kg had no effects on passive CAIA.
The activation of c-Fos/AP-1 was observed in the arthritic lesion of mouse CAIA in which the priming phase of the immune response is skipped. Inhibition of c-Fos/AP-1 by T-5224 attenuated the arthritis through suppressing the inflammatory cytokine and matrix degrading MMP. On the other hand, immunosuppressive treatment with MTX and leflunomide did not show the inhibitory effects on CAIA. These data support a key role of c-Fos/AP-1 in the development of arthritis and joint destruction, and suggest that T-5224 with the novel mechanism of action is expected to exert anti-arthritic effects in the therapy of RA.
To cite this abstract, please use the following information:
Mikami, Masaaki, Aikawa, Yukihiko, Hashiramoto, Akira, Yamamoto, Mari, Murao, Hidetoshi, Chaki, Hisaaki, et al; Inhibition of c-Fos/AP-1 Suppresses Passive Anti-Collagen Antibody-Induced Arthritis in Mice. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :280
DOI: 10.1002/art.28049

subset: commoncrawl


text:
Dear ones, many of you live your lives like a boxer. But your fight is within, although many of you believe it is out there. When you wake in the morning is when the fighting begins. Your first punch is what you seem to be missing in your life, as though anyone can take away [Read More…]
The Boxer
December 22, 2010 by Leave a Comment


text:
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text:
Parking Behavior Changes Overnight
Fulton writes:
"Within a half-hour of the time paid parking was instituted in Downtown Ventura this morning, the parking universe had been turned upside down. The free offstreet parking lots, usually two-thirds empty in the morning, was mostly full. And the paid on-street parking spaces which are mostly occupied on a typical morning, were mostly vacant.
The paid parking portion of the downtown parking management program had gone into effect at 10 a.m., and it was already showing results. People who park all day downtown had moved into the lots and the upper levels of the parking garage. Spaces on the street were available for shoppers, diners, and others who were running short-term errands. In other words, only 30 minutes after we instituted the parking management program, it was working."
Thanks to Bill Fulton


text:
Fit assessment of anatomic plates for the distal medial tibia
Schmutz, Beat, Wullschleger, Martin E., Kim, Henry, Noser, Hansrudi, & Schutz, Michael A. (2008) Fit assessment of anatomic plates for the distal medial tibia. Journal of Orthopaedic Trauma, 22(4), pp. 258-263.
|Accepted Version (PDF 203kB)
Objectives: With the development and popularization of minimally invasive surgical methods and implants for fracture fixation, it is increasingly important that the available implants are precontoured to the specific anatomic location for which they are designed. The objective of this study was to develop a noninvasive method and criteria for quantifying the fit of a distal periarticular medial tibia plate and to test the method on a small set of tibia models.
Methods: The undersurface of the plate was extracted from a digital model of the plate. The surface of the plate was fitted to 21 computer tomography (CT)-based 3-dimensional (3-D) models of human tibiae. Four criteria were defined that constitute an anatomic plate fit and subsequently were applied for the quantitative fit assessment. The fitting of the plate undersurface to the bone was entirely conducted in a virtual environment.
Results: An anatomic fit of the plate was achieved for 4 of the models (19%). The individual categories generated fits of 62% (n = 13) for the proximal end; 43% (n = 9) for the proximal angle; 57% (n = 12) for the middle distance; and 57% (n = 12) for a distal fit.
Conclusions: Although for the 4 individual criteria plate fits of 43%-62% were achieved, a global/anatomic fit only occurred for 19% of the bone models. This outcome is likely a result of bone morphology variations, which exist in a random population sample combined with the effects of a nonoptimized plate shape. Recommendations for optimizing the fit of the plate are discussed.
Impact and interest:
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These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
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|ID Code:
|Item Type:
|Journal Article
|3D models, tibia, plate fit, periarticular plates, fracture fixation
|Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
|Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:
|Copyright 2008 Lippincott Williams & Wilkins
|Copyright Statement:
|This is the author-version of the work. The final, definitive version of this article has been published in the Journal, Journal of Orthopaedic Trauma 22(4):pp. 258-263, 2008 © < Lippincott, Williams & Wilkins.
|Deposited On:
|17 Apr 2008 00:00
|Last Modified:
|29 Feb 2012 13:48
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text:
Republished with Permission by Press Publications
First baseman Ryan Hotmer has always been known for his bat, a bat packed with more punch than an Olympic boxer.
Hotmer is now seeking a way to pack his punch with wood bats while playing for the summer collegiate Toledo Black Hawks in the Toledo Amateur Baseball Federation.
A 2010 Lake graduate, Hotmer smashed a team record 15 home runs during his three-year varsity career and finished his senior season with seven home runs and was a dominating presence on the mound, recording a 6-3 record with a 1.74 ERA in 52.1 innings pitched for the Flyers.
All of this success in high school prompted Hotmer to take his developing talents to Owens Community College this past season where he was one of the Ohio Community College Athletic Conference's (OCCAC) most prolific and feared sluggers.
An imposing figure on the mound and in the batter's box, Hotmer was an instrumental part of Owens' 25-13 season and helped lead the Express to a second place finish in OCCAC play, while earning all conference honors as a freshman and turning more heads than a cranium doctor.
"I worked very hard in fall ball and over the winter with our new coaching staff and I became a much better hitter," said Hotmer, who is studying physical therapy at Owens.
At 6-foot-1 and 225 pounds, Hotmer didn't waste any time launching his trademark, tape-measure blasts at the college level. The left-handed hitting slugger powered his way to third on the team with a .374 batting average. He ended the season with two home runs — good for second on the team — and drove in 17 runs in 30 games out of the third spot in the lineup for the Express while sending flustered opposing pitchers to the showers early.
In limited action on the mound, Hotmer (1-0), who bats from the left side but is a right-handed pitcher, proved to be one of first-year head coach Del Young's most reliable hurlers this season, firing 10.1 innings and allowing just two runs on five hits while striking out seven and walking four.
Young, who previously served as an assistant coach for six-plus seasons at Oakland University and Eastern Michigan University, was hired by Owens to take over the head coaching duties for longtime head coach Bob Shultz, who was forced to resign for unknown reasons after seven seasons at the helm of the program.
"I was recruited by the previous coaching staff as a pitcher," Hotmer said, "but when the new coaching staff took over they wanted to use me mainly at first base and a little on the mound. During our spring trip to Myrtle Beach, I got a chance to play first base and played well and just ran with it. I also pitched here and there when they needed me and I was pretty successful on the mound, as well."
With one season in the books, Hotmer, 19, is working on further developing his skills and competition this summer with the Black Hawks, which also play in the Tri-State Collegiate League, a summer wooden bat collegiate baseball league based out of Gahanna, Ohio.
"It's a difficult transition to summer ball because we use wooden bats, but I enjoy it. Summer ball is good and competitive baseball, but it's also a little more lax. It's a great way to work on my skills in a pressure free environment," Hotmer said.
The Black Hawks are coached by former Major League pitcher Ron Rightnowar. Rightnowar, 46, pitched parts of one season for the Milwaukee Brewers in 1995, posting a 2-1 record and compiling a 5.40 ERA in 34 relief appearances.
Rightnowar, a 1982 Whitmer graduate and Oregon resident, signed with the Detroit Tigers in 1986 as an amateur free agent after playing collegiately at Eastern Michigan University and spent four seasons with his hometown Toledo Mud Hens, going 10-10 with 13 saves and a 4.67 ERA, before being traded to the Brewers in 1993.
Hotmer understands the unique opportunity he has to play for a former Major Leaguer and has taken full advantage of his coach's vast knowledge of the game.
"Coach Rightnowar is a great guy and a great coach and he has really made all of us smarter baseball players," Hotmer said.
Hotmer says the biggest adjustment from high school to college has been the skill level of his fellow players, but Rightnowar has helped to ease the transition.
"In high school, you can rear back and throw it past guys or easily guess what pitch is coming at the plate, but in college it becomes a guessing game and a game full of strategy and thinking. Coach has done a great job helping us understand that we need more than pure abilities to be successful at this level.
"As a pitcher, you have to outsmart the hitters, change speeds, and have a game plan. The same can be said at the plate. You have to know what the opposing pitcher is throwing you, learn from your mistakes, and readily make adjustments. And I think I've been able to do that with his (Rightnowar's) help."
In 22 games for the Black Hawks, Hotmer is hitting .222 (12-for-53) and is among the league leaders in RBI (14) and doubles (4). In 8.1 innings pitched for the Hawks, Hotmer has yet to allow an earned run and has five strikeouts.


text:
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text: Hi all, I'm working on installing Compiz on BT3. However, I am having many, many issues. Right now I am trying to compile the Nvidia drivers on my system and according to some folks at the Nvidia forums and an Nvidia employee, the installer for the drivers will not work on a fat32 filesystem which is what filesystem I have BT3 installed to now. I have tried many times to simply copy BT3 to an ext3 and ext2 drive to no avail. So now the only thing I can think of is to do a full hard drive install onto an ext3 drive, install my drivers and then dir2lzm everything back up and go back to a live filesystem. My question: is that possible? Or what are the potential problems with this? Or anything I'm not thinking of? I'd hate to spend all the time doing this just to find out there's a fundamental reason it won't work and I was doomed from the get go. Thanks for any help.


text:
HOOVER, ALA. - Vanderbilt posted a 4-1 win over Georgia on Tuesday in the first round of the Southeastern Conference Tournament at Regions Park.
Georgia (31-25) took a 1-0 lead in the second inning off Drew VerHagen. Senior second baseman Levi Hyams led off with a double to extend his hitting streak to seven games. Junior catcher Brett DeLoach moved him to third with a groundout and senior Colby May notched an RBI with a groundout to second.
In the bottom of the second, catcher Spencer Navin reached on a leadoff walk. On ball four, the pitch struck home plate umpire A.J. Lostaglio in the arm. He had to leave the game, and 16 minutes later, the contest resumed with first base umpire Jack Cox moving behind the plate and Tony Walsh entering the game as the first base umpire. Navin made it third with two outs, and sophomore left-hander Alex Wood battled back to retire Vince Conde on a grounder back to the mound to keep Georgia in front 1-0.
Vanderbilt (30-25) broke through in the third with a two-out rally. After Wood struck out the first two hitters, Mike Yastrzemski was hit by a pitch, Anthony Gomez collected a hit and Conrad Gregor drew a walk to load the bases. Then, Navin lined a two-run single up the middle to give the Commodores a 2-1 advantage. Left fielder Jack Lupo followed and worked a full count before Wood struck him out to end the frame. Georgia missed a chance to tie the game in the fifth. Verdin led off with a base hit and collected his second stolen base of the night. He went to third on a Conor Welton groundout. With the corner infielders in, Powell hit a sharp grounder to first baseman Conrad Gregor, and he fired home to get Verdin, who was running on contact.
In the bottom of the fifth, Vanderbilt extended its lead to 3-1 on a run-scoring single by Gomez. Then with two outs and runners at the corners, Georgia lifted Wood in favor of right-hander Jay Swinford. Wood (7-3) had 92 pitches at that point and allowed three runs on five hits with two walks and five strikeouts. Swinford retired Lupo to keep it a two-run contest. With one on and one out in the sixth, Vanderbilt went to its bullpen, bringing in left-hander Brian Miller. VerHagen gave the Commodores 5 1/3 innings and allowed one run on five hits with no walks and one strikeout to improve to 6-2. Kemp made it 4-1 with a two-out RBI-single off senior Chase Hawkins in the sixth. Miller blanked the Bulldogs the rest of the way, allowing one hit with three strikeouts for his fifth save.
"I thought we did OK against their starter, VerHagen, but we had no answer for the sidearm guy, Miller," Georgia coach David Perno said. "Vanderbilt is playing well and got some big hits when it counted. We both had six hits, but they turned them in to four runs while we managed just one. We'll have to come out Wednesday and lean on Michael (Palazzone) to give us a good start and try to be more productive when we have chances to score. Alex (Wood) competed well tonight and gave us everything he had."
Georgia will face Auburn (30-27) in an elimination game tonight at 5:30 p.m. The game will be televised on CSS. The Tigers fell to second-ranked Florida 6-1 earlier in the day.


text:
Talking points
Our editors will be looking ahead today to these developing stories ...
Related topics
Thousands march against C.Y. Leung
More than 50,000 protesters are expected to march on the government headquarters to demand Chief Executive Leung Chun-ying's resignation over a perceived loss of credibility. The pro-democracy rally is just the tip of the iceberg, with possible moves to impeach him over illegal works at his home on The Peak. Days before the march, street clashes broke out between his supporters and dissenters, some of whom have taken to brandishing colonial flags.
Global bodies' leadership shuffle
New member countries assume the leadership of several major international groups. Ireland takes over the rotating European Union presidency, while the United Kingdom heads the Group of Eight (G8) for the year and Russia rises to the G20's helm. Pakistan chairs the United Nations Security Council, while five new non-permanent members - Argentina, Australia, Luxembourg, South Korea and Rwanda - take up their seats in the council.
Key appearance by Sudan leader
Sudan's president, Lieutenant General Omar al-Bashir, heads to the conflict-torn Blue Nile state for the launch of a dam, one of the country's biggest economic projects. He also makes a speech to the nation - his first major appearance since having throat surgery. The Blue Nile has been the site of deadly clashes between government troops and rebels aligned with South Sudan.
Banks get dose of Basel III
Banks in more than 20 countries, including China, begin implementing tighter capital requirements under the Basel III accord. The rule protects the financial system by having banks take on less risk. From 2013 to 2018, lenders are required to hold a reserve of 7 per cent of top-quality capital, which includes a 2.5 per cent buffer that can be used to withstand periods of financial stress.
Electricity tariff rises take effect
After the fireworks and lights of New Year's Day, Hongkongers wake up to heavier electricity bills this year as CLP Power's and Hongkong Electric's price rises come into effect. CLP will charge about 5.9 per cent more, while Hongkong Electric will charge 2.9 per cent more. Although the firms lowered their initial price-rise demand after a public outcry, CLP has warned there are more increases in store.
Changes to criminal law, pollution data
Seventy-four big cities on the mainland begin issuing hourly pollution monitoring data, in response to public complaints about choking pollution and grey skies. The data will cover sulphur dioxide, nitrogen dioxide, ozone, carbon monoxide and PM2.5 levels. At the same time, the newly amended Criminal Procedure Law takes effect, heightening protection of a suspect's rights and further streamlining the way civil disputes are handled. However, the amended law is criticised for effectively legalising secret detentions.
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text:
Pippa Middleton Breaks Out a Familiar Blue Blazer Following Her Work Day
Start Slideshow
Pippa Middleton Breaks Out a Familiar Blue Blazer Following Her Work Day
Pippa Middleton changed into a geometric dress and jacket for her walk home from work in London today. She wore the same blue blazer that she stepped out of the Goring Hotel in the day after her sister Kate's wedding to Prince William in April. Both Pippa and Kate are recognized for their fashion sense, and during Kate's recent trip to North America all eyes were on her many outfit choices. She went from casual jeans in Canada to a gorgeous Alexander McQueen gown for the BAFTA Brits to Watch dinner in LA and received rave reviews for her other wardrobe selections. While Kate is busy with royal life, Pippa's in the groove of her day-to-day routine, which also includes frequent workouts and dates with boyfriend Alex Loudon.


text:
Dear sir,
I have setup m0n0 Wall and to access the internet I
have the following rule.
LAN interface
Proto Source Port Destination Port
TCP/UDP LAN net * * *
This rule (above) works and allows me access to the
Now I want to make the LAN secure and only allow DNS,
HTTP and POP access from the LAN to the WAN. So I
delete the above rule and add the following rules.
Proto Source Port Destination Port
TCP/UDP LAN net 53 (DNS) * 53 (DNS)
TCP LAN net 80 (HTTP) * 80 (HTTP)
TCP LAN net 110 (POP3) * 110
If I only have these 3 rules then I cannot access the
internet (no Http access, no DNS, no POP access).
What is the mistake I am making? Can someone give me a
set of rules for simple access to the internet for a
small office please?
Best Regards,
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text:
You can practice IBM Cognos Analytics on the cloud from the following URL:
- https://cognosnext.bi.ibmcloud.com/bi, or
- you can go to http://analyticszone.com and click the Cognos Analytics link on that page.
You can login using your IBM ID.
There, you can test -for free- the latest version of:
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text:
cin still has the invalid variable inputed in it, and tryies to "put" it (
>> ) again and again into your
duoble a
cin.ignore() used with no arguments becomes
cin.ignore(1, EOF), as it has default values for its two paremters:
cin.ignore(256, '\n') which means "discard up to 256 characters, or until you find a new line character, whatever comes first".
cin.ignore() gets rid of 'q', but still has 34 to insert to the variable, which works!.
|But, I tried your code and it doesn't give me an ERROR message if I input 0 for "a". Other than that it works fine (except for the problem that Marcos was trying to fix also)
&& should be replaced with
|That is indeed shorter, although not sure if I totally understand the while statement.
while ( (std::cout << "Enter a value for a: "), !(cin >> a) || a == 0 )
(std::cout << "Enter a value for a: ") is evaluated, causing "Enter a value for a: " to be output and the return value of that expression is discarded. Then the other expression (
!(cin>>a) || a == 0)is evaluated and used to control the execution of the while loop.
!(cin >> a) evaluates to true when a double is not extracted from the input stream cin. If it evaluates to true, then the || operator short circuits execution and the body of the while is entered. If it evaluates to false, then the truth of the condition (and whether or not the loop's body is entered) is dependent on
a == 0.


text:
Olympia Madalinska Model
Scott KinghornnModel Male Edinburgh, Scotland, United Kingdom
My Website: Facebook Page
Mayhem # 2569054
About MeMy name is Scott Kinghorn I am an aspiring fitness model from Edinburgh, Scotland. I have great ambitions and I strive to develop my fitness modelling to the fullest. I am hard working, very professional and easy to work and get along with. I am on Model Mayhem to network with other models and work with some of the great photographers on here.
My modelling experience is quite vast. I have done numerous shoots based on a variety of styles such as fashion, fitness and artistic. My main focus point is within fitness modelling but I am open to any style of shoots. Last year (September 2012) I Won the largest UK Male Model Competition Mr Supernational.
Feel free to get in touch at any time! Thanks for visiting my page.
Facebook page for more info!
Have you worked with Scott Kinghornn? Add Credits for Scott Kinghornn! >>
Olympia Madalinska Model
BriansPhoto Photographer
Kuj Photographer
TAP Studio Photographer
imagents Photographer
Julia Darkler Model
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text:
Trial record 1 of 1 for: VTE 11-019
Previous Study | Return to List | Next Study
Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study) (APEX)
This study has been completed.
Portola Pharmaceuticals
Information provided by (Responsible Party):
Portola Pharmaceuticals
ClinicalTrials.gov Identifier:
First received: April 16, 2012
Last updated: June 21, 2016
Last verified: June 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to evaluate whether extended prophylaxis with oral betrixaban can prevent blood clots in the leg and lung that sometime occur in patients hospitalized for an acute medical illness and to compare these results with standard of care enoxaparin. The safety of betrixaban will also be studied.
|Venous Thromboembolism (VTE)
|Drug: Betrixaban Drug: Enoxaparin
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:
|(Apex) Multicenter, Randomized, Active-Controlled Efficacy And Safety Study Comparing Extended Duration Betrixaban With Standard Of Care Enoxaparin For The Prevention Of Venous Thromboembolism In Acute Medically Ill Patients
Further study details as provided by Portola Pharmaceuticals:
Primary Outcome Measures:
- Composite of VTE (DVT and/or PE) and VTE Death [ Time Frame: Occurrence of any of the events through the Day 35 visit ]
Secondary Outcome Measures:
- Number of patients with symptomatic VTE [ Time Frame: The occurrence through the Day 35 visit ]
|Study Start Date:
|March 2012
|Study Completion Date:
|January 2016
|Primary Completion Date:
|December 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Betrixaban
Drug: Betrixaban
Betrixaban 80 mg PO QD for 35 day + 7 days.
Enoxaparin Placebo: Once daily, 6-14 days
|Active Comparator: Enoxaparin
Drug: Enoxaparin
Enoxaparin 40 mg SC QD for 10 ± 4 days.
Betrixaban Placebo: once daily, 35 days
|Ages Eligible for Study:
|40 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- men and non-pregnant, non-breastfeeding women
- anticipated to be severely immobilized for at least 24 hours after randomization
hospitalized with one of the following
- congestive heart failure
- acute respiratory failure,
- acute infection without septic shock,
- acute rheumatic disorders
- acute ischemic stroke with lower extremity hemiparesis or hemi paralysis
Exclusion Criteria:
- a condition requiring prolonged anticoagulation or anti-platelets
- active bleeding or at high risk of bleeding
- contraindication to anticoagulant therapy
- general conditions in which subjects are not suitable to participate in the study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01583218
Hide Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01583218
Hide Study Locations
|United States, Alabama
|Birmingham, Alabama, United States, 35294
|United States, California
|Bakersfield, California, United States, 93308
|Fresno, California, United States, 93701
|La Mesa, California, United States, 91942
|Long Beach, California, United States, 90822
|Los Angeles, California, United States, 90073
|Modesto, California, United States, 95350
|San Diego, California, United States, 92120
|Stanford, California, United States, 94305
|Torrance, California, United States, 90509
|United States, Colorado
|Englewood, Colorado, United States, 80113
|United States, Florida
|Bay Pines, Florida, United States, 33744
|Clearwater, Florida, United States, 33756
|Jacksonville, Florida, United States, 32216
|Miami, Florida, United States, 33143
|Pensacola, Florida, United States, 32504
|Sarasota, Florida, United States, 34232
|Vero Beach, Florida, United States, 32960
|United States, Georgia
|Columbus, Georgia, United States, 31904
|Decatur, Georgia, United States, 30030
|United States, Illinois
|Chicago, Illinois, United States, 60611
|Oak Park, Illinois, United States, 60302
|United States, Indiana
|Carmel, Indiana, United States, 46032
|United States, Iowa
|Davenport, Iowa, United States, 52803
|Windsor Heights, Iowa, United States, 50324
|United States, Kansas
|Topeka, Kansas, United States, 66604
|United States, Kentucky
|Hazard, Kentucky, United States, 41701
|United States, Maryland
|Annapolis, Maryland, United States, 21401
|Baltimore, Maryland, United States, 21287
|United States, Michigan
|Detroit, Michigan, United States, 48202
|Grand Blanc, Michigan, United States, 48439
|Royal Oak, Michigan, United States, 48073
|Troy, Michigan, United States, 48085
|United States, Minnesota
|Duluth, Minnesota, United States, 55805
|United States, Mississippi
|Picayune, Mississippi, United States, 39466
|United States, Missouri
|Kansas, Missouri, United States, 64111
|Saint Louis, Missouri, United States, 63110
|United States, Montana
|Butte, Montana, United States, 59701
|United States, Nebraska
|Omaha, Nebraska, United States, 68131
|United States, Nevada
|Las Vegas, Nevada, United States, 89109
|Reno, Nevada, United States, 89502
|United States, New Jersey
|Atlantic City, New Jersey, United States, 08401
|Pomona, New Jersey, United States, 08240
|Somerville, New Jersey, United States, 08876
|Summit, New Jersey, United States, 07901
|United States, New York
|Buffalo, New York, United States, 14209
|Manhasset, New York, United States, 11030
|Staten Island, New York, United States, 10305
|Valhalla, New York, United States, 10595
|United States, North Carolina
|Durham, North Carolina, United States, 27710
|United States, Ohio
|Cincinnati, Ohio, United States, 45267
|Cleveland, Ohio, United States, 44106-5072
|Columbus, Ohio, United States, 43210
|United States, Pennsylvania
|Camp Hill, Pennsylvania, United States, 17011
|Philadelphia, Pennsylvania, United States, 19107
|United States, South Carolina
|Charleston, South Carolina, United States, 29425
|Orangeburg, South Carolina, United States, 29118
|United States, Texas
|Austin, Texas, United States, 78705
|Austin, Texas, United States, 78752
|Bellaire, Texas, United States, 77401
|Corsicana, Texas, United States, 75110
|Dallas, Texas, United States, 75216
|Fort Worth, Texas, United States, 76104
|Houston, Texas, United States, 77024
|Houston, Texas, United States, 77030
|McAllen, Texas, United States, 78501
|Mission, Texas, United States, 78572
|San Antonio, Texas, United States, 78205
|San Antonio, Texas, United States, 78258
|Victoria, Texas, United States, 77901
|United States, Vermont
|Colchester, Vermont, United States, 05401
|United States, Virginia
|Charlottesville, Virginia, United States, 22908
|Richmond, Virginia, United States, 23249
|United States, Washington
|Everett, Washington, United States, 98201
|United States, West Virginia
|Huntington, West Virginia, United States, 25701
|Buenos Aires, Argentina, 1280
|Ciudad Autónoma de Buenos Aires, Argentina, C1181ACH
|Cordoba, Argentina, 5000
|Coronel Suarez, Buenos Aires, Argentina, B7540DOL
|Corrientes, Argentina, W3400AMZ
|Córdoba, Argentina, 5000
|El Talar, Argentina, 1618
|Rosario, Santa Fe, Argentina, S2000DSV
|San Miguel de Tucumán, Argentina, T4000JCU
|Australia, Queensland
|Redcliffe, Queensland, Australia, 4020
|Australia, South Australia
|Bedford Park, South Australia, Australia, 5042
|Australia, Western Australia
|Nedlands, Western Australia, Australia, 6009
|Milton, Australia, Qld 4064
|Parkville, Australia, Vic 3050
|Randwick, Australia
|Richmond, Australia, Vic 3121
|Feldkirch, Austria, 6800
|Gratwein, Austria, 8112
|Graz, Austria, 8036
|Hartberg, Austria, 8230
|Linz, Austria, 4020
|Wien, Austria, 1100
|Wien, Austria, 1160
|Zams, Austria, 6511
|Bruxelles, Belgium, 1070
|Huy, Belgium, 4500
|Leper, Belgium, 8900
|Leuven, Belgium, 3000
|Yvoir, Belgium, 5530
|Belo Horizonte - MG, Brazil, 30150-221
|Botucatu, Brazil, 18618-970
|Brasilia/DF, Brazil, 70710-905
|Brasilia, Brazil, 70710
|Campinas, Sao Paulo, Brazil, 13059-740
|Campinas, Brazil, 13083-970
|Curitiba - PR, Brazil, 80030-001
|Porto Alegre/RS, Brazil, 90620-001
|Porto Alegre, Brazil, 90620-001
|Porto Alegre, Brazil, 90880-480
|Salvador/BA, Brazil, 40140-110
|Salvador/BA, Brazil, 41810-011
|Salvador, Brazil, 41810-011
|Sao Paulo, Brazil, 04012-909
|São José do Rio Preto- SP, Brazil, 15090-000
|São Paulo, Brazil, 01308-050
|SãO Paulo, Brazil, 01323-903
|Gabrovo, Bulgaria, 5300
|Pleven, Bulgaria, 5800
|Plovdiv, Bulgaria, 4002
|Sandanski, Bulgaria, 2800
|Sliven, Bulgaria, 8800
|Sofia, Bulgaria, 1202
|Sofia, Bulgaria, 1233
|Sofia, Bulgaria, 1407
|Sofia, Bulgaria, 1606
|Sofia, Bulgaria, 1784
|Sofia, Bulgaria
|Yambol, Bulgaria, 8600
|Canada, Alberta
|Edmonton, Alberta, Canada, T6K4B3
|Canada, Nova Scotia
|Halifax, Nova Scotia, Canada, B3H 3A7
|Canada, Ontario
|Hamilton, Ontario, Canada, L8L 2X2
|Hamilton, Ontario, Canada, L8N 4A6
|Kitchener, Ontario, Canada, N2M1B2
|Ottawa, Ontario, Canada, K1H 8L6
|Thunder Bay, Ontario, Canada, P7B 6R4
|Canada, Quebec
|Montreal, Quebec, Canada, H1T2M4
|Ontario, Canada, N8X 5A6
|Quebec, Canada, G1V 4G5
|La Serena, Chile, 170000
|Osorno, Chile
|Santiago, Chile, 7650568
|Santiago, Chile
|Temuco, Chile, 4781173
|Viña del Mar, Chile, 2570017
|Krapinske Toplice, Croatia, 49217
|Pula, Croatia, 52100
|Rijeka, Croatia, 51000
|Varazdin, Croatia, 42000
|Zadar, Croatia, 23000
|Zagreb, Croatia, 10000
|Zagreb, Croatia, 1000
|Czech Republic
|Caslav, Czech Republic, 286 01
|Chrudim, Czech Republic, 537 27
|Hradec Kralove, Czech Republic, 500 05
|Kladno, Czech Republic, 272 01
|Kromeriz, Czech Republic, 76701
|Kyjov, Czech Republic, 697 33
|Liberec, Czech Republic, 460 63
|Litomysl, Czech Republic, 570 14
|Olomouc, Czech Republic, 771 11
|Ostrava, Czech Republic, 703 84
|Plzen - Bory, Czech Republic, 305 99
|Praha 10, Czech Republic, 100 34
|Praha 1, Czech Republic, 110 00
|Praha 1, Czech Republic, 118 00
|Praha 5, Czech Republic, 150 06
|Praha, Czech Republic, 128 08
|Slany, Czech Republic, 274 01
|Strakonice, Czech Republic, 386 29
|Teplice, Czech Republic, 415 29
|Usti nad Labem, Czech Republic, 401 13
|Zlin, Czech Republic, 762 75
|Znojmo, Czech Republic, 669 02
|Aarhus N, Denmark, DK-8200
|Frederiksberg, Denmark, DK-2000
|Glostrup, Denmark, DK-2600
|Haderslev, Denmark, DK-6100
|Hellerup, Denmark, DK-2900
|Hillerod, Denmark, DK-3400
|Hvidovre, Denmark, DK-2650
|Kobenhavn NV, Denmark, DK-2400
|Silkeborg, Denmark, DK-8600
|Slagelse, Denmark, DK-4200
|Tallinn, Estonia, EE-10138
|Tallinn, Estonia, EE-13419
|Tartu, Estonia, EE-51014
|Helsinki, Finland, FI-00290
|Jyväskylä, Finland, FI-40620
|Kouvola, Finland, FI-45750
|Mikkeli, Finland, FI-50100
|Pori, Finland, FI-28500
|Tampere, Finland
|Turku, Finland, FI-20520
|Angers, France, 49100
|Arras, France, 62022
|Avignon, France, 84918
|Bois-Guillaume, France, 76230
|Bordeaux, France, 33075
|Brest, France, 29200
|Brest, France, 29609
|Cambrai, France, 59400
|Castelnau-le-Lez, France, 34170
|Clermont-Ferrand, France, 63003
|Colombes, France, 92700
|Dijon, France, 21079
|La Tronche, France, 38043
|Le Mans, France, 72037
|Lille, France, 59020
|Limoges, France, 87 042
|Montpellier, France, 34295
|Nantes, France, 44093
|Nimes, France, 30029 cedex 9
|Paris, France, 75004
|Paris, France, 75010
|Paris, France, 75908
|Pierre Benite, France, 69495
|Quimper, France, 29107
|Rennes, France, 35203
|Saint-Priest en Jarrez, France, 42055
|Tourcoing, France, 59200
|Valenciennes, France, 59300
|Vernon, France, 27207
|Tbilisi, Georgia, 0144
|Tbilisi, Georgia, 0159
|Tbilisi, Georgia, 0183
|Altenburg, Germany, 04600
|Bad Friedrichshall, Germany, 74173
|Berlin, Germany, 10787
|Bonn, Germany, 53115
|Dresden, Germany, 01067
|Dresden, Germany, 01307
|Essen, Germany, 45147
|Hamburg, Germany, 22559
|Heidelberg, Germany, 69120
|Karlbad, Germany, 76307
|Ludwigshafen, Germany, 67063
|Magdeburg, Germany, 39120
|Mainz, Germany, 55131
|Minden, Germany, 32429
|Möchengladbach, Germany, 41063
|Neuss, Germany, 41464
|Oberhausen, Germany, 46045
|Paderborn, Germany, 33098
|Rüsselsheim, Germany, 65428
|Troisdorf, Germany
|Weiden, Germany, 92637
|Wesel, Germany, 46483
|Wiesbaden, Germany, 65199
|Witten, Germany, 58455
|Baja, Hungary, 6500
|Balassagyarmat, Hungary, 2660
|Balatonfüred, Hungary, 8231
|Berettyóújfalu, Hungary, 4100
|Budapest,, Hungary, 1134
|Budapest, Hungary, 1097
|Budapest, Hungary, 1122
|Budapest, Hungary, 1125
|Budapest, Hungary, 1145
|Cegléd, Hungary, 2700
|Debrecen, Hungary, 4032
|Debrecen, Hungary, H-4012
|Eger, Hungary, 3300
|Gyula, Hungary, 5700
|Hódmezövásárhely, Hungary, 6800
|Kistarcsa, Hungary, 2143
|Mohács, Hungary, 7700
|Nagykanizsa, Hungary, 8800
|Szekszárd, Hungary, 7100
|Szolnok, Hungary, 5000
|Veszprém, Hungary, 8200
|Zalaegerszeg, Hungary, 8900
|Afula, Israel, 18101
|Ashkelon, Israel, 78278
|Haifa, Israel, 31048
|Haifa, Israel, 31096
|Jerusalem, Israel, 91120
|Kfar Saba, Israel, 44281
|Petach Tikva, Israel, 49100
|Safed, Israel, 13100
|Tel Aviv, Israel, 64239
|Zerifin, Israel, 70300
|Castelfranco Veneto, Treviso, Italy, 31033
|Bollate, Italy, 20021
|Frenze, Italy, 50134
|Genova, Italy, 16128
|Milano, Italy, 20085
|Milano, Italy, 20132
|Napoli, Italy, 80131
|Parma, Italy, 43100
|Pavia, Italy, 27100
|Piacenza, Italy, 29121
|Reggio Emilia, Italy, 42100
|Roma, Italy, 00168
|Varese, Italy, 21100
|Venezia, Italy, 30122
|Vittorio Veneto TV, Italy, 31029
|Daugavpils, Latvia, LV-5417
|Liepaja, Latvia, LV-3414
|Riga, Latvia, LV-1002
|Riga, Latvia, LV-1038
|Valmiera, Latvia, LV-4201
|Alytus, Lithuania, LT-62114
|Kaunas, Lithuania, LT-44320
|Kaunas, Lithuania, LT-45130
|Kaunas, Lithuania, LT-47144
|Klaipeda, Lithuania, LT-92231
|Klaipeda, Lithuania, LT-92288
|Siauliai, Lithuania, LT-76231
|Utena, Lithuania, 28151
|Vilnius, Lithuania, LT-04130
|Vilnius, Lithuania, LT-08411
|Vilnius, Lithuania, LT-10207
|Picayune, MS, Montserrat, 39466
|Arequipa, Peru, 05154
|Callao, Peru, CALLAO 2
|Lima, Peru, 01
|Lima, Peru, 18
|Lima, Peru, Lima 11
|Lima, Peru, LIMA 13
|Bialystok, Poland, 15-276
|Bydgoszcz, Poland, 85-168
|Bydgoszcz, Poland, 85-681
|Czeladz, Poland, 41-250
|Gdansk, Poland, 80-803
|Krakow, Poland, 31-121
|Krakow, Poland, 31-913
|Skierniewice, Poland, 96-100
|Tarnobrzeg, Poland, 39-400
|Warszawa, Poland, 01-138
|Warszawa, Poland, 02-097
|Wloclawek, Poland, 87-800
|Baia, Romania, 430031
|Bucharest, Romania, 020475
|Bucharest, Romania, 021659
|Bucharest, Romania, 022328
|Bucharest, Romania, 041915
|Cluj Napoca, Romania, 400006
|Cluj-Napoca, Romania, 40001
|Craiova, Romania, 200642
|Iasi, Romania, 700620
|Oradea, Romania, 410169
|Pitesti, Romania, 110884
|Targu Mures, Romania, 540136
|Timisoara, Romania, 300736
|Russian Federation
|Arkhangelsk, Russian Federation, 163045
|Barnaul, Russian Federation, 656024
|Barnaul, Russian Federation, 656045
|Belgorod, Russian Federation, 308007
|Chelyabinsk, Russian Federation, 454048
|Chelyabinsk, Russian Federation, 454091
|Ekaterinburg, Russian Federation, 620039
|Ekaterinburg, Russian Federation, 620219
|Irkutsk, Russian Federation, 664049
|Kaluga, Russian Federation, 428007
|Kazan, Russian Federation, 420012
|Kazan, Russian Federation, 420043
|Kemerovo, Russian Federation, 650002
|Kirov, Russian Federation, 610014
|Krasnodar, Russian Federation, 350086
|Lubertsy, Russian Federation, 140006
|Moscow, Russian Federation, 111539
|Moscow, Russian Federation, 117292
|Moscow, Russian Federation, 119881
|Moscow, Russian Federation, 119992
|Moscow, Russian Federation, 121552
|Moscow, Russian Federation, 127473
|Murmansk, Russian Federation, 183047
|Novosibirsk, Russian Federation, 630007
|Novosibirsk, Russian Federation, 630051
|Novosibirsk, Russian Federation, 630054
|Rostov-on-Don, Russian Federation, 344022
|Samara, Russian Federation, 443070
|Saratov, Russian Federation, 410028
|Saratov, Russian Federation, 410053
|Saratov, Russian Federation, 410054
|Smolensk, Russian Federation, 214018
|St. Petersburg, Russian Federation, 192242
|St. Petersburg, Russian Federation, 195067
|St. Petersburg, Russian Federation, 196247
|St. Petersburg, Russian Federation, 197022
|St. Petersburg, Russian Federation, 198205
|St. Petersburg, Russian Federation, 199106
|St.Petersburg, Russian Federation, 191025
|Tomsk, Russian Federation, 643012
|Yaroslavl, Russian Federation, 150003
|Yaroslavl, Russian Federation, 150030
|Belgrade, Serbia, 11000
|Kragujevac, Serbia, 34000
|Niska Banja, Serbia, 18205
|Nis, Serbia, 18000
|Pancevo, Serbia, 26000
|Sremska Kamenica, Serbia, 21204
|Singapore, Singapore, 119074
|Singapore, Singapore, 169608
|Singapore, Singapore, 169609
|Bratislava, Slovakia, 83305
|Nitra, Slovakia, 949 01
|Nitra, Slovakia, 94901
|South Africa
|Johannesburg, Gauteng, South Africa, 2021
|Johannesburg, Gauteng, South Africa, 2193
|Cape Town, Western Cape, South Africa, 7530
|Pretoria, South Africa, Gauteng 0084
|Worcester, South Africa, 6850
|Barcelona, Cataluña, Spain, 08003
|Barcelona, Cataluña, Spain, 08036
|L'Hospitalet de Llobregat, Cataluña, Spain, 08907
|Sabadell, Cataluña, Spain, 08208
|Sant Boi de Llobregat, Cataluña, Spain, '08830
|Tarragona, Cataluña, Spain, 43007
|Madrid, Communidad de, Spain, 28007
|Orihuela, Comunidad Valenciana, Spain, 03314
|Vigo, Galicia, Spain, 36204
|Madrid, Madrid, Communidad de, Spain, 28034
|Majadahonda, Madrid, Communidad de, Spain, 28222
|San Sebastián de los Reyes, Madrid, Communidad de, Spain, 28702
|Barcelona, Spain, 08023
|Barcelona, Spain, 08041
|Cartagena, Spain, 30202
|Girona, Spain, 17007
|Olot, Spain, 17800
|Pontevedra, Spain, 36001
|Salamanca, Spain, 37007
|Terrassa, Spain, 08221
|Donetsk, Ukraine, 83045
|Donetsk, Ukraine, 83114
|Ivano-Frankivsk, Ukraine, 76008
|Ivano-Frankivsk, Ukraine
|Kharkiv,, Ukraine, 61058
|Kharkiv, Ukraine, 61018
|Kharkiv, Ukraine, 61039
|Kharkiv, Ukraine, 61176
|Kherson, Ukraine, 73039
|Kirovograd, Ukraine, 25006
|Kyiv, Ukraine, 01023
|Kyiv, Ukraine, 02091
|Kyiv, Ukraine, 02660
|Kyiv, Ukraine, 03680
|Kyiv, Ukraine, 04060
|Lugansk, Ukraine, 91011
|Lutsk, Ukraine, 43024
|Lviv, Ukraine, 79010
|Odesa, Ukraine, 65009
|Odesa, Ukraine, 65014
|Odesa, Ukraine, 65025
|Rivne, Ukraine, 33001
|Simferopol, Ukraine, 95026
|Uzhgorod, Ukraine, 88000
|Vinnytsya, Ukraine, 21005
|Yevpatoriya, Ukraine, 97400
|Zaporizhzhya, Ukraine, 69000
|Zaporizhzhya, Ukraine, 69065
|United Kingdom
|London, United Kingdom, EC1M 6BQ
|London, United Kingdom, SE5 9RS
|London, United Kingdom, WC1E 6HX
|Manchester, United Kingdom, M23 9LT
|Newcastle Upon Tyne, United Kingdom, NE7 7DN
|Romford, United Kingdom, RM7 0AG
|Southall, United Kingdom, UB1 3HW
Sponsors and Collaborators
Portola Pharmaceuticals
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Portola Pharmaceuticals:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on July 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Gibson CM, Chi G, Halaby R, Korjian S, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Gold A, Bandman O, Harrington RA, Cohen AT; APEX Investigators. Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban). Circulation. 2017 Feb 14;135(7):648-655. doi: 10.1161/CIRCULATIONAHA.116.025427. Epub 2016 Nov 14.
Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM; APEX Investigators. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016 Aug 11;375(6):534-44. doi: 10.1056/NEJMoa1601747. Epub 2016 May 27.
Cohen AT, Harrington R, Goldhaber SZ, Hull R, Gibson CM, Hernandez AF, Kitt MM, Lorenz TJ. The design and rationale for the Acute Medically Ill Venous Thromboembolism Prevention with Extended Duration Betrixaban (APEX) study. Am Heart J. 2014 Mar;167(3):335-41. doi: 10.1016/j.ahj.2013.11.006. Epub 2013 Dec 10.
|Responsible Party:
|Portola Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01583218 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 16, 2012
|Last Updated:
|June 21, 2016
Keywords provided by Portola Pharmaceuticals:
Phase III
Additional relevant MeSH terms:
Venous Thromboembolism
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
ClinicalTrials.gov processed this record on July 21, 2017


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Joining with cities across the country following the shooting tragedy in Newtown, Conn., the Los Angeles City Council called Tuesday for tougher state and federal gun control laws, including a ban on the sale of assault weapons.
Three separate measures from Councilmen Bernard Parks, Paul Koretz and Dennis Zine that were approved on 12-0 votes called for city lobbyists to inform state and federal officials that the city is backing the tough sales provisions.
Mayor Antonio Villaraigosa last week called for a series of gun control measures including an order to the city's three pension systems to divest themselves of any investments made in gun and ammunition makers.


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WATER polo star Chloe Wilcox reckons Great Britain's defeat of illustrious world champions Spain has proven to UK Sport the wrong decision was made in respect of Olympic funding.
Reagill's Wilcox kept her composure to score a crucial late penalty as Great Britain's women staved off a Spanish comeback in the final quarter during their World League qualifying match.
Sealing a 9-7 victory at the Manchester Aquatics Centre, the result will go down as one of the finest results in the history of GB women's water polo.
The backdrop to the fixture was the uncertain future faced by the Great British team following UK Sport's £4.5m funding withdrawal, although Wilcox insists a point has been made.
"The result shows what a good team we are, perhaps we just needed a coach like Kostas Vamvakaris to organise us and give us confidence," said Wilcox.
"The last few months have been horrendous and there was certainly the added incentive to show UK Sport they have made the wrong decision regarding funding.
"I think it was the best result in the team's history and on the day we played brilliantly. We stuck to the tactics and concentrated.
"It was our last-ever home game and we just gave it everything. We had nothing to lose.
"We trained so hard in the build up to the match as we knew it was the only way we could show UK Sport how good a team we are and we deserve the funding they've cut."
It has been quite a few weeks for Wilcox who won gold with England at the Commonwealth Water Polo Championships in Aberdeen earlier this month.
And the 27-year-old firmly believes recent events, particularly the win against Spain, are the perfect preparation ahead of this summer's European Championships in Budapest.
"I'm back in Spain with my club team CN Mataro but I almost wanted to stay at home because we have this momentum going where everyone is really motivated ahead of the Europeans," she added.
"There was already such a buzz from the Commonwealths and the Spain game has given us much more confidence.
"We'll prepare for the Europeans the best we possibly can. It is likely to be the last thing we do together as the team is going to disband afterwards.
"We intend to give it everything in a bid to do something special."


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Last Man Super Bowl Game
Every year, a group of sports fans play a game called "Last Man."
The game was reportedly first played in 1989, and the idea is to be the last man in America to find out who won the Super Bowl.
This year, at least ten contestants committed on Twitter to avoid any knowledge of the outcome as long as they could, but they soon began dropping, because it's hard not to see stories about the Super Bowl online, on the news or to hear someone mention it.
CNBC's John Carney got knocked out this weekend. At last report, Brendan Loy, a father of 3 in Denver, is in the last remaining handful of players - he's avoiding email and most of his friends on Twitter.
It's an unofficial game with no prizes, just people trying to prove to themselves how long they can keep from finding out who won the biggest sporting event in America.


text:
Download PDF of Overview text here.
Education is a powerful driver of development and one of the strongest instruments for reducing poverty and improving health, gender equality, peace, and stability. Although there has been great progress in the last decade, some 121 million children are still out of primary and lower secondary school, and 250 million children cannot read or write although many have been to school.
Education has large, consistent returns in terms of income and counters widening inequality, but this potential is too often unrealized due to alarmingly low learning levels. Providing all children with a quality education that teaches them skills for work is critical to end poverty by 2030.
Last Updated: Mar 29, 2017


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explosive, brackish poop
heidiwhoric asks:
My daughter, has been pooping this explosive bowl movements for about a week now, and now there is this black tobabcco looking stuff in it, even now it is all clear, what is this...
Dear heidiwhoric,
Thanks for your question! BTW, what an unusual name! Heidi WHORIC? Bet you got teased a LOT in school!
Black, tobacco looking substances in your daughters poo could be caused by one of two things:
1. She is chewing tobacco, and is a swallower, not a spitter, or
2. She is bleeding internally from somewhere in her upper GI tract and the swallowed blood is showing up as black stool.
So, first thing is to ascertain if your daughter is chewing tobacco behind your back, as kids are doing in the bathroom at school these days. Next thing is to take her to an ACTUAL DOCTOR to discover if she is bleeding inside.
Thanks for asking Poonurse!
Please be advised that I am only a Poonurse. I am NOT a medical doctor. Any advice I give should be taken moderate skepticism. Please consult a REAL medical doctor if you feel you have a serious medical condition.
-- Poonurse
Poonurse is an RN with 25 years experience in labor and delivery. Her qualifications include seeing a lot of poop, and owning a computer. Also, she works in Michigan, which she calls the asshole of the universe, so that's another bit of credibility.
Got a question for her?
16 Comments on "explosive, brackish poop"
Nurse Poo:
It comes to mind that the afflicted individual may be going to a shushi bar and gobbling down seaweed wraps without sufficient mastication.
Your admirer,
WTF is SHUSHI?
Ummmmm ... shitty sushi? Or, maybe just plain old-fashioned sushi with an extra "h" in it.
OH!!!!! Well why didn't you shay sho??
I found Jesus! He was behind the sofa the whole time!
What are some reason why my poop would be black?
Maemitc, have you been taking Pepto Bismol? That would turn your shit black. So would some veggies, especially olives. But it could also be intestinal bleeding.
On the question to Poonurse, sounds like the kid has serious internal bleeding. Hope this person got help for her.
I found Jesus! He was behind the sofa the whole time!
Can you tell me about having explosive poop,pencil poop,blood in urine and poop, feeling terrible, stomach/butt aches. My husband has had this problem for over 2 years, had lots of things done, and meds no one really knows the answer other than he does have a enlarged prostate. Any advice?
Doing a proper differential diagnosis, the first thing you need to rule out is cancer, especially colon cancer and/or prostate cancer. Both of these are among the most common, yet most easily treated, types of cancer IF they are detected early! T, you say your husband has had "lots of things done," and I hope that includes regular, thorough medical exams. Sam says this "sounds like IBS," and although some of the symptoms you describe might be consistent with IBS, as one who has that problem himself, I believe your husband is dealing with other issues, too.
Sounds like he has problems with both the front door and the back. If you haven't already done so, I would get him an appointment with a first-rate proctologist and urologist before the sun goes down.
Investigating pencil poop "PP"---good info on here, anything through DIET cure "PP"...I'm going on one week of PP--and my butttt feels so tight that nothing can get through...and it hurts! Help a butt out.
Is it possible to rule out colon cancer without the colonoscopy? They are not fun. Can a biopsy be taken instead? Also, why am I bening sent to a gasteroenterologist instead of a proctologist? I am a 78 year old female. Thanks heaps.
and now there is this black tobabcco looking stuff in it, even now it is all clear, what is this..."
We call it shit.
That's a question for Motherload.
But I don't think so. A biopsy takes a sample of a mass. How would they know what to sample? You could have lesions or whatever anywhere in there. Plus, the risk of anesthesia should be saved for when you REALLY need it, if you ask me.
Good luck to you.
Too bad they won't let people just get really drunk before a siggy or colonoscopy.
newyorkperry, during a colonoscopy a tube with a camera attached to it is snaked into the colon and images are relayed onto a screen so that the doc can take note of any abnormal findings.
In the event that something suspicious is located, a biopsy of that area will be taken at that time. It would be inadvisable if not completely impossible for a doctor to start snipping out pieces of colon without the visual aid of the camera.
Since the tool used to take the biopsy is going to have to be stuck up your butt anyway, you might as well have the comfort in knowing the doctor isn't blindly hacking up your guts.
Gastroenterologists are medical doctors who specialize in the diagnosis and treatment of diseases of the digestive system, such as hepatitis, ulcerative colitis, Crohn's disease, and colon or rectal cancer.
Proctology is a field in medicine dealing with diseases and disorders of the rectum, anus, colon and pelvic floor. The word Proctology is derived from the Greek words Proktos, meaning anus or hindparts, and Logos meaning science or study.
Physicians specializing in this field of medicine are called proctologists. Most proctologists are surgeons by training.
So if you do happen to get diagnosed with something requiring surgical intervention, then the gastroenterologist would probably refer you to the proctologist at that point.
Always looking out for number two!
Always looking out for number two!
Today When I came back from walking my dog, I went to the bathroom, and I was surprised to see blood after I pooped! What is this, and will I need surgery? I have a fear of surgery!


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On the Swan River just behind the Waca the white horses are jumping up and down furiously. The Doctor is calling as it does every day sometime around noon.
You may be a bit fed up of hearing about the sea breeze known as "The Fremantle Doctor". But it matters. Even though you never see it, the wind can play a major role in any sporting event, especially in Perth, which is often cited as the second windiest city in the old Commonwealth.
The wind dictates so much that happens in a cricket match. Take the Ashes Test here four years ago. England were already struggling when Andrew Flintoff tossed the ball to Monty Panesar in Australia's second innings. Adam Gilchrist was flexing his muscles and he probably could not believe his eyes – or his luck – when Panesar was invited to bowl from the Prindiville Stand End at the Waca.
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The sea breeze was buffeting off the river. As Panesar contemplated his spell he must have recognised that it was gusting at several knots towards wide long on/deep midwicket if he was bowling to a left-handed batsman. Unfortunately for him Flintoff did not recognise the implications; Gilchrist did.
Twenty-four runs came from a Panesar over. Gilchrist had licence and he knew that he only had to make reasonable contact, get the ball airborne and a six was on the cards. In fact he hit three of them in one over on his way to a stunning 57-ball century. England were humiliated again.
Had Panesar been bowling at the other end Gilchrist would not have cleared the long-on boundary. He would not have been able to beat the wind. In fact he would not have tried because Gilchrist knows about the Waca; he played for Western Australia for most of his career.
So there is an extreme example: once the breeze is up it is not so easy to bowl into it. With the new ball James Anderson may try that Prindiville End since the wind could assist his away-swingers. Tim Bresnan, if selected – and the breeze may well influence England's selection plans – would certainly be busy from that end. And Graeme Swann will bowl his off-spinners from there. At least the breeze allows him to drift the ball away from right-handers so his reliable first slip, Paul Collingwood, will be on red alert.
Batsmen must be alert as well. They must expect some drift and swing. They should also adjust their running between the wickets. The Waca has long boundaries. If a fielder is hurtling the ball into the breeze, there is always one run for the throw. Conversely if he is throwing with the wind, even though he appears to be in the middle distance, watch out.
Now to the playing surface, which used to be unique. The Waca provided the fastest, bounciest pitch in the world in the 80s and 90s. When Jeff Dujon was keeping to Michael Holding he looked to be approximately 40 yards from the bat: so too did Rod Marsh for Jeff Thomson and Dennis Lillee.
The square has lost some of its pace recently and has even started to offer some turn for the spin bowler. But the pitch remains quicker than the majority around the world. It can still seduce pacemen, salivating at the extravagant bounce, into bowling too short for the sheer pleasure of watching the keeper soar in the air to take the ball. Especially if there is some swing it is important to bowl full because there is every chance that the nicks will carry in Perth.
For batsmen looking to survive, the ability to leave the ball is crucial. At the Waca it has always been possible to leave the ball on length as much as width. Usually the bounce is so reliable and high that many deliveries can be permitted to sail over the top of off-stump. Mark Taylor was especially adept at this and eventually the oohs and aahs from the slip cordon died down.
For those looking to score it is important to play the horizontal bat shots well. There will be the odd chance to drive as the bowlers seek to swing the ball. But when they drop their length, "you've got to be able to hook, pull and cut to score runs at the Waca", as Rod Marsh used to counsel to those disconcerted by the extra bounce.
Finally, the flies. They are bigger and more persistent in Western Australia than anywhere else in the country. When Don Bradman played his last Test innings at The Oval someone noted: "It's hard to score runs with tears in your eyes." Well, at the Waca it is also hard to score runs when swallowing flies. It helps bowlers, as well as batsmen, if they can go about their business with their mouths shut.


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I've reached that age where my friends are either engaged, newlyweds, expecting, or have small children. Those who fit into the last two categories on that list often ask me to find them web sites that offer child rearing tips or sites that are just for moms. Well, I certainly found a great one in Mom.me.
Mom.me is a community that is geared towards, you guessed it, Moms!
The site greets you with a pop-up collection of featured categories like Feeding Time, Mom Candy, Celeb Moms, Crazy Cute, and In the Loop. All the features offer something different for Moms. Feeding time provides recipes, Mom Candy provides a daily look at the staff's obsessions, and In the Loop follows news that would be interesting to parents.
If this looks like the site for you, then you want to click the Join Our Community link at the top of the page which will whisk you away to the registration form. Fill out the form with a username, create a password, and provide a working e-mail address then answer a few questions and click the check box to agree to the Terms of Service. All that's left then is to click the red Sign Up button and start participating in the community.
Check it out today!
Tags: babies, baby, celeb mom, children, mom news, mom on the go, moms, parenting, parenting news, products for moms, Recipes


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Hmm....I like being outdoors and trying new things, but also love relaxing and chilling out. I like good conversation, intelligence, ambition, and a good sense of humor. You would definitely need it around me.
I like people with big hearts always willing to give a helping hand. I like meeting new people and experiencing new things. I like to get people out of their comfort zones and getting to know more than just the bullshit.
Just laid back and looking to meet some interesting people
Life is short and trying to live it the best way possible, not being angry, facing any fears I may have, and making great memories.
I usually say things that are better left unsaid, talk to strangers, take a trip to anywhere without knowing my destination=(usually on my motorcycle). If I see a group of people gathering somewhere, I'm there. What the hell are they doing over there? Will I be jealous that I am not taking part?
I don't like the mundane conversations that people have with other people they meet for the first time. Anything besides the weather etc..
Movies...Big Lebowski, PIE, Memento, I heart huckabees, The Darlejing Project--I may have spelled that wrong, The Royal Tenenbaums, documentaries, Death at a funeral-(Not the US version), Election, Closer, News Room, Game of Thrones, Archer, .......
My friends
My family
My phone--It keeps track of my life
My sanity


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Former Black Sabbath Drummer Bev Bevan Voices Audiobook For Tony Iommi Autobiography
It's time for the holidays and you need stuff to add to your various wish lists. We're assuming that you've already asked for the paperback version of Black Sabbath guitarist Tony Iommi's book, 'Iron Man: My Journey Through Heaven & Hell,' as we suggested in our official Holiday Gift Guide, but another option is now available. The autobiography has been turned into an audiobook, read by former Black Sabbath / Electric Light Orchestra drummer Bev Bevan.


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Amber is done with the dishes and bends over to show her sexy ass. She undresses and strips naked while exploring her hairy pussy. She takes her flashlight and masturbates with it, making her pussy shine.
Masturbation, Toy Insertions, Tattoo, Lingerie, Brunettes, Curvaceous, Striptease
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Please click here to download it now.


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A 17-year-old girl from West Singhbhum, staying in a Ranchi lodge and preparing for competitive examinations, was found hanging in the shower on Tuesday afternoon.
Police suspect the incident, which took place at Ganguly Lodge in Lalpur close to Hotel Landmark, to be a case of suicide based on circumstantial evidence.
Although they are still not certain what prompted Priyanka Pradhans death wish, the incident followed a spat with her uncle over leaving the city and returning home.
According to preliminary investigations, around 2pm a roommate spotted Priyankas body hanging in one of the bathrooms; her dupatta being her noose.
Owner of the lodge, advocate Madhusudan Ganguly, was contacted who in turn informed police.
I received a call around 2.30pm and rushed to the lodge. Police have not recovered any suicide note. Hence, the reason behind the suicide has not been ascertained yet. The other girls could not offer clues either, Ganguly said.
Inspector of Lalpur circle A.K. Jha said they had registered a case of unnatural death and sent the body to Rajendra Institute of Medical Sciences for post-mortem. The report is yet to come.
The girl hails from Nua village in Goelkera police station area of West Singhbhum district. She was preparing for competitive examinations and taking physics and chemistry tuitions. We have informed her father A. Pradhan, Jha said.
He hinted that Priyanka was unhappy about staying in the city, away from her family and friends. Her uncle had come this morning and she wanted to go back with him, but he refused. She was found dead soon thereafter, he said.
The lodge in Lalpur where Priyanka was put up houses 20 other girl students.


text: David Hawkins wrote: > ... snip ... > > I've been adding casts to function calls where > appropriate to remove splint warnings. Since > I plan to run splint on code as I write and > test blocks of it, I'm quite happy with this > slight typing overhead. If you recommend an > alternate approach, I'm happy to listen. Please don't top-post. I strongly recommend against the casual use of casts, especially to shut up warnings. The result may be warning free, but can easily contain fatal errors. You are immediately overriding the compilers (and splint is a form of compiler) judgement with your own, and stating 'ignore this'. Unnecessary casts are most likely to be a sign of faulty initial thinking. -- Chuck F (cbfalconer at yahoo.com) (cbfalconer at worldnet.att.net) Available for consulting/temporary embedded and systems. <http://cbfalconer.home.att.net> USE worldnet address!


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Read and listen to our news on your iPhone, iPad or iPod Touch.
Business Web Hosting
Archaeologists blame two building companies for destroying part of ancient pyramid in the Lima district of San Martin de Porres (Peru). The pyramid El Paraiso, located near the river Chillon, is one of the oldest structures constructed in the Americas, made up of 12 pyramids and covering over 64 hectares.
Archaeologist Frederic Engel said in a report that El Paraiso could have held between 1500 and 3000 inhabitants and required over 100,000 tons of rock to construct, which was taken from the hills surrounding the structure, and was likely used for religious and ritual purposes. Evidence shows the culture living there was from the Late Pre-Ceramic Age (2000-3000 BCE). Despite its obvious importance to Peruvian culture, this pyramid was knocked down and later burned by several clandestine groups that entered the site recently.
Archaeologist Marco Guillén Hugo was in charge of the research and excavation of this site said he had reason to believe two private building companies, Compañía y Promotora Provelanz E.I.R.L and Alisol S.A.C Ambas, were behind the destruction. "This isn't the first time they have tried to take over this land," Guillén said, "They say they are the owners, even though this land is untouchable."
The Ministry of Culture has said that although the companies claim to own the land, it is actually under state control. The destruction of this pyramid, archeologists stated, was an irreparable loss for the culture and history of Peru.
Edited from Peru this Week (1 July 2013)
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Radical helos, V/STOL vehicles and UAVs are on US Army's shopping list
Complexities of future warfare lead to purchase of wide variety of unconventional aircraft.
AAI's version of the flying humvee will convert from ground to air mode allowing SOF teams to avoid ground and air threats as needed.
X-plane derivatives
SOF aviation experts are considering multiple configurations, including the tiltrotor technology of the Bell Boeing CV22 Osprey, in the quest to break through current rotorcraft limitations and increase their capabilities.
The tiltrotor's greater speed and distance add significantly to the SOF aircraft arsenal. X-model aircraft from Eurocopter, Piasecki and Sikorsky bring fresh ideas to newer rotorcraft capabilities.
Some design hopefuls today include technology from the Sikorsky X2 which will be rolled into the S97 Raider—a multiuse helicopter with a counter-rotating 8-bladed system, 6-seat cabin and a cruise speed exceeding 200 kts.
Other experimental designs for increased speed and noise reduction incorporate Piasecki's X49A—a highly modified UH60 with wings and modified tail antitorque/ thrust system allowing the aircraft to cruise at over 200 kts.
Eurocopter's X3 demonstrator promises increased speed and range with short wings and 2 propellers for forward thrust.
Additional DoD requirements for future vertical lift aircraft include optional piloted vehicles (OPVs) with beyond-line-of-sight (BLOS) capability for missions that too hazardous for manned operation.
Lockheed Martin's entry in the Transformer program proposes using a ducted articulating fan system to lift an armored humvee for air mobility.
Lockheed/Kaman are already using a specially configured K-Max to deliver supplies in Afghanistan with a remotely piloted unmanned helicopter to US Marines forward operating bases (FOBs) in remote or dangerous areas.
This greatly reduces exposure of US forces reducing the need for dangerous convoys and exposure to IEDs.
The 4 companies receiving "concept trade and analysis" contracts from the Army Aviation Missile Research and Engineering Center (AMRDEC) in Huntsville AL were Boeing, Bell/Boeing, Sikorsky and AVX—a 2-year-old company based in Texas started by former Bell Helicopter engineers.
If all goes to plan the Army hopes to field the biggest of the 4 categories of JMR with a payload the size of a Lockheed C130 in 2025. Follow-on JMR aircraft would be medium versions to replace the UH60 in 2027–28 for reconnaissance, medevac, combat search-and-rescue.
They could carry up to 24 passengers. Finally, the light and heavy versions of the JMR are expected to be fielded in 2030 and 2035, respectively.
Transformer and nanotech
Two vehicles hosted on DARPA's website as "feasible designs" for another direction in SOF vertical lift are flying armored humvees. AAI and Lockheed submitted designs for DARPA's Transformer—a "flying car" of sorts based on a humvee.
SOF teams have always been outfitted with the latest technology which does not always go through the long and laborious government development and procurement process which can take 10–15 years.
Nano air vehicles like DARPA'S Hummingbird UAV can provide unobtrusive aerial intelligence over a small area, greatly increasing SOF team situational awareness.
Rapid prototype and commercial off-the-shelf (COTS) procurements are possible with many SOF equipment ideas.
SOF teams would fly the vehicles in themselves and convert the flying vehicle into a road-ready humvee, complete the mission and exfiltrate from the operational area independently.
The Transformer designs include folding wings and ducted-fan-type lift systems which will allow the air/ground vehicle to avoid road obstructions and air threats as appropriate to accomplish the mission.
Specifications for the Transformer should allow the vehicle to travel 250 nm on land and air while carrying a 1000-lb payload.
DARPA expects the control system to be semiautonomous permitting a nonpilot to control the vehicle while transforming to VTOL flight without having a dedicated pilot for the vehicles.
As with the JMR program, design teams will conduct trade studies to "develop and mature propulsion systems, adaptable wing structures, advanced lightweight materials, the advanced flight control system, the air ground configuration designs, and energy distribution systems," according to DARPA's Waller, who is also Transformer program manager.
Additional DARPA aerial programs include nanotechnology that is already available. The Hummingbird UAV is capable of short-range surveillance and intelligence gathering.
This aerial device resembles an actual hummingbird and is the approximate size of the real thing which can be remotely controlled and flown through a building or over a fence and return without attracting too much attention.
As they say, knowledge is power and with this small nanoUAV, information is literally at one's fingertips.


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Anodized aluminium screws and washers for the visor on a Biltwell gringo S and Lane Splitter helmets. Great for adding a bit of contrast to your helmet or just to replace worn screws. Use blue Loctite when reinstalling the visor. It will help prevent the screw from backing out and flying off into the abyss. Also, make sure the indexing marks on the washers are lined up with the plastic backing plate on the helmet. Just rotate the collars until you feel them engage the backing plate.
All UK PURCHASES OF A TOTAL VALUE OF £50 OR MORE CAN ENJOY FREE SHIPPING.
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All UK orders that total less than £50 will be charged £4.92. We offer discounted international delivery because we absorb some of the delivery costs to all international destinations so you get the very best value. Please note that non EU customers do not pay VAT. Examples of international delivery costs can be found on our delivery information page. Please note that internatonal customers are repsonsible for any import duties that may be payable and to ensure that the products you have ordered can be imported into your country.
All UK customers receive a 1hr delivery window by text and email (if provided) for your convenience and improved first time delivery success.
All items that are in stock will be dispatched the same day for next day delivery in the UK. International deliveries will take longer. If an item isn't in stock you will receive an email to let you know when to expect to receive it.
Our prices are the most competitive around, and we regularly check our prices to keep it that way. That's why we will promise that should you find any of our products at a lower price anywhere else, we'll match that price AND give you a free thermal neck collar worth £14.99. So rest assured you can buy from us with confidence. If you have found this product cheaper elsewhere please email us. More information can be found in our T&Cs.


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2004 M3 Convertible in Portland, OR
I am selling my 2004 BMW M3 Convertible for an asking price of $56,000 or reasonable offer because my wife and I would like to purchase an investment home in Bend, Oregon.
Contact: Jamie Sumner on my cell at (503) 803-8474 if you are seriously interested. I will check this forum or you can email me away from the forum at firstname.lastname@example.com.
Features: Purchased new from http://www.kunibmw.com in April of 2004, 6700 miles, Titanium Silver exterior and Black leather interior, 6 speed manual transmission (not SMG), Xenons, Cold Weather package, Harmon Kardon system, 18" stock wheels.
If you would like to see high resolution pictures let me know because this service won't let me upload more than 122k.
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Your News Source for the Hilltop
Gardendale's Rachel Haynes crowned Miss Birmingham-Southern
BIRMINGHAM, Ala.-Rachel Haynes of Gardendale is
Miss Birmingham-Southern College 2002.
The freshman dance major was crowned following
talent and eveningwear competitions Saturday night, Dec. 1, in the
BSC Theatre. The 14 contestants also participated in swimsuit and
interview competitions earlier in the day.
Miss BSC 2001 Jennifer Bashaw, a senior psychology
major from Empire, crowned Haynes.
Haynes performed ballet en pointe to "Esmeralda"
to win the talent competition. Her platform is "Dying to be
Thin," which helps educate the public about eating disorders.
Sunday Vanderver, a junior political science major
from Remlap, was first runner-up to Miss BSC 2002. Her platform
was "Make A Wish Foundation," while her talent was a flute
solo, "The Carnival of Venice."
The other runner-ups included Kathryn Stewart
Stokes, a freshman pre-medicine major from Huntsville, second runner-up;
Michelle Downing, a sophomore computer science major from Dothan,
third runner-up; and Jamie Box, a junior biology-psychology major
from Winfield, fourth runner-up.
Resha Riggins Miles, Miss Alabama 1990 and winner
of the 1991 Miss America Interview Award, was the pageant host.
The Miss BSC Pageant is an official preliminary
competition for the Miss Alabama Pageant scheduled for next June.
Haynes will compete to become the 22nd Miss BSC since 1938 to also
be crowned Miss Alabama


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By Mason W. Canales
Killeen Daily Herald
NOLANVILLE – The City Council appointed Mayor Pro Tem Emma McCullough on Thursday to fulfill the remaining six months of the mayor's term.
The council decided unanimously that McCullough would take on the duties of mayor after former Mayor James Cox resigned last month.
McCullough will serve as mayor until the city can conduct a mayoral election in May. After the election, McCullough will retake her council seat.
McCullough's move to the mayoral post leaves one council seat vacant.
Under state law, the council doesn't have to fill the vacant seat, but it can appoint another member until an election if it chooses, said Jonathan Koury, assistant to City Attorney Alan Borjorquez.
It is unknown if the City Council will function with the empty seat or not.
Prior to the council naming McCullough mayor, several residents spoke about making decisions that are in the best interest of the city.
"Keep in mind what you do tonight is for the best interest of Nolanville," Stan Williamson, a former councilman, said from his seat in the audience.
Council members should keep their problems with each other out of the city's business, Williamson continued.
The City Council went into executive session for five minutes to consider its options about the empty mayor's seat before appointing McCullough.
Contact Mason W. Canales at firstname.lastname@example.com or (254) 501-7554.


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If you have kids in school who need a little help with their homework, many of Pima County's public libraries have a free homework help program.
They have onsite tutors available for all ages to help with math, science, social studies and writing. Some offer help in Spanish as well.
Click here to see a full schedule.