text:
London (CNSNews.com) - A central register of English gun owners has been delayed by technical difficulties, the government said Thursday, prompting criticism from both anti- and pro-gun groups.
The Firearms Certificate Holders Register will hold the names of every licensed gun owner in England and was part of gun legislation passed in 1997.
License records are currently held by local police forces, but the new database would have made all license records available to authorities on a national basis.
A spokeswoman with the Police Information Technology Organization, the government body responsible for the database, said initial bids by contractors seeking to build the database were too high.
In addition, technical problems in integrating local records forced the government to hold off on awarding the contract to build the database until spring 2003.
"We've had to take a fresh approach and look for better value for money," the spokeswoman said.
But gun-control advocates accused the government of dragging its feet on the creation of the central registry. Jill Marshall Andrews, chairwoman of the Gun Control Network, said she was shocked and disappointed by the delay.
"If the government really wanted to do this and the police really were behind it, it would have been done years ago," she said. "There is a lack of political will."
Marshall Andrews said the Gun Control Network wanted the database to be extended to guns themselves, in addition to gun owners.
"It's a big task but one we have to start," she said. "We need to try to find out what's happening to legal and illegal weapons."
Pro-shooting groups had differing views on the need for a database, but also expressed anger with the U.K. government.
Nigel Davenport, director of the Countryside Alliance's Campaign for Shooting, said he had no problem with a national registry.
"I don't see this as Big Brother breathing down our necks," he said. "People who shoot are responsible people who follow the law ... if this database helps police stop crime or helps to track guns that are stolen, that's a great thing."
Davenport said, however, that resources could be better used by focusing on illegal guns used by criminals.
"The 1997 law has done nothing to curb illegal gun use - if anything, it has gone the other way," he said. "It's a pity that we can't focus on fighting crime and illegal guns."
Joe Kelly, chairman of the Sportsman's Association, agreed that resources would be better used to crack down on illegal crime, but said his organization was opposed to the national database.
"It's a total waste of time and effort," he said. The whole country is awash with illegal guns, and the government is spending time and money putting in a database of legal guns. It doesn't make any sense at all."
But Conservative MP James Paice said he believed the database, once operational, would cut crime and criticized the government for failing to act quickly enough.
"One has to wonder just how much of a priority it is for them," Paice said. "This is yet another example of the government failing to deliver on promises."
The 1997 gun laws introduced compulsory rifle and shotgun registration at the local level and banned handguns. The laws were prompted by a 1996 school massacre in Dunblane, Scotland that killed 16 children and their teacher.
Send a Letter to the Editor about this article.


text:
TH!NK post
Climate Change: India's Solution- Part 2 of 2
Published 13th November 2010 - 0 comments - 1438 views -
The previous post on the issue talked about the Indian stance as a developing nation on the variety of issues that takes its attention away from strictly focusing on addressing the global concern of the climate change. The post also put forward the need of seeking a climate change solution due to the high damage potential to the population and the resources that inconsistent climate variability manifests. The two contrasts can be dealt effectively only if the policy makers juxtapose them as the priorities of the national policy framework.
Now Indian administration has started to make amendments in their development criteria and policy routing channels. They need to understand that for sustenance of a high growth rate, apart from increasing the living standards of a vast majority of people, it is now also crucial to reduce their vulnerability to the impacts of climate change.
Apart from affirmation from developed countries to direct the financial resources and the technology transfer to adapt and mitigate the climate change trouble, India needs to leverage its domestic landscape with a credible set of policies and initiatives.
National Action Plan on Climate Change (NAPCC)
NAPCC is one of the appreciable step taken by the Indian government to directly bring the climate change mitigation on the national development agenda. The action plan, stating a political statement that Indian per capita emission will never exceed that of developed nations, proposes "a directional shift in the development pathway" that promotes development objectives while also yielding co-benefits for addressing climate change effectively.
"In charting out a development pathway, which is ecologically sustainable, India has a wider spectrum of choices precisely because it is at an early stage of development. Our vision is to create a prosperous, but not wasteful society, an economy that is self-sustaining in terms of its ability to unleash the creative energies of our people and its mindful of our responsibilities to both present and future generations." -India's National Action Plan on Climate Change
The action plan which was released by the Prime Minister Dr. Manmohan Singh in 2008 focuses on harnessing renewable energy (rather than the stringent emission targets) and integrating it as a core element of the development process. It also recognizes the need of acting in multi fronts and putting appropriate institutional mechanisms to deal with the climate change challenge. There are eight national missions that form the core of the plan in integrating strategies and accelerated implementation.
The missions are:
National Solar Mission
- National Mission for Enhanced Energy Efficiency
- National Mission on Sustainable Habitat
- National Water Mission
- National Mission for Sustaining the Himalayan Ecosystem
- National Mission for a Green India
- National Mission for Sustainable Agriculture
- National Mission on Strategic Knowledge for Climate Change
The detailed focus of individual missions and their projected role in the development efforts can be seen here.
The implementation process which institutionalizes the missions to respective ministries also seeks the support of inter sectoral groups and ministries to overcome the issue with a collaborative and cooperative effort.
A Multi-Stakeholder Approach
Talking numbers, the energy sector is a major producer of CO2 in India. Our energy needs are mostly fed by coal (53%) which is abundant, locally available and cheap when compared to alternative fuels.
The source classification of energy in India seeks a serious attention. An analysis of the overall proportion of renewable and other alternate forms of energy shows that the proportion is not on the same trajectory as India's growth. This has led to a piteous emission to generation ratio of 0.82 (tCO2/MWhr) in the year 2008-2009. [source]
Source: Frost and Sullivan
Even though the per capita levels in India are less than the twentieth of that in the US but as per data published by Central Electricity Authority, CO2 emissions in power sector are continuously increasing at the annual rate of 4.43% in all parts of the country. Therefore the key stakeholders in mitigating the national emission levels are Ministry of Power and the Ministry of Renewable Energy among others.
Ministry of Power, which deals with the 60% of India's emissions will be directly affected by the 20-25% emission curbing plan that India currently has. The issues of inadequate generation capacity, high transmission and distribution (T & D) losses etc apart from the high emission to generation ratio seeks the reassessment of the Ministry's action plan. The ministry's objective of "Power to all by 2012" is of no use until they can vouch for its sustenance and maintain the ecological balance.
Ministry of Renewable Energy needs to design appropriate framework to harness the abundant alternative sources that the country has. India receives about 3000 hours of sunshine every day (equivalent to over 5000 trillion kWh. Also India has a potential of about 20 MW per sq. km. Even after being geographically blessed in terms of resources, India's investment in solar energy is very less compared to its growth-confrere China. The share of solar power in total generation is less than 0.1%. The government needs to put forward their sincere support in order to make private institutions pay attention and make a foray into the renewable energy sector. This support can come in the form of subsidies and feed-in tariff as seen in western nations.
As stated by the NAPCC, plan for reducing future emissions and their growth is leveraged by the country's developing status. The focus should be on renewable energy and energy efficiency to keep tab on carbon footprint.
It needs to integrate adaptation to the national development activities. The socio-economic policies, development projects and implementation strategies need to be revisited and reassessed to remove the vulnerabilities that the climate change uncertainty presents. Again I want to emphasize that the time has come when the country's growth level is gauged not only by the people's living standard but also by it's ability to sustain that.
About the author
Related posts
Popular posts
- TCKTCK: Got only 10 years to save ourselves!
- Denmark cries in Sea of Blood, 950 Whales and Dolphins KILLED…
- Micro pigs - the ultimate sweetheart energy saver
- If you want to see nude people click here
- Do we really care about our planet? Think twice before answering.
- Evolutions in the history of Environment Part 2
- Bunnies for fuels: not a good story to share in a grade school classroom

subset: commoncrawl


text:
New World Stages / Stage 4
340 West 50th Street
Between 8th and 9th Avenues
New York NY 10019
View on map
Add to My Event List
theAtrainplays, a daredevil theatre project in which playwrights, librettists, lyricists, composers, choreographers and directors create new work from scratch during the course of a single New York City subway ride. The performers, live band and designers then have 24 hours to put it all together, get off book, rehearse and perform the show.
Performers scheduled to appear will include Ashlie Atkinson (The Ritz), Lisa Barnes ("Rescue Me"), Stephanie D'Abruzzo, (Tony Award nominee, Avenue Q), Natalie Douglas (7-time MAC Award winner), Lawrence Feeney (My Super Ex-Girlfriend, "The Black Donnelly's"), Eric Michael Gillett (Kiss Me, Kate), Cady Huffman (Tony Award winner, The Producers), Michael Shawn Lewis (Phantom of the Opera), Orville Mendoza (Romeo and Juliet), Donovan Patton ("Blue's Clues"), Christine Pedi (Talk Radio), Michael Pemberton (The Farnsworth Invention), Darcie Siciliano (Red Dog Howls), Rene Ruiz (Toxic Audio) and Melanie Vaughan (Ring of Fire), among others to be announced.
The creative team includes writers Craig Pospisil, Barbara Hammond, Jonathan Marc Sherman, Erica Silberman and Jacquelyn Reingold; lyricist-composers Gaby Alter, Brian J. Nash, and Jeremy Schonfeld; director/choreographers Barry McNabb, Edie Cowan, Tony Parise, Joe Ricci/Tricia Brouk, and director David Hilder. Also involved are Alec Berlin (Musical Director), Andrea 'Spook' Testani (Production Supervisor), Andrew Donovan (original scenic design), and Rocky Noel (lighting and sound design). Producer: Lawrence Feeney, New World Stages and The Off-Broadway Theatre Alliance Press Agent: David Gersten
90 minutes, with no intermission
See this week's prices
May be inappropriate for 12 and under.Children under the age of 4 are not permitted in the theatre.
Monday - Wednesday: 1pm - 8pm (When there is a late performance, open until curtain.)Thursday: 10am - 8pm (When there is a late performance, open until curtain.) Friday: 1pm - 8pm (When there is a late performance, open until curtain.) Saturday: 10am - 8pm (When there is a late performance, open until curtain.)Sunday: 10am - 7pm (When there is a late performance, open until curtain.)Please Note: Advance sales for future performances end 30 minutes prior to the final curtain of the day.


text:
Find a Babysitter on Facebook
Who Will Watch the Kids at a Destination Wedding?
When a friend is getting married 1,500 miles away, families have to decide whether to bring the kids or leave them at home. Sometimes the choice is made for them but other times, parents must weigh the options. For my last destination wedding, my husband and I chose to bring the tots with us. While it was a fun family trip, it posed one major dilemma — who would watch the children while we go to the wedding? In my case, Facebook came to the rescue.
Some people are wary of social networking sites like Facebook and Twitter, but they can actually come in quite handy for mamas in need. After booking our flight, I logged onto my Facebook account and posted a status, "Does anyone have a babysitter in the Texas hill country?" Within minutes, I had three replies offering help and phone numbers. While none of my friends live in the area, they have friends who do and were able to put me in touch with their babysitters. In an hour, I landed a sweet and responsible young lady to watch my children. Just as expected, she showed up on time and ready to work. Other sites like Sittercity and Care Square provide references for caregivers all over the country, but I prefer a direct reference from a friend. And, it's free!


text:
This content has been marked as final. Show 2 replies
1. Re: ORACLE 11g express editionUdo Nov 20, 2012 8:56 AM (in response to 975183)Hi,
in contrast to 10g, there hasn't been a special client release for 11g XE. But can use the common 11g client...
2. Re: ORACLE 11g express editionorafad Nov 20, 2012 1:05 PM (in response to 975183)Simplest form of Client is the Instant client - e.g. Basic Lite and Sqlplus packages.
For Development needs, there's Oracle SQL Developer which is a great, free tool and client-less (jdbc client, actually), just unzip and go (specially the one with JDK included).


text:
Thanks for helping us sort this video!
Thanks for helping us associate the correct Pornstars to this video!
Help Us: Do these Pornstars appear in this video?
Pornstar Name:
"My current black boyfriend is 20year old Dennis Rodman look a like right down to the orange color hair and loves to fuck his 50 year old blonde white girl friend as well. God I love black men and big black cocks in me!'
Hey I look exactly like that hot blonde teen and I happen to be a 50 year old blonde white woman that still loves to fuck young black guys like my current 20 year old young black boyfriend and love when he cums in me as well!
Some errors occurred, please try again later


text:
Renting In The Private Sector
What to consider when renting from a private landlord and the information and money that may be required.
You can rent a property direct from a landlord or more usually through a letting agent.
You will usually be asked to provide a deposit of approximately one month's rent and a month's rent in advance. You may be eligible for help through our Rent Deposit Scheme.
An employer's reference, references from previous addresses and a guarantor may all be requested when submitting an application.
In addition you may be required to undergo a credit check. This will look at your financial history.
Tenancy Deposit Protection Scheme
All deposits taken by landlords and letting agents must be protected by a government-authorised tenancy deposit scheme. This means the money is stored in a third-party account, not the landlord's.
- Assured and Assured Shorthold Tenancies Guide
- File type: PDF
- File size: 0.67mb
- Student Accommodation Guide
- File type: PDF
- File size: 2.44mb
- Illegal eviction booklet
- File type: PDF
- File size: 0.33mb
- Notice that you must leave
- File type: PDF
- File size: 0.34mb


text:
Veolia Verkehr awarded Alstom Transport a contract for 36
regional Coradia Continental trains for the Bremen network that will be operated by
The trains will comprise three or five coaches, depending on
requirements, and will be designed and manufactured at the Alstom facility in Salzgitter, Germany.
The contract has an order value of about $208.5 million
(USD) in total, with the first trains going into commercial service in late
Estimates suggest that up to $24 million in uncollected fare could be recovered through a ticket-checking modernization initiative and other tactics.
The signs will be developed and finalized as part of a Mental Health Awareness Symposium to be hosted by Metra in September to coincide with National Suicide Awareness Month.
Some NJ TRANSIT trains have been canceled this week because engineers are choosing not to work under the terms of their contract amid the summer-long repair work at Penn Station.
Mayor Carlos Gimenez's $534 million proposal for rapid-bus routes would indefinitely defer the Metrorail expansion promised voters in 2002 during a referendum for a half-percent transportation tax.
Ruling called for an additional environmental study of the light rail line, despite the fact the project had already been studied and signed-off on by the feds.
Receive latest news and stories
The Car and truck fleet and leasing management magazine
managing 10-50 company vehicles
Executive vehicle management
managing public sector vehicles & equipment
The number 1 resource for vocational truck fleets
Serving school transportation professionals in the U.S. and Canada
Global Resource For Limousine and Bus Transportation


text:
Announcing a milestone. The mundane details of a daily routine. Post-doctor-appointment overshares. Facebook has become the place to share everything.
At the F8 Developer's Conference in September, Facebook announced how it will take our obsession for leaving a digital trail behind us to the next level. Enter Timeline: A visual chronicle of every status update, photo, comment, or "like" put on Facebook since the moment we first signed up. It will also give us the ability to add events in retrospect. I can't wait to upload my second grade ballet recital! Not.
Over 1.5 million users have already signed up for Timeline even though an official launch date has yet to be announced. As with past overhauls, Facebook is still sorting out programming bugs and legal troubles. Still, many speculate that Timeline will eventually become the only option for a Facebook profile.
Now please excuse me while I search for Saturday night (circa 2008) posts to delete.


text:
J.K. Rowling's Premiere Beauty: Magic or Medicine?
MakenzieR on 14 Jul 2011 at 9:00am
As fans question what J.K. Rowling will do next for their beloved Harry Potter characters, the media has shifted cameras from now out-of-HP-work actors to the woman who could continue the enterprise.
She was glowing and glamorous at the London premiere last week, but was it all pride and primping? It's tough to recall what she looked like pre-Hollywood highlights. But it's hard not to notice a more even complexion, sans freckles; tight skin, and little eye baggage.
So what do you think? Has Rowling seen the Wizard of Scalpels? Or maybe just the the Injection Fairy and Laser Lord?
Early interviews
Order of the Phoenix; Deathly Hallows Part 2 premieres, respectively
More photos from In Your Face
Photo credit: '98: entertainment.stv.tv; '99: luckreez.com; '07: NYDailyNews.com; '11: wishingforchanel.blogspot.com


text:
Dear Saints:
This has been a powerful week in my personal life.
On October 6th, we observed the 30th anniversary of the Universal Fellowship of Metropolitan Community Churches.
I've replayed the events of the past 30 years over and over in my mind. What a jumble of emotions and thoughts and feelings! I've felt a deep sense of spiritual peace. I've felt a healthy sense of accomplishment. I've recalled the lives we've touched and helped. I've thought about the ministries we've reclaimed and -- literally! -- the lives we've helped to save.
More than anything today, I am feeling joy at God's blessing upon the Universal Fellowship. Yes, out of my own meditation this week, I'm feeling a keen sense of joy at what God has accomplished through us over these past 30 years:
-- By our faithfulness, we've caused the debate over gay spirituality to be raised in every denomination and sect of Christianity. We've helped put the debate on the table and taken a bold stand for social and spiritual justice for all God's people.In my private time this week, God has deeply impressed these powerful words -- this powerful promise -- from Isaiah 61:7:
"Instead of your shame, you shall have double honor,
This month we launch a 10-month 30th Anniversary Celebration of the Universal Fellowship "A Jubilee of Joy!" which will culminate with the UFMCC General Conference and World Jubilee in Los Angeles July 11-18, 1999. I want to invite you to join us for this joyful celebration, including the dedication of the UFMCC World Center in West Hollywood.
The first sermon I preached at the very first MCC service in 1968 was entitled, "Be True To You." And, you know, I believe we've lived that message. Together, we've stood true to our calling. We've not wavered in the face of threats of attacks. We've not watered down our message to gain approval or acceptance. We held fast to our prophetic voice.
There's one other thought -- one final thought -- I'd like to share with you today...
I am absolutely, totally convinced that UFMCC's best days of service, ministry and growth are yet ahead of us. Everything I have learned from 30 years of ministry in the GLBT communities causes me to feel this. We've really just begun. I know this by the growing number of letters I receive from hurting, lonely people. I know this from the numbers of people still finding rejection and pain in other churches. I know this by the tidal wave of response we're receiving through the Internet, from websites and by e-mail. I know this by the number of people who stop me on the street to talk with me in every city I visit. I know this by the number of countries that have no affirming GLBT spiritual presence. I know this by the unfinished work yet to be done on behalf of social and spiritual justice for all people.
Saints, our best days of service and ministry are yet ahead of us!
So I invite you this week to set aside some time to thank God for the blessings which have been poured out upon the Universal Fellowship... to offer praises for lives healed and saved and restored through our churches ñ and then to look boldly to the future, believing that UFMCC's best days are yet to come.
This, indeed, makes for A Jubilee of Joy!
In Christ,
Don't Be Afraid Anymore : The Story of Reverend Troy Perry and the Metropolitan Community Churchesby Rev. Troy D. Perry
by Troy D. Perry
Lord Is My Shepherd and He Knows I'm Gay : The Autobiography of the Reverend Troy D. Perry
Lord Is My Shepherd and He Knows I'm Gay : The Autobiography of the Reverend Troy D. Perry
UFMCC Communications Department
E-mail: firstname.lastname@example.com


text: St. David's is a warm and welcoming congregation in Peters Township. We are an Episcopal parish where worship, service, and the nurturing of our children are at the heart of who we are and what we do. Our members come from many different backgrounds and perspectives and are united by our common worship, by our love, and by our regard for one another. We worship and celebrate the Holy Eucharist (Rite II) every Sunday at 10:00 a.m. Visitors and newcomers are always welcome. We look forward to worshiping with you soon.


text:
Law firm Bartier Perry has leased two floors in the 77 Castlereagh Street tower over Westfield Sydney.
Westfield Asset's general manager, Stewart White, said Bartier Perry was the latest high-quality tenant of the Westfield Sydney office precinct.
The precinct, with over 75,000 square metres of space, includes the new 85 Castlereagh Street and the reconstructed 100 Market Street, as well as the refurbished 77 Castlereagh Street.
All towers link to the Sky Lobby, four floors above ground, and the precinct is over 95 per cent leased.
Mr White said the leasing was "a reflection of the project's ability to meet the ever-increasing expectations of discerning tenants".
The chief executive of Bartier Perry, Luke Stevens, said 77 Castlereagh provided a "total package" with "highly efficient accommodation ... an unrivalled amenity and convenience for clients and staff, and a unique sense of vibrancy".
Bartier Perry has taken around 2500 square metres, with a linking stair between floors, on a 10-year lease. Details have not been disclosed. The deal would include gross rent of over $700 a square metre and an incentive.
Cadigal director Julian Grosvenor and Colliers director Cameron Williams are handling the leasing. Mr Grosvenor said tenants had responded well to the project and to the quality, the finish and the linkages to retail and restaurants offered by the Sky Lobby.
The Australian Financial Review


text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Chromatin is a highly structured nucleoprotein complex made of histone proteins and DNA that controls nearly all DNA-dependent processes. Chromatin plasticity is regulated by different associated proteins, post-translational modifications on histones (hPTMs) and DNA methylation, which act in a concerted manner to enforce a specific "chromatin landscape", with a regulatory effect on gene expression. Mass Spectrometry (MS) has emerged as a powerful analytical strategy to detect histone PTMs, revealing interplays between neighbouring PTMs and enabling screens for their readers in a comprehensive and quantitative fashion. Here we provide an overview of the recent achievements of state-of-the-art mass spectrometry-based proteomics for the detailed qualitative and quantitative characterization of histone post-translational modifications, histone variants, and global interactomes at specific chromatin regions. This synopsis emphasizes how the advances in high resolution MS, from "Bottom Up" to "Top Down" analysis, together with the uptake of quantitative proteomics methods by chromatin biologists, have made MS a well-established method in the epigenetics field, enabling the acquisition of original information, highly complementary to that offered by more conventional, antibody-based, assays.
Chromatin is a highly ordered nucleoprotein complex that both mediates the DNA compaction into the eukaryotic nucleus and regulates gene expression. At the structural level, the basic unit of chromatin is the nucleosome, consisting of 147bp DNA wound around an octamer core containing one histone H3–H4 tetramer and two histone H2A-H2B dimers [
Changes in the chromatin structure that do not involve the nucleotide sequence can translate into heritable adjustments of gene expression and thus be stored as an "epigenetic memory" of the cell [
Among the epigenetic maintainers listed, histone PTMs are largely recognized as key regulators of chromatin structure and function. hPTMs include acetylation, ubiquitination and sumoylation of Lysines; different methylation degrees of Arginines and Lysines; phosphorylation of Serines, Threonines and Tyrosines; ADP-ribosylation of Arginines, Glutamic and Aspartic acids; deimination (or citrullination) of Arginine; Proline isomerization [
The histone code hypothesis proposes that these modifications act either singly or in combination to control distinct downstream pathways or processes on chromatin, ultimately defining the functional status of the underlying DNA. The "letters" of this code are the modifications themselves, which are placed and removed by enzymes known as "writers" and "erasers", respectively. hPTMs exert their function on chromatin through two distinct mechanisms. In the first, higher order chromatin structure is altered via changes in inter-nucleosomal or histone-DNA interactions, thus controlling the accessibility of DNA-binding proteins such as transcription factors (
Antibodies specifically selected against hPTMs are traditionally used to study the language of histone modification through various assays. These include: immunofluorescence (IF) analyses of modifications at the single cell level, immunoblotting (WB) to profile PTMs in different samples and/or conditions, and chromatin immunoprecipitation (ChIP) that can be coupled to either PCR, DNA microarray (ChIP-on-chip) or deep sequencing (ChIP-Seq) for targeted or large-scale gene expression analysis. The last two methods allow the genome-wide mapping of modifications, with a resolution of a few nucleosomes [
Mass spectrometry (MS) has emerged as a promising complementary analytical strategy to identify known and novel PTMs on proteins, as well as for the relative quantitation and detection of synergies between them [
The "epigenomics" and "chromatomics" disciplines share a common goal in studying chromatin structure, composition and features: to gain a comprehensive view, from genome to proteome, of the epigenetic phenomena underlying the establishment and inheritance of specific expression patterns [
Before considering the different MS strategies applied to in-depth investigations of histones and non-histonic chromatin proteins, we offer here a concise synopsis of the basic principles of mass spectrometry, referring to specialized reviews for more detailed descriptions [
Essentially, all mass spectrometers measure the mass-to-charge ratio (m/z) of freely moving gas-phase ions in electric and/or magnetic fields. One of the most important developments in instrumentation has been the introduction of "soft-ionization" technology, which permits proteins and peptides to be analyzed by MS. Proteins and peptides are polar, nonvolatile species that require an ionization method to transfer them into the gas phase, without extensive degradation. Two techniques paved the way for the modern bench-top MS proteomics: matrix-assisted laser desorption ionization (MALDI) [
Liquid chromatography (LC) instruments are usually coupled "on-line" with the ESI source to achieve continuous or high throughput analysis. For instance, reverse phase high-pressure liquid chromatography (RP-HPLC) has been widely adopted in proteomics to resolve very complex peptide mixtures prior to MS analysis (LC-MS), due to its high resolution, efficiency, reproducibility, and mobile phase compatibility with ESI. A further development of this technology is nano-ESI [
Two levels of information are provided by LC-MS analysis of peptides and proteins. First, molecular weight and the elemental composition of the analyte can be extracted when the analyzer achieves sufficient mass resolution. In the second, information about the primary sequence can be obtained if the peptide of interest (precursor ion) is subjected to tandem mass spectrometry (MS/MS) analysis. MS/MS is therefore a key technique for protein or peptide sequencing and PTM analysis. Collision-induced dissociation (CID) [
This limitation has been addressed by the development of novel methods for ion-electron reactions to carry out peptide fragmentation: electron capture dissociation (ECD) and electron transfer dissociation (ETD) enable sequencing of larger peptides, providing an option to investigate combinatorial features of hPTMs [
The "Bottom Up" approach is highly popular in proteomics studies for investigations of protein PTMs [
Moreover, this derivatization labels unmodified and mono-methylated Lysines with a deuterated acetyl moiety (showing a delta mass of 45.0294 Da) but does not react with di-methyl, tri-methyl and acetyl Lysines, enabling the distinction between isobaric modification-bearing peptides. For example, peptide H3 (27–40) contains three Lysines, which can be differentially modified. In a case where two of these Lysines are mono-methylated, it is challenging to distinguish this species from an isobaric peptide containing a single di-methylation modification (
A limitation of the "Bottom Up" approach emerges when analyzing histone variants or combinations of histone modifications. In fact, the short tryptic and Arg-C-like peptides do not permit detection of simultaneously occurring, long-distance PTMs. Offline chromatography, to separate histone variants or differently modified versions of the same histone molecule prior to "Bottom Up" analysis, is one solution to this problem. For instance, the three mammalian variants of histone H3 (H3.1, H3.2 and H3.3) share the majority of peptides produced upon enzymatic digestion; however the intact proteins can be separated prior to digestion and LC-MS using tap-tag purifications and/or RP-HPLC [
The "Middle Down" approach is an optimal compromise between "Top Down" and "Bottom Up" strategies, when the mass spectrometer is hyphenated to online liquid chromatography. In "Middle Down" approach, large histone peptides (>2 kDa) are analyzed upon the enzymatic digestion of histones with endoproteinases that have specificities to less frequently-occurring amino acids within histone sequences, such as Glu-C or Asp-N. In fact, since mammalian H3 contains the first Glutamic acid at position 50, Glu-C at pH 8 produces an N-terminal peptide (1–50) of 6 kDa that contains the majority of PTMs decorating this histone, as well as being suitable for MS analysis and sequencing by either ETD or ECD MS/MS fragmentation. Similarly, Asp-N is useful for "Middle Down" analysis of histone H4, because it cleaves at the N-terminal side of Aspartic acid at position 24. Again, the resulting peptide (1–24) includes all modifications annotated at the H4 tail [
An inconvenience of the "Top Down" and "Middle Down" approaches is the need for specialized software to summarize the complex combinatorial networks existing among hPTMs. The main problems concern the complexity of the MS/MS spectra generated, either from intact histones or from large peptides, and the increased incidence of internal peptide sequence fragments that further complicate the sequence annotation and consequently the PTM site-specific attribution in the MS/MS spectra [
A number of bioinformatics tools have emerged to interpret the large amount of data generated by modern mass spectrometers. Of particular relevance to the analysis of the modifications that occur on histones are tools that enable identification of several different PTMs, often co-existing on the same peptide. Identification of PTM-bearing peptides in sequence databases, however, is more challenging than that of unmodified forms because the database search engine needs to take into account the diversity of modified forms that might exist. There are at present a number of computational methods available for the automated annotation of PTMs in peptides (
The computational methods used to identify PTMs fall into two categories [
In the second approach, which is unbiased, PTMs are identified through a "blind" database search. In the initial step, a basic database search is performed, excluding the specification of PTMs of interest, but often specifying recurring/standard modifications such as oxidized Methionine, for example. The specification of this relatively common modification avoids false-positive PTM assignments later on. Once a set of peptides is identified in an MS/MS-based proteomics experiment the idea is that, since the PTM leads to a mass increment or deficit of the modified peptide relative to the form without the modification present, all unassigned MS/MS spectra can be searched to find those which might match a post-translationally modified form. The software therefore inspects unassigned spectra, using information based on a list of known modifications such as delta-mass values and lists of predicted and observed peptide masses.
Computational methods that search for post-translational modifications are however associated with higher rates of false-positive identifications. The combinatorial issues linked with assigning the masses of included modifications can dramatically increase the number of peptide and protein candidates in the output. In this regard though, technological improvements that enable higher mass accuracy when generating the MS and/or MS/MS spectra have helped to address this issue [
Nevertheless some issues are still beyond the reach of current algorithms. The first is that some modifications may arise from
Various strategies have been developed in MS-based proteomics for accurate protein quantitation, from single proteins up to global proteome profiling. They can be grouped into four categories: chemical labeling, metabolic labeling, quantitation by the use of standard peptides and label-free. While the first three all rely on the use of differently isotope-encoded tags, the fourth implies the direct comparison among unlabeled proteomes. We refer to specialized reviews for an extensive description of these strategies for global protein analysis [
Chemical derivatization as a means to modify cleavable residues has been widely applied in epigenetic studies for their technical advantages, previously described [
Other chemical derivatization strategies, such as TMT and iTRAQ, have only been employed on chromatin for protein-level profiling, with no focus on PTM level changes [
A further limitation of SILAC is that it cannot be directly applied to clinical samples, as it relies on metabolic labeling of actively dividing cells. However, an interesting recent trend is the use of SILAC as an internal standard in the so-called "super-SILAC" approach [
The SILAC method has also been adapted for a range of other applications. In pulse experiments SILAC was used to measure the turnover of both hPTMs and histone variants: Zee
A combination of both standard- and heavy methyl- SILAC in pulse-chase experiments, carried out on synchronized cells, enabled Sweet
Label-free or ion intensity-based quantitation strategies have been applied in a few studies to profile differently modified, but isobaric histone isoforms, which have a special feature to present identical molecular weight/mass (isobars) but different PTMs configurations, so they are undistinguishable in full MS and can be hardly separated by standard LC. Since in MS/MS such isobaric species are distinguishable based on the positional selectivity of ion fragmentation, a relative quantitation is possible in a label-free MS/MS-based manner, using the relative ratios of their fragment ions. "Top Down" intact histone analysis was successfully used to quantify different modified forms of H3.2 and H4, in a label-free approach [
Lastly, synthetic, isotopically labeled peptides can be used as internal standards for both relative and absolute quantitation of histones and their PTMs in "spike in" assays. Briefly, isotope-encoded peptides are synthesized with the same sequence of the modified histone peptide of interest, derived from the endoproteinase digestion used in the study. Relative quantitation is obtained when a known concentration of the standard peptide is "spiked into" each histone sample from the panel under investigation, and the intensity of the each native modified peptide is compared with that of the standard. With the same approach the absolute quantitation of modified peptides can be also achieved, when a calibration curve of the ion intensity
In addition to post-translational modifications, histone variants contribute to the epigenetic regulation of gene expression [
Mammalian histone H3 has three major variants (H3.1, H3.2 and H3.3), in addition to a testis-specific variant (H3t) and a centromeric variant (CENP-A). The major variants are very similar in sequence composition. Histone H3.1 differs from H3.2 by a change in Cysteine 96 to Serine, while H3.3 differs from H3.1 by only 5 residues. However, they display differences in their expression, enrichment at specific chromatin domains, and in their post-translational modification signatures. Studies of the PTM patterns of H3 variants have been performed, profiting from all MS approaches described: "Bottom Up", "Top Down" and "Middle Down". "Bottom Up" analysis of mammalian,
Canonical human histone H2A is encoded by sixteen genes in a genomic cluster. Kelleher and co-workers identified and characterized twelve unique sequences by using intact mass and fragmentation spectra [
A combination of CID and ECD MS fragmentation at protein and peptide levels led to the characterization of several H2B variants and associated PTMs [
Histone H1 is commonly referred to as the linker histone. A single copy of this histone is proposed to bind near the entry/exit site of DNA on the nucleosome (the so called dyad), stabilizing the 30 nm fiber and thus regulating higher order chromatin structure and stability. Sequence divergence between histone H1 isoforms occurs mainly in the
Mass spectrometry contributes to the identification of a number of PTMs specifically enriched on distinct linker histones, such as methylation, phosphorylation, acetylation, ubiquitination, formylation and ADP ribosylation [
A better knowledge of chromatin composition can contribute to a more comprehensive view of its higher-order structure and function. Until now, no purification method has emerged as a "gold standard" for chromatin purification and characterization, due to the difficulty in enriching chromatin samples from specific functional regions at a purity and quantity sufficient for subsequent analysis. In spite of these limitations and thanks to recent achievements in MS-based proteomics in terms of sensitivity and accuracy of quantitative information, a number of studies have demonstrated the high potential of this technology to characterize the chromatin proteome, with a focus on the histone code readers associated with specific functional regions (
An analysis of changes in protein levels in response to the overexpression of the oncoprotein MYC was the first attempt to characterize chromatin-binding proteins. This was achieved using differential detergent/salt extraction and chemical isotopic labeling by ICAT, in combination with multi-dimensional chromatography and mass spectrometry [
One elegant methodology to study the proteomic composition of telomeric regions was developed by the Kingston group using the PICh (
All these methods provide a useful contribution to the knowledge of protein composition in large chromosomal regions or even intact chromosomes, but they are inadequate for gaining information on chromatin locus-specific composition.
Recently, a number of interactomics assays combining affinity-interaction mapping with SILAC-quantitative MS read-out have been developed for the comprehensive characterization of hPTM "readers". Vermeulen
A SILAC-based quantitative proteomics approach was employed to generate a differential profile of proteins associated with both euchromatin and heterochromatin, exploiting the different accessibility of these regions to MNase, as a consequence of the differential nucleosome packaging. Upon limited MNase treatment, the two fractions of chromatin were separated by centrifugation, based on the differential density of the nucleosomal stretches; SILAC was used to discriminate the proteins associated with these two functional chromatin regions [
DNA methylation also plays a pivotal role in mediating the epigenetic inheritance of specific expressions pattern on the genome, and the study of the interacting proteins is critical for a deep understanding of the molecular basis of its function. This has been achieved using immobilized oligonucleotides in combination with quantitative proteomics, in a setup very similar to protein-based pull down assays: DOC-1 (Deleted in Oral Cancer-1) and RBP-J (recombination signal binding protein for immunoglobulin kappa J region) were found to bind methylated CpG regions with this strategy [
Finally, given the increasing importance of RNA in the epigenetics field [
Mass spectrometry-based proteomics has emerged as a powerful analytical method for the analysis of histone proteins, their post-translational modifications and variants, as well as their associated "writers" and "readers". The method is therefore able to provide information that is in line with, and highly complementary to, other commonly used techniques, such as ChIP-Seq. In this review we have provided an overview of various MS-based proteomics approaches that enable novel insights into chromatin biology. In recent years, the advances in the dynamic range and sensitivity of MS instruments have allowed for improved detection of sub-stoichiometric histone PTMs. Furthermore, the novel chromatin interactomics' studies described in this review have led to the identification of regions specific modifications, variants and non-histonic associated proteins.
Detecting the combinatorial aspect of the histone code, however, remains a daunting task. The "Bottom Up" approach is efficient for amino acid sequencing and improved throughput for complex samples, however, it offers only a partial view of the complex cross-talks occurring among different hPTMs. In this respect, advances in "Middle Down" and "Top Down" approaches suggest that only a combination of the three MS approaches will provide the comprehensive solution to crack the histone code. At present however two major limitations limit the applicability of protein–centric approaches: first, the lack of straightforward "Middle Down" or "Top Down" analytical workflows, from sample preparation and protein separation, to MS detection and data processing, compatible with large-scale analyses; secondly, the bioinformatics tools available do not effectively handle the higher complexity of tandem mass spectra.
The global and quantitative profiling of hPTMs and the cognate interactomes by MS may have a strong impact in cancer epigenetics research. In fact, while for a long time much effort has been invested in identifying genetic mutations in cancer, in recent years the scientific community has progressively recognized that, in some cancers, epigenetic components may predominate over the genetic ones, with genetic and epigenetic determinants of cancer initiation and progression intricately entwined. In this light, the deep understanding of the epigenetic aberration in cancer is essential to recognize better why cancers arise (because the factors that could cause genetic damage might not be the same as those that could cause epigenetic damage) and why some cancers may respond better to certain types of therapies, as some types of therapies may be more efficient on epigenetically-damaged cancers. In this light, strategies based on the combination of high-resolution MS and quantitative proteomics for the analysis of chromatin, represent reliable, comprehensive and sensitive tools for the detection of changes in PTM abundances during the transition from a healthy condition to the tumor, offering an essential contribution to the understanding of epigenetic phenomena in cancer biology.
Tiziana Bonaldi's research is supported by grants from the Giovanni Armenise-Harvard Foundation Career Development Program, the Association of International Cancer Research, the Italian Association for Cancer Research, Cariplo Foundation, and the Italian Ministry of Health. Monica Soldi's work has been supported by FIRC fellowship.
The authors declare no conflict of interest.
Elution profile of H3 (27–40) modified peptide. (
Comparison of "peptide-centric"
Different biochemical approaches for the proteomic characterization of chromatin architecture. (
Software and search algorithms used to study hPTMs.
|Freely available
|Unbiased PTM search
|ProSightPTM 2.0
|Protein Prospector


text:
104 members
172 members
Dear Developer, i am using FrontlilneSMS 2.6.0, facing connectivity problem, getting error "failed to connect with -------- : connection.error.serial.portinuseexception" i have attahced required…Continue
Started this discussion. Last reply by chorongo salee Aug 7, 2015.
we have implement FrontlineSMS Afganistan for mental Health awareness, i want to post this on the case Study tab on the website of Frontline SMS.what is the process to Post a case study.???i am…Continue
Tags: health
Started this discussion. Last reply by Dodo Oct 31, 2014.
i am looking for the FrontlineSMS App for android , for that i find some intresting post on forum and, i have visited Google Play to donwload the app but there is no app for FrontllineSMS , if there…Continue
Started this discussion. Last reply by Dodo Nov 6, 2013.
i have to Develop a sms alerts systen for that i am using frontline SMS and HTTP tiggers.as for my knowladge Http tiggers feature is only for the just one SMS at a time but i want to send multipe sms…Continue
Started this discussion. Last reply by Florence Scialom Feb 15, 2012.
Dodo has not received any gifts yet
Posted on June 16, 2010 at 2:56am
Posted on June 10, 2010 at 9:04am
Posted on May 27, 2010 at 8:16am
Posted on April 9, 2010 at 6:59am — 3 Comments
© 2017 Created by FrontlineSMS Admin. Powered by


text:
This could be THE Weekend for the two of you to Explore, Rediscover, and Reconnect. Worldwide Marriage Encounter is a weekend getaway that helps married couples rediscover themselves as individuals and as a couple. The Weekend is God-centered and comes out of the roots of the Christian faith. Our Worldwide Marriage Encounter Weekends are Catholic focused, but we welcome couples of all faiths. Guided by a team of volunteer couples and a priest, each participant explores their relationship with each other, their spouse, and their family. WWME is faithful to the Roman Catholic Church's teaching that marriage is a covenant that exists between one man and one woman. Any reference to marriage or couple made by WWME is in this context.
The Weekend format helps couples communicate openly and honestly, without any group sharing, therapy or marriage counseling.
Great Marriages Don't Just Happen,
Couples Make Them!
All marriages need attention, effort and nurturing. Worldwide Marriage Encounter provides an opportunity for you to explore your relationship together and find ways to make it more fulfilling and stronger for a lifetime.
Give Yourselves a Weekend
At Worldwide Marriage Encounter, you get away from the distractions of everyday life and focus on each other. The team couples set an atmosphere for open and loving communication. They model the method, and share their own life experiences, making it easier for spouses to talk with each other.
Although your conversations are private between you and your spouse, seeing other couples striving for a better relationship makes it easier for you to communicate openly.


text:
Best Of :: People & Places
What's in a name? A lot, we learned, during last spring's brouhaha over Squaw Peak. But what do our state leaders do if the offending symbol is actually part of a state building?
Not much, apparently.
There they are -- swastikas -- carved right into the façade of the Arizona State Office Building in downtown Phoenix, home to the state's Department of Agriculture. As it turns out, the swastika -- then called a "whirling log" -- was a design element used in India, Tibet and Turkey long before Adolf Hitler hijacked it as the logo for his National Socialist Party -- and, ultimately, a universal symbol of hatred.
Ancient Native Americans used the "whirling log" in their artwork as well, including Arizona's Pima, Maricopa and Navajo, which is probably why it ended up as part of the Arizona State Office Building, erected in 1930.
But who thinks about whirling logs now? Not the Native Americans, who long ago signed a decree renouncing the use of the swastika on any artwork.
Guess it's harder to get out that sandblaster than it is to blast dissenters on a committee in charge of naming mountains.
With fresh white walls, great lighting and a dramatically high ceiling, this cavernous warehouse turned gallery space not only does justice to the intriguing art on display, but also to the downtown pretty things who turn up in droves on First Fridays to check out the work as well as each other. Any given month, monOrchid might also be hosting a hip local band or DJ, a fashion show, or even film screenings, giving the whole place a kind of dynamic vibe that you would imagine came out of Andy Warhol's Factory -- if only it had cropped up in the middle of the desert, not downtown Manhattan.
Aside from the experimental, no-budget "microcinema" events that have popped up in downtown art spaces, the best chance Valley cinema lovers have of seeing the edgiest indie films is at this jewel box of a theater, tucked in the shadow of Scottsdale Fashion Square. While some competition has cropped up recently, it's mostly from within the Harkins chain. (In particular, the Harkins Valley Art comes in a close second, with some decidedly non-mainstream features.) And as far as international titles are concerned, Camelview is frequently the only destination in the Valley to showcase the latest flicks from foreign shores.
Readers' Choice for Best Movie Theater: Harkins Ciné Capri
Craig's List is a free Internet bulletin board system where you can buy, sell and trade just about everything, as well as cruise personal ads, find a job, or enter into one of many community discussion forums. Created in San Francisco in 1995, Craig's List came to Phoenix in May 2003 and has steadily built up its listings. Although still relatively sparse when compared to those cities in which Craig's List is better established, it is an easy, anonymous, free way to post bulletin board listings. Users reply through the Craig's List's anonymous e-mail system to postings, and the poster can choose to make contact or not. There are no ads, and no charge for most ads (the exception being employers who pay a small fee to post job listings).
And sometimes it's funny, such as this ad from July: "Now hiring 6-10 smaller carny types to drive/ride in modified tiny' Volkswagen beetle for grand finale of traveling road show. Experience necessary: Ability to manipulate small handles under duress. Resistance to fire is a plus. Similar roadshows are now igniting finale performers. Ability to dodge potentially dangerous projectiles. Must get along with others and pack animals. Excellent communication skills. Benefits: Travel and experience the West Valley!"
There's also an active singles area, including a kinky "casual encounters" board and "missed connections" in which you can post a note to that handsome stranger you wish you had spoken to at the bar last weekend.
Noted baseball architects Ellerbe Beckett designed this beautiful facility that serves as home to the Milwaukee Brewers. Built in 1998, and originally planned to house two spring training teams, the Maryvale park is not Bank One Ballpark, and that's why we love it. Sure, you can't see regular-season major league play, but when a game is on in this no-frills park, you'll see why we love it. There's no fancy-schmancy country club seating, or waiters to bring you drinks. This is the kind of park where people come to watch baseball, not talk on their cell phones and network. The stadium has more than enough seats to handle the volume of patrons it gets, without feeling like its cavernous sisters in Peoria and Mesa. Its partial roof offers shade to a large part of the stands, which provides comfort without ruining the "outdoor" feel of watching the game. The grounds are impeccable, there is ample parking, and its bright blue seats are actually pretty comfortable for molded plastic. The concession areas are well-placed, offering a variety of standard fare at different locations so that not a lot of walking is necessary to get your hot dog and beer, and smaller vendors set up booths of more unique items at the end of the walkways, out of the way of traffic patterns. The lawn seats in the outfield are set up on a steep incline, allowing even those in the cheap seats a great view.
The British-born Binder threw the state Legislature into a tizzy last spring when she elected to take her long-planned vacation during the final days of a contentious debate on the budget. Binder already had balked at draconian cuts urged by Republican leadership, and her departure forced the Rs to compromise with Governor Janet Napolitano's proposal.
We love her for that. And we love her because she is one of the few legislators who isn't afraid to depart from party line and do what she believes is in the best interest of her constituents. Her independence has triggered absurd reactions from other Republican leaders like pinhead House majority leader Eddie Farnsworth, who refused to move any of Binder's bills to the House floor for a vote.
A fiscal conservative with a social conscience, Binder has been one of the few voices in the state pressing for reforms to stop the coerced underage polygamous marriages practiced by a fundamentalist Mormon cult in Colorado City. Her courage and high principles are matched by her polite demeanor that seems to have more weight with that classy British accent.
Readers' Choice: Janet Napolitano


text:
Results 1 - 4 of 4 matches
A perfect blend between the traditional china<BR/>cymbals and more western-orientated sounds.
This China's tone is dirty and fast.
Our product catalog varies by country due to manufacturer restrictions. If you change the Ship-To country, some or all of the items in your cart may not ship to the new destination.


text:
A sneak peek at an upcoming Wired article - images of the dorms in China's Foxconn factory. Interesting - supposedly open as a look, but is it really? And it is fascinating seeing how little you can live with, and yet what is considered necessary in this culture....
Where the Workers who Make Your Gadgets Sleep At Night
Current Status: Blessed (1)
Seeded on Sat Nov 6, 2010 7:36 AM
keyboard shortcuts: V vote up article J next comment K previous comment


text:
People to Watch in 2011
jennifer kinon
bobby c. martin jr.
Jennifer Kinon is a founding partner of OCD, an independent branding and design agency. She is also a faculty member of the School of Visual Arts MFA Design Program and president of AIGA/NY. Kinon most recently worked for Michael Bierut at Pentagram in New York. Her work with Pentagram won mulitple awards and is included in the permanent collection at the Museum of Sex. Previously, Kinon was design director of NYC's 2012 Olympic Bid and art director for Graphis Inc. She graduated from the University of Michigan, then earned an MFA from the School of Visual Arts.
Bobby C. Martin Jr. most recently worked as Senior Design Manager of Visual Communications at Nokia Design in London, where he oversaw communication and identity design across their global packaging range. Previously, he was design director of Jazz at Lincoln Center and worked at Ogilvy & Mather's Brand Innovation Group (BIG). Martin has been featured in Fast Company's Masters of Design 2010 and his work has won awards from major clubs and publications, as well as a Sappi Ideas that Matter Grant for his work for the Abyssinian Baptist Church of Harlem. He has served on the Board of AIGA/NY and taught at SVA. Martin holds an MFA from the School of Visual Arts and a BFA from Virginia Commonwealth University.
Where were you born, where do you live, did this effect your design style or sensibilities?
We were both born on the East Coast. Martin in Hampton VA, Kinon in Wayne NJ. And we both live in New York City now. We met at the School of Visual Arts MFA Design Program. The pace and opportunity of the city is ridiculous. It is always changing and we get to change and learn with it and when we're really lucky we get to push it along a little.
If you were not a designer, what would you do?
Martin would be an Illustrator.
Kinon would be an FBI agent.
young professional just starting out?
Find someone you admire and work with them.
Find someone you admire and work with them.
Design Hero?
Steve Heller (both)
Favorite Color?
Indigo (Martin)
Favorite Typeface?
Right now . . . Omnes Italic (Kinon) and Modula Ribbed (Martin)
Favorite App?
Bejeweled (Kinon) and Veggie Samurai (Martin)
Favorite TV Shows?
Anything on HBO (Martin) and Glee/Sons of Anarchy (Kinon)
Favorite Books?
A History of Graphic Design by Phil Meggs (Martin) and Sophie's World (Kinon)
Favorite Movies?
Pulp Fiction (Martin) and rom-coms (Kinon)
Favorite Music?
John Coltrane's A Love Supreme (Martin) and top 40 pop (Kinon)
Favorite Fine Artists?
Richmond Barthé (Martin) and Ed Ruscha / Bruno Munari (Kinon)
Favorite Gadget?
Xbox (Martin) and iPhone (Kinon)
Bookmarked Websites?
NYtimes.com, Gothamist, AIGA/NY (both)
Worst Habit?
Xbox (Martin) and iPhone (Kinon)
New Year's Resolution?
Get an office dog (both)


text:
Cisco Innovation Highlights Microsoft IgniteData Center
Today at Microsoft Ignite, Cisco continues to prove out our commitment to delivering the best data center and networking infrastructure solutions for the Microsoft portfolio. The proof comes in theRead More
Cisco Nexus 1000V Now Supports VMware vSphere 6.0Data Center
Following up on my blog post announcing our intent to support VMware vSphere 6.0 environments with Cisco Nexus 1000V, I am happy to announce that we now have the supported releaseRead More
Keeping Your Eyes on the Skies – A Partner's View on SQL Server and UCSData Center
A Guest Blog by Partner Rick Heiges of Scalability Experts: Rick is a SQL Server Microsoft MVP and Senior Solutions Architect. He primarily works with Enterprise customers on their DataRead More
Power of Open Choice in Hypervisor Virtual SwitchingData Center
Customers gain great value from server virtualization in the form of virtual machines (VM) and more recently Linux Containers /Dockers in data centers, clouds and branches. By some estimates, more than 60 %Read More
Get On With It! Your Cloud is WaitingEnterprise Networks
Sound familiar? We hear that term all the time. We hear it at home, we hear it at work, we keeping saying it to our elected officials. It's a termRead More
Cisco live Redux: Nexus 1000V InterCloud, Now Available, is a Hit to Enable Hybrid CloudData Center
If you live in the US, I hope you had a good 4th of July holiday last week. It's already been over a week since a very exciting Cisco live! IfRead More


text:
Used In
Crime and Punishment
Go to Book Vocabulary
Go to Word Detail
"Hush, don't laugh,
There are no more uses of "blaspheme" in the book.
Show samples from other sources
Did she
against the Prophet Muhammad?
Will the West stand up for its customs and mores, including freedom of speech, or will Muslims impose their way of life on the West? Ultimately, there is no compromise: Westerners will either retain their civilization, including the right to insult and
, or not.
Daniel Pipes
Go to more samples
Go to Book Vocabulary
. . . enhancing vocabulary while reading


text:
- 8. Compress Video for iPad
Of course you can use iTunes to transfer video from Mac to your new iPad. But if you wanna transfer video from Mac to your iPad wirelessly, this article will show you how to do it in detail.
1. iPad Home sharing:
But this method only allows you to play video in your iTunes library, that means you didn't actually sync the video from your Mac to the device. Once the Mac shut down, you then won't be able to access to your iTunes library, neither play the video. If this meets your demand, you can go to How to Set iPad Home Sharing and Share Music to iPad to set your home sharing on new iPad.
2. Transfer video to iPad wirelessly via iCoud?
You might wanna use iCloud to do the work. Yes, iCloud is believed to make people use iTunes less. (Does this mean that Apple would do more to enable customers to do things more simply?) This is a service released for iOS 5 users to transfer documents, contacts etc. between iOS devices, Macs running Mac OS X Lion or PCs running Windows Vista or Win 7. (5GB for free, up to 50GB on a yearly paid plan) With iCloud, you can do mobile backup, document and data sync, location awareness, and purchase management.
But iCloud is not temporarily available for transferring or backupping videos. So you can't use it.
3. Transfer video to iPad wirelessly via PhotoSync
If the two above didn't help, you can use third party applications to help. To be frank, there are numerous applications developed some geniuses to transfer videos for iOS devices. For example, iTransfer for Mac can transfer and convert videos from Mac to iOS and from iOS to Mac. And here, to transfer video to iPad from Mac wirelessly, PhotoSync wins a high reputation.
Download iTransfer here!
To sync and play video on your iPad, you'll first need to make sure the video is playable on the device – for iPad, you can only play video in MP4, MOV, M4V and some particular AVI. So if your files unfortunately are in AVI, WMV, MKV or other incompatible formats, you have to convert video to iPad video before the transfer.
While your video is compatible with the iDevice, connect your device to the same Internet work with your Mac, open PhotoSync on your new iPad, then select the target video and start to transfer the video from Mac to the iOS device. There's no need to enter IP-addresses and wait for the the transfer to finish. You can let the transfer run in the background and play games or whatever on the device at the same time.


text:
Selected Community Events
Patty's Plants Natural & Organic Garden Supplies 5th Annual Christmas Open House & Market
Nov 16, 2012 - Nov 18, 2012 Fri.-Sat: 8:30-5:30, Sun.8:30-3
819 E. High St. Milton WI 53563
Patty's Plants Natural and Organic Garden Supply's 5th Annual "Old Fashioned Christmas" Open House November 16,17,18
Featuring: Handcrafted Ornaments by Local Artists, Gifts for the Gardener Fresh Cut Christmas Trees, Greens, Wreaths, Roping, Swags, Poinsettias, Christmas Cactus, Amaryllis and much more!
Plus Special Sunday Event Nov. 18th from 10:00 am-2:00 pm 819 E. High St. Milton, WI 53563
Local Market Farmers, Artists, Crafters and Boutique Vendors in The Chapel Specialties Building with Patty's Plants
, Charming B's Coffee Shop. Indoor Market also in Small Wonders Learning Center (Across from Patty's & Charming B's)
Patty's will be serving samples of Windridge Herb Farm's Famous Pumpkin Dip & Homemade Apple Cider with Special Mulling Spices.
Patty Bailey


text:
Every good wish from us to you and yours at this time. We hope you will soon have all the reading material you want for your holiday because although our Digital Media catalog will be available online throughout the holidays (for those of you who receive digital devices as gifts!), our library doors will be closed as follows:
We close Thursday, December 22nd at 5 pm and re-open Tuesday December 27th at 8 am.
The Common Grounds Cafe at the back of the library will close December 22nd at 4 pm and re-open Tuesday, December 27th at 9 am.
At New Year's, we close Friday, December 30th at 5 pm. and re-open Tuesday, January 3rd at 8 am.
The on-campus cafeteria in the Commons building will be closed from December 19th to January 4th. January, 5, 6, and 9-13, it will be open reduced hours: 7:30 am. to 2 pm. except Fridays, when it will close even earlier at 1 pm. It will also be closed on Monday, January 16th, but resume its regular hours January 17th. Its regular hours are Monday-Thursday, 7:30 am-4 pm and Friday from 7:30 am-1 pm.
Permaneceremos cerrados a partir del 22 de diciembre para reanudar nuestras operaciones el martes 27 de diciembr. Horario para El Año Nuevo: El viernes 30 de diciembre cerraremos a las 5pm; para abrir de nuevo el martes 3 de enero.
[1] http://www.hcpl.net/users/barbara-m
[2] http://www.hcpl.net/category/locations/tomball


text:
STUDLEY-based Blue and White Rope Skippers (BWRS) will be appearing on A Question of Sport on BBC1 Wednesday, January 9 at 10.35pm.
BWRS representatives that took part were Tasmin and Rozina Jones, Bobby Thomas, and Sophie Trevis-Smith, who performed a small demonstration and turned the ropes as part of the Captain's Challenge.
Celebrities taking part in tonight's edition include Paralympic gold medallist Ellie Simmonds, former world superbike star James Toseland, footballer James Beattie and Winter Olympic skeleton champion Amy Williams, as well as presenter Sue Barker and team captains Phil Tufnell and Matt Dawson.
The programme will also be repeated this Friday, January 11 at 7.30pm.


text:
To print: Click here or select File and then Print from your browser's menu.
--------------------------------------------------------------------------- © 2011 - 2016 Bali Discovery Tours, All rights reserved. This message originated from http://www.balidiscovery.com/ Find it online at http://www.balidiscovery.com/messages/message.asp?Id=8898 ---------------------------------------------------------------------------
(12/9/2012) Indonesia's Minister of Health, Dr. Nafsiah Mboi, visited the newly opened BIMC Hospital at Nusa Dua, Bali on Tuesday, December 4, 2012.
As reported by The Bali Post, accompanied by a number of her staff, the Minister was greeted by the management team of the Hospital and taken on a tour of its modern medical facility.
The BIMC Hospital was established in Bali 14 years ago with its first clinic located near the Simpang Siur intersection in Kuta. Later, a new hospital facility was opened a short distance from the original clinic in Kuta
This year the BIMC opened a second state-of-the-art hospital within the Nusa Dua Complex at the southern tip of Bali.
After viewing the Nusa Dua hospital, Dr. Mboi said, "I am both impressed and proud the see the modern facilities and the dedication of the team at the BIMC."
Dr. Mboi, who is a pediatric specialist, spent time with BIMC's management discussing future health planning in Indonesia and the role of medical tourism. Adding, "I hope and am certain that the BIMC Hospital will play an important role in medical tourism in Indonesia, especially in Bali, and we support them."
Craig Beveridge, CEO of BIMC Hospital Group termed the visit of the Minister a great honor for the BIMC team and was enthusiastic over the Minister's support of advancing health services in the Republic.
Beveridge said the Minister was very enthusiastic during her visit and pushed for Bali to move forward with its plans to development medical tourism.
Related Articles
[Medical Tourism Comes to Bali]
[Medical Tourism in Bali]
[Bali: In Sickness and in Health]


text:
Project DescriptionHighmark employs over 2,000 people, and the new Dining/ Foodservice areas provide a comfortable & relaxing atmosphere for gathering for meals, snacks, & shopping for gift items. The space formerly occupied by the Bluetique gift shop was incorporated into the new Health Place, a well-equipped health and exercise facility which was renovated along with the Dining / Foodservice. The expanded store continues to provide gourmet coffee along with a variety of gift merchandise. The expanded location also provides a selection of "grab and go" menu items for breakfast and lunch, and an adjacent small café provides limited seating.
The kitchen provides a variety of dining options from sit down meals to take out. New equipment, along with some existing equipment was configured to streamline the preparation & delivery of food. A new contemporary dishwashing and waste collection room was also incorporated.
The new multi-station serving area incorporates an expanded grill, deli, pizza and hot menu items, and the soup and salad stations were expanded to offer takeout items. A primary goal of the design was to eliminate the need to stock food, drinks, and condiments on the public side, and the design allows restocking from the non-public side of the serving stations.
A major portion of the existing patio was enclosed to expand the dining area to accommodate 775 seats. In addition to the tables and chairs, a series of high counters with stools are provided.. The remaining patio area has been redesigned to provide a relaxing alternative to the indoor seating areas with views of the surrounding mountains and woods, and a trellis provides an area of protection from the sun.
The Fitness Center was designed in response to an initiative from the Administration to provide a state-of- the-art facility for their 2,300 employees on the Center Street Campus. The new 2,800 square foot full service fitness center, houses a full complement of both free weights, and machines. Personal trainers & dietitians develop personalized programs for each member.


text:
This section will be updated regularly with items for sale. Check back again later to see what's new in stock.
These pieces are in stock and ready to be sent out. All pieces are hand made, and usually ready to wear with straps/ buckles, and or gloves linings installed.
You can contact me at email@example.com if interested for purchase, or have any questions. I can take check, money order or paypal.
I also have other pieces not listed here; Stainless shoulders, elbow cops, knee cops, splints and other parts for folks who want to make there own equipment. E-mail or Facebook me and I will be happy to see what I can do for you. Best, --Jeff
Marked with a crown.
Articulted on pivoting rivets in the back and leathers in the front, these offer excellent mobility and protection. Buckle is handmade and strap and tab are of high quality latigo.
Price $350.
Price $850.
Made of 21 gauge spring steel, so they are super lightweight. They have holes punched for straps, buckles and mounting. click on the photo for a higher res picture. These have an inner wing to protect the inside of the knee as seen on English armor of the early 15th c.
Price: $480.
Price: $250.
Price: $120.
SOLD! can make more.
Price: $250.


text:
Hello, everyone -- hope your week is going OK so far. Last night I watched the new comedy Bachelorette. Despite its solid cast -- Lizzy Caplan, Kirsten Dunst, Isla Fisher, Rebel Wilson -- it manages to be one of the messiest, most tedious movies I've seen all year. Try to resist the allure of these ladies if you can; you're better off watching Bridesmaids for the 23rd time.
A few headlines:
- Sad news: Ron Palillo, aka Horshack from Welcome Back, Kotter, has died.
- Raiders of the Lost Ark is being re-released in IMAX theaters.
- Stan Lee answered questions on Reddit yesterday.
- Here's a list of the 25 best sports movies of all time.
- Devo has written a song about Mitt Romney's dog.
- Here are some new Beck tracks that appear in a Playstation 3 game.
- "Ed Asner's 10 Geekiest Voice-Acting Roles."
- What are the best indie songs of summer?
- Watch a trailer for a new flick starring Winona Ryder and James Franco.
- Get ready for Top Chef: The Cruise.
- And finally, check out the Ryan Gosling coloring book.
Whitney has been writing about pop culture for USA TODAY since 1999, when Pop Candy began as a weekly column. Her interests include music festivals, mustaches, Lost, comic books and Andy Warhol. She lives in New York City. More about Whitney | E-mail Whitney


text:
In general, what's the customer feedback on Stock 'n Go? Have they been reviewed by blogs and news sites?
0 answers
Add an answer to this question
Today's best Stock 'n Go promo codes
Today's best deal
Stock 'n Go is offering a storewide coupon on their website. For a limited time, you can free standard shipping on all orders at Stock 'n Go. To use this offer, go to stockngo.com, add items to your basket, and then go through checkout. This promotion was activated 7 months ago and it is an ongoing deal. For additional Stock 'n Go coupon codes, see the index at Dealspotr.
Added 7 months ago — Ongoing deal — Coupon details — More Stock 'n Go promo codes
More Stock 'n Go Discussions
Does Stock 'n Go offer discounts to military families and veterans?
You can check this page for more information about Stock 'n Go's veteran discounts and offers. You might also check out their homepage to see if they've posted any additional information about their military discounts. You can also subscribe to their email newsletter, as some stores will send specia...
Stock 'n Go's military discount policies are rated:
3.0 - 1 rating
Does Stock 'n Go offer free shipping?
Yes, Stock 'n Go does ship for free every day of the year. Stock 'n Go does require that the order meet the minimum purchase requirements. You can find out more about Stock 'n Go's shipping policies on their website on their shipping policies page. Hope this helps! If you can't find the inform...
Stock 'n Go's shipping costs are rated:
4.0 - 1 rating
Does Stock 'n Go offer free returns? What's their exchange policy?
Yes, Stock 'n Go does offer free returns and exchanges. This applies to items purchased online and in store. If you want more information on their returns policy, you can visit Stock 'n Go's page here.
Stock 'n Go's returns & exchanges policies are rated:
5.0 - 1 rating
Does Stock 'n Go offer a mobile app for iPad, iPhone and Android?
Stock 'n Go is an online shopping website that sells various beauty and personal care products. Unfortunately, they do not offer any mobile applications for iPhone, iPad, or Android mobile devices.
Does Stock 'n Go offer a mobile app for iPad, iPhone and Android?
Stock 'n Go is an online shopping website that sells various beauty products like hair care, fragrance, skin care, personal care, health care and more. Unfortunately, the company does not currently offer mobile applications for iPhone, iPad and Android mobile devices. Phone: 1-877-786-2564 For mor...
What is Stock 'n Go's return / refund / exchange policy?
Stock 'N Go has a 30-day return and exchange policy which is valid from the delivery date of your items. You will need to contact them for a 'Return Authorization Number' and return label by emailing them at firstname.lastname@example.com. They prefer that you return your item(s) in the original ...
Does Stock 'n Go accept debit cards or personal checks?
At the current moment in time Stock 'N Go does not accept personal checks. You are given the option on check-out of paying with a variety of differing credit cards such as Visa, MasterCard and American Express cards and if you have a debit card that displays any of these symbols it can be used...
Does Stock 'n Go ship internationally? Which countries do they ship to?
Stock 'N Go do not ship to international destinations but they do ship all over the US, including Hawaii and Alaska (although free shipping does not apply to these two states). They do not ship to Puerto Rico, military APO/FPO addresses or PO Boxes. For all orders within the US bar the two sta...
Does Stock 'n Go accept PayPal?
Yes, Stock 'n Go does accept PayPal as one of their payment options, They, in fact, recommend PayPal Checkout as it is very safe and easy to use. If you don't have a PayPal Account, creating one will take only a minute of your time and it is certainly worth it for your future online transactions.


text:
WAlKERS from Clows Top and Callow Hill will be pounding the streets of London to take part in an overnight marathon for a breast cancer charity.
Mother and daughter Julia Woodison and Laura Cripps, of Clows Top, and community nurse Angela Allan, of Callow Hill, will be taking on Walk the Walk's MoonWalk on Saturday, May 10.
The event will see 17,000 women walk 26.2 miles around London, with many stripping down to their custom-made bras to raise awareness of breast cancer.
Miss Cripps, 24, said: "This is our sixth year, it's something we look forward to. It's in London at night and you see all the landmarks and there's a massive party atmosphere.
"You meet other people and that kind of spurs you on, it's a completely different experience.
"One of the main reasons is for fitness but we also know people close to us who have died from breast cancer so that spurred us on to do something active and fundraise for the cause."
Miss Cripps and Mrs Woodison, 49, need to collect £100 each as a minimum but always try to get friends and family to sponsor them as much as possible.
Mrs Allan, 58, is taking part in the MoonWalk for the first time with a team, including her sister-in-law, from Kent.
She said: "Here I am, a woman of a certain age approaching my sixth decade, a time to reflect on life.
"I have a wonderful family, extended since remarrying four years ago. The arrival of grandchildren and the opportunities to travel made me realise how lucky I am.
"Walking 26 miles sounded impossible but with the encouragement of my family and friends I have been training since January, walking locally around the roads and lanes.
"It's not as daunting as I first thought with the bonus that I am healthier and fitter and so is my husband, who accompanies me.
"This is my opportunity to help others, women I will never know."
To sponsor Mrs Allan visit walkthewalk.org, click on sponsor a walker and type in Angela Allan or to sponsor Miss Cripps and Mrs Woodison visit justgiving.com/juliawoodison-lauracripps


text:
I Was a Princess for a Day for the People's Choice Awards
Getting glamorous is hard work! But seeing stars up close is worth the pain!
-PJ Gach
Unlike me, Vanessa Hudgens probably doesn't have to give her dress back!
"There's a concession stand in the Nokia Theater!" was my first thought when we walked in to the People's Choice Awards. Who knew? As we took our seats (Orchestra, no less!), I kept wondering if you could run out, grab a drink and some popcorn and munch away during the show. As it turned out, commercial breaks were so short, that there'd be a really good chance that you'd get stuck outside missing the action until the next commercial break. Since this was a once in a lifetime deal, would you really want to miss anything for a hot buttery bit of popcorn? Nah. Besides, after we left, I realized they weren't selling any.
Read 2012 People's Choice Awards: The Gorgeous, The Fierce and the … Hmmmm
How did I get to be here in the first place? Good question! The gods smiled down upon me and granted my wish to go to an award show and have fun! Honey Bunches of Oats invited an editor from BettyConfidential as their guest, to celebrate their sponsorship of two new categories at the People's Choice Awards: Best New Drama and Best New Comedy. Oh course I said yes, yes, yes! Then I ran around like a mad woman trying to get ready — read my story of prepping before leaving NYC here (it involves manicures and panicking).
Wednesday morning, the day of the show, the car was downstairs in front of my building at 5 a.m. ready to take me to the airport. As I'm zipping up my suitcase—I had been packing on and off throughout the night—the zipper breaks! I'm sweating bullets right now and teetering on my brand new red suede 5-inch Geox wedges that I just had to have to fly in … sometimes I get the oddest ideas. The car's downstairs, the dog is barking and I am losing my mind. I run back into my bedroom, grab another suitcase, up-end everything on bed and proceed to re-pack in like, oh maybe 20 seconds. A side note: New Yorkers don't have much space in their apartments, so we use suitcases to store summer clothes.
After boarding the plane, I promptly fall asleep and snore. Um, my excuse and I'm sticking to it is that I have a cold. Val, my fellow guest from Glam.com, and I share a car from LAX (just saying that name makes ME feel oh so glam) to our hotel. We check in and meet up with Patricia, who's our tour guide / mama hen / PR person for Honey Bunches of Oats.
The afternoon is a complete blur. We run to grab a bite to eat — what an incredible luxury to have lunch under the brilliant Californian sunshine in the middle of January! We then run — and I do mean run — to the Ritz Carlton for hair and makeup. There's nothing like being pampered when someone else gets to fight with your hair! Really, between the incredibly sweet and patient makeup artist and the hairstylist, I felt like an A-lister.
We run back to the hotel, get changed and all meet up in my room. Can I just say right now, we looked glam, glam, glam! Suddenly I have my very own People's Choice Awards ticket in my hand. I'm so happy I start kissing it. I am also praying that they don't take it from me. What happens when you get three women together? You run late. It's a fact, we're all so giddy about going to our very first awards show EVER, that we keep posing and giggling and giggling and posing…you get the idea.
The line for the theatre is huge a giant U-shaped snake. Unlike New York, people are quiet (think church quiet) and orderly. As we're online, we keep hearing screams and yells from the front of the Nokia. Every time a star walked on the red carpet, the crowd erupted.
Finally, we're in! That's when I see not one, not two, but like four concession stands. Our bags are checked, we're scanned and we're on our way to our seats.
OMG! We're sitting 10 seats back from the stage. The other side of the orchestra is filled with celebs. We're craning our necks and twit-pic'ing madly. I get caught spend the rest of the night trying not to get caught again as I snap celebs and post to Twitter.
The lights dim, the announcer announces the start of the show. All my exhaustion dissipates. As one, Val, Patricia and I are sitting straight up, waiting for the second that Kaley Cuoco appears.
And the show! To see it live is incredible. You notice that everyone is thin and gorgeous. And everyone is short except Kelly, Liam Neeson and Faith Hill.
There are times when Kelly is talking onstage and we can watch the crew setting up a band or moving things around. The commercial breaks are much shorter than when you watch it on TV. As celebs are getting ready to go on the stage, they congregate by our side. However, every time I try to snag a photo with my cellie, either the dreaded security guard immediately glares at me or someone in a row ahead of me pops up. It's enough for me to want to start playing "Whack A Mole!"
When Betty White and Emma Stone win their awards, they both get a screaming, rowdy glee-filled ovation. I had no idea that Betty is going to be turning 90 soon. I can only hope that I can have a least an ounce of her energy, her star-style and goodness when I get up in years.
Also – I love that Emma bucked trends and wore pants.
As for Demi Lovato: I gotta say, even in person, the red hair is not her. But her talent, her drive, as she performs … I'm rooting for her to rock it out. I think we all are!
Read The 7 Most Memorable Moments of the People's Choice Awards
What can I say about Ewan McGregor on stage — I think all the women swoon when he appears. It's that sexy Scottish burr, it makes you purr. That man can wear a scarf.
When I see a hairless Rob Pattinson go up on stage to pick up the award for Water for Elephants, I dodn't recognize him. Without his hair, he looks a little pudgy.
As a gal who loves dress up, I'm torn between looking at people onstage in their red carpet finery and what people are wearing in the audience. To me, the most fun is seeing little kids in sequins and dress-up clothes clutching their mommy's hands. I love seeing little kids in suits and dresses watching the evening unfold with huge eyes and big smiles on their faces.
As I mentioned, Honey Bunches of Oats sponsored two categories for the first time — Best New Comedy and Best New Drama. When Two Broke Girls wins, honestly, there are tons of "I Love Yous" from the audience. I'm really hoping to see the hot stars of Person of Interest when they win Best New Drama, but they were filming.
Speaking of hotties — the guys from Vampire Diaries have all the gals screaming. And let me tell you that after seeing Hunger Games' Josh Hutcherson, the line for the movie just got longer!
Then suddenly it's over! Confetti rings from the skies…no, I'm just being poetic, from the top of the theater, the light goes out, then back to daylight bright and my carriage turns back into pumpkin!
We all trooped back to my room and got a little crazy with room service. The Honey Bunches of Oats people placed their new Fruit Blends cereals in my room for my arrival –peach raspberry and banana blueberry blend. We decided to get bowls, spoons and milk brought up to the room for a snack before dinner. Then we called room service again for something else. Then it was "Hello Gach party, what else would you like?"
Ahem, the time change makes you a tad crazy. So we waddled off to Katsuya for sushi, looked for stars, waddled back to the hotel and passed out.
The next morning felt like the end of camp. We were all going back to our everyday lives. No award shows, no red carpet dresses, no makeup artists making our eyes soo big! Big sigh!
I'm now in Beverly Hills! I'll be sending in reports about gorgeous jewelry and incredibly cool gifting lounges for the Golden Globes.
It's a dirty job, but someone has to do it!
PJ Gach is Senior Editor: Style + Beauty at BettyConfidential.


text:
Samantha Harris: Women's Running July 2013 Cover Cutie
In between her motherly duties and her healthy lifestyle, Samantha Harris took a beat to front the July 2013 issue of Women's Running magazine.
While flaunting her flawless abs for the cover shoot, the former "Dancing with the Stars" host revealed how she became the running machine she is today and even offers advice for those who fear the sport.
Check out GossipCenter's recap of Miss Harris' interview below. For more, be sure to visit Women's Running magazine!
On picking up running for the first time:
"I never thought of myself as a runner until I started dating my now-husband. On one of our first dates, he suggested that we go out for what I thought was going to be a walk, but he suggested we run. In a new relationship, you always want to try new things, so I thought I might as well. I was really surprised at how much I enjoyed it."
On a healthy running tip:
"Running is intimidating! When you're first starting, tell yourself that it's okay to walk if you need to. if you allow yourself that pass, it's a lot less daunting. If you do a a race and have to walk, you won't be the only one. it's a mater of finishing - not getting there first."
On running charity 5k's:
"One of the first 5ks I did was for Susan G. Komen. We rallied a team together to support my grandmother, who's a nearly 30-year cancer survivor. Seeing all these women coming together for a united cause while doing something that's healthy really moved me. I also trained for and hosted the March of Dimes' 5k Run for Babies, the goal of which is to improve the health of infants. I am thankful I didn't have preemies, but going through childbirth made me see the importance of prenatal care and the fact that so many women don't have access to it. The race was amazing. When you're running for a cause, there's something greater than the end goals, and that's incredibly motivating."
On Hollywood pressures to stay in shape:
"Because of my career, there is definitely pressure to look a certain way. But even if I was never going to be in front of another camera again, I would keep running. It's part of my life. It helps my mental acuity and my personal betterment. Plus, it's a way for me to give back and to be a good example for my children. After doing a race for Feeding America, I started volunteering with my older daughter at the Sova Food Pantry stocking the shelves. i hope one day she'll do a race with me as well!"
Photo Credit: Women's Running


text:
I have finally had the staples taken out of my head. (Staples are the new version of stitches.) So I no longer feel like I'm sleeping on a handful of safety pins. I'm also getting used to people trying to get blood samples out of my tiny veins. I am afraid I have a rep among the phlebotomists around here!
I still can see very little in my left peripheral field of vision, but I have added a new ingredient to the mix: hallucinations. I will be lying in bed, when all of a sudden I will "see" a row of people stand up to attention, as if they are having a meeting in some military context.
Of course, this is not really happening, but it looks to me as if it is, and it's so convincing that for a moment I buy into it each time. Many of the hallucinations feature small people who seem very real, and leave me wondering just exactly what is going on. Are they the origins of fairy lore? Am I hallucinating, or seeing real things in another world? My guess is that it's hallucinations. The doctors are familiar with this as a sequel to the surgery I had, and expect that it will fade away in time. In the meantime I can take medication that will make them go away, or at least bother me less.
I'm fortunate that the weirdness has a name. It's called Charles Bonnet Syndrome, because it was first described by a Swiss doctor of that name in 1769. Some people have it for years, but for most of us it fades in a few weeks or months. Hopefully, I'll be in that group, but if not, well, having fairyfolk traipsing through your life isn't the worst side effect of lifesaving surgery.
One thing about the brain: it's not amused by somebody going into it with a surgeon's scalpel, and it lets you know that.
I love your closing line, Anne: " the brain: it's not amused by somebody going into it with a surgeon's scalpel..." In my community, we'd respond, "I know that's right!" Blessings to you for a successful surgery; I pray your recovery will be full & complete. Also, did you consider NOT taking the medication & instead, experiencing the hallucinations--allowing them to lead you to deeper exploration?
Hi Anne, nice to hear you are doing better.
Without getting into epistimology and the definitions of reality vs hallucination, I would suggest you simply try speaking to these beings and perhaps offering them some water.
You might also try putting out a peice of paper and see if they won't write something on it. communications, Leaving offerings and "spirit signatures" are a little known but once common practice with spirit beings that were once called "faries".
(Light can sometimes make it harder to see them so try wtih the lights off or low. )
Let's just assume it's all in your head. You still might be able to get some interesting effects from it and perhaps even heal yourself this way. Perhaps this is a way for your conscious mind to speak with the unconscious and even the physical brain?
Of course it's possible they have always been there and you are just now seeing them.
or it could be in your head.
...Or It's all in your head and we don't realize how big our heads are.
anyway, if it works I would love to hear from you.
Be well!
Thinking about you, Anne. Glad to know things went ok. Hope you feel better soon.
It's getting better all the time
Better Better Better
It's getting better all the time
Better Better Better
Getting so much better all the time
Well, we are very glad recovery is happening. What weird things the brain does. Let's hope its very short-term. That's gotta be annoying as heck.
Vedrai tu che domani sia migliore per sempre, che non sei mai da solo. Abbi gioja...
God hold you in the palm of her hand and make room for Whitley as well.
I'm glad that you are recovering and well for a long time, hopefully.
I wish that I could see you and everybody else in Memphis. Once again, it looks like maybe next year for me.
Feel Better Anne, keep us updated!
Anne, here is a video of Oliver Sacks discussing Charles Bonnet Syndrome. It's quite fascinating. I hope it answers some questions for you and eases your mind.
In the meantime, you and Whitley are in my thoughts and prayers. Blessings.
Hi Anne...what wonderful comments you are receiving...very loving people are here:)
About your visitors...why not pretend they are for real and are working on you...for the good...and just observe. Just sayin' :) V.
I am holding you in the Light! I know you will make a speedy recovery! Thanks for continuing to share your experiences with us. Love the beautiful comments your receiving.
Anne, thinking of you this evening and praying that you are healing.....
Your strength and the positive way you face your challenges are great examples to be followed and a gift for us all. Be blessed and recover soon!


text:
The question this month is: What is your favorite quotation?
Well, there are lots of quotes I absolutely love. I don't even know how to pick just one favorite. Just look over there on my sidebar --> where I keep track of awesome quotes I hear that mean something to me (or Zay) throughout our adoption and parenting journey. I add to it all the time.
If I had to highlight just one, I would go with the one that has driven me lately:
"Women are like lionesses at the gate of the home." -- Julie B. Beck, BYU Women's Conference (talk is found HERE)
|"Modern-day Mother in Zion"
Photo: www.twhtsricketyeasel.blogspot.com
It surprises me how much the world will try to tear at your family. When I was young and naive, I thought you get married and you live happily ever after in a state of safety and bliss. Ha ha. Not so.
People don't always value your marriage/family as much as you do.
People don't always value the time you spend with your family like you do.
There are many "intruders" that can try to seep into your home and family and break it down or distract you:
- Outside responsibilities that intrude upon your time with family, including important things like work and school
- Addictions (drugs, alcohol, pornography, food, *technology,* etc.) that eat away at your ability to be present in your family
- "Friends" who do not uplift you or encourage you to be your best self or take up too much of your time
- Over-scheduling and participating in too many "good" things, including Church
- Toxic emotions, including insecurity, jealousy, or discouragement from comparing your family to others
- Listening to marriage cynics who don't understand the importance of and the happiness that can be found in marriage
- Falling victim to "Mommy Wars" - women attacking other women for their choices in child bearing and rearing
- Uncontrolled mental health issues (depression, anxiety, etc.)
- Infidelity - not keeping a close watch on your mind and heart, allowing yourself to be in sketchy situations
- Ex's, or unresolved/lingering past relationships
- Extended family who are an unnecessary burden on you
- Selfishness, laziness, impatience, uncontrolled temper, etc. etc. etc.
- Anything that contributes to loss of faith and not relying on the Lord
"Women are like lionesses at the gate of the home."
What threats against marriage and the family have you seen lately?