text:
A month ago, the market's priced-in probability of the Reserve Bank of Australia increasing interest rates tomorrow was just 34 per cent. By last Friday, it had risen to 50 per cent, and the only surprise was that it hadn't gone slightly higher. The argument for the RBA making the next move of 0.25 of a percentage point in its tightening cycle has been building for a month – and so has the mood music from the RBA: deputy governor
The key factors in strengthening the case for a rate rise are two months of very strong employment growth, a continuation of the trend improvement in business credit growth, and the very strong outlook for mining investment in 2010-11.
Forget the Greek crisis. It is true that if Greece defaults, it will be a disaster of the order of the Lehman Brothers collapse. There will be fears that Ireland, Portugal and even Spain and Italy will follow. Confidence will collapse, the banks will stop lending, and the world will be back almost at square one.
But a Greek default is a low-probability, high-impact event. All that Australian policymakers can do is focus on the central scenario – which is a recovery – while being ready to take radical action in the unlikely event that Greece "blows up".
It is the domestic economy and the Asian outlook that will drive tomorrow's decision.
The RBA board minutes describe the decision in February to keep interest rates on hold as "finely balanced", and in truth nearly all monetary policy decisions are. But the fact that the ex-RBA and
ex-Treasury economists employed in the financial sector were unanimous in predicting a rate rise in February suggests that last month's decision was more finely balanced than most. And so it should have been.
As the RBA acknowledged after the board meeting, economic conditions in Australia were stronger than expected with demand supported by a strong infrastructure and mining investment, surging employment and rising household net worth.
One of the economists' few concerns about the domestic economy in the period leading up to the February meeting was the weakness of business credit. It had fallen more in the year to November than it had in any of the recession-affected years of the early 1990s.
And while the recent monthly data seemed to indicate that the worst of the business credit slump was over, with no pressure on the bank from inflation, there obviously was an argument for waiting to see if the improvement continued.
Well, it has. The decline in business credit was only 0.1 per cent in January, compared with 0.3 per cent in December and 1 per cent in November.
The big jump in mining investment expectations for 2010-11 should further help reduce concerns about the investment outlook. The outlook for manufacturing and service sector investment still looks soft, but the surge in spending by the mining sector will be a powerful tonic for the economy.
What else would it take now to push the RBA across the line?
As was the case at the time of the February board meeting, the key issue at this week's meeting will be the strength of demand after the end of temporary tax concessions and subsidies on business investment and housing in 2009.
On balance, the data for January seems pretty encouraging.
One of the most positive – and important – indicators is the January labour force survey. It showed an increase of almost 53,000 in employment, and a fall in the unemployment rate of 0.2 percentage points to 5.3 per cent. That followed December's jump of 37,500 in employment and a fall of 0.1 percentage point in the unemployment rate.
Of course, there are question marks over the labour force data. The new data series on hours worked is weaker than the headline employment data. Perhaps employers are hedging their bets by hiring more workers on short hours. But there is no sign of employers desperately cutting working hours to stay afloat, and any weakness is likely to be temporary. The National Australia Bank's January business survey indicated the labour market was pretty strong.
At the very least, the balance of risks has shifted towards a tightening of the labour market.
The fall in the unemployment rate will also be good for consumer confidence, as will the continuing rise in house prices. RP Data Rismark estimates that home prices rose by another 1.8 per cent in January and are now up 11.8 per cent over the year.
Of course, there are still areas of concern. The NAB's January survey showed a general deterioration in business conditions (not surprising after the artificially inflated December quarter), including a sharp decline in retail conditions. The January retail sales numbers will be pe published tomorrow as the RBA board meets. Economists also point to a decline in housing loan approvals, not just for first-home buyers, but more generally.
So the RBA might find reason to continue its pause. Yet as the economy increasingly takes the shape of the world described by the bank's deputy governor, pauses might be seen as a luxury better saved for later in the tightening cycle.
The Australian Financial Review


text:
To say that the scene in Cairo is a far cry from New York would be an understatement.
In an understatement, Dwight Normile, editor of International Gymnast magazine, said of Khorkina: "She was very unique."
To say that these people are more dedicated to U.S. politics than Americans is an understatement.
" Sex and the City loves labels," she said, in the understatement of the century.
Displaying his usual gift for understatement, Glenn Beck called her "a monster."
I perceived Wenceslaus, in a moment of understatement, to be more than a little disaffected.
Taken literally, however, it was an understatement of the facts and wholly insincere.
The dryness in his tone was a paragraph of comment on my understatement.
Many times was an understatement, Latham thought wretchedly.
He is given rather to understatement than overstatement of facts—a cool, level-headed observer.
A form of irony in which something is intentionally represented as less than it is: "Hank Aaron was a pretty good ball player."

subset: commoncrawl


text:
March 11, 2009
Countries that protect the physical and intellectual property of their people enjoy nearly nine times higher gross domestic product per capita than countries ranking lowest in property rights protections, according to the "2009 International Property Rights Index (IPRI). The study compared the protections of physical and intellectual property to economic stability in 115 countries representing 96 per cent of the world's gross domestic product (GDP).
The 2009 IPRI is a composite ranking of three comprehensive areas of property rights: Legal and Political Environment, Physical Property Rights, and Intellectual Property Rights:
- Of the 115 countries included, the top quartile averaged $39,991 in GDP per capita while the average in the bottom twenty per cent was only $4,341 per capita.
- The second, third and fourth quartiles averaged $23,982, $11,748, and $4,891 respectively.
- The nearly linear data trend shows that countries placing a high priority on property rights see increased economic security.
"With regard to private property rights, PRA continues to champion the idea that physical and intellectual property are equally important in nature, and must be protected" states Kelsey Zahourek, PRA executive director. "Property rights contribute to increased levels of stability and provide people with the knowledge and comfort that their property will remain theirs."
Hernando De Soto said this year's results "continue to point out the relationship between a strong property rights system and a country's economic well-being, revealing that much still needs to be done to extend property rights to more people, especially the poor."
Source: Anne Chandima Dedigama et al., "International Property Rights Index: 2009 Report," Property Rights Alliance, February 24, 2009.
Browse more articles on International Issues


text:
McCarron, Dockett back at it on Twitter
Darnell Dockett is a
persistent one. A few weeks after his headline-generating
Twitter shenanigans with Miss Alabama Katherine
Webb and then her boyfriend, Alabama quarterback A.J. McCarron, Dockett
was back it Friday while in New Orleans for Super Bowl
Despite saying last week in
a radio interview that Webb wasn't his "type," he
sent the following tweet to Webb, who's at the Super Bowl working as a
media personality for "Inside
Aye @_katherinewebb we
still on for lunch. I'm suggestion a spot in calliope projectsbring Lil
AJ too! My boyz will keep him comapany.
(@ddockett) February
1, 2013
FYI, the Calliope projects
are housing projects in central New Orleans known for having a
horrifyingly high violent crime rate. Of course, Dockett's very first
proposal to Webb was to take her out for wings and a night at a strip
club, so his typical date agenda apparently isn't quite like mine or
Anyway, while McCarron has largely taken the
high road throughout the whole thing, Dockett's most recent overture to
his lovely lady generated a couple not-exactly-high-road responses
within a matter of hours:
@ddockett Pro player and
u gotta try & be twitter thirsty! I saw you today bro with
Katherine looked dead at you & u didn't say a thing!
AJ McCarron (@10AJMcCarron) February
2, 2013
@ddockett and come to
mobile sometime if ya want to! I got plenty of boys that will keep u
company! #real
AJ McCarron (@10AJMcCarron) February
2, 2013
#real indeed. Dockett hasn't
responded to those tweets, although based on his other Twitter
activity, it appears he's staying plenty busy with various, um,
Got pulled over by police, doing 150
in 65 ! Told him I'm late for a mtg!he said what mtg? I said hunting
w/my white friends! No ticket gone
(@ddockett) January
31, 2013
RT @dubcart: @ddockett did you hit up
the strip club.—– yeah i left when some dude said free
C-murder….Knowing he got life "time2go"
(@ddockett) February
2, 2013
The oh-so-appropriate
"that's just Manny being Manny" might soon be replaced in the
sports-world vernacular by "that's just Dockett being
FOX Sports Go


text:
Ask an Eye Doctor and Get an Answer ASAP
I would advise you to see an ophthalmologist again. There are a few possibilities with these symtoms and these include allergy, contact lens intolerance or infection. You may require anti-biotic or steroid drops. Till then you can use a lubricating drop like Refresh Tears. Thanks and best wishes.
Please, click the ACCEPT BUTTON so that I can get my dues. BONUS and a POSITIVE FEEDBACK will be appreciated.


text:
Bartzokis G, Cummings J, Perlman S, Hance DB, Mintz J. Increased Basal Ganglia Iron Levels in Huntington Disease. Arch Neurol. 1999;56(5):569-574. doi:10.1001/archneur.56.5.569
© 2017
To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects.
Design and Subjects
A magnetic resonance imaging method that can quantify ferritin iron levels with specificity in vivo was employed to study 11 patients with HD and a matched group of 27 normal controls. Three basal ganglia structures (caudate, putamen, and globus pallidus) and 1 comparison region (frontal lobe white matter) were evaluated.
Basal ganglia iron levels were significantly increased (P<.002) in patients with HD, and this increase occurred early in the disease process. This was not a generalized phenomenon, as white matter iron levels were lower in patients with HD.
The data suggest that increased iron levels may be related to the pattern of neurotoxicity observed in HD. Reducing the oxidative stress associated with increased iron levels may offer novel ways to delay the rate of progression and possibly defer the onset of HD.
HUNTINGTON disease (HD) is a genetic disease caused by the repetition of a CAG trinucleotide sequence encoding for a polyglutamine tract at the N terminal of the gene coding for a protein of unknown function named huntingtin. Despite our understanding of the genetics of HD, the pathogenesis that results in the observed phenotypes remains puzzling, encumbering the search for therapeutic interventions.
Except for juvenile onset cases, where the disease may be more virulent, the rate of progression of HD is not affected by the CAG repeat number1 or the presence of a double dose of the gene in homozygotes.2 This suggests that the mutant genes contribute to reaching the threshold of neurotoxicity, and once the threshold is reached, the progression is dependent primarily on nongenetic factors.3 Supporting this contention are the observations that the defective gene and its protein product are expressed throughout development, are ubiquitously present in most brain areas as well as the periphery, and are not noticeably present at higher levels in cells that degenerate first.4 In contrast, the typical HD phenotype is characterized by middle to late age of onset and by early, specific neurodegeneration of striatal (caudate and putamen) neurons. These observations suggest that some of the nongenetic factors are specific to the central nervous system (CNS) and that, therefore, a CNS-specific risk factor such as a CNS-specific neurotransmission could be involved.5 In addition, the above observations suggest an age-related risk factor that may predispose the striatum to the earliest and most severe involvement. The striatum is a site of high iron concentrations that increase with age from very low levels at birth,6 and several postmortem studies have found increased iron levels in the striatum of patients with HD, suggesting a role for iron in the HD process.7- 9
Whether elevated levels of iron are present prior to death is an important scientific and treatment question. An association between high iron levels and CNS damage has been observed in a variety of neurodegenerative disorders, and iron involvement has been suggested as a common risk factor.10- 12 Up to 90% of nonheme iron in the brain is in the iron storage protein ferritin.6,13 Magnetic resonance imaging (MRI) can measure tissue iron in vivo through its effect on transverse relaxation times (T2). Ferritin has been shown to exert a strong magnetic effect that results in marked T2 shortening both in vitro and in vivo.12,14- 17 An attempt to use MRI to confirm the markedly elevated basal ganglia ferritin concentrations detected through biochemical analysis of postmortem brain samples of patients with HD has failed to reveal the expected T2 shortening.9 This result was not unexpected because T2 shortening is not specific for tissue iron, and many tissue changes, such as changes in MRI-visible water and tissue density, can affect this measure.12,18- 20
Recently, we used a new technique called field-dependent relaxation rate (R2) increase (FDRI) to quantify brain iron levels with MRI.15,21- 23 Briefly, FDRI is the difference in measures of tissue R2 obtained with 2 different field-strength instruments (1.5 T and 0.5 T). In the presence of ferritin, R2 increases with increasing magnetic field strength.15,16,21- 26 This field-dependent R2 increase is specifically associated with the total iron contained in ferritin molecules,15,16 and has been shown to be independent of the amount of iron loading (number of iron atoms per ferritin molecule) of ferritin25 and to increase linearly with field strength.16,25,26 Thus, the FDRI measure is a specific, albeit indirect, measure of total iron contained in ferric oxyhydroxide particles that form the mineral core of ferritin molecules. In human tissue, ferritin and its breakdown product, hemosiderin, are the only known physiological sources of such particles and will hereafter be referred to as ferritin iron.16,17,22,24 Finally, using a nonhuman primate model of hepatic hemosiderosis, investigators recently demonstrated a very high correlation (r=.94) between liver tissue iron levels and field-dependent changes in R2.17
Seventeen patients with HD were referred from an urban university neurology clinic and, after being fully informed of the study, agreed to participate and gave written consent. Eleven white subjects (7 men and 4 women) completed the study. These subjects ranged in age from 25 to 67 years (mean age ± SD, 46.2 ± 11.9 years) and were symptomatic from .75 to 20 years (mean ± SD, 7.8 ± 6.3 years). Prior to referral into the study, the subjects with HD underwent complete clinical assessment and the diagnosis was confirmed by an experienced neurologist (S.P.) via a thorough review of the history and clinical evaluation. All subjects with HD had a family history and/or a genetic test positive for HD. The 9 subjects who agreed to undergo genetic testing had a positive test result, with expanded CAG trinucleotide repeat sequences ranging from 40 to 54 repeats (mean ± SD, 45 ± 4.6 repeats).
Severity of choreoathetoid movements was assessed with the Abnormal Involuntary Movement Scale,27 on which scores of subjects with HD ranged from 9 to 24 (mean ± SD, 17.1 ± 4.3), and severity of dementia was assessed with the Mini-Mental State Examination,28 on which scores ranged from 20 to 30 (mean ± SD, 26.7 ± 2.9).
To control for the effects of age on the dependent measures, we selected cases from a pool of normal control subject volunteers recruited from the community and hospital staff who were participating in an ongoing study of normal aging and were recruited through printed advertisements. Normal subjects were excluded if there was a family history of Alzheimer disease, HD, or other neurodegenerative disorders, or a history of head trauma resulting in loss of consciousness for longer than 15 minutes. Normal subjects were included if they fell in the demographic parameters (age range and race) of the HD group and none was excluded on the basis of MRI findings. These criteria reduced the sample of 76 normal controls available for the study to a final normal comparison group that included 27 subjects (23 men and 4 women) ranging in age from 26 to 69 years (mean age ± SD, 44.8 ± 16.2 years). The subjects with HD and control subjects did not differ in mean age either in the overall or in sex-specific groups (P>.5).
The methods have been described in detail elsewhere21 and will only be summarized here since the principal difference consisted of the use of a new set of MRI instruments. All subjects were scanned using the same 2 MRI instruments (1.5 T and 0.5 T) (Picker Instruments, Cleveland, Ohio), and the 2 scans were done within 1 hour of each other using the same imaging protocol.
Two pilot sequences were obtained to specify the location and spatial orientation of the head and the position of the axial image acquisition grid. A coronal pilot spin echo image of 100/30/1 (repetition time[RT]/echo time[TE]/excitations), 10-mm thickness, was acquired and used to align the subsequent sagittal pilot images. The middle slice of the sagittal pilot images was aligned on the coronal pilot to obtain a true mid-sagittal image of the brain. After the sagittal pilot spin echo images (550/26/2, 5-mm thickness) were acquired, the midsagittal image was used to position the axial image acquisition grid. The axial image acquisition sequence acquired interleaved contiguous slices using a Carr Purcell Meiboom Gill dual spin echo sequence of 2500/20,90/2 (RT/TE/excitations), 3-mm slice thickness, 192 gradient steps, and 25-cm field of view.
The coronal and sagittal pilot scans obtained prior to the axial image acquisition were used to determine the alignment and accuracy of head repositioning in the second MRI instrument. To consistently position the actual image slices identically within the brain and thus sample the same volume of tissue, the axial slice-select grid was adjusted so that the anterior commissure was contained within the same slice in both high- and low-field instruments. For increased consistency, all subsequent measures were referenced to this slice.21
T2 was calculated for each voxel by an automated algorithm from the 2 signal intensities (echo times, 20 and 90) of the dual spin echo sequence to produce gray-scale–encoded T2 maps of the brain.21
The T2 measures were extracted using a Macintosh-configured image analysis workstation. A single rater, blind to clinical information, obtained all measurements. The image analysis software permitted the rater to delineate the region of interest (ROI) using a mouse. The contour of the entire cross-sectional area of the head of the caudate, putamen, globus pallidus, and a sample of supraorbital white matter was drawn manually by the rater using the gray/white matter contrast of the early echo (TE, 20) images and was then transferred onto the T2 maps.
To obtain T2 measures of homogeneous brain tissue, all pixels with T2 values that fell above the right side inflection point on the histogram distribution of the ROI were eliminated. This minimized the influence of voxels containing small partial volumes of cerebrospinal fluid, which can markedly increase the T2 of the voxel. Thus, the final measure was the average T2 for the remaining homogeneous region of brain tissue.21
T2 data for each of the 4 ROIs were obtained from contiguous pairs of slices. The slice containing the anterior commissure and the slice immediately superior to it were used to obtain the putamen and globus pallidus T2 data. The third and fourth slices above the anterior commissure were used to obtain the T2 data for caudate nucleus, and the second and third slices superior to the orbitofrontal gray matter were used to obtain the frontal lobe white matter data. The R2 was calculated as the reciprocal of T2× 1000. The average R2s of the 2 slices from both hemispheres were the final measures used in the subsequent analyses. The FDRI measure was calculated as the difference in R2
(high-field R2 − low-field R2). Test-retest reliability for FDRI measures was very high with intraclass correlation coefficients ranging from 0.88 to 0.99 (P<.002).21
The mean ages of subjects with HD and normal subjects were similar, but the age distributions of the 2 groups were different (there were few subjects with HD in the tails of the age distribution). To control for any confounding effects of age in the group comparisons, a combination of case matching and covariance analysis was used. Subjects with HD and normal control subjects were stratified into 5-year age intervals (aged 25-29 years, 30-34 years, and so on) separately by sex, and normal subjects who fell in age strata in which there were no subjects with HD were excluded from analyses. This rough matching procedure eliminated gross differences in the age distributions. To control for possible instrument drift or other temporal factors, normal scans were included only if done within 16 weeks of the scanning of a subject with HD. The resulting normal comparison group included 27 subjects.
The FDRI means in the normal and HD groups were then compared using a factorial analysis of covariance design. Because of the known increases in brain iron levels and FDRI with advancing age,6,21 and the possibility that sex may also affect age-related changes in FDRI (G.B., unpublished data, 1998), sex and age (a continuous variable) were included as covariates in the statistical designs. The inclusion of the covariates did not change the results substantively. Separate analyses were done in each of the 4 ROIs (caudate, putamen, globus pallidus, and white matter). In follow-up analyses, a test for the difference between correlated correlations was used to determine whether the standardized group differences in FDRI varied significantly across the 3 basal ganglia structures and the white matter region. Finally, the separate contribution of low- and high-field R2 to the discrimination of the 2 groups was examined in multiple discriminant (regression) models, again controlling for sex and age.
The 2 groups differed in mean FDRI in all 4 ROIs. Controlling for the effects of age and sex, the mean FDRI was significantly higher among patients with HD in the caudate (F1,34=32.58, P<.001), putamen (F1,34=17.67, P<.001), and globus pallidus (F1,34=20.40, P<.001). The opposite was true in the white matter, where the HD mean value was significantly lower (F1,34=6.57, P=.015). The age- and sex-adjusted mean FDRIs (and adjusted, within-group standard errors) in the 4 brain ROIs of subjects with HD and normal subjects are presented in Table 1. In further analyses, we evaluated whether the FDRI differences were present early in the disease by comparing the mean FDRI of the 3 subjects with HD (all men), whose symptom duration ranged from 9 months to 2 years, with normal control men. In the 3 basal ganglia regions, the differences were significant whether the HD group was compared with 3 normal controls matched in age within 1 year (P<.03) or when compared with the entire sample of 13 normal men with the same age range (25-45 years) (P<.001). The mean FDRI did not differ in the white matter (P>.28).
Pearson biserial correlations (partialling age and sex) between diagnosis and FDRI were computed in each region, yielding a standardized index of the size of the group difference, and pairwise comparisons among the 4 ROIs were performed using a test for the difference between correlated correlations.29 The diagnostic effect in the white matter was obviously different from the effects in the basal ganglia regions, being both statistically significant and opposite in direction (all t35, 4.6-6.6, P<.001). The size of the diagnostic effects in the basal ganglia regions were not significantly different (all P>.10). Thus, increased FDRI was specific to the basal ganglia and similar in size in the caudate, putamen, and globus pallidus.
The diagnostic effects in R2 values obtained with the individual MRI instruments (high- and low-field) are summarized in Table 2 and Table 3. Multiple discriminant analyses that included both high-field and low-field R2 and controlled for age and sex confirmed that both field measures independently contributed to diagnostic discrimination in the caudate (high field, t=−5.76, P<.001; low field, t=5.26, P<.001) and putamen (high field, t=−4.57, P<.001; low field, t=5.68, P<.001). In the globus pallidus (high field, t=−3.92, P<.001; low field, t=1.06, P=.30) and white matter (high field, t=3.29, P=.002; low field, t=−1.71, P=.09), only high-field R2 was significant.
The data show FDRI is elevated in the 3 basal ganglia regions and decreased in the frontal lobe white matter in HD. Indeed, the increases in FDRI are considerably larger than those observed in other neurodegenerative disorders such as Alzheimer disease and Parkinson disease.12 The increase in ferritin iron levels is specific to the basal ganglia regions and is significantly different from the changes observed in the white matter region. To our knowledge, this is the first confirmation in vivo of the increased iron levels observed in postmortem studies of HD7- 9 and the first demonstration that the increased iron levels are present early in the disease process. The effect size obtained with the FDRI method is almost twice as great in the caudate and putamen regions that shown by the R2 measured with the high-field instrument alone. Multiple discriminant analyses confirm that combining the R2 measures through the FDRI calculation yields a more specific measure of tissue ferritin iron,12,17 which was a significantly better diagnostic discriminator in the caudate and putamen than either of its component measures alone.
Although the FDRI differences in the basal ganglia regions were comparable in size, interpretation of the separate components of the measure (high- and low-field R2) is also instructive. High-field R2 is sensitive not only to ferritin iron (which increases R2) but to field-independent tissue characteristics, such as the increased MRI-visible water, that characterize tissue destruction and result in R2 decreases.12,18 The low-field R2 measure is much less sensitive to ferritin iron, and thus provides a "purer" measure of changes in MRI-visible water. Increased low-field R2 in the HD group can thus be interpreted as an indication of tissue destruction and is most pronounced in the caudate and putamen, the regions most affected by HD.
The CNS is at especially high risk for damage from oxidative free radical processes catalyzed by iron.30 Toxins that disrupt metabolism and result in increased lactate levels with decreasing pH will release iron from the ferritin stores.31 In addition, increases in reactive oxygen species may also release iron from ferritin31 as do other changes such as increased nitric oxide levels.32 Most hypotheses concerning HD pathogenesis have included a role for oxidative damage.33
Animal as well as human postmortem studies support the supposition of metabolic dysfunction with concomitant oxidative damage34- 38 and/or oxidative damage secondary to excitotoxic neurotransmission.39,40 Excitotoxic damage has been an HD model of striatum cell death for over 20 years. The striatum receives dense excitatory glutaminergic input from the cortex. Glutamate, glutamate receptor agonists, and especially N-methyl-D-aspartate (NMDA) receptor agonists produce toxic effects in the striatum very similar to the lesions seen in HD. However, NMDA receptors are equally dense in the neocortex (superficial layers), striatum, hippocampus, and other regions, while HD is localized primarily in the striatum and leaves areas such as the hippocampus relatively unaffected.41 If NMDA antagonism is involved in HD pathophysiology, another synergistic factor must also be involved in the toxic effects.
The striatum has relatively high iron levels, while the hippocampus does not, supporting the possibility that both NMDA and iron need to be elevated for the full neurotoxic effect to manifest. The globus pallidus, on the other hand, is an example of a structure that is less severely affected than the striatum, despite having higher iron concentrations6; however, this structure could be less susceptible because it has minimal NMDA enervation.41 In addition, cortex iron levels are highest in the deeper layers,42 which is where neurodegeneration is most noticeable in HD; NMDA enervation is more abundant in superficial cortical layers.43 Finally, the involvement of iron deposition in HD is also supported by the fact that the manifestation of HD is age-dependent, and with advancing age, brain iron levels increase.6,12 In the striatum, this age-related deposition progresses in a dorsoventral, mediolateral, and posteroanterior direction44 (G.B., unpublished observations, 1997), which is similar to the progression of HD neurotoxicity.45
Human studies have demonstrated mitochondrial defects in HD.34,38 Multiple animal models of HD use mitochondrial toxins that interfere with energy production.33,36,37,46 Reductions in oxidative phosphorylation tend to have a subcortical pattern of pathological development and induce age-dependent excitotoxic lesions with distribution similar to that of HD.33,46 Metabolic dysregulation of the mitochondria can result in increased free radical production36,38 and activation of NMDA receptors, which can magnify neurotoxicity46 at least in part through free radical mechanisms.33,39
The destructiveness of free radicals is greatly enhanced by the catalytic effects of iron.30 If huntingtin is primarily a metabolic dysregulator, more severe dysregulation may occur when the CAG repeat number is large, as occurs in juvenile-onset HD. In these young individuals, the toxicity may be dependent primarily on the presence of iron, which is deposited earlier and reaches higher levels in the globus pallidus and substantia nigra than in the rest of the extrapyramidal system.6 Dysregulation of iron metabolism in these structures has been implicated in the pathophysiology of Parkinson disease, which often manifests with rigidity, and rigidity is preponderant in patients with juvenile-onset HD as opposed to the choreoathetoid movements observed most often in those with adult-onset HD.
Consistent with a possible role for iron as a risk factor in oxidative neurotoxicity, one human treatment study suggested that early in the course of HD, antioxidant treatment may slow the rate of motor dysfunction.47 In vivo brain iron quantification could lead to new treatments of HD that might slow its course. The current findings were obtained in affected individuals, some of whom were early in their illness, and it may reasonably be hypothesized that a relationship exists between premorbid iron levels and the onset and/or rate of progression of symptoms of HD. If that supposition can be confirmed in prospective studies, new avenues of treatment and prevention of the disease would be possible (eg, iron lowering and/or antioxidant treatments). The treatment implications are especially relevant since iron chelator and antioxidant treatments are available, have been successfully used in other neurodegenerative disorders,48- 50 and, with appropriate precautions,51 could be evaluated for efficacy in patients with HD and preclinical HD. Genetic testing makes it possible to identify at-risk individuals long before the appearance of symptoms and provides the opportunity for very early intervention.
Our observation of increased basal ganglia iron levels early in the disease process does not necessarily indicate that increased brain iron levels are an etiology of HD. Even if they are not, one may hypothesize that reducing iron levels could still be an important therapeutic intervention, given the known neurotoxic effects of increased iron levels.30,52- 54 A clarifying analogy is Wilson disease, wherein it is therapeutically useful to treat an important factor of the pathogenesis (copper accumulation) while being unable to address the genetic etiology (defective ceruloplasmin).
Accepted for publication August 11, 1998.
This work was supported by a Department of Veterans Affairs Merit Review Grant (0016), Washington, DC, and the Marie Wilson Howells Endowment, Little Rock, Ark.
The authors acknowledge and thank Todd A. Tishler, BA, Jennifer A. Foster, BS, Ken Dery, BS, and Sun Sook Hwang, MS, for their assistance.
Reprints: George Bartzokis, MD, Central Arkansas Veterans Healthcare System (116A/NLR), 2200 Fort Roots Dr, Bldg 170, North Little Rock, AR 72114 (e-mail: email@example.com).


text:
Dispatch 2: Ready, willing, but unable
September 1, 2000
At 3:45 p.m. today the Northern Horizon
entered the Black Sea after completing the 17-mile [27-
kilometer] passage through the Bosporus Strait from
Istanbul. An hour later, Bob Ballard called the
expedition crew together below decks to outline the
teams mission and search strategy.
Weeks one and four the team will spend searching
shallow-water areas for early Paleolithic settlements,
Ballard said. Weeks two and three the team will search
deep-water regions for shipwrecks of antiquity believed
to lie along ancient trade routes.
Looking in the right placefor the right
cluesis key to the teams success. All who
were gathered knew that.
The right place in the case of Paleolithic settlements, Ballard estimates,
would be livable areas, regions with
broad stretches of flat land or river valleys and deltas.
To determine where those areas lie, Ballard explained,
we pulled the plug and drained the Black Sea to
what it was about 7,000 years agothen put the
plug back in.
The topography that emerges provides a number of clues.
Much of the old coastline is steep cliff. It can be ruled out.
The same is true for an area of beach. What remains are two prime
areas of broad, flat land that might have been settled by
Paleolithic peoples prior to the inundation of the Black
Sea basin.
Ballard announced the plan to start searching the first
target area around 6:00 p.m. The team would lower the
Woods Hole Oceanographic Institutes side-scan
sonar unit, the DSL-120, and begin collecting data. As
Ballard told the crew, Tonight well
either be confirming our thoughts or scratching our
The DSL-120 team prepped the unit and awaited the go-ahead.
But the O.K. never came. Monitors from the
Turkish government, traveling onboard the
Northern Horizon. denied permission for the
drop. The reason? The area lay outside the search zone
approved by the expedition teams research
The expedition team lost their chance to search a
prime piece of real estate, as Dwight
Coleman, an oceanographer from the Institute for
Exploration in Mystic, Connecticut, would say later.
It will take another 10 to 12 hours for the Northern
Horizon to reach its second target, a 150-square-
mile [390-square-kilometer] area found roughly 5 to 15
miles [8 to 24 kilometers] off the coast in the area of
Sinop. What was to be a busy night for team members
became instead time for equipment checks, rest, and
Sean Markey
Go to 1999 Dispatches
© 2000 National Geographic Society. All rights reserved.


text: Hi, PCBSD9.0-RC1-x64-DVD.iso; KDE; UFS (default). 1) System Settings --> Power Management --> General Settings. The button "Apply" (right-bottom) does not work; only works in the outgoing box. 2) Please replace /usr/local/share/doc/HTML/pl/konqueror/konkorg.png with its Eng variant. I think, the license permits to do this. The Windows user who will come to you, will feel oneself uncomfortable without antivirus. Perhaps it will be F-PROT as a good and well-known one. What to scare user for exploit? (See my Beta2 report: f-prot -> konqorg.png) 3) For your information. RKHUNTER generates "Warning" on the presence of hidden objects: the folder "/usr/.snap/" and file with a fork "/usr/.sujournal:data". Meanwhile, it isn't afraid of the analogues in "/" and "/var". Neither of these objects is allowed in config. Regards Serghey -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://lists.pcbsd.org/pipermail/testing/attachments/20111024/655136e1/attachment.html>


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Clarins Sunshine Fragrance
I really want to try this fragrance. It's said to have essential oils of Sicilian mandarin, grapefruit, bergamot, ylang ylang, Madagascar clove, patchouli, tonka bean, and osmanthus. I'm a huge citrus lover so that's right up my alley. It also contains griffonia seeds which are supposed to be mood boosters and its full of emollients and antioxidents.
Love the perfume, got it for my birthday, it's a very nice, soft, delicate fragrance...not too overwhelming which is perfect.Tags: fashion, gifts, beauty, accessories, style, luxe, designer, Marc Jacobs, perfumeAdded 6 Years Ago from Sephora
Kate Moss has a fragrance??? I'm sold.The fragrance has notes of vetiver, orange blossom absolute, magnolia, heliotrope, patchouli, peony, rose, musk and pink peppercorns.Added 9 Years Ago from Urban Outfitters
Much more than just a classic Waterford pattern, the "Lismore" fragrance radiates an enchanting floral aroma accented with patchouli, musk and vanilla. Quite the lass.Tags: fragrance, Eau de Parfum, Patchouli, Waterford, womens fragrances, dillards, Lismore, Waterford pattern, musk and vanillaAdded 9 Years Ago from Dillard's


text:
New Watford signing Mathias Ranegie believes he could be a perfect fit for the Championship and hopes that starting his football career late will allow him to play long into his thirties at Vicarage Road.
Ranegie, 29, finalised a move to the Hornets on a permanent deal from Udinese a fortnight ago having made only four appearances for the Italian side this season.
The 6ft 5in striker, who is known for his physical attributes and fearless attitude, believes his style of play could be ideal for the hard and fast nature of English football.
"I think I'm a player that fits in this league," said Ranegie, who has recently recovered from a hamstring strain.
"I do have that fearless side to my game. Even if you have a big body it doesn't make much of a difference if you're afraid. But I'm not afraid on the pitch.
"English clubs often play with big strikers – it's very common to have these kinds of players, especially in the Championship.
"Often the wingers have very good feet and they want to cross the ball into the box so I think I'll fit in very well here."
He added with a smile: "I don't want to only talk about my body – I'm not brainless, I can play with my head too – but I am a physical player."
Ranegie says he didn't start playing "serious football" until he was 22 when he signed for IFK Gothenburg but after an indifferent spell at the Swedish giants he made a name for himself at BK Häcken, where he scored 36 goals in 81 appearances.
Malmo signed him in 2011 and 13 goals in 26 games persuaded Udinese to sign the forward in August last summer.
Ranegie admits he sometimes wonders how far he could have gone had he started football earlier but he insists there are positives to be taken too.
"I've thought about it of course," he said.
"But starting late was probably good for my body too. I used to get injuries when I was a kid because I was so tall.
"I had problems with my knees and then I had a couple of years where I didn't play football so my body is maybe not like other 29 year olds.
"I think it's younger and I hope I might be able to go on longer as a result."
Ranegie, who says he was close to joining Blackpool and Middlesbrough a few years ago, nearly moved to Watford last summer but injuries to strikers at Udinese delayed the transfer.
He says he is well aware of the competitive nature of the Championship and is adamant Watford's promotion hopes are far from over.
Ranegie said: "There are so many classic teams in this division – almost every team has been in the Premier League so it's a beautiful league and I know it's very unpredictable.
"There's still that old English thing where some of the teams are big, some are small, some are teams who like to play football and some are physical and high tempo teams – but they can all win."
He continued: "The play-offs are still close. If anyone thinks we can't make the play-offs they don't understand football.
"There are so many games left and if you start winning, you can keep on winning. My dream here is to make a difference."
Ranegie had personal problems when he was young and a disenchantment with football, as well as injuries, contributed to his late arrival in football.
Religion helped the Swede steer his life back on track and he believes through football, God gave him a second chance.
"I found God and he saved me, he showed me how to live," he said. "I think talent is a blessing from a higher power and that it's something somebody gives you.
"I lost it and then I think God gave it back to me."
He continued: "There are so many football players who drop out from football when they're young and they think it's too late to pick it up again.
"I turned back to football when I was 22 and that shows if you have the talent you can do great things – talent is just the start."
Ranegie hopes his personal problems as a teenager don't influence Hornets supporters' perception of him now. He wants to be judged solely as a footballer.
When asked if he appreciates more what he has now because of his past, he joked: "I think I do but I have to be honest, I'm still like every other football player a lot of the time.
"Nobody can be humble all the time – I've been a football player for nine years now and sometimes, believe me, I forget.
"I know how I should probably answer this question but to be honest, I complain about the weather like everyone else."


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"She's been in a (shooting) slump lately, but she stepped up big tonight. She always scores in double figures and has an impact because she does everything else so well."
"You noticed that, too? We seem to go into shooting slumps. We were getting the good shots. We just had trouble making them."
"We seem to go in shooting slumps. It wasn't a surprise, but we knew we couldn't let it affect the whole game, the outcome of the game."
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R&P: Defensive Line paper thin? Inexperienced?
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Posted: Sat Aug 10, 2013 10:34 am
Post subject: R&P: Defensive Line paper thin? Inexperienced?
Heading into the season, two of the most important positional units that needed to be addressed was Secondary and Defensive Line. Dominik and Schiano really made the effort to improve the secondary, adding 2 All Pros in Revis and Goldson, and used our first draft pick in round 2 on big, lengthy physical playmaker Jonathon Banks.
The Defensive Line also had its struggles, especially since losing Clayborn and Bowers to injuries. Bowers returned and played a limited role last year and looked good coming off the injury. What I question about this unit? Is our depth too inexperienced?
At Defensive Tackle, we have a pro bowler and I believe All Pro in the making talent in Gerlad McCoy. His presence alone being back on this defense healthy, helped transform a 32nd ranked run defenise in 2011 to #1 in 2012. No question this guy is disruptive. However, he has had a past injury history that would make you want to be aware of and add some one who can play his position if he were to wear down and have an injury this year? From my eyes, Derek Landri, Gary Gibson, and Akeem Spence are more suited for the Tilted Nose position, leaving no one to come in and even spell McCoy some snaps. Even All Pro Geno Atkins didn't play nearly as many snaps as McCoy did last year and he had a double digit sack season. I don't like that the Bucs are experimenting kicking Bowers inside, who is not a true inside defensive tackle. To me, that is a terrible idea moving guys out of their natural position. I think the waiver wire/free agency, Bucs should be scouring the market for a DT. Richard Seymour would be a perfect addition as he can play both DT positions and strengthen our depth. I really like what Spence brings and he has upside as a pass rusher, but as you can see, he's a rookie who many should not expect to develop at a fast rate. I think that is what the Bucs are counting on. That's too much in my opinion. Gibson is a quality run stopper to rotate in as well. I think adding a guy like Seymour would only improve Gerlad McCoy's productivity.
At defensive end, there is talent there no doubt. But unprovent talent with injury risks. Adrian Clayborn is a guy I really like at DE. He's a man-child. Non stop motor, with a good blend of size, speed and strength. After his rookie year, I thought he just needed more development in pass rush moves and better supporting cast and he would be a 10+ sack guy. However a torn ACL in week 3 stunted that development. Going into his 3rd year, he looked even better shape. However a nagging Groin injury has kept him out. The only thing I;'m questioning Clayborn is can he stay healthy? If he can, he can be difficult to deal with at RDE. Bowers is about to take over Michael Bennett's position. Bowers throughout his career has not been a full time starter when healthy. He's s flashed his ability in a limited role. But can he take over for Michael Bennett full time?
Behind them? We have Daniel TeoNeisheim, who was solid and productive in a limited role. Steven Means and William Gholston, who have talent, but are again, rookies. Aaron Morgan is an undersized end, but has a lot of speed off the edge, but nothing to rave about. What I start to question now: for 5 million a year, why not re-sign Michael Bennett? Did he have a shoulder injury? Sure. But remember the saying, "you can never have enough pass rushers". Sure he had 9 sacks last year and his strength was against the run, but a DE rotation of Clayborn/Bowers/Bennett/Teo Neisheim while the rookies Means and Gholston Develop?
Again, Dom and Schiano are relying a lot of Rookies to step up. The only reason I'm questioning the dline, is , we haven't proven there is a mainstay of health there. Bennett played well last year with that nagging shoulder injury. Miller played well with a nagging knee injury. Bowers has looked horrendous and dissapointing in camp. Is he a starting LDE or is he a rotational guy?
These are very important questions that need answering. Because, quite frankly, we need improvement on the dline for our secondary to be successful.
Comments are welcomed. Thanks guys.
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Buc Ball
Joined: 09 Oct 2011
Posts: 3715
Posted: Sun Aug 11, 2013 2:03 pm
Post subject:
Great post RP!
I still can't get my head round the Bennett move, especially since he can play the 3 tech as well as the end postion. I understand that Schiano wanted to make Bowers feel like he was the guy, but he should be made to earn his spot as a starter.
I would really like bringing Seymour in based on how much he could benefit McCoy as a mentor- something McCoy talked about last week when he said he didn't really have a vet he could learn from when he first got here.
I think the best way to address the DT situation is to plan as if we won't have McCoy for an extended period. Who would play the 3 tech then? Right now, I don't think I want to know the answer.
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Joined: 31 Aug 2011
Posts: 11222
Posted: Sun Aug 11, 2013 4:11 pm
Post subject:
Now, after Bowers has been publicly pushed and challenged by the New Schiano Order, yesterday the defensive end admitted hes not yet adjusted to the pace of practice.
Bowers was asked to assess what he likes and doesnt like about his 2013 training camp performance.
I think Im still a little winded at times, Bowers said. Im not in the best shape, still getting used to the speed of practice. But other than that, (training camp) has been decent. I wasnt real happy with my game performance [against the Ravens.] A little banged up, no major injuries. But you know, Im ready to go. Just got to get better and grind.
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Joined: 21 Dec 2007
Posts: 14612
Location: Las Vegas
Posted: Sun Aug 11, 2013 4:49 pm
Post subject:
I still believe we should have brought in Abraham. First preseason game he got a sack and FF too....Biggest question mark on our team for sure
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This property has been removed by the agent. It may be let or temporarily removed from the market
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A 6 bay steel portal frame building with refrigerated store and drive on floor.
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Ethanol and biodiesel are two of the fuel options energy giant, Shell is looking at for the future and the firm is bringing some rigour to the investigation.
Shell claims to be the biggest biofuels distributor in the world, shifting around 3bn litres of bioethanol and other biofuels in 2005, equivalent to the total amount of gasoline consumed in the UK that year.
So where's Shell making its bets? Conversations at yesterday's press-only fuel open-day revolved around biofuels for sure, but the big thrust in the short term is into gas-to-liquids. This is a technology that can turn methane gas into diesel. Not as green as existing cracking processes, it uses more energy, but the fuel is distinctly cleaner, Shell says. The technology is not quite a cinch, but at 50 years old, (it was developed by the Germans during WW2) it is pretty well understood. Also diesel made this waycan be a direct, drop in replacement for conventionally refined diesel. So there are no worries about compatibility. There is no need to develop new engines to accommodate them.
Why gas-to-liquids and not groves of Jatropha, or fields of cassava as far as the eye can see? Because biofuels lovers,
Technorati Tags: biodiesel, bioethanol, biofuel, Companies, Corn, Europe, Jatropha, Second Generation, UK, Wheat, wood
existing sources of, natural gas, gasoline and diesel are going to be around for a long time yet, Shell says.
I can I hear you yelling, "they would say that, you oaf! They would."
Of course they would but, it's worth listening to them. Shell, and companies like Shell, are the gatekeepers to the one thing the biofuels industries will need: Customers. They have infrastructure to make and distribute fuels efficiently. The company also understands integration and the money to be made along a product chain from the well to the wheel. We can all learn from them. So, what are their criteria for biofuels to succeed? Paul Snaith, vice president downstream marketing, Shell Global Solutions saysbiofuel should only be used if they
1 Make Economic sense
2 Are socially and ecologically sustainable
3 Are technologically sound.
That makes a lot of sense to me. And should be taken on board by the biofuels industries, investors and people backing projects when they make their investment or policy decisions.
The day's focus in biofuels was on Shell's partnerships with in and Iogen. The recent hook up with Codexis was described as too long-range for Mondahy's discussions. I'm not a conspirasist, but I think that the ink dried on that deal too recently for the cautious employees of the cautious mollusc to talk too freely.
Both of these projects have one thing in common, they are pretty close to producing ethanol or biodiesel, said Lionel Clarke, technology manager, strategic research, fuels technology group at Shell Global Solutions.
The Iogen cooperation is likely to result in a 150,000 to 200,000 tonne/year bioethanol plant based around using corn stover from a catchment of about 50 square miles. This should be sustainable. No location was given for this, but the plant should be completed by the end of 2007.
Shell and Choven are likely to build a demonstration plant for to gassify woodchips and produce biofuels by the end of next year too.
Shell has decided to 'learn by doing' says Clarke. That I like. Not waiting to develop the ideal technical solution. Refine your answer as you go.
What else did I like about yesterday? Real clarity and honesty in one area, as Snaith said: Shell wants to make money from energy supply in the future and is trying to secure that future. It is placing bets in areas that could 'compete with gasoline and diesel' and it wants to operate 'areas that don't need to be propped up with subsidies.' Shell also highlighted the rich, long-term relationships that are needed with engine producers if they have developed. If there is one thing engine builders want it is a longterm relationship. No one night stands for them.
Its not fair to say that Shell is betting the farm on biofuels, because it isn't. We heard about hydrogen and GTL, but the firm is interested in ethanol and biodiesel and if an organisation this size is interested, then you'd be daft not to be yourself.


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The Telecommunications Policy Review Panel was established by the Minister of Industry on April 11, 2005, to conduct a review of Canada's telecommunications framework. The Panel was asked in particular to recommend on:
1. how to implement an efficient, fair, functional and forward-looking regulatory framework that serves Canadian consumers and businesses, and that can adapt to a changing technological landscape, 2. mechanisms to ensure that all Canadians continue to have an appropriate level of access to modern telecommunications services, 3. measures to promote the development, adoption and expanded use of advanced telecommunications services across the economy.
The Panel's reviewed Canada's telecommunications policy and regulatory framework and made recommendations on how to make it a model of 21st century regulation.
The Final Report of the Telecommunications Policy Review Panel 2006 is available here.
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Harriet Powers is one of the best-known southern African...
William Jay (ca. 1792-1837)
William Jay was an English-trained architect who, from 1817 to 1820, practiced in Savannah, where
Jay was born in 1792 or 1793 in Bath, England, to a family of stonemasons. From 1807 to 1813 he apprenticed in London with the architect David Riddall Roper, who built mostly in the Greek revival and Gothic revival styles. Jay's only known commission in London is the neoclassical-style Albion Chapel (1816), Moorgate, a square-shaped church with a recessed Ionic entry and a Pantheon-like dome.
In December 1817 Jay arrived in Savannah as the city's premier architect and one of the best-trained architects in America. The Owens-Thomas House (1819), a commission he received through a family connection, was the first of a series of neoclassical-style mansions Jay designed and features a Regency-style side porch supported by foliated consoles (leaf-shaped decorative brackets). The interior plans of the William Scarbrough House (1819), which later became the headquarters for the Historic Savannah Foundation, and the Alexander Telfair House (1819), which later became part of Telfair Museums, are configured in circular, oval, and elliptical shapes. In the Bulloch House (1818-19) Jay called for a dramatic spiral stair surrounded by Corinthian columns. Jay's last commission in Savannah was the Bank of the United States (1821), an early Greek revival–style
After returning to England in 1822, Jay produced designs for Pittville Parade, a large, six-unit row house. When the speculative Pittsville development failed in 1829, Jay went bankrupt and in 1836 was forced to accept the position of colonial architect and civil engineer on the island of Mauritius in the Indian Ocean east of Madagascar. Jay worked on the island until his death in 1837 in Port Louis, Mauritius.
Media Gallery: William Jay (ca. 1792-1837)
Further Reading
Hanna Hryniewiecka Lerski, William Jay: Itinerant English Architect, 1792-1837 (Lanham, Md.: University Press of America, 1983).
James Vernon McDonough, "William Jay, Regency Architect in Georgia and South Carolina" (Ph.D. diss., Princeton University, 1950).
James Vernon McDonough, "William Jay, Regency Architect in Georgia and South Carolina" (Ph.D. diss., Princeton University, 1950).
Cite This ArticleMoffson, Steven H. "William Jay (ca. 1792-1837)." New Georgia Encyclopedia. 25 October 2016. Web. 26 July 2017.
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From Our 2010 Archives
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The Inferno is the first third of Dante Alighieri's epic poem The Divine Comedy, originally written in the Tuscan dialect of Italian. It was written in the early years of the 14th century. In a time when all serious literary works invariably were written in Latin, Dante deliberately chose his native language to present his epic, hence the word comedy describing a subject that is far from light entertainment.
The poem was published in Italy a full century before Gutenberg's press revolutionized the printing and publishing industry. Although there are no known copies in Dante's hand that have survived to the present day, there are several hundred in manuscript form, some dating back to a few years after Dante's death. The first known copy to appear in print dates from 1472, over one hundred and fifty after Dante first published the work.
Larry Holzwarth is a freelance writer and submarine veteran. A former US Navy systems analyst, he has been a corporate writer on diverse subjects, a professional trainer, recruiter and lecturer.
A lifelong student of history, he enjoys reading, camping, hiking and Reds baseball. After traveling extensively he returned to his native midwest where he resides near Cincinnati.
The Inferno begins on the day before Good Friday in the year 1300, with Dante alone and lost in a dark forbidding forest, unable to find his way out. He is beset by a she-wolf, a lion and a leopard, unable to escape them he reaches the depths of despair and discouragement. At the end of hope, he encounters the ghost of the Roman poet Virgil, who claims to have been sent to Dante by Beatrice, who being in Paradise cannot descend to the depths where Dante must go.
Guided by Virgil, Dante enters the gates of hell. He descends through nine distinct concentric circles, each barred from the others, encountering many figures from both the recent past and antiquity. In each circle he finds the inhabitants condemned to spend eternity in the godless pursuits in which they spent their lives. His descriptions of eternal punishments and the sufferings of the punished are graphic in the extreme, yet laced at times with ironic and occasional bawdy humor.
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The SAU men's and women's track and field squads will look to build on their recent sweep of the Midwest Collegiate Conference meets at this weekend's NAIA Outdoor Track & Field National Championships in Marion, Ind.
The weekend marks the end of the road for two of the SAU's most accomplished athletes. Leading the Bees contingent to Indiana Wesleyan University for the meet which runs Thursday-Sunday are five-time All-American John Darmody and two-time All-American Mandy Streu. Darmody is wrapping up his most successful year to date as he was named Midwest Collegiate Conference Athlete of the Year for Cross Country, Indoor Track and Outdoor Track. He will be racing the 800 and 1,500 meter runs. Streu, one of just a handful of SAU student-athletes to ever earn two All-American titles, will also be competing in two events in her final meet. The recent grad will look to add to her hardware haul, competing in the shot put and the hammer throw. Wes Vaden will be making his first appearance at NAIA Outdoor Nationals after a 13th place finish in the shot put at this year's NAIA Indoor Nationals. Also competing for the Bees will be Ryan Buchanan and Morgan Meseke. Both Buchanan and Meseke will be racing in the Marathon Saturday morning.Coach Dan Tomlin was named men's and women's coach of the year as the Bees dominated the MCC meet earlier this month.
Sports links: View SAU Basketball Coach and Athletic Director Ray Shovlain's speech following his induction into the Quad Cities Sports Hall of Fame.
Read this Quad-City Times story about how senior Niki Green battled back from serious eye surgery to lead the SAU softball squad.
Read this Quad-City Times report on the Queen Bees Midwest Collegiate Conference championship game thriller.
Read about a record-setting SAU relay performance at the Drake Relays.
MORE LIKE THIS:AmbroseZine, Athletics, SAU in the News


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Details & Description
Help cheer your team towards the Super Bowl with the Women's Nike NFL Championship Drive 2.0 Tri-Blend T-Shirt. Signature Team logos grace the center of tee along with color-contrasting striping on the chest and arms for big style. The cozy tri-blend fabric keeps you warm, while the scoop neck and slim cut provides a flattering fit. Throw this tee on and help your team towards February.


text: Well, I personally have no reservations about sleeping on the floor - it's something you get used to as a guitarist. If I could have it my way, It would be just a fold out mat and a pillow, and maybe a blanket.. but it has come to my attention that my bed is very "difficult to sleep in." I dont have a boxspring, just a mattress on a crappy IKEA wooden frame, and a sheet and a comforter.. Anybody out there have a really sweet bed set-up they'd like to share? Thanks a lot.


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Definition of good
betterplay \ˈbe-tər\;
bestplay \ˈbest\
1a (1) : of a favorable character or tendency good news (2) : bountiful, fertile good land (3) : handsome, attractive good looksb (1) : suitable, fit good to eat (2) : free from injury or disease one good arm (3) : not depreciated bad money drives out good (4) : commercially sound a good risk (5) : that can be relied on good for another year good for a hundred dollars always good for a laugh (6) : profitable, advantageous made a very good dealc (1) : agreeable, pleasant had a good time (2) : salutary, wholesome good for a cold (3) : amusing, clever a good joked (1) : of a noticeably large size or quantity : considerable won by a good margin a good bit of the time (2) : full waited a good hour (3) —used as a word that gives force or emphasis to a statement a good many of use (1) : well-founded, cogent good reasons (2) : true holds good for society at large (3) : deserving of respect : honorable in good standing (4) : legally valid or effectual good titlef (1) : adequate, satisfactory good care —often used in faint praise his serve is only good — Frank Deford (2) : conforming to a standard good English (3) : liking only things that are of good quality : choice, discriminating good taste (4) : containing less fat and being less tender than higher grades —used of meat and especially of beef
2a (1) : virtuous, right, commendable a good person good conduct (2) : kind, benevolent good intentionsb : upper-class a good familyc : competent, skillful a good doctord (1) : loyal a good party man a good Catholic (2) : close a good friende : free from infirmity or sorrow I feel good
goodishplay \ˈgu̇-dish\ adjective
as good as
: in effect : virtually as good as dead
as good as gold
1 : of the highest worth or reliability his promise is as good as gold
2 : well-behaved the child was as good as gold
good vs. well
An old notion that it is wrong to say "I feel good" in reference to health still occasionally appears in print. The origins of this notion are obscure, but they seem to combine someone's idea that good should be reserved to describe virtue and uncertainty about whether an adverb or an adjective should follow feel. Today nearly everyone agrees that both good and well can be predicate adjectives after feel. Both are used to express good health, but good may connote good spirits in addition to good health.
Examples of good in a Sentence
You'll need better tools for this job.
The car is in good condition.
There are some good restaurants in this neighborhood.
I'm afraid your work is just not good enough.
Keep up the good work.
"Would you hire her again?" "Yes, I would. She does good work."
The food was good but not great.
He has done good but not outstanding work.
Did you have a good time at the party?
We're expecting good weather for the weekend.
Origin and Etymology of good
Middle English, from Old English gōd; akin to Old High German guot good, Middle High German gatern to unite, Sanskrit gadhya what one clings to
Definition of good
1a : something that is goodb (1) : something conforming to the moral order of the universe (2) : praiseworthy character : goodnessc : a good element or portion
2a : advancement of prosperity or well-being the good of the community it's for your own goodb : something useful or beneficial it's no good trying
3a : something that has economic utility or satisfies an economic wantb goods plural : personal property having intrinsic value but usually excluding money, securities, and negotiable instrumentsc goods plural : clothd goods plural : something manufactured or produced for sale : wares, merchandise canned goodse goods plural, British : freight
4 : good persons —used with the
5 goods plural a : the qualities required to achieve an endb : proof of wrongdoing didn't have the goods on him — T. G. Cooke
for goodor less commonly
for good and all
: forever, permanently She's gone for good.
in good with
: in a favored position with
to the good
1 : for the best : beneficial efforts to restrict credit were all to the good — Time
Examples of good in a Sentence
the battle of good versus evil
Teachers can be a strong force for good.
the difference between good and bad
They had to sacrifice lesser goods for greater ones.
What is life's highest good?
Parents must teach their children the difference between the good and the bad.
She believes that the good go to heaven when they die and the bad go to hell.
Only the good die young.
She believes there is some good in everyone.
Origin and Etymology of good
see 1good
Definition of good
1 : well he showed me how good I was doing — Herbert Gold
2 —used as an intensive a good long time
good vs. well
Adverbial good has been under attack from the schoolroom since the 19th century. Insistence on well rather than good has resulted in a split in connotation: well is standard, neutral, and colorless, while good is emotionally charged and emphatic. This makes good the adverb of choice in sports. "I'm seeing the ball real good" is what you hear — Roger Angell In such contexts as listen up. And listen good — Alex Karras lets fly with his tomatoes before they can flee. He gets Clarence good — Charles Dickinson good cannot be adequately replaced by well. Adverbial good is primarily a spoken form; in writing it occurs in reported and fictional speech and in generally familiar or informal contexts.
Examples of good in a Sentence
Things have been going good lately.
The team is doing good this year.
"How did you hit the ball today?" "Good."
The other team whipped us good.
Origin and Etymology of good
see 1good
First Known Use: 13th centurySee Words from the same year
GOOD Defined for English Language Learners
Definition of good for English Language Learners
: of high quality
: of somewhat high but not excellent quality
: correct or proper
Definition of good for English Language Learners
: morally good forces or influences
: something that is right or good
the good : the pleasant things that happen to people
Definition of good for English Language Learners
: completely and thoroughly
—used for emphasis before words like long and many
GOOD Defined for Kids
Definition of good for Students
1 : better than average good work
2 : skillful a good dancer
3 : behaving well a good child
5 : healthful Eat a good breakfast.
6 : of a favorable character or tendency good news
7 : suitable for a use : satisfactory You need good light for reading.
8 : desirable 1, attractive He's looking for a good job.
as good as
Definition of good for Students
2 : the good part of a person or thing I believe there is good in all of us.
3 : something right or good Good will come of this.
4 goods plural : products that are made for sale canned goods
5 goods plural : personal property He sold all his worldly goods.
Law Dictionary
Legal Definition of good
1 : commercially sound or reliable a good risk
2a : valid or effectual under the law b : free of defects
3a : characterized by honesty and fairness b : conforming to a standard of virtue shall hold their offices during good behavior — U.S. Constitution art. III; also : characterized by or relating to good behavior
Legal Definition of good
1 : advancement of prosperity and well-being for the good of the community
2 : an item of tangible movable personal property having value but usually excluding money, securities, and negotiable instruments —usually used in plural: as a pl : all things under section 2-103 of the Uniform Commercial Code that are movable at the time of identification to the contract for sale other than information, the money that is to be paid, investment securities, the subject matter of foreign exchange transactions, and choses in action b pl : all things under section 9-102 of the Uniform Commercial Code that are movable at the time that a security interest in them attaches or that are fixtures but excluding money, documents, instruments, accounts, chattel paper, general intangibles, commercial tort claims, deposit accounts, investment property, letter-of-credit rights, letters of credit, and minerals or the like before extraction consumer goods : goods purchased primarily for personal, family, or household uses durable goods : consumer goods that last and are used for a number of years : durables fungible goods : goods of which any unit is by nature or by usage of trade the equivalent of any other like unit especially as defined by section 1-201 of the Uniform Commercial Code future goods : goods that are the subject of a contract but are not yet existing or specified hard goods : durable goods in this entry household goods : goods used in connection with the home; specifically : furniture, furnishings, and personal effects used in a dwelling as defined by section 7-209 of the Uniform Commercial Code mobile goods : goods as formerly defined in section 9-103 of the Uniform Commercial Code that are mobile, are of a type (as vehicles) usually used in more than one jurisdiction, are not covered by a certificate of title, and are either the equipment of a debtor or inventory leased by a debtor ordinary goods : goods as formerly defined by section 9-103 of the Uniform Commercial Code that are anything other than those covered by a certificate of title, mobile goods, or minerals producer goods : goods (as tools and raw materials) used to produce other goods and satisfy human wants only indirectly soft goods : consumer goods that are not durable goods
Learn More about good
Thesaurus: All synonyms and antonyms for good Spanish Central: Translation of good Nglish: Translation of good for Spanish speakers Britannica English: Translation of good for Arabic speakers
Seen and Heard
What made you want to look up good? Please tell us where you read or heard it (including the quote, if possible).


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- Home
- Supersmile Whitening Toothpaste
Supersmile Whitening Toothpaste
We apologize for the inconvenience, but we are currently Sold out.
Available in: Original, Icy Mint, Mandarin Mint, Cinnamon, Green Apple.
It contains, in addition to cavity fighting fluoride, the proprietary supersmile ingredient, CALPROX©, proven to actually dissolve the protein pellicle—that clear, sticky film on teeth to which plaque and stains adhere—thereby effectively removing stains, even those caused by coffee, tea, tobacco and red wine, in as little as twelve days (when used properly on a dry toothbrush).
Moreover, it's 75% less abrasive than the permissible standard set by The American Dental Association guidelines—and completely safe and gentle for teeth and gums. Your teeth will feel and look noticeably smoother, cleaner and shinier from the very first use.
Supersmile Whitening Toothpaste comes in a 4.2 oz. Tube that lasts 3 months.
Dissolves the protein pellicle to which plaque, stain and bacteria attach without harmful bleaches or abrasives. Patented formula contains Calprox to whiten; baking soda for fresh breath and healthy gums; and ADA recommended fluoride to prevent cavities. Removes surface stains such as coffee, tea, tobacco, red wine, etc. 4.2oz tube lasts 3 months.
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- Whitens: Calprox® safely lifts surface stains such as coffee, tea, tobacco, red wine and other stains without harsh abrasives or the risk of sensitivity. Maintains and enhances the vibrancy of professionally bleached teeth. Restores bonding, caps, veneers and dentures to their original whiteness.
- Freshens: Sodium Bicarbonate provides long-lasting germicidal protection for fresher breath.
- Strengthens: The combination of Calcium, Phosphates and Magnesium re-mineralizes tooth enamel.
- Protects: Fights against cavities with fluoride.
- Silica Free, Gluten Free, Sulfate Free, Dye Free, Kosher. Contains Fluoride.
How It Works: Supersmile Toothpaste with Calprox® works by gently dissolving the protein pellicle - a thin layer of protein that forms on the tooth surface, and to which plaque, bacteria, and of course, stains adhere. Removing the protein pellicle leaves the teeth feeling cleaner for a longer period of time. Baking Soda provides long-lasting germicidal protection to ensure fresher breath and to prevent gum disease. Teeth are protected with Fluoride while the Calcium and Phosphates work to re-mineralize tooth enamel.
Since Supersmile Toothpaste contains no gritty silica - the abrasive ingredient commonly used in commercial toothpastes to scrape away the pellicle – it is 75% less abrasive than the recommended standard set by the American Dental Association.
Usage: For best results, place a pearl size drop of Whitening Toothpaste on a DRY toothbrush and brush in a circular motion for two minutes twice daily.
Active Ingredient: Sodium Monofluorophosphate (0.14% w/v Fluoride Ion) Aids in the prevention of dental cavities
Inactive ingredients: Water, Sorbitol, Dicalcium Phosphate Dihydrate, Sodium Bicarbonate, Calcium Carbonate, Titanium Dioxide, Cellulose Gum, Calprox®, Sodium Perborate, Flavor, Corn Starch, Magnesium Carbonate, Sodium Lauryl Sulfoacetate, Methyl Paraben, Sodium Saccharin, Propyl Paraben.


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At Newport Beach, CA, the long, straight shoreline separates the clear water (blue) from the sand (tan). Mitch, the lifeguard, is at M, 80 meters from the water, and sees a drowning child C, 120 meters from the sand. The points A and B are 280 meters apart along the shoreline. Mitch can run only 4 m/sec but he can swim 8 m/sec. At what spot on the shoreline AB should Mitch aim in order to reach the child at C as soon as possible? Compute the minimum time to the nearest tenth of a second; compare it to the times for the paths: MC, MAC, MBC.
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A child is drowning.
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It was a year ago, at Montreal's Metropolis club. The prominent indie rock band Broken Social Scene had just finished a show that saw the unforeseeable appearance of Andy Kim, the Rock Me Gently singer from another era. It was the former pop star's first live appearance in his hometown in four decades; for the occasion, BSS front man Kevin Drew invited the sexagenarian on stage to sing one of his old songs.
After the concert, Kim was leaving the building when he heard the lead-out music: Andy Kim's Greatest Hits. Kim stopped dead in his tracks when he heard it, and then spotted Drew walking away from the venue. Kim caught up to him, but, so appreciative of Drew's gesture to play his music, he was speechless. Drew, some 30 years his junior, smiled, telling him: "It's all good, Andy. It's all good."
Drew and Kim are close; the former helps the latter with his annual December charity concert, taking place Wednesday in Toronto. The song in Montreal that Kim had joined in with Broken Social Scene last winter was How'd We Ever Get This Way, Kim's first U.S. hit from 1968. And that's a good question: How did Drew and Kim, an interesting juxtaposition of pals, ever get that way?
"I don't know what it is," Kim says of his friendship with Drew. "I can't explain the connection – I just go with it.
We're sitting in Drew's condo in Toronto. Reminiscing about the Montreal concert, and Drew's decision to spotlight him, Kim is getting misty at the thought of it. "I don't know, man," he says, voice breaking. "It's a tough thing to digest."
At that, Drew steps in. "This is why I hang out with him," he explains. "You can get to the core of him. He lets you go there."
It's not usual that interview subjects break down, but it happens. I remember one musician becoming emotional speaking about basement-dwelling music bloggers tapping out mean-spirited reviews – petty criticism that could cut straight to an artist's heart. That interview was with Drew.
Drew and Kim, whatever their superficial differences, are musical romantics. Drew, who co-founded the leading Canadian independent label Arts & Crafts, "designs his world to his dreams," according to Kim. Drew last month announced that Broken Social Scene had played its "final show," a tour-ender in Rio de Janeiro. The star singer Feist, a part-time member of the collective, has gone on record to say that BSS would be back soon enough. Drew, currently writing with Kim, isn't sure about that. "We had 10 great years," he says of the band's run. "I felt like everyone was tired of it, although everybody obviously honours it."
As for Kim, as a 16-year-old upstart he adventurously moved to New York to work with Brill Building songwriting legends Leiber and Stoller, Jeff Barry and Carole King. Years later he still refers to the music industry as a "playground."
He's had up-times (co-writing the Archies 1969 mega-hit Sugar Sugar) and he's had down ones (pitching Rock Me Gently to DJs door-to-door because no one was interested in the song originally). Through it all, an almost childlike wonder radiates from him. "There's nothing in my life that's ever been anything other than 'Is this great or what?' " he says. "It's all magic to me."
Drew is drawn to Kim's upbeat nature. "To be taught to be grateful and to enjoy what you're doing, I think it's a daily practice in today's day and age," Drew says. "Our notions go toward what we don't have and what's not working and what's wrong."
This seventh-annual edition of the Andy Kim Christmas Show features its strongest bill yet, with guests to include Montreal rocker Sam Roberts, songbird Sarah Harmer, singer-songwriter Ron Sexsmith, the curious hip-hop artist Buck 65, guitarist Alex Lifeson of Rush, the charismatic Arkells, comedian Sean Cullen and members of Broken Social Scene and Finger Eleven. It takes place at the Phoenix Concert Theatre, a step up in venue size.
The cause is Julliette's Place, a shelter for abused women and their children. About attracting top-notch talent to perform and crowds to buy tickets, Kim prefers not to dissect the camaraderie. "Kindred spirits show up, and it's not for me to know why," he says. "I'm not smart enough to get it. But I'm smart enough to live it."
The Andy Kim Christmas Show takes place at Toronto's Phoenix Concert Theatre on Wednesday. For tickets, call 855-985-5000.Report Typo/Error
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Here's how you can download the Video Tube app free for your iPad, iPhone, iPad mini or iPod Touch.
1. Go to the Video Tube app preview page in iTunes (or tap the link on your iOS device to install the app directly).
2. Click the View in iTunes button.
3. Click the Free button to download the app.
4. Sync your iPad, iPhone, iPod Touch or iPad mini with iTunes to install the app.
Video Tube lets you access YouTube videos from your iOS device. It features a faster interface than the YouTube site, and contains a Favorites section. It will show automatic country specific content, and offers an easy video search, plus a history of videos that you've already watched.
This article is published as part of the IDG Contributor Network. Want to Join?


text: To get from Monterotondo a Misterbianco by train you can catch one of the 1 trains that everyday travel between Monterotondo-Mentana and Catania Acquicella, the closest station to the city. The first train to Catania Acquicella leaves from Monterotondo-Mentana at 10:47 and the last train departs at 10:47. If you choose a local train the trip lasts on average 20:31 hours. On Wanderio you can compare all schedules, fares and railway companies to Catania Acquicella and book the best itinerary starting from Monterotondo-Mentana.


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- Services
- We strive to provide complete care for our patients. Learn more about all the services we provide.
Lindenhurst Chiropractic Care
for Pain Relief and Wellness
We provide non-invasive pain management and whole body wellness, including chiropractic care, manual therapy, physical therapy, acupuncture and nutrition. We are a diverse team of experienced healthcare providers that work together to integrate health and wellness into your treatment. Located in Lindenhurst, we are proud to serve the Wadsworth, Antioch and Gurnee communities. Our chiropractor, Dr. Mark Freund, is an experienced provider of chiropractic care in Lindenhurst and has been helping patients break free from pain for over 15 years.
Natural Care Chiropractic
Helps Lindenhurst Patients Regain
Whole Body Wellness
If you have sustained an injury or suffer from chronic pain, you may feel frustrated with traditional medical treatment, which uses medication to cover up your pain, rather than helping you heal. We help our patients live pain free lives-without being dependent on medication. Our whole body approach to wellness uses natural, patient-proven treatments to help your body heal from within. These treatments include chiropractic, manual therapy and physical therapy. Our nutrition response testing can also help patients learn to eat for their body and promote healing.
Not only will Dr. Freund's care and whole body treatments relieve your current pain, but our treatment approach will also reduce the risk of future pain and illness. Our whole body approach to wellness means we evaluate not only your current pain symptoms, but also the underlying causes for pain and disruption in your body. Through adjustments, realignment and decompression, our chiropractor restores balance to your body and helps your muscles and joints heal themselves.
Patients choose us because our team is committed to helping you recover from injury and reach your potential - living well and feeling better, the natural way. We follow a diversified healing approach, believing that several non-invasive treatments, such as chiropractor adjustments, manual therapy and physical therapy, can work together to bring harmony to your body. We also support lifestyle changes and healthy nutrition to ensure all of your internal organs and body systems are optimized for ideal function.
If you are not familiar with chiropractor adjustments, manual therapy or physical therapy, you may have questions about these treatment methods. We invite you to explore the complimentary health and wellness articles available on our website. These articles and videos are an important resource for helping you learn about whole body wellness and the proven science behind our treatment techniques.
Dr. Freund and our care providers continue to participate in research and professional development, ensuring they provide our patients with the highest quality care and the latest proven treatment solution. Our team is proud to encourage healthy living through individual and community outreach to prevent injury and promote wellness.
Our Lindenhurst office is conveniently located near Wadsworth, Antioch and Gurnee. Appointments are available six days per week, Monday through Saturday. To schedule an appointment, please visit our appointment request page or call us at 847-265-0600. If you are struggling with chronic pain or simply seeking to 'be well', call us today. Our team is excited to be part of your wellness journey.
Lindenhurst Chiropractor | Natural Care Chiropractic | (847) 265-0600
2118 E. Grand Ave
Lindenhurst, IL 60046