text:
New insight into how neonatal exposure to DES affects uterus function in mice
By Robin Mackar
NIEHS in-house researchers are well known for their work on diethylstilbestrol (DES). Continuing in that tradition, a new study finds that mice exposed briefly to DES, a synthetic form of the female hormone estrogen, immediately after birth, had abnormal expression of the sine oculis homeobox 1 (Six1) gene in the uterus when they became adults.
The study, published in the October issue of Molecular Endocrinology, is the result of collaborative work between the Laboratory of Reproductive and Developmental Toxicology (LRDT) and the Laboratory of Molecular Carcinogenesis (LMC).
"DES exposure, just after birth, caused changes in specific epigenetic marks that regulate how genes are expressed in the uterus," said Carmen Williams, M.D., Ph.D., head of the LRDT Reproductive Medicine Group and lead researcher on the study. "Some of these epigenetic changes persisted long after exposure," Williams noted.
Epigenetic changes
Epigenetic changes mean that the underlying DNA sequence remains normal, but gene expression has been modified. In this case, the epigenetic changes were observed in a gene called Six1. Very little is known about how Six1 is regulated. "In humans the Six1 gene is associated with several types of cancers, including breast and cervix cancers," said Wendy Jefferson, Ph.D., a biologist in the Reproductive Medicine Group and first author on the paper.
DES was found to change the specific histone modifications that are associated with Six1 gene-regulatory regions functioning in the adult uterus. The particular histone modification changes found are typical of genes that are actively generating proteins. Persistence of the epigenetic changes probably explains why the Six1 protein is abnormally expressed in the uterus of older adult mice, when it normally is not there.
"These findings suggest that epigenetic changes, induced by early life exposures to estrogenic compounds, may explain the long-term effects of this exposure on fertility and the later development of cancer," Williams said.
As a follow up to these animal studies, the researchers are collaborating with Victoria Bae-Jump, M.D., Ph.D., and her colleagues at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center, to determine if Six1 expression is abnormal in the uterus of women with endometrial cancer.
DES was prescribed to millions of pregnant women between 1940 and 1971 to prevent miscarriage, premature deliveries, and other complications. Clinical studies found DES to be ineffective for these purposes and it is no longer prescribed. However, ongoing research by NIH and others continues to investigate the long-term health consequences associated with exposure to DES.
Citation: Jefferson WN, Chevalier DM, Phelps JY, Cantor AM, Padilla-Banks E, Newbold RR, Archer TK, Kinyamu HK, Williams CJ. 2013. Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure. Mol Endocrinol 27(10):1666-1677.
(Robin Mackar is the news director in the NIEHS Office of Communications and Public Liaison, and a frequent contributor to the Environmental Factor.)


text:
Managing inhouse databases incorporating images
Middleton, Michael R. (1993) Managing inhouse databases incorporating images. In Asian Pacific Specials Health and Law Librarians Conference, 23rd-26th August, 1993, Gold Coast, Queensland.
|PDF (45kB)
The utility of collections of data that combine text, images and other forms of information representation, is influenced by the capability of the associated information management system to support creation, classification, compression and storage, transport, and retrieval of information. Factors influencing the performance of these features are described with reference to in-house databases.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads:
Full-text downloads displays the total number of times this work's files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|ID Code:
|Item Type:
|Conference Paper
|Additional Information:
|Collected papers on CDROM
|Image databases, Information retrieval
|Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > LIBRARY AND INFORMATION STUDIES (080700) > Librarianship (080706)
Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > INFORMATION SYSTEMS (080600) > Database Management (080604)
|Past > QUT Faculties & Divisions > Faculty of Science and Technology
|Copyright Owner:
|Copyright 1993 (please consult author)
|Deposited On:
|16 May 2005 00:00
|Last Modified:
|09 Jun 2010 12:24
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page

subset: commoncrawl


text:
Ruth Page Foundation Records
The Newberry, Midwest Dance Collections
Established in Chicago by international dance icon Ruth Page in 1970, The Ruth Page Foundation is a 501(c) 3 private operating foundation committed to the education, promotion, and presentation of dance in Chicago. Emanating from the Illinois heartland, the visionary work of Ruth Page influenced the growth of theater design, opera ballet, and dance. She achieved worldwide recognition as a true pioneer of dance in America. Fellow would survey and appraise the Foundation's records, and might assist in transferring and processing the materials at the Newberry.


text:
330d clonks when clutch released and vibrates on idle
my 330d vibrates on idle and makes a annoying vibarating sound from in the dash, i am a mechanic and the engine is sweet as a nut pulls like a train etc and the problem is only on idle. also when i go to reverse it makes a donk/ clunking sound which it also does sometimes when i release the cluth when changing gear, i dont have much knowledge of rear wheel drives i work on vans. it sounds like there is play in something like a diff mount or the prop shaft but i havnt got a clue, is any of these issues something that you can help me with please? thanks, wayne.
sounds like the dual-mass flywheel, I believe the give away sign is that it rattles when turning off the car. Does this happen to you?
Thanks for your reply, i have read back through my post and i was'nt very clear, im sorry about that. the two things that i have asked about are not connected at all the vibrations that i have on idle is a seperate issue haha, i have the vibration at idle that i spoke of but also a seperate issue which is the clunking donking sound when reversing and changing gear, the clonking sound seems to be coming from the back end of the car to me, i can feel and hear it behind me as i am driving, if you you have any ideas as to what any of these issues could be i would really appreciate your input as i dont have any knowledge of rear wheel drives or bmw diesels eigther, i work on vans so any pointers would be appreciated, thanks
|All times are GMT -7. The time now is 06:50 AM.
Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2017, vBulletin Solutions, Inc.
© 2001- VerticalScope Inc. All rights reserved.


text:
USTA announced that it had fined Serena Williams $10,000 for a profane tirade. But that isn't the end of it.
Williams' tirade against a lineswoman who called her for a foot fault Saturday night in her semifinal match against Kim Clijsters may have gotten her into deeper trouble beyond the penalty point assessed that cost her the match. As taken from CBS replays of the tirade, Williams said at one point: "If I could, I would take this f---ing ball and shove it down your f---ing throat."


text:
POWELL-DNA-L ArchivesArchiver > POWELL-DNA > 2011-02 > 1298840769
Subject: Re: [POWELL-DNA] Reunion Software
Date: Sun, 27 Feb 2011 16:06:09 -0500
References: <firstname.lastname@example.com><firstname.lastname@example.com>
In-Reply-To: <email@example.com>
Reunion is compatible with OSX. But I am not sure what your EMac can do. Ask Apple. You can get the software from your local computer software store, or order it online at the Reunion web site.
-----Original Message-----
From: Rebba Workmon <>
To: Jim Barrett <>
Sent: Sat, Feb 26, 2011 11:15 pm
Subject: Re: [POWELL-DNA] Reunion Software
BarbaraWhere do you buy this Reunion software from. I have an EMac so can't use
just anything.
Rebba Workmon
> From:
> Date: Sat, 26 Feb 2011 13:50:34 -0500
> To: ;
> Subject: Re: [POWELL-DNA] Reunion Software
> I have used Reunion for over 20 years. Occasionally I have had the
> opportunity to try out other genealogy software programs, and none are
> near as easy to use and efficient as Reunion. You can store unlimited amount
> of notes for each person and program your reports the way you want them.
> Go for it. You will love it. Since I started with Reunion, I did not
> have to transfer a Gedcom in for my own family history. But I have entered
> gedcoms for other families from many different sources with no problem.
> They also have an online message board where you can ask whatever question you
> have about Reunion and also hardware problems.
> Barbara
> -------------------------------
> To unsubscribe from the list, please send an email to
with the word 'unsubscribe' without the quotes in the subject and the body of
the message
To unsubscribe from the list, please send an email to
with the word 'unsubscribe' without the quotes in the subject and the body of
the message
This thread:


text:
There was one of the most influencing, gorgeous and rich city states of the ancient world situated on a hill top (Acropolis) with an elevation of 392 meters from the sea level nearby a tiny beautiful Turkish town, Bergama, the modern town that derived its name from the ancient city, Pergamum (also spelled as Pergamon). The Attalos Dynasty who ruled the kingdom of Pergamum As from 283 BC up until 133 BC, ornamented this Acropolis with many magnificent structures creating a monumental city. Encircled with strong fortification walls which was providing an unshakable protection against the enemies, it was overlooking the plains below where the rivers Cetius and Selinus combine into Caicus river. The Area of the Acropolis was formed with several terraces enabling the construction of palaces, temples, altars, and many other structures. There was an everlasting fire burning in the Great Altar of Zeus, symbolizing the lively hood and prosperity of Pergamum.
Trajan Temple
History: We don't have much proof in our hands about the first settlement of the city, nothing belonging either the period of colonization between 12th and 10th centuries BC, or to the subsequent period of migrations, was discovered during excavations. Those who came during the period of migrations preferred to settle either on the offshore islands, or on peninsulas that could be defended easily. Since Pergamum was around 25 km. inland, it was not a favorable place for settlement.
It is known that the whole area came under the control of the Lydian King, Kroisos by 560 BC, who later defeated by the Persian King, Kyros. Persians divided Anatolia (Asiatic portion of today's Turkey) into four main administrative sections called "Satrapies"; Ionia, Hellespont, Clicia, and Lydia. During the Persian rule, Pergamum was completely free in its internal affairs but had to pay taxes and muster armies for Persian cause.
In 334 BC the King of Macedonia, Alexander the Great defeated the persian King Darius III on the banks of river Granicus. Thus, the control of the whole western Anatolia came under his rule. After the death of Alexander the Great in 323 BC, the huge empire was shared among his generals: Seleukos accepted Mesopotamia, Syria, and Eastern Anatolia; Kassandros received Macedonia, and Greece; Ptolemaios grasped Egypt and Libya; finally Lysimachus admitted to the possession of Southern and Western Anatolia including Pergamum.
Zeus Altar
Lysimachus turned the city into a military base and treasury for his share of 9000 talent gold coins which he entrusted to Philetairos, one of his much favored generals. Trying to constitute good relations with the other kingdoms, he married Arsinoe, the daughter of Ptolemaios and also arranged a marriage of his son to his sister-in-law. This peaceful period did not last very long. Philetairos betrayed Lysimachus who was defeated by Seleukos in 281 BC. After the death of Lysimachus, Philetairos became the king of Pergamum. He spent some of the treasury to restore the city walls and to reorganize his army. Establishing friendly relations with the neighboring countries he was able to enlarge the borders of his kingdom. After his uncle's death Eumenes I became the king of Pergamum in 263 BC. During his reign Pergamene kingdom expanded considerably, and treaties were signed with almost every city in Western Anatolia. During a war in the plain of Sardes the King of Syria, Antiochos was defeated, and killed by the Galatians on the way of escape. The Galatians who were settled in the close neighborhood, was threatening the kingdom, thus paying them tribute Pergamene succeeded in keeping them from attacking. During the time of Eumenes I (263-241 BC), Pergamum flourished as a center of arts and science competing with many other cities in Anatolia.
Eumenes I persuaded his successor, Attalos I to continue in his footsteps and left him a vast kingdom, a disciplined army and a rich treasury. Attalos I put an end to pay tributes to Galatians who in return attacked the territory of Pergamum to loot the city and punish the king. The morale of the Pergamene army was not high and strong as they were not receiving any help from the allied cities. In order to increase the morale of the soldiers, Attalos I resorted to a trick; he secretly wrote the word Nike (victory) on the liver of a sacrificed animal to foretell the result of the inevitable war. The trick yielded the boosted morale of the soldiers who attacked the Galatians and defeated them. After the victory over the Galatians, Attalos I gained a considerable amount of fame around the region. In the kingdom Syria, Seleukos II and his brother Antiochos Hierax was combating with each other for the throne, and Attalos I, benefiting from this situation, extended the borders of his kingdom up to Taurus mountains. Pergamene fought against the Galatians between 229-228 BC, and all of the confrontations resulted with the victory of pergamum, which was subsequently adorned with impressive monuments and the construction of famous Altar of Zeus begun.
The Age of Eumenes II : After his father's death, Eumenes II ascended the throne and pursued his father's policies establishing friendly relationships with Rome. During his period Eumenes II confronted with two important threats which he successfully overcome. First he defeated the Galatians re-organized and leaded by Ortiagon, and secondly with the help of Rome, Miletos, Erytra he managed to prevail over the army of Antiochus III, the king of Seleucids, who were sided with Ephesus, Tralles, and Telmassos. After his thirty-eight years of rule, Eumenes II died in 159 BC. His reign marked the history of Pergamum as the most powerful, and richest of all the times. He followed his father's foot steps and showed great success in the state affairs. Among his close friends was Pythias the historian, Menandros the philosopher, and many other scholars, poets, artists who contributed building of a prosperous, and strong city. The famous library and the altar of Zeus was built in this time. The Asklepeion was enlarged so that it could serve the patients from every city. Most of the monuments seen today was built during the reign of Eumenes II.
The Age of Attalos II : In 159 BC Eumenes II died and his brother Attalos II ascended the throne. He was quite effective in state affairs and well equipped with knowledge in military affairs. He had gained experience and talent from his brother and when his brother was alive he had received a proposal from Romans to become the king. But he stayed faitfull to his brother refusing this offer, thus receiving a title from his people "Attalos Philadelphos" (brother lover).
Maybe the most important works of Attalos II was the project of cleaning the harbor of Ephesus which was filled with the alluvium and silt deposited by the river kaystros. He also founded a city on the Mediterranean coast and gave his name to the city, Attaleia (today's Antalya)
The Age of Attalos III : After the death of Attalos II his nephew Attalos III became the king in 138 BC. He was not very much interested in state affairs but had great curiosity in biology, zoology, poisons, thus leaving the administration to the care of his trusted friends he indulged in doing experiments and research. In 133 BC he bequeathed the kingdom to Rome. His brother, Aristonikos strongly objected this decision and started a wide spread riot. Despite his several attempts to gain the power, Aristonikos was defeated and taken to Rome where he was brutally murdered.
Pergamum continued to be an important center during the Roman period. Emperor Augustus contributed the re-erection of the victory monuments of Pergamene Kings and completion of Trajan and Hadrian temple. Caracalla donated the restoration of Dionysos temple. During the Byzantine period pergamum was an important episcopal see and after the adoption of Christianity it became an important missionary center. Pergamum is one of the Seven Churches of the Revelation. "The place where satan has his altar" (Revelation 2,13) is believed to refer to the great Altar of Zeus.
The city sufferd very much from the attacks of the marauding Arabs, and sacked by them in 717 AD. Pergamum changed hands so frequently and controlled by Byzantines, Crusaders, Lascarid dynasty of Nicaea, and finally fell to Ottoman Sultan Orhan in 1336.
The Zeus Altar : the great Altar, dedicated to Zeus and Athena, was erected by Eumenes II for the commemoration of Pergamum's victory over the Celts by Attalos I. The Altar was constructed on a terrace 25 m lower down the south of Athena Temple, and this plan provided a harmonious unity. The frieze of the Altar was depicting the battle between the giants and the gods (Gigantomachy) symbolising the glory of order over chaos. There were also the depictions of Olympian gods and godesses like Leto, Artemis, Apollo, Helios, Poseidon, Amphitrite, Athena and Zeus. Today only the podium (crepidoma) is remaining in situ and hard to visualise the gorgeous altar since when it was discovered during a railroad construction around the region, by engineer, Carl Humann in 1871, it was taken to Germany in pieces and reconstructed and now in exhibiton in Pergamum museum in Berlin.
The Athena Temple : The remains of the temple are located on a large terrace above the thratre and Zeus altar. It was built during the reign of Philetairos in 4th C BC. It was 6X10 columns Doric order temple of andesite stone, and its Stylobate measures 12.72 x 21.77 meters. Athena was the major deith traditionally worshiped in the western Anatolia (the name given to Asiatic portion of today's Turkey). However the Athena temple in Pergamum was directly related to the Parthenon. After the triumphal battles against the Seleucids, Galatians (celts), and Macedonians, Eumenes II adorned the temple with two-storeyed staoas along the east and north sides. The temenos* of the Athena temple that was filled with many offerings, was entered through a monumental gate (four columned, two-storeyed Propylon), located on the east, Unfortunately only traces of of the foundations are now to be seen on the original site. Some fragments were restored and are now in the Berlin museum.
The Library : According to the famous historian, Strabon, the Library buiding was built during the reign of Eumnes II, and it was adjacent to the northern galary of the temenos of Athena Temple. The Library must have been built before the construction of the stoa of Athena temple, since the rooms of the Library did not have doors opening to the street or square, and was only entered through the upper storey of the north stoa. The largest room with wooden ceiling and used as reading lodge measured 13 by 16 meters, and housed the huge statue of Athena with the podium 4.5 meters high (now in Berlin museum). There were an air space between the shelves and the wall that helped to protect the precious volumes from damage by damp.
Ancient sources state there were around 200.000 volumes in the Pergamon library, however considering the capacity of the building as only 17.000 volumes, the rest should have been stored in other buildings in the vicinity. The growing fame of the Pergamum Library and the number and the quality of the volumes brought about the jeaolusy of the Egyptians who in return, ceased the export of Papyrus to Pergamum. The Pergamenes invented a paper from tretated animal skin, parchment which led the invention of paged books. The parchment derived its name from the word "Pergamon" and had so many advantages that in time they replaced scrolls.
The books of Pergamum library were transported to Alexandria as a gift from Antony to Cleopatra, and protected there until the 7th century AD. In 640 AD the whole collection was destroyed by the Arabs on the order of Caliph Omar who ruled that if the books in the library were in conformity with Koran, there was no need for them. If they involve material which disagreed with the koran, they should be destroyed.
Trajaneum (The Temple of Trajan) : The Trajan temple which was erected on a terrace measuring 68 by 58 m. carved from the hill was reflecting the characteristics of the Roman architectural styles. Due to space limitations on the hill top, the south part of the terrace was built on arched vaults and surrounded by a collonaded portico. The temple was built by Emperor Hadrian and dedicated to Emperor Trajan in the 2nd century AD. However both Emperors were worshipped here. The 6 by 9 columned, Korinthian order, Peripteros temple suffered much from several earthquakes and was in ruins. Restorations commenced in 1976.


text:
Games Plugin for PHP Melody - Retail
Category: Plugins/Modules
- views: 6256
- date: 12 November 2010
- posted by: aminex7
The plugin insert games from mochiads.
This is retail version
Works with: PHP Melody 1.6.1/1.6.2 / 1.6.3 / 1.6.4
Version 1.0.4 / May 15, 2010
the home page is here:
Moreover, in this way you can transform your website in an games arcade one. In one shoot ! By pressing one button, in only 5 minutes you can add thousands of games: along with the original description, tags, original width/height and even thumbnail. Worried about the extra server space ? This plugin needs only 100 kb on your server....none of the games or thumbnails will be stored on your server.
Download Games Plugin for PHP Melody - Retail
Download link Mirror1
Mirror2 Mirror3
Mirror4 Mirror5
Get 8.5% cashback
Related news:
|Members of GUESTS cannot leave comments.


text:
YOU couldn't blame Henning Berg for wondering what he has got himself into.
Just a few months ago he was enjoying earning a living as a pundit for Norwegian TV, now he is attempting to succeed in what, at times, looks like the impossible job.
Henning obviously thought life at Ewood Park would be smoother than it has turned out. He thought the squad was better than it is and believed the owners had learned from their mistakes.
Nine games in and he is already a man under pressure. Some supporters are questioning whether he is the man for the job and speculation is growing about his own mounting frustration.
Rumours about Berg's future are inevitable after the run Rovers are on at the moment. One win in nine games would put any manager under pressure.
Certain people in India are known to be growing increasingly twitchy about the situation as they start to fear an instant Premier League return is now not on the cards.
Failure to turn around Rovers fortunes before the New Year will almost certainly mean Rovers have to accept promotion is a no-go.
Some will say this means Berg has failed and needs to go and you can't help but feel Venky's might agree.
In a way they are right. He would have failed and not getting promoted will mean Venky's have to dig deep in their pockets to cover what will be massive financial losses.
Would any manager succeed in the current circumstances? You look at a number of factors and it is difficult to see how they would.
Firstly the squad has proved itself to simply be not good enough. I was among those who thought some of the summer signings would do well in the Championship but am the first to admit I was wrong.
The transfer window was a disaster in epic proportions. Out of the 12 players brought in, only striker Jordan Rhodes has proved a success.
Berg can't be blamed for that. That has to be down to Steve Kean and global advisor Shebby Singh.
The internal problems at Ewood Park have still not disappeared. There is conflict in the corridors of power and no one still has any real idea about who is running the club.
Was Berg the right appointment? At the time, it always looked a gamble with far more experienced candidates out there. But can you imagine Ian Holloway or Mick McCarthy working under Venky's? They wouldn't have lasted very long under the current regime.
Berg was the man given the responsibility to turn things around but he needs to be given the environment to stand a chance.
If he is going to fail, let him fail because of his own decisions and mistakes. Not other peoples.
It is very difficult to judge Henning at the moment as this isn't his squad and I think we all know the club is still a mess from top to bottom.
As for the Christmas party farce. Henning was spot on in refusing to dance on stage with a wig on his head. The person who asked him to should be looking at his own judgement.


text:
Visit a Branch!
You Can Do That @ the Library?!
Research Family History
At the Downtown Library, there's a genealogical section that will get you started and answer a lot of your questions. Can't make it in? Try our Genealogy Research Databases.
See our Calendar, Online Catalog or Branch pages for more details and contact information.
SCPL News & Announcements - Latest Posts
New ebooks added to Gale Virtual Reference
Our Gale Virtual Reference Library collection has been expanded! You can now peruse e-books on General Reference, Education, History, Nation and the World, Religion, Science, and Social Science by visiting the Downloadable Audio and Ebooks page and following the link to the Gale Virtual Reference Library. You can read the ebooks directly online, plus you have the option of selecting "listen" from any e-book to play an audio version!
Don't miss the extensive collection of travel books listed under General Reference. There are over 150 to choose from, covering countries all over the world.
View similarly tagged posts: Services
Posted by teeterj on May 22, 2012 at noon
Permalink: http://www.santacruzpl.org/news/permalink/97/


text:
The Perfect Gifts for the Cigar Lover: Cigars and Cigar Accessories
For the cigar aficionado or the novice, cigars make an excellent gift. If you have a friend or loved one that smokes cigars, it's now easier than ever to buy great cigars and cigar accessories with online retailers. Just about every brand and style of cigar you can think of are available online today - and at affordable prices. You don't have to leave the home or office to shop for a cigar gift that fits your budget.
The key is to find out what brand, flavor, length, and thickness your recipient enjoys. Perhaps they have one or two favorites. If you can find out what type of cigars they enjoy the most, this makes your shopping task much easier. If you have to guess at it, go with a popular mild brand with a medium size to be on the safe side. Or, you might give a cigar sampler gift instead of choosing one particular brand. A sampler will contain several cigars from various high-quality brands so your friend or loved one can enjoy sampling some of the top brands.
Cigar Gifts for Beginners
If your gift recipient is a beginner at smoking cigars, then you might consider buying cigars along with cigar accessories so they'll have all the items they need. There are humidor kits that contain a cigar humidor, a cigar cutter, a cigar ashtray, a tube, activator solution, and a cigar lighter. These make the perfect gifts because they contain many of the items needed to introduce a beginner to the world of cigar smoking. There are also elegant gift boxes for lighters such as the Vertigo Vader lighter series gift box.
If your friend already has many of the accessories needed, you might opt for a luxurious cigar humidor along with a set of their favorite cigars. One very nice humidor is the Master, which holds up to 75 cigars and is made with an elegant solid wood with a glass top. It is lined with scratch-resistant felt in the bottom and has wood with a deep mahogany color. Other elegant cigar humidors are Torino, Ebano Dome, Cordoba, Geneve, Medici, The Scottsdale, Treasure Dome, and The Estate. For a more elaborate cigar gift, there's the Coffee Table humidor with a solid wood construction, four top sectionals with beveled tempered glass, four Spanish cedar drawers with dividers, and other great features.
To find the perfect cigar gift, do a little research online to see what's available. Cigars come in various styles, which will determine the length and ring gauge (thickness) of the cigar. If you know your recipient enjoys long, relaxing smokes, then choose a cigar style that is longer with a large ring size. If they prefer quick smokes after meals, opt for shorter cigars. If you're not sure what they prefer, casually ask them about their cigars. Ask if they have a favorite brand and how long their cigars usually last while smoking.
Whatever cigar gift you choose, your friend, loved one, or client is sure to appreciate your thoughtfulness. Browse an online cigar store to find the brand and cigar accessories they will adore. Buying your cigar gift online will save time and money.
To learn more about subjects like cigar please visit the web site at: http://www.majon.com/directory
For more information and informative related articles and links about this subject matter and content, please visit Majon's Gifts | Gift Ideas | Gift Shops directory: http://www.majon.com/directory/gifts-gift-ideas-gift-shops.
About the Author
+Chris Robertson is a published author of Majon International. All Rights Reserved. Copyright 2014 (Fri Oct 10 2008) Majon International. Majon International is one of the worlds MOST popular internet marketing and internet advertising companies on the web. Visit their main business resource internet marketing web site at: http://www.majon.com


text:
Free Download Vellum WordPress Theme v.1.6.5 – ThemeForest | Vellum v1.6.5 – Responsive WordPress Theme is a new kind of Premium WP Template that comes with so much capability, you just have to see it. It is fully responsive and greatly SEO optimized web design. Vellum's unique structure lets you easily create any kind of web design, layout or style, all are come from a single theme. No matter the type of site you need, for eCommerce, photography, business, one page, real estate, travel, music or even ideal for a wedding. This professional theme does it all. This is not a single theme, it is a thousand themes in one.
Note: We want to improve our website's performance and usability so that you could really get a great benefit from our website. Just more one thing is that We publish all content only for testing purpose not for commercial use, so if you have money then we strongly recommend you to buy the require plugin/theme etc from original developer's website. Use any theme OR plugin on your own risk!
Download Links
- Super-ultra-mega responsive
- Parallax backgrounds
- Slider Revolution
- Traditional and modern blog styles
- Visual Composer content builder
- Mega-menus proudly powered by UberMenu (by SevenSpark)
- SEO optimized
- Post formats
- Sortable portfolio
- Post formats
- Drag and drop layout manager
- Blank page templates
- Unlimited home page variations
- Contact form builder
- Sidebar generator
- Unlimited headers
- Self-hosted HTML5 video player
- Unlimited footers
- Unbranded white label admin
- Unlimited layouts
- Unlimited color choices
- Google Fonts support (500+)
- Unlimited layouts and templates
- Custom audio player
- Retina ready
- Translation ready (.po/.mo files)
- Demo content included
- All Photoshop files included
- and so much more…


text:
The unit allows manual fan speed control (where the controlled HVAC plant allows for this). This can be
enabled or disabled using a configuration parameter during commissioning. The unit incorporates a 'Setback' or 'Economy Mode' feature which allows the unit to operate with a wider than normal temperature range around a Setpoint. This is usually used when the home or building is unoccupied. Setback allows energy saving, whilst maintaining a degree of comfort. The Setback feature is enabled or disabled via
a C-Bus Lighting Group Address. All thermostat control parameters are accessible via C-Bus, from the C-Bus Toolkit software. The unit responds to C-Bus HVAC application messages and broadcasts the
displayed temperature on C-Bus to enable other C-Bus devices to be able react to this information (eg, C-Bus Colour Touch Screen or Pascal Automation Controller).
laser.com | cbus-shop.com | laserknx.comCopyright © 2017 Laser Business Systems Ltd.
Use keywords to find the product you are looking for. Advanced Search


text:
|Home > National News > Article
Okay, time to lighten up again. Time to put that other September anniversary behind you and turn to remembering another significant, yet contrasting, event that occurred in the ninth month of the year.
As if to prove that Sydney's 2000 Olympic Games really were poles apart from their predecessors, nearly 500 poles of varying sizes have been planted to form an expansive wedge-shaped "forest" outside the Olympic stadium.
The multi-coloured poles, designed by architect Tony Caro, represent perhaps the ultimate Games tribute - each one a "vehicle portraying the history of the Games".
Games Memories, as it is somewhat unimaginatively called, may become the Olympic museum you have when you don't have an Olympic museum.
The poles include the names of the 74,000 Olympic and Paralympic volunteers on stainless-steel plaques, a tribute to Cathy Freeman, and "bolted-down" life-sized effigies of Fatso the Fat-Arsed Wombat and Kylie Minogue, in all her closing ceremony splendour.
The Fatso pole also features an audio-visual selection of the "juiciest" moments from The Dream, the nightly television program that was a hit during the Games for comedians Roy and H.G, Fatso's inventors.
The forest's centrepiece is a flying saucer-shaped canopy, in which visitors can watch a 40-minute package of highlights from the Games on 12 plasma screens. Mr Caro says the canopy was designed to create a sense of being in the "middle of the event".
He says his pole forest is an abstract reference to the number of visitors to Olympic Park during the height of the Games and he is interested to see how the new generation of Homebush Bay pilgrims relate to the concept.
Games Memories has been designed so that visitors can stroll through it in as little as five minutes, or as long as an hour.
It will provide a pre- or post-event activity for visitors to Olympic Park, and is expected to be an attraction for the increasing numbers of domestic and international tourists who visit Homebush Bay each week.
As for Fatso, who, in his Games Memories incarnation, comes complete with the shiny posterior that won him fame around the globe, Mr Caro is confident the model will not be a target for souvenir-hungry vandals.
"He'll be bolted down pretty tightly and he'll be up quite high," he says. "I suppose someone could get up on someone's shoulders, but they'd need a very big wrench. And, of course, there are plenty of security cameras located around that part of Olympic Park."
Games Memories will be launched by the Premier, Bob Carr, on Sunday, the second anniversary of the Olympics' opening ceremony.
The afternoon launch will be part of Sydney Olympic Park's Alive! festival.
Printer friendly version Email to a friend
Also in National
MPs to debate call to arms after Downer briefing
Sorry, there's not enough in the kitty for paid baby leave
Hard word on tuck shops to dump the junk
Jobs increase biggest in 11 years
Police drug dog raids leave bitter taste in clubs
Carr cashes up councils for crusade against urban eyesores
Silent majority: women kept quiet on sexual abuse
Advanced arthritis drug denied PBS listing
Growers get an ethanol booster shot
Surgery offers more hope after prostate cancer
The baby that never was
Schoolboy killed 'for mistaking party venue'
Volunteer's arrest over bushfires
Rulers of long paddock submit to ballot box
Brains vs brawn: the schools which think the choice is so passe
|text | handheld (how to)
membership |
conditions |
Copyright © 2002. The Sydney Morning Herald.
|advertise | contact us


text:
DR Strings BKB-50 Black Beauty Heavy Bass Strings
Sku #472480000000000
DR Strings
.050 Gauge Electric Bass Guitar Strings
- Write a Review
45 day price guarantee, 45 day return policy, 100% secure shopping
Advanced black coating for EXTRA-Life and Protection.
Extra-Life Black Beauty strings offer bass players a superior black coated string without sacrificing the crisp tone, clarity, and volume of traditional DR handmade strings. Extra-Life has a super thin advanced .0003" Black coating on the plain strings and on the wrap wire.


text:
Hello there envato staff and fellow composers, I have made something special for you guys to hear… I think you will laugh a little.
Here it is :http://www.youtube.com/watch?v=coT3Owzql7I&feature=youtu.be
Hope this brings a smile on your face.
Happy composing and let me know if you ever thought of this.
LOL, but awesome!
That is the most demented thing I've heard all day! Very funny.
Hahaha awesome!
Lmao! Were you bored by any chance?
"This submission does not meet our general commercial composition/arrangement standard, unfortunately."
Thanks for the morning laugh!
Hahaha! Totally crazy but made me laugh! Just what the world needs Maybe for fun we could set up a forum where people could create their own "Audio Jungle" remixes using the watermark (obviously not to sell hahaha!)
You nutter Careful though, somebody might use it by editing around the watermark!


text:
I am going to against ya all w/ Lou. I am frustrated w/ the team and ready to take a break like tk. But, I thought Lou tonite realized he was not shooting good, played point guard, and drove the ball to get the Hornets into the penalty. Not a great game but he adjusted UNLIKE most others on the team.
I am sick of Reggie and Sammy. Yes, both. Reggie can't shoot a layup or foul shots, does positive things but costs us too many easy points.
Glad they are not playing at home for a while since I am stuck w/ tickets. Even have an extra 10 that need to be used by eos (not the good teams are allowed, of course).
Sorry, just frustrated.
Brian, I would like a post about what to do this summer. I think next year could be a good year IF they get rid of Sam, sign Miller (or an equal point guard) and get a good 3 pt shooter. Your thoughts??
Btw, great job Mike.
He's shooting less, I'll give him that. But the decision making is just so poor. You learn when you're 7 not to leave your feet unless you know what you're going to do with the ball. He does it time and time again.
I think what we'll do either later in the season, or maybe when the season is over, is open the blog up. Let all the regulars submit their plan for what they'd like the Sixers to do this summer. Maybe we'll make a contest out of it.
Again, great job Mike.
i picked an odd time to call out Lou, because he really didn't play too badly tonight. but if he had just made 1 or 2 of those jumpers tonight, it's a whole new ballgame. i'm just very frustrated.
Hornets shot 4-of-5 on 3-pointers in the fourth quarter and 4-for-14 from inside the arc. Too many open 3s by good perimeter shooters were the difference.
A familiar theme.
I give up. Watching CSN at 1 am, after game interview w/ Willie Green, "We are playing at a high level.....".
W. Green G 24:00 3-12 1-5 0-0 -10 0 3 2 0 0 0 0 2 7
That is a good box score Willie? 25% regular shooting, 20% from 3?????
WHAT AM I MISSING, GUYS? What game is he playing? Maybe that is the problem????? FRUSTRATING!!!!!
A high level of what? Maybe by we he meant the Andres.
ugh that is maddening
he said "WE"


text:
|feedback | low graphics version
|You are in: Other Sports
Saturday, 10 March, 2001, 23:23 GMT
Steelers Eye Grand Slam
By BBC Sport Online's Stuart Hughes
Ayr Scottish Eagles 2-4 Sheffield Steelers
Sheffield Steelers lifted the Challenge Cup for the third successive year to leave themselves with one more hurdle to complete the Grand Slam.
At the Odyssey Arena in Belfast they added the Challenge Cup to their Benson and Hedges Cup and Superleague victories.
The participation of the South Yorkshire side had been in doubt less than 48 hours earlier because of a dispute over wage payments.
But as they have done so often this season, the Steelers put their off-ice difficulties aside.
The Eagles, the only other team to win four titles in a season, took advantage of a free-flowing start to the game.
Ironically it was Ed Courtenay - voted Superleague player of the year last season with the Steelers - who put Ayr ahead after three and a half minutes.
Sheffield steadied themselves after the early shock and equalised with 8:23 remaining in the opening period.
Defenceman Steve Carpenter picked up a feed from Warren Norris at the top of the circle and sent the puck through Philippe De Rouville's five-hole with a powerful one-timer.
Sheffield continued to squeeze the Eagles and took the lead in the 18th minute. Warren Norris found himself all alone in front of the net and had all the time in the world to convert.
Late drama
Despite being out-shot 11-3 in the opening session, the Eagles refused to be intimidated.
British ice hockey's all-time leading points scorer, Tony Hand, drew the Scottish franchise level on the power play at 24:03 and almost put the Eagles ahead shortly after.
Referee Moray Hanson waved the goal off because Ed Courtenay was inside the crease.
Ayr's hopes of a comeback were short-lived, though.
At 26:43 David Longstaff pounced on a loose puck and sent it to Paul Beraldo in the slot, who made no mistake.
Rick Brebant secured Sheffield's third piece of silverware this season with a strike at 45:46, leaving the Steelers with the play-off title firmly in their sights to crown an outstanding season.
Sheffield coach Mike Blaisdell paid tribute to the Eagles' performance.
"I thought Ayr played very hard. They played with a lot of heart and passion tonight and it was a difficult game for us," he said.
"I knew they'd want to protect the Grand Slam but the guys did a great job," he added.
In Saturday's play-off games, London Knights got their defence of the title off to the best possible start with a 2-1 victory over Nottingham Panthers.
Bracknell Bees overcame Manchester Storm 3-1 in the opening game in Group B.
See also:
09 Mar 01 | Northern Ireland
Challenge Cup fears eased
08 Mar 01 | Northern Ireland
Sheffield edge out Giants
Internet links:
The BBC is not responsible for the content of external internet sites
Other top Other Sports stories:
Links to top Other Sports stories are at the foot of the page.
Links to other Other Sports stories
|^^ Back to top
|Front Page | Football | Cricket | Rugby Union | Rugby League | Tennis | Golf | Motorsport | Boxing | Athletics | Other Sports | Sports Talk |
In Depth | Photo Galleries | Audio/Video | TV & Radio | BBC Pundits | Question of Sport | Funny Old Game
BBC News >> | BBC Weather >>
© MMII | News Sources | Privacy


text:
Here at Bigfish Screenprinting we specialize in building customer relationships via top notch customer service, creatively talented artists and detail oriented printers through high end screen printing, embroidery, and promotional products. Our mission is to streamline your order and create a product that Bigfish Screenprinting and you, our client, are proud to show off. You can rest assured that you are receiving unmatched service. Our experience in the industry has shown us that this is not always the case. From lost orders to clip art designs on 'giveaway' quality tees. Seeing these things have driven us to think outside the box and revolutionize your order with things you didn't even imagine! In perfecting our process, we have developed our own line of clothing to test out new ink techniques and printing methods called Fish Apparel.
Bigfish is surrounded with professionals that continue to think outside the box to fulfill every client's needs. We are known as a one-stop shop for anything our clients need in the textile decoration and/or promotional products industry. We take our clients' visions and turn them into reality.
The Bigfish Screenprinting Difference?
As a small business, in a select market, we hear the question all the time; "What makes you different?" We have heard it so much that we decided to give it a label of: "The Bigfish Difference". While some small businesses may break out in a sweat or hesitate when confronted with a question of this nature, here at Bigfish Screenprinting we are confident in our answer. Differentiation is what makes US memorable to a potential customer to quickly understand what sets apart. From unmatched customer service to always on time completion dates.
Some small businesses will flock to the phrase; "We will beat anyone's price!" But how many times do you find yourself in a 1 star hotel instead of paying a bit more for a 4 or 5 star hotel? You get what you pay for is a statement that is based on reality, but to many times we ignore this and think it will be better for me. In some cases this works out, however far too often the situation puts you in need.
At Bigfish Screenprinting we are in it for your trust, not the invoice. Trust is one of the biggest parts of a growing relationship and that's what we want to make with you. Trust means that you have placed your confidence and faith in your partnership, and that you expect honesty, loyalty, respect, and integrity to be at the center of that relationship. We want to continue to gain your trust.
So come see why we say, "Experience the Bigfish Difference!"
The following quote describes the attitude we strive to attain here at Bigfish Screenprinting:
"A customer is the most important visitor on our premises. He is not dependent on us. We are dependent on him. He is not an interruption in our work. He is the purpose of it. He is not an outsider in our business. He is part of it. We are not doing him a favor by serving him. He is doing us a favor by giving us an opportunity to do so." ― Kenneth B. Elliott


text:
8 Recommendations
kurtrik's recommendation
a simple, minimalist watch that draws compliments. now with a light! unisex.
glasgowwestie's recommendation
Don't go for brushed or polished steel - the only one to have is the limited edition with black metal and black strap. Mainly found in Hong Kong.
XzanderX's recommendation
I bought one last month. It looks great on my arm. And the best thing is, that it's ultra light so I can barely feel it on my arm!
My Collections:
ShopGuy's recommendation
I just received this as a present and didn't know the site, now I am completely hooked and will definitely do my holiday shopping there. I have a black version which I didn't find, but it's a very nice watch, it has a subtle blue light and that's pretty much it, no gimmicks, just very light and thin, absolutely beautiful.
scottsykora's recommendation
I love the simplicity and style that you can never find in a digital watch. The black is nice too.
KGB's recommendation
This watch has the nice, chic, simple design I am always looking for in timepieces. It is very casually with its canvas strap and simple electronic watch face. fashion
vjk9964's recommendation
I have always wanted an uber simple watch that just told time... no frills necessary.. I like this a lot because of its style and simplicity.
My Collections:
arcticwarbler's recommendation
It was ok. I returned it.
My Collections:


text:
ROME (Jul. 17)
A Socialist-Liberal clash over Italy's attitudes toward President Nasser of the United Arab Republic and the American intervention in Lebanon marked the Parliamentary debate today preceding the confidence vote in the new government of Amintore Fanfani.
Pietro Nenni, leader of the Socialist party, asked the new government to take a "firm stand" on the Mid-east situation, declaring that the Arab liberation movement was an "inevitable historical reality" which could be "disciplined but not avoided." Mr. Nenni urged a conference of all interested nations and said he disliked "obsolete kings and fanatical colonels" but insisted that the West should have given Nasser more chances to develop his "neutralist policy."
Praising Premier Fanfani's 1956 statements against the Suez intervention, Nenni urged a three-point Italian foreign policy program based on disapproval of American intervention not endorsed by the United Nations, an Italian bid for UN Middle East debate before "new accomplished facts developed," and an Italian program aimed at conciliating both sides without military participation on any side. He added that the Atlantic Pact left Italy free to exercise an initiative in the Middle East of which, he said, the new government should take "fruitful advantage."
Franesco Malagodi, Liberal Party leader, expressed solidarity with the current action of western countries in the Middle East crisis. He asked Premier Fanfani to declare whether after "present developments," the formal invitation to Nasser to visit Italy was still standing.


text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
RNA-based approaches are among the most promising strategies aimed at developing safer and more effective therapeutics. RNA therapeutics include small non-coding miRNAs, small interfering RNA, RNA aptamers and more recently, small activating RNAs. However, major barriers exist to the use of RNAs as therapeutics such as resistance to nucleases present in biological fluids, poor chemical stability, need of specific cell targeted delivery and easy entry into the cell. Such issues have been addressed by several recent reports that show the possibility of introducing chemical modifications in small RNAs to stabilize the molecular conformation and increase by several fold their integrity, while still preserving the functional activity. Further, several aptamers have been developed as excellent candidates for the specific recognition of cell surface targets. In the last few years, by taking advantage of recent advances in the small RNA field, molecular bioconjugates have been designed that permit specific targeting and may act as cargoes for cell internalization of small RNAs acting on gene expression that will be discussed in this review.
Innovative targeted therapeutic strategies aim at developing new molecules with high target affinity and specificity with suitable pharmacokinetic properties for
Several classes of molecules have been characterized with potential applications as RNA therapeutics in the treatment of human diseases. These include ribozymes, RNA decoys, aptamers, small interfering RNA (siRNA) and microRNA (miRNA) [
The discovery of RNA-mediated interference (RNAi) for gene silencing has provided a powerful tool for loss-of-function studies and therapeutic opportunities [
As a difference with siRNAs and miRNAs, the function of ribozymes and aptamers doesn't involve the formation of the RISC. The hammerhead small ribozymes are nucleolytic oligonucleotides that recognize and excise a given target RNA molecule [
Recognition by toll-like receptors (TLRs) in immune cells represents a major obstacle to the use of RNA-based therapeutics. However, immune recognition the immune response of single stranded siRNAs (ss-siRNA) or ds-siRNAs by TLRs can be bypassed by the replacement of only uridines with their 2′-fluoro, 2′-deoxy, or 2′-
A major impediment to the clinical development of RNA drugs is the lack of an appropriate and high efficiency
Currently, the list of oligonucleotides of therapeutic interest is growing rapidly with over one hundred clinical trials and two therapeutic oligonucleotides that have been already approved by U.S. Food and Drug Administration (FDA) and marketed, the Vitravene antisense antiviral and the Macugen RNA-based aptamer. Two classes of therapeutic oligonucleotides have predominantly been developed: siRNA and aptamers, and several of them are currently in clinical trials (
Recently, the use of RNAi-based gene silencing has been demonstrated in humans for treatment of several diseases, as discussed in multiple recent reviews [
Various clinical studies have explored the direct tissue delivery of siRNA into the eye for macular degeneration in humans. Among the growth factors implicated in the age-related macular degeneration (AMD) process, the vascular endothelial growth factor (VEGF) has been shown to be a major inducer of choroidal neovascularization [
Silencing of gene expression by RNAi has been extensively studied to develop innovative cancer therapeutic strategies. Indeed, many of the siRNAs are in different stages of development for the treatment of different kind of tumors. For examples, among the siRNA therapeutics for the treatment of solid tumors, CALAA-01 and Atu027, targeting the M2 subunit of ribonucleotide reductase and protein kinase N3, respectively, are in Phase I, whereas, FANG against Furin is in Phase II. Further, SPC2996 against BCL-2 is in Phase II for treatment of chronic myeloid leukemia (from
In recent studies, given the strong impact of siRNAs for therapeutic applications, a great effort is focused on the optimization of the efficacy of the siRNAs through relatively minor chemical and structural modifications to canonical siRNA. The final aim is to improve loading of the guide strand into the RNAi machinery and reduce off-target effects and competition with endogenous miRNAs.
The group of Rossi [
Aptamers are short single-stranded DNAs or RNAs that like antibodies, bind with high affinity to specific targets by folding into complex tertiary structures. They have some important advantages over antibodies and other protein-based reagents as therapeutics. A number of these advantages stem from the fact that aptamers are generated by an iterative
The list of aptamers against important therapeutic targets is growing rapidly and some of them have already entered the clinical pipeline (see
Many other aptamers, not yet approved by the FDA, are currently in clinical trials. For example other two aptamers, named E10030 and ARC1905, are in Phase II and I of clinical trials for the treatment of AMD, respectively. E10030 is a DNA-aptamer directed against the platelet-derived growth factor-B (PDGF-B) chemical modified with 2′-F-Py and 2′-OMe-Pu and PEG [
Furthermore, different aptamers targeting blood-clotting factors seems to be effective anticoagulant agents. The ARC1779 is a DNA-aptamer directed against the A1 domain of von Willebrand factor, currently in phase II clinical trials for the treatment of thrombotic microangiopathies (TMA) [
Particularly interesting is REG-1, an aptamer targeting the coagulation factor IXa. This is the first case of a modulator-controlled aptamer able to provide a time-controllable therapy. REG-1 is a two-part therapeutic agent, consisting of an RNA aptamer specific for the coagulation factor IXa (RB006) and a single stranded RNA oligonucleotide complementary to the RB006 aptamer (RB007). Aptamer inhibition of the factor IXa by RB006 is structurally disrupted by administration of the antidote complementary strand RB007. The REG-1 aptamer-antidote therapy has been tested in Phase I and II clinical trials with promising results as an anticoagulation therapy to prevent clot formation during cardiac surgery [
Moreover, different aptamers for cancer therapy are also in clinical trials. NOX-A12 is an L-RNA spiegelmer directed against the stromal cell-derived factor-1α (SDF-1α), a chemokine which attracts and activates immune and non-immune cells that bind to chemokine receptors CXCR4 and CXCR7. This aptamer is in Phase I clinical trials for the treatment of hematologic tumors. The AS1411 aptamer, instead, showed effectiveness for the treatment of acute myeloid leukaemia (AML) in phase I and II clinical trials. AS1411 is a DNA-aptamer, directed against nucleolin [
Apart from the aptamers mentioned above, many other aptamers are not yet developed in clinic but target molecules of high therapeutic interest thus appearing as excellent drug candidates for a wide range of human pathologies [
Although the clinical development of miRNAs has not yet been realized, they are attractive candidates as prognostic biomarkers and therapeutic targets in different diseases including cardiovascular disease and cancer. In addition, the use of complementary antisense oligonucleotides has been developed for miRNA silencing in research and therapy. Antisense inhibitors act by competing for miRNA binding to the proper sites on target mRNAs and include small synthetic RNAs, antagomir, and modified RNA oligonucleotides, as locked nucleic acid (LNA) [
Cardiovascular disease is the leading cause of death in industrialized nations. Several miRNAs have been recently implicated in cardiomyocyte hypertrophy, increased fibrosis and apoptosis during heart failure [
Expression of several miRNAs has been shown to be deregulated in many cancer types. Further, based on their involvement in basic cellular functions, miRNAs may act as oncogenes (oncomirs) or tumor suppressor as critical players in cell transformation [
For example, it has been demonstrated that the let-7 family contains miRNAs regulating the RAS family of oncogenes [
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, thus efficient delivery strategies remains the main challenge for their clinical development [
In this respect a promising application of aptamers is to use them to deliver a variety of secondary reagents, including therapeutic siRNAs, specifically to a targeted cell population (
This means that aptamers function as specific recognition ligands to target cells, which is especially significant given the whole cell-SELEX strategy to target specifically cell surface epitopes [
The cell-SELEX method allows for the generation of aptamers against cell surface targets by replicating the native conformation and glycosylation pattern of the extracellular regions of proteins. Recently, multiple groups have reported selections using living cells as the target to identify receptor-specific aptamers and those that bind to a specific cell type [
In the aptamer-based delivery approach, the last goal is to develop an aptamer to the extracellular portion of such a protein and then use the aptamer to deliver the secondary reagent to the targeted cell population via binding the targeted protein on the surface of the targeted cell type. Because this binding in some cases also results in the endocytosis of the aptamer/secondary reagent complex, this approach can be used to deliver reagents such as siRNAs that depend on delivery to intracellular compartments for their proper function (
To date, the best-characterized aptamers for targeted delivery are the two 2′-F-Py-RNA aptamers (A9 and A10) that have been generated against the extracellular domain of the prostate-specific membrane antigen (PSMA) [
A first study reports the non-covalent conjugation of siRNA with A9 aptamer via a streptavidin connector [
In the same year, McNamara
In addition, the PSMA-siRNA chimeric molecule has been further modified for
To date several groups have adapted the covalent assembly approach to aptamer-mediated siRNA delivery [
Rossi and colleagues have extensively characterized the HIV glycoprotein gp120 as a target for aptamer-mediated siRNA delivery [
With the development of the conjugation strategies, the list of aptamers against surface epitopes that are being used as delivery agents is growing rapidly and now includes those against PTK7 [
Even if only one nucleic acid aptamer has been approved and is on the market, aptamers hold an extraordinary potential in drug development and it is plausible that the global interest for their development will increase in the next few years. Accordingly, a new technical market research report, from BCC Research [
To date, Archemix Corp. is a leading biopharmaceutical company in the development of aptamers as therapeutics. It is the owner of the aptamer technology patent and it collaborates with other pharmaceutical companies (Regado, Antisoma, ARCA Biopharma and Ophthotech) to develop and commercialize a pipeline of partnered aptamers in the cardiovascular disease, hematology and oncology areas.
Moreover, the development of aptamers as delivery agents for therapeutic RNAs can have a considerable impact on aptamer market in the near future. Indeed, intracellular delivery has been a key challenge for RNA modalities and the potential of bringing together the properties of aptamers and microRNA therapeutics will allow to overcome this limitation and open further potential for RNA-based therapeutics.
Recently Archemix Corp. started a collaboration with miRagen Therapeutics Inc., a biopharmaceutical company focused on developing innovative microRNA-based therapeutics for cardiovascular and muscle disease, for the development of conjugated aptamer-microRNA molecules capable of intracellular delivery and subsequent microRNA targeting. Combining aptamers and microRNA therapeutics has the potential to solve the intracellular delivery challenge for certain RNA-based therapeutic approaches. In this perspective, even if aptamer-miRNA chimeras have not been already described in literature, it is plausible that the approaches discussed in this review for aptamer-siRNA conjugation could be as well adapted to generate aptamer-miRNA molecules of fundamental therapeutic value.
Aptamers as delivery agents. Aptamers that bind to cell surface receptors can be used to deliver siRNA to target cells.
Anti-PSMA aptamer-siRNA chimeras. (
siRNAs and aptamers in clinical trials.
|Pachyonychia Congenita Project
|Keratin 6A N171K mutant
|Pachyonychia congenita
|Phase I
|Quark Pharmaceuticals
|Caspase 2
|Non-arteritic anterior ischaemic optic neuropathy
|Phase I
|Sirna Therapeutics
|AMD Choroidal neovascularization
|Phase II
|Diabetic macular oedema (DME), AMD
|Phase I
|β2 adrenergic receptor
|Phase II
|Familial adenomatous polyposis
|Phase I
|Alnyam Pharmaceuticals
|Liver tumours
|Phase I
|Solid tumours
|Phase II
|Calando Pharmaceuticals
|Solid tumours
|Phase I
|Santaris Pharm.
|Chronic myeloid leukaemia
|Phase II
|Alnylam Pharmaceuticals
|VEGF, kinesin spindle protein
|Solid tumours
|Phase I
|Duke University
|LMP2, LMP7, and MECL1
|Metastatic melanoma
|Phase I
|Silence Therapeutics
|Advanced, recurrent or metastatic solid malignancies
|Phase I
|Quark Pharmaceuticals
|Acute kidney injury
|Phase II
|Tekmira Pharmaceuticals Corp.
|Phase I
|Tekmira Pharmaceuticals Corp.
|Phase I
|Santaris Pharma
|Hepatitis C virus
|Phase II
|City of Hope Medical Center/Benitec
|HIV Tat protein, HIV TAR RNA, human CCR5
|Phase 0
|Alnylam Pharmaceuticals
|RSV nucleocapsid
|RSV in volunteers
|Phase II
|Macugen (Pegaptanib)
|Eyetech Pharmaceuticals/Pfitzer
|AMD Diabetc retinopathy
|Approved Phase III
|Ophthotech Corp./Archemix Corp.
|Phase II
|Ophthotech Corp./Archemix Corp.
|Phase I
|Archemix Corp.
|Phase II
|ARCA Biopharma/Archemix Corp.
|Acute coronary artery bypass surgery
|Phase II
|Regado Biosciences/Archemix Corp.
|Factor IXa
|Percutaneous coronary intervention
|Phase II
|NOXXON Pharma
|Lymphoma patients (undergoing autologous stem cell transplantation)
|Phase I
|NOXXON Pharma
|Type 2 diabetes and diabetic Nephropathy
|Phase I
|Antisoma/Archemix Corp.
|Phase II
Aptamers as delivery tools.
|RNA, 2′-F-Py
|siRNA, Toxin, QDs, nanoparticles and chemiotherapeutics
|Prostate cancer therapy
|RNA, 2′-F-Py
|HIV infection
|RNA, 2′-F-Py
|HIV infection
|Au NPs
|Doxorubicin, Au-Ag NPs
|Mucin 1
|QDs, photodynamic therapy agents
This work was supported by funds from CNR, from AICR No 11-0075 (L.C.), MIUR grant, MERIT RBNE08YFN3_001 (VdF), AIRC No 4971 (L.C.) and from the Italian Ministry of Economy and Finance to the CNR for the Project FaReBio di Qualità.


text:
Marched to west side of the river to Pineville while the dam was being built to enable the gunboats to pass down the river.
He met me at Pineville, and we took the trolley car to his home.
The railroad from Pineville will be completed in less than a month, which will give connection by rail with Louisville.
There's a good train for Pineville, not too many stops, at twelve-three.
Whether he would have accepted battle after Fremont had reached him at Pineville, is a matter of conjecture.
It is a long journey, and you know school will soon begin at Pineville.
Old Milt Yungthank at Pineville has looked ater their bissiniss fer nigh twenty year.
Suddenly the delivery of coal in cars to Pineville was stopped.
The letter had arrived a week ago; perhaps he was in Pineville at that very moment!
There were not many policemen in Pineville, and most of them knew Mr. Bunker.


text:
Amidst news of volatile stock markets, and job and real estate reports arose positive statistics for U.S. retailers in 2011. U.S. retail and food services sales were up 8% July 2011 through September 2011, as compared with the same period the prior year, according to the U.S. Census Bureau. Health and personal-care store sales in particular rose 4.5% in the same time range.
While retailers—and the rest of the country—hope the worst is behind us, a new economic landscape with new rules of engagement is emerging. Specifically in the beauty industry, retailers must navigate a world with increased competition, more discriminatory customers and thinner wallets. It is a challenge, but successful beauty retailers say it is not an impossible mission.
"The beauty retail game has changed greatly," comments Michael Batt, president of Beans Beauty, a retailer with four brick-and-mortar locations in Pennsylvania as well as a strong Internet presence. "The smaller beauty retailer is working much harder to vie for business." He says business traditionally clinched by small beauty supplies has been lost to drugstores and supermarkets carrying diverted brands, as well as to bargain hunters on the Internet.
"Everyone has gotten into beauty," agrees Dominick Costello, president of Ricky's NYC, a regional beauty-store chain with locations primarily in New York City. Costello has seen increased competition from online sources, as well as the eagerness of largely apparel retailers, such as JCPenney, to jump into the beauty arena. "There's a lot of fanfare about the beauty industry and how it's growing. It will grow, but it is highly saturated," adds Costello.
Despite increased competition, savvy beauty retailers still have a chance to survive—and even thrive—in today's environment. San Francisco Bay Area beauty-retail chain Peninsula Beauty, for example, has remained profitable throughout the challenging economic environment, and has even seen sales grow 6% in 2011 as compared to the prior year, says Jerret Schaar, chief operating officer.
Peninsula Beauty's growth hasn't happened by chance, but is the result of a multifaceted strategy well executed by its leadership. "Beauty consumers have more choices than ever. We have to deliver more value in our offers, more smiles from our sales staff and more solutions to our customers' beauty problems. Even though we sell tangible products on the retail floor, we have to think about selling our service and product knowledge just as much as the physical products," Schaar says.
Successful beauty entrepreneurs offer proof that the future can still look bright for today's small beauty retailers. We've asked several experts to provide advice on how to effectively manage a beauty store in a difficult economic marketplace. Here is what they have to say.
[Image: thinkstock.com/Hemera Collection]
News of a big-box store opening in a small store's sales territory can make even the most courageous small retailer cringe. Yet there are specific advantages a small beauty retailer provides that will never be duplicated by a retail giant.
"The biggest advantage is that we can navigate quickly on things. If there is a new product, idea or initiative, we can make it happen quickly. We don't have a political chain of commands to go through," says Costello.
Ricky's NYC has a reputation for providing hip, sometimes hard-to-find items, says Costello. When a hot new product becomes available, "We can bring it in [within] a matter of weeks or even days. If there is suddenly a big demand for a product, it doesn't have to go through eight levels of management before it gets into the stores."
Schaar calls this phenomena "retail rhythms," and his chain of stores has mastered the art of reacting quickly and implementing a strategy to sell to the latest fads. Retail rhythms can be something as simple as strategically placing designer umbrellas on a rainy day, and as sophisticated as bringing in products based on new celebrity trends or providing do-it-yourself kits in response to the rough economy. "We can launch online keyword ads or in-store merchandising end caps to harness sales trends faster than the big-box stores. Less meetings and approval requirements equal faster retail responses," comments Schaar.
Another important advantage of smaller retailers, say experts, is its staff. A good sales staff provides an invaluable resource to consumers that will drive traffic to your door—and away from the big boxes.
"Box stores lack soul. They are cookie-cutter operations planned like a science. The staff often reflects the same lack of depth and caring," says Batt. "We stock our stores to reflect what we believe our audience wants to see. Our staff is devoted to our culture—a culture that is passed down from the owners and that is obtainable and on the job on a daily basis. There is a genuine sense of pride and community in a smaller operation, and the customer feels that."
Staff is an integral part of a well-working store, and "extremely important during economic downturn," adds Costello.
"Our employees are our No. 1 asset," agrees Batt. "We've come to realize that no matter how well we set the table our employees are responsible for bringing the customers back."
The importance of a good team, especially in difficult economic times, makes the hiring function extra important for retailers. Peninsula Beauty follows a tried-and-true hiring philosophy, says Schaar. "Hire the smile, train the skill." The company focuses its resources on teaching product knowledge to naturally service-oriented employees and "quickly removes" those who are not service oriented, says Schaar. It has also invested in hiring a part-time sales and service coach for its staff of more than 50 people.
Training and enthusiasm are the keys to a successful employee, says Costello. The company looks for employees with great morale and willingness to work. Skills are honed with a variety of training opportunities, which include ongoing product training, and sales and management seminars for staff members who show growth potential. "We try to nurture people and give them opportunity to learn, grow and be confident on the sales floor. Good employees are such an important thing," says Costello.
In addition to offering training, it is also important to recognize employees for a job well done. Schaar, for example, has employed a variety of staff bonuses and incentive programs to energize employees.
[Photo caption: Peninsula Beauty uses a part-time sales and service coach to keep its employees primed for great customer service and sales.]
[Image: Courtesy of Peninsula Beauty]
Dig into the history of Ricky's NYC and you'll find a chapter in its 20-plus-years history that includes kids beauty supplies. While dedicated children's sections were in its stores at one point, they are no longer there today.
"We tried to do a kids thing, and it was a drain on us. It was a great idea. The store did pretty well with it, but because it was so specialized it needed special attention. It was distracting us from our bread and butter," explains Costello. "We've made mistakes, and we've tried different variations of our business; but we've found that when you aren't focused, it takes away from what you're doing every day."
Costello's takeaway advice for other beauty retailers? "Stick to what you do and do it well." Ricky's NYC has found an identity in its urban vibe and is known for supplying the best brands and always being in stock, says Costello. "At Ricky's, we worry about us much more than anyone else. We forge forward with our philosophy. We have become a New York institution."
Finding a niche is also an opportunity to grow business because you are offering your customer something special that can't be found anywhere else. "Find your niche and what makes your store unique—capitalize on that. Be different. Be special. Be a destination," says Batt. When competing against big-box stores, "We can purely capitalize on not being the same and offering a better shopping experience."
Equally important in a rough economic environment is that retailers should also be savvy cost cutters.
Batt advises being a student of sales reports. Know what is moving and let go of slow inventory through markdowns. Quickly letting go of slow inventory is one effective way of staying profitable.
A critical analysis of retail space can lead to tremendous cost advantages. If you can execute your business model using less floor space, work with your landlord to concentrate square footage, recommends Batt.
Schaar reminds retailers to remember "ROI over ego." He suggests that all marketing and advertising efforts remain measurable so that advertising dollars are used as efficiently as possible. In an effort to keep costs low, he also advises retailers to re-shop vendors for the most competitive offers as well as identify opportunities to increase energy efficiency, thereby lowering bills.
"Ask your local utility [agency] to perform energy audits on your business to identify opportunities for more efficient lighting and HVAC usage," says Schaar. "Rebates are frequently available for work and equipment. We changed our MR16 light bulbs from 50W to 35W and saved big last year."
Finally, retailers also urge that businesses examine their number of employees and whether every position is necessary. "Everyone in the company needs to be busy. If you have people who aren't busy, then you have too much staff. No one likes to be overworked. But stimulation is good, and people like to be engaged so that their days go by quickly," says Costello. He also advises that managers stick to their best sellers. "You have to work with what you can control. You can control your payroll and what you're buying week to week."
Rather than sitting on your loins and reminiscing about the good old days, focus on the "positive side of these tough times," says Batt. "This difficult economy promotes a spirit [of trying] harder. It's like any team sport: Don't lose sight of the goal. And the fight to get there is so gratifying when you realize that the struggle makes the team a unified force. I can't express how much I count on our people. Customers are gained one at a time. Dazzle them with service. Let them tell someone else how special their experience was at your store."
Leah Genuario is a Hawthorne, NJ-based freelance writer. She is the former editor of Beauty Packaging.
[Photo caption: Ricky's NYC has a reputation for providing hip, sometimes hard-to-find items.]
[Image: Courtesy of Ricky's NYC]


text: On 06/11/2010 12:19 PM, "Mgr. Šimon Tóth" wrote: > On 11.6.2010 18:41, Martin Siegert wrote: > >> >> It all depends on whether we want to break the meaning of nodes=N being >> totally equivalent to nodes=N:ppn=1. >> 1) if we stick to the meaning of nodes=N just being a shorthand for >> nodes=N:ppn=1 then -l nodes=4+procs=4 makes just as much sense as >> nodes=4:ppn=2+procs=6, i.e., there is no problem. >> 2) if we change the meaning of nodes=N to become "give me exclusive >> access to N nodes" then we need to define what -l nodes=N+procs=M >> means. >> >> I actually vote for (1). E.g., what is the default if neither nodes nor >> procs is specified? Currently that is nodes=1:ppn=1, i.e., the default >> for nodes is 1 and the default for ppn is one. That logical extension is >> that if only nodes is specified then the default value for ppn should be >> used. I.e., nodes=N means nodes=N:ppn=1. >> But that leaves us with the problem of how to specify exclusive access >> to a node. What about a keyword ALL as in nodes=4:ppn=ALL ? It is a >> logical extension of the current syntax and is easy to understand. >> And then things like -l nodes=1:ppn=ALL+procs=42 make total sense >> (at least to me). >> > That's not good enough. How do you tell Torque that you want at least a > 4 CPU node, but when you get it, then you want all the CPUs? > > > How about just add #exclusive or other appropriate keyword. Ken


text:
Power Tech Industries provide a complete range of electrical construction and services.
We offer 24 hour service to fit the needs of the Oilfield Industry.
Our employees are experienced, skilled, and professional so we can provide our Oilfield Industry Customers with superior service to fill all their electrical needs.
Power Tech Industries services South East Saskatchewan and Western Manitoba, with 2 branches located in Estevan, Saskatchewan, and Carnduff, Saskatchewan.
Power Tech Industries offers a full range of electrical services and can manage all elecrical needs ranging from simple electrical repair calls to plant construction from design stages to start up and commissioning.
Power Tech Industries is always on the lookout for skilled, experienced, and professional Journeymen Electricians, Apprentice Electricians, and Helpers who are interested in learning the Electrical Trade.


text:
- Last login Nov 12, 14 @ 6:25 am
Online Purchase of Supplements
Most of the people in today's time and age live a pressurized lifestyle and they donot pay heed to the kind of nutrition they are getting. People often eat junk food which is low in nutrition and doesnot provide the body with essential vitamins. The constant intake of low calorie food would lead to serious malnutrition and health issues following the same busy way of living. Vitamins supplementation ensures you a good intake of vitamins even if your daily diet is not healthy as per your body's requirements. Buying [URL] is an easy way to get your daily supplements at an affordable price. Understanding what supplementis essential and how they benefit is only half the battle you are trying to fight for being healthy. It is much better to buy supplements online rather looking for them in physical stores. Many of these supplements are not conveniently available and besides it will not give you the ease of saving time and money from shopping online. When you choose to buy supplements online, you will get the best quality on discount prices suiting both your health and budget. You can also choose to buy these in bulk which can get you better savings on your orders. The supplements are shipped promptly in secure packaging so that you receive your order in perfect condition. The best thing about buying supplementsonline is that you can order it in a few clicks. Browse over internet to get better search results.2 Weeks ago in Sports


text:
2B Bedford Road
St Ives, United Kingdom
The Book Gallery now deals exclusively with material relating to the creative aspects of West Cornwall. This includes: Books, Manuscripts, Prints, Posters, Ephemera, Photographs, Exhibition Catalogues, Original Works of Art and Items of Archival Interest.
This seller's inventory is temporarily unavailable. Please try your search with another AbeBooks Bookseller.
Payment via secure abe.com link is recommended. Otherwise, prices are net, plus shipping costs. Books are sent, with invoice payable on receipt, to known UK customers only. Payment with order is required from overseas customers. Cheques on UK Banks or International Money Orders in UK pounds Sterling. No US Dollar cheques. Books will be sent overseas by airmail unless otherwise requested [Guide price for airmail plus insurance = £6.50].
Orders usually ship within 2 business days. Shipping costs are based on books weighing 2.2 pounds, or 1 KG. If your book order is heavy or oversized, we may contact you to let you know extra shipping is required.


text:
It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is elective but will dramatically raise your chances of your profile being viewed by interested members. Write a few sentences about yourself, your pasttimes and upload your nicest photo of yourself.
Use our website's advanced search to discover over 60s members who match your desired requirements. Or just scan through listings and discover daters that you find attractive.
Identified someone who looks right? Send a note to them or just a wink and find out if they're interested in you. With a little luck you'll be on your way to discovering your ideal date.
And start dating


text:
By Laura Petrecca, USA TODAY
First the good news: Nine in 10 people said they were satisfied with their jobs or the work that they do — and that remained steady throughout 2008, despite the economy.
And now the bad, even if it's not so surprising: The number of people who said their employer reduced the size of the workforce rose dramatically during the year, from 15% in the first quarter to 23% in the fourth quarter.
That's according to a survey from Gallup and health management company Healthways. Nearly each day in 2008, about 1,000 adults were asked about their physical, emotional and economic and workplace well-being.
When it came to their work environment, many of the 355,334 people surveyed by phone were positive. But there were some labor pains.
Just 47% of respondents from Hawaii said they were satisfied with their jobs, used their strengths at work, were treated by a supervisor as a partner and worked in an "open, trusting environment." That was the lowest score of any state on a work environment index that was compiled by calculating positive responses in those four areas.
Utah nabbed top honors, with 59% of its respondents saying those four elements were prevalent in work lives.
Among the biggest differences between Utah and Hawaii: 73% of Utah respondents said their supervisor created a trusting environment, while only 58% of folks in Hawaii felt that way. The national average was 65%.
The Gallup-Healthways AHIP Congressional Report didn't offer any insights into why Utah ruled and Hawaii ranked so poorly on the workplace front.
Hawaii's residents took the No. 1 slot in another survey area, emotional health.
"Maybe having a job while you're in paradise may not be all that great," says Jim Harter, a chief scientist of workplace and well-being at Gallup.
Utah has done well in separate workplace studies, as well. After considering factors such as unemployment rate, job growth, income growth, median household income and the cost of living, Moody's Economy.com named its capital, Salt Lake City, the best U.S. city to work in for 2007 and 2008.
But those glory days have faded, says Gus Faucher, Moody's Economy.com director of macroeconomics. Utah's housing boom turned into a bust later than most states.
The national recession began in December 2007, according to the National Bureau of Economic Research. Salt Lake City's recession began in November 2008, according to Moody's Economy.com.
From a non-economic angle, Faucher says he can see why Utah would earn strong marks on the work front. "The state is really Mormon, so there is a sense of solidarity" among many employees, he says. "People feel very connected to each other."
Also, with its high birth rate, Utah has a robust population of younger employees who often add enthusiasm to the workplace, Faucher says.
That's the case at the Wasatch Music Coaching Academy in Salt Lake City, school owner David Murphy says. Most instructors are between 22 and 35 years old and are extremely passionate and excited about teaching students, he says. Murphy, 52, who says he has a "dream" job, takes a collaborative approach in managing all staffers: "I see myself working side by side with my staff, not over my staff."
Other job-related survey findings:
•More money, more travel. The higher the salary, the longer the commute to work, with those making $7,500 or more a month traveling for about 24.4 minutes on his or her way into work. The trip time for folks earning less than $2,000 was about 21.6 minutes.
•Big salaries don't buy workplace joy. "Looking across the states, work environment satisfaction is independent of income," Harter says. People at the same wage level had varying feelings about their workplaces.
•Pink slips make a livelihood look rosier. Those employed at companies having layoffs reported greater job contentment as the year progressed. When faced with pink slips, people "appreciate their jobs more," Harter says.
TELL US: Are you satisfied with your job and the work you do?
Guidelines: You share in the USA TODAY community, so please keep your comments smart and civil. Don't attack other readers personally, and keep your language decent. Use the "Report Abuse" button to make a difference. Read more.


text:
It has been about a year since the U.S. Supreme Court overturned the Defense of Marriage Act, or DOMA, voiding the federal definition of marriage as an institution pertaining exclusively to a man and a woman.
During the last 12 months, the legal status of people in same-sex marriage has continued to evolve, particularly with regard to the most important social insurance retirement programs -- Social Security, Medicare and the Veteran's Administration.
The ruling quickly cleared the way for same-sex couples to receive these federal benefits when they were married in or living in a state that recognizes same-sex marriage, but the situation remains more restrictive when a couple lives in a state that doesn't recognize same-sex marriage. It means same-sex married couples are still unable to receive Social Security spousal benefits if they were married in one of the states that allows same-sex marriage, but live in a restrictive state.
Last week, Social Security also began processing claims in states that do not recognize same-sex marriages but do recognize other sorts of non-marital legal relationships like civil unions or domestic partnerships.
Attorney Janis Cowhey, tax partner and co-leader of accountancy Marcum's LGBT and non-traditional family practice group, says that committed gay couples living in states where they can't legally be married should promptly tie the knot in a state or the District of Columbia where they can marry. "Go elsewhere, get married and, hopefully, your state will change, but get the clock started."
The reason for speed is that varying wait times are imposed before someone can be eligible for benefits. For example, a couple must be married a year before filing for spousal retirement benefits. To claim survivor benefits, a widow or widower must have been married nine months. For a divorced couple to claim spousal benefits, they must have been married 10 years.
Veteran's benefits are also restricted
Couples that live in states that don't allow gay marriage are currently unable to apply for dependent benefits or survivor pensions from the Department of Veterans Affairs. The National Cemetery Administration is allowing same-sex couples to be buried next to each other in veteran's cemeteries, however.
Most Medicare benefits have become available to same-sex married couples no matter where they live. But if you are one of the relatively few people who don't qualify for Part A hospitalization at no cost because you haven't worked enough quarters under Social Security, you may not qualify based on your spouse's record either because Social Security's rules apply.
If you are facing these and other restrictions, don't be too discouraged, Cowhey advises. She believes these retirement planning problems will eventually be resolved. "The situation just keeps changing, and all these cases keep coming down the legal pipeline, although I don't think a definitive resolution will come in fewer than two years," Cowhey says. "It is going to take a Supreme Court decision or Congress will have to pass a law that says a state has to accept other states' marriages, and things like that take time."


text:
|ROTWAND at ART BRUSSELS 2010
|We are very pleased to announce our participation at ART BRUSSELS 2010
April 23rd - 26th 2010
The focus of our booth 3A-06 in Hall 3 will be on British artist Clare Goodwin (*1973 Birmingham). Taking her source material from discarded garments and retro manuals, found whilst roaming the 'museums of the unwanted', Goodwin presents a number of abstract and geometrical compositions. Beyond these material references, they evoke (not merely retro) images but also engage one with specific social groups and personality types associated with the 1970s/80s. Goodwin calls her paintings "portraits", giving them names such as "Linda", "Pearl", "Dick", "Peter and Jill". She favours the "married couple" or the "divorced couple" as typical life forms, because to her they best represent, and easily fit into the world she grew up in. The alleged coldness of the geometric abstraction is emotionally charged with the precise colour harmonies, dissonances and consciously replicated stereotypical ornamental details, such as the ubiquitous grey-blue diagonal stripes in men's ties-, i.e., elements associated with the aesthetic sensibilities of an era. Colour fields of orange, violet and brown often dominate the canvas, rhythmized by black, grey and white rectangular motifs and lines.
Furthermore we have works by: Klodin Erb, Tatjana Gerhard, Chloe Piene and Chiharu Shiota.
For any further information please do not hesitate to contact us.
We are looking forward to seeing you in Brussels!
Sabina Kohler and Bettina Meier-Bickel


text:
Georg Christian Unger
Georg Christian Unger (25 May 1743 – 20 February 1799) was a German architect. He was a pupil of the architect Carl von Gontard and served for Frederick II of Prussia. He created a lot of buildings in Potsdam, e.g. Brandenburg Gate, and Berlin, e.g. at the Gendarmenmarkt.[1]
References[change | change source]
|Wikimedia Commons has media related to: Georg Christian Unger


text:
He dodged the first bullet when he was accused of a sexual relationship with an underage boy earlier this month but now Kevin Clash is facing an additional accuser.
According to a report, a 30-something gay male has come forward and claimed that Clash, who serves as the voice of Elmo, had a sexual relationship with him when he was just 15 years old in 1993.
The new lawsuit claims, "[Kevin] groomed [the accuser] to gain his trust by, among other things, taking him to nice dinners and giving him money."
Furthermore, "[Clash] trolled gay telephone chat line rooms to meet and have sex with underage boys."
As for why he waited until now to bring it up, the accuser says he "did not become aware that he had suffered adverse psychological and emotional effects from Kevin Clash's sexual acts and conduct until 2012."
He wants $5 million for his trouble.


text:
Rhydian will be making an appearance at the Millennium Stadium, Cardiff during the Judgement Day rugby matches.
In another double-derby-day extravaganza on Easter Sunday, 20 April 2014, Cardiff Blues take on Scarlets at 2pm and Newport Gwent Dragons will face the Ospreys at 4.45pm as Judgement Day returns to the Millennium Stadium. The unique event, in conjunction with RaboDirect PRO12, S4C and BBC Wales, is the second of a four year deal which sees the Blues and the Dragons play their 'home' fixtures against alternating regional rivals on the same day at the iconic stadium.


text:
Collectible Football Helmets
Leather football helmets were introduced in 1893, after doctors warned that a blow to the head could be fatal or cause 'instant insanity.' Football helmets didn't really catch on until the 1920s, however, and weren't mandatory until the 1930s.
When most people think of classic vintage football helmets, they think of the leather padded style popular in the 1940s. The first logos were put on helmets in 1948, and leather was soon phased out. The helmets most valued by collectors today are the older leather ones, with the exception of more modern helmets worn (and/or signed) by famous players, and those with logos which are no longer in use or from teams that no longer exist.
Best of the Web ("Hall of Fame")
Vintage Football Card Gallery
This great database of pro and collegiate football cards from the 1950s and 1960s offers scanned images of cards fo… [read review or visit site]


text:
On Wed, 14 Jun 2006 13:38:05 -0500
"Tarun Kundhi" <tkundhi at inebraska dot com> wrote:
> I'm still having interfaces issues with a new monowall configuration
>I'm trying to get setup. I've disabled everything I could in the BIOS
>and pulled my Quad Port Intel 1000 NIC card but I still can't
>recognize the onboard NICs properly. The onboard interfaces use with
>the Intel 82573V chipset. My research indictaes these interfaces
>should use the em4 driver but they appear as sis0 & sis1. They won't
>function under monowall but I do see lights on the cards so I'm not
>thinking it is a hardware issue. Is there a way to force a specific
>NIC driver at boot?
The sis0 and sis1 are the default config cards. You need to input
your NICs or autodetect them. You do this from the console on first


text:
By Alison Lapp, For The Associated Press
An ardor for arbors does not cool with the seasons, but the cold months hold special dangers for trees: windstorms, heavy snowfall and dry air that can turn branches brittle.
If a storm has come and gone, a little know-how — and the willingness to call a professional — can guide any gardener.
Often, elements that are harsh on humans barely harm sturdy trees. After a storm, grab a broom and tour your lot. Only trees with trunks bowed by snow need be touched.
Gently shake the trunk and bounce branches from underneath, using the bristle end of the broom to dislodge snow. After an ice storm, do nothing at all, said Patrick Parker, a plant health care specialist at the SavATree lawn service. The icy coat acts as both a load and support.
If more severe damage has occurred, including large broken branches or a split trunk, a decision must be made whether it's worthwhile to save the tree, depending on its condition and value. Uncertain owners should call an arborist to make the determination, Parker said, because "small rips and cracks over time can impact the structural integrity of the tree" and cause it to tumble unexpectedly.
For salvageable trees, the next question Parker advised asking is: "Can I repair the tree myself or should I call a professional?"
Major repair often requires chainsaws and climbing equipment, which can be dangerous for those unused to Tarzan-style yard work. When removing broken branches yourself, Michigan State University's Extension Service recommended making the cut at the nearest lateral branch, bud or main stem, not in the middle of a branch.
"Such careless pruning may result in death of the entire branch or in excessive sprouting and the eventual development of more problems later on," according to information from the university.
It further suggested using shears or a pole-pruner for branches with a 3-inch diameter or smaller, and a sharp saw for larger branches.
The most common way for bark on the trunk or branches to rip is when trees are struck by lightning, and tears can lead to wood decay. Michigan State counsels owners to trim loose bark back to where it's solidly attached to speed healing.
Hope remains even after tree roots have been pulled above ground, as long as they are shorter than 25 feet and half the roots are still in the soil.
A power lift is usually needed to pull the tree upright, according to Michigan State's extension service, and soil should be filled in around the roots and watered once the tree is back standing. Several guy lines tied to anchors 12 to 15 feet from the base will hold the tree in place until the roots regain a firm hold.
Tree owners often must wait until the spring thaw to fully nurse their arbors through the recovery process.
At that time, Parker recommended regularly fertilizing the soil to increase root health and checking for bugs or illness. "Insect and disease issues become more damaging after a tree has been through the stress of a storm," he said.
Like their two-legged caretakers, trees that are kept in good shape throughout the year are less likely to be harmed when the going gets rough. Parker suggested "developmental pruning" — forming the tree's structure early in its life by trimming to create evenly spaced branches that don't compete with one another for sunlight.
"When a tree is young, you can influence its future architecture a lot," he said, noting that cables and supports can be added to keep older, untrimmed trees stable.
Selecting climate-appropriate species also increases their chances of surviving the stormy season. Rapid-growing varieties like Chinese Elm, Silver Maple, Box Elder and various poplars have brittle, easily broken wood, according to the extension service, which notes that homeowners should avoid planting such species near buildings and utility poles.
Hardier oaks and other maples fare better in winter weather, Parker said, and small ornamental varieties typically suffer less damage than large shade trees.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Conversation guidelines: USA TODAY welcomes your thoughts, stories and information related to this article. Please stay on topic and be respectful of others. Keep the conversation appropriate for interested readers across the map.