text:
The New York Times
Third Angelby Alice Hoffman
"Alice Hoffman is my favorite writer." –Jodi Picoult
Alice Hoffman is one of our most beloved writers. Here on Earth was an Oprah Book Club selection. Practical Magic and Aquamarine were both bestselling books and Hollywood movies. Her novels have received mention as notable books of the year by the New York Times, Entertainment/b>
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"Alice Hoffman is my favorite writer." –Jodi Picoult
Alice Hoffman is one of our most beloved writers. Here on Earth was an Oprah Book Club selection. Practical Magic and Aquamarine were both bestselling books and Hollywood movies. Her novels have received mention as notable books of the year by the New York Times, Entertainment Weekly, the Los Angeles Times, and People magazine, and her short fiction and nonfiction have appeared in the New York Times, The Boston Globe Magazine, Kenyon Review, Redbook, Architectural Digest, Gourmet, and Self.
Now, in The Third Angel, Hoffman weaves a magical and stunningly original story that charts the lives of three women in love with the wrong men: Headstrong Madeleine Heller finds herself hopelessly attracted to her sister's fiancé. Frieda Lewis, a doctor's daughter and a runaway, becomes the muse of an ill-fated rock star. And beautiful Bryn Evans is set to marry an Englishman while secretly obsessed with her ex-husband. At the heart of the novel is Lucy Green, who blames herself for a tragic accident she witnessed at the age of twelve, and who spends four decades searching for the Third Angel–the angel on earth who will renew her faith.
Brilliantly evoking London's King's Road, Knightsbridge, and Kensington while moving effortlessly back in time, The Third Angel is a work of startling beauty about the unique, alchemical nature of love.
Editorial Reviews
The New York Times
In this elegant and stunning novel, veteran heartstring-puller Hoffman (Here on Earth; Seventh Heaven) examines the lives of three women at different crossroads in their lives, tying their London-centered stories together in devastating retrospect. High powered New York attorney Maddy Heller arrives in 1999 London having had an affair with Paul, her sister Allie's fiancé,; she must now cope with the impending marriage, and with Paul's terminal illness-which echoes the girls' mother's cancer during their childhood. Hoffman then shifts to heady 1966 London and to Frieda Lewis, Paul's future mother, who falls for a doomed up-and-coming songwriter knowing he will break her heart. The narrative then shifts further back, to 1952 and to Maddy and Allie's future mother, Lucy Green. A bookish 12-year-old wise beyond her years, Lucy sails with her father and stepmother from New York to London for a wedding. There, she becomes an innocent catalyst to a devastating event involving a love triangle. Hoffman interweaves the three stories, gazing unerringly into forces that cause some people to self-destruct ("There was no such thing as too much for a girl who thought she was second best") and others to find inner strength to last a lifetime. (Apr.)Copyright 2007 Reed Business Information
In a haunted London hotel, the lives of three women intersect across time. A jealous sister cheats with her brother-in-law to-be, a chambermaid beguiles a rock star by composing an original lyric, and a 12-year-old girl is enlisted as go-between for doomed lovers. In each vignette's time warp, the hotel ghost conducts his nightly seventh floor rampage. Hoffman's unsettling and compelling 20th novel weaves the sadness and loss of ordinary people coping in extraordinary ways into tensile strength. The book and audio share the same haunting cover art depicting the fragile third angel who anonymously walks among us to give us aid. Reader Nancy Travis is able to unravel the threads of interlocking plot pieces without drawing the spotlight, allowing the story to outshine the voice reading it. Essential for fiction collections. [Hoffman's Here on Earth was an Oprah Book Club selection in 1998.-Ed.]
Judith Robinson
Once again, novelist Hoffman (Skylight Confessions) weaves a mesmerizing tale of the human condition, this time examining the nature of love. Set in London, her new novel tells the story of three different women, tangentially connected. The book's first part focuses on self-absorbed Maddy Heller, who has always coveted her sister Allie's life. That obsession continues when she has an affair with Allie's terminally ill fiancA©, Paul. The second part travels back in time to follow Paul's mother, Frieda, as she becomes involved with an engaged and tragic rock star. The final section concerns Maddy and Allie's mother, Lucy Green, who was in the middle of a fraught love triangle many years before having the girls. Each of these women has lost her faith and each searches for the one angel on earth who can renew it for her. A solid story with a haunting plot line and interesting characters, this latest novel is sure to please Hoffman's fans and win over new readers. Recommended for all public library fiction collections.
Nanci Milone Hill
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
— The Chicago Tribune
"Like Michael Cunningham's 'The Hours,' Hoffman' s tale weaves the stories of women at key moments in their lives with revelations both stunning and inevitable."
— The Pittsburgh Post Gazette
"Its realism, combined with a refreshing lightness and its success in portraying emotion with empathy, draws the reader into a deep involvement with the books' appealing yet flawed characters. Each woman faces up to her challengers in her own way, proving that everyone in the end is responsible for his or her own destiny."
— The Economist
"Hoffman's luminous language bounces us into accepting not only coincident but also its consequences."
— The Boston Globe
"Alice Hoffman paints her books in big strokes and bright colors, with slashes of romantic reds and blacks. She's a teller of fairy tells, well-worn or new."
— The Columbus Dispatch
"With a graceful nod to the power of redemption, Alice Hoffman reminds readers we are all hurt and broken, stumbling through life and fumbling for love, but sometimes we can still find out way to where we want to go."
— Charlotte Observer
"Headstrong women, reckless love affairs and a liberal dusting of the supernatural are the pleasurable trademarks of an Alice Hoffman novel….Her passionate storytelling and intense characters make a deeply personal connetion that should bewitch old fans and new readers alike."
— People Magazine (A "People Pick," 4-stars)
"Un-put-downable….The Third Angel soars….an unforgettable portrait of the depth of true love."
—USA Today
"Hoffman makes vivid and new the realization that grace, beauty, and forgiveness can arise out of the most devastating situations."
— Elle
"Alice Hoffman's richly layered novel, The Third Angel, is one of her best."
"Hands down, this captivating book is one of Hoffman's best. It follows three women's lives as they flow together and apart, tributaries linked by the same tragic love story and mysterious ghost. You'll want to start it again as soon as you're done."
— Redbook
"A book that's hard to put away completely. Even long after it' s finished, you may find its characters sneaking, like ghosts, back into your head."
— St. Louis Post Dispatch
"These stories capture the fleeting happiness of doomed, misguided love."
— Minneapolis Star Tribune
"Elegant and stunning….Hoffman interweaves the three storioes, gazing unerringly into forces that cause some people to self-destrut and others to find inner strength to last a lifetime."
— Publishers Weekly (starred review)
"One of her best…an exceptionally well-structured, beguiling, and affecting triptych of catastrophic love stories….Not only is Hoffman spellbinding in this incandescent fusion of dark romance and penetrating psychic insight, she also opens diverse and compelling worlds, dramatizes the shocks and revelations that forge the self, and reveals the necessity and toll of empathy and kindness. Hoffman has transcended her own genre."
— Booklist (starred review)
"The Third Angel places Hoffman at perhaps the pinnacle of her bountiful literary talents."
"A mesmerizing tale of the human condition….sure to please Hoffman's fans and win over new readers."
—Library Journal
"The Third Angel is brilliantly crafted, deeply moving, and utterly enchanting. I loved these characters for their complexity, their unpredictability and for the way they showed subtle and shifting nuance in human nature. One of the best things about Alice Hoffman's writing is that she grounds you in detail and also frees your imagination to soar to places it has never beenoften simultaneously. Reading her is immensely satisfyingand addictive!"
— Elizabeth Berg, author of The Day I Ate Whatever I Wanted
More Praise for Alice Hoffman:
"Alice Hoffman is my favorite writer." —Jodi Picoult
"With her glorious prose and extraordinary eyes . . . Alice Hoffman seems to know what it means to be a human being."
—Susan Isaacs, Newsday
"Alice Hoffman takes seemingly ordinary lives and lets us see and feel extraordinary things."
—Amy Tan
"Hoffman's characters, male and female, tend to be defined by the restless, lonely ache of what's missing in their lives, which becomes clear only when they fill the void with something either unexpectedly right or horribly wrong. Along the way, Hoffman seems to wriggle into their skin, breathe their air, and think their thoughts."
—Entertainment Weekly
Product Details
- 9780307409331
- Publisher:
- Crown/Archetype
- Publication date:
- 04/08/2008
- Sold by:
- Random House
- Format:
- NOOK Book
- Pages:
- 288
- Sales rank:
- 115,056
- File size:
Read an Excerpt
The Heron's Wife
Madeline Heller knew she was reckless. She had flown to London from New York two days ahead of schedule and was now checked into her room at the Lion Park Hotel in Knightsbridge. The air was still and filled with dust motes; the windows hadn't been opened in months. Everything smelled like cedar and lavender. Maddy felt hot and exhausted from her travels but she didn't bother to turn on the air conditioner. She was madly, horribly, ridiculously in love with the wrong man and it made her want to lie there on the bed, immobilized.
Madeline wasn't stupid; she was an attorney in New York. She was thirty-four years old and had graduated from Oberlin and NYU Law School, a tall woman with long black hair. Many people thought she was beautiful and smart, but none of those people mattered. They didn't know her. They had no idea she was a traitor to her own flesh and blood. They would never have guessed she would throw her life away so easily, without thinking twice.
There was good love and there was bad love. There was the kind that helped raise a person above her failings and there was the desperate sort that struck when someone least wanted or expected it. That was what had happened to Maddy this past spring when she'd come to London to help plan her sister's wedding. Allie hadn't even asked for her help; it was their mother, Lucy, who'd told Maddy she should go to London and assist with the preparations; she was the maid of honor after all. And then when she got there, Allie had already taken care of everything, just as she always did.
Allie was older by thirteen months. She was the good sister, the perfect sister, the one who had everything. She was a writer who had published an extremely popular children's book. When she walked down the street people often recognized her, and she was always willing to sign scraps of paper for someone's child or present a fan with one of the bookplates she carried in her purse. Once a year she came back to the States to give readings for what had become a perennially popular event where children dressed up in bird costumes. There were nine- and ten-year-old cardinals and ducks and crows all waiting on line to have their copy of The Heron's Wife signed. Maddy sometimes accompanied her sister on tour. She couldn't believe all the fuss over a silly children's story, one Allie had pinched from a tale their mother used to tell. Technically, the story belonged to Maddy as much as it did to her sister, not that she'd felt the need to write a book or change it inside out to suit herself.
The story was one Lucy Heller would tell down by the marsh where the girls had grown up. Lucy's own mother, the girls' grandmother, had waded barefoot into a pond in Central Park to talk to a huge blue heron. She didn't care what people thought; she just went right in. She'd asked the heron to watch over Lucy and he always had. Now Lucy had asked him to protect her own girls and he had come to live in their marsh in Connecticut.
"How can a heron watch over a person?" Maddy had whispered to her sister. She didn't have much faith in stories, even though she was only eight years old. In that way, she was very much the skeptic her mother had been.
"He can have two separate lives," Allie was quick to say, as though the answer was simple, if only Maddy could unwind the mysteries of the universe. "He has his heron life up in the sky and his life down here."
"I'm glad he can help us both," Maddy said.
"Don't be ridiculous." Allie was always so definite and sure of herself. "The blue heron only has one true love."
And so it came to be in Allie's book. There was a woman who married a man she loved. The couple lived in a house that resembled the one on the marsh where the sisters had grown up. There were the same tall silver reeds. The same inky black sky. The bride and groom resided in their house made of sticks and stones for nearly a year, in happiness and peace. And then one day, when the man was out fishing for their supper, there was a knock on the door. The woman answered and there was the groom's other wife, a blue heron come to look for her missing husband.
"How can you stand all these children around?" Maddy had asked at an especially crowded reading. They had runny noses. They were germ filled, noisy, and rude. And did they have to laugh so loudly? It was earsplitting.
In Allie's book, the heron wife was wasting away. Her feathers were falling out. She hadn't eaten a mouthful since her husband had left.
One of us wins and one of us loses, but which will it be? she asked the bride at the door.
"They're my readers. I want them to laugh."
Allie was the one who always came home for visits, but at long last Maddy was to be her sister's guest. Frankly, she'd avoided coming to London; she said she was too busy, but it was more than that. She didn't need to see how perfect Allie's world was. Finally, there was no getting around it; there was a wedding to attend to, after all. A wedding where Maddy would once again be the sidekick, the bad little sister who couldn't follow rules, who even as a grown woman was still afraid of ridiculous things, thunderstorms and mice, traffic jams and airplanes. She would most likely be made to wear a horrible dress of some dreadful synthetic fabric while her sister glowed in white silk or satin. Second-rate, second-best, the dark side of everything. She never believed men who told her she was beautiful and she shied away from friendships. She did her work and kept to herself, the sort of woman who could stand idly by while children removed a butterfly's wings or buried a toad in the mud. What people did on their own time was none of her business. Cruelty, after all, was a fact of life. It wasn't up to her to set the world right. That sort of thing was her sister's concern.
Because Maddy was only in London for a long weekend that April, arriving on a Thursday and departing late Monday, she and Allie had raced directly from the airport to the dressmaker's so that Maddy could have her fitting. They'd been close as children, but had grown apart, and were now as different as sisters could be. Allie, however, had done her best to try and choose a dress that would suit Maddy: blue silk, flattering, showing off Maddy's figure. As for Maddy, she hated the dress, but she kept her mouth shut. She had decided she would try to be the agreeable sister for once in her life. She even agreed to taste potential wedding cakes when they were done with the dresses. That was why she was here. To help her sister.
They went to the baker's and tasted half a dozen confections, but the buttercream frostings were too heavy and the chocolates were too rich. Allie hadn't seemed satisfied with anything. She said she thought wedding preparations were a waste of time. In the end, she chose a plain yellow cake that had been made from her own recipe. She hadn't really needed Maddy after all.
Maddy was still in her compliant mode. "Good decision," she said. "Plain is the way to go. Less chance for anything to go wrong."
Not that she believed in that particular philosophy when it came to herself. Plain was good for Allie, not Maddy. Maddy was greedy and she always had been. She used to steal from her sister, headbands, jewelry, T-shirts. If this had been her wedding cake, she would have wanted mousse and jam and chocolate and brandied apricots and spun sugar. There was no such thing as too much for a girl who always thought she was second-best.
The day after the cake-tasting adventure, both sisters were curled up in bed with stomachaches under a comforter. They wore pajamas and socks. When they were children, they hadn't needed anyone but each other; it felt that way again for an hour or two as they sipped cups of tea. But there was no way to regain what Allie had ruined when she'd left home. When it came down to it, they really had nothing in common anymore. It had been seventeen years since Allie had gone to college in Boston. She went off to London in her junior year, returning only for a week or so at a time. She'd deserted Madeline, left her alone in the big house in Connecticut with their parents, who had reunited after several years of leading separate lives. The Hellers had no close neighbors and Maddy had no friends. She was standoffish in the way that lonely people often are. After her sister left, Maddy grew more isolated. Even when she went off to Oberlin, she was the only one who came home for Winter Term or spring break. When Allie's letters arrived, Maddy refused to read them. Instead, she went out to sit in the reeds. On days when the sky was clear she would sometimes see the blue heron who lived there. She had read that most herons live in pairs, the larger male and the more delicate female, coupled for life, but this one was alone. He was far off, across the water. She often called to him, but he didn't seemed to hear her. He never once looked her way.
Allie's flat off of Bayswater was airy but nondescript, not at all Maddy's style. Nothing to envy. Simplicity once again. Allie's wardrobe was full of wool and cashmere in shades of gray and navy and black. Practical clothes that were well tailored. Maddy knew this because she'd sneaked a look in the closet while Allie was in the shower. She felt as though there was a mystery about her sister, some essential detail that would explain her superhuman abilities to do the right thing. She didn't find any clues in all her searching, although she did discover that the single splash of color in the closet was a sheer pink blouse, a birthday present sent by Maddy last fall from Barneys. She couldn't help but notice that the store's tag was still attached.
The day after the wedding cake fiasco, they went out to lunch with the bridesmaids, even though they still had stomachaches. There was Georgia, Allie's best friend, who was the art director of the publishing company that had published Allie's book. Suzy, a transplanted Texan who had been a student along with Allie during junior year and had married an Englishman. She was now the mother of nine-year-old twin girls, so ensconced in her adopted city that she had a lilting British accent. The third friend, Hannah, taught hatha yoga and lived in the same building as Allie. Allie had been one of her students, and still took a class once a week. Hannah was very tall, and she wore white for nearly every occasion. She looked like a cat, as if she could stretch out and bend in two.
"At last, the little sister!" Georgia cried when Allie and Maddy arrived at the luncheon. Allie's friends gathered around to greet Maddy. It was a nicer restaurant than Maddy had expected; small vases of flowers with name tags marked their places at the table. The other bridesmaids told Maddy that they were jealous because she was the only one wearing sky blue silk--they were all in almond-colored linen.
"Yes, but you'll be able to wear those suits for other occasions," Allie explained when her friends complained. "That's why I chose them. Maddy likes extravagant things."
True enough. The other women had noticed that Madeline was overdressed for the occasion; she was wearing a peacock-colored silk blouse and long silver and opal earrings. Well, people could think she was vain if they wanted to; it wasn't a crime to have good taste, after all.
"Maybe that's why she's never come here to see you before," Georgia guessed. "She's been waiting for the big dress-up occasion so she can show off."
"I haven't come because I work," Maddy said.
"And the rest of us don't?" Georgia wasn't one to back down.
"I didn't say that."
"You didn't have to. So what is it you do that keeps you so busy?"
"I'm an attorney," Maddy said.
The other women exchanged a look.
"Is there something wrong with that?" Maddy asked. "Some comment you'd like to make?"
"Well, she's here now," Allie said to her friends. "That's what's important."
All the same, there was a chill at lunch after that. Allie's friends were polite to Maddy, but no more. They discussed things she didn't understand, television series she'd never heard of, books she'd never read. She was once again, by choice or design, the outsider in her sister's life.
When she went to the lavatory, Georgia and Suzy were there. Maddy swore they shut up as soon as they saw her.
"So what's Paul like?" Maddy asked of the bridegroom-to-be as she washed her hands.
She definitely wasn't imagining it: Georgia and Suzy exchanged an odd glance in the mirror.
"Decide for yourself," Suzy said. She sounded extremely Texas, someone you wouldn't want to cross.
"You're her sister," Georgia added as she reapplied some lip gloss. "I'm sure you can make your own judgments."
"They didn't like me," Maddy said to Allie after lunch. Not that it mattered. She didn't care what people thought of her. She was like her grandmother in that way. She did as she pleased, no matter the consequences. She would have waded into a pond in Central Park if need be. Maddy and Allie had decided to walk home from the restaurant. It was spring after all. They cut through Hyde Park, which was so green they couldn't help but think of home, all of those reeds in the marsh, all those places to hide.
"Of course they liked you," Allie said. "Don't be so insecure."
No one else would have guessed Maddy was insecure. But Allie knew she had been a thumb sucker, a blanket holder, a little girl who had been frightened of spiders, afraid of the dark, terrified of mice. Allie would often have to crawl into bed beside Maddy and tell her a story before she could fall asleep. It was their story, the one about the heron, the one they had shared before Allie claimed it for herself and put it into a book.
"Paul will probably hate me, too."
From the Hardcover edition.
Meet the Author
ALICE HOFFMAN is the author of nineteen novels, two books of short stories, and eight books for children and young adults. Her work has been published in more than twenty translations and in more than one hundred foreign editions. She divides her time between Boston and New York City.
Brief Biography
- Hometown:
- Boston, Massachusetts
- Date of Birth:
- March 16, 1952
- Place of Birth:
- New York, New York
- Education:
- B.A., Adelphi University, 1973; M.A., Stanford University, 1974
- Website:
- http://www.alicehoffman.com
Customer Reviews
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Alice Hoffman is amazing. My seventeen year old daughter and I have read all her books. The Third Angel links lives of people through a hotel in London. Her words are so important that my daughter writes down some of the books thoughts on love and life. She gave us yet another gift to share- we both treasured this book. Although my favorite will always be Turtle Moon. My daughter's is Green Angel.
This book is amazing because you can read it over and over and always have a different perpective and notice something different. I love the style of this book because you can read the chapters completely out of order and still get the same overall appeal but in a completely different way. However, I will warn you that it might take a little to get started and it might be frustrating at first because it's a little hard to get into for the fact that you can read any chapter first and it will all make sense. The books characters aren't underdeveloped, but you'll see the need to jump from one person to another, to one timeline to another and so forth. It will all make sense and you'll be begging for more.
This is one of those mysterious hauntings that works backwards to solve the case of WHY. Wonderful puzzle pieces, complex, soulful characters, very believable, multi-faceted love,in the 1950's and 1960's time period, all to tantalize you and keep you reading till all hours of the night. ENJOY! WELL WORTH YOUR PURCHASE! Some others that took my very breath away...RAINWATER and EXPLOSION IN PARIS and BEAUTIFUL CREATURES...
I really enjoyed this book. It's a little hard to get into at first, but the simplistic writing style eventually got me engrossed in the story. My favorite section was the first part, "The Heron's Wife," but I felt that just as I was getting into it, the second section began and it started to get a little hard to keep track of all the characters and how everyone was connected. Maybe I liked the first part best because I have a sister and we're very close. The characters were well-developed, which makes it easier for the reader to understand their motivations. I liked that the book was not chronological, but I thought this technique was confusing. After I finished the book, I had to go back to the first section in order to understand the ending better. All in all though, this is a beautiful story about love and betrayal and I highly recommend it.
Once again, I have read an Alice Hoffman book with great admiration for her writing and her style, but find the story much too depressing. I love to read and continually have a store of books waiting in the wings and particularly enjoy great writers. However, I look to books as an escape from reality, not a chance to wallow in the miseries of others. This series of short but related stories is one disaster after another.
this book was set up weird because it included three seperate stories and while reading it i wasn't sure how they connected to eachother, but when i finished it it all clicked together to make an amazing story. Its unique and thats what makes it so great. THe storyline and characters are captivating and i didn't want it to end. overall it was a great book!
This book has an unusual writing style which keeps you reading well after you should be asleep. The characters were well portrayed, both adults and children. Emotions were very descriptive as well as the background to the story. I will be looking to see what else this writer has written, as her refreshing twist of writing captured my imagination.
I have enjoyed Alice Hoffman in the past but her books tended towards the depressing so I picked up this one hesitantly but fell in love with it. It's a wonderful story about the different ways people love one another. Her characters are complicated and humanly flawed. The story is so artfully written that it could be read backwards as well as forwards. I often pass along books to people when I am finished with them but this one is staying with me.
Alice Hoffman does not disappoint here...she delivers a quirky slice of life. Her characters are real.....the pain and joy they experience are your own as you weave through her story....wonderful
I haven't read all of Alice Hoffman's books, but I can easily say that this one is my favorite so far. Three-part plot, interweaving characters, tense story line, realistic emotions and dialogue. A little bit mysterious and special. If you like Hoffman you will love this book.
This book was incredibly moving and quite unforgettable. There were several times I could feel the pain and love right alongside the characters. I became so involved with the characters that I was sad to see the book end. This was this first book I read by Alice Hoffman, and the day I finished the book I went to the store and bought two more of her books. I can't wait to read them!
This offering by Ms. Hoffman is a generational piece whose roots are in the 1950s. The backdrop for most of the story is the Lion Park hotel in London, a second-rate hotel that is haunted. Our first encounter with sisters Maddie and Allie uncovers a betrayal by the younger sister who lives a care-free existence based on the fact that she believes that she was an unloved child. Allie, the older sister, has pretty much done what was expected of her because she has always been the caretaker; first when her mother had cancer and later when her fiance suffers from the same disease. She realizes only too late that she truly loves her fiance and moves swiftly to makes things right only to lose him too. Freida, the fiance's mother, takes up the middle of the book. Her story is set in the 1960s and brought back for this reader 'the look' that was so popular then in London: overly made-up eyes, short mini-skirts, high boots, swingy music, free love, etc. Hoping to escape from the dreariness of a rural youth she makes her way to the Lion Park hotel where she works as a maid. Soon, though, she becomes the muse for a rock-star wanna-be who is hooked on drugs and has a very Paris Hilton-like girlfriend. In the end, Freida puts all of the very trendy and drug-filled life behind her and returns to her rural home where she marries the boyfriend who had gone on to college. She goes on to nursing school herself and lives a very fulfilling life in spite of the ghostly happenings that populated her time working at the Lion Park. The thread that sews it all together is Lucy Green. Lucy is the mother of the two young women we first met at the outset of the story. Inadvertently she is the one who caused the problems that have brought about the haunting of the Lion Park's seventh floor. Having witnessed the deaths of the people involved she withdraws to a secret place inside herself just as she did when her own mother passed away. It takes love in all its simple complexities to bring Lucy into her own once more. This book is a very easy read despite the complexities of the characters we meet. I read it in two sittings and would have accomplished it in one had I not fallen asleep at nearly two in the morning. I give this story four stars simply because I've enjoyed some of Ms. Hoffman's other offerings more. Note: you're bound to fall in love with Millie.
this is just a wonderful and lovely book filled with beloved people like everyday life. What sets it apart, however, is how the writer approaches each individual's struggle and brings them together in the end. I highly recommend it.
If you're an Alice Hoffman fan, this book will not disappoint you. Once again she is able to tell a story, bring her characters alive with feeling, and touch our souls. So simple, and yet so heartful, and mystical.
Satisfaction Guaranteed!! A beautifully written story. Definitely one of Alice's best. You will love the characters that are so real and vunerable. What a boring place my world would be if I could not read the amazing words of Alice Hoffman.
I can't believe how quickly I was able to finish the book. It's only been two or three days. Once I started, I didn't want to put it down, literally. Out of the three sections of the book, my favorite was the last part, where the author reveals the whole story of "Michael Macklin" who is the main story line throughout the story. I love the part where "Lucy cried, but no one was listening to her. She was invisible. She was watching a dream." The author describes how helpless she is in the situation. When Teddy Healy came and had the fight with Michael, the whole pace of the book starts to get faster and faster. Her descriptions are so captivating at that part, (I think it is the climax) my heart starts racing. Sadly, it still has a bad ending... "Michael had looked at her from the other side of the road. He had focused for one moment as though he was glad they saw each other and recognized each other. Then he stepped off the pavement like a man jumping off a bridge, as calm as a simmer with an ocean out below. Lucy had known he was going to do it the instant their eyes met. She'd known what he intended because she would have done the very same thing if she'd had his courage. Nothing was going to break his fall." When a car kills Bryn, Michael too chooses to end his life. Perhaps like Lucy say, they'll be in heaven together, and there, their love that was disapproved by of everyone would finally be concern eternal. The first two parts of the book, which are earlier in time, were a rumor that in the hotel room is Michael's ghost. But in the last chapter, it reveals that the one trapped inside the room was Teddy's soul that had broken from his body the moment he saw his beloved with someone else. That is really fascinating! Just like Chicago Tribune's book review, "This is a strong, visceral and deeply, darkly moving tale of love and heartbreak, tragedy and redemption..." I don't have a strong vocabulary, so all I can say is this book is stunning and I was moved!
I have mixed emotions about The Third Angel. It is actually three short stories that become threaded and connected at the end. It is basically a story of love and life. If we are honest, love (and life) can sometimes be unconventional - which is how I felt about the storylines. Sometimes we don't choose who we are going to fall in love with, life and circumstances have a way of bringing two hearts together. This story dabbles in disappointments, hidden secrets, the heartaches that come with guilt and regret and all wrapped nicely with a bit of spirituality. Three stories, one hotel, three loves, one angel. I'll not go into the premise of each story, you can read the stories synopsis and figure it out for yourself, but basically it deals with the theory that there are three types of angels. There is the Angel of Life, the Angel of Death and then there is the third angel -- the one who walks among us. The book was well written, rich in descriptive scenery, but for me I just felt something lacking. I can't put my finger on it -- perhaps it was because all of the stories seem to have a not-so-happy ending; they were full of people hurting and living in the past and pain. For me the most positive takeaway I received from the book was in the life of the doctor who met everything in life with an open mind and accepting attitude of "Well, what have we here?" Don't let my less than enthusiastic thoughts of the book discourage you from reading it -- perhaps it just didn't work for me.
A little boring however it is a about the wonders in life so it a little interesting.
This book was so heart warming at times and yet heart breaking at times. The relationship between the characters was so intriguing
interesting intertwining of stories-i loved it!


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Director of Rugby Ruddock admits his team have no time to dwell on defeat in Stockport last Friday and are now fully focussed on the visit of the Exiles.
And he has appealed on fans to once again pack out Sixways to make home advantage count in the closing weeks of the season.
"Even though we lost at Sale you weren't looking at a Worcester Warriors side that was lacking spirit, that was not united or up for the fight," he said.
"We have been in these situations before, it is not something we are particularly proud of but we are used to picking ourselves up, dusting ourselves down and getting on with it.
"The boys are disappointed, but we don't dwell on it and the fact we lost. We look at London Irish and how we can beat them.
"The squad is composed and mindful that we have three home games to come and an away game to our nearest rivals. It will be tough but ultimately this league is about winning your home games.
"We have to take advantage of our great crowd and great stadium, get the fans behind us and roaring us on. Once we do that I am sure we will perform," he added.
"It does make such a difference to have the crowd behind us. They have been our 16th man and given us that extra man.
"Against Leicester, for an hour, I thought we looked a top of the table team and they struggled against us.
"If you look at what they did to Bath at the weekend, it just shows that they can do that to any team and for an hour we looked right on top of them. We feel we are still a good team and we have to look to make that count."
Tickets remain on sale to watch Warriors tackle London Irish this Saturday at Sixways Stadium. Call the Warriors Box Office today on 01905 454183 or visit the online Tickets section by clicking HERE

subset: commoncrawl


text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The potent mitogenic toxin from
Toxinogenic strains of
Intoxication of mammalian cells by PMT activates a number of different intracellular calcium, cytoskeletal, and mitogenic (MAPK and JAK/STAT) signaling pathways (reviewed in [
Although the intracellular action of PMT is becoming more defined [
The small GTPase Arf6 is involved in trafficking of ligands from the plasma membrane and localizes both to the plasma membrane and to internal punctate structures. Intra-endosomal acidification has been shown to result in recruitment of Arf6, along with its cognate GDP/GTP exchange factor (GEF) and an ADP-ribosylation factor nucleotide site opener (ARNO), to the endosomal membrane [
Transferrin (Tfn) and its cognate receptor are ubiquitous iron-uptake proteins that are well-characterized markers for Rab5-containing clathrin-coated vesicles and recycling endosomes [
Cholera toxin (CT), a multi-subunit protein toxin secreted by
Although we hypothesize that PMT shares a common initial entry pathway with CT, CT has a KDEL signal and undergoes further retrograde trafficking through the Golgi to the endoplasmic reticulum (ER), where the catalytic subunit of CT escapes to the cytosol [
Our studies reported herein aim to elucidate the trafficking events involved in PMT intoxication. In particular, we describe the role of the small GTPase Arf6 in the uptake and trafficking of PMT. Furthermore, we show that PMT shares the same initial pathway for entry into the cell as Tfn and CT, but then the PMT trafficking pathway diverges from the others to a late-endosomal compartment, from which PMT then translocates in a pH-dependent manner.
The pcDNA3.1 vector encoding the wild-type Arf6 protein was obtained from the Missouri S&T cDNA Resource Center. pcDNA3.1-Arf6 T27N, pcDNA3.1-Arf6 T44N, pcDNA3.1-Arf6 Q67L, pcDNA3.1-Arf6 T157A, pcDNA3.1-Arf6 G2A/Q67L, and pcDNA3.1-Arf6 G2A/T157A mutants were created by a two step PCR with the first step introducing the mutation and a second step amplifying the entire cDNA using the primers listed in
Primers used in construction of Arf6 mutants.
|Primer Name
|Sequence (5' to 3')
|Arf6 T27N
|Arf6 T27Nr
|Arf6 Q67L
|Arf6 Q67Lr
|Arf6 Q67L 2
|Arf6 Q67Lr 2
|Arf6 T157A
|Arf6 T157Ar
|Arf6 G2A
|Arf6 G2Ar
Recombinant PMT (rPMT) was expressed and purified as previously described [
HEK 293-T cells (ATCC # CRL-11268) and Swiss 3T3 cells (ATCC # CCL-92) were cultured and maintained at 37 °C and 5% CO2 in DMEM (Gibco) with 10% fetal bovine serum (FBS), 100 U/mL penicillin G, and 100 µg/mL streptomycin.
HEK 293-T cells at 80% confluency were replated at a 1:7 ratio in 24 well plates. The next day the medium was changed to DMEM with 2% FBS, penicillin and streptomycin, and cells were transfected using the CaCl2 method [
SRE activity was determined by dividing the firefly luciferase activity by the
HEK 293-T cells at 80% confluency, maintained as described above, were plated at a 1:7 ratio in 24-well plates. The next day the medium was changed to DMEM with 2% FBS, penicillin and streptomycin, and cells were transfected using the CaCl2 method, as described above. Each well was transfected with 250 ng/mL of pSRE-
HEK 293-T cell lysates were subjected to western blot analysis. Lysates were separated on a 10% SDS-PAGE acrylamide gel and subsequently transferred to a nitrocellulose membrane. Membranes were blocked for 30 min at room temperature in 5% powdered milk in 10 mM Tris-blocking buffer (10 mM Tris-HCl, pH 8.0, 2 mM EDTA, 50 mM NaCl, 0.1% NaI). Membranes were then incubated overnight at 4 °C with the indicated primary antibody in 5% milk in 10 mM Tris-blocking buffer. Membranes were then washed 5 times for 3 min in 1% Tween in 100 mM Tris-washing buffer (100 mM Tris-HCl, pH 8.0, 200 mM NaCl) before incubation at room temperature with the appropriate secondary antibody. The following primary antibodies were used: mouse anti-phospho-Akt (Ser473) 587F11 (4051, Cell Signaling) and mouse anti-Akt (9272, Cell Signaling). HRP-conjugated secondary antibodies used included: goat anti-mouse IgG (115-036-003, Jackson ImmunoResearch Laboratories, Inc.) and goat anti-rabbit (sc-2004, Santa Cruz Biotechnology). After washing 5 times for 3 min each with Tris-washing buffer, the membranes were then developed using Pierce® ECL Western Blotting Substrate (Thermo Scientific) and HyBlot CL autoradiography film (Denville Scientific Inc.). Images were then scanned and prepared using Adobe Photoshop. Blots shown are representative of at least three independent experiments.
Swiss 3T3 cells at 80% confluency were plated in a 1:12 ratio on 18mm circular coverslips (Fisher) in 12 well plates containing DMEM with 1% BGS. The next day the medium was changed 3–4 h before toxin treatment. If chemical inhibitors were used, medium containing the indicated inhibitor, final concentration of 30 mM NH4Cl or 1 µM BFA, was added to the wells 15 min before toxin treatment. After 15 min incubation with the inhibitor, PMTb-GFP was added to the wells at a final concentration of 100 µg/mL. CT subunit B Alexa Fluor®-594 conjugate (CTxB-594) (Molecular Probes) was added to the wells at a final concentration of 1 µg/mL. After 1 or 3 h of toxin treatment the medium was removed and the coverslips were fixed with 3.7% formaldehyde in DMEM 10% BGS for 20 min. Coverslips were washed 3 times with 1× PBS and mounted onto a No. 1 ½, 22 × 50 mm coverslip (Corning) using ProLong Gold mounting media (Invitrogen). Confocal microscopy was carried out with a Zeiss LSM 710 NLO (Zeiss). Images were generated as described above.
Swiss 3T3 cells were plated at low density (103 cells per well) on coverslips in a 12-well plate and grown overnight in 10% BGS-DMEM. Before toxin treatment, the cells were washed 2 times with 1× PBS containing gentamicin and PMTb-GFP was added to the wells at a final concentration of 100–260 μg/mL of PMTb-GFP. After 15-h incubation, 20 μg/mL of Transferrin-Texas Red (Tfn-TR) was added to each well and incubated for an additional 3.5 h. Toxin treatment was terminated by washing the wells with 1× PBS and fixing the cells with 3.7% formaldehyde in PBS. Coverslips were washed 3 times with 1× PBS and mounted using mounting medium consisting of 1× PBS, 180 mg/mL polyvinyl alcohol (PVA), 27% glycerol and 2 g/L DABCO anti-fade reagent (1,4-diazabicyclo-[2.2.2]octane). Confocal microscopy was performed using a Carl Zeiss Laser Scanning Microscope (LSM 510) with a 40× oil-immersion objective. Images were generated as described above.
A number of bacterial toxins are internalized via receptor-mediated endocytosis, yet the precise pathway taken varies among the different toxins. To determine which pathway is utilized by PMT, we first sought whether PMT is internalized via the same pathway as Tfn, which traffics primarily through Arf6-positive early endosomes [
PMTb-GFP initially colocalizes with Tfn-Texas Red, but then diverges and is trafficked to endosomes through a PI3-kinase-independent process. Shown are confocal microscope images of Swiss 3T3 cells after treatment with PMTb-GFP, with the endosomes marked by Transferrin-Texas Red (Tfn-TR). Cells were treated with 260 µg/mL PMTb-GFP and with 20 µg/mL Tfn-TR for 3.5 h to visualize the endosomes. Cells were visualized by confocal microscopy using a 40× objective. (
PMTb-GFP initially colocalizes with CTxB-594, but then diverges and is trafficked to and translocated from acidic endosomes. HEK 293-T cells were transiently transfected with dual SRE-luciferase reporter plasmids and pcDNA3-Gαq as described in Methods. Seven h post-transfection cells were treated with (
It has been previously demonstrated that Arf6 is implicated in internalization of Tfn [
Weak bases such as NH4Cl can be used to alkalinize endosomal pH [
In contrast to PMT, intra-endosomal acidification does not play a role in entry and translocation of CT [
Arf6-dependent internalization and trafficking of PMT. HEK 293-T cells were transiently transfected with dual SRE-luciferase reporter plasmids, pcDNA3-Gαq, and plasmids containing Arf6 or Arf6 mutants, as described in Methods. Seven hours post-transfection cells were treated with 100 ng/mL PMT and incubated for 15 h before assaying for SRE reporter gene activity. SRE fold activation was determined by dividing SRE reporter gene activity in PMT treated cells by SRE reporter gene activity in untreated control cells. Fold activation was then normalized to empty vector control (pcDNA3). Data is expressed as an average of eight experiments ± S.D., with each experiment performed in triplicate, where *
Previous studies show that intra-endosomal acidification by the V-ATPase results in recruitment of the small GTPase Arf6 and its GDP/GTP exchange factor (GEF) ADP-ribosylation factor nucleotide site opener (ARNO) to the endosomal membrane [
To investigate the role of Arf6 in PMT trafficking, we overexpressed wildtype and several mutants of Arf6 to observe their effects on rPMT induced SRE-luciferase reporter activity. Arf6 is a small GTPase that relies on hydrolysis of a bound GTP and subsequent release of GDP to function properly. Therefore, any Arf6 mutants that have defects in GTP hydrolysis and subsequent GDP release will have impaired activity. The Arf6 Q67L mutant is a constitutively active mutant, while the Arf6 T27N and Arf6 T44N mutants are dominant-negative mutants. The Arf6 T157A mutant is constitutively cycling due to decreased binding of both GDP and GTP.
Overexpression of wildtype Arf6 had no effect on PMT-induced SRE-luciferase reporter activity in HEK 293-T cells treated with rPMT (
Next we wanted to determine if the effects of overexpression of Arf6 mutants on rPMT activity were dependent on the trafficking activity of Arf6. It was previously demonstrated that mutating the glycine at position 2 of Arf6 to alanine results in a cytosolic, nonmyristolated Arf6 that does not associate with membranes and is unable to mediate endocytic trafficking [
To explore whether PMT may exploit a similar Arf6-dependent pathway for initial entry as CT [
We next wanted to determine whether components of the cytoskeleton are important for PMT entry and trafficking. We hypothesized that if actin dynamics play a prominent role in trafficking and internalization of PMT, pre-treating cells with cytochalasin D, an inhibitor of actin polymerization, would interfere with PMT trafficking pathways thereby inhibiting rPMT-induced SRE-luciferase reporter activity. To determine whether actin dynamics play a significant role in trafficking and internalization of PMT, HEK 293-T cells were pre-treated with varying concentrations of cytochalasin D for 15 min before rPMT treatment. As shown in
Microtubules are required for trafficking from early sorting endosomes to late acidic endosomes [
Both actin and microtubule dynamics are important for PMT trafficking to translocation-productive acidic late endosomes. HEK 293-T cells were transiently transfected with dual SRE-luciferase reporter plasmids and pcDNA3-Gαq as described in Methods. Seven h post-transfection cells were treated with cytochalasin D (
Brefeldin A (BFA) is a fungal metabolite that interrupts trafficking between the Golgi apparatus and the ER, leading to the accumulation of secretory proteins in the ER [
We further explored this phenomenon by determining whether translocation of PMT from the endosome was necessary for the observed BFA-mediated increase in PMT activity. We hypothesized that if translocation from the endosome were necessary for the BFA-mediated increase in PMT activity, blocking translocation of PMT into the cytosol by treating with NH4Cl to prevent acidification of the endosome would effectively inhibit PMT activity. To test this possibility, HEK 293-T cells were pre-treated for 15 min with both 1 µM BFA and varying concentrations of NH4Cl up to 20 mM. As shown in
We then attempted to elucidate the mechanism of this BFA-mediated increase in PMT activity by determining whether this effect was occurring downstream of the Arf6 involvement in PMT trafficking. We first overexpressed in HEK-293T cells the Arf6 mutants, Arf6 Q67L or Arf6 T157A, which we found to decrease PMT activity by preventing PMT entry and trafficking (
Next, we determined the localization of PMTb-GFP and CtxB-594 in cells pretreated with BFA. Swiss 3T3 cells were pretreated with 1 µM BFA for 15 min and subsequently co-treated with PMTb-GFP and CtxB-594 for 3 h, after which the cellular distribution of the toxin proteins were visualized by confocal fluorescence microscopy (
This study further defines the trafficking pathways PMT uses to gain access to its intracellular targets. Previous studies showed that PMT inserts into lipid membranes and that this membrane insertion is pH-dependent [
Treatment with brefeldin A enhances PMT activity. HEK 293-T cells were transiently transfected with dual SRE-luciferase reporter plasmids and pcDNA3-Gαq as described in Methods. Seven h post-transfection cells were treated with brefeldin A (BFA) at the indicated concentrations (
It has been demonstrated that intra-endosomal acidification recruits the small GTPase Arf6 to the endosomal membrane [
Overexpression of the dominant-negative mutant of Arf6, Arf6 T27N, results in accumulation of the mutant Arf6 in tubulovesicle structures [
Membrane localization of Arf6 is mediated through its
As previously mentioned, Arf6 is not only an allosteric activator of CT [
Given the evidence that PMT, Tfn and CT diverge in their trafficking pathways, we wanted to further explore the trafficking pathways of PMT downstream of Arf6. Other toxins, such as DT, that exhibit a dependence on intra-endosomal acidification for translocation [
Not only have we shown that PMT is trafficked through a compartment with Arf6, we have also demonstrated the importance of the cytoskeleton in these trafficking pathways. Our results indicate that PMT trafficking is dependent upon both actin and microtubule dynamics, implicating both actin and microtubules in the trafficking pathways that PMT uses to enter the cell. To further investigate where the PMT and CT trafficking pathways diverge, we investigated the effects of brefeldin A (BFA) on PMT-mediated SRE-luciferase activity. BFA is a fungal metabolite that interrupts trafficking between the Golgi apparatus and the ER and causes accumulation of secretory proteins in the ER [
Our colocalization experiments demonstrated that, unlike CTxB-TR, PMTb-GFP was not trafficked to the ER. If PMTb-GFP were not trafficked to the ER, then BFA treatment would not be expected to affect PMT-mediated SRE-luciferase activity. However, we saw an increase in SRE-luciferase activity when cells were treated with BFA. Interestingly, VacA from
However, other data suggests that while the morphology of the endosomal system is changed by BFA, cycling between the early endosome and the lysosome is not impaired [
Alternatively, perhaps BFA treatment is responsible for increasing the number of PMT cell surface receptors. It has been shown that treatment with BFA increases the amount of cell-surface associated mannose-6-phosphate receptor (M6PR) [
By overexpressing the Arf6 Q67L mutant that inhibited endocytosis, we were able to block the effects of BFA. This would suggest that the BFA mediated increase in PMT activity depends on PMT initially entering the cell. In addition, we showed that treating the cells with NH4Cl blocks the BFA mediated increase in PMT activity, indicating that translocation is necessary for this BFA-mediated increase in PMT activity. These results support the assertion that the increase in SRE-luciferase reporter activity after treatment with BFA is dependent on the ability of PMT to enter the cell via endocytosis and to translocate from the endosome.
In summary, we have implicated the Arf6 trafficking route as a potential mode of entry for PMT. A model of PMT entry and trafficking that incorporates our findings as well as previous findings is shown in
A model of PMT entry and trafficking. PMT enters the cell through an Arf6-dependent endocytic pathway that involves both actin and microtubule dynamics as evidenced by inhibition of PMT-mediated SRE activation upon expression of Arf6 mutants (Arf6-CA or Arf6-DN) or treatment with the inhibitors cytochalasinD (CcD) or nocodazole (Noc), respectively. PMT shares a similar route of endocytosis as transferrin (Tfn) and cholera toxin (CT); however, these pathways subsequently diverge. Tfn-bound receptors are trafficked to a Rab5-containing endosome in a PI 3-kinase-dependent vesicle fusion process, which is inhibited by LY294002. CT is trafficked retrograde through the trans-Golgi network (TGN) to the Golgi-ER. PMT is further trafficked through an endocytic vesicle that becomes acidified prior to translocation of PMT to the cytosol. Inhibitors of endosomal acidification, such as NH4Cl and bafilomycin A1 (BafA1), block the translocation of PMT, while brefeldin A (BFA) enhances this process by diverting any trafficking of PMT to the TGN instead to the acidified endocytic vesicles.
This work was supported by NIH/NIAID grant AI038395 (to B.A.W.). We are grateful to Leila Aminova for technical assistance with preliminary studies, and to Brent Beenders and Mayandi Sivaguru for assistance with confocal microscopy. We also thank Jie Chen for the anti-P-Akt and anti-Akt antibodies and helpful discussion.


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text: The Yummiest Gluten Free Resurrection Rolls Ever (dairy free, soy free, egg free, gluten free) (I used raw sugar instead of brown sugar.) I'm so excited! I finally have a gluten free, dairy free, soy free, egg free, nut free Resurrection Roll Recipe that tastes GREAT! This is completely yummy even for kids that aren't […] Read more »


text:
Nevada Struggles in Second Half, Loses to Boise State, 34-17
Wimberly leads team with 11 catches for 121 yards.
Fajardo Shines as Blue Tops Silver in Spring Game
Great crowd on a beautiful day at Mackay Stadium
Nevada Has 37 Student-Athletes on 2012 Fall Academic All-Mountain West Team
League-record 409 student-athletes on the 2012 fall team
Fajardo, Nevada Run Past New Mexico, 31-24
Nevada's Cody Fajardo threw three touchdown passes and ran for a career-high 186 yards Saturday to help the Wolf Pack beat New Mexico 31-24 and end a three-game losing streak.
Nevada Opens 2012 Campaign At Cal
Wolf Pack's season opener is Saturday at newly renovated Memorial Stadium in Berkeley.
Stephen Jeffers talks to the media
Stephen Jeffers talks to the media following the Wolf Pack's win over New Mexico.
2013: Enters junior season as the top blocking tight end on the roster and will compete for a starting job along with Kolby Arendse.
2012: Played in all 13 games with no starts ... Caught two passes on the year, including his first career touchdown, a 1-yarder at New Mexico.
2011: Played in 12 games and served primarily as the blocking tight end in the Wolf Pack's Pistol offense ... First career catch came at Oregon and was good for 16 yards ...Second catch of his career was for six yards against UNLV.
2010: Played in a handful of games as a backup tight end behind All-WAC selection Virgil Green and Zach Sudfeld ... Did not catch a pass.
2009: Redshirted his first season in the program but made the travel squad for the Sheraton Hawai`i Bowl.
High School
A graduate of Bishop Manogue Catholic High School in Reno, Nev. ... Was an all-around standout athlete, lettering in five sports: football (twice), basketball, baseball, wrestling and track and field ... Helped football team to a league championship as a senior ... Was the Northern 4A Lineman of the Year as a senior while earning first-team all-region and all-league accolades ... As a junior, was first-team all-league and second-team all-region ... Was part of a league-champion baseball team in 2008 ... Was first-team all-league and all-region in track and field as a senior ... Graduated with high honors and was a National Honor Society member.
Born James Stephen Jeffers on Nov. 30, 1990 in Truckee, Calif. ... Son of Jim and Shelli Jeffers ... Has a younger sister, Samantha and a younger brother, Michael ... Has not yet declared a major ... Was also recruited by Fresno State, UNLV, SMU, San Diego State and Montana ... Chose Nevada to stay close to his family ... Father played football at San Diego State ... Uncle, Walt Brett, played football and Montana and in the NFL with the Falcons and Chargers ... Aunt, Lisa Robinette played basketball at Washington State ... Uncle, Michael Mariani, ran track and field at Arizona State ... Grandfather, Mike Mariani, played football at Arizona State.
Career Stats:


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Type of Document Master's Thesis Author Witcher, Joseph Brandon Author's Email Address firstname.lastname@example.com URN etd-02112003-215228 Title Methodology for Switching Characterization of Power Devices and Modules Degree Master of Science Department Electrical and Computer Engineering Advisory Committee
Advisor Name Title Boroyevich, Dushan Committee Chair Lai, Jason Committee Member Odendaal, Willem Gerhardus Committee Member Keywords
- switching characteristics
- power module
- power MOSFET
Date of Defense 2003-01-29 Availability unrestricted AbstractIn modern power electronics systems there is a growing trend to replace discrete devices with integrated power electronic modules (IPEMs). In this way, several components can be replaced by a single component. By using prefabricated building blocks, the engineer simplifies the design process, reducing the total design cycle time and cost. By integrating only the necessary components to provide power switching, the end user has a pre-optimized building block with the flexibility to be used in a large variety of applications.
Besides simplifying the design process, power modules should be designed in such a way as to improve the performance of the power converter. This begs the question as to how best to judge if one IPEM has better performance than another or better performance than its discrete counterpart. In analyzing a converter's performance, popular criteria include efficiency, power density, device stresses, and EMI. All of these criteria are strongly linked to the switching characteristics of the IPEM's power devices.
This thesis is a comprehensive study of the requirements for obtaining and analyzing the switching characteristics of the IPEM's power devices. It outlines the important switching characteristics and the implications of each characteristic on converter performance. It deals with the relevant measurement issues, specifically addressing the minimum requirements, which sensors are most suitable, and problems leading to inaccurate data. A parametric study is conducted to determine the effects of several circuit and operating parameters on the switching characteristics. Using the resulting data and the knowledge from the measurement study, we can decide how to design the testbed layout, what operating conditions should be chosen for testing, and what effects of the tester must be decoupled to truly see the effects of IPEM design. The thesis concludes with the design of standard test equipment and procedures.
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Gun Fighters, Lawmen, Outlaws A colorful piece of the American West was the gunfighters, lawmen and the outlaws still glamorized today in the movies
Notorious Gangs :
James Gang Frank James Notorious Outlaw Gunfighter and Jesse James Outlaw Gunfighter ran the famous James Gang Robbing Banks, Trains and Stagecoaches
Wild Bunch Gang of Out Law, Gunfighters, Bank and Train Robbers
Famous Gunfights :
O.K. Corral Lawmen Morgan, Virgil, Wyatt Earp and Gun Fighter Friend Doc Holliday being on one side and on the other side were Would-be Gunfighters Ike and Billy Clanton, Tom and Frank McLaury, Billy Claiborne, and Gunfighter Wes Fuller
Gun Fighters :
William Bonney Gunfighter and Vicious Outlaw
John (Doc) Holliday Friend of Lawmen Gambler Extraordinary and Gunfighter
Billy the Kid Gunfighter Outlaw with Numerous Aliases
Hideouts :
Hole in the Wall Provided refuge for notorious Gunfighters and Outlaw gangs
Lawmen :
Wyatt Earp Lawman Gunfighter
Pat Garrett Famous Lawman Gunfighter
James Butler Hickok Gunfighter sometimes Lawman
William Barclay Masterson Buffalo Hunter, Army Scout, Gunfighter, and Lawman
Occupations :
Buffalo Hunters Gunfighters, Lawmen and Outlaws,were Buffalo Hunters
Cattle Rustlers Lawmen brought Cattle Rustlers to Court. Cowboy Justice was at the end of a rope at the Closest Hanging Tree
Horse Thieves and Lawmen. Seldom Make it Past the Closest Hanging Tree
Stagecoach Drivers and Shot Gun Guards to Discourage Outlaws
Train Robbers The Trains Were Slow and lawmen scarce
Outlaws :
Alexander Franklin James Outlaw Gunfighter from the James Gang
Jesse James Outlaw Gunfighter from the James Gang
Harry Longbaugh (Sundance Kid)Outlaw Gunfighter from the Wild Bunch
Robert Leroy Parker (Butch Cassidy)Outlaw Gunfighter from the Wild Bunch
Outlaws Victims :
Concord Stagecoach had Lawmen Riding Shotgun guarding against Outlaws
Union Pacific Railroad Wooden Mail Cars Often Were Blown Up by Outlaws
Wells, Fargo and Company Hired Lawmen Good Gunfighters as Detectives to Catch Outlaws
Legal, ©1999 American Western History Museum, Policy page


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STARmeterSEE RANK
Down 424 this week
Gérard Blain (1930–2000)
Gérard Blain was born on October 23, 1930 in Paris, France. He was an actor and director, known for The American Friend (1977), Hatari! (1962) and Le beau Serge (1958). He was married to Monique Sobieski, Bernadette Lafont and Estella Blain. He died on December 17, 2000 in Paris. See full bio »
Born:in Paris, France
Died:(age 70) in Paris, France


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WASHINGTON (Jul. 25)
The Reagan Administration stressed today that no decision will be made before next fall on requests by Jordan and Saudi Arabia to buy sophisticated American arms. "Both Jordan and Saudi Arabia have informed us of their current defense needs and these remain under review," State Department deputy spokesman Charles Redman said.
He reiterated that the just completed Administration study on how Middle East arms sales fit into U.S. policy does not recommend any specific sale. He said the study, which is being shown to Congressional committees on a classified basis was not "a decision" paper but "a document which contains the framework on which decisions can then be made."


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Dave Spencer Answers the Call, Donates Blood at Walmart Blood Drive [VIDEO]
I've been a regular blood donor for about 4 years. I try to give every two months. But I've been fortunate on the occasions I've forgotten, because I've received phone calls at those times informing me of a shortage of O negative blood, the universal blood type. And, yes, that makes me a universal donor. I got such a call yesterday and went to the blood drive at Walmart on South Frederica to donate today. If you'd like to give the gift of life by donating blood, visit the Western Kentucky Regional Blood Center at 3015 Old Hartford Road in Owensboro. The Center is open Monday, Wednesday, and Thursday from 8:30AM to 5:30PM; Tuesday from 8:30AM to 8PM; Friday from 8:30AM to 4:30PM.
Subscribe to WBKR-FM on


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Heated Panty Liners: Brilliant Method For Easing Period Pains Or Weird Way To Set Your Vagina On Fire?
Those of us with with a uterus know what it's like to be desperate for a heating pad to ease the writhing, stabbing pain from menstruation cramps. It turns out, we could go for a little more relief directly at the source — by way of Korea, there now exist heated panty liners. The blog British Beauty Blogger posted pictures of the pad, which her friend picked up on a trip to Japan. She said the package contains a "heated sachet," which gets very hot and is not to be worn "directly in contact with your nethers." I guess it's not so much a "heated panty liner" as a heated object you wear it underneath a panty liner? Either way, the whole concept of a heated panty liner seems similar to stuffing those handwarmers that people put in their mittens down your panties.
If any Frisky readers speak Korean, I would love a translation on the packaging of what I think are the suggested uses for a heated panty linter because half of them don't make any sense from the pictures. Skiing? Sitting on a chair? Holding a baby? I don't even want to risk any burns on my vag and/or inner thighs, so my only suggested use is laughing at this. [British Beauty Blogger] [Images via British Beauty Blogger]


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Tuesday, Aug. 5, 2014 | 9:52 p.m.
More Coverage
Rafael Montero pitched a one-hit shutout over eight innings today for the Las Vegas 51s in a 3-0 victory at Sacramento.
The lone hit Montero surrendered was a fifth-inning single to Sacramento's Nick Buss, striking out 11 batters and walking just two. Reliever Chase Bradford struck out the Sacramento side in the ninth inning to earn the save.
Las Vegas (66-53) scored a run in the first and second innings. Matt den Dekker and Matt Reynolds had consecutive singles to open the game for Las Vegas, and den Dekker scored to give the 51s a 1-0 lead on Allan Dykstra's sacrifice fly.
In the second, Kevin Plawecki scored on Anthony Seratelli's groundout.
The 51s are off Wednesday. They return to Cashman Field at 7:05 p.m. Thursday for a four-game series with Albuquerque.


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He now serves as chairman and CEO of Alcoa Inc. and once headed the giant German firm siemens.
He waged war on the modern with a siemens dialysis machine in-tow, bankrolled by Aramco petrodollars.
The current energy and industrial boom, according to siemens President Joe Kaeser, "is a once-in-a-lifetime moment."
Yet it seemed to target only siemens computers at the Natanz facility involved in enriching uranium.
Similar incentives convinced siemens to expand its wind turbine factory in Fort Madison Iowa.
Direct arc-heating furnaces, as exemplified in the siemens crucible furnace mentioned above.
As in siemens' experiment, the motor was of the same construction as the dynamo.
For elevated railways Messrs. siemens and Halske a long time ago chose rails as current conductors.
Edison and siemens are the spiritual fathers of Bellamy and Bebel.
In some of siemens's cables, vulcanised india rubber replaces the gutta percha insulation.
siemens sie·mens (sē'mənz)
n. pl. siemens
A unit of electrical conductance in the International System of Units, equal to one ampere per volt.
Plural siemens
See mho.


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Zombie School Boy CostumeItem #: 24636
Add the product directly to your basket by clicking the checkbox
Zombie School Boy Costume
Creepy school uniform as a Halloween disguise for Kids
For Zombie Walk is this zombie schoolboy costume really excellent, because that can then equal to a whole class dress up as the undead, and send through the towns.The Zombie Child Costume is also a hit at any Halloween party!
The Zombie School Boy Costume is a 3-piece costume set and includes besides jacket with shirt and a pair of pants and a tie.The long pants school uniform is gray, torn, provided with scraps on the waistband and stained with blood stains.An elasticated waistband ensures a comfortable fit.The also gray Zombie jacket has short sleeves, is also bloody and frayed and has a sewn, bloody shirt, which is provided at the front with three plastic knobs.Fully is the schoolboy costume with red and black striped tie, which is held by an elastic band.In keeping with the zombie schoolboy costume, there is the Zombie Schoolgirl Costume and the creepy Zombie Make Up Set ,
1 x Zombie School Boy Costume
- Content: Pants, jacket with shirt, tie (socks and shoes not included.)
- Colour: gray / white / red
- Material: 100% Polyester
- Gruesome school uniform of a young Zombies
|L ca.10-12 years
|Teenage boys 13+
|approx. 76-80 cm
|approx. 79-91 cm
|Waist circumference
|approx. 64-67 cm
|approx. 67-80 cm
|approx. 145-158 cm
|approx. 152-168 cm
Warning: Not suitable for children under 3 years.Contains small parts that can be swallowed.Keep away from open flames.,


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By Lifestyle
Before After
Run a Marathon.
Get Steamy Till dawn.
We've got you covered.
Whether it's a news anchor's scar or a volleyball player's vitiligo, whatever your coverage need, camouflage it flawlessly.
Complete The Routine
How to apply
- 1 Remove a small amount of Cover Creme.
- 2 Heat the product with your fingertip to allow the creme to soften which will allow the product to become more blend-able.
- 3 Apply directly over imperfection. Use a tapping motion to ensure coverage.
- 4 Allow foundation to dry before applying additional layers, if more coverage is needed.
- 5 Apply a generous amount of Setting Powder, allow to set for 2 minutes then brush off excess powder with a brush.


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Some of you may have played The Sense of Connectedness, an abstract puzzle game which I posted on a few forums and tweeted about.
It is not my game. I had absolutely nothing to do with its development, apart from a bit of beta testing.
Michael Brough, developer of the upcoming Vertex Dispenser, solely and fully developed The Sense of Connectedness.
A few months ago, agj proposed the idea of releasing a few jam games based on the theme of masquerade under others' names. I released Michael's game as my own, Jonathan Whiting released mine (with art by agj) as his own, agj released Jonathan's as if it were his, and Michael released agj's under his name.
This plan was not necessarily meant to trick people. I was mostly curious about how it would feel to have a game released under another's name, and if any of us had a distinct enough style to make the ruse readily apparent. But mostly I was inspired by the theme and wanted to make a game and put it out there.
I expected to feel guilty when my game Face Time was released under another's name. It was my first visual novel, not written quite as well as I wanted, and intentionally featured a mostly unlikable protagonist with multiple neurological and psychological issues. As such, I was not entirely surprised when it received no comments on TIGForums, and mostly negative ones on the indiegames blog. It still felt terrible seeing nasty comments get addressed to Jonathan, who, unlike me, attached his real name to this endeavor.
What I didn't expect was how guilty I would feel when Michael's well-designed and clever and fun game spread from TIGForums to the Indiegames Blog to Rock Paper Shotgun to JayIsGames, to Brothersoft and on. I love his game. I am proud of his accomplishment. But I felt completely and utterly sick seeing all the praise for his game get addressed to me.
Which is kind of weird, you know? To most of those commenters, I might only exist to them as a four letter pseudonym on the internet, or maybe a collection of a few games or tweets, or even less than that for people giving feedback on sites which didn't even attribute the game directly to anyone.
Also adding to my guilt is the fact that I did nothing to promote his game beyond slapping it up on TIGSource. I responded to no forum posts. I emailed no sites about it. I haven't even been looking at the download statistics. I'm still not sure whether not engaging with the game was the right thing to do. It made me feel better in the short term, leaving the misattribution to inference and not strengthening it by acting as its creator in comments and blogs. But it also made me feel terrible in the long term knowing that I treated the release of another's game worse than if it were my own.
So, have I actually learned anything from this?
Ever since reading "Pierre Menard, Author of the Quixote" -- a short story by Jorge Luis Borges about how the novel Don Quixote would have a radically different meaning if it were written word-by-word by an unassuming 18th century French author than if it were written by the original 17th century Spanish author Cervantes -- I have firmly believed that authorship matters.
These games do reflect their individual authors' styles and interests. But at the end of the day, did it matter to the players of our games who claimed credit? I don't think so. These are all short projects which stand on their own merits.
I also don't think there's enough data to conclude anything from the fact that no one figured out that our four stated games were not our own. I think all that shows is that none of us are well-known for distinct styles, or even just well-known period, and the few developers that would be most familiar with our works were in on it from the beginning. Or it might be that players and developers implicitly understand that game designers are wholly capable of changing their styles.
For another perspective, you can read Michael's thoughts here at his blog. AGJ's viewpoint is also worth a look, as is Jonathan Whiting's reaction.
December 15, 2010
realnoyb AT gmail DOT com


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The Louisville zone of the Federal Reserve comprises southern Indiana and western Kentucky and a total population of approximately 3.4 million people, including the almost 1.3 million who live in the Louisville MSA.
The Little Rock zone of the Federal Reserve comprises the majority of Arkansas, except northeast Arkansas. The total population is approximately 2.5 million people, including the 710,000 who live in the Little Rock MSA.
Keep up with what's new and noteworthy at the St. Louis Fed. Sign up now to have this free monthly e-newsletter emailed to you.


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Jessica Simpson's Post-Baby Photo Shoot
Showing off a bit of her post-baby body, Jessica Simpson arrived at a photo shoot in L.A. today (October 1).
The Weight Watchers spokesperson displayed her gams in black short shorts and heels with a matching long-sleeved top.
Though she's currently on board with the pound shedding company, a source tells Radar Online that she once sought more drastic measures.
According to the insider, "After her daughter, Jessica felt there was no way she could lose the weight on her own as she has struggled so much in the past and her post partum weight seemed to be growing. So like a true Hollywood girl, she sought out a quick surgical fix - lap band surgery."
It is rumored that two different doctors rejected her plea for the surgery, but she soon sought to shed pounds naturally, enlisting the help of celebrity trainer Harley Pasternak.


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As I said yesterday, it isn't April 1st until next week. The Museum of Hoaxes is preparing for this annual clickathon by shifting most of its images onto another site. Otherwise they might well crash, as the mildly perplexed check up to see which of the morning's stories are true and which a wind up.
And it might be kind of hard to tell. This week has seem some credulity-stretching incidents, from the pregnant man (well, pre-op George Michael lookalike, but the law sez he's a he) to the supermarket thief who hypnotises checkout girls. Yesterday I brought you the German man who called the police to rid his flat of a mouse (they failed). Today, in another mammal-and-cops related incident, the Telegraph reports a court case from New Zealand. A 48 year old man was found guilty of wasting police time after he (take a deep breath) complained that he had been raped by a wombat, an incident which left him with an Australian accent. He made the whole thing up, of course: as everyone knows, wombats don't actually live in New Zealand.
Even big news stories this week have a large dash of the surreal. Thus we find France's oddly ludicrous president arriving in England just as a nude photo of his wife goes on sale in New York. Not a very good one, either, just going to prove that some women look better with their clothes on. The American election looks increasingly farcical, with Hillary Clinton's easily-debunked claims about having dodged Bosnian bullets just the latest inexplicable own goal. Meanwhile Britney Spears seems to be behaving like a normal human being for a change. Strange times indeed.
What are these weird stories doing, and why are they appearing now? I think it may be the press getting the silly season in early, while they still can. Odd believe-it-or-not news items typically dominate the summer months when no much else is going on, but that cannot be the case now. After all, Iraq, which has once again made it onto the radar screen of the west's restless consciousness, is in the midst of a renewed civil war. Afghanistan is an ongoing disaster. The financial gloom continues to deepen. We are looking, I suspect, at an approaching tsunami. Before the wave hits, water sucks from the beach, leaving behind the random detritus normally obscured by the shallows. There's just time to gawp before everything, and everyone, gets swept away.
Thursday, 27 March 2008
Mad World
As I said yesterday, it isn't April 1st until next week. The Museum of Hoaxes is preparing for this annual clickathon by shifting most of its images onto another site. Otherwise they might well crash, as the mildly perplexed check up to see which of the morning's stories are true and which a wind up.
Posted by Heresiarch at 5:48 pm
1 comment:
- silas said...
The tsunami image is a splendidly conceived one. Let's hope that after the storm, the calm returns and some green shoots of recovery are soon visible. Rather than the entire country just sinking under the water.
- 28 March 2008 at 09:28


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I wrote to lovely Sophia from the So Binique blog because I spotted her very white living room there and thought it would be nice to share corners of it on decor8 for some inspiration! I like to begin a new weekend feeling positive and motivated and nothing quite does it like seeing a beautiful home, eating a good meal, having social time with friends, a nature walk… and since we are sharing this virtual space together and I cannot cook for you — then I have chosen to show a beautiful room with lots of white to clear your mind and give you a fresh slate to work from for the weekend! :) Trust me, you are better off — my cooking skills leave much to be desired. :)
See any lovely ideas that you can use at home? Thank you Sophia for sharing your living room details with us today. :)
(images: So Binique)


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June 20, 2000
CONTACT: Ward Mullens
YPSILANTI - A collective bargaining agreement between Eastern Michigan University and the American Federation of State, County and Municipal Employees (AFSCME), Local 1666, was approved by the Board of Regents at its regular meeting June 20.
The new agreement between EMU and AFSCME Local 1666 covers maintenance, food service and custodial employees, and extends from May 10, 2000, to June 30, 2002.
The agreement includes a three percent across-the-board wage increase for employees at Grade 20 and below and a 3.5 percent increase for employees at grades 21 and above for the first year of the contract. Those wage increases are 3.5 percent and 4 percent, respectively, during the second year of the contract and 3.5 percent and 4.5 percent, respectively, during the final year of the agreement.
Among the negotiated changes in the collective bargaining agreement are: establishment of a 45-day time limit for filling vacancies; establishment of a new procedure for selecting employees for temporary upgrades; clarification of the basis by which a four-day, 40-hour work week can be made available; establishment of eligibility requirements for overtime, based on attendance; and modification of existing "student employee" language to include a clause that students shall not displace or replace a bargaining unit employee.
The new agreement is expected to increase the University's maintenance, food service and custodial employees' fiscal year 1999-2000 total compensation costs by approximately $199,685 and by $508,875 and $406,864 in the contract's second and third years, respectively.


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METAL/NONMETAL MINE FATALITY - On December 29, 2010, a 41 year- old laborer with 4 years of experience died at a dimension stone operation. The victim was replacing a hydraulic lift arm cylinder on a skid steer loader. The lift arms suddenly lowered, pinning him against the frame of the machine.
Establish safe work procedures and identify and remove hazards before beginning repair or maintenance tasks. Follow the equipment manufacturer's procedures for the work being performed to ensure that all hazards have been addressed. Train persons to recognize the hazards associated with performing repair or maintenance tasks. Prior to performing repair or maintenance tasks, turn the power off and block any raised component against accidentally lowering. Assign a sufficient number of persons to repair or maintenance tasks to ensure the tasks can be safely performed. Do not place yourself in a position that will expose you to hazards while performing repair or maintenance tasks. Monitor personnel routinely to determine that safe work procedures are followed.
|Submit your own suggestion for a remedy to prevent this type of accident in the future.
Please specify if you wish your submission to be anonymous or whether your name may be used. Please include the year of the fatality and the fatality number.
This is the 24th fatality reported in calendar year 2010 in the metal and nonmetal mining industries. As of this date in 2009, there were 16 fatalities reported in these industries. This is the 6th Falling Material fatality in 2010. There were 3 Falling Material fatalities in the same period in 2009.
The information provided in this notice is based on preliminary data ONLY and does not represent final determinations regarding the nature of the incident or conclusions regarding the cause of the fatality.
For more information:
MSHA's Fatal Accident Investigation Report


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Lisbon might soon have more difficulty accessing debt through the markets, precisely because Moody's is worried that it will. With rather circular reasoning, Moody's said it was placing Portugal's A1 rating on downgrade review because of "concerns about Portugal's ability to access the capital markets at a sustainable price". Yields will no doubt rise further on the news.
Moody's is also worried about the effect of bank support on the government's debt, as well as the impact of austerity measures. The rating looks perilous, then, since Moody's fears will rise whether Portugal cuts or spends. Read more


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|Draft Animal Cloning Risk Assessment
|FDA Comment Number :
|Submitter :
|Mrs. Sheri Bakunowksi
|Date & Time:
|01/04/2007 09:01:25
|Organization :
|Mrs. Sheri Bakunowksi
|Category :
|Individual Consumer
|Issue Areas/Comments
| I believe that the FDA's decision that cloned animals are "safe" to eat is very premature. More studies and simply more time needs to pass to see how these animals develop into old age, what happens to them during that time, and when the cloned animal dies, a careful look at the body should be taken and the body tissues tested extensively.
At the very least, meat NEEDS to be labeled for consumers whether it is FROM a cloned animal or not, or if the animal was FED with feed that had discards from cloned animals.
Right now, I have a very strong impression that this decision is biased and has "MONEY" behind it from the industry. Please demonstrate to me and others that this is not true by reversing this decision for now, until more information is known and more time has passed to allow for more knowledge to occur.
When the market gets to the point of selling cloned-animal meat, I am not going to purchase ANY meat and/or meat products for me and my family until the FDA and the industry proves to me that extensive safeguards will be taken.
Please do not damage the public's faith in the FDA and do the right thing.
Thank you -- Sheri Bakunowski


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Korg TM-50 Pearl White
Tuner and Metronome
- Voice and metronome function can be used simultaneously
- Fast response LCD needle meter
- High detection range: C1 - C8
- Internal speaker for issuing reference notes
- Sound Back function generates reference tone that's closest to the input sound
- Calibration supports a range of concert pitches
- Marks indicate pure major and minor third intervals
- Pace set in the range 30 ~ 252 beats / minute
- 15 Rhythm variations
- Tempo settings with two types of tempo step patterns plus a tap tempo function
- Large backlit LCD brightness adjustable in two steps
- Memory backup and power saving function
- Colour: White
- Includes 2x AAA Batteries
Further information
|Integrated Microphone
|Integrated Metronome
|PSU Connector
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