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Winkler carries no-hitter into seventh
Rockies prospect notches Minor League-leading ninth win
By Josh Jackson / Special to MLB.com | June 15, 2013 10:25 PM ET
Between innings on Saturday night, Dan Winkler found himself a lonely man in the Modesto Nuts dugout.
"I was in no-man's land," he said. "I was like, 'Why won't people talk to me?' I know they didn't want to jinx me, but ... "
The Rockies prospect carried a no-hitter into his final frame before giving up a double over seven scoreless innings as Class A Advanced Modesto beat Bakersfield, 6-4.
"Overall, it was a mediocre start," said Winkler (9-2), who struck out eight batters, hit one and walked another. "I didn't feel like I had my good stuff tonight. My location wasn't good and I just felt a little off. That's baseball. You can have not your best stuff and things still work out for you. Guys made good plays behind me and hard-hit balls went right at guys. I had a little luck, but I'll say, too, that I had good moments with my slider."
After the Rockies took him in the 20th round of the 2011 Draft, Winkler went 11-10 with a 4.46 ERA for Class A Asheville in his first full season. He's been a different kind of pitcher this year, leading the California League in wins, ERA (2.15) and strikeouts (98).
"People have been telling me that," Winkler said. "It's just stats; I try not to focus too much on stats. It's not going to help me in the long run if I'm worried about that. I'm worried about getting wins for this team and putting together a good run in the second half so we can play in the postseason."
On Saturday, he recorded six of the first 11 outs via strikeouts.
"I just made some pitches when I needed to," the 23-year-old right-hander said. "[Nuts catcher Will] Swanner was putting down the right fingers. I was missing some locations, but they happened to be in good spots."
Winkler hit Juan Silverio in the third and walked Reds No. 16 prospect Kyle Waldrop with two outs in the fifth.
"I tried to go with a first-pitch changeup down and I missed. Then I threw back-to-back sinkers and I got underneath them," Winkler said. "Then on 3-0, I got away from my approach. Whatever. It's going to happen sometimes in a start."
Then he retired five straight batters, starting with a strikeout of Silverio.
"I felt better as the game went on. I started making pitches and was feeling confident," he said. "I really didn't think about the no-hitter too much. I was just trying to get team a win because we'd lost four in a row."
With one out in the seventh, Juan Silva smacked a line drive over the head of center fielder Tyler Massey for a double.
"I was a little disappointed," admitted Winkler, "not so much that I gave up the hit, just in the pitch. It was a 1-1 changeup and I hung it. I wanted it to drop out of the zone a little, but it stayed up."
With Silva on second, Winkler got a fly ball and ended his night with another strikeout.
"Of course," he wanted to keep going, he said, "but I understand pitching limits. If I'd had a no-hitter, I would've gotten 10 more pitches, I guess."
Swanner, the Rockies' No. 7 prospect, drove in two runs and Ryan Casteel was 3-for-4 with a double and three RBIs.
For Winkler, whose name hadn't shown up on many top prospect lists entering the season, the first half he's put together has been somewhat vindicating.
"I came into pro ball with a chip on my shoulder because I felt like I was better than a 20th-rounder. The Rockies gave me an opportunity and I want to prove to them and everybody else I have the stuff to compete," he said. "It means a lot to be able to do that. But as far as the attention goes, I'm still no better than anybody else, just because I'm pitching better."
Josh Jackson is a contributor to MLB.com. This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.View More


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2,526 reviews
- Chicago, IL
- 4 Year
- AcademicsA-
- ValueA-
- DiversityA
- CampusB+
- AthleticsB
- Party SceneB
- ProfessorsB+
- LocationA
- DormsB
- Campus FoodB
- Student LifeB+
- SafetyB-
Loyola University Chicago is ...
Private not-for-profit, Catholic
Athletic Division
NCAA Division I-AAA
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Missouri Valley Conference
Loyola University Chicago Rankings
Niche rankings are based on rigorous analysis of key statistics from the U.S. Department of Education and millions of reviews.
Acceptance Rate
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High School GPA
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Test Scores and GPA for Loyola University Chicago
Net Price
$31,069/ year
Average cost after financial aid for students receiving grant or scholarship aid, as reported by the college.
Based on faculty accomplishments, salary, student reviews, and additional factors.
Student Faculty Ratio
Evening Degree Programs
- 82%
- of students agree that professors put a lot of effort into teaching their classes.168 responses
- 48%
- of students agree that it is easy to get the classes they want.172 responses
- 48%
- of students agree that the workload is easy to manage.172 responses
Most Popular Majors
Full-Time Enrollment
Undergrads Over 25
Pell Grant
Varsity Athletes
What one word or phrase best describes the typical student at this school?
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Campus Life
Freshmen Live On-Campus
- 49%
- of students say that Greek life is average, and no one will treat you differently if you don't join.204 responses
- 61%
- of students say varsity sporting events are attended, but not a huge part of campus life.234 responses
What one word or phrase best describes your school?
Based on 118 responsesReport
After Loyola University Chicago
Median Earnings 6 Years After Graduation
$50,600/ year
Graduation Rate
Employed 2 Years After Graduation
- 80%
- of students feel confident they will find a job in their field after graduation.123 responses
Colleges like Loyola University Chicago
- ADePaul University
- 4 Year
- Chicago, IL
- 3,183 reviews
- B-Saint Xavier University
- 4 Year
- Chicago, IL
- 802 reviews
- A-University of Illinois at Chicago
- 4 Year
- Chicago, IL
- 2,737 reviews
- B+Dominican University
- 4 Year
- River Forest, IL
- 601 reviews
Loyola University Chicago Reviews
2,526 reviews
Review Loyola University Chicago
I love the rich student diversity on campus. I am constantly in awe of the students that I am surrounded by in my classes everyday as they all come from different backgrounds and contribute to the diversity on campus. Loyola's campus is also gorgeous! Taking a stroll around campus during the fall or summer time immediately puts me in a better mood. One thing that disappoints me about LUC, however, is the financial aid office because they are not accessible or helpful to students.
I'm currently a senior at LUC and I have definitely enjoyed my four years here. There is a lot to do because you're so close to the city. I will say that there are not many parties (mostly just run by fraternities), so turning 21 and going to the bars made me enjoy the city a bit more. The campus is beautiful, despite the area around it being not so great. The classes aren't too hard, but they are challenging enough where you don't feel like it's too easy. I enjoyed my time here, even though my wallet has been emptied!
I like the campus itself. It's truly beautiful; it faces the lake and it is just a god-sent to wake up to every morning. The cool thing about Loyola is that there's always something to do. Whether it's events in your residence hall, events on campus, or just studying for your major, I feel like it is pretty hard to be bored on this campus. I'm giving it three stars because I personally find it to be challenging here, but only because my major (which is Nursing!) is pretty difficult! It is definitely more oriented around academics and less around the party scene. If you want to go to a place where you will actually get stuff done and not just drink your problems away at the bar, then here's the place. Other than that, the campus gives off a fun vibe, but people here know how to buckle down and do well.

subset: commoncrawl


text:
I am a bit frustrated because I cannot find any dofollow forums and blogs, I searched google and I found lists but whenever I check those sites they are nofollow. Is there any software out there that someone can recommend that can scan to find dofollow forums and blogs within certain topics? Not trying to spam but would like to post in places were I can get backlinks from as well.
I checked my competitors their backlinks come from non-relevant websites that are basically part of farms.
I know that you don't have intention to spam, but there are some blogs out there that have the dofollow attribute but are grouped along with those comments that don't contribute anything to the post, i.e. spam. You wouldn't want to be grouped with with those links. Anyway, to answer your question, there's a site that can help you find blogs with specific comment engines. Search for "dropmylink" on Google, and you'll see it on the top results. It helps you add the footprints that you would need in searching for different types of blogs.
Many forums these days aren't do follow because it encourages spam because people just want the links, and many of those forums are highly ranked. The only one I know of is digitalpoint but for that you have to be a premium member.
Well most of the lists are not fresh thats why its not easy to find them, there are some people who finds do follow links and sell them as a list monthly...
You are right. It is really hard to find websites with dofollow links. But there are many forums with this facility. Digitalpoint forums, zymic forums etc.
For do follow links focus on Web 2.0 sites and article submissions. You will get high quality back links from Web 2.0 sites and article directories. There are many Web 2.0 and article directories from where you can get huge number of back links for your website.
I wouldn't avoid nofollow blogs and forums altogether if I were you. I am assuming Google adds some value to them. I have many nofollow links from blogs and forums showing up in my Google webmasters tools as links to my site. I didn't post with the the intentions of getting links, but they are their nonetheless.
I assume with everyone now using nofollow, Google will eventually change things up.
Awesome thanks for the website suggestion it has been very helpful. I just want to create some additional backlinks to the website. I been submitting my website to general and niche web directories. Just difficult finding any sites that are dofollow.
Understandable about the issue with spam. I like how sitepoint works with it, where you have to be a certain member in order to get the "nofollow" attribute removed from your links. I don't avoid nofollow I just can't make it all nofollow.
I don't understand this. Perhaps you could explain what you mean by a Web 2.0 site, and why you think this kind of site would give high quality links that are not nofollow.
Unless I'm missing something here, all links on the SitePoint forums are nofollow.
Unless I'm missing something here, all links on the SitePoint forums are nofollow.
I have been searching for such tool in the past and I found soething which can hopefully help you. However, bear in ming normal/human internet behaviours and do not spam forums and blogs as othet people have already said.http://www.dofollowchecker.com
You can do article writing and submission. There are lots of do follow article directories. You can also do blog posting and build links from blogs. These links are also do follow. If you want to find do follow blogs then you can use a software especially for do follow blog finding. You can download this software from fastblogfinder.com
I agree with the poster above who said do not ignore nofollow links. It would be unnatural for a site to only have dofollow especially since most are not going nofollow do to the amount of spam it attracts.
I have do follow forums & blog lists. If admin permits me i would able to share them.
Pm me the list and I will see if it is worth it to add them to our resources list. Still, people need to understand that posting for the sake of posting helps...0 no matter if the forum/blog is do-follow or not
You should stop building links via forums and blog comments. They mean close to nothing. Just generate good content - it will attract traffic on its own.
Why would that be unnatural? All it means is that the website owner hasn't been spamming forums and blogs left, right and centre. I'm pretty certain that most (if not all) of the links to some of my websites are "follow"able links, precisely because they are all organic, natural and relevant. Unless you've got any evidence to the contrary, I would be staggered if Google penalises sites that don't have nofollow links.
you can get only best results via Mix link building services. backlinks only from one place will never help you in SEOtry to be focus on quality not on quantity


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The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of American City Business Journals.
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Lacrosse news straight to your inbox.
Tuesday August 6th, 2013 1:12am
AMHERST, Mass. - Sophomore attack Sam Rush hit the game-winning goal just before time expired in overtime to give the No. 17 UMass women's lacrosse team a 9-8 win over Albany on Friday afternoon at McGuirk Stadium. The Minutewomen held for the last shot in the overtime period but could not get a clean look on cage. As time ran down under 5 seconds, Katie Ferris rolled the crease before having to toss a pass in front of the crease where Rush was able to one-time the game-winner just before the horn sounded to end the period.
The result marked the second straight year the two teams have needed overtime to settle the score and the third time in as many years the game was decided by two-or-fewer goals. Last season, Nina Sarcona hit the game-winning goal in overtime at Albany as UMass prevailed 12-11. In 2011, it was Albany who defeated UMass in regulation at Garber Field 10-8 with both teams undefeated and ranked in the top-20.
UMass improves to 5-2 overall with the win, while the Great Danes fall to 2-2 overall.
Rush finished the game with three goals, while Ferris added three more and had her assist on the game-winner. Cori Murray had three assists, while Lauren Terracciano and Katie Boden each finished with a goal and an assist each. Rachel Vallarelli earned the win making three saves in 66 minutes of work.
Maureen Keggins, Rachel Bowles and Rachael Burek each notched two goals to lead the Albany offense. Nicole Eamer had two assists on the day, while Keggins also added a helper for a team high three points. Goalie Anna Berman made eight saves in the loss.
The Great Danes held a 5-4 lead at halftime after closing the opening stanza on a three goal run.
At the start of the second half, Jess Antelmi scored to put Albany up 6-4 just over six minutes into the period.
UMass responded with a three goal run of its own sparked by Boden's assist to tie the game at 6-6 followed by her goal 15 seconds later giving the Minutewomen the lead with 20:41 to go.
Both teams traded goals over the next eight minutes with Bowles second of the day tying the game 8-8 with 12:41 left in regulation.
UMass had two chances to win in the final five minutes, but Berman made a spectacular save on a point-blank shot by Ferris and then Ferris' second attempt with 21 seconds to go went wide right. A turnover with three seconds left allowed Albany to run out the clock to force overtime.
In the first three-minute session of the overtime period, Ferris had three more shot attempts, but two were wide and the third was blocked.
Albany gained possession of the ball with time expiring and managed to clear the ball into its offensive zone, but could not set up a scoring opportunity before the teams had to switch sides and re-draw to start the second half of the overtime period.
After the Great Danes won the draw to start the second half of overtime, Tanner Guarino collected a fumbled Albany pass allowing UMass to call a timeout to set up its offense with 1:40 left in the game.
The Minutewomen outshot Albany 27-to-12 for the game, including 4-to-0 in overtime and forced 22 turnovers while committing just 13. Albany held the advantage in the draw circle winning 13-of-20 on the day.
UMass will return to action next Wednesday, March 13 against Vermont at McGuirk Stadium. The opening draw is set for 4 PM and admission is free to all.


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Lacrosse news straight to your inbox.
Monday July 23rd, 2012 5:03pm
Box score
BUFFALO, NY – Detroit started the day with four goals in the first five minutes and ended with a season high 17 as the Titans stormed past Canisius, 17-12, in the MAAC opener for both schools on Saturday afternoon at the Demske-Sports Complex.
Detroit evened its record to 4-4 on the year, while the Golden Griffins fell to 1-2. The 17 goals by Detroit were the second-most in Titan history following the 19 they scored against Mercer last season in a 19-3 win.
"I think they are a very similar team to us, but this game was all about momentum," said head coach Matt Holtz. "We had it early and then they had it and luckily, we were able to get it back and get the win."
Sophomore Joel Matthews (St. Catharines, ON/Holy Cross) was the star offensively with a career-high seven goals – tying a school record - for his 10th career hat trick. It was the third-straight game that Matthews has recorded a hat trick and his sixth career game with four or more goals. He also added an assist for a school record eight points, and he now has 15 points in the last two games on 10 goals and five helpers.
Sophomore Shayne Adams (St. Catharines, ON/Denis Morris) tallied three goals for his ninth career hat trick, while senior Tim Lehto (Farmington, MI/North Farmington) and sophomore Alex Maini (Lynbrook, NY/Lynbrook) each added two goals apiece.
"We feel as though Joel and Shayne are as good a combination in the MAAC as anyone has," said Holtz. "They had 10 goals, but we got a lot of good play out of other guys, especially our midfielders. They played great for us."
The Titans – who had leads of four and three in the game –found themselves down by one, 11-10, with just under three minutes left in the third.
That is when the red, white and blue took complete control with six-straight goals, scoring twice in the last 46 seconds to regain the lead heading into the fourth. Lehto notched his second to tie it and then Adams took a pass from Matthews for the go-ahead marker with nine ticks left.
That momentum carried right over into the fourth as Detroit fired in four goals in the first two minutes of play. A caused turnover by junior Jordan Houtby (St. Catharines, ON/Holy Cross) started the fourth quarter surge and Maini was the benefactor connecting on his second goal with 14:01 remaining. After that, junior Brandon Davenport (Grosse Pointe Woods, MI/GP North) won the face-off and quickly got the ball to Adams who put it away just six seconds later.
After a Canisius timeout, another Davenport face-off win led to senior Scott Harris' (Saline, MI/Saline) lone tally 30 seconds later and just 14 seconds after that, another Davenport victory led to Matthews scoring and the Titans had their largest lead, 16-11, with 13:10 left in the game.
"Davenport was definitely one of the stars of this game. We were struggling a bit with face-offs during their run, but he won the key crucial ones that allowed us to not only get the lead back, but the momentum too and that went a long way in us winning this game," added Holtz.
Matthews would net his career high midway through the period to give the Titans a 17-12 lead, which turned out to be the final victory score.
Davenport won 14-of-26 face-offs in the game, a season high for wins and the 13th game of his career with double-digit face-off victories. He also picked up four ground balls.
Houtby ended the game with two caused turnovers and a team-high five ground balls, while junior Jamie Hebden (Farmington Hills, MI/Brother Rice) posted two caused turnovers and four GB's.
Lehto, senior Jason McDonald (Bayport, NY/Bayport-Blue Point) and junior John Dwyer (Novi, MI/Detroit Catholic Central) all had two caused turnovers apiece with McDonald and Dwyer coming up with three ground balls. McDonald also added his third goal of the year.
Junior A.J. Levell (Columbus, OH/Dublin Scioto) made 10 saves to earn the win.
"I thought A.J. played well and made the saves we needed him to make," said Holtz. "Overall, our defense played well. We were a little shorthanded with an injury and we were moving people in and out, but they did a good job."
The Titans began the day with four goals on its opening five shots. Sophomore Scott Drummond (Birmingham, MI/Seaholm) started the offensive barrage with a goal just a little more than a minute into the game. Matthews followed at the 12:15 mark and Lehto made it 3-0 just a minute later. Just 40 seconds after that, Matthews had his second.
That lead was short lived as Canisius rallied with four-straight goals to end the first period and would take a 5-4 lead early in the second.
UDM would knot the game on Adams' first goal and Matthews would put the Titans back ahead, but the Golden Griffins tied it once again at 6-all with 9:33 left in the second. Detroit would never trail the rest of the half taking an 8-7 lead at the intermission.
Matthews then gave the Titans a 10-7 lead at the 9:51 mark with back-to-back goals, but once again Canisius would go on a spurt scoring four-straight to take an 11-10 lead with 2:52 left in the third quarter.
On the day, Detroit had 17 caused turnovers, while Canisius had 30 total turnovers. UDM also held a slim 33-31 edge in shots
After eight games on the season, the Titans will finally return home to play in the Motor City as UDM welcomes Marist into Titan Field next Saturday. Game time is set for Noon.
Game Notes:
Prior to today's game, the teams had split its first two games with each posting a one-goal win on its home field…Matthews had seven goals on just eight shots…Adams had seven goals against Mercer last year…The most goals UDM had scored in MAAC play was 14 in a 14-7 triumph over Wagner in 2010…The 17 caused turnovers were the second highest on the season following the 20 UDM recorded at Mercer…The Titans had held opponents off the board on 13-straight penalties until Canisius netted one with the man advantage in the first…Overall, after allowing 12 man-up goals in the first four games, the Titans have allowed just one in the last four killing off 15-of-16 penalties…Detroit is now 6-2 in its last eight regular season conference games…


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This is the money clip that has an integrated bottle opener on one end. With a tight spring mechanism and sturdy hinge, it maintains a firm grip on up to 20 bills at once and will not slip or loosen, even when maneuvered around a bottle cap. The clip also fits around the accompanying black crocodile print wallet, which contains slots for six credit cards and a generous center compartment for holding receipts, photos, and business cards. Easily slipped into a front pocket or tucked inside a jacket, the slim bundle provides unobtrusive organization while ensuring that a host or party guest's crucial gadget is always handy. Made from stainless steel with a gunmetal zinc alloy finish. Presented in a leather gift box. 4" L x 2 3/4" W x 3/4" D. (4 oz.)
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Bottle Opener Money Clip
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Mediterranean Coast Filled Candle
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Custom blended from the finest aromatics, our collection of scents draws inspiration from the natural world and objects found in destinations abroad. Beautifully packaged, the pieces in this collection make elegant hostess or housewarming gifts.
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|Increase credit hours in Child & Adolescent Health Nursing I
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|Fall 2000
|Brief Summary of Proposal
|Credit hours of the courses in the Child and Adolescent track are being increased by one credit each to reflect the clinical and didactic hours contained in the courses. This will increase the track from 23 credits to 28 credits.
|Type of Proposal
|Course changes only
|Graduate School Endorsement Status
|Graduate School Endorsement Updated
|December 13, 1999 by GS asst to dean Dolli Markovich
|Institutional Research Status
|IR Status Updated
|December 16, 1999 by IR Dolores Bezilla
|Library Status
|Not required
|Library Status Updated
|November 11, 1999 by UL Nancy Hayes
|Distance Learning Review Committee Status
|Not required
|DLRC Status Updated
|Resource Requirements
|No additional resources
|Resource Requirements Updated
CPS Menu


text:
On the Shelf
These Big Eyes Are Lies, and Other NewsBy Dan Piepenbring
- Putin has signed a law banning foul language in plays and movies; any books with cuss words will come in sealed packages, with warnings. Which words qualify as uncouth? A panel of "independent experts" is soon to convene in pursuit of that very fucking question.
- Meanwhile, in America and the UK, an unexpurgated edition of F. Scott Fitzgerald's Taps at Reveille—its expletives intact; its sex, drugs, and anti-Semitic slurs restored—will arrive next month.
- Long before the heyday of Lisa Frank, there was the pop artist Walter Keane, who became something of a household name in the sixties: his work depicted sad children with enormous, farcically melancholy eyes. But his wife Margaret deserved all the credit: "The man wasn't a painter at all. Margaret was the creator of all the Big Eye art. Walter basked in the glory, partied with the celebrities, and reaped the rewards. As she would later relate, the tearful, doe-eyed children she painted had nothing to do with Walter's supposed belief in children redeeming the world. The weeping waifs reflected her own sorrow."
- Revising the myth of Phineas Gage, who survived, in the late nineteenth century, an accident in which an iron rod went straight through his head, and who has been fodder for Psych 101 students ever since. "Recent historical work, however, suggests that much of the canonical Gage story is hogwash, a mélange of scientific prejudice, artistic license, and outright fabrication. In truth each generation seems to remake Gage in its own image, and we know very few hard facts about his post-accident life and behavior."
- "How do you design cities and civic spaces in ways that account for people's varied reactions to sound itself? Where does 'sound' end, and 'noise' begin?"


text:
Experts Expound
Will California's 2016 presidential primary be meaningless — again?
Experts Expound: "Too little, too late? Will California's 2016 presidential primary be meaningless in the process of picking a president?"
Experts Expound: "Too little, too late? Will California's 2016 presidential primary be meaningless in the process of picking a president?"
Editor: Democrat Steve Glazer will be sworn in today to the state Senate from the 7th District. Since Steve's election victory by over 11,500 votes on May 19, I have read comments in news articles that if this was a closed Democratic pimary, Steve would not have won or if it was a regular special, Steve would not have won, and a lot of ifs.
Editor: The article you reprinted from an online blogger about administrative staff growth at the University of California ("UC administrative staff tripled in two decades," Capitol Weekly, April 23) lacks critical context and as such, makes inaccurate comparisons.
The increase in UC's administrator positions is largely due to significant growth in the university's health enterprise,
Dear Big Daddy,
Why don't more legislators become governors? They are all ambitious politicians, aren't they?
–Curious in Cucamonga
In recent years many of us have spent far more time than necessary at various public meetings awaiting our three minutes to speak during "Public Comment," an item often placed dead last on the agenda. By that time, most of the attendees have long departed.
ProPublica took a variety of half-truths to create a totally false impression about the good works of the leading pro-troop, grassroots charity in America.
"The LAO says the state is flush with cash and multibillion-dollar reserves loom in coming years. How should we spend the money?"
Dear Big Daddy,
You're a Democrat and you're old, so what's your take on The Return of Jerry Brown?
–Intrigued in Indio
Dear Intrigued,
I thought that after hanging around the Capitol for so many years, there was nothing left that could amaze me. But he's managed to do it.
He was down and
Dear Editor: I am writing to put to rest the distorted untruths being advanced by the opponents of SB 131 gratis norsk. My bill seeks to give the adult survivors of childhood molestation their day in court against the organizations that enabled their molesters – nothing more, nothing less. The facts
Capitol Weekly, which covers state politics and government, is owned and operated by Open California, a public benefit corporation.


text:
Kinda that "I'll show you mine if you show me yours" taken to a different place.....LOL.
When I first thought of a name I was very, very sad. Thus...the name "teadrop" here.
I'm still very, very sad....but "clay"...and "time passing" has brought on a new perspective and a new feeling of honor towards my son's memory. I'm not blowing glass like he did....but we ARE making glass just the same....
He was and will always be "Mtn-BURN".....and he marked his glasswork as such.
In his honor...I have also chosen the moniker "Mountain Burn". It is my Facebook name (stop by!) and now....the name of my new pottery (klunkery!) business.... "Mountain Burn Pottery"
80 peices stamped so far. If you see this logo out there....it's >>my<< crap yer lookin at! I also had a stamp with just the mountains and "BURN" made that is smaller....
Gonna do some T-Shirts as well.... cus with a slogan like "Have you BURNED today?" or "Let's BURN one".....I think they could easily be popular items around here...LOL.
No matter what....this should be loads of fun. Not only is it great therapy for the head....I also feel i am honoring my son and his love of glass and glassblowing.
So if yer out there....look for my ceramic work or look for my tattooed ankle...'cus both are marked with the moniker "Mtn-BURN"


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Previous Episode | Next Episode
The Secret Of Quan ChiThe Secret Of Quan Chi (1996) - Mortal Kombat: Defenders of the Realm Cartoon Episode Guide by Dave Koch
This page has been viewed 16 times this month, and 443 times total.
- Mortal Kombat: Defenders of the Realm Cartoon Episode GuideEpisode GuideTelevisionSeriesCartoon
- Film Roman, Threshold Entertainment
- First Aired on November 09, 1996.
- Originally Aired on USA Network (USA).
- Running Time: 30 minutes.
- Color
Cartoon Summary:
The series chronicles the adventures of the Chosen Warriors assembled to protect the Earth from the evil emperor Shao Kahn.
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text:
LISTEN: Dimitri Vegas & Like Mike's Tomorrowland anthem 'Chattahoochee'
Listen to Dimitri Vegas & Like Mike on iHeartRadio
Dimitri Vegas & Like Mike are back with another electrifying Tomorrowland anthem. Recently world premiered on BBC Radio, and premiered in the U.S. on Evolution Radio, this is a sure fire dance floor destroyer.
Named "Chattahoochee," which is where very first TomorrowWorld will be held, the track is massive - dare we say mammoth? - and packs a punch with a dynamic build leading to an epic drop, and pounding beat.
Check out the comic book version of the guys running from an angry tribe, and a giant T-Rex in their "Chattahoochee" preview video:
Check out Pete Tong with the world premiere of the track:
The guys also did a powerhouse guest mix, and if this is what we can expect from them at Tomorrowland - we can't wait for their set! Check it out below:


text:
Meningitis results from the inflammation of the meninges (the thin membranes surrounding the brain and spinal cord). It is usually caused by a viral or bacterial infection. Most cases of meningitis are viral, but it can be hard to tell the difference without invasive testing. It is extremely important to determine the type of infection (and bacteria), because bacterial meningitis tends to be much more serious and requires emergency treatment. Viral meningitis usually clears up on its own and does not cause any permanent harm. Bacterial meningitis can cause brain damage, learning disabilities, hearing loss, or even death without treatment for the specific type of bacteria. Rarely, meningitis can be caused by fungal infections (cryptococcus).
Early symptoms of meningitis can easily be mistaken for the flu.
In newborns, signs and symptoms include the following:
In children and young adults, signs and symptoms include the following:
Older adults may have no signs or symptoms other than altered mental state and lethargy. Often they have no fever.
Bacterial meningitis is not as common as viral meningitis, but it is more serious. Several types of bacteria can cause meningitis. Knowing the right type is crucial for proper treatment:
Viral meningitis can be caused by several types of viruses, but the most common are enteroviruses (which cause stomach flu and multiply in the intestinal tract). Other viruses that cause meningitis include:
These conditions and characteristics increase the risk for bacterial meningitis:
If you or your child has symptoms of meningitis, seek emergency treatment. Early diagnosis is the key to treating meningitis successfully. Doctors will ask for a detailed medical history and may order a lumbar puncture (spinal tap). In this test, doctors remove cerebrospinal fluid from the spine through a needle so that the fluid can be tested for infection and to identify the kind of bacteria responsible. If your doctor suspects bacterial meningitis, your doctor may start you on antibiotics before the test results are available.
Children should be vaccinated against H. influenzae and mumps. People over 65 and those whose immune systems are compromised should receive a pneumococcal vaccine (PPV). A meningococcal vaccine may be given to control epidemics in dormitories, for example. Because meningitis is usually contagious, practicing good hygiene, such as washing your hands frequently -- and teaching children to do the same -- can reduce your risk of catching the disease.
The length and type of treatment varies depending on the kind of meningitis being treated, ranging from 1 - 3 weeks. The treatment for most cases of viral meningitis is aimed at reducing symptoms of fever and aches. Sometimes, doctors prescribe acyclovir, an antiviral drug. If bacterial meningitis is suspected, antibiotics must be started immediately, even before results from lab tests have been returned. Some of the medications used for bacterial meningitis are:
Meningitis must be treated with conventional medical therapies, especially antibiotics. Complementary and alternative therapies should be used only with conventional treatment, not in place of it, and only under the guidance of a qualified health professional. Some supplements and herbs may help strengthen the immune system, and homeopathic remedies may help relieve symptoms that accompany meningitis. Tell all your providers about any CAM therapies you may be using.
Several nutrients can help strengthen the immune system, possibly helping to prevent meningitis or to build up the immune system after meningitis has been treated, though scientific studies have not examined these nutrients specifically for meningitis. Talk to your doctor before taking any supplements, and never treat a child without talking to your doctor first.
You may address nutritional deficiencies with the following supplements:
Herbs are generally available as standardized, dried extracts (pills, capsules, or tablets), teas, or tinctures/liquid extracts (alcohol extraction, unless otherwise noted). Mix liquid extracts with favorite beverage. Dose for teas is 1 - 2 heaping teaspoonfuls/cup water steeped for 10 - 15 minutes (roots need longer). Some herbs may help support your immune system, although there is no evidence they can prevent or treat meningitis. Meningitis is a medical emergency and should never be treated with herbs alone.
Although few studies have examined the effectiveness of specific homeopathic therapies, professional homeopaths may consider the following remedies to help alleviate symptoms of meningitis, in addition to standard medical care. Before prescribing a remedy, homeopaths take into account a person's constitutional type -- your physical, emotional, and psychological makeup. An experienced homeopath assesses all of these factors when determining the most appropriate remedy for each individual.
These treatments must not be used for meningitis without direction and supervision by an appropriately trained and certified homeopathic doctor.
About 25 - 30% of people with bacterial meningitis die from it. Among pediatric patients who survive bacterial meningitis, 20 - 50% have brain damage, hearing problems, or developmental difficulties. Most people who get viral meningitis recover completely without any problems. However, some people will experience headaches, weakness, and fatigue for 2 - 3 weeks after symptoms begin.
Complications of meningitis may include hearing loss, seizures, cerebral edema (brain swelling), weakness on one side of the body, speech problems, visual impairment or blindness, difficulty coordinating movements, trouble breathing, respiratory arrest, and recurring meningitis. Children who have meningitis may experience cognitive impairment and developmental delay.
For the first 1 - 2 days, patients should be monitored in the intensive care unit to be sure the medication is working, to watch for any seizures, and to watch for breathing difficulties. If signs and symptoms do not improve after 1 - 2 days, health care providers should check the cerebrospinal fluid again.
Pregnant women often carry L. monocytogenes and S. agalactiae without having symptoms and may pass these infections to their children during birth. Pregnant women should not take rifampin to prevent meningitis because it is not clear whether this drug may harm the fetus.
Bamburger D. Diagnosis, Initial Management, and Prevention of Meningitis. American Family Physician. 2010; 82(12).
Bhat KPL, Kosmeder JW 2nd, Pezzuto JM. Biological effects of resveratrol. Antioxid Redox Signal. 2001;3(6):1041-64.
Bope and Kellerman. Conn's Current Therapy 2012, 1st ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.
Ferri. Ferri's Clinical Advisor 2013, 1st ed. Philadelphia, PA: Mosby, An Imprint of Elsevier: 2012.
Grandgirard D, Leib S. Meningitis in Neonates: Bench to Bedside. Clinics in Perinatology. 2010; 37(3).
Hernandez M, Mejia GI, Trujillo H, Robledo J. Effectiveness of the antibiotics chloramphenicol and rifampin in the treatment of Streptococcus pneumoniae-induced meningitis and systemic infections. Biomedica. 2003 Dec;23(4):456-61.
Jimenez Caballero PE, Munoz Escudero F, Murcia Carretoero S, Verdu Perez A. Descriptive analysis of viral meningitis in a general hsopital: differences in the characteristics between children and adults. Neurologia. 2011; 26(8):468-73.
Kim BN, Peleg A, Lodise T, Lipman J, Li Jian, Nation R, Paterson D. Management of meningitis due to antibiotic-resistant Acinetobacter species. The Lancet Infectious Diseases. 2009;9(4).
Kwang S. Acute bacterial meningitis in infants and children. The Lancet Infectious Diseases. 2010;10(1).
Lalwani AK, Cohen NL. Longitudinal risk of meningitis after cochlear implantation associated with the use of the positioner. Otol Neurotol. 2011; 32(7):1082-5.
Long. Principles and Practice of Pediatric Infectious Diseases, 4th ed. St. Louis, MO: Saunders; 2012.
Mandell: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed. Philadelphia, PA; Churchill Livingstone. 2009.
Srinivas D, Veena Kumari HB, Somanna S, Bhagavatula I, Anandappa CB. The incidence of postoperative meningitis in neurosurgery: an institiutional experience. Neurol India. 2011; 59(2):195-8.
Swartz MN. Bacterial meningitis. In: Cecil Textbook of Internal Medicine. Vol. 2. 21st ed. Philadelphia, Pa: W.B. Saunders Company; 2000:1645-1654.
Thigpen MC, Whitney CG, Messonnier NE, et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011; 364(21):2016-25.
Waghdhare S, Kalantri A, Joshi R, Kalantri S. Accuracy of physical signs for detecting meningitis: a hospital-based diagnostic accuracy study. Clin Neurol Neurosurg. 2010; 112(9):752-7.
Williams JE. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev. 2001;6(6):567-79.


text:
illadel mop jon
mini mop wit teal smash. mmmm
illadel mop jon
mini mop wit teal smash. mmmm
PM me if your in the 570
Bombing: Kiwi mops filled with GJ, 4 white 4 black Illegal Squad cans, Pink Dots and German Outline 1's.
Piecing: Illegal Squad Cans, German Outlines, Orange dots, tape and a stool (y)
Everyday venturing: Pilot Jumbos, Slaps and sometimes a Stampendous mop.
Gold dots are way too thick for me.
free paint is my weapon haha
Streakers, black Pilot, shoe polish mops (love the silver ink), drill bits, outline and fatcaps, ect...
mtn matte black witha pink dot
bingo dabbers with my own brew
50%garvey 25%febings 25%secret
"You are a fat toy who's moms a whore." -LACAN
Black can
Yellow can
Black mop
Some type of deco
Markwell, they're smooth
Pentel White
OTR Hard TO Buff. Looks nice
dubstep, cigarettes, tremclad, montana, and split streaks.
backpack full of paint and a can of bearspray for me anyone see you you hose em down and deek it always works like a charm.
word is bond.
I bring my llama, And a bag of midgets and sometimes some music so we can paint and have sexy parties.
snitches get stiches like bitches dumped in ditches and burned to death like witches. RDUB. BLATLBAT TYG
mini molotow marker w home brew
woodcraft white(i know its acrylic but its nice)
some slaps and a mop w black
white out pen THINNED
fatty backpack of paint and a uni paint pen, and a piece of a coffie mug, the ciramics cut the fuck outa glass.
i still have to say no matter what marker is out on the market today if you ever have a chane to get your hands on the old school mini wide i highly recommend it. it is still by far the best marker ever made.
found one on ebay if i had the cash i would get it but iam broke as hell
that's the link i thank
fuck yah iam fuckin back
lol, keep that shit UNJUICED if anyone uys that.
Shit i got 2 for trade one unused mint condition and one that im using the fuck out of!!! That one on ebay is an og one ive got all mine from him.if you got the cash snatch that shit!! Otherwise get at me for a trade.lol
BEDAROCINK.WEEBLY.COM or find me on FACEBOOK under the name "TED BEDAROC"... anyone in nor cal get at me for any and all graff supplies...
martha stewart with grog chrome
silver fats
and lately ive had a thing for decos, in lieu of a pentel 100


text:
Summary: Fibrinogen beta and gamma chains, C-terminal globular domain
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Fibrinogen Edit Wikipedia article
|This article may be in need of reorganization to comply with Wikipedia's layout guidelines. (February 2012) (Learn how and when to remove this template message)
|fibrinogen alpha chain
|Other data
|Chr. 4 q28
|fibrinogen beta chain
|Other data
|Chr. 4 q28
|Fibrinogen gamma chain
|Other data
|Chr. 4 q28
|Fibrinogen alpha/beta chain family
crystal structure of native chicken fibrinogen with two different bound ligands
|Fibrinogen alpha C domain
|Fibrinogen beta and gamma chains, C-terminal globular domain
crystal structure of native chicken fibrinogen with two different bound ligands
|Pfam clan
Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Å. The length of the dried molecule is 475 ± 25 Å.[2]
The fibrinogen molecule is a soluble, large, and complex 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. It has a rod-like shape with dimensions of 9 × 47.5 × 6 nm and it shows a negative net charge at physiological pH (IP at pH 5.2).[3] Fibrinogen is synthesized in the liver by the hepatocytes.[3] The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method).
During normal blood coagulation, a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin. Thrombin then converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by factor XIII to form a blood clot. FXIIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells.[4] Both the activation of factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin.[4] Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis.[5] Research from 2011 has shown that fibrin plays a key role in the inflammatory response and development of rheumatoid arthritis.[6][citation needed]
In its natural form, fibrinogen can form bridges between platelets, by binding to their GpIIb/IIIa surface membrane proteins; however, its major function is as the precursor to fibrin.
Fibrinogen, the principal protein of vertebrate blood clotting, is a hexamer, containing two sets of three different chains (α, β, and γ), linked to each other by disulfide bonds. The N-terminal sections of these three chains contain the cysteines that participate in the cross-linking of the chains. The C-terminal parts of the α, β and γ chains contain a domain of about 225 amino-acid residues, which can function as a molecular recognition unit. In fibrinogen as well as in angiopoietin, this domain is implicated in protein-protein interactions. In lectins, such as mammalian ficolins and invertebrate tachylectin 5A, the fibrinogen C-terminal domain binds carbohydrates. On the fibrinogen α and β chains, there is a small peptide sequence (called a fibrinopeptide). These small peptides are what prevent fibrinogen from spontaneously forming polymers with itself.[7]
The conversion of fibrinogen to fibrin occurs in several steps. First, thrombin cleaves fibrinopeptide A and B located on the N-terminus of the fibrinogen alpha and beta chains respectively.[8] The resulting fibrin monomers polymerize end to end to from protofibrils, which in turn associate laterally to form fibrin fibers.[9] In a final step, the fibrin fibers associate to form the fibrin gel.[10]
Fibrinogen deficiency
Congenital fibrinogen deficiency (afibrinogenemia) or disturbed function of fibrinogen has been described in a few cases.[11]
It can lead to either bleeding or thromboembolic complications, or is clinically without pathological findings. More common are acquired deficiency stages that can be detected by laboratory tests in blood plasma or in whole blood by means of thrombelastometry.[12] Acquired deficiency is found after hemodilution, blood losses and/or consumption such as in trauma patients, during some phases of disseminated intravascular coagulation (DIC), and also in sepsis. In patients with fibrinogen deficiency, the correction of bleeding is possible by infusion of fresh frozen plasma (FFP), cryoprecipitate (a fibrinogen-rich plasma fraction) or by fibrinogen concentrates. There is increasing evidence that correction of fibrinogen deficiency or fibrinogen polymerization disorders is very important in patients with bleeding.[13]
Diagnostic use
Fibrinogen level can be measured in venous blood. Normal levels are about 1.5-3 g/L, depending on the method used. In typical circumstances, fibrinogen is measured in citrated plasma samples in the laboratory; however, the analysis of whole-blood samples by use of thromboelastometry (platelet function is inhibited with cytochalasin D) is also possible.[12] Higher levels are, amongst others, associated with cardiovascular disease (>3.43 g/L). It may be elevated in any form of inflammation, as it is an acute-phase protein; for example, it is especially apparent in human gingival tissue during the initial phase of periodontal disease.[14] Fibrinogen levels increase in pregnancy to an average of 4.5 g/l, compared to an average of 3 g/l in non-pregnant people.[15]
It is used in veterinary medicine as an inflammatory marker: In horses, a level above the normal range of 1.0-4.0 g/L suggests some degree of systemic inflammatory response.[citation needed]
Low levels of fibrinogen can indicate a systemic activation of the clotting system, with consumption of clotting factors faster than synthesis. This excessive clotting factor consumption condition is known as disseminated intravascular coagulation or "DIC." DIC can be difficult to diagnose, but a strong clue is low fibrinogen levels in the setting of prolonged clotting times (PT or aPTT), in the context of acute critical illness such as sepsis or trauma. Besides low fibrinogen level, fibrin polymerization disorders that can be induced by several factors, including plasma expanders, can also lead to severe bleeding problems.[12] Fibrin polymerization disorders can be detected by viscoelastic methods such as thrombelastometry.[12]
A fibrinogen uptake test or fibrinogen scan is a test that was formerly used to detect deep vein thrombosis. In this method, radioactively labeled fibrinogen, typically with radioiodine, is given which is incorporated in the thrombus. The thrombus can then be detected by scintigraphy.
Prognostic use
Fibrinogen level has been proposed as a predictor of hemorrhagic complications during catheter-directed trombolysis for acute or subacute peripheral native artery and arterial bypass occlusions.[16] However, a systematic review of the available literature until January 2016 found that the predictive value of plasma fibrinogen level for predicting hemorrhagic complications after catheter-directed thrombolysis is unproven.[17]
- ^ PDB: 1FZC; Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF (June 1998). "Crystal structure of fragment double-D from human fibrin with two different bound ligands". Biochemistry. 37 (24): 8637–42. doi:10.1021/bi9804129. PMID 9628725.
- ^ Hall, Ph.D., Cecil E.; HENRY S. SLAYTER (18 August 1958). "The Fibrinogen Molecule: Its Size, Shape, and Mode of Polymerization" (PDF). The Journal of Biophysical and Biochemical Cytology. Plate 1. Cambridge, M: e Department of Biology, Massachusetts Institute of Technology. 5 (1): 11–6. doi:10.1083/jcb.5.1.11. PMC 2224630. PMID 13630928. Retrieved 24 May 2014.
- ^ a b Marucco, Arianna; et al. (2013). "Interaction of fibrinogen and albumin with titanium dioxide nanoparticles of different crystalline phases" (PDF). Journal of Physics. Conference Series. 429 (1). Retrieved 24 May 2014.
- ^ a b Muszbek L, Bagoly Z, Bereczky Z, Katona E (July 2008). "The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis". Cardiovascular & Hematological Agents in Medicinal Chemistry. 6 (3): 190–205. doi:10.2174/187152508784871990. PMID 18673233.
- ^ Kaiser B (2003). "DX-9065a, a direct inhibitor of factor Xa". Cardiovascular Drug Reviews. 21 (2): 91–104. doi:10.1111/j.1527-3466.2003.tb00108.x. PMID 12847561.
- ^ Gilliam BE; Reed, Melinda R; Chauhan, Anil K; Dehlendorf, Amanda B; Moore, Terry L (2011). "Evidence of Fibrinogen as a Target of Citrullination in IgM Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis". Pediatric Rheumatology. 9 (8): xx–xx. doi:10.1186/1546-0096-9-8. ISSN 1546-0096. PMC 3071779. PMID 21439056.
- ^ PDOC00445 Fibrinogen C-terminal domain in PROSITE
- ^ Blombäck B, Hessel B, Hogg D, Therkildsen L (October 1978). "A two-step fibrinogen--fibrin transition in blood coagulation". Nature. 275 (5680): 501–5. doi:10.1038/275501a0. PMID 692730.
- ^ Hermans J, McDonagh J (January 1982). "Fibrin: structure and interactions". Semin. Thromb. Hemost. 8 (1): 11–24. doi:10.1055/s-2007-1005039. PMID 7036348.
- ^ Lorand L, Credo RB; John W. Fenton; Kenneth G. Mann (1977). "Thrombin and fibrin stabilization". In Mann KG; Lundblad RL; Fenton J. Chemistry and Biology of Thrombin. Ann Arbor, Mich: Ann Arbor Science Publishers. pp. 311–323. ISBN 0-250-40160-6.
- ^ Acharya SS, Dimichele DM (November 2008). "Rare inherited disorders of fibrinogen". Haemophilia. 14 (6): 1151–8. doi:10.1111/j.1365-2516.2008.01831.x. PMID 19141154.
- ^ a b c d Lang T, Johanning K, Metzler H, Piepenbrock S, Solomon C, Rahe-Meyer N, Tanaka KA (March 2009). "The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia". Anesthesia and Analgesia. 108 (3): 751–8. doi:10.1213/ane.0b013e3181966675. PMID 19224779.
- ^ Fries D, Innerhofer P, Schobersberger W (April 2009). "Time for changing coagulation management in trauma-related massive bleeding". Current Opinion in Anaesthesiology. 22 (2): 267–74. doi:10.1097/ACO.0b013e32832678d9. PMID 19390253.
- ^ Page RC, Schroeder HE (March 1976). "Pathogenesis of inflammatory periodontal disease. A summary of current work". Lab. Invest. 34 (3): 235–49. PMID 765622.
- ^ Salvi, Vinita (2003). Medical and Surgical Diagnostic Disorders in Pregnancy. Jaypee Brothers Publishers. p. 5. ISBN 978-81-8061-090-5.
- ^ "Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE trial". Annals of Surgery. 220 (3): 251–266; discussion 266–268. 1994-09-01. ISSN 0003-4932. PMC 1234376. PMID 8092895.
- ^ Poorthuis, Michiel H. F.; Brand, Eelco C.; Hazenberg, Constantijn E. V. B.; Schutgens, Roger E. G.; Westerink, Jan; Moll, Frans L.; de Borst, Gert J. (2017-03-05). "Plasma fibrinogen level as a potential predictor of hemorrhagic complications after catheter-directed thrombolysis for peripheral arterial occlusions". Journal of Vascular Surgery. doi:10.1016/j.jvs.2016.11.025. ISSN 1097-6809. PMID 28274749.
External links
- Jennifer McDowall/Interpro: Protein Of The Month: Fibrinogen.
- D'Eustachio/reactome: fibrinogen → fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
- Khan Academy Medicine (on YouTube): Clotting 1 - How do we make blood clots?
|Wikimedia Commons has media related to Fibrinogen.
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Fibrinogen beta and gamma chains, C-terminal globular domain Provide feedback
No Pfam abstract.
Literature references
Spraggon G, Everse SJ, Doolittle RF , Nature 1997;389:455-462.: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. PUBMED:9333233 EPMC:9333233
Internal database links
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002181
Fibrinogen plays key roles in both blood clotting and platelet aggregation. During blood clot formation, the conversion of soluble fibrinogen to insoluble fibrin is triggered by thrombin, resulting in the polymerisation of fibrin, which forms a soft clot; this is then converted to a hard clot by factor XIIIA, which cross-links fibrin molecules. Platelet aggregation involves the binding of the platelet protein receptor integrin alpha(IIb)-beta(3) to the C-terminal D domain of fibrinogen [PUBMED:12799374]. In addition to platelet aggregation, platelet-fibrinogen interaction mediates both adhesion and fibrin clot retraction.
Fibrinogen occurs as a dimer, where each monomer is composed of three non-identical chains, alpha, beta and gamma, linked together by several disulphide bonds [PUBMED:11460466]. The N-terminals of all six chains come together to form the centre of the molecule (E domain), from which the monomers extend in opposite directions as coiled coils, followed by C-terminal globular domains (D domains). Therefore, the domain composition is: D-coil-E-coil-D. At each end, the C-terminal of the alpha chain extends beyond the D domain as a protuberance that is important for cross-linking the molecule.
During clot formation, the N-terminal fragments of the alpha and beta chains (within the E domain) in fibrinogen are cleaved by thrombin, releasing fibrinopeptides A and B, respectively, and producing fibrin. This cleavage results in the exposure of four binding sites on the E domain, each of which can bind to a D domain from different fibrin molecules. The binding of fibrin molecules produces a polymer consisting of a lattice network of fibrins that form a long, branching, flexible fibre [PUBMED:11593005, PUBMED:15837518]. Fibrin fibres interact with platelets to increase the size of the clot, as well as with several different proteins and cells, thereby promoting the inflammatory response and concentrating the cells required for wound repair at the site of damage.
This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PUBMED:12396010].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- a link to the page in the Pfam site showing information about the sequence that the graphic describes
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Note that you can see the family page for a particular domain by clicking on the graphic. You can also choose to see all sequences which have a given architecture by clicking on the Show link in each row.
Finally, because some families can be found in a very large number of architectures, we load only the first fifty architectures by default. If you want to see more architectures, click the button at the bottom of the page to load the next set.
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Pfam Clan
This family is a member of clan Fibrinogen_C (CL0422), which has the following description:
This is a collection of families with C-terminal domains that are of similar structure.
The clan contains the following 2 members:COLFI Fibrinogen_C
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
There are various ways to view or download the sequence alignments that we store. We provide several sequence viewers and a plain-text Stockholm-format file for download.
Alignment types
We make a range of alignments for each Pfam-A family:
- seed
- the curated alignment from which the HMM for the family is built
- full
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- UniProt
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- meta
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- jalview
- a Java applet developed at the University of Dundee. You will need Java installed before running jalview
- an HTML page showing the whole alignment.Please note: full Pfam alignments can be very large. These HTML views are extremely large and often cause problems for browsers. Please use either jalview or the Pfam viewer if you have trouble viewing the HTML version
- PP/Heatmap
- an HTML-based representation of the alignment, coloured according to the posterior-probability (PP) values from the HMM. As for the standard HTML view, heatmap alignments can also be very large and slow to render.
You can download (or view in your browser) a text representation of a Pfam alignment in various formats:
- Selex
- Stockholm
You can also change the order in which sequences are listed in the alignment, change how insertions are represented, alter the characters that are used to represent gaps in sequences and, finally, choose whether to download the alignment or to view it in your browser directly.
You may find that large alignments cause problems for the viewers and the reformatting tool, so we also provide all alignments in Stockholm format. You can download either the plain text alignment, or a gzipped version of it.
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Previous IDs:
|Sonnhammer ELL
|Number in seed:
|Number in full:
|Average length of the domain:
|186.20 aa
|Average identity of full alignment:
|34 %
|Average coverage of the sequence by the domain:
|40.76 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
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The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There are 4 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Fibrinogen_C domain has been found. There are 281 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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text: I guess we know now why the people at the rehab never bothered to call the coroner when That 70's Show actress Lisa Robin Kelly died. Lisa died at 8am but the coroner only found out about the death at noon when he saw tabloid reports online. The rehab place said Lisa died of an embolism. Nope. According to the coroner Lisa died of an accidental drug overdose. Yeah, while in rehab. She had a bunch of drugs in her system. That is quite the rehab facility. Lisa died back in August and originally the toxicology report was supposed to take six to eight weeks. Instead, it took almost five months. The rehab facility did say she was taking rehab drugs to get her off all the other drugs. I smell a big lawsuit.


text:
Washington : Government Printing Office
Page 1570
Order 2508 (an order by which the Secretary of the Interior delegates certain authority to the Commissioner of Indian Affairs), as amended, is further amended in section 18(a) by adding new subparagraph (3) and renumbering the existing subparagraphs (3) and (4) accordingly. The addition authorizes the Commissioner to exercise the Secretary's authority to approve disenrollment actions. As so amended, section 18(a) reads as follows:
Tribal ordinances, resolutions, constitutions, and charters. (a) The Commissioner may exercise the authority of the Secretary with respect to those matters set forth in subparagraphs (1), (2), and (3), subject to the limitations set forth in subparagraphs (4) and (5), of this paragraph:
(1) Tribal ordinances and resolutions, and contracts, including expenditures under such contracts where approval of such expenditures is required, which are adopted, enacted, or negotiated by Indian
Page 1571
tribal governing bodies pursuant to constitutions approved under section 16 or charters issued under section 17 of the act of June 18, 1934 (48 Stat. 984; 25 U.S.C., 1964 ed., secs. 461 et seq.), as amended, the act of May 1, 1936 (49 Stat. 1250; 25 U.S.C., 1964 ed., sec. 473a), and the act of June 26, 1936 (49 Stat. 1967; 25 U.S.C., 1964 ed., sec. 503), or pursuant to the constitutions adopted and approved without regard to the provisions of these acts:
(2) Tribal ordinances relating to law and order adopted pursuant to 25 CFR 11.1(e).
(3) Tribal enactments disenrolling persons found not to meet the established enrollment criteria. The Commissioner's approval of such action shall be subject to appeal to the Secretary of the Interior.
(4) The Commissioner shall forward to the Secretary, with a recommendation, ordinances, resolutions, or contracts which, in the opinion of the Commissioner are: Inconsistent with an Act of Congress or with a treaty or with the tribal constitution or charter under which the ordinance, resolution, or contract was adopted, enacted, or negotiated; or should be disapproved or rescinded for any other reason.
(5) Notwithstanding the provisions of section 25 of this order, the Commissioner shall not redelegate the authority granted in this paragraph to any officer or employee who pursuant to a tribal constitution or charter passes upon ordinances, resolutions, or contracts.
Secretary of the Interior.


text:
Monday Morning Quarterback Week 12
The Good
The Bad
Houston TexansDetroit Lions
Matt Schaub continued his stellar play, throwing for 315 yards and dictating the pace of the game with his consistent and accurate throws. Matthew Stafford had a solid day, throwing for 441 yards and 2 touchdowns. He did not throw an interception.
Schaub only threw one touchdown pass and he was also intercepted once. Stafford had plenty of chances to build a bigger lead during the course of the game, but he was not able to add to the Texans' early deficit.
Washington RedskinsDallas Cowboys
Another spectacular performance for RGIII. He went into Cowboys Stadium and dominated the game. He completed 20-of-28 passes for 311 yards with 4 touchdowns. Tony Romo did not get any help from his running game and he threw for 441 yards and 3 touchdowns.
Romo did everything he could to get the Cowboys a home win, but he threw 2 key interceptions that gave the Redskins control of the game.
New England PatriotsNew York Jets
Tom Brady had plenty of help from the Patriots' defense and special teams, but he held up his end of the bargain quite nicely. He threw for 323 yards and 3 TDs and he did not throw an interception. He was in complete control and the Jets could not press him.
Another disastrous performance from Mark Sanchez. He threw for 306 yards, but his second-quarter fumble in which he ran into his own offensive lineman and then fumbled the ball where it was returned for a touchdown will not be lived down easily.
Chicago BearsMinnesota Vikings
The Bears were thrilled to get Jay Cutler back after he missed the Week 11 game at San Francisco. Cutler moved well, threw the ball accurately and allowed the Bears to take charge against the division rivals. He completed 23-of-31 passes.
Christian Ponder was in over his head against a very angry Bears defense. He was held to 159 yards and threw an interception that set the Bears up deep in Minnesota territory.
Cincinnati BengalsOakland Raiders
Andy Dalton is back on top of his game after a tough stretch in the middle of the season. Dalton was accurate in dissecting the Oakland defense. He threw 3 touchdown passes and he did not throw an interception.
Carson Palmer was inspired to have a great game against his former team, but it didn't work out that way. Palmer was under pressure throughout and he only threw for 146 yards. He threw just 1 touchdown pass and he was also intercepted.
Cleveland BrownsPittsburgh Steelers
There haven't been many exceptional moments for the Browns in recent years, but registering an upset win over the Steelers was huge. Rookie Brandon Weeden was competitive enough to throw for 158 yards and 1 TD pass.
It's not just about experience that helps a quarterback play effective football. Charlie Batch has plenty of experience but he can't throw the ball well at this point in his career. He threw for 199 yards, but his 3 interceptions helped ruin the day for the Steelers (along with a boatload of fumbles by Steelers running backs). Weeden suffered a concussion at the end of his winning performance.
Indianapolis ColtsBuffalo Bills
The Colts did not get the spectacular show from rookie quarterback Andrew Luck that they have come to expect, but they did get a winning performance. He threw for 240 yards and a touchdown and he only threw 1 interception.
Ryan Fitzpatrick had plenty of opportunities to get his team back in the game, but he was not quite able to deliver. Fitzpatrick missed some throws that might have allowed them to tie the game in the second half.
Jacksonville JaguarsTennessee Titans
Chad Henne is making the most of his opportunity. After a spectacular showing in Week 11 against Houston, Henne led the Jaguars to a victory by throwing or 261 yards.
Jake Locker also threw for 261 yards and was able to direct the Tennessee offense up and down the field. However, the Titans were forced to settle for field goals and that kept them from winning this game.
Denver BroncosKansas City Chiefs
The Chiefs may be struggling, but it's never easy to go on the road and earn a division win. Peyton Manning knows this as well as anybody and while he did not have his best statistical game, he threw for 285 yards and 2 touchdowns to lead the Broncos to the victory.
The quarterback play has been an issue for the Chiefs all season. This time, Brady Quinn got the call and he was inconsistent at best in throwing for 126 yards and 1 interception.
Miami DolphinsSeattle Seahawks
Ryan Tannehill led a fourth-quarter rally that allowed the Dolphins to tie the game and then keyed a last-minute drive that allowed them to win the game with a field goal as time ran out. Tannehill completed 18-of-26 passes and threw for 253 yards.
Russell Wilson had an excellent statistical game, completing 21-of-27 passes for 224 yards with 2 TDs and no interceptions, but he could not direct a late drive late in the game that would have allowed the Seahawks to regain the lead after the Dolphins tied the game.
Atlanta FalconsTampa Bay Buccaneers
Matt Ryan continues to throw the ball with velocity and accuracy. He was under pressure throughout the game, but he completed 26-of-32 passes for 353 yards. He threw a spectacular 80-yard touchdown pass to wide receiver Julio Jones.
Josh Freeman had a decent game, completing 19-of-30 passes for 256 yards. However, he missed several open receivers throughout the game.
Baltimore RavensSan Diego Chargers
The Ravens struggled for much of the day against a desperate Chargers team, but Joe Flacco kept pushing the attack. He threw a touchdown pass in the fourth quarter, directed the game-tying drive and then threw an overtime pass to Torrey Smith that set up the game-winning field goal in overtime.
Philip Rivers threw the ball accurately and completed 23-of-36 passes, but he couldn't do enough in the fourth quarter to get the Chargers a win they needed for self-respect.
St. Louis RamsArizona Cardinals
Sam Bradford did not have a great statistical game, but he threw for 205 yards and 2 touchdowns in leading the Rams to the road win. Bradford only threw 1 interception.
Ryan Lindley was given his first start and he had little to work with. Lindley was forced to put the ball up 52 times. He threw for 312 yards, but he threw 4 interceptions.
San Francisco 49ersNew Orleans Saints
Colin Kaepernick picked up his second win in as many starts. While he is still learning, he is producing under pressure. He completed 16-of-25 passes for 231 yards and threw a TD pass in leading the Niners to a key road win.
Drew Brees threw for 267 yards and 3 touchdowns, but he was under pressure throughout the game and the Saints only scored 1 touchdown in the second half.
New York JetsGreen Bay Packers
The Giants came back with a strong effort following their bye week. Eli Manning was not perfect – he completed 16-of-30 passes – but he threw for 249 yards and 3 touchdowns while quieting critics who claimed he had a tired arm.
The Giants defense put pressure on Aaron Rodgers throughout the game and he was unable to lead the Packers attack. While he threw a 61-yard touchdown pass to Jordy Nelson in the first quarter, he was unable to get the Packers back in the end zone the rest of the game.


text:
I'll be answering ten questions each month...
and if your question is chosen, I'll post a personalized response!
Submit Your Question
- from Mexico City, Mexico City
Yes, our candy clay recipe is done with Candy Melts Candy, which is a type of confectionary coating. Here is the recipe: http://bakedecoratecelebrate.com/recipes/candyclay.cfm
Return to all questions


text:
Guys and Gals--
Time has come to thin out the quiver a bit. I've got 4 boards for sale (email me and I will send pictures):
1. Stretch Bat tail quad - 6'4" x 19.25" x 2.5" - asking $300 (comes with board bag and 2 sets of future quad fins) - board is in good condition, the left tip of the tail was damaged on the airline back from Costa Rica and professionally repaired.
2. Channel Islands Biscut - 6'0" x 21" x 3" - asking $450 - board is in excellent shape, no dings, only a few pressure marks on the deck but only used 2 or 3 times, looks nice and new, comes with FCS GAM fins
3. Hatteras Glass (step-up board) - 6'7" x 19 3/4" x 2 5/8" - asking $300 - great travel board, only ridden once, no dings, no damage, comes with FCS fins (Hatteras Glass boards are shaped by Joe Shriver of WRV and glassed by Randy Hall at the Rodanthe Surf Shop in the outer banks)
4. Larry Mayo Single Fin - 6'11" - asking $400 - beautiful eggplant resin tint - not sure about the width or thickness but estimate 21" wide and 2 3/4" thick - new condition only ridden once or twice - no dings, no damage, no pressure marks on the deck - you can check out his single fins on his website mayosurfboards.com - comes with Greenough 8" 4A flex fin.
I can ship but I can also meet almost anywhere from Ocean City, MD to Wilmington, NC
Thanks, John
Here are some pictures (See page 2 of this forum for additional pictures)...


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