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Locked Room International
#200: Celebrating 100 Impossible Crimes with Paul Halter's The Vampire Tree (1996) [trans. John Pugmire 2016]
This, my 200th post on this blog, will also be the 100th to be tagged with the subject 'Impossible Crimes' and — since my very first was a review of Paul Halter's The Phantom Passage — I thought I'd hold this milestone to look at the most recent Halter translation from John Pugmire's Locked Room International, which goes by the English title The Vampire Tree. I will probably do this at some length, though without mentioning specifics past the 25% mark, and with a brief mention of only one slight spoiler, signposted in advance. So, let's get into it…
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#150: The House That Kills (1932) by Noel Vindry [trans. John Pugmire 2015]
Aaaah, the debut novels of celebrated authors. Would anyone read It Walks by Night and predict The Problem of the Green Capsule or Till Death Do Us Part? Does The Mysterious Affair at Styles in any way prepare you for The Moving Finger, or for Crooked House? Often it's a challenge to look back on the opening salvo of a career that would go on to become notable and find any vestige of that in those first few hundred pages, and it can be even harder when — as in the case of Noel Vindry's The House That Kills — you're waiting 80 years to read it in your native language and are told up front of the author's own huge contribution to the genre. Frankly, it needs to be The Usual Suspects mixed with The Mystery of the Yellow Room (spoilers for that in this, incidentally) as rewritten by David Mamet…and even then it probably won't match the hype.
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#148: So, Like, What Is an Impossible Crime or a Locked Room Mystery?
Recent experiences of reading Darkness at Pemberley by T.H. White and What a Body! by Alan Green — oh my days, I've only just noticed that they're both named after colours… — have made me wonder on the above question. See, both are listed here, on a compendium of the best ever locked room mysteries voted on by an international collection of people who know about this stuff, and both are listed here, on a rundown of the favourite locked room mysteries by resident blogosphere expert TomCat…yet personally, in the face of public opinion from such well-informed and respected sources, I'm reluctant to consider either of them as locked room mysteries. Even taking my famously contrary nature out of the equation…what the hell?
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#112: The Howling Beast (1934) by Noel Vindry [trans. John Pugmire 2016]
Disclosure: I proof-read this book for Locked Room International in April 2016.
After many years reading, talking about, reviewing, and now blogging on the subject of detective fiction I am presented with a real difficulty here: I honestly don't know quite what to write about Noel Vindry's classic The Howling Beast for fear of giving anything away. It is a balancing act of a book that, while probably not completely successful by today's standards, is hugely enjoyable and absolutely something that those who count themselves as puzzle fans or lay claim to an interest in the emergence and development of detective fiction really should read. And I'm not just being vague here because I don't want to criticise it — I really enjoyed it, and there's one key thing it does absolutely brilliantly, and I'm especially keen to preserve that for those of you who should experience this pure. So, with that out of the way, here goes.
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#103: Paul Halter Day – III: The Round-Up
Well, as 60th birthdays go, I hope mine is this much fun. And so as Paul Halter Day comes to an end – and given that you've already checked out my two posts on the beginning of the Locked Room International enterprise and then some unapologetic fanboying on Halter's impossible crime mantle-bearing – here's the round-up of what others who were generous enough to get involved had to say.
First up, and with thanks for his not taking legal action over me stealing his Crimes of the Century round-up idea for this post, Rich at Past Offences tackled The Demon of Dartmoor, his first toe into the Halter Pool (see what I did there?), and liked what he found:
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#102: Paul Halter Day – II: The Impossibility of More Impossibilities
Declaring that the detective novel was the only form of literature that put the reader to work, [S.S. van Dine] argued that "a deduction game emphasising fair play within a limited setting" would be the story structure with the best potential to result in masterpiece mystery stories […] But when the elements of the game are too severely limited and the building materials are all the same, only the first few builders will get all the glory and there will be an over-abundance of similar novels…
—Soji Shimada, in his introduction to The Moai Island Puzzle
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#101: Paul Halter Day – I: An Epistle of Paul the Impossible
If I ran one of those clickbait-style websites, I would have been teasing this for at least a week now as the tautology of a 'world exclusive never-before-seen Paul Halter translation'. I mean, it is exactly that, but that's not the point.
In order to help with the acknowledgement of Paul Halter's 60th birthday, John Pugmire — perhaps better known under his stage name of Locked Room International — has, with M. Halter's blessing, sent me a copy of the letter he received from Halter when mutual friend Roland Lacourbe first showed Halter the English translation John had done of his debut novel, The Fourth Door. Lacourbe is, of course, the acknowledged overlord of the French impossible crime scene and compiler of the encyclopaedic reference 1001 Chambres Closes, the French equivalent of Robert Adey's English language rundown of all things fictional and impossible, Locked Room Murders.
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#98: One week until Paul Halter Day!


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Hastings has three good reasons for doing something special: first, this year's event marks the beginning of the centenary celebrations of the tournament that started the great Hastings tradition, when all the world's great masters gathered and Harry Nelson Pillsbury snatched first prize ahead of Emanuel Lasker and Wilhelm Steinitz. Secondly, it is the 50th anniversary of the death of Vera Menchik, the first woman world champion. And thirdly, though it is churlish to admit it, top women players are considerably less expensive than the top males, and Hastings is, sadly, once again without any major commercial sponsor.
The main centenary celebrations will take place in August, with a grand banquet, a major international tournament, and a production of Chess - The Musical all on the agenda. The present event, therefore, is officially dedicated to the memory of Vera Menchik, the first woman to compete successfully against men. Russian by birth, Czech by nationality and English by marriage, Menchik lived for many years in Hastings, where she was coached by the Hungarian grandmaster Geza Maroczy who, to comple te the chain of coincidence, was the winner of the second section at Hastings 1895.
Play takes place each day in the Premier tournament at the Cinque Ports Hotel, Bohemia Road, Hastings (0424 439222), from today until 5 January, beginning at 2pm.
To end where it all began, here's a game from Hastings 1895 won by Vera Menchik's future trainer against one of England's best, the Rev James Owen. Maroczy's opening play is years ahead of its time, and his far-sighted combination beginning with 28...Nxg3! showed excellent judgement.
White missed several chances to put up a better fight, notably 32.Qe3 and 39.Nc3, but they would have denied us the attractive mating finish.
White: Owen Black: Maroczy 1 Nf3 g6 22 Kh2 Qb6
2 d4 Bg7 23 a3 Nc5
3 e3 d6 24 Bc2 b3
4 Bd3 e5 25 Be4 Nf5
5 c3 Bg4 26 g4 fxg3+ 6 h3 Bxf3 27 fxg3 Nxe4
7 Qxf3 c6 28 Qxe4 Nxg3
8 Na3 Nd7 29 Kxg3 Rxf1
9 Nc4 Qc7 30 Be3 Rxa1
10 d5 Nc5 31 Bxb6 Rxb6
11 Bc2 Ne7 32 h4 Bh6
12 e4 cxd5 33 Kg2 Ra2
13 exd5 Nd7 34 Qg4 Rxb2+ 14 Bb3 b5 35 Kh3 Bf4
15 Ne3 f5 36 Qc8+ Kg7
16 Qe2 Rb8 37 Qc7+ Kh6
17 0-0 f4 38 Qxb6 Rd2
18 Nc2 a5 39 Nxd6 Kh5
19 Na3 Qc5 40 Qg1 Rd3+ 20 c4 b4 41 Kg2 Rg3+ 21 Nb5 0-0 White resigns
William HartstonReuse content

subset: commoncrawl


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Chris Quinlan, Carl Peters, BMG LABTECH, Cary, NC, 07/2013
Endotoxins or lipopolysaccharides (LPS) are undesirable by-products of gram-negative bacterial preparations which are often found in plasmid DNA and ovalbumin preps. LPS is located in the outer membrane of the bacteria. Even trace amounts can cause a significant inflammatory response. The presence of endotoxin in the blood is called endotoxemia and can lead to sepsis in mammals. Therefore, endotoxins must be detected and eliminated from DNA and protein preparations to avoid unwanted responses in both in vivo and in vitro assays(1).
Fig. 1: Structure of the (3-deoxy-D-manno-octulosonic acid)2 Lipid A endotoxin from E. coli K-12. This figure is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported licenses and was adapted from: http://www.jlr.org/content/47/5/1097.full
Lonza has developed a kinetic endotoxin quantitation kit, which utilizes the coagulation properties of horseshoe crab blood in the presence of even low levels of endotoxin. The clottable protein has been isolated and is the active component of the Limulus Amebocyte Lysate (LAL). In the presence of endotoxin, a proenzyme in the LAL is activated which in turn cleaves a colorless peptide, Ac-Ile-Glu-Ala-Arg-pNA, resulting in the release of p-nitroaniline (pNA) which can be detected by continuous absorbance measurements at 405 nm(2) using the FLUOstar OPTIMA.
The concentration of the endotoxin is calculated by comparing the reaction times of samples to solutions containing known amounts of endotoxin.
The reaction time is typically defined as the time it takes to produce a 0.2 OD change in absorbance at 405 nm. The endotoxin concentration is inversely proportional to the reaction time so a smaller reaction time indicates a higher endotoxin concentration. The FLUOstar OPTIMA offers an easy way of measuring the Kinetic Endotoxin assay and in conjunction with MARS data analysis software can produce reaction times. MARS can also plot the standards and interpolate unknown samples from a linear regression or polynomial fit.
100 µl of standards and unknowns were measured for absorption at 405 nm in duplicate for a total of 100 min in plate mode (slow kinetics). A reading was taken every 2.5 min for a total of 40 points. Standards included 0.005, 0.05, 0.5 and 5.0 EU/ml, where EU = endotoxic units, a comparative measure of endotoxin activity. Since a baseline correction will be applied, blanks are not required for optimal assay performance.
The absorbance measurements(3) over time resulted in different signal curves (Fig. 2).
Fig. 2: Signal curves for several endotoxin samples. Figure is directly taken from the MARS data analysis software.
The kinetic data was evaluated utilizing the MARS data analysis software from BMG LABTECH. A baseline correction was applied to the raw data by subtracting cycle 1. The reaction time was calculated by performing a "time to threshold calculation" on the baseline corrected raw data. The threshold value was set for 0.2 OD producing the resulting reaction time in seconds. The average reaction time was plotted against concentration in EU/ml using a linear regression model (Fig. 3).
Fig. 3: Linear Regression Fit of Standards (log/log).
The resulting standard curve fit had an R2 value of 0.999 allowing for reliable interpolation of unknown samples (Table 1).
Table 1: Interpolated values for unknown samples.
Alternatively, the MARS data analysis software facilitated the plotting of standards utilizing a polynomial curve fit. It is recommended that the polynomial order be one less than the number of standards used. In this case a 3rd order polynomial fit could be used.
The MARS data analysis software further allows for the creation of a template for these and other sophisticated calculations (Fig. 4) to provide immediate data reduction and curve fits as soon as the assay is completed.
Fig. 4: Overview of standard curve fits in the MARS data analysis software.
The combination of the sensitive FLUOstar OPTIMA (Fig. 5) and the powerful MARS data analysis package allows for easy handling of complex assays such as the Kinetic-QCL Endotoxin kit from Lonza. The MARS data analysis package is standard with all BMG LABTECH readers and can be installed on other computers in the same lab at no additional charge. This assay kit can also be measured by all BMG LABTECH microplate readers that can measure absorbance including the Spectrostar Nano, PHERAstar FS, PHERAstar Plus, FLUOstar Omega, POLARstar Omega, POLARstar OPTIMA, NOVOstar and CLARIOstar.
Fig. 5: BMG LABTECH's multidetection microplate reader FLUOstar OPTIMA.


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Unique Wedding Photographer for Philadelphia, New York & Beyond
Hi! I'm Mike Allebach of Allebach Photography. I believe there is a reason you landed here. I tend to draw in some of the most creative couples.
People feel comfortable with me. On your wedding day you will feel calm as I capture YOU being yourself!
First visit our full website of awesome images and take a peek at Real Weddings
Featured in over 100 magazines and blogs including Philadelphia Inquirer, Wedding Bee, Offbeat Bride, Rock n Roll Bride & Philadelphia Wedding Magazine
Join our community of 16,000 fans to interact with and inspire you.
Destination: Quito, Ecuador: Closed June 10 - June 16
Our office will be closed June 10 through June 16 for my sister's destination wedding in Quito, Ecuador. Guess who is the wedding photographer? You guessed it!
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http://chimeralighting.com/wp-content/uploads/2016/03/chimera-lighting-logo.png 0 0 Adam Rodriguez http://chimeralighting.com/wp-content/uploads/2016/03/chimera-lighting-logo.png Adam Rodriguez2017-02-21 10:19:242017-02-21 10:19:24What lights can I use with a Video Pro Lightbank?
What lights can I use with a Video Pro Lightbank?
Video Pro lightbanks are designed for continuous lighting fixtures with a broad or open face design. A wide variety of speed rings are available, either in a dedicated mount for specific fixtures, or circular mount to fit in the barndoor / accessory ears of many lighting fixtures


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We're really sorry but we've sold out of this product and are unable to obtain more stock. In most cases this is usually because the manufacturer has discontinued the product. We don't want you to miss out though so here's some of our best selling products which are similar to what you are looking for. Take a look and you could just find the perfect item. Just a small point to note - they might not have the exact features as the product you initially wanted so please be sure to check the features before you buy.
HP ProLiant DL320e Gen8 v2 Server
This powerful single-processor server packs the latest computing technology and HP ProLiant Gen8 management features into a small unit at a low cost. Supporting the latest Intel® Xeon® Processor E3-1200 v3 Product Family, the HP ProLiant DL320e Gen8 v2 Server offers superior technology at a very affordable price. Designed for outstanding flexibility and versatility, the HP ProLiant DL320e Gen8 v2 supports a wide range of configuration options to efficiently handle your workloads, such as file/print, Web serving/hosting, networking, and security. Whether your organization is a large corporation or a small company, you can easily configure the HP ProLiant DL320e Gen8 v2 Server to match your business needs.


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The lion king [videorecording] / Walt Disney Pictures presents ; directed by Roger Allers and Rob Minkoff ; produced by Don Hahn ; screenplay by Irene Mecchi and Jonathan Roberts and Linda Woolverton ; songs by Tim Rice and Elton John ; original score composed and arranged by Hans Zimmer.
- Description: 1 videodisc (ca. 88 min.) : sd., col. ; 4 3/4 in.
- Edition: DVD ed.
- Publisher: [Burbank, Calif.] : Walt Disney Studios Home Entertainment : 2011.
Available copies
- 3 of 16 copies available at NOBLE (All Libraries).
Current holds
1 current hold with 16 total copies.
|Call Number
|Due Date
|Children's DVDs
|juv LIO (Text to Phone)
|Checked out
|Everett - Parlin Memorial
|Children's Videos
|Children's DVD/ Lion (Text to Phone)
|Everett - Parlin Memorial
|Children's Videos
|Children's DVD/Lion (Text to Phone)
|Long Overdue
|Everett - Parlin Memorial
|Children's Videos
|Children's DVD/Lion (Text to Phone)
|Long Overdue
|Everett - Parlin Memorial
|Children's Videos
|Children's DVD/Lion (Text to Phone)
|Long Overdue
|Children's DVDs
|J/DVD/ Lion (Text to Phone)
|Checked out
|Children's DVD
|RENTAL CHILD DVD FEATURE LION (Marblehead pickup only) (Text to Phone)
|Checked out
|Children's DVDs
|J DVD L (Text to Phone)
|Merrimack College
|DVD (2nd)
|PN1997 .L566 2011 (DVD) (Text to Phone)
|Merrimack College
|World Language DVD (2nd)
|[World Language] PN1997 .L566 2011 (DVD) (Text to Phone)
|Next 10 »
Content descriptions
|General Note:
| Originally released as a motion picture in 1994.
Bonus features: The Lion King: a memoir to Don Hahn ; Learn how to take your favorite movies on the go ; Discover Blu-ray 3D with Timon & Pumbaa.
|Creation/Production Credits Note:
| Art direction, Andy Gaskill ; production design, Chris Sanders ; artistic coordinator, Randy Fullmer ; supervising editors, Tom Finan and John Carnochan ; artistic supervisors, Brenda Chapman, Dan St. Pierre, Doug Ball, Vera Lanpher, Scott Santoro, Scott F. Johnston.
|Participant or Performer Note:
| Voices: Jonathan Taylor Thomas (Young Simba), Matthew Broderick (Adult Simba), James Earl Jones (Mufasa), Jeremy Irons (Scar), Moira Kelly (Adult Nala), Niketa Calame (Young Nala), Ernie Sabella (Pumbaa), Nathan Lane (Timon), Robert Guillaume (Rafiki), Rowan Atkinson (Zazu), Madge Sinclair (Sarabi), Whoopi Goldberg (Shenzi), Cheech Marin (Banzai), Jim Cummings (Ed).
| The wait is over! For the first time ever, experience the majesty of Disney's epic animated masterpiece as it roars off the screen and into your living room. Embark on an extraordinary coming-of-age adventure as Simba, a lion cub who cannot wait to be king, searches for his destiny in the great 'Circle of Life.' Featuring pristine picture and sound and groundbreaking immersive bonus features.
|Target Audience Note:
| MPAA rating: G.
|System Details Note:
| DVD, region 1, widescreen (1.78:1) presentation ; 5.1 Disney enhanced home theater mix.
|Language Note:
| English, French or Spanish dialogue, optional French or Spanish subtitles ; English subtitles for the deaf and hard of hearing (SDH)
Search for related items by subject
|Lion > Juvenile drama.
Fathers and sons > Juvenile drama.
|Children's films.
Animated films.
Video recordings for the hearing impaired.
Minkoff, Rob. "The lion king." Burbank, Calif. : Walt Disney Studios Home Entertainment : 2011.
Link to this record:http://catalog.noblenet.org/eg/opac/record/3150359


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Sandton City Doppio Zero
Located in the new Protea Court section of Sandton City, this Doppio Zero has a beautiful gazebo style patio, covered in a glass awning with retractable glass panels, feel like you sitting outside in the mall.
Weekends are a buzz with early breakfasts and busy lunches and a perfect place for getaway dinners with great food, wine and friendly company.
Parking - Sandton Shopping Centre paid parking – closest entrance on Rivonia Road.
Booking policy - No bookings restrictions
Location & Contact Details
|Shop U310 Protea Court, Sandton City, Sandton.
|-26.11063, 28.053267
Opening Times
Sunday & Monday: 7.00 - 21.00 Tuesday - Thursday: 7.00 - 22.00 Friday & Saturday: 7.00 - 22.30
On The Map
Book Your Table
The cell number provided will be used to confirm your booking. Booking is not final until you receive confirmation from Doppio Zero.


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|Publication number
|Publication type
|Application number
|Publication date
|Jul 6, 1982
|Filing date
|Apr 9, 1981
|Priority date
|Jun 7, 1979
|Fee status
|Publication number
|James E. Young, Ralph S. Walker, James R. Chidester
|Original Assignee
|Young James E, Walker Ralph S, Chidester James R
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (3), Referenced by (31), Classifications (9), Legal Events (9)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a divisional of application Ser. No. 46,234 filed on June 7, 1979, now U. S. Pat. No. 4,278,083.
1. Field:
This invention pertains generally to intravenous catheter systems used in monitoring arterial functions and in the infusion of medical fluids to a patient. In particular, the invention relates to flow apparatus for controlling the flow of fluid at a desired continuous rate and to provide for intermittent, manually controlled larger flows of fluid to rapidly flush the catheter system.
2. State of the Art
Intravenous catheterization is a very useful procedure available for clinical monitoring of blood system and related parameters including arterial pulse waveform, stroke volume, heart rate, cardiac output, duration of systole, and systolic, diastolic and mean pressures. In addition, blood can be withdrawn for blood gas analysis.
To provide reliable operation over periods which may amount to several days, it has been found essential to flush the catheter continuously during its use with a regulated, continuous infusion of a relatively small flow of a liquid to prevent occlusion of the intravascular end of the catheter by blood coagulation. Continuous flushing systems have been proposed which utilize capillary tubes as flow resistors, with the flushing solution flowing therethrough under pressure. See, for example, U.S. Pat. No. 3,675,891, issued to Gordon S. Reynolds, et al. on Sept. 18, 1970, and an article appearing on pages 675-678 of the Journal of Thoracic and Cardiovascular Surgery, Volume 57, No. 5, May 1969.
Generally, the prior systems employed an objectionable large amount of apparatus including numerous stopcocks, with resulting loss of fidelity in the operation of the system. The device disclosed in U.S. Pat. No. 3,675,891 overcomes many of the deficiencies inherent in he earlier systems by providing a relatively small unitary piece of apparatus which was constructed so as to eliminate the use of all stopcocks. A resilient valve was provided to control a bypass around the capillary flow resistor, with the valve being operated by manually pulling a valve stem which extends longitudinally from the apparatus. The valve and step system of such device, however, has certain drawbacks. For example, the protruding stem is subject to entanglement in tubing, bedding, or other paraphenalia resulting in possible undesired opening of the valve or breakage of the valve stem so as to preclude proper operation of the device. The valve stem can also be broken by pulling the stem to one side or the other rather than longitudinal, and the valve has also been found to occasionally fail in the open position. In addition, the valve and stem system is generally difficult to operate with one hand, and for all practical purposes, requires two-handed manipulation.
3. Objectives
The principal objective of the present invention is to provide an improved regulating device which is reliable and easy to operate, as well as being simple in construction. A particular objective of the invention is to provide a small, streamlined device for connection in the catheter system which can be operated easily with one hand and which does not include stopcocks or stem actuated valves as in the devices of the prior art.
The above objectives are achieved in accordance with the present invention by providing a small, unitary, flow regulating device comprising a control member having an inlet means adapted to be connected to a source of a medical fluid and an outlet means adapted to be connected to an intravenous catheter. The control member is provided with a first passage connecting the inlet and outlet means for fluid flow communication therebetween, with at least a part of the first passage comprising a section of flexible conduit having valve control means positioned therein. A cylindrical, hollow, extension extends from the outlet means coaxially within and substantially to the midsection of the flexible conduit. The valve means is adapted to open and permit a flushing flow of liquid to pass through the first passage when the conduit is squeezed and to close and thereby stop the flushing flow of fluid when the conduit is released.
A second passage is provided in the control member. The second passage by-passes the valve means and connects the inlet and outlet means for flow communication therebetween. A flow restriction means is provided in the second passage to restrict the flow of fluid therethrough to a limited, continuous flow under a given upstream pressure.
Additional objects and features of the invention will become apparent from the following detailed description of a preferred embodiment, taken together with the accompanying drawing.
In the drawing:
FIG. 1 is a diagramatic illustration of a device in accordance with this invention in operative association with a catheter system which is inserted into the arm of a patient, the device itself being exaggerated for purposes of illustration;
FIG. 2 is a perspective view of a preferred embodiment of the device;
FIG. 3 is a cross-sectional view taken along line 3--3 of FIG. 2;
FIG. 4 is a cross-sectional view taken along line 4--4 of FIG. 3; with the plug member removed to more clearly show the undercut slots in the beveled end of the flow passage in which the plug member is positioned;
FIG. 5 is a pictorial cross-section of the end of the flow passage taken along line 4--4 of FIG. 3, with the flexible conduit omitted and with the end portion of the plug member being shown longitudinally exploded from its normal position to show the undercut slots and the ribs of the beveled end portion of the flow passage;
FIG. 6 is a vertical section of a modified version of the plug valve of FIG. 3.
The device of the present invention is adapted to be incorporated in various catheter systems. As used throughout the specification and claims, the term "catheter systems" is meant to include systems using catheters, cannulas, or other tubes inserted into the arterial system of a patient and used to monitor arterial functions and parameters as well as withdrawing blood from or infusing medical fluids into the arterial system.
By way of example, the flow control device is shown in the drawing and will be described herein as incorporated into a catheter system for monitoring arterial pressure and recording of arterial pulse waveforms. The catheter used in such a system is very thin, having an inside diameter of about one-half millimeter. The catheter must be maintained in open and operable condition for transmitting pressure pulses. The tendency for a blood clot or other occlusion to form at the end of the catheter positioned within the arterial system is greatly reduced by continuously infusing a sterile solution into the arterial system through the catheter in an amount which will not harm the patient but will retard the formation of occlusions in the catheter. Generally, depending on the size of the patient, from about 2 cc to about 7 cc of solution per hour has been found to be safe and beneficial.
In accordance with the present invention, means are also provided for manually flushing the catheter system from time to time with a momentary increase in the flow of solution through the catheter. The increased flow of fluid clears the catheter of any clots or occlusions which have formed or are being formed. In addition, the increased flow of fluid permits rapid clearing of all air from the system during the installation of the catheter into the arterial system of the patient, as will be discussed more fully hereinafter.
A preferred embodiment of the flow control device is shown in the six figures of the drawing, with similar components of the device being identified with the same reference numeral. The device comprises a control member 10, which as shown in FIG. 1 is adapted to be connected by tube 11 to a supply of a medical fluid in container 12. The control member 10 is also connected by tube 13 to a catheter which has been positioned within the arm of a patient 14. Means are provided for connecting the control member 10, in fluid flow communication through tube 15, to diagnostic apparatus (not shown in the drawing) which is capable of monitoring various arterial functions such as those mentioned previously. A variety of diagnostic apparatus is well known to the medical art and does not, per se, constitute part of the present invention. As will be more fully described hereinafter, the means which are provided for connecting tube 15 to control member 10 can also be used for hypodermic injections to the patient and for withdrawing of blood samples from the patient.
The construction of the control member 10 is best shown in FIGS. 2-5, and will be described with reference thereto. As illustrated, the control member 10 consists of a body member 16 having upstanding end caps 16a and 16b, respectively, such that in side elevation, the body member 16 has a broad, generally U-shaped profile, The end cap 16a is provided with inlet means for connecting the control member 10 to the tube 11 which, in turn, is connected to a supply of medical fluid, such as the container 12 shown in FIG. 1. The inlet means as shown in FIGS. 2 and 3 comprises a short piece of tubing 17 which is securely affixed to the end cap 16a at one of its ends and has a male fitting 18 attached to its other end. The fitting 18 is adapted to releasably engage a female fitting 19 on the end of tube 11. Of course, the order of the fittings could be reversed, i.e., the female fitting could be attached to the tubing 17, with the male fitting being on the end of tube 11. Various types of fittings, some being, as illustrated, adapted for interlocking engagement between lugs on the male fitting and internal thread-like receptacles on the female fitting, and some being adapted for simple sliding engagement, are commercially available for use in the present invention.
The other end cap 16b is provided with outlet means which is adapted to be connected to an intravenous catheter by way of an appropriate tube, such as tube 13 shown in FIG. 1. As illustrated in FIGS. 2 and 3, the outlet means comprises a fitting 20 which is adapted for connection to a mutually corresponding fitting on a fluid conveying tube leading to the catheter. The fitting 20 can be any of various type fittings conventionally used for connecting medical tubing together or to other medical apparatus. As shown, the fitting 20 is of the type having an internally threaded receptacle 20a (FIG. 3) adapted to receive a male fitting having lugs thereon for engagement with the threads of the receptacle.
The outlet means at end cap 16b preferably also includes a second fitting 20, which, as shown, is a male fitting having side lugs 21a which are adapted to releasably engage the threads of a mutually corresponding fitting on a tube, such as tube 15 shown in FIG. 1, for connecting the control member 10 to diagnostic apparatus capable of monitoring various functions such as blood pressure, etc., as mentioned previously. The fitting 21 could be of the female type such as fitting 20; however, inasmuch as the fitting on the diagnostic apparatus is likely to be of the female type, and connecting tubing conventionally has a male fitting at one end and a female fitting at the other end, it is advantageous to make the fitting 21 of the male type, as shown.
A fluid flow passage connects the inlet and outlet means in the end caps 16a and 16b of body member 10. As best illustrated in FIGS. 2 and 3, the flow passage comprises bores 16c and 16d through the respective end caps 16a and 16b which are in flow communication with the tube 17 and fitting 20, respectively. The end cap 16a has an inwardly facing hub 16e, which is adapted to receive one end of a flexible conduit 22 in tight coaxial fit thereover. A cylindrical hollow extension 16f extends inwardly from the end cap 16b to a distance up to about midway between the end caps 16a and 16b. The other end portion of the flexible conduit 22 fits coaxially over the cylindrical extension 16f. As illustrated, the cylindrical extension 16f is tapered slightly from its free end to the end thereof which joins the end cap 16b. The diameter of the cylindrical extension 16f at the base thereof adjacent to the end cap 16 b is sufficient to make a fluid tight seal with the other end of the flexible conduit 22. Thus, the conduit 22 connects the bores 16c and 16d for fluid flow communication therebetween, and together with the bores 16c and 16d of the end caps 16a and 16b forms a fluid flow passage connecting the inlet and outlet means in the end caps 16a and 16b of the body member 10.
A valve means is positioned within the flexible conduit 22 and is adapted to open and permit the intermittent, larger, flushing flow of fluid to pass through the flexible conduit 22 when the conduit 22 is squeezed, and to close when the squeezing action on the conduit 22 is terminated. Preferably, the valve means comprises a substantially cylindrical plug member 23 (FIG. 3) positioned coaxially within the flexible conduit 22. The plug member 23 has a raised band 23a thereabout intermediate its ends, with the band 23a having a sufficient diameter that its exposed surface forms a substantially flow tight seal with the interior wall of the flexible conduit 22, so that when the flexible conduit is not being squeezed, fluid is substantially completely prevented from flowing around the plug between the raised band 23a and the interior wall of flexible conduit 22. Preferably, the raised band 23a is located around the plug member 23 substantially equidistant from the ends of the plug member 23. In any case, the cylindrical extension 16f extends to a point adjacent to but slightly spaced from the raised band 23a. The portion of the plug member 23 on the upstream side of the raised band 23a, i.e., the portion of the plug member 23 which extends from the raised band to the end cap 16a, is of a reduced diameter and thus an open flow space 24 is formed between the flexible conduit 22 and that particular portion of the plug member 23. The portion of the plug member 23 on the downstream side of the raised band 23a has a sufficiently reduced diameter whereby such portion fits coaxially within the cylindrical hollow extension 16f with an open flow space 24a being formed between the interior surface of the cylindrical extension 16f and the downstream portion of the plug member 23.
When the flexible conduit 22 is subjected to a squeezing action in the vicinity of the raised band 23a, the seal between the raised band 23a and the interior wall of the flexible conduit 22 is broken, due to deformation of the flexible conduit 22 which creates flow channels extending across the raised band 23a. Fluid can then flow around the plug member 23 and through the flexible conduit 22. Upon termination of the squeezing action on the flexible conduit 22, the seal between the raised band 23a and the interior wall of the flexible conduit 22 is automatically re-established, thereby terminating the flow of fluid around the plug member 23. Advantageously, the base portion of the body member 16 has concave depressions 16g (FIG. 2) in the side thereof facing the flexible conduit 22 and the two sides thereof extending from the flexible conduit, respectively. The concave depressions form finger guides on each side of the control member 10 which aid in positioning one's fingers for squeezing the flexible conduit 22.
A second passage is provided in the control member 10 for by-passing the valve means in the flexible conduit 22 and connecting the inlet and outlet means of body member 16. Such a by-pass passage could be routed through the body member 16 from the inlet means in end cap 16a to the outlet means in end cap 16b. Preferably, however, the second passage is combined in the valve means itself as shown in FIGS. 3 and 6. In the preferred mode, the plug member 23 is positioned concentrically in the flexible conduit 22 and is provided with a bore 25 extending longitudinally through the plug member 23 which by-passes the valve means in the flexible conduit 22.
Flow restriction means is provided in the second passage for limiting the amount of fluid passing through the second passage to a desired relatively small rate. As illustrated in FIG. 3, the flow restriction is advantageously provided by forming at least a portion of the bore 25 into a capillary section having a very small diameter in the order of several hundredths of a millimeter. As shown in FIG. 3, the bore 25 forms the capillary which extends the length of the plug member 23. The capillary is shown in FIG. 3 in greatly exaggerated proportions for purposes of clarity, since the capillary in reality is so small in diameter as to be practically invisible without the use of some type magnification. By incorporating capillary sections 25a of different diameters and lengths, a broad series of apparatus can be readily produced from which individually sized units can be chosen which will deliver the desired amount of fluid under the given upstream pressure which is to be utilized in the particular application.
In an alternate embodiment of the plug member 23 shown in FIG. 6, the flow restriction is provided by positioning a resistance element 26 in an oversize bore 25 of the plug member 23. The resistance element 26 comprises a marine-bore capillary tube, with the diameter of the bore in the element 26 being very small, in the order of hundredths of a millimeter. The bore in the element 26 of FIG. 6 is shown in greatly exaggerated proportions for purposes of illustration. To aid in positioning the marine-bore resistance element 26 in the bore 25 of plug member 23, the bore 25 has a downstream section having a reduced diameter as shown in FIG. 6. The capillary tube 26 is then forced into bore 24 from the upstream end thereof until it abuts the edges of the reduced diameter section of bore 25. The outside diameter of the resistance element 26 is sufficient so that a tight, non-leaking seal is made between the external surface of the element 26 and the bore 25.
Preferably, the second passage extending through the plug member 23, i.e., the bore 25 is coaxial with the longitudinal axis of the plug member 23. Also, the upstream and downstream ends of the plug member 23 are advantageously tapered as shown in FIGS. 3 and 4. The plug member 23 preferably fits securely within beveled ends of the flow passage which is formed between the end caps 16a and 16b. The tapered ends of the plug member 23 are received in beveled receptacles in the hub 16f and at the inside base of the cylindrical extension 16f. The beveled receptacles are formed symmetrically about the axis of the first passage, and, thus, when the tapered end of the plug member 23 is received therein, the bore 24 of plug members 23 is maintained in axial alignment with the bores 16c and 16d in end cap 16a and 16b, respectively. As shown in FIGS. 4 and 5, the beveled receptacle in the base of the cylindrical extension 16f has three undercut slots 16h in the beveled surface and positioned equidistantly therearound. This leaves three equally spaced beveled ribs 16j upon which the tapered end of the plug member 23 seats. Fluid flow communication is established from the flow passage around the plug member 23 to the passage 16d in end cap 16b via way of the undercut slots 16h. The beveled receptacle in hub 16e at the other end of the plug member 23 is of the same basic construction as the beveled receptacle shown in FIGS. 4 and 5, with the upstream, tapered end of the plug member 23 adapted to seat on the beveled ribs, so that fluid flow communication is established from the passage 16c in the end cap 16a to the flow space 24 around the plug member 23 via way of the undercut slots 16h.
In use, the flow device of this invention is efficient, reliable, and easy to manipulate. Prior to the insertion of the catheter into an artery or vein of the patient, the flow device of this invention is connected between the catheter and a source of medical fluid. The medical fluid can be contained in a pressurized vessel, or a container which is elevated sufficiently above the patient so as to provide for the working upstream pressure necessary for proper flow of fluid through the bore 25 of the device.
All air bubbles are eliminated from the catheter system by squeezing the flexible tube 22, thereby flushing the system with a relatively large flow of fluid which flows past the valve plug 23. When all air bubbles have been eliminated, the squeezing action on tube 22 is terminated and the relative large flow of fluid stops, with only the limited, small flow of fluid through the second passage or bore 25 continuing. The catheter is then inserted into the patient's body, with the small flow of fluid passing through the catheter into the vein or artery of the patient. This continuous flow of fluid through the catheter reduces the occurrence of blood clotting or other occlusions occurring in the end of the catheter positioned within the patient's body.
The fitting 21 on the end cap 16b of the flow control device is, of course, connected to whatever indicating or recording means is desired, or to a pressure transducer for oscilloscopic observations. To assure quality of the information obtained from the catheter system, the system is manually flushed from time to time with a relatively rapid flushing flow of fluid by simply squeezing the flexible tube 22 of the flow control apparatus to permit fluid to flow around the valve plug 23. When the squeezing action is terminated the relatively rapid flow of fluid through the catheter stops, and the smaller flow of fluid from the bore 24 continues in its normal course. The periodic flushing of the catheter systems is accomplished quickly and easily, using only one hand of the person handling the apparatus.
The device of this invention can also be advantageously used in combination with a stopcock downstream of the unit 10 to obtain blood samples from the patient or to infuse a desired amount of medication or blood samples to the patient without requiring a second catheterization, cannulation or hypodermic injection of the patient.
It has been found that the cylindrical extension 16f positioned around the portion of the plug member 23 downstream from the raised band 23a on the plug member 23 has a significant beneficial effect on the wave forms and other clinical data produced by monitoring apparatus attached to the device by way of fitting 21. Restraining the movement of the plug member 23 at both of its ends also has a beneficial effect on the wave forms and other cinical data produced by the monitoring apparatus.
Although the apparatus has been shown and described in connection with a catheter system wherein the catheter is placed in the arm of a patient, it is to be understood that the catheter may be entered into various veins or arteries of the body as the general medical situation requires. It is further to be understood that the present disclosure, including the detailed description of a preferred embodiment of the invention, is made by way of example and that various other embodiments are possible without departing from the subject matter coming within the scope of the following claims, which subject matter is regarded as the invention.
|Cited Patent
|Filing date
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|Jan 10, 1964
|Jan 17, 1967
|Bergman Richard I
|Apparatus for administering parenteral liquids
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|Jul 11, 1972
|Voys Inc Le
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|Walker Ralph S
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|Peter von Berg Extrakorporale Systems-Medizintechnik GmbH
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|May 10, 1988
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|Aug 15, 1989
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|Jun 19, 1990
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|Apr 24, 2001
|Mayo Foundation For Medical Education And Research
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|Oct 8, 2002
|Sherwood Services, Ag
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|Aug 22, 2001
|Oct 12, 2004
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|Sep 2, 2004
|Dec 18, 2007
|Breg, Inc.
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|Nov 3, 2009
|Medrad, Inc.
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|Sep 21, 2009
|Aug 28, 2012
|Medrad, Inc.
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|Aug 27, 2012
|Dec 30, 2014
|Bayer Medical Care Inc.
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|Dec 13, 2010
|Apr 14, 2015
|Cook Medical Technologies Llc
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|Dec 22, 2014
|Dec 27, 2016
|Bayer Healthcare Llc
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|Nov 19, 2003
|Sep 2, 2004
|Gmp/Cardiac Care, Inc.
|Hemostasis valve and method of using a hemostasis valve
|Apr 21, 2003
|Aug 17, 2006
|Neuron Therapeutic, Inc.
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|Oct 31, 2007
|Mar 6, 2008
|Medrad, Inc.
|Flow Based Pressure Isolation and Fluid Delivery System Including Flow Based Pressure Isolation and Flow Initiating Mechanism
|Dec 22, 2006
|Jun 26, 2008
|Medrad, Inc.
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|Dec 13, 2010
|Dec 22, 2011
|Cook Medical Technologies Llc
|Low-profile one-way valve
|Jan 16, 1997
|Jul 24, 1997
|Valleylab Inc
|Rinsing device for surgical use
|Apr 3, 1997
|Oct 15, 1997
|Nissho Corporation
|Three-way stopcock and flow rate control device in use thereof
|Apr 3, 1997
|Apr 15, 1998
|Nissho Corporation
|Three-way stopcock and flow rate control device in use thereof
|Apr 24, 1987
|Nov 5, 1987
|Centre National De La Recherche Scientifique (Cnrs
|Rechargeable implantable device for dosed and repeated self-injection of medicament
|Oct 17, 1997
|Jun 11, 1998
|Mayo Foundation
|Hemostasis valve, system and assembly
|Dec 19, 2012
|Jul 11, 2013
|Surgical Apps Pty Ltd
|A manually operated medical pump
|U.S. Classification
|604/30, 604/36, 604/93.01
|International Classification
|Cooperative Classification
|European Classification
|Feb 4, 1986
|Maintenance fee reminder mailed
|Feb 27, 1986
|Fee payment
Year of fee payment: 4
|Feb 27, 1986
|Surcharge for late payment
|Feb 6, 1990
|Maintenance fee reminder mailed
|Feb 12, 1990
|Surcharge for late payment
|Feb 12, 1990
|Fee payment
Year of fee payment: 8
|Feb 8, 1994
|Maintenance fee reminder mailed
|Jul 3, 1994
|Lapse for failure to pay maintenance fees
|Sep 13, 1994
|Expired due to failure to pay maintenance fee
Effective date: 19940706


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To be upset to hear DS referred as "hyper boy" by his cousin(44 Posts)
Context: ILs on Skype with DBiL and DNephews. DD1 and DD2 were here and DNephew says "Where is hyper-boy?", clearly referring to DS, 4. My lovely nephew is 5 and he's clearly using words from his parents. I am so upset.
For the record, DS is very active and excitable, but nothing out of the ordinary. No problems at all at school.
I just find it horrible that his own uncle would use this label when referring to him in front of his children. For the record, DH is not a fan of his DB and I was trying to build bridges for the sake of DMil and the children.
Hyper-boy sounds like an apprentice superhero.
I like it.
I wouldn't like it, OP.
My MIL used to call DS1 hyperactive (well, she pronounces it hypOactive --cos she's a bit thick--) and tell me it was all the sugar he eats... 5 minutes after she'd given him a bag of skittles
Hmm. I quite often refer to OH's nephew as 'Gollum' around my two. Might need to stop that. Although given I often refer to my own two children as 'Fatboy' and 'Imhotep' affectionately, I might be able to wriggle out of it...
The parents may not have named him such, or may have done as an affectionate term (my youngest is astro-boy - we named him that, superhuman and lively and lovely) or just a nick name with not offence intended.
YANBU though. I once described a friend's son as a bit of a 'far side child' - in a conversation between myself and DH. It was a throw away comment between two adults, I didn't know small ears were listening. I learned my lesson HARD, and couldn't wiggle out of it.
It could have been a one off comment from the parents. Children do pick up very quickly if they think something's funny.
I remember reading a book with dd2 when she was about 4yo which referred to a character in it once as "Jumping Jolly Jo".
Next day she referred to a child in her class as "Jumping Jolly Jo"... she thought it was funny and couldn't see why I told her she shouldn't use it-until I made an equivalent one for her name.
My son made up his own id for online gaming when he was about 5 - HyperJake
I think it is cool, as would other kids. I don't think it's offensive. If you feel it is being used offensively.... that's another thing.... but to me it sound like there is no harm in it at all.
He is not hyperactive though. He can concentrate for very long periods of time and has absolutely no problems at school. We can go to restaurants for longish meals and he behaves etc etc.
He is just a regular 4 year old boy IMO.
So, MIL must have told DBil and he sent an email to apologise to DH, saying that we should not take offence and they all regularly call each other this.
I don't buy it but whatever. I think we'll move on.
I am indeed very sensitive when it comes to my children. Although I don't mind if family and friends discipline them when needed, clear favoritism and labelling is not on.
I agree it's rude and a put down. Next time just say 'how rude, who calls him that?'
OP You sound over-sensitive.
Hyper boy is a perfectly innocent way of describing a boy who is as you described your son. I don't think it's the least derogatory.
It's also possible that your nephew gets called hyper-boy and in turn has called your son that. It's the kind of things children do.
You really need to relax about this kind of thing.
I agree, btw, with the posters that have said that the nickname itself is not necessarily offensive but it is horrible to feel your child being is being discussed negatively behind your back. Especially in front of other children.
But but but...
Unless you know this - and you don't for sure - just move on. By all means talk to your in laws about how you feel about their approach to the children, or ask the parents straight out whether it came from them and why. Stick to facts and how it makes you feel, not speculation.
If you just get upset but do nothing it will simmer.
I think there's a big difference between an affectionate family nickname used openly and the parents calling your son a fairly disparaging name to each other behind your back. I don't think "hyper boy" is affectionate or kind. I'd be p'ed off too.
You seem a bit oversensitive about your ds. Has someone criticised his behaviour in the past?
"a child like that" Nice
You've said yourself that your son is very active and excitable.
Hyper-boy is very apt I would have thought
Are you checking carefully - by other peoples' responses - that your son isn't annoying other people?
My heart goes out to you having a child like that because they CAN be very annoying to other people
On second thoughts, it is worth bringing it up with BiL or asking DH to do it, because it won't be nice for DS to hear himself referred to as this in future.
Edma, you are right to be upset over it. It is not nice and I don't think it is a joke.
But if he is hyperactive, then others will notice it and make comments. It doesn't really matter as it is part of his nature. It is not nice of them to single that out, but the best thing is to just ignore it.
It's a good job you aren't related to me, OP. I love all my nieces and nephews to bits, alongside my DSs and "soft lad", "soft girl" and "bloody bugger" are all part of my repetoire of endearments
In fact, having read all your posts it sounds as though neither you or your dh like them much at all so I expect any nickname they gave him would be offensive in your eyes.
Sometimes it's hard not to be offended by people who you don't like, if that makes sense.
How do your children get on with their cousins? Do they like them?
And finally, it seems to me that your real problem is your fil ignoring your son and favouring your daughter, rather than a bit of good-natured joshing from your nephews .
Is it not a joke? My kids named our last cat after their youngest cousin, because he (the cat) was a bit of a nutter and kept stealing food off their plates, which was exactly what their cousin used to do when he was a toddler.
It was a joke, and everyone thought it was funny.
There is no way they would have teased someone they weren't fond of in such a way.
It's quite endearing.
Apart from anything, it may be something they have said just once and he has turned it into a nickname, rather than something routinely spoken about when your son's name comes up. I wouldn't worry if it were me, but if you feel strongly about it then maybe ask them not to call him that because it upsets you.
And if it was affectionate, surely they would have called him this to his/our face. Not referred to him like this behind our back.
I am probably too wet/soft, and overreacting, but it just puts me off. I have to make loads of efforts as DH doesn't really like his brother (although he likes his SIL and the DNs) and I have pushed for us to spend more time together, mostly for the children to spend time with their cousins.
They are supposed to come and spend 2 weeks with us this summer. DH wasn't keen to start with. So that's not helping.
Thinking about it, I still want the children to spend time together. I just will need to make sure this doesn't happen again.
Message withdrawn at poster's request.
If it was meant affectionately it would be fine, but you know it's meant disparagingly and that's not on.
In my experience most 4 year olds are loud and energetic (my 3 girls all were), it's not fair to pigeonhole them.
I can understand OP being upset as `hyper` is not a term that is generally used admiratively when describing someone.
Nicknames are lovely as long as they are merely affectionate and don`t have negative connotations.
As a child my grandfather always called me `Beefy`. I was not overweight at all, but have spent my entire life feeling like an ungainly lump - even in my twenties when I was a size eight I never felt good about my body.
OP`s DS is too young to understand yet, but she should have a word with her DB and tell him how she feels.
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Does It Help When I 'Like' My Company Facebook Posts?
With Facebook page post reach decreasing for many brands over the years, companies look to do anything they can to increase their reach (try posting content your audience really wants to see, rather than just what you want them to see). In hoping to increase the success of their company posts we often see employees Liking everything they share. While employees may think they're helping out, they really aren't. Here's why.
How To Get The Most From Cinemagraphs On Facebook
Cinemagraphs are awesomely engaging content. They draw the attention of your viewer in a way that static images and standard video can't.
While the process of creating them can be a challenge without the right software and know-how, creating them isn't the only step that takes planning. Promoting your cinemagraphs on social needs thought too. Here's how to get the most from your cinemagraphs on Facebook.
Facebook Reactions: What Marketers Need To Know
It's official, today Facebook rolled out Reactions to all users across the globe! In addition to Liking a post, you can now respond with Love, Haha, Yay, Wow, Sad, and Angry. Facebook reactions give users even more ways to share how they feel, quickly and easily.
In addition to allowing Facebook users to share their reactions with more than just 'Like', these new changes will impact marketing too. Check out what the new Facebook Reactions mean to marketers.
The New Facebook Notify: What It Means To Marketers
Yesterday, Facebook announced the launch of Notify. The new app alerts people of timely news from the sources they care about most. Simply select the sources you want to follow and be alerted to important news right on your phones lock-screen. Swiping notifications will bring the user right to the story on Facebook.
Study: Here's What People Engage With On Facebook
Engagement on Facebook is what makes the site run. It's also what marketers strive for most. Through all the changes to the newsfeed and content distribution, engagement has continued to be the key in getting your content seen. The more people engage with it, the more people see it.
So how do you get the most engagement from your Facebook posts? Post the most engaging types of content, right? Here's what they are.
Facebook Adds Reactions: What Marketers Need To Know
Last month, Mark Zuckerberg hosted a Q&A from Facebook headquarters. During the event, he commented on many members want to be able to react to posts with more than a simple 'Like'. Zuck shared that Facebook is working on adding functionality to allow users to indicate a greater range of emotional connection with posts (most news sources incorrectly reported that Mark had said a 'Dislike' button was on the way; apparently they didn't bother to listen to his comments as he never said this). And now it's here.
Yesterday, Facebook announced that they've begun testing new Reactions. These Reactions, shown above, give users a better way to show how they really feel about a post. Now they can show the sadness a post about your poor health brings or how angry people that litter make them. They can also celebrate things they love seeing. No longer will they have to comment with, "I wish I could like this twice!" Instead, they can use the 'Wow' or 'Love' reactions.
As with all changes to Facebook, they will likely have an impact on digital marketers. Here's what you need to know.


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ReDiscover helps people who are struggling with challenges of mental illness to find ways to achieve personal well being. We work with you to enhance the quality of daily life and take needed steps to meet individual life goals.
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Giant Lizards shall soon rule the Earth - February 8th 2010
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The Baseballs, David Vanian and the Phantom Chords, Benders, The Brains, Deadbolt and more.
The strange mammalian hallucination you call 'love' is in the air, and as it is an intergalactic standard of protocol to honour any celebration of fornication, I gave my bit to make the blood-pump shudder.
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Read an Excerpt
By Gerald Charles Dickens
My great-great-grandfather wrote The Life of Our Lord for a very special reason he wrote it for his family. He wanted his children to learn about the life and teachings of Jesus Christ in as plain and simple a way as possible, and he decided the best way to achieve that was to write it himself and give it to his family as a gift.
Charles Dickens was extremely protective of The Life of Our Lord. He was well aware that anything from his pen would be snapped up, published, distributed, and then become part of the Dickens legend; he was determined that this one work would receive no such treatment. When Charles Dickens said that The Life of Our Lord was purely for his family, he meant it. Georgina Hogarth, Charles's sister-in-law, wrote this about his refusal to publish The Life of Our Lord:
I must now tell you about the beautiful little New Testament, which he wrote for his children. I am sorry to say it is never to be published...He would never have it printed, and I used to read it to the little boys in manuscript before they were old enough to read writing themselves...I asked Charles if he did not think it would be well to have it printed, at all events for private circulation, if he would not publish it. He said he would look over the manuscript and take a week or two to consider. At the end of the time he gave it back to me and said he had decided never to publish it, or even to have it privately printed. He said I might make a copy of it for Peggy (Mrs. Dickens) or any one of his children, but for no one else, and he also begged that we would never even hand themanuscript, or a copy of it, to anyone to take out of the house.
The Dickens family felt that in return for such a wonderful gift, they must honor their father's wishes. The clan closed ranks and protected their secret with great zeal.
On Dickens's death, in 1870, the manuscript passed, along with all of his private papers, to Georgina Hogarth and, from her, to my great-grandfather, Henry Fielding Dickens. His wife, Marie (or Mumsey, as she was known in the family), carefully hid it under her mattress and my father tells me that marks from her bedsprings are clearly visible!
At the time, Henry, a well-respected lawyer, was somewhat torn because he was a great protector of his father's legacy Charles's wishes must be honored and there was no question of publishing The Life of Our Lord. However, Henry was also justly proud of his father's works, and I believe that he wanted this short volume to be more widely read. He put his legal mind to the problem and came up with a solution. In his will, Henry wrote:
I give and bequeath to my wife the original manuscript of my father's "Life of Our Lord" which was bequeathed to my aunt Georgina Hogarth in my father's will, and given by her to me to hold, on the following trusts:
Being his son I have felt constrained to act upon my father's expressed desire that it should not be published, but I do not think it right that I should bind my children by any such view, especially as I can find no specific injunction against such publication.
I therefore direct that my wife and children should consider this question quite unfettered by any view of mine, and if by majority they decide that the manuscript should not be published, I direct my wife to deposit it with the trustees of the British Museum upon the usual terms, but if they decide by a majority that it should be published, then I direct my wife to sell the same in trust, to divide the net proceeds of such sale among my wife and all my children in equal shares.
Upon Henry's death in 1933, the family thought long and hard over the question of The Life of Our Lord and decided that the time was now right to publish it. Thus, in 1934, the last published work of Charles Dickens became available to a wider audience, one hundred years after his very first piece, "A Dinner at Poplar Walk," the first of the Sketches by Boz, was published.
The Life of Our Lord tells us so much about Charles Dickens. It outlines his faith, which was simple and deeply held, but, for me, above all else it tells of his relationship with his family my family. When I read the first line of The Life of Our Lord, "My Dear Children, I am very anxious that you should know something about the History of Jesus Christ," I picture the scene in the Dickenses' nursery vividly: Charley, age twelve; Mamie, eleven; Katie, ten; and Walter, eight; all listening intently as their father explains the miracles of Christ. I envision Francis, five; Alfred, four; and Sydney, two; playing happily as their father reads, changing the narrative now and then to keep their interest. "You never saw a locust, because they belong to that country near Jerusalem, which is a great way off. So do camels, but I think you have seen a camel. At all events, they are brought over here, sometimes; and if you would like to see one, I will show you one."
And then, in the corner is a baby, not even a year old: Henry Fielding Dickens. My great-grandfather hearing, but not listening to, the voice of Dickens.
Now we have come full circle. I have three children: Georgia, eight; Jasmine, six; and Cameron, seven months. My children are almost of the same age as Walter, Francis, and Henry. My daughters are learning about Jesus Christ, and they are as fascinated by the miracles and parables as were their counterparts exactly one hundred and fifty years ago. It is time for me to read to them, "My Dear Children, I am very anxious that you should know something about the History of Jesus Christ..." And I invite you to become part of this wonderful family. Read The Life of Our Lord not as a Dickens novel that is the last thing my great-great-grandfather would have wanted. Read it as an honorary family member and draw from it the rich meaning that Charles Dickens intended when he first presented this gift to us.
Burwash, East Sussex, England
Summer 1999
Copyright © 1999 by Gerald Charles Dickens
Chapter the First.
My Dear Children,
I am very anxious that you should know something about the History of Jesus Christ. For everybody ought to know about Him. No one ever lived who was so good, so kind, so gentle, and so sorry for all people who did wrong, or were in any way ill or miserable, as He was. And as He is now in Heaven, where we hope to go, and all to meet each other after we are dead, and there be happy always together, you never can think what a good place Heaven is, without knowing who He was and what He did.
He was born, a long long time ago nearly two thousand years ago at a place called Bethlehem. His father and mother lived in a city called Nazareth, but they were forced by business to travel to Bethlehem. His father's name was Joseph, and His mother's name was Mary. And the town being very full of people, also brought there by business, there was no room for Joseph and Mary in the Inn or in any house; so they went into a stable to lodge, and in this stable Jesus Christ was born. There was no cradle or anything of that kind there, so Mary laid her pretty little boy in what is called the manger, which is the place the horses eat out of. And there He fell asleep.
While He was asleep, some shepherds who were watching sheep in the fields, saw an Angel from God, all light and beautiful, come moving over the grass towards them. At first they were afraid and fell down and hid their faces. But it said, "There is a child born to-day in the city of Bethlehem near here, who will grow up to be so good that God will love Him as His own Son; and He will teach men to love one another, and not to quarrel and hurt one another; and His name will be Jesus Christ; and people will put that name in their prayers, because they will know God loves it, and will know that they should love it too." And then the Angel told the shepherds to go to that stable, and look at that little child in the manger. Which they did; and they kneeled down by it in its sleep, and said, "God bless this child!"
Now the great place of all that country was Jerusalem just as London is the great place in England and at Jerusalem the King lived, whose name was King Herod. Some wise men came one day, from a country a long way off in the East, and said to the King, "We have seen a star in the sky, which teaches us to know that a child is born in Bethlehem, who will live to be a man whom all people will love." When King Herod heard this, he was jealous, for he was a wicked man. But he pretended not to be, and said to the wise men, "Whereabouts is this child?" And the wise men said: "We don't know. But we think the star will show us; for the star has been moving on before us, all the way here, and is now standing still in the sky." Then Herod asked them to see if the star would show them where the child lived, and ordered them, if they found the child, to come back to him. So they went out, and the star went on, over their heads a little way before them, until it stopped over the house where the child was. This was very wonderful, but God ordered it to be so.
When the star stopped, the wise men went in, and saw the child with Mary His mother. They loved Him very much, and gave Him some presents. Then they went away. But they did not go back to King Herod; for they thought he was jealous, though he had not said so. So they went away, by night, back into their own country. And an Angel came, and told Joseph and Mary to take the child into a country called Egypt, or Herod would kill Him. So they escaped, too, in the night the father, the mother, and the child and arrived there, safely.
But when this cruel Herod found that the wise men did not come back to him, and that he could not, therefore, find out where this child, Jesus Christ, lived, he called his soldiers and captains to him, and told them to go and kill all the children in his dominions that were not more than two years old. The wicked men did so. The mothers of the children ran up and down the streets with them in their arms, trying to save them, and hide them in caves and cellars, but it was of no use. The soldiers with their swords killed all the children they could find. This dreadful murder was called the Murder of the Innocents, because the little children were so innocent.
King Herod hoped that Jesus Christ was one of them. But He was not, as you know, for He had escaped safely into Egypt. And He lived there, with His father and mother, until bad King Herod died.
Copyright © 1999 by Gerald Charles Dickens
Chapter the Second.
When King Herod was dead, an angel came to Joseph again, and said he might now go to Jerusalem, and not be afraid for the child's sake. So Joseph and Mary, and her Son Jesus Christ (who are commonly called the Holy Family) travelled towards Jerusalem; but, hearing on the way that King Herod's son was the new King, and fearing that he, too, might want to hurt the child, they turned out of the way, and went to live in Nazareth. They lived there until Jesus Christ was twelve years old.
Then Joseph and Mary went to Jerusalem to attend a religious feast which used to be held in those days, in the Temple of Jerusalem, which was a great church or cathedral; and they took Jesus Christ with them. And when the feast was over, they travelled away from Jerusalem, back towards their own home in Nazareth, with a great many of their friends and neighbours. For people used, then, to travel a great many together, for fear of robbers; the roads not being so safe and well guarded as they are now, and travelling being much more difficult altogether, than it now is.
They travelled on for a whole day, and never knew that Jesus Christ was not with them; for the company being so large, they thought He was somewhere among the people, though they did not see Him. But finding that He was not there, and fearing that He was lost, they turned back to Jerusalem in great anxiety to look for Him. They found Him, sitting in the temple, talking about the goodness of God, and how we should all pray to Him, with some learned men who were called doctors. They were not what you understand by the word "doctors" now; they did not attend sick people; they were scholars and clever men. And Jesus Christ showed such knowledge in what He said to them, and in the questions He asked them, that they were all astonished.
He went, with Joseph and Mary, home to Nazareth, when they had found Him, and lived there until He was thirty or thirty-five years old.
At that time there was a very good man indeed, named John, who was the son of a woman named Elizabeth the cousin of Mary. And people being wicked, and violent, and killing each other, and not minding their duty towards God, John (to teach them better) went about the country, preaching to them, and entreating them to be better men and women. And because he loved them more than himself, and didn't mind himself when he was doing them good, he was poorly dressed in the skin of a camel, and ate little but some insects called locusts, which he found as he travelled, and wild honey, which the bees left in the hollow trees. You never saw a locust, because they belong to that country near Jerusalem, which is a great way off. So do camels, but I think you have seen a camel. At all events, they are brought over here, sometimes; and if you would like to see one, I will show you one.
There was a river, not very far from Jerusalem, called the River Jordan; and in this water John baptized those people who would come to him, and promise to be better. A great many people went to him in crowds. Jesus Christ went too. But when John saw, John said, "Why should I baptize you, who are so much better than I!" Jesus Christ made answer, "Suffer it to be so now." So John baptized Him. And when He was baptized, the sky opened, and a beautiful bird like a dove came flying down, and the voice of God, speaking up in Heaven, was heard to say, "This is my beloved Son, in whom I am well pleased!"
Jesus Christ then went into a wild and lonely country called the wilderness, and stayed there forty days and forty nights, praying that He might be of use to men and women, and teach them to be better, so that after their deaths, they might be happy in Heaven.
When He came out of the wilderness, He began to cure sick people by only laying His hand upon them; for God had given Him power to heal the sick, and to give sight to the blind, and to do many wonderful and solemn things of which I shall tell you more bye and bye, and which are called the Miracles of Christ. I wish you would remember that word, because I shall use it again, and I should like you to know that it means something which is very wonderful and which could not be done without God's leave and assistance.
The first miracle which Jesus Christ did, was at a place called Cana, where He went to a marriage-feast with Mary His mother. There was no wine; and Mary told Him so. There were only six stone water-pots filled with water. But Jesus turned this water into wine, by only lifting up His hand; and all who were there drank of it.
For God had given Jesus Christ the power to do such wonders; and He did them, that people might know He was not a common man, and might believe what He taught them, and also believe that God had sent Him. And many people, hearing this, and hearing that He cured the sick, did begin to believe in Him; and great crowds followed Him in the streets and on the roads, wherever He went.
Copyright © 1999 by Gerald Charles Dickens


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For the follow-up to Moment of Forever, his first set of new original songs in years, Kris Kristofferson decided to record a set of stripped-down new versions of his classic songs. This project, released on Atlantic Records and entitled The Austin Sessions, was a star-studded affair, featuring harmony vocals from Jackson Browne, Steve Earle, Matraca Berg, Vince Gill, Marc Cohn, Alison Krauss, Catie Curtis, and Mark Knopfler.
"Chasin' Wild Trains" is the thirteenth studio album by Kim Carnes, released in 2004. It was Carnes' first full-length album since 1991's "Checkin' Out the Ghosts" which was released only in Japan and her first to be released both in the U.S. and internationally since 1988's "View from the House". "Chasin' Wild Trains" was originally released by the Sparky Dawg Music label in the U.S. and later re-issued internationally by Dutch label Corazong. The album did not chart, however.
Although it is no secret that Emmylou Harris is one of the modern era's most prolific guest vocalists, it's only when you see her appearances laid out one after the other that you realize just how many other performers have called upon her over the years – a gamut that runs from Linda Ronstadt to Little Feat, from Bob Dylan to Bonnie Raitt.
These first complete recordings of the string quartets of Schoenberg, Berg, Webern and Zemlinsky have won numerous international awards and been hailed as landmarks in the discography of 20th-century music. Impeccable ensemble, superbly blended timbre and pure intonation ….This set [Schoenberg, Berg, Webern] is indeed a wonderful achievement (MusicWeb International). Febrile intensity and faultless proportioning of each formal structure [Zemlinsky] (Guardian).
Excellent value box containing all of Berg's major works. The best performance is maybe Abbado's of Wozzeck. This is a live recording and sounds like it;very exciting orchestral playing that sometimes almost drowns out the voices . I dont think this is a problem as it kind of fits with opera's theme of helpless people up against forces they cant control etc. The Boulez recording of Lulu is also very good but here the lack of libretto in the package is a bit annoying as the opera has a very elaborate plot and the synopsis provided isnt really detailed enough to follow what's going on.


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Slim Xbox 360 Reball
What causes this fault
These faults are caused by the fact that every manufacturer Sony, Microsoft, etc have to use Unleaded solder during the manufacturing of their games console.
This was considered a more reliable solution for the electronics industry due to the fact that unleaded solder has a higher melting point than Leaded Solder.
The only problem is that over time, Unleaded solder goes brittle and cracks, when this occurs this is when the console displays the RED light errors.
An Example of Lead and Unleaded Solder after exhaustive heating / cooling
The solution
We can remove the Graphics processor from the main board
Replace this with a brand new Graphics processor
The benefit of this procedure is that we only use Leaded solder when re soldering the chip back onto the main board.
Leaded solder does not go brittle and crack, therefore is the ultimate fix for your console.
We use the latest state of the art Computer Controlled Dark Infrared BGA reflow stations to safely and professionally carry out this process.
The Re-ball process
1. Console is stripped down and cleaned
2. Graphics processor is removed from the main board and the main board cleaned of unleadedvsolder
3. A Brand new Graphics processor soldered to the main board using only LEADED solder.
4. Console is re assembled and serviced.
5. The console is exhaustively tested to ensure everything is working 100%
We also fully service your console and give you SIX months warranty for your peace of mind.
Title : Xbox Reball - Great Service
Comment : I have been extremely impressed with Console Wizard. They have been very professional and knowledgeable. More importantly my Xbox 360 has been fixed. The communication every step away has been excellent so I knew when my Xbox was received by Console Wizard and when it was on its way back to me. I did ask Console Wizard to ring me when its ready to be dispatched and they did. Very happy with the service I received and recommend them. Regards Colin
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Kiva Lending Team: NUORGANICS
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We like to help people to help themselves and help the planet in the process. It is no secret that big companies substitute manual work in favour of technology that overlooks environmental needs. A good example of this is Fairtrade bananas - people can grow bananas without using pesticides and make profit which in turn is invested in community, instead of the pockets of few individuals who use natural resources that belongs to everyone on this planet, to reap profit for themselves.
About us
Nuorganics is a small company devoted to organic products and ethical way of conducting business around the world. Technology has given us the chance to find where help and information is needed in order to conduct better deals for people and our planet.
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Cusco Magnetic Oil Drain Plug
Free Shipping
Inside Continental United States
Earn 65 reward points. Learn More
Will It Fit Your Vehicle?
This is not a vehicle specific partPlease read the product description and details prior to purchase. Please contact us if you need assistance.
Using a powerful 4500 Gauss Neodymium magnet, Cusco Aluminum Drain Bolt will capture metallic pollutants and microscopic particles that reside in motor oils, even those which may not be captured by oil filters. The A7075 Duralumin alloy drain plug body material is a standard in the aerospace industry, being one of the lightest and most durable, and comes integrated with an aluminum gasket ring as well.
- Part Number: 00B 001 ND02
- Color: Blue
- Manufacturer: Cusco
Vehicle Fitment
- Honda/Mazda/Mitsubishi/Suzuki
- This part does not have vehicle specific fitment


text:
Nickname: Lions of Teranga
Association formed: 1960
Previous Afcon Appearances: 13 (1965, 1968, 1986, 1990, 1992, 1994, 2000, 2002, 2004, 2006, 2008, 2012, 2015)
Best result: Runners-Up (2002)
Coach: Aliou Cisse
Leading scorers: all-time –Henri Camara (29)
Most appearances: all-time –Henri Camara (99)
FIFA ranking: 33 (1st in CAF)
Senegal only came close to winning the Afcon title in 2002, but could they playing their hearts out for their first title this year with in-form Liverpool striker, Sadio Mane?
The Senegal national football team represents Senegal in international association football and has done so since the 1960s. It made its first, and thus far only, FIFA World Cup appearance in 2002 and caused a huge upset by defeating world and European champions France 1–0 in the tournament's opening game. Senegal eventually reached the quarter-finals of the 2002 World Cup, one of only three African teams to do so (the first being Cameroon in 1990; the other being Ghana in 2010).
Sadio Mane: One of the best players presently in the Premier League, Mane brings penetration and creativity to the Lions squad. He will, however, need the support of his teammates to get the best out of him and avoid a repeat of the 2015 tournament where he was a marked man and failed to shine.
Idrissa Gueye: 'Gana' has been a revelation this season in the English top-flight, where he has set about covering every blade of grass on the pitch in every game. He certainly will bring that all-action style into the Teranga Lions team and he should be a driving force from the engine room.
Kalidou Koulibaly: The highly sought after 25-year-old defender only recently made his debut for the Senegal national team, but has gone on to make 12 appearances in that time. He will be keen to showcase those polished defensive skills that has made Europe's top clubs queue for his signature.
Senegal finished with a perfect record in Group K, qualifying with all maximum points of 18, scoring 13 and conceding just two as they overcame the threats posed by Burundi, Namibia and Niger Republic.
Goalkeepers: Khadim N'Diaye (Horoya AC, Guinea), Abdoulaye Diallo (Çaykur Rizespor, Turkey), Pape Seydou N'Diaye (ASC Niarry Tally).
Defenders: Lamine Gassama (Alanyaspor, Turkey), Cheikh M'Bengue (Saint-Etienne, France), Kara Mbodj (Anderlecht, Belgium), Zargo Toure (Lorient, France), Kalidou Koulibaly (Napoli, Italy), Saliou Ciss (Valenciennes, France)
Midfielders: Idrissa Gana Gueye (Everton, England), Cheikhou Kouyate (West Ham, England), Cheikh N'Doye (Angers, France), Papakouli Diop (Espanyol, Spain), Henri Saivet (Saint Etienne, France), Papa Alioune Ndiaye (Osmanlıspor, Turkey), Mohamed Diame (Newcastle, England)
Forwards: Sadio Mane (Liverpool England), Keita Balde Diao (Lazio, Italy), Moussa Konate (FC Sion, Switzerland), Famara Diedhiou (Angers, France), Mame Biram Diouf (Stoke, England), Ismaila Sarr (Metz, France), Moussa Sow (Fenerbahce, Turkey)


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#AceWorldNews – Jan.12: This is not Oliver Twist this is real people starving who need to be fed, NOW
Though as this exclusive confirms that a UN humanitarian convoy reached the besieged town of Madaya, RT spoke to its residents, who said that though they had managed to escape the blockade, the rebels are still controlling most of the town's resources and sold them food at "inflated prices."
On Monday, the small town on the Lebanese border in southern Syria received 44 trucks which contained food, various medicines and blankets as part of an agreement between the UN and the Syrian government.
"We're happy we managed to escape the blockade, but my parents are stuck here. We don't have money or friends – we only hope the government helps," a local woman told RT's Murad Gazdiev. The RT team are the only foreign journalists who have so far managed to make it to Madaya.
One of the problems the besieged town faced was the despotism of the rebels who took over the city. They repeatedly confiscated humanitarian aid and sold it off at higher prices, local residents told Gazdiev.
"The prices rose so high… militants sold us humanitarian aid at inflated prices. A kilogram of rice cost $250," a local resident told RT.
"Of course, the blockade was in the interest of traders, not the government. The government sent us aid, but we never got it, because it was sold off," another resident said.
People in Madaya are in desperate need of medical help.
"I am ill… but there were no medical facilities here at all," one woman said. "I can hardly stand on my feet."
READ MORE: First aid convoys enter besieged Syrian town of Madaya
In the meantime, UN ambassadors asked the Syrian government to allow an airlift of 400 people from the town.
Ace News Services (@AceNewsServices)
12/01/2016, 05:37
Evacuation call at starving Syrian town: Some 400 people in the besieged rebel-held Syrian town… bbc.in/1W1I9Vf #AceNewsReport
"They need medical evacuation on an urgent basis tonight and they want permission from the government of Syria to lift those people out," the New Zealand ambassador, Gerard van Bohemen, told reporters.
Source: RT International @RT_com
News & Views welcome always published as long as NO bad language or is not related to subject matter.
Thanks for following as always appreciate every like, mention , reblog or #tweet also our newspaper is added with all our posts daily:
Breaking – Main News – Finance – World – Social – Food – History – Britain – Scotland – Friends – Authors – #Tweet – PC-Help – Newsroom – Chat – Shop & Share – Disability — more to come.
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text: BEACHWOOD, Ohio, Nov. 7, 2016 /PRNewswire/ -- OMNOVA Solutions Inc. (NYSE: OMN) today announced that it is moving forward with its CEO succession process, and Kevin M. McMullen is stepping down as Chairman, Chief Executive Officer and President, and as a member of the Board of Directors, effective December 1, 2016, to pursue other interests. In over 16 years leading the Company, McMullen succeeded in repositioning OMNOVA as a leader in specialty chemicals and engineered surfaces including aggressive portfolio actions highlighted by the acquisition of Eliokem International. OMNOVA has experienced significant positive momentum with adjusted earnings per share up nearly 60% year-to-date through the third quarter, following 29% growth for the full year 2015. He is enthused about his future and proud of the Company's progress under his leadership. McMullen will be succeeded by Anne P. Noonan as OMNOVA's President and Chief Executive Officer, effective December 1, 2016. Ms. Noonan will also be appointed to the Company's Board of Directors. In connection with this leadership transition, the Board of Directors has determined to separate the Chairman and Chief Executive Officer roles, electing William R. Seelbach as the Company's independent, non-executive Chairman, also effective December 1, 2016. Michael J. Merriman, the Presiding Director of the OMNOVA Board of Directors, commented, "Kevin is a high-integrity leader with strong strategic and business acumen. We are thankful for Kevin's many years of leadership and his dedicated service to OMNOVA, both as Chief Executive Officer and as Chairman. He has consistently been aggressive in assessing the market and competitive environment, and taking the necessary actions to make the Company better. He leaves an organization with a well-designed growth strategy and strong leadership team in place. On behalf of the entire OMNOVA Board and the Company, I want to express our gratitude for a job well done and wish Kevin only the best. He will be missed." McMullen's initiatives over the years ensured OMNOVA's prominence and profitability despite many market-based challenges. A predominately U.S.-based company when he took charge, McMullen led OMNOVA's transformation into a global enterprise. Today, OMNOVA products are sold in over 90 countries around the world, supported by manufacturing and technology centers on three continents. He drove initiatives to dramatically expand the breadth of OMNOVA's technology to significantly enhance its position as a value-added solutions provider. McMullen, 56, joined the Company in 1996 as President of its Decorative and Building Products unit. He took over as Chief Executive Officer of the Company in 2000 and became Chairman of the Board in 2001. Prior to OMNOVA, McMullen worked for GE and McKinsey & Co.


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Definition of heartless
1 archaic : spiritless
2 : lacking feeling : cruel
Examples of heartless in a Sentence
a heartless boss who would fire people for missing work, even if they were sick as a dog
his heartless whipping of runaway slaves virtually to the point of death shocked even other slave owners
Recent Examples of heartless from the Web
Maybe someone has made a kids' movie with a principal who isn't buffoonish or heartless, but here the stereotypes are embraced with a vengeance.
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'heartless'. Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
First Known Use of heartless
14th century
HEARTLESS Defined for English Language Learners
Definition of heartless for English Language Learners
: very cruel
HEARTLESS Defined for Kids
Learn More about heartless
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text:
Not a good morning to start with
Good morning campers, didn't have a great start this morning felt very anxious, my legs felt like lead, my words just couldn't get them out and my fingers didn't feel they were mine all thumbs. Felt quite Weak and shaky all over. Read some posts and answered some whey hey I'm feeling normal again. Love this site, changes my thinking thanks guys hope it helps you lot too. My heart goes out to one young girl thats so very scared today took me back to my childhood bless her touched my heartstrings to help I was there once. Lets all wish her strength xxx Mandy 😊
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Adults: £10 Children (7-15): £7 (not suitable for children under 7)
information on badgers
From the very edge of their natural sett, you can observe the antics of these
secretive and fascinating animals, fully illuminated from above and from a purpose-built hide. You may also see squirrels, woodpeckers,
jays, nuthatches, and pheasants. It is now possible for amateur photographers
to shoot pictures of the badgers in their natural habitat on special Photography
Evenings (£25 per person).
Places are limited, so
booking is essential - details will be displayed here in season. This
activity is unsuitable for those aged under 8 years.
+44 (0) 1398-351506


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A Study of Two Approved Drugs in the Treatment of Post-Bunionectomy Surgery Pain (0966-234)(COMPLETED)
This study has been completed.
Merck Sharp & Dohme Corp.
Information provided by (Responsible Party):
Merck Sharp & Dohme Corp.
ClinicalTrials.gov Identifier:
First received: September 22, 2004
Last updated: May 5, 2017
Last verified: May 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following bunionectomy surgery.
|Postoperative Pain
|Drug: MK0966, rofecoxib Drug: Comparator: diclofenac sodium, placebo
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Investigator
Primary Purpose: Treatment
|Official Title:
|A Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled, Parallel-Group Study of Rofecoxib and Diclofenac Sodium in the Treatment of Post-Bunionectomy Surgery Pain
Resource links provided by NLM:
Drug Information available for: Diclofenac sodium DiclofenacU.S. FDA Resources
Further study details as provided by Merck Sharp & Dohme Corp.:
Primary Outcome Measures:
- Overall analgesic effect over 8 hours
Secondary Outcome Measures:
- Time to onset of analgesic effect.
- The use of supplemental analgesia on Days 2-3.
- Peak analgesic effect on Day 1.
- Overall safety and tolerability.
- The analgesic effect on Days 2-3.
|Actual Study Start Date:
|September 1, 2003
|Study Completion Date:
|December 1, 2003
|Primary Completion Date:
|December 1, 2003 (Final data collection date for primary outcome measure)
The duration of treatment is 5 days for rofecoxib and 1 day for diclofenac sodium.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Bunion removal
Exclusion Criteria:
- Any known allergies to the study design
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00092378
Please refer to this study by its ClinicalTrials.gov identifier: NCT00092378
Sponsors and Collaborators
Merck Sharp & Dohme Corp.
|Study Director:
|Medical Monitor
|Merck Sharp & Dohme Corp.
More Information
Study Data/Documents: CSR Synopsis
Keywords provided by Merck Sharp & Dohme Corp.:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on June 23, 2017
Study Data/Documents: CSR Synopsis
|Responsible Party:
|Merck Sharp & Dohme Corp.
|ClinicalTrials.gov Identifier:
|NCT00092378 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 22, 2004
|Last Updated:
|May 5, 2017
Keywords provided by Merck Sharp & Dohme Corp.:
Additional relevant MeSH terms:
Pain, Postoperative
Neurologic Manifestations
Nervous System Diseases
Postoperative Complications
Pathologic Processes
Signs and Symptoms
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Cyclooxygenase 2 Inhibitors
ClinicalTrials.gov processed this record on June 23, 2017


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