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The UK Chief Medical Officer has noted that "infectious disease is as great a threat to national security as climate change", with more than one new threatening disease identified each year, and that "the difficulty and challenge in identifying and tracking future threats is not the acquisition of trusted physiological and genomic data, but in using these huge databases with new computer science methods for analysis."
Existing lab-based methods for testing for infectious disease can take up to four weeks to perform, and whole-genome analysis of pathogen DNA, combined with machine learning across the Electronic Health Records (EHR), could be performed near same-day, greatly improving our ability to identify and fight outbreaks of infectious disease. Here, the engineering challenge is to develop probabilistic models to explore relationships between the massively-multivariate genomic data (the "genotype") of the pathogen and the corresponding patient data from the EHR (the "phenotype"), including lab test results, blood tests, biochemistry, and patient physiology for large cohorts of patients with fully-labelled EHR data (including sequenced blood cultures of bacteria). The emphasis is on delivering the right antibiotic to the right patient, and using "novelty detection" to identify new resistance strains.
This project involves the development of novel models, including machine learning methods along with techniques from computational biostatistics, to identify genomic markers of antibiotic resistance and susceptibility within various pathogens.
David Clifton is an Associate Professor in the Department of Engineering Science of the University of Oxford. He is a Research Fellow of the Royal Academy of Engineering. His research focuses on the development of "big data" machine learning for tracking the health of complex systems. Danny Wilson is a Sir Henry Dale Fellow working on microbial genomics at the University of Oxford Nuffield Department of Medicine. He is an associate member of the Department of Statistics and a principal investigator at the Oxford Martin School Institute of Emerging Infections.
This project is part of the Modernising Medical Microbiology Project, an international consortium led by Professor Derrick Crook, professor of microbiology at the University of Oxford and director of the National Infection Service at Public Health England. The consortium is supported by a multi-million pound funding portfolio, including from the Wellcome Trust, the Medical Research Council and the Bill and Melinda Gates Foundation. We have a strong record of publishing in the top internationally recognized journals, and our research has impacted on the delivery of public health and microbiology in Britain and beyond. For more information visit www.modmedmicro.ac.uk.
The Modernising Medical Microbiology consortium provides an excellent research environment in which to develop new skills and train among world-leading scientists in their field. Based at the John Radcliffe Hospital, the University of Oxford team consists of a community of research groups led by Profs Derrick Crook, Tim Peto, Sarah Walker and Drs David Clifton, Kate Dingle, Phil Fowler, Zam Iqbal, Danny Wilson and David Wyllie. We have specialist expertise in microbiology, genomics, statistics, epidemiology and bioinformatics, and our work focuses on understanding the causes of infectious disease in populations. Training is provided by weekly supervisory meetings, weekly Modernising Medical Microbiology work-in-progress meetings, journal clubs, seminar series, and external opportunities including attending national and international conferences. The department and university run training courses, while the Department for Continuing Education and the Language Centre offer further opportunities for personal development to research students at Oxford.
Genetics & Genomics and Immunology & Infectious Disease
Project reference number: 845
|Professor Daniel J Wilson
|Experimental Medicine Division
|Oxford University, John Radcliffe Hospital
|Professor David Clifton
|Department of Engineering Science,University of Oxford
Lancet Infect Dis, 16 (11), pp. 1295-1303. Read abstract | Read more2016. Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study.
BACKGROUND: New approaches are urgently required to address increasing rates of gonorrhoea and the emergence and global spread of antibiotic-resistant Neisseria gonorrhoeae. We used whole-genome sequencing to study transmission and track resistance in N gonorrhoeae isolates. METHODS: We did whole-genome sequencing of isolates obtained from samples collected from patients attending sexual health services in Brighton, UK, between Jan 1, 2011, and March 9, 2015. We also included isolates from other UK locations, historical isolates from Brighton, and previous data from a US study. Samples from symptomatic patients and asymptomatic sexual health screening underwent nucleic acid amplification testing; positive samples and all samples from symptomatic patients were cultured for N gonorrhoeae, and resulting isolates were whole-genome sequenced. Cefixime susceptibility testing was done in selected isolates by agar incorporation, and we used sequence data to determine multi-antigen sequence types and penA genotypes. We derived a transmission nomogram to determine the plausibility of direct or indirect transmission between any two cases depending on the time between samples: estimated mutation rates, plus diversity noted within patients across anatomical sites and probable transmission pairs, were used to fit a coalescent model to determine the number of single nucleotide polymorphisms expected. FINDINGS: 1407 (98%) of 1437 Brighton isolates between Jan 1, 2011, and March 9, 2015 were successfully sequenced. We identified 1061 infections from 907 patients. 281 (26%) of these infections were indistinguishable (ie, differed by zero single nucleotide polymorphisms) from one or more previous cases, and 786 (74%) had evidence of a sampled direct or indirect Brighton source. We observed multiple related samples across geographical locations. Of 1273 infections in Brighton (including historical data), 225 (18%) were linked to another case elsewhere in the UK, and 115 (9%) to a case in the USA. Four lineages initially identified in Brighton could be linked to 70 USA sequences, including 61 from a lineage carrying the mosaic penA XXXIV allele, which is associated with reduced cefixime susceptibility. INTERPRETATION: We present a whole-genome-sequencing-based tool for genomic contact tracing of N gonorrhoeae and demonstrate local, national, and international transmission. Whole-genome sequencing can be applied across geographical boundaries to investigate gonorrhoea transmission and to track antimicrobial resistance. FUNDING: Oxford National Institute for Health Research Health Protection Research Unit and Biomedical Research Centre. Hide abstract
Proc. Natl. Acad. Sci. U.S.A., 113 (22), pp. E3101-10. Read abstract | Read more2016. Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation.
Staphylococcus aureus is a major bacterial pathogen, which causes severe blood and tissue infections that frequently emerge by autoinfection with asymptomatically carried nose and skin populations. However, recent studies report that bloodstream isolates differ systematically from those found in the nose and skin, exhibiting reduced toxicity toward leukocytes. In two patients, an attenuated toxicity bloodstream infection evolved from an asymptomatically carried high-toxicity nasal strain by loss-of-function mutations in the gene encoding the transcription factor repressor of surface proteins (rsp). Here, we report that rsp knockout mutants lead to global transcriptional and proteomic reprofiling, and they exhibit the greatest signal in a genome-wide screen for genes influencing S. aureus survival in human cells. This effect is likely to be mediated in part via SSR42, a long-noncoding RNA. We show that rsp controls SSR42 expression, is induced by hydrogen peroxide, and is required for normal cytotoxicity and hemolytic activity. Rsp inactivation in laboratory- and bacteremia-derived mutants attenuates toxin production, but up-regulates other immune subversion proteins and reduces lethality during experimental infection. Crucially, inactivation of rsp preserves bacterial dissemination, because it affects neither formation of deep abscesses in mice nor survival in human blood. Thus, we have identified a spontaneously evolving, attenuated-cytotoxicity, nonhemolytic S. aureus phenotype, controlled by a pleiotropic transcriptional regulator/noncoding RNA virulence regulatory system, capable of causing S. aureus bloodstream infections. Such a phenotype could promote deep infection with limited early clinical manifestations, raising concerns that bacterial evolution within the human body may contribute to severe infection. Hide abstract
Nat Microbiol, 1 pp. 16041. Read abstract | Read more2016. Identifying lineage effects when controlling for population structure improves power in bacterial association studies.
Bacteria pose unique challenges for genome-wide association studies because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome(1,2). Although methods developed for human studies can correct for strain structure(3,4), this risks considerable loss-of-power because genetic differences between strains often contribute substantial phenotypic variability(5). Here, we propose a new method that captures lineage-level associations even when locus-specific associations cannot be fine-mapped. We demonstrate its ability to detect genes and genetic variants underlying resistance to 17 antimicrobials in 3,144 isolates from four taxonomically diverse clonal and recombining bacteria: Mycobacterium tuberculosis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Strong selection, recombination and penetrance confer high power to recover known antimicrobial resistance mechanisms and reveal a candidate association between the outer membrane porin nmpC and cefazolin resistance in E. coli. Hence, our method pinpoints locus-specific effects where possible and boosts power by detecting lineage-level differences when fine-mapping is intractable. Hide abstract
Lancet Infect Dis, 15 (10), pp. 1193-202. Read abstract | Read more2015. Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
BACKGROUND: Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis. METHODS: Between Sept 1, 2010, and Dec 1, 2013, we sequenced a training set of 2099 Mycobacterium tuberculosis genomes. For 23 candidate genes identified from the drug-resistance scientific literature, we algorithmically characterised genetic mutations as not conferring resistance (benign), resistance determinants, or uncharacterised. We then assessed the ability of these characterisations to predict phenotypic drug-susceptibility testing for an independent validation set of 1552 genomes. We sought mutations under similar selection pressure to those characterised as resistance determinants outside candidate genes to account for residual phenotypic resistance. FINDINGS: We characterised 120 training-set mutations as resistance determining, and 772 as benign. With these mutations, we could predict 89·2% of the validation-set phenotypes with a mean 92·3% sensitivity (95% CI 90·7-93·7) and 98·4% specificity (98·1-98·7). 10·8% of validation-set phenotypes could not be predicted because uncharacterised mutations were present. With an in-silico comparison, characterised resistance determinants had higher sensitivity than the mutations from three line-probe assays (85·1% vs 81·6%). No additional resistance determinants were identified among mutations under selection pressure in non-candidate genes. INTERPRETATION: A broad catalogue of genetic mutations enable data from whole-genome sequencing to be used clinically to predict drug resistance, drug susceptibility, or to identify drug phenotypes that cannot yet be genetically predicted. This approach could be integrated into routine diagnostic workflows, phasing out phenotypic drug-susceptibility testing while reporting drug resistance early. FUNDING: Wellcome Trust, National Institute of Health Research, Medical Research Council, and the European Union. Hide abstract
Nat Commun, 6 pp. 10063. Read abstract | Read more2015. Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.
The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of bacterial diversity can be used to identify species and resistance profiles of clinical isolates. We implement this method for Staphylococcus aureus and Mycobacterium tuberculosis in a software package ('Mykrobe predictor') that takes raw sequence data as input, and generates a clinician-friendly report within 3 minutes on a laptop. For S. aureus, the error rates of our method are comparable to gold-standard phenotypic methods, with sensitivity/specificity of 99.1%/99.6% across 12 antibiotics (using an independent validation set, n=470). For M. tuberculosis, our method predicts resistance with sensitivity/specificity of 82.6%/98.5% (independent validation set, n=1,609); sensitivity is lower here, probably because of limited understanding of the underlying genetic mechanisms. We give evidence that minor alleles improve detection of extremely drug-resistant strains, and demonstrate feasibility of the use of emerging single-molecule nanopore sequencing techniques for these purposes. Hide abstract
PLoS Genet., 11 (8), pp. e1005421. Read abstract | Read more2015. New Routes to Phylogeography: A Bayesian Structured Coalescent Approximation.
Phylogeographic methods aim to infer migration trends and the history of sampled lineages from genetic data. Applications of phylogeography are broad, and in the context of pathogens include the reconstruction of transmission histories and the origin and emergence of outbreaks. Phylogeographic inference based on bottom-up population genetics models is computationally expensive, and as a result faster alternatives based on the evolution of discrete traits have become popular. In this paper, we show that inference of migration rates and root locations based on discrete trait models is extremely unreliable and sensitive to biased sampling. To address this problem, we introduce BASTA (BAyesian STructured coalescent Approximation), a new approach implemented in BEAST2 that combines the accuracy of methods based on the structured coalescent with the computational efficiency required to handle more than just few populations. We illustrate the potentially severe implications of poor model choice for phylogeographic analyses by investigating the zoonotic transmission of Ebola virus. Whereas the structured coalescent analysis correctly infers that successive human Ebola outbreaks have been seeded by a large unsampled non-human reservoir population, the discrete trait analysis implausibly concludes that undetected human-to-human transmission has allowed the virus to persist over the past four decades. As genomics takes on an increasingly prominent role informing the control and prevention of infectious diseases, it will be vital that phylogeographic inference provides robust insights into transmission history. Hide abstract
Nat Commun, 5 pp. 3956. Read abstract | Read more2014. Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus.
Horizontal gene transfer is an important driver of bacterial evolution, but genetic exchange in the core genome of clonal species, including the major pathogen Staphylococcus aureus, is incompletely understood. Here we reveal widespread homologous recombination in S. aureus at the species level, in contrast to its near-complete absence between closely related strains. We discover a patchwork of hotspots and coldspots at fine scales falling against a backdrop of broad-scale trends in rate variation. Over megabases, homoplasy rates fluctuate 1.9-fold, peaking towards the origin-of-replication. Over kilobases, we find core recombination hotspots of up to 2.5-fold enrichment situated near fault lines in the genome associated with mobile elements. The strongest hotspots include regions flanking conjugative transposon ICE6013, the staphylococcal cassette chromosome (SCC) and genomic island νSaα. Mobile element-driven core genome transfer represents an opportunity for adaptation and challenges our understanding of the recombination landscape in predominantly clonal pathogens, with important implications for genotype-phenotype mapping. Hide abstract
Genome Res., 24 (5), pp. 839-49. Read abstract | Read more2014. Predicting the virulence of MRSA from its genome sequence.
Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and adhesion, the ability to adhere to human tissues, are the major virulence factors of many bacterial pathogens, including Staphylococcus aureus. Here, we assayed the toxicity and adhesiveness of 90 MRSA (methicillin resistant S. aureus) isolates and found that while there was remarkably little variation in adhesion, toxicity varied by over an order of magnitude between isolates, suggesting different evolutionary selection pressures acting on these two traits. We performed a genome-wide association study (GWAS) and identified a large number of loci, as well as a putative network of epistatically interacting loci, that significantly associated with toxicity. Despite this apparent complexity in toxicity regulation, a predictive model based on a set of significant single nucleotide polymorphisms (SNPs) and insertion and deletions events (indels) showed a high degree of accuracy in predicting an isolate's toxicity solely from the genetic signature at these sites. Our results thus highlight the potential of using sequence data to determine clinically relevant parameters and have further implications for understanding the microbial virulence of this opportunistic pathogen. Hide abstract
Lancet Infect Dis, 13 (2), pp. 137-46. Read abstract | Read more2013. Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study.
BACKGROUND: Tuberculosis incidence in the UK has risen in the past decade. Disease control depends on epidemiological data, which can be difficult to obtain. Whole-genome sequencing can detect microevolution within Mycobacterium tuberculosis strains. We aimed to estimate the genetic diversity of related M tuberculosis strains in the UK Midlands and to investigate how this measurement might be used to investigate community outbreaks. METHODS: In a retrospective observational study, we used Illumina technology to sequence M tuberculosis genomes from an archive of frozen cultures. We characterised isolates into four groups: cross-sectional, longitudinal, household, and community. We measured pairwise nucleotide differences within hosts and between hosts in household outbreaks and estimated the rate of change in DNA sequences. We used the findings to interpret network diagrams constructed from 11 community clusters derived from mycobacterial interspersed repetitive-unit-variable-number tandem-repeat data. FINDINGS: We sequenced 390 separate isolates from 254 patients, including representatives from all five major lineages of M tuberculosis. The estimated rate of change in DNA sequences was 0.5 single nucleotide polymorphisms (SNPs) per genome per year (95% CI 0.3-0.7) in longitudinal isolates from 30 individuals and 25 families. Divergence is rarely higher than five SNPs in 3 years. 109 (96%) of 114 paired isolates from individuals and households differed by five or fewer SNPs. More than five SNPs separated isolates from none of 69 epidemiologically linked patients, two (15%) of 13 possibly linked patients, and 13 (17%) of 75 epidemiologically unlinked patients (three-way comparison exact p<0.0001). Genetic trees and clinical and epidemiological data suggest that super-spreaders were present in two community clusters. INTERPRETATION: Whole-genome sequencing can delineate outbreaks of tuberculosis and allows inference about direction of transmission between cases. The technique could identify super-spreaders and predict the existence of undiagnosed cases, potentially leading to early treatment of infectious patients and their contacts. FUNDING: Medical Research Council, Wellcome Trust, National Institute for Health Research, and the Health Protection Agency. Hide abstract
N. Engl. J. Med., 369 (13), pp. 1195-205. Read abstract | Read more2013. Diverse sources of C. difficile infection identified on whole-genome sequencing.
BACKGROUND: It has been thought that Clostridium difficile infection is transmitted predominantly within health care settings. However, endemic spread has hampered identification of precise sources of infection and the assessment of the efficacy of interventions. METHODS: From September 2007 through March 2011, we performed whole-genome sequencing on isolates obtained from all symptomatic patients with C. difficile infection identified in health care settings or in the community in Oxfordshire, United Kingdom. We compared single-nucleotide variants (SNVs) between the isolates, using C. difficile evolution rates estimated on the basis of the first and last samples obtained from each of 145 patients, with 0 to 2 SNVs expected between transmitted isolates obtained less than 124 days apart, on the basis of a 95% prediction interval. We then identified plausible epidemiologic links among genetically related cases from data on hospital admissions and community location. RESULTS: Of 1250 C. difficile cases that were evaluated, 1223 (98%) were successfully sequenced. In a comparison of 957 samples obtained from April 2008 through March 2011 with those obtained from September 2007 onward, a total of 333 isolates (35%) had no more than 2 SNVs from at least 1 earlier case, and 428 isolates (45%) had more than 10 SNVs from all previous cases. Reductions in incidence over time were similar in the two groups, a finding that suggests an effect of interventions targeting the transition from exposure to disease. Of the 333 patients with no more than 2 SNVs (consistent with transmission), 126 patients (38%) had close hospital contact with another patient, and 120 patients (36%) had no hospital or community contact with another patient. Distinct subtypes of infection continued to be identified throughout the study, which suggests a considerable reservoir of C. difficile. CONCLUSIONS: Over a 3-year period, 45% of C. difficile cases in Oxfordshire were genetically distinct from all previous cases. Genetically diverse sources, in addition to symptomatic patients, play a major part in C. difficile transmission. (Funded by the U.K. Clinical Research Collaboration Translational Infection Research Initiative and others.). Hide abstract
Proc. Natl. Acad. Sci. U.S.A., 109 (12), pp. 4550-5. Read abstract | Read more2012. Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease.
Whole-genome sequencing offers new insights into the evolution of bacterial pathogens and the etiology of bacterial disease. Staphylococcus aureus is a major cause of bacteria-associated mortality and invasive disease and is carried asymptomatically by 27% of adults. Eighty percent of bacteremias match the carried strain. However, the role of evolutionary change in the pathogen during the progression from carriage to disease is incompletely understood. Here we use high-throughput genome sequencing to discover the genetic changes that accompany the transition from nasal carriage to fatal bloodstream infection in an individual colonized with methicillin-sensitive S. aureus. We found a single, cohesive population exhibiting a repertoire of 30 single-nucleotide polymorphisms and four insertion/deletion variants. Mutations accumulated at a steady rate over a 13-mo period, except for a cluster of mutations preceding the transition to disease. Although bloodstream bacteria differed by just eight mutations from the original nasally carried bacteria, half of those mutations caused truncation of proteins, including a premature stop codon in an AraC-family transcriptional regulator that has been implicated in pathogenicity. Comparison with evolution in two asymptomatic carriers supported the conclusion that clusters of protein-truncating mutations are highly unusual. Our results demonstrate that bacterial diversity in vivo is limited but nonetheless detectable by whole-genome sequencing, enabling the study of evolutionary dynamics within the host. Regulatory or structural changes that occur during carriage may be functionally important for pathogenesis; therefore identifying those changes is a crucial step in understanding the biological causes of invasive bacterial disease. Hide abstract


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Product Description
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Question about Computers & Internet
Posted by liron_tova on
but how do i uninstall it if everytime i turn it on it freezes. someone suggested doing it in safe-mode, but even then it freezes.
to clarify,
i can get it into safemode, but then it freezes still, so i cant uninstall... also i dont know how to do this?
can you go in safe mode? If this is a new product you should have frree support from Symantec. At the least try safe mode and see if you can uninstall or do a system restore. Do you know how to do either of those?
Most likely a problem with Norton, you should try to uninstall norton.
You can do this in safe mode.
Reboot and keep hitting F* to get the safe mode option screen.
Tutorial Link
Post back here with any new info.
Posted on Dec 07, 2008
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Baja Front Bulk Head Set by HPI Racing
HPI Racing
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This product was added to our catalog on March 12, 2008.This is a replacement HPI Baja Front Bulk Head Set. This package also includes the necessary mounting hardware.


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College math
posted by Meg .
Can someone please assist me
The problem reads "use the rule of 78 to find the payoff amount for the loan paid in full before the date"
Finance charge: $717
Total number of payments 41
Amount per payment $155
Remaining payments when paid in full 10
Please help. Thanks in advance


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- This event has passed.
Mustard Seed Legal Clinic
April 24 @ 1:30 pm - 3:00 pm
|Recurring Event (See all)
An event every 1 month(s) on that lasts 0 day(s) and 1.5 hour(s) with no end date
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Evelyn F. Restivo Is a Bride
Published: April 30, 1989
Evelyn Frances Restivo, a daughter of Mr. and Mrs. Nicholas Restivo of Irving, N.Y., was married yesterday to David Elmslie Moore Jr., a son of Mr. and Mrs. Moore of Rye, N.Y. The Rev. Daniel E. Budd officiated at the Unitarian Universalist Church in Buffalo.
Elaine A. Restivo was her sister's matron of honor. Roger Hawkins served as the best man.
Mrs. Moore is a graduate of Charter Oak College. Her father owns and operates vineyards under his name in Irving. She is a granddaughter of the late Mr. and Mrs. Samuel Restivo of Silver Creek, N.Y., and the late Mr. and Mrs. Angelo Del Bosco of Buffalo.
Mr. Moore is the executive director of the Playwrights' Center, a professional theater organization in Minneapolis. He graduated from the Putney School and Harvard University and attended the Yale School of Drama.
The bridegroom is a great-grandson of the late Joseph Pulitzer, the newspaper publisher, and is a descendant of Clement Clarke Moore, the author of ''A Visit From St. Nicholas.'' He is a grandson of the late Mr. and Mrs. William S. Moore of New York and Bar Harbor, Me., and the late Mrs. Livingston Cromwell of New York and the late Frederic Cromwell of San Francisco.
The bridegroom's father is the president and executive editor of the monthly magazine Northeast International Business; he is also a director and a member of the executive committee of the Pulitzer Publishing Company in St. Louis. The bridegroom's mother, Katherine Moore, is associated with the Katonah (N.Y.) Gallery, a teaching museum.
David and Evelyn Moore


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handmade Mother's Day card ... monochromatic lavenders ... gorgeous die cut butterfly from Marianne Dies ... lots of texture from two different texture plates ...
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text: Picking The Right Interior Doors For Your Home It is important to decide the right interior door when you build a new house or remodeling a house as it makes a huge statement in your home. They enhance the style and ambience of the room. Doors are fitted in the living rooms, closets, bedrooms, and bathrooms. check my site on the ways to pick the right interior doors.consumerreports.org is a website on reviews by customers about the different interior doors available in the market. The article below gives an overview of the different types of interior doors available in the market. It also helps in choosing the best indoor door type for your home. Interior Door Styles There are different types of interior door styles available. You can select the appropriate style that suits the needs. The door type can also be decided based on the size of the room. The different types of doors are highlighted below: Panel doors are mostly used in many of the houses. They come in square or rectangular panels. The panels are decorated and also provided with glass. Flush Door is one of the simplest door types which is entirely flat. It gives a classic look to the room. It is widely used as it is affordable to all the people. Bi-fold doors can be used when you face space constraints. They swing does not open up, but it can be folded into each other. This gives more space for the room. They are mostly used in bedroom closets, pantry area, and laundry rooms. French doors are fixed mainly in the entryway of rooms. It consists of two hinges hung towards mounted on either side. Decorative panels and glasses in the doors add glamour to the room. They are used in living room, home offices, bedrooms, etc. Sliding doors are the best option when there is no space for the door to swing open. The door slides along the wall thus save the floor space available. These doors are used very rarely. Pocket doors are a single door that slides within the wall. These doors are used in small spaces like toilets and passages. Final Touch To Interior Doors. Painting the doors or providing a stain finish gives a good look to the door. The different options available are Stain Finishes There are different types of stain finishing available. The popular stain is the wood stains. It gives a traditional feel to the doors. They also give a classic look to the room. Wooden stains come in different colors. The type of the stain is decided based on the material of the door. Stains are done in solid wood doors as it emphasizes the grains. Paint Finishes To add color and charm to the existing indoor door, the best option to paint the doors with the apt colors. Painting the door gives a contemporary feel to the house. The door manufacturer can help you with the various finishing options available. The above article has given a detailed description of the various door styles available. It also suggests certain finishing options that aid in giving a final touch to your interior doors. Share on Facebook Share Share on TwitterTweet Share on Google Plus Share Share on Pinterest Share Share on LinkedIn Share Share on Digg Share March 17, 2017 Comments are closed. Leave a Reply Cancel replyYou must be logged in to post a comment. « Best Innerspring Mattress For Back Pain Relief Choosing A Remote Car Starter Made Easy » Recent Posts Things To Look For In A Whiskey Decanter Choosing A Remote Car Starter Made Easy Picking The Right Interior Doors For Your Home Best Innerspring Mattress For Back Pain Relief Choose And Use A High-Quality Anti Snoring Mouthpiece Don't Miss Updates Archives April 2017 March 2017 January 2017 December 2016 November 2016 September 2016 July 2016 June 2016 March 2016 December 2015 November 2015 October 2015 September 2015 Categories Blog Fashion Gift Shopping Shopping Adventure Uncategorized TagsADVENTURE Anti Snoring Mouthpiece Best Trench Coats Casual Dresses casual wears Gold Teeth Golf Rangefinder Interior Doors latest trends Lightings Mattress For Back Pain Relief Pair Of Shoes Quilting Machines Remote Car Starter Return Gifts for Kids rigid foot Scheduling Software shoe Shopping Services Vein Treatments Whiskey decenter Wholesale Fireworks Yoga Mat


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Knee Pain in Left Leg
I feel knee pain in my left leg while riding stairs. It's for the past one month. It started all of sudden w/o any injury. I don't know. Used ointment for temp. relief but it's not fully cured. Planning to consult a doc. If possible, Can you please suggest me any help here? Thanks.
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That is knee strain, avoid stairs climbing, develop thigh muscle strength by brisk walking and static quadriceps exercises
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text: We are so stoked about the 2014 live lit calendars, they're $12 each, and list over 40 live lit events in Chicago each and every month. They also feature post-it note portraits of everyone who's read with us during our first year – did I mention this month is our anniversary?! Well IT IS!!! Come see us on Sunday, October 13th for a fabulous lineup, and pick up a calendar while you're there!


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ग्राउंड रिपोर्ट- माफ होगा किसानों का कर्ज? सरकार पर पड़ेगा 62 हजार करोड़ का भार
Apr 4, 2017
'एक विलेन' को तीन स्टार
Jun 27, 2014
चुनावी चोले में अयोध्या के साधु
May 5, 2014
Tubelight Song Naach Meri Jaan: Of Salman Khan And His Bhai
India News | Thursday June 1, 2017
The second song of Salman Khan's much-awaited film Tubelight was unveiled by the makers of the film today. The song, titled Naach Meri Jaan celebrates the brotherhood
Tubelight's The Radio Song Is Out. Salman Khan Will Win Your Heart With His Dance Moves
India News | Tuesday May 16, 2017
Salman Khan along with filmmaker Kabir Khan and Sohail Khan launched the first song from Tubelight, titled The Radio Song in Dubai
Baahubali 2: Kamaal R Khan's U-Turn After His 'Rajamouli Fooled Public' Tweet
Tuesday May 9, 2017
Suddenly, Kamaal R Khan is all praises for Rajamouli and Baahubali 2, after he dismissed the film in the most unflattering manner last week
Kamaal R Khan Apologises To Mohanlal For Calling Him 'Chhota Bheem', Says 'Didn't Know' He's 'Superstar'
Sunday April 23, 2017
KRK also offered an explanation along with his apology, saying that he was unaware of Mohanlal's status as a 'superstar of Malayalam films'
Kamaal R Khan Trolled For Calling Mohanlal 'Chhota Bheem.' But He Doesn't Care
Thursday April 20, 2017
On Twitter, KRK shifted his attention to Mohanlal after it was announced that the veteran actor will play Bheem in the ambitious 1000 crore budget Mahabharata
As Yogi Adityanath Drops 'Samajwadi', Akhilesh Yadav's Party Quotes Shakespeare
India News | Reported by Kamaal Khan, Edited by Ipsita Sarkar | Friday April 7, 2017
The Yogi Adityanath government has stripped the word "Samajwadi" from government schemes and replaced it with "Mukhyamantri" (chief minister). So the Samajwadi ambulance service in UP will now be called the "Mukhyamantri ambulance service." This applies to everything in the UP government that former Chief Minister Akhilesh Yadav had named after his...
Swara Bhaskar Responds Angrily To Kamaal R Khan's 'Unasked Filth' About Her New Film Anarkali Of Aarah
Tuesday February 21, 2017
Kamaal R Khan dismissed Swara Bhaskar's upcoming film Anarkali Of Aarah in the most unflattering terms. In a tweet addressed to Karan Johar, KRK predicted that the film would be a 'super duper disaster of the year coz KRK says so'
Ajit Singh Not Into Grand Alliance. Well, Nor Are We, Says Team Akhilesh
India News | Reported by Kamaal Khan and Alok Pandey, Written by Suparna Singh | Thursday January 19, 2017
Having recently belled one cat - belligerent father Mulayam Singh - Akhilesh Yadav is now busy dealing with another - regional heavyweight Ajit Singh, who heads the Rashtriya Lok Dal or RLD, and is an integral part of Akhilesh Yadav's strategy for a Grand Alliance, prototype Bihar, in the coming Uttar Pradesh election.
Forced Out Of Ramlila Show, Nawazuddin Siddiqui Says 'Childhood Dream' Crushed
India News | Reported by Kamaal Khan | Friday October 7, 2016
In a video posted on social media, actor Nawazuddin Siddiqui tosses out animated, high-pitched dialogue while rehearsing a scene from the Ramlila. He is also seen in full costume.
Ajay Devgn vs KRK: It's War, Bollywood-Style. What You Need to Know
Friday September 2, 2016
"Karan Johar has never offered me money. I will review the two films and will review accordingly. Ajay Devgn has shown that he has no belief in his own product which he has shown. He should fight like a man with Karan Johar and not drag me in the middle," said Kamaal R Khan
Ajay Devgn Posts Clip of KRK Claiming KJo Paid Him. KRK Now Says This
Friday September 2, 2016
The rival films are releasing together this Diwali. On Twitter, KRK has dismissed Ajay's film as 'Himmatwala 2,' a reference to the flop film he starred in a couple of years ago
KRK Apologises to Vikram Bhatt, 'Thanks For Showing Me The Right Way'
Indo-Asian News Service | Sunday July 3, 2016
"Today I watched @TheVikramBhatt n he said-KRK has got big social media power so he should decide whether he wants to be. Recognised as a troll only or respected critic n I am 100% agree with his statement. So thanks to @TheVikramBhatt for showing me right way. (sic)," KRK tweeted
What Sidharth Malhotra Has to Say About Kamaal Khan
Indo-Asian News Service | Monday April 4, 2016
When Sidharth was asked how he takes up all the social media trolls including this latest incidence, Sidharth said: "I don't want to give any more energy or interest because it will add to his negative thoughts. I think that's about it"
Salman Khan Withdraws Plea From Supreme Court To Summon Kamaal Khan As Witness
India News | Press Trust of India | Friday December 11, 2015
A day after the Bombay High Court acquitted Salman Khan in the 2002 hit-and-run case, the actor today withdrew his plea from the Supreme Court seeking examination of his friend and singer Kamaal Khan as court witness in the case.
Can't Convict Salman Khan Based on Current Evidence, Says Court
Thursday December 10, 2015
The court also said that singer Kamaal Khan, who was also in Salman Khan's car that night, should have been examined. Last month, Mr Khan's plea to make Kamaal Khan a witness in the case was dismissed by the court. "The defence brought the witness at an appropriate time, it is not delayed defence," said the court, dismissing the prosecution's argum...
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Army 2013 Preview: Two Relief Routes
One of the enduring and iconic images produced by the 2012 college football regular season came in its final moments.
Army-Navy, the last game of each regular season in the Football Bowl Subdivision, twisted and turned its way to the closing minutes of regulation with Army driving, driving, driving, on the doorstep of a glorious and transformative triumph. The Black Knights were in the red zone, slowly but powerfully pushing through Navy's sagging defense. The Brave Old Army Team really did seem to be on its way to slaying the demon known as the decade-long losing streak to the boys from Annapolis. Yes, the Black Knights were just 14 yards from registering an achievement that would have electrified the program and given a fresh dose of optimism to anyone and everyone who cares about West Point football.
But then it happened.
Fumble-itis, a disease which has infected Army's program for most of the past three years, raged its ugly head again, and in a heartbeat, Army hearts were not just broken, but crushed into fine powder. CBS cameras, naturally in search of good visuals, fixed their sights on Steelman, who cried the manly tears of a formidable competitor who just couldn't summon up enough clean plays to finish that drive. Yes, CBS lingered on Steelman a bit too much, but the image was unforgettable just the same. Effort – never a problem for Army – was not the reason the Black Knights had to sing their alma mater first once again in Philadelphia.
It was, as usual, execution – perhaps by a smaller margin this time, but the notion of "smallness" doesn't really hold much value in an event as large as Army-Navy.
Steelman – who gave everything to Army football – will not don a helmet for the Black Knights this season. New players will step into his place and into other positions as well. Yet, even though players come and go in rapid succession in college sports, it remains a point of fascination that programs can retain the same characteristics over an extended period of time. Over the past 10 years, Army has continued to manifest many of the same bad habits and tendencies, while Navy – 2011 excepted – has managed to consistently find winning formulas in crunch time more often than not. Army can't worry about Navy's ability to do well, but the Black Knights can certainly change their propensity to fall one or two plays short.
How does Army climb the hill? How does Army get over the hump? How does Army find sweet, transformative relief in 2013?
There's the long way, and there's the short way. The long way, though, is not a less desirable path – not if it gets Army where it needs to go. The short way is not a "cheap" ticket to prosperity, somehow gained with less than substantial effort. It's rather simple to unpack these two concepts and what they mean for head coach Rich Ellerson and company.
The long way and the short way are nothing more than references to the kinds of scoring drives a football team can produce. The long way is the 15-play, 80-yard drive. The short way is the 70-yard run or the 40-yard pass. They're both good – one really isn't better than the other – but the key is that Army finds a way to reach the end zone by at least one of the two paths when it really matters.
The long way is valuable to Army because it keeps the opposing offense on the sidelines and rests the Black Knights' defense. The long way is also important to this program because the triple option is supposed to slowly sap an opposing defense of its stamina, intensity and concentration. The triple option is meant to unnerve a defense and then – as a result of said unnerving – hit the big play precisely because a linebacker or safety gets mentally tired of playing sound assignment football. It is well within Army's ability to use "The Long Way" to its advantage, but as the Navy game and also the Rutgers loss showed in 2012, the Black Knights could only travel four-fifths, three-fourths, or two-thirds of the field before bogging down. Slow, drip-by-drip drives rarely ran their course. The red zone – not the goal line – is where all too many Army drives died last season. Using "The Long Way" means that Army has to get those final 15 or 10 yards this season. You don't know which game will bring forth this need for the Black Knights (though Navy is a likely candidate), but you do know that the need will indeed arise at some point.
However, if the long way isn't always taken by the Black Knights, the short way will work just fine, too.
One underrated way of dealing with red-zone problems is, of course, to complete a 40-yard touchdown pass or bust off a 50-yard touchdown run. Army's problem here, of course, is that it typically lacks the breakaway speed in the backfield to produce such runs. The team's triple-option attack is not a snug and comfortable home for polished pocket passers. Yet – and this is something that gets talked about each and every season – the reality of the triple-option offense is that the constant use of the running game sets up the possibility of an unexpected deep ball. Army, if it wants to beat Navy and produce a .500 season in 2013, has to find this little bit of big-play lightning at some point – not in every game, but certainly in some situations.
It's a bit too extreme to say that Army (or any college football team) has no options. Teams in the modern age of this sport always have options; they just have some options that are strengths and some that are weaknesses. Army's strength is clearly closer to The Long Way than The Short Way. However, winning teams find ways to enhance their weakest points. Winning teams find ways to win with different styles of play, because on some days, the preferred mode doesn't click, thereby requiring the use of a backup approach.
If you go back 100, 90, 80, or even 50 years ago, college football offenses were just not as developed, layered, or quarterback-centric as they are now. As Ralph D. Russo of The Associated Press and many other top-flight college football writers have been saying over the past few years, this is a time in the sport's history that is ruled by offense. We have seen waves of innovation in the sport since the mid-1960s and especially the past 10 to 15 years. If you're not finding ways to pry open opportunities on offense – via the long way or the short way – chances are you're not winning.
Army has to find more ways to score touchdowns in 2013. By itself, that statement is not a revelation. Hopefully, though, the explanation given above will enable you to appreciate why this notion of having multiple ways of scoring is so essential for West Point football this fall.
That's the long and short of it.
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London, July 4 : Even as the "peerage controversy" is snowballing into a major controversy in London, British Prime Minister Gordon Brown has told Keith Vaz, a parliamentarian and chairman of a parliamentary committee, that he never tried to bribe him in return of his crucial vote which saved his status as the Leader of the Labour party on June 12.
Keith Vaz, the chairman of the Commons Home Affairs Committee, challenged Gordon Brown to confirm he was not bribed ahead of the vote on 42 days. Appearing alongside other committee chairman at their regular grilling of the Prime Minister, Vaz asked Brown about the Telegraph's revelation that he received a letter from Geoff Hoon, the Chief Whip, saying he hoped he would be "rewarded" for supporting the Government's anti-terror plans.
At the Westminster hearing Vaz asked Brown: "You only got your legislation through by nine votes. Is it the case that you authorised or offered any backbench Member of Parliament a peerage or a knighthood or honour, or even the Governorship of Bermuda in order to vote for your legislation?"
Brown replied: "Not at all. Nor do I recall sending any letters to anyone," reported The Telegraph.
Vaz then questioned whether any promises were made to members of the Democratic Unionist Party, who also unexpectedly supported the legislation, but did not ask the Prime Minister whether any other inducements were offered.
At the two-and-a-half-hour grilling, Mr Brown faced questions on issues ranging to the credit crunch to climate change and the situation in Iraq, Afghanistan and Zimbabwe.


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text: The Canteen Cafe used to be open 24 hours where the Embers Bridgeman's is today. I don't remember ever eating there and I only occasionally remember the Embers these days. Don't go to the Embers looking for "atmosphere." You won't get it. If your looking for a fine burger try the Emburger Royale. They'll bring you a large mound of fries, right out of the fryer. Embers and Bridgeman's are local, so you can feel good about supporting something your grandmother probably approved of. While your there you might want to check out the old Parkway Motel Totem Pole. It's lying on it's side behind the building.


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Moments after the defeat that was difficult to swallow for Irish faithful, Notre Dame's locker room was deflated and left searching for answers, caught in the middle of a four-game losing streak.
"Frustration," was the only word Luke Harangody could muster up after some thought. "I mean, four in a row, all of them tight games that we should win, especially these last two at home. We need to dig deep right now, dig deep and stay together and find it, because obviously it's not out there. We got beat by men tonight, and we didn't play like men."
Senior point guard Kyle McAlarney went as far as to say that he was worried.
"Yeah, I mean, worried, angry, disappointed," he said of his emotions after the loss. "When you look at the rankings and see the standings, you definitely get worried, because we don't have anything right now, we don't have the next NCAA bid, but we're fighting for that right now. When you see the standings and you see our record, worry, you know, you definitely feel a sense of worry."
Notre Dame (12-7, 3-5) came out in a different starting lineup, replacing Zach Hillesland with Luke Zeller and Ryan Ayers with Jonathan Peoples. Both of the new starters gave coach Mike Brey solid minutes and production, but the two seniors relegated to come off the bench went scoreless in the contest. Marquette (18-2, 7-0) on the other hand stuck to its horses and received standout performances from its prolific scoring quartet of Lazar Hayward, Dominic James, Wesley Matthews and Jerel McNeal who picked up 13, 15, 16 and 27 points respectively. In fact, Maurice Acker was the only other player to attempt a shot, and no other Marquette player managed to even score a point besides the foursome.
The contest started out with a quick pace, as both squads began to trade baskets. Unlike Marquette, however, the Irish scoring came primarily from only two players — Harangody and Zeller. In the first half, the duo combined for 10-of-15 shooting for 25 points. The rest of Notre Dame's team went a combined 1-for-17 from the field, a McAlarney three-pointer. Zeller finished with eight points to add on to his eight boards, and Tory Jackson added 10 points and seven assists. Once again, Harangody was the focal point, ending up with game-highs in points and rebounds with 29 and 17 respectively.
After McAlarney delivered his three-pointer early on to tie the game at five apiece, he then called for a pick on the next possession, which Harangody delivered, followed by a quick cut to the basket for an easy finish to put the Irish up two. James pushed the tempo on the ensuing possession finishing with a fastbreak layup to tie the contest at seven. After the reigning Big East Player of the Year hit a 10-foot jumper from the right baseline, Hayward knotted up the game once again with a short floater. Then Harangody continued his assault, this time from beyond the arc, however, with a three-pointer as the shot clock expired. The Golden Eagles would continue to trade a basket for another, as McNeal came off a screen with his own long-range three to tie the score up at 12. Harangody then answered with another long-range shot, this one good for two.
After McNeal drove to the lane to knot the contest up once again, he completed the three-point play to put Marquette up 15-14. From that point on, the Golden Eagles would hold the lead for the majority of the contest, up until 16 minutes to play in the second half. Marquette continued to benefit from McNeal's ability to drive into the paint and finish, eventually going into halftime up 33-30.
Later in the contest, after a pair of McAlarney free throws put the score at 63-61 in favor of the Golden Eagles, the Irish were looking to make a run and close the gap. McNeal, once again, was there to ensure that this would not be the case. In a play that seemed to be going nowhere, Tyrone Nash nearly stole the inbounds pass, but the ball eventually made its way into McNeal's hands. With Harangody charging hard in an attempt to alter his shot, McNeal simply stayed poised and drained the back-breaking three-pointer, putting Marquette up five. The next trip down the court, McAlarney hoisted a long-range three that fell wide right and into the hands of Marquette. Eventually, Matthews was fouled, and converted his two free throws to put the score at 68-61, and the game out of reach for the Irish.
"I remember what we were running, and it didn't flow very efficiently prior to getting the ball to Rel," Marquette head coach Buzz Williams said of McNeal's game-changing shot. "He's very impulsive and very instinctive and what he does on both ends of the floor, obviously that was a big possession."
Now that Notre Dame is wounded and reeling in the Big East, the faces on the players depicted a need for a resolution to the squad's problems after the defeat. According to Zeller, the resolution starts with introspection of each individual member of the unit. However, the senior center is not one to make excuses.
"I mean, like you said, there's no excuses for it," he said of the four-game losing streak. "We have a challenge every single night, whether it be a team that is ranked, or a team that's not ranked. You've got teams at the bottom half of the league that are capable of doing big things and upset the teams on a nightly basis, so every single game in this league is a tough game, and it's going to be a tough stretch the rest of the way, but we just have to dig in and find a way to win."
No one knows this better than Brey, who knows how to treat this squad after its recent brutal stretch.
"It's not cub scouts, man," Brey said. "We signed up for the Big East and this is tough, so I'm not holding any hands. Either grow up and deliver, or don't play. That's where we're at. We're going to go play Pittsburgh, who arguably is the toughest team in the league, so it's all about your leadership stepping forward and we've got good leadership and solid guys, they'll rally, but I'm not giving massages and telling guys they're beautiful. Either you deliver or you don't play."
To start the weekend, Notre Dame was hoping to keep its consecutive home winning streak alive. After Saturday's loss, the Irish were hopeful of picking up a win Monday night to split the home series. Now, after a its most recent loss to Marquette, Notre Dame is hoping for something else — a win.


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As a Customer Service specialist, you are the central contact point for internal as wel as external relations. In addition, you are responsible for all order management flows.
- You are contact person for international clients, with regard to questions about products, delivery and pricing.
- You coordinate the order management process.
- You solve problems and complaints regarding orders.
- You are contact person for internal departments
- You are pro-active when orders are changing or delayed.
- You ensure good relationships
- You participate in project teams.
In order to qualify for this international and fulltime International Customer Service Specialist position, you should meet the following requirements:
- Education at bachelor's level.
- At least 3 years experience in an international Customer Service position.
- Speaking fluently English and Dutch, speaking German is a significant advantage.
- Excellent knowledge of SAP.
- Fulltime available.
A challenging and varied role within a large international organization. Next to that, the organization values the development of their employees. Salary is competitive and has a maximum of €2650 gross each month on the basis of 40 hours a week.
Ref: CX6555
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Enter your answers to win a $100 electric bill credit!
Money For Your Thoughts is a monthly contest featured in Electric Consumer. You can submit your answers to the questions by cutting and mailing the completed questions from the magazine or completing the online submission below. Each month, we draw three winners of a $100 electric bill credit.
On Friday, June 16, we will draw three names from the website and mail entries combined. If you have the correct answers and your name is drawn, you'll receive a $100 credit on your next electric bill. The winners will be notified, posted on this page and listed in a future Electric Consumer.
May 2017 Winners: Thomas & Wendy Brackett, Melony Harkenrider & Billy Jarvis, and Jane Kinyon. Congratulations!
June 2017 questions
- Visiting The Black Sparrow, Nick Rogers discovered ______-wrapped dates – perfectly proportioned in size, flavor and sweet-savory contrast.
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Unformatted text preview: ACT240H1 F09 Outline v01 UTSG-ACT240H1 F09 (Preliminary Draft Version Sep 2, 2009) Lecture M 10:00-12:00 pm MP102 (first Sep 14) Tutorial F 10:00-11:00 pm MP102 (first Sep 25) Instructor and office hours Keith Sharp PhD FSA FCIA CFA [email protected] http://fisher.utstat.utoronto.ca/sharp M 09:00-10:00 am M 04:00-05:00 pm T 11:30-12:30 pm T 04:00-05:00 pm R 11:30-12:30 pm UTSG-SS5027C? UTM -South2110T? UTSC- SW632A? UTSG-SS5027C? UTSC-SW632A? TA: ?????? Topic Coverage Lecture and test date L01: Sec 01: Effective rates Sep 14 L02: Sec 02: Effective rates Sep 14 L03: Sec 02; Nominal rates, credit cards Sep 21 L04: Sec 03: Force of int, inflation Sep 21 L05: Sec 04: Annuity Sep 28 L06: Sec 04; Annuity (cont) Sep 28 TERM TEST 1 in usual lecture room Oct 05 10:00 am L07: Sec 05: Annuity at any time point Oct 05 11:00 am THANKSGIVING Oct 12 L08: Sec 05: Annuity at any time (cont) Oct 19 L09: Sec 06: Different int and payt periods Oct 19 L10: Sec 07: Geometric prog of payments Oct 26 L11: Sec 07: Geom payts, indexed pension Oct 26 L11a: Sec 08: Arithmetic payments Oct 26 TERM TEST 2 in usual lecture room Nov 02 10:00am L12: Sec 09: Amortization of loan Nov 02 11:00am L13: Sec 09: Amortiz of loan, mortgage Nov 09 L13a: Sec 10: Sinking funds Nov 09 L14: Sec 11: Bond valuation Nov 09 L15: Sec 11: Bond valuation (cont) Nov 16 L15a: Sec 12: Bond amort, callables Nov 16 L16: Sec 13: Return on fund Nov 16 L17: Sec 13: Return on fund (cont) Nov 23 L00: Exam run-up Nov 23 L00: Exam run-up Nov 30 L00: Exam run-up Nov 30 FINAL EXAM Dec 09-18 Participation Lasers Please leave your participation laser in the box/bag/pile at the end of every lecture: I buy them personally from dollar stores in the hope that you will find the easy participation valuable. stores in the hope that you will find the easy participation valuable....
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This note was uploaded on 12/21/2010 for the course ACT act240 taught by Professor Act during the Fall '07 term at University of Toronto.
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£3,950,000 Guide Price
9 Bedrooms Detached House for sale
Hockworthy, Wellington, Devon, TA21
A spectacular newly refurbished and immaculate former rectory - hockworthy house has all the amenities of a modern day country house, occupying an elevated and peaceful position, with…
£2,000,000 Guide Price
5 Bedrooms Detached House for sale
Nynehead, Wellington, Somerset, TA21
A truly bespoke south facing modern country house. 6 reception rooms, kitchen/breakfast/ family room, cinema room, ground floor wet room, principal master suite, four further bedrooms,…
£2,000,000 Guide Price
6 Bedrooms Detached House for sale
Nynehead, Wellington, Somerset, TA21
A bespoke 5 bedroom country house for sale in a rural location ta21 - the lynch is a truly unique country property in a stunning rural location near wellington. the property faces…
£1,995,000 Guide Price
20 Bedrooms Detached House for sale
Holcombe Rogus, Wellington, Somerset, TA21
An outstanding lifestyle property combining owners 5 bed barn conversion, annexe and equestrian holding with an exceptional holiday business. 7 holiday lodges, p/p for 4 more. all…
£1,045,000 Guide Price
7 Bedrooms Detached House for sale
Appley, Stawley, Wellington, Somerset, TA21
A flexible residential holding in a favoured hamlet, with outbuildings and grounds extending to 47.49 acres. grade ii farmhouse with ancillary accommodation and stone barn with planning…
Whiteball, Wellington, Somerset, TA21
A beautifully situated contemporary barn conversion, affording light, spacious and well appointed accommodation complimented by attractive and established gardens, broad leafed woodland…
£845,000 Guide Price
9 Bedrooms Detached House for sale
Langford Budville, Wellington, Somerset
A handsome and spacious 5 bedroom detached period house with 2 bedroom annexe and 2 bedroom cottage, totalling 6683 sq ft in gardens and grounds extending to 6.75 acres. no chain.freehold
£825,000 Guide Price
5 Bedrooms Detached House for sale
Wellisford, Wellington, Somerset
A beautifully appointed south facing barn conversion offering light and airy 5 bedroom accommodation providing great flexibility as to use, attractively situated around a secluded…
£795,000 Guide Price
7 Bedrooms Detached House for sale
Appley, Stawley, Wellington, Somerset, TA21
Fine equestrian property offering flexible living accommodation with range of outbuildings and grounds of approx 8 acres.
£750,000 Guide Price
5 Bedrooms Detached House for sale
Kittisford, Wellington, Somerset, TA21
A traditionally designed country house located within an unspoilt and tranquil setting. in all about 1.728 hectares (4.271 acres). (contd...)
£750,000 Offers in Excess of
7 Bedrooms Detached House for sale
Ashbrittle, Wellington, Somerset, TA21
A 7 bedroom country house set in over 2 acres for sale near wellington ta21 - a fine period country property with elegant and well-proportioned rooms set a rural, yet edge-of-village…
£650,000 Guide Price
7 Bedrooms Detached House for sale
Near Staple Cross, Wellington, Somerset, TA21
Great potential - farmhouse, cottage, haulage yard/workshop and outbuildings/stables set in 4.5 acres. superb views, 4 bedroom house, 3 bedroom cottage, buildings with potential, 4…
Ashbrittle, Wellington, Somerset, TA21
A rare opportunity to acquire this character property set in the most idyllic rural location, complemented by adaptable outbuildings and land.in total around 16.23 acres
£575,000 Guide Price
5 Bedrooms Semi Detached House for sale
A superb grade ii listed 18th century semi-detached farmhouse with stunning character features, workshops and stables located in beautiful countryside near the village of holcombe…
£525,000 Offers in Excess of
4 Bedrooms Detached House for sale
This is a unique detached property with 1 bed annexe approx. 1 acre gardens situated on the a38 at the somerset/devon border. comprises hall, kitchen, lounge, dining room, garden room,…
Free Instant Valuation
Find out if you are charging enough rent or what your property would be worth if you were to sell now


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Hollywood - Wax Museum
during a trip to the museum there were people there that were saying that they felt cold spots lights going off and on and voices right by the last supper.
Hollywood, California
There are 1050 Haunts nearby
Source: Internet
|Location Approximate!!! Care to correct it?
34.09833, -118.32583


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Adrenaline MobAll art is done, a little bit for self-gratification, but mostly for a love of it and for the people who love what you are doing.
AnathemaWe didn't really sing about another person. We sang about our own lives, as we always did. But it was quite easy to make our songs about us with another person as main character and that is what we did.
Artificial LanguageIt comes and it goes. Sometime the main melody will just come to me. Other times I have to really work for it.
AtavismoBeing original is paramount, and we believe we are, and also we think the most important about playing music is "feeling"…not being a robot, or a stereotype of any music style.
AvatariumMusic is not like learning from a book, music is about writing a book.
AzarathSpeaking about growth I think that we are still developing in songwriting.
Backwood SpiritHe has just good memories from your country, so the Dynamo Metal Fest would be something!
Balkun BrothersThere's so many good sounds out there to be heard, we try to find as much of the good music as we can.
Beyond Our RuinsPijn is mijn inspiratie. Pijn is in mijn beleving de puurste van alle emoties en in het goede altijd het startpunt van schoonheid en gelijk.
Bjorn RiisI was five years old when I first heard Kiss and they've been with me ever since.
Black HawkWe are on fire and are highly motivated!
Dystopia'Archon' en 'Bound to Annihilate' zijn geboren uit mijn nihilistische wereldbeeld en mijn persoonlijke strijd om met dat nihilisme om te gaan. Ik kan soms erg in de knoop raken van het idee dat eigenlijk niets er echt toe doet en die ellende probeer ik in teksten om te zetten.
Heavens DecayBack in the day we had to wait for hours and hours in line for concert tickets, and when we wanted a demo or a t-shirt from a band far away, it took months doing back and forth with hand-written letters and wait for it for months to arrive.
HelmetIn 1999, I was the guitarist of David Bowie´s 'Hours' tour. That was fucking amazing!
Henry KaneIf everyone could tell themselves each morning "Don't be a cunt today!", the world would be a better place.
Iced EarthThe government is the number one killer of humanity on the face of the earth.
IDEK.I Don't Even Kare, in a twisted, bizarre way!
Imperial State ElectricNever give up to rock and roll because rock and roll will never let you down.
Infernäl MäjestyThere is no future for humankind until all religion is abolished or reduced to small pockets of insignificance.
Life's DecemberPain and suffering are and have always been a motivator to change for mankind. People prove every day that there is no such thing as fairness in life, too many crooked beings wander through the day and cause nothing but misery.
MemoriamBirmingham is right in the middle of the country and is fiercely independent; we don't follow trends and are not led by what is fashionable.
MindmazeI'm a perfectionist with pretty poor self-esteem/self-image, if I'm being brutally honest. I don't really know how to properly take compliments, and at the end of the day it rarely silences the self-critiquing voice in my head.
MortörIn terms of Canadian thrash standing out, I'd say that Canadian metal in general tends to have its own vibe. It's cold as hell up here, so I tend to find that Canadian musicians spend a lot more time practicing (not much else to do when it's -30 outside!).
Mountains CraveIt may all be pseudoscientific hogwash, but fascinating nonetheless to speculate about what our ancestors saw of old.
Neo NoirePeople don't buy music anymore. Young people grow up in the thinking that music is for free.
NeurosisIt's a lot to ask anyone to take an hour of their lives to listen to an album you made.
NorseI don't specifically set out to fulfill a set of qualities for each song. I allow the ideas to morph and twist into what they become without restrictions.
PersefoneThis triggers a side discussion during which we elaborate on views of the Universe or maybe the Multiverse.
Red HarvestMore or les all unwritten rules were broken. We implemented very unfamiliar sounds when it comes to traditional metal.
Soul DemiseWe don't sound like At The Gates, the only thing we have in common is that we both play melodic death metal.
Spitting NailsAt this point we are the only Spitting Nails with a release on Spotify.
The WizardsThe Gods of Metal got us in touch.
VoivodWe talked about a dystopian future, and right now it seems we have arrived to it.


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Search Profile Post Profile Log In Membership Plan Site Map
Awarded as Best Matrimonial Site...
Call Us : +91-11-47652233
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Used this hotel for sending my daughter off to collage overseas, Easy of access to the airlines and shuttle bus to return from the airport. Friendly staff with smiles on there faces lots of help with everything. Loved the place!!!
Getting you more information on this room
Getting you more information on this room
"I wouldn't bother with the Executive floor here - very limited choices."


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File Hosting with Short URL Link
Files expire after a set amount of time and then become inaccessible. BitDrop editor allows you to manage files so you can see what others are uploading. Highly customizable, select the length and characters of the short URL and file expiration time. You can also easily integrate BitDrop into your existing website by following the help file or using the included example. Features: Easy to install and configure All functions stored in one PHP class file AJAX Uploading Hotlink protection Limit the number of downloads or file types Select the size of and characters in your URL Select the expire time of your files View and Delete files using the editor Runs on SQLite, NO external database requiredVisit publisher site: File Hosting with Short URL Link
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UWire College Media Blog
4 Ways to Grab College Students' Attention
The college student population is a fantastic, diverse group with specific needs and wants. Marketing to college students can be hard as you compete for their attention with their school duties and responsibilities.
The Changing Face of the Fashion Industry is on YouTube
ALM (or aLine Media) is a new media first PR firm that is looking at social media celebrities to be the fashion spokeswomen of tomorrow.
From Awareness to Advocacy: How Text100 Leads Audiences on a Journey
This week, we heard from Jeremy Woolf, Senior Vice President and Global Digital/Social Media Lead at Text100 who came in at #16 on our list of the top PR firms on social media this year.
Interview with Natasha Koifman of NKPR
As social media has become an increasingly important part of public relations, most of the best firms out there have learned to adjust. NKPR is no exception, and that's probably why they landed at number 15 on our list of the top PR firms on social media this year.
How One "Familia" at República Sets Them Apart
This week, we got the chance to hear more from the 20th most popular PR firm on social media, República. Like many of the top firms on our list, you'll see that they emphasize an individualized approach, and work to develop lasting relationships with their clients.
Audible Treats: Social Media Music for Your Ears
Photo by Alexander Richter, used with permission from Audible Treats The music industry has embraced social media more than almost any other, so it should come as no surprise that Audible Treats has a worthy presence on social media.
No Two Campaigns are Alike: rbb Public Relations and Social Media
With the #19 spot on our list of the top PR firms on social media, we were excited to hear what rbb Public Relations could tell us about how they find success through social media campaigns.
Learning from BLAZE PR's Social Media Approach
After publishing our annual list of the most popular public relations firms on social media last month, we decided to follow up with some of the companies on the list to find out more about how they manage social media campaigns for their clients.
Top 25 Public Relations Firms on Social Media in 2013
Public relations is a quickly changing field, and little in technology has had as much impact on the industry as social media has.


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"[A] simple but pleasing story with elegantly decorative paintings." Kirkus Reviews
"An excellent read-aloud book. . .A worthy addition to the multicultural collection." Booklist
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Although unable to speak or hear, lovely Lotus learns to perform the intricate story dances of the Cambodian court ballet.
Although unable to speak or hear, lovely Lotus learns to perform the intricate story dances of the Cambodian court ballet.
"[A] simple but pleasing story with elegantly decorative paintings." Kirkus Reviews
"An excellent read-aloud book. . .A worthy addition to the multicultural collection." Booklist
Long ago in Kampuchea, a man and a woman lived on the edge of a lake. A daughter was born to them. She was beautiful, with a face as round as the moon and eyes as bright as the stars.
The father and mother named her Lotus, like the blossoms which covered the lake. They were very happy with their baby, for she was as good as she was lovely.
Years went by, but Lotus was as silent as on the day she was born. When she was sad tears would fall from her eyes, and when she was happy smiles would light her face.
Her father and mother knew that Lotus could not hear. She could not learn to speak. They prayed to the gods, hoping they would take this misfortune away, and cherished their daughter even more.
One day, the mother and father pointed to the blossoms on the lake and to Lotus. Then the mother put her palms together with her fingers bent, forming a flower. Lotus understood. She copied her mother's gesture and so learned to name herself with her hands.
Lotus grew lovelier each day. She liked to weave baskets out of the tall grasses which grew around the lake and to swim with the turtles while her father fished. But Lotus was happiest when she walked among the herons, cranes, and white egrets, joining them in their graceful steps.
Yet Lotus would often sit by herself, lonely and sad. She wanted so much to play with the other children. But if she motioned to them, they pretended not to see. If she pulled their arms to get their attention, they ran away.
Her father and mother saw her unhappiness, but they did not know how to help her. They hoped for a sign from the gods.
Finally, they decided to go to the temple in the city. The mother put wild rice and lotus flowers in a basket as offerings; the father carried his precious daughter on his shoulders. They walked through many fields and villages, and over many canals.
When they reached the city, they hurried to the temple. Inside, the father and mother heard drums and cymbals. Lotus felt the vibrations. Then two lines of dancers appeared.
Elbows high and knees bent, Lotus imitated their movements. Long after the dancers had gone, the little girl danced. Her father and mother looked at each other. It was the sign they had hoped for.
They went to the palace. There, the queen noticed the lovely little girl and whispered to the king.
"Speak," the king said, pointing to Lotus.
"Our daughter does not speak or hear," her father said. "But she would learn to dance."
The mother motioned to her young daughter. Lotus began to dance the way she knew best, like the herons, cranes, and white egrets. The king and queen watched with delight.
"She is a most beautiful child," said the queen.
"She will learn to dance," said the king.
Excerpted from Silent Lotus by Jeanne M. Lee. Copyright © 1991 Jeanne M. Lee. Excerpted by permission of Farrar, Straus and Giroux.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.
Jeanne M. Lee is the author and illustrator of many books, including The Song of Mu Lan and I Once Was a Monkey: Stories Buddha Told. She lives in Massachusetts.
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I think this is the most perfect book for us. I found this book in the library when I was pregnant with her. I read the book to my son and he said,'Is that Baby Lotus?' My husband and I always wanted to have a daughter who would become a traditional dancer. This is a very sweet book that teaches children that they have many gifts to share with the world.


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Mayes already boasts a pair of offers, from Washington State and Idaho and several more schools have been showing interest in the 6-3, 218-pounder.
"Things have really started to pick up for me," said Mayes. "UCLA has started sending me some stuff, I just got a handwritten letter from them. Northwestern has really been picking up the pace, and they want me to get out there in April and I went on an unofficial visit to Oregon the other week and that went really well. They were talking about sending a coach out to watch me at my school for spring practice in May, and they've been sending me handwritten letters for a while. I'm also hearing from Oregon State quite a bit and will be going to their Spring practices."
Idaho was the first school to offer Mayes, but Washington State has made the biggest impression so far. And the Cougars have a longstanding relationship with the Mayes family, as his father, Reuben, is a Washington State legend.
"The pressure is definitely there to go there, but it's a school I'd definitely like to go to," said Mayes. "I grew up there since I was five, before I moved to Eugene, and the town I really like and I'd love to go back there and play. The pressure to play there has crossed my mind, but I'm not worried about it."
Reuben Mayes is one of the greatest players in Cougar history, a recent inductee into the College Football Hall of Fame and a former All-Pro with the New Orleans Saints. He carved out his career on the offensive side of the ball, but Logan wants to play on the other side.
"I'm looking to play outside linebacker next year, as a pass rush type, not necessarily with my hand down, but out there on the edge, getting after the quarterback like DeMarcus Ware," said Mayes.
Mayes was one of the top performers at the Badger/New Level 7on7 in Las Vegas earlier this month and plans to head to a few more camps in the spring and summer.
"I'll be going to Northwestern, Oregon and Oregon State in the spring and I'll be going to UCLA in the summer," said Mayes.
As a 2009 junior at Marist, Mayes had 66 tackles and 11 sacks. He helped Marist to the 4A State Championship, his best game in the playoffs, recording seven tackles and 2.5 sacks against Central.
Academically, he's in solid shape with a 3.7 GPA and a 24 on the ACT. He's taking two AP classes and two Honors classes.


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A special thanks to Alina Kulesh for all her exhausting work in serving to creating the brand new web site. Nonetheless, events to a dispute must take into account that any further extension of the period for arbitration proceedings beyond the above-referred six months requires consent of the parties as per Article forty five of the Omani Arbitration Legislation. Cercone was offended concerning the attention the law school has acquired since the results had been publicized Sept. Regulation schools vie to land jobs for their graduates, but that's bush league competition: We solely have to fret about jobs for one 12 months, we are able to create low-paid jobs of our own, and we are able to play games with the numbers. Against each interpretations, which truly converge in a few of their basic assumptions, I want to recommend that the law does not give us formal equality.
So as to keep professionalism, the apply of regulation is often overseen by either a government or impartial regulating body resembling a bar affiliation , bar council or law society Fashionable lawyers obtain distinct professional identity by means of specified authorized procedures (e.g. successfully passing a qualifying examination), are required by law to have a special qualification (a authorized education earning the scholar a Bachelor of Laws , a Bachelor of Civil Legislation , or a Juris Physician degree.
We don't find out what this monster is actually capable until the episode's surprising conclusion… the capturing of an SVU detective. Open carry … Read More


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Carolina probably does not have the designated zone-buster--the guy you can always count on to make 3 or 4 three-pointers each game--this year. There's no Rashad McCants standing around the arc keeping opposing defenses honest. The Tar Heels will try to compensate for that by employing a three-pointer-by-committee strategy. (Tar Heel Blue)
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