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In a world tearing itself apart, there are people holding it together with heartwarming initiatives. The hockey initiation program by the Gloucester Centre Minor Hockey Association is one such powerful ray of hope. Syrian refugee children take to the ice to learn Canada's national winter sport. Armed with their hockey sticks and an ear-to-ear smile, […]Read more
For the fresh crop of Canadian citizens, there's an all access pass to the country's rich harvest. Valid for a year after the citizenship ceremony, the Cultural Access Pass (CAP) provides free or entry at a discounted rate to over 1200 cultural attractions such as museums, art galleries and science centres spread across the country. […]Read more
CultureLink Settlement and Community Services along with Ryerson University is filling the airwaves with information, music and news pertinent to immigrants. They do this through the community radio program, New Canadian Life. It's a show run by immigrants from different walks of life. Some are refugees. Some have come in search of jobs. Some are […]Read more
M-Bridge Culture Integration Society for Professionals is a proud PINs association run by internationally educated professionals (IEPs). M-Bridge's Executive Director, Sophie Duan talks about her experience with the PINs program. M-Bridge was formed in 2008 to help professional immigrants to integrate into Canadian workplace and society through educational services. As a volunteer-run association, we were constantly […]Read more
YMCA of Greater Toronto has launched Next Stop Canada, a pre-arrival settlement service designed for overseas immigrants whose permanent residence application is in its final stages. An online platform, it delivers settlement information, orientation and referral services, and helps participants prepare for their new life in Canada, through its two programs; The Electronic Newcomer Information […]Read more
The Peoples Church was founded in 1928 in Toronto. Appreciating the diversity of nationalities represented at the church and in Toronto, the Peoples Church began the Newcomers Network in 2013 to help immigrants integrate and adjust to life in Toronto. The Newcomers Network offers a mentoring program and a language café, where new immigrants can find community services, […]Read more
Are you a newcomer looking to explore Toronto, know the city and the people? Try Bike Host, a newcomer mentoring program run by CultureLink, a settlement agency and Cycle Toronto, a membership-based organization that promotes cycling. Bike Host focuses on multiple objectives in one ride. It helps newcomers explore the city, know the bike paths […]Read more
For newcomers arriving in Toronto for the first time, the city's expanse can pose a challenge in terms of its transit. But once you understand how it works, identify the hubs, it becomes very easy to navigate within the Greater Toronto Area (GTA). And now there is UP Express, the latest addition to GTA's fast […]Read more
Winter is almost here. The season opens doors to several winter sports that newcomers may not have experienced back home. Skating is one such activity. And if you are envying other skaters and wondering if you will ever be able to learn skating, don't loose heart and look no more. Harbourfront Centre in Toronto has […]Read more
Center for Community Learning and Development's Immigrant Women Integration Program (IWIP) aims to provide a leadership development opportunity for immigrant women, to help them prepare for work or for volunteering in the social service and community-based sector. The objective of IWIP is to help participants develop organizational and analytical skills, gain understanding of organizational structures and participate directly in local […]Read more


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FICTION, GENERAL* Author: DORothy EDEN Title: THE SALAMANCA DRUM Product ID: 019571
ISBN: 069810823XBinding: Hard CoverEdition: Book Club (BCE/BOMC)Publisher: COWARD, MCCANN AND GEOGHEGAN INCPlace of Publication: New York, NY, U.S.A.Date Published: 1977Signature: Book Condition: Very Good-Jacket Condition: GoodBook Size:
Type: USED All orders shipped media mail the following working day..249 PAGES.
Keywords: GENERAL FICTION
We offer a exchange or refund policy if the item you purchased does not meet your expectations in any way. Please return within 7 Days.

subset: commoncrawl


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Welcome to Reeds.ie
Reeds.ie is an Irish owned and run online fishing tackle retailer. Based in the Midlands, we distribute fishing tackle nationwide.
We specialise in pike and predator fishing tackle and cater for all disciplines - be it the winter dead-baiter, the summer lure angler or the all-rounder. We believe in and promote the safe handling and release of all fish and we stock the appropriate tools and equipment to aid pike anglers and anglers in general to quickly and safely deal with their catch.
We pride ourselves on providing excellent service and ensuring our customers get the service we'd hope to receive ourselves. We're always happy to answer any questions or queries and promise we won't keep you waiting too long, even if we are out fishing!
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The issue of the services not providing proper funding for their morale, welfare and recreation programs hasn't been resolved and likely will become the new administration's problem, said a defense official who has been pushing the services for details on why they haven't met requirements.
"I am determined to have some kind of proposal on moving forward before I leave here," Todd Weiler, assistant defense secretary for manpower and reserve affairs, told Military Times on Thursday. "It will be in the form of a recommendation for the new administration."Weiler had expressed concern to the services about their failure to fully fund their MWR programs, with each branch falling short of DoD budget requirements. The services must pay for a certain percentage of some MWR programs using taxpayer money, a rule that would guarantee a minimum level of MWR support and prevent service members and their families from bearing costs that should be borne with taxpayer funding, Weiler wrote in memos sent in September to service officials.
"These standards are not optional and are not subject to Military Department waiver," he wrote.
Weiler also asked Army Secretary Eric Fanning to delay plans for a $105 million cut to the service's MWR funds, or about 23 percent of the MWR budget. Fanning put a hold on the cuts until Army officials have completed a thorough analysis.
"I want to be thoughtful in the way we do things," Weiler said in an interview. "I just think there are better ways to do business, be more efficient, so that we can deliver the services to the people that need them."
In the family support area, there are probably some ways to be more efficient, he said. "Everybody has a responsibility to do their part. That's one of the benefits of having someone who's run a business. I can bring some capabilities to make recommendations on how we can either keep or improve the level of services at the funding levels we're at, by being more efficient."
This is a different all-volunteer force than it was in the 1970s and 1980s, he said, and what's needed at one installation may be less important at another, suggesting the Pentagon avoid a "cookie-cutter approach."
"What I can do is find efficiencies – how to do business better and make sure the money that's intended to go to local folks to support them gets to them," Weiler said.
Karen Jowers covers military families, quality of life and consumer issues for Military Times. She can be reached at email@example.com .
Karen Jowers covers military families, quality of life and consumer issues for Military Times. She can be reached at firstname.lastname@example.com .


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Dr. Brenda Hampton MD Patient Reviews
- Family Medicine Garland, TX
Overall Rating
44 Patient Reviews
- Wait Time 13.1 minutes
- Easy Appointments
- Promptness
- Friendly Staff
- Fair and Accurate Diagnosis
- Bedside Manner
- Spends Time With Patients
- Appropriate Followup
Showing 1 - 12 reviews
5.0 of 5
February 2nd, 2015
Best Doc Yet!
Great Doctor, Very Impressive!
2.0 of 5
December 31st, 2013
Good Dr AWFUL STAFF
Dr Hampton is great, her staff is awful and down right rude.
5.0 of 5
August 24th, 2013
"The Best"
I love Dr. Hampton, she is very personal. The first time i met her it was like i have been knowing her forever. She listen to my concerns. Everyone that i have referred to her, has called me and said "love her." She very conversational and i just like everything about her, very good for the family. I have been going to her over five years off and on. Try her you will love her too!!
5.0 of 5
July 24th, 2013
Many Thanks
You are a patient and understanding Dr. the time you take with your patients is very much appreciated. You do not make any feel that you are just a number waiting for a payment. You always have time and take time to hear all that anyone has to say questions or otherwise. We will always be gratefull for the oppertunity to have you as our Dr. May you be blessed with a great and continued practice.
5.0 of 5
September 7th, 2012
Dr.Hampton is the BEST
I have used Dr. Hampton for over 10 years. She is the BEST Dr. ever!! I have referred many to use Dr. Hampton and all of them were very happy that I did.
1.0 of 5
July 26th, 2012
Thank you so much for you kindness in the office Dr. Hampton. Although when trying to speak with you directly after the appointemnt I found myself almost disgusted. You have no personal voicemail. When your staff pre-authorized my insurance and then the insurance declined payment I was contacted by a gentleman named George in your office. He stated if I did not pay the full amount I would be sent to collections. Along with the $1000 labs bill I received, you are charging me $275. I know beyond reasonable doubt insurance would not pay this amount. When asking George if he heard back from my insurance company to negotiate, he cut me off saying thats not how it works. They either pay it or the don't. I had no option to ask him why I am being charged more as a customer than insurance would pay? I am so horrified by my experience I have contacted a mal-practice lawyer to try and help me. Hopefully, you will see this message, since you do not have a voicemail or a way to leave you messages, in effort to speak with you about your employee George and other extremly curt employees. As the owner/operatior of a business, I would hope you would.
5.0 of 5
April 2nd, 2012
One of the best
Dr Hampton is very personable and makes you feel at ease while talking to her. The staff members are all so courteous. I call once in a while for an acute visit and they will typically walk you in unless their schedule is completely full. My calls are returned promptly as well. I am very satisfied with Dr Hampton and her staff members.
1.0 of 5
November 28th, 2011
Receptionist Lydia extremely RUDE
I was referred by another patient. When I called to get an appointment LYDIA was very rude and nasty. I'm thinking she didn't have her morning coffee. But I will make sure I tell potential patients how rude this office is
5.0 of 5
November 21st, 2011
Dr Hampton takes time to get to know her patients. She is very personable which makes you feel comfortable about telling her about all your aches and pains. I recommended her to my family and they came home telling me how right I was about how GREAT she is!
5.0 of 5
February 17th, 2011
Awesome Family Doctor
Dr. Hampton has taken care of our entire family for the last 8 years. We could not ask for a better doctor and even though we have had to relocate to West Virginia, we refuse to loose her as our family doctor. We travel back and forth for checkups. She genuinely cares about each of her patients and if you have a specific health issue, she will study everything she can find to ensure that she is giving you the absolute best care possible. Everyone I know that goes to her feels she is a blessing in their lives. I know I feel that way.
5.0 of 5
June 2nd, 2010
Jessica Ramirez
Dr Hampton listens and truely cares about her patients. I would recommend her to everyone!
5.0 of 5
February 21st, 2017
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How First Niagara got arena naming rights
While First Niagara Financial Group Inc. was completing talks with HSBC Bank USA N.A. to acquire 195 retail branches, officials broached a different but related topic.
What about the naming rights to HSBC Arena, home of the Buffalo Sabres? Would HSBC Bank be willing to allow First Niagara to acquire those rights in addition to the branches?
"Put it on us," said John Koelmel, First Niagara president and chief executive officer. "The opportunity was there to ask the question. It was (HSBC's) asset. But it was the right time and right place for them to allow this to happen and it was the right time and right place for us do that."
Nearly one month after announcing the $1 billion deal to purchase HSBC branches in New York state and Connecticut, First Niagara has acquired the naming rights to the downtown Buffalo sports and entertainment arena. As of Aug. 25, the venue's name switched from HSBC Arena to First Niagara Center. The deal gives First Niagara:
• Exclusive exterior facility naming rights
• Exclusive banking presence within the facility
• Exclusive onsite ATM presence throughout the arena
• Television and other "value-added" promotional benefits
Terms of the new 15-year naming-rights agreement remain undisclosed. The amount of money that First Niagara has committed to the deal will eventually become public because First Niagara, as a public company, must disclose the information.
The bank's marketing and advertising expenses will likely increase because of the deal. First Niagara spent $3.8 million in that category during the second quarter of 2011, which ended June 30. That's down from $7.7 million spent on marketing and advertising during the same quarter of 2010.
Meanwhile, officials from the NHL franchise say they are pleased with the way events have transpired.
"I'd be lying if I didn't say I was excited," Sabres president Ted Black said. "An opportunity like this doesn't come along very often, so we were lucky to take advantage of the opportunity when it did come."
The task of changing signage from HSBC to First Niagara is slated to begin immediately, officials said. The most significant part of that involves removing the "massive" HSBC lettering from the exterior of the building, Black said. He anticipates the signage will be switched out before the Sabres' Oct. 14 game against the Carolina Hurricanes.
HSBC, meanwhile, plans to maintain its arena box. Paul Cronin, HSBC's regional president for commercial banking in Upstate New York, was on hand for the Aug. 25 announcement. He said the bank brings customers to watch Sabres home games and will continue to have a presence, albeit through commercial banking only, in the region.
This isn't the first time that First Niagara has secured naming rights. Soon after it expanded into the Pittsburgh area, it bought rights to the former Post-Gazette Pavilion, an amphitheater in Burgettstown, Pa. It is currently a presenting sponsor of the New Haven Open at Yale, a women's tennis event in Connecticut. First Niagara closed its $1.5 billion acquisition of New Haven-based NewAlliance Bancshares Inc. earlier this year.


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Training for the Legal Profession
If you are looking to take your next steps towards qualifying as a lawyer, Edinburgh Law School's Edinburgh Centre for Professional Legal Studies (ECPLS) has been delivering the professional diploma required to practise law in Scotland for more than 30 years.
We are accredited by The Law Society of Scotland to deliver Professional Education and Training Stage 1 (PEAT 1) and also, Trainee CPD required in Professional Education and Training Stage 2 (PEAT 2), as well as general continuing professional development programmes for solicitors and advocates.
Find out more about our Diploma in Professional Legal Practice.
- Edinburgh Centre for Professional Legal Studies
- Diploma in Professional Legal Practice
- Free Legal Advice Centre
- Career Prospects
Contact Information
Contact Details
Edinburgh Centre for
Phone: 0131 651 4254


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This is a great funnel! It does the job well at it's affordable price. Would highly recommend it!!
BikeMaster Funnel With Flexible Fill Hose
BikeMaster Funnel With Flexible Fill Hose
$12.56 $13.95
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4.50 5 1
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1 year 11 months ago San Diego, CA, USA
BikeMaster Funnel
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Q: Will this work on the crf110f when changing oil? Thanks?
2 years 6 months ago
MotoSport Staff Expert2 years 6 months ago
A: Yes, but the BikeMaster Funnel With Flexible Hose And Tube has a Narrower tube which may fit better on the CRF110F. http://www.motosport.com/bikemaster-funnel-with-flexible-hose-and-tube
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Blessed Holy Nativity - Yeldho
Expand Messages
- May each of you have a blessed Holy Nativity - Yeldho
Your prayers and support are truly appreciated - please continue to pray for our efforts. Visit our website: www.maruroopa.blogspot.com
A special e-card is posted for you at
http://maruroopa.blogspot.com/2010/12/christ-is-born-let-us-glorify-him.html It is the Nativity from a 13th Century Ethiopian illuminated manuscript, one of the oldest in existence.
Also, posted - the "Two Christmas Days" article
And a very good advent article written by long time mission member, Geoffrey Gyrisco. "One Man's Advent Reflection" was originally sent to
Christ is born! Let us Glorify Him!
We hope to see you during this holy time. If not send your prayer requests that we may remember you in our prayers. You can also send requests and donations to Holy Transfiguration, P.O. Box 5207, Madison, WI USA 53705
Holy Transfiguration Orthodox Mission Chapel
621 N. Sherman Avenue, Suite B3, Madison, Wisconsin
608.242.4244 ~ transfiguration@...
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|Home | About | Journals | Submit | Contact Us | Français
S. Cheon, Department of Statistics, Sejong Campus, RM 407B, Korea University, Phone: 041-860-1711, rk.ca.aerok@noehcs
D. Havaleshko. Department of Molecular Physiology, University of Virginia, P.O. Box 800422, Charlottesville, VA 22908. Phone: (434) 982-3356, FAX: (434) 243-6937, ude.ainigriv@v4hmd
H. Jeong, Department of Urology, Seoul National University Boramae Hospital. Phone: 82-2-870-2392, rk.oc.mrb@hjrd
F. Cheng, Department of Biophysics, University of Virginia, P.O. Box 800717, Charlottesville, VA 22908. Phone: (434) 982-2506, FAX: (434) 924-8437, ude.ainigriv@b8cf
D. Theodorescu, Department of Urology, Box 422, University of Virginia Health Sciences Center, Charlottesville, VA 22908. Phone: (434) 924-0042, FAX: (434) 982-3652, ude.ainigriv@d9td
J. K. Lee. Department of Public Health Sciences, Box 800717, University of Virginia Health Sciences Center, Charlottesville, VA 22908. Phone: (434) 982-1033, FAX: (434) 924-8437, ude.ainigriv@n7lkj
Conventional development of multi-gene expression models (GEMs) predicting therapeutic response of cancer patients are based on analysis of patients treated with specific regimens, which limits generalization to different or novel drug combinations. We overcome this limitation by developing GEMs based on in vitro drug sensitivities and microarray analyses of the NCI-60 cancer cell line panel. These GEMs were evaluated in blind fashion as predictors of tumor response and/or patient survival in seven independent cohorts of patients with breast (N=275), bladder (N=59), and ovarian (N=143) cancer treated with multi-agent chemotherapy, of which 233 patients were from prospectively-enrolled clinical trials. In all studies, GEMs effectively stratified tumor response and patient survival independent of established clinical and pathologic tumor variables. In bladder cancer patients treated with neoadjuvant MVAC (Methotrexate, Vinblastine, Doxorubicin, Cisplatin), the 3-year overall survival for those with favorable GEM scores was 81% vs. 33% for those with less favorable scores (p=0.002). GEMs for breast cancer patients treated with FAC (Fluorouracil, Doxorubicin, Cyclophosphamide) and ovarian cancer patients treated with platinum-containing regimens also stratified patient survival (5-year overall survival 100% vs. 74% (p=0.05) and 3-year overall survival 68% vs. 43% (p=0.008), respectively. Importantly, clinical prediction using our in vitro GEM was superior to that of conventionally-derived GEMs. We demonstrate a facile yet effective approach to GEM derivation that identifies patients most likely to benefit from selected multi-agent therapy. Use of such in vitro-based GEMs may provide a robust and generalizable approach to personalized cancer therapy.
Most cancer patients with advanced tumors undergo combination pharmacotherapy. A challenge in treating these patients is predicting which individuals will respond to a specific therapy. Recent studies have demonstrated the potential that tumor response to chemotherapeutics can be predicted using multivariate Gene Expression-based Models (GEMs).(1, 2) Such GEMs are developed using a training microarray set from tumors of human patients with known clinical responses to the drug(s), allowing selection of optimal marker genes and respective expression levels to construct such models.(3, 4) These are then evaluated in separate patient cohorts to determine their predictive ability. While validation is straightforward, formulation of such GEMs is lengthy, expensive, and requires human tumor tissue from patients treated with the specific drug regimen for which the GEM prediction is desired. In addition, this approach does not permit a priori prediction of responses to single or combination therapy that has never been clinically used, limiting the pairing of novel agents to their optimal disease types, thus hindering identification of novel applications of established agents.
To overcome these limitations, two recent studies derived GEMs based on biomarkers of in vitro drug sensitivity of cancer cell lines in the NCI-60 panel (5, 6) and demonstrated that such GEMs can predict the clinical outcome in patients who received systemic therapy. While promising, these reports did not provide validation of unaltered GEMs on multiple independent patient data sets. If such GEMs can maintain a robust prediction in this setting, this approach has the potential to revolutionize personalized cancer therapy and drug development since forecasting the clinical effectiveness of a compound could be undertaken very early in the drug development lifecycle.(7)
Here, we develop and apply GEMs derived from in vitro data and demonstrate the ability of these to predict clinical responses to combination pharmacotherapy regimens in 477 patients with three common cancer types reported in retrospective studies or prospective clinical trials. Importantly, the patient cohorts examined came from ethnically and geographically distinct regions.
In vitro drug activity and microarray data of the NCI-60 cancer cell panel were previously described elsewhere.(6) Microarray gene expression data without associated treatment or clinical outcome information from three human tumor sample cohorts were used for GEM development including bladder cancer (N=89) (8), ovarian cancer (N=99) (9), and breast cancer (N=251).(10) These comprise the Training set (Figure 1). For GEM evaluation, through our own efforts and collaborations, we acquired and used seven independent Test sets in which data from microarray gene expression could be linked to clinical outcome. Test set studies included two bladder cancer (N=59), two ovarian cancer (N=143), and three breast cancer (N=275) sets of patients treated with multi-agent pharmacotherapy (Table 1). Of these, 233 patients were prospectively enrolled in clinical trials (BR-TX and BR-Ger). Training and test microarray data sets are publicly available or were obtained directly from the original authors. When survival or tumor response data (complete (CR), partial (PR), or down-grade/stage) were not publicly available, this information was obtained from the original investigators. Note that these test set studies included geographically and ethnically diverse populations with various tumor stages and tumor sampling methodologies and did not share any patients or clinical locations with the sets used for GEM development (Table 1 & Figure 1).
The COXEN algorithm (6), originally demonstrated to predict single-agent chemosensitivity for a cell line panel and small breast cancer sets, was expanded and refined to derive GEMs and subsequent GEM-predicted chemosensitivity probabilities (named "GEM Scores") in patients with bladder, ovarian, and breast cancer (Figure 1; Supplementary Methods). Briefly, each microarray data set was first standardized within each gene for consistent GEM development and evaluation. Chemosensitivity biomarkers for each compound were then identified in the NCI-60 microarray dataset by comparing each gene's differential expression between the sensitive and resistant cells for each compound. These biomarkers were next triaged based on the COXEN coefficient which represents the degree of concordance of expression between the NCI-60 set and one of three cancer patient microarray data sets used for development---BR-251, BL-89, or OV-99.(6) This resulted in a panel of 15~95 gene probe sets per compound that were used for the GEM training of statistical multivariate classification modeling between the NCI-60 sensitive and resistant cell lines for that compound. Individual compound GEMs were then combined to generate the prediction model for relevant combination pharmacotherapy, assuming the modes of action of individual compounds in combination chemotherapy were independent. Importantly, this model development and training did not use any clinical information or microarray data from the test sets used for GEM evaluation, thus maintaining strict independence between training and test data sets.(11)
We compared the GEM scores between clinical responders and non-responders as reported in five studies for which tumor response data after pharmacotherapy was available (Figure 1). The significance of this score difference was evaluated using the two-sample t-test between the responder and non-responder patient groups. In the two studies for which tumor response data were not available, OV-GA and BR-Tai, we compared GEM scores between actual surviving and deceased patients---the only available information of patient outcomes in these two studies, using the absolute call of patients' survival as a surrogate metric for tumor response. Patient survival would have depended not only on chemotherapeutic response but also on many other clinical factors but we simply tested whether the survivor group was more enriched with predicted responders to chemotherapy. Once a GEM was derived for a particular agent or combination of agents in a cancer type, it was used without any alteration in all subsequent evaluations. Where information on patient survival time was available, we performed Kaplan-Meier (KM) analyses on five cohorts stratified by the GEM scores from the analyses of tumor response. In order to classify predicted responders from predicted non-responders a priori, a Receiver Operating Characteristic (ROC) curve was plotted (Figure S1). The optimal cutoff on the ROC curve was determined by maximizing the so-called Youden index (=sensitivity+specificity−1), at which sensitivity, specificity, positive predictive value, (PPV), and negative predictive value (NPV) were evaluated for each combination GEM in stratifying patients' clinical response.(12)
We examined whether our multi-gene expression-based GEM scores are correlated with conventional clinical parameter information such tumor stage, grade, well-known marker types e.g., ER, PR, Her2 in breast cancer . We first calculated simple univariate (rank-based Spearman or binary) correlations between the GEM scores and each of clinical parameters. Next, in order to see the relationship between GEM scores and combined clinical information, we measured the correlation between the GEM scores and a published clinical variable-based breast cancer nomogram that predicts pCR after preoperative chemotherapy based on patient age, tumor size, ER-status, tumor grade and the type and number of chemotherapy treatments.(13)
Using prospectively-predicted and outcome-blinded GEM scores the single-drug GEMs of adriamycin and cisplatin provided scores of responder patients which were significantly higher than those of non-responders (adriamycin GEM score with two-sample t-test p-value=0.049 and 0.061 and cisplatin GEM score with p-value=0.007 and 0.012) both in the neoadjuvant (BL-Jap) and advanced tumor (BL-Den) studies (Table 2). The GEM score for methotrexate and vinblastine was significantly different only in the BL-Jap study (p-value<0.001 and =0.002). The single drug GEMs of methotrexate, vinblastine, adriamycin, and cisplatin were then combined to formulate the combination GEM for MVAC response. Using this combination GEM, a significant difference in scores was observed between responders and non-responders in both studies (p-value=0.002 and 0.033). This combination GEM provided sensitivity 83%, specificity 64%, PPV 71%, and NPV 78% at the cutoff value maximizing the Youden index; the overall significance of ROC curve against random classification was also extremely significant (Wilcoxen test p-value<0.001, Supplementary Figure S1). Note again that each of these GEMs was simultaneously applied and evaluated unaltered on the Japan (BL-Jap) and Europe (BL-Den) sets. We further examined whether the GEM scores were correlated or overlapped with the information from conventional clinical parameters of patients. Using a univariate analysis of rank-based correlation on the BL-Jap cohort, we found that the GEM for MVAC response was independent of available clinical parameters such as tumor stage, grade, age, or gender (Spearman correlation −0.14 ~ 0.07). We also found the GEM score to be the only significant predictor of MVAC response on this cohort by a multivariate analysis that was performed together with the GEM score and the above clinical and tumor pathological variables (logistic regression GEM p-value=0.03; Table 3).(14) The BL-Den study was not large enough for a multivariate analysis.
In ovarian cancer, the unaltered carboplatin GEM also showed consistently significant results for patient response to pharmacotherapy in the OV-NC study (p-value=0.034) and for absolute patient survival in the OV-GA study (p-value=0.047) (Table 2). In the OV-GA study, patients received carboplatin and Taxol (paclitaxel) and a large proportion of patients in the OV-NC study were also reported to receive Taxol. We thus tested the ability of GEM prediction for this drug to stratify the outcome in the two ovarian studies. The scores of the Taxol GEM, in fact, correlated well with the clinical response in the OV-NC study (p-value=0.003) and with absolute patient survival in the OV-GA (p-value=0.025) study. When the carboplatin and Taxol (CT) combination GEM was applied, the differences in GEM scores between responders and non-responders in OV-NC was highly significant (p-value=0.007). Moreover, the same combination GEM significantly segregated scores between patients who survived and deceased patients in the OV-GA study (p-value=0.008). This combination GEM provided sensitivity 77%, specificity 56%, PPV 71%, and NPV 78% for the OV-NC cohort at the Youden cutoff value; the overall ROC curve was also extremely significant (p-value<0.001, Supplementary Figure S1). Together, results in ovarian cancer also showed that the identical GEMs of individual agents and the combination were successful in stratifying not only the measured tumor response in the OV-NC study but also absolute patient survival (survivor vs. deceased) in the OV-GA study. In the OV-NC study, for which other clinical parameters were available, the CT combination GEM score was found to be independent of other clinical and pathological variables such as tumor grade and stage (Spearman correlation −0.15, 0.04) and the only significant predictor of tumor response to pharmacotherapy (logistic regression GEM p-value=0.022; Table 3).
The response to pharmacotherapy of patients in the neoadjuvant breast cancer study BR-TX and survival of patients entered on the adjuvant BR-Tai breast cancer study also correlated to our GEM scores (Table 2). For example, the identical single-drug GEMs for adriamycin and cyclophosphamide were consistently different in tumor response to pharmacotherapy in the BR-TX study (two-sample t-test p-value=0.019 and 0.064) and in absolute patient survival in the BR-Tai study (p-value=0.002 and 0.052). The GEM of 5-FU was significantly different only in BR-Tai (p-value=0.024). Nevertheless, the combination prediction model based on the three single-drug GEMs of 5-FU, adriamycin, and cyclophosphamide - compounds used in both studies - was significantly associated with patient chemotherapeutic responses in BR-TX (p-value=0.021) and survival status in BR-Tai (p-value=0.033). This combination GEM provided sensitivity 71%, specificity 53%, PPV 32%, and NPV 85% at the Youden cutoff value; the overall ROC curve was highly significant (p-value=0.007, Figure S1). For the neoadjuvant BR-Ger breast cancer study, all the single-drug GEMs of gemcitabine, epirubicin, and docetaxel (p-value=0.014, 0.055, and 0.044) and the combination prediction model based on the three single-drug GEMs were significantly different between responders and non-responders to pharmacotherapy (p-value=0.003) (Table 2). In the BR-TX study, the only breast cancer trial both with patients' chemotherapeutic response and other clinical variable information, the GEM for TFAC response was independent from other clinical and pathological parameters (Spearman correlation −0.07 ~ 0.13). We also compared our GEM scores with a previously-published nomogram prediction of chemotherapeutic response based on the clinical characteristics of the patient and tumor.(13) We found that the Taxol GEM scores are weakly correlated with the nomogram (Pearson correlation = 0.24) and the FAC GEM scores are not correlated (Pearson correlation = 0.07). In multivariate prediction modeling, both ER status and GEM score were found to be significant predictors of tumor response in this cohort, implying potentially improved predictability by combining GEM and clinical parameter information (logistic regression p-value <0.001, =0.032; Table 3).
Unaltered GEMs evaluated above were then examined for their ability to stratify actuarial patient survival. Using the selected score cutoffs for the combination GEMs, patient survival time was stratified in the Kaplan-Meier analysis for all five studies with patient survival time information across the three tumor types. With the stratification by the combination GEM of MVAC in bladder cancer, the 3-year overall survival rates were 81% for predicted responders compared to 33% for predicted non-responders on the BL-Jap study (log-rank test p-value=0.002), and 61% vs. 16% on the BL-Den study (p-value=0.015), (Figure 2A). In ovarian cancer, the combination GEM of carboplatin and Taxol also effectively stratified patient survival time in both OV-NC (log-rank test p-value=0.008) and OV-GA (p-value=0.028) studies (Figure 2B). In this analysis, patient stratification by the GEM scores provided a difference in 3-year overall survival of 68% vs. 43% in OV-NC and >95% vs. 23% in OV-GA. In breast cancer, based on the combination GEM of FAC, we performed the Kaplan-Meier analysis on the BR-Tai study, the only breast cancer set with patient survival time information. This GEM stratification was also significant (p-value=0.05) with the 5-year overall survival rates ~100% vs. 74% between the predicted responders and predicted non-responders (Figure 2C).
An important advantage of COXEN-based chemosensitivity prediction is efficient development of GEMs for any single drug or combination with observed effects on cell lines in vitro. However, an important question is whether this technique sacrifices predictive performance compared to classical patient sample-trained GEMs that may reflect in vivo activities and/or synergistic effects of certain compounds. We thus compared whether COXEN-derived GEMs were equally effective as previous GEMs developed using a training microarray set from human patients with known clinical responses to the drug(s). For example, in the BL-Jap study, the original authors reported a 14-gene signature GEM, which we call the Takata-GEM, predictive of patients' response to MVAC combination chemotherapy.(15) This Takata-GEM was developed from the initial set of 18 patients and evaluated on an additional set of 27 patients (total 45) from the same center. We compared the performance of the COXEN-based MVAC combination GEM, COXEN-GEM, to Takata-GEM for patients' disease-free survival time stratification. Both GEMs were first evaluated both with the test subset of BL-Jap (N=27) and the whole BL-Jap cohort (N=45). Finally, both GEMs were evaluated for their predictive ability on a third independent set, BL-Den.(16) COXEN-GEM was found to be an effective predictor of patient outcome in the whole BL-Jap set (Figure 3A upper panel) as well as its test subset (Figure 3A lower panel). Takata-GEM was certainly able to stratify patients' outcomes well when applied to the whole BL-Jap cohort (Figure 3B upper panel). However, when this model was used to predict the test subset independent from its GEM training, its statistical significance became considerably weaker (p-value=0.078; Figure 3B lower panel). When applied to the independent BL-Den set, the COXEN-GEM retained its prediction performance (Figure 3C) while the Takata-GEM was unable to stratify the patient outcome in this independent cohort (Figure 3D).
The conceptual framework and the high potential of in vitro drug activity-based GEMs for predicting patient response to chemotherapy has been laid out in previous studies.(6) In this study we demonstrated two major breakthroughs in GEM-based prediction for patients' chemotherapeutic responses: 1) concordant prediction performance of unaltered in vitro-based GEMs on geographically and ethnically diverse cancer patient cohorts in three different cancer types, and 2) simultaneous use of multiple, parallel historical patient data sets for efficient GEM assessment. Together, we believe these provided a highly encouraging possibility in applying such in vitro-based GEMs to guide patients with more effective chemotherapies.
Some recent GEMs initially reported with their superior prediction performance failed to perform well by an independent group's validation.(11) This may be due to the so-called selection bias when such multi-gene predictors were trained both with modeling and applying microarray datasets of numerous candidate genes. Our current study has avoided this pitfall by independently testing multiple geographically- and ethnically-diverse patient sets and by consistently predicting both clinical tumor response and patient survival outcome of 477 patients across three different cancer types. Therefore, we believe the prediction performance of the in vitro-based GEMs here will be highly likely realized in clinical practice even though the statistical power of some of these GEMs may appear to be a bit lower than those reported in other recent studies applied only to a single patient set at a time.(17)
We found that the GEM score was independent of conventional clinical parameters and was always a significant predictor of tumor response to pharmacotherapy even when all other clinical variables were considered together, suggesting that the GEMs are not simply surrogates of standard tumor characteristic variables. Also, GEMs generated by various different training sets that contained distinct stages of bladder cancer successfully stratified patient survival with only a slight decrease in statistical significance whereas the accuracy to distinguish the ability to responders from non-responders was maintained (Supplementary Figure S2). While the assumption of independence of relevant agents was necessary due to our GEM derivation from the single-agent drug activity data of NCI-60, our GEM scores correlated well with clinical responses and survival of diverse patient cohorts of the three cancer types treated with multi-agent pharmacotherapy in this study. This demonstrated that even though our combination GEMs could not capture synergistic drug effects, the main efficacy of combination regimens appeared to be reflected by simple additive effects of single drug GEMs. It is conceivable that future in vitro work on doublet or higher-order drug combinations may help in modifying the algorithm to effectively incorporate drug synergies.(18)
We, however, note that each GEM's reported sensitivity, specificity, NPV, PPV values, or Kaplan-Meier curves here (derived from its ROC curve) showed its optimal performance on the applying particular data set. This does not yet represent validation of each drug GEM's pre-set threshold to call a patient case + (responder) or − (non-responder), but rather shows proof-of-a-concept, illustrating that such GEM scores are informative in stratifying patients' responses to the agent. In order to derive an exact cutoff criterion on a specific GEM assay for clinical use, a standard diagnosis assay platform and procedure should be developed for routine clinical practice, from which a fixed cutoff value can be defined for a target patient population, which, we believe, is quite feasible in the near future.
Generating GEMs using in vitro-based approaches does also have some theoretical and practical limitations. For example, it cannot be used to develop GEMs for agents which do not have any effect on cell lines in vitro. While this requirement is strictly embedded in the design of the approach, the composition of the cell panel may be tailored to the expected cellular and molecular target of the tested agent. For example, while using the NCI-60 panel may not result in an effective generation of a drug response profile for an anti-angiogenic agent that targets endothelial cells, carrying out such an experiment on an endothelial cell panel may provide the necessary data which can be used for GEM development. Similarly, for agents that target the immune system, panels composed of the appropriate cells may permit GEM development. As we have shown above, the critical requirement for the cell panel is to provide effective dose response information for the agent in question rather than be required to be composed of the same histological tumor types as the human tumors whose response to therapy is assessed. Hence, using an endothelial cell panel for an anti-angiogenic agent and generating GEMs for the use of such an agent in bladder cancer, for example, seems to be justified.
This work was supported in part by National Institutes of Health grants T32DK069264 to PDW, R01CA075115 to DT, and R01HL081690 to JKL. We thank Drs. Yusuke Nakamura and Toyomasa Katagiri at the Tokyo University, Dr. Torben F. Ørntoft at the Aarhus University Hospital, Denmark, and Dr. John McDonald at the Ovarian Cancer Institute of the Georgia Tech University who provided us with unpublished patient outcome information. We also thank Drs. Christopher Moskaluk, Christopher Thomas, and Alton Sartor for their insightful comments and suggestions.
Competing interests' statement: None
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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An inclusive congregation affiliated with the Conservative Movement.
Our doors are open to all.
December 16, 2016 By bethmordecai no comments.
Dear Hevreh, My very first day as rabbi of Beth Mordecai, I excitedly penned an email entitled "DAY 1" to share the "first step" in my rabbinic journey at Beth Mordecai. Now, nearly 1700 days since that first email, I write this letter with very different emotions to tell you that the next step in my rabbinic journey will take me in a different direction, and that after June 30, 2017 I will no longer be the rabbi of Beth Mordecai. I can't even begin to consider the impact of all the days I've counted, all of the steps I've taken along my rabbinic journey with you. How can I truly relate the emotions of the times we've laughed together, cried together,[...]
Category : Rabbi Rabbi's Journal Videos Tag : Rabbi Saks
August 15, 2016 By bethmordecai no comments.
Dear Hevreh, Yesterday (Sunday) I had the pleasure of spending the end of Tisha B'av learning Torah with a number of 20s and 30s who live in Highland Park. Many topics were included in this marathon of learning including... how Tisha B'av implores us to feel the pain of historical collective trauma, how we struggle with understanding why bad things happen to seemingly good people, and how our love affair with Jerusalem revolves around lamenting its destruction and hoping for its rebirth (among other topics). The conversation was stimulating, variegated, and incisive because we weren't shy to share our own perspectives - our Unique Torah - and we weren't afraid to listen and be moved by the teachings of[...]
Category : home Rabbi Rabbi's Journal Tag : learning rabbi rabbi's journal synagogue tisha b'av unaffiliated unique torah young people
July 21, 2016 By bethmordecai no comments.
Dear Hevreh, Below you'll find a prayer I wrote in honor of the victims of the Dallas shooting which I'll be reading at a vigil today organized by the Perth Amboy Chaplain Corps. I will be speaking on this prayer (and the sources quoted) during my talk tonight. Shabbat Shalom, Rabbi Ari Saks Adonai Elohei Haruchot L'khol Basar, God, Source of the breath of all flesh (Numbers 27:15) You breathed your spirit into the nostrils of the First Human (Genesis 2:7) Imbuing our earthly bodies with your heavenly spirit (Rashi on Genesis 2:7) A pure spirit (Talmud Masekhet B'rakhot 60b; Birkhot Hashahar) So as long as I breathe, I acknowledge Your Presence (Talmud Masekhet B'rakhot 60b; Birkhot Hashahar) Lord in this moment of hamas, of anger and hostility (Genesis[...]
Category : American Jewish News home Rabbi Rabbi's Journal Tag : #BlackLivesMatter breathe dallas Police prayer rabbi rabbi's journal shooting
July 1, 2016 By bethmordecai no comments.
Dear Hevreh, It's my fault that fireworks are not happening tonight. One of the organizers asked me to pray that rain would not fall tonight, and though I did offer a prayer, it didn't help; the weather forecast is too inclement for the fireworks to happen tonight. They've been rescheduled for tomorrow and I hope the organizer doesn't ask me to offer a prayer for those fireworks - I don't want it to backfire. Before you write me a note saying "to not take your prayers so seriously" or that "you really didn't cause this," just know that I wrote the previous paragraph with the proverbial tongue in my cheek. I recognize that prayer doesn't necessarily work in that way we most[...]
Category : home Rabbi Rabbi's Journal Shabbat Tag : abraham joshua heschel diversity fireworks rabbi rabbi's journal unity
June 23, 2016 By bethmordecai no comments.
Reflection on the Cleveland Cavaliers winning the NBA Championship and our upcoming Shabbat by the Sea experience on Caring for One Another... Dear Hevreh, I confess that I was very excited when the Cleveland Cavaliers ("Cavs") won the NBA championship on Father's Day. Why is this something I have to confess to? Because I'm not a Cavs fan, I'm a Sixers fan. More to the point, I'm a Philadelphia sports fan and it surprised me that cheering for the Cavaliers to win on Sunday night felt somewhat like cheering on one of my Philly teams win. It was odd, because a part of me thought that I should not feel that way, that no team winning a championship could (or should) feel[...]
Category : home Rabbi Rabbi's Journal Tag : Cavaliers Championship Cleveland Desert Empathy Fan Philly Promised Land rabbi rabbi's journal sports
June 17, 2016 By bethmordecai no comments.
The following is a preview of a conversation this Shabbat morning in honor of Father's Day... Dear Hevreh, I'm not sure how to celebrate Father's Day. Though this will be my third Father's Day as a "father," I don't quite know how to approach the significance of this day. It it supposed to be a "ho-hum" day with the highlight being the giving of gag gifts and the telling of dad jokes? Or is it supposed to be something more significant where the role of a father is appreciated in a way analogous to (though not the same as) the way that Mother's Day is celebrated as a High Holiday on our secular calendar? I guess this question of how[...]
Category : home Rabbi Rabbi's Journal Tag : dads egalitarianism fathers day home jobs society work
May 25, 2016 By bethmordecai no comments.
Reflection on this weekend's Scholar in Residence Weekend -- From Being Jewish to Doing Jewish: Deepening Our Jewish Identities מָֽה־אָשִׁ֥יב לַיהוָ֑ה כָּֽל־תַּגְמוּל֥וֹהִי עָלָֽי׃ How can I repay unto the LORD All His bountiful dealings toward me? (Psalm 116:12) Dear Hevreh, Smiling. It's one of the most important things we can do, but also one of the hardest. We smile when we're happy, laughing, and enjoying our experience, but too often we walk into life's moments with a skeptic's frown; we demand that others impress us before rewarding them with a smile of acceptance. As a rabbi looking out at a congregation on Shabbat morning or during the holidays, the task of turning a skeptic's frown into a believer's smile can be daunting. If[...]
Category : home Rabbi Rabbi's Journal Scholar in Residence Weekend Tag : gratitude hakarat hatov mitzvah rabbi Rabbi Jonathan Porath rabbi's journal scholar in residence weekend הכרת הטוב
By bethmordecai no comments.
RABBI'S PUBLIC JOURNAL -- Follow Rabbi Saks' rabbinic journey as he leads Beth Mordecai to become an active and passionate Jewish home for the soul... Read his public journal HERE!
Category : Rabbi Rabbi's Journal Videos
May 18, 2016 By bethmordecai no comments.
The following is the first of three journals previewing this weekend's Scholar in Residence Weekend -- From Being Jewish to Doing Jewish: Deepening Our Jewish Identities. Today's installment focuses on the Friday night program around "being Jewish." Dear Hevreh, Chances are that if you're reading this message, there's been at least one seminal moment in your life when you either felt a connection to being Jewish, or (if you don't identify as Jewish) you developed an appreciation for what Judaism has to offer. In other words, regardless of our particular experiences, we share a universal feeling of the importance of whatever-it-is-that-we-call-"Jewish." Our weekend's scholar Rabbi Porath will spend some time on Friday night helping us articulate and appreciate these seminal experiences of being/feeling[...]
Category : home Rabbi Rabbi's Journal Scholar in Residence Weekend Tag : Cantor Bronwen Mullin connection inner yid Jewish rabbi Rabbi Jonathan Porath rabbi's journal scholar in residence weekend soul spark
May 13, 2016 By bethmordecai no comments.
*Note: this message is a little longer than usual Dear Hevreh, At the onset of the this week's triennial Torah reading of Parashat K'doshim (Leviticus 19:23-24), we read... כג וְכִי-תָבֹאוּ אֶל-הָאָרֶץ, וּנְטַעְתֶּם כָּל-עֵץ מַאֲכָל--וַעֲרַלְתֶּם עָרְלָתוֹ, אֶת-פִּרְיוֹ; שָׁלֹשׁ שָׁנִים, יִהְיֶה לָכֶם עֲרֵלִים--לֹא יֵאָכֵל. 23 And when ye shall come into the land, and shall have planted all manner of trees for food, then ye shall count the fruit thereof as forbidden; three years shall it be as forbidden unto you; it shall not be eaten. כד וּבַשָּׁנָה, הָרְבִיעִת, יִהְיֶה, כָּל-פִּרְיוֹ--קֹדֶשׁ הִלּוּלִים, לַיהוָה. 24 And in the fourth year all the fruit thereof shall be holy, for giving praise unto the LORD. It seem a little odd that the Israelites would not be able to eat food they just planted in the[...]
Category : home Rabbi Rabbi's Journal Scholar in Residence Weekend Torah Teachings Tag : Doing Jewish k'li yakar k'li yaqar keli yakar keli yaqar mitzvah planted planting possibilities rabbi rabbi's journal Shlomo Ephraim Luntschitz Skills torah teachings


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MND home cooked food on a budget
What is this post about?
– Eating the MND way on a budget
– Cooking 'real food' when away from home with restricted resources
– Managing with only the most basic cooking facilities
– Travelling and still eating healthily – and affordably
– Eating to fuel lots of exercise
MND on holiday!!
'Team MND' recently took a holiday – a week hiking in the French Alps. We rented a small and very basic apartment and went hiking every day, which was great fun. I've not got time to write an extensive trip review, and I don't suppose you want to read it anyway! So I'll stick to the relevant and interesting stuff.
We hiked for 5 days, covering between 11 and 17 miles per day, and climbing an average of 4500 to 7000 feet per day. On average, we spent about 10 hours out on the hills each day, and our average daily mileage was 14 miles, and 6000 feet of ascent, 6000 feet of descent. Read more


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Hands raised if you stop, stared and drooled over the cover because I know I sure did. However, that is not the reason why I wanted to read Back Piece. Author L.A. Witt has become somewhat of a 1-click addiction for me. While I am not a huge fan of… Read more »
Genre: Military Romance
Review: Aces Wild (Elite Ops #1) by Emmy Curtis
This is my first book by Emmy Curtis and I liked the fantastic ride Aces Wild takes us on! This story is very fast-paced and stayed ramped up for most of the book! Major Eleanor Daniels has worked hard for her position in Red Flag and is not going to let any… Read more »
Review: Dress Blues: A Second Chance Military Romance (Recalled to Love Book 1) by Lisa Carlisle
Wow! Dress Blues is a fun second chance romance that just makes you smile! It's a story that grabs you by the heart and gives it a little tug. Vivi and Jack met at a rock climbing gym and immediately hit it off! Sparks flew and things were going along famously… Read more »
Review – Rude (King's Harlots #3) by J.M. Walker
Ask me how long it's been since a book has made me cry. Not, eyes getting glossy. Streams of water falling from my eyes, kind of crying. Actually. Scratch that. Don't bother asking because I honestly can't remember the last time. Until this book… DISCLAIMER – 1) THIS IS NOT… Read more »
Review: At Attention (Out of Uniform #2) by Annabeth Albert
Apollo is a widower whose husband passed two years ago. He's left raising their twin daughters by himself. Grief stricken, he hasn't been able to move on with his life. He's merely existing day to day. When Apollo's mom is leaving for a trip of a lifetime, Apollo knows he's… Read more »
Review – Saved By The SEAL (Battle Scars #2) by Diana Gardin
Diana Gardin writes military well. She creates believable alpha warriors including Grisham Abbott. Grisham is complex. He's at a crossroads he's unprepared for. By the opening of this story, he's adept with his prosthesis and has dealt with most of the recovery process. Gardin treats Grisham's disability as just another… Read more »
Review: Sunrise Canyon (The New American Series) by Janet Dailey
A veteran that has lost his way and a therapist who specializes in children and horses need to work together to help each other heal. In order to do that they must let go of their pride and begin to trust someone else. They have many trials that lay ahead… Read more »
Review – Hard Play (Delta Force Brotherhood) by Sheryl Nantus
A complete and total lover of Maya Banks' KGI series, I immediately wanted this book. I mean, if you're going to compare it in a blurb, I'll give it a shot. I'm happy I took the leap. I think that this is a pretty good start to a series (even… Read more »
Review – In a Ranger's Arms (The Men of At Ease Ranch #1) by Donna Michaels
With one of the funniest opening scenes I've ever read, Donna Michaels' had my attention immediately and In A Ranger's Arms continued to be a great read. The book is a mix of funny, serious, sensuous and sweet. Jovy and Stone are immensely likeable and their chemistry is tantalizing but… Read more »
Review – Lit Fuse (Nashville's Finest 0.5) by Caisey Quinn
Holy Mother of WHAT???!!!!! Wow, just wow. I'm still trying to pick my mouth off the floor, so please excuse me if I start rambling. WOOOOOOOW!!!! Ok, Ok. I'll at least try to write a review for this one.. What a way to start a series. I mean, usually in… Read more »
Review – Reckless Hearts (Reckless Hearts #1) by Heather Van Fleet
Heather Van Fleet's debut novel is well written. The characters are complex and the story has interesting variations on the nanny theme. The tension between Collin and Addison is intense and spontaneous but never easy going. The sexual tension is mutual and strong. The emotional tension is too but in… Read more »
Review – Seconds to Sunrise (Black Ops: Automatik #3) by Nico Rosso
Have I mentioned how much I really like the concept of Automatik and the different members of the team? Well, I do. So much so that I don't even read the blurb anymore. I just know that I want to read it. And it's a good thing I picked this… Read more »
Review: Off Base (Out of Uniform #1) by Annabeth Albert
Off Base has a new adult feel to it that I wasn't exactly expecting. I'm still not sure how I felt about that unexpected aspect. I knew going in to the book that one of the characters was a virgin. That should have been a warning to the new adult… Read more »
Review – On Broken Wings (Wild Aces #3) by Chanel Cleeton
The book opens with the most gut-wrenching scene a young wife can go through. Dani's lost everything and must find a way to go on. She does so as well as can be expected with the support of her wonderful friends. Easy has been there for her every time she's… Read more »
Review – The Protector (Sons of Texas #2) by Donna Grant
The Protector is a well written, interesting story with engaging characters. There's plenty of nail-biting suspense as Cullen and Mia go up against the worst group of bad guys ever. The two are well trained and highly effective at what they do. I loved that Cullen found Mia' strength so… Read more »
Review – Enticement (Master Class #2) by Sierra Cartwright
In to BDSM? Curious about it? This is probably one of the safest BDSM experience reads I've read in a very long time. But if you're looking for a deep, getting to know the characters and dive in to a story that will go on and on and on and…..yeah,… Read more »
Review – Grim (King's Harlots, #2.5) by J.M. Walker
Batta Bing, Batta Bang…short and to the point with just the right amount of information and sex to get you through…until we start obsessing over the next one, that is. THIS IS NOT A STANDALONE! Remember in Stain (KH #2) when we notice major tension between Jay and Angel while… Read more »
Review: Taming the Vampire: A Taming the Alpha Big Box Set
Taming the Vampire is 1500 pages of amazing stories by a who slew of amazing authors. My initial intent was to write a review for each book. Yes a review for each of the 28 stories and I had them all done. BUT, and there is always a but, re-reading… Read more »


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Another cooling tip - try to be aware of the direction of the ventilation where you are - and if it is, say, for example cool outside, but still warm inside, direct the cool air in (and the warm air out) rather than just moving around the warm air inside!
Sounds obvious, but a couple of times I have re-arranged the standing fans at church to really cool us off by bringing in fresh outside air!
I also have an updraft in the hall of my apartment building, so I keep my door open, with screening in front of it, to make use of that source of ventilation.
By pamphyila from Los Angeles
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We live with no AC in a pretty warm stretch of Northern CA and our bedrooms are all upstairs. Last year I read to place the fan blowing OUTSIDE when it was hotter inside than out to get the warm air out, then flip it around. I was AMAZED at the change in how cool our room was, sleepable!!!! My husband swore it wouldn't work, but I went out and bought a new fan this year (last years was old and clanky) and it's been great. He still likes to keep the screen door closed at night for some reason (we comprimise and it leave it open a foot or so {more if I can open it when he is asleep!}) and the fan on, but now the fan isn't just moving hot air around, it's cool!
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AP physics
posted by RNH .
A 2.10x10^3 kg car starts from rest at the top of a 5.8 m long driveway that is sloped at 25° with the horizontal. If an average friction force of 4.0X10^3 N impedes the motion, find the speed of the car at the bottom of the driveway.
im using the equation -(frictional force)=PE(gravitional initial)+KE(final) im getting the answer wrong and am wondering if i need to take 5.8sin25 for y in the PE part.
i just Really Need Help


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TANCET Answer Key 2017 MCA MBA ME M.Tech 25 & 26 March Paper Solutions @ www.annauniv.edu
TANCET Answer Key 2017 Anna University, Chennai has successfully conducted the Tamil Nadu Common Entrance Test on 25th & 26th March 2017 at different examination centers across the state. Lots of applicants have applied & appeared in the exam at their respective exam centers. As the examination had been over now the candidates are searching… Read More »