text:
Chi-Town Vs. Mr Flames World Tourney round 1
Posted in the Hip-Hop Forum
"Horrocore-Tourna ment 2012CHAMP"
Since: May 11
Calgary, Canada
#1 Jan 26, 2013
alright boys. first round, first pair. lets get it cracking.
chi-towns country: bulgaria
Mr Flames country; denmark
8 bars is the set bar count. im gunna be VERY strict on this for this tourney. MUST be 8 bars. 1 more bar and u get DQ'd same with 1 bar less. this site needs some stricter guidelines. ima enforce it. so make sure ur drop is 8 bars. have fun. lol.
ALSO: you MUST drop in 3 days, otherwise u get DQ'd. IF, for some reason, there is no way on earth u can drop in the alloted time i WILL give 2 day extension. if u dont drop by 5 days, ur dq'd as well.
Since: Jan 13
Location hidden
#2 Jan 26, 2013
Okay I'll get right on it
Since: Jan 13
Location hidden
#3 Jan 27, 2013
ill post it tommorow at 2(ur time)
#4 Jan 27, 2013
Take my sword and put it in your esophagus
Your first mistake was going up against a gladiator like spartucus
You'll get smoked like a rasta
Leave your head laying in a plate of pasta
Bulgarias army never lost a flag
Do you really think I'll loose in a battle to this Denmark fag?
Little stupid adolescent
Go take an antidepressant
Cancer capital of the world
Bunch of drunkards that drink to hurel
Meanwhile we invented the digital computer
While your country became the worlds fourth most polluter
[email protected] this prozak nation
With there high taxation drink for relaxation cause they have no expectations
"There's something rotten in Denmark" must be Ms. Flamer
Ripped em to shreds so me winning is a no brainer
Spartucus--from Thrace now bulgeria
Pasta--denmarks favorite everyday dish
Bulgerias army---has never lost a flag despite being in recent wars
Antidepressant---one of the worlds leaders in taking antidepressant even given to kids
Cancer capital of the world--- award given to Denmark after studies showed such high rate and largely increasing
Denmark=drunk. People are known to be drunkards
Balgarian invented the first digital CPU
Denmark is the worlds fourth biggest polluter
High taxation in Denmark at 57%
"There's something rotten in Denmark" Shakespeare quote from Hamlet
Flamer--- word we use in Chicago for fags and gays
Since: Jan 13
Location hidden
#5 Jan 28, 2013
Bulgaria ur a shame only got 2 medals
We got nine in the games hard as metal
U guys have foreign lands and douche bags
We got 433 islands and green lands
We so good first country to legalize pornograpghy
Bulgaria boarded 5 country's but that's geography
We the best ask Sweden they tried us
When we finished they cried and went home in there minibus
U see our Vikings went pass Vinland
And took parts of England
Remember Tour de France 1996 yea we won that
U guys felt kinda sick
See we work with NATO
and Bulgaria just playing ghetto
we got cool fountains and big buildings
U guys have mule mountains and pig kings
fravel har en nice dag Denmark nummer et (not apart of the rap)
Th last sentence means : goodbye have a nice day but Denmark still number 1
NATO- a organization between USA
Yea u understand the rest
"Read it backwards"
Since: Jan 13
Saint Albans, NY
#6 Jan 28, 2013
You've earned my respect. you should write more like this than you usually do.
Since: Jan 13
Location hidden
#7 Jan 28, 2013
Thanks that means alot
#8 Jan 28, 2013
Good Mr. Flames good luck
Since: Jan 13
Location hidden
#9 Jan 28, 2013
U to I'm kinda nervous this is my first time doing something like this
"Horrocore-Tourna ment 2012CHAMP"
Since: May 11
Calgary, Canada
#10 Jan 28, 2013
flow: chi town i found to flow better.
country reppin: chi town. hit denmark hard. on point all way thru. sorry flames.
Multies: chi town. his high taxation/relaxation/expectatio n line
nameplay: didnt see any so nill.
OVERALL consistency of the drop: chi town. definitly. some of mr flames bars just didnt really stand out to me. but that'll come with time/experience. chi town is a force to be reckoned with.
mvgt: chi town. flames, a decent first tourney drop, but definitly gunna need some amperage in the work. did ur homework tho and pulled out some interesting stuff to talk about, thats good. overall good job u two!
#11 Jan 28, 2013
That's what's up good battle Mr. Flames
Durham, UK
#12 Jan 29, 2013
That's dope Mr. Flames. Good work!
Durham, UK
#13 Jan 29, 2013
Nice work dawg! Two new real talents on show here!
"Horrocore-Tourna ment 2012CHAMP"
Since: May 11
Calgary, Canada
#14 Feb 1, 2013
we need more votes here!
"Read it backwards"
Since: Jan 13
Saint Albans, NY
#15 Feb 1, 2013
Flow: both
Knowledge of country: Mr.Flames
[his was more straight forward]
Multies: Chi-town
[mr.flames came weaker on this]
nameplay: nobody used any
My vote goes to chi-town, and only because he had more structered elements in his bars. But both drops were nice, so props for both of you.
#16 Feb 1, 2013
Flow: Chi town
Punches: Chi-town (though both had at least 1 throwaway bar)
Country: Flames
Multis: Chi-town
Nameplay: None
Concept: Flames
This was a good matchup. Both drops were nice. I will say Flames had the nicest punch of the battle with
We so good first country to legalize pornograpghy
Bulgaria boarded 5 country's but that's geography
Flames needs to choose better words and make nothing is being forced. I felt he had at least two bars that felt forced.
I also think it should be in 3rd person, but since they both dropped in 1st person I gave them a pass, but I would have probably edged it out to the 3rd person drop since it is a country and not a person being discussed (unless they perhaps reffered to themselves as "we" and their opponent as "they."
Chi town could of also have merged the bar with the antidepressents with another bar.
Little stupid adolescent
Go take an antidepressant
and this one
[email protected] this prozak nation
With there high taxation drink for relaxation cause they have no expectations
could have been edited and merged together. Chi-town's presentation was a little more cleaner and consistent so:
MVGT Chi-town
Since: Jan 13
Location hidden
#17 Feb 1, 2013
This was my first time doing something like this it doesn't seem to be going good for me at the moment but I can learn from this and make a better one next tourney
"Horrocore-Tourna ment 2012CHAMP"
Since: May 11
Calgary, Canada
#18 Feb 2, 2013
so far chi towns leading, i pree sure he'll take this lol. but lets get 1 or 2 more votes from ppl on this, just so its fair. the rrc/phaze battle got a ton of votes, which is what i wanted to see, lets get a few more here to end this final
Since: Aug 12
Location hidden
#19 Feb 2, 2013
Okay ..wow I stand corrected.
Im highly impressed with Mr Flames mainly cause I didnt even expect this level of wit from him..
FLOW++ Both.. pretty even on this one
COUNTRY++ Flames.. he did real great in this area,Chi did real good to but flame edged him out.
MULTI++ CHI flames had a few singles
NAMEPLAY++ None
OVERALL++ Chitown I enjoyed both reads but CHI had a lil more brutalness, and still repped his country enough to keep more relevant lines..
I agree with Shini on Mr Flames line being kinda hot!
We so good first country to legalize pornograpghy
Bulgaria boarded 5 country's but that's geography
I liked this line from CHI too:
Bulgarias army never lost a flag
Do you really think I'll loose in a battle to this Denmark fag?
coo battle guys... but
Since: Jan 13
Location hidden
#20 Feb 2, 2013
Okay yea the rap is not good enough to win at the moment but I told u I could make a decent rap If i sat down and thinked and thank you for the encouragement
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NBC News, December 14, 2015. This is a very unbalanced article. No notion that gun control may make it more likely that people will be victims of violent crime.
John Lott, a longtime gun researcher and president of the Crime Prevention Research Center, said that the trend of states making it easier for permit holders to carry concealed weapons has continued since Sandy Hook.
The New York Times continues its reliance on the Violence Policy Center's discussion about concealed handgun permit holders.
since 2007, at least 763 people have been killed in 579 shootings that did not involve self-defense.
The Times didn't take our letter to the editor, but this is what we sent in:
…Dear Letters Editor:The Times erroneously asserts that over 8.5 years there were 763 non-self-defense gun deaths nationwide by concealed handgun permit holders ("The Concealed-Carry Fantasy," October 26).
Letters that we submitted, media bias on guns, Violence Policy Center
John Lott has a new op-ed at the Daily Caller:
Last week, a New York Times editorial shockingly claimed that American concealed handgun permit holders have been responsible for 763 non-self-defense deaths since 2007. The Times editorial cites these numbers as proof of the "myth of the vigilant citizen" and "foolhardy notion of quick-draw resistance."
But the numbers they rely on from the Violence Policy Center are fatally flawed, quadruple counting legitimate self-defense cases as criminal murders and blaming suicides on permits when the suicides don't even involve guns.
How law-abiding are concealed handgun permit holders, media bias on guns, op-ed, Violence Policy Center
The Washington Post's Christopher Ingraham has another new post on gun control (earlier ones here), where he is claiming that most people are wrong to believe that permitted concealed handguns make them safer. In this case, Ingraham is responding to a new Gallup poll that finds that by a 56-to-41 percent margin Americans believe that more people legally carrying permitted concealed handguns would make them safer.…
John Lott talked to Jeff Glor on CBS's Evening News about guns (Thursday, August 27th, 2015, 6:45 to 6:47 PM).
. . . John Lott, the president of the Crime Prevention Research Center and author of the book, "More Guns, Less Crime," says he does not buy the idea that gun violence should be treated as a public health issue.
Click on screen shots to enlarge.
Christopher Ingraham at the Washington Post has another article on guns. Unfortunately, Ingraham explicitly ignores the FBI's definition on mass shootings. The cases he ends up with involve very few murders and are heavily biased to include gang and other criminal activity. Curbing gang violence is important, and it could be done pretty simply: stop enforcing the laws or legalize drugs. …
John Lott's latest piece at the Pittsburgh Tribune-Review starts this way:
False claims about police brutality are poisoning race relations.
This feeling of "unfairness," as President Obama noted in his weekly address on May 16, is "fuel(ing) the kind of unrest that we've seen in places like Baltimore, Ferguson and New York."
The riots it incites threaten people's lives and destroy businesses.
The New York Times recently had this editorial:
Seventy-thousand people are expected to attend the National Rifle Association's convention opening on Friday in Tennessee, but they won't be allowed to carry firearms in one of the main convention venues. This may run counter to the N.R.A.'s ideas about carrying guns everywhere, from elementary schools to workplaces.
Perry Chiaramonte's news article has this discussion of the CPRC and our survey that Gary Mauser oversaw of economists and their views on gun control:
Critics who think the media has an anti-firearm agenda won't like the lineup behind a high-powered, upcoming seminar aimed at training reporters to cover the issue of gun violence.
John Lott talked to Jim Bohannon on his show America in the Morning for a discussion of concealed handgun laws. This first clip is just 6 minutes long. Friday, February 20th, 2015 during the 5 AM hour.
John Lott talked to Jim Bohannon on his widely listened to show "Late Night with Jim Bohannon" about the problems with the New York Times claims about concealed carry permit holders and the state of gun control in America.…


text:
Ford Mustang LX Questions
Get answers to questions about your Ford Mustang LX at RepairPal. Find solutions, diagnose problems and get back on the road.Refine by vehicle
Wen put in gear it jerks and shutdown
It might crank and runs good you might go out their and it turn over and hit but won't crank
already replaced the switch.. Same problem
Overheating occurs quickly when driving short distance,loud rattling noise begins when pushing accelerator only as temp climbs then when gauge reaches highest level it shuts off . Has water and oil,but oil was really low.Has smell and A little smoke when raised hood.Already has a rack and pinion leak and bad ignition computer,but don't know if that is relevant or related.told could be related to the head or engine going bad.know zero about cars and no money for professional diagnoses but ANY opinion would be greatly appreciated to know at least a starting point
Began to light up and off check engine light car is like new only has 56000 miles
bought this car used. we suspected it had a little damage to the axle because there was uneven wear on the rear brake drums. replaced rear brakes. squeaking stopped, now started again less than 6 mos. later. Now I went to drive yesterday and i heard a crunching squeal noise ! sounds like a soda can being crushed by steel cog-wheels. i read a q&a talking about worn outer tie rods, is this the problem or something else?
92 mustang lx 2.3l,
Tryed starting the car but it would crank over everything else work( lights, gauges, fuel pump,etc) but would not crank. After a few tries of trying to start the car everything quit working. No light gauges fuel pump etc. but after a while the car would get the electronics back but once again after a few tries the electronics quit working and still no crank or fire
my blinkers, head lights, and brake lights are not working.
the blinkers will work with the emergency light switch but not the signal switch.
I just bought the car. I see there is a newer stereo and looks like there is wiring for sub/amp
was wondering where I should start.
fuses were good.
Idles rough and dies in park and neutral only. Does fine while in gear. Would the neutral safety switch cause this?
I have already replaced plugs, wires, EGR, throttle position sensor, and cleaned the IAC the best I could. What else could it be
Every time the transmissi is put into a new gear it shifts hard and makes the car move. When driving the transmissi does not shift hard only when going from park, reverse and drive.
On my 1993 mustang I change the rack and pinion boots because they were leaking so I changed them now I'm still loosing power steering fluid but not much and I see no leaks. Is it Because the boots are still filling and just taking some out of the power steering pump or what?
had some interior work done on car. doors needed to be left open and the ignition was on, but not started, now engine will not crank. any ideas?
it blew a head gasket so we replaced that and it starts, runs for about 30 secs or so and just shuts down like you turned it off, it starts right up again and does it again
It has 93,000 miles on it. i just bought it a thousand miles ago. wondering what the best route to go with that would be.
Both handles were plastic and they eventually fell off completely. I have two handles already, that I bought a while back
I could use some quick helpful info on a average or good price for the replacement of the steering coupler on this vehicle. I was told by the mechanic that the part was almost obsolete and may have to be modified from an aftermarket one if they can't find one. However I was quoted a price of$282.00 for parts & labor. Is that a good deal in SF bay area? Thanks for quick respose
I have an '87 Mustang LX 2.3 4cyl and need an estimate for timing belt replacement. Your list stops at 1990. I would also like a separate estimate for steering coupler repair or replacement for the same vehicle if possible. Thanks
I think I put the battery in backwards, do the posts belong facing towards the engine or the fender? I took the old battery out several months ago and I just don't remember.
I installed two new fuel pumps into a 1993 Mustang 5.0 lx. Replaced the new one because I thought it was bad. The car runs when I install the new fuel pumps just fine on idle. Drove it around the block about a mile and it just died. Just shut down. There is now no priming sound for the fuel pump. If I were to take it out and put it back in I know it would start right back up. Replaced the Relay switch behind the the passenger strut. That was not the problem. Is a fuel pump relay and a fuel pump switch the same thing? People keep talking about a relay under the drivers seat. Don't see a kill switch in the trunk either. Not sure why it would start and run until I drive it and then stop. Thanks for any help.
Bought two fuel pumps and replaced them thinking the first new one was bad. Both ran for about ten minutes on idle. As soon as I gave it gas it died. Won't even prime. Replaced the relay switch and nothing. If I took it out again Im sure it would start after I put it back in. Why does this happen? We are at a total loss. Really ran great on idle. Now nothing at all not even the sound it makes when you previously start it. Thanks
I have had my car since new, and the alarm was factory installed. Sometimes it just goes off for no apparent reason, and now, even when it is not set, it is still going off randomly. Would this be easy to fix? Any suggestions on what I should be looking for? Or since the alarm is so old, should I just get a new alarm instead? Will a new alarm be able to be set up the same way, where the engine cannot be started without the remote being used. Thanks!
This is a 1993 LX 2.3 4 cylinder
I just did a complete tune up, new battery, new starter. All I get with the key is a click. The ignition recall was already changed by Ford dealer. The car sat all winter and I had noticed it once when I went to start it in the winter. Thought it was the starter but I guess not Could be the clutch switch I don't know.
is there a place to add oiler is it electric
U only have to move it around alittle but its aggravating . it happens all the time


text:
Our life can be challenging. Is there time for a successful career AND those we love? We are driven by our successes, but often the most important moments are those we create with each other. We all strive to 'get more' from life, but can struggle to find a positive harmonization between our career and family commitments. Business leaders and corporate performers constantly focus on achieving ambitious objectives, the next step, the next goal, and build positive lasting partnerships - but how can we bring those dynamic strengths into our private lives, far beyond the office desk into our homes? Renowned performance expert, father, and husband Dr. Christian Marcolli successfully works since decades with global business icons and Olympic gold medallists. More Life, Please! holds the essence of Dr. Marcolli's highly effective P6PROP(R) performance model, broken down for life surpassing the office. Christian takes you from adequate to astounding in easy to follow and practical steps, changing your life for the better, and helping you engage more positively with everyone you interact with. Passion, Precision, Perception, Peace, Presence and Persistence are all vital elements and essential to succeed. Supported by simple but effective tips from family and work-life integration specialist Tarina Wagschal, this is a book for those who have mastered the corporate world and are more than keen on better conquering their private and family life too! More Life, Please! is your pathway to living life to the fullest!Biografía del autor:
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The Finn failed to hold on to John Utaka's 37th-minute cross and Kanu was on hand to punish the mistake, firing in from close range to net the only goal of the game.
"It's not going to be hounding me," said Enckelman. "Conditions were wet first half, there was a bit of rain."
He added: "I am not going to make excuses but it was a new ball, I should probably have dealt with it better but on another day it might have bounced somewhere else and the defender clears it.
"But, as it was, it came straight to Kanu and he tapped it in."
Enckelman, on loan from Blackburn, is best known for his howler in a Birmingham derby when at Aston Villa.
Somehow, he allowed Olof Mellberg's throw-in to roll under his foot and into the Villa goal in a fiercely-contested clash with the Blues in September 2002.
He has since admitted to being "distraught" after that mistake, but revealed he had no such feelings this time around, adding he had "nothing to worry about".
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 Clinical and epidemiological characteristics and organization of care for patients with diabetic foot syndrome on the territory of Khanty-Mansiysk autonomous okrug – Yugra https://endojournals.ru/index.php/dia/article/view/8148
Background. Epidemiological studies in regions of Russia have revealed significant differences in the prevalence of diabetic foot syndrome (DFS).

Aims. To determine the epidemiological characteristics and associated complications of DFS in Khanty-Mansi Autonomous Okrug (KHMAO)-Yugra

Materials and methods. The epidemiological indicators and complications of diabetes were determined in diabetic patients in KHMAO-Yugra. The statistical reporting form №12 was used. Data from patients diagnosed with type 1 or type 2 diabetes and DFS were gathered from the service area of hospitals, the state registry (2007–2014) and outpatient clinics in the city of Surgut (2009–2014). A prospective observational study with active screening and characterisation of DFS was conducted.

Results. Of all patients, 43% were at high/very high risk of developing DFS. DFS was diagnosed in 4.1% of patients with diabetes and was characterised as neuropathic (57.3%), neuroischaemic (35.1%) and ischaemic (7.6%).

Conclusions. Prevention and early diagnosis of DFS is crucial in the prevention and reduction of amputations in patients with diabetes. Given that DFS can present in various forms, programmes aimed at promoting DFS awareness are required to increase the identification and treatment of this syndrome. Additionally, improvements in the statistical tests used and better organisation of the flow patients referred to general physicians, endocrinologists, podiatrists and surgeons, are also important in the prevention and early diagnosis of DFS and its associated complications.
 Yana Vladimirovna Girsh Oksana Petrovna Davidenko Copyright (c) Girsh Y.V., Davidenko O.P. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 99 107 10.14341/2072-0351-5846 Is it beneficial to the state to provide insulin-treated diabetic patients with public funds for self-monitoring blood glucose? https://endojournals.ru/index.php/dia/article/view/8305
Background. In Russia, the prevalence of diabetes continues to increase with the growing diabetes epidemic. In recent years, the paradigm of diabetes treatment has been changing, with patients increasingly becoming equal participants in the treatment process, through the introduction of self-monitoring blood glucose (SMBG). Several clinical studies have demonstrated a positive relationship between SMBG and the decline of the epidemiological and economic burden of diabetes. At present, the procurement of public funds for SMBG is below the specified level in Russia.

Aims. To investigate the potential macroeconomic benefits of public health resource allocation and the use of planned state investments to fund SMBG in insulin-treated diabetic patients.

Materials and methods. This study was conducted with data from insulin-treated diabetic patients. The epidemiological burden of this cohort was determined by the following indicators: the number of patients and the incidence of complications resulting from diabetes, disability, mortality, age and sex. The economic benefits were evaluated by the implementation of two measures: (1) procurement of public funds for the purchase of means for SMBG in patients with insulin-treated diabetes and (2) the use of highly accurate blood glucose metres. To evaluate economic burden, the epidemiological burden was translated into monetary terms using cost-of-illness. Economic benefits were defined as reductions in economic burden.

Results. The economic benefits of public-funded blood glucose test strips for insulin-treated diabetic patients exceeded the required additional investments for their purchase by 1.5 fold. A significant reduction in the inaccuracy of blood glucose metres from 20% to 10% may reduce the economic burden by 9.36 billion RUB. The combined state benefits from the implementation of both measures would significantly decrease the economic burden of diabetes to 29.2 billion RUB.

Conclusions. Increased procurement of public funds for SMBG in insulin-treated diabetic patients would bring economic benefits that far exceed the required investments.
 Larisa Dmitrievna Popovich Marina Vladimirovna Shestakova Elena Georgievna Potapchik Alexander Yur'evich Mayorov Olga Konstantinovna Vikulova Copyright (c) Popovich L.D., Shestakova M.V., Potapchik E.G., Mayorov A.Y., Vikulova O.K. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 108 118 10.14341/7077 Post-operative insulin resistance https://endojournals.ru/index.php/dia/article/view/8171
Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear. IR has been described as a pathological condition, in which organs and tissues fail to respond to the hormone insulin, resulting in acute hyperglycaemia. Post-operative IR in patients without type 2 diabetes has been identified as an independent, negative predictor of post-operative outcome. Studies have shown a direct relationship between post-operative morbidity (including complications from infection) and total mortality in patients with acute hyperglycaemia compared with diabetic patients. IR and stress-induced hyperglycaemia in the early post-operative period may be corrected by insulin infusion; however, this has often been associated with hypoglycaemia. Detection and modification of risk factors in the pre- and intra-operative periods may decrease the frequency of IR and hyperglycaemia and eliminate the use of insulin. In this literature review, the mechanisms underlying the development and prevention of post-operative IR, and its clinical value are discussed. This study demonstrates the relationship between IR and post-operative morbidity, highlighting the benefits of a complex approach to prevent the adverse events of post-operative IR and stress-induced hyperglycaemia.
 Irina Aleksandrovna Tarasova Alexey Leonidovich Shestakov Vladimir Vladimirovich Nikoda Copyright (c) Tarasova I.A., Shestakov A.L., Nikoda V.V. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 119 125 10.14341/7637 The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus https://endojournals.ru/index.php/dia/article/view/8684
The study of diabetes mellitus (DM), its complications and related pathologies has been continuously performed for many years; however, despite the substantial work and outstanding achievements in studying the mechanisms of DM development and the success of new medicinal products for controlling glycaemia, the problems associated with the late complications of DM continue to increase. The importance of glycaemic control in the early stages of DM for the development of complications is seen only after a sufficiently long period of observation. Such a delayed effect of primary good or unsatisfactory metabolic control, which shapes the patient's clinical fate to a greater extent, is termed 'metabolic memory'. The disorders developed under the influence of hyperglycaemia persist for long periods after the normalisation of carbohydrate metabolism; moreover, the effect of previous hyperglycaemia extends over the next 20 and even 30 years. Current research is focused on the possible mechanisms of metabolic memory development, including oxidative stress, advanced glycation end products and epigenetic mechanisms. This research will provide insight into potential markers for the early development and progression of vascular complications and new therapeutic possibilities for the future. However, determining the probable 'point of no return' is more important, which implies that a point exists; after this point is crossed, the progression of vascular complications associated with DM cannot be prevented or reversed. The results of numerous experimental studies demonstrate that the prerequisite components of metabolic memory can be used as potential markers of the progression of DM complications, and may be potential therapeutic targets.
 Alexander Alexandrovich Chernikov Anastasia Sergeevna Severina Minara Shamhalovna Shamhalova Marina Vladimirovna Shestakova Copyright (c) Chernikov A.A., Severina A.S., Shamhalova M.S., Shestakova M.V. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 126 134 10.14341/7674 Clinical and morphological characteristics of wound healing in diabetic foot syndrome https://endojournals.ru/index.php/dia/article/view/8190
Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn)

Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2—unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression.

Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 ± 25 vs 32 ± 21 %, р = 0.001] and fibrotic tissue [24 ± 24 vs 49 ± 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 ± 8.1 vs 1.9 ± 4.6 (%), р = 0,02] and expression of Ki-67 [15 ± 8 vs ± 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was <50%. If the percentage of granulation tissue was <50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were >7%, the probability of healing was 0.75. For Ki-67 levels ≤7%, the probability of healing was 0.17 and the probability of not healing was 0.83.

Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn.
 Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov Copyright (c) Komelyagina E.Y., Kogan E.A., Antsiferov M.B. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 135 141 10.14341/7704 Combined insulin detemir and liraglutide therapy in type 2 diabetic patients: a base for an alliance https://endojournals.ru/index.php/dia/article/view/8296
Combined glucose-lowering therapy, comprising of basal insulin with glucagon-like peptide-1 (GLP-1) analogues, has become central to the treatment of type 2 diabetes both at the start of insulin therapy, and as an alternative to basal-bolus insulin. The combination of insulin detemir (insulin analogue) with liraglutide (GLP-1 analogue) reduces fasting and postprandial glycaemia, lowers the risk of hypoglycaemia and does not have a negative impact on body weight. In this literature review, the pharmacodynamic and pharmacokinetic profiles, as well as the potential benefits of combined insulin detemir and liraglutide therapy on diabetic nephropathy and high cardiovascular disease risk were determined. Data from randomised clinical trials and the National Registry were used to assess the clinical efficacy of combined insulin detemir and liraglutide therapy. The different mechanistic actions of insulin detemir and liraglutide resulted in an additive glucose-lowering effect, which did not affect the pharmacodynamic and pharmacokinetic profiles of each therapeutic agent.
 Lyudmila Alexandrovna Ruyatkina Maxim Sorokin Copyright (c) Ruyatkina L.A., Sorokin M. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 142 150 10.14341/7875 Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus (Draft) https://endojournals.ru/index.php/dia/article/view/8728
Hypogonadism in male patients is defined as a decrease in the serum testosterone level; it is associated with specific symptoms and/or signs (see the detailed description below). It is a common complication in diabetes mellitus. The guidelines do not review all disorders leading to the development of hypogonadism but focus on options for the treatment of hypogonadism, which is generally observed in male patients with diabetes. In the literature, data on the prevalence of hypogonadism in patients with diabetes are available. In the section on diagnostics, the medical history of patients with hypogonadism and diabetes, including the necessary methods for physical and laboratory inspection. Risk factors for and the clinical consequences of hypogonadism are separately considered. In the section on treatment options, variations in treatment using various androgenic therapeutic agents based on patients' requirements, conservation of their reproductive function, and their risk factors are provided. Special attention is given to indications of, contraindications of and risk factors for androgenic therapy in male patients with diabetes, particularly those in their advanced age. The principles of the clinical monitoring are developed. The favourable effects of androgenic therapy for hypogonadism in male patients with diabetes are shown.
 Galina Afanas'evna Melnichenko Marina Vladimirovna Shestakova Roman Viktorovich Rozhivanov Anna Leont'evna Terehova Alexey Vadimovich Zilov Daria Olegovna Ladygina Dmitriy Gennad'evich Kurbatov Copyright (c) Melnichenko G.A., Shestakova M.V., Rozhivanov R.V., Terehova A.L., Zilov A.V., Ladygina D.O., Kurbatov D.G. http://creativecommons.org/licenses/by-nc-sa/4.0 2017-06-20 2017-06-20 20 2 151 160 10.14341/7884


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Hanger is a narrower, hybrid, single track flow trail features steeper, banked turns and is a fun alternative to middle Lava Flow.
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