text:
The incidence of type 1 diabetes has, progressively, increased worldwide over the last decades and also in Continental Italian population. Previous studies performed in northern European countries, showed, alongside a general increase in the disease incidence, a decreasing frequency of the highest risk HLA genotype in type 1 diabetes populations, thus emphasizing the role of environmental factors. The aim of the study was to evaluate whether a decreasing trend of high risk HLA, CTLA-4 and PTPN22 genotypes would be present in type 1 diabetes subjects of Continental Italy, a country considered at low incidence of the disease compared to northern European populations. N = 765 type 1 diabetes patients diagnosed from 1980 to 2012 in Lazio region were included. For HLA, CTLA4 and PTPN22 temporal trend evaluation, subjects were subdivided into groups of years according to age at diagnosis. All subjects were typed for HLA-DRB1 and DQB1 by a reverse line blot. The CT60 polymorphism of the CTLA4 and C1858T of the PTPN22 gene were genotyped using ABI PRISM 7900HT (n = 419 and n = 364 respectively). HLA genotypes were divided in high, moderate and low risk categories. The proportion of the HLA risk categories was not statistically different over the three decades in subjects with age of onset <15 years and ≥15 years. The genotype distribution of CT60 polymorphism of CTLA4 gene did not show any change in the frequencies during time. The analysis of the PTPN22 C1858T variant revealed, instead, that the frequency of CT+TT susceptibility genotypes decreased during time (23.9% vs 13.6%, p = 0.017). We can hypothesize that the pressure of the diabetogenic environment could be milder and therefore not sufficient to reduce the need of a strong genetic background (HLA) "to precipitate" diabetes; the increased pressure of the environment could have, instead, some effects on minor susceptibility genes in our population.
Citation: Spoletini M, Zampetti S, Campagna G, Marandola L, Capizzi M, Buzzetti R, et al. (2013) Temporal Trends of HLA, CTLA-4 and PTPN22 Genotype Frequencies among Type 1 Diabetes in Continental Italy. PLoS ONE 8(4): e61331. https://doi.org/10.1371/journal.pone.0061331
Editor: Massimo Pietropaolo, University of Michigan Medical School, United States of America
Received: January 24, 2013; Accepted: March 8, 2013; Published: April 17, 2013
Copyright: © 2013 Spoletini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by Diabetes, Endocrinology and Metabolism (DEM) Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: Raffaella Buzzetti is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
The incidence of type 1 diabetes has increased progressively over the last half century [1] especially in young children. In Continental Italian population (Lazio region), characterized by a low incidence of the disease, we observed that the type 1 diabetes incidence has doubled in the 2004–2009 period compared to the 1989–1993 period, considering the 0–14 year age group [2]. The disease is a complex disorder caused by multiple genes, which interact with environmental factors. The genetic susceptibility will determine the probability of an unwanted outcome to the initial exposure but some environmental factors may influence the rate of progression [1]. The major genes responsible for at least 50% of the type 1 diabetes genetic component are human leukocyte antigen (HLA) linked [3]. As in the other Caucasian populations, the DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 genotype confers the highest risk also in Italy where, however, only 1% of the general population carries this genotype compared to 2.5% of the general population of northern European countries [4]. Other polymorphisms have been reported to be associated with type 1 diabetes, among those the Cytotoxic T Lymphocyte–Associated Antigen-4 (CTLA-4) and in the Protein Tyrosine Phosphatase Non-receptor type 2 (PTPN22) genes, [5]–[7]. Some studies, performed in northern European countries or in patients of Anglo-Saxon origin characterized by a high incidence of the disease [8] showed a decreasing frequency of the high risk HLA genotype in type 1 diabetes patients over the last decades [9]–[12], thus emphasizing the role of environmental factors. The aim of the present study was to evaluate whether a decreasing trend of high risk HLA, CTLA-4 and PTPN22 genotype distributions would be present in Continental Italian population.
Subjects for this study include n = 765 type 1 diabetes patients diagnosed from 1980 to 2012 recruited by participating centers of the IMDIAB group in Continental Italy (Lazio region). The diagnosis of type 1 diabetes was based on the American Diabetes Association (ADA) classification criteria [13].
Our research involved human participants and has been approved by the "Sapienza" University ethical committee and a written informed consent was obtained from all participating subjects. Written inform consent has been obtained from parents or legal guardian for all the children participating to the study. All clinical investigation have been conducted according to the principles expressed in the Declaration of Helsinki.
All subjects were Caucasians with parents of Italian origin. The age at diagnosis ranged from 1 to 49 years (12.7±8.9). Subjects were sub-divided into two categories: <15 years of age at diagnosis and ≥15 of age at diagnosis. For HLA temporal trend evaluation, all subjects were grouped by three decades of diagnosis: 1980–1989, 1990–1999, 2000–2012; for PTPN22 and CTLA4 they were divided into two groups of years of diagnosis: 1980–1995, 1996–2012 due to the smaller number of subjects evaluated, n = 419 and n = 364 respectively.
The HLA genotypes were classified in three risk categories based on the absolute risk values (AR) previously estimated in Continental Italian population (Lazio region) [14]: (1) High risk (AR = 1∶23) for DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 genotype (DRB1*04 different from 0403, 06, 11); (2) Moderate risk (AR = 1∶150) for DRB1*04-DQB1*0302/DRB1*04-DQB1*0302, DRB1*03-DQB1*0201/DRB1*03-DQB1*0201, DRB1*04-DQB1*0302/X (X different from DRB1*02, 03, DRB1*04-DQB1*0302 (DRB1*04 not 0403, 06, 11) or DQB1*0602) and DRB1*03/X (X different from DRB1*02, 03, DRB1*04-DQB1*0302 (DRB1*04 not 0403, 06, 11) or DQB1*0602 genotypes; (3) Low risk (AR = 1∶1100) for the remaining genotypes.
Blood samples were collected and were stored at −20°C until used for genomic extraction of DNA. Genomic DNA was extracted using QIAamp DNA Blood Kit (QIAGEN Genomics Inc., Bothell, WA). All subjects were typed for HLA-DRB1 and DQB1 loci by polymerase chain reaction (PCR) followed by a reverse line blot assay using an array of immobilized sequence–specific oligonucleotide probes, as previously described [14]. Probes were kindly provided by Dr H. A. Erlich and T. Bugawan (not commercial kit; Roche Molecular System, Alameda USA). The CT60 polymorphism of the CTLA4 gene and the missense SNP C1858T of the PTPN22 gene were genotyped using the fluorogenic 5′ nuclease assay application of the ABI PRISM 7900HT Sequence Detection System (ABI, Foster City, CA) in [15], [16].
Comparisons of HLA, PTPN22 and CTLA-4 genotype frequencies between the cohorts over time were assessed by the Chi square or by Fischer test. A probability value of 0.05 or less was considered to be statistically significant. Based on the genotype frequencies of HLA (DRB1 and DQB1), CTLA4 and PTPN22 in Italian type 1 diabetes population, we should be able to identify statistical differences between the groups analysed with a power of 96%, 93% and 90% respectively and a p value <0.05.
The mean age at diagnosis of type 1 diabetes was 12.7±8.9 years (mean ± SD), and did not differ across decades of diagnosis. The distribution of HLA genotype categories in subjects with age of onset <15 and ≥15 years, according to the three groups of decades is shown in Table 1. We observed that the proportion of the three HLA risk genotype categories, was not statistically different between the three cohorts in subjects with age of onset <15 years and in subjects with age of onset ≥15 years. Table 2 shows the genotype frequencies of the CT60 polymorphism of CTLA-4 and PTPN22 C1858T variant in type 1 diabetes subjects sub-divided according to the year of diagnosis. The genotype distribution of CT60 polymorphism of CTLA4 gene did not show any change in the frequencies during time. Instead, the analysis of the PTPN22 C1858T variant revealed that the frequency of CT+TT susceptibility genotypes significantly decreased during time (23.9% vs 13.6%, p = 0.017).
In the present study we did not observe any significant temporal change in HLA class II genotype distributions, including the highest risk DRB1*03-DQB1*0201/DRB1*04-DQB1*0302, over the last decades, both in type 1 diabetes children <15 years and in adult subjects, alongside a general increase in the disease incidence. In Continental Italy (Lazio region) type 1 diabetes incidence doubled in the years 2004–2009 (15.68 new cases per 100,000 per year <15 years of age with a peak in 2004∶17.3 for 100,000) compared to 1989–1993 and to 1990–1999 periods of time (7.9 and 8.8 new cases per 100,000 per year <15 years of age respectively) [2].
According to our results, a recent study showed no changes in HLA genotype frequencies in a large sample of type 1 diabetes subjects with age at onset ≤20 from Germany and Austria [17]. They observed that the highest risk HLA genotype was associated with a lower age at onset, as previously described in our population [18].
This finding is, apparently, in contrast with a decreasing trend of the highest risk HLA genotype observed, over the last decades, in northern European countries [9], [10], [11], [12], [19], [20] as well as in Australia, where a "predominantly Anglo-Celtic European population" was evaluated, and in United States [12] (Table 3).
Studies performed in northern European populations demonstrated the same decreasing trend of the highest HLA susceptible genotype in children <18 years, although this frequency decreased from 35.6% in the decade 1980–1989 to 19.1% in 2000- in Swedish population [20], while decreased from 25.3% to 18.2%, in the same period of time, in the Finnish population [10]. Gillespie et al. [9] observed a significant decreasing frequency of the highest risk HLA genotype DR3-DQ2/DR4-DQ8 over decades in children ≤15 years of age, stressing the concept that a major environmental effect could have been accelerated the type 1 diabetes onset, thus diluting the concentration of high risk HLA susceptible genotypes in type 1 diabetes population. Fourlanos et al. showing a significant decreasing trend of the highest risk HLA genotype from 79% in 1950–1969 to 28% in 2000–2005 [12], in presence of an increase in type 1 diabetes incidence, concluded that changing environmental conditions have increased the chance to get the disease.
Vehik K et al [11], showed that the frequency of the DRB1*03-DQB1*02/DRB1*04-DQB1*03 was higher (39%) in type 1 diabetes children both from Hispanic and non Hispanic origin diagnosed during the 1978–1988 period than in those diagnosed during 2002–2004 (28%). The Authors concluded that the increasing environmental exposure is now able to trigger type 1 diabetes in subjects who are less genetically susceptible. This result was confirmed by two larger data sets of mainly Caucasian subjects (86.4%) with a minority of Hispanic and African American, still from USA, where there appeared a significant decrease of the highest risk DR3/DR4-DQB1*0302, over time, together with an increased percent of other HLA genotypes without HLA-DR3 or DR4 [19].
The reason why the highest HLA susceptible genotype tends to be constant in some populations while decreasing in others is not clear.
The two groups of populations (Italian and German vs the others) mainly differ for a) type 1 diabetes incidence, b) "ab initio" (early 80′) frequency of the HLA class II genotypes in type 1 diabetes populations, both evidences being related, at least in part.
The main difference between the two groups of populations regards the incidence of the disease, Italian [2] and German [21] populations being characterized by a moderate/low incidence (approximately 15 new cases per 100,000 per year <15 years) compared to the other countries characterized by a high incidence of the disease (new cases per 100,000 per year <15 years: Finland 64.2, Sweden 39.6, UK 26.4, USA 26.4 and Australia 23.1 [22], [23], [8], [24], [25].
Then, in Italian and German populations, the DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 frequency, in type 1 diabetes population, was around 25% in the 80′ compared to >35% of that reported in the northern European countries at that time, except Finland. This finding reflected the low frequency of DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 in the general populations of Italy and German and could be, at least in part, the reason why the incidence of the disease has been low so far in these countries, assuming that the Odds Ratio (ORs) for every specific genotype tended, at that time, to be constant in all Caucasian populations.
Over the past few decades we assisted at a decreasing frequency of the highest HLA susceptible genotype in the diabetes population of countries with a high incidence of the disease, but not in those with a low incidence. Based on these evidences we can speculate that different environmental factors in various populations could differently influence the penetrance of HLA genes. Thus, populations with a lower incidence could be at an earlier stage of the natural evolution of diabetes history; the pressure of the diabetogenic environment could be milder and still "polarized" to the highest HLA genotype, as not sufficient to reduce the need of a strong genetic background (HLA) "to precipitate" diabetes. A logical consequence is that the HLA class II genotypes ORs appear now to be different in the different populations.
Viral infections [26], physical inactivity, excess of food intake or excessive hygiene may contribute to the increase incidence of type 1 diabetes [27]. It is conceivable that a decreased microbial load in early life may have a major impact on the programming of the immune system, particularly the gut-associated lymphoid tissue [28].
Environmental factors could either modify the penetrance of susceptibility genes, or, as triggering factors, could contribute directly to the incidence. It has been hypothesized that changes in penetrance might be linked to patterns of childhood immunization, but this has yet to be confirmed [29]. Environmental exposures to dietary antigens and microbes could be implicated in the increasing incidence of type 1 diabetes. However, no single pathogenic environmental agent has been identified that explains all cases [30].
Due to the limited sample size of subjects, we sub-divided the genotype distribution of CTLA4 and PTPN22 into two groups: 1980–1995 and 1996–2012 according to the year of diagnosis of type 1 diabetes. As well as for HLA genotypes, also the distribution of CT60 polymorphism of CTLA4 gene did not show any change in the frequencies during time, as previously demonstrated [10].
Conversely, we observed that the frequency of CT+TT susceptibility genotypes of PTPN22 gene decreased during time. For our knowledge this is the first study to analyze the PTPN22 genotype frequency in type 1 diabetes during decades. The risk conferred by this genotype to the disease is quite small (OR = 2.48) [31] compared to that conferred by HLA DRB1*03-DQB1*0201/DRB1*4-DQB1*0302 in our population OR = 24.7 [14]. The increased pressure of the environment could have some effects on minor susceptibility genes and still not on the major HLA susceptibility component in our population.
Our study has some limitations, the most important one is due to the small number of subjects who took part to this study in the last decade compared to the previous ones. Nevertheless our data contribute to clarify that the increase in type 1 diabetes over the last decades might be explained by a complex interactions between genes and environmental risk factors which may differ in the different populations. The epidemiology of type 1 diabetes suggests that varying gene–environment interactions are likely triggering and/or accelerating the autoimmune destruction of β-cells leading to complete insulin deficiency [32]. When the T susceptibility allele of PTPN22 gene is not present the environmental factors could have a predominant role in the type 1 diabetes pathogenesis.
We can hypothesize that also epigenetic regulation could be one way to explain the rapid increase in incidence and could be a central mechanism by which environmental factors can influence the development of type 1 diabetes [33].
Author Contributions
Conceived and designed the experiments: RB. Performed the experiments: MS SZ. Analyzed the data: GC. Contributed reagents/materials/analysis tools: LM MC. Wrote the paper: RB MS. Recruitment of patients: IMDIAB Study Group RB.
- 1. Gale EA (2002) The rise of childhood type 1 diabetes in the 20th century. Diabetes 51: 3353–61.
- 2.
Bizzarri C, Patera IP, Arnaldi C, Petrucci S, Bitti ML, et al.. (2010) Incidence of type 1 diabetes has doubled in Rome and the Lazio Region in the 0- to 14-year age-group: a 6-year prospective study (2004–2009). Diabetes Care 33:e 140.
- 3. Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, et al. (1996) The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 59: 1134–1148.
- 4. Hermann R, Bartsocas CS, Soltész G, Vazeou A, Paschou P, et al. (2004) Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence. Diabetes Metab Res Rev 20: 322–329.
- 5. Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 5: 1075–1080.
- 6. Ueda H, Howson JM, Esposito L, Heward J, Snook H, et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506–511.
- 7. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, et al. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36: 337–338.
- 8. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, et al. (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 373: 2027–2033.
- 9. Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, et al. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 364: 1699–1700.
- 10. Hermann R, Knip M, Veijola R, Simell O, Laine AP, et al. (2003) Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes–indication of an increased environmental pressure? Diabetologia 46: 420–425.
- 11. Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, et al. (2008) Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diabetes Care 31: 1392–6.
- 12. Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, et al. (2008) The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 31: 1546–1549.
- 13. Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, et al. (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21–22 October 2001. Diabetes 53: 250–264.
- 14. Buzzetti R, Galgani A, Petrone A, Del Buono ML, Erlich HA, et al. (2004) Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABFIN study). Diabetes Metab Res Rev 20: 137–143.
- 15. Petrone A, Giorgi G, Galgani A, Alemanno I, Corsello SM, et al. (2005) CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population. Thyroid 15: 232–238.
- 16. Petrone A, Spoletini M, Zampetti S, Capizzi M, Zavarella S, et al. (2008) The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control. Diabetes Care 31: 1214–1218.
- 17. Awa WL, Boehm BO, Kapellen T, Rami B, Rupprath P, et al. (2010) HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus. Eur J Endocrinol 163: 97–104.
- 18. Petrone A, Galgani A, Spoletini M, Alemanno I, Di Cola S, et al. (2005) Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype. Diabetes Metab Res Rev 21: 271–275.
- 19. Steck AK, Armstrong TK, Babu SR, Eisenbarth GS (2011) Type 1 Diabetes Genetics Consortium. Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years. Diabetes 60: 1045–1049.
- 20. Resic-Lindehammer S, Larsson K, Ortqvist E, Carlsson A, Cederwall E, et al. (2008) Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk. Acta Diabetol 45: 231–235.
- 21. Ehehalt S, Neu A, Michaelis D, Heinke P, Willasch AM, et al. (2012) Incidence of type 1 diabetes in childhood before and after the reunification of Germany–an analysis of epidemiological data, 1960–2006. Exp Clin Endocrinol Diabetes 120: 441–444.
- 22. Harjutsalo V, Podar T, Tuomilehto J (2005) Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients. Diabetes 54: 563–569.
- 23. Dahlquist GG, Nyström L, Patterson CC (2011) Swedish Childhood Diabetes Study Group, Diabetes Incidence in Sweden Study Group (2011) Incidence of type 1 diabetes in Sweden among individuals aged 0–34 years, 1983–2007: an analysis of time trends. Diabetes Care 34: 1754–1759.
- 24.
Washington RE, Orchard TJ, Arena VC, Laporte RE, Tull ES (2012) Incidence of type 1 and type 2 diabetes in youth in the US Virgin Islands, 2001–2010. Pediatr Diabetes 2012 Aug 28.
- 25. Catanzariti L, Faulks K, Moon L, Waters AM, Flack J, et al. (2009) Australia's national trends in the incidence of Type 1 diabetes in 0–14-year-olds, 2000–2006. Diabet Med 26: 596–601.
- 26.
Ghazarian L, Diana J, Simoni Y, Beaudoin L, Lehuen A (2012) Prevention or acceleration of type 1 diabetes by viruses. Cell Mol Life Sci. Epub ahead of print.
- 27. Gale EA (2002) A missing link in the hygiene hypothesis? Diabetologia 45: 588–594.
- 28. Knip M (2011) Pathogenesis of type 1 diabetes: implications for incidence trends. Horm Res Paediatr 76 Suppl 157–64.
- 29. Pitkäniemi J, Onkamo P, Tuomilehto J, Arjas E (2004) Increasing incidence of Type 1 diabetes–role for genes? BMC Genet 5: 5.
- 30.
Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, et al.. (2005) Environmental triggers and determinants of type 1 diabetes. Diabetes (Suppl 2):S125–S136.
- 31. Petrone A, Suraci C, Capizzi M, Giaccari A, Bosi E, et al. (2008) The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3. Diabetes Care 31: 534–538.
- 32. Vehik K, Dabelea D (2011) The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev 1: 3–13.
- 33.
Dang M, Buzzetti R, Pozzilli P (2012) Epigenetics in autoimmune diseases with focus on type 1 diabetes. Diabetes Diabetes Metab Res Rev. 2012 Nov 23. .


text:
Engine/Cam Breakin
View Single Post
Glad To Be Here
Streetbeasts lawsuit donor
Last photo:
Join Date: Nov 2002
Location: Canton, North Carolina
Age: 75
Posts: 2,245
Edits: 0
Thanks: 0
Thanked 9 Times in 9 Posts
Frisco's Photo Album
Originally Posted by
The following list of do's and don't's didn't sit well with the troops when I posted it originally, but if it helps even one person to prevent mushin' a cam, it's worth it. 10. Failure to run the motor at high rpms (2500 or higher, alternating 500/1000 rpm's up and/or down to allow the crank to throw oil in different places at different revs) for the first 40-45 minutes of its life. NO IDLING. NO IDLING. NO IDLING. The motor should not be run at less than 2500 rpm's for a minimum of 40 minutes. If a problem develops, shut the motor down and fix it, then resume break-in. The main source of camshaft lubrication is oil thrown off the crankshaft at speed, drainback from the oil rings and oil vapors circulating in the crankcase. At idle, the crank isn't spinning fast enough to provide sufficient oil splash to the camshaft/lifters for proper break-in protection.
12. Failure to initially adjust the valves properly. Using the "spin the pushrod until it feels tight" method will normally result in valves too tight. Holding the rocker arm tip down against the valve stem tip with one hand, jiggle the pushrod up and down with your thumb/forefinger of your other hand until all play is removed, then turn the rocker nut 1/2 to 3/4 turn to set the preload. Builders who have done hundreds of engine builds may have the "feel" to do the "twist" method, but those fellows who are doing their first few builds lack the experience to do this and will have better results with the "jiggle" method.
14. Failure to have everything ready for the motor to fire on the first few turns. Fully charged battery, good starter, known-good carburetor with full fuel bowl, source of fuel to the carburetor to allow minimum 40 minutes of uninterrupted running. Ignition timing set. NO GRINDING ON THE STARTER. NO GRINDING ON THE STARTER. NO GRINDING ON THE STARTER.
15. Failure to prime the oiling system prior to firing the motor. Prime until you get oil out of the top of each and every pushrod. Observe the oil pressure gauge to be sure pressure is registering. Priming will aid lubing the valvetrain at initial startup. It's the last area of the motor to get lubed on dry start.
16. Failure to use new lifters on a used cam. Used lifters should only be used on the very same cam, in the very same block and in the very same positions they were removed from.
All of the suggestions are excellent except the Racer Brown comment. The above suggestions are extremely important.
View Public Profile
Find all posts by Frisco

subset: commoncrawl


text:
World War Roku 2
Single childhood can be stressful
Listen, I try my best, but as the single child of an aging Baby Boomer, it can be hard to juggle my daily responsibilities. I want to give my dad the quality time I know he needs, but sometimes I just need to plop him down on the couch and let him watch World War II documentaries on the Roku 2 for a few hours.
I know, I know. Experts say he should be outside, playing Scrabble with his peers, but life can get so hectic and I need a reprieve from taking care of him. So I find some History Channel special on the Luftwaffe or something (he'll watch the same one over and over, it doesn't matter) and take a little "me time."
It's a little weird to watch his eyes just totally glaze over as the old newsreel footage starts playing, but he seems really engaged with it. The Roku 2's remote even has a headphone jack, so he can sit quietly on the couch for a few hours while I read or exercise and it doesn't even bother me.
Of course, whenever I try to turn off his program he throws a fit, but I can usually calm him down with a few Werther's Original hard candies. I know, I know, it's not great to give him sugar at this age, but I'm trying my best, OK?


text:
U.S. Has Opportunity to Reset Its Relationship With Karzai: View
For the U.S. and its NATO allies, Afghan President Hamid Karzai has been a frustrating friend. His calling for the withdrawal of the foreign troops that are fighting to preserve his government and saying on one occasion that he might join the Taliban are indefensible.
Karzai's tendency to believe that he faces unseen enemies has probably been exacerbated by the death this week of his half-brother Ahmad Wali Karzai. Yet, with President Barack Obama committed to reducing the U.S. presence in Afghanistan, finding a way to work with Karzai is critical to preventing Afghanistan from again becoming a sanctuary for al-Qaeda and other terrorist groups. The arrival of a new American team in Kabul provides an opportunity for Obama to reset his relationship with Karzai. We encourage him to do so.
The new team is led by people with excellent reputations: Ryan Crocker, who won accolades for his work as ambassador to Iraq; Lieutenant General John Allen, who will command of NATO's military forces; and Marc Grossman, who succeeds the late Richard Holbrooke as Obama's top Washington-based diplomat on Afghanistan. They are likely to find that working with Karzai tests their interpersonal skills.
A Personal Hit
The assassination of Karzai's half-brother will probably have a profound personal effect on the Afghan president. The two men were personally close, and Hamid Karzai relied on Ahmad Wali Karzai to manage the complicated tribal politics of the volatile Kandahar region. Although members of the Taliban have claimed that one of their sleeper agents killed him, it appears more likely that a trusted associate turned against him for personal reasons. This will probably confirm Hamid Karzai's view that he is besieged by enemies on all sides and can't rely on anyone, including his American partners.
Karzai's distrust of the Obama administration is exacerbated by his conviction, right or wrong, that Obama has sought to undermine him or even remove him from office. Crocker, Allen and Grossman will have to go out of their way to reassure Karzai of U.S. support. In doing so they should emulate Zalmay Khalilizad, the former U.S. ambassador to Afghanistan, and General Stanley McChrystal, the former NATO commander there, who enjoyed excellent relationships with Karzai. Both Khalilizad and McChrystal went out of their way to publically praise him and treat him as a head of state, even while delivering tougher messages in private.
Echoes of History
Ahmad Wali Karzai's killing comes on the heels of Obama's decision to begin a substantial withdrawal of U.S. forces this year, and to remove all combat forces by the end of 2014. Hamid Karzai undoubtedly views this decision as a sign that the Americans plan to abandon Afghanistan to its fate, now that the threat from al-Qaeda seems so diminished. Like most Afghans, Karzai remembers how, after a decade of supporting the anti- Soviet insurgents in the 1980s, the Americans lost interest as soon as the Soviets withdrew, condemning Afghanistan to years of chaos and the rise of the Taliban.
The perception that Washington is about to wash its hands of Afghanistan might tempt Karzai to try to cut the best deal he can with the Taliban and Pakistan or, failing that, to turn to Iran for support. It would be disastrous if America's more than 10-year commitment to Afghanistan ends with Tehran or Islamabad as Kabul's most influential foreign partner.
To boost Karzai's confidence and strengthen his negotiating hand with the Taliban, Obama should reiterate his interest in a long-term strategic partnership with Afghanistan, including a commitment to keep trainers and other support troops there after 2014. The Americans will leave behind the largest and best trained military in Afghanistan's history, but for the foreseeable future the Afghan economy will be too weak to finance it. Obama can resolve this problem by committing the U.S. and its allies to pay for the Afghan security forces until the government is no longer threatened by extremists.
Obama should also try to develop a personal rapport with Karzai, as President George W. Bush did. If Obama wants to salvage success from his Afghan policy he will have to work the Karzai account hard, and should initiate a regular series of personal contact.
Karzai is an exasperating and often infuriating ally. But we are passing through a delicate moment, and it would be better for the United States and the world if Obama had Karzai working with him rather than at cross-purposes.
Read more Bloomberg View editorials.
To contact the Bloomberg View editorial board: email@example.com.


text:
With the US dollar in decline for the past 20 years, this step-by-step guide to foreign investing--written by investment experts--is more timely than ever. Covers foreign currencies that have outperformed the dollar, starting a Swiss bank account, getting 20-30% return on foreign CDs, and more.
Genre: Business & Economics
On Sale: August 1st 1993
Format: Trade Paperback


text:
Quick links to artilces
Is Your Teen Using?
Marijuana and the Teen Brain
Virtual Tour of the Brain
Weaning a teen off pot can be a challenge
Child & Youth Counselling
Children and youth who are experiencing social, emotional and/or relationship difficulties will benefit from the Child & Youth Counselling Program. Counsellors believe that all children and youth need a connection to family or other positive role models to help them mature. This link is vital in order to provide guidance, direction and nurturing. Supporting children and youth will in turn lead to healthy relationships and mature adults. Counsellors realize the needs and concerns children and youth are much different than those of adults and support will include measures to deal with these differences.
The goals of the Child & Youth Counselling Program are to support and assist children and adolescents:
In adjusting to changes in family life or structure
In coping with difficult emotions and situations at home and at school
In reconciling relationships with their parents and/or extended family
In their transition from home to independence
Living in crisis situations in order to minimize disruption to their lives.
The Child & Youth Counselling Program is available to young people living in Kingston, Frontenac, Lennox & Addington. United Way funding allows K3C to offer this program to youth and their families at an affordable rate. Group sessions are also available.
K3C's Child and Youth Program welcomes referrals of adolescents aged 13 to 25 who are dealing with concerns related to school, family, sexual orientation, addiction, depression and stress. Our male and female counsellors have a wealth of experience addressing these issues.
K3C is pleased to announce that Brian Howell RSSW has returned to the agency's Child and Youth Program after a brief absence.
Brian is well known in the community for his years of service to adolescents and also parents of teens.


text:
(Ms. Murray has been advocating that the Liberals join forces with the NDP and the Green Party in the next election, and she has avoided direct attacks on other candidates.)
Mr. Trudeau: "Do I want to be that pointed, to talk about positive campaigns? Because in this context, people might see this as a dig at Marc [Garneau, who has been critical of Mr. Trudeau's lack of experience], and I don't necessarily want to highlight that. I don't want to necessarily even engage – I don't think I need to."
The Pierre paradox
It's an undeniable plus for a politician when much of the country literally remembers the day you were born. It was Christmas day, 1971; Pierre Trudeau was still Prime Minister, still married to Margaret Sinclair, and they were both global media darlings. To many Canadians, the Trudeau boys – Justin, Alexandre and Michel – were something like family.
After getting his education degree and teaching at West Point Grey Academy in B.C., Justin Trudeau leapt back into the public eye in the fall of 2000, when he gave a stirring eulogy at his father's funeral.
The moment was a bit like Barack Obama's at the 2008 Democratic Party convention – a single speech that creates great expectations – and Mr. Trudeau is not unaware of the parallel: In many ways he wants to do for the Liberals what Mr. Obama did for his own party.
But in Mr. Trudeau's case it also gave the sense that he was inheriting his father's mantle, a legacy about which Canadians – especially in Quebec and the Western provinces – are sharply divided.
The question is whether the reinvention of the broken Liberals as a 21st-century party really can be led by the golden child of its past.
Anyone who wants to vote for the leadership, party member or not, has to sign up by the end of this weekend. When the figures are released showing how many supporters each campaign has collected, it might reveal whether Mr. Trudeau really is unstoppable.
Downplaying the sense of dynasty, he likes to portray himself as an underdog, saying the Liberal brass didn't really want him in Ottawa and didn't help him become the party's candidate in the riding of Papineau in 2008.
In 2011, he held on in the face of the NDP's Orange Wave. On the road, he tells the grim joke that at least the Liberals, now down to 35 MPs in Ottawa, are guaranteed at least one seat – "because I won't lose my riding of Papineau."
Brand Gen X wants no squabbles
Mr. Trudeau has distanced himself from the fights that undermined the Liberal Party over the past decade. His campaign team is basically stripped of veterans of the Jean Chrétien-Paul Martin wars, including Liberal stalwarts who had wanted to be front and centre.
Instead, its core are people in their 30s and 40s whom Mr. Trudeau touts as friends, chief among them Mr. Butts and his campaign organizer, Katie Telford. It's not a coincidence that they both got their political grooming not in Ottawa but at Queen's Park in Ontario.
Mr. Trudeau's political career basically began when he was 19 and met Mr. Butts at McGill University – they had height (over six feet) and Habs fandom in common, but very different backgrounds, since Mr. Butts was the son of a coal miner from Cape Breton.
"Gerry is my best friend," Mr. Trudeau says in an interview at the Champlain Mall in Brossard, Que. "He and I have been talking about the possibility and the potential of politics all my life."
Mr. Butts left his position as Canadian president of the World Wildlife Fund to work on the race. "Justin and I are both very traditional philosophical liberals," he says in an interview, "in that the individual is paramount and government ought to be in the business of expanding opportunities for individuals."
Politically, they draw their lessons from the victories of Mr. Obama, who came to power at the age of 47, and Tony Blair, who took over at 10 Downing St. at 43. Those campaigns show, Mr. Butts says, that the traditional levers of government have become ineffective and the only way to make change is to "develop and maintain a national, grassroots, volunteer movement."Report Typo/Error
Follow @danleblaon Twitter:


text:
Reset My Password
This will send a password reset to your email address on file. A reminder that your email address on your account must be valid and working to receive the reset request.
We would love to hear your feedback and any suggestions you may have for our new VWVortex store.
Let us know if there is a color option you would like added or a particular merchandise item you would like to see in the store. Have you had a chance to buy an item from our store? Then we want to hear what you think about the merchandise you bought.
If you would like to provide feedback/suggestions please post in here in the Store Feedback forum.
Autoguide.com has published a few more photos of that Q7 pickup that popped up a few weeks back and raised some eyebrows in the blogosphere. Autoguide says they initially thought the car was a photoshop, but now believe it's real... though perhaps a re-bodied VW Amarok pickup truck.
So What Do We Think?
We've always thought the Q7 pickup was real, and have never thought it to be


text:
Reputable Beagle Breeders For Responsible Owners
This website aims to put responsible buyers in touch with reputable, small scale, exhibitor breeders of Beagle puppies and to help potential Beagle puppy buyers, differentiate between them and breeders with more commercial interests.
There are larger, well known Beagle Show Kennels (with their own websites) who's good reputation speaks for themselves.
In order to appear on this website, breeders must adhere to and maintain the high standards detailed on the "Setting The Standard" page. Before you decide to welcome a Beagle puppy into your family, you will probably have already extensively researched the breed, and all reputable breeders will be happy to spend time discussing Beagles with you.
Below are links to very useful websites which are full of valuable information about Beagles.


text:
Embers Elementary is a private, independent school, rooted in
the Catholic Faith,serving grades Pre-Kindergarten through Fifth
grade. Embers is committed to the pursuit of academic excellence
and character formation. Embers works in partnership with parents,
who are the primary educators of their children. Embers sees each
student as a child of God and a gift from God and helps them to
acquire knowledge, develop skills, and practice moral behavior.
Embers is located in Park Ridge and has an open admissions


text:
Subscribe to Email Updates:
SpaceX Scrubs CRS-3 Launch Due to Helium Leak
At 3:39 pm EDT, SpaceX's launch director stated that the planned 4:58 pm launch of CRS-3, the company's third operational cargo mission to the International Space Station (ISS), was scrubbed for the day. The next launch opportunity is Friday, but the weather forecast is iffy that day.
As many people tuned in to NASA TV at 3:45 pm EDT to listen to live launch coverage, the NASA announcer said that launch had just been scrubbed and replayed the SpaceX announcement from minutes earlier. The speaker identifies himself as the LD -- launch director -- and says "We have encountered an issue that will result in our scrubbing today's 4/14 launch attempt."
SpaceX soon posted a message on its website stating that the problem is a helium leak on the Falcon 9's first stage.
NASA and SpaceX earlier had stated that if the launch did not go today, the next opportunity is Friday, but an Air Force weather officer at a pre-launch briefing yesterday said the weather was only 40 percent favorable on Friday.
SpaceX says on its website that it will fix the helium leak by then, but acknowledges the poor forecast.
The launch window on Friday, April 18, opens at 3:25 pm ET.
User Comments
SpacePolicyOnline.com has the right (but not the obligation) to monitor the comments and to remove any materials it deems inappropriate. We do not post comments that include links to other websites since we have no control over that content nor can we verify the security of such links.


text: first of all i have a learning dissablitly with words and grammar so please dont't make fun cowards. i was very excited for moh warfighter. i really like the first one even though it was very short and every firefight was at long distance but one thing i loved was the physics( ragdoll) and the sometimes dismeberment it was very satisfying shooting a bad guys it was FUN. now Moh Warfighter doesn't have that its very boring shooting bad guys terrorists whatever you want to call them. its boring and i found myself just wanting to complete the story but i wasn't having any fun and sadly i don't even think ill play the campaign again for fun but for the achievements which sucks ass. it has the same problem battlefied 3 had with death animations (ragdoll) when you shot your gun the bad guys didn't react at all getting shot they just simply flop on the ground like you didn't even shoot them. but at least battlefield 3 had blood moh warfighter should of been rated teen its not even violent maybe little blood on the wall but thats it. im gonna say this Frostbite 2 engine is amazing with graphics and destruction and sound but it sucks ass with physics death animations (ragdoll) and they need to seriously work on them cause it destroys all the fun damn you guys. another annoying thing is the beautiful music by ramin dijawdi who also scored the iron man movies and clash of titans and more is so unbalanced you can only hear it on some parts or barely at all. Now the good. freaking amazing graphics amazing sound thats all perfect guns are awesome loud and reload good like they should. pretty good story some really cool moments in the game especially towards the end the car chases are friggin cool better then any driving or racing game ive played. longer then the first medal of honor 2010. lot more close quarters firefights but very boring due to fact the way people react to getting shot.BoRING. the breaches are sweet explosive and loud and gives you different options. ;{ the Multiplayer is pretty fun definetly does not look as near as good as single player there is barely any destruction i find that multiplayer is kinda of confusing how to unlock guns or when you should move on to a different class or when you reach max level on assault it doesn't really show you that. really fun firefights warfighter has some amazing audio thats for sure. its pretty sad when multiplayer is funner then the campaign. i Give Medal Of Honor Warfighter sadly 6.5 which is a shame. bottom line its just not any fun and thats what games are post to be. i would like to thank all the soliders past and present for fighting terror and keeping us free and safe god bless.


text:
|by Roberta Rankin "jellybaby"
|Date Added: Thursday 23 May, 2013
Sophie likes catnip and toys that she can kick. I've purchased several types but the cat rings may be her favorite. The reason I'm not sure is something has happened to both of them...they're missing in action. Whether she's toted them off to keep them from Tucker, tossed them so efficiently she's lost them (and I've searched without success), or Tucker has hidden them to annoy her. Beware you may need to buy an additional package if yours go "missing." :)
|by M. Warner
|Date Added: Thursday 25 April, 2013
My cat adores this toy. He's approaching middle-cat-age and this toy still brings out the kitten in him. He'll enjoy it for about 5-8 months before it's time for a new one and really, that's because he's torn the feathers out with his vigorous play and the 'fur' is all icky with drool. It's really because I feel like he needs a new one and less because he feels it's time.I love that this toy comes in a 2 pack, too. It's great for spoiling more than one cat. I like to give the second one away as a gift to friends who have cats.Worth every cent!
|by Max's Mom
|Date Added: Monday 04 March, 2013
My cat has a basket of toys, but this is by far his favorite. The mice and balls are forgotten. He is one happy boy as long as he has his "softie rings" (our name for them).
|by Susan
|Date Added: Saturday 16 February, 2013
My small dogs like cat toys, so that was the main reason for this purchase. Unfortunately, my dog chewed the antennae off the caterpillar before the cat had a chance to play with it. The antennae are little leather or leather-like strands, but they can be chewed through quite easily. Very cute toy otherwise.
|by KL
|Date Added: Monday 31 December, 2012
These toys were a success for all of the cats! They roll, they throw like a frisbee, they are soft, and smell like catnip....what more would a cat want??
|by A. BenYehuda "let's get some shoes"
|Date Added: Wednesday 19 December, 2012
My 2 kitties go absolutely nuts for the crinkle fish. I've purchased 2 or 3 2-packs for them over time and they take such delight in destroying them (since everyone knows cats like their toys even more the more scuzzy they get!!!). It's so fun to watch them come into a room, sniff the fish, and fall over on it. Definitely a favorite in this house and I will continue to purchase. Love that red and green ones are released for the holidays.


text:
Jump to:Page Content
Home > Degree Programs > Registrar > Instructions for Cross-Registration and Auditing
Harvard University students as well as MIT and Tufts Fletcher students are welcome to cross-register into HKS classes.
For Harvard and Tufts Fletcher Students:
Note: Cross-registration is not available to students outside of Harvard, MIT, and Fletcher, those individuals can only audit courses.
For MIT Students:
As of the Spring 2017 semester, MIT students are no longer be able to use Harvard's Course Catalog and Cross Registration Application to cross register into Harvard courses.
Please visit MIT's Add/Drop application site to submit your Harvard Kennedy School Cross Registration requests.
Harvard Instructors will receive an email alerting them that you are interested in cross-registering into their course. Instructors approve or deny student requests online. For updates on the Instructor's decision, please check in the MIT Add/Drop application.
You are not officially enrolled in a course until the Harvard Registrar has approved your petition.


text:
Sweetwater jazz series set to kick off in Sewickley
Kevin McManus wants to change the image of the trombone.
The founder of the Pittsburgh Trombone Project, a band that will perform the first concert of Sweetwater Center for the Arts' 10th annual Sweet Jazz Series Feb. 7, said the trombone can be a wonderful instrument when it comes to jazz music.
The band will perform a tribute to J.J. (James Louis) Johnson and Kai Winding — prominent trombonists from the 1950s through the 1970s, who first began to use the trombone as a jazz instrument and were the first ones to "put the trombone in the spotlight," McManus said.
"It's more than marching music and circus clown music," he said.
"We want to change that humorous image and show people it can play beautiful melodies."
The Swissvale resident said he founded the band five years ago. The core group includes McManus; Bob Matchette of Cranberry; Chris Carson of Donora; and James Nova of Ohio Township, all of whom play the trombone.
McManus said the group has branched out to include a rhythm section used at certain venues, such as Sweetwater.
The larger group includes McManus and Matchette, and Tom Glovier of the North Side on piano; Bob Insko, Vandergrift, bass player; and David Glover, Cranberry, drummer.
McManus, an award-winning trombonist who started lessons in 1992, has founded several bands; teaches a variety of musical instruments at several universities; has written and arranged music for other groups; toured nationally and on Broadway in the show "Urinetown: the Musical"; and performed solo in Pittsburgh Civic Light Opera's "Swing."
Among the musicians he has performed with include Aretha Franklin, Glen Campbell, Tony Bennett, the Four Tops and Josh Groban. The other members of the band — all in their 30s and early 40s — also have extensive musical histories and music educations.
You are solely responsible for your comments and by using TribLive.com you agree to our Terms of Service.
We moderate comments. Our goal is to provide substantive commentary for a general readership. By screening submissions, we provide a space where readers can share intelligent and informed commentary that enhances the quality of our news and information.
While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. We will make them as carefully and consistently as we can. Because of the volume of reader comments, we cannot review individual moderation decisions with readers.
We value thoughtful comments representing a range of views that make their point quickly and politely. We make an effort to protect discussions from repeated comments either by the same reader or different readers
We follow the same standards for taste as the daily newspaper. A few things we won't tolerate: personal attacks, obscenity, vulgarity, profanity (including expletives and letters followed by dashes), commercial promotion, impersonations, incoherence, proselytizing and SHOUTING. Don't include URLs to Web sites.
We do not edit comments. They are either approved or deleted. We reserve the right to edit a comment that is quoted or excerpted in an article. In this case, we may fix spelling and punctuation.
We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly.
We appreciate it when readers and people quoted in articles or blog posts point out errors of fact or emphasis and will investigate all assertions. But these suggestions should be sent via e-mail. To avoid distracting other readers, we won't publish comments that suggest a correction. Instead, corrections will be made in a blog post or in an article.


text:
Versal 6 is now available! This journal out of Amsterdam contains my poem, "This small poem." It is my second internation publication and it is one I'm very proud of. So, if you're in a good bookstore, look for Versal. If they don't carry it, tell them they should. Here's the full list of contributors to this issue:
Wiljan van den Akker, Shifa Ali, Larissa Andrusyshyn, Matt Anserello, Jennifer Arcuni, Jenny Arnold, Rane Arroyo, Tom Bass, Ewan Cameron, Logan Chace, Selfa Chew, Lakey Comess, Francisco Cunha, Marosa di Giorgio, Joris Diks, Ben Doller, William Doreski, Magdolene Dykstra, Carolina Esses, Magdalena Ferreiro, Ana Fornaro, Anthony Frame, Lara Frankena, Dana Gentile, Ericka Ghersi, Cynthia Grier Lotze, Marilyn Hacker, David Hart, Derek Henderson, Takashi Hiraide, Rozalie Hirs, B.J. Hollars, Sandra Jensen, Andrew J. Jones, Toshiya Kamei, Sándor Kányádi, Michael Karman, Nabil Kashyap, Ko Kooman, Dawn Lonsinger, Rachel Marston, David Miller, Kelly Moffett, Jane Monk, Emmanuel Moses, Jennifer D. Munro, Mace Murakishi, Sawako Nakayasu, Alistair Noon, Emelie Östergren, Miroslav Paral, María Cecilia Perna, Alex Piperno, Jeannine Marie Pitas, Amy Purifoy Piazza, David Ruhlman, Danielle Smits, Paul Sohar, Julian Stannard, Jean Tripier, Xiao Kaiyu.
I've been looking through it and I have to say it is killer collection of poems, stories and the coolest, weirdest artwork I've seen in a long time. And one of the mazing things is that my good friend and former teacher, Rane Arroyo, is included in the issue too. And we're only separated by a few pages. It's weird to have my poem nearly next to my poetry professor's poem.
And, as if this whole experience wasn't cool enough, the issue was accompanied by a postcard from the journal's poetry editor. Now, to give context to this postcard, though the editor had no idea of what I am about to say, you need to understand that my small poem is literally a small poem -- it is two, two line stanzas. So, including the stanza break, it is only five lines long. But it is surrounded by these three page poems and seven page short stories. And I'm not exactly a famous poet so, all in all, I had insecurities about being in the journal. But then I read the postcard:
So, not only am I incredibly honored to be a part of the Versal family, I can easily say, without a doubt, that this has been the most positive and enriching publishing experience I've ever had.
So, again, go to your favorite bookstore and look for Versal. If they don't have it, tell them to subscribe because journals like this need to be supported.
[end of post]


text:
Browse by Medical Category
Accepting New Patients
Dr. Herndon is a leading orthopaedic surgeon, educator and researcher who has made important advances in orthopaedic surgery, education, professional leadership, and patient safety.
Go To Programs
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Edit Profile
Dr. Herndon has a special interests in degenerative diseases and trauma reconstruction of the upper extremity. He has published more than 200 papers, five books and 31 book chapters. Dr. Herndon is a frequent lecturer at scientific meetings around the world and led the first clinical trial using gene therapy for rheumatoid arthritis.
Dr. Herndon received his MD from UCLA in 1965 and completed his orthopaedic residency in 1970 at Children's Hospital and Mass General Hospital in Boston. From 1971 to 1973, he was a major in the US Army, serving as Chief of the Amputee Service at Valley Forge General Hospital in Phoenixville, PA. He then completed a fellowship in reconstructive hand surgery in 1974 at Roosevelt Hospital in New York City.
Dr. Herndon has the unique distinction of having served as President of all important Orthopaedic Societies: American Academy of Orthopaedic Surgeons, American Board of Orthopaedic Surgery and American Orthopaedic Association. He also served as chairman of the Residency Review Committee for Orthopaedic Surgery.
Prior to joining MGH in 1998, Dr. Herndon was Professor and Chairman of Orthopaedic Surgery at the University of Pittsburgh Medical Center from 1988 to 1998 and Professor and Chairman of Orthopaedics at Brown University from 1978 to 1988. He has held additional academic appointments at the University of Pennsylvania School of Medicine, Columbia University College of Physicians and Surgeons, and Michigan State University.
Dr. Herndon also holds a MBA in health care management from Boston University. He has received honorary degrees from Brown University, Harvard Medical School and Loyola-Marymount University. Recently, Dr. Herndon was elected an Honorary Fellow of The Royal College of Surgeons of England.
Dr. Herndon has made significant contributions in general orthopaedics, including adult respiratory distress after fractures, fat embolism with total hip replacement, management of war-injured amputees, scoliosis, as well as in hand and upper extremity, including arthritis, joint reconstruction, tendon and nerve injuries, and congenital problems.
Dr. Herndon was a pioneer in gene therapy for rheumatoid arthritis and led the first gene therapy clinical trial in the US. His other research interests include biomechanics of the forearm and the interosseous ligament, tendon injuries, and nerve healing.
Dr. Herndon continues to be interested in quality of care, especially regarding patient safety and the reduction of medical errors.
Select Publications:
Herndon JH, Allan BJ, Dyer G, Jawa A, Zurakowski D. Predictors of success on the American Board of Orthopaedic Surgery Examination, Clin Ortho & Related Research. 467:2436-2445, Sept. 2009.
Wong D, Lewis B, Herndon J, Martin C, Brooks, R. Patient safety in North American: beyond "Operate through your Initials" and "Sign your Site". J Bone Joint Surg Am. 91:1534-41, 2009.
Wong DA, Herndon JH, Canale ST, Brooks RL, Hunt TR, Epps HR, Fountain SS, Albanese SA, Johanson NA. Medical errors in orthopaedics: results of an AAOS member survey. J Bone Joint Surg Am. 91:547-557, 2009.
Huddleston J, Maloney W, Verzier N, Wang Y, Hunt D, Herndon J. Adverse events in total knee arthroplasty. A national Medicare study. Journal of Arthroplasty, 24:Issue 2, Feb 2009.
Lieberman I, Herndon J, Hahn J, Fins JJ, Rezai A. Surgical innovation and ethical dilemmas: a panel discussion. Cleveland Clinic Journal of Medicine, Volume 75, Supplement 6 S13, 2008.
Back to Top


text:
The Best Science Fiction Book (series) you've read
View Single Post
April 11th, 2008, 02:28
I read a lot of sci fi in HS, all the classics.
and Asimov's
trilogy and the Robot series are great books in any genre. I don't read as much of it now, but some books stick in your mind and refuse to be left behind--
The Lathe of Heaven
--Ursula K. LeGuin
Stranger in a Strange Land,The Cat Who Walked through Walls
--Robert Heinlien
series-starting with
Nine Princes in Amber
, I believe, by Roger Zelazny--also that crazy one he wrote about the Hindu gods-
Lord of Light
??--title escapes me atm…
Slaughterhouse Five, Welcome to the Monkey House, God Bless You, Mr. Rosewater, Player Piano
--Kurt Vonnegut
Of newer stuff, I recently read
The Algebraist,
by Iain Banks--reminiscent of Vonnegut to me, and very good.
And a few sci-fi fantasy hybrids--
I always recommend Valerie Leith's
Company of Glass
trilogy--a bit convoluted at times but some interesting if occasionally long-winded philosophy under the sci-fi fantasy hood.
I like Barbara Hambly's older stuff, too--the Darwath series including
Icefalcon's Quest, Mother of Winter,
etc, the standalone
Bride of the Rat God
(a bit satirical) and the
ones, though
, the last, is extremely depressing.
Death of the Necromancer
--Martha Wells--great theivery and high fantasy, pretty well written.
The Bone Doll's Twin
--Lynn Flewelling--great dark fantasy with some occasional gruesomeness, also pretty well written. This is part of a series but I've never caught the rest of it.
But these are closer to fantasy, not sci-fi.
Where there's smoke, there's mirrors.
Last edited by magerette; April 11th, 2008 at
. Reason: grammar
Join Date: Oct 2006
Posts: 7,929
View Public Profile
Send a private message to magerette
Find More Posts by magerette


text:
The release last week of the first numbers from the 2010 Census underscores even more than usual the importance for all Americans, and especially Americans of color of heeding the nationwide redistricting process about to get under way. As the U.S. Census Bureau releases more data in February and March, state legislatures will begin redrawing the boundaries of their political districts – a process that will be heavily influenced by population shifts. The new Census numbers show the effect such shifts and growth in population can have.
For example, the new numbers show an acceleration of the shift in the growth of the population from the Northeast and Midwestern parts of the country to the Southeast and western regions. The list of states which have won or lost Congressional seats because of the population shifts tell the tale. Seven of those ten states that will lose one or two Congressional seats are in the Midwest or Northeast. The eight states that will gain seats are in the Southeast or the West; Texas, whose population grew by more than 20 percent, will gain 4 new representatives in Congress.
Overall, the American population grew by roughly 10 percent, from 285 million to more than 308 million. That growth was fueled by the increase of Latino Americans, from 36 million to 47 million. The Asian-American population grew from 11 million to 14 million, white Americans from 230 million to 244 million, and African Americans, from 36 million to 39 million.
To help African Americans and other minorities prepare for the redistricting process, the NAACP Legal Defense and Educational Fund (LDF) has launched a redistricting preparedness initiative that aims to heighten awareness and encourage participation in the process. The Redrawing the Lines initiative includes a public education video and website that can be found at www.redrawingthelines.org [3]. In addition, LDF has joined with the Mexican-American Legal Defense and Educational Fund (MALDEF), and the Asian American Justice Center (AAJC) to produce "The Impact of Redistricting in Your Community." [4]The booklet is a guide that aims to empower communities of color to play a meaningful role in upcoming local, state and congressional redistricting efforts.
[1] http://www.naacpldf.org
[2] http://www.naacpldf.org/case-issue/redistricting
[3] http://www.redrawingthelines.org
[4] http://naacpldf.org/files/case_issue/Impact%20of%20Redistricting%20in%20YOUR%20Community%202010.pdf
[5] http://twitter.com/home?status=Currently reading http://www.naacpldf.org/news/census-numbers-underscore-importance-redistricting-process
[6] http://www.facebook.com/share.php?u=http://www.naacpldf.org/news/census-numbers-underscore-importance-redistricting-process
[7] http://digg.com/submit?phase=2&url=http://www.naacpldf.org/news/census-numbers-underscore-importance-redistricting-process&title=Census+Numbers+Underscore+The++Importance+of+the+Redistricting+Process++
[8] http://del.icio.us/post?url=http://www.naacpldf.org/news/census-numbers-underscore-importance-redistricting-process&title=Census+Numbers+Underscore+The++Importance+of+the+Redistricting+Process++
[9] http://www.naacpldf.org/printmail/news/census-numbers-underscore-importance-redistricting-process
[10] http://www.naacpldf.org/print/news/census-numbers-underscore-importance-redistricting-process


text:
One of the beauties of Team Challenges is that they are portable. Going camping for the summer? You can easily pack some basic challenge materials and add team building to your campfire activities (putting up the tent also qualifies!).
But what if you don't have the room or the desire to pack a roll of masking tape and toothpicks? Never fear! I've got you covered. First, you will need to send the team on a scavenger hunt to find the following items*, but don't tell them what the challenge will be.
22 sticks, about as round as a pinkie finger and a foot long
10 rocks as big as a fist
10 large leaves
5 pine cones
a handful of moss
25 small stones
Build a Tower that Won't Topple
Using the materials you gathered, build a structure that will hold as many of the small stones as possible at least 15" above the ground. You may not use any of the small stones as part of your tower. You have 1 minute to make a plan without touching the materials and 5 minutes to build the structure. Once your structure is complete - or at the end of the five-minute building time - choose a team member to place the small stones onto the structure one at a time.
You will receive up to ten points each for creativity, communication, and cooperation. Plus, for every 5 stones that stay on the structure without toppling it, you'll get 5 points.
*I am making a grand assumption that you will be camping in an area where all of these items will be available. If not, here's YOUR chance to get creative. What's on hand that you could substitute?
Did you try it? Snap a photo and I'll share it here!
Subscribe to: Post Comments (Atom)


text:
Redford, MI, USA < change city >
Florists (69)
DJs (65)
Cakes (62)
Bands (53)
Wedding Day Beauty (48)
Caterers (43)
Limos (32)
Rentals (30)
Coordinators (27)
Wedding Fashion (26)
Officiants (19)
Decorations (18)
Invitations (17)
Videographers (16)
Photo Booths (13)
Ceremony Sites (319)
Reception Sites (177)
See All Vendors >
DEARBORN WEDDING IN SEPTEMBERSeptember, 2011 in Dearborn
We'll email them to see if they can answer your question.Requires Login
You must log in before you can send this couple a question. Log in here.
If you do not have an account, you can register a new account here.
We do this to ensure that the couple does not get emailed needlessly.
Ceremony: Courtyard Ceremony: The Henry Ford Museum
Reception: Reception: The Henry Ford Museum
Requires Login
You must log in before you can save anything to your wedding notebook Log in here.
If you do not have an account, you can register a new account here.
- Cakes/Candies Vendor: Fox and Hounds Pastry-West Bloomfield
- Photo Booth Vendor: Shutter Booth
- DJ: Mike Staff Productions
- Photographer: Silver Thumb Photo
- Florist: One Enchanted Evening
- Wedding Fashion Vendor: Bridalgown.net
- Invitations Vendor: My Gatsby
- Ceremony: Courtyard Ceremony: The Henry Ford Museum
- Entertainment: MGM Grand Casino
- Reception: Reception: The Henry Ford Museum
- Attraction: Detroit Institute of Arts
- Hotel: Hyatt Regency Dearborn-Detroit
- Attraction: Eastern Market
- Hotel: The Dearborn Inn, A Marriott Hotel
- Oh no! I forgot... (aka SHOPPING!): Birmingham Shopping District
- Restaurant: Greektown
- Oh no! I forgot... (aka SHOPPING!): Fairlane Mall
Cakes/Candies Vendor:
Fox and Hounds Pastry-West Bloomfield4301 Orchard Lake Rd # 155
West Bloomfield Township, MI, United States
"We weren't big cake people, just wanted something unfussy that tasted good. The cake was DELICIOUS! we got several complements and it was perfect. it tastes better because they don't use fondant, it's all buttercream frosting (the designs are less specific though if that's what you're looking for)."
Mike Staff Productions1934 Livernois
Troy, MI 48083, USA
"Our DJs were very friendly and nice, but didn't facilitate the evening super well, we had to keep prompting them to either move to the next step and/or play more fun music (we did go over types of music to play ahead of time, but it didn't seem like they were playing any new songs unless we specifically asked them, so we would have to go up to the dj every few songs). that being said, got a great deal and have heard great things, just recommend being VERY specific during the interview stage."
One Enchanted Evening2613 Collendale
Commerce Twp, MI 48382, USA
248 685-9281
"A+++! Cannot say enough good things. They were awesome."
Invitations Vendor:
My GatsbyFremont, CA, USA
"I made my invites through my gatsby (the printed inserts) and "cards and pockets" (the pocketfolds and envelopes) both turned out perfectly! for inspiration, the weddingbee blog has great examples of invites!"
Photo Booth Vendor:
Shutter BoothPO Box 1082
Royal Oak, MI 48068, USA
"this vendor was a last minute add on and they were great! they send you electronic copies of everyone's photos, along with the hard copy book they make you. they also work to make sure that they get pictures of everyone you want to get in the book, as well as some of the bride/groom. all of the guests LOVED this (be warned: the dance floor will be thin at times while everyone's at the photobooth!)"
Silver Thumb Photo110 West Liberty Street
Plymouth Charter Township, MI, United States
"A+++ vendor. Tamara is unbelievably talented, professional, responsive, and creative. She is just as excited as the couple getting married and wants to make the pictures as amazing as possible. She had great ideas and we got some amazing shots. Her assistant was also great, and having both covered different angles of the same events. Also, she worked with us on tailoring a package."
Wedding Fashion Vendor:
Bridalgown.netDearborn, MI, USA
"got a great deal on a designer gown that i tried on at a store but couldn't afford retail. website is not super user friendly (try on dress first) and responsiveness to emails and inquiries was so/so, but overall had a great experience and recommend this website. Also, the dress does take awhile to come in! Mine came a few weeks later than quoted, be sure to factor that in!"
Courtyard Ceremony: The Henry Ford Museum20900 Oakwood Blvd
Dearborn, MI 48124
Reception: The Henry Ford Museum20900 Oakwood Blvd
Dearborn, MI 48124
"We absolutely LOVED the venue, but I have to give them 3 stars because we had some issues with our wedding coordinator. The coordinator did not disclose that they were undergoing construction, they were not understanding of any concerns we had regarding the construction and other issues. The wedding coordinator was VERY rude to me and my family on the day of the wedding when we were trying to figure out if we were using the rain venue. When I called after the wedding (very politely) to let the coordinator's manager know what happened, she did not want to hear it and offered no solutions, telling me the entire thing was in my head (even though I had random wedding guests coming up asking me who that woman was who was so rude to my mother before the ceremony). The venue itself is awesome, and the waitstaff were amazing (especially the woman who takes care of the bride/groom all night) but the interaction with the coordinator throughout the months leading to the wedding, and on the day of, sort of soured the whole thing for us."
Hyatt Regency Dearborn-Detroit600 Town Center Drive
Dearborn, MI, United States
The Dearborn Inn, A Marriott Hotel20301 Oakwood Boulevard
Dearborn, MI, United States
"awesome place to house you and your guests. great atmosphere and the bar downstairs is a great gathering place for the wedding party and friends after events."
Greektown400 Monroe St
Detroit, MI 48226
MGM Grand CasinoMGM Grand Detroit Casino, 1300 John C Lodge Fwy
Detroit, MI 48226-2414
Detroit Institute of Arts5200 Woodward Ave
Detroit, MI 48202
Eastern MarketEastern Market, Detroit, MI
Detroit, Michigan, US
Oh no! I forgot... (aka SHOPPING!):
Birmingham Shopping District151 Martin St
Birmingham, MI 48009
Oh no! I forgot... (aka SHOPPING!):
Fairlane Mall18900 Michigan Avenue
Dearborn, Michigan, United States


text:
Atrosan is a traditional herbal medicinal product used for the relief of:
1 film-coated tablet contains 480 mg of extract (as dry extract) from Devil's claw root (Harpagophytum procumbens D.C. and/or H. zeyheri L. Decne.) (1.5-3.0:1). Extraction solvent: Ethanol 60% V/V. The other ingredients used for the tablet are lactose, maize starch, microcrystalline cellulose, precipitated silica, colloidal silica and magnesium stearate (vegetable source). The tablet coating contains talc, titanium dioxide, macrogol and hypromellose.
Directions for use:
Adults and the elderly: Take one tablet twice daily immediately after food. The dose can be increased to two tablets twice daily if relief is not obtained after 3 to 5 days.
Not for use in children or those under 18.
For oral use only. Read leaflet before use.
Do not use if you are allergic to Devil's claw or any of the other ingredients. This product contains lactose.
Keep out of the reach and sight of children.
Warning: Always read the label and keep out of reach of children.
Any Product sold or supplied by Bodywiseuk.com are not intended for the treatment,
prevention and cure of any medical conditions.
Never exceed recommended intake unless professionally advised.


text:
Re: Tire Choices for STOCK sizesOriginally Posted by thebigjimsho
FYI, I've done way more performance mods to my GTO than appearance mods and I do them all myself. If you've been looking at my site I mainly post the appearance mods because that's what people want to see. A pic of a cam or heads going in doesn't get looked at I know.
I never said anything bad about the Sports performance, in fact I said they were good, just ugly. Some people will like them, but the majority of people who don't even notice tires will see they stand out and call them ugly, sorry I've seen it first hand.
I'll drop this since I've obviously hit a nerve, sorry for saying what I've seen first hand.16 ATS-V | 12 CTS-V | 12 SRX | 05 CTS-V (sold)
Re: Tire Choices for STOCK sizesOriginally Posted by AmesCTS-V
In no way was that post a slight to you. Just your self-confidence.
Re: Tire Choices for STOCK sizes
I was the only one talking with you about it so I had to assume it was directed at me. At car shows I usually pay more attention to what the non-car people say, like the wives and regular joe's that show up. The car guys tend to be into the bling or old school, rarely middle of the road.
I personally keep my opinions to myself at car shows when I don't like something. But, a nice burn out would be a good response to someone ripping your ride.16 ATS-V | 12 CTS-V | 12 SRX | 05 CTS-V (sold)
- 06-23-05 10:11 AM #79Cadillac Owners Enthusiast
- Join Date
- Feb 2004
- Posts
- 590
Re: Tire Choices for STOCK sizesOriginally Posted by thebigjimsho
I guess if two tires had near identical performance, you might decide on which design you prefer... but replacing or choosing tires based on tread pattern - you must be kidding.
Point in case, I have GS-D3s and personally dislike the V pattern... but they met my criteria for performance, and that was that. BTW, I like the look of Michelin tires.
Re: Tire Choices for STOCK sizes
I need some pretty tires. Hoping to have a custom shop convert some GY RSA's into Vogues. :coolgleam This way I have the superior performance of RSA's and the look! Please don't be playa' haters.
- 06-23-05 08:29 PM #81Cadillac Owners Connoisseur
- Automobile(s): 2016 ATS-V
- Join Date
- Feb 2004
- Location
- Calif.
- Posts
- 2,261
Re: Tire Choices for STOCK sizes
And let's not forgot the BFG Scorcher... which came in all the popular gang colors...
Re: Tire Choices for STOCK sizesOriginally Posted by Dreamin
Re: Tire Choices for STOCK sizesOriginally Posted by CVP33
- 07-28-11 11:05 PM #84Cadillac Owners Fanatic
- Automobile(s): 05' CTS-V Platinum
- Join Date
- Jul 2011
- Location
- South Carolina
- Posts
- 137
Re: Tire Choices for STOCK sizes
As a newbie to this forum I need to start posting. This conversation is right up my alley since I work for Michelin.... Yes a little biast, but I also see the raw data from testing. The new Pilot Sport is amazing! It was the first upgrade I did to mine. Its all about bang for the buck though right?
- 07-29-11 11:12 AM #85Cadillac Owners Fanatic
- Automobile(s): 2005 CTS-V
- Join Date
- Apr 2008
- Posts
- 168
Re: Tire Choices for STOCK sizes
This thread was 6 years old. Ironic you found a 6 year old thread on tires to reply to and you just happen to work for a tire company?
I'm not sure about the forum rules on pushing products, but I'm sure there are more current, relevant tire discussion threads that could benefit from some biased contributions.
- 07-29-11 11:52 AM #88Cadillac Owners Fanatic
- Automobile(s): 07 cts-v
- Join Date
- Sep 2009
- Location
- N. Texas
- Posts
- 293
Re: Tire Choices for STOCK sizes
OK I'll assume that resurrecting this thread can work for real discussion and not scamming, so here goes my 2 cents worth...
I bought a used 2007 with about 20k miles on it. The dealer replaced the rear tires because they were worn, but the front tires looked OK so they kept them. (I can't think of why the rear tires would be worn more than the fronts ). The car came with RS-A's and they put RS-A's back on it. The fronts lasted just past 30k miles. I replaced them with Continental ExtremeContact DWS. (And no I don't work for any kind of tire-related company.)
So far so good with the Contis, and my RS-A's on the back are at 20k miles and still have a lot of tread left. (I know what you're going to say because I've already heard it. ) Not long after I got the car I made the decision to go away from run-flats so I bought a spare on this forum and bought a jack on ebay. And actually when one of my original RS-A's went flat on a trip I just put my spare on and went about my business, then bought the Contis when I got back into the big city.
I've got "tire envy" now that I see that the new Camaro comes with 275 width tires on the back.
Wide tires are nice, but imo proportion/balance/stance are important to the overall look of a car, to the extent that too wide a tire can look goofy.
The cts can pull it off, but its a narrow/tall car. Lowering is a key addition to the equation.
Re: Tire Choices for STOCK sizes'05 CTS-V, Maggie, Kooks, Hotchkis, Ground Control, Corsa, B&M, DSS/Hendrix, Full 3M Clear Bra, Autovation, V Headrests, CTS Console, STS-V 55w Fogs, Black Vette FRCs, Specter Werkes, Katech LS9 Clutch, SS Brake Lines, Heavymetals U-Turn Fuel Line Eliminator, Momo Combat Evo Shift Knob, Wldwhl Clear Sidemarkers, Linea Corse LC855 Wheels, plus a couple more. Mustang dyno'd at 472 RWHP/411 RWTQ.
- Sponsored Links Remove Advertisements


text:
Costume Photos
Costume Information
|Just need an event excuse to wear this now >:D
This looks brilliant! :D
Loving the Tifa cosplay, I think I may have seen you at expo!
@Charlie- Thanku! ^^
@emily- Hehe thanku, yeah I remember seeing ur Lucy cosplay! :D
Ohh it's good to see others doing this version of tifa to ^^ great work, you look lovely, i wish i could of grabbed a picture with you as dead aerith XD
You look great hun. Shame I didnt get to see this at expo >.< Damm!!
You look soooo awesome...nice job ^_^
@tif9123- dead fantasy certainly needs more lovin ^^ aww that would have been great to get a picture *o* ur dead aerith was amazing!
@Bambi- aww i knows >o< but thanku ^^
@Rinoa- hehe thanku :)
Looking really awesome ;)
Hehe thanku :D
this looks ab fab :D
^o^ thanku!
Best DF Tifa Ever! =D x.
This awesome! You really suit her~
This is fantastic! I can't believe I've never seen it before!
Thanku :3
Looking Awesome


text:
Tag Archives : Renault
Renault puts new car launches on hold in India
The French car manufacturer Renault, who presently sells the Logan with a tie up with Mahindra, has delayed its plans to launch new car models.
Hyundai's low cost car simple and more functional; m badges for i20 and i30 MPVs
Korean carmaker Hyundai has made grand plans to rival Japanese car major Toyota's iQ. The iQ is among the smallest cars you can buy off.
2009 Nissan 370Z- Advertisement, India Price and Specifications
The 2009 Nissan 370Z is the first full redesign of the iconic Nissan 350Z since its introduction in 2003. The new model builds on the.
Mahindra Renault refuses to supply Logan to Mumbai taxi drivers
Mahindra Renault Logan- when you think of this name, space, space and more space comes to your mind- Why, it's India's firse wide body car..
Skoda Superb Parking Assist bags Sky Motoring Best Gadget Award
The new Skoda Superb has received yet another award in the form of Sky Motoring's Best Gadget honour. Skoda's innovative Parking Assist beat opposition from.
Low Cost Brand from Fiat for Europe- Possible partnership with Tata Motors
Italian car maker Fiat is planning to launch a new low cost brand in Europe and bring to the market, three models under a new.
Video- Renault's V6 dCi Diesel engine
French Automaker Renault recently unveiled a new V6 diesel engine. A V6 diesel engine might never find its way into Renault's Indian offerings, but it.
Renault is designing Bajaj's low cost car
[singlepic=160,320,240,,] French manufacturer Renault Motors is designing the entry-level low cost car (codenamed ULC) that it going to be rolled out jointly with Nissan Motors.
Renault Sand'up based on the Dacia Sandero
Renault knows how to spawn multiple cars from the same platform. Have a look at their upcoming cars- the Sandup based on the Sandero's platfrom.
Eye Candy- Renault R28 F1 car at 2008 IIT Shaastra
Indian Autos Blog wish to thank Arjun from Chennai for sending us these snaps. ING was one of the key sponsors for IIT Shaastra, an.
Renault Logan Sport Version- Wow!
OK. Don't get very excited as this car ain't for India. It's the Logan Sport which will be sold in Brazil. The car it seems.
Introducing The All New Renault Sandero Stepway
Introducing the all new Renault Sandero Stepway which will be launched in Brazil by this October and Argentina will follow soon. The car, which will.
Bajaj's low-cost car to be a rebadged Nissan and Renault elsewhere
After Tata announced that it was open for talks with Fiat to sell the Nano globally, Bajaj says it too will adopt the same path.


text:
- This question is currently being edited.
General Question
Asked by MarcellusMeshell (4) May 11th, 2014
Alpha Fuel X has a long history in South America. I know a myriad of coworkers will find a great deal from Alpha Fuel X and it details it all. The body building industry has millions of practitioners all over the world and each of them has a claim to know the fastest way to build muscle.
Observing members: 0 Composing members: 0
1 Answer
This discussion is closed.
Wow! You've got 847 knowledge matches!Want to see them? Join Fluther!


text:
Car soap and other cleaning products
View Single Post
Officially Welcomed to the 'Fest
Location: San Diego, CA, USA, Earth.
Join Date: Oct 2012
Posts: 241
Mein Auto: 2013 X3 28i
View My Garage
I love Meguiar's Gold Class, it makes your paint fairly shiny even without wax. Don't use soap that also contains wax, wash and wax should be two separated processes for the best result.
I think good
washing and drying techniques
are much more important than the product brand you choose ( search some youtube videos ). The goal is not to scratch or create swirls on your clear coat. One important thing that lots of people don't know is to damp your drying towels with lubricant, such as Meguiar's ultimate quik detailer, so if your towel pick up any dirt you miss from wash it will less likely to damage the clear coat.
Attached Thumbnails
View Public Profile
Find all threads started by edbiology
Find all posts by edbiology
View My Garage
Add edbiology to Your Ignore List


text:
ASTM to Develop Certification Programs
ASTM International's board of directors has voted to authorize the organizaiton's management to develop the capability to offer certification services. Titled the ASTM International Certification Programs, the new initiative is sponsored by ASTM International and offers the opportunity for certification of products (materials, products, services and systems) as well as personnel.
The recent action by the ASTM board is a response to inquiries, particularly in the areas of new standards development activities, for ASTM to provide certification to meet expressed needs for independent, third-party demonstrations of compliance to standards, officials state. Similar requests have come to ASTM from those facing regulatory pressures to demonstrate standards compliance.
"The board agreed that the ability for the society to offer certification programs as a part of ASTM's portfolio of services—similar to our successful proficiency testing and training programs—is important in remaining relevant in the changing global marketplace," explains James A. Thomas, ASTM International president. "This is the first step toward certification in ASTM's 111-year history. The board approved this initiative to satisfy the requirements of ASTM's diverse stakeholder community and to meet the needs of industries relying on ASTM International standards."
Potential product benefits of the ASTM Product Certification Program to manufacturers and consumers include: increased confidence; reliable product comparisons; equitable testing and rating; potential liability reduction; and facilitating regulatory compliance, officials of the Conshohocken, Pa.-based organization state.
Requests for an ASTM program may come from ASTM technical committees or directly from industry, purchasers, or government bodies. A product certified through ASTM's program would be tested, at the direction of ASTM International, by a third-party laboratory to determine the product's ability to conform to one or more ASTM standards. All program initiatives will be based on the level of interest of the relevant ASTM technical committee as well as the support of industry.
Further information is available at the certification page of the ASTM Web site or by contacting Ken Pearson, senior vice president, at 610/832-9672 or firstname.lastname@example.com.


text:
Default Criteria has been set from Site defaults
The following average Sportsmanship scores by Level include any and all Match Reports filed by a Referee associated with a Match completed on or after 9/1/2016. This WILL include all local Teams, as well as teams that visit our area as Away or Visiting teams, and can include a report from both the center Referee AND up to two Assistant Referees.
You can review specific Level details (by Team) by clicking on the desired Level of play under "Key".
This summary is current as of Friday, June 23rd, 2017 at 6:37pm PDT and WILL change as additional Referee reports are received.


text:
I don't think so, but these are pretty good references for a decent number of makes and models
PocketGun Chart by BOB O
Compact Comparison Chart by David L
Is there, anywhere, a reference of trigger reach dimensions for various (hopefully all) pistols?
I don't think so, but these are pretty good references for a decent number of makes and models
PocketGun Chart by BOB O
Compact Comparison Chart by David L
After 12 days, it is obvious that the information does not exist. I have searched manufacturers websites and have come up with nothing.
So, apparently I will have to go to a store and take the measurements with a dial caliper.
My XDM9 measures 2.68" from the deepest point on the trigger (with the trigger safety depressed) to the throat of the grip (with the grip safety depressed).
My reason for this is to have a reference to my wife's comments about gun fit when trying various pistols for her first handgun.
I never found anything useful when I was trying to find the 'perfect' compact 9mm. I loved the Kahrs, but the trigger reach is so much too short for me that I have trouble shooting them. The G-26 is closer, but still not quite enough for me.
The CZ RAMI was perfect, as was the XD45 Compact, but being a double-stack with a wider grip has a lot of bearing on this, also.
I played with the comparison chart of pistol pictures by David L. as referenced in post #2. Although there is no trigger reach dimension noted, there is a reference of the dotted line square being a real 4 inches and the blue line along the trigger reach being 2.25 inches.
I zoomed the page until the square measured 4 inches. The blue line measured 2.25 inches. I then measured the trigger reach on the screen. This seemed to work but the accuracy may still be suspect.
Whereas the actual measurement on the gun of my XDM9 is 2.68, the screen measurement of the M&P9 appears to be 2.5 and the Kahr appears to be 2.4, although these are not full size pistols. The Kahr will feel smaller and have an effective shorter reach since it is single stack. A Kahr TP9093 might fit her. I intend to find out. She shot an SR9 for her training but complained that it was too big by her answer to this question, "did it feel like the gun was in your hand or your hand was on the gun"? My XDM also is too large for her even with the small backstrap.
I really hope we can find something other than a pocket gun because I am afraid that she will not practice with it .
Is there any chance there is a similar comparizon shart for full size pistols?
I've not seen a similar chart for full size guns, however some of those sizes will transfer over to their larger counterparts.
The Kahr line is a great choice, I have a friend that's missing the last bit of his index finger, we took a day and went to about three or four different shops just "trying on" guns and about the only reputable gun he good get good trigger finger placement on was the Kahr line, he went with a P9 and thus far has been pretty happy with it.
A Kel-Tec PF9 might also be a viable option.


text:
Cheap ISP & Low Cost ISP
Cheap ISP and Low Cost ISP is good option for home users and small businesses. Cheap ISP brings internet connection with cheap rate and reliable connection. Most of Cheap Dialup ISP has some limitations in dial up usage, customer support, email accounts, web space, etc.
With TheISPGuide.com you can find Cheap ISP and Low Cost ISP Providers in your area code, city or state with their plan, pricing, setup fee and hours. Search for your area code and get access to Cheap Internet Service Provider in your area.
Cheap Internet Service Provider
Copyright© 1999-2017 TheISPGuide.com All Rights Reserved.


text:
Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream
This study has been withdrawn prior to enrollment.
(Study withdrawn due to volunteer disinterest in participating.)
Johns Hopkins University
Information provided by (Responsible Party):
Anna Chien, Johns Hopkins University
ClinicalTrials.gov Identifier:
First received: May 5, 2011
Last updated: April 21, 2014
Last verified: April 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
Study was withdrawn before participants were enrolled.
|Study Status:
|This study has been withdrawn prior to enrollment.
|Study Completion Date:
|March 2014
|Primary Completion Date:
|March 2014 (Final data collection date for primary outcome measure)


text:
Harley White
Googleplexus - Poem by Harley White
Google me, google me, google me.
I'll google you, google you, google you.
Google me, too, oh do, please do.
Google me, too, boohoo.
Googling, googling whoop-de-do.
We're googling, googling, googling.
Googling all we see.
Googling you and me.
Hi, Instant Google, how do you do?
Google me through, wham bang, thank you.
You google me, and I'll google you.
IC, OIC, do you see me, too?
We google googolplex googols of Googlers.
We google googols and googols of Googles.
FYI, I've got a googlenym, too.
Google, I'm goo-google-eyed over you.
We're googling reams of memes and themes.
Some of us google googledom dreams.
Google gives cyberspace virtual shape.
We log-in our life on our google netscape.
But who's looking in as we're browsing about?
The question of privacy's always in doubt.
I'm googleplexed, Google, what are our web rights?
Are search engines searching us on our websites?
Now don't get me wrong, Google, you I adore.
I'm quite codependent on you to explore.
Your motto says, 'don't evil be', which is good.
I click on new features and feel understood.
For my part, I avoid social networking.
(I hate being nudged and 'not nows' are irking…
I'd rather tick, 'stop it', 'don't bug me', or 'halt'.)
My head's in your cloud, Google, you're my default.
You open the portal to info domains
And make user-friendly our surfing terrains.
Still, Google, this handiness could my mouse trick.
So many things seem so attractive to pick.
And lately I've found myself fraught with unease,
Afraid of those hyperlinks out there that tease.
Has 'googlephobe' entered the lexicon yet?
(Psst, I think Big Brother sneaks peeks at my net.)
Poet's Notes about The Poem
Comments about Googleplexus by Harley White
Harley White (9/8/2013 5:50:00 AM)
I now use Startpage, by the way, which calls itself the world's most private search engine. (Report) Reply
Misbahuddin Syed (6/9/2013 6:53:00 AM)
Read this poem in other languages
This poem has not been translated into any other language yet.
I would like to translate this poem »
Harley White's Other Poems
Famous Poems
Phenomenal Woman
Maya Angelou
Still I Rise
Maya Angelou
The Road Not Taken
Robert Frost
If You Forget Me
Pablo Neruda
Langston Hughes
Annabel Lee
Edgar Allan Poe
Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


text:
Spring is here so we're adding a bunch of new Summer dresses. This one is an adorable vintage dress from the 1950's. Made of pink crisp cotton with bold metallic silver designs all over. It has a full pleated skirt, metal zipper in back, and is in a larger size for a nice change with some extra fabric to let out at both side seams. It's way too big for our mannequin in the photos. This was made in Hawaii so it's a vintage Hawaiian dress but it has a wonderfully unusual design to the print, not the typical floral print one sees.
Condition Details: Freshly hand washed in natural organic soap. No holes or stains. Only minor general wear mostly only from washing, worn only 2 times ever.
Label: Tori Richard Honolulu
Size Details: each side seam has about 1/2" extra fabric to let out, It's way too big for our size 3 mannequin.
Bust: 36"/ 38" with darts
Waist: 26" aprox 1" total extra fabric at side seams to let out
Hips: Full
Total Length: Bodice 16" - Skirt is 32"- From top of shoulder to waist seam & bottom of fabric


text:
Extension > Source - Spring/Summer 2008
In this issue - Spring/Summer 2008
- From the Dean
- Finances got you stressed? Help is available
- 4-H's unique approach teaches essential life skills
- In the eye of the storm with Extension climatologist Mark Seeley
- Forging connections between Minnesotans and Mother Nature
- Healthy eating in a new land for Somali immigrants
- New faculty help invest in state's renewable energy future
- Armed and ready to defend Minnesota ash trees
- Fresh ideas for your garden online
- About Source
ON THE COVER: Charity, a 4-H participant in St. Cloud, paints a brighter future for a local park used by senior citizens with help from Casey Torgerson, 4-H Americorp Promise fellow. Research indicates that children who participate in 4-H are more likely to contribute to their communities than those involved in other youth development programs.
See past issues
View archives of past issues of Source


text: Back to basketball, and two local players, Messalonskee grad Megan Pelletier and Skowhegan's Levi Barnes, are making an instant impact at Thomas College. Both former high school standouts are in their rookie seasons, and they say it wasn't easy making the jump to the next level. Nick Coit has more.


text:
USA-Germany Report Card
Thomas Rongen's U-20s were below par in every facet of the game: poor touches, aimless passing, lax marking, you name it and it was a problem. Except for the first part of the second half, the Americans were never in the game.
It would been one thing if they were playing a top-level opponent, but Germany traveled to Egypt without many of its best players, retained by their Bundesliga clubs, and was further depleted by injuries and suspension.
Germany took the lead in the 30th minute when Brian Ownby was slow to track down Bjorn Kopplin and fouled the German in the penalty kick. Two minutes after German-based Semih Aydilek put the Germans ahead from the penalty spot, a corner kick sailed over a sea of U.S. defenders to an unmarked Florian Jungwirth, who made it 2-0 with a shot that goalie Brian Perk could only parry into his own goal.
The Americans' best chances came in the 62nd minute when Norwegian-American Mikkel Diskerud was put through by second-half sub Bryan Arguez but stopped by goalie Ron-Robert Zieler and in the 66th minute when Jared Jeffrey hit the crossbar from 25 yards out.
Any ideas of a comeback were quashed six minutes later when Cihan Kaptan, Germany's other Turkish-based player, was given acres of space on the right wing and fed Manuel Schaeffler breaking down the middle to put away the third goal.
"This clearly wasn't a good day for us," said Rongen, who anticipated that changes will be made for Tuesday's game against Cameroon (TV: ESPN2, live, 12:40 pm ET; Galavision, delay, 5 pm ET/PT).
Sept. 26 in Suez
USA 0 Germany 3. Goals: Aydilek pen. 30, Jungwirth 32, Schaffler 72.
USA -- Perk, Mayen, Agbossoumonde, Opara, Davies (Flores, 36), Powers (Arguez, 46), Jeffrey, Diskerud (Duka, 78), Ownby, Shea, Taylor.
Germany -- Zieler, Jung, Jungwirth, Lars Bender, Vrancic, Sukuta-Pasu, Holtby (Kaptan, 71), Kopplin, Aydilek (Vrzogic, 81), Funk, Kempe (Schaeffler, 64).
Yellow Cards: USA -- Ownby 29; Germany -- Jungwirth 63.
Referee: Yuichi Nishimura (JPN)