text:
|Numķro de publication
|Type de publication
|Numķro de demande
|Date de publication
|14 nov. 2006
|Date de dķp¶t
|14 sept. 2001
|Date de prioritķ
|14 sept. 2001
|╔tat de paiement des frais
|Autre rķfķrence de publication
|Numķro de publication
|Margo Gisselberg, Eric Hadford, Steven C. Dimmer, Jack Goldberg, Jeff Pelton, Kurt Zublin
|Cessionnaire d'origine
|Calypso Medical Technologies, Inc.
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Citations de brevets (120), Citations hors brevets (7), Rķfķrencķ par (79), Classifications (23), ╔vķnements juridiques (5)
|Liens externes: USPTO, Cession USPTO, Espacenet
This invention relates to locating devices, and more particularly to miniature resonating marker assemblies and methods of tuning the same.
Medical procedures often require locating and treating areas within a patient's body. Imaging systems, including x-ray, MRI, CT, and ultrasound have been used to help locate areas or particular targets within the body. While the imaging systems can be very useful in some situations, they can be limited to two dimensional information and may be unusable or difficult to use in certain procedures to provide real time three dimensional location information about a target.
Many noninvasive medical procedures, such as radiation therapy and surgical procedures, require precise location information about the target to minimize the extent of collateral damage to healthy tissue around the target. Markers have been used to locate targets on and in a patient's body in preparation for a medical procedure. One example includes the use of gold fiducials, which are solid, inert, metal beads that can be implanted in a patient at or near a tumor or other target that may be difficult to accurately detect using conventional imaging systems. The fiducial markers are passive markers that are easy to detect with imaging systems such as x-ray or ultrasound systems, but the passive markers do not provide active real-time location information during a medical procedure.
Active, implantable marker assemblies that generate a detectable signal have been used to locate a selected target or the like in real time. Many of the active markers are implantable in a patient, but they are hard-wired to a power source or other equipment external from the patient. These hard-wired markers are removed from the patient's body after a procedure or a series of procedures are concluded. The hard-wired markers are often fairly large in order to provide desired signal strength, clarity, or other performance characteristics needed during the procedure. The patient's body can typically temporarily handle the larger marker during the medical procedure before the marker must be removed. The removal process, however, requires an additional invasive procedure to the patient's body.
Leadless active markers also referred to as "wireless" active markers, have been developed to be implanted in a patient's body at or near a selected target, such as a tumor. The wireless active markers are typically activated or energized to generate a detectable signal used to locate the marker in the patient's body. Some wireless markers contain a power source, such as a battery, that provides the power to generate a signal detectable from outside the patient's body. The battery-powered markers, however, typically must be removed after the medical procedure because the caustic materials in the battery are not suitable to leave in a patient.
The conventional, wireless active markers are also often fairly large in order to provide a range of operating characteristics that allow the marker to be accurately located within the patient's body. Wireless active markers have experienced a trade-off between physical size and signal strength. Larger active markers have been needed to provide the required signal strength for detection and must be tuned adequately enough so that the detection system can detect the marker's signal. The large active markers, however, have drawbacks, including a reduced accuracy of determining the marker's precise location relative to a target, the degree of invasiveness needed to implant the markers in the body, and the costs of producing accurately tuned markers.
Under one aspect of the invention, a miniature resonating marker assembly is provided that overcomes drawbacks experienced in the prior art. In one embodiment, the resonating marker assembly includes a core, a wire coil composed of insulated wire disposed around the core, and a capacitor connected to the wire coil adjacent to the core. The core, coil, and capacitor form a signal element that, when energized, generates a magnetic field at the predetermined resonant frequency. The magnetic field has a magnetic center point positioned along at least one axis of the signal element. An inert encapsulation member encapsulates the signal element therein and defines a geometric shape of the resonating marker assembly. The geometric shape has a geometric center point substantially coincident with the magnetic center point along at least a first axis of the signal element. Accordingly, when a user locates the marker assembly's magnetic center point, the user will have also located the marker assembly's geometric center point. Conversely, when a user locates the marker assembly's geometric center, the user will have also located the marker assembly's magnetic center point.
In another embodiment, the miniature resonating marker assembly has a ferromagnetic core with an elongated central portion and two enlarged end portions attached to or integrally connected to the central portion. A first end portion has an axial thickness different from the thickness of the second end portion to define a core asymmetric about at least one axis through the marker assembly. A wire coil is disposed around the central portion of the core between the first and second enlarged end portions. A capacitor is connected to the coil adjacent to the core to form a signal element tuned to a selected resonant frequency. The magnetic center point of the signal element is substantially coincident with the geometric center point of the resonating marker assembly.
In another embodiment, the miniature resonating marker assembly has a core made of a material having a relative permeability greater than 1. The core has an elongated central portion and two endcaps connected to the central portion. One or more of the endcaps is axially movable relative to the central portion. A wire coil is disposed around the central portion of the core between the first and second endcaps. A capacitor, positioned adjacent to the core, is connected to the wire coil. Test equipment is attached and the resonant frequency is measured. The first endcap is movable relative to the coil and the core's central portion and is used to tune the circuit. Once the movable endcap is positioned at the desired location, the endcap is secured in place, the test equipment is removed from the circuit, and the signal element is completed by attaching the inductor lead to the capacitor terminal.
In another embodiment, the miniature resonating marker assembly has an elongated plastic sleeve with a wire coil disposed on the sleeve. A central portion of a core is placed within the sleeve, and a pair of endcaps are connected to the sleeve so that the coil is positioned between the endcaps. A capacitor is operatively connected to the wire coil and positioned adjacent to the core to form a signal element. The central portion of the core is axially movable relative to the sleeve and the coil and is used for tuning the marker assembly to a selected resonant frequency prior to completing the marker assembly.
In another embodiment, the miniature resonating marker assembly has a core with an end portion having a recess formed therein. A capacitor is positioned in the recess, and a wire coil is disposed around the core adjacent to the end portion and is operatively connected to the capacitor to form a signal element tuned to resonate at a selected frequency.
In another embodiment, the miniature resonating marker assembly has a core with a central portion and a pair of enlarged endcaps connected to the central portion. The central portion is made of a first material with a first magnetic permeability, and the endcaps are made of at least a second material with a second magnetic permeability different than the first magnetic permeability. A wire coil is disposed around the core between the endcaps, and a capacitor is operatively connected to the coil to form a tuned signal element.
In another embodiment, the resonating marker assembly has an annular-shaped capacitor with a central aperture, and an elongated ferromagnetic core extends through the aperture in the capacitor. A wire coil is disposed about the core and is connected to the capacitor. The wire coil has first and second portions. The first portion is disposed around the core on one side of the capacitor, and the second portion is disposed around the core on the other side of the capacitor.
In another embodiment, a method is provided for actively tuning the resonating signal element of a miniature marker during the manufacturing process. The method includes wrapping a first number of windings of an elongated wire around a central portion of a ferromagnetic core between a pair of endcaps to form a wire coil with the first number of windings. The coil with the first number of windings and the core form an inductor with a first inductance value. The first inductance value is actively measured and compared with a target inductance value. The number of windings forming the coil is then adjusted by adding or removing one or more windings from the core to form a coil with a second number of windings to form an inductor with a second inductance value substantially equal to the target inductance value.
In another embodiment, a method is provided for tuning a miniature resonating marker assembly to have a target resonant frequency by placing a core within a wire coil that has a plurality of windings. The core is made of a material with a relative permeability greater than 1. Lead lines of the wire coil are connected to a capacitor adjacent to the core to form a resonating marker unit. Test equipment is attached for measuring the resonant frequency. A first resonant frequency value of the resonating marker unit is measured and compared to the target resonant frequency value. The core is moved axially relative to the wire coil to adjust the resonant frequency value of the resonating marker unit to a second resonant frequency value substantially equal to the target resonant frequency value. The core is secured in a fixed location relative to the coil and the capacitor after the target resonant frequency value is reached. After retesting to confirm that the desired resonant frequency has been achieved, the test equipment is removed.(Lead lines have already been connected as stated above.) Once the circuit has been completed, neither the inductance nor the capacitance of the individual components can be directly measured. However, the impedance and phase angle of the tuned circuit can be measured which allows the resonant frequency and the quality factor (Q factor) of the tuned circuit to be determined.
In the following description, certain specific details are set forth in order to provide a thorough understanding of various embodiments of the invention. However, one skilled in the art will understand that the invention may be practiced without these details. In other instances, well-known structures associated with resonating markers and activators have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the invention.
The marker assembly 10 includes a coil 12 wound around a ferromagnetic core 14 to form an inductor. The inductor is connected to a capacitor 16, so as to form a signal element 18. Accordingly, the signal element 18 is an inductor (L) capacitor (C) series circuit. The signal element 18 is enclosed and sealed in an encapsulation member 20 made of plastic, glass, or other inert material. Accordingly, the marker assembly 10 is a fully contained and inert unit that can be used, as an example, in medical procedures in which the marker assembly is secured on and/or implanted in a patient's body.
The marker assembly 10 can be activated by an external excitation source(s) 22, so the signal element 18 generates a detectable signal that allows the marker assembly to be precisely located, for example, during a medical procedure. The excitation source 22, in one embodiment, generates a magnetic field 24 at a selected frequency that substantially matches the resonant frequency of the specifically tuned marker assembly 10. When the marker assembly 10 is excited by the magnetic field 24, the signal element 18 generates a response signal at the resonant frequency 90 degrees out of phase with the magnetic field. The marker assembly 10 is constructed, as discussed in detail below, to provide an appropriately "loud" and distinct signal by optimizing marker characteristics, such as the quality factor, for example, and by providing an accurate and precise means of tuning the marker to a predetermined frequency to allow reliable detection by the marker detection system 11. The signal from the accurately tuned marker assembly 10 is sufficient to allow the marker detection system 11 to determine the marker assembly's identity, precise location, and orientation in three dimensional space.
The miniature marker assemblies 10 discussed below are accurately tuned to a chosen resonant frequency. Because the miniature marker assemblies 10 are constructed to be very small, the markers must be tuned so that, when energized, they will provide a response signal that is strong and clearly distinguishable from the excitation signal, signals from other markers, and environmental noise. Accordingly, the signal will have a strength, clarity, and uniqueness that can be detected and analyzed by the sensor system 26 to determine the precise location of the marker assemblies 10 on and/or within the patient relative to the sensor system. The information regarding the precise location and orientation of the marker assemblies 10 and the target areas is then usable to help minimize collateral damage to healthy tissues around the targets during radiation therapy, surgical procedures, or other selected medical procedures that require locating and tracking a specific tissue or area for monitoring or treatment purposes.
In the illustrated embodiment, the core 14 is a material having a relative permeability greater than 1, such as a ferromagnetic material. In one embodiment, the core 14 is made from a selected ferromagnetic material, such as Fair Rite 78. The core 14 includes an elongated central portion 28 and a pair of enlarged ferromagnetic endcaps 32 attached to the ends of the central portion 28. The endcaps 32 in the illustrated embodiment are ferromagnetic endcaps. The wire coil 12 is wound around the central portion 28 between the endcaps 32. In the illustrated embodiment, the endcaps 32 are substantially cylindrical and each has an outer diameter approximately the same as the outer diameter of the coil 12.
The wire coil 12 in the illustrated embodiment is made up of approximately 100–3,000 windings 30 of a low resistance, small diameter, insulated wire (e.g., 45–54 AWG, American Wire Gauge) tightly wound around the core's central portion 28. The number of windings 30 in the coil 12 depends upon the wire type, the wire size, the wire shape, the number of wires, the wind geometry, the core size, the core's material, the core's geometry, and the inductance required to tune the signal element 18. As shown in
Alternatively, especially at higher frequencies, it may be desirable to increase the distance between the coiled wires in a way that does not result in random winding. One way to increase the distance in a predictable and repeatable manner is to use insulated wire having a thicker insulation coating around the wire filament. Accordingly, the wire filaments in adjacent winds are spaced further apart, even though the insulated wire is wound in the tightly packed configuration shown in
Another way to increase the distance between adjacent winds in an organized but less tightly packed configuration is to place each wind on top of adjacent windings rather than in the valley area 31. In this configuration the coil is wound such that each wire is adjacent to only four of its nearest neighbors.
As best seen in
The signal element 18 in the marker assembly 10 also generates a magnetic field when the signal element is excited, and the magnetic field has a magnetic center point 36. If the core 14 was a symmetrical member about the X, Y, and Z axis, the endcaps 32 would be the same size, and the magnetic center point 36 would be offset from the marker assembly's geometric center point 34. The core 14 of the illustrated embodiment, however, is an asymmetric core with endcaps 32 having different thicknesses. The core 14 is shaped and sized so that the magnetic center 36 of the signal element 18 is coincident with the geometric center 34 of the marker assembly 10.
The asymmetric configuration of the core 14 effectively shifts the center of the magnetic field axially along the length of the core. The signal element 18 can be configured and positioned in the encapsulation member 20 so that the geometric and magnetic centers 34 and 36 are coincident with each other. The coincident orientation of the geometric and magnetic centers 34 and 36 allows a physician or technician to nonvisually determine the precise location of an implanted marker assembly 10 relative to a target during a medical procedure.
As an example, the marker assembly 10 can be implanted either permanently or short-term in a patient and located visually with an imaging system to determine the marker assembly's position and location relative to the target before initiating a selected medical procedure. The physician or technician can visually determine the marker assembly's geometric center 34 relative to the target. The information about the geometric center 34 relative to the target can be utilized to provide patient set-up procedures or a treatment plan. The physician or technician will know that, when the marker assembly 10 is excited via the excitation source(s) 22 (
The asymmetric core 14 illustrated in
For marker assemblies that will be implanted, it is highly desirable to minimize the size of the marker assembly 10 to allow for accurate and minimally invasive placement of the assembly into body tissues and cavities via such methods as introducer needles, endoscopes, catheters, etc. There are trade-offs, however, between marker size and signal strength, because smaller markers typically provide weaker signals. Therefore, the miniature marker assembly 10 should be as small as possible while still providing an adequate response signal over environmental noise when energized by the excitation source(s) 22. To maximize the signal strength of the marker assembly 10, the outer diameter of the coil 12 and ferromagnetic core 14 should be maximized relative to the outer dimension of the marker assembly. The marker assembly 10 of the illustrated embodiment accomplishes this, in part, because the capacitor 16 and any other components, such as a tissue fastener 29 (illustrated in phantom lines connected to the marker assembly), are axially aligned with the core 14 and positioned at the proximal or distal ends of the core. The size constraints for markers placed on the body are less stringent than for implanted markers.
In the illustrated embodiment of
During the manufacturing process of the marker assembly 10, the endcap 32 is axially adjusted to precisely tune the marker assembly. In one embodiment, the entire signal element 18 is assembled with the exception of the movable endcap 32. The movable endcap 32 is then slipped onto the end of the core's central portion 28 and positioned axially toward the coil 12 to achieve the required inductance to obtain the desired resonant frequency.
The axial position of the ferromagnetic endcap 32 can be determined by axially moving the endcap 32 and simultaneously measuring the impedance phase shift at the frequency of interest with an impedance analyzer. The impedance analyzer is connected to the coil's lead wires that connect to the capacitor 16. When the impedance analyzer determines that the phase shift is equal to zero, the capacitor impedance and the inductor impedance are matched for the selected frequency. The endcap 32 is then secured in place on the core's central portion 28 with an adhesive, such as a UV-cured or heat-cured epoxy.
The above process of tuning the miniature marker assembly 10 allows for extremely accurate tuning during mass production of the marker assemblies while minimizing the degree of variation between two marker assemblies tuned to the same frequency. The signal elements 18 of marker assemblies 10 having a tuning accuracy in the range of ▒0.5% of the desired resonant frequency can be economically manufactured in large quantities. In one embodiment, signal elements 18 can be economically tuned consistently during manufacturing with a margin of error as low as ▒0.2% of the desired resonant frequency.
In another embodiment, the resonant frequency of the signal element 18 can be finely tuned by removing material from the ferromagnetic core 14 by, as an example, laser cutting or machining ferromagnetic material from an endcap 32 or the core's central portion 28. In another embodiment, fine tuning of the signal element 18 can be accomplished by removing material from the capacitor 16. The resonant frequency of the signal element 18 can be actively or dynamically measured during the material removal process to determine when the phase shift is zero and inductive reactance equals the capacitive reactance of the signal element.
After the endcap 32 is fixed in position on the core's central portion 28, the tuned signal element 18 can be carefully slid into the encapsulation member 20 (
In the illustrated embodiment, a preformed plastic sleeve 40 is used in the coil winding process so the coil 12 is wound directly onto the sleeve in the tight winding configuration as discussed above. The ferromagnetic endcaps 42 can be adhered to the plastic sleeve 40 either before or after the winding process. After the coil 12 and the ferromagnetic endcaps 42 are securely positioned on the plastic sleeve 40, the ferromagnetic rod 44 is inserted into the plastic sleeve and axially positioned relative to the coil 12 until the target resonant frequency of the signal element 18 is achieved. In one embodiment, the resonant frequency is measured dynamically as the ferromagnetic rod 44 is adjusted axially relative to the coil 12 until the inductive reactance matches the capacitive reactance. This dynamic measuring of the resonant frequency allows the ferromagnetic rod 44 to be precisely positioned during tuning of the marker assembly 10. Accordingly, the marker assembly 10 provides the maximum tunability to a desired inductance for a given frequency.
As best seen in
Once the ferromagnetic rod 44 is positioned in the plastic sleeve 40 to achieve the specific inductance, thereby tuning the signal element 18 to resonate at a selected frequency, the ferromagnetic rod is securely affixed in position with an adhesive. In one embodiment, the adhesive is a UV-cured epoxy, a polyurethane adhesive, or a ferromagnetic-based adhesive. In the case of the ferromagnetic-based adhesive, the uncured adhesive should be present in the bond line joint during tuning so that the resonant frequency does not shift. The tuned signal element 18 is then encapsulated in the inert encapsulation member 20 (
In a simpler alternate configuration, ferromagnetic endcaps are not incorporated in the signal element 18 and the ferromagnetic core 14 may be just the ferromagnetic rod 44 having a length the same as the coil 12, shorter than the coil, or longer than the coil. The signal element 18 is then tuned by moving the ferromagnetic rod 44 within the coil 12, which may or may not be wound on a plastic sleeve. Ferromagnetic paste or adhesive may also be used in place of preformed rigid ferromagnetic cores. In this configuration, the signal element is tuned to a specific resonant frequency by injecting ferromagnetic paste into the center of the coil.
The encapsulation member 20 can be a plastic or glass sleeve sealed on both ends so as to fully enclose the tuned signal element 18. For marker assemblies 10 designed for use in medical procedures in which the marker assemblies may be permanently implanted in a patient, the signal elements 18 are encapsulated in part to protect the patient's tissues from exposure to any non-biocompatible materials that may be used to optimize the marker signals. The encapsulation member 20 also insulates the signal element 18 from bodily fluids that may cause corrosion or oxidation of the signal element and affect its performance. The encapsulation member 20 hermetically seals the signal element 18 without adversely affecting the signal element or its emitted signal.
In one embodiment the signal element is encapsulated in a strong, rigid, and biocompatible material such as epoxy that helps protect the signal element 18 from mechanical damage.
Alternatively, the signal element 18 can be placed inside of a biocompatible encapsulation sleeve 49 as shown in
Some benefits of using an encapsulation sleeve 49 are that the sleeve can be used to help center the signal element 18, help to prevent damage to the signal element during handling, and help make the encapsulation process easier by preventing the signal element from being exposed during encapsulation. For example, if the signal element 18 was not placed in an encapsulation sleeve 49 prior to potting with epoxy, the signal element may move to the side of the mold and be exposed after the epoxy had cured. To prevent this phenomena from occurring, the signal element 18 needs to be placed in a sleeve 49 or otherwise coated before completing the final encapsulation process.
In another embodiment, the encapsulation member 20 is composed of sturdy, durable, biocompatible heat-shrink tubing. The signal element 18 is placed in the heat-shrink material, and heat is applied until the material shrinks and encases the signal element. The heat-shrink material is selected so that the heat necessary to shrink the material is not high enough to damage the signal element 18. In an additional embodiment, the signal element 18 and the shrunken encapsulating sleeve are potted in epoxy to fully enclose and seal the signal element 18.
The signal element 18 in other embodiments can be encapsulated with one or more materials. Using multiple materials can make the encapsulation process easier and can allow additional functionality to be incorporated into the marker assembly 10. As an example, the signal element 18 can be encapsulated with a rigid biocompatible material, such as an epoxy, to protect the components from damage. The epoxy also would provide a rigid base for, as an example, attaching a fastener for mechanically attaching the marker assembly to tissue in the patient, thereby preventing the marker assembly from migrating immediately following marker deployment in the patient and during the implant duration.
An additional biocompatible coating material may be placed on the outside of the rigid encapsulation member 20 to react with the tissue and help the marker assembly 10 adhere to the tissue. The additional coating material can also help promote or accelerate tissue encapsulation of the marker. Eliciting a specific biological response at the marker/tissue interface could also be beneficial in preventing marker assembly migration, especially in soft tissue.
In another embodiment, the encapsulation member 20 includes a biocompatible, thin-walled glass or plastic vial. These vials are similar to the previously described encapsulation sleeves 49 except one end is already sealed prior to insertion of the signal element 18. The signal element 18 is placed into the vial and an encapsulation material, such as a quick-curing adhesive or epoxy, is injected into the vial to fully encase the signal element. After the signal element 18 is placed in the vial, the epoxy or other material is dispensed into the vial so as to avoid entrapping air bubbles in the vial. Avoiding air bubbles is important because if the vial is damaged at the site of a large bubble, part of the signal element may be exposed to body fluids and tissues. When the signal element 18 is placed in the previously discussed glass or plastic small-bore sleeve, epoxy can be injected into the sleeve to more easily avoid the formation of air bubbles within the sleeve.
Using glass can be advantageous because glass is inert and insoluble. The characteristics of glass are also very desirable for long-term implantation of marker assemblies. If undamaged, the glass will prevent leakage (egress) of incompatible materials from the signal element 18 and ingress of tissue fluids to the signal element. In another embodiment, powdered or granular glass is combined with biocompatible epoxy and used to encapsulate the signal elements 18 placed in sleeves or vials. In another embodiment the signal element 18 can be secured with an adhesive inside an encapsulation sleeve or vial and the end(s) of the sleeve/vial can be closed using heat or a laser to melt and seal the end(s) of the vial or sleeve.
Tuning of the marker assembly's 10 signal element 18 is achieved by axially moving one or both of the core pieces 48 relative to each other and to the coil 12. The resonant frequency can be actively measured during the axial movement of one or both of the core pieces 48 until the inductive reactance of the signal element 18 and the capacitive reactance are matched for the selected frequency. After the marker assembly's signal element 18 has been accurately tuned to resonate at the selected frequency, the core pieces 48 are fixed in position relative to the plastic sleeve 40 and the coil 12 by an adhesive. The signal element 18 can be inserted into an encapsulation member and hermetically sealed to provide the fully enclosed and inert miniature marker assembly 10 suitable for implantation in a patient.
In the illustrated embodiment, a coil winding machine is used to wind the coil 12 onto a metal mandrel and then eject the coil off the mandrel. Winding the coil 12 onto a metal mandrel has benefits over winding directly onto the small diameter (e.g., 0.75 mm) ferromagnetic rod 44 because the ferromagnetic rod must be supported on both ends to prevent fracture and/or breakage. Securely holding the ferromagnetic rod 44 with a spindle and tail stock of the winding machine requires concentricity of the small components, because slight misalignment can also lead to fracture and/or breakage of the ferromagnetic rod. Winding the coil 12 onto a metal mandrel of a coil winding device rather than directly onto the ferromagnetic core 44 is more conducive to a fully automated process because the small ferromagnetic core does not have to be preloaded prior to starting the winding process.
The core 14 is positioned so the ferromagnetic rod 44 extends through an interior area 50 in the coil 12. The coil's interior area 50 is sized to provide a clearance fit with the ferromagnetic rod 44, so there is a slight space between the ferromagnetic rod and the inner wall of the coil 12. A ferromagnetic-based adhesive 52 can be used at the interface between the ferromagnetic rod 44 and the coil 12 during assembly to eliminate the air gap between the components, to provide additional ferromagnetic material within the coil, and to secure the ferromagnetic rod 44 to the coil 12. Adding additional ferromagnetic increases the inductance of the signal element 18 without increasing the signal element's size. The endcaps 32 are attached to the ends of the ferromagnetic rod 44 with the coil 12 between them.
The signal element 18 can be tuned to the selected resonant frequency by axially adjusting the ferromagnetic rod 44 and/or an endcap 32 relative to the coil 12. Once the signal element 18 is precisely tuned, the adhesive 52 is allowed to set or cure, and the ferromagnetic rod 44 is fixed in position in the coil 12 and the endcap 32 is fixed in position on the ferromagnetic rod. The tuned signal element 18 can then be positioned in an encapsulating member 20 (
The recess 68 in the endcap 66 can be formed by grinding, molding, or laser cutting the endcap. The recess 68 is designed to position the capacitor 16 in a selected orientation relative to the coil 12 such that, when the coil is installed or wound onto the ferromagnetic rod 64, a minimum length of lead wire 75 is needed to connect the coil to the capacitor. This orientation of the recess 68 and the capacitor 16 also provides a compact tunable configuration that increases commonality of the miniature marker assembly 10, which makes mass production of tuned marker assemblies 10 more efficient and economical.
In one embodiment, a spacer or coating is provided within the recess 68 between the endcap 66 and the capacitor 16. The spacer or coating can help avoid electrical shorts with the capacitor 16 and can provide a surface with different bonding characteristics to hold the capacitor in place.
The small physical size and fragility of the signal element 18 are such that complete assembly of the tuned signal element can be difficult. The small capacitors 16, especially the standard 0603, 0504, and 0402 size capacitors, can be dramatically affected during the process of soldering the lead wires 75 to the terminals 73. These small capacitors 16 have such high ratios of contact surface area to total volume that they can inadvertently adhere to a soldering tip during the assembly process, which can result in a failed joint or a damaged capacitor.
Mounting the capacitor 16 in the recess 68 helps alleviate the manufacturing difficulties, because the endcap 66 holds the capacitor in place with the proper, known, and consistent orientation with respect to the coil 12 and lead wires 75. When the capacitor 16 is centered in the recess 68, the capacitor is captured between the side portions of the endcap 66. The side portions work with the adhesive to provide a protective structural support for the capacitor 16. With this method, a simple axial load can be applied to retain the capacitor 16 within the recess 68 during application and curing of an adhesive. Once the capacitor 16 is structurally secured in the recessed endcap 66, the coil lead wires 75 may be readily soldered to the capacitor terminals 73.
As seen in
In an alternate configuration, the connections between the coil 12 and the capacitor 16 are covered or sealed with an adhesive or epoxy prior to the encapsulation process. Sealing the connections helps prevent damage during the encapsulation process and helps prevent corrosion of the signal element in cases where the marker encapsulation is damaged during or prior to implantation. The connection between the coil 12 and capacitor 16 is an area of the signal element where the small diameter wire is not protected by a coating of insulation.
As best seen in
The annular-shaped capacitor 86 in this alternate embodiment has a similar disk shape and outer diameter as that of the endcaps 90. A central aperture 92 extends through the capacitor 86, and the ferromagnetic rod 88 extends through the capacitor's central aperture. Accordingly, the capacitor 86 is positioned generally in the middle of the signal element 80 between the endcaps 90.
The coil 84 is wound in two segments onto the ferromagnetic rod 88 between the endcaps 90 and the capacitor 86. Accordingly, one coil segment 93 is wound around the ferromagnetic rod 88 between one endcap 90 and the capacitor 86, and a second coil segment 95 is wound around the ferromagnetic rod between the other endcap and the other side of the capacitor. In one embodiment, the two coil segments 93 and 95 are formed by one continuous wire. In an alternate embodiment, the coil segments 93 and 95 may be formed by separate wires interconnected to provide the electrical continuity of the coil 84.
The signal element 80 of this marker assembly 10 is tuned in one embodiment by axially adjusting the position of one or both of the endcaps 90 relative to the ferromagnetic rod 88 and the coil 84 until the signal element is tuned to resonate at the selected frequency. Once the signal element 80 is tuned and the endcaps 90 are secured in position on the ferromagnetic rod 88, the signal element can be encapsulated to provide the inert resonating marker assembly 10.
The marker assembly 96 also includes an elongated coil 106 tightly wound around the web 102 between the flanges 104. The I-beam configuration of the core 100 allows each winding of the elongated coil 106 to cover more of the core 100 than the previously described marker configurations, thereby allowing for more inductance with less wire. In one embodiment, the web 102 has a shorter axial length than the flanges 104, such that the end portions of the web are recessed. The coil 106 is wound around the recessed web 102 so the coil does not extend beyond the ends of the flanges 104 to increase the length of the marker assembly 96. A capacitor 108 (
The modular endcaps 144 are made up of a plurality of annular-shaped ferromagnetic disks 148 each with a central aperture 149 that receives the end portion of the ferromagnetic rod 142. If an asymmetric core 136 is desired, the modular endcaps 144 can be easily constructed with a different number of ferromagnetic disks 148 or with disks of different thicknesses, so as to achieve the selected ultimate volume of ferromagnetic material at each end of the ferromagnetic rod 142. Accordingly, the characteristics of the signal element 132 can be selected and/or modified by combining a different number or type of ferromagnetic disks 148 to form the modular endcaps 144.
When a large number of miniature marker assemblies 130 are to be manufactured, the same modular components of the ferromagnetic core 136 can be used in different combinations to achieve the tuned marker assembly. Once the modular endcaps 144 are in place on the ferromagnetic rod 142, the ferromagnetic disks 148 can be adjusted axially relative to the ferromagnetic rod and the coil 138 to actively tune the marker assembly 130 to resonate at the selected frequency. Alternatively, the ferromagnetic rod 142 may be axially moved relative to the coil 132 and the modular endcaps 144 to achieve the necessary inductance to tune the signal element 132. After the signal element 132 is accurately tuned, the modular endcaps 144 and central ferromagnetic rod 142 are fixed in position so the signal element remains accurately tuned. The signal element 132 can then be inserted into the encapsulation member 134 and hermetically sealed.
In an alternate embodiment, the characteristics of the signal element 132 may be controlled by combining a central rod 142 made of one ferromagnetic material, and enlarged endcaps 144 made of another ferromagnetic material. The ferromagnetic material for the rod 142 has a first magnetic permeability and saturates at a high field strength, and the ferromagnetic material for the endcaps 144 has a greater magnetic permeability and saturates at a lower field strength. Accordingly, the ferromagnetic core 136 can have a substantially uniform saturation characteristic throughout the core, thereby minimizing the effects of saturation on the resonating marker assembly 130. As an example, in one embodiment, the endcaps 144 may be made of Fair Rite 78 and the ferromagnetic rod 142 may be manufactured of a power ferromagnetic having less magnetic permeability and a higher saturation level. The ferromagnetic rod 142 made of the power ferromagnetic material allows more windings around the rod to form the coil 138 without saturation of the central ferromagnetic rod.
The windings and the core 136 including endcaps 144 of the signal element 132 makeup the elements of the signal element's inductor. For a first order approximation, the inductance of the signal element 132 is optimized for a given volume when the number of turns is maximized, the enclosed area for each turn is maximized, the length of the coil is minimized, the initial permeability of the core is maximized, and the length/diameter ratio of the core is maximized. Also, for a first order approximation, the quality factor (Q factor) of the signal element 132 is optimized when the inductance is maximized and the resistance of the windings and core 136 is minimized. Typically, the resistance of the windings and core 136 will be nearly equal at the chosen frequency when the inductor has been optimized. Other items that must be addressed when optimizing the Q factor include multiple layer windings, the presence of endcaps 144, and frequency dependent losses including dielectric loss and ferrite loss. Accordingly, the marker assembly 130 is designed to provide a maximum Q factor for the marker assembly at a chosen frequency. The embodiment utilizing endcaps 144 with a material having a different permeability than the ferromagnetic rod 142 can be either modular endcaps as shown in
The process of manufacturing the miniature marker assembly 10 in one embodiment involves actively measuring the marker assembly's inductance during the coil winding process. The process is discussed with reference to
In one embodiment of the manufacturing method, a core 160 with a capacitor 162 affixed thereto is installed in a coil winding machine 166. After the core 160 is positioned in the winding machine 166, a test probe advances forward and makes contact with the capacitor 162 at one test point, such as the capacitor terminal 168. A second test probe is advanced forward to make contact with the other capacitor contact. The capacitor's capacitance is measured and the test probes are retracted. From the capacitance, an empirically derived formula based on the chosen wire size and the core material and other critical inductor parameters are used to identify the inductance value necessary to obtain the desired resonant frequency for the LC series circuit being produced. A single, long strand of wire 164 is connected at one end to the capacitor terminal 168 on the capacitor 162. The coil winding machine 166 is activated to spin the core 160 and capacitor 162 as a unit so as to tightly wind the wire 164 onto the central rod 150 of the ferromagnetic core between the endcaps 152. The windings are controlled to be immediately adjacent to each other so as to minimize the amount of space between windings, as discussed above and shown in
The individual characteristics of the capacitor 162, the ferromagnetic core 160, and the wire 164 are generally known, so the approximate number of windings needed in the coil 154 can be calculated to approximately achieve the desired inductance needed to tune the signal element. The coil winding machine 166 is used to wind the coil 154 with the initially calculated number of windings. In one embodiment, the coil 154 is wound about the core 160 with a selected number of turns calculated with the empirically derived formula to achieve an inductance value slightly less than necessary to obtain the desired LC series circuit resonant frequency.
After the calculated number of windings are wound onto the core 160, a test probe advances forward making contact with one of the capacitor terminals 168 to which the wire is connected, and another test probe is advanced to make contact with the other end of the wire 164 at the wire takeoff spool (not shown) on the coil winding machine 166. The inductance is dynamically measured and compared to the actual inductance required to obtain the desired resonant frequency of the LC series circuit. The difference between the actual inductance and the target inductance is used to calculate the additional number of windings necessary to add to the coil 154 to accurately achieve the target inductance within a very small margin of error during the manufacturing process. The calculated number of additional windings are added to the coil 154 to achieve the target inductance.
In one embodiment, the actual inductance is measured again after the additional windings are added to the coil 154 to confirm that the actual inductance matches the target inductance within a selected margin of error, as an example, in the range of approximately ▒0.2% of the target inductance. The dynamic inductance measurement process can be iteratively used as many times as needed to achieve the inductance needed to obtain the fine-tuned LC series circuit. In one embodiment, if the measured inductance is within 0.5% of the required tuned circuit inductance, the additional windings are added one at a time, with a dynamic inductance measurement taken after each winding is added until the measured inductance matches the required tuned circuit inductance within the resolution of the inductance measuring device.
In one embodiment wherein the coil 154 is wound onto a dumbbell-shaped ferromagnetic core 160, an initial manual process begins with a start turn termination. A small bead of adhesive (e.g., UV-spot-curing type or the like) is used to secure the end of the wire 164 to the ferromagnetic core 160 immediately adjacent to the winding area on the circumference of one of the endcaps 152. The adhesive also serves as a strain relief for the eventual termination to the capacitor terminal 168. The exposed length of wire 164 is twisted back on itself and tinned to provide one of the electrical connections for the dynamic inductance measurement. Following the winding of the first iteration of windings, a service loop is drawn from the wire spool from a location between the spool and the input to a tensioner device. The length of the service loop is determined by the empirically derived formula. As with the start turn termination, the end of the uncut service loop is twisted back on itself and tinned. This provides a second electrical connection for the dynamic inductance measurement.
In the illustrated embodiment, the method of dynamic tuning of the LC series circuit for the resonating marker assembly 10 is used for automated manufacturing of the miniature resonating marker assemblies tuned within a tolerance of approximately ▒0.5% of the target resonant frequency. Such highly accurate tuning of the resonating marker assembly 10 allows for extremely accurate manufacturing of relatively large volumes of the miniature resonating marker assemblies in a very efficient and cost-effective manner. In addition, large quantities of miniature resonating marker assemblies 10 having different resonating frequencies can be manufactured efficiently and cost effectively.
Although specific embodiments of, and examples for, the present invention are described herein for illustrative purposes, various equivalent modifications can be made without departing from the spirit and scope of the invention, as will be recognized by those skilled in the relevant art. The teachings provided herein of the present invention can be applied to resonating marker assemblies, not necessarily the exemplary implantable resonating marker assemblies generally described above.
These and other changes can be made to the invention in light of the above-detailed description. In general, in the following claims, the terms used should not be construed to limit the invention to the specific embodiments disclosed in the specification and the claims, but should be construed to include all miniature resonating marker assemblies that operate in accordance with the claims. Accordingly, the invention is not limited by the disclosure, but instead its scope is to be determined entirely by the following claims.
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|Classification aux ╔tats-Unis
|Classification internationale
|Classification coopķrative
|Classification europķenne
|14 sept. 2001
Owner name: CALYPSO MEDICAL TECHNOLOGIES, INC., WASHINGTON
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GISSELBERG, MARGO;HADFORD, ERIC;DIMMER, STEVEN C.;AND OTHERS;REEL/FRAME:012186/0473;SIGNING DATES FROM 20010913 TO 20010914
|1 mai 2007
|Certificate of correction
|7 mai 2010
|Fee payment
Year of fee payment: 4
|14 nov. 2011
Owner name: VARIAN MEDICAL SYSTEMS, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CALYPSO MEDICAL TECHNOLOGIES, INC.;REEL/FRAME:027221/0245
Effective date: 20111111
|14 mai 2014
|Fee payment
Year of fee payment: 8


text:
Topic: iRedAdmin-LDAP-Pro-1.6.3 not authenticate with iredmail-0.8.5
==== Required information ====
- iRedMail version:
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iRedMail 0.8.5
Linux Centos 6.3
i have reformat my mail server and install new iredmail-0.8.5, after importing all ldap & mysql Backup. everything working fine as expected, but when i tried to migrate iRedadmin-opensource to iredadmin-pro-ldap-1.6.3 it's not authenticate with any global admin account and domain admin account please help what todo.
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subset: commoncrawl


text:
The Tories and Liberal Democrats are getting their first taste of what it might be like to form the next government even before they have agreed any kind of coalition, with the kind of civil service back-up usually only assigned to ministers.
Civil servants have been deployed to provide impartial advice on policy implementation to the parties as part of an extensive plan for a hung parliament drawn up well in advance of Thursday's election result by the cabinet secretary, Gus O'Donnell.
Every party that could become involved in the formation of a new government has been offered civil service support and separate teams have been made available. But an elaborate system of "Chinese walls" has been established between each team to ensure civil servants do not inadvertently leak party plans to their colleagues on other teams. "The Chinese walls principle is very important. You wouldn't want any of that compromised," a senior Whitehall source said.
Today's talks between the Tories and Liberal Democrats took place in the Cabinet Office, a nondescript building on Whitehall where the negotiating teams met. No civil servants were present, but a Treasury official was called in at one point to provide advice. The talks are governed by rules on elections and government formation, published in a cabinet manual by O'Donnell earlier this year, which set out the constitutional conventions around a hung parliament.
O'Donnell, a longstanding civil servant who has been permanent secretary at the Treasury and was press secretary to John Major, has won praise for his foresight and attention to detail in drawing up plans in the event of a hung parliament.
Every single department has been costing and designing implementation plans for the various parties' policies in the form of red, blue and yellow folders as is routine after an election – the latter taken far more seriously since the Liberal Democrats' bounce in the polls after the first TV debate. Ordinarily, in the days after an election, civil servants go into overdrive welcoming new ministers and briefing them on their portfolios. This time round they have instead turned to complicated grids designed for the event of a hung parliament, to calculate where the parties' policies cross over and how they might be implemented in a coalition government.
O'Donnell also ensured that parliament will be reconvened a week later than normal, taking some of the time pressures off forming the government, and the civil service has been planning scenarios and role-playing for weeks.
As the Con-Lib Dem talks were concluding this afternoon, the SNP Westminster leader, Angus Robertson, and his deputy, Stewart Hosie, attended a meeting in Whitehall where they discussed the mechanics of negotiations and requested the information necessary to support these negotiations, a party spokesman said.
Sir John Elvidge, permanent secretary to the Scottish government, has been offering his experience to Whitehall of dealing with a hung parliament in Edinburgh.
Last month O'Donnell went to New Zealand to study its system for supporting parties' negotiations in a hung parliament. Key figures in all the parties are now being briefed by civil servants. Vince Cable, the Liberal Democrat Treasury spokesman, received his first call on Friday, with Treasury officials giving him details of the economic problems in southern Europe.
A senior civil service source said: "This has been a classic example of the great British civil service preparation. Whitehall is ready and prepared to go with this. It has been a classic example of policy analysis and preparation. A lot of work has been done.
"Like everyone else right now, we're just waiting to see what happens next."
Today O'Donnell's predecessor, Lord Turnbull, said that the Conservatives and Lib Dems needed to make a decision on a possible power-sharing deal by Wednesday at the latest.
Turnbull, who headed the civil service between 2002 and 2005, warned that negotiations "dragging on and becoming acrimonious and contentious" would have a negative effect on the markets.
He told BBC Radio 4's The World This Weekend: "I don't think these discussions can go on to anything like the 18th, I think they need to be settled by Monday, Tuesday, Wednesday this week.
"I think the markets will suspend judgment if they thought serious, responsibly conducted discussions were going on, and they wouldn't expect those to reach an outcome immediately. If they saw it dragging on and becoming acrimonious and contentious, that would be an indication that whatever emerged would not be a strong basis for the taking of subsequent decisions."
Turnbull said a coalition government would be a "huge" change for the civil service. He said: "How do you adapt cabinet collective responsibility and confidentiality for the parties that you are in partnership with?
"So at the same time as the civil service helping the parties to agree on what is the programme, they also need to define the basis of the partnership – who can say what to whom, how the decisions get made, who is consulted, when and what timing."


text:
With the many restricted free agents around the NFL inked to deals, Browns head coach Eric Mangini was asked if any progress has been made with the Browns' RFAs. To date, the only one to sign is LB Jason Trusnik.
Notable unsigned restricted free agents missing are LB D'Qwell Jackson, RB Jerome Harrison, FB Lawrence Vickers and LB Matt Roth. If they do no sign their tender, they will most likely not participate in the off-season program and the upcoming OTAs.
"This is new ground for all of us," Mangini said. "Hopefully, they're here, but if they're not, then other guys will get an opportunity."
Familiarity: Mangini said that the rookie minicamp is more for getting the rookies acclimated with the NFL, than with the evaluation process.
"You really can't do a lot of evaluating other than on how quickly they pick up the information and are making the adjustments," Mangini said. "This is so different for these guys from everything they've done in the past."
The majority of the 53 players in camp were tryout players with only eight drafted players and 10 undrafted free agents being actually signed.
"Sometimes, you sign a guy that is here for a tryout and you don't know when we will meet up with them again," Mangini said. "It might be before training camp or during camp or at some point during the season."
Mangini likes to find gems in the undrafted players and was asked if any caught his eye.
"It's too early in the mining process," Mangini said. "Wallace Wright was a tryout guy at New York who came in as a tryout guy. He stayed through OTAs and made the 53-man roster, then went back to the practice squad and back to the 53. He did a good job on special teams and now signed as a free agent with Jacksonville as a wide receiver."
Mangini said he has made it a practice to not combine the rookies with the veterans on the first experience.
"I've always just brought rookies in because I want them to get comfortable with the building, the system and a combination of things."
The rookie minicamp ends Sunday, but is not open to media.
Looking at Shawn Inside: Mangini said third-round pick OL Shawn Lauvao has done a nice job in his first experience with the Browns. He will be worked on the inside at guard and even center.
"He's done a nice job," Mangini said. "He'll probably be on the inside. Again, his versatility will be important for him."
Lauvao said he is just six to nine units from receiving his Master's degree from Arizona State in interdisciplinary studies.
"The coaches have made it clear to me that I'm starting on the inside," he said. "The biggest thing for me is to learn the playbook, make the team, get better and do whatever is necessary."
Lauvao (6-3, 315) played left tackle in college, but is smaller in stature for the NFL.
"I use my leverage and have to be on point," he said. "I'm more controlled and use my finesse."
Mangini used the term 'keeping the pocket clean' when describing him on draft day.
"I help my teammates out and keep the quarterback off the ground."
Cautious Cliff: After being one of the best interviews the day he was drafted, DL Clifton Geathers was very cautious and seemed nervous when meeting with reporters for the first time. He said when he was drafted that he thought he could be one of the best players in the NFL.
He was asked about his comment and sounded as though he had been told to downplay his comments.
"I haven't played a down yet," Geathers said. "I'm a football player. My confidence is very high."
In his first practice, Geathers hit former Ohio State punter Jonathan Thoma and knocked him to the ground. Mangini scolded Geathers (6-7, 299) for hitting someone much smaller than him.
"The coach told me to go full speed and I leveled the punter."


text:
It's Friday...and I couldn't be happier. I need to get a ton of stuff done over the weekend before I head off to Vegas for work. Oh, did I not mention that I'll be blogging live from Vegas all next week for Wedding MBA? Get ready for lots of IG selfies from the strip! You've officially been warned!
As for the OOTD, today, I'm keeping it simple and bright. I picked up this gorgeous yellow jacket last holiday season at LOFT. I am so super impressed by everything that's come out of that store as of late. Never saw myself as being a big LOFT or Ann Taylor girl, but the direction they've taken in terms of design has really caught my eye. Plus, they are ALWAYS running a 30-40% off sale at any given time. (YES, GAWD!)
The top is from the Bellatrix line which you can find at Nordstrom and Nordstrom Rack. We've got TONS of Racks popping up here in Atlanta, including a new one that's opening near Perimeter Mall in October! I totes plan to be there on opening day. My necklace is from Forever 21, and I'm really sad to say it broke shortly after taking these photos. Man, I loved that necklace, too! The croc embossed envelope clutch is vintage and I grabbed from my girls at Recollection Vintage during the Salvage curate event last spring.
Lastly, my shoes are the "Marilyn" sandal by Ryan Haber and from Gregory's. I really do love these B&W platforms. I saw Carrie Underwood wearing them during a performance this summer and KNEW I had to have them. If you're ever in Atlanta, be sure to make a trip to Gregory's in Lenox Square. The salesgirls are so sweet and they have the best sales on designer kicks. LOVE THEM!
Are you happy it's finally Friday? What are your plans for the weekend? Leave a comment for me below!
Want more of my fashion finds and favorites? Follow Brains of the Outfit on Bloglovin and YouTube!


text:
UAB Hires Head Football Coach
UAB has hired a new head football coach. It's Bill Clark, the head coach at Jacksonville State. Clark went 11-4 last season. He previously served as an assistant at South Alabama. Clark was head coach at Prattville High School for nine years, winning two state championships. He replaces Garrick McGee, who left to become Bobby Petrino's offensive coordinator at Louisville after going 5-19 in two seasons.