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Moscow: The Kremlin announced on Monday that President Vladimir Putin had ordered Russian troops conducting exercises along the Ukrainian border to return to their home bases at the conclusion of the drills, apparently sending another loud signal that Russia is not planning any military action in eastern Ukraine ahead of that country's presidential elections Sunday.
However, the NATO secretary general, Anders Fogh Rasmussen, said the Western allies had not seen any sign of a withdrawal of Russian forces. During a news conference at NATO headquarters in Brussels, General Rasmussen noted that it was the third such statement by Mr Putin without any evidence of a pullback of troops or equipment from the Ukrainian border.
The Kremlin statement said Mr Putin had ordered the withdrawal of military units in conducting drills in the Rostov, Belgorod and Bryansk regions of western Russia. At the same time, it called for "the immediate halt of punitive operations and use of force" by the Ukrainian government and demanded "resolution of the various problems through peaceful means alone."
Even as a series of national round-table talks have begun in Ukraine aimed at resolving the country's political crisis, the provisional government in the capital, Kiev, has pressed on with a security operation aimed at suppressing the armed pro-Russian separatists in eastern Ukraine. The government refers to the separatists, who have seized some public buildings, as terrorists.
Sporadic violence, including injuries and deaths, has continued throughout eastern Ukraine in recent days. On Sunday night, local news agencies reported that armed pro-Russian separatists had seized a police station in the city of Luhansk.
The Kremlin's call for an end to the Ukrainian government's campaign against the separatists was reiterated by the Russian foreign minister, Sergey Lavrov at a news conference in Moscow on Monday.
"We still insist on the first unconditional step: a halt of the so-called anti-terrorism operation, which is turning into actions aimed at terrorising citizens of Ukraine just for their political convictions," Mr Lavrov said.
In a sign of the continuing mistrust, Mr Lavrov warned against any effort by Kiev to use the round-table talks as public window dressing while secretly pursuing other changes in government structure behind the scenes in Parliament.
"If the idea is to use the round tables simply as a folding screen, as a means of letting off steam, while holding the actual reform in a close manner, it will not add trust," he said.
New York Times


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~Waterfowl Wingmasters~
Decoys- 4 Dozen duck
Scouted last night and not impressed at all. But decided to go any ways. Late morning at setting up the decoys at 6:00, and shooting time being 6:30. Had a few flocks work us but nothing big. Last flock of the day and we pulled our limit of redhead out of it. Guess in time good things to happen. The good thing is that we saw some migrators, Both ducks, and geese. Can't wait till next weekend. Enjoy the pics.
http://img246.imageshack.us/img246/2613 ... 3pf.th.jpg
http://img258.imageshack.us/img258/4595 ... 7yy.th.jpg

subset: commoncrawl


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Follow Harriet on Twitter
About Harriet
- The Poetry Foundation's blog for poetry and related news.
- More about Harriet
- Contributors
- Archive
Poetry News
Nobel Prize Winning Poet Seamus Heaney Dies at 74
We awoke to the sad news this morning that Seamus Heaney has died. In the coming days we know there will be ample tributes and remembrances. For now, the RTE News in Ireland reports:
The world-renowned poet had been in hospital after suffering a short illness, a statement on behalf of the family said.
They said he died in hospital in Dublin this morning.
Mr Heaney was awarded numerous prizes over the years and won the Nobel Prize in Literature in 1995.
He was born to a farming family at Mossbawn near Bellaghy in Co Derry on 13 April, 1939.
His poetry first came to public attention in the mid-1960s with his first major collection, Death Of A Naturalist, published in 1966.
As the Troubles in Northern Ireland took hold later that decade, his experiences were seen through the darkened mood of his work.
The writer is survived by his wife Marie and children Christopher, Michael and Catherine Ann.
Over his long career Heaney contributed both poetry and translations to Poetry magazine. He will be sorely missed.
Tags: Obituary, Seamus Heaney
Posted in Poetry News on Friday, August 30th, 2013 by Harriet Staff.


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This is something I would also like to know. I've always loved my teachers but I've always hated the school system. Science is not about memorization. School should be about the joy of learning. As I see how my younger cousins are educated in school, or even younger people about 3-6 years younger than I. It is becoming ever more apparent that what we have is a system that would like to propagate society as it is. and for all the beauty and the joy that the society I am in has brought to me, I cannot but hope that society progresses and for it to progress we must learn to subvert the things that try to propagate this system I have come both to love and hate.
They say crazy is doing something again ang again ang expecting different results. So I say that we are crazy to believe that the world is not changing, and because the world is changing it is crazy to expect that the way that society progressed what starting 150 years ago up to the present is the way for us to progress even more. We need a modern system of educating people. We have sold the arts short by not teaching it well. We have sold science and math short by not showing people how beautiful it is.
I hope that by the time I have a child, I wouldn't have to put up a herculean effort just to give my child a proper education.!
What interests me is whether the present system actually produces more success or heavily limits it.
Would a different system with less emphasis on conformity produce more of our best and brightest? Or does the annealing effect of being crushed by the system help to produce those best and brightest?
If you look at those who have commonly advanced our thinking, our abilities, our technologies, and our economy (through business sense), many did poorly in schools, yet they persisted. The persistence may have been the critical element, and it would have perhaps been lost had they been encouraged more.
So does this mean we need more of those mediocre middle school and high school teachers acting as the forge to both create the worker bees we need, as well as the best [and most successful] by trying to destroy them?
Do Good Grades Predict Success? – Freakonomics – Opinion – New York Times Blog.


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The Supreme Court has ruled that money lost betting on horses can for tax purposes should be considered expenses deductible from winnings.
The court's Third Petty Bench, with Kiyoko Okabe as the presiding justice, rejected the prosecution's claims that a 41-year-old man from Osaka Prefecture evaded ¥570 million in taxes by failing to declare income from betting on horse races.
The ruling on Tuesday upholds decisions by lower courts that sentenced the man to two months in prison, suspended for two years, for evading ¥52 million in tax.
According to the top court's ruling, the man bet several million to tens of million yen per day online on weekend horse races across Japan over many years using specialized software.
The total amount of bets made between 2007 and 2009 reached ¥2.87 billion, while his winnings stood at ¥3.01 billion.
The man managed "sizable winnings by betting in an inclusive manner over a long time without caring about the results of individual bets," according to the Supreme Court's ruling.
The winnings should be considered miscellaneous income, instead of temporary income as the prosecution claimed, according to the ruling. Tax authorities accept larger amounts of tax-deductible expenses for miscellaneous income than for temporary income.
The nearly indiscriminate bets should be considered integrated economic activity, the Supreme Court said, explaining the reason for its decision.


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Soon, climbbybike will present the best bike for climbing for the year 2014 on this page. In the selection, a number of elements play a role like the weight of the frame, the torsional stiffness and bracket stiffness (a climb is usually followed by a descent) and the groups that can be put on the bike. And although rather personal of course, it helps that the bike looks good.
When cycling uphill, of course, your gear is essential. To mount a big col it can, especially for novice cyclists, be recommended to opt for a "triple". A triple is a bike with 3 sprockets in front. Make sure the chain runs always in a fairly straight line between the front and rear sprockets.
A triple can go as far as 1 to 1. That is to say that the number of front and rear tooths are equal (e.g. 30/30) and your wheel does exactly one turn per crankshaft revolution (for a racing bike usually 2100 mm).
If you want to go even smaller, you better buy a mountain bike with mountain bike gear.
It is important to find a good cadence. For most climbers, a good cadence is between the 65 and 70 revolutions per minute. Climbing is controlling your heart beat and cadence!
Determine cadence and gear by your expected speed.
* FIRST fill out your speed, NEXT select your front gear
Choose a bike with a bicycle frame that fits your size. To tell you the size of your bike frame you can use the following method:
racing bike: inseam x 0.665
mountain bike (hard tail): 0.226 x inseam
The inseam is the length off the ground to your scrotum (without shoes).
Make sure your brakes work properly, because an ascent is usually followed by a descent. Make sure to have a helmet, also not unnecessary uphill. And cycling shoes are also essential. Make sure the plates under your shoes match your pedals, because there are different systems (Look, Shimano, Time ...).
A bike computer and heart rate are helpful during your preparation and on some (e.g. the Garmin Edge series) you can post climbing routes. Download them via climbbybike!
© climbbybike™ All rights reserved 2005 -


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Top news links, courtesy of Mountain West News.
Decision on wolf trapping in Montana near Yellowstone NP in judge's hands
After the Montana Fish, Wildlife and Parks Commission suspended trapping in two zones near Yellowstone National Park over concerns that too many wolves used in research were being killed, state Rep. Alan Redfield, Citizens for Balanced Use, Big Game Forever and Montana Sportsmen for Fish and Wildlife challenged the decision, and the ban was temporarily lifted, and at a hearing on Monday, state District Judge Brenda Gilbert heard from both sides on whether the ban should be implemented or permanently lifted.
Billings Gazette (AP); Jan. 15
Groups urge Montana to hold hearings in cities affected by coal train traffic
The Montana Departments of Environmental Quality and Natural Resources and Conservation are holding three meetings this week in Eastern Montana on the proposed Otter Creek Mine, but 17 environmental groups are urging that, since the coal will be exported, that hearings also be held in Helena, Bozeman, Billings and Missoula, through which coal trains will pass.
Billings Gazette (AP); Jan. 15
Group urges USFS to shut regional office, not merge Wyo., Idaho forests
The Jackson Hole Conservation Alliance sent a letter last week to U.S. Forest Service Chief Tom Tidwell, asking that the agency reconsider closing the regional office in Ogden, Utah, to save money rather than proceed with a proposal to merge the Bridger-Teton National Forest in Wyoming with the Caribou-Targhee National Forest in Idaho.
Jackson Hole Daily; Jan. 15
WildEarth Guardians sue EPA over plan to curb haze in Wyoming
In a lawsuit filed Monday in federal court in Denver, WildEarth Guardians challenged the U.S. Environmental Protection Agency's plan to curb haze in Wyoming, because the plan sets emission limits from coal-fired power plants in the state at a level that they can already meet.
Casper Star-Tribune; Jan. 15
NEB hearing on Northern Gateway Pipeline in B.C. draws protesters
At the first National Energy Board public hearing in Vancouver, B.C., on the proposed Northern Gateway Pipeline that would carry oilsands from Alberta to a port on the B.C. coast, hundreds of protesters representing First Nation, environmental and other groups rallied outside the meeting room.
Calgary Herald (Vancouver Sun); Jan. 15
Oregon senator seeks information on coal royalties, export plans
In an interview with Oregon Public Broadcasting, U.S. Sen. Ron Wyden said his inquiry into the nation's coal business involves two issues: Are coal producers paying the correct amount of royalties on the coal they pull from public lands, and should the nation be exporting coal to Asia. The article contains 10 facts about coal production in the Powder River Basin in Wyoming and Montana.
OPB.org; Jan. 15
Montana event provides details of life in the oil boom
At the "Boom or Bust: Social Impacts of Oil and Gas Development" event in Great Falls on Monday, representatives of communities that are dealing with the energy boom, shared their stories about how that boom has changed their communities.
Great Falls Tribune; Jan. 15
Mountain West News is a project of the Center for the Rocky Mountain West at The University of Montana. It provides a daily snapshot of news and opinion in the Rocky Mountain region of North America, giving the changing mountain West a tool to understand itself and a platform for the exchange of ideas.


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Oregon Historical County Records Guide
Douglas County Scenic Images
Tahkenitch Lake
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An arm of Tahkenitch Lake near the coast. (Photo No. douDA0184)
About this image
Dimensions: 3872 x 2571 pixels (300 dpi version); Date created: August 2009; Camera: Nikon D80 Digital SLR; Lens: Nikon AF-S DX Zoom-Nikkor 18-135mm f/3.5-5.6G IF-ED; Photographer citation: Gary Halvorson, Oregon State Archives; Keywords/Tags: horizontal, Oregon, Douglas County, Tahkenitch Lake, arm, dock, boats, dark water, blue sky, U.S. Highway 101, trees.
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County guide home | Scenic images home


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It seem all of these reports are showing the BGs loosing in shoot outs. Great!
This is a discussion on Homeowner - 1, Armed Intruder - 0 within the In the News: The Good, the Bad and the Ugly forums, part of the The Back Porch category; http://www.news-journalonline.com/Ne...fire121807.htm PALM COAST - A man was shot to death Tuesday night outside a home on Pheasant Drive after a gun battle with a resident ...
PALM COAST - A man was shot to death Tuesday night outside a home on Pheasant Drive after a gun battle with a resident of the home, authorities said.
Flagler County sheriff's officials are withholding the name of the slain man, who appears to be in his 20s, until family members can be notified.
Deputies were called to the home at 43 Pheasant Drive shortly before 7 p.m., Chief Deputy Rick Look said.
They found what appeared to be a case of self-defense initiated after the man entered the home "uninvited," Look said.
The two residents, a man and woman whose names were not released, told investigators the man entered their home through the unlocked front door. The male resident "grabbed a gun and fired it at the intruder," Look said.
The intruder ran out the front door, turned around and fired a gun at the residents, Look said they told investigators.
The male resident returned fire, Look said.
Investigators aren't sure which shot was the one that killed the man, causing him to fall outside the home.
Look said they can't be certain until further investigation but investigators don't think the event was random.
"We're trying to determine if there's a relationship between the victims and the suspect," Look said.
The Florida Department of Law Enforcement was called in to assist the Sheriff's Office and process the scene, Look said. And even though the shooting ended outside in plain view of neighboring homes, "neighbors didn't see anything," Look said.
"I heard something," a woman who lives across the street from the home said. "I just thought it was firecrackers, though."
The resident declined to give her name but said the experience was "pretty freaky" for her. She moved to Palm Coast from Miami, and although there's more crime in South Florida, "it was never this close to home," she said.
Investigators are also looking into what a neighbor called a "suspicious silver Hyundai" that was parked across the street from the home for three days.
"It didn't move, and now suddenly it's gone," the woman said.
Good on the homeowner for being armed and prepared. The newspaper didn't release the name of the victim, but sure released his address. Will they ever get it? I doubt it.
"The natural progress of things is for liberty to yield, and government to gain ground."
- Thomas Jefferson
"I'm the arrow, you're my bow, shoot me forth and I will go"
"Do not let any individual posts put a knot in your Big Boy Under-Roos"
It seem all of these reports are showing the BGs loosing in shoot outs. Great!
Hopefully, this is as reported, and is a good shoot. The possible relationship between shooter and shot may complicate things, however.
A man fires a rifle for many years, and he goes to war. And afterward he turns the rifle in at the armory, and he believes he's finished with the rifle. But no matter what else he might do with his hands - love a woman, build a house, change his son's diaper - his hands remember the rifle.
"Deputies were called to the home at 43 Pheasant Drive shortly before 7 p.m., Chief Deputy Rick Look said."
Yep, the local rag had to print the address of the shooter.
I guess my question is did the BG fire at the front door at the GG in the house or did he fire while running away in the front yard with the GG giving chase?
Another one bites the dust,
Another one bites the dust.
And another one's gone,
And another one's gone,
Another one bites the dust.
Hey Hey!!
That is what happens to ya when you go into a home that is not yours. That is what should happen to every piece of garbage that goes into a home where they don't belong. Either the homeowner gets ya, or the law gets ya. Excellent outcome.
A person is justified in the use of deadly force, if such person reasonably believes deadly force is necessary to prevent imminent death or great bodily harm to such person or a third person.
Another robbery gone good!! And it happened outside so the homeowner won't be stuck with a big bill cleaning up the criminals blood!
"It does not take a majority to prevail,,,,,,but rather an irate, tireless minority, keen on setting brushfires of freedom in the minds of men." Samuel Adams
This just in...
Oh wait a minute, it's in the title of the post...but still another great score!
Stay armed...stay safe!
Proverbs 27:12 says: The prudent see danger and take refuge, but the simple keep going and suffer for it.
Certified Glock Armorer
NRA Life Member


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DMACC and YMCA-Ankeny Plan Rec Center
Des Moines Area Community College President Rob Denson says rising enrollment, and more student housing near the Ankeny campus has created a need for more recreational space.
Officials with the current Ankeny YMCA, located at Northview Middle School, say they could use more space too, and a more updated facility.
The two entities are now pooling their resources, and making plans to build a student "rec" center, which would also serve current YMCA members in the community.
Denson says if all goes well, construction will begin a year from now.
The total cost is projected to be 23-(m) million dollars.
It has not been determined if students will pay a monthly fee, or if membership will be included in their student fees.


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Peter Coy in the May 11th 2009 Business week issue wrote this article "help wanted" describing the 3Million jobs currently (as of beginning of March 2009) out there in USA that folks are having a difficult time filling up: http://www.businessweek.com/magazine/content/09_19/b4130040117561.htm?campaign_id=rss_daily
This 3Million number maps to bureau of labor statistics JOLTS report, conference board, etc.
The openings are in accounting, health care, government, and education...
Challenges described include lack of right skills, people not being able to relocate due to the housing challenge...
So what if the government and entrepreneurs start leveraging smarter collaboration capabilities to
(a) train people on new skills?
(b) go mobile, work from home/remote?
Can Smarter Collaboration help fill the 3 million US jobs open TODAY?
AntonySatyadas 1100009CNT Tags:  jobs businessweek collaboration smarter 2,759 Views


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Falls Church, Virginia (VA) Connecting Your Computer To Your TV – How To Connect Your Computer To Your TV, Falls Church Virginia (VA)
***We provide onsite Computer Repair and Network Support for home and business in VA, MD and DC. Please, call us toll free 877-433-5222 or fill out the Service Request Form to schedule an appointment. We have put a blog below that you may find useful knowledge about computers, services and products.***
Falls Church, Virginia (VA) Connecting Your Computer To Your TV – How To Connect Your Computer To Your TV, Falls Church Virginia (VA)
With the increasing ability to watch movies online or desire to view your photos on a larger screen, one thing you can do to get more enjoyment out of your computer is to connect it to your TV for viewing. Geek ABC is a locally owned and operated computer and network service and repair company who can help you accomplish this if you haven't been able to figure it out on your own. We can be reached via our website www.geekabc.com or give us a call at 1.877.GEEKABC (1.877.433.5222) for more information or to schedule an appointment.
Most computers, these days, have a video card with a TV out connection but you have to make sure that both your computer and your TV have compatible connections. There are five basic ways you can connect you PC to your TV.
- S-Video
- Scan Converter Box
Connecting your computer to your TV can be quite a luxury because it can get difficult watching movies on a 17" screen and with the holidays coming up it will be nice to show family photos on a big screen without having to transfer them on to a disk. Another benefit to connecting your PC to your TV is for internet use. It's funny; the amount of people who sit on their sofa's and search the internet or watch movies and TV shows that they have downloaded on to their laptops, when they have a huge HDTV sitting just a few feet in front of them. Why not connect your laptop or computer to the TV for better viewing? This is something that everyone should look in to if they spend countless hours in front of their computers or laptops at home.
Tags: DVI, HDMI, S-Video, Scan Converter Box, VGA


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Complete Processing with only One Machine
Conventionally the processing of components is carried out in various machines and successive process steps. Each machine must be set-up, the parts transported and loaded into the machine. This costs time (set-up, transport and loading time) and money (personnel and machine costs). As part of a BMBF project Monforts and various partners developed the KombiMasch concept that reduces process time substantially, reduces the production costs significantly and at the same time, due to one set-up, increases product quality.
The KombiMasch modular machine concept, implemented in Monforts UniCen series makes the complex complete processing of components in only one machine tool possible. Through the integration of a laser it is possible to perform the following process steps one after another: soft machining (turning, milling, drilling), hardening and surface treatment as well as hard machining (turning, milling). The whole operation is controlled by a continuous CAM machining program. This brings clear time and cost advantages! It is possible to react more flexibly to customer requirements and challenges, for example in the case of time sensitive spare parts.


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How to Buy
Solutions Overview
This script is Copyright (C) 2007-2016 Tenable Network Security, Inc.
Synopsis :
The remote Red Hat host is missing one or more security updates.
Description :
Updated libgsf packages that fix a buffer overflow flaw are now
This update has been rated as having moderate security impact by the
Red Hat Security Response Team.
The GNOME Structured File Library is a utility library for reading and
writing structured file formats.
A heap based buffer overflow flaw was found in the way GNOME
Structured File Library processes and certain OLE documents. If an
person opened a specially crafted OLE file, it could cause the client
application to crash or execute arbitrary code. (CVE-2006-4514)
Users of GNOME Structured File Library should upgrade to these updated
packages, which contain a backported patch that resolves this issue.
See also :
Solution :
Update the affected libgsf and / or libgsf-devel packages.
Risk factor :
High / CVSS Base Score : 7.5
CVSS Temporal Score : 6.5
Public Exploit Available : false
Family: Red Hat Local Security Checks
Nessus Plugin ID: 24211 ()
Bugtraq ID: 21358
Get Nessus Professional to scan unlimited IPs, run compliance checks & more
The cookie settings on this website are set to 'allow all cookies' to give you the very best website experience. If you continue without changing these settings, you consent to this - but if you want, you can opt out of all cookies by clicking below.


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2004 X5 Nav Radio not working
View Single Post
Registered User
Location: newburgh NY
Join Date: Oct 2010
Posts: 79
Mein Auto: 2002 bmw x5 3.0i
View My Garage
Originally Posted by
so i know this has been covered several different times and several different answers. happened to me today. I checked all three fuses, 7, 72, AND 73, all were good. i then removed the nav screen to see if all connectors were ok, all were. i then went to the amp removed and reconnected all connectors, still nada. i then looked and looked on several forums and found a guy who showed me pics and details of the actual radio, which to my suprise was not the nav screen...it was located in the trunk, under the spare tire, under a plastic cover. many screws and bolts later, i located the radio, which was only fastened by one screw, with two connectors on top. i removed the radio and suprise suprise, there was an inch or so of water laying next to the battery and the front of the radio was submerged. it had rained yesterday and then suddenly went out. i took it completely out of the car, checked the 10a fuse which was ok, then took the metal cover off the radio, sprayed dust off and saw water running out the side of it. i let it sit in the sun for about an hour with the cover off, reconnected, and bam..it worked! very happy, as that radio piece goes for $400-800 on ebay! whew.. it is a dys project, but takes alot of patience and testing. thanks for all that have gave input on this matter...\WIll
and this is under the spare tire under the black plastic cover that reads BMW right?i heard of this but does this apply to only DSP Models? I have removed that cover before and all i found were just empty harnesses, which made me think that most people that have this issue have DSP equipped cars, or maybe is it some where else under the cover and i over looked it?
View Public Profile
Find all threads started by aimtimes100
Find all posts by aimtimes100
View My Garage
Add aimtimes100 to Your Ignore List


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It's time for Santa to come to Vancouver and Hyack Festival Association will be there, in cooperation with the City of New Westminster, to greet him and all the children lining the parade route at the 10th annual Rogers Santa Claus Parade. Hyack was pleased the City welcomed the organization's request to participate with the float in this iconic winter celebration of the holiday season.
With the cooperation of the City of New Westminster it was agreed that the Hyack float entitled 'Celebrate Our History' would make its traditional appearance in the Rogers parade which attracts up to 300,000 people. "Hyack has been a presence in this parade for many years and we thank the City for working with us to continue this seasonal tradition. Hyack takes seriously our responsibility of introducing the city of New Westminster to the people in surrounding communities and regions. We are proud of our city. It is an honour for the board and past presidents to walk beside this beautiful float focusing the attention of hundreds of thousands of people on New Westminster." conveys Palmer.
We invite all New Westminster children, and their parents, to join us Sunday, December 1st, 2013 at 1:00PM as we march in the parade that ushers Santa back to Greater Vancouver. The 10th annual Rogers Santa Claus Parade starts at Georgia and Broughton, travels east on Georgia to Howe, turns south on Howe, and finishes at Howe and Davie.
"I know of no other marketing effort at this time of year which puts the city of New Westminster before such a massive audience. To see the smiles on the children's faces as they anticipate the arrival of Santa makes this effort by many New Westminster volunteers extremely worthwhile." reveals Palmer. For more information on the parade please visit http://rogerssantaclausparade.com/parade-day/.


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Chevening Scholarships
Chevening Scholarships are the UK government's global scholarship programme, funded by the Foreign and Commonwealth Office (FCO) and partner organisations. The Scholarships are awarded to outstanding scholars with leadership potential. Awards are typically for a one-year Master's degree, in any subject and at any of the UK's leading universities.
The Chevening programme began in 1983 and has developed into a prestigious international scheme. Chevening Scholars come from 116 countries worldwide (excluding the USA and the EU), and this year the Scholarships will support approximately 700 individuals. There are over 41,000 Chevening alumni around the world who together comprise an influential and highly regarded global network.
The Chevening Scholarships website enables you to register your interest to receive alerts about application opening and closing dates and candidate guidance, and find out about priority subjects for countries which offer Chevening Scholarships. In addition to giving details of the Chevening application process, the website provides updates about latest developments in the scheme worldwide, and important information on applying for higher education courses in the UK more generally.


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Hex Editors
In this context, "hex" stands for "hexadecimal," the low level, machine-friendly base-16 notation system used in many computer programs and codes.
In theory, a "hex editor" can let you see and modify anything and everything anywhere on your hard drive, including any and all kinds of files and their contents, and even the disk's own fundamental data structures.
Hex editors also are useful for exploring mystery files that you can't open by any other means: A hex editor will let you see what's in almost any file, and sometimes can provide enough clues so you can figure out what an unknown or unopenable file is, or where it came from.
File-oriented hex editors also often are optimized for the recovery of accidentally deleted files; they can let you find, identify, rename, and save (as a new file) anything that was mistakenly erased.
Some hex editors are geared to other special purposes, such as manually sorting out problems with the boot process or with partitions and logical disks; including unformatting, unpartitioning, or finding/undeleting lost partitions.
While task-specific hex editors can make certain tasks easier (mostly by pointing you in the right directions), general-purpose hex editors can do it all, letting you view -- and optionally modify -- anything that's anywhere on your hard drive. This kind of hex editor is often used in digital forensics and in heavy-duty file- and disk-recovery: It will show you absolutely everything on the hard drive -- including every file, every deleted file, and even bits or scraps of data left over outside the active, in-use file areas. This can include residual data from deletion or defragging operations; data in normally unviewable areas (such as the swapfile or pagefile); and data left in the "slack" space after an end-of-file marker. (If these concepts are unfamiliar to you, see the information here , here, or here.)
The flip side is that general-purpose hex editors show you so much "raw" data, they can be hard to use, especially if you've never used one before. The special-purpose editors may have simpler, easier-to-use interfaces, as long as you're using them for their more-limited intended purpose.
But the above three general categories aren't at all rigidly defined: under the skin, all hex editors share some basic similarities. The differences from one editor to the next reside mostly in what functions are being optimized and emphasized, and how the front ends or interfaces are built. When push comes to shove, a general-purpose editor can be used for something like editing boot records, for example; and a drive-oriented editor may be used for editing specific files.
One thing all the editors share in common is that they can be quite slow when you're searching today's huge hard drives. That's not the fault of the editor, but simply a reflection of the amount of data they may have to process. Plus, all hex editors can be dangerous and must be used with care -- they give you the power to modify almost anything on the hard drive, including things best left alone. Many hex editors come with some form of disk imaging built in; or at least come with the strong recommendation to make an image by some other means before attempting to use the editor. (With a fresh image, you'll be able to recover from any mistakes or errors.)


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SNL Digital Short: When Will The Bass Drop?
I'm not a big SNL guy, but when Andy Samberg puts out these SNL Digital Shorts it is pure genius. Now I know almost nothing about the EDM (Electronic Dance Music) world. I know the names of a couple of the major DJs and I know Skrillex only because he fronted an emo band that was well known in the emo punk-rock scene. But I think my lack of knowledge on EDM culture makes this video funnier. Because when you're on the outside looking in, this is exactly what it looks like.
I do sometimes wonder what the DJ is doing up there. Now my question has been answered. Frying eggs, playing Jenga, and doodling pictures. It makes so much sense. Oh, and Lil' Jon is so happening right now!
Then someone also sent me this video. It's also pretty funny. I'm sure these DJs are all very talented. I wouldn't even know where to start when it comes to composing EDM music. But still, it's all very funny when not taken too seriously.


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We've got some big news! Winners for The 2013 ALTY Awards have been decided.
You the voters have spoken and you've chosen this year's best senior care and assisted living blog posts and articles from across eight different awards categories. And you spoke loudly, with almost 5,000 votes being cast over the course of the three week voting period. And it was an exciting competition with many winners being decided by only a handful of votes.
So who are the winners? (drum roll please……) Here are your 2013 ALTY Award Winners!
- Best Aging in Place Article: Aging in Place Misconception — by Louis Tenenbaum, louistenenbaum.com
- Best Alzheimer's Article: Alzheimer's Communication — Touching Foreheads and Kindness — by Bob DeMarco, The Alzheimer's Reading Room
- Best Baby Boomer Article: The Baby Boom Bump – by Kenneth S. Baer and Jeffrey B. Liebman, NYTimes op ed
- Best Senior Care Giving Article: A Caregiver's Credo for 2013 — by Carrie Steckl, ChicagoNow.com
- Best Senior Finance Article: Seniors: Helpful Tips to Reduce Your Risk of Being Scammed — by Rick Banas, BMA Management Blog
- Best Senior Healthcare Article: Overtreatment is Bad Medicine for Seniors — Charlotte Bishop, Creative Care Management blog
- Best Senior Home Article: Beyond Care at Home: When Home is NOT the Best — Bob Larkin, AlzCareBlog.com
- Best Senior Technology Article: In Touch with iPads — Nicole Francis, Provider Magazine
We also announced runners-up and finalists in each category as well. To see all the final results and how the voting shook out in all awards categories, just click a category link below:
- Aging in Place Articles
- Alzheimer's Articles
- Baby Boomer Articles
- Senior Caregiving Articles
- Senior Finance and Legal Issue Articles
- Senior Healthcare Articles
- Senior Homes Articles
- Senior Technology Articles
Congratulations to all winners, runners-up and finalists. And special thanks to everyone who voted and helped make this year's ALTYs a rousing success
Did You Win an ALTY?
Were you a winner, runner up or finalist in this year's ALTYs? Let the world know about your achievement by placing a custom badge on your website that you can find here:


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Queen and Adam Lambert to tour the US!
Queen had their big press conference yesterday at Madison Square Garden, and announced a US tour with Adam Lambert, who will once again be fronting the band. They'll have one show around here…July 19 at Mohegan Sun Arena! Here they are performing at the I Heart Radio Music Festival!


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Wilmer Optical & Vision Center
Welcome to Wilmer Optical and Vision Center, Johns Hopkins' official purveyor of the latest in eyewear and contact lenses. Wilmer Optical has eight convenient locations throughout central Maryland to best serve you. Our opticians and optometrists offer their on-site expertise with the quality you have come to expect from the Wilmer Eye Institute at Johns Hopkins- repeatedly named one of the best in the country. At Wilmer Optical, you will find:
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Monday, December 12, 2011
How long will Willingham wait?
Waiting to open gifts...
Waiting to travel...
Waiting to see family...
Or in some cases maybe just waiting for it all to be over...
The Twins are in the midst of their own holiday waiting game with their top free agent, Michael Cuddyer. During last weeks Winter Meetings, the Twins put an offer on the table for three-years and about $24 million for the first time All-Star in 2011. This was a low offer from what Cuddyer was expected to get on the open market this year. That offer was made on Tuesday and the Twins have been left in the dark as what their right-handed power bat plans to do for 2012. With Cuddyer's wife giving birth to twins in the middle of last week, there have been other pressing issues on his mind. Still, the Twins are left waiting for a response on what is supposedly their best offer.
Another figure who is left in the dark waiting is free agent outfielder Josh Willingham. It seems the Twins have been in talks with the right-handed hitter to sign with the club if Cuddyer were going to leave for another team. Many of the same teams rumored to have an interest in Cuddyer or also interested in Willingham. They are both right-handed hitting, play outfield, 32-years old, and it sounds like each player is looking for at least a three-year deal from they will sign with for next season.
Willingham is a career .262 hitter who spent all of last season hitting in the catacombs of Oakland. Even with the challenges of hitting in a giant ballpark, he still managed to smash a career high 29 home runs in 2011. By adding the extra power, Willingham posted his worst batting average for his career and he struck out a career high 150 times. On the defensive side of the ball, he has played in left field for most of his career but he does have a handful of inning in right field.
The Twins have been waiting for Cuddyer to make his decision. But for Twins fans the more important questions could be, how long will Willingham wait?
It's nice for the Twins to currently have a back-up plan if their deal with Cuddyer falls through the cracks. But what would happen if the Rockies or the Indians made a hard push for Willingham in the next couple of days? He might be waiting for Cuddyer to sign and set the market so he can pick from the remaining teams. This could also leave him as a more sought after asset as a couple of teams could be fighting over his services. The scary situation for the Twins could be that Willingham and Cuddyer both sign elsewhere. This could leave the Twins with their back-up plan to their back-up plan and that man could be Jason Kubel.
Another situation to consider is the two draft picks the Twins would receive in compensation if Cuddyer were to sign with another team. There are parts of the Twins farm system that could use a couple of nice prospects to help the organization to restock. Willingham could be a comparable alternative to Cuddyer and the team would get the draft picks as a bonus. It also sounds like Willingham would be willing to sign for less money. So in a year where the team is trying to lower their payroll, it might be in the team's best interest to save a few million by signing Willingham.
So far this offseason, there has only been one slugging right-handed bat that has come off of the market. Albert Pujols signed a huge deal with the Angels at the end of last week. Now some of the other players like Carlos Beltran, Aramis Ramirez, and Cuddyer could be in the next group to sign on the dotted line. Teams that failed to get Pujols were turn their attention to other options and this could open up new markets to players like Cuddyer. This means, the waiting game could play out in his favor especially if the Twins are not able to increase their offer to Cuddyer.
Twins fans might be sick of waiting this holiday season...
but they may have to wait a little longer for a resolution to the Cuddyer situation.
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I hope everyone had a relaxing and enjoyable Father�s Day! I am proud to announce that the City of New Haven has been named as one of the top 20 overall performance markets in the nation during this recession according to the most recent Brookings report. This speaks to the unprecedented economic and developmental growth we have all witnessed in the City in past years. If you would like to view the report, click here.
Also, the Office of Economic Development has launched a new departmental website, providing information on key development projects as well as other useful resources for business. The website should facilitate the sharing of information with residents, the business community and those outside of New Haven. You can access the new website here.
I would like to extend my congratulations to Mike Piscitelli and Jim Travers from Transportation, Traffic and Parking, along with Mason & Co. for winning �Best in Show� and �Best Community Campaign Non-Profit� at the 2009 Mercury Awards last week for the Street Smarts campaign.
I encourage everyone to take advantage of the following activities and events taking place in the upcoming week:
Opening of the Splash Pad at Scantlebury Park
Earlier today, I celebrated the grand opening of Scantlebury Park�s splash pad. This is one of 10 splash pads located in the City that will serve New Haven youths throughout the summer. For a complete list of the City�s splash pads, please visit: http://www.cityofnewhaven.com/Parks/recreation/.
Farmington Canal Trail Public Meeting
Come to the G-2 Hearing Room at 200 Orange St. to discuss Phase IV planning of the Farmington Canal Greenway Trail. This public meeting will take place on Wednesday, June 24th, 2009 from 6-8 p.m.
Favorite Poem Community Reading
On June 25th at 5:30p.m., join Literacy Volunteers and New Haven Reads Book Bank will present readers from Dixwell, Newhallville, and Science Park for an inspiring poetry reading. The event will take place at 4 Science Park.
Dwight/Edgewood Project 2009
Yale School of Drama students will perform one-acts by students from New Haven Public Schools at the Off Broadway Theatre on June 26th and 27th from 7-8 pm.
International Festival of Arts & Ideas
The Festival continues until Saturday, June 27th! If you have not had the opportunity, make sure to stop by and observe the enriching exhibitions, performances, lectures, and tours on schedule for this week. For more information, please visit: www.artidea.org.
Twilight Tuesdays Concert Series
Come catch the Twilight Tuesdays Concert Series in the Park of the Arts, located behind the Neighborhood Music School. Dinner will be served at 6:30 p.m. and the concert commences at 7:15 p.m., rain or shine. For tickets, call 624-5189 ex. 15 or 24. Visit http://www.nmsmusicschool.org for more information.
Green Tip
Washing your car? If you wash your car in the street, the water enters the storm sewer system and can contaminate local water bodies. Use a biodegradable soap that does not contain phosphates or chlorine and wash the car on a permeable surface like grass or gravel. Another alternative is to use a commercial car wash, as these are not allowed to discharge into storm drains.
Is someone you know interested in receiving the Mayor's Monday Message? To join this list, please send your name and email address to: firstname.lastname@example.com. An opportunity may exist down the line to receive messages specific to your neighborhood. For this purpose, in your email, please tell us what ward you live in.
The Mayor's Monday Message list is not shared with any outside groups and is used solely for the purpose of delivering timely information about issues and events in the City from the Mayor's office to your inbox.
Have a happy and healthy week,
Very truly yours,
John DeStefano, Jr.
Contact Name: Jessica Mayorga
Contact Email: firstname.lastname@example.com
Contact Phone: 2039467660


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Wills Watch: It's the last week of full-time forecasting for WAVE's Tom Wills. The station is running tributes throughout the week. Could that be why the weather's so nice?
KDP Turns to Fossett: We're glad to see our former co-worker, Liz Fossett, on the 2007 Bruce Lunsford campaign join the Kentucky Democratic Party as a communications staffer. They need her help. [Page One]
Another Blonde: The new reporter at WLKY-TV is Karen Robey, even though the graphic lists her as Karen Brown in this report on that J&J Smoke Shop murder. She's returning to WLKY for her second stint on the air. [WLKY-TV]
Fancy Farm Attendance: With Jim Bunning out of the picture, we're not sure if Fancy Farm becomes more or less important. We'll say more. Especially when it comes to speeches by Trey Grayson and Rand Paul, the likely GOP candidates to run for his seat. Still, local TV stations are mulling decisions on whether or not to send crews to the big political party.
Better Than a Homeless Shelter: Renovations are nearly complete in the first section of buildings on East Market Street, and tenants should be moving in by October. [Broken Sidewalk]
Golden Poo is Already Flying: These are going to be better than those Emmys, so nominate somebody. Or just join in the hilarity. [Golden Poo]


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Video: Maheeda Is Back!!! Goes Nekkid and dances dirty to Mbryos Song [+18]
It is had to believe that a lady who claims to be married and has a daughter will expose her body so cheaply.., She took her clothes off and bared her boobs in the video http://ireporterstv.co/ir_fullvideo/maheeda-dances-to-mbryos-song/
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Somto Monanu
About The Author: Somto Monanu
Just an 18 year old Blogger, Founder Millsmusicent.com, Accidental Rapper, Bill Gate's Number One fan infact i be Entrepreneur!
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- Chioma Chukwuka & Police Officers Fight Silly in Enugu - June 4, 2014


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The Neffs National Bank offers three different types of checking accounts: Regular Checking, NOW Account, and Super NOW Account. Checking account customers are required to pay for the printing of checks and deposit tickets. With a wide variety of checks to choose from, you can pick the style that best meets your needs.
Free Checking Account
Our Regular Checking account has the following features:
- No minimum balance
- No monthly service fees
- Unlimited check writing privileges
NOTICE: By federal law, as of 1/1/2013, funds in a non-interest bearing transaction account (including an IOLTA/IOLA) will no longer receive unlimited deposit insurance coverage, but will be FDIC-insured to the legal maximum of $250,000 for each ownership category. For more information visit *https://www.fdic.gov/deposit/.
Interest Checking
For our customers who prefer the benefits of our checking account plus earned interest, we offer interest bearing checking accounts. The features of these accounts are:
NOW Accounts
- $1,000 minimum balance
- $5.00 per month charge if balance falls below the minimum**
- $0.15 per check charge if balance falls below the minimum balance**
Super NOW Accounts
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- $0.15 per check charge if balance falls below the minimum balance**
**Fees could reduce the earning on these accounts.
To view our current rates click here or for more information contact us at 610-767-3875


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- The Poetry Foundation's blog for poetry and related news.
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Poetry News
Who Says that Poets Don't Like Futbol?
We're still reeling from yesterday's US v. Portugal match. What a game, right? Well, at Paris Review poet Rowan Ricardo Phillips has been covering the Cup. Check it!
The same day that, in Chile, more than twenty previously unknown works by Pablo Neruda were discovered in the most unlikely of places—a drawer—Spain thought it was a good idea to continue their monarchy by changing the constitution so the prince could replace the abdicating king. I rejoiced at one and shrugged at the other. Fittingly, Chile beat Spain 2-0 yesterday.
Chile showed the extent to which Spain is past its sell-by date. Spain has become a product, a collection of starry names to sell to a depressed populace. The sales pitch used to work: they won the Euros in 2008, the World Cup in 2010, and the Euros again in 2012, an unprecedented streak. But what worked then never evolved into what will work now. Most of the players from 2008 were in Brazil in 2014: the goalkeeper Iker Casillas was benched by his club team for the majority of the past two seasons, yet started in this World Cup. His place was barely questioned. Of course he wanted to play: Spain has more than 50 percent unemployment for adults twenty-five and under; the players stood to win a bonus of 720,000 euros each if they won this World Cup. But yesterday their gaps on the field expanded like an opening wound. The players—and soon after them the ball itself—rolled around more and more slowly. They seemed to be playing uphill.
But there will be more than enough elegies and eulogies for Spain. Let me instead sing the praises of Chile, a team that's been on the upswing for some time now. Their next and final match in the group stage will be against the Netherlands, with the two thus far undefeated teams vying for the top spot in the group. Coincidentally, both teams played Spain in the last World Cup, with Chile losing what was, like yesterday's game, a must-win scenario, 2-0. Both Chile and the Netherlands have already qualified for the knockout rounds, so Monday's game should be a formality—but one of them will likely end up playing Brazil in the next round. But given the way Brazil has been playing, let's not get ahead of ourselves.
Catch up on all the highlights and shout "GOOOOAAAALLL!" at Paris Review.
Tags: Pablo Neruda, Rowan Ricardo Phillips, The Paris Review, World Cup 2014
Posted in Poetry News on Monday, June 23rd, 2014 by Harriet Staff.


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Proceeds from programs and guest room & board generate most of the income needed to cover the Ashram's operating expenses. However, we depend on the generous support of our friends and members for the additional income needed for operating, as well as to help us maintain and improve our infrastructure and expand our facilities.
We hope you will join us for some of the special celebrations, programs and retreats scheduled this season.
Support Your Ashram Generously!
If you would like to make a donation toward the continuing blossoming of the Ashram, please click on one of these links:
- Donations to this fund will be used to replace the roof. It will also be the occasion to do some cost effective renovations on the dining hall itself, which should add more seating.
- Donations to this fund will be used to replace our present guest and teacher apartments with a new building. Under discussion is the idea to expand beyond the present size by creating additional guest spaces, which when rented would cover the cost of maintaining the building.
- Contributions will be used to rebuild the bridge to the island in the lake, which traditionally served to host many special ceremonies and Ashram celebrations. Additional funds may be designated toward a new teacher's apartment.
- Money contributed to the General Fund is used in a variety of ways including for maintenance and beautification of our buildings, grounds and roadways. It will help cover the costs associated with the daily operations and guest services of the Yoga Society such as utility bills, etc.
• The Yoga Society of New York, Inc., is a 501(c)(3) nonprofit
tax-exempt organization. Your gift is tax deductible to the extent permitted by law.


text: all great info! discussing this with ma-in-law. by the way, she is not a cop. She just works for metro. i'll let you guys know if she cites any other references to support the opposite. thanks again for all the info. i just got my holster today, so i'll let you guys know where I open carry.


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Halloween will creep up on you before you know it – time to start planning! Pick a focal point like your fireplace mantle to really do up the spooky decorations. Then carry your theme, in our case, candy corn, throughout all the party details.
L to R: Tiny Prints Kinda Candy Corny invitation, Mantle Décor, Candy Corn Rice Krispie Cupcakes, Candy Corn Punch, Candy Corn Craft, Ribbon Pumpkins


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The epidermal growth factor receptor (EGFR) gene copy number (GCN) has been previously demonstrated to correlate with the clinical outcome of colorectal cancer (CRC) treated with anti-EGFR monoclonal antibodies (mAbs), although it remains controversial. We conducted a systematic review and meta-analysis to assess EGFR GCN as a potential biomarker of survival for patients with advanced CRC receiving treatment with anti-EGFR mAbs.
We systematically identified articles investigating EGFR GCN by fluorescent or chromogenic in situ hybridization or other detection techniques in patients with metastatic CRC treated with panitumumab or cetuximab, (last search: 10 August 2012). Eligible studies had to report on overall survival (OS), progression-free survival (PFS) or time-toprogression (TTP), stratified by EGFR GCN. Summary hazard ratios (HRs) were calculated using random-effects models.
Among 13 identified studies, 10 (776 patients, 302 with increased GCN), 8 (893 patients, 282 with increased GCN) and 3 (149 patients, 66 with increased GCN) were eligible for the OS, PFS and TTP meta-analyses, respectively. Increased EGFR GCN was associated with increased OS (HR = 0.62; 95% CI 0.50–0.77; P<0.001), PFS (HR = 0.65; 95% CI 0.47–0.89; P = 0.008) but not TTP (HR = 0.71; 95% CI 0.44–1.14; P = 0.157). It was also shown that EGFR GCN is independent of other factors such as KRAS status. Among those populations received second-line or higher treatment, increased EGFR GCN was strongly associated with improved survival (for OS, HR = 0.60; 95% CI 0.47–0.75; P<0.001; for PFS, HR = 0.59; 95% CI 0.47–0.75; P<0.001), whereas it did not influence survival in patients that received first-line therapy.
Citation: Jiang Z, Li C, Li F, Wang X (2013) EGFR Gene Copy Number as a Prognostic Marker in Colorectal Cancer Patients Treated with Cetuximab or Panitumumab: A Systematic Review and Meta Analysis. PLoS ONE 8(2): e56205. https://doi.org/10.1371/journal.pone.0056205
Editor: Jian-Xin Gao, Shanghai Jiao Tong University School of Medicine, China
Received: September 18, 2012; Accepted: January 7, 2013; Published: February 18, 2013
Copyright: © 2013 Jiang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by China Postdoctoral Science Foundation (2011M500060) and Heilongjiang Postdoctoral Grant (LRB2010-87864). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
The major prognostic determinant for patients with non-resectable metastic colorectal cancer (CRC) is the response to systemic therapy [1]. During these last years, novel strategies that target the epidermal growth factor receptor (EGFR) have been evaluated in CRC, including monoclonal antibodies (mAbs). These mAbs interfering with the extracellular domain of EGFR, were designed to be used when other treatments failed [2]. Two such mAbs, panitumumab and cetuximab, are active in metastatic colorectal cancer, but the clinical evidence shows that approximately 10% of patients achieve an objective tumor response to anti-EGFR mAbs [2]–[4]. The identification of patients who are likely to be benefited from EGFR-targeted mAbs is increasingly crucial for improving therapeutic strategies, as well as for reducing the financial burden of health care systems [5]. Therefore, the reliable prognostic markers of treatment for selected patients need to be identified.
Several clinical studies have shown that the presence of a KRAS mutation is a significant predictor of resistance to anti-EGFR mAbs [6]–[8]. However, the occurrence of KRAS mutations only accounts for approximately 30% to 40% of nonresponsive patients, suggesting that it may not be the only predictor of cetuximab response and the identification of additional genetic determinants of treatment benefits, still need to be defined. Recently, studies have demonstrated that an increased EGFR gene copy number (GCN), analyzed by the fluorescence in situ hybridization (FISH) technique, could be a promising predictor of anti-EGFR mAbs therapy in metastatic colorectal cancer, patients with low GCN are indeed unlikely to respond to anti-EGFR treatment and have less progression-free time than patients with increased GCN [9]–[12].
Moroni et al. [9] first reported an increased EGFR GCN association with a favorable response to anti-EGFR therapy among KRAS wild-type CRC patients. However, subsequent studies revealed the conclusion remained inconsistent [10], [12]. Studies on the EGFR GCN had shown different trends of the prognosis in CRC, this might be due to a relatively small size and different patient population. Therefore, it is highly necessary to perform a quantitative and systemic study with rigorous methods. Meta-analysis is a powerful means of resolving disparate results. To address the association between variations of EGFR GCN and the survival outcomes of metastatic CRC patients receiving anti-EGFR therapy, a meta-analysis was performed from all eligible studies in this study.
Materials and Methods
Identification and Eligibility of Relevant Studies
We performed a systematic computerized search of the MEDLINE (PubMed) database, EMbase and the Cochrane library (last search: August 10, 2012) to identify all published articles related to the identification of mutations in EGFR pertaining to CRC, using the algorithm: (epidermal growth factor receptor OR EGFR) AND (mutation OR polymorphism OR gene copy number OR GCN OR amplification OR gene status) AND (colorectal cancer OR CRC). Additional studies were identified by a hand search of references of original studies or review articles on this topic. Eligible studies included in the meta-analysis had to meet the following criteria: (a) a cohort colorectal cancer study; (b) hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) comparing overall survival (OS), progression-free survival (PFS) or time-to-progression (TTP) stratified by EGFR gene copy number for patients receiving mono- or combination therapy with either cetuximab or panitumumab were reported or allowed the calculation; and (c) written in English.
Data Extraction
Two investigators independently extracted data and reached a consensus on all of the items. The following information was extracted from each study: first author, years of publication, number of patients screened, ethnicity of study population, gender, proportion of increased GCN, the specific methods of gene copy number determination were recorded, as were the values for GCN cutoff, KRAS status, anti-EGFR mAbs, study design and also for data linking specific mutation to treatment outcome. Also, we categorized studies by line of treatment. When studies were conducted in mixed treatment settings, we operationally defined studies where at least 80% of patients had received previous chemotherapy as 'second-line' studies. Finally, we extracted HRs and their variance for the relevant survival outcomes comparing patients with increased and normal EGFR gene copy number receiving treatment with either cetuximab or panitumumab. The HR is the most appropriate metric for time-to-event outcomes [13], [14]. When the HR and/or its variance were not provided by the eligible studies, we used the methods developed by Parmar et al. [14] to calculate them. When P values were unavailable, the HR was approximated by the ratio of median survivals [15]. Data was extracted by the Engauge Digitizer version 4.1 (free software downloaded from http://sourceforge.net) from survival curves if it was not shown in articles directly, then we estimated the log HR and its variance using the previously reported methods [14], [16]. Two authors performed data extraction independently and discrepancies were resolved by consensus including a third author.
Statistical Analysis
We used the HR and corresponding CI extracted from each study to assess between-study heterogeneity using the Q statistics [17] and inconsistency using the I2 index [18] (I2<25% no heterogeneity; I2 = 25–50% moderate heterogeneity; I2>50% large or extreme heterogeneity). The heterogeneity was considered statistically significant with P<0.10. Summary HRs with their 95% CI were calculated using an inverse variance method. We fitted a random-effects model since between-study heterogeneity was anticipated [19]. Publication bias was investigated by funnel plot, and an asymmetric plot suggested possible publication bias. The funnel plot asymmetry was assessed by Egger's linear regression test [20]. The t test was performed to determine the significance of the asymmetry, and a P value of <0.05 was considered a significant publication bias.
Subgroup analyses were performed to evaluate the effect of ethnicity (East Asian versus white), method of EGFR GCN determination (FISH versus chromogenic in situ hybridization (CISH)), KRAS status (wild versus mixed), the specific EGFR mAbs used (cetuximab versus panitumumab) and line of treatment (≥80% versus <80% second-line) on the prognostic value of EGFR GCN.
Statistical analyses were conducted with Stata (version SE/10; StataCorp, College Station, TX). P values for all comparisons were two-tailed and the statistical significance was defined as P<0.05 for all tests except those for heterogeneity.
Our initial search yielded 76 studies concerning EGFR-targeted treatment in CRC, which were assessed in full text. As indicated in the search flow diagram (Figure 1), 13 studies reported at least one of the outcomes of interest and were finally included in the meta-analysis [10]–[12], [21]–[30]. The search flow diagram is summarized in Figure 1 and the characteristics of eligible studies are summarized in Table 1.
Eight of the studies employed FISH, one employed CISH and two employed both methods, two employed silver in situ hybridization (SISH) and quantitative polymerase chain reaction (qPCR), respectively (Table 1). Gene copy number was scored/assessed according to a different cutoff value, which usually was derived from the receiver operating characteristics (ROC) curve analysis. Twelve studies were retrospective and one was prospective. All eligible studies were small, with sample sizes ranging from 20 to 277 patients (median size = 86 patients, mean size = 92 patients, standard deviation = 67). Overall, the eligible studies reported on 1174 patients, of whom 407 (35%) were characterized as having increased EGFR gene copy number. The frequency increased EGFR gene copy number ranged from 15% to 77%. Eleven of the studies were conducted in European (1058 patients, 338 with increased gene copy number; 32%) whereas two were conducted in East Asian populations (116 patients, 69 with increased gene copy number; 59%). Among all the studies, only three were conducted in wild-type colorectal cancer patients, but two provided data for the outcome in wild-type populations.
Meta-analysis Database
Regarding OS, 10 studies involving 776 patients (302 with increased gene copy number, 39%) contributed data for the meta-analysis. There was no between-study heterogeneity (P = 0.886; I2 = 0.0%) and increased GCN was significantly associated with improved OS among patients treated with anti-EGFR mAbs (HR = 0.62; 95% CI 0.50–0.77; P<0.001) (Figure 2). For PFS, 8 studies involving 893 patients (282 with increased gene copy number; 32%) contributed data for the meta-analysis. Large between-study heterogeneity was observed (P = 0.004; I2 = 66.0%) and increased EGFR GCN was significantly associated with improved PFS (HR = 0.65; 95% CI 0.47–0.89; P = 0.008). Finally, for TTP, only three studies (149 patients, 66 with increased gene copy number, 44%) provided information to be included in the meta-analysis. There was no between-study heterogeneity (P = 0.331; I2 = 9.6%) and we did not find a significant TTP benefit for patients with increased EGFR GCN (HR = 0.71; 95% CI 0.44–1.14; P = 0.157).
Hazard ratios (HR) comparing patients with increased versus not increased EGFR gene copy number are presented. Each study is shown by the point estimate of the HR (square proportional to the weight of each study) and 95% confidence interval for the HR (extending lines); summary HR and their 95% confidence intervals by random-effects calculations are shown by diamonds. Value lower than one indicates that patients with increased EGFR gene copy number have improved survival compared to patients without increase in EGFR gene copy number.
Subgroup Analysis
The results of subgroup analysis are presented in Table 2. Increased EGFR GCN was statistically significantly associated with increased OS and PFS in studies of ≥80% populations received second-line or higher but not <80%, and the positive association was also shown in those populations with KRAS mixed status or wild-type, which suggested EGFR GCN might be an independent prognostic factor. Moreover, positive correlations of increased GCN with OS and PFS were shown in the various ethnicities, anti-EGFR mAbs and detection methods, and no significant difference existed between these subgroups.
Test of Heterogeneity
There was extreme heterogeneity among the 8 studies including PFS (I2 = 66, P = 0.004). Therefore, we performed a meta-regression analysis to evaluate the source of heterogeneity by ethnicity, KRAS status, anti-EGFR mAbs, detection method and line of treatment. However, when we categorized the heterogeneity by these factors, none of these significantly contributed to the observed heterogeneity.
Sensitivity Analysis
Sensitivity analysis was performed both by sequential remove of individual studies and cumulative statistics for all comparisons of all subjects and subgroups. It was shown that with the passage of time and increasing the sample size, the results of OS and PFS become more stable. The pooled HRs were not influenced by any individual study.
Publication Bias
Funnel plots and Egger's test were performed to assess publication bias. The data suggested that there was no evidence of publication bias for the study's primary outcome, OS (Begg's test P = 0.53; Egger's test P = 0.46), PFS (Begg's test P = 0.32; Egger's test P = 0.13), TTP (Begg's test P = 0.60; Egger's test P = 0.85).
In the present study, we collected all available studies and carried out a meta analysis to examine the association of variations of EGFR GCN with prognosis of advanced CRC patients. Ten studies involving 776 patients on OS, eight studies involving 893 patients on PFS and three studies on TTP were critically reviewed. We subgrouped the articles into five groups (ethnicity, KRAS status, anti-EGFR mAbs, detection method and line of treatment). Meta-analysis showed increased EGFR GCN was significantly associated with improved OS and PFS but not TTP. The median OS of patients harboring increased GCN showed 1.61-fold increase, the median PFS showed 1.54-fold increase. A meta-analysis of these studies confirms that increased EGFR GCN is indeed associated with a moderate OS and PFS benefit, from anti-EGFR treatment for metastatic CRC patients. Similarly, EGFR gene copy number has also been evaluated as a potential predictor of response of tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer patients, and a meta analysis has demonstrated an association between increased EGFR copy number, and improved survival outcomes [31]. Recently, Yang et al. performed a meta analysis to differentiate the objective response rate (ORR) between patients with increased EGFR GCN and those with no increased EGFR GCN [32]. They suggested a general trend towards higher ORR in patients with increased EGFR GCN. However, for important prognostic factors as PFS and OS, as the data was relatively incomplete, they only descriptively reviewed published papers and did not perform quantitative synthesis of the studies. In this study, several excellent HR extraction methods were used to calculate the pooled HR quantitatively. The result showed increased EGFR GCN association with improved survival outcomes among anti-EGFR-treated patients. These results imply the EGFR GCN might be not only an effective predictive but also a valuable prognostic marker.
The anti–EGFR monoclonal antibody is effective in prolonging survival in patients with metastatic colorectal cancer after failure of conventional chemotherapy [33], [34]. In our stratified analysis, the increased EGFR GCN was significantly associated with improved OS and PFS in those populations that received second-line or higher but not first-line, which coincided with the strategies in clinical practice of chemotherapy. From a clinical point of view, not only in the US and Europe but also in China, anti-EGFR mAbs were usually used in wild-type KRAS mCRC patients. So, assessing the role of EGFR GCN in patients with wild-type KRAS may be more meaningful. In this study, we found that the prognostic value of EGFR GCN on survival appears to not be related to KRAS status, which suggested EGFR GCN might be an independent prognostic biomarker. The significant association between survival with EGFR GCN, revealed tumor growth is probably mainly driven by the EGFR pathway and this biological characteristic is evoked by an increase in EGFR copy number.
EGFR is a transmembrane tyrosine kinase receptor that, on ligand binding, triggers two main signaling pathways, the RAS-RAF-MAPK axis, which is mainly involved in cell proliferation, and the PI3K-PTEN-AKT pathway, which is mainly involved in cell survival and motility [35]. The anti-EGFR mAbs have been proven to be effective in metastatic colorectal cancer. The molecular mechanisms underlying the clinical response to this drug remain unknown. Genetic alterations in EGFR-related signaling pathways may have an effect on response to this targeted therapy, which may be due to the constitutive activation of the downstream genes of the EGFR signaling pathway such as KRAS, BRAF, or PIK3C2A, or to the loss of a tumor suppressor gene such as PTEN. Until now, the most acceptable marker, as a predictive and prognostic factor, was the status of KRAS. However, KRAS was not the only predictor of the cetuximab response. The present study was aimed at assessing the prognostic role of EGFR GCN, in terms of clinical outcome, in patients treated with anti-EGFR mAbs. EGFR GCN detection also appears to be relevant to positively identify responders. Variations of GCN, reflect the many different routes taken by individual tumors to disrupt/escape mechanisms governing normal cellular behavior. In most solid tumors, including CRC, the best characterized mechanisms underlying increased EGFR GCN are gene amplification and chromosome 7 polysomy [9], [10], [12], [36].
Current obstacles for a future clinical application of EGFR GCN are mainly concentrated on the following two aspects: detection methods and difficult technical reproducibility. FISH technique has been used in most previous studies, but the FISH results are challenging to interpret and the lack of standardization of analytical methods and scoring systems may partly explain why the EGFR GCN evaluation has not been incorporated into clinical practice yet [37]. When looking at the different cutoff values in the literature, we found reproducibility remains a large obstacle for its practical usefulness and an international consensus on the definition of cutoff points is needed. Sartore-Bianchi et al. also found that molecule diagnosis of EGFR GCN by FISH among five highly experienced pathology centers varied largely, a detailed scoring system and comprehensive training programmes are necessary [38]. Although different cutoff points have been applied, 95% CIs around sensitivity and specificity yielded by each cutoff point were similar, thus indicating that results from these studies are consistent. In the present study, we analyzed the influence of GCN detection method on survival and did not found any discrepancies.
There are several limitations kept in consideration in this meta-analysis. First, most of the studies were not conclusive because they evaluated limited patient series that were nonhomogeneously treated. Second, relatively small sample sizes included in East Asians may also influence the results, and further studies are necessary to detect the potential role of GCN. Third, primarily the unavailability of individual patient data that would allow correction for potential confounding factors such as age, gender, or additional genetic aberrations. Finally, different detection methods used in the studies included in the analysis may have different quality control issues.
In conclusion, our meta-analysis provides evidence that EGFR gene copy number is a prognostic marker for survival among patients receiving anti-EGFR mAbs for advanced colorectal cancer. Furthermore, according to our results, the prognostic ability of EGFR gene copy number appears to be significantly stronger among those populations that received second-line or higher treatment.
Author Contributions
Contributed some part of additional potentially eligible literature: FL. Conceived and designed the experiments: XW. Performed the experiments: ZJ CL FL. Analyzed the data: ZJ CL. Contributed reagents/materials/analysis tools: ZJ CL FL. Wrote the paper: ZJ CL.
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text:
Recently, I tried CJ CQ + BRHG as a substitute for CJ CIAB + SS FHG and had very nice results. My combo:
CJ CCCC lite + CJ CQ + BRHG
There was only a tiny bit of frizz when it dried, so I scrunched in a little CJ aloe fix gel as a sealant, and then scrunched that out once it dried. I had very nice results!
I don't care for CJ CQ in low dews - too much protein, I suspect - but I was surprised how well it worked in high dews.
Next time, I want to try this combo without the BRHG (since I just used a dab anyway), and see how my hair holds up. The added aloe fix gel to seal might suffice for the extra hold I need.
I'd also like to try this again with regular CCCC instead of CCCC lite, and see if there's a difference.
Anyone else using (and liking) CJ CQ in high dews? If so, how are you using it?


text:
I'm a big fan of the sandtrooper weapons and after scratchbuilding a DLT-19 (MG34) for my custom mando (see pics of it here http://www.thedentedhelmet.com/showthread.php?t=33826 ) I thought I would take on the task of making the Lewis gun.
I couldn't find any useful tutorials but I found this pic on TK-409's website
After seeing that I just whipped out some paper and a ruler and started making my own templates..
Then transfered the templates onto a piece of 3/4" thick wood twice...
After cutting them out, I glued the two pieces together then put screws in to hold it.
Then I started on the barrel. I used a piece of 3" pvc, 2" pvc, and a 3" to 2" reducer. I put those pieces together then put a piece of flex pipe (not sure what it's really called) over part of the 3" pipe...This is what I have so far!
Let me know what you think.


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About Ocean City
Ocean City, NJ is recognized as one of the east coast's most vibrant and family oriented beach destinations. Watch the Atlantic crash into a coast strewn with seafood shacks, surf shops, casual and fine dining venues, unique boutiques and more. With your vacation home just steps away from the ocean, you will have no trouble locating ideal surfing and swimming spots. Ocean City's 3 mile boardwalk is truly a symbol of the city's vitality, and is filled with an endless stream of restaurants and shops. Enjoy one of the many classic beach amusement rides along the boardwalk, including Gillian's Wonderland Pier, a 140-foot Ferris Wheel that can be seen from miles away. The ride offers breath-taking panoramic views of the beach, ocean, and city.
Here are a few additional suggestions for your trip:
- Stroll the downtown: Spend some time walking along Asbury Avenue in the center of downtown Ocean City and enjoy great shopping in the unique boutiques and specialty shops.
- Take a Ghost Tour: Take a walking tour of Ocean City and listen to old folklore and tales while getting a glimpse at some of the most historic buildings around. These candle-lit tours are offered in the evenings between June and October.
- Play a hand of cards: Head to Atlantic City, just a 15 minute drive from Ocean City, and enjoy lively dining, casino, and entertainment venues.
- Learn to surf: The gentle surf of Ocean City and the great surf schools with patient teachers can help first timers get out into the waves.
- Join a dinner cruise: Watch the sunset and enjoy a glass of champagne and some live entertainment while dining on the deck of a luxury sailboat.
- Hike the trails: Outdoor enthusiasts come from all along the east coast to experience hiking and camping in Ocean City, NJ.
Invite your friends and family to join you in a luxury summer rental along the coast. It's easy to find the perfect condo rental within a few steps of the beach that also offers access to downtown shopping and nightlife. Luckily, vacation rental opportunities are available in Ocean City during every season of the year and offer more space and better amenities than hotels in the area. While you're here, you may also want to explore the Pine Barrens or the historic city of Philadelphia, both just a short drive away.


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Nye to take part in creation debate
LOUISVILLE, Ky. (AP) — Bill Nye "The Science Guy" is set to visit Kentucky to debate evolution and biblical creation with the founder of the Creation Museum.
Ken Ham wrote on his Facebook page Thursday that he will square off Feb. 4 with Nye, the former host of a popular science TV show for youths.
The event is likely to attract plenty of attention in scientific and faith circles, as Nye is a high-profile advocate of science education and Ham is a respected leader among Christians who believe the Bible's origin story is a factual account of the Earth's beginnings. Ham had been hoping to attract the star of TV's "Bill Nye The Science Guy" to the northern Kentucky museum after Nye said in an online video last year that teaching creationism was bad for children. The video was viewed nearly 6 million times on YouTube.
"Having the opportunity to hold a cordial but spirited debate with such a well-known personality who is admired by so many young people will help bring the creation-evolution issue to the attention of many more people, including youngsters," Ham said in a release Thursday.
The Creation Museum has been lauded by supporters and prodded by scientists for exhibits that assert the Earth was created in a few days about 6,000 years ago. It also has displays with dinosaurs and humans living alongside each other, in contradiction to scientific findings that the two species were separated by more than 60 million years.
Nye said in an Associated Press interview in September that steering children away from evolution and teaching creationism would hurt scientific advances. Science has demonstrated that the Earth is billions of years old, and "if that conflicts with your beliefs, I strongly feel you should question your beliefs," he told the AP.
Nye, who is executive director of the Planetary Society, said in that interview that he would be willing to travel to Kentucky and debate Ham if the museum paid his travel expenses.
The event will be titled "Is Creation A Viable Model of Origins?" Tickets to the evening event at the museum's Legacy Hall will be $25.