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Ca2+ influx via the platelet P2X1 ion channel contributes to collagen-induced platelet activation.
; Oury, Cécile ; et al
in Haematologica (2002), 87Detailed reference viewed: 16 (1 ULg)
Pre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.
Baron, Frédéric ; ; Schaaf-Lafontaine, Nicole et al
in Haematologica (2002), 87(1), 78-88
BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood ... [more ▼]
BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS: Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2 x 10(6), 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140). RESULTS: An average of 100%, 100% and 84% of the scheduled dose could be administered in DLI 1, 2 and 3, respectively. Although the study group was at very high risk of GVHD, the actuarial incidence of grade II-IV acute GVHD was 28% (13% for HLA-identical siblings) with only 1 patient developing grade III-IV GVHD (after DLI). The actuarial 2-year probability of extensive chronic GVHD was similarly low (13% for all patients and 0% for HLA-identical siblings). Individual cases as well as a 30% relapse rate (0% for standard-risk patients versus 55% for high-risk patients) indicated preservation of the GVL effect. INTERPRETATION AND CONCLUSIONS: We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to prove that it preserves the GVL effect fully. [less ▲]Detailed reference viewed: 31 (5 ULg)
Combination of nonmyeloablative stem cell transplantation and Imatinib in accelerated phase CML.
Baron, Frédéric ; Frere, Pascale ; Herens, Christian et al
in Haematologica (2002), 87(12), 43Detailed reference viewed: 10 (0 ULg)
Reticulocyte transferrin receptor (TfR) expression and contribution to soluble TfR levels.
R'Zik, Samir ; ; Beguin, Yves
in Haematologica (2001), 86(3), 244-51
BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of ... [more ▼]
BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present in serum in proportion to the mass of cellular TfR. Although sTfR shedding by reticulocytes and erythroblasts has been demonstrated in vitro, the contribution of reticulocyte TfR to serum sTfR has never been evaluated in vivo. DESIGN AND METHODS: We measured directly the total number of reticulocyte TfR in normal rats of different age and iron status, as well as in animals experiencing various conditions and treatments aimed at altering erythropoietic activity and iron status, including rHuEpo therapy, hemolytic anemia, phlebotomies, hypertransfusions, thiamphenicol-induced red cell aplasia or inflammation. In addition, we examined the impact of repeated hypertransfusions with normal, reticulocyte-poor and reticulocyte-rich blood on serum sTfR levels. RESULTS: The number of TfR molecules per reticulocyte was around 50,000 in young rats but was around 100,000 in older animals. These values remained constant in most conditions and in particular were not influenced by iron supplementation or iron overload. However, functional iron deficiency as well as rHuEpo therapy resulted in increased reticulocyte TfR expression. In addition, TfR numbers in reticulocytes were elevated in the early phase of recovery after acute hemolysis or red cell aplasia but normalized soon after. Hypertransfusion experiments clearly demonstrated that reticulocytes can contribute substantially to sTfR levels in vivo. INTERPRETATION AND CONCLUSIONS: TfR numbers are regulated in vivo by the same factors as in vitro, in particular iron deficiency and erythropoietin stimulation. Circulating reticulocytes contribute significantly to serum sTfR levels. [less ▲]Detailed reference viewed: 86 (1 ULg)
Administration of erythopoietin and granulocyte colony-stimulating factor in donor/recipient pairs to collect peripheral blood progenitor cells (PBPC) and red blood cell units for use in the recipient after allogeneic PBPC transplantation.
Sautois, Brieuc ; Baudoux, Etienne ; Salmon, Jean et al
in Haematologica (2001), 86(11), 1209-18
BACKGROUND AND OBJECTIVES: It may be useful to reduce the exposure of transplant recipients to homologous blood. This may be achieved by procuring donor-derived red blood cell (RBC) units, collecting more ... [more ▼]
BACKGROUND AND OBJECTIVES: It may be useful to reduce the exposure of transplant recipients to homologous blood. This may be achieved by procuring donor-derived red blood cell (RBC) units, collecting more peripheral blood progenitor cells (PBPC) with a combination of granulocyte colony-stimulating factor (G-CSF) + recombinant human erythropoietin (rHuEpo) and by administering rHuEpo post-transplantation. DESIGN AND METHODS: Eight ABO-compatible donors were treated with rHuEpo and intravenous iron to collect 12 RBC units for use in their recipients. PBPC were collected after mobilization with rHuEpo and G-CSF in the same donors. The recipients received G-CSF and rHuEpo post-transplantation. A control group of 10 donor/recipient pairs received G-CSF alone for PBPC mobilization and after the transplantation. RESULTS: Eighty-six out of 91 planned RBC units were collected in the donors without significant decrease in hematocrit because of a 4-fold increase in RBC production despite functional iron deficiency. After 2 leukaphereses, the cumulative yields of NC and CFU-GM were lower in the study group while those of BFU-E, CFU-Mix and CD34+ cells were similar. However, erythroid recovery was significantly accelerated in the study group. INTERPRETATION AND CONCLUSIONS: Collection of 12 RBC units within 6 weeks is feasible with rHuEpo and intravenous iron; this strategy allows a dramatic reduction in recipient exposure to homologous blood; rHuEpo has no synergistic effect with G-CSF for mobilization of PBPC in normal donors and may even be deleterious; and rHuEpo in the recipient may enhance erythroid engraftment. [less ▲]Detailed reference viewed: 65 (4 ULg)
Whole-body positron emission tomography using 18F-fluorodeoxyglucose compared to standard procedures for staging patients with Hodgkin's disease.
Jerusalem, Guy ; Beguin, Yves ; Fassotte, Marie-France et al
in Haematologica (2001), 86(3), 266-73
BACKGROUND AND OBJECTIVES: Accurate staging is essential in order to determine appropriate treatment in Hodgkin's disease (HD). (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) offers ... [more ▼]
BACKGROUND AND OBJECTIVES: Accurate staging is essential in order to determine appropriate treatment in Hodgkin's disease (HD). (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) offers the advantage of metabolic imaging that is largely independent of morphologic criteria. In the present study we evaluated the role of (18)F-FDG PET compared to routine procedures for the staging of patients with HD. DESIGN AND METHODS: Thirty-three patients with HD underwent standard staging procedures (clinical examination, laboratory screening, chest X-ray, computed tomography (CT) of the chest and abdomen and bilateral bone marrow biopsies) and a whole-body (18)F-FDG PET study. In clinical examination, an isolated lymph node > 1 cm or multiple lymph nodes > or = 1 cm in size were considered abnormal. Positive findings at both clinical examination or CT and (18)F-FDG PET were regarded as actual locations of disease. Negative findings with both methods were regarded as true negative (no involvement by HD). In cases of discrepancy, response to treatment and follow-up data were used to assess the overall accuracy of the patient's original evaluation. RESULTS: Completely concordant results in lymph node staging were observed in 20 patients. The two staging procedures indicated complementary information in 1 patient. Conventional staging indicated more pathologic lymph node areas in 6 patients (at least 1 false positive). (18)F-FDG PET showed more sites in 6 patients. The sensitivity of (18)F-FDG PET in detecting all known pathologic lymph nodes was 83% for peripheral lymph nodes, 91% for thoracic lymph nodes and 75% for abdominal and pelvic lymph nodes. Conventional staging procedures and (18)F-FDG PET indicated the same tumor stage in 26 patients. Based on (18)F-FDG PET, downstaging was suggested in 4 patients, including a biopsy-proven case. However in 1 of these cases this was incorrect. (18)F-FDG PET suggested upstaging in 3 patients. Based on conventional staging or (18)F-FDG PET the same treatment strategy was defined in 32 patients. In one patient (18)F-FDG PET downstaged disease extension (stage IIIA-->IIA) that would have suggested radiotherapy as a possible treatment option. INTERPRETATION AND CONCLUSIONS: (18)F-FDG PET provides an easy and efficient whole-body method for the evaluation of patients with HD. (18)F-FDG PET never missed tumor masses >1 cm. (18)F-FDG PET detected additional sites of disease not seen by conventional procedures and identified absence of disease in some sites suspected to be involved. However, in our patients this did not translate into changes in treatment strategy. [less ▲]Detailed reference viewed: 41 (1 ULg)
Treatment of leukemia relapse after allogeneic hematopoietic stem cell transplantation by donor lymphocyte infusion and STI-571.
Baron, Frédéric ; Frere, Pascale ; Fillet, Georges et al
in Haematologica (2001), 86(9), 993-4Detailed reference viewed: 23 (0 ULg)
Differential Expression of Cellular Prion Protein on Human Blood and Tonsil Lymphocytes
Antoine, Nadine ; ; Coumans, Bernard et al
in Haematologica (2000), 85(5), 475-80
BACKGROUND AND OBJECTIVE: The expression of cellular prion protein (PrPc) on the surface of peripheral lymphocytes has been previously reported, but little is known about its expression on lymphoid cells ... [more ▼]
BACKGROUND AND OBJECTIVE: The expression of cellular prion protein (PrPc) on the surface of peripheral lymphocytes has been previously reported, but little is known about its expression on lymphoid cells from secondary lymph organs. In this report, we compare the surface expression of PrPc on human blood lymphocytes and tonsil lymphocytes. DESIGN AND METHODS: This analysis was performed by cytometry on live lymphocytes isolated from healthy donors or from the tonsils of adults or children. RESULTS: Human peripheral lymphocytes and tonsillar lymphoid cells, but not erythrocytes or granulocytes, express PrPc at their surfaces. Interestingly, we found significantly less PrPc on freshly isolated tonsil lymphocytes, both B and T, than on blood cells. Although tonsil cells bear less PrPc than circulating blood lymphocytes, they are able to express high quantities of PrPc on their surface when placed in culture. However, contrary to previous results, mitogen stimulation does not affect this expression on B- or T-cells. INTERPRETATION AND CONCLUSIONS: We suggest that the PrPc expression by lymphocytes may be modified by interactions occurring during intratissular migration or during cell-to-cell contacts. Whether PrPc plays a role in intracellular communication at this location, as it does in the nervous system, remains an open question. [less ▲]Detailed reference viewed: 37 (4 ULg)
ADP-induced activation of the extracellular-regulated kinase/mitogen-activated protein kinase pathway via the ionotropic P2X1 receptor in platelets.
Oury, Cécile ; ; et al
in Haematologica (2000), 85Detailed reference viewed: 7 (1 ULg)
Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ; Beguin, Yves ; Fassotte, Marie-France et al
in Haematologica (2000), 85(6), 613-8
BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]
BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]Detailed reference viewed: 42 (2 ULg)
The belgian experience in unrelated donor bone marrow transplantation: identification of center experience as an important prognostic factor.
Dresse, Marie-Françoise ; ; et al
in Haematologica (1999), 84(7), 637-42
BACKGROUND AND OBJECTIVE: We reviewed all unrelated donor bone marrow transplants (UDBMT) performed in Belgium up to December 1995 to identify prognostic factors for relapse, transplant-related mortality ... [more ▼]
BACKGROUND AND OBJECTIVE: We reviewed all unrelated donor bone marrow transplants (UDBMT) performed in Belgium up to December 1995 to identify prognostic factors for relapse, transplant-related mortality and survival. DESIGN AND METHODS: A total of 163 UDBMT were performed in 92 males and 71 females aged 1-55 (median 26) years. Patients were transplanted for ALL (n=35), AML (n=34), CML (n=51), other myeloid malignancies (n=14), SAA (n=21) or miscellaneous other diseases (n=8). Most patients had advanced disease; a few patients were in CR1 (n=10) or early chronic phase (CP) of CML (n=5). RESULTS: Overall survival at 5 yrs was 17% (95% confidence interval: 8-32%), but survival was significantly better for patients with non-malignant disorders (55% at 4 yrs). The relapse rate +/-SE was projected to be 40 (28-54)% at 5 yrs, 36 (20-56)% for standard-risk and 68 (43-85)% for high-risk malignancies (p=0.0029). There was no relapse in CML patients transplanted in 1st CP compared to 68% at 4 yrs with more advanced CML (p=0.0033). Grade II-IV acute graft-versus-host disease (aGVHD) occurred in 55% by day 100 and was strongly modulated by age, ranging from 41% in <20-yr-old to 80% in >40-yr-old patients (p=0. 0021). Transplant-related mortality (TRM) was projected to be 72 (52-87)% at 5 yrs including 2 very late deaths from lung fibrosis and secondary cancer. Main causes of death were original disease in 27, secondary malignancy in 2, GVHD in 28, interstitial pneumonia in 21, other infections in 19, and miscellaneous toxic causes in 21 patients. In multivariate analysis, the relapse rate was strongly dependent on the disease status (p=0.0029), TRM being significantly worse with older age (p=0.0049), and overall survival being significantly worse in more advanced disease (p=0.0006), after a second transplant (p=0.0166), in centers of smaller size (p=0.0316) and in older patients (NS). INTERPRETATION AND CONCLUSIONS: Although results have improved somewhat in recent years, UDBMT remains a procedure with a high TRM. UDBMT should be performed in patients with less advanced diseases and in centers with more experience, particularly in the treatment of adult patients. [less ▲]Detailed reference viewed: 85 (6 ULg)
Erythropoietin and platelet production.
Beguin, Yves
in Haematologica (1999), 84(6), 541-7
BACKGROUND AND OBJECTIVE: Erythropoietin (Epo) is the primary growth factor for the red cell lineage but treatment with recombinant human Epo (rHuEpo) has been shown to increase platelet counts. In ... [more ▼]
BACKGROUND AND OBJECTIVE: Erythropoietin (Epo) is the primary growth factor for the red cell lineage but treatment with recombinant human Epo (rHuEpo) has been shown to increase platelet counts. In several animal species treatment with rHuEpo stimulated platelet production, but platelet counts tended to normalize after 1-2 weeks and large, chronic doses even caused thrombocytopenia. This paper aims to review the evidence about the effects of Epo on megakaryopoiesis. INFORMATION SOURCES: I examined the literature published in journals covered by Medline(R)a concerning the effects of Epo, hypoxia and iron deficiency on megakaryopoiesis and platelets. The reference list of each article was reviewed to try to identify further contributions. STATE OF THE ART: In vivo data have shown that moderate Epo stimulation, i.e. that produced by standard doses of rHuEpo, short-term hypoxia or moderate iron deficiency, causes a moderate elevation of platelet counts, whereas intense Epo stimulation, as produced by high doses of rHuEpo, prolonged hypoxia or severe iron deficiency, causes some degree of thrombocytopenia. In the latter case, there appears to be a diphasic response to Epo, the initial positive response (a stimulation of platelet production) being followed by thrombocytopenia. Contrarily to the thrombocytopenia due to increased platelet destruction induced by other growth factors, Epo-induced thrombocytopenia is the result of an inhibition of platelet production. CONCLUSION AND PERSPECTIVE: Stem-cell competition between erythroid and platelet precursors appears to be the cause of these phenomena in situations of prolonged, intense stimulation by Epo. In vitro data support the existence of a common erythrocytic and megakaryocytic precursor. It remains to be determined whether these effects of rHuEpo are a result of the dose itself or of the magnitude of the erythropoietic effect of that dose. It is not known whether a lower dose given in a patient with decreased marrow function would bring about the same biological effects as those induced by high doses of rHuEpo in the presence of a normal marrow function. Caution should be exercised before using high doses of hematopoietic growth factors. [less ▲]Detailed reference viewed: 30 (0 ULg)
Peripheral blood progenitor cell collections in cancer patients: analysis of factors affecting the yields.
Sautois, Brieuc ; ; Baudoux, Etienne et al
in Haematologica (1999), 84(4), 342-9
BACKGROUND AND OBJECTIVE: Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies. We sought to identify ... [more ▼]
BACKGROUND AND OBJECTIVE: Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies. We sought to identify parameters that could predict the yield of PBPC after mobilization with chemotherapy (CT) with or without granulocyte colony-stimulating factor (G-CSF) in cancer patients. DESIGN AND METHODS: One hundred and fifty patients underwent 627 PBPC collections during the recovery phase following CT with (n = 469) or without (n = 142) G-CSF. Hemogram, CFC-assays and CD34+ cell count were performed on peripheral blood and leukaphereses products. After log transformation of the data, differences between groups were assessed with the unpaired t-test or one-way analysis of variance. RESULTS: Seventeen and two patients required 2 and 3 mobilization cycles respectively to reach our target of 15x10(4) CFU-GM/kg. In patients with lymphoma but not in those with leukemia, the yields of both CFU-GM and CD34+ cells/kg were dramatically increased when G-CSF was added to CT for mobilization. In collections primed with CT and G-CSF, better yields were obtained in patients with breast cancer or small-cell lung carcinoma (SCLC) as opposed to other solid tumors and leukemia. Among potential predictive factors of CT- and G-CSF-primed harvests, we found that the CD34+ cell count in peripheral blood (PB) was strongly correlated with both the CFU-GM and CD34+ cell yields. Except in leukemia patients, more than 1x10(6) CD34+ cells/kg were harvested when the CD34+ cell count in blood was above 20x10(6)/L. Similarly, better results were obtained in collections performed when the percentage of myeloid progenitors in blood on the day of apheresis was above 5 % or when the leukocyte count in blood was above 5x10(9)/L. INTERPRETATION AND CONCLUSIONS: A diagnosis of breast cancer or SCLC, a leukocyte count in PB of more than 5x10(9)/L, more than 5% myeloid progenitors or more than 20x10(6) CD34+ cells/L in PB were associated with higher yields of PBPC in collections mobilized with CT+G-CSF. [less ▲]Detailed reference viewed: 80 (10 ULg)
Influence of marrow erythropoietic activity on serum erythropoietin levels after autologous hematopoietic stem cell transplantation.
Beguin, Yves ; Baron, Frédéric ; Fillet, Georges
in Haematologica (1998), 83(12), 1076-81
BACKGROUND AND OBJECTIVE: Serum erythropoietin (sEpo) concentration depends primarily on the rate of renal production in response to hypoxia. However, sEpo levels increase inappropriately after ... [more ▼]
BACKGROUND AND OBJECTIVE: Serum erythropoietin (sEpo) concentration depends primarily on the rate of renal production in response to hypoxia. However, sEpo levels increase inappropriately after conditioning for autologous stem cell transplantation (ASCT) before progressively returning to adequate levels. We investigated the possible influence of erythropoietic activity on these observations. DESIGN AND METHODS: Forty patients undergoing an ASCT, 8 with bone marrow (BMT) and 32 with peripheral blood stem cells (PBSC), were separated into 3 groups. Group 1 was formed of the 8 BMT patients (median time to 1% reticulocytes: 39 days), group 2 of 16 PBSC patients with relatively slow erythroid engraftment (> or = 15 days to 1% reticulocytes, median 19 days) and group 3 of 16 PBSC patients with prompt erythroid recovery (< 15 days to 1% reticulocytes, median 13 days). Marrow erythroid activity was assessed by serum transferrin receptor levels (sTfR). Serum Epo (sEpo) levels were expressed in relation to the degree of anemia as observed/predicted (O/P) ratios of (O/P) log (sEpo). RESULTS: Serum sTfR levels decreased by more than 50% in all 3 groups after conditioning, reaching their nadir on day 7. Nadir values doubled by day 28 in group 3, day 60 in group 2, but not within 100 days in group 1. O/P sEpo ratios increased inappropriately in all 3 groups after conditioning but then declined at very differing speeds in the 3 groups. In group 1, ratios remained above 1.10 through to day 28 and above 1.00 through to day 42, before leveling off at around 1.00 thereafter. In group 2, ratios remained above 1.00 through to day 14, than decreased to a minimum of 0.89 by day 42 before returning to 1.00 by day 100. In group 3, ratios decreased to 0.84 by day 21 and remained below 0.90 thereafter. INTERPRETATION AND CONCLUSIONS: We conclude that sEpo levels are not only influenced by tissue oxygenation but also depend on the mass of erythroid precursors in the bone marrow. This may be the main explanation for the observed changes in sEpo levels during ASCT. [less ▲]Detailed reference viewed: 14 (3 ULg)
The veno-occlusive disease of the liver.
Baron, Frédéric ; Deprez, Manuel ; Beguin, Yves
in Haematologica (1997), 82(6), 718-25
BACKGROUND AND OBJECTIVE: The veno-occlusive disease of the liver (VOD) is a disorder caused by the non-thrombotic occlusion of the central veins of hepatic lobules. The clinical features are similar to ... [more ▼]
BACKGROUND AND OBJECTIVE: The veno-occlusive disease of the liver (VOD) is a disorder caused by the non-thrombotic occlusion of the central veins of hepatic lobules. The clinical features are similar to those of intrahepatic portal hypertension (unexplained weight gain, ascites, painful hepatomegaly, jaundice). In the past, this disease was rather infrequent and was linked to the absorption of toxic agents, liver irradiation or chemotherapy. However, the intensification of treatment protocols before hematopoietic stem cell transplants has considerably increased its incidence. The strategies used for its prevention and treatment remain limited in efficacy. The present review was undertaken in order to assess progress in the diagnosis and management of this severe complication in stem cell transplantation. INFORMATION SOURCES: The method used for preparing this review was an examination of 250 relevant articles or abstracts published in journals covered by Medline. STATE OF ART: Despite the progress made toward the understanding of its physiopathology and the identification of its risk factors, VOD is still one of the leading causes of morbidity and mortality during the first two months post-BMT, and therefore often constitutes a limitation for the further increment of the dose of antineoplastic drugs. This may be explained by the difficulty in making an early diagnosis of this problem, at a time when therapeutic intervention may be more effective, and, on the other hand, the lack of a well-established prevention and treatment approach for patients with VOD. PERSPECTIVES AND CONCLUSIONS: New diagnostic procedures, such as laparoscopic liver biopsy, and new therapeutic approaches, such as transjugular intrahepatic portosystemic shunting (TIPS) or defibrotide, are now being evaluated. However, additional studies will be needed to determine the most appropriate therapy for each VOD patient depending on the severity of the disease. [less ▲]Detailed reference viewed: 19 (4 ULg)
Prediction of response to recombinant human erythropoietin (rHuEpo) in anemia of malignancy.
; ; et al
in Haematologica (1996), 81(5), 434-41
BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very ... [more ▼]
BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very useful. MATERIALS AND METHODS: We retrospectively reviewed the clinical records of 58 patients with refractory anemia associated with various malignant disorders who had been treated with subcutaneous rHuEpo. The starting rHuEpo dose was 375 U/kg/week for 4 weeks, and was increased to 750 U/kg/week for another 4 weeks if no response was observed. Response was defined as a Hb increase > or = 2 g/dL with no need for blood transfusion. We examined the value of various laboratory parameters (baseline levels, 2-week and 4-week changes) as predictors of response. Endogenous erythropoietin production was evaluated by its serum level and erythroid activity was assessed through reticulocyte count and circulating transferrin receptor. RESULTS: Forty-eight individuals were evaluable, 58% of whom responded to rHuEpo within 8 weeks. Multiple regression analysis showed that 53% of the variation in the 8-week Hb concentration was explained by variations in baseline serum erythropoietin and the 2-week change in serum transferrin receptor (p < 0.001). Based on these two parameters, response prediction in individual patients would have resulted in a sensitivity of 96%, a specificity of 79% and an overall accuracy of 88%. In addition, 58% of the variation in the 8-week Hb was explained by variations in the 4-week changes in Hb and reticulocyte count (p < 0.001). Utilizing these latter parameters and baseline serum erythropoietin, response prediction in individual patients would have resulted in a sensitivity of 92%, a specificity of 82% and an overall accuracy of 88%. CONCLUSIONS: This retrospective analysis suggests that response to rHuEpo can be reasonably predicted by pretreatment serum erythropoietin together with early changes in simple laboratory parameters. [less ▲]Detailed reference viewed: 16 (0 ULg)
Pure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin.
; ; Beguin, Yves et al
in Haematologica (1994), 79(5), 456-9
We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia ... [more ▼]
We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia. Corticosteroid treatment was ineffective. Four months after transplantation rHuEpo was administered subcutaneously at a dose of 150 U/Kg per day, five days a week for 8 weeks. Treatment induced an erythropoietic response and corrected anemia. Response was maintained following discontinuation of rHuEpo. This study and previous reports indicate that high doses of rHuEpo given over a short time can resolve PRCA following autologous or allogeneic stem cell transplantation. [less ▲]Detailed reference viewed: 24 (0 ULg)
The soluble transferrin receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis.
Beguin, Yves
in Haematologica (1992), 77(1), 1-10
Iron transport in plasma is carried out by transferrin, which donates iron to cells through interaction with a specific membrane receptor. In this review, we summarize the current knowledge on the ... [more ▼]
Iron transport in plasma is carried out by transferrin, which donates iron to cells through interaction with a specific membrane receptor. In this review, we summarize the current knowledge on the structure, intracellular cycle, distribution, and regulation of the tissue transferrin receptor. A soluble form of the transferrin receptor has been identified in animal and human serum. We review the molecular form and origin of the soluble receptor, its dosage in normal serum and its relationship with erythropoiesis, iron status, and cancer. Lastly, we discuss the clinical usefulness of the soluble transferrin receptor for the quantitative determination of marrow erythropoietic activity. [less ▲]Detailed reference viewed: 23 (2 ULg)
Evaluation of erythroid marrow response to recombinant human erythropoietin in patients with cancer anaemia.
; Beguin, Yves ; et al
in Haematologica (1992), 77(6), 494-501
BACKGROUND. Anaemia is a frequent finding in patients with cancer and may be due to different causes, including blunted erythropoietin production. MATERIALS AND METHODS. In a pilot study, we administered ... [more ▼]
BACKGROUND. Anaemia is a frequent finding in patients with cancer and may be due to different causes, including blunted erythropoietin production. MATERIALS AND METHODS. In a pilot study, we administered recombinant human erythropoietin (rHuEPO) to twelve patients with solid tumours and secondary anaemia. rHuEPO was given subcutaneously 5 d per week at escalating doses (75 to 150 U/kg per day): the aim of treatment was a Hb level > or = 10 g/dl without blood transfusion. We evaluated endogenous EPO production through serum EPO levels and erythroid marrow activity by means of serum transferrin receptor (TfR). RESULTS. Six out of 12 subjects had defective endogenous EPO production. All patients but two responded to treatment with steady increases in Hb levels above 10 g/dl, and the median dose of rHuEPO required for correction of anaemia was 75 U/kg. Response was associated with an early increase in serum TfR. Six patients developed functional iron deficiency and required iron supplementation to obtain response. Treatment improved functional ability in 4/10 responders. CONCLUSIONS. Subcutaneous rHuEPO can stimulate erythroid marrow activity in cancer anaemia, even in patients with advanced disease, and marrow response can be adequately monitored by serum TfR. Functional iron deficiency as a cause of nonresponse to rHuEPO is frequent in these patients and may require parenteral iron administration. Although erythropoietin can improve the anaemia of cancer, the decision to treat should be individualised for each patient, looking more at the quality of life and cost-effectiveness than at cosmetic increases in the haemoglobin level. [less ▲]Detailed reference viewed: 21 (2 ULg)


text:
Meeting:Ambassadors 2009-11-2
From FedoraProject
(Difference between revisions)
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|Line 42:
Summary is available here:
Summary is available here:
== Next Meeting ==
== Next Meeting ==
Latest revision as of 04:14, 5 November 2009
[edit] Fedora Ambassadors Meeting Minutes 2009-11-3 - North America
[edit] Meeting Time
( 2009-11-3 21:00 Eastern )
- #fedora-meeting on freenode
[edit] Participants
This week's Ambassadors Meeting will be lead by Scott McBrien.
- The participants can be extracted from the logs by anyone who really wants to see them.
[edit] Meeting Protocol
- Please follow Meeting Protocol
[edit] Agenda
- Roll Call
- Announcements
- Events
- SCaLE_8x_Event head start (Lcafiero)
- Budget Review
- Handling monetary contributions?
- Task List Review
- Window Clings - Scott McBrien
- Open floor
- FreeMedia program in NA/Suggested change to the program
[edit] Transcript
Transcript can be found here: http://meetbot.fedoraproject.org/fedora-meeting/2009-11-04/fedora-meeting.2009-11-04-02.00.log.html
[edit] Summary
Summary is available here: http://meetbot.fedoraproject.org/fedora-meeting/2009-11-04/fedora-meeting.2009-11-04-02.00.html
[edit] Next Meeting
- See Ambassadors Meetings for the next meeting date and time.

subset: commoncrawl


text:
#1 Dec 3, 2012
Slew is a lazy slob who drives a salvaged BMW but lives in ghetto inner city housing in his mamas basement. he also believes he has a solution to every little thing but in reality he dont know sh it expect leech off people's taxes and go shopping everyday.
typical gay armenian communist who hates america and would love to see a new communist empire
#3 Dec 3, 2012
If you were not of the typical Victim Mindset, you would know that history did not begin the day you were born. Historical context allows the adults to appreciate the Armenian reference and intelligence forces the grown ups to experience revulsion at the ignorance of you Sheeple that are allowed to vote!
Saint Paul, MN
#5 Dec 3, 2012
Ended, not vended.
#6 Dec 3, 2012
Yes, Bob is a Racist (Sorry if any are offended that I bring this back to the point of the Thread).
Saint Paul, MN
#7 Dec 3, 2012
Your post makes it very clear whick one of us is the bigoted racist.
#8 Dec 3, 2012
Knob Job Bob,
A free lesson for you.
Racists like you that attempt to "present well", fool nobody.
It does not matter whick way you attempt to spin it, you are to ignorant to hide your racial perspectives, that jade everything you post.
#9 Dec 3, 2012
Are you drunk already this morning, Consistent?
Oh, that's right, it is the third of the month and you just got your government check, so you are spending OUR loot on Phillips Vodka!
Saint Paul, MN
#10 Dec 3, 2012
Right. Tell that to the blacks, women, gays, Latinos and Asians that all voted overwhelmingly for the Democrats this year - they know which party is the racists.
You are the one that condones sickening people like Crassus that really don't even deserve to be Americans.
#12 Dec 3, 2012
Crassass is your King, poor queenie...
Smart Liberal
"The one and only Smart Liberal"
Since: Aug 12
Former MN Tax Payer
#13 Dec 3, 2012
CRASSUS doesn't deserve to be an Ameerican? Really?
Then how about the Rev Jeramiah Wright? The very same pastor that married the Obamas and baptized their children. He is a patriotic American, correct?
September 2001:The government lied about inventing the HIV virus as a means of genocide against people of color. The government lied.
September 2001:We bombed Hiroshima. We bombed Nagasaki. And we nuked far more than the thousands in New York and the Pentagon and we never batted an eye.
September 2001:We have supported state terrorism against the Palestinians and black South Africans, and now we are indignant because of stuff we have done overseas is now brought back into our own backyard. America is chickens coming home to roost.
April 2003:The government gives them the drugs, builds bigger prisons, passes three-strike laws and wants them to sing God Bless America. No! No No! God damn America for killing innocent people. God damn America for threatening citizens as less than humans. God damn America as long as she tries to act like she is God and supreme.
December 2007:Barack knows what it means living in a country and a culture that is controlled by rich, white people. Hillary would never know that.
December 2007:Hillary aint never been called a n*****. Hillary has never had a people defined as a non-person.
Jan. 13, 2008:Hillary is married to Bill, and Bill has been good to us. No he aint! Bill did us, just like he did Monica Lewinsky. He was riding dirty.
Fact number one: Weve got more black men in prison than there are in college. Fact number two: Racism is how this country was founded and how this country is still run.
"You cannot do terrorism on other people and expect it never to come back on you."
We are deeply involved in the importing of drugs, the exporting of guns and the training of professional killers. We believe in white supremacy and black inferiority and believe it more than we believe in God. We conducted radiation experiments on our own people. We care nothing about human life if the ends justify the means. And And And! God! Has got! To be sick! Of this shit!
"To say I am a Christian is not enough. Why? Because the Christianity of the slaveholder is not the Christianity of the slave. The God to whom the slaveholders pray as they ride on the decks of the slave ship is not the God to whom the enslaved are praying as they ride beneath the decks on that slave ship."
"We bombed Hiroshima, we bombed Nagasaki, and we nuked far more than the thousands in New York and the Pentagon, and we never batted an eye," Wright said. "We have supported state terrorism against the Palestinians and black South Africans, and now we are indignant because the stuff we have done overseas is now brought right back to our own front yards. America's chickens are coming home to roost."
"The government gives them the drugs, builds bigger prisons, passes a three-strike law and then wants us to sing 'God Bless America.' No, no, no, God damn America, that's in the Bible for killing innocent people. God damn America for treating our citizens as less than human. God damn America for as long as she acts like she is God and she is supreme."
"Barack knows what it means to be a black man to be living in a country and a culture that is controlled by rich white people. Hillary can never know that. Hillary ain't never been called a n-----."
Smart Liberal
"The one and only Smart Liberal"
Since: Aug 12
Former MN Tax Payer
#14 Dec 3, 2012
And Sludge is a racist of the worst kind. He also is a homophobe.
If I were the Democrat Party, I'd find a way to p*ss Sludge off so bad that he would join any other political party. Any one but the Democrat Party.
#15 Dec 3, 2012
Poor TrashyLiar, more moron gibberish, Hertz huh ?? LMAOROTFU~!
#16 Dec 3, 2012
"Hertz counter at Sea-Tac."
Oddly, THERE ISN'T ONE ~! LMAOROTFU~!
Since: Apr 12
Saint Paul, MN
#17 Dec 3, 2012
Let it go. You are a sad and miserable person.
#18 Dec 3, 2012
At least he's not a hippocrite.
#20 Dec 3, 2012
We not same person we just share brain
#21 Dec 3, 2012
Oh that's rich, coming from the biggest hypocrite on this site!
#22 Dec 3, 2012
"Hertz counter at Sea-Tac."
Oddly, THERE ISN'T ONE ~! LMAOROTFU~!
Let your LYING PALS WORDS GO ??? GFY slutty piff puff troll... LMAOROTFU~! Odd, you watched it day by day and never called it moronic...
Smart Liberal
"The one and only Smart Liberal"
Since: Aug 12
Former MN Tax Payer
#23 Dec 3, 2012
Hertz Locations:
Sea Tac HLE
19707 International Blvd Seattle Washington , United States
Hours of Operation: Mo-Fr 0730-1800, Sa 0800-1300, Su Closed
Since: Apr 12
Saint Paul, MN
#24 Dec 3, 2012
Slew, "moronic" is your never changing posts on this site. Enjoy yourself.
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WWE: A New Era Beckons
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The show begins with Jack Swagger standing in the middle of the ring in formal wear. The audience boos loud while Swagger holds a document in his hand and looks in a bad mood.
Swagger – "Last week, John Cena earned the right to be a part of Team RAW at Survivor Series (crowd pop). Ya, you all must be so happy and ecstatic because your hero will be fighting for your favourite show. But, I have some information which will change the way things seem right now."
He looks towards the document and then continues.
Swagger –"Now, Undertaker deemed it necessary to interfere last week and thus making Cena win the match. Let me tell you something Deadman, you just dug your own grave. (Swagger opens the document and continues) My sources have informed me that John Cena will screw Team RAW at Survivor Series. John Cena is an infiltrator from Smackdown and all his love for RAW is just an act. Now I do not know if Teddy Long or Wade Barrett is instrumental behind this gameplan, but John Cena being a part of Team RAW is the worst thing that can happen to our show."
The audience begins to chant "Cena,Cena,Cena" while Swagger sulks in disgust.
Swagger –"As John Cena earned his spot, Mr. Bischoff does not have the power to remove him from Team RAW. However, the captain of the team can remove any member he wants. So Deadman, you need to rethink your decision of siding by John Cena. And let me tell you something on behalf of our beloved General Manager Mr. Bischoff, if you decide to go ahead with John Cena, and Cena causes Team RAW to lose at SS, YOU WILL BE STRIPPED OFF THE WWE TITLE."
The audience begins to boo loudly.
Swagger –"Deadman, I will be awaiting your decision tonight. Think hard and make the correct choice, your one mistake can cost you the WWE Championship."
Swagger throws the mic on the floor and leaves the ring.
JR –"What is Swagger trying to prove? How can he be so sure that John Cena will turn on RAW"
Lawler –"Well JR, we all are as puzzled as you, and I will be awaiting The Undertaker's decision tonight. Well it's going to be either Jack Swagger or John Cena in the team at SS, and that depends on our WWE Champion."
MVP faces Shelton Benjamin:
The tag team partners have been banned from ringside. MVP takes control of the match and both of them being good workers give a great match. MVP wins the match by delivering the Playmaker when Benjamin misses a Superkick.
MVP def. Shelton Benjamin via pinfall at 7:24
Backstage, Bischoff calls and asks Rhodes to leave the arena as John Cena is looking for him. He gives Rhodes the night off and Rhodes leaves.
Josh Matthews interviews Miz and asks his thoughts on the match announced recently: Miz faces McIntyre in singles match at SS. Miz laughs it off and says that he is not concerned about a loser like Drew Mac and he will win it easily because he is the Miz and he is awesome.
3. R-Truth comes out to the ring. He begins to crib that he should be a part of Team RAW. Suddenly, his opponent comes out in a bad mood. Its Ezekiel Jackson who comes out alone without his manager. Jackson wins the match by delivering the Ura-nage.
Ezekiel Jackson def. R-Truth via pinfall at 4:02
4. Daniel Bryan comes out for his match. The opponent is Gregory Helms. Bryan wins via Lebell Lock submission.
Daniel Bryan def. Gregory Helms via submission at 5:39
Backstage, Christian meets Bryan and tell him that he is really happy to see such a technically gifted wrestler come to WWE. Bryan mentions he would love to lock hands with Christian to which Christian smiles.
Backstage, Sheamus and Punk stand with Josh Matthews who asks them about their enmity and how it can affect Team RAW's chances at SS. Punk replies that he is ready to forget the past for just one night where the prime objective is that RAW wins. Sheamus concurs and responds that his sole objective is to be the survivor who wins it for RAW. He look towards Punk who smiles and then suddenly turns a serious face.
6. John Morrison faces Big Show in a non-title match. Regal sits alongwith the commentators for the match. Morrison works on Show's bad arm and kicks it regularly to maintain the momentum. Show tries the chokeslam but Morrison comes out. Morrison is thrown out of the ring by Show and then Regal tries to mock him. Morrison snatches his title from the bell guy and when Show tries to lift him into the ring by his hair, Morrison hits him with the title to end the match via DQ.
Big Show def. John Morrison via DQ at 8:18
Morrison leaves with his title held high smiling while Regal stares at him from the ring.
The Undertaker comes out to the ring as the crowd awaits his decision. He takes the mic and proceeds to say.
Taker – "I stand by my decision, John Cena will be a part of Team RAW at Survivor Series."
Taker puts the mic down and proceeds to go backstage when suddenly the music hits.
(Barrett comes out to the ramp and stands there with a steel chair in his hand)
Suddenly, Batista, Orton, JBL and Kennedy come from the crowd from different directions and surround the ring. Taker looks around and does his boxing action asking them to enter the ring. All the four enter and attack Taker.
Barrett rushes to the ring and hits Taker with the steel chair on his head. The crowd boos loudly as the five Smackdown superstars begin to beat Taker. Suddenly, Punk and Sheamus rush down to the ring and attack Barrett's team but are soon over-powered. Del Rio rushes to the ring just after and he also gets beaten.
Barrett hits steel chairs on Del Rio and Sheamus. Punk is lifted by JBL and Barrett hits the steel chair on him. Suddenly, the crowd gives a humongous pop as John Cena rushes to the ring. Barrett asks his team to clear the ring and all the five rush down. Orton stands on the apron and begins to make strained faces wanting to enter the ring while Cena taunts him to enter it.
Barrett asks Orton to step down and all the Smackdown superstars leave through the ramp. Barrett looks towards Cena and smiles. Cena comes to the front in ring and taunts them to come back. Taker gets up slowly leveraging the ropes and Cena turns back. Taker locks his eyes on Cena and he looks unsure. The audience gives a huge pop as Cena realizes the mistrust developing there and keeps looking at Taker.
The screen fades to black.
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Modern and beautifully equipped apartment in unique ancient setting, as part of the cathedral square
Le Guillaume is a tastefully re-furbished apartment on the second floor of a very old building, once part of the Cathedral. We purchased in 2002, and had the entire apartment internally demolished, and re-designed to make it suitable for modern living in the 21st century, yet remaining part of a stunning medieval setting. The property is not suitable for young children or the very old. We do not recommend for two children either because of limited space. It has four rooms. A living area with the original ceiling oak beams, Victorian cast iron fireplace surround, and solid wood floors. The sofa bed is 4' wide, so unsuitable for 2 adults. Fine for one person.. Wi Fi connection. A kitchen which is part of this living area, cleverly divided with a breakfast bar, and with features such as lowered ceiling, spotlights and hidden extractor fan. A lovely bedroom with a "corona" over the bed, the whole room decorated in pinks and white, and a blue and white shower room, available to both guests in bedroom and those using the living room. The shower room boasts an Italian walk-in shower. The apartment is superbly equipped.
We do not allow animals in the apartment.
Top Traveller Review
Cozy, light and well located apartment in Bayeux
Dawn and Jean
About the Owner
About Dawn Petts
We are a retired couple who have been living in/visiting Normandy for many years. Jean is a French native having been born in St Lo and we met in Derbyshire in 1988. Jean has a brother and sister in Normandy. Our permanent home is in Derbyshire but we spend probably half of our time near to Bayeux. I am a retired Secondary school Head of Department and Mother to 6 boys, a family which includes 2 sets of twins and I am extremely proud of them. Jean is a widower, a retired University Lecturer, and linguist. Jean has 3 children, all successful business people. We are keen caravanners. I love my gardening, DIY, sewing and when I have time knitting too. Jean is at present learning Spanish, as we enjoy winter holidays in Spain and the Canaries. We look forward to further future travel.
Dawn Petts purchased this apartment in 2001
Why Dawn Petts chose Bayeux area
We went into the local notaire, and saw a very dull picture of the apartment. It was the location, as next door neighbour to William the Conqueror's' vast and impressive cathedral, that really made us buy it. Certainly not the appalling state it was in when we purchased! We realised that to do the job properly we would have to employ someone locally who could envisage from conception to reality exactly what could be achieved with the internal space available. This meant massive alterations, and at one point no internal walls were left standing. Parking is no problem, as just up rue de jurisdiction opposite the apartment, is a large square called place de Charles de gaulle, where parking is free, safe and shaded. On arrival it is easy to offload luggage right outside the apartment.
What makes this apartment unique
Right outside your door is the cathedral (no bells except on Sunday for services + for weddings/funerals). The area is quiet, and cobbled and picturesque. The bakers, boutiques and glorious selection of restaurants are all within a few minutes walk. Pop out first thing for your hot croissants. Stroll to view the tapestry, the various museums, the English war cemetery within easy walking distance. The supermarket E l'eclerc is 10 minutes walk away, so cooking in the lovely modern kitchen is not a problem. On days for travelling further afield try Arromanche, Deauville, Trouville, the beautiful and moving American cemetery at Omaha Beach, there is an abundance of things to do and see. The flat has lovely pink/white bedroom ideal for honeymooners,-space for 1 more in the living area.
10 Reviews
4.8/5 -
(10 traveller reviews)
Cozy, light and well located apartment in Bayeux
We spent 6 nights in this lovely apartment in Bayeux. I was initially worried that it might be too small for three of us (3 adults), but we loved it! I can't imagine a better location in Bayeux. The apartment is clean, comfortable and full of light. The bathroom is relatively large for the size of the apartment with a great shower. It was a pleasure to deal with the owner -- she responded to any questions within hours and all arrangements went without a hitch. We would stay there again in a heartbeat.
Great Location in a Charming Apartment
This lovely one bedroom apartment was perfectly located for all the things we wanted to do in this area of Normandy. It's downtown location made for a nice walk to dinner after driving all day. There are loads of restaurants and stores within walking distance.
The apartment was fitted with everything you could need. It was a very nice stay.
Cozy Apartment
Le Guilluame welcomes the weary traveler with its charming decor and with its historical location. Literally, next door to the Bayeux Cathedral and to the MAHB, the apartment's location is perfect. Add the proximity to the D-Day beaches as well as to the gorgeous Normandy countryside, you have a the perfection foundation for a great vacation. The kitchen is outfitted with all the necessary appliances to make wonderful meals for your Bayeux market day (Saturday and Wednesday weekly) purchases. Make sure you are comfortable with climbing stairs to reach this historically renovated apartment. Enjoy the comfort of feeling at home during your stay.
Great apartment
Our first trip to France was made so much easier with this wonderful apartment. Bayeux is such a beautiful city and this apartment puts you right in the heart of the historic area. The apartment is decorated in a very tasteful and comfortable way. It really made us feel at home when we arrived every night after a great day of seeing the wonderful sights in the area. The D-Day beaches and museums are so easy to reach from this location. If we are ever in that area again we would definitely want to stay here in this apartment. Dawn was a tremendous help to us getting there from Paris. She is a delight to work with.
Great apartment great location
My wife and I stayed here for a week from the 8th August. It is a great apartment in probably the best location in Bayeux central for all the bars and restaurants.It also is the perfect base for visiting the D Day beaches and Pegasus bridge.would definitely recommend
A delightful apartment, ideally located
My 3 nieces (15-23 y) and I had a wonderful stay in this perfectly situated apartment in Bayeux. It was a real treat to be literally right next to the beautiful cathedral, and a couple blocks from the Bayeux tapestry. We had a rental car and made easy day-trips to the Normandy beaches and the American Cemetery (a highlight of our trip), the Entretat Cliffs, and Mont Saint Michel. There were excellent restaurants steps from the apartment door and the apartment has everything needed for a comfortable stay. Dawn and Jean were friendly and professional from the initial contact to the prompt return of the security deposit. I would definitely recommend staying here!
From the Owner
"We went into the local notaire, and saw a very dull picture of the apartment. It was the location, as next door neighbour to William the Conqueror's' vast and impressive cathedral, that really made us buy it. Certainly not the appalling state it was in when we purchased! We realised that to do the job properly we would have to employ someone locally who could envisage from conception to reality exactly what could be achieved with the internal space available. This meant massive alterations, and at one point no internal walls were left standing. Parking is no problem, as just up rue de jurisdiction opposite the apartment, is a large square called place de Charles de gaulle, where parking is free, safe and shaded. On arrival it is easy to offload luggage right outside the apartment."
Activity and Interests
Normandy is one of France's most historical regions with a fascinating past which is intrinsically linked to that of English history, and therefore also to the history of many people globally.
Bayeux was the first city liberated by the Allies in 1944 and was pivotal to the their advances in Normandy. The UK War graves site is a moving reminder of this. Bayeux is close to the D-Day beaches and of interest to all visitors. The town is well equipped for English speaking visitors. The property is within 30 minutes' drive of Omaha Beach, the US Cemetery at St Laurent, the Mulbury Harbour and the Canadian Memorial. Under one hour is the German Memorial, St. Mere-Eglise, Utah, and Pegassus Bridge. Many well documented museums harbour relics of this recent past. Because Bayeux is the only town in Normandy not obliterated by air raids and artillery many early Middle-Ages features subsist. The Cathedral is nearly a mellenium, so is the Tapestry and they are next to you. Adam and Eve's timber house is just outside your window. Bayeux and its area is full of historical interests so many of them linked with the English speaking world.
The nearest beach is Arromanches, where the Mulberry Harbour is to be found. It is a pretty beach, with a very attractive town behind it. It has small shops and many cafes and restaurants as well as WW2 museums. Omaha Beach is very large, and even in summer relatively calm and quiet. This takes about 30 minutes's drive, and again there are several restaurants along the sea front.
The train station is about a 10 minute walk away from the apartment. Not so easy with suitcases, so take a taxi from just outside the rail station. Driving from the Port of Caen takes about 1.25 hours, and from Cherbourg about 1.5 hours, at comfortable speed. Driving from Le Havre takes about 1.75 hours. The cheapest ferries comes into Boulogne (ask owners for details) and Boulogne is 4 hours drive along good autoroutes (tolls applicable).
Parking for your vehicle is within 3 minutes walk.
Main street of Bayeux: Rue St Malo : 2 minutes walk.
Bayeux Tapestry : 5 minutes walk.
British cemetery: 10 minutes walk.
Bayeux war museum: 10 minutes walk.
Omaha beach and American cemetery: 30 minutes drive.
Caen: 20 minutes drive.
Cherbourg : one hour.
Le Havre 1.5 hours.
Boulogne/Calais : 4 - 4.5 hours drive.
Further Details:
The apartment is surrounded by excellent restaurants. However, inside, you have difficulty in believing that you are living in the centre of such an old city, because all guests report the living conditons are so very tranquil and quiet.
Prices and Availability
Rental rates
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Monthly *
|Event Price
My Standard Rate
3 night minimum stay
for 3 nights
* Approximate monthly price. Actual pricing will depend on the days of the month you stay.
Additional pricing information
|No additional mandatory fees
|Refundable Damage Deposit
Booking Notes:
To make an initial booking a 25% deposit is required.
Upon receipt we send you a Rental Agreement, with dates for final payment, details of where to send, and cancellation policy.
Final payment is required 3 weeks before holiday, together with 200 euro or pound sterling security deposit, which is returnable after the holiday.
Minimum 3 night stay.
Cancellation policy:
If within 59 days : Full refund given
If withng 30 days : 50% refund given
If within 2 weeks of arrival : no refund
Changeover Day:
Any day takeover by arrangement. Minimum 3 nights.
Arrival 14.00 hours
Departure 10.00 hours.
Notes on prices:
Please contact owners for discounts for either long summer lets, or long winter lets.
A 200 euro security deposit is required, which is returned after each visit, after inventory has been taken, and apartment checked for damage.
Owner's Cancellation Policy
- 12
- Available
- 12
- Unavailable
From the Owner
"Right outside your door is the cathedral (no bells except on Sunday for services + for weddings/funerals). The area is quiet, and cobbled and picturesque. The bakers, boutiques and glorious selection of restaurants are all within a few minutes walk. Pop out first thing for your hot croissants. Stroll to view the tapestry, the various museums, the English war cemetery within easy walking distance. The supermarket E l'eclerc is 10 minutes walk away, so cooking in the lovely modern kitchen is not a problem. On days for travelling further afield try Arromanche, Deauville, Trouville, the beautiful and moving American cemetery at Omaha Beach, there is an abundance of things to do and see. The flat has lovely pink/white bedroom ideal for honeymooners,-space for 1 more in the living area."
Property Type
- apartment
- Adventure
- Budget
- Historic
- Romantic
- Tourist Attractions
- Ceiling Fans
- Heating
- Internet
- Iron & Board
- Linens Provided
- Living Room ...
- Parking
- Telephone
- Towels Provided
- Tumble Dryer
- Washing Machine
- Coffee Maker
- Dishes & Utensils
- Dishwasher
- Freezer
- Kitchen ...
- Microwave
- Oven
- Pantry Items
- Refrigerator
- Hob
- Toaster
- Child's Highchair
- Dining
- Dining Area
- Books
- DVD Player
- Stereo
- Television
- Video Library
- wheelchair inaccessible
Location Type
- city centre
- near the sea
- town
- bay
- botanical garden
- churches
- cinemas
- forests
- library
- marina
- museums
- recreation centre
- restaurants
- ruins
- winery tours
Leisure Activities
- beachcombing
- bird watching
- horse riding
- paddle boating
- scenic drives
- sight seeing
- walking
Local Services & Businesses
- ATM/bank
- fitness centre
- groceries
- hospital
- laundrette - serviced
- medical services
Sports & Adventure Activities
- cycling
- equestrian events
- fishing
- fly fishing
- golf
- hiking
- mountain biking
- paragliding
- pier fishing
- sailing
- snorkelling
- swimming
- tennis
- water skiing
- wind-surfing
- Shower room 1 - Shower Enclosure
- The shower room is en-suite, with a second door leading into living area. It has blue and white Italian ceramic tiles on the floor and on the walls. The walk-in Italian shower has a curved see-through screen, and the toilet and wash-hand basin are white.
- 1 Bedroom, Sleeps 4
- Bedroom 1 - 1 Cot
- Description of sleeping capacity: Sleeps 2/4 (1 Bedroom + Sofabed) Notes on bedrooms: The bedroom has standard double bed, small dressing table and mirror, sliding door fitted wardrobe, with hanging space and shelves. There are matching pine side tables, lamps, and solid wood floors. The bedroom window overlooks the cathedral square.
- Golf ...
- Self-catering
House Rules
- Max. occupancy: 4
- pets not allowed
- non smoking only
- Notes on accommodation: The property is strictly non-smoking. No animals are allowed. Property too small for families with young children. The apartment is all electric - heating, cooking and lighting. The electricity is included in the rental price. Safe, shady parking nearby. All inclusive prices include taxe de sejour. all linen for bedroom, bathroom, and kitchen, wi fi connection, telephone. Absolutely no extras. Outside: There is a small gated yard in front of the apartment building. Some work is taking place summer 2012. The newly opened MAHB museum is attached to the apartment, and the living room windows overlook the impressive glass covered entrance to the museum. As evening descends, the pastel lighting inside the museum can be viewed through the living room windows, and the newly restored ancient arches are directly opposite, also gently lit at night. The museum was opened on 23rd March 2013 and is a great collection of Neolithic through to 19th century Art. The collection has been very tastefully displayed, with a great deal of attention to detail, and notes in both French and English. Spending time in Le Guillaume is an exciting and unique experience, as we have found out fir ourselves during this March, when the Museum was opened. Utility Room: As part of the living area, there is a sliding door cupboard, behind which, is the washer - dryer machine, clothes hanger, ironing board and iron, cleaning materials, hot water tank, and fuse board All very organised and compact, for easy holiday living. Cleaning / Towels / Linen / Maid service: All towels are provided, and the bed is made ready for arrivals. The extra bedding for the settee is in the bedroom wardrobe. There are tablecloth and napkins, and all kitchen linen is available. For visits of 2 weeks or more, weekly servicing available. Other: The main entrance of the apartment goes out onto a small landing, close to the spiral staircase.


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never get a office job!!
just me...sorry
hammock, diving, snowboard, to surf, shisha & steak ... to travel and taste all the delicious food!! guitar...
philippienes, best food ever!!
coral bay WA, best blueberry muffin...in whole australia!!
bali, best surfing spots!!
germany, best bratwurst and bread ..hehe
Visiting: Russia, Mongolia and China.
I have been in Thailand several times, last trip was 2009. Just ask and we will see.
» Ask studdicam a question about Thailand.
I traveled for 10 month all around australia, just ask and we will see cheers paul
» Ask studdicam a question about Australia.
I spend one month on the Philippines, and knowe the do and don'ts in that country !!
studdicam hasn't been active in the wiki travel guide yet. Have you?


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Mr George Patchett
Mr George Patchett was born in Wollaston, Northamptonshire, England in the closing months of 1892.
He was the son of George Henry Patchett (b. 1859), a boot-maker and later a castrator, and Eliza Rebecca Pratt (b. 1857), both Wollaston natives who were married in 1879.
George was one of five surviving children from a total of eight and his known siblings were: Annie Elizabeth (b. 1880) Emma (b. 1882), William (b. 1884), Henry (b. 1888), Elizabeth (b. 1890) and Annie (b. 1896).
He first appears on the 1901 census living with his family at Hinwick Road, Wollaston and he would still be present there by the time of the 1911 census when he was described as an unmarried boot factory pressman.
George and his friend John Garfirth, also a boot worker decided to emigrate to Canada where George had relatives and they were originally supposed to have travelled aboard the Empress of Ireland on 5 April 1912. Their attempts to join that ship were hampered by the coal strikes and they were forced to cancel and transfer to the Titanic which they boarded at Southampton on 10 April 1912 as third class passengers (ticket number 358585 which cost £14, 10s).
George Patchett died in the sinking and his body, if recovered, was never identified.
Both George's parents continued to reside in Wollaston; his father passed away in 1941 and his mother in 1946.
Nicholas Jardine-Patterson
Rob Scott
Link and cite this biography
(2017) George Patchett Encyclopedia Titanica (ref: #1120, accessed 22nd June 2017 04:30:02 PM)
URL : https://www.encyclopedia-titanica.org/titanic-victim/george-patchett.html
Let us know if you spot an error or want to add new information about George Patchett.
Leave a comment


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Target: Celene A. Seamen, principal of The Bishop Ready High School
Goal: Apologize for canceling a commencement speaker because of his affiliation with a marriage equality organization.
The Bishop Ready High School in Ohio canceled the invitation for one of their alumni to speak at their graduation ceremony because he supports marriage equality. The invitation to John O'Grady was extended two months before the ceremony. However, just days before the graduation it was canceled due to O'Grady's affiliation with Ohio's initiative "Freedom to Marry" that supports marriage equality.
The Bishop Ready High School is a local Catholic school in Columbus, Ohio from which John O'Grady graduated in 1982. He has since become a politician and an activist for marriage equality by becoming a co-chairman of the organization "Freedom to Marry" that campaigns for the right of same-sex couples to marry in the United States. In an interview to the Columbus Dispatch, O'Grady expressed his sadness over the situation, because he was looking forward to give the commencement speech.
The principal of The Bishop Ready High School, Celene A. Seamen, invited O'Grady to give the commencement speech and then canceled it after learning that O'Grady was involved with the human rights activism organization. By signing the petition below, you will ask the principal of The Bishop Ready High School to apologize for blatantly discriminating against the school's alumni and his involvement with a marriage equality organization.
Dear Celene A. Seamen,
In the anticipation of the 2013 graduation ceremony at The Bishop Ready High School, you invited the school's alumni, John O'Grady, to participate at the commencement speech. However, after learning that O'Grady is associated with an organization called "Freedom to Marry" – an initiative working to support same-sex marriage in the US – you cancelled your invitation just days before the ceremony.
I am asking you to apologize to Mr. O'Grady for cancelling his speech based on your discrimination of his involvement with the organization. Your actions show bad judgment of a successful individual who might have potentially given a wise and inspiring speech to the young high school graduates. John O'Grady is a community leader, working to protect American citizens, and your decision to cancel the invitation for him to give a speech at the ceremony denied your own students of being led by example.
[Your Name here]
Photo credit: Benson Kua via Flickr


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Former U-M Basketball Captain Passes Away
Dec. 3, 2013
Tom Jorgensen played at U-M, starting all 66 games during his three-year varsity career (1953-56). As a senior in 1955-56, Jorgensen captained the Wolverines and averaged 14 points per game, earning All-Big Ten honorable mention recognition.
After four seasons as a high school coach, Jorgensen began his collegiate coaching career at U-M, serving as an assistant from 1960-66. During his time on the Wolverine bench, Michigan won three consecutive Big Ten titles (1964, '65, '66) and reached a pair of Final Fours (1964, '65), falling in the national championship game to UCLA in 1965.


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Priddy Suicide Lists the Top Five Rock Songs To Dance To
The SuicideGirls are back out on the Blackheart Burlesque tour this winter. With stripteases and performances poking fun at Kill Bill, Game of Thrones, The Big Lebowski, Planet of the Apes, Dr. Who and more, it's unlike any other burlesque show. The new production will feature choreography from renowned instructor/dancer Manwe Sauls-Addison, who has worked with world famous performers such as Beyonce, Jennifer Lopez and Lady Gaga. One of the dancers on the tour, Priddy Suicide, told Revolver what her picks are for the Top Five Rock Songs to Dance To.
For more information on SuicideGirls' Blackheart Burlesque, check out the tour's official website.
5. Porcelain Black, "Who's Next" "Porcelain is beautiful and badass. She has this don't give a fuck attitude in her lyrics. Her music is like a mix of hardcore and pop. It has this raunchy masculine energy, but still has a feminine sense of empowerment."
4. Marilyn Manson, "Beautiful People" "Where the twisted and demented live beautifully, I love this song--and the video is pretty epic. It's raw and he takes it to another level that only a handful of artist are capable of."
3. Rage Against the Machine, "Killing in the Name" "This song is super thrashy and headbanging. It has a great build up too. I can give myself a good whiplash dancing to this song. Need I say more!?...I think not."
2. Killswitch Engage, "My Curse" "This song has so many levels of intensity and breathing moments. The transitions in the song are fun to play with when I'm dancing."
1. Nine Inch Nails, "Closer" "The song just drips sex. Its raw, provocative, and who wouldn't want to strip their clothes off listening to it? It's definitely a favorite of mine!"
Next Article


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Find your voice. A home for original thinkers, Essex gives you the skills and knowledge to succeed and make a difference.
Is there more to be said? Take your knowledge further, gaining the skills demanded by today's global employers.
Let's have an argument. Fuelled by powerful ideas, we have a global reputation for pioneering research which helps change lives.
We offer high quality short courses and Continuing Professional Development (CPD) opportunities to develop your key skills.
Everything you need on-site and home to students from 130 countries. It's the world in one place.
Specialist resources and state-of-the-art facilities in the heart of a vibrant and exciting seaside town.
Home to East 15 Acting School, offering a wide range of theatre and dance studios and facilities.
Home to students from 130 countries, we're one of the most international universities in the UK.
We're close to London with quick access to major airports and perfectly located for visiting Europe.
Innovative undergraduate and postgraduate courses and support to improve your language and study skills.
Scholarships are available for international students and we give advice on budgeting for life in the UK.
Our research changes the world, from protecting coral reefs to justice for human rights abuse victims.
Our leading academics are available for media interviews and consultancy across our subject range.
We're in the UK elite for social sciences, best in Britain for politics and top 20 for research excellence.
Our first TEDx event tackled issues from the rise of robot warriors to how we can save the planet.
If you're looking for a vibrant research environment and outstanding postgraduate training, welcome home.
The location of choice for knowledge-based science, technology and creative enterprises.
Our wealth of expertise is driving business forward. Where could consultancy or collaboration take you?
We'll help you find the right funding source for your R&D project or student engagement .
Our event facilities range from intimate meeting rooms to halls for up to 1,000 people.
Our latest cutting-edge research, commentary on current issues and what's happening at Essex.
Search the wide range of events happening at our three campuses and get involved.
Join fellow students from all departments and debate key cross-discipline issues that affect everyone.
Presenting research by our new professors.
We'll help you speak to our world-leading academics, find out more about us and organise events.
Register or log in and stay connected with us and the friends you made here.
Come to a reunion, a public lecture or an arts, cultural or sports event.
Find out more about the famous faces who studied at Essex.
Our alumni fund makes a huge difference to the student experience.
All our campuses have quick road, bus and rail links to London and major airports. We provide Access Guides for our buildings.
Find out how we achieve our mission of contributing to society through excellence in education and excellence in research.
We started small, but with big ambitions. Over five decades we have become one of the UK's leading academic institutions.
Marco Francesconi joined the Department in September 2004. Marco's main area of research is labour economics, with special interest in family economics, intergenerational links and labour market dynamics. His recent work has appeared in the Economic Journal, Journal of Labor Economics, Journal of the Royal Statistical Society, European Economic Review and Journal of Human Resources.
Marco has worked for nine years at the Institute for Social and Economic Research at the University of Essex, where he continues to be a Research Fellow. He is also a Research Associate of the Institute for Fiscal Studies (London), and a Research Fellow of the Centre for Economic Policy Research (London), the Institute for the Study of Labor (Bonn) and the Centre for Household Income Labour and Demographic economics (Torino).
<< Back


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Product description
ArtRage white up UV milk 35 ml is a UV milk of four plant extracts. Blending functions moisturizer and emollient ingredients and essence. There is also a sensitive sticking can even without the makeup remover off with SOAP (hypo-) prescription. It is SPF30 ・ PA ++. It is paraben (preservative) no fragrance, colorant, additive-free.
All the ingredients
Cyclopentasiloxane, zinc oxide, water, Dimethicone, BG, methacrylic acid methyl crosspolymer, titanium dioxide, PEG-9 polydimethylsiloxiethyldimechicon, ethanol, glycerin, gicaprin acid neopentilgu recall, pentylene glycol, placenta extract, horse chestnut extract, Paeonia albiflora root extract, hamamelis extract, soybean seed extract, Stearyl glycyrrhetinate, sysex, tocopherol, genussphingomonas extract, Aloe barbadensis, hyaluronic acid Na The Betaine, squalene, macadamia nut oil, diphenyl cyloxiphenyltrimechicon, gestalgimo of CT light, trimethylsiloxysilicate, PEG-10 Dimethicone, sulfate Mg, stearic acid, Methicone, hydroxide Al.
Product specifications
-Location: face
-Skin: sensitive skin, including skin texture in General
-Trouble: sensitive skin, allergic skin, sunburn, age spots, dry
Country of origin
For sunscreen face
Inflamed by UV rays and protects the skin from the harmful effects, such as black-Tan. In the particularly delicate facial skin care.About the [date view]
Shelf life for this item is displayed in the "Gregorian year / month / day" order.
|JP Post EMS
|Your order will be shipped to you via Japan Post EMS. Japan Post is a speedy delivery service that delivers to more than 120 countries. With an effective tracking system and insurance program, EMS is able to offer a secure delivery worldwide. You can track your package with the tracking code provided and it will be delivered within a week. See estimated shipping fee
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When EMS use, no charge up to the article value equivalent to 20,000yen.
Then premium (additional charge) of 50yen will be added per 20,000yen.
If you order more than 20,000yen (exclude shipping cost),
you have undertaken the procedure to enter additional charge for covers all fees.
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5. Later, we will shipping you new items.
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Yum-Yum Bento box
Usually dispatched within 24 / 48 hours (business days).
Your kids will love this cookbook as much as you will!
Yum-Yum Bento box is full of instructions, recipes and tips on how to make fun, colourful, kawaii and healthy meals (ノ^∇^)!
Product Description
Kyaraben are Bento boxes where cuteness is at the centre! With these recipes you'll be able to create super cute kawaii bento boxes that are as beautiful to see as to eat!
The authors, Crystal Watanabe (from the blog Adventures in Bentomaking) and Maki Ogawa features about 50 recipes of kid-friendly meals. The pictures and step-by-step instructions make it easy to understand and replicate. Also included is a helpful shopping guide and glossary at the end of the book.
Get cooking (ノ^∇^)!
- Dimensions : 20cm x 19cm
- Length: 144 pages
- Edited in 2012. Printed in China.


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ESW is a specialist contractor with expertise in delivering innovative construction, waterproofing and coatings solutions. Our installations range from smaller residential treatments through to large-scale commercial applications and are designed for resilience and longevity. With our fully trained team of operatives, we deliver a high level of workmanship, always with an eye on quality. Since 2009, we've been the market-leading application specialists of Prokol pure polyurea roofing, anti-slip and containment systems. Using superior product ranges from Prokol pure polyurea, Kingspan insulation and Protan single ply roofing systems, we deliver value through our bespoke waterproofing, anti-slip surfacing and failsafe encapsulation solutions.
Whether you require a watertight roof, a sealed basement, an anti-slip floor or a coating for a special project – we'll provide a dependable solution designed to last for decades.
Among our services:


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Glowing Eye Mask Uses Meditation Techniquies For A Good Night's Sleep
GLOtoSLEEP masks use Photo-Luminescents to deliver a healthy drug-free rest.
The GLOtoSLEEP therapeutic sleeping mask from Sound Oasis uses light-charged photo-luminescent bars to lull its wearer to sleep. The design aims to improve upon flimsy and ineffective sleep masks, and exposes opportunities for sleep enhancement in the travel and hospitality industry. The masks were handed out to nominees at a pre-Oscars event held at the Beverly Hills boutique L'Ermitage Hotel last week.
GLOtoSLEEP uses a patented system of light-charged photo-luminescent bars, which give the wearer a healthy drug-free sleep, by emulating an Eastern meditative process of "looking up" to clear the mind. They are made from hyper-allergenic foam with an adjustable Velcro strap and weigh less than half an ounce. GLOtoSLEEP is available in the U.S., Canada, UK, Europe and Australia, at a price of $39.99. Peter Mackeonis of Santa Cruz Holistics, a GLOtoSLEEP U.S. distributor, said:
We seldom meet a celebrity capable of sleeping more than a few hours a night. Hollywood is clearly a town that never sleeps, but wants to. Many celebrities come back just to tell us how much they love their GLOtoSLEEP and to pick up an extra one for traveling… Anyone who has flown long distance knows that airline sleep masks offered by even the major carriers such as American Airlines, Continental, BA, Air France and even Virgin Atlantic, are uncomfortable, flimsy and aren't black-out masks.


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More fantastic work from the forwards last weekend in Dunedin laid the platform for two outstanding tries from Gio Aplon and Joe Pietersen, in what was the Highlanders first loss at home this season.
Read More
Read More
« DHL Stormers to take on the Crusaders announced | Main | Vodacom Super Rugby Preview – Round 8 »
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The comments to this entry are closed.


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First, unless you are a qualified gunsmith... take your Dremmel, and put it as far FAR FAR away from your gun as possible, please!
I'd first check that when you put it back together that you lubed it according to the manual.
Then I'd try those mags again at capacity -1 and see if it happens again. If it doesn't, it could just be that the gun is new and needs to be broken in a bit (load down a round until the magazine breaks in a little)
Just as important as not riding the mag release, is not riding the slide release. It can cause problems as well.
As to WWB being dirty, I've not really noticed too much of a difference, but I clean my guns after every session.


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Need info on Corbin's Rods
A friend of mine is thinking of buying a '34 coupe and chassis from Corbin's Rods of Valdosta, Ga. Has anyone had any dealings with this company or know about the quality of their products? I checked the 'company reviews' and found nothing.
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The Three Pillars of Blog Traffic
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Ace Atkins's Southern Discomfort
Going DIY for Travel Tips
New Titles from Self-Publishers: June 2017
The Call-In: Your Questions About Making Relationships Last
A New Delhi Family Learns To Navigate Wealth After A 'Windfall'
An Ancient Curse Awakens In 'The Suffering Tree'
'But Seriously,' Tennis Great John McEnroe Says He's Seeking 'Inner Peace'
'Interlaced Fingers' Traces Roots Of Racial Disparity In Kidney Transplants
By the Book: Emma Straub: By the Book
20 Years of L.G.B.T.Q. Lit: A Timeline
Nonfiction: How Uber and Airbnb Became Poster Children for the Disruption Economy
For These Collaborators, There's No 'I' in 'Best Seller'
Open Book: Class Ed.
sketchbook / graphic review: 'The Better Angels of Our Nature'
The Book Review Podcast: 'The Boy Who Loved Too Much'
Nonfiction: A Trip to Southern Italy to Shed Light on a Family Scandal
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CANADA STOCKS-TSX broadly rises, led by banks and telecoms
* TSX up 120.85 points, or 1.01 percent, at 12,063.02
* Nine of the TSX's 10 main groups were higher
TORONTO Jan 19 (Reuters) - Canada's main stock index rose more than 1 percent in morning trade on Tuesday, led by financial shares and helped by telecoms and some consumer stocks.
The move echoed a similar gain for U.S. indices, which were closed for a holiday Monday when Toronto fell 1.1 percent.
Shares in Europe and Asia also rose as data showing China's economy grew last year at its slowest pace in a quarter of a century led investors to anticipate more efforts by Beijing to spur growth.
At 10:09 a.m. EST (1509 GMT), the Toronto Stock Exchange's S&P/TSX composite index was up 120.85 points, or 1.01 percent, at 12,063.02. It is just off its lowest levels since June 2013.
Oil prices were pressured by an Iranian order to sharply increase output, although data pointing to record Chinese oil demand in 2015 boosted sentiment.
The energy group climbed 1.3 percent.
Banks and other financial stocks were influential, with Royal Bank of Canada up 1.1 percent to C$67.57 and Manulife Financial Corp adding 1.1 percent to C$18.06. Continued...


text:
Table Of Contents
New Software Features in Cisco IOS Release 12.2(14)SZ
Product Bulletin, No. 2163
Cisco IOS Early Deployment Release 12.2(14)SZ
This Product Bulletin describes the content and delivery information concerning Cisco IOS® software release 12.2(14)SZ on the Cisco® 7300 Series Router. For more information about the Cisco IOS software release process, please see Product Bulletin #537 at:
The Cisco 7300 Series routers are optimized for flexible, scalable, high-performance IP/MPLS services at the service provider and enterprise network edge. Providing powerful processing, a broad set of interfaces and a compact form factor, the Cisco 7300 Series routers are ideal for feature rich, multigigabit network applications.
The Cisco 7304 router is a mid-range, price/performance optimized router that utilizes a compact (4 Rack Unit), modular (4 slot) form factor. It delivers high-performance services in IP/MPLS networks and is optimized for the network edge where the service provider meets the enterprise. Targeted applications include service provider PE and IP edge router as well as service provider managed service customer premises equipment (CPE) or enterprise Internet gateway and enterprise WAN aggregation.
New Software Features in Cisco IOS Release 12.2(14)SZ
Detailed information about software features delivered in Cisco IOS Release 12.2(14)SZ is described in the respective release notes at:
Tables 1 describes the new hardware features now available on the Cisco 7304 in Cisco IOS Release 12.2(14)SZ.
Table 2 describes the software features now available in the PXF-switching path on the Cisco 7304 in Cisco IOS Release 12.2(14)SZ.
Migration Guide
Release 12.2(14)SZ is parented off of Release 12.2S(RLS2). Table 3 below identifies the recommended migration path.
Table 3 Cisco IOS 12.2(14)SZ Migration Guide
Functionality in This Release Will Be Available Next in 12.2(14)SZ
Cisco IOS software release 12.2(14)SZ follows the standard Cisco support policy as indicated in the following link:
Product Numbers
Table 4 describes the available feature sets, product ordering codes, image names, and memory requirements for Cisco IOS software Release 12.2(14)SZ.
Download Information
Customers can download Cisco IOS Release 12.2(14)SZ software from the Cisco Software Image Library:


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Sarah Williams thought she was through with her Labyrinth problems. They were only just beginning...good thing help is on the way. Or is it? Crossover with Roger Zelazny's 'Chronicles of Amber' ser...
This is a poem that I wrote when I was thinking of everyone's favorite Goblin King, Jareth. Wrote back in 2000.
A little OOC(Out of character) Sarah is Wife and Queen to the Goblin king, but even the Goblin king has needs. It's NC-17 because I want to be certain.I Tried to make it tasteful.
What happens when you mix a bird-eating, crystal stealing goblin, an irate goblin king, a petshop, and a bookworm Sarah? You get this summary...and this story. Featuring Garbo, my resident plot-gob...
At the end, he had given her a choice, His love or her brother. She chose her brother. Can a little girl's wish give them the happy ending they deserve?
Lisa Alomore broke out of a all male prison where she didn't belong. She finds herself in the labyrinth and asks the king to let her finish some unfinished business.Please read and review.Don't own!
Sarah Williams defeated the Goblin King and got her brother back. 23 years later, Kimber Muse, Sarah Williams daughter is forced to go visit her father, the one person she hates for the summer. As ...
Jareth returns to save Sarah from a man on the street. However, there are other reasons why he has returned. A horrible summary, if I do say so myself, but ya gotta read it to love it!
Her name was Isis. She had fallen into a world of confusion and mystery. Till a king arrived in her name. Jareth... what was so special?
Earth is at War
After leaving the Labyrinth, Sarah finds things...lacking. A series of five vignettes of increasing length describing Sarah's descent into darkness. For The Starving Writer's challenge.
Well, there's a bad guy, a girl, inter-dimentional time travel. Oh and Jareth. What more can you ask for?
Sarah is an Underground courtesan, Jareth is a king with a dark mission. Neither have time for the deep passion between them.
15 year old Julia confidently accepts Jareth's challenge to complete his Labyrinth in search of her brothers. She suprisingly finishes his Labyrinth and is soon brought face to face with the king h...


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Bucs acquire catcher and designate McKenry for assignment
The Pirates acquired reserve catcher Chris Stewart from the New York Yankees on Monday for a player to be named.
To clear room on the 40-man roster, the Pirates designated catcher Michael McKenry for assignment.
Stewart is a strong defensive catcher. He possesses a skill that is prized by the Pirates — the ability to frame pitches. Stewart was second in baseball in turning balls into called strikes, 22.7 runs above average, according to Statcorner.com.
He trailed only Brewers catcher Jonathan Lucroy and ranked ahead of Cardinals Gold Glove catcher Yadier Molina in framing. Pirates starting catcher Russell Martin ranked sixth while McKenry was slightly below average in that category.
Stewart also will improve the Pirates' ability to control the running game. Stewart threw out 17 attempting base stealers in 2013, tied for fifth in the American League. He has thrown out 33 percent of base stealers for his career, which covers parts of seven major league seasons with the Yankees, Giants, Rangers, Padres and White Sox. McKenry threw out just six of 41 base stealers in 2013 and 19 percent for his career.
Stewart is out of option years and is in line to open the season as Russell Martin's backup, the same role he held in New York in 2012. Tony Sanchez likely will open the season in Triple-A.
"We were drawn to the defensive package, the man and the fit on the club," Pirates GM Neal Huntington said. "This move gives us solid catching depth at the upper levels while potentially allowing for significant development at-bats for Tony (Sanchez)."
The Pirates announced Stewart agreed to a one-year deal to avoid arbitration before the trade was completed. The Yankees added catching depth with the signing of free-agent catcher Brian McCann last week, allowing them to part ways with Stewart.
"I wanted to stay in New York, finish my career with the Yankees, but too many guys were there and I was the odd man out," Stewart told the Wall Street Journal. "But they sent me to a place where I'm wanted, and I'm going with open arms."
Stewart also is the answer to a trivia question. He is the last player to catch a Mariano Rivera save.
Stewart, 31, like McKenry, is not much of an offensive threat. The right-handed hitter batted .211 over 294 at-bats for the Yankees last season with four home runs and 25 RBIs. For his career, he's a .214 hitter.
The acquisition ends McKenry's time with the Pirates. McKenry hit .217 last season.
Wrote McKenry on his Twitter account Monday: "It's been an honor to wear a Pirates jersey & dive into the Pitt community over the last few years. It's difficult to part ways with the city."
McKenry missed the last two months of the season after undergoing surgery to repair a torn meniscus in his left knee.
Sanchez became the backup catcher and the Pirates later traded for John Buck, who is a free agent and not expected back with the organization. McKenry figured to be a non-tender candidate Monday before the addition of Stewart.
Note: Evan Chambers, 24, the Pirates' third-round draft pick in 2009, died in his sleep over the weekend. An outfielder, Chambers hit a combined .191 with a .585 OPS with High-A Bradenton and Double-A Altoona in 2012. He played in only four games this season because of a foot injury.
Staff writer Rob Biertempfel contributed to this report. Travis Sawchik is a staff writer for Trib Total Media. Reach him at firstname.lastname@example.com or via Twitter @Sawchik_Trib.
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We moderate comments. Our goal is to provide substantive commentary for a general readership. By screening submissions, we provide a space where readers can share intelligent and informed commentary that enhances the quality of our news and information.
While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. We will make them as carefully and consistently as we can. Because of the volume of reader comments, we cannot review individual moderation decisions with readers.
We value thoughtful comments representing a range of views that make their point quickly and politely. We make an effort to protect discussions from repeated comments either by the same reader or different readers
We follow the same standards for taste as the daily newspaper. A few things we won't tolerate: personal attacks, obscenity, vulgarity, profanity (including expletives and letters followed by dashes), commercial promotion, impersonations, incoherence, proselytizing and SHOUTING. Don't include URLs to Web sites.
We do not edit comments. They are either approved or deleted. We reserve the right to edit a comment that is quoted or excerpted in an article. In this case, we may fix spelling and punctuation.
We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly.
We appreciate it when readers and people quoted in articles or blog posts point out errors of fact or emphasis and will investigate all assertions. But these suggestions should be sent via e-mail. To avoid distracting other readers, we won't publish comments that suggest a correction. Instead, corrections will be made in a blog post or in an article.