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This property has been removed by the agent. It may be sold or temporarily removed from the market
Residential Development for sale293 - 295 Tavistock Road
Property Description
Full description
Wardour House is located only 3 miles North of Plymouth City Centre and is conveniently located close to the airport, Derriford Hospital, business and retail parks and all major road and rail links.
Plymouth is located just over 40 miles from Exeter, 110 miles from Bristol and 220 miles from London. Plymouth is the nearest city to Cornwall, this enables it to have a large catchment area.This city has a population of approximately 250,000, more than double the population of the second largest city in Devon, Exeter, and a population of 350,000 within 12½ miles (20 kilometres) of the centre. The main focus of redevelopment is in the centre of the city, with sites such as Millbay and Devonport due to come forward over the next few years. The city is a major maritime centre for the navy and yachtsman alike. Plymouth is popular for water sports and there is a regular car ferry service to France and Spain. Plymouth is one of the main domestic navy ports in southern England and the largest navy base in Europe.
There is a main line station within Plymouth providing a regular service to London Paddington and the remainder of the country to the north and local services throughout Devon and Cornwall. The city has good road links via the Devon expressway A38 to the M5 and A30 to the north. The airport offers flights to a number of destinations within the UK and Europe.
The premises comprise a pair of substantial semi detached properties that are inter-connecting, and at one time functioned as a nursing home. The previous owners to our client, have extended the property and created the current configuration.
Planning Consent has been sought and granted to change the use of the properties to form two houses in multiple occupation, one containing 17 bedrooms and one containing 10 bedrooms, for use as student accommodation in March 2011. Application no' 10/01548/FUL.
Externally there is parking for approximately fifteen vehicles, as well as a double garage. A small garden area can be found to the north west of no' 295, in addition there is lawned area immediately to the front elevation of the premises.
The premises have a registered HMO Certificate.
293 Tavistock Road.
17 bedrooms, of which 8 are ensuite.
Lounge/dining room
3 kitchens
Laundry room
Further communal bathroom, additional shower room and 2 WC's
Private courtyard
295 Tavistock Road
10 bedrooms, of which 2 are ensuite
Lounge/dining room
3 kitchens
Further communal bathroom and 2 WC's
Small rear garden
Double garage
We understand that all mains services are connected to the premises. We have not tested the apparatus. Our client is able to provide gas and electric safety certificates.
The premises are available Freehold and further details are available upon request.
Each party to bear their own legal costs incurred in the transaction.
There is parking for approximately 13 vehicles plus a double garage
Planning Consent to change the use to form two houses in multiple occupation, one containing seventeen bedrooms and one containing 10 bedrooms, for use as student accommodation in March 2011. Application no' 10/01548/FUL.
Contact the Sole Agents - Maitlands Commercial
Mark Slade - 01752 661234 / email@example.com
More information from this agent
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/commercial-property-for-sale/property-33106075.html
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Disclaimer - Property reference 100198000009. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Maitlands , Commercial. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
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Open-source project used volunteers to prepare data exchange standards
The Health and Human Services Department's open-source Direct Project development program for secure health data exchange over the Internet has started operating in two states, Minnesota and Rhode Island, and will launch demonstration projects in six more states, officials have announced.
The Direct Project is an offshoot of HHS' Nationwide Health Information Network, a set of protocols for secure health data exchange between federal health agencies. Direct Project started last year with HHS support to spur health data exchange among a larger group of participants. Earlier, a similar effort was known as the NHIN Direct project.
The goal of Direct Project is to develop an open-source, interoperable and easy-to-use tool to enable secure Internet transmission of sensitive health data, replacing mail and faxed transmissions. Volunteer developers from more than 60 organizations and companies came together in 2010 to write common standards and technical specifications for Direct Project.
Winners and losers under the NHIN Direct project
"This is an important milestone in our journey to achieve secure health information exchange, and it means that health care providers large and small will have an early option for electronic exchange of information supporting their most basic and frequently needed uses," Dr. David Blumenthal, HHS' national coordinator for health IT, said in the release.
If the pilot demonstrations are successful, the Direct Project technologies will be available across the country by 2012 to spur adoption of electronic health record systems by doctors and hospitals. The economic stimulus law of 2009 provided $20 billion for that effort.
Aneesh Chopra, the White House's chief technology officer, said Direct Project is an example of using stakeholders to create innovation.
"This is a new way of doing the public's business, and it works," Chopra said. "Instead of the traditional top-down approach, it calls on stakeholders to work together in a more open and fast-moving way to achieve results. It makes government a platform for innovation by those who really know the field."
The next states to begin demonstrations are California, Connecticut, New York, Oklahoma, Tennessee and Texas.
About the Author
Alice Lipowicz is a staff writer covering government 2.0, homeland security and other IT policies for Federal Computer Week.
E-Mail this page
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Read the profiles of all this year's winners.
Click here for more
The Trump administration has nominated Ellen Lord, president and CEO of defense contractor Textron Systems, to serve as undersecretary for Acquisition, Technology and Logistics.
Steve Kelman gives kudos to DHS' Soraya Correa for facing the FLASH cancellation head-on.
DHS officials confirmed for the first time that Russian hackers tried to penetrate voting systems in 21 different states in the run-up to the 2016 election, but said the hacking did not affect election results.
After coming to terms with Cerner on a price for its electronic health record system, VA expects to pivot to finding an integrator to handle legacy interoperability and change management.
Current restrictions on internet gateways complicate agencies' move to the cloud, so the Office of Management and Budget is exploring new security architectures.
After announcing it would switch to a commercial electronic health record system, the Department of Veterans Affairs must race to make a deal with Cerner.
8251 Greensboro Drive, Suite 510, McLean, VA 22102 | 703-876-5100
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subset: commoncrawl


text:
|Software Title
|Avidemux 2.5 from Avidemux (Open Source Software) - Company Website »
|Avidemux is a free video editor designed for simple cutting, filtering and encoding tasks.
|Windows, Mac, Linux
|Windows 10 Compatibility
|Win 8 Compatible - A download site states that it is Windows 8 compatible
|Installable on personally owned computer?
|Yes - but check 'Licence Summary' below for specific restrictions
|Licence Summary
|Freeware licence available to everyone.
|Available in/on:
|Install software on your computer:
|Install Instructions for Avidemux »
|Information for Administrators
|Administrators may click for more information ⇓
Note - Site Licensed software is for use by members of Lancaster University who fulfill the criteria stipulated by the precise terms of the licence agreement.


text:
Hello every body,
I followed this website before my surgery and wanted to write a review after my own. I had my surgery Friday December 2nd. I did not now exactly what to expect, but I definitely did not expect this.
I am and have been in much more pain and discomfort than I was told. The doctor and nurse both promised me that I would feel sore, but would able to return to work within 2 days. Friday night was horrible, but it got even worse once all the numbness and medicine wore off. Yesterday might have been the worst. I am not able to do anything. Cant stand up because I can't use my legs or my arms to push up.
The first 24 hours I bled through my bandages and stockings. My doctor told me to come in, the day after surgery and he removed all the bandages and compression stockings. He told me to use my own and come back within a few days.
I was in so much pain that night that I got up and cut off my own compression stockings as my ankles and toes looked like they were about to burst! There was so much swelling and throbbing that I was in tears. Had to get a size larger the following morning. Wish he would have checked them before I left his office.
I was also promised minimal bruising, but my arms and legs are completely filled with huge dark and light bruises. Looks horrible. My elbows have yet to stop bleeding.
Can anyone help me feel a little better? I am very happy with my surgeon, but Im still a little nervous. Has everyone else had this much pain??? I will upload photos when I have the chance.
Vaser Liposuction Ankles, Knees, Thighs, Arms - Chicago, IL
Hello every body, I followed this website...
Hello every body,
Not decided on a rating until I see my results. I know my surgeon is one of the best...but still have to wait and see.


text:
Quick Links
A-Z | Portals | Blackboard | eCollege | Web Mail
Iman Mohamed migrated to Denver, Colorado from Sudan with her mother and siblings soon at the age of eight after her father's arrival to the United States. With hard work and determination, she managed to overcome the language barrier and achieve the dream of attending college. She is a sophomore at the University of Colorado Denver majoring in Ethnic Studies. Majoring in Ethnic Studies will further develop her understanding of others as she greatly values multiple perspectives. With the help of the Daniels Fund scholarship, the BA/BS-MD program, the Undergraduate Pre-Health Program, and an Ethnic Studies Major, Iman hopes to develop the personal and professional skills necessary to become the most caring physician she can be. Outside of college, Iman loves to be outdoors enjoying the beauty of nature, volunteering with kids, listening and dancing to music, playing tennis, as well as being in the company of her friends.
Office of Inclusion and Outreach
University of Colorado Anschutz Medical Campus
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Accredited by the Higher Learning Commission. All trademarks are registered property of the University. Used by permission only.


text:
Was Royal Hoax Nurse Found Alive at Suicide Scene?
Conflicting reports are circulating over Jacintha Saldanha's condition when authorities arrived at her suicide scene in London on Friday.
Autopsy results for the 46-year-old nurse, who allegedly hanged herself, are expected on Thursday. A suicide note left for her husband and two teens surely sheds further light on what happened, but has not been made public.
Jacintha was the nurse on duty last week when two Australian deejays called King Edward VII's Hospital posing as Queen Elizabeth and Prince Charles and inquiring about mommy-to-be, the Duchess of Cambridge, Kate Middleton. She patched the call through to a nurse in Kate's ward.
[Jacintha's husband Ben Barboza, center, and daughter Lisha and son Junal / Getty Images]
Saldanha's family was reportedly not aware that she was involved in the royal hoax and husband Ben was concerned after he couldn't reach her for two days. He called a friend at the hospital's staff housing, where she stayed on weekdays, looking for her the night before her body was found, but never heard back.


text:
Financial Software
Financial Software Questions? Ask IT Support for Answers ASAP
shift doesn't work- same thing- not responding. Control brings up "file" which obscures most of the Quicken tool bar.
Not sure what that means, but I can click on file, and several tbhings come up, including "9/23 data (or somethiung like that)
As I just said in my previous message (before this answer- sorry) I was able to open the Quicken file, but with the same results.
Windows 7
OK, but won't I lose this session if I close and then restart the computer?
I may have already sent this, but on the wrong page. I got to "uninstall" but saw no way to "change" or "repair"- only "uninstall", and I don't want to lose my Quicken data.
Richard- I uninstalled Quicken and restarted my computer. Now I can't find out how to reinstall it.
via download- I don't have a CD.
Better yet, I apparently ordered a 2013 upgrade CD. If I use that it will work just as well-right?
OK- I'll get back with results.
By the way, do I have to pay for it again?
Got to the site- logged in- went to downloads-unlocks- said there were none- see no way to order rather than pay. Called the custyomer care number shpown on the site, which twice said thanks for calling and then disconnected.
Absolutely- I'm looking at previous ID's and maybe that will do it- I'll let you know.
Got the right ID- downloading now- will confirm when finished and data located.
Successfully downloaded, but when asked which filew to open, the current one doesn't show up. Can't find the current data. I know it showed a date of 9/23/13 eqrlier today when qwe first tried to open the file. What now?
I never named it anything. it was originally downloaded and accepted the data already there with no problem. I don't knjow how or where to search for it. It has to be here somewhere but the list of QDATA entries does not include it.
There are none. There's a box that asks for it/.
Sorry-found it 636-310-037


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Culinary smackdown: Food writers compete to feed six for fifty dollars
Feed six people for fifty dollars? No problem. No problem that is until you realize what your competition is serving. When the New York Times asked two of their food writers to create menus for dinner parties on a strict $50 budget both of them quickly realized they couldn't offer chicken and salad, not when their competition was dishing up tilefish ceviche in handmade tortilla chips or cheddar gougeres and Jean-Georges desserts. In this culinary Thunderdome, it's Julia Moskin versus Kim Severson and they are battling it out for best budget dinner party. The judge? Frank Bruni, the feared New York Times food critic. They join The Takeaway for a reenactment.
The story of their dinners, Comrades at Arms: Two Food Writers in a Kitchen Smackdown, is in today's New York Times.Recipe Files: Kim's Tacos de Carnitas
Adapted from Tara Duggan, The San Francisco Chronicle
Time: 2 1/2 hours
- 3 pounds pork shoulder, either butt or picnic
- 7 strips orange zest
- 5 garlic cloves, minced
- 1 large onion, chopped, plus finely chopped onion for garnish
- 1 1/4 teaspoons crushed red pepper flakes
- 1 cinnamon stick, preferably Mexican canela
- 2 bay leaves
- 1 1/2 teaspoons crushed dried oregano leaves, preferably Mexican
- 1 1/2 teaspoons kosher salt, more to taste
- 1/4 teaspoon ground cloves
- 24 small corn tortillas, warmed, for serving
- Chopped cilantro for garnish
- Salsa for garnish.
- Trim any thick fat from surface of pork. Cut meat into 1-inch cubes, discarding any that are pure fat. Put pork in a large pot. Add enough water to cover by 2 inches, orange zest, garlic, chopped onion, red pepper flakes, cinnamon, bay leaves, oregano, 1 1/2 teaspoons salt and the cloves.
- Bring to a boil, then reduce to a simmer. Skim off any scum that forms on surface. Simmer uncovered for 1 1/2 hours, until pork is very soft; add water if necessary to keep meat submerged. Season with salt, then continue to cook until water has evaporated, about 30 minutes. Cook a little longer to fry meat slightly; cook even longer if you prefer crisper meat. Stir often and add a bit of water if meat sticks or seems about to burn.
- Remove bay leaves and cinnamon stick. Spoon a few tablespoons of carnitas onto each tortilla. Top each taco with cilantro, finely chopped onion and salsa. Serve.
Yield: 6 to 8 servings.Julia's Tangerine-Vanilla Floats
Adapted from "Sunday Suppers at Lucques" by Suzanne Goin with Teri Gelber (Knopf, 2005)Time: 10 minutes
- 6 large scoops vanilla ice cream
- 3 cups freshly squeezed tangerine juice (from about 12 tangerines) or orange juice (see note)
- Seltzer
Yield: 6 servings. Note: Fresh orange juice can be used instead of tangerine juice, but it should be very sweet and not too acidic. Try adding superfine sugar to taste.
Want more recipes? Click here. Kim's Chili-Spiced Peanuts
Adapted from "Simply Mexican" by Lourdes Castro (Ten Speed Press, 2009)
- 1 cup roasted, unsalted peanuts
- 3 tablespoons sugar
- 1 teaspoon cayenne pepper
- 1 teaspoon coarse salt or kosher salt
- 1 lime, quartered
- In a nonstick pan over high heat, toast peanuts for 2 to 3 minutes, shaking pan or stirring often until nuts begin to smell toasty. Pour into a bowl and set aside.
- Decrease heat under pan to medium and sprinkle sugar, cayenne pepper and salt evenly into it. Melt mixture slowly, stirring a bit with a heat-proof silicone spatula. When sugar has melted, add peanuts to pan and coat well. Mixture might clump a bit.
- Pour nuts onto parchment paper. As soon as mixture is cool enough to handle, break apart any clumps of peanuts. Serve with wedges of lime. Squeeze lime over nuts right before eating.
Yield: 1 cup.
Julia's Pasta With Roast Chicken, Currants and Pine Nuts
Adapted from "The Book of Jewish Food" by Claudia Roden (Knopf, 1996)
Time: 45 minutes
- 3 1/2 pounds bone-in, skin-on chicken thighs, patted dry
- Salt and freshly ground black pepper
- Paprika
- 3 tablespoons unsalted butter
- 1 1/2 pounds dried pasta, preferably bucatini or linguine
- 2 teaspoons crumbled dried rosemary
- 1/2 cup dried currants or raisins
- 2/3 cup pine nuts, toasted
- 3 tablespoons chopped parsley.
- Preheat oven to 375 degrees. Arrange thighs in a large roasting pan, preferably nonstick. Thickly sprinkle with salt, pepper and paprika, and dot with butter. Bake until just cooked through and skin is crisp (if oven has a convection feature, use it), about 35 minutes.
- Bring a large pot of salted water to a boil. When chicken is done, let cool slightly, then use hands (rubber gloves are helpful) to pull meat and skin from bones, making bite-size pieces. Reserve meat and skin in roasting pan; discard bones.
- Meanwhile, add pasta to boiling water and cook just until tender but not mushy. Reserving 1 cup cooking water, drain pasta and add to roasting pan with chicken meat and skin. Add 1/2 cup pasta cooking water to roasting pan on stovetop and turn heat to low.
- Add rosemary, currants and pine nuts to roasting pan and toss, adding more salt and black pepper to taste, and more cooking water if mixture seems dry. Sprinkle with parsley and serve immediately in shallow bowls.
Yield: 6 servings.


text:
Amazon Is Buying Whole Foods In $13.7B DealThe deal comes a month after Whole Foods announced a board shake-up and cost-cutting plan amid falling sales.
Whole Foods Opens Its Doors In NewarkWhole Foods opened in Newark's redeveloped Hahne's Building on Wednesday.
Ex-Meat Cutter Files $15 Million Suit Against Whole FoodsA former meat cutter at a Whole Foods in Westport is suing the grocery chain for allegedly firing him after he complained to higher-ups that the store was selling tainted meat.
Whole Foods Recalling Specialty Cheese That Could Cause Fatal Food PoisoningWhole Foods is recalling a specialty cheese sold in New York and Florida after discovering the product may cause potentially fatal food poisoning.
Whole Foods Considers Tattoo Parlors To Attract Millennial ShoppersBesides including tattoo parlors, Whole Foods could also add record shops and body care product lines.
Experts: As Consumer Tastes Change Traditional Supermarkets Must Evolve Or PerishThis year marks the 100th birthday of the self-service grocery store, which evolved into the supermarket, but is there anything to celebrate?
Whole Foods Recalls Almost 74,000 Pounds Of Mislabeled PizzaWhole Foods has issued a recall of around 74,000 pounds of frozen pizza for improper labeling.
NJ Whole Foods Store Fires Security Firm That Detained 70-Year-Old WomanRepresentatives from a Whole Foods store in New Jersey say they have fired the security company responsible for detaining and banning a 70-year-old woman.
Police: Woman Arrested For Leaving Infant In Car While Grocery ShoppingThe temperature at the time of the incident was about 84 degrees, officials confirmed.
Suit Claims UPS Charged Customers Different Rates For The Same Sized PackagesAn allegation lodged by the Department of Consumer Affairs claims that Whole Foods mislabeled weights on pre-packaged foods.
Investigation Finds Whole Foods Routinely Overcharged Customers In NYC StoresAn investigation by the city's Department of Consumer Affairs found Whole Foods may be ripping customers off.
Gotham Greens Brings Locally Grown Produce To The Big AppleNew York City usually doesn't evoke images of lush farmland, but one company is looking to change that, and give a whole new meaning to locally grown.


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|Thread Tools
|#1 (permalink)
Intermediate User
Join Date: Dec 2012
Location: SW Missouri
Posts: 44
Puppy vs Cat - HELP!
We have had Jase for 2 weeks. Mostly things are going great except for Jase and 1 of my cats, Zeus. In the beginning they were pals, buddies, now Jase is getting too rough biting Zeus on the back of the neck, pinning him down, stepping on him. Zeus is fighting back, scratching biting his ears (He hasn't bit through his ear, thank goodness) Funny thing is the cat just keeps coming back for more. At the vet Thursday Jase weighed 15.1 lbs at 9 weeks, poor Zeus weighs 11 lbs. I have been pulling Jase off by the scruff of the neck and firmly saying "No Cat!" Well I guess I hurt his feelings a little while ago because he climbed in my lap and started loving on me. Usually he keeps going after the cat when I scold him. Does anyone have any other recommendations? I know to just keep reinforcing but is there anything else? Oh, my other cat just stays high on the cat condo and watches, I'm sure she is laughing inside.
Last night we had to leave Jase for the first time. We are crating him. I have left before, but it was while he was napping and I was back before he woke up. When we got back, some how he had unlatched the bottom latch, pushed open the bottom of the gate and his head was stuck between the gate and the gate facing. It's a wonder he didn't strangle himself. I felt so bad for him. Has anyone had this problem with your dog getting the latches open and if so what did you do?
|#2 (permalink)
BoxerForums Addict
Join Date: Apr 2011
Location: Central Texas
Posts: 2,441
Maggie used to get the latches open on hers but her kennel was made differently. Pheona & Murphy have pawed at the gate but have never gotten them open. Murphy chases our cat (16 yrs old & very grumpy). The cat tends to be faster than her. We keep telling Murphy that Patch doesn't like anyone & doesn't want to be friends. It took till recently that Patch doesn't mind Pheona.
|#3 (permalink)
BoxerForums Addict
Join Date: Sep 2009
Location: south bend indiana
Posts: 2,361
Brandi and the cat are fine Ziggy looks so much like her momma that the cat cant tell she isnt and they are fine Buster and Mia and the cat are ww4 both chase the cat both have had the tarnation scratched out of them I have rescued a very slobbery kitty on more than one occasion now unless the pack is sleeping the cat stays in the basement she comes up and hangs out late at night and until my daughter is up with the Budda and Mia then the cat is gone like a flash you may just need to let them work it out but be sure to give the cat a safe dog free zone
Carol mommy of Roxi aka "rotten" at the bridge RIP sweet girl you are missed, Brandi, Buster and miss Ziggy and occasionally Mia
|#4 (permalink)
Experienced User
Join Date: Oct 2012
Posts: 117
our dogs have a healthy respect for the cats, jase is young and it sounds like he might have to learn the hard way that kitty doesn't want to play rough. as for the crate we found it easier to just baby gate the pups in the kitchen or den while we were gone then to lock them up in a crate that way they can walk around and play.
|#5 (permalink)
Super Moderator
Join Date: Aug 2008
Location: Kawartha Lakes, Ontario
Posts: 6,819
Let the cat teach the puppy what is acceptable behaviour. If the cat keeps coming back for more then they are just rough housing.
Kari ~ Keeper, servant and mommy to the following crew
**Proudly Raw fed since 2009**
|#6 (permalink)
Intermediate User
Join Date: Apr 2010
Location: Saskatchewan, Canada
Posts: 56
If the cat keeps going back for more, they're just playing. Our cat and dog are always play fighting with each other. And when the cat has had enough, he lets her know. Just make sure the cat has some place to go where the dog can't get to in case he wants to be alone or has had enough of the dog. Ziggy isn't allowed down in the basement, so Beavis has the entire basement to himself. Cats can stick up for themselves! Pretty soon you'll have the toughest cat in the neighborhood lol
Ziggy used to get her crate open all the time. She'd wrap her super long tongue around the latches and move them over lol. I'd come home and she'd be curled up on my bed! Maybe just find a way to tie them shut? Depends on the type of crate I guess.
|#7 (permalink)
Intermediate User
Join Date: Dec 2012
Location: SW Missouri
Posts: 44
Thanks for the input everyone. I kind of figured they would work it out someday. I just don't like Jase biting the back of Zeus' neck with those sharp baby teeth. As for the crate, tonight when we went to eat we had 2 small padlocks that we put on the latches. He was still asleep when we got home so I'm still not sure how he will react when he wakes up and we're not home. The crate is a Midwest icrate, so maybe some of you know the latches I'm talking about. We were worried when we bought the crate (before we got Jase) because Zeus decided it was his. There were a few disagreements inside it. lol!
|#8 (permalink)
Power User
Join Date: Dec 2012
Location: New Jersey
Posts: 485
But I still watch them carefully together because now Serena is twice Abby's size & weight, and I don't want Abby to get hurt by accident when they are playing. So far, though, Abby has put Serena in her place. A couple of quick swats & a hiss from Abby usually causes Serena to back off if Abby doesn't want to be bothered. We also have gates up and places Abby can go to in the house which are off-limits to Serena. And Serena is crated at night & when we are not at home.
|#10 (permalink)
BoxerForums Addict
Join Date: Oct 2012
Location: Ontario, Canada
Posts: 6,594
We've had Duke since Sept 21st - he was 16 weeks old when we got him. Our cat HATES Duke. However, our cat is very skittish and runs from every loud sound. Once the cat starts to run, Duke's prey drive kicks in and he chases him like a lunatic. He does NOT listen at all when he's in that state. And the few times that the cat doesn't run from him, Duke will stand there and stomp his front paws until he does run away so that he can chase him. Hubby is scared that one of them will get hurt so we keep them separated for the mostpart. I just don't know what to do... hopefully they will have some pointers for us in training classes when we start on the 20th. I keep telling hubby that we just have to let them go at it and that keeping them separated doesn't help anything! He just says "Wait until the 20th and we'll see what the trainer says." I'm going to rub it in his face when they tell him the same thing I've told him! lol
|Thread Tools


text:
Outlets for a Tennis Court
I am working on a tennis court where the owner wants to add outlets at each of the eight lights to supply as much power as possible for when they use the court for functions other than tennis. They also want the lights off when they are using the outlets.
The court has eight lights divided into two 30 amp 240 volt circuits. The lights are turned on by a single switch that controls a relay with four sets of contacts. The power runs from the panel and the 30 amp breakers to the relay and then splits off to the two end poles on each side. From there wire is run in conduit to the other three poles on each side(one circuit breaker covers one side of the court and the second breaker for the other side).
I know that I can not put an outlet on one leg of the breaker so I think I need to add a sub panel at the first pole with a 20 amp breaker. This would connect to one leg of the 240V 30 A circuit. And do this for each leg of the two 30 amp breakers. There will also be a switch at each pole to disconnect power to the lights.
1) Will this work and be legal?
2) Could I have two 20 amp breakers for each 30 amp leg?
3) What type of panel could I use that would be exposed to the elements?
Thanks for taking the time to read this post.
If you don't know these answers, why are you doing electrical work for someone else?
Have the owner call an electrician.
12 Attachment(s)
People just don't understand the concept of DIY means at your OWN residence.
My question is, is there no thought process of the consequences if someone gets injured or killed?
There is much more to this than you think. 240volt lights means you do not have a neutral for the 120. You need to pull more wires. Might as well pull a proper circuit for the receptacles separate from the lights.
Thanks for the reply's, the owner is my brother and he is helping me out.
I thought there was a neutral because someone previously added outlets to each pole connecting to one leg of the 240. I just checked and they just used the ground for a neutral.
I rather just run proper netural if you going to use the receptales ( this part it much wiser have electrican to assit you on that )
The other issue is that I know some tennis court they will direct bury the UF cable and will be very diffucutally to replace if you have this in conduit it may be a doable depending on the condtion of exsting conduits.
Otherwise you will have to bury a seperated conduit if the oringal one is too small to add a proper circuit.
Thanks for the info, a neutral will be pulled if it can, if not then we quit. How high above the ground does the subpanel need to be and is a grounding rod required?
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Pack 262 Wolf Den Lake Houston Wilderness Park
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What's wrong with it?
It's hard to give advice without all the details.
I have a remington rifle that has sentimental value that the receiver needs refinished but to do this the serial # may be lost what options do i have legally
What's wrong with it?
It's hard to give advice without all the details.
"Government is not the solution to our problem, government is the problem" Ronald Reagan
Here is the ATF ruling on the subject of serial numbers.
I don't see how refinishing it would remove the serial number. Even bead blasting it should leave the SN intact. Could you post a pic?
If it's worn or rusted off, you might see if Remington would restamp the receiver and they would probably reblue it for a fee. I've seen Smith & Wesson do that on a revolver.
Call Remington and ask them about it.
the receiver is so damaged that the pits will need to be filled in possibly causing the serial numbers to be filled in the process. thanks I will contact remington


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Cat Cafe Calico: Securing some me-ow time
1-5-7- Kichijoji Minami Cho, Yuki Building 2F, Musashino-Shi +81 (0) 422 29 8353
11:30am-10:30pm (last entry 10pm)
Cat Cafe Calico, despite breathless reports by foreign media as yet another example of just how kooky Japan is, actually works. It's all part of the recent "cat cafe" trend, and it isn't anywhere nearly as weird as it might first sound.
Cat Cafe Calico is a combo of pet store and coffee shop where visitors pay an entry fee to hang out on low sofas in a room filled with a pack (19, to be exact) of super-people-friendly cats. In a city where space is at an absolute premium, cafes like this are among the only places where many of the chronically cat-less can scratch their itch for feline companionship. And the lattes aren't half bad, either.
The Cat Cafe Calico in Kichijoji is one of two in the chain (the other being located in Shinjuku.) ¥900 gets you an hour with the kitties; every fifteen minutes thereafter run you ¥200 a pop. Those with a need for more quality time can spring for 90, 120, and 180 minute packages.


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TOKYO stocks have risen 1.16 per cent to close at a four-and-a-half-year high after Japan's lower house of parliament approved the government's nominees to lead the central bank.
The benchmark Nikkei 225 index added 141.53 points to 12,381.19 on Thursday, its best finish since September 2008. The Topix index of all first-section shares gained 0.65 per cent, or 6.75 points, to 1,038.17.
Tokyo won support over hopes of further monetary easing steps, as a new Bank of Japan (BoJ) leadership team was approved by the lower house.
Proposed BoJ Governor Haruhiko Kuroda, a finance veteran who has announced his resignation as head of the Asian Development Bank, and his two deputies are widely expected to win upper house confirmation on Friday.
"Confirmation of all of the government's BoJ nominees will send a positive signal that looser central bank monetary policy will be a certainty," said SMBC Nikko Securities general manager of equities, Hiroichi Nishi.
"The overall environment for equities investing remains bullish."
The dollar clawed back most of the losses it suffered in the morning to buy Y96.05 in Tokyo, from Y96.14 in New York, while the euro was at Y124.43 from Y124.56.
All the three nominees are advocates of active monetary easing aimed at dragging Japan out of years of deflation that have crimped personal spending and business investment.
Sentiment was also boosted by revised January industrial production figures that showed factory output rose 0.3 per cent, up from a preliminary figure of 0.1 per cent on-month.
Earlier, better-than-expected US retail sales pushed the Dow to another record close on Wednesday.
In stock trading, major exporters reversed early losses as Sony gained 0.2 per cent to Y1,503, Canon rose 0.57 per cent to Y3,470 and Toyota advanced 0.81 per cent to Y4,950.
Clothing store giant Fast Retailing rose 2.53 per cent to Y30,300.
GS Yuasa, which makes batteries for the grounded Boeing 787 Dreamliner, was down 1.11 per cent at Y442, while All Nippon Airways, a major Dreamliner customer, rose 1.95 per cent to Y209 after US air-safety regulators on Tuesday approved test flights of the grounded plane.
Japan Tobacco shares slipped 2.34 per cent to Y3,130 as the company wraps up a partial sale of the government's stake in the former monopoly, which was expected to raise about $US7.8 billion ($A7.62 billion).
Originally published as Tokyo stocks close 1.16% higher


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Great emphasis is laid on prefixes and suffixes, the origin of words, and pronunciation.
In the following chart the suffixes are constant while the root varies.
We have already seen that Hebrew prefixes its pronominal elements in certain cases, suffixes them in others.
In adjectives we have suffixes of degree (comparison: -er, -est).
Do not trouble to learn the grammar and list of suffixes by themselves first.
As explained above, these suffixes may be piled one on another.
What they left behind them was only six words, most of which became merely the prefixes or the suffixes of the names of places.
The sign of the plural is interposed between the article and the suffixes.
Equivalent to the English suffixes -let in "streamlet," -ule in "globule," "pustule."
These two are the most important and most widely used of all the suffixes.
in the grammatical sense, 1778, from suffix (n.). Related: Suffixed; suffixing.
A letter or a group of letters added to the end of a word to change its meaning. For example, adding the suffix -ter to the adjective hot turns it into the comparative adjective hotter, and adding the suffix -ly to the adjective quick turns it into the adverb quickly. Other examples of words with suffixes are: "willing," "management," "serviceable," "harmonize," and "joyful." (Compare prefix.)


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Accommodation Italy Cinque Terre Hostel 5 Terre Your Review
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Induction blower seal
I just replaced the induction blower on my Trane x80 furnace. The seal between the former blower and the furnace was a very fibrous gasket that essentially disintegrated when I took it out.
I replaced the blower with a Fasco A143, but it didn't come with a gasket or seal. I've seen suggestions of using a bead of silicone around the blower...
How essential is this gasket? Is this something that needs to be fixed ASAP, or can I put it off until the weekend?
Are there any suggestions as to what type of gasket or silicone to use to seal the blower?
Use High temp RTV (like what you would use on a automotive valve cover back in the day) and DO IT TODAY! a 1/2 in bead will be fine.
Thanks for the suggestion. Do they have the high temperature stuff at Home Depot/Lowes?
Presumably, this http://www.google.com/search?q=loc37469 is the stuff you're talking about...
an autoparts store will have high temp rtv as well, like an autozone or napa.
Yep thats it...........
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Sat. October 26, 2013 | Bob Putnam | Email
EAST LAKE — It was a matchup of the two remaining undefeated teams in Pinellas County, a battle between stifling defenses and high-scoring offenses in a game that would determine playoff possibilities in Class 7A, District 9.
But any chance of a tight game ended in the first half.
East Lake continued its dominance over county opponents, jumping to a two-score lead by halftime and pulling away from there in a 42-12 victory over Pinellas Park that clinched the district title.
East Lake (8-0, 4-0) was ahead by more than 35 in the fourth quarter, signaling the use of a running clock. It was the seventh time this season the Eagles have had a running clock.
"Our focus was to try to get ahead by two scores early and keep it a two-score game the rest of the way," East Lake coach Bob Hudson said. "We just wanted to have (Pinellas Park) stay out of their comfort zone."
The script at the start of the game could not have gone any better for the Eagles. After forcing the Patriots (7-1, 3-1) to punt on their opening possession, East Lake turned to its ground game as Weston Fordham ripped off runs of 45 and 23 yards to set up quarterback Jake Hudson's 1-yard plunge for a touchdown to give the Eagles a 7-0 lead.
On Pinellas Park's next possession, quarterback Angel Addison threw an interception to Jake Hansen, who returned it 17 yards for a touchdown to make it 14-0.
The Patriots were unbeaten heading into Friday's game because of a devastating run game that averaged more than 400 yards this season. But Pinellas Park had never had to play from behind or throw the ball more than a few times a game.
Trailing by two scores, the Patriots went to the air. Addison hit Pierre Johnson for 23 and 39 yards, and Johnson finished the drive with a 6-yard run. After a missed extra point, the score was 14-6.
East Lake responded with its run game. Artavis Scott capped a drive with a 19-yard touchdown run to make it 21-6 at the half.
In the third quarter, the Eagles padded their lead to 28-6 when Scott scored again, this time on a 37-yard run.
It only got worse as Devin Abraham returned an interception 15 yards for a touchdown and Fordham scored on a 16-yard run to make 42-6 in the fourth quarter, kicking in the running clock.
The Eagles can put up points in bunches. The stats were pedestrian with just 254 yards of offense, most coming from Scott (107 rushing) and Fordham (111).
But it was the defense that helped with two scores.
"The offense gets a lot of notoriety, but we just go out there and do our job," said Abraham, who recorded his fifth interception and second defensive touchdown of the season. "We're the dark side."
Pinellas Park rounded out the scoring when Kal-el Williams ran 6 yards for a touchdown.


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Coles has been growing grocery sales at a faster rate than
Citigroup analyst Craig Woolford estimates Coles earned just $75 million before interest and tax on liquor sales of $2.8 billion last year. Liquor margins were 2.7 per cent, while overall margins in the food and liquor business were 4.9 per cent. Yet Woolworths earned $450 million on liquor sales of $6.7 billion in 2013, a margin of 6.7 per cent.
Neither Coles nor Woolworths report earnings and margins from liquor, despite growing market pressure for greater transparency given the size of their liquor interests.
While Woolworths's liquor business has gone from strength to strength, fuelled by rapid growth in the Dan Murphy's big-box network, BWS stores and online sales, Citigroup says Coles's liquor business has made no progress.
Woolworths has grown its share of the packaged liquor market from 29 per cent to 48 per cent since 2007, while Coles's share has grown from around 18 per cent to 20 per cent.
A Coles spokesman said much work had been done since the
"The report draws some valid conclusions about the respective sizes of the businesses," the spokesman said.
"But the report is fundamentally flawed in not recognising the changes that have occurred in the liquor business over the last few years."
'Long way to go'
Coles has closed loss-making stores, opened stores in better locations, relaunched the 1st Choice and Vintage Cellars brands, stopped selling deeply discounted beer and strengthened relationships with suppliers.
It has also shaken up senior management, appointing Kevin Rudd's former economic adviser, Andrew Charlton, as general manager last May to take the reins from Tony Leon.
Citigroup says Coles is missing out because its big-box brand, 1st Choice, lacks scale. Coles said 1st Choice was a strong brand, but it was looking at other options such as Liquorland Warehouse. Coles has opened five Liquorland Warehouses and early trials are encouraging, but it has yet to decide whether to roll out the format.
Coles has also been shifting away from stand-alone small-format Liquorland stores in favour of co-locating liquor shops next to supermarkets.
"As [Coles managing director
The Australian Financial Review


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Why? I went there in 1973, during my stay at a kibbutz. I was only 17, so it gave me my first great adventure. I'd just taken my A levels early and been expelled from public school, for insignificant but accumulative events.
The best thing? Cementing my relationship in Sharm el-Sheikh with my first serious girlfriend, a Danish girl.
My ideal day: During the time I was there, I was writing appalling three-chord songs. So in the day, I'd saunter off and play the guitar to myself, which was a blessing to the other people I was with. Then I'd drift back and we'd cook something for dinner on a barbecue before sitting around a fire to sing. That was when they would be forced to listen to my songs about Sharm el-Sheikh.
My advice: It's a sensitive area of the world at the moment, but head to Sharm el-Sheikh if you want to go diving.
Getting there: Cheapflights (cheapflights.co.uk) offers return flights from London to Cairo for around £239pp.
Where was your best holiday? A tour of the Loire Valley, with my wife.
What is the best hotel you have ever stayed in? Le Manoir Aux Quat' Saisons, Oxford (01844 278881, manoir.com, from £225pp pn, including a seven-course dinner).
Where do you want to go next? I would like to go back to south Devon, where we went just a few weeks ago for half term. I'd like to explore the area more fully; it is really beautiful.
What do you never travel without? I write as much as I act, so if I'm working I'll have my laptop. If I am on holiday, I'd pack a supply of T-shirts.


text:
Yes, for the most part
Irish 01
(2005-12-15 11:14:55)
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Question for alum and students...
posted by nicevilleflirish
There are basically 3 groups of football players:
1) Guys you wouldn't know are on the football team b/c their best friends at school aren't on the football team.
2) Players that socialize equally with athletes & non-athletes, but if you run into them they are most likely with other football players.
3) Guys who rarely socialize with non-football players.
In my experience, 75-80% of the players fall into categories 1 & 2. Some guys, for whatever reason, don't care to be part of the regular student body. They typically aren't mean to "regular" students, but it is a shock if you see them with someone other than a football player.
Irish 01
The contents of this post represent the views of the author. NDNation.com is not responsible for its contents.


text: The report also includes opinions from the design and construction community, and reports form their clients mirror the results from the schools and universities directly. 85% of architects report a positive impact on health and well-being from their green school projects, and 85% of them are reflecting student mobility and health concerns into the design of their buildings.The study was produced with the support of the U.S. Green Building Council Center for Green Schools, Lutron, Project Frog and Siemens. Survey and data partners included the Council of Educational Facility Planners International, The American Institute of Architects, Associated General Contractors of America, Green Schools National Network, National Association of Independent Schools, National Building Museum, Society for Colleges and University Planning, and Second Nature. This report is being released with the opening of the new Green Schools exhibition at the National Building Museum ( www.nbm.org). A press preview of the exhibition is scheduled for Thursday, February 28, 2013 from 10 am to noon at the Museum in Washington, DC. To download the full New and Retrofit Green Schools SmartMarket Report, go to http://analyticsstore.construction.com/index.php/new-and-retrofit-green-schools-smartmarket-report-2013.html. About McGraw-Hill Construction: McGraw-Hill Construction's data, analytics, and media businesses—Dodge, Sweets, Architectural Record, GreenSource, and Engineering News-Record— create opportunities for owners, architects, engineers, contractors, building product manufacturers, and distributors to strengthen their market position, size their markets, prioritize prospects, and target and build relationships that will win more business. McGraw-Hill Construction serves more than one million customers through its trends and forecasts, industry news, and leading platform of construction data, benchmarks, and analytics. To learn more, visit www.construction.com. About The McGraw-Hill Companies: McGraw-Hill announced on September 12, 2011, its intention to separate into two companies: McGraw-Hill Financial, a leading provider of content and analytics to global financial markets, and McGraw-Hill Education, a leading education company focused on digital learning and education services worldwide. McGraw-Hill Financial's leading brands include Standard & Poor's Ratings Services, S&P Capital IQ, S&P Dow Jones Indices, J.D. Power and Associates and Platts, a leader in commodities information. With sales of $6.2 billion in 2011, the Corporation has approximately 23,000 employees across more than 280 offices in 40 countries. Additional information is available at http://www.mcgraw-hill.com/. Media Contact: Kathy Malangone, Senior Director, Marketing Communications, McGraw-Hill Construction, +1 212-904-4376, email@example.com SOURCE McGraw-Hill Construction


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speedometer with its own mind????
ok guys I have a problem that just baffles me, hopefully some1 can help me out. the problem is on a 1966 chevy 3/4 ton fleetside with a TH350. the vehicle has a brand new speedometer cable (and well greased), speedometer drive gear can not slip (clip is in place)
ok, well the speedometer works for the most part in the summer when its hot out, however when it starts to get cold she tends to "hang up" I can leave home, with the motor hot, cab cold, get on the highway, floor it, and it still says I am going like 20 MPH when I am going near 60. weird thing is that all of a sudden it will say I am going 90+ mph, just like that, then hang their until I start driving real slow. however if I turn on my heater full bore she does not do it, or at least not very often.
-cable (driveshaft) was greased liberally at installation, no sharp bends, and kept clean.
-its your normal cable driven speedometer with a drag cup connected to the needle. (as stock)
-after having problems with it I took it out, blew all the dust of and checked the needle return spring and its NOT broken
-it has hung up on me in the summer time a cop has even seen it
the only thing I can think of is maybe the magnets magnetism is messed up or a spring thats kinda acting like a spring in a thermostat. since the goofy little thing is so simple I just cant figure out what could go wrong and cause this relationship with cold weather, however not always always in the cold, and the weird needle movements. So are they any gauge guys in here?
thanks for any ideas... 'cuz as this speedometer seams to have its own mind, I think I am loosing mine!
What kind of grease. Usually speedo cables use a dry graphite lube. It sounds to me like the cable is hanging up.
i just saw a new product that was a speedometer that worked of GPS, that would defently solve your problem. i think i saw it on the new Car Craft mag. ill put a link when i find it.
speedometer with its own mind.
Take a small nail & grind 1 end to fit in the speedometer ,put nail in drill & reverse the drill. it will tell you if speedometer works or not...---Take your drill & hook up to 1 end of cable & run your drill & check cable . this works for me.
You have to know how a speedo works. There is no direct connection between the cable and the needle. The cable spins a magnet, inside a cup connected to the needle. The cup and needle are mounted on jeweled bearings. The magnet drags the cup with it against a spring by magnetism only. When it does what you are describing, the jeweled bearings have hardened oil or grease on them, which is making it stick. You can clean out the speedo head, lube the jeweled bearings with light oil, and it will work ok.
thanks guys for your thoughts,
enjenjo, what kind of "light oil" should I use, I have thought about oiling the pivot points, but since I saw no sign of oil I left it as is. you are correct tho, in this model the speedometer needle is NOT connected directly to the cable. this is the typical drag cup design. (some gauges use a flyweight system so it is connected)
anyways, would a fine oil for like a sewing machine work???
The old standby 3 in 1 oil works good.
My '79 Suburban has a similarly lost mind. Reads anywhere between 60 & 95 when going 75 on cruise-control. Where are the bearings that I need to oil?
well you can start out by taking your speedometer back out, I didn't get around to doing it yet, but if you look directly under your needle you will see a small brass looking "bearing" that holds the needle into the speedometer housing. the needle's shaft continues through the bearing where a small calibrated spring is located. the spring is needed so that the drag cup does not peg the needle out. So the quality of this "bearing" must be in good condition. when I took mine apart it looked fine, guess I shoulda oiled it.
bouncing odie
Hi GUYS! My problem is the speedo jumps around all over the place and I was wondering if I need a new head or something??? the odometer doesnt seem to move either????
My 63 suburban was fine for years, then would erractically jump (at 50mph) from 30 to 100. I've got tons of spare parts so I just swapped it out. It is such a pain to pull the cluster out, so I saw no need to torment myself trying to fix that one.
wow i guess i am not the only one with a crazy speedo!
i agree a speedo that is constantly bouncing/jumping has cable problems
btw, the oil trick worked for about a year and a half, then it started acting up again, and now its making a ticking sound and the odometer isnt turning, so a gear in the odometer must be worn out (this 1966 chevy has ALOT of miles, and gets driven over an hour every day year round for many many years...)
Thanks guys for the info and I report back when I get time to pull this thing appart.
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***? Buick cars with Olds engines and vice versa
Okay, it's been a while since i've been on here, cars actually been running fine haha, but tonight one of my friends told me some stuff and I just had to raise my bull**** flag. He tried to tell me that Buick cars come with oldsmobile engines and Oldsmobile cars come with Buick engines. Don't laugh, I argued with him for 30 minutes that either his car has been altered or they let an LD (retard, sorry if it offends anyone) put it together in the factory. Alright so whats the scoup, anyone know any about this? Most of the cars he's talking about are 73-77 Buick Electras and whatever Oldsmobile counterparts. I just don't buy it, he claims that he knows some older factory workers that back him up but its just sounds wrong. I know from my Mustang and my GMC van my dad had a while back that different parts will have different casting numbers sometimes dependant on if it was initially in a Merc or Ford and respectively in a GMC or Bowtie, olds/buick etc. Drop what you think, my opinion is he's been misinformed somewhere..
Last edited by blown69stang; 04-18-2005 at 02:46 AM.
You're friend is 100% correct unless of course they had a Chevy or Pontiac motor. Beginning about '77 GM did all sorts of crossbreeding, there was a little prior to that but in '77 it began in earnest. My stepson had a '78 Buick LeSabre with a factory 307 Olds, countless Trans Ams came with Olds 403's, you name it with Chevy 305s and Pontiac 301's and still other's with Buick 350's and 3.8 V-6's. People actually tried to sue GM when they found out their Buick or Olds had a Chevy motor, they felt they were being "cheated", yeah right. Pick up a copy of a 1980 or so Chilton's manual and scroll through the engine specs on various GM's, you'll be amazed at what came in what. Even as different as some of GM's engines were they were still pretty much bolt-ins, a real testament to the ease of interchange on GM's.
Yup, Hippie is right. My daughter had a '78 Buick with a 307 Olds. When she went off to college I pulled the 307 and put it in my Mazda RX-7.
Always learning...and sharing what I've learned.
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That just sounds ****ing retarded to me. I mean I believe you, but I just can't understand why GM would do that and have differing part numbers and brands on a single car when they could just use a central part code system or atleast recode the parts concurrent with what car they're putting it in. Infact I don't know why, other than for rarity reasons like a shelby or yenko or whatever, that a manufacturer would put two different casting numbers on identical parts just because they happen to go on a different brand car which is identical to another. To me, changing the coding of a part dependant on what brand it goes to even when they're virtually the same car, just makes for more confusion for someone working/assembling a car. I could see where say on a Falcon it would get a different brandline coding for say a set of spindles or something that might be model specific, but like a motor, where a 302w in a cougar is the exact same as a 302w in a mustang, or a 350 in a camaro being the same as a 350 in a firebird, why the wouldnt just put the same numbers on it for simplicity. I could see where trying to combat swap issues on say a boss 429 or a yenko camaro or something like that, but then to go and put a olds numbered part on a buick and vice versa is just retarded in my eyes. Just personal opinion, take it with a grain of salt, I just couldnt believe him when he was telling me this without any proof other than "thats what a guy at autozone told me" or whatever it was.
I have 3 late 70's Buick LeSabres and an Olds Delta 88 that all have Pontiac 301s in them and the kicker is I have a 77 Pontiac Lemans with a 305 Chevy in it.
There was a reason for this, a strike or fire in one of the Canadian plants.It's been covered somewhere else on the board also. Dan
I never heard about the strike/fire, but that makes some sense for short term problems. Of course GM in Canada has always used a lot of "cross breeding" -- had to do with 50s-70s Canadian laws about percentage of vehicle built in Canada (and some other countries, like South Africa).
The primary reason for the corporate engines starting in the late 70s is pure economics. Why have several companies under the same flag building competing engines? Basically engines were spread out amongst the brands (except for Chevy) -- Pontiac got the four cylinder, Buick V-6, Olds kept building the big block 403 (and eventually the ill fated diesel conversion). Caddy kept their own engines as well, but used some Chevy models for a while. Makes better financial sense to do it this way, though I think I'd have spun the engine/trans building off into a separate branch all by itself, then "service" the different body branches from there. That would save even more in the long run, and need not make everything to generic. Different sizes and types could still be made by changing SOME but not ALL parts -- say special OHC or Hemi heads for Caddy's exclusive use, but the same block assembly, maybe even at a reserved displacement (different piston/bore, same crank and rods as others). Lots of things could be done that would be cheaper than 5-6 separate engineering divisions!
As far as interchangeability, you're wrong that "they were still pretty much bolt-ins" Hippie! The factory had to do what every hot rodder does when fitting a different engine in a different body/chassis -- test fit and fab brackets! Only they got to cast or have made really neat looking ones for theirs!!
Yeah, I see your point! Just need to know/research what factory pieces to mix and match now. I was really referring to what the engineers had to do to get it that way, not how easy it is to do now. Sorry for not making that clear!
Ah I see. I never knew that they had different manufacturing sites and distribution for the different brandlines before then. It would make sense to have a central drivetrain division and utilize the factories with each one producing one type of engine, kinda like ford did with theirs. I guess I assumed they had some kind of central division for all that stuff and thats why it threw me off so much. Thanks guys.
I think in the not so distant future you will see GM become much more centralized if they are to survive. Some of the old familiar names will be going the way of Oldsmobile. My guess is Buick will be the next to fade into history possibly followed by Pontiac........ " The times they are a changin' "
Brand survival
Economics and outside competition sure have changed the car business.
It costs about 500 million bucks to engineer and tool up a new engine line that will produce between 250,000 and 500,000 engines a year. That is why even giant GM started sharing engines across divisions in the late 70s. Ford started about 1960. The "divisions" at Ford have been only sales entities since then. The same engineers do everything, the only line is between car and truck, and that only exists at the vehicle system level.
A friend who is a sales executive tells me that its just not economical to maintain a dealership network and advertising presence with less than 3% marketshare, unless you have huge price premiums (think Mercedes, Porsche). That means that every Asian brand except for Honda, Toyota, Nissan (the other big three) is in trouble. He should know, he works for one of the ones in trouble.
Part of the Ford "Premier Auto Group" strategy is to share some of the backroom administrative costs between Jaguar, Land Rover, and Volvo. (Keep different cars and dealers but let the same clerks process paperwork).
Between Pontiac and Buick either one will die, or they will start specializing and further combine dealer bases (e.g. Pontiac will only do small, mid-size, and performance -- Buick will do the higher end) But GM has more money than anyone but Toyota, so it make take some time to force them to that.
The only thing that keeps Ford from killing Mercury is the Lincoln-Mercury dealer body, that would lose product; many cannot dual with Ford because of another Ford dealer down the street. (Ford execs deny that, but have you ever heard a convincing reason?).
Its a painful time in the auto business. If I wasn't close to retirement my resume would be up to date.
Some of this reorganization was due to government interference. There was once a threat to forcibly separate Chevrolet from the rest of GM. GM's response was to funnel all financials through Chevrolet, making it extremely difficult to separate it from the rest.
GM-H ahoy!
Pretty soon you lucky fellers will be finding the Holden V6 under Pontiac and other GM bonnets,and you thought that the Monaro we make over here that becomes a Pontiac GTO over there was bad enough!
The alloy engine is made here in Oz and produced for the world market in three variants with output up to 197 KW. We have been using the Buick V6 in our basic Commodores from 1989 and added the Pontiac Park Lane standard and blown V6es in 1993 with redesigned heads it was called the "ecotec". All commodores are rear wheel drive BTW so a different front housing and sump were made here from alloy to suit. Since 1967 we have used the Chev engine in our Holdens, first the 283 in CKD Impalas and Pontiac Parisiennnes then 307 and 327 in monaros and Broughams then the Gen 1 350 in the Statesman and now the new six bolt mains 350 in high performance Commodores and Monaros.
But if that weren't enough Holden had a deal with Nissan in 1985 - 88 and they stuck NISSAN R31 six cylinder engines into our cars and put "Holden" alloy rocker covers on them if that aint sacrelidge nothin' is !! (Trouble was they were an excellent engine and blew away the old Holden six) D'oh.
cheers from Oz
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Conceals very well Also
This is a discussion on New Holster From LittleBear within the Defensive Carry Holsters & Carry Options forums, part of the Defensive Carry Discussions category; Today i recieved my new holster man this thing looks awsome like a Thanks Dave again I have been Impressed....
Today i recieved my new holster man this thing looks awsome like a Thanks Dave again I have been Impressed.
Conceals very well Also
Nice looking leather...
Proverbs 27:12 says: The prudent see danger and take refuge, but the simple keep going and suffer for it.
Certified Glock Armorer
NRA Life Member
Great looking holster. I've been eyeing these up and think that I will most likely try and get one ordered after I work of spring break.
Indeed, very nice....
Keltec Freak
My Music: www.reverbnation.com/dickiefredericks
yes they do I have been very impressed.
Wow...that's awesome. Again congrats on the beautiful holster.
Very nice my man,really wonderfull looking Leather..
that is just a cool looking holster set. It has got to be comfortable too! Congrats!
Semper Fi
"The gun is the great equalizer... For it is the gun, that allows the meek to repel the monsters; Whom are bigger, stronger and without conscience, prey on those who without one, would surely perish."


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If your floor played football, you wouldn't want it to play without pads, would you? What about playing the game of foot-stomping-on-it-multiple-times-every-day? Well, that's basically what you're doing to your floor without a rug. Feel guilty, and give it padding. Don't you feel guilty? Bet you'd feel better by buying it a rug!
Ends on March 4 at 9AM CT


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Oregon Historical County Records Guide
Sherman County Scenic Images
Downtown Wasco
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Businesses along the main street in Wasco. (Photo No. sheDA0083a)
About this image
Dimensions: 2571 x 3872 pixels (300 dpi version); Date created: June 2010; Camera: Nikon D80 Digital SLR; Lens: Nikon AF-S DX Zoom-Nikkor 18-135mm f/3.5-5.6G IF-ED; Photographer citation: Gary Halvorson, Oregon State Archives; Keywords/Tags: vertical, Oregon, Sherman County, Wasco, downtown, old buildings, architecture, brick, video, variety, druggist, flowers, sidewalk, commerce, business, blue sky, small town, rural.
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Women Writers: Coming of Age at 50
Published: September 4, 1988
(Page 2 of 3)
Two friends from James's youth, Henry Adams and Oliver Wendell Holmes, were, like James, to flower late: Adams did not write ''Mont-Saint-Michel and Chartres'' until he was 65 and his ''Education of Henry Adams'' until he was nearly 70. Holmes was appointed to the Supreme Court when he was 61. Men have seemed able to achieve a life beyond the usual active span. Samuel Butler tells us that Fontenelle, the 18th-century French writer and secretary of the Royal Academy of Science, on being asked at the age of 90 what had been the happiest time of his life, said he did not know that he had ever been much happier than he then was, but that perhaps his best years had been those between the ages of 55 and 75.
Can we find no similar examples among women? May Sarton's fame is greater now that she is 76 than it has ever been. Doris Grumbach became a novelist very late. Stevie Smith wrote: ''I am becoming quite famous in my old age, isn't it funny how things come round?'' Colette came into her own only at the age of 50. The German artist Kathe Kollwitz, when old, wrote in her diary that she found familial ties growing slacker: ''For the last third of life there remains only work. It alone is always stimulating, rejuvenating, exciting and satisfying.''
Fiction has recently dared to delineate a kind of old-age freedom for women. Toni Morrison writes of Pilate in ''Song of Solomon'':
''When she realized what her situation in the world was and would probably always be she threw away every assumption she had learned and began at zero. First off, she cut her hair. That was one thing she didn't want to think about anymore. Then she tackled the problem of trying to decide how she wanted to live and what was valuable to her. When am I happy and when am I sad and what is the difference? What do I need to know to stay alive? What is true in the world? Her mind traveled crooked streets and aimless goat paths, arriving sometimes at profundity, other times at the revelations of a three-year-old. Throughout this fresh, if common, pursuit of knowledge, one conviction crowned her efforts: since death held no terrors for her (she spoke often to the dead), she knew there was nothing to fear.''
Yet, for the rare Toni Morrison portrait, we have many more like this from a novel by Anne Tyler - portraits of women clinging to a life and conditions they have in fact outgrown, instead of launching off into another world. Here is an aged woman from Ms. Tyler's ''Clock Winder'':
''She had once been very pretty. She still was, but now that her children were grown there was something brave about the prettiness. She had started having to work for it. She had to fight the urge to spend her days in comfortable shoes and forget her chinstrap and let herself go. . . . Her face was a series of pouches tenuously joined by transparent skin, reminding her of the tissue-covered frames of model airplanes that her sons used to make. Her close-set blue eyes were divided by minute cracks. Her mouth had bunched in upon itself so that she permanently wore the sulky look she had once had as a child. All she had left was color - pink, white, blond, most of it false. Weekly she went to the hairdresser and returned newly gilded, with her scalp feeling tight as if it were drawing away from her face. She dressed up for everything, even breakfast. She owned no slacks. Her thin, sharp legs were always in ultra-sheer stockings, and her closet was full of those spike-heeled shoes that made her arches ache.''
''Women,'' an Isak Dinesen character says, in contrast, ''when they are old enough to have done with the business of being women, and can let loose their strength, must be the most powerful creatures in the world.''
Yet few women think of old age and power as compatible ideas for them. As the psychoanalyst Frieda Fromm-Reichmann observed, the shock ''is a threshold shock. A door is closing behind us and we turn sorrowfully to watch it close and do not discover, until we are wrenched away, the one opening ahead.'' Most women never discover it, because we cannot believe it is there. Too few of us even ask questions of our old age. Too few of us ask, as Adrienne Rich does: ''Dear Adrienne: / I'm calling you up tonight / as I might call up a friend as I might call up a ghost / to ask what you intend to do / with the rest of your life.'' Ms. Rich can ask this question because she knows ''not all of them will love you whichever way you choose.''
IN the end, the changed life for women will be marked, I feel certain, by laughter. It is the unfailing key to a new kind of life. In films, novels, plays, stories, it is the laughter of women together that is the revealing sign, the spontaneous recognition of insight and love and freedom.
Recently we have begun to notice the perfunctoriness of the endings of Jane Austen's novels. She has had to tie up the ends, to finish her heroines off in the only acceptable way. In the end there is never laughter, but at best contentment, at worst a kind of vague disquiet. Elizabeth, in ''Pride and Prejudice,'' the most romantic of the novels, says of Darcy at the end that he is not yet ready to be laughed at, or with, and there is no woman with whom to share laughter. Austen probably laughed a good deal with her sister and her nieces, but laughter did not mark the high point of any of her adventures or the adventures of her heroines. Women laugh together only in freedom, in the recognition of independence and female bonding.


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King valve as expansion valve...
Hi all! Newbie to the forum and beginner to the topic. I just wanted to get a little discussion and feed back on a cheap (just make it work) method. So here's what I'm working with, this is my single mothers house and she's been living with just window units for four or five years now. She has a 1978 built home with all original equipment with exception to the condenser unit. Split gas furnace with a 3 ton r22 goodman 10seer condenser (replaced around '96) and a rheem coil (orifice tube valve) and the pan is rusted out. Well about six years ago it sprang a leak somewhere, just had it filled once and after the bill my mom said Not doing that again and got the window units. Well after just completing a r410a condenser and evap on my home, my confidence is high. So two weeks ago I figured I would try to swap her system to r134a, put some stop leak in it, change the oil and see what happens. Put it in and I'm getting a 20F split at the closest vent but her run time is 14-15hrs/day with temps over 100F outside 76-78 inside and the inside humidity hangs around 55%. I've adjusted my charge significantly but can't get the humidity down and run times are too long. So here my plan, I'm going to put my old (good condition) 4 ton coil on hers to prevent flood back and use a king valve to vary the flow as needed. All the numbers I'm getting from the system are pointing me to it needs more flow. No evidence of leaks. Have at it, issues, concerns, advise...
General comments
Not quite following the reasoning behind switching to 134a. By using an R-22 compressor and using 134a you are pumping less #'s of refrigerant through the system (vapor density's of refrigerants are different) and also running at significantly lower pressures meaning less refrigerant entering the coil through the metering device.
The downside to just putting more refrigerant into the coil using a manually operated king valve is that you will increase the suction pressure in the evaporator and therefore raise the saturation temperature of the 134a, making the coil warmer instead of cooler. It will also require constant adjustment as the outdoor ambient temp changes. A TXV would be a better option for control of flow to maximize cooling effect and minimize superheat to compressor.
I further wouldn't change to a larger (4ton) coil without the use of a 3 ton TXV, but that being said, why not use your 4 ton coil, put on a 3 ton (R-22) TXV and switch back to the R-22 the system was designed for?
The whole point of the r22 to r134a swap is because I don't have a license handle, so r22 is out of the question for me. Not only that but i've been trying to find a serious discussion on a viable r134a swap for all the diy'ers out there that wont touch a system because they have to have a license... I know it's completely doable but no info really exists that I have found. Anyways so since sticking to the r134a is my only option/ most readily available option, using a r22 txv I dont think is a good idea. I imagine that if I did use an r22 txv with r134a in the system it would keep my temp difference in a very close range to optimum flow but I would probably run into the same problem- just slightly off. So that's why I feel the use of a manually adjustable expansion valve is my best option to optimize my flow rate. I'm completely aware of pressure versus temp issues on in the evap, so I'll just dial back until I'm happy. As far having to adjust the valve due to varying weather conditions, I'm not too worried about that since of course oriffice tubes are fixed metering devices also... I'll just give myself a good safety margin with the superheat and combined with the oversize evap I feel like I'll have a safe and great running setup. Ofcourse thats my take on the idea... What do you think any future prospective buyers or their inspector would say about such a system?
Probably... I'll be finishing up this afternoon, i'll let you know how it goes!
76 inside, 100 outside 55%rh...I don't think I would touch anything. You had a serious stroke of luck..walk away.....
An inspector would say its a Frankenstein system and needs replaced.
R134A in a designed for 22 system will lose a lot of capacity. Probably around 25%. Your mother is probably better off with the window units.
Master of Cold - not with 14 to 15 hr run times per day. That's way too long for my taste...:no:
I've got good new though!!! It's frigging perfect! No leaks, outside temp was 85f and 86% humidity(just rained) and inside started at 78f and 58%. In just 50 min it dropped down to 74f and 48% right where I want it. Maybe with a little more run time the humidity will get down to 42-46% range. Got a 22F split at the closest vent. I left it there for now but I'll check on it tomorrow to check the run times. That king valve takes some fine adjustments but with that high humidity I could make a small adjustment and see the condensation build up on the low side in a matter of two to three seconds. Its quite amazing to have that much contol of the system! :party:
I'll give a run down on the install... Swapped in a 4ton goodman coil and bypassed the existing txv(r22). The only pain in the ass I had was the line set was 3/4 soft copper and the evap had 3/4 hard copper which I was told by a wonderful old man at ace hardware they are measured differently so that's why the same size doesn't fit. Thankfully I found a soft copper 3/4 to 1/2 addapter and a hard copper 3/4 to 1/2 addapter. You would think the 1/2 would be a diifernt size also but they fit perfect. Don't be alarmed by the downsize, the inner diameter of the 1/2 hard copper is nearly a perfect match to the inner diameter of the 3/4 soft copper. Everything else seemed to go together no problem. Little pain on taping up the underside, the whole system just had a very low clearance. Pulled the vacume down to 500 microns, left it there for an hour and half, ended around 600, completly within spec. I had parked the r134a in the condenser, so I just added 3 more ounces of oil and slowly released the refrigerant. I started with the kxv( king expansion valve) closed, after releasing the refrigerant I just opened it up to equalize and then left it barley open. Started the fan first to check for significant air leaks, found minor ones, no big deal. Turned on the condenser, checked my pressures, checked my kxv, let it out until I could feel the low side get cold and the started checking all my numbers and making fine adjustments. Everything is right where it should be, definitely not a compromised system. If anything I would say thing thing outperforms an r22 setup.
There is no size difference between 3/4" soft drawn and 3/4" hard drawn ACR copper. The evap, is not 3/4" ACR, its 7/8" ACR.
Did you drain the old oil from the compressor and put in all new oil so its compatible with R134A?
Substitute Refrigerants and Oils
Refrigerant Blends
The American Society of Heating Refrigeration and Air Conditioning Engineers (ASHRAE) has a specific numbering system (based on the chemical structure) to designate refrigerants. This organization also maintains a list of approved refrigerants and details on their composition and safety on the ashrae.org website.
Refrigerant blends are also numbered according to the ASHRAE system. Blends are comprised of two or more refrigerants that have different physical characteristics. Refrigerant blends that are composed of two different refrigerants are called binary blends. Refrigerant blends that are composed of three different refrigerants are called ternary blends.
Types of Refrigerant Blends
Blends are divided into two classifications, azeotropic or non-azeotropic (also called zeotropic), depending on the temperature glide characteristics of the blend.
Azeotropic Blends
An azeotropic refrigerant mixture acts like a single-component refrigerant over its entire range. Under normal conditions, azeotropic blends do not separate.
Non-Azeotropic or Zeotropic Blends
Like azeotropic blends, non-azeotropic (zeotropic blends) consist of multiple refrigerants blended together. However, a non-azeotropic refrigerant mixture still acts like a mixture of refrigerants after blending and does not behave like a single refrigerant.
These blends cannot be treated like a pure refrigerant during servicing. You can only charge them as a liquid, and when the system has a leak, you cannot top off the refrigerant. The reason you cannot top off non-azeotropic blends is because these blends fractionate during a leak (or during vapor charging). Therefore, the characteristics of the blend change because the more volatile refrigerant boils off in a greater ratio during a leak (or during vapor charging). This dramatically alters the composition and the properties of the refrigerant.
These non-azeotropic refrigerants are given a 400-series ASHRAE refrigeration designation.
Near-Azeotropic Blends
Another informal classification of refrigerant blends is called near-azeotropic. Near-azeotropic blends are non-azeotropic blends that have a very small temperature glide. That is, they change volumetric composition and saturation temperatures in nearly the same way as azeotropic blends. The temperature glide is so small you would not be able to detect it in the field. See the example below where the temperature glide of the non-azeotropic R-410A is only 0.2°F making R-410A a near-azeotropic refrigerant blend.
Although you can treat R-410A and other near-azeotropic refrigerants as an azeotropic refrigerant, most manufacturers recommend that you still charge them as a liquid, but they can be topped off, and this is a significant benefit.
Blended non-azeotropic refrigerants leak from a system in uneven amounts due to different vapor pressures, so these systems cannot be topped off. Instead, you need to recover all of the refrigerant and send it to a reprocessing (reclamation) facility. The system (after repairs) must be recharged using only liquid (not vapor) charging.
The ASHRAE numbering system does simplify things somewhat because you know you can service any 500-series refrigerant like a pure refrigerant without any concern about fractionation. You can charge 500-series azeotropic refrigerants as a liquid or a vapor, and after a leak, you can top off systems containing this type of blended refrigerant.
Charging a Refrigerant Blend
In general, 400-series non-azeotropic blended refrigerants should be charged as a liquid. Because these non-azeotropic refrigerant blends are a mixture of different refrigerants with different volatilities, if you charge them as a vapor, the refrigerant with the highest vapor pressure (most volatile) will be charged into the system at a higher proportion than the other refrigerant components. The only way you can be sure the non-azeotropic blend is charged properly and does not fractionate during charging, is to charge it as a liquid.
Changing to a Different Refrigerant
According to EPA, there are no drop-in service replacements for any refrigerants. The term drop-in replacement means that the refrigerant provides exactly the same cooling, efficiency, pressure ratio, and other performance factors as the original refrigerant with no changes to existing equipment. Despite what some sales materials claim, every replacement refrigerant requires some change to the system. However, some changes are only minor, and the performance differences can be minimal.
Using Synthetic Oils
Ester Oil
The type of oil that is most commonly used in stationary refrigeration applications with HFC refrigerants, such as HFC-134a and HFC-410A, is ester oil. The most common ester oil is polyolester (POE) oil. Although HFC refrigerants are typically compatible with most existing refrigeration and air-conditioning equipment parts, they are not compatible with the mineral oils that were used in a system. Instead of mineral oils, you can use any appropriate synthetic oil.
Do not mix ester-based oils with any other oils except in waste disposal containers. In general you should never mix different types of oils in a system.
All synthetic oils (including POE ester, PVE and PAG oils) are extremely hygroscopic, which means they readily absorb moisture. When working on a system with any synthetic oil, be especially careful not to let excess moisture get into the system. For example, while mineral oil has a water saturation limit of only 25 parts per million (ppm), the new synthetic oils absorb much greater concentrations of water. POE oil has a saturation limit of 2,500 ppm, which is 100 times the limit of mineral oil. PVE has a saturation limit of 6,500 ppm, which is 260 times that of mineral oil, and PAG has a saturation limit of 10,000 ppm, which is 400 times that of mineral oil. With the potential for so much more water in the system, you have to be careful to avoid moisture entry into the system, and you have to rigorously follow triple evacuation methods.
Alkylbenzene and Mineral Oil
For HCFC refrigerant installations and conversions, you can use mineral oil, alkylbenzene (PAG) refrigeration oil, or a combination of the two. Alkylbenzene is a synthetic refrigeration oil and is more expensive, but it can be used with all halocarbon refrigerants. PAG oils cannot tolerate even very small amounts of chlorides, and chlorides can come from coatings in tubing, outdated flushing methods, or residual amounts of CFC refrigerant that might have been in the system.
The synthetic lubricant commonly used with blends containing HCFCs is alkylbenzene.
The synthetic lubricant commonly used with HFC refrigerants and HFC blends is POE ester oils.
I take that back, the adapters I bought were both 3/4 to 1/2 and both of the 3/4 ends were different sizes and the 1/2 ends were the same. I don't know the technicals on copper tubing, I just made sure the matched up properly. I've still got the receipt... :confused1:
Plumbers use inside diameter, refrigeration uses outside diameter.
If you ever get fittings and pipe at a plumbing supply you have to keep this in mind.
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Honors & Awards
University of Miami Neuroscience Research Day, Lois Pope Life Award recipient, University of Miami (2012)
University of Miami Neuroscience Research Day, Lois Pope Life Award recipient, University of Miami (2011)
Scholarship for excellent graduate of East China Normal University, East China Normal University (2001)
Excellent Research Award for undergraduate of East China Normal University, East China Normal University (1999)
Scholarship for excellent undergraduate of East China Normal University, East China Normal University (1998)
Professional Education
Doctor of Philosophy, University of Miami (2013)
Master of Science, East China Normal University (2004)
Bachelor of Science, East China Normal University (2001)
Stanford Advisors
Richard Reimer, Postdoctoral Faculty Sponsor
XU MINGMIN, GUO LIHE, ZANG SHAOYUN, WANG XUESONG, ZHAO GANG,. "China P.Rep. Patent CN101496830B DOPAMINE TRANSPORTER AGONIST AND ITS USE", CELL STAR BIO TECHNOLOGIES COMPANY, Mar 12, 0193
Additional Info
All Publications
Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot
2013; 14 (1): 87-94
Active zones are specialized presynaptic structures critical for neurotransmission. We show that a neuronal maintenance factor, nicotinamide mononucleotide adenylyltransferase (NMNAT), is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein, Bruchpilot (BRP), and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. NMNAT localizes to the peri-active zone and interacts biochemically with BRP in an activity-dependent manner. Loss of NMNAT results in ubiquitination, mislocalization and aggregation of BRP, and subsequent active zone degeneration. We propose that, as a neuronal maintenance factor, NMNAT specifically maintains active zone structure by direct protein-protein interaction.
View details for DOI 10.1038/embor.2012.181
View details for Web of Science ID 000316980300019
View details for PubMedID 23154466
Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model
2008; 29 (5): 603-611
Human amniotic epithelial cells (hAECs), having the characteristics of both embryonic and pluripotent stem cells, have the potential to differentiate into various cells. A good deal of research has explored the clinical therapeutic potential of hAECs; rat amniotic epithelial cells have been reported to ameliorate functional deficits after stroke in rats, likely due to neuronal differentiation and cytokine secretion by these cells. We isolated hAECs and transfected them with glial cell line-derived neurotrophic factor (GDNF) or enhanced green fluorescent protein (EGFP) gene using lentiviral vectors. These cells were then transplanted into the brains of rats subjected to a transient middle cerebral artery occlusion. The hAECs survived and migrated to the ischemic area of rats, and some of the transplanted hAECs expressed the neuronal marker MAP2 and the neuronal progenitor marker Nestin, together with the astrocyte marker glial fibrillary acidic protein, and hAEC-EGFP can significantly ameliorate behavioral dysfunction and reduce infarct volume of ischemic rats. By transfecting the cells with lentiviral vectors, GDNF can be stably overexpressed in hAECs, and hAEC-GDNF can more rapidly rescue the deficits of rats after middle cerebral artery occlusion compared with hAEC-EGFP-treated rats. Moreover, the nontransduced cells also had effects comparable to the GDNF-transduced cells on caspase-3 and lesion volume. Because hAECs are in unlimited supply, and their use is not encumbered by ethical arguments, hAECs have a great advantage for stem cell therapy. This model holds tremendous potential for development into wide use in cell-mediated gene therapy in the future.
View details for DOI 10.1097/SHK.0b013e318157e845
View details for Web of Science ID 000255210900011
View details for PubMedID 18414234
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex.
Brain research
2006; 1073-1074: 131-138
In the auditory cortex, the properties of NMDA receptors depend primarily on the ratio of NR2A and NR2B subunits. NR2B subunit expression is high at the beginning of critical period and lower in adulthood. Because NMDA receptors are crucial in triggering long-term potentiation (LTP) and long-term depression, developmental or experience-dependent modification of NMDAR subunit composition is likely to influence synaptic plasticity. To examine how NMDA subunit change during postnatal development affect the adult synaptic plasticity, we employed chronic ifenprodil blockade of NR2B subunits and analyzed evoked field potentials in adult C57BL/6 mice auditory cortex (AC). We found that chronic loss of NR2B activity led to a decline in LTP magnitude in the AC of adult mice. Adding NMDA to the artificial cerebrospinal fluid (ACSF) in blocked mice had the opposite effect, producing LTP magnitudes at or exceeding those found in treated or untreated animals. These results suggest that, even in adulthood when NR2B expression is downregulated, these receptor subunits play an important role in experience-dependent plasticity of mouse auditory cortex. Blockade from P60 did not result in any decrease of LTP amplitude, suggesting that chronic block in postnatal period may permanently affect cortical circuits so that they cannot produce significant LTP in adulthood.
View details for PubMedID 16457785