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General Motors Decides to Err on the Side of Too Many RecallsBy
At this point, General Motors is just driving in the proverbial breakdown lane with its hazard lights on. The company recalled another 2.7 million vehicles on Thursday for a range of potential defects and took a charge of up to $200 million to cover the repair costs.
The move is classic crisis-control strategy: take the lumps quickly and decisively, so things can move forward. If you think of GM as a scandal-tarred politician, the company would be standing in front of a wall of cameras naming all of its mistresses and back-room dealings. Basically, the automaker is trying to avoid a prolonged Anthony Weiner-style circus.
GM has recalled 11.1 million vehicles in the U.S this year, and it has sold 904,000 new vehicles. "These are examples of our focus to surface issues quickly and promptly take necessary actions in the best interest of our customers," Jeff Boyer, GM's safety czar, said in a statement.
But the latest round of recalls is remarkably broad and it captures some of the company's most celebrated models. Sure, GM is mostly welcoming back into the shop 2004 to 2012 Chevrolet Malibus. But it is also recalling 19,225 of its current Cadillac CTS sedans, Motor Trend's "Car of the Year," as well as some 500 contemporary Silverado and Sierra pickups and 112,000 Corvettes from 2005 to 2007.
Even though many of the potential defects seem valid and dangerous, GM is apparently erring well to the side of caution with its sweeping response. Take the purported issue on the Cadillacs: GM says the windshield wipers could stop working after a jump-start and when they are gummed up by ice and snow—that eems like a fairly specific set of conditions. The Corvettes, meanwhile, may have an issue with their low-beam headlights.
Safety is good, but entropy is a law of nature. Eventually everything breaks down—and giant pickups sold in Texas are no exception. When a carmaker issues a formal consumer warning, in many cases the repair can be largely a judgment call in a sort of amorphous risk/reward equation.
In GM's current crop of recalls, the company seems to be betting the conservative course—safety overkill—is more prudent than any further dents to its reliability. If recent sales are any measure, that line of thinking is sound. Last month, when GM CEO Mary Barra was suffering through congressional hearings, U.S. drivers bought 7 percent more GM vehicles than they did in April 2013.
One-time expenses aside, recalls seem to be without risk for GM. Avoiding them, meanwhile, has certainly proven a more fraught path in the past.


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If you are a poetry lover, then you're sure to appreciate these poems about love, poems about life, poems about loss, and faith, and redemption — all delivered in simple, yet achingly beautiful, words. My poetry tends towards the inspirational. I often don't know what a poem is about until I find it coming together on the page. I just feel the itch that says, this one's a poem, not a story. I first publish my poems in pamphlets that I call Ten Thoughts About Love with yes, ten poems in each (except for Vol III, which includes haiku, so I put some extra in, as they are so short.) I write haiku daily specifically as a way to generate creative presence. I've lately started posting them with pictures on my Instagram. I also rather loosely translate old Irish blessings. Each collection of ten usually has a blessing poem in it. Blessing is an art in itself; we still do it (Have a nice day!) but we've forgotten what it is and what it's about. For me, a poem is a key, unlocking a moment and revealing the infinite well of possibilities that i, and every moment, contains..
Want a sample? Listen to some poems.

subset: commoncrawl


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- 16 total posts
- 14 comments
- 2 questions
Questions from jamit30
More Wrinkles After Botox
I had Botox injected on the sides of my nose. Now, when I smile, I have way more wrinkles under my eyes when I smile. Is there anything I can do to interject those wrinkles? READ MORE
Puffy Eyes and Wrinkles After Botox Under Eyes
I recently had Botox injected on the sides of my nose, which caused SERIOUS wrinkling under my eyes when I smiled. I looked 20 years older. I went back and they put a small... READ MORE
Recent comments from jamit30
HI, I took photos everyday, but they were erased when someone updated my computer. I wish I could send them to you. It DOES get better. It takes awhile - you just have to be patient. I understand about not wanting to looking... READ COMMENT
Oh no - I had a droopy eye, crazy wrinkle, dark bags, vertical wrinkly on eye lids. It was soooo bad. I understand how you are feeling. I am finally feeling and looking better. I still do not smile the same in pictures, but I... READ COMMENT
Thank you ladies for listening. Whenever I went to laugh at the shower, I always looked down in hope no one would see my scary face! :o) I'm feeling better today. Looking forward to my 6 week mark. Coming up on my 4th on Tuesday... READ COMMENT
Boy as time goes boy the more I see thngs that are wrong with my face. I really think when she injected it on the side of my nose it goofed everything up. On my right side it looks like I had a stroke. Everything is off - my eye... READ COMMENT
Your right Amy - I cancelled my appt.....I need to wait it out and have to think I will be 10% better next week, right? :o) Will your botox be diminished by your wedding? READ COMMENT


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So an idea I've had while browsing through the Forza Race Night's topic was to bring a similar idea to the Minecrafters on GB. The idea being once a week everyone gets together on a server, and are tasked with building a particularly themed building/thing within either a very loose time limit or just until everyone leaves for the night. We can have it happen for both 360 players and those on PC/Mac. Of course whoever runs the PC side would need a server to run things on, and I think it can be left up to those involved wither the game would be set to peaceful or not.
I was thinking too of giving it a name like "This Old Minecraft" or something like that.
Comments, thoughts, yelling at me for having stupid fucking ideas?


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About company
We are a leading and pioneering enterprise with the most advanced international level in R&D, manufacturing and selling of large-scale crushing & screening plants , industrial milling equipments and beneficiation plants. All of our equipment have got ISO international quality system certification, European Union CE certification and Russian GOST certification.The company mainly manufactures mobile crushers, stationary crushers, sand-making machines, grinding mills and complete plants that are widely used in mining, construction, highway, bridge, coal, chemical, metallurgy, refractory matter, etc. Product quality is life, and scientific innovation is motive power.


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Warner Bros.' Jonah Hex is rolling as we speak, and today the first batch of candid behind-the-scenes images of Megan Fox have hit the web. Megan, Megan, Megan! What we would do for a peek under that bathrobe!
Megan Fox will be playing Leila, a gun-wielding beauty and love interest of Hex (Josh Brolin), a scarred bounty hunter tracking a voodoo practitioner (John Malkovich) who wants to raise an army of undead to liberate the South.
Click on the image below to see them all!
Got news? Click here to submit it!
Forget about stuff in the Dread Central forums!


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CC-BY vs CC-BY-SA and How to Define Open Content
As an open source and open content advocate, I am interested in the debates in the OER community about licensing, particularly CC-BY (attribution only) vs. CC-BY-SA (attribution and share alike). To admit my bias, I am, and have always been, a copyleft advocate, so I'm a card carrying member of that latter group of those that believe in share alike.
Now, there are certainly many good reasons to choose either license depending on one's priorities in license choice. Nevertheless, I always chuckle when the CC-BY advocates condemn CC-BY-SA while championing that CC-BY allows for users to make choices about licenses they wish to use, whereas CC-BY-SA doesn't allow for licence choice. As Sam Varghese pointed out during a resurgence of a similar debate (2007) in the open source community between the GPL and BSD people,
Curiously, the BSD people, who have no objection to their code being locked up for good in proprietary applications, raise hell when someone uses the GPL instead. Why? The only thing that the GPL ensures is that any code released under it will be free thereafter.
While some CC-BY advocates may indeed believe in privileging private commercialization of IP in opposition to Share Alike, I believe that many instead are not a fan of proprietization of their work, and what is unsaid but implied in their license choice is the following:
if you use and remix my CC-BY content, you have the right to choose how to relicense the work however you see fit, but you really should choose to relicense derivative versions under CC-BY.
How similar this is to the parent who gives a teenager twenty bucks, telling her "she can use it however she wants," when the teenager knows what the parent really means is in a responsible manner that the parent would approve of. If this hidden implication is the case for some content creators, then authors might consider getting off the fence and choosing the license which accomplishes what they really want.
What stimulated this thinking today about licensing was David Wiley's condemnation of Open Knowledge Foundation declaration that SA is more open than content with the Noncommercial (NC) clause. Now, David, in claiming ownership of the definition of "open content" because he coined the term, points to his 2004 definition Defining the "Open" in Open Content. I can partially agree with him. I think it's difficult to define SA as more open than NC when interoperability is a constraint.
However, I don't agree with Wiley's current definition of open content, but rather with the somewhat different implied definition of "open content" in Wiley's OpenContent License (1998) and Open Publication License (1999) (see the 2003 version of these web texts in the Internet Archive) back when he came up with open content. The OCL is a copyleft license very similar to CC-BY-SA, and the OPL is similar to CC-BY. Thus, it would seem that Wiley might have originally thought that CC-BY style licenses were not open content, and that open content is equivalent to copyleft (or, at least, that CC-BY-SA is "more" open). As Rob Meyers has previously written (and as most FOSS advocates would agree), adding noncommerical restritctions to a copyleft license makes it no longer copyleft. Thus, IMHO, NC licensed content would be seen as not truly open content from this perspective.
Regardless, these two fundamental principles, whether openness depends on interoperability or continued openness of the derivative works, cannot be reconciled in one license, and I doubt it would be possible to generate OER community agreement on one priority over the other. Better would be to develop an open content definition much like the Open Source Definition at OSI which does not privilege either of these principles, and in doing so, OSI avoided creating a riff in the open source communinity over over whether or not the GPL is more open source than BSD, or vice versa. Given these considerations, the OKD works well for an open content definition.
Update 6/29/2010: David Wiley has a post up indicating that he did feel that CC-BY/BSD style licenses worked better than his original, copyleft Open Content License.
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filler over lead
Is it true you should seal it off with epoxy before filling? I heard this today by a good lad named Jamesfreddy(youtube chan). I never had problems with filler sticking to lead but would love to hear your thoughts.
What is generally accepted these days is to strip to bare metal and seal with 2 wet coats of epoxy then carry on with filing and blocking steps..if one encounters lead in good condition just epoxy over that as well and carry on..that is what I would do..
so in general you are saying epoxy over lead as a seal coat before adding filler on top to perfect it? This is interesting to me cause that now means I'll strip those areas before it goes to the stripper so I can block out the lead. This way when I get it back in epoxy I can just lightly sand and fill without worrying about the shape of the lead. I'm generally talking quarter seam lead.
Doing it that way is a real time saver and works fine..I am in favor of getting all the parts and pieces cleaned and in epoxy primer as I go so when the car is re-assembled all that needs to be done is to scuff the epoxy and carry on with the blocking a painting..
yeah, and a rough out of the metal you can see as well. Sounds like a plan. Thanks.
I still gotta ask, have you had issues with putting body filler straight over lead? Sorry for all the prodding. :D
I have had no issues and I am sure hundreds of cars had filler direct to lead with no issues over the years..so not to worry if you have done some that way..
just checking, cause he himself said he had no issues doing it thru his own experience but will epoxy over lead cause someone he trusts told him so. I dunno, I do notice on rare occasions that it won't feather great on the lead and it will chip away but it was one out of hundreds. Thanks for the input, guys.
I've been putting filler over leaded seams since 1972 with no failures.
I have had trouble putting filler over lead on one car inparticular and WILL always seal with epoxy from that point on. Had to completely redo 12 spots on a 56 tbird that all blistered in the lead areas. Talked with several people about this and they all recommended to seal over original leaded seams before skimming with filler. Apparently lead oxidises almost immediatly after sanding it, so what I do is put some epoxy in the gun and have some 180 grit in the other hand then epoxy as soon as I scuff it up. I have put filler right over the top of lead years and years ago with no trouble, but when you do have trouble beleive me fixing that bird was total hell. Car was completely finished fresh from the restoration shop that had to reassemble it. That is when it came back to me to "fix" all the blisters. Had to take half the car apart, grind all 12 spots back down to the lead (all tough compound curved areas) then redo all the bodywork then proceed to blend in all these spots. It was a nightmare plain and simple and because of that I always first epoxy the lead regardless.
Lead had been a major headache for restoration shops for years, this is why so many grind the lead out and refill with different types of fiberglass fillers, witch I think is just an abomination.
First mistake, is cleaning the old lead with lacquer thinner, first of all lacquer thinner today is not lacquer thinner unless you have a $100 + a gallon thinner from one of the majors.
Now the exception is new lead you applied, then yes it should be neutralized but use a fast urethane reducer would be your best bet.
Buzz the lead with a DA and 80 or 180, just to clean the top and smooth out, never touch the lead with a 2K primer, Body filler, fiberglass or glazing putty.
Clean the lead with a good grade wax and grease remover and then do it again, let set overnight.(very important)
Apply one wet coat of epoxy that is activated only, no extra reducer should be added. (very important)
Let set at least an hour at 70-75 degrees, (very important) spray a second wet coat.
Let set 24-48 hours at 70 degrees or higher, then any low spot or chips finish out with your two part glazing putty using the epoxy as a barrier coat.
This is as bullet proof as you can get and as 4speed said, no car is more loaded with lead then a 55-57 T-bird.
awesome responses and looks like I'm not the only one who learned something here. Thanks, guys.
Even if spreading filler over the lead "could" work and has many times, the time spent to do it RIGHT and put the epoxy over it sure isn't time wasted that's for sure! :thumbup:
my take is this, guys have stated they have done it with no problems at all. In fact, I'd say most people do it this way, and I haven't heard of issues, but the fact that a few other reputable people have had isses with it, that's enough for me to err on the safe side. Thing is, we all can't do what we really want in a work atmosphere on every job.
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Nowadays the city is known for its affluence, modernity and nightlife, and life as a Shanghai intern will give you a taste of Eastern glamour few cities can rival.
The following programs are available in Shanghai:
- China Internship Program
- China Internship + Travel Program
- Chinese Language Program
- Chinese Language + Internship Program
- Study Abroad Program
Our China Internship Program in Shanghai is tailored to enhance both your professional and personal development, by offering placements in a range of different internship sectors, including Finance, Accounting, Business, Marketing, Engineering, Legal and many other industries.
Home to China's largest stock exchange, and the new Free Trade Zone, Shanghai is a hub for finance and entrepreneurial business ventures and is one of the most affluent and expensive cities in China. As part of the China Business & Finance Course, you have the chance to spend a week in the government and business heart of China, Beijing, followed by a week in Shanghai, learning about China's economic complexities, business regulations and financial markets.
As Shanghai's people become richer, they engage in one main pastime. Shopping. The consumer culture in Shanghai is extensive and entertaining, with traditional markets and modern malls to cater to every whim. Check out the Flower, Bird, Fish and Insect market to see old Chinese men barter for caged crickets, or the hi-tech Cybermart to pick up every imaginable piece of electronic equipment.
This consumer frenzy has pulled in people from around the globe looking for business opportunities, and has spawned a unique sense of entrepreneurship in Shanghai. New, exciting businesses try their luck here everyday as success in Shanghai can be the starting point of a bright and plentiful future. Many expats have flocked to Shanghai over the past few decades, making it one of the most competitive Chinese cities to enter the job market as a foreigner.
Students nowadays tend to seek international internships rather than in their home country as there are many benefits in doing so. An internship is a unique way of enhancing your professional experience in a field of your choice, with the added benefits of networking with international students and experiencing a whole new culture.
The internship program runs every month all year round and is designed for current university students, recent graduates or people looking for a career change, to gain professional work and life experience in China's burgeoning economy, thus placing themselves on a competitive edge in the job market.
For more images of Shanghai, including accommodation, events and intern travel, please visit our Photo Gallery.
Life in Shanghai as an Intern
Located on the Yangtze River Delta, Shanghai has grown from a traditional trading port to a truly global and progressive city. Its history as a harbour city has meant that Shanghai has always been open to international influences and at the forefront of Chinese modernization.
One of Shanghai's most famed features is its skyline. Architectural wonders past and present populate the Western bank of the Huangpu River, known as The Bund. Lit up at night it is a striking mix of Art-Deco architecture and older gothic and baroque buildings. The city is a cosmopolitan metropolis and buzzes with life, day and night.
The mystical City of God Temple lies at the core of the old city and reveals a more ancient Chinese past, where many go to pay their respects to the gods and the Taoist priests who reside there. Here, the Chinese heart of the city can be seen in the buildings and the historical monuments.
Life as a Shanghai intern is fast-paced, gilt-edged and absorbing – when you're not working in the heart of China's commercial center you can relax in glamorous bars and clubs, take advantage of the abundant shopping opportunities, or sample the delicious specialties associated with Shanghainese cuisine.
Your Internship in Shanghai with CRCC Asia will include international quality accommodation, various social and networking events, 24/7 support and Chinese Mandarin lessons.
We maintain close contact with our Shanghai Internship Program participants after they finish the program as part of our Alumni Network. We'd recommend reading more about their experiences with the program on our Testimonials & Media page.
For information about Shanghai and China in general, including information about Chinese currency, working in China, getting around, and the Chinese language please visit our China Travel Guide, written by previous program participants.


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06.10.2011 •
Events NEWS
The models in Sophie Delaporte's Nudes series merely dispose of a few simple accessories, paper, some textiles, a chair. That is enough for her to create those very special moments.
In the introduction to the catalogue that accompanies the exhibition, Vicki Goldberg explains "Delaporte sings a body electric: current and quick, seldom static, hardly shocking, charged with energy, and crackling with unpredictable incidents. Seductive in an unlikely fashion, this series of capricious nudes cavorts across an uncommonly witty body of work...
At times the nude before us covers her face with a bunched-up dress while the parts of the body that are generally concealed remain on conspicuous display. Though this might not be your idea of how to decide if a dress will attract a lover (but it certainly ought to work), it definitely looks like a good time. I'd say it all looks like a good time –for the model, for those wayward clothes, and no doubt for the photographer. Me too."
Born in Paris in 1971, Sophie studied Photography and Film at the Louis Lumière school in Paris.
Nudes - Sophie Dealporte
Sous Les Etoiles Gallery, New York


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Alfani Double-Strap Printed Chemise, Only at Vogily
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text:
From BPMN Process Models to BPEL Web Services
Ouyang, Chun, Dumas, Marlon, ter Hofstede, Arthur H.M., & van der Aalst, Wil M.P. (2006) From BPMN Process Models to BPEL Web Services. In 2006 IEEE International Conference on Web Services (ICWS'06), 18 - 22 September, Chicago, USA.
|PDF (232kB)
The Business Process Modelling Notation (BPMN) is a graph-oriented language in which control and action nodes can be connected almost arbitrarily. It is supported by various modelling tools but so far no systems can directly execute BPMN models. The Business Process Execution Language for Web Services (BPEL) on the other hand is a mainly block-structured language supported by several execution platforms. In the current setting, mapping BPMN models to BPEL code is a necessary step towards unified and standards-based business process development environments. It turns out that this mapping is challenging from a scientific viewpoint as BPMN and BPEL represent two fundamentally different classes of languages. Existing methods for mapping BPMN to BPEL impose limitations on the structure of the source model. This paper proposes a technique that overcomes these limitations. Beyond its direct relevance in the context of BPMN and BPEL, this technique addresses difficult problems that arise generally when translating between flow-based languages with parallelism.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
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Full-text downloads displays the total number of times this work's files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
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|Conference Paper
|business process modelling, Web services, BPMN, BPEL
|Past > QUT Faculties & Divisions > Faculty of Science and Technology
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|Copyright 2006 IEEE
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|Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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|18 Dec 2006 00:00
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|21 Jun 2017 14:39
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Originally Posted by Mistletoe
I wish Thanksgiving were warmer (we're in the 30's or 40's at that point, I believe). Actually, I wish our Thanksgiving was at the same time as Canada's- in October. I would love to eat outside at a long table with the leaves changing colors around me. Like it probably was at the first Thanksgiving.
Thats funny because for my ideal Thanksgiving I am sitting inside a huge home with a fire roaring and snow falling outside (it may be too early for snow in Nov, but I can dream!) and my family sitting around a large table laughing and passing around the food. We usually sit outside in the heat because our family is so freakin' huge :-)
Last edited by MacShirts; 08-08-2009 at 01:45 AM.
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Correct & complete OEM aux Retrofit install
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Mein Auto: 2006 750i E65
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Thanks Paper
the volume line does not pop up when i presss the aux 2 times or a few times. it stays white which tells me the ASK is not switching to aux.
the plug that is in the aux spot goes back to the same thick cable that comes from the other ASK plug (the main plug). they combine into one thick wrap which tells me it was done in the factory? but how can that be?
i checked the center console and the glove box but no aux plug. my car is 01/06 E65 so i dont think the aux was availble from the factory on that model
how do i change the mmi back to factory settings? the only thing i changed in it (other than the aux parameter) is the legal disclaimer time out.
i saw posts of people that enabled the aux on pre facelift ASK so it should work on mine as well (post facelift)
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Pereira started the year in San Jose, where he played from Opening Day to the middle of June. In thirteen starts there he amassed a record of 7-1 with an ERA at 2.06, and his strikeouts-to-walks ration remained obscene at 76 to 16. For his efforts in the California League he was named to the Cal/Carolina All-Star Roster, and San Francisco's brass sat up and took notice of what their 2005 10th round pick was doing when they chose him to represent the organization at the All-Star Futures Game in Pittsburgh next month.
Pereira's road took a turn north when he was called up to AAA Fresno on June 18th. He started his first game at the highest level of the minors in Portland, first considered as an injury call-up. With about two weeks with the Grizzlies Pereira's numbers have come down to earth from his early season dominating figures, one win to one loss and an ERA just under 6.00 with nine strikeouts in three starts, but growth is more about making mistakes than just blowing people away.
He has to be doing something right to be recognized by the All-Star Futures Game selection, and to watch him in person is to see just how far he has come. Consider Pereira's history as a baseball player; this is a young hurler who was drafted just one year ago, who began pitching in his freshman year of college. His changeup has been a work in progress since the beginning of the season, and Thursday night in a start against the Sacramento Rivercats he had that off-speed stuff working. He struck out two Rivercats hitters with well-placed changeups, one swinging and one caught looking.
Over five and two thirds innings, Pereira went to three-ball counts five times. His command was neither outstanding nor cause for concern, and his outing wasn't terrible at all despite taking the loss. Progress is made through these kinds of starts, games where a young pitcher has the chance to work out of jams, and pitch with a deficit to keep the team in it. In the start in Sacramento, Pereira did just that.
Take a look at his counterpart in that start: Jason Windsor is a highly-rated prospect in the Oakland Athletics system who is having a great year with Sacramento after a call up from AA Midland. He had the Grizzlies swinging at everything he had to offer and collected ten strikeouts, but his command looked worse than Pereira's; more walks and just more pitches out of the zone, yet fewer hits allowed. But that's the minor leagues. Raw talent and perplexing outcomes, unexpected performances and things that aren't easily explained. By now, Giants fans should be used to this.
The discrepancy in Pereira's stats from San Jose to Fresno is the difference between high-A and AAA, as well as an excellent team (San Jose) and a bad team (Fresno). Of course some marks on a pitcher's record are solely his responsibility, but having a great team behind him in San Jose had to have helped. The highest level of minor league ball is the biggest test Pereira has had to face, and there's talk that he might remain with Fresno beyond his time filling in a roster spot.
What is left for him to learn in San Jose is less than what he can experience in Fresno, and he's earned accomplishments that define his talent. He's at the junction of his career where he needs to grow more than he needs to collect flashy statistics. He was not drafted to be the Man, and with reasonable expectations and the appreciation for what he can do, Nick Pereira will turn out to be a fine addition to the pitching staff at any level. Hopefully soon he'll have a chance to prove it by the shores of McCovey Cove.
Chris has been a Giants fan since her days in utero. She loves baseball and writes about whatever she can get her hands on…even the Athletics. She's a Bay Area gal through and through. This is her 24th season of fandom and first where she's had the honor to write for the Giants on SFDugout.com. Love/hate mail can be sent to email@example.com, where the love mail gets top priority and the hate mail gets used for kindling.
The views expressed in the columns do not necessarily reflect the opinions of the site's publisher, writers, or other staff members. The content on this site may not be redistributed without the expressed consent of SFDugout.com.


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Pie weighs optionsMichael Gleeson
Published: October 4 2012 - 3:00AM
THE choice for Collingwood forward Chris Dawes would appear to be to stay put or move down Swan Street to Melbourne next season.
The Demons are keen on securing the power forward, who agreed yesterday with his club that he would canvas the prospect of a move after the Magpies recruited Quinten Lynch this week to play the position he had played this season.
Dawes met coach Nathan Buckley yesterday to discuss the ramifications of Lynch's signing. The pair resolved at that meeting that the forward would consider offers from other clubs. Melbourne has already expressed strong interest in Dawes, who played under Demons coach Mark Neeld when he was an assistant coach at Collingwood.
''He is one that we are interested in,'' Demons football manager Tim Harrington told SEN radio yesterday. ''There's quite a range of tall types who we've made inquiries about. We're just watching what's unfolding at Collingwood so that we can make some sort of assessment of whether he's for us.''
The Western Bulldogs had asked about Dawes's status in recent weeks, while Carlton, Richmond and St Kilda all said yesterday they would not pursue him.
Dawes has two years to run on his contract so any move would happen only if he and Collingwood were satisfied with the terms.
Dawes is studying law in Melbourne and is not interested in an interstate move. His manager, Ben Niall, said his client was happy at Collingwood but the dynamic had changed slightly with Lynch's arrival, prompting him to consider his options.
It would appear that Collingwood intends to play Travis Cloke and Lynch as the first-choice two tall forwards next year and Dawes would have to work to find a position in the structure.
This story was found at: http://www.smh.com.au/rugby-league/league-news/pie-weighs-options-20121003-26zsf.html


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Ranking with Google Plus
Post by Ray 5 years ago - Google Plus - 2 Comments
Everyone who has a business, whether they're self-employed or run a chain of restaurants, wants to be found.
That is unless their business involves the cultivation of a certain herb or the laundering of items other than laundry.
Who doesn't want to rank on top of that Google search results page?
After all, Google does owns the top two search engines in the world: GOOGLE and YouTube
Networking through "Circles"
Google+ "About" pages contain a lot of information that will enable you to expand your personal and business network. With the information provided, you're able to put the contacts in circles according to labels that reflect interests, expertise, prospects, IRL (real life contacts), geography etc.
Making your "About" page keyword rich and descriptive will also help Google and other "plussers" find you.
(For more on circles & G+, check this video: What is Google+ (Google Plus) and do I need it? )
Lead Generation & Nurturing
Because of its SEO advantage and uncluttered share-friendly platform, Google+ is a prime lead generator.
Like other social media, it should be treated as an outpost, not your home base. Your base is where people will do business with you. Your outposts is where you network and develop relationships.
As Mari Smith says:
We're not B2C or B2B anymore, we're P2P – People to People. (cue Barbara song)
Through interaction; commenting and sharing on other's posts, you can increase the number of people who follow (circle) you in a relatively short time.
Keep in mind that you should have a strategy for who you circle as that can influence your Google search results when logged into Google+.
Optimize your Google+ posts for SEO
Not being an SEO specialist, I've inserted Cyrus Shepard's 6 point list that illustrates Google's SEO strategy for Google+.
1. Incentivize Inbound Links
Google started displaying author photos in its search results. In order to display a photo, Google asks authors to add links from their webpages to their Google+ profile.
Google's SEO Tactic: Require Authors to Link to their Google+ Profile
2. Internal Linking
One thing noted about Google+ when it was released was just how easy it was to be in lots of circles, or add lots of people to your own. People who struggled on Twitter for years to build up 1000 followers, suddenly found themselves in 2000 or 3000 Google+ circles, seemingly overnight.
Google's strategy to connect everyone on the planet also makes for good internal linking. Following more than 1000 people may not create a practical social experience, but it creates a great SEO opportunity. The more your content is shared in other people's streams and profiles, then the more your content is crawled, indexed, and deemed important by search engines.
Google's SEO Tactic: Encourage Large Circles Counts
3. Lots of Indexable Content
Google structures content to provide a wealth of information for search engines, to index and serve in search results. Compare: Facebook – 275 Words, Twitter – 491 Words, Google+ – 2621 Words
My public Google+ profile contains a wealth of information, all visible to search engines, including:
- Biographical Information
- Full Text of Public Posts
- Photos
- Links to people who have added me to their circles
- Everything I have ever +1'd
Google's SEO Tactic: Search Engine Friendly Profiles
4. On-Page Optimization
Google+ makes it easy to share posts from others – a feature much like retweeting on Twitter or reblogging on Tumblr. These Google+ posts frequently show up in search results as their own entries. Also, Google wisely choose longer, more descriptive title tags.
Google's SEO Tactic: Descriptive Title Tags
5. User Generated Content
Every public post is crawled and indexed by Google search. The privacy settings on the profiles are simple, intuitive and encourage openness…Facebook, in contrast, only shares posts from fan pages with Google, and not posts from regular profiles.
Google's SEO Tactic: Encourage Public Sharing
6. Show Google+ Author Profiles in Search Results
This demonstrates the power of rich snippets.
Google's SEO Tactic: Creative Rich Snippets
Not convinced?
Join me on Google+ and I'll show you around 🙂
About Ray Hiltz
Thanks for dropping by. I'm the Director of Digital Marketing for Image-24.com. My background in business includes non-profit (performing arts), restaurants and Promotions. Having moved on from my own strategic consulting company, I now write about what interests me. So in this blog, you may read about my thoughts on marketing, health issues and business culture. You can follow me on Twitter @rayhiltz or @image24Call


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Miu Miu Elasticated cut-out shoes
Lemon leather patent flat shoes with a cut-out detail at the toe. Miu Miu shoes have a button fastening strap across foot, an elasticated opening, contrast stitch detailing and a round toe.
Tags: shoes, green, wedges, flats, summer sandals, cut out shoes, matiko, St. Patrick's Day, Earth DayAdded 6 Years Ago from Urban Outfitters


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I knew a man by sight,
A blameless wight,
Who, for a year or more,
Had daily passed my door,
Yet converse none had had with him.
I met him in a lane,
Him and his cane,
About three miles from home,
Where I had chanced to roam,
And volumes stared at him, and he at me.
In a more distant place
I glimpsed his face,
And bowed instinctively;
Starting he bowed to me,
Bowed simultaneously, and passed along.
Next, in a foreign land
I grasped his hand,
And had a social chat,
About this thing and that,
As I had known him well a thousand years.
Late in a wilderness
I shared his mess,
For he had hardships seen,
And I a wanderer been;
He was my bosom friend, and I was his.
And as, methinks, shall all,
Both great and small,
That ever lived on earth,
Early or late their birth,
Stranger and foe, one day each other know.
Poet: Henry David Thoreau
Poem: I Knew A Man By Sight
Are you looking for more information on this poem? Perhaps you are trying to analyze it? The poem, I Knew A Man By Sight, has received 14 comments. Click here to read them, and perhaps post a comment of your own.
More Poems
(22 poems)
Henry David Thoreau books


text:
JAW-DROPPING Photos of Taylor Swift at Victoria's Secret Show
SERIOUSLY?! Whoever dressed Taylor for her performance at this year's Victoria's Secret Fashion Show deserves a major award. A medal. A million dollars. SOMETHING! Because Taylor Swift always looks great, but she has NEVER looked this fierce!
GONE are the 1950's style dresses and turtlenecks she's been wearing for the past year. Again, she looked lovely, but this new look...
This stunning, grown-up Taylor is literally flawless! I'm in awe. I'm jealous.
And I NEED that dress.
This... Is... Everything.
[photo credit for all images to Getty Images]
PHOTO GALLERY: 2013 Victoria's Secret Fashion Show


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[Date Index]
[Thread Index]
[Author Index]
Code generated by AutoGeneratedPackage->True
Prior to Mathematica 6, when the option AutoGeneratedPackage->True was
set, the resulting .m file contained text that was interpreted as
boxes and passed through MakeExpression before being evaluated. This
seems to have changed.
Can anyone confirm the details of this change? Is the change
documented somewhere?
This change breaks packages that use MakeExpression and rely on boxes
being created when executing the contents of the .m file. Is there a
way to recover the previous behaviour of AutoGeneratedPackage?


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Language - (hold down the CTRL key to select more than one):
lets add and call me at skype for speaking practice and even grammar.
skype name es-tele
- ESTELEO's blog
- Log in or register to post comments
Hola a todos!!
Hello everyone, my name is nathaniel gabriel moses, i am native english and i want to practice my spanish so if any one is interested my skype name is nathaniel.moses


text:
Muddy ditches near Calais serve as home to refugees from Darfur and Syria. Nick Harvey reports.
Articles by Nick Harvey
Out of sight, out of mind: refugees in purgatory
- November 13, 2014
- 0
There's now a cure for hepatitis C… but most can't afford it
Profit-focused drug companies are failing the ill, says Nick Harvey.
- April 14, 2014
- 19
Every newborn deserves the royal treatment
After the highly anticipated arrival of the heir to the throne, new parent Nick Harvey highlights the dangers of pregnancy and childbirth in Africa.
- July 23, 2013
- 1
Britain's shame: evicted islanders lose in court
The latest legal decision against the Chagossians, kicked off their homeland to make way for a US base, continues a regretful history, says Nick Harvey.
- June 12, 2013
- 1
Novartis 0 – World's Poor 1
While he celebrates India's Supreme Court ruling on a cancer drug patent, Nick Harvey warns the war for affordable medicines is not over.
- April 2, 2013
- 2
My brush with the 'health tourism' media mafia
Nick Harvey tried to debunk myths on migrants and the NHS on a London radio station, but was shouted down and left wondering why.
- March 5, 2013
- 4
Syria's civilians: when will the horror end?
Nick Harvey from Doctors of the World writes of the daily fear and violence faced by people caught up in the conflict.
- February 1, 2013
- 0
Pharma vs India: a case of life or death for the world's poor
Legal outcomes could 'open the floodgates' for companies to challenge generic drug production, keeping prices high, explains Nick Harvey.
- October 17, 2012
- 2
Why do some conflicts get more media coverage than others?
Nick Harvey considers the role – and the agenda – of the global media in making the news.
- September 1, 2012
- 0
Ex-Israeli soldier intent on Palestinian citizenship
A former Israeli military programmer, fed up with Israel's human rights violations in Palestine, is trying to renounce his Israeli nationality, reports Nick Harvey.
- June 13, 2012
- 6
Rio+20: The Great Greenwashers
The UN Earth summit will take place June 20-22. Here's introducing some of the worst environmental truth spinners trying to hijack the agenda.
- June 5, 2012
- 1
Feminists target Nike ahead of the Olympics
Nick Harvey reports on a campaign to expose sportswear firms who exploit women workers while boasting Olympic values.
- June 1, 2012
- 1
When Western therapies fail
Is a Western approach the best way to engage with the mental health issues of other cultures? Nick Harvey visits Burmese refugees in Thailand to find out.
- May 1, 2012
- 1
Frackers given the go ahead
Environmental activists are furious as a report published this week gives the green light for energy companies to drill for gas across the UK.
- April 17, 2012
- 0
Are ordinary Tuaregs becoming Mali conflict scapegoats?
Nick Harvey and Julien Tremblin look at the plight of Tuareg refugees caught in the crossfire of a conflict that's as devastating as it is complex.
- March 30, 2012
- 0
'We are all Alfie Meadows'
Uproar as 21-year-old student, who suffered severe head injuries at the 2010 anti-fees protests, is hauled into court on violent conduct charges.
- March 26, 2012
- 10
Brute forces: a year of rough injustice
On the International Day Against Police Brutality, Nick Harvey looks back on a busy year for out-of-control officers.
- March 1, 2012
- 3
Barclays wins 'shame' award
Barclays gets the recognition it deserves for making millions from speculating on food prices.
- January 30, 2012
- 0
Haiti: where did all the money go?
More than $10 billion was raised worldwide for Haiti after the earthquake. But, two years on, what have NGOs done with the cash? Nick Harvey investigates.
- January 1, 2012
- 1
West Papuans mark bitter-sweet 'independence' day
It's 50 years since West Papua first won independence, only for Indonesia to cruelly snatch it away. Nick Harvey reports on the tensions in the region.
- December 1, 2011
- 6
Johnson & Johnson shuns poor people with HIV
On World AIDS Day, a stark reminder of how Big Pharma drug patents deny HIV treatment to the developing world.
- December 1, 2011
- 0
West Papuan refugee threatened by Interpol arrest
Independence leader Benny Wenda has been named on an Interpol wanted list in a move viewed by many as politically motivated.
- November 25, 2011
- 3
Is the world's population really a timebomb?
The UN estimates there will be seven billion of us on this planet by the end of October. But talk of a 'population explosion' is alarmist, says Nick Harvey
- October 31, 2011
- 2
The shocking link between racism and schizophrenia
A migrant is up to five times more likely to be diagnosed with schizophrenia in the UK than a white British person. On World Mental Health Day, Nick Harvey argues that racial discrimination is to blame.
- October 10, 2011
- 18
Fracking hell
Nick Harvey reports on the movement against the destructive hydraulic fracturing or 'fracking' sites springing up across the UK.
- September 19, 2011
- 4
Demanding democracy in Swaziland
Fed up with near-zero democracy and rampant corruption, thousands have taken to the streets of Swaziland this week to call for change, reports Nick Harvey.
- September 7, 2011
- 1
West Papua: the road to freedom
Tuesday 2 August marked the 48th anniversary of the West Papuan struggle for independence from Indonesia. Now is the time for their voices to be heard, says Nick Harvey.
- August 4, 2011
- 11
Jungle orphans
Nick Harvey reports on the position of the Hmong – both inside Laos and the bleak refugee camps of Thailand.
- September 1, 2009
- 3
Tibet: 50 years from home
It is half a century since the Dalai Lama and thousands of other Tibetans were forced into exile by the Chinese occupation. Nick Harvey talks to exiles young and old about their hopes for their country.
- March 1, 2009
- 0
The Fire Inside
Women who love women still leads to suicide pacts in India, often burning themselves to death. But in the wake of a groundbreaking film, lesbians are asserting themselves more – and seeing some encouraging signs of change, as Nick Harvey reports.
- October 1, 2008
- 1
Queer India
Nick Harvey explains the background on gay rights – and then talks to lesbian activists about a cause that is beginning to catch fire.
- October 1, 2008
- 0


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Completely automatic tea bag packaging machine for heat-sealed double chamber filter bags with string, tag but without aluminium staple. IMA C2000 is one of the latest generation of machines produced by IMA in more than forty years, it represents the most advanced technical level in the sector, being capable of producing a variety of tea bag and carton styles. A tea bag without the presence of metallic material during infusion is the great advantage of this machine.


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WASHINGTON – Hurricane Sandy was kind to Joint Base Anacostia-Bolling (JBAB), located in Washington's southeast corner, as it was to most of the national capital region.
Joint Base Commander, Navy Capt. Anthony T. Calandra said, "Overall, JBAB rode the storm well. There was some minor damage to facilities, mostly missing roof tiles or detached gutters and two dozen downed trees and road signs."
"There were reports of leaky roofs, windows and doors in some housing areas, which were reported and addressed by the non-governmental housing partners responsible," said Calandra.
Good stewardship of base assets, including proper maintenance and repair of the facilities and landscape, combined with the ongoing mitigation of risks; having advanced warning of the storm and the preparation efforts undertaken by JBAB departments, mission partners and residents, likely contributed to minimize damage.
Ensuring that common base operations services, including utilities and other services are fully functional or restored quickly, is vital to the mission of JBAB and its mission partners. Those missions include providing national security, homeland security, lifesaving, homeland defense, presidential and ceremonial support.
Located on the banks of the Potomac and Anacostia Rivers, JBAB's biggest concern was the potential for moderate coastal flooding.
Throughout the storm, Sandy's winds pushed water up the Potomac and Anacostia Rivers and when combined with the twice daily astronomical tides, created what weather forecasters called, "Tidal anomalies of three to four feet."
A shift in the winds began allowing the water to begin flowing back downstream Wednesday, forecasters said. The flow is expected to continue for a few days.
While the base had small areas of minor flooding, Calandra said, "We had about 12 feet of sea wall remaining at high tide on Monday, during the height of the storm, so water coming over the wall seemed unlikely."
National Weather Service forecasters' predictions of wind gusts between 60-70 mph were realized when weather instruments at Regan National Airport, across the river from JBAB, recorded a 61 mph gust. Sustained winds of 50 mph were also documented.
Between 2 p.m. and 3 p.m., Tuesday, wind gusts in Montgomery County, Md. reached 68 mph. In Washington's upper atmosphere, near 1,000 feet above ground, winds of 80 mph were recorded.
Monday into Tuesday, rainfall rates reached two inches per hour, with a total accumulation of five to eight inches of rain throughout the area, the weather service reported.
JBAB personnel began preparing in earnest for Sandy, four days before its arrival. In some aspects, planning began well before.
JBAB Emergency Manager, Sigmund Evans, said, "Planning for all possible hazards, emergencies, disasters and incidents never stops. We use a continuous cycle that includes identifying and mitigating the hazards; planning our response to those we cannot fully mitigate; conducting various response and recovery exercises and drills; evaluating the results of those exercises and incorporating the lessons learned by revising our plans, thus starting the cycle again."
Severe weather events are one hazard that can be planned and exercised for, but not fully mitigated. Accordingly, JBAB's Public Works Department and other departments and mission partner agencies on base, as well as its residents, took proactive steps to ready themselves, the base facilities and their homes for the pending storm.
Sandbags were filled and placed, along with road barricades in flood prone areas, to reduce the likelihood that vehicles or people on foot would be caught in a flood.
Emergency, communications, vehicular, power tools and other equipment were fueled, tested and prepositioned in safe locations to ensure they would be ready for action when needed.
Security, Fire and Emergency Services resources were ready to respond to any threat or emergency. Emergency essential personnel, including DOD Police Officers, Air Force Security Forces, Firefighters, Paramedics, lodging, food service, public works and Incident Management Team personnel, reported ahead of the storm's arrival and remained at the base until released.
An on-base shelter location was identified, along with a backup location, should it be needed. Additionally, an additional shelter location, established by the district emergency management agency, was available near the base for JBAB residents and their district neighbors in Washington's Ward 8.
As "The Premier Joint Base" and like all military bases, a good neighbor, JBAB offered emergency assistance (Defense Support to Civil Authorities) to the district's government and its neighbors in Ward 8, represented by Councilman Marion Barry and Congresswoman Eleanor Holmes Norton, throughout the storm and after, if it were needed.
Calandra and Evans, along with Air Force Col. Michael Saunders, JBAB vice commander and other members of the JBAB Emergency Operations Center (EOC) staff, which comprised the base's Incident Management Team, monitored the storm's progress and when it arrived, its effects on JBAB, while continuing to coordinate response and recovery actions at the base.
A full night's sleep, relaxing bed and the comforts of home had to wait – The mission and preventing the loss of life came first.
JBAB's EOC maintained communications with the Naval District Washington (NDW) Regional Operations Center and other emergency command centers, including the district's Homeland Security Emergency Management Agency.
Beginning at first light on Tuesday, DOD police and JBAB firefighters from the Naval District Washington Fire and Emergency Services Central Battalion, joined members of the public works department and others to perform a comprehensive damage assessment and begin restoration efforts to ensure the base remained fully operational and able to perform its missions.
Wednesday morning, the base resumed normal operations and workers returned to the base – many for the first time since the weekend began. However, some were dressed as goblins, ghosts and pirates, in addition to the normal Sailors, Airmen, Soldiers, Coast Guardsmen and Marines.
Early Tuesday, while recovery efforts continued, but after the storm's greatest impact was gone, Calandra made the decision that plans for Wednesday's Halloween activities for the benefit of the many children living on base would continue as planned. "That includes our parade and trick or treating," he said.
The decision was popular among not only children, but parents as well. One parent wrote in an online post on Tuesday morning, "My daughters would be crushed if they didn't get to trick or treat tomorrow."
To help ensure the safety for children, especially when they are crossing streets, JBAB DOD Police Sgt. Ana Tarango, organized parents and other volunteers to augment police during trick or treat activities.
The adults, designated as "the Pumpkin Patrol," served as crossing guards, equipped with flashlights and reflective vests, after undergoing some basic training before being pressed into service, Tarango said. "This was especially important after the sun went down and the children in costumes might not have been as easy to see," she said.
Other adult volunteers and children assisted in checking the safety of candy and getting McGruff the Crime Dog around the base streets, as the large white dog with black spots, has challenges walking correctly on its hind legs for long periods of time, Tarango reported.
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This work, Hurricane Sandy kind to Joint Base; Nation's capital, by Joseph P Cirone, identified by DVIDS, is free of known copyright restrictions under U.S. copyright law.


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Development of an Updated Screening Model and Method for Routine and Non-Routine Flaring SpreadsheetAUPRF Air
Brian Zelt, Zelt PSI
Executive Summary
Improving air emissions estimation methodologies. Environment assessments are a key component to new and renewing facility approvals and licenses. A significant component of the assessment is for companies to demonstrate compliance with regulations and requirements relating to air emissions and ambient air quality. Companies use dispersion modeling as a method to predict facilities' compliance with the regulations. History shows that the dispersion modelling predictions are often much higher than measured concentrations. As such, industry would like to ground-truth or validate dispersion modeling software used for facility approvals.
CALPUFF is a software program universally accepted by the provincial regulators (AENV and ERCB) and industry for modelling the dispersion of SO2 from UOG facilities. Both industry and regulators would like to see the CALPUFF model to incorporate unique Alberta-specific algorithms around routine and non-routine flaring.
DISCLAIMER: PTAC does not warrant or make any representations or claims as to the validity, accuracy, currency, timeliness, completeness or otherwise of the information contained in this report , nor shall it be liable or responsible for any claim or damage, direct, indirect, special, consequential or otherwise arising out of the interpretation, use or reliance upon, authorized or unauthorized, of such information.
The material and information in this report are being made available only under the conditions set out herein. PTAC reserves rights to the intellectual property presented in this report, which includes, but is not limited to, our copyrights, trademarks and corporate logos. No material from this report may be copied, reproduced, republished, uploaded, posted, transmitted or distributed in any way, unless otherwise indicated on this report, except for your own personal or internal company use.


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Proven Gambling Secrets HTML version
Proven Gambling Secrets!
Losers! How to Avoid Becoming One
The chances of a person drawing a royal flush is the
same regardless of who he is. But why do some
people lose so much and why do other people seem
so damn lucky. You know the rules and you know the
odds, why is it your still losing. Loser? Probably not,
but to make sure check out this list. It won't
guarantee winning but might help you avoid the
loser tag.
1. Decide on how much you are willing to lose (and
People lose a lot of money gambling due to lack of
planning. They gamble way over their head because
they don't know when to stop. The reason being they
didn't plan when to stop.
2. Don't borrow other people's money to gamble
If you can't afford to lose money, don't play in the
first place. The added pressure of playing someone
else's money is too much. Losing your own money is
difficult enough, so if you don't have some, don't
3. Set the alarm.
If you've already decided how much you're willing to
lose, well and good. Now it's time to set a time limit.


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Guessing Apple's next move is sport for many people, and one of the current guesses for Apple was a large-size screen aimed at enterprise users. Now it's looking like that device will never see the light of day, which was a smart move.
People speculated on the existence of the "iPad Pro" due to clues coming from Apple's parts suppliers, who dropped hints of a 12.9-inch tablet that would compete with the Samsung Galaxy Note PRO 12.2. However, Taiwan-based DigiTimes reports the iPad Pro isn't coming. It has been shelved. Now granted, DigiTimes can be hit or miss, but in this case, it's probably a safe assumption that Apple won't release such a large tablet.
Why? Because no one wants them. IDC's tablet tracker makes this painfully obvious. The trend line is toward smaller, under 8-inch tablets. The larger ones, like the 9.7-inch models of the current iPad and Samsung Galaxy Note, are fading out. DigiTimes has its own market research arm and puts Galaxy Note Pro sales at just one million units for all of 2014. Apple sells that many iPads in a week.
These user patterns are not new. One of the first adopters of the Kindle were women, who found it easy to toss the small device in their purse and carry it with them. NPD told me this time and again. Lately, I'm seeing the pattern expand to men, who carry phablets and small tablets like the iPad Mini in coat pockets.
That's how I'm seeing iPad Mini and small Android tablets used in business today as well. The appeal is that they are easy to carry and not a notebook. Once you get into a 12.2-inch screen, you might as well use a laptop and then have access to all that Windows software.
That's why the Kindle DX, with its 9.7-inch screen and hefty 18.9 ounces, never went anywhere. It was too big and bulky. I've seen plenty of people out with regular Kindles, but never once saw a DX in public. For a while, it languished, until Amazon attempted to breathe new life into it, cutting the price from $379 to $239 last year.
The fact is the appeal of tablets and smartphones is that they are not laptops. Small, convenient, easy to carry and lightweight, they are meant to be truly portable devices. So it seems obvious to me Tim Cook and company read the tea leaves and saw that there is no market for this. If people want a 12-inch Apple device, they can just buy a MacBook Air and be done with it.


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Welcome to the website of the NAVMAT Dragons' Dragon Boat Racing Club.
Note: You are viewing this no-frills summary because your browser is not frame capable.
email: email@example.com
Our home waters are Lake Burley Griffin, Canberra, ACT.
Our normal training schedule includes a weekend session, plus two weeknights. This can vary depending on preparation for particular regattas (race meetings).
We have a strong beginners' programme, which includes a free trial offer. Our beginners' schedule includes a daytime paddle which (weather permitting) includes a stop for a coffee break (er, team meeting). While dragon boating is an active sport, it is like walking/running - anyone can do it, but you have to train to win races. At the sports level, dragon boat paddling is extremely energetic and the standards required to win even local races are quite high. However, it is great fun to learn, and quite addictive - the main requirement for improvement is practice and willingness to learn. You may not think such an energetic sport is suited to women, but we have a strong womens team.
We aim to race locally, nationally and internationally - in recent years, NAVMAT has sent teams to Penang every couple of years. Many of our members have joined Australian teams competing in China.
While we encourage members to develop their full sporting (ie, racing) potential, training 2-3 times per week for competition in local Regattas (and interstate Regattas), members are free to paddle on a social basis (ie, stay at beginner's level, with no hard training). Social paddling once per week enables you to help maintain a healthy fitness level and enjoy the particialrly attractive sights around the lake in the national capital.
Because dragon boating involves up to 22 people in a smallish boat, you have an instant social occasion every time you paddle. Of course, while training is in progress, it is important to stay focussed on the job in hand! But strong friendships develop while paddling together, and during warmup and warm-down activities - not to mention our social gatherings. We believe people give their best in a supportive, friendly atmosphere - which is easy in such a fun but energetic activity!
We cater for all adult age groups - whether you start young & fit, or not so young and/or not as fit as you would like, we can accomodate you. All you need is a desire to join in (a bit of a competitive spirit in a team atmosphere helps). In the past, a high proportion of NAVMATs (active) members have been included in ACT "state" teams. In national and internationall regattas, there are 4 age categories (and the ACT fields teams for the Australian Nationals in all 4): Premier (any age), Youth, Masters (over 40) and Grandmasters (over 50). In each age category, there are Womens events, Mixed events, and Open events.
So you see there is no excuse - if you want to have a go, we want you to! costs nothing to try. If you are already fit - we can help you develop your skills as fast as you can take it! If you are not fit, we'll help you get there. There's also an age category to suit you. If you want to start easy - well, you can stay in our beginner's programme as long as you like - stay with our Saturday morning "outings". If you want competition - there are opportunities to compete locally, and to try out for the ACT teams, and if you want to travel, there are opportunities to join teams going to China (for example). In recent times, NAVMAT has sent it's own team to Penang every couple of years.
Dragon Boat Racing is an ideal sport for corporate events - Christmas Parties, team "bonding". Also a good cross training exercise for other sports. Contact us for more details.


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We had a thread on him a ways back (search might find that) - but IIRC he is not all he seems! The vid would not load for me either.
Seems he takes things a bit far and will not tolerate anyone who opposes his methods. In essence tho he has become superficially at least, somewhat of a cult hero.


text:
- 85 total posts
- 1 review
- 4 discussions
- 79 comments
- 1 question
Reviews & Stories
Scared?? A Lot to Say! - Dallas, TX
Ok, I was approached to start a blog or my story, I think because I have taken up too much room in the forum. I have read many of your reviews so I will try and follow somewhat of a format. First, I am 37 years old and have had implants for five years. I will start with the fact that I have silicone gels under the muscle, I believe 325cc and 300cc because my breast were asymmetrical. I totally... READ MORE
Questions from wanttobeb
Will they be smaller than this? (photo)
Ok. I hope I can ask this clearly. This is a pic of me not long before pre-implant. When I went into the ps with these for a lift ( a lift ONLY). She said, no they will look... READ MORE
Discussions started by wanttobeb
Date Getting closer- doubts?????
Ok Ladies, This is getting serious. Any inputs/insights appreciated! Now that my sx date is 2 weeks away I'm starting to freak. Hear goes. I've had my implants for 5 years.... READ MORE
Rephrase of the question-doubts as dates get closer?
Well, I previously asked a question about dates getting closer and doubts, after realizing I wrote a book and many people probably didn't read it, as well as it seems it was... READ MORE
Preparations for recovery? What to expect?
I know there are probably plenty of posts/blogs concerning this but I can't seem to find them without reading for five hours. What are you doing to prepare for recovery? I saw... READ MORE
Any of you ladies feeling tired post-op??? day 6 post op
I am feeling tired, day 6 post-op. I'm wondering if I can blame it on my body healing...It seems I've read on some of your reviews how great you've felt post-op. I'm not really... READ MORE
Recent comments from wanttobeb
Thank you READ COMMENT
Thanks!! READ COMMENT
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Thank you. I am sure once I can start exercising I'll be wishing I had someone telling me I can't haha. READ COMMENT
Thank you. I am so glad. Now that the implants are out and I am feeling less emotional I am like, "hhhmmm did I put too much info, should I take my review down or edit the personal info?" but I guess if it helps... Your Dr. Sounds very... READ COMMENT


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Mutations in the isocitrate dehydrogenase genes
Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, Hideho Okada
Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that are important for organizing membrane domains and receptor signaling and regulating the migration of effector T cells. Whether moesin plays any role during the generation of TGF-β–induced Tregs (iTregs) is unknown. Here, we have discovered that moesin is translationally regulated by TGF-β and is also required for optimal TGF-β signaling that promotes efficient development of iTregs. Loss of moesin impaired the development and function of both peripherally derived iTregs and in vitro–induced Tregs. Mechanistically, we identified an interaction between moesin and TGF-β receptor II (TβRII) that allows moesin to control the surface abundance and stability of TβRI and TβRII. We also found that moesin is required for iTreg conversion in the tumor microenvironment, and the deletion of moesin from recipient mice supported the rapid expansion of adoptively transferred CD8+ T cells against melanoma. Our study establishes moesin as an important regulator of the surface abundance and stability of TβRII and identifies moesin's role in facilitating the efficient generation of iTregs. It also provides an advancement to our understanding about the role of the ERM proteins in regulating signal transduction pathways and suggests that modulation of moesin is a potential therapeutic target for Treg-related immune disorders.
Ephraim A. Ansa-Addo, Yongliang Zhang, Yi Yang, George S. Hussey, Breege V. Howley, Mohammad Salem, Brian Riesenberg, Shaoli Sun, Don C. Rockey, Serhan Karvar, Philip H. Howe, Bei Liu, Zihai Li
Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome the inherent T cell–independent nature of immune responses against glycans. Carbohydrate conjugate vaccines achieve this by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4 T cells to help B cell maturation. Yet they most often produce low- to medium-affinity immune responses of limited duration in immunologically fit individuals and disappointing results in the elderly and immunocompromised patients. Here, we hypothesized that these limitations result from suboptimal T cell help. To produce the next generation of more efficacious conjugate vaccines, we have explored a synthetic design aimed at focusing both B cell and T cell recognition to a single short glycan displayed at the surface of a virus-like particle. We tested and established the proof of concept of this approach for 2 serotypes of
Zinaida Polonskaya, Shenglou Deng, Anita Sarkar, Lisa Kain, Marta Comellas-Aragones, Craig S. McKay, Katarzyna Kaczanowska, Marie Holt, Ryan McBride, Valle Palomo, Kevin M. Self, Seth Taylor, Adriana Irimia, Sanjay R. Mehta, Jennifer M. Dan, Matthew Brigger, Shane Crotty, Stephen P. Schoenberger, James C. Paulson, Ian A. Wilson, Paul B. Savage, M.G. Finn, Luc Teyton
The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within
Maria A. Stacey, Simon Clare, Mathew Clement, Morgan Marsden, Juneid Abdul-Karim, Leanne Kane, Katherine Harcourt, Cordelia Brandt, Ceri A. Fielding, Sarah E. Smith, Rachael S. Wash, Silvia Gimeno Brias, Gabrielle Stack, George Notley, Emma L. Cambridge, Christopher Isherwood, Anneliese O. Speak, Zoë Johnson, Walter Ferlin, Simon A. Jones, Paul Kellam, Ian R. Humphreys
B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell–specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet–expressing B cells may be a potential target for therapy for autoimmune diseases.
Kira Rubtsova, Anatoly V. Rubtsov, Joshua M. Thurman, Johanna M. Mennona, John W. Kappler, Philippa Marrack
Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the tolerance status of MGCA has not been investigated. MGCA are considered to be uniformly immunogenic and nontolerogenic, and the prevailing view posits that MGCA are sequestered behind the Sertoli cell barrier in seminiferous tubules. Here, we have shown that only some murine MGCA are sequestered. Nonsequestered MCGA (NS-MGCA) egressed from normal tubules, as evidenced by their ability to interact with systemically injected antibodies and form localized immune complexes outside the Sertoli cell barrier. NS-MGCA derived from cell fragments that were discarded by spermatids during spermiation. They egressed as cargo in residual bodies and maintained Treg-dependent physiological tolerance. In contrast, sequestered MGCA (S-MGCA) were undetectable in residual bodies and were nontolerogenic. Unlike postvasectomy autoantibodies, which have been shown to mainly target S-MGCA, autoantibodies produced by normal mice with transient Treg depletion that developed autoimmune orchitis exclusively targeted NS-MGCA. We conclude that spermiation, a physiological checkpoint in spermatogenesis, determines the egress and tolerogenicity of MGCA. Our findings will affect target antigen selection in testis and sperm autoimmunity and the immune responses to CTA in male cancer patients.
Kenneth S.K. Tung, Jessica Harakal, Hui Qiao, Claudia Rival, Jonathan C.H. Li, Alberta G.A. Paul, Karen Wheeler, Patcharin Pramoonjago, Constance M. Grafer, Wei Sun, Robert D. Sampson, Elissa W.P. Wong, Prabhakara P. Reddi, Umesh S. Deshmukh, Daniel M. Hardy, Huanghui Tang, C. Yan Cheng, Erwin Goldberg
Defective apoptotic death of activated macrophages has been implicated in the pathogenesis of rheumatoid arthritis (RA). However, the molecular signatures defining apoptotic resistance of RA macrophages are not fully understood. Here, global transcriptome profiling of RA macrophages revealed that the osmoprotective transcription factor nuclear factor of activated T cells 5 (NFAT5) critically regulates diverse pathologic processes in synovial macrophages including the cell cycle, apoptosis, and proliferation. Transcriptomic analysis of NFAT5-deficient macrophages revealed the molecular networks defining cell survival and proliferation. Proinflammatory M1-polarizing stimuli and hypoxic conditions were responsible for enhanced NFAT5 expression in RA macrophages. An in vitro functional study demonstrated that NFAT5-deficient macrophages were more susceptible to apoptotic death. Specifically, CCL2 secretion in an NFAT5-dependent fashion bestowed apoptotic resistance to RA macrophages in vitro. Injection of recombinant CCL2 into one of the affected joints of
Susanna Choi, Sungyong You, Donghyun Kim, Soo Youn Choi, H. Moo Kwon, Hyun-Sook Kim, Daehee Hwang, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Kim
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores has not been rigorously investigated. In the present study, Western blotting identified a band corresponding to C3 in freshly isolated human peripheral blood cells that was absent in corresponding cell lines. One difference between native cells and cell lines was the time absent from a fluid-phase complement source; therefore, we hypothesized that loading C3 from plasma was a route of establishing intracellular C3 stores. We found that many types of human cells specifically internalized C3(H2O), the hydrolytic product of C3, and not native C3, from the extracellular milieu. Uptake was rapid, saturable, and sensitive to competition with unlabeled C3(H2O), indicating a specific mechanism of loading. Under steady-state conditions, approximately 80% of incorporated C3(H2O) was returned to the extracellular space. These studies identify an ICS recycling pathway for C3(H2O). The loaded C3(H2O) represents a source of C3a, and its uptake altered the cytokine profile of activated CD4+ T cells. Importantly, these results indicate that the impact of soluble plasma factors should be considered when performing in vitro studies assessing cellular immune function.
Michelle Elvington, M. Kathryn Liszewski, Paula Bertram, Hrishikesh S. Kulkarni, John P. Atkinson
Tissue inflammation is a key component of obesity-induced insulin resistance, with a variety of immune cell types accumulating in adipose tissue. Here, we have demonstrated increased numbers of B2 lymphocytes in obese adipose tissue and have shown that high-fat diet–induced (HFD-induced) insulin resistance is mitigated in B cell-deficient (Bnull) mice. Adoptive transfer of adipose tissue B2 cells (ATB2) from wild-type HFD donor mice into HFD Bnull recipients completely restored the effect of HFD to induce insulin resistance. Recruitment and activation of ATB2 cells was mediated by signaling through the chemokine leukotriene B4 (LTB4) and its receptor LTB4R1. Furthermore, the adverse effects of ATB2 cells on glucose homeostasis were partially dependent upon T cells and macrophages. These results demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitizing therapeutics.
Wei Ying, Joshua Wollam, Jachelle M. Ofrecio, Gautam Bandyopadhyay, Dalila El Ouarrat, Yun Sok Lee, Da Young Oh, Pingping Li, Olivia Osborn, Jerrold M. Olefsky
Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia. However, treatment of solid tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced immunosuppressive mechanisms, including adenosine production. Previous studies have shown that adenosine generated by tumor cells potently inhibits endogenous antitumor T cell responses through activation of adenosine 2A receptors (A2ARs). Herein, we have observed that CAR activation resulted in increased A2AR expression and suppression of both murine and human CAR T cells. This was reversible using either A2AR antagonists or genetic targeting of A2AR using shRNA. In 2 syngeneic HER2+ self-antigen tumor models, we found that either genetic or pharmacological targeting of the A2AR profoundly increased CAR T cell efficacy, particularly when combined with PD-1 blockade. Mechanistically, this was associated with increased cytokine production of CD8+ CAR T cells and increased activation of both CD8+ and CD4+ CAR T cells. Given the known clinical relevance of the CD73/adenosine pathway in several solid tumor types, and the initiation of phase I trials for A2AR antagonists in oncology, this approach has high translational potential to enhance CAR T cell efficacy in several cancer types.
Paul A. Beavis, Melissa A. Henderson, Lauren Giuffrida, Jane K. Mills, Kevin Sek, Ryan S. Cross, Alexander J. Davenport, Liza B. John, Sherly Mardiana, Clare Y. Slaney, Ricky W. Johnstone, Joseph A. Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H. Kershaw, Phillip K. Darcy
Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. An antagonistic anti-CCR4 antibody had antitumor activity in the RENCA mouse model of RCC. CCR4 inhibition did not reduce the proportion of infiltrating leukocytes in the tumor microenvironment but altered the phenotype of myeloid cells, increased NK cell and Th1 cytokine levels, and reduced immature myeloid cell infiltrate and blood chemokine levels. In spite of prominent changes in the myeloid compartment, the anti-CCR4 antibody did not affect RENCA tumors in T cell–deficient mice, and treatment with an anti–class II MHC antibody abrogated its antitumor activity. We concluded that the effects of the anti-CCR4 antibody required the adaptive immune system and CD4+ T cells. Moreover, CCL17-induced IFN-γ production was reduced when Th1-polarized normal CD4+ T cells were exposed to the CCR4 ligand, evidencing the involvement of CCR4 in Th1/Th2 regulation. The anti-CCR4 antibody, alone or in combination with other immune modulators, is a potential treatment approach to human solid cancers with high levels of CCR4-expressing tumor-infiltrating leukocytes and abnormal plasma CCR4 ligand levels.
Chiara Berlato, Moddasar N. Khan, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Anne Montfort, Maryam Jangani, Monica Canosa, Hagen Kulbe, Urs B. Hagemann, Alexander R. Duncan, Laura Fletcher, Robert W. Wilkinson, Thomas Powles, Sergio A. Quezada, Frances R. Balkwill
MicroRNAs (miRs) are tightly regulated in the immune system, and aberrant expression of miRs often results in hematopoietic malignancies and autoimmune diseases. Previously, it was suggested that elevated levels of miR-27 in T cells isolated from patients with multiple sclerosis facilitate disease progression by inhibiting Th2 immunity and promoting pathogenic Th1 responses. Here we have demonstrated that, although mice with T cell–specific overexpression of miR-27 harbor dysregulated Th1 responses and develop autoimmune pathology, these disease phenotypes are not driven by miR-27 in effector T cells in a cell-autonomous manner. Rather, dysregulation of Th1 responses and autoimmunity resulted from a perturbed Treg compartment. Excessive miR-27 expression in murine T cells severely impaired Treg differentiation. Moreover, Tregs with exaggerated miR-27–mediated gene regulation exhibited diminished homeostasis and suppressor function in vivo. Mechanistically, we determined that miR-27 represses several known as well as previously uncharacterized targets that play critical roles in controlling multiple aspects of Treg biology. Collectively, our data show that miR-27 functions as a key regulator in Treg development and function and suggest that proper regulation of miR-27 is pivotal to safeguarding Treg-mediated immunological tolerance.
Leilani O. Cruz, Somaye Sadat Hashemifar, Cheng-Jang Wu, Sunglim Cho, Duc T. Nguyen, Ling-Li Lin, Aly Azeem Khan, Li-Fan Lu
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV infection, yet the mechanisms driving these processes are unclear. Chronic activation can be a driving force in immune exhaustion, and type I interferons (IFN-I) are emerging as critical components underlying ongoing activation in HIV infection. Here, we have tested the effect of blocking IFN-I signaling on T cell responses and virus replication in a murine model of chronic HIV infection. Using HIV-infected humanized mice, we demonstrated that in vivo blockade of IFN-I signaling during chronic HIV infection diminished HIV-driven immune activation, decreased T cell exhaustion marker expression, restored HIV-specific CD8 T cell function, and led to decreased viral replication. Antiretroviral therapy (ART) in combination with IFN-I blockade accelerated viral suppression, further decreased viral loads, and reduced the persistently infected HIV reservoir compared with ART treatment alone. Our data suggest that blocking IFN-I signaling in conjunction with ART treatment can restore immune function and may reduce viral reservoirs during chronic HIV infection, providing validation for IFN-I blockade as a potential therapy for HIV infection.
Anjie Zhen, Valerie Rezek, Cindy Youn, Brianna Lam, Nelson Chang, Jonathan Rick, Mayra Carrillo, Heather Martin, Saro Kasparian, Philip Syed, Nicholas Rice, David G. Brooks, Scott G. Kitchen
Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described biallelic mutations in
Emily M. Mace, Venetia Bigley, Justin T. Gunesch, Ivan K. Chinn, Laura S. Angelo, Matthew A. Care, Sheetal Maisuria, Michael D. Keller, Sumihito Togi, Levi B. Watkin, David F. LaRosa, Shalini N. Jhangiani, Donna M. Muzny, Asbjørg Stray-Pedersen, Zeynep Coban Akdemir, Jansen B. Smith, Mayra Hernández-Sanabria, Duy T. Le, Graham D. Hogg, Tram N. Cao, Aharon G. Freud, Eva P. Szymanski, Sinisa Savic, Matthew Collin, Andrew J. Cant, Richard A. Gibbs, Steven M. Holland, Michael A. Caligiuri, Keiko Ozato, Silke Paust, Gina M. Doody, James R. Lupski, Jordan S. Orange
MHC class I–associated peptides (MAPs) define the immune self for CD8+ T lymphocytes and are key targets of cancer immunosurveillance. Here, the goals of our work were to determine whether the entire set of protein-coding genes could generate MAPs and whether specific features influence the ability of discrete genes to generate MAPs. Using proteogenomics, we have identified 25,270 MAPs isolated from the B lymphocytes of 18 individuals who collectively expressed 27 high-frequency HLA-A,B allotypes. The entire MAP repertoire presented by these 27 allotypes covered only 10% of the exomic sequences expressed in B lymphocytes. Indeed, 41% of expressed protein-coding genes generated no MAPs, while 59% of genes generated up to 64 MAPs, often derived from adjacent regions and presented by different allotypes. We next identified several features of transcripts and proteins associated with efficient MAP production. From these data, we built a logistic regression model that predicts with good accuracy whether a gene generates MAPs. Our results show preferential selection of MAPs from a limited repertoire of proteins with distinctive features. The notion that the MHC class I immunopeptidome presents only a small fraction of the protein-coding genome for monitoring by the immune system has profound implications in autoimmunity and cancer immunology.
Hillary Pearson, Tariq Daouda, Diana Paola Granados, Chantal Durette, Eric Bonneil, Mathieu Courcelles, Anja Rodenbrock, Jean-Philippe Laverdure, Caroline Côté, Sylvie Mader, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. RABGEF1-deficient keratinocytes exhibited aberrant activation of the intrinsic IL-1R/MYD88/NF-κB signaling pathway and MYD88-dependent abnormalities in expression of structural proteins that contribute to skin barrier function. Moreover, ablation of MYD88 signaling in RABGEF1-deficient keratinocytes or deletion of
Thomas Marichal, Nicolas Gaudenzio, Sophie El Abbas, Riccardo Sibilano, Oliwia Zurek, Philipp Starkl, Laurent L. Reber, Dimitri Pirottin, Jinah Kim, Pierre Chambon, Axel Roers, Nadine Antoine, Yuko Kawakami, Toshiaki Kawakami, Fabrice Bureau, See-Ying Tam, Mindy Tsai, Stephen J. Galli
The transcription factor NR4A3 (also known as NOR-1) is a member of the
Kiwon Park, Zbigniew Mikulski, Goo-Young Seo, Aleksander Y. Andreyev, Paola Marcovecchio, Amy Blatchley, Mitchell Kronenberg, Catherine C. Hedrick
Chronic inflammation in visceral adipose tissue (VAT) precipitates the development of cardiometabolic disorders. Although changes in T cell function associated with visceral obesity are thought to affect chronic VAT inflammation, the specific features of these changes remain elusive. Here, we have determined that a high-fat diet (HFD) caused a preferential increase and accumulation of CD44hiCD62LloCD4+ T cells that constitutively express PD-1 and CD153 in a B cell–dependent manner in VAT. These cells possessed characteristics of cellular senescence and showed a strong activation of
Kohsuke Shirakawa, Xiaoxiang Yan, Ken Shinmura, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Tsunehisa Yamamoto, Atsushi Anzai, Sarasa Isobe, Naohiro Yoshida, Hiroshi Itoh, Ichiro Manabe, Miho Sekai, Yoko Hamazaki, Keiichi Fukuda, Nagahiro Minato, Motoaki Sano
Natural killer (NK) cells can have potent antileukemic activity following haplo-mismatched, T cell–depleted stem cell transplantations for the treatment of acute myeloid leukemia (AML), but they are not successful in eradicating de novo AML. Here, we have used a mouse model of de novo AML to elucidate the mechanisms by which AML evades NK cell surveillance. NK cells in leukemic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B. Further, as AML progressed, we noted the selective loss of an immature subset of NK cells in leukemic mice and in AML patients. This absence was not due to elimination by cell death or selective reduction in proliferation, but rather to the result of a block in NK cell differentiation. Indeed, NK cells from leukemic mice and humans with AML showed lower levels of TBET and EOMES, transcription factors that are critical for terminal NK cell differentiation. Further, the microRNA miR-29b, a regulator of T-bet and EOMES, was elevated in leukemic NK cells. Finally, deletion of miR-29b in NK cells reversed the depletion of this NK cell subset in leukemic mice. These results indicate that leukemic evasion of NK cell surveillance occurs through miR-mediated dysregulation of lymphocyte development, representing an additional mechanism of immune escape in cancer.
Bethany L. Mundy-Bosse, Steven D. Scoville, Li Chen, Kathleen McConnell, Hsiaoyin C. Mao, Elshafa H. Ahmed, Nicholas Zorko, Sophia Harvey, Jordan Cole, Xiaoli Zhang, Stefan Costinean, Carlo M. Croce, Karilyn Larkin, John C. Byrd, Sumithira Vasu, William Blum, Jianhua Yu, Aharon G. Freud, Michael A. Caligiuri
The rising success of cancer immunotherapy has produced immense interest in defining the clinical contexts that may benefit from this therapeutic approach. To this end, there is a need to ascertain how the therapeutic modulation of intrinsic cancer cell programs influences the anticancer immune response. For example, the role of autophagy as a tumor cell survival and metabolic fitness pathway is being therapeutically targeted in ongoing clinical trials that combine cancer therapies with antimalarial drugs for the treatment of a broad spectrum of cancers, many of which will likely benefit from immunotherapy. However, our current understanding of the interplay between autophagy and the immune response remains incomplete. Here, we have evaluated how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer. We observed equivalent levels of T cell infiltration and function within autophagy-competent and -deficient tumors, even upon treatment with the anthracycline chemotherapeutic doxorubicin. Similarly, we found equivalent T cell responses upon systemic treatment of tumor-bearing mice with antimalarial drugs. Our findings demonstrate that antitumor adaptive immunity is not adversely impaired by autophagy inhibition in these models, allowing for the future possibility of combining autophagy inhibitors with immunotherapy in certain clinical contexts.
Hanna Starobinets, Jordan Ye, Miranda Broz, Kevin Barry, Juliet Goldsmith, Timothy Marsh, Fanya Rostker, Matthew Krummel, Jayanta Debnath


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Moozi brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 17 Designs von 11 Designern wurde eine Gewinner gewählt.
We are after a logo designed for our college that will be recognized at international level. The logo must be highly professional and will be critiqued by our creative people, so put in your best efforts. :)
Horwood International College
The logo will be used on stationery, websites, publications, uniforms and others, so it needs to be easily transferable.
The company is an International College for teaching non-english speaking people to speak english and will deal with governments and other large organizations.
- Looks good.
- Looks professional
- Eye-catching at any size. Small or large.
- Striking but not cluttered or too much going on.
- Item 1...


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Royal National Mod Cup winners 2015/16
Jimmy Marshall Cup winners 2013/14
Oban Saints Football Club Main Sponsors Season 2015 - 2016
DIRECTIONS TO MOSSFIELD STADIUM AND GLENCRUITTEN PARK - PA34 4EJ Come down the hill into the town - follow main street till you come to a roundabout. National flags round it. (Aulay's Bar and the Royal Hotel on your left). Keep left at roundabout - follow signs for Campbeltown. Go through a set of pedestrian lights and follow road (400 yards) till you come to a church. Go left just in front of the church, then 3rd right (before red blaes football pitch) into Mossfield Avenue. Follow this road (200 yards) - go left at big blue gates (Mossfield Stadium) then 1st left into Glencruitten Drive. Follow this road (200 yards) go over a small bridge and you'll come to Oban Lorne Rugby Club where we change. Both parks are only a short walk from the rugby club


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Thanks PureH@te and Parrot
for some reason every time i try using the this list it keeps saying it is an empty list. Anyone else having this problem?
Thanks PureH@te and Parrot
if the original hatelist file is corrupt, is a clean version available? if not, any advise on how to clean it up?
"You shot who in the what now?"
This is dedicated to all those who think that the hatelist is corrupt. I assure you that it is not, it works perfect for me. All you have to do is to work your mind a little bit.
In order to open the hatelist you need a text editor.
Usually, a text editor cannot handle files larger than 512 MB.
So what we do is split the file into pieces.
There are some decent file splitters and mergers for windows but I suggest you do this in a Linux or Unix terminal.
So to split the file use the split command:
split --bytes=50m hatelist.txt hatelist_
This command will split hatelist.txt into files of 50 MB in size and name the various parts hatelist_aa, hatelist_ab and so on. You can change b for bytes, k for Kilobytes and m for Megabytes to specify the size.
Basically, that's it! Now you can use your favourite application to crack a password using the various hatelist files.
e.g. "aircrack-ng psk-*.cap -w hatelist_aa"
With aircrack it usually takes an hour to test the contents of the list.
If anyone wants to edit the list and remove the html tags, you can split the list into files of your prefered size and edit them on your own. Then you can merge the corrected lists of files into one big file with the cat command.
cat hatelist_* > mergedFile.txt
Hope this helps!
Lincoln's link works fine here.
The new link works fine. Thanks mate
how many exactly words are in this hatelist ? over 64 mill ?


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Eco funerals
More people are opting for a natural burial or eco funeral, ensuring they can leave one final statement behind on how they cared for the environment.
Hamilton is looking to establish its first natural burial site – having a natural burial site within the Hamilton Park Cemetery. There are more than 300 natural burial sites in the United Kingdom and more than a dozen in the United States but the idea has taken longer to catch on in New Zealand because people aren't allowed to be buried on private land. But that doesn't mean there is a lack of interest.
People are wanting an alternative to the traditional burial, which involves a standard casket, embalming and often burials six feet deep.
A natural burial is free of chemicals and a person is buried only 50 centimetres to one metre deep, the best depth for a body to decompose. The body is not embalmed, but is kept refrigerated instead, or treated with oils. A natural casket, cardboard or shroud is used instead of a standard casket which is usually made from treated wood.
A tree, instead of a plaque, is planted on top of where the body is buried.
About 5 per cent to 10 per cent of people are now choosing not to be embalmed . It all comes down to choice. At Rosetown Funerals we can discuss all of the options.