text:
A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors
This study has been completed.
Hoffmann-La Roche
Information provided by (Responsible Party):
Hoffmann-La Roche
ClinicalTrials.gov Identifier:
First received: April 7, 2011
Last updated: November 1, 2016
Last verified: November 2016
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This randomized, open-label, parallel-group, multicenter study will evaluate the rate of cardiovascular events with tocilizumab in comparison to etanercept in participants with rheumatoid arthritis (RA). Participants will be randomized to receive intravenous (IV) 8 milligrams per kilogram (mg/kg) tocilizumab every 4 weeks or subcutaneous 50 milligrams (mg) etanercept weekly, with or without non-biologic disease-modifying anti-rheumatic drug (DMARD).
|Rheumatoid Arthritis
|Drug: Etanercept Drug: Tocilizumab
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Clinical Outcomes Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) in Comparison With Etanercept (ETA) on the Rate of Cardiovascular Events in Patients With Moderate to Severe Rheumatoid Arthritis (RA)
Resource links provided by NLM:
Genetics Home Reference related topics: rheumatoid arthritis
MedlinePlus related topics: Arthritis Rheumatoid Arthritis
Drug Information available for: Etanercept TocilizumabU.S. FDA Resources
Further study details as provided by Hoffmann-La Roche:
Primary Outcome Measures:
- Time to First Occurrence of Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event, Defined as a Composite of CV Death, Non-Fatal Myocardial Infarction, and Non-Fatal Stroke [ Time Frame: Baseline up to 4.9 years ]
Secondary Outcome Measures:
- Time to First Occurrence of Expanded Composite Endpoint, Defined as a Composite of CV Death, Non-Fatal Myocardial Infarction, Non-Fatal Stroke, Non-Elective Coronary Revascularization Procedures, and Hospitalization for Unstable Angina [ Time Frame: Baseline up to 4.9 years ]
- Percentage of Participants with Adverse Events (AEs) and Serious AEs (SAEs) [ Time Frame: Baseline up to 4.9 years ]
|Study Start Date:
|August 2011
|Study Completion Date:
|March 2016
|Primary Completion Date:
|March 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Active Comparator: Etanercept
Drug: Etanercept
Participants will receive 50 mg etanercept subcutaneously weekly until switch to another RA therapy or up to 4.9 years.
|Experimental: Tocilizumab
Drug: Tocilizumab
Participants will receive 8 mg/kg tocilizumab IV every 4 weeks until switch to another RA therapy or up to 4.9 years.
Other Name: Actemra
|Ages Eligible for Study:
|50 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Participants with moderate to severe RA of greater than or equal to (>=6) months duration
- Inadequate response to at least one non-biologic DMARD
- Positive for Rheumatoid Factor (RF) and/or anti-cyclic citrullinated peptide (CCP) antibodies at screening
- Have C-reactive protein (CRP) greater than (>) 0.3 milligrams per deciliter (mg/dL) at screening or at the baseline visit
- Swollen joint count (SJC) >=8 (66 joint count) and tender joint count (TJC) >= 8 (68 joint count) during screening or at the baseline visit
- History of Coronary Heart Disease (CHD) or presence of one or more additional CHD risk factors, including current cigarette smoking, hypertension, low High Density Lipoprotein (HDL) cholesterol, family history of premature CHD, diabetes, presence of extra-articular disease associated with rheumatoid arthritis
- At the time of randomization, will have discontinued infliximab, adalimumab, golimumab, or certolizumab for >= 4 weeks
Exclusion Criteria:
- Major surgery (including joint surgery or coronary revascularization) within 8 weeks prior to screening or planned major surgery within 1 year of study start
- Rheumatic autoimmune disease other than RA
- History of or current inflammatory joint disease other than RA
- Current or recent (within past 3 months) evidence of serious uncontrolled concomitant cardiovascular or cerebrovascular disease (myocardial infarction, revascularization, stroke, transient ischemic attack, or acute coronary syndrome)
- Current or previous (within the past 2 years) evidence of serious uncontrolled concomitant pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (including uncontrolled diabetes mellitus) or gastrointestinal disease
- Uncontrolled disease states, such as asthma or inflammatory bowel disease where flares are commonly treated with oral or parenteral corticosteroids
- Pre-existing central nervous system demyelinating or seizure disorders
- History of diverticulitis, diverticulosis requiring treatment or other lower gastrointestinal tract conditions that might predispose to perforations
- Current liver disease as determined by the investigator; a history of asymptomatic elevations in liver function tests (LFTs) is not considered an exclusion
- Active current infection or history of recurrent bacterial, viral, fungal, mycobacterial or other infections, including but not limited to tuberculosis and atypical mycobacterial disease, hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds
- Any major episode of infection requiring hospitalization or treatment with IV antibiotics within four weeks of screening or oral antibiotics within two weeks prior to screening visit
- Active tuberculosis (TB) requiring treatment within 3 years prior to baseline
- Latent TB diagnosed during screening that has not been appropriately treated
- Primary or secondary immunodeficiency (history of or currently active)
- Moderate to severe heart failure
- Evidence of active malignant disease, malignancies diagnosed within the previous 10 years (including hematologic malignancies and solid tumors, except basal cell carcinoma of the skin that has been excised and cured), or breast cancer diagnosed within the previous 20 years
- Breast feeding mothers
- History of alcohol, drug or chemical abuse within the 6 months prior to screening
- Participants with lack of peripheral venous access
- Participants with a history of allergic reactions to latex
- Previous treatment with non-tumor necrosis factor (non-TNF)-inhibitor biologic therapy
- Treatment with any investigational agent within 4 weeks of screening visit
- Treatment with any cell depleting therapies within 1 year of baseline
- Treatment with IV gamma globulin, plasmapheresis or Prosorba column within 6 months of baseline visit
- Immunization with a live/attenuated vaccine within 4 weeks prior to baseline visit
- Any previous treatment with alkylating agents, such as cyclophosphamide or chlorambucil, or with total lymphoid irradiation
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01331837
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01331837
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|United States, Alabama
|Birmingham, Alabama, United States, 35294
|Huntsville, Alabama, United States, 35801
|Tuscaloosa, Alabama, United States, 35406
|United States, Arizona
|Glendale, Arizona, United States, 85306
|Paradise Valley, Arizona, United States, 85253
|Peoria, Arizona, United States, 85381
|Phoenix, Arizona, United States, 85027
|Scottsdale, Arizona, United States, 85258
|Tucson, Arizona, United States, 85724
|Tuscon, Arizona, United States, 85715
|United States, Arkansas
|Jonesboro, Arkansas, United States, 72401
|Little Rock, Arkansas, United States, 72205
|United States, California
|Covina, California, United States, 91723
|Huntington Beach, California, United States, 92646
|La Jolla, California, United States, 92037
|Los Alamitos, California, United States, 90720
|Mission Viejo, California, United States, 92692
|Murrieta, California, United States, 92563
|Poway, California, United States, 92064
|San Diego, California, United States, 92108
|San Diego, California, United States, 92120
|San Leandro, California, United States, 94578
|Santa Maria, California, United States, 93454
|Santa Monica, California, United States, 90404
|Torrance, California, United States, 90509
|Upland, California, United States, 91786
|Whittier, California, United States, 90606
|United States, Colorado
|Colorado Springs, Colorado, United States, 80920
|United States, Connecticut
|Bridgeport, Connecticut, United States, 06606
|Farmington, Connecticut, United States, 06030
|Hamden, Connecticut, United States, 06518
|United States, Florida
|Boynton Beach, Florida, United States, 33472
|Coral Gables, Florida, United States, 33134
|Daytona Beach, Florida, United States, 32117
|Jacksonville, Florida, United States, 32216
|Miami, Florida, United States, 33126
|Orange Park, Florida, United States, 32073
|Palm Habor, Florida, United States, 34684
|Pensacola, Florida, United States, 32501
|Sarasota, Florida, United States, 34292
|South Miami, Florida, United States, 33143
|St. Petersburg, Florida, United States, 33708
|Tampa, Florida, United States, 33609
|Tampa, Florida, United States, 33614
|United States, Georgia
|Atlanta, Georgia, United States, 30303
|Atlanta, Georgia, United States, 30342
|Duluth, Georgia, United States, 30096
|Rome, Georgia, United States, 30165
|Savannah, Georgia, United States, 31405
|United States, Idaho
|Boise, Idaho, United States, 83702
|Boise, Idaho, United States, 83704
|Coeur D'alene, Idaho, United States, 83814
|Meridian, Idaho, United States, 83642
|United States, Illinois
|Chicago, Illinois, United States, 60612
|Chicago, Illinois, United States, 60616
|Peoria, Illinois, United States, 61602
|United States, Indiana
|Fort Wayne, Indiana, United States, 46804
|Indianapolis, Indiana, United States, 46227
|South Bend, Indiana, United States, 46601
|United States, Kentucky
|Bowling Green, Kentucky, United States, 42101
|Owensboro, Kentucky, United States, 42303
|United States, Louisiana
|Monroe, Louisiana, United States, 71203
|New Orleans, Louisiana, United States, 70121
|United States, Maryland
|Baltimore, Maryland, United States, 21286
|Hagerstown, Maryland, United States, 21740
|Wheaton, Maryland, United States, 20902
|United States, Massachusetts
|Fall River, Massachusetts, United States, 02720
|Worcester, Massachusetts, United States, 01605
|Worcester, Massachusetts, United States, 01610
|United States, Michigan
|Flint, Michigan, United States, 48503
|Kalamazoo, Michigan, United States, 49009
|Lansing, Michigan, United States, 48910
|Petoskey, Michigan, United States, 49770
|United States, Minnesota
|Eagan, Minnesota, United States, 55121
|Minneapolis, Minnesota, United States, 55417
|Rochester, Minnesota, United States, 55905
|United States, Mississippi
|Flowood, Mississippi, United States, 39232
|Tupelo, Mississippi, United States, 38801
|United States, Montana
|Kalispell,, Montana, United States, 59901
|United States, Nebraska
|Omaha, Nebraska, United States, 68198
|United States, Nevada
|Las Vegas, Nevada, United States, 89123
|Las Vegas, Nevada, United States, 89128
|United States, New Hampshire
|Lebanon, New Hampshire, United States, 03756
|Nashua, New Hampshire, United States, 03060
|United States, New Jersey
|Berkeley Heights, New Jersey, United States, 07922
|Teaneck, New Jersey, United States, 07666
|Voorhees, New Jersey, United States, 08043
|United States, New Mexico
|Albuquerque, New Mexico, United States, 87102
|Las Cruces, New Mexico, United States, 88011
|United States, New York
|Brooklyn, New York, United States, 11201
|Brooklyn, New York, United States, 11203
|North Massapequa, New York, United States, 11758
|Olean, New York, United States, 14760
|Syracuse, New York, United States, 13210
|United States, North Carolina
|Asheville, North Carolina, United States, 28803
|Charlotte, North Carolina, United States, 28204
|Charlotte, North Carolina, United States, 28210
|Durham, North Carolina, United States, 27704
|Hickory, North Carolina, United States, 28602
|Raleigh, North Carolina, United States, 27617
|Sanford, North Carolina, United States, 27330
|Wilmington, North Carolina, United States, 28401
|United States, North Dakota
|Minot, North Dakota, United States, 58701
|United States, Ohio
|Cincinnati, Ohio, United States, 45219
|Cleveland, Ohio, United States, 44109
|Columbus, Ohio, United States, 43210
|Columbus, Ohio, United States, 43215
|Toledo, Ohio, United States, 43606
|Toledo, Ohio, United States, 43623
|United States, Oklahoma
|Oklahoma City, Oklahoma, United States, 73112
|United States, Pennsylvania
|Duncansville, Pennsylvania, United States, 16635
|Hershey, Pennsylvania, United States, 17033
|Indiana, Pennsylvania, United States, 15701
|Limerick, Pennsylvania, United States, 19468
|Perkasie, Pennsylvania, United States, 18944
|Philadelphia, Pennsylvania, United States, 19152
|Pittsburgh, Pennsylvania, United States, 15213-2582
|Wexford, Pennsylvania, United States, 15090
|Wyomissing, Pennsylvania, United States, 19610
|United States, South Carolina
|Columbia, South Carolina, United States, 29204
|Myrtle Beach, South Carolina, United States, 29572
|United States, South Dakota
|Watertown, South Dakota, United States, 57201
|United States, Tennessee
|Memphis, Tennessee, United States, 38119
|United States, Texas
|Amarillo, Texas, United States, 79124
|Corpus Christi, Texas, United States, 78404
|Dallas, Texas, United States, 75231
|Fort Worth, Texas, United States, 76109
|Houston, Texas, United States, 77004
|Houston, Texas, United States, 77074
|Mesquite, Texas, United States, 75150
|Richardson, Texas, United States, 75080
|San Antonio, Texas, United States, 78217
|Waco, Texas, United States, 76710
|United States, Virginia
|Burke, Virginia, United States, 22015
|Norfolk, Virginia, United States, 23510
|United States, Washington
|Kennewick, Washington, United States, 99336
|Seattle, Washington, United States, 98104
|Tacoma, Washington, United States, 98405
|United States, West Virginia
|Beckley, West Virginia, United States, 25801
|Clarksburg, West Virginia, United States, 26301
|United States, Wisconsin
|Racine, Wisconsin, United States, 53406
|Buenos Aires, Argentina, C1015ABO
|Buenos Aires, Argentina, C1117ABK
|Buenos Aires, Argentina, C1194AAO
|Buenos Aires, Argentina, C1204AAD
|Buenos Aires, Argentina, C1425DTG
|Buenos Aires, Argentina, C1426AAL
|Buenos Aires, Argentina, C1431FWO
|Ciudad Autonoma Buenos Aires, Argentina, C1221ADC
|Ciudad Autonoma Buenos Aires, Argentina, C1284AEB
|Ciudad Autonoma de Buenos Aires, Argentina, 1111
|Cordoba Pcia, Argentina, 5016
|Cordoba, Argentina, 5000
|Cordoba, Argentina, X5004BAL
|Florencio Varela, Argentina, 1888
|Lujan, Argentina, 6700
|Pergamino, Argentina, B2700CPM
|Rosario, Santa Fe, Argentina, S2000PBJ
|Rosario, Argentina, S2000DSV
|San Juan, Argentina, 5400
|San Miguel de Tucuman, Argentina, T4000AXL
|Tucuman, Argentina, 4000
|Graz, Austria, 8036
|Stockerau, Austria, 2000
|Wien, Austria, 1090
|Wien, Austria, 1100
|Wien, Austria, 1130
|Brussels, Belgium, 1000
|Bruxelles, Belgium, 1200
|Kortrijk, Belgium, 8500
|Liège, Belgium, 4000
|Merksem, Belgium, 2170
|Bosnia and Herzegovina
|Banja Luka, Bosnia and Herzegovina, 78000
|Sarajevo, Bosnia and Herzegovina, 71 000
|Sarajevo, Bosnia and Herzegovina, 71000
|Tuzla, Bosnia and Herzegovina, 75000
|Canada, Alberta
|Edmonton, Alberta, Canada, T5H 3V9
|Canada, British Columbia
|Powell River, British Columbia, Canada, V8A 3B6
|Victoria, British Columbia, Canada, V8P 5P6
|Canada, Newfoundland and Labrador
|St John's, Newfoundland and Labrador, Canada, A1A 5E8
|St John's, Newfoundland and Labrador, Canada, A1C 5B8
|Canada, Ontario
|Etobicoke, Ontario, Canada, M9C 5N2
|Hamilton, Ontario, Canada, L8N 1Y2
|Kitchener, Ontario, Canada, N2M 5N6
|London, Ontario, Canada, N6A 4V2
|Mississauga, Ontario, Canada, L5M 2V8
|St. Catharines, Ontario, Canada, L2N 7E4
|Toronto, Ontario, Canada, M5G 1Z5
|Canada, Quebec
|Montreal, Quebec, Canada, H2L 1S6
|Quebec City, Quebec, Canada, G1V 3M7
|Sherbrooke, Quebec, Canada, J1H 5N4
|Trois-rivieres, Quebec, Canada, G8Z 1Y2
|Quebec, Canada, G1W 4R4
|La Serena, Chile, 1700000
|Santiago, Chile, 7500000
|Santiago, Chile, 7500035
|Santiago, Chile, 7501126
|Santiago, Chile, 8320112
|Temuco, Chile, 4780000
|Viña del Mar, Chile, 2520612
|Viña del Mar, Chile, 2570017
|Karlovac, Croatia, 47000
|Krapinske Toplice, Croatia, 49217
|Rijeka, Croatia, 51000
|Zagreb, Croatia, 10000
|Czech Republic
|Brno, Czech Republic, 656 91
|Bruntal, Czech Republic, 792 01
|Hlucin, Czech Republic, 748 01
|Hostivice, Czech Republic, 253 01
|Kladno, Czech Republic, 272 01
|Ostrava - Moravska Ostrava, Czech Republic, 702 00
|Praha 4, Czech Republic, 140 00
|Praha, Czech Republic, 128 50
|Praha, Czech Republic, 140 59
|Sokolov, Czech Republic, 356 01
|Terezin, Czech Republic, 411 55
|Zlin, Czech Republic, 748 01
|Cuenca, Ecuador, 101168
|Guayaquil, Ecuador, 593
|Guayaquil, Ecuador, EC090114
|Quito, Ecuador, 005932
|Quito, Ecuador, EC170517
|Amiens, France, 80054
|Bordeaux, France, 33000
|Clermont Ferrand, France, 63003
|Corbeil Essonnes, France, 91106
|Echirolles, France, 38434
|Lyon, France, 69003
|Orléans, France, 45067
|Paris, France, 75571
|Paris, France, 75651
|Paris, France, 75679
|Rennes, France, 35033
|Roubaix, France, 59056
|Rouen, France, 76031
|Saint-Etienne, France, 42055
|Strasbourg, France, 67098
|Toulouse, France, 31059
|Berlin, Germany, 10117
|Berlin, Germany, 14059
|Dresden, Germany, 01307
|Erlangen, Germany, 91054
|Erlangen, Germany, 91056
|Frankfurt, Germany, 60528
|Hamburg, Germany, 20251
|Hamburg, Germany, 22081
|Herne, Germany, 44649
|Hildesheim, Germany, 31134
|Koeln, Germany, 50937
|Leipzig, Germany, 04103
|Muenchen, Germany, 81541
|München, Germany, 80337
|Osnabrueck, Germany, 49074
|Ratingen, Germany, 40882
|Athens, Greece, 115 27
|Athens, Greece, 15121
|Crete, Greece, 71110
|Larissa, Greece, 411 10
|Thessaloniki, Greece, 54 642
|Thessaloniki, Greece, 546 36
|Thessaloniki, Greece
|Budapest, Hungary, 1027
|Budapest, Hungary, 1033
|Budapest, Hungary, 1036
|Debrecen, Hungary, 4032
|Eger, Hungary, 3300
|Gyula, Hungary, 5700
|Mor, Hungary, 8060
|Szekesfehervar, Hungary, 8000
|Szekszard, Hungary, 7100
|Zalaegerszeg, Hungary, 8901
|Ahmedabad, Gujarat, India, 380015
|Ahmedabad, India, 380009
|Bangalore, India, 560017
|Banglore, India, 560034
|Hubli, India, 580020
|Hyderabad, India, 500034
|Nagpur, India, 440010
|Ashkelon, Israel, 78278
|Beer Yaacov, Israel, 6093000
|Haifa, Israel, 34362
|Ramat Gan, Israel, 5262000
|Tel Aviv, Israel, 64239
|Napoli, Campania, Italy, 80131
|Napoli, Campania, Italy, 80144
|Telese Terme, Campania, Italy, 82037
|Arenzano, Liguria, Italy, 16011
|Genova, Liguria, Italy, 16132
|Bergamo, Lombardia, Italy, 24128
|Milano, Lombardia, Italy, 20162
|Varese, Lombardia, Italy, 21100
|Catania, Sicilia, Italy, 95124
|Firenze, Toscana, Italy, 50141
|Prato, Toscana, Italy, 59100
|Bauska, Latvia, 3901
|Daugavpils, Latvia, 5417
|Liepaja, Latvia, 3400
|Riga, Latvia, 1005
|Riga, Latvia, 1021
|Riga, Latvia, LV 1002
|Riga, Latvia, LV-1002
|Alytus, Lithuania, 62114
|Klaipeda, Lithuania, 92288
|Siauliai, Lithuania, 76231
|Vilnius, Lithuania, 06122
|Ipoh, Perak, Malaysia, 30990
|Kuala Lumpur, Malaysia, 68100
|Kuching, Malaysia, 93586
|Penang, Malaysia, 10990
|Selangor, Malaysia, 46150
|Selangor, Malaysia, 47500
|Chihuahua, Mexico, 31000
|Chihuahua, Mexico, 31238
|Ciudad Obregon, Mexico, 85000
|Cuernavaca, Mexico, 62270
|Culiacan, Mexico, 80000
|Delegacion Benito Juarez, Mexico, 03100
|Distrito Federal, Mexico, 06600
|Durango, Mexico, 34080
|Guadalajara, Mexico, 44500
|Guadalajara, Mexico, 45040
|Merida, Mexico, 97134
|Mexicali, Mexico, 21100
|Mexico City, Mexico, 06700
|Mexico City, Mexico, 14080
|Mexico Df, Mexico, 11850
|Mexico, Mexico, 03100
|Mexico, Mexico, 06100
|Miexico City, Mexico, 06700
|Saltillo, Mexico, 25000
|San Luis Potosi S.L.P., Mexico, 78240
|San Luis Potosí, Mexico, 78200
|Tijuana, Mexico, 22010
|Torreon, Mexico, 27000
|Amsterdam, Netherlands, 1056 AB
|Dordrecht, Netherlands, 3318AT
|Roosendaal, Netherlands, 4708 AE
|Schiedam, Netherlands, 3118 JH
|Cebu City, Philippines, 6000
|Iloilo City, Philippines, 5000
|Lipa City, Philippines, 4217
|Makati City, Philippines, 1229
|Bydgoszcz, Poland, 85-168
|Elblag, Poland, 82-300
|Krakow, Poland, 30-119
|Krakow, Poland, 31-121
|Lublin, Poland, 20-607
|Nadarzyn, Poland, 05-830
|Szczecin, Poland, 71-252
|Ustron, Poland, 43-450
|Warszawa, Poland, 02-118
|Warszawa, Poland, 02-653
|Wroclaw, Poland, 50-556
|Brasov, Romania, 500365
|Bucharest, Romania, 020475
|Bucuresti, Romania, 011172
|Bucuresti, Romania, 020983
|Cluj-Napoca, Romania, 400130
|Cluj-Napoca, Romania, 400349
|Iasi, Romania, 700127
|Iasi, Romania, 700656
|Ploiesti, Romania, 100337
|Sector 2, Romania, 020125
|Targoviste, Romania, 130083
|Targu Mures, Romania, 540142
|Timisoara, Romania, 300194
|Russian Federation
|Barnaul, Russian Federation, 656024
|Barnaul, Russian Federation, 656038
|Kazan, Russian Federation, 420097
|Kemerovo, Russian Federation, 650002
|Moscow, Russian Federation, 115093
|Moscow, Russian Federation, 115522
|Moscow, Russian Federation, 121374
|Moscow, Russian Federation, 123060
|Novosibirsk, Russian Federation, 630068
|Novosibirsk, Russian Federation, 630099
|Ryazan, Russian Federation, 390026
|Saratov, Russian Federation, 410002
|St Petersburg, Russian Federation, 194291
|Stavropol, Russian Federation, 355017
|Tomsk, Russian Federation, 634063
|Voronezh, Russian Federation, 394066
|Yaroslavl, Russian Federation, 150007
|Belgrade, Serbia, 11000
|Belgrade, Serbia, 11040
|Belgrade, Serbia, 11070
|Niska Banja, Serbia, 18205
|South Africa
|Cape Town, South Africa, 7925
|Diepkloof, South Africa, 1862
|Johannesburg, South Africa, 2193
|Pretoria, South Africa, 0002
|Merida, Badajoz, Spain, 06800
|Sabadell, Barcelona, Spain, 08208
|Torrelavega, Cantabria, Spain, 39300
|Santiago de Compostela, La Coruña, Spain, 15706
|San Sebastian de los Reyes, Madrid, Spain, 28702
|Málaga, Malaga, Spain, 29009
|Seville, Sevilla, Spain, 41071
|S. Cristobal de la Laguna, Tenerife, Spain, 38320
|Barakaldo, Vizcaya, Spain, 48903
|Castellon, Spain, 12004
|Madrid, Spain, 28007
|Vizcaya, Spain, 48013
|Antalya, Turkey, 07058
|Edirne, Turkey, 22030
|Erzurum, Turkey, 25050
|Trabzon, Turkey, 61100
|United Kingdom
|Birmingham, United Kingdom, B29 6JD
|Cambridge, United Kingdom, CB2 0QQ
|Cannock, United Kingdom, WS11 5XY
|Dudley, United Kingdom, DY1 2HQ
|Leicester, United Kingdom, LE1 5WW
|London, United Kingdom, E1 1BB
|London, United Kingdom, E11 1NR
|London, United Kingdom, SE5 9RS
|Newcastle upon Tyne, United Kingdom, NE1 4LP
|Salford, United Kingdom, M6 8HD
|Southampton, United Kingdom, SO16 6YD
|Westcliffe-on-sea, United Kingdom, SS0 0RY
|Wrightington, United Kingdom, WN6 9EP
Sponsors and Collaborators
Hoffmann-La Roche
|Study Director:
|Clinical Trials
|Hoffmann-La Roche
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on June 29, 2017
|Responsible Party:
|Hoffmann-La Roche
|ClinicalTrials.gov Identifier:
|NCT01331837 History of Changes
|Other Study ID Numbers:
2010-020065-24 ( EudraCT Number )
|Study First Received:
|April 7, 2011
|Last Updated:
|November 1, 2016
Additional relevant MeSH terms:
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Gastrointestinal Agents
Immunosuppressive Agents
Immunologic Factors
ClinicalTrials.gov processed this record on June 29, 2017


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I write to you all today with tears in my eyes, a heavy heart and a deep sadness. My dog Arthur has been sick with kidney disease which started last December. I am beyond crushed to report that as of last night he passed away peacefully while sleeping. I cannot believe I will never see him again and can hardly stand the sorrow of losing him. Please read Arthur's story, I am sharing his story mostly to honor him because he was such a wonderful dog that had such a bad start in life but provided more joy and love to me than any dog I have ever had. He was my sidekick and my companion through everyday of the last almost 15 years that I have had the privilege to have him. He made me believe in special gifts from god as he surely was one. Arthur is what brought me to the Rat Terrier ResQ because he was such an extraordinary little guy, I knew in my heart that I wanted to give other people a chance to have the experience of knowing these amazing, smart, funny, loving, loyal, beautiful and special breed. I am so proud to be part of this group and hope you will allow me to be forever. As the day has moved forward and through the never ending tears I have been planning ways to honor My Sweet Arthur. I hope to honor him everyday by loving my wonderful Lily whom I rescued through Rat Terrier ResQ. Although it was a rough start when I brought Lily home to meet Arthur, her charm and amazing spirit of love won him over and they truly loved each other. Lily will miss Arthur and my heart aches for her. As far as honoring my boy I am planning a memorial service for him and I am going to make a donation to the group in his name and will try to continue to give funds in the hopes that his donation will help to save lives of ratties that are in need. Please know that as much pain as I feel now it does not come close to the joy and memories I will have forever of My Sweet Arthur.
Today is a sad day for two reasons, the first one is that we had to say good bye to our cat Silver, he was been a member of our family for almost 17 years and even though everything told us that is was time to say goodbye as everyone knows it is still a hard thing to do. Silver was a very smart fellow and always showed us a great deal of affection and attention, unlike some other cats I have known. Our family has lost all three of our cats since 07, Chubber (age 18 +) we found him,pasted at the beginning of the year and Silver's brother Pistol passed on Oct 3,07. I miss them all and hope they are all together at the rainbow bridge.
The second reason we are sad is we had our hopes on adopting a new rattie that we meet through dogster, I found out today that he went to another home over the weekend and I am heartbroken. I understand why it happened since I am far away and a home was found locally and certainly I am happy for him to have a permanent home. I just felt a very stong connection to him as soon as I first saw his picture and I really thought he was going to join our family and be a kid brother to Arthur. I know there are are alot of dogs for adoption but this little guy was special and I will be sorry that I did not get him for a long time. I want to thank his foster mother for rescuing him from the cage he lived in for 4+ months and for taking care of him, so he could have a better life. Even though we never meet they will both in my heart.
was tagged by Cindy Sue to play this Valentine's Day Tag game...I'm supposed to list my 5 Valentine's Day wishes and then tag 5 of my pup furiends with a pmail or rosette. Copy & past the directions into your diary etc…here goes...
My 5 Valentine's Day Wishes:
1. I wish a very Happy Valentine's Day fur all my pals & furiends on Dogster
2. I wish that every pup in the world will have a loving home
3. I wish that every pup will have all the chewies, treats, & toys they could imagine
4. I wish mom would take me to work wiff her every day
5. And……..I wish Spring would get here!!!
Happy Valentines Day!!
My 5 pals I tagged are:
1. Cindy Sue
2. Tucker
3. Piper
4. Tia Lynn
5. Sparky
6. Maggie
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Jess Nixon
... Apr 2013
I'm not a fan of the whole "Keep Calm" thing, but this made me grin. I like the blue/red combo. It's cute.
view all »
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Rubio Returns to Florida
Published May 30th, 2012
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U.S senator Marco Rubio is back in the states after his first visit to Cuba.
The Florida republican toured the US Navy Base at Guantanamo Bay Tuesday.
The goal of the one day visit was to better understand how the facility plays a role in United States detention operations.
Rubio is Cuban-American, his parents originally coming here in 1956.
He says we should remember what those in Guantanamo are responsible for.
Rubio is a member of the senate intelligence committee delegation conducting oversight of Guantanamo Facilities.
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- Prosecutor Says Hakken May Be Faking Insanity
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- Woman's Swim from Cuba Cut Short


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There Are Two Ways You Can Obtain the New (2015) Version of Lightroom 1. Subscribe to Adobe's Creative Cloud subscription program, and get "Lightroom CC 2015". The most cost-effective version for photographers is the CC Photography Program, which includes Lightroom, Photoshop, and unlimited syncing of photos from Lightroom to Lightroom mobile for mobile devices, and to Lightroom web. The cost is $9.99 USD/month, and all future updates are included in the price. If you already are a CC subscriber, you can download the new Lightroom CC 2015 for free. I personally think that this plan is a great deal, but I realize that a subscription is not appealing to everyone. Note that you can also subscribe to the Complete Cloud, […more]
Find and Eliminate Duplicate Photos in Lightroom
In this video, I show you how I use Jim Keier's great Lightroom Duplicate Finder plugin to find and eliminate duplicate photos. I show you my workflow, give you tips and tricks along the way, and I show you the Lightroom skills you need to get the most from the tool. For best quality, hit Play, then click on the Youtube sprocket wheel in the bottom right and choose 720/HD. Table of Contents: 0:00 Introduction 1:07 How to First Back Up Your Catalog 2:06 Running Duplicate Finder 3:05 The Duplicates Smart Collections 5:30 Deleting Duplicates Directly from Folders 6:22 Flagging Duplicates for Deletion 9:48 Filtering to See Just Your Flagged Photos, Deleting Jim Keier's manual with installation instructions, and full […more]
Creative Inspiration and How-to: Using Your Camera as a Paintbrush
I generally don't review photography books on this blog, but I am making an exception to let you know about a book I have really enjoyed from Charles Needle, Impressionistic Photography: A Field Guide to Using Your Camera as a Paintbrush. If you're in a creative lull, or want to add more creative techniques to your repertoire that you can use in any light and that can turn ordinary compositions into beautiful art, you'll love this book. After covering equipment, Charles encourages you to play and experiment as he covers step by step how to shoot Multiple-Exposure Monets (a term he coined), Long-Exposure Slap Zoom, Multiple-Exposure Rotate & Zoom, Soft-Glow Montage, Composite Montage and many more techniques. Those that require […more]
View Your Focus Points with This Free Lightroom Plugin
With this free Lightroom plugin from Chris Reimold, we can view our in-camera focus points in Lightroom 5! According to Chris it works for all Nikon DSLR cameras and post-2002 Canon EOS DSLR cameras. It reads your camera focus metadata (focus points, distance, mode, etc), and displays the results in a separate window that opens. Click here to learn more about and download the Lightroom Show Focus Points plugin. You'll find that installation and using the plug-in are straightforward, and instructions are given on the site (as well as a full list of cameras supported, in the FAQ.) It works only in Lightroom 5, but a version for Lightroom 4 and earlier versions is in the works. The plugin is […more]
A Must-Have Lightroom Mobile for iPad Resource
Don't Miss Out on My Upcoming Fall Seattle Japanese Gardens Workshop with Charles Needle!
Join Charles Needle and me at the peak of autumn color in Seattle's beautiful Japanese Garden, October 25-26, 2013 . In this 2-day workshop, you'll learn how to capture fall colors in pleasing compositions that evoke the spirit of the Garden, and to bring out the best in your photos using Lightroom's Develop module. We will gain special early-morning access to the Garden before it opens to the public, from 7:30 am to 10 am on both days with the use of tripods, for a total of six private hours of shooting with your tripod! Charles, a professional garden photographer and workshop leader, will teach you how to best translate your creative vision into stunning imagery through lectures and lots […more]


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… 60 per cent of site visitors will watch a video first before reading the text on your site, landing page, or social channel. Want to increase engagement with your social network or web visitors? Produce some great videos to target and share with your audience(s). Salesforce has put together this great infographic with specifics on 7 places…


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Body cells detect signals that control their behavior through tiny hairs on the cell surface called cilia. Serious diseases and disorders can result when these cilia do not work properly. New research from UC Davis published this week in the journal Nature Cell Biology provides new insights into how these cilia are assembled.
"It's a basic discovery, but with implications for understanding disease," said Jonathan Scholey, professor of molecular and cellular biology at UC Davis and senior author of the study. Understanding how cilia are assembled and function can help scientists understand how conditions such as polycystic kidney disease and some growth and development disorders arise.
Cilia are built from bundles of microtubules made of a protein called tubulin. Scholey's team discovered how two subunits of tubulin are winched into place by a type of protein motor belonging to a family of proteins called kinesins.
Scholey's laboratory works with the soil roundworm Caenorhabditis elegans, whose cilia are essentially the same as those of humans and other mammals. Postdoctoral scholar Limin Hao, Scholey and their colleagues screened a collection of worms for those with mutations that affected the cilia.
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Fog Horn
by: United Cheddar • 59
All Android applications categories
by: United Cheddar • 59
Fog horn sound for kids and adults. Whenever your friend says something dumb, play the foghorn sound! You'll know the fog horn we mean when you hear it - its a classic.
Never miss a beat or let a joke go with the Virtual Fog Horn from United Cheddar. Play the fog horn sound at parties, or by yourself. The fog horn is fun for all ages.
Realistic fog horn sound, also known as a boat horn. Just shake your phone to play the fog horn, or press the giant button. Either one will activate your own personal fog horn.
We hope you like this fog horn sound app! For more fun sounds like this one, check out our other apps.
If you have feedback on this fog horn, or have a suggestion for a new fog horn sound, please let us know. If you have a fog horn and can record it for us, we'd be greatly appreciative.
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City Commissioner Craig Lowe to Run for Mayor
Published September 1st, 2009
Gainesville City Commissioner Craig Lowe is the first person to announce his candidacy for the office of mayor of Gainesville.
Lowe, who holds a Master's degree from the University of Florida, has served as a commissioner for six years. He was instrumental in pushing through the city's controversial transgender ordinance in January 2008.
Pegeen Hanrahan has been term limited as Gainesville's mayor, meaning a new mayor will be elected on March 16, 2010.
Related Stories
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Earnings from overseas visitors to Britain fell 12% to £9.4m in the 10 months to last October compared with the same period in 2000. The figures for November are expected to be as bleak.
Michael Dunkley, executive council member of the British Incoming Tour Operators' Association, said: 'Last year was a total disaster, to say the least. The figures for November will confirm what many of us already know. There are some hopeful noises being made about recovery from foot-and-mouth, but in the meantime I expect a number of coach and tour operators to go belly-up.'
The Association of British Travel Agents (ABTA) estimates that 16 tour operators and 20 travel agencies went bust last year, against six operators and 19 agents in 2000. Major travel groups such as Thomas Cook, Thomson and Airtours have also cut back, leading to thousands of job losses. And they have slashed the number of holidays available by 1m in an attempt to shore up prices.
The cuts in capacity represent an average reduction of 10%, though some have gone further. First Choice, for instance, has cut capacity by a fifth.
Keith Betton, head of corporate affairs at ABTA, said: 'Some destinations have been affected more than others. The number of people travelling to the Middle East, for instance, has fallen quite sharply and remains down, but there does not appear to be much reluctance to travel short-haul in Europe.
'There are fewer people travelling to Florida, a big tourist destination for Britons, but the Americans are proving more reluctant to fly internally so consequently prices of hotels and attractions in Florida are reduced.'
All the major travel companies are offering big incentives to attract holidaymakers. Lunn Poly, for example, has half-price holidays with no charge for children and free insurance.
Falling numbers of visitors to Britain have widened the country's already yawning balance of payments deficit on tourism. In the 10 months to October, the gap stood at a huge £12bn, against £9.3bn for the same period in 2000.
- More about:
- Florida
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- Thomas Cook
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Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.
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Photo Comments
It finally happened! We've got electrical up on the deck! Our new water dish keeps the water liquid even when it's freezing! The raccoons are so jealous. They'll be in tortor all winter while we are sipping our nice warm water. Big thanks to our friend Santos the cat who got his family to come over and put it in before his new baby human arrives.
I've been here 2 years now! It's so much better now that I'm super best friends with Chibi. No one can believe how he used to hate me. Unfortunately now Hannah is jealous of our boylove and she boycotts Chibi whenever he is hanging out with me. Which would be most of the day. I still sleep out in my shed in my little self-warming shelter and let them snuggle in the big house at night... Hopefully one day Hannah will warm up to me and she can see how snuggly I really am. With fur as plush as a cozy rabbit and a rumbling purr it's just silly to not have me in your cuddle shack!
Don't worry though. I'm at no loss for cuddles. Besides my "bromance" with Chibi the people can't resist petting me and I love it more and more. I guess now I'm more into being petted than some of their indoor cats! Who would have thought that shy little Mr. E would finally warm up to people and like being petted as much as Jigsaw?
I like being petted! I'm calm about it and would really get into it if Chibi weren't around to get jealous and come nip at me. I wish Jigsaw was still out here to help protect me. He's been inside for almost two weeks now! His leg was really mangled, and he's still not walking on it, but the doctor still doesn't think it's broken and is hopeful he will walk again since he can still knead his paw just fine and hold the bad paw off the ground when he limps. There is still hope he can come snuggle with me before Christmas.
Speaking of snuggling, I got my new shelter! Of course, Chibi won't let me use it on his deck... So they gave up and just put it in my shed. Extra wind and dog protection that way compared to being down on the patio. And it's nice because if I overheat I can get out and cool off just a little inside the shed. I'll make it through the winter okay.
I just need to keep trying to get Chibi to like me more. I try to be very submissive but he just keeps taking that as a sign to walk all over me, he doesn't seem to love me any more for it. Oh well. I know I'm a nice little boy. Jigsy loves me lots, and now my people get to pet me when they see me and I know that they love me, too.
Halloween 2007 has come and gone, and with it marked my one year anniversary from when I first showed up here after trick-or-treating hours in 2006. I stayed far away from all the crazy stuff the people were doing to celebrate, even though Jigsaw stuck around and says it wasn't so scary. Wow, a whole year in my new home, and how exciting it's been!
When I first showed up the people treated me so funny. They kept taking pictures and posting me on the internet for people who lost their cats to look for. They gave me special food and tried to get me to come up to them. They were just very insistent I must have a home somewhere. But they should know from their own feral cats over the years that just because a cat is homeless doesn't mean they have to look as ratty as my friend Chibi. Some of us are very healthy and take pride in our cleanliness. At any rate they kept fussing over me through the winter while trying to find an "owner" until one day Jigsaw showed up! Sporting the same exact bold swirly pattern as me on a very similar body type they knew he came from the same place. And when they examined him closely and saw he was ear-tipped so they knew we came from a managed colony! But unfortunately I was not ear-tipped so they still had to trap me and get me "fixed."
What a weird experience that was. I walked into this little wiry box to get some really yummy food and the door closed behind me, I couldn't get out! Then the humans came and got me and put me inside their house where I had to spend the night in this crazy little box. In the morning they picked me up again and put my "trap" into a bigger, moving trap called a car. It drove me off to an even stranger house, called a "vet clinic" with dozens of other cats who needed this "fixing" procedure. They knocked me out and did something weird to me and before they took me off their operating table they noticed I had a badly abscessed wound on my paw that I could have died from if they hadn't treated it then! How lucky! When they were done I was starting to wake up and they handed me to my human Lindsay. She gave me some medicines, cleaned my ears, and posed for a few pictures while I was still groggy enough to be held. Those crazy people. But I still needed more medicine for my paw, so when she took me home she had to make a bigger trap for me in her "garage" where I stayed for 10 whole days. It wasn't so bad. She waited on my all day giving me canned food and fresh water, even cleaning a little sandbox she gave me to do my business in. She only tried to pet me a few times and just gentle pats on the head, and finally my day of freedom came. She ushered me into yet another cage, this one smallest of all with a handle for her to carry me. Then she took me out to the backyard and let me go right in front of my shed. I was so happy, I plopped out and went right in. My friends were happy I was okay, and I was happy my paw didn't hurt anymore.
Since then things have been great. The Orange'n'whites are a lot nicer to me now and I trust the humans more. Every morning they feed me and lately I sit by the bowl when they pour my food. In fact, I've started smelling their hands and letting them touch me on my head without making a run for it. It's not so bad. I've yet to see why Chibi, Hannah, and Jigsy like it so much, but they insist some day I'll really like it, too.
So I've officially acclimated to my new home. This year's journey will be the journey of getting tame. I don't want to be the only one of 4 who doesn't love being petted forever, so wish me luck!
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This group is to be a resource and portal for nations, hospitals, clinics, investors, service providers and leisure venues who operate, look to operate or seek investment in the Caribbean basin.
Members: 16
Latest Activity: Jan 27, 2012
Started by Hilary Loftus. Last reply by Michael R. Brown Dec 23, 2009. 1 Reply 0 Likes
As the temperature drops in cold Connecticut, I am more an more interested in the state of medical tourism in the Caribbean. Does anyone here have an idea of what is going on in regard to the most…Continue


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Reviews & Stories
35 Year Old, Feel Like I Am 85 - 375cc Smooth Saline Submuscular Almost 13 Years Ago - Maumee, OH
First I must say, thank you to all the wonderful strong women on this site! You have all helped me without even knowing it! So here I am with my story. I have 375 mentor smooth saline, and they have been inside for 12+ years. I explant on 5/20!! Yay! I am sick. I have been on a slew of medication ever since implantation. The first was depression medication. I was healthy and young and fit... READ MORE
Recent comments from BellezaNatural
Whoa! It does sound very similar! And same skin tone too : ) READ COMMENT
Go with your gut! The biggest change in me is happiness. I can't explain it- my life situations are the same they have been. But I just feel so happy it's like I have won the lottery! Think about this, if you got a sliver in your... READ COMMENT
Thank you!! READ COMMENT
Yes I had capsules removed. My doc told me that removing the capsules would increase mortality during surgery! My quality of life was so pathetic before that it was a sacrifice I was willing to take. It sounds so sad to say that but... READ COMMENT
Yes!!! Every issue is gone!!! I even was "allergic" to the sun. I couldn't be out in the sun at all- I would get this rash called crystal milliaria (I am sure I spelled that wrong). That is completely gone! No more neuropathy no... READ COMMENT


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City concerned about flash flood filled with debris
Tuesday's meeting focuses on areas around Douglas Creek
COLORADO SPRINGS, Colo. - The city of Colorado Springs hosted a flash flood preparedness meeting for businesses and residents along North and South Douglas Creeks on Tuesday. Surrounding neighborhoods -- areas near Flying W Ranch Road, Centennial Blvd. and parts of Mountain Shadows -- were directly impacted by the Waldo Canyon Fire.
If a flash flood were to occur, the water would not be high and clear, according to Colorado Springs Division of Emergency Management. It would be fast-moving and filled with debris.
Bret Waters, director of the Emergency Management Division, told KRDO NewsChannel 13 that most people are not used to seeing the conditions the city could face.
The meetings are intended to inform residents of their risk and to plan accordingly. Representatives from the police department, fire department, Colorado Springs Utilities and emergency services were present.
"We want residents to be empowered with information," Waters said. "Really it boils down to individuals and families being prepared and having a plan."
Suzanne Metzger lives near Douglas Creek and attended the meeting on Tuesday. Metzger was evacuated during the Waldo Canyon Fire and found herself off-guard when the time came to leave.
"When we were evacuated before, I had a dog and she was left behind and it was really traumatic for me," Metzger said.
Metzger came to the meeting to find out what she can do to prepare for a flash flood.
Timothy Mitros, stormwater manager for Colorado Springs Public Works, talked about what the city is doing to prepare for flash flooding.
Because of the loss of vegetation over the Waldo Canyon burn scar, runoff potential is three to 10 times higher.
Mitros explained that the city has five debris catchments in place to help stop debris from flowing into neighborhoods. More catchments are in the works and each are expected to last for ten years.
The city is also doing aerial mulching in areas around Douglas Creek.
The public is encouraged to view maps online to determine their flood risk.


text: IMO this game should be still playing...The refs took 7 from the Seattle in the first qtr on a ticky tack call and then gave 7 to the Steelers on the Ben R phanthom TD. Only thing that crossed the goal line was his helmet. Was is the same ref thsat called both plays?? If so he should never ref a game again. Granted the 76 TD run by Parker and the flea flicker by Randay El to Ward were good legitimate scores, but that was the only 14 points they scored. Meahwhile, another bad holding call negates a pass to the 3 yard line by the Seahawks. The refs handed this one to the Steelers as they were not impressive in this game. The scores is 14-14 and we should be waiting for the nexy series of downs. The commercials were bad too.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
I am looking to hire an independent contractor ie writer, model that is outside the US. These individuals are located in UK and Canada. If I have them sign an agreement is it still enforceable?
Short answer: Yes (i.e., the fact that one party is outside the US does not make an otherwise enforceable agreement unenforceable).
Slightly longer answer: Yes, but, unless you are a multinational business, the process of enforcing an agreement against someone in a foreign country is so expensive and so uncertain of outcome that enforcement may not be practical.
This information does not constitute legal advice and does not establish an attorney-client relationship.Ask a similar question
This is a common question for businesses that hire across borders. In fact many (most?) businesses are using independent contractor relationships across borders.
This relationship can be great... or a big headache. If it's truly an independent contractor relationship under the foreign laws, then the employer gets the talent without the employer responsibilities. If foreign laws create an employer-employee relationship in fact, then the employer is on the hook for payroll withholding, employment law issues, corporate tax liability through a permanent establishment, and corporate registration issues: a nightmare!
All that said, the UK and Canada are relatively easy to troubleshoot. I've helped businesses with independent contractors and employees in both jurisdictions.
In short, you'll want to determine the factual--an in turn legal--nature of the relationship. This will let you know your risk as an employer. I can walk you through that analysis in a short phone call.
Now, if you are asking whether the terms of the agreement are enforceable, it generally is in Canada and the UK--especially if you have a well written agreement that complies with local laws in Canada and the UK. You'll want to include some practical terms in contract and thoughtfully consider how you structure the relationship from a non-legal perspective.
If you are interested in chatting further, please feel free to email me (firstname.lastname@example.com) or call me (+1 425 351 9455) directly. While you might be able to figure out this information on your own, it would not hurt to go through a free consultation to point you in the right direction.
Total Mobility Law is an international law firm that lets companies do global business with the knowledge and confidence they need to comply in any country. Our answers on this site do not constitute legal advice, nor do they establish an attorney-client relationship. The only thing that can do that is a signed Engagement Letter and Fee Agreement, which you can get by contacting us through www.totalmobilitylaw.com.Ask a similar question
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Kronos is used by biweekly-paid regular staff, temporary employees, and student employees to log hours each pay period. Monthly-paid staff, librarians, and postdocs use Kronos to record vacation, sick, and other leave time each month.
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Welcome to the sixth edition of the International Music Festival of Navarre (FIMNa), which brings together professional musicians from all over the world for a week of playing and sharing music in a place of great beauty, Eugi, in the Esteríbar Valley, Navarra (Spain).
After these first five years, we return to Eugi this Summer full of energy and excited to share our music with an already loyal audience, which grows from year to year. In the 2013 edition we will once again extend our activities to the neighbouring village of Zubiri, where one of our concerts will take place.
In addition, the children of Eugi and of all of the Esteríbar Valley will be ale to enjoy the music and have a leading role in the Festival, participating in FIMNa in the Community's music workshops as well as in the final concert. We return this year with artists from different corners of the World, who will perform a varied programme that we hope will entertain, provoke and inspire our dear audience. These artists include Austrian flautist Vera Klug who will share the stage with German guitarrist Yvonne Zehner, and Spanish tenor Julio Morales. We welcome once again the talented Navarrese harpist Alicia Griffiths, whose career is taking off outside our frontiers, and we present our audience with Latvian pianist Inese Klotina. We are determined to continue supporting the composition and interpretation of new works, with the premieres in Spain of several pieces by Swedish Composer Karl Niklas Gustavsson, and the World premiere of a violin and guitar duo by English composer John Barber, as well as three new Basque songs arranged by Francisco Javier Jáuregui.
Our FIMNa in the Community Project will provide an energetic, unique and vibrant finale to our festival this year, with the Brazilian rhythms of the versatile percussionist Adriano Adewale, which will inspire the children of Eugi and the Esteribar Valley to reach No Corazao do ritmo, The Heart of Rhythm.
We invite you to continue enjoying this adventure of exploring our human culture through one of its most universal, visceral and at the same time sublime languages, music, in the beautiful natural and historical setting of Eugi.
The Council of Eugi and Elena and Francisco Javier Jáuregui, Festival Directors


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In NM, where open carry is legal, yes.
This is a discussion on Carrying in the car? within the Concealed Carry Issues & Discussions forums, part of the Defensive Carry Discussions category; When you have a coat on to cover the gun and you get into the car to go somewhere,can you take off the coat and ...
When you have a coat on to cover the gun and you get into the car to go somewhere,can you take off the coat and expose the gun on you're hip while driving?
And is it legal?
If open carry is legal then yes you can. I usually open carry in my car because the gun sticks to my skin and annoys me.
Who's going to see it anyway ? Just cover it up when you get out.
If Kansas is an open carry state then yes! if its not then I'ed say no! Minnesota it ok both ways..
Better to have and not need then to need and not have!!!!
EDC G22+Clips=SECURITY
I found my answer but this might help others.
************************************************** ********
"Open Car Carry Firearms may be openly carried in cars without any license except where localities have made open carry illegal; however, concealed handgun permits accepted by KS make the holder exempt from all local open carry bans. "
This is for Kansas.
Excellent. Personally, I'm concealed 100% of the time, even though MN is good either way. Yes, it takes a bit more effort, trial, and (we hope not) error.
Liberty, Property, or Death - Jonathan Gardner's powder horn inscription 1776
Tu ne cede malis, sed contra audentior ito.
("Do not give in to evil but proceed ever more boldly against it.")
-Virgil, Aeneid, vi, 95
In MO vehicle carry may be open or concealed no permit required.
In Texas, it must be concealed all the time. No open carry law...
"Texas can make it without the United States, but the United States can't make it without Texas!".... Sam Houston
Retired LEO
Firearms Instructor
NRA Life Member
In Michigan you can open carry, but when you step in a car you are now "concealed" and must have a CPL.
John VanDusen
"Whether it's a football game or an IED attack, you play EXACTLY how your practice."
"Put your trust in God, and keep your powder dry." ~Oliver Cromwell
In Michigan, you must have a CPL. Open carry is legal, but as soon as you step foot into a vehicle, it's considered concealed.
If you don't have a CPL, you must put it in the trunk and separate it from the ammo. Many diehard OCers get a CPL only so they don't have to go through this hassle.
I like MO for the no permit reasons for OCing.
But the age of 23 to CC kind of sucks....


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Conversion Is Not An Outreach Strategy
By David Ellenson, Kerry M. Olitzky
Big Tent Judaism / Jewish Outreach Institute (JOI), Forward Association, May 12, 2006
The authors assert that merely advocating for conversion is not an adequate strategy for outreach.
Topic: Intermarriage, Conversion, Outreach, Identity Formation
Name of Publication: Jewish Daily Forward
Genre: Newspaper
Coverage: United States
Language: English
Copyright Holder: Author
Copyright Information: Download for personal use; Distribute link freely
Bibliographic Information:
Ellenson, David. Olitzky, Kerry M. Conversion Is Not An Outreach Strategy. Jewish Daily Forward. Big Tent Judaism / Jewish Outreach Institute (JOI),Forward Association. 12 May 2006: http://www.bjpa.org/Publications/details.cfm?PublicationID=4668
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Tuesday, November 27, 2007
Drifting Back To Steelhead Fishing 35 Years Ago
People who just started steelhead fishing in the last few years missed out on the finest fishing ever seen back in the late 1960s and early 1970s. Good numbers of fish were being planted all around the state, and the Betsie and Platte rivers offered great sport that was as good as it gets.
There was some natural steelhead reproduction 35-40 years ago, and the DNR was planting fish as well. The number of anglers who knew how to catch steelhead were few, and the numbers of fish were very high.
My guiding career began in 1967, and brother George joined me in guiding fly fishermen for salmon, steelhead and broad-shouldered brown trout. John McKenzie became the third of Tres Amigos, and we cut a wide swath through runs of spring and fall spawning salmon and trout.
Snagging was rampant in those days, and we fished with No. 4, 6 and 8 single-hook flies, and it may sound like bragging but it's not: we were good anglers and guides, and there was no need to snag fish. We could fair-hook fish on a regular basis. The sheer numbers of fish meant if we spooked fish in one spot, a short distance away would be other willing fish.
The steelhead runs were huge in the late 1960s and early 1970s, and I can remember days on the Little Manistee River when we could hook 30 steelhead in a day. Not all fish were landed, but George and John tied flies while I handled the bookings for three guides.
We were a busy bunch, and were on the river every day. We knew where the salmon, steelhead or browns would be from day to day, and we seldom had much competition. We came and went, and sometimes Tres Amigos were all on the same stream, and at times we would be spread out across three different rivers. We'd compare notes at night, and decide who would fish where the next day.
John, 13 years younger than George and I, was a good-looking guy. I often paired him with husband-and-wife teams or father-and-daughters, and his great talent—besides catching fish—was being able to teach people how to fish. He was patient, and clients easily learned from him.
George and I were older, and by nature, seemed to attract the older anglers or the chief person who brought a crew up fishing. We treated everyone the same; we'd fish from sunup to sundown every day if clients wanted it, and clean fish at night and be up early the next day and ready to go again.
Guiding fishermen was a way of life for Tres Amigos, and we were very good at what we did. We could spot fish, coax anglers into putting the fly in exactly the right spot so it would be scratching gravel when it passed the fish. Often the fish would take, and we'd have a big fight on our hands.
One thing captivated the three of us: putting people into big fish for the first time. The smiles that crossed their faces when they fought a 15-pound steelhead for the first time; got hooked into a 30-pound Chinook salmon; or was trying to land a big hook-jawed male brown trout weighing 12 to 18 pounds. It's been many years since those faces broke out into a smile, but I vividly remember most of them.
There wasn't anything we wouldn't do for each other. John was known to tie flies by hand on the river bank when we ran out. George was always there to coax anxious anglers into following a big fish downstream, and I was the guy that made it all work with the precision of a Swiss watch. All of us had a job to do, and we greeted each peach-colored dawn with a smile on our face and a jump in our step.
For 10 years we were Tres Amigos—three friends—who made a living in the best possible way—being outdoors, on the river, and with a client holding tight to a big fish jumping in the river.
We often went without eating, found ourselves upside down in the river current trying to net a client's fish for them, and we looked out for each other. We also paid attention to our clients, catered to their every wish that was ethical and legal, and we coaxed more out of our client's skill levels than they knew they had.
We put people into fall-spawning rainbows that had tiny tails, fat waists, and a 23-inch fish that weighed 13 pounds. The browns, especially the big males, were a golden-bronze with big spots; the steelhead were mint-silver and high jumping; the Chinook salmon were tackle busters of the first degree, and some mighty battles would cover a half-mile of river. The coho salmon were seldom finicky about a fly: put it to them at their level, and they would hit.
It was a magical 10 years, and now brother George is gone. John McKenzie talk all too seldom, and when last we spoke, we took a trip down memory lane. We were there for the finest salmon and trout fishing this state has ever seen, and pride ourselves on being the first fly-fishing river guides.
And that, my friends, is something we'll never forget.
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Paul Tucker is standing down as Deputy Governor of the Bank of England, it was announced today.
Tucker was said to have narrowly lost out in the race to be the next Governor of the bank to Canadian Mark Carney who takes up his post at the start of next month.
News that Tucker is leaving before his term ends next year immediately led to speculation that he will enter the world of commercial banking with Royal Bank of Scotland and Lloyds Banking Group looking for a new chief executive and new chairman respectively.
Tucker said that he plans to head for the United States where he will take up a position in academia.
However, bankers pointed out that both jobs could be available for some time with Lloyds chairman Sir Win Bischoff not due to retire until May 2014 and RBS chief executive Stephen Hester prepared to stay on until the end of this year.
The Bank said no date had been set for Tucker's departure and that he would remain in post while Carney settles into his new job and would probably leave in the autumn.
Outgoing Governor Sir Mervyn King said: "Paul's contribution to the Bank, to monetary policy, and more generally to public policy, both in the UK and in the world as a whole has been enormous."
Tucker said: "It has been an extraordinary honour to serve at the Bank of England over the past 30 years. I am very proud that, through the Bank and the wider central banking community, I have been able to make a contribution to monetary and financial stability. I will continue to do so in the coming months."
Many City people put Tucker's failure to get the top job down to his correspondence with Barclays chief executive Bob Diamond who was forced to resign over the Libor-rigging scandal.
Tucker paid tribute to Diamond as "an absolute brick" during the financial crisis in correspondence in December 2008. He was responding to a message from Diamond in which the Barclays boss, then head of the investment bank, congratulated Tucker on his appointment as deputy governor.
Diamond wrote: "Paul, congratulations. Well done, man. I am really, really proud of you. Talk soon." Tucker replied: "That's so much Bob. You've been an absolute brick through this."
Andrew Tyrie, chairman of the Treasury Select Committe, told Tucker "It doesn't look good, I have to tell you" referring to the exchange with Diamond.
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I have a touch screen kit that was previoulsey installed in a tm-701 monitor that I am looking to sell. It has a usb interface, and is in great condition. There are no scratches on it that I can see. I have the original driver cd. I bought this kit from Digitalww, and no longer need it. I used it for less than 6 months. I am asking $75, but will take offers as well.
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Salmon with Dill Sauce & Lemon Risotto RecipeRead Reviews Be the first to add a review
- 1/2 cup mayonnaise
- 1/4 cup sour cream
- 1 tablespoon chopped green onion
- 1 tablespoon lemon juice
- 1-1/2 teaspoons snipped fresh dill or 1/2 teaspoon dill weed
- 3 to 3-1/2 cups chicken broth
- 2 tablespoons olive oil
- 1 shallot, finely chopped
- 1 cup uncooked arborio rice
- 1 garlic clove, minced
- 2 teaspoons grated lemon peel
- 1/4 teaspoon pepper
- 4 salmon fillets (6 ounces each)
- 1/2 teaspoon salt
- 1/4 teaspoon pepper
- 2 tablespoons olive oil
- In a small bowl, mix sauce ingredients. Refrigerate, covered, until serving.
- In a small saucepan, bring broth to a simmer; keep hot. In a large saucepan, heat oil over medium heat. Add shallot; cook and stir 1-2 minutes or until tender. Add rice and garlic; cook and stir 1-2 minutes or until rice is coated.
- Stir in 1/2 cup hot broth. Reduce heat to maintain a simmer; cook and stir until broth is absorbed. Add remaining broth, 1/2 cup at a time, cooking and stirring until broth has been absorbed after each addition, until rice is tender but firm to the bite, and risotto is creamy. Remove from heat; stir in lemon peel and pepper.
- Meanwhile, sprinkle fillets with salt and pepper. In a large skillet, heat oil over medium heat. Add fillets; cook 6-8 minutes on each side or until fish just begins to flake easily with a fork. Serve with sauce and risotto. Yield: 4 servings.
Full-Bodied White Wine
Enjoy this recipe with a full-bodied white wine such as Chardonnay or Viognier.
Reviews for Salmon with Dill Sauce & Lemon Risotto
"I added extra lemon zest and also lemon juice into the risotto. I also preferred the fish without the dill sauce. But still a very tasty dinner!"
"Fabulous recipe. Salmon so easy to make; risotto so much healthier than another version that I make with butter and a ton of Parmesan....the lemon was just right!! I'd make this for company in a heartbeat."
"Excellent recipe ! I used all sour cream intead of mayo. I also used chopped capers in the sauce. Very quick and yummy recipe !"
"The sauce is great with the salmon! I substituted ground dried lemon peel for the fresh peel in the risotto, however, and this was NOT a good thing. Next time I will definitely make it as written."
"easy to make and very good. I also baked the fish, and it was great."
"This was delicious and so quick/easy to make. I added a little bit of lemon juice to the risotto just to give it a bit more flavor. I cooked the salmon in the oven instead of on the stove. Brushed each filet with a little bit of olive oil, sprinkled salt and pepper on top and baked it at 425 for about 10 mins. The dill sauce was wonderful. (I added lots of extra dill)."
"I normally don't like salmon but this was great!"
"My husband and I try to eat fish at least once a week. I'm more of a seafood fan than he is. He said this was the best fish I've ever made him. The ingredients tasted so fresh together! I didn't pan fry the fish however, I baked a full salmon at 350 for about 15-20 minutes."


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High-spatial-resolution magnetization maps of ferromagnetic surfaces are generated with use of scanning electron microscopy with polarization analysis (SEMPA). The structure of surface Neel walls is measured by SEMPA and compared directly to the results of micromagnetics simulations. We find that the surface magnetic properties observed with SEMPA can be modeled using standard micromagnetic theory using only bulk parameters. Surface-domain-wall magnetization profiles were measured, using two different probe diameters in each case, for an Fe(100) single crystal and for Permalloy films with thicknesses of 0.12, 0.16, 0.20, and 0.24-mu-m. In making the quantitative comparison to the surface-domain-wall profiles calculated from (bulk) micromagnetic theory, the rms deviations, the chi-2 statistic, a correlation statistic, and rms deviations at 5% and 95% confidence levels were determined for each case. The calculated and measured domain wall profiles agree on the average to within +/- 7.8% for 180-degrees walls in semi-infinite crystals of Fe(100), and +/- 4.5% for 180-degrees walls in thin films of Permalloy. The micromagnetic simulations show the 180-degrees wall of the bulk turning over into a Neel wall at the surface with the magnetization in the plane of the surface. The Neel wall extends from the surface into the bulk over a depth approximately equal to a Bloch-wall width.
Citation: Physical Review B (Condensed Matter and Materials Physics)
Volume: 43
Issue: 4
Pub Type: Journals


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Out of curiosity... anyone ever CC while in uniform? Did that change after the Carson City IHop shooting?
I may be missing something in the regulations, but I haven't found anything that specifically addresses it.
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Out of curiosity... anyone ever CC while in uniform? Did that change after the Carson City IHop shooting?
I may be missing something in the regulations, but I haven't found anything that specifically addresses it.
The only time CC is allowed in uniform is when required by mission or duty requirements.
I am retired now so I do not have any of the regs available but when I was on active duty we as aircrew were required to carry concealed weapons for anti-hijacking purposes. The only time we open carried was when transporting the big mothers that really go bang (nukes).
AFAIK off base there is no regulation against carrying a lawfully concealed firearm,On base is a different animal
Come on J just get authority and OC , and keep your "hat" on......
Of course back in our day, the wear of the uniform off base was more tightly controlled. To and from work with only stops for fuel. No Walmart, McDonald's (other than drive thru), no grocery stops.
There was a bill introduced in Congress on this very topic that appears to have gone nowhere:
S.3388: Service Member Second Amendment Protection Act of 2010 - U.S. Congress - OpenCongress
This must have gone somewhere because I got a message about a month ago that included a lot of new provisions that were included in this bill.
I'm away from the desk right now so I don't have it. I'll try and remember to look it up.
Still can't carry on post though.
I'm a 19 year active duty sailor. This question has been brought up several times during my career. At every place I've been stationed, the regulations have been the same, give or take a few words. Mostly these regulations have been listed/posted at the base/duty station level (I have yet to find where it written at a service/DOD level) BUT the 'loop-hole' regulation almost always cited is found in the uniform regulations ( Uniform regulations:1401-3-1-d-e)and in the laws concerning having a standing army (or any branch of service) armed while on American soil. The simple answer is no, it is not allowed.
While in uniform, on or off duty, you are a direct representive of your country, service, base, and command. Being armed in uniform is aginst the law as per the constution ( although the Defense Authorization Act of 2007 lifted some of the restrictions of the POTUS to deploy soliders on US soil......I think). Regardless, unless authorized by authority highr than just the unit commanding officer, even concealed carry is not authorized in an off-duty status.
This has been my experience. If someone has more insight and/or diffrent authorizations, please lemme know as well. I'm personally all for carrying in uniform.
There have been a few CGs that had policies restricting their personnel, but there is no wide spectrum restriction.
I am an active duty Captain and Troop Commander. I CC all the time off post. When I come on post I have to clear and lock my weapon. I can secure it in my vehicle at the office or take it home (I live on post).
EDIT: Of course we are talking about personally owned weapons here. An issued weapon, for guard duty lets say, can not be CC, or used for any unofficial purpose.
This subject has been directly quoted during a couple of my 'base check-in's' as a no-no....... i.e. some base commanders forbid the carrying any firearm in uniform while off base and off duty.
Again, I'm for it. Being told no is a definate let-down though.
I understand we're talking CC'ing while in uniform. I CC off post in uniform. Unless your commander or CG (Admiral, in the Navy I guess) says specificaly "no" then you are good to go.
I just did a quick search and I'm starting to think it will be just like your CC permit -- it will vary state by state. Florida does seem to care; Georgia does not seem to care. So I'm not sure there's an easy answer to this one.
I've carried off base, in uniform...without a problem. No AFI preventing it.


text:
Kirkwood, MO, USA < change city >
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College Church is an amazing place to be married. We went to school at SLU so we ...
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4344 Shaw Blvd
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The garden is not only a well-known St. Louis landmark, but a beautiful backdrop ...
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Cannot beat what you get for their price. We also had McArthur's bakery, famous ...
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The Ritz Carlton in St. Louis is always a wonderful option for not only your out-...
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AMAZING venue! The ballroom is beautiful! No need to decorate... the room has cha...
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St Louis, MO, US
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Breathtaking. Everyone kept commenting how perfect the setting was. We hear, th...
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This church as sentimental meaning to us, since my husband went to grade school h...
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Beautiful and simple non-denomenational setting. Their staff is extremely helpfu...


text: Jeffrey R. Young Jeffrey R. Young is the technology editor for the Chronicle of Higher Education and author of the e-book Beyond the MOOC Hype: A Guide to Higher Education's High-Tech Disruption. Future TenseApril 23 2014 12:21 PMThe Student Becomes the TeacherWhat MIT learned from a Mongolian teenager who aced a MOOC.Jeffrey R. Young Future TenseNov. 6 2013 5:32 AMThe New Rock-Star ProfessorShould celebrities teach online classes?Jeffrey R. Young


text:
Toronto could hand Bombardier a "signature" contract
By Leah Schnurr
TORONTO (Reuters) - Bombardier Inc appears poised to win a major contract to replace Toronto's fleet of streetcars, highlighting the growing global demand for the plane and train maker's light rail vehicles.
The contract, worth C$1.25 billion ($1.7 billion) for 204 new streetcars, is expected to go to the Montreal-based company after Germany's Siemens AG decided not to enter the bid.
Given growing concerns over pollution and congestion in major cities around the world, the light rail segment is likely to have long-term growth potential for Bombardier. It is already the world's No.1 provider of light rail equipment with customers in Europe and North America.
"It's green, it's politically correct," said Jacques Kavafian, analyst Research Capital, of the transit division, "It's got the whole environmental thing written on it, so I think it's going to be important."
The potential contract has an option for purchasing up to an additional 364 streetcars over the next 15 years, as part of a plan to expand the use of light rail and rapid transit across Toronto.
A spokesman for the TTC was unable to give a total value of the contract should the option be exercised, but a report in the Globe and Mail newspaper put the value at more than C$3 billion.
David Slack, a spokesman for Bombardier's transportation division, said the deal could stand as a "signature" contract for the company as Toronto is an important city for mass transit in North America.
"In terms of positioning ourselves as the leader of light rail vehicles in the world, it's very important in that regard," said Slack. Continued...


text:
Converting my 125 gallon planted tank to a ....
Well, here's the old set up. A planted tank with CO2. The works.
Aquascaping thread on another foumr :icon_roll
now for the ....
I want to do what I think is called a Vivarium.
I hope to turn this into my "offical planning thread". Maybe I'll move it to the vivarium forum once I decide on this.
What I want to do is take may 125 gallon tank which has a 5'x2' footprint and make it approximately half water. The tank height is 20", so 10" will have water in this case. I'd bascially make a slope with the substrate from deep water till it hits land. So, half half of the water will make the water area about 20-30 gallons. I'm hoping to get closer to 30" water. Maybe an island in the middle of it via driftwood. I plan on having some smaller fish in there (neons, etc). I also want land animals. Maybe frogs. Maybe not. Something that won't eat my fish and won't try to escape.
I plan on using glosso as ground cover in the water. Land plants are TBD.
Some kick off questions.
1) I will have to go with an overflow for this, corrrect? After all, I need to maintain the water level. Easy enough.
2) Due to (1), I also have to go with a sump, correct?
3) Is there a site that can recomend land animals? Something unique would be nice.
4) Is this possible to do in a low maintnenace manner? That's part of the reason I am going with glosso for ground cover in the water. it's also part of the reason I want to change my tank from a planted tank to something else. Besides. I need a change. The animals arn't the issue. I juut don't want to spend alot of time trimming plants. Feeding animals is hte easy part ;) I might also do some crpyts under water.
I might start work on the new setup VERY soon. Possibly tommorrow night if I buy the sump. I just ned a kick in the pants from you all ;)
PS: I've been planning this for a while. I thin it's time I take the step of ust doing it ;)
QUESTION) Can I simply use my substrate from the aquarium to form the land area? That was my presumptious plan. It's a 40/60 mix of fullers earth and something I can't recall. It's 0% fullers earth though, which is basically potting soil (but not soil).
Hey Karl, good luck with that! I can't offer much help since I have never tried something like that, but I was very inspired by this article:http://badmanstropicalfish.com/vivarium/vivarium.html and one day I will have time, energy, money, and room to set up something like that! Maybe in 35 years :icon_roll
Anyway... I think you can use aquatic substrate for the terrestrial part. I assume you want to plant the land part... then it would be something like hydroponics, where you have the plants growing in gravel, fullers earth, whatever, and you either wet it every so often, or the water is collecting on the bottom for the roots to access.
Let us know how things turn out!
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In an attempt to fight "spinsterhood," the Egyptian Bank for Development and Agricultural Credit [2]decided to grant loans to new farmers to encourage polygamy.The Bank's chairman, Mohsen Batran, announced in a press conference held with the Minister of Agriculture on Tuesday, that the bank will be granting loans to young farmers, to help them with the cost of marriage, [3] according to "al-Ahram" newspaper.His initiative includes encouraging polygamy, [4] provided that they will just wed two wives. The bank's chairman said that the loan's interest on the first marriage is three percent while for the second marriage is six percent. Men seeking a third wife will have to pay a loan's interest of more than 15 percent.According to Al-Ahram newspaper, there are nine million unmarried women in Egypt. [5]Batran, meanwhile, criticized those who are skeptical about the bank's support to the farmers, adding that the bank had helped 37 thousand farmers with their debts.
What do you think of this story? Should new farmers in Egypt be encouraged to have more than one marriage? Or is the loan a bad idea? Share your comments with us below!
[1] http://www.syndigate.info
[2] http://www.ruralfinance.org/library/agribank-statistics/agribank-statistics-details/en/?no_cache=1&srec=12934&tdet=training&tdet2=&tdet3=10&referer=MTAxODE%3D
[3] http://www.albawaba.com/editorchoice/yemen-women-marriage-437392
[4] http://www.albawaba.com/editorchoice/saudi-multiple-marriage-452130
[5] http://www.albawaba.com/news/egypt-atheism--461206
[6] http://www.alarabiya.net/english


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Teens Confess to Deer Poaching
Two Clarke County men pleaded guilty on Nov. 8, to using a rifle to kill four buck deer, removing the heads and leaving the remains in the field in Lucas and Clarke counties.
Cody Wright, 18, confessed to killing three bucks and Brian Pollard, 19, confessed to killing one. They were each charged with wanton waste of deer, taking a deer with a rifle and illegal transportation of deer.
Wright was assessed $435 in fines and $8,000 in liquidated damages. Pollard was assessed $435 in fines and $4,000 in liquidated damages. The DNR seized four sets of antlers and two rifles.
Pollard will perform 80 hours of community service to reduce his liquidated damages by $2,000. Wright will perform 160 hours of community service lowering his liquidated damages to $4,000.
The men requested a hearing to have their rifles returned.
I'm not even sure what
Submitted by hunter25 on Sun, 2011-05-15 22:51.
I'm not even sure what liquidated damages means but it does not seem that the penalty is all that severe once again for poaching. I wonder how these kids were brought up to show absolutely no respect for the animals they were killing. It's not just that they killed illegally but did not even recover the meat. That is as bad as it gets and they should not be able to hunt for a very long time to drive home the seriousness of what they did.


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Studio 360
Forty Years of Doonesbury
After four decades, cartoonist Garry Trudeau is still creating the Doonesbury comic strip. He tells Kurt his Vietnam-era strips were a counterculture fantasy, and what he most wants in his present-day depictions of the lives of injured Iraq War veterans is to get it right.
VIDEO: the Doonesbury characters speak!
Music Playlist
Strip CartoonArtist: Jethro TullAlbum: Too Old to Rock 'n' Roll: Too Young to Die!Label: Capitol
Mother Nature's SonArtist: Harry NilssonAlbum: HarryLabel: DCC Compact Classics
Improvised Ode to the UniverseArtist: Reggie WattsLabel: Recorded Live in WNYC's Jerome L. Greene Performance Space


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Red Sox vs Orioles Odds 2011 MLB Predictions
American League East rivals Boston and Baltimore continue their three game set this evening as the Red Sox look to even the series at a game apiece. The Orioles, which took last night's opener 4-1, will send veteran Jeremy Guthrie to the hill. Boston will counter the Stanford graduate with Josh Beckett. Tonight's game is scheduled to get underway at 7:05pm ET at Oriole Park at Camden Yards. The latest MLB Odds have the Red Sox listed as a -150 moneyline favorite; the game total is set at eight with the Over drawing -120 odds.
Boston saw its five game win streak come to an end last night after Baltimore rookie Zach Britton held the team to five hits and one earned run over six innings. The Red Sox Clay Buchholz, who once hurled a no-hitter against the Orioles, got battered for 12 hits and four earned runs in the 4-1 loss.
Veteran Josh Beckett will attempt to outperform his fellow starter this evening as he looks to increase the gap between Boston and the AL East cellar. The Red Sox, at 10-12, currently hold a half game lead over the fifth place Orioles. Neither squad is too far out of the race, though, with Baltimore just 3.5 games back of the first place Yankees.
Beckett, who is 6-3 lifetime against the Orioles with a 3.53 ERA, has been dominant through four starts this season. The Spring, Texas native is 2-1 with a 1.93 ERA and 0.79 WHIP, but his numbers are even more impressive if one removes the totals from his first outing of the year. Beckett has allowed a meager eight hits, three earned runs, and five walks (24 strikeouts) over 23 innings since losing 3-1 at Cleveland on April 5th.
Jeremy Guthrie has also pitched well this season, with his only bad start coming against the Indians as well. Guthrie gave up 10 hits and six earned runs over five innings in a 3-8 loss at Cleveland on April 16th. Outside of that performance the 32 year old right hander has given up 14 hits, three earned runs, and two walks in 21 innings.
Guthrie's best work from the mound has seldom been featured opposite the Red Sox. In 15 career appearances against Boston, Guthrie has produced a 1-7 record to go along with a 4.94 ERA and 1.63 WHIP.
These two rivals spilt the season series last year with both teams garnering nine wins. Last night's loss represented Boston's sixth in its last 10 games at Camden Yards, though.
Red Sox vs Orioles Odds 2011 MLB Predictions:
Boston Red Sox -1.5 (+105), Over 8 (-120), -150 (Moneyline)
Baltimore Orioles +1.5 (-125), Under 8 (+100), +130 (Moneyline)


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Topics List
Grackle or Blackbird?
(5)... They absolutely do. As previously mentioned, gloss on nearly any species bird becomes difficult or impossible when the sun isn't shining on the bird. ...
Chuck & Lillian
Jun 22
Continuing Long-tailed Jaeger, Bridgeport Reservoir, Mono Co. 6/19
(3)I was with Peter Metropolis when the bird was found. We were extremely lucky that it flew right by us not 20 feet away, after many distant looks. It is a
Sally Walters
Jun 20
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Basement Cinder Block Crumbling
I live in a house that I believe was built in 1948. The basement walls are cinder block. I have areas of the walls that are stained and some areas that are crumbling. Some spots are bubbled and easy to push in. Not sure if it's the cinder block and/or the paint the previous owner used. When I moved in I was told there was a water problem in one corner and it had been waterproofed. I believe the waterproofing was done right because I don't really notice any new damage or worsening issues to the walls since I've been there. Most of the issues are in that corner but there are some other spotty areas. Most of the spotty areas seem to be confined to the base of the wall. My question is I want for now to just paint the walls to make it look nice. How do I go about preparing the wall to paint? Do I scrape as much of loose material off the wall as I can and then use some sort of sealer/paint? Any help would be greatly appreciated, Thanks.
would've been nice to see your area listed under your name so we'll guess northeast,,, cinder blocks never were a good material for most foundation walls but cheap compared to conc,,,compressive strength was fair enough to support most bldgs but the main problem was the lack of waterproofing on the exterior,,, not that anyone properly waterproofed exterior conc walls either but concis more resistant to wtr damage than cinder blks,,, hell, even conc blks are better,,, anyways, wtr runs downhill ( especially thru the loose backfill alongside fnd walls ),,, that backfill was never compacted properly for 3 reasons: 1, cinder blk walls don't have the lateral strength to resist compaction force; 2, wasn't rqd by code; & 3, cheap bldrs,,, that wtr dissolves soil's acid salts which then attacks lime in cement used to cast the blocks - hence, crumbling block.
most waterproofing is really wtr management - we manage leaking wtr instead of stopping it outside,,, in fairness to wtrproofers, most do try to resolve the problem,,, however, customers faint when they hear costs :eek: tin men being what they are, it has become a hit 'em w/big price solution then offer the lo-ball priced band-aid - that's why we have sump pumps :furious: warranty/schmaranty - its still wet & damage is still occurring,,, even most home inspectors are either ignorant of these issues OR stupid for not being more aware :censored:
all having been said, get a wood handled wire brush & have at it - you won't damage good block but may need to patch some w/hydraulic or mortar,,, finally paint 'er w/latex block filler paint :thumbsup:.
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Re: Replace and ReplaceAll -- simple application
Bill Rowe wrote:
> Do you have some definition for "bug" other than performance in
> a manner different than documented?
> That is, failure of any software to do what a user expects is
> certainly not a bug if that is what the software is documented
> to do.
Here's why. By your definition, no program has a bug if the programmer
asserts that the program, by virtue of being written in a high-level
language, is its own readable documentation. Therefore anything that
the program does is documented by its own code and therefore is not a bug.
or in the immortal words of Peewee Herman "I meant to do that".
> The key problem here is a novice user of Mathematica might think
> of using replacement rules as doing mathematics.
Maybe he was confused by the title
"Mathematica -- A System for Doing Mathematics", and thought that
Mathematica was a system for doing mathematics.
That simply
> isn't the case.
Apparently you thought that Mathematica was "A system for doing
rule-based syntactic transformations on FullForm expressions which may
or may not correspond to what is displayed"
And since replacing one thing with another is
> not mathematics, insisting the result makes sense mathematically
> simply isn't a realistic expectation.
TaDa. I couldn't have expressed it better myself. Insisting that the
results of a transformation is mathematically consistent, "isn't a
realistic expectation."
Which, in my view, demonstrates the existence of a bug.
I suppose one could try to determine who is right by a survey, or ask
people in the street what they think.