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On the eve of the 35th annual Bassmaster Classic, a reporter from BASS Times sat down with the man from Pintlala. We wanted to get Ray Scott's take on "how we got from there to here," from a handful of fishermen and newspaper writers standing on the banks of Lake Mead in 1971 to the upcoming CITGO Bassmaster Classic in Pittsburgh, which will be seen by thousands and thousands of fishing fans worldwide on ESPN later this month.
The growth of the Classic has been nothing short of phenomenal. It sprang from the fertile and adventurous mind of Scott, who nurtured it from humble beginnings to the granddaddy of all outdoor sporting events.
Scott watched his brainchild gradually transform recreational fishing into a multibillion-dollar industry. He watched as bass fishing created heroes and high rollers. Through it all, he experienced the highs and lows of this sport, the good times and bad. Yet he remains extremely upbeat about the future of bass fishing.
What follows are Ray Scott's impressions of the Classic from past to present.
The early years
First, we asked Scott how he came up with the name "Classic," which today has become synonymous with the season ending championship of virtually every fishing circuit on the planet, both saltwater and freshwater. It's even been borrowed by hunting organizations.
"The name just came out of my head. I don't remember how I came up with it. The word 'classic' is supposed to indicate a superlative in whatever it is. It's one of the more special occasions of an upper category.
"It came out of my head like a lot of things do. I didn't have any grand scheme to try to calculate a name. And frankly, nobody's ever asked. Like everything else I've done; if it's good, they copy it. If it's not, they let me take the hit and keep moving."
Most BASS members know that the first Classic was held at Lake Mead outside of Las Vegas in 1971. What many might not know is what actually spawned the event.
"The whole idea was born out of the frustrations of not having good coverage from the media," Scott recalled.
"In those days in 1970, Bob Cobb [the original editor of Bassmaster Magazine] and I were driving to a tackle show. It was August, and in the frustration of talking, I said, 'Why don't we have a tournament that takes the top performers of the year and put it on at the end of the season and invite the press and tell them they'll get to ride with the pros?'
"I decided that we would announce it at the end of the season, which would have been about October. We told the guys that next year we'd have this year-end deal. Bob said, 'Where are we going to have it?' I told him we would not tell anybody. We'd say it was a secret. We'd make them guess, and then when the time came, we'd figure out where to take them.
"I thought the sooner we know where it's going to be, the easier it's going to be for the secret to leak out. We wanted it to be a mystery and create a little intrigue about it."
That led to the birth of the early so-called "mystery" Classics in which the pros, wives and media were not told of the Classic site until they were in the air and on their way to the event. Although the weigh-in crowds closely resembled that of a weekly wildcat contest, the first Classic was a success in Scott's eyes.
"History was made that moment," he said.
"My objective was satisfied, because I wanted to let the press know that we were not a bunch of redneck crooks with a pocketful of lead pipes. This was a highly legitimate thing. We had the top media in the group. And it was like a breakthrough. Once we got those heavyweights in there and they saw that the BASS boys were okay, it kicked the door open. The press' support was a great support to the brand."
Tragedy strikes
When we asked Scott to name his most memorable Classic, he offered a surprising and rather somber answer.
"They were all memorable," he replied.
"But one that stands out was the third Classic at Clarks Hill because of a couple of things that happened. I caught a guy cheating. Fish in a basket. I put out a news release telling what he had done. He was guilty as hell, and he knew it. But it was just a fluke that I caught him.
"And then, tragically, we had a guy get killed. One of our sponsors was thrown out of a boat, and the prop killed him. His name was Vernon Fowlkes, and he was from Tulsa. He was going fishing with a guide, and the steering cable broke and he flipped out of [the boat]. Another guide had [country singer] Roy Clark and Carl Lowrance, and they saw the accident. They pulled the body out of the river.
"That is a horrible nightmare memory. It was a tragedy I'll never get over."
The turning point
Scott pointed out that the evolutionary process of the Classic has been so slow that we often don't realize the significance of certain milestones along the way. That's likely the case of the 1981 Classic held in Montgomery, Ala., which was won by 21-year-old Stanley Mitchell. That was the first Classic weigh-in held indoors and an event that kicked the world championship into overdrive.
"The reason I did that was to take out the variable of storms, rain, hurricanes and the like. By then we were getting into television somewhat. That was probably the hallmark. That was probably one of the most important moves we made. In Montgomery, we filled up the coliseum. And it just grew from there.
"Some of my most memorable Classics were those big ones we did back in the days when we were filling up auditoriums with 15,000 or 20,000 people. They were special. We had a center stage kind of thing, and the crowds were roaring. I certainly don't say this with any tone of criticism, but they haven't had that recently in my opinion."
One of the most remarkable advancements in Classic history occurred last year in Charlotte when ESPN Outdoors devoted an unprecedented 11 1/2 hours of coverage to Classic XXXIV.
"We hardly got any television in the early days," Scott noted.
"Maybe some local thing, but nothing like ESPN. I never dreamt it. I get the question almost every day about whether I ever in my wildest dreams thought it would get this big.
"I would love to say this was my master plan. But the truth is, I was so busy living the moment and trying to get to Monday without going broke that I could never have dreamed that big. It was just so damn tough. I had so many angels that helped me along the way.
"It's just like anything else — if you do it well and it's attractive and colorful, people are swept into the curiosity of it and a following develops. I set the foundation for it, and certainly, I thought [the Classic] was a class act in every case."
Memories of the first Classic
Ray Scott had no idea where to hold the first Classic after announcing it to the tournament anglers. Then he received a call from Dave Newton, a Las Vegas tourism official who was familiar with his fledgling tournament circuit. Newton wanted Scott to stage a tournament on Lake Mead. That phone call eventually led to the first Bassmaster Classic.
Scott's strategy for introducing anglers to tournament fishing and recruiting members for his new Bass Anglers Sportsman Society involved traveling the country in a Bluebird Wonderlodge bus and doing seminars with tournament director Harold Sharp and fishermen Roland Martin and John Powell. During a seminar stop in Las Vegas in the spring of 1971, Scott went to great lengths to keep Martin from fishing Lake Mead — to save the sanctity of his "mystery lake" concept for the Classic. "I wanted to have this tournament on a lake that was not familiar to anybody," he said.
One of the 24 anglers invited to participate in that first Classic was totally unimpressed. Florida's Johnny Adams stayed home because he didn't want to waste the vacation time from his job.
In the five years that Scott attempted to stage his mystery Classics, no one ever correctly guessed the tournament waters. "One of my secrets was that I didn't know where it was! I didn't formulize the location until somewhat closer to the event. That created problems, so I couldn't wait too long. But I don't recall that we had anybody outright guess the location."
The weigh-in for the inaugural Classic was held on the roof of a lakeside marina. "You can imagine that the crowds were small because nobody knew we were there until after we got there. There wasn't two school buses worth of people up there, and most of them were family and the people we brought along."
Scott credits the outdoors media with enabling the Classic to evolve into the world-class event that it is today. "I don't think that I ever had more support than what I got from the outdoor writers. They seemed to know that what I was doing was OK. I just don't ever remember getting criticized by them for what we were trying to do."


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I've been here and gone and back. Can't really say when I originally signed on, but I just realized I never intro'd myself. So I figger'd I'd give it a go.
Born and raised in mid-Missouri (no, I'm not going to argue over whether it's "Missouree" or "Missourah", if it's that important to you, God bless ya). Did a couple of stints in south-central Texas (San Antonio/Austin area). Really enjoy both places, but MO is home.
Did a brief stint in the USAF, as a Law Enforcement Specialist. Got out and went a different way with my life. Hadn't really touched a gun in over 20 years when a friend loaned me an M1 Garand for deer hunting (something I'd NEVER done). That was 4 years ago.
Now, my wife and I both have CCW endorsement, are armed nearly all of the time and are teaching our kids the value and joy of responsible gun ownership.


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Established in the 1930s as a trading business, Al-Futtaim is one of the most progressive regional business houses headquartered in Dubai, United Arab Emirates.
Al-Futtaim employs in excess of 44,000 people, operates through more than 200 companies
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Entrepreneurship and rigorous customer focus has enabled Al-Futtaim to grow its
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it operates. Al-Futtaim is committed to offering customers an unrivalled choice
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Structured into four operational divisions; automotive, financial services, real
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businesses flexibility and versatility to maintain a competitive stance. This benefits
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The success of Al-Futtaim is attributed to proactively managing change whilst upholding
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Al-Futtaim is regarded as a pioneer in the region's automotive industry. The company imported the first consignment of Toyota vehicles to the UAE and established Al-Futtaim Motors in 1955.
Al-Futtaim represents 44 automotive brands across 16 countries and encompasses every aspect of the business:
Al-Futtaim Automotive Training Academy
A first-of-its kind training institution that will provide internationally accredited training in a world class facility that is unique in the UAE automotive industry. The Automotive Academy is an important enabler in Al-Futtaim Automotive Division's objective to be the automotive company of choice through providing value based customer experiences enabled by an empowered and engaged workforce.
You will be reporting to the General Manager and your responsibilities in this role are the following but not limited to:
The ideal candidate will have:


text: Official Aerosmith Website [ Aerosmith Announces North American Summer Tour Dates By Jennifer Beaudoin March 26, 2012 Yet another summer tour has been announced, and this time it's Steven Tyler-fronted rock band Aerosmith! The tour kicks off on June 16 in Minneapolis, Minnesota and concludes on August 8 in Tacoma, Washington. Read on to see all the dates in between. Read More Category: Concerts, Music News Tags: aerosmith, global warming north american summer tour, steven tyler Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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US offers Abbas hand of friendship in policy thaw
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The US President, George Bush, has moved swiftly to invite the Palestinian President, Mahmoud Abbas, to the White House following his election on Sunday, in another sign of possible progress in the Middle East impasse.
The open-ended invitation contrasts sharply with the boycott imposed by the US and Israel on Mr Abbas's predecessor, the late Yasser Arafat, who both countries came to reject as a potential partner for peace talks.
"I offer my congratulations to Abu Mazen [Mr Abbas]. I look forward to talking to him at the appropriate time. I look forward to welcoming him here to Washington if he chooses to come here," Mr Bush told a White House press conference.
"This is a man who has been elected by what appears to be a good-sized vote. I'm heartened by the elections."
Mr Bush also telephoned Mr Abbas to congratulate him on his convincing victory - final results show he won 62.3 per cent of the vote. His nearest rival, rights activist Mustafa Barghouti, polled almost 20 per cent.
The US has also signalled that it may free up $US200million ($263million) in direct aid to the Palestinian Authority to help it rebuild capacity for the tasks ahead. In recent years the US - and some other donors - have refused to give money directly to the authority because of its record under Arafat of corruption, non-accountability and, Israel says, support for terrorism.
The election of the moderate Mr Abbas to replace the erratic Arafat, who died on November 11, is being widely portrayed as a useful step towards breaking the Middle East logjam. Signatory of the 1993 Oslo peace agreement and long-term opponent of the use of violence in the Palestinian struggle, Mr Abbas based his campaign on the need to re-engage Israel in peace talks.
Following a meeting with international poll observers on Monday, Mr Abbas declared that "we extend our hands to our neighbours".
"We are ready for peace; peace based on justice. We hope that their response will be positive."
His election has also been well received, although quietly, in Israel. The Prime Minister, Ariel Sharon, said that he welcomed Mr Abbas's victory but that Israel would now be watching to see whether he could restrain militants who continue armed attacks against the Jewish state.
"He will be tested based on the way in which he fights terrorism and dismantles their infrastructure," Mr Sharon said.
The election of Mr Abbas coincides with a major domestic victory for Mr Sharon, who on Monday formed a new ruling coalition designed to push through his planned withdrawal of Israeli troops and settlers from the Gaza Strip later this year.
On Monday the Knesset, Israel's parliament, narrowly voted to endorse a new coalition of Mr Sharon's rightist Likud party, the centrist Labour Party and United Torah Judah, a small party representing ultra-Orthodox Jews, by 58 votes to 56.
By bringing in former prime minister Shimon Peres and his Labour Party, traditionally the Likud's arch-rivals, Mr Sharon seeks to guarantee his administration enough votes in the Knesset to be able to ignore on-going rebellions by Likud factions still professing the party's traditional opposition to withdrawal from any of the biblical land of Israel.


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|Home > Features > Issues > Science > Article
Children with reading problems may one day be able to take a pill that helps them to read better, according to researchers chasing the elusive "reading" gene.
Cathy Barr, of the Toronto Western Hospital in Canada, said one of the most likely culprits was a memory suppressor gene known as PP1, which helped the brain regulate the information it retained.
Dr Barr told the International Genetics Conference in Melbourne studies on twins had shown reading difficulties were highly heritable.
"Up to 40 to 60 per cent can be accounted for by genetics," she said.
Family studies in English-speaking countries, as well as in Tanzania and Italy, had pinpointed specific areas on chromosome 6 where genes involved in reading disorders seemed to cluster.
No specific gene had yet been fingered, she said, but researchers were confident they were closing in.
"Now the role is to find those genes," Dr Barr said.
"The regions are quite large and what our group... is trying to do is narrow the regions and look at genes in the regions that in animals have been shown to relate to reading disability."
Dr Barr said PP1 might be linked to the ability to keep verbal information in the short-term memory - something people with reading disabilities had trouble doing. Studies showed that mice could learn in less time if PP1 was inhibited.
Other possible genes were involved in brain development and the maturation of neurons.
Once a gene or genes were located, it could be possible to develop a medication to treat reading disorders, given the success of the attention deficit disorder drug ritalin.
"There's a relationship between ADHD and reading disability, especially inattention symptoms, so it may that medication is easily developed," she said.
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Prognostic value of telomere attrition in patients with aplastic anemia
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DOI: 10.1007/s12185-013-1332-x
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- Scheinberg, P. Int J Hematol (2013) 97: 553. doi:10.1007/s12185-013-1332-x
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The decision to pursue hematopoietic stem cell transplantation or immunosuppression as first therapy in severe aplastic anemia is currently based on age and availability of a histocompatible donor. The ability to predict hematologic response, relapse and clonal evolution could improve treatment allocation. In the past 15 years, telomeres have been implicated in clinical diseases such as aplastic anemia, pulmonary fibrosis, cirrhosis and cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex (TERC, TERT) is evolving in aplastic anemia. A large retrospective analysis suggests that baseline TL associate with late events of hematologic relapse and clonal evolution in aplastic anemia patients treated initially with anti-thymocyte globulin-based therapy. Further laboratory experiments propose possible mechanistic insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or mutation in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal evolution rates in humans. This review will summarize studies in marrow failure that explore the association between telomeres and aplastic anemia outcomes.
KeywordsAplastic anemia Telomeres Relapse Clonal evolution Pancytopenia Immunosuppressive therapy
Up to 40 years ago, severe aplastic anemia (SAA) was associated with a high fatality rate 1–2 years after the diagnosis. However, the majority of patients nowadays are expected to be alive long-term following the diagnosis of SAA. The treatment modalities that contributed to this success are hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST). Although the toxicities vary between these two approaches, long-term outcome with either therapy is comparable [1]. In general, HSCT from a matched related sibling donor is applied to children and adults up to the age of 40 as first therapy, while IST is often employed in older patients (over 40) or when a sibling donor is not available [1, 2]. Thus, the decision to pursue either therapy relies nowadays on age and matched related donor availability. Comorbidities can play a role in the decision-making, however in general younger patients with SAA usually do not have other significant underlying illnesses that preclude a matched related HSCT.
HSCT is curative in the majority of patients, and IST is often associated with hematologic response rates that have ranged from 60 to 75 % across many large studies in the United States, Europe, and Japan [3]. However, graft rejection, infections, and more importantly, graft-versus-host disease (GVHD) limit the success of HSCT, while unresponsiveness, relapse and clonal evolution to myelodysplasia (MDS) limit the success of IST. Unfortunately, there are no practical robust marker(s) that can predict these important outcomes following HSCT or IST which could better risk-stratify patients allowing for a more rational treatment allocation. There have been many reports towards this goal; however, none has been widely adopted yet into clinical practice. In this review, some of these efforts will be summarized which could allow for better decision-making algorithms in the future.
Important outcomes following IST
The important outcomes to be considered following IST are hematologic response, relapse and clonal evolution to MDS and survival. In general, response can be anticipated in 2/3 of cases, relapse in about 1/3 of responders and evolution in 10–15 % long-term [4, 5]. The standard IST regimen in SAA is with the combination of horse anti-thymocyte globulin (h-ATG) and cyclosporine (CsA). This regimen has been shown superior as first therapy to alternative regimens such as rabbit ATG or alemtuzumab in randomized studies [6, 7]. The most important predictor for long-term survival is hematologic response at 3–6 months following h-ATG/CsA [4]. Relapses, in general, are not usually associated with a dire outcome since most do respond to more immunosuppression with CsA or another course of IST [4, 8, 9]. Clonal evolution, however, remains a significant problem especially with the appearance of a monosomy 7 karyotype or evidence of high-grade dysplastic findings with increase in blasts [1, 10].
Can hematologic response be predicted?
There have been several attempts to predict hematologic response in SAA following IST. Some research laboratory findings that reflect the pathophysiology of SAA, such as the increased ratio of activated T cells, increased interferon-γ expression in bone marrow and peripheral T cells, increased expression of heat shock protein, and the presence of small numbers of aneuploid bone marrow cells have been proposed as useful in prognosis; however, these methods, which are not currently either generally available or applied, require validation [11, 12, 13, 14]. A more simplified approach has been to associate the presence of a paroxysmal nocturnal hemoglobinuria (PNH) clone with response. The presence of a PNH clone at baseline has been suggested as a marker of a favorable response to IST in adults by using a more sensitive flow cytometric assays that improved detection of small clones compared to the more traditional Ham's test [15]. A correlation of a PNH clone with response, however, has not been confirmed in other studies [16, 17].
Quantitative assessment of reticulocyte count has been proposed as marker for response, maybe serving as an indirect measurement of marrow reserve [16, 18, 19]. In a large retrospective study, those with a higher baseline reticulocyte count had a higher probability of response and survival compared to those with a lower reticulocyte at baseline. This parameter has been confirmed in some reports but not in others [20, 21]. Of interest is that robust reticulocyte recovery at 3 months following IST has been associated with better survival outcomes and baseline reticulocyte count associated with response in a study of a thrombomimetic, eltrombopag, in refractory SAA [4, 22]. The absolute neutrophil count appears to be associated with short-term mortality in many reports, but this observation was not confirmed in a German experience in children [23, 24].
Age has been a more consistent defining predicting parameter across many studies. In general, children do have a higher response rate compared to older patients following IST [16, 25, 26, 27, 28]. The response rate in children is usually reported in the 70–80 % range with excellent survival among responders, compared to a 60–70 % response rate in younger adults and a 50–60 % rate in those over the age of 40–50 years of age. Although there has not been a randomized study comparing the more intense IST with h-ATG/CsA to HSCT, the latter is the preferred modality in children and young adults with a histocompatible donor, while the former is an excellent alternative among those without a related donor.
Can hematologic relapse and clonal evolution be predicted?
These two late events can be associated with morbidity and mortality in patients in follow-up. The mechanism involved in these complications are poorly understood however continuing subclinical immune destruction of stem cells or hematopoietic exhaustion has been proposed for relapse, and selection of pre-malignant clones resistant to apoptosis, proliferative advantage, and genomic instability proposed for evolution. In practice, it is difficult to assess these parameters quantitatively or qualitatively.
Defect in telomere repair mechanisms has been implicated in inherited forms of marrow failure such as dyskeratosis congenita, which are generally diagnosed at a young age after a presentation of aplastic anemia associated with physical abnormalities early in life [29]. Telomeres represent the ends of chromosomes which progressively shorten with each cellular division resulting in its shortening. A critical short telomere length (TL) results in a cessation of replication and cell death. To counter this erosion, the telomerase complex adds short nucleotide repeats (TTAGGG) to the ends of chromosomes (telomeres) which each division slowing the attrition rate. This complex is composed of an RNA template that is encoded by TERC and a catalytic subunit encoded by TERT. In general, expression of telomerase is low in most somatic cells however, in hematopoietic stem cells and lymphocytes which have a high proliferative capacity expression is high. Mutations in TERC and TERT have been identified in 5–10 % of acquired SAA cases who present later in life without physical abnormalities [30].
Early reports suggested that telomeres were short in up to one-third of patients with SAA [31, 32]. Initially, this occurrence was presumed to be secondary to hematopoietic "stress". However, the discovery of loss-of-function mutations in genes of the telomerase complex (TERC, TERT) established a genetic etiology for telomere attrition in some patients with marrow failure who did not have the stigmata associated with an inherited bone marrow failure syndrome [33, 34]. In the past 15 years, the relationship between TL, genetic defects in the telomerase complex and marrow failure has been an area of great interest. In a large retrospective analysis at the National Institutes of Health (NIH), 183 patients with SAA treated on sequential prospective ATG-based immunosuppression protocols had their outcomes correlated with age-adjusted TL of peripheral blood leukocytes at baseline measured prior to study entry [35]. The main outcomes included in the analysis were hematologic response at 6 months, relapse, clonal evolution, and survival. For this analysis, the TL was divided into 4 quartiles with the shortest lengths represented in the first quartile, while the longer lengths represented in the fourth quartile. There was no relationship observed in this study between baseline TL and hematologic response at 6 months. The response rate for patients with TL in the first quartile was 57 % [95 % confidence interval (CI) 42–71], second quartile 54 % (95 % CI 39–69), third 60 % (95 % CI 45–75), and fourth quartile 57 % (95 % CI 42–71).
However, a relationship between TL with relapse and clonal evolution was observed [35]. When measured as a continuous variable, TL inversely correlated with the probability of relapse [hazard ratio (HR) 0.16 (95 % CI 0.03–0.69); p = 0.01]. The risk for relapse progressively decreased from quartiles 1 (shortest) to 4 (longest). For clonal evolution, a higher rate of cytogenetic abnormalities was observed in those in quartile 1 (25 %, 95 % CI 9–38) compared to quartiles 2–4 (8 %, 95 % CI 3–13; p = 0.009). More importantly, higher risk cytogenetic defects such as monosomy 7 and complex cytogenetics were noted in quartile 1 (19 %, 95 % CI 4–32) compared to those in quartiles 2–4 (5 %, 95 % CI, 0.5–8, p = 0.002). Overall survival also differed at 6 years between those with TL in quartile 1 (66 %, 95 % CI 53–83) and quartiles 2–4 (84 %, 95 % CI 77–91; p = 0.008). It is important to note that a genetic defect in TERC or TERT was identified in only 1 patient in this cohort. Thus, this study described a relationship between TL within the normal range and late events in SAA following ATG-based immunosuppression.
It is unlikely that TL is a simple biomarker for late events in SAA, but that it is also involved in the destabilization of the genome and participates in the etiopathogenesis of clonal evolution. A short TL has been widely associated with the development of human cancer in population-based studies and in pre-malignant inflammatory conditions such as Barrett's esophagus and inflammatory bowel disease [30, 36, 37, 38, 39, 40]. In a follow-up study by Calado et al. [41], bone marrow cells from patients in the NIH cohort were studied for the presence of monosomy 7 by fluorescent in vitro hybridization (FISH) at diagnosis. A strong inverse correlation was observed between average leukocyte TL and the percentage of monosomy 7 cells by FISH in the marrow (r = −0.503, p = 0.001). An increased frequency of telomere signal free ends (a marker for very short TL and genomic instability) was also noted in cultured bone marrow cells of patients with a lower average TL (lower quartiles) compared to those in the upper quartiles or healthy subjects. In addition, a significant proportion of numeric aberrations and structural chromosomal abnormalities were observed in cultured bone marrow cells from patients with the shorter TL compared with patients with longer telomeres or to healthy controls [41]. Finally, cultured telomerase-mutant marrow cells from individuals identified in family studies of patients with aplastic anemia and telomerase mutations developed an increase proportion of aneuploid cells when compared to bone marrow cells of healthy individuals under same culture conditions. These observations support the notion that short and dysfunctional telomeres restrict the proliferation of normal hematopoietic stem cells and lead to the selection of genomic unstable cells.
Although the average TL is often used in correlative studies, it is the shortest telomeres that contribute to chromosomal instability rather than the average TL [42]. A more sensitive assay of single telomere length assay (STELA) using a single PCR reaction to amplify chromosome-specific telomeres allows for the identification of critically short TL regardless of the average TL by qPCR [43]. In a small study presented in abstract form recently, very short TL by STELA was present in a higher proportion of SAA patients who progressed to MDS when compared with complete responders to immunosuppression [44]. Ongoing studies to better define the heterogeneity of TL by STELA and their clinical consequence could identify very short telomeres in a subpopulation of cells that pose a greater risk for clonal evolution in some aplastic anemia patients.
Can telomere attrition rate be modulated in vivo?
The historically low rate of clonal evolution in AA patients who recovered with androgens suggests therapeutic opportunity with these agents to decrease evolution rates long-term [45]. The possible role of a critical short TL and clonal evolution in AA raises the possibility that modulation of telomere attrition may reduce clonal events in humans. Exposure in vitro of human peripheral blood leukocytes and bone marrow cells to androgens has been shown to increase telomerase activity along with increased expression of TERT mRNA [46]. This observation was expanded in vivo where mice under certain hematopoietic stress had a reduced attrition rate when treated with testosterone compared to mice who received a corn oil control [47]. A recent case report in an aplastic anemia patient suggests that continued androgen use might be associated with hematologic improvements along with TL elongation of peripheral blood leukocytes [48]. Thus, the effect of androgen therapy on increasing telomerase activity might contribute to slowing telomere attrition, assisting in cell regeneration and ultimately prevent genomic destabilization. In order to address this modulatory possibility in humans, an ongoing clinical trial (clinicaltrials.gov NCT01441037) at the NIH is currently investigating the activity of danazol in patients with a telomere disorder associated with hematologic or pulmonary disease. The objective of this study is to determine if androgen therapy can reduce the telomere attrition rate in this patient population with a 2-year course of danazol.
In conclusion, biomarkers that correlate with hematologic response, relapse and clonal evolution would greatly enhance risk-stratification and allow for better treatment allocation in SAA. For example, younger patients with a low probability of response and high probability of late events might benefit more from an unrelated donor HSCT as first therapy, while older patients with a similar risk profile benefit more from a matched sibling donor HSCT. The association of TL and late events (relapse, clonal evolution) requires validation before entering decision-making algorithms in SAA. The possible role of short telomeres contributing to genomic instability and evolution to MDS opens the possibility of investigating agents that could modulate the attrition rate and hopefully reduce the rate of this complication. The clinical relevance of genetic defects in telomerase genes in patients who otherwise present with 'acquired' SAA is still evolving. Some patients with known mutations in TERT or TERC can respond to IST similarly as in non-mutants [49]. If a genetic defect is sufficient to define the pathogenesis in some cases of apparent acquired AA or it is a contributor to other pathophysiologic mechanisms of marrow destruction such as an aberrant immune system remains to be defined.


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"Who knew that being away would make us so homesick?"
Those are the words spoken by Jeff to Danny in the middle of Lucy Thurber's bleak and brutal play, Killers and Other Family, at the Axis Theater. The "home" of which Jeff speaks is the one up in the country, which they recently fled due to Danny's murder of a local girl. Seeking money for a getaway to Mexico, they've landed at the New York apartment of Jeff's sister, Lizzie. She's less than thrilled to see them, partly because she's about to finish her doctoral thesis, and partly because she and Danny have, well, a past--- the kind that involves a broken home and a serious dose of statutory rape. It gets even messier when Lizzie's girlfriend Claire comes home early for lunch, only to be entrapped in this cauldron of manipulation, score-settling, and eventually some awful violence.
But back to the "homesick" part. Jeff's unwitting insight--- that the more we escape our past, the more we're strangely drawn back to it--- would seem to be the key to understanding The Hill Town Plays, the unhappy series of five by Thurber currently running in theaters around the West Village and presented by the Rattlestick Playwright's Theater. Thurber's lead characters, all of them female, are always in the process of escaping (or have already escaped) their desperate small-town circumstances. But the past has a way of catching up, and whatever their fancy adulthood laurels, these women find themselves haunted by a family background that failed them over and over again.
Except for Killers, which unfolds in that fairly well-appointed Manhattan apartment, all of the plays take place in the Hill Towns of Pioneer Valley, a lush and largely rural section of Western Massachusetts. The region is known for its unspoiled views and draws plenty of upscale tourism, but the folks who inhabit Thurberland are not the type to spend the day antiquing. Jobs are of the grungy, physical sort, and most free time is spent in the company of illicit substances.
Let's start with Rachel, the volatile preteen at the heart of Scarcity, at the Cherry Lane Studio. She's the youngest of Thurber's heroines, and she has the burden of navigating an abusive alcoholic father, an enabling mother, and a gifted older brother, Billy, who's bent on escape. Billy has come under the protective wing of his teacher Ellen, whose motives are not strictly professional. When Billy lands the opportunity to attend a prestigious boarding school, Rachel goes positively nuts, fearing that he'll leave her behind and never come back. "I don't know how much more I can take," she moans.
We next meet this young woman in Ashville, at the Cherry Lane Mainstage, though she's now called Celia. (Thurber has explained that while all of the plays feature "the same girl," she decided to vary the names and circumstances a bit for each.) Celia is sixteen, living with her broken mother and boyfriend Jake, a local burnout who thinks of himself as Celia's sole protector (reminding her as often as he can) and who soon proposes marriage. Celia, though, is rather entranced by Amanda, the girl down the block who can recite Lewis Carroll's "Jabberwocky" from memory, along with a charming interpretive dance. Celia's sexual awakening has begun, and by the end of "Ashville," we get the sense that she's headed for better things.
So she is. In Where We're Born, at the Rattlestick, Lilly (as she's now called) returns home from a semester at college in Northampton, where she made the honor roll and may or may not be dating a "rich guy with a BMW." At home, she's staying with her cousin Tony and his girlfriend Franky, ending up in a complicated romantic situation involving both of them. In the meantime, they share drinks with hometown friends like Vin, who goes on a memorable rant about "red-blooded Americans" being pushed aside by brown-skinned folk. "Soon they'll be coming up here and I got my gun," he says, in a reminder of the attitudes that Lilly has been trying to escape.
After that is Killers, mentioned above, followed at last by Stay, at the New Ohio, which brings us back to the plights of Rachel and Billy, names and all. Twenty years later, she's a successful writer and visiting professor at a small liberal arts college, while he recently lost his job at a law firm for hitting the boss's daughter after an illicit affair. (The daughter was "this cute little rich button and she'd get so hot when I'd tell her stories about Mom, Dad, and my poverty roots," he observes.) A student named Julia comes into Rachel's office, confessing that she's "obsessed" with her, and soon they're enmeshed in a passionate fling, which rather upsets Julia's boyfriend, Tommy. Unable to trust much of anything by now, Rachel starts manically wondering whether anyone will stay around in her life--- including her imaginary friend (or muse) known only as Floating Girl.
Taken as a whole, Thurber's portrait is both incisive and unyielding in its detailing of life on the margins. Scarcity and Where We're Born are, among the five, the most fully satisfying nights at the theater. Killers was simply too implausible and casually violent for my taste, and it felt like an unwelcome disruption from the kitchen-sink realism of the others. Stay also experiments with its theatricality, faring better, but the final third of the play--- an extended lesbian fantasia that ends in song--- doesn't make much sense. (I also questioned the need for the many monologues about the horror of Billy and Rachel's childhood, having already seen an entire play about it.)
Ashville, receiving its world premiere, demonstrates both Thurber's talent and some of her less appealing habits as a writer. As these characters ramble through life, so does their dialogue often lack any shape or texture of its own. Scenes end abruptly, people shift emotions instantly, and the plot unfolds with laborious slowness. This can be disorienting, especially because the lives on display seem so unremittingly bleak. The audience is sometimes forced to share in the misery, without a firm moral center to grasp onto, or even a dash of real humor to mitigate the suffering. It's like watching raw footage of a long, sad, subtle decline, without the honing work of an editor and without a thoughtful, specific point of view. Perhaps, with time and through other productions, Ashville will come into its own.
There are moments, and performances, that will linger. The directing and acting across all five plays is uniformly excellent, but there are standouts. These include: Mia Vallet as the troubled, beautiful adolescent Celia; Samantha Soule as Elizabeth, and especially Aya Cash as the put-upon girlfriend Claire; the entire ensemble of Where We're Born, which blends together harmoniously in their scenes together; Didi O'Connell as the acidic mother in Scarcity; and Hani Furstenberg and McCaleb Burnett as the grown-up Rachel and Billy in Stay. The set designs of both Stay (by Rachel Hauck) and Ashville (by John McDermott) were especially inventive.
And: try not to miss Scarcity. Dark it may be, but the tight script has been thrillingly directed by Daniel Talbott and is zestfully performed by the company. You certainly wouldn't want to live in this run-down apartment, with the drinking, the screaming, the slamming doors, the police visits, the adultery, and the constant threat of sexual abuse. But it's the most vivid and true offering of The Hill Town Plays, and it suggests that physical escape is certainly possible, even if the wounds never quite heal. As Rachel's Dad says to her, in an unusually friendly though impossible-to-follow bit of advice: "The trick is kid, you've got to learn to ignore us. If you can, just learn to do that; you'll be O.K."


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Staff Sgt. Thomas Hosfelt, is presented the Purple Heart by Brig. Gen. Max Haston, Assistant Adjutant General of the Tennessee Army National Guard, at Forward Operating Base Mosul, Iraq.
SubmittedStaff Sgt. Thomas Hosfelt, a squad leader in the Tennessee National Guard's 269th Military Police Company from Murfreesboro, was awarded the Purple Heart during a ceremony at Forward Operating Base Mosul on May 28 for injuries he sustained while serving in Iraq.
On Feb. 24 of this year, Hosfelt and his squad were conducting an inspection visit at an Iraqi Police Station in Mosul when two men wearing Iraqi police uniforms opened fire on the team with AK 47 assault rifles. While shot in the right side of his face and in his upper left shoulder, Hosfelt returned fire as the assailants fled the scene. He then administered first aid to the wounded and coordinated with other units to secure the area and transport his soldiers to the hospital.
1st Lt. William Eric Emmert, from Fayetteville, was killed during the attack and three other Tennessee Guardsmen, including Hosfelt, were wounded. Emmert's parents reside in Lebanon. Hosfelt's injuries allowed him to remain in Iraq and return to duty. The other two wounded Guardsmen are currently receiving medical care in the United States and received their Purple Hearts at earlier ceremonies.
"I'm proud of the job our soldiers are doing in Iraq, and I'm especially proud of this young Tennessean," said Brig. Gen. Max Haston, Assistant Adjutant General of the Tennessee Army National Guard. "Without hesitation, Hosfelt placed himself in harm's way to help his fellow soldiers." Haston was in Mosul last month visiting Tennessee Guardsmen and personally presented the Murfreesboro soldier with the award.
The Purple Heart is one of the most widely recognized and respected medals. It was established by General George Washington at Newburgh, New York, during the Revolutionary War on Aug. 7, 1782. Originally created as a Badge of Military Merit, the Purple Heart is awarded in the name of the President of the United States to any member of the U.S. Armed Forces who has been wounded or killed during combat with a declared enemy.
"I was just doing my job," Hosfelt said. "I volunteered to deploy and I'm proud of the job the 269th Military Police Company is doing in Iraq. But the real heroes of that day were my squad."
The 269th Military Police Company is scheduled to return to Tennessee in November.


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does anyone have a downloadable or printer friendly outline of boba or jango uncolored just the outline. either one i dont care i just need for a mock up for paint.
thanks guys!
Printable View
does anyone have a downloadable or printer friendly outline of boba or jango uncolored just the outline. either one i dont care i just need for a mock up for paint.
thanks guys!
Check out the Mandomaker at http://www.mercs.firespray.net
i know of that one i need to print out just a plain no color boba so we can test paint it... with real paint.
I would recommend that you not redirect to another website since the templates are hosted here on The Dented Helmet. We do like to share, but not to have people drawn away when we have had such detailed templates first.
You can find the wizardofflight templates here:
If you want to start with just the helmet, you can check my recent drawing here:
kids chill. lol. its cool i asked for help i got it.
thanks to those that helped! i got some coloring to do.
-El Fuzzy
this is from the WOF templates...hope no'one minds me putting it up...if so i'll take it off
Just curious
Also I think he was looking for a drawing of boba or jango to test color concepts not to make armor.(Like a coloring book page,Pencil drawing, open vector)
well i figured that might be of some use...sorry for wasting ur time
I was curious about the "don't post links to other forums", if this is a real rule, or a rule that was thrown out there in the heat of the moment. Maybe a mod can comment on this?
Sorry if you felt i was posting on your reply, that was not my intentions
Sorry again
You may post links to other web sites as long as they do not violate the following from the COC.
This website contains links to other sites. Please be aware that we [The Dented Helmet] are not responsible for the privacy practices of such other sites. We encourage our users to be aware when they leave our website and to read the privacy statements of each and every website that collects personally identifiable information. This privacy statement applies solely to information collected by this website.
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Thank You very much for the confirmation
again thanks guys i got what i needed and the armor is currently in paint. gonna be a while since it dips to 15 below at night some times out here screwing up teh dry time.
-El Fuzzy


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TAG warrants this product to be free of defects in material and workmanship, when used by the purchaser under normal conditions. The warranties herein specified shall not apply if the failure of any component of this product to satisfy such warranty is due to accident, neglect, misuse, improper transportation arranged by the purchaser or its agent, or causes other than ordinary use including operation contrary to TAG's operating instructions.
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text: Italianità at the former water works: the menu is changing monthly, «vino» already on the table and the «caffé» tastes really Italian. Industrial design meets wooden cosiness and beautiful lighting. Aperitif and cocktails at the bar, sophisticated lounging on generous divans, summer evenings at the beautiful garden: Classy pleasure right beside Kuppel & Garage.


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text here. Few sentances.PROS
List, of, prosCONS
List, of cons
The Pitch: "Detoxify your body while you sleep"Pros
Kinoki Foot Pads are self-adhesive strips that are supposed to draw harmful toxins like heavy metals and "metabolic wastes" from the body through the feet, turning from white to dark in the process. The infomercial says that the darker the pad, the more toxins are cleansed from your system. However, in professional and user reviews, most people say the pads don't do anything at all. Most customers who try the Kinoki Foot Pads claim to feel no different after using them, and they complain of how awful the pads smell when removed.
In more scientific testing, several used pads were lab-tested for various toxins and metals, but none were found in the pads. Doctors agree that if users are experiencing an improvement in their health and level of energy, it is probably due to the placebo effect.
A small percentage of users like the effects of the Kinoki Foot Pads, saying they notice certain health improvements after using them. While most positive reviewers agree that it's probably the placebo effect causing these improvements, they don't see any harm in continuing to use the pads.
An ABC News "20/20" report tries the Kinoki Foot Pads on a group of volunteers and consults a specialist; all agree that the pads don't really do anything, though they probably aren't harmful. Reporters for MSNBC and the Los Angeles Times also put the pads to the test, coming away with the same conclusion, and even finding that any kind of moisture (including sweat and plain water) can discolor the pads. Customer reviews on InfomercialRatings.com are split, with some calling the Kinoki foot pads a scam and others saying they notice certain improvements. Most of the customers on Amazon.com are displeased with the Kinoki pads, but a few think they helped improve their swollen or sensitive feet.
1. 20/20
Ridding Yourself of Toxins, or Money?, John Stossel, April 11, 2008
As part of an ABC News "20/20" program, John Stossel puts the Kinoki foot pads to the test with a group of volunteers. They all report that they feel no healthier or more energized after using the pads. The Kinoki Foot Pads looked filthy when removed, but after running a test on the used pads, the lab results found no toxins or heavy metals in the pads. The testers all agree that the pads do not work; two of them describe the pads as a "scam." Stossel also interviews Dr. George Friedman-Jimenez, a specialist in environmental medicine, who agrees that the Kinoki Foot Pads have no health benefits. If users claim to feel better, Friedman-Jimenez says, "The placebo effect contributes to the improvement in the symptoms."
Kinoki Foot Pads: Sucking Away Toxins Or Just Your Money?, Paige West, June 19, 2008
Paige West tries the Kinoki Foot Pads for two weeks and finds that despite a boost of energy after the first night, they don't work. Each morning the pads are black and smell awful -- "a vile combination of sweat and the acrid smoke of a campfire," she says. Contrary to what the commercial says, they do not get increasingly clear as she continues to use them. West consults with Dr. Devra Davis, an expert on toxins, who speculates that the Kinoki foot pads just contain green tea and vinegar. Both West and Davis agree that the Kinoki foot pads probably aren't harmful, but they don't have any health benefits, either.
Kinoki Foot Pads' Detox Claims Don't Stand up to Science, Chris Woolston, Sept. 22, 2008
Los Angeles Times reporter Chris Woolston contacts several doctors and health experts for their opinions on whether the Kinoki foot pads could actually improve a person's health and energy. The unanimous conclusion is that they cannot. Woolston tries the Kinoki pads out himself, and while they come away dirty each morning, he doesn't feel any different. He even tries dripping some saline solution on a clean pad, which turns the pad dark and grimy just as it is after being used on a person's foot, leading Woolston to conclude that any kind of moisture can discolor the pads.
Kinoki Foot Pads Reviews and Ratings, Contributors to InformercialRatings.com
More than 40 customers review the Kinoki foot pads on InfomercialRatings.com, and the reviews are split pretty evenly. Those who give negative reviews agree with health experts who say the pads simply don't do anything to improve their health or energy. They also echo the common complaint that the pads smell terrible after being used. Those who like the Kinoki foot pads say they work, claiming improvements such as better digestion, deeper sleep and increased energy. Most positive reviewers admit that they don't know if the pads really do remove toxins from the body, or if their improved health is due to the placebo effect, but they like how they feel while using the Kinoki foot pads, so they will continue to do so.
5. Amazon.com
Kinoki Cleansing Detox Foot Pads (14 Ct), Contributors to Amazon.com
A handful of customers review the Kinoki foot pads on Amazon.com, and most agree that the pads don't do anything as they don't feel any different after using them. A couple of reviewers like the pads because they help to alleviate their foot problems, like swollen and sensitive feet, and find using the pads is easier than soaking their feet in water.
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text:
|Jara, Alejandra
|Goldberg, Sabine
|Mora, M
Submitted to: Journal of Colloid and Interface Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/19/2005
Publication Date: 12/1/2005
Citation: Jara, A.A., Goldberg, S.R., Mora, M.L. 2005. Studies of the surface charge of amorphous aluminosilicates using surface complexation models. Journal of Colloid and Interface Science. 292:160-170. Interpretive Summary: Aluminosilicate minerals are important constituents of volcanic soils. We investigated the surface charge properties of two types of synthetic aluminosilicate minerals. We were able to describe the surface charge behavior of both minerals using two chemical surface complexation models. Our results will improve predictions of surface charge and adsorption behavior of these minerals. This improved understanding will allow better management of these agriculturally important soils.
Technical Abstract: Synthetic noncrystaline aluminosilicates with variable charge, similar to allophanes present naturally in volcanic soils, were studied. The surface charge behavior was determined by zero point charge (ZPC) measured by electrophoretic mobility (isoelectric points, IEP) and determined by potentiometric titration (point of zero salt effect, PZSE). The ZPC calculated by Parks model (ZPCc), compared with IEP values, showed that the aluminosilicate (AlSi) surface was slightly enriched by AlOH (34% Al2O3 and 66% SiO2) compared with the bulk composition (29% Al2O3 and 71% SiO2). For aluminosilicate coated with iron oxide (AlSiFe) the ZPCc (4.4) was lower than the IEP (8.46), showing that the surface composition is formed mainly from iron oxide. The PZSE values for AlSi and AlSiFe were 6.2 and 4.8, respectively. The differences between the IEP and PZSE are attributed to the formation of Si-O-Fe or Si-O-Al bonds; therefore, the reactivity of Fe and Al atoms was modified on the surface. Two mechanistic models, the Constant Capacitance Model (CCM) and the Triple Layer Model (TLM), using the program FITEQL 3.2, were able to describe the surface behavior of both synthetic aluminosilicates. The acidity constants determined using both models for the aluminosilicates showed differences with respect to pure oxide, mainly attributed to the presence of SiOH sites on the internal surfaces. The ionic strength showed a good relation with the parameters obtained using the CCM (pKa1(int), pKa2(int) and capacitance values) and the TLM (Ka1nt, pKa2(int), pKCl-(int), pKK+(int), and inner capacitance) for both aluminosilicates. However, the TLM was able to describe the acidity and complexation constants better since it considered the formation of the outer sphere complex between the background electrolyte and the surface. Then the TLM makes it possible to describe real systems.


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Best Of :: Food & Drink
Fernando Lopez is an artist. He writes screenplays and sculpts, and he believes someday he'll make it as a filmmaker. But seven years ago his wife Belkis talked him into opening a juice shop, and that has provided a living for the couple and their three young children. Fernando's artistic sensibilities and Belkis's culinary talents have also made their little restaurant a popular stop for the work-week crowd that appreciates lunchtime specials such as turkey peccadillo and veggie lasagna. The storefront café gives off a time-capsuled Seventies vibe, thanks in part to Fernando's colorful artwork on the walls and the aroma of steaming vegetables and tamari. But also featured on the menu are luscious smoothies and vegetable-juice combos to cure every ill, from arthritis and acne to indigestion and impotence. And if you don't know what ails you or just what you need, Fernando is not shy about making an instant diagnosis. Open for breakfast and lunch, from 9:00 a.m. to 5:00 p.m. Monday through Friday.
C'mon, an overpriced sushi joint? We only have about a hundred of those, so why reward a new one? Well, friends, try out Nobuyuki Matsuhisa's dishes and then come back and tell us it wasn't worth every penny. So what if some whine about the décor. People! Style over substance has been Miami's cement shoes for too long. And so what if the super-fresh sashimi melted in your mouth so quickly and deliciously you almost forgot you just ate it. And who cares if chopsticks were used as weapons for the very last crumbs from the black codfish with miso. It doesn't matter. What does matter is this: Miami finally has a Matsuhisa masterhouse to return to over and over again for more of the same. For the first time in a while, a restaurant has opened that can truly contend with the best of the best.
A delicate rose fashioned from slender blush-pink slices of tuna. Carefully carved thin strips of cucumber wrapped around crab stick, avocado, masago, and shrimp. Wooden boats bursting with artfully arranged squares of fish. How fresh is it? Take a glance behind the sushi bar. If the huge white tuna slumped across the sink, ready for carving, is any hint, very.
Chocolate is not a bad or dangerous thing. Chocolate is good medicine for the brain, the blood, the sweet tooth. And the Sweet Tooth's chocolate is very good, made on the premises. From chocolate hearts and cherries to truffles and luscious creams, feast your eyes (did we mention chocolate improves night vision?) on the velvety array of goodies at this well-equipped chocolate clinic. The selection is so stunning, especially on holidays, you may be temporarily paralyzed. The Sweet Tooth people know how you feel and have thoughtfully prepared all kinds of beautiful and therapeutic gift baskets and boxes.
No, it's not really about the drinks. You've had those before. And it's not really about the décor, which is clean and fine but not spectacular. It's also not about the specials, because there aren't really official hours for happiness here. It's about the only reason people seek out happy hours to begin with: the scene. What? On Miracle Mile in the stuffy Gables, you might sneer? Yup. There's a new dawn in that part of town and it's raising a toast at the new Houston's after work. Good mix of cocktails, ages, ethnicities, sexes, economic positions. The men and women behind the bar are friendly, as are the people sitting next to you. Starting late in the afternoon on Friday often you won't find a stool or even standing room, so the party spills out into the street. If you need further proof this isn't the Gables of old, consider: Once you've downed your after-work libations, you can move on to other attractions. Huh? Life after 8:00 p.m. in the City Beautiful? Yes, truly a new dawn.
This is truly the hole-in-the-wall that has it all. Almost indistinguishable from the other storefronts along this part of North Miami Avenue, Clive's makes its mark at the cozy counter set up with great Jamaican favorites like curry goat, oxtail, and cowfoot. With ample food packed on a five-dollar special, this is a can't-miss deal every afternoon. The chicken is cooked to diner perfection and the curry is a smooth blend that avoids the fire-alarm spices of other native cuisines. The mood is laid-back, with a pleasant Mrs. P taking good care of the customers and a small radio pumping out reggae sounds. You just may catch Clive's fan Lenny Kravitz taking in the scene. Clive's is great for take-out but just as nice for a midafternoon stop to take it easy.


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Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal
This study has been completed.
Hospital Clinic of Barcelona
Information provided by:
Hospital Clinic of Barcelona
ClinicalTrials.gov Identifier:
First received: October 2, 2008
Last updated: NA
Last verified: October 2008
History: No changes posted
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study has been completed.
|Study Completion Date:
|No date given
|Primary Completion Date:
|October 2008 (Final data collection date for primary outcome measure)


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Best Of :: Food & Drink
The owners of That's Italiano pride themselves on the fact that everything in the tidy, exposed kitchen is made on the premises. In fact, they claim to do everything on-site "except butcher the chickens."
But who's squawking? The tantalizing menu lists everything you'd expect to find in an Italian mom-and-pop operation -- 13 pastas and eight entrees, plus salads, focaccia, pizza and calzones. It's got all our favorites, from spaghetti topped with thin-sliced homemade sausage and mild tomato sauce goosed with fresh, whole-leaf herbs; to chicken parmesan with breast pounded so perfectly thin we could slide it under a door. Pillowy-crusted pizza's another pleaser, topped with handmade mozzarella so silky it looks like butter above our favorite "special" toppings of sausage, ham, salami and prosciutto.
The eatery's packed with the friendly charm you expect in a neighborhood trattoria, with crisp white and blue tablecloths, a seaside mural and clouds painted on the ceiling. Italian acoustical music fills the air, and there's even live talent on weekends.
The owners aim to please and do their best to honor our special requests. Just hold the flying feathers, please.
Don't expect to find any piatas, colorful serapes or beer-touting sombreros here. This reproduction of a 19th-century Mexican ranch house is impeccably tasteful, down to the last carved, dark wood chair, white linen tablecloth and soaring silk flower arrangement.
But the lavish decor is just visual garnish for the most upscale Mexican food the Valley has to offer. Chips? No way, José! Instead, opt for high-end appetizers, like pasteles de jaiba (plantain-crusted crab cakes with chipotle oil) or tamal de pato (braised duckling tamale with orange honey masa and tomato nixtamal sauce). And don't even think of combo plates with entrees such as cochinillo asado (spit-roasted suckling pig stuffed with chorizo) and mero al sartén (pan-seared grouper with grilled cucumber pico and veracruzana sauce).
Whatever your choice, save room for dessert -- like La Hacienda's signature capirotada (fried three-milk bread pudding with port macerated berries and star anise ice cream).
When the weather's nice, request a table near the French doors, which collapse together for calming views of a courtyard dotted with palm trees, a bubbling fountain and strolling mariachis.
A glance at El Bravo's menu is deceptively ho-hum -- beef burros, chicken tacos, chimichangas, combo plates.
Don't be fooled. This food may sound like Taco Bell, but it tastes authentic. Everything is made fresh in the restaurant's open kitchen, and owner Carmen Tafoya isn't shy about sneaking in the spices where appropriate -- her red chile beef packs a mean left hook. The tanker-size tamales are fluffy; the chicken green corn positively floats off the plate, studded with lots of fresh kernels, peppery white-meat chicken and cheese under green chile sauce.
Both sides of the border can rejoice!
We're not morning people. We admit it. If God had meant for people to be awake in the morning, he wouldn't have had to create alarm clocks.
There's little that can convince us to leave our warm bed at the crack of dawn (has anyone else noticed that a mattress never fits so perfectly as it does just before we're forced to leave it?).
Good chorizo is one of those things, though, that rouses our head from the pillow, summons us to our slippers, and gets us to greet the day with a smile.
That's a pretty big accomplishment for just $4.50, but La Cabana pulls it off with its huevos con chorizo meal (to be accurate, the dish should read chorizo con huevos, such is the generous ratio of highly spiced chile-vinegar-garlic sausage to egg). The sausage is a wonderful jump-start to the day -- dry, salty, smoky -- and only gets better when we fold it into a corn tortilla spread with gorgeously runny refried beans.
Sometimes we mix it up, adding thin guacamole from the on-ice salsa bar, alternating munches with bites of cool lettuce, radish, and cucumber drizzled with lime. A cold horchata drink is just the thing, too, tasting comfortingly like wet tapioca and soothing some of the chorizo burn.
The only problem? After finishing the plate, we're so stuffed, we want to go right back to bed.
Who'd have thought that something so simple could be so good?
While other places may fry their fish in batter and pile on the sauces and cheese, chef-owner Rita Aramburo leaves the Mrs. Paul's approach to seafood tacos to others.
The catfish here is remarkably flavorful, sautéed in chunks with tomato, onion and a touch of seasoning. The vegetables are soft, warm, and cooked down so their juices blend with the firm fish -- so savory, and much better than the cold veggie chop we find in other tacos around town.
The uncomplicated mix is wrapped in a grilled corn tortilla, with nothing more to add than a squeeze of lemon and a splash of Rita's killer spicy salsa.
Rita's fish tacos? We're hooked.
Sure, we could tell you that the seafood cocktails here are so fresh that you'll swear you can hear sea gulls overhead.
Or that the Sea of Cortez cookery (try the garlic shrimp with rice and beans) is so authentic that you'll actually think you can smell the salty ocean air.
Or that a visit to San Carlos Seafood is so enjoyable that you'll believe you've been magically transported to a cantina on a south-of-the-border shore.
Instead, we'd just like to steer you to the most delicious Mexican-style seafood the Valley has to offer, served up in a no-frills joint on a seedy stretch of East McDowell. But if you want to pretend that freeway overpass right down the road is an Aztec temple, be our guest. As for us, we'll have another ceviche tostada.


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I wouldn't own any of the three. Check out budsgunshop.com, they got new no-lock S&W 642's for $361. Great deal on a quality piece.
This is a discussion on .45 ACP or .357 Small Concealed Gun within the Defensive Carry Guns forums, part of the Defensive Carry Discussions category; I am looking at a small carry guns my three options are: 1)Used or New AMT Backup(I figure $300-525) .45 ACP 2)New Bersa Thunder (I ...
I am looking at a small carry guns my three options are:
1)Used or New AMT Backup(I figure $300-525) .45 ACP
2)New Bersa Thunder (I figure $300-$520) .45 ACP
3)New EAA Windicator 2" snubby(I figure $275-290).357 Magnum
What do you Ya'll think?
Anymore great options?
"Those who would give up essential Liberty, to purchase a little temporary Safety, deserve neither Liberty nor Safety. "
(Benjamin Franklin)
'God made man and woman; Colonel Colt made them equal'." (Ann Coulter)
I wouldn't own any of the three. Check out budsgunshop.com, they got new no-lock S&W 642's for $361. Great deal on a quality piece.
The EAA Windicator .357 was my first revolver. It was the price that convinced me to buy it. It was the gun itself that convinced me to trade it.
Hurt my hands to shoot the darn thing. Even .38's were painful to practice with. Not likely to ever regret being rid of it.
Look into Charter, or maybe a used S&W before you spend good money on a "pot-metal" brick.
It weighs a ton for "small carry gun" you say you're looking for.
If your budget is that tight, then you gotta work with what you have.
I found this web review not long after I bought mine. He has a somewhat more favorable opinion of the "pugsley".
The EAA Windicator (aka Pugzley)
The views expressed above are the opinion of the poster and may or may not be total bunk.
Viewer discretion is advised.
Smith j-frame or ruger lcr/sp101 revolver
as for the ,45 some people have had success with the AMT's here... otherwise there are the Kahr pm45, I am not even going to recommend the taurus.
SP101 for the .357. If going for a 45, check out the Glock 36.
NRA Member
Glock 26 XD9sc
Ruger SR9c Ruger LCP
45ACP: Colt Officer's Model or Defender if you like SA pistols
Glock 30 or 36
9mm: Glock 26 or Ruger SR9 Compact
357Mag:Ruger SP101
Just my $.02 and some other options for you. Good Luck in making a decision.
"We deal in lead friend">Steve McQueen The Magnificent Seven
82d Abn(1983-86)OIF 2007-08
Glock 19&26/ Colt Gov't & OM/Ruger SP101
Retired NYS LEO / NRA Life Member
"no kidding,gun slinging,spurs hitting the floor"
The name brands have parts availibility, customer service, dependability, and hold their value. I like S&W and Ruger for holstered front pocket snubbies, and single stack 45s from Kimber, Springfield, Glock, or Kahr for IWB. Take your time and do some comparisons at the gun counter, if you can't rent them to shoot.
Liberty, Property, or Death - Jonathan Gardner's powder horn inscription 1776
Tu ne cede malis, sed contra audentior ito.
("Do not give in to evil but proceed ever more boldly against it.")
-Virgil, Aeneid, vi, 95
Of the 3 you mentioned, I'd go with the Bersa. They build a quality gun at a budget price.
Freedom doesn't come free. It is bought and paid for by the lives and blood of our men and women in uniform.
USAF Retired
NRA Life Member
"Violence is seldom the answer, but when it is the answer it is the only answer".
"A nation of sheep breeds a government of wolves".
Trust in God and keep your powder dry
"A heavily armed citizenry is not about overthrowing the government; it is about preventing the government from overthrowing liberty. A people stripped of their right of self defense is defenseless against their own government." -source
I ditto archer51's Bersa choice by far the superior gun of those due to reliability record and overall quality * The Bersa Firearms line is probably the best in their price range from all the comparisons i've read * Often it depends on how much you want to spend so enjoy your decision and post what you get for us.....
I know it wasn't on your list, but I've seen LCR's listed brand new for 399.00
I agree with a couple others here, of the three choices you listed, I'd go with the Bersa. I just picked up a used one last month and they seem to be well made pistols. I had an issue with my ejector snagging the rims of my cartridges coming out of the magazine, but I fixed it with a little filing and it cycles fine now. I understand that was only a problem with the older pre-Pro models like mine anyway and the currrent models are problem free.
S&W 640 for .357 Mag and Glock 36 for .45


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Pomegranate-glazed salmon/
This is Week #1 of my 2011 cooking challenge! Woooo! Click here to view all recipes from this challenge. All recipes created for this challenge come from the Food and Wine Annual Cookbook 2010: An Entire Year of Recipes.
This was a good recipe to start with because, well, it was good! Delicious, actually. And so very colorful and festive. It was a healthy way to start the new year!
First, you will need to prepare a marinade for the salmon. Plan on at least an hour for marinating.
1/4 cup soy sauce
2 Tbsp. extra virgin olive oil
2 Tbsp. fresh lemon juice
2 Tbsp. fresh lime juice
2 Tbsp. agave nectar (this wasn't available at the store by our house, so I used honey as a replacement)
4 smashed cloves of garlic
1 Tbsp. finely grated ginger
1 teaspoon kosher salt
1 teaspoon freshly ground white pepper
Mix well and place in a shallow baking dish. Add eight 6-oz. skinless salmon fillets to the dish and coat with the marinade. Cover and refrigerate for 1 hour, turning fish a few times.
While the salmon is absorbing all of those delicious flavors, prepare the glaze.
In a medium bowl, combine:
1/4 cup pomegranate molasses (you can make your own or purchase it)
2 Tbsp. agave nectar (again, I used honey)
2 Tbsp. soy sauce
2 minced cloves of garlic
1 Tbsp. finely grated ginger
1 Tbsp. finely grated lime zest
Mix well.
When the salmon is done marinating, preheat your broiler.
Transfer the salmon to a rimmed baking sheet. Season with salt and brush with half of the glaze. Broil 4 inches from the heat source for 3 minutes, until the fillets begin to brown.
Brush with the remaining glaze and broil for 3 additional minutes, until salmon is richly glazed and just cooked through.
Serve with Armenian Rice.
Garnish with shelled edamame and pomegranate seeds.
Isn't it pretty?


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Legal Professional: Build Your Business
I hand a work related injury which resulted in surgery and kept me out of work for over 8 monhts. Upon reaching MMI, I was released to full duty and currently I am employed by the same employer. I don't know if my Orthopedic Surgeon gave me an MMI rating or not but the WC Insurance company did not pay me out a lump sum. They did pay my benefits and medical bills until I reached MMI but since than I have not heard from them. Are they required to pay me a sum of money depending on my MMI rating? It only has been 3 months since I was released to full duty so I believe I still have time to be entitled to something?
It is not a question of being at MMI. The doctor has to come up with some estimate of your percentage of impairment and/or loss of wage earning capacity and explain why he has the opinion that he has. For example, let's say that he opines that you have a 2% whole body loss or 10% loss of use of your leg. Those percentages might translate into some kind of lump sum award.
Some states would only award a lump sum if you had a loss of wage earning capacity. I don't know the specific rule in NJ, but the fact that you returned to full duty (and presumably at same pay) with your date of injury employer, might work against you if that is the rule in your state.
It can't hurt to have a consultation with a local WC attorney. Most of the time, any attorney fee is either paid by the carrier or deducted from your award. Ergo, it is unlikely that you would have to come up with any money out of pocket solely for an initial consultation.
Since much of this stuff really is state specific, you might want to consult a local WC attorney for guidance. I don't believe that any follow these boards.
This has been asked/answered in another board....including the statutes relative to the situation.
The insurance company may make a voluntary payment, or they may not. If they decide to do so, they will likely send you to an examining doctor for a permanent partial disability rating and will then likely pay you the percentage of disability that their doctor gives you. However, the insurance company is not obligated to do this. If they do, their doctor will most certainly come to a disability rating that is less than you deserve. If you want to continue to represent yourself, you should accumulate your own treating medical records and get an examination with a doctor who commonly examines injured workers so that you can obtain your own permanent partial disability rating. Then you should file a formal Claim Petition with the Division of Workers Compensation. You really should hire a Workers Compensation attorney for this. It sounds like you have a bad injury. The attorney will make sure you get true value for your injury. It shouldn't cost you any money up front to hire the attorney. At the end of the case his fee would likely only be 8% of your settlement amount. Remember that the Statute of Limitations for your case runs 2 years from the date of last WC insurance payment, which for your case would likely be 2 years from the last medical treatment session paid for by he WC carrier.
you can read the entire thread here http://www.workerscompensationinsurance.com/forum/showthread.php?46303-Have-Reached-Mmi-Now-What
you can read the entire thread here http://www.workerscompensationinsurance.com/forum/showthread.php?46303-Have-Reached-Mmi-Now-What


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Pros & Cons Of Working On The Road
the stressEven though the money can be good, it seldom makes up for the grind that travel exerts on the body and mind. People who work on the road most of the year can feel like automatons as they navigate through airports, live out of suitcases, and subsist on room service and fast food. Despite the thrill of a new city, customer and project, constant travel is an exercise in exhaustion.
"It can be tough to go from city to city without a break. To be honest, there are times when I forget what time zone or even country I happen to be in. That is what regular travel on the job can do: Distort your sense of reality and in general, mess with your mind. My life is an invariable whirl of planes, taxis, hotels, and airports. I hate to sound ungrateful because I do like my job, but there are moments when I want to trade it in for a cushy corner office. Because of the relative urgency of the projects I work on, I have to be on a constant state of alert. A part of me is never quite in 'relax' mode, if you know what I mean."
the connectionsWhen your mandate is to work on critical assignments abroad, you come into contact with important players who can open up doors to lucrative career prospects. If you have the savvy to network with and finesse people with clout and influence, the sky can be the limit. Big firms tend to cull important hires from a pool of familiar faces. Keep that in mind if your goal is to make a career move to a foreign country.
"I get a fair amount of job offers on the road, the bulk of which come to me over drinks or dinner. Customers that I work with try to lure me away from my current employer from time to time with promises of better pay and perks. Proposals just do not pour in like that when you work from the home office."
the opportunity costWhen you spend an inordinate amount of time away from home, you miss out on a lot; special occasions, social excursions, quality time with family, and the chance to relax at home. We do not appreciate our leisure time when we have it in abundance. But the more you travel, the more you realize how precious it is.
"In the past year I have not been able to attend several birthdays, engagement celebrations and Easter dinner with my parents. The guilt you feel is awful, although I have no choice in the matter. I also made a big purchase with my first home last summer. However, it was hard to buy, insure, decorate, and furnish it because I was sent to Asia in the middle of the acquisition process. My long-distance bill during that trip was insane. That kind of hassle is the worst part of the job."
CJ also admits that relationships are tough to maintain when your job demands regular travel.
"Not many women can cope with my lifestyle. When I decide to settle down, either my significant other will be the most patient woman on earth or I will have to stop the crazy travel schedule altogether. I need a few years before I can give it up though."
Definite food for thought as you consider a career with travel demands.


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Fifty Shades of Grey sparks unexpected marketing mania
Wildly popular erotica trilogy Fifty Shades of Grey has inspired publishers, record labels, sex shops and even crafty parents to submit – to the desire to cash in, that is.
The trio of novels by British writer E.L. James that has so far sold 32 million copies in the US has spawned a legion of fans clamouring for anything and everything Grey-related. And businesses are aiming to meet that demand.
Manhattan sex shop Babeland co-founder Claire Cavanah said after the final book in the trilogy was released in the US in January, customers "were asking for specific toys that they had read about", but when the trilogy was re-released in April, "the product sales started to really spike".
Since then Cavanah noticed a seven-fold increase in demand for a particular sex toy featured in a scene between the book's two main characters, the dominant Christian Grey and ingénue Anastasia Steele.
The store also sells special Fifty Shades kits and hosts Fifty Shades-themed workshops that teach the mostly female attendees how to use the 'toys', but Cavanah said that was not the only curiosity – "They also just want to get together and see each other."
Fans have also been offered Fifty Shades-themed fashions, accommodations and, more recently, an official music album.
Fifty Shades of Grey: The Classical Album, featuring Bach and Chopin, is the only spin-off item James has so far endorsed.
Released by EMI with tracks James personally selected, it debuted at No. 1 on the US classical charts in September. The album resulted after another Fifty Shades compilation series hit No. 1 in July on iTunes, said EMI Classics Vice President Wendy Ong.
Asked about the other spin-off products at the New York album launch, James told reporters: "All of this has been a huge shock to my system. If people want this stuff, why not? If we can get it out there to people, then that's a good thing."
Yet some eyebrows have been raised at other efforts by entrepreneurs, including one British hotel that replaced its nightstand Bibles with copies of Fifty Shades, with the Damson Dene Hotel owner Jonathan Denby saying the hotel wanted to provide "something that people actually want to read".
Even baby clothes have been subjected to the marketing blitz. One Toronto couple emblazoned baby onesies with sayings like "9 months ago my mommy read 50 Shades of Grey" and "All Mommy wanted was a night with Mr Grey".
The feedback has been mixed, but seller Kyle Lawley said that he and his wife had been surprised by strong sales. "Some people say 'it's taboo, I'd never put my kid in that', and others say it's clever, it's funny, it's humorous," he said.
Publishers are also looking to cash in on the trend. Penguin's Diary of a Submissive: A Modern True Tale of Sexual Awakening, has been marketed by directly comparing it to Fifty Shades, which was initially self-published on the internet.
Other publishers, such as those of racier versions of literary classics such as Jane Eyre, and Sherlock Holmes, say the link is less transparent.
A new version of Wuthering Heights will be released in October featuring Catherine and Heathcliff engaging in bondage.
The books publisher, Total-E-Bound founder Claire Siemaszkiewicz, said James's series made it easier for sexed-up books to gain a market foothold but dismissed criticism that the classics have been sullied, saying they have been brought "to a new generation of reader".
A Fifty Shades film is also in the works but James has vowed she will not write any more books for the series. Still, her next book should whet fiction fans' appetites: "It's an erotic tale, yeah. That's all I'm going to say about it," she said coyly.
See our Comments Policy Comments are submitted under the express understanding and condition that the editor may, and is authorised to, disclose any/all of the above personal information to any person or entity requesting the information for the purposes of legal action on grounds that such person or entity is aggrieved by any comment so submitted. Please allow some time for your comment to be moderated.


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Welcome to LovePuppies Brownies
We are a scrumptiously simplistic gourmet brownie bakery, purely bred in Austin, Texas. LovePuppies Brownies are available in a variety of unique flavors for every occasion. Our brownies contain the highest quality ingredients including locally sourced eggs, imported Mexican vanilla and most importantly, dark chocolate.
While we love our canines, LovePuppies Brownies are people-only treats.


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Monday, May 24, 2010
5:30 p.m.
City Council Conference Room
City Hall at 420 Litho Street
Agenda and Packet (pdf 1.1mb)
Each agenda item will be considered in the following manner: 1) Staff will provide a presentation/overview; 2) the Housing Element Committee (HEC) will discuss the item; 3) the public may comment on the item; and 4) the HEC will discuss the item and take action.
The HEC may, at its discretion, consider agenda items out of the order in which they are listed. The public may comment on any item on the agenda that has not previously been subject to public comment. To give everyone an opportunity to be heard and to ensure the presentation of different points of view, the Committee requests that members of the audience who speak: 1) Always address the Chair; 2) State his or her name and address; 3) State views succinctly, and; 4) Limit comments to three minutes.
1. Call to Order
Chair Linda Pfeifer (City Council Rep)
Vice-Chair Joan Cox (Planning Commission Rep)
Mike Kelly (City Council Rep)
Stan Bair (Planning Commission Rep)
Steve Flahive (City Resident)
Chris Visher (City Resident)
Carolyn Kiernat (City Resident)
Joel Paul (City Resident)
Vacant (City Resident)
2. Public Comment on Items Not on Agenda
3. Approval of Minutes – April 26, 2010 and May 10, 2010 (5 minutes; end at 5:35pm)
4. Introduction of Planning Intern Kayla Platt (5 minutes; end at 5:40pm)
5. Review and Approve Housing Constraints Section (10 minutes; end at 5:50 pm)
6. Subcommittee Reports (40 minutes; end at 6:30pm)
a. Liveaboards (Pfeifer and Cox)
b. Apartment Units (Flahive and Bair)
c. Second Units (Schinsing and Platt)
d. Vacant Parcels (Kelly and Kiernat)
7. Communications
a. Staff
- Report on Availability in August
b. HEC Members
8. Agenda Topics for Next Meeting
-Discussion regarding Public Workshops
9. Adjourn – Next Meeting: Monday, June 14, 2010
Agendas are available at the Community Development Department and posted at least 72 hours prior to the meeting at the entrance to City Hall, 420 Litho Street. Recordings of the meetings are maintained at the Community Development Department.
Special Needs - In compliance with the Americans with Disabilities Act (28 C.F.R. 35.102-35.104, ADA Title 11), if you need special assistance to participate in a Housing Element Committee meeting, please call 289-4128. Notification 48 hours prior to the meeting will enable the City to make reasonable arrangements to ensure accessibility to this meeting.
City of Sausalito
Community Development Department
420 Litho Street
Sausalito, CA 94965
(415) 289-4128 | www.ci.sausalito.ca.us
Jeremy Graves, Community Development Director
Mary Wagner, City Attorney
Lilly Schinsing, Associate Planner-Project Manager
Heidi Burns, Associate Planner
Alison Thornberry, Assistant Planner
Kayla Platt, Planning Intern
Alberto Viana, Administrative Aide I
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Join Date: Oct 2003
Posts: 1,203
Monday, June 4, 2012 at 03:06PM
I'm late to the eagle conversation, but here is a pic of the pair who nests in the forest around where I work. I have nicknamed them after two of our maintenance men who are always together, but only one of them is actually bald
And RCW is correct, the ban on DDT has meant that all of those birds of prey have made strong recoveries. The bald eagle was removed from the federal list of threatened and endangered species in 2007 but it is still protected under the Bald and Golden Eagle Protection Act, the Migratory Bird Treaty Act, and the Lacey Act.
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