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The University of Chicago Medicine
A future without seizures New hope for children and adults with severe, uncontrolled epilepsy
Inspired approach to treating stage 4 head and neck cancer without surgery Kidney-pancreas transplants expand options for patients with diabetes
Pediatric Focus
Neuroblastoma team offers world-class expertise, latest therapies
The University of Chicago Medicine and Biological Sciences has been at the forefront of medical care, research and teaching for more than 90 years. Located in historic Hyde Park on the South Side of Chicago, the University of Chicago Medicine and Biological Sciences includes: Patient Care Bernard A. Mitchell Hospital (adult) Comer Children's Hospital Duchossois Center for Advanced Medicine Numerous outpatient locations throughout the Chicago area
DEAR COLLEAGUES, This is an exciting time for the University of Chicago Medicine as we expand the horizons of health care and our own facilities. In June, we opened the University of Chicago Medicine Comprehensive Cancer Center at Silver Cross Hospital in New Lenox, Ill. The new outpatient diagnostic and treatment center brings University of Chicago Medicine cancer specialists and their advanced and investigational therapies into a community hospital setting. We will follow that expansion with another on our Hyde Park medical campus, where our new hospital opens in February. January. Like Theour 10-story, cancerstate-of-the-art center, the 10-story, facilitystate-of-the-art combines the latest facility technologies combines thewith latest innovative technologies architecture, with innovative an inspiring architecture, setting for an our inspiring physicians setting asfor they our physicians provide complex as theycare provide expertly complex and compassionately. care expertly and compassionately. Throughout this edition of Inspired, the strength of that care is made clear, as are our advances in the treatment of hypertension, epilepsy, head and neck cancer, pediatric neuroblastoma, and other complex and specialty cases. We are truly proud of the expansion taking place in our programs and facilities, and we're equally excited about our expanding relationships with physicians in our community as well as research colleagues worldwide. We look forward to building on those now and in the future.
Teaching Programs Pritzker School of Medicine Master's and doctoral degree programs Postdoctoral programs Research Medical and basic science units Among our many honors and acknowledgements: 12 Nobel laureates; ranked 10th of all U.S. medical schools; one of only 41 National Cancer Institutedesignated comprehensive cancer centers; ranked second in nation for National Institutes of Health grant support per researcher. University of Chicago Medicine and Biological Sciences Executive Leadership Kenneth S. Polonsky, MD, Dean of the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical Affairs for the University of Chicago Sharon O'Keefe, president of the University of Chicago Medical Center Richard Baron, MD, dean for clinical practice and chair of the University of Chicago Medicine Department of Radiology T. Conrad Gilliam, PhD, dean for research and graduate education, Biological Sciences Division Holly J. Humphrey, MD, dean for medical education, Pritzker School of Medicine Inspired is published quarterly by the University of Chicago Medicine.
Kenneth S. Polonsky, MD Dean, Biological Sciences Division and the Pritzker School of Medicine Executive vice president for Medical Affairs for the University of Chicago
Editors: Anna Madrzyk Ginny Lee-Herrmann Email us at: email@example.com Design: Group Chicago Contributing writers: Jamie Bartosch, Tanya Cochran, Megan Doherty, Elizabeth Gardner, Darcy Lewis, Gretchen Rubin, Anita Slomski and Matt Wood
A Brand for the 'Forefront of Kids' Medicine'
The University of Chicago Medicine Comer Children's Hospital introduces a new, updated logo, strengthening its connection to the University and re-emphasizing its place as the center for children's specialized health care in Chicago.
Sign up for a CME program at our new hospital. — Back cover
Committed to care and compassion Medical student Laura Blinkhorn pulls weeds outside a senior housing complex during the University of Chicago Medicine's 10th annual Day of Service and Reflection in May. Blinkhorn, a fourth-year student at the Pritzker School of Medicine, was among more than 200 volunteers during the Urban Health Initiative event, which fosters ties between the medical center and its South Side neighbors. "As a medical student, it's important to know the community, where our patients come from," Blinkhorn said.
Contributing photographers: David Christopher, Dianna Douglas, Dan Dry, Jean Lachat and Bruce Powell Address: The University of Chicago Medicine 5841 S. Maryland Ave. Chicago, IL 60637 The University of Chicago Medicine Comer Children's Hospital 5721 S. Maryland Ave. Chicago, IL 60637 Physician Referral Line: 1-800-824-2282 Appointments: 1-888-824-0200 Follow the University of Chicago Medicine on Twitter at twitter.com/UChicagoMed or visit our Facebook page at facebook.com/UChicagoMed. You can read more about our news and research at uchospitals.edu/news and at sciencelife.uchospitals.edu. This publication does not provide medical advice or treatment suggestions. If you have medical problems or concerns, contact a physician who will determine your treatment. Do not delay seeking medical advice because of something you read here. For urgent needs, call 911 right away. Read Inspired online at uchospitals.edu/inspired.
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Hypertension center earns 'comprehensive' designation
Collaborative care for complex aortic disease
The American Society of Hypertension (ASH), the nation's largest organization of hypertension specialists, has designated the University of Chicago Medicine as a Comprehensive Hypertension Center, the first in the country. This George Bakris, MD designation is the highest level of formal recognition for academic medical centers that demonstrate expertise in treating patients with complex hypertension and its comorbidities. The University of Chicago Medicine Comprehensive Hypertension Center is directed by George Bakris, MD, a nephrologist and board-certified ASH hypertension specialist. "The Comprehensive Hypertension Center designation distinguishes the University as a center of excellence for hypertensive diseases," said Bakris, who also is the immediate past president of ASH. The center offers individualized care through inpatient and outpatient consultation to patients who have hypertension in addition to other health conditions, including early kidney disease, diabetes and high risk for heart attack or stroke. The center also is a national leader in hypertension research. Bakris is the national co-principal investigator of the Symplicity HTN-3 trial on refractory hypertension and principal investigator of the AMETHYST trial dealing with potassium management in people with kidney disease and hypertension. He is also on the steering committee of two other international kidney outcome trials.
T he University of Chicago Medicine aortic diseases program provides
multispecialty, state-of-the-art care for patients with complex aortic problems. "We feel we offer something very unique in the whole Midwest," said vascular surgeon Ross Milner, MD, who co-directs the program with cardiac surgeon Mark Russo, MD, MSc. The team includes experts from several specialties — vascular and cardiac surgery, general and interventional radiology, anesthesia, imaging and nursing — working collaboratively to treat patients with aortic disease. The team offers leading-edge care, including minimally invasive and hybrid surgery, for aneurysms, dissections, congenital aortic diseases such as Marfan syndrome and other conditions. In February, the University of Chicago Medicine was the first hospital in Chicago to perform a transcatheter aortic valve replacement (TAVR) outside of a clinical trial setting. "This nonsurgical treatment clearly has been shown to provide improved survival and better quality of life for patients who are poor candidates for surgery and for whom no options previously existed," Russo said. uchospitals.edu/specialties/ aortic
uchospitals.edu/specialties/endocrinology/ hypertension.html
By the Numbers
pediatric cochlear implant surgery performed in spring 2012
Cordero Rice, 1, hears for the first time. The toddler, deaf since birth, was the recipient of the University of Chicago Medicine's 100th pediatric cochlear implant surgery, performed by surgeon Dana L. Suskind, MD, left, and her team.
young physicians chosen for prestigious Bucksbaum Institute fellowships on enhancing the doctor-patient relationship
Monica Peek, MD, MPH, internal medicine specialist and a fellow of the new Bucksbaum Institute for Clinical Excellence, is studying whether removing racial and cultural obstacles in doctor-patient interactions will reduce health disparities among African Americans with diabetes and other chronic diseases.
Average number of clinical trials conducted at the University of Chicago Medicine each year
+ Educational Opportunities Register for CME events at cme.uchicago.edu.
Controversies in the Management of Complex GI Cancer Patients
All day, September 7 Ritz-Carlton Chicago 160 E. Pearson St., Chicago
University of Chicago Medicine Comprehensive Cancer Center at Silver Cross Hospital Inaugural Symposium
7:30 a.m. to 3:30 p.m., September 15 1850 Silver Cross Blvd., New Lenox, Ill.
Orthopedic surgeon specializes Chicago Breast Reconstruction in minimally invasive surgery Symposium All day, September 28 for sports injuries Ritz-Carlton Chicago 160 E. Pearson St., Chicago
Comprehensive Cancer Center at Silver Cross opens The new University of Chicago Medicine Comprehensive Cancer Center at Silver Cross Hospital brings University of Chicago cancer specialists and their advanced treatment programs to a convenient community setting. The $21.6 million, 20,000-square-foot outpatient cancer treatment center — a joint venture between the University of Chicago Medicine and Silver Cross — opened June 25 in New Lenox, Ill.
The University of Chicago Medicine Comprehensive Cancer Center at Silver Cross Hospital offers leading-edge treatments not typically available in a community hospital setting.
The cancer center offers state-of-the-art chemotherapy and radiation therapy and access to innovative clinical trials. Technology includes the TrueBeam next-generation linear accelerator, which delivers targeted radiation therapy to provide the safest and most precise treatments. TM
Other services include cancer screenings, patient support groups and a resource center. University of Chicago Medicine physicians will provide gynecologic oncology services at Silver Cross Hospital in conjunction with the center. ucmcancer-sch.org
Mark your calendar Advances in Treating Oral Cancers
Chicago, fall 2012
Advances in Kids' Medicine
Chicago, fall 2012 and spring 2013 University of Chicago Medicine physicians are available to present in-office CME courses in greater Chicagoland and Northwest Indiana.
at the forefront of cancer care and discovery
For information, please contact Carrie Sota, firstname.lastname@example.com.
More than 350 cancer clinical trials
210 University of Chicago laboratory and clinical scientists studying cancer
The University of Chicago Medicine Physician Relations Program
92 presentations by University of
Chicago Medicine physicians at the recent American Society of Clinical Oncology (ASCO) conference
Please contact us by phone or email with any request. We are here to serve you. Physician Relations Program 1-773-234-2036
1of 41 National Cancer Institute-
Carol Marshall, Director 1-773-702-9205 email@example.com
designated Comprehensive Cancer Centers
Carrie Sota, Assistant Director Serving Northwest Indiana 1-773-892-2120 firstname.lastname@example.com
One floor of the 1.2-millionsquare-foot new hospital opening in early 2013 devoted to cancer care
Anthony Turner, Associate Serving the South and Southwest Suburbs 1-773-729-0822 firstname.lastname@example.com Demetria Avant, Associate Serving the Western Suburbs 1-773-717-0458 firstname.lastname@example.com
1of 11 National Cancer Institute Breast Cancer Specialized Programs of Research Excellence (SPOREs) in the United States
Dionne Meekins-Michaud, Associate Serving all regions for Pediatrics 1-773-717-0457 email@example.com
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RESEARCH NEWS The buzz on beehive extract An over-the-counter natural remedy derived from beehives arrests the growth of prostate cancer cells and tumors in mice, according to a new study. The active ingredient in honeybee hive propolis shuts down tumor cells' system for detecting sources of nutrition, University of Chicago Medicine researchers found. "So it doesn't kill the cancer, but it basically will indefinitely indefinitelystop stop prostate prostatecancer cancer proliferation," proliferation,"said said genomics genomicsresearcher Richard researcher Baker Richard Jones, PhD, Bakersenior Jones,author PhD, senior of the study authorinofCancer the study Prevention in Cancer Research. Prevention Research. The innovative The innovative protein-onomics protein-onomics technique technique the team developed the team developed may be used may to be study used to study the mechanisms the mechanisms of other of promising other promising natural natural remediesremedies that previously that previously would have would been have been too expensive too expensive to test.to test.
Nicolle Rager, National Science Foundation
'Top-down' treatment for Crohn's A large-scale study of medical claims data shows that introducing sophisticated biologic therapies early improves Crohn's disease outcomes. Traditional treatment focuses on a "step-up" strategy, starting with such simpler and cheaper medications as 5-ASAs and corticosteroids and ramping up to targeted biologic therapies. But patients treated with a "top-down" approach that reverses that order were less likely to need steroids, lose response to their biologic therapy and require surgery. "We're essentially reversing the management strategy in Crohn's disease," said David T. Rubin, MD, co-director of the University of Chicago Medicine's Inflammatory Bowel Disease Center. New target for cancer therapy Manipulation of two biochemical signals that regulate the numbers of mitochondria in cells could shrink human lung cancers transplanted into mice, researchers from two Chicago medical centers reported in FASEB. "We found that human lung cancer cell lines have an imbalance of signals that tilts them toward mitochondrial fission. Lung tumors from patients here at the University of Chicago displayed these same mitochondrial
abnormalities (excess DRP-1, deficient mitofusin-2), an important sign that this observation may be clinically relevant," said Stephen L. Archer, MD, lead author from the University of Chicago Medicine. Boosting Boostingthe the fusion signal or blocking the fission signal through various methods, including gene therapy, caused tumors to shrink drastically. "We believe this provides a promising new approach to cancer treatment," Archer said. Take 115 tablets… Providing tablet computers to medical residents increases their efficiency, reduces delays in patient care and enhances continuity of care, according to a report from the University of Chicago Medicine in the Archives of Internal Medicine. In November 2010, the medical center was the first in the country to provide residents with tablet computers on a large scale, supplying iPads to all 115 internal medicine residents. Surveyed in 2011, more than three out of four residents said the portable computers freed them up them to spend up to spend more time moreon time direct on direct patient care. patient Thecare. study Thealso showed study also residents showed using residents tablets using submitted tablets submitted 5 percent 5 percent more orders morebefore orders7before a.m. rounds, 7 a.m. rounds, and 8 percent and 8 percent more orders more orders before hand-offs. before hand-offs. More food, fewer pills An unusual clinical trial at the University of Chicago Medicine is studying whether a drug for advanced prostate cancer might be just as safe and effective, but more convenient and less expensive, if taken at a much lower dose with food. GI absorption of Zytiga (abiraterone acetate) is more affected by food than any other marketed drug labeled to be taken on an empty stomach. Five times as much of the drug is taken up with a low-fat meal; up to 10 times as much with a high-fat meal. "Taking one pill with a meal, rather than four pills on an empty stomach, is much more convenient for patients, so it may improve compliance," said Russell Szmulewitz, MD, director of the study. The The recommen results could affect future dosage recommendations, potentially saving patients thousands of dollars a month. Read more at uchospitals.edu/news.
< Meet Our Faculty >
Mitchell C. Posner, MD, is chief of general surgery and surgical oncology and medical director of clinical cancer programs at the University of Chicago Medicine. He is an internationally recognized expert on upper gastrointestinal cancers, including pancreatic, esophageal, stomach and liver cancer. Posner is chairman of the Gastrointestinal Committee of the American College of Surgeons Oncology Group, the only national, surgically focused cooperative dedicated to oncology clinical trials. What are your goals as director of clinical cancer programs at the University of Chicago Medicine? Providing easy access to what is rated as the No. 1 cancer center in Chicago and one of the leading cancer centers in the country, communicating with referring physicians in a more standardized fashion and offering an ideal patient experience. How quickly will a new patient of the GI cancer program be seen? We strive to see patients within a week of their initial call, and I think we're very good at that. Our new goal is to schedule a visit within three days. We have a dedicated intake team that coordinates appropriate appointments with medical oncology, surgical oncology, gastroenterology and radiation oncology. They are experienced, knowledgeable and able to navigate patients in a very seamless way through a complex process. Are there any promising treatments for pancreatic cancer? Clearly we've moved the needle. The ability to deliver chemotherapy regimens that have more activity than regimens we used even a couple of years ago is significant. Most importantly, it's well known that surgeons and hospitals with high volumes have better outcomes. From a surgical perspective, since surgery is still the only curative treatment, our ability to do these procedures with lower morbidity and very low mortality is compelling for both patients and care providers. What inspires you about the University of Chicago Medicine? Great people in a great setting that has the perfect balance of research, clinical excellence and the training of the next generation of both academic and clinical leaders. That's our mission. That's what inspires me.
Stopping Nathan's seizures Epilepsy program provides definitive diagnoses, multidisciplinary care for children and adults
Michael Kohrman, MD, and Nathan Kalina
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ive-year-old Nathan Kalina is a "miracle child," says his mother, Megan. Diagnosed with myoclonic-astatic epilepsy (Doose syndrome) at age 3, Nathan suffered dozens of seizures a day, of four different varieties. A multipledrug regimen kept his seizures only partially controlled while burdening the preschooler with side effects, including insomnia and attention deficits. At a friend's suggestion, the Naperville, Ill., family contacted Michael Kohrman, MD, director of the Pediatric Epilepsy Center at the University of Chicago Medicine Comer Children's Hospital. Kohrman recommended implantation of a vagus nerve stimulator and had Nathan evaluated for surgery. Pediatric neurosurgeon Leila Khorasani, MD, implanted the VNS at the beginning of April 2011, and by the end of the month Nathan was seizure free. The VNS delivers tiny electrical impulses to the brain via the vagus nerve every 5 minutes. In addition, the Kalinas also have a special magnet to induce extra electrical impulses to stop a seizure. Nathan still takes antiseizure drugs, but the Kalinas are cautiously starting to wean him off some of them. "He's completely recovered and suffered no long-term damage," Megan says. "His milestones have caught up, he's growing like a weed, and we can breathe again." Kohrman has been able to help many children who have tried two or more drugs and haven't achieved seizure control. He estimates that 5,000 children in the Chicago area could benefit from surgical treatment for their seizures, but only about 100 per year receive such treatment. "Ultimately our goal is no seizures and no side effects," Kohrman said. The University of Chicago Medicine offers advanced, seamless epilepsy care for patients of all ages. The pediatric and adult epilepsy programs are accredited as Level 4 epilepsy centers — the highest rating available — from the National Association of Epilepsy Centers. Our multispecialty team excels at providing
patients with a definitive diagnosis and uses sophisticated evaluation techniques to optimize both surgery and drug treatments. Adult and pediatric epilepsy care is offered on the main University of Chicago Medicine campus in Hyde Park. In addition, pediatric epilepsy experts see patients at offices in Elmhurst, Ill., Hinsdale, Ill., Naperville, Ill., Palos Heights, Ill., and Merrillville, Ind. While Nathan's response to VNS is atypically good, Kohrman says the University of Chicago Medicine has better than average success rates with this procedure and others because of its expertise in identifying patients likely to benefit from a given treatment strategy. The vast majority of the program's surgical patients see their seizure activity drop at least 60 to 75 percent, said David M. Frim, MD, PhD, chief of neurosurgery. Frim, who treats children and adults, says the University of Chicago Medicine epilepsy program's strengths include: Teamwork. "We are a truly integrated program, between adult and pediatric epileptologists, neurosurgeons, neuroradiologists, neurophysiologists, and nurse specialists. The best part of the program is the interdisciplinary conference where we are all there to think about the best way to treat each individual patient," Frim said. The team keeps in close communication with referring physicians. Experience. "We see so many epilepsy patients that our system is continuously running, and we don't have big breaks." This provides the opportunity for these experts to learn from the outcomes of a larger group of patients. Resources. Dedicated inpatient units, including an adult neuro-ICU, a specialized adult neuro unit with six beds wired for advanced monitoring, a distinct area of the pediatric ICU specifically equipped for epilepsy monitoring and eight beds in the pediatric epilepsy center's long-term monitoring unit staffed by specially trained nurses. uchicagokidshospital.org/specialties/epilepsy
Sharon O'Keefe, left, and Susan Axelrod
The The quest quest for for aa cure cure Susan Susan Axelrod Axelrod co-founded co-founded Citizens Citizens United United for for Research Research inin Epilepsy Epilepsy (CURE) (CURE) inin 1998 1998 out out of of frustration frustration after after not not being being able able to to find find successful successful therapy therapy for for her her daughter daughter Lauren's Lauren's seizures. seizures. The The Axelrods Axelrods (Susan's (Susan's husband, husband, David, David, isis an an advisor advisor to to President President Barack Barack Obama) Obama) tried tried countless countless drugs, drugs, special special diets diets and and surgery, surgery, with with no no effect. effect. Lauren, Lauren, now now inin her her 30s, 30s, suffered suffered brain brain damage. damage. But But she she has has been been seizure seizure free free since since 2000, 2000, thanks thanks to to aa single single drug drug that that proved proved effective effective for for her. her. Since Since its its inception, inception, CURE CURE has has raised raised more more than than $18 million for epilepsy research and $18 million for epilepsy research and awareness. awareness. University of Chicago Medical Center University of Chicago Centerto the President Sharon O'KeefeMedical was named President Sharon O'Keefeboard was in named the national organization's May. "Itohave national May. "I have seen howorganization's epilepsy can board disruptinthe lives and plans seen how epilepsy canfamilies," disrupt the and plans of patients and their saidlives O'Keefe, the of patients their families," O'Keefe, mother of aand child with epilepsy.said "I also havethe seen mother of a child withtoward epilepsy. "I also have seen remarkable progress understanding this remarkable progress towardresearch. understanding disease through innovative I look this disease innovative research.speed I lookup the forwardthrough to this new role in helping forward to this new role in helping speed upand, the pace of progress in understanding, treating pace of progress we hope, curing in thisunderstanding, disorder." treating and, we curing thisvisit disorder." For hope, more information, cureepilepsy.org.
Mapping the brain EEG monitoring, MRI scans and even PET scans can prove inadequate for identifying the exact location of an epileptic focus. But the University of Chicago Medicine is a leader in the nation in its ability to analyze data from multiple imaging scans and other testing to produce a highly detailed, three-dimensional image of the brain and its electrical activity. These images help the multispecialty epilepsy team determine whether the patient is a candidate for potentially curative epilepsy surgery. The images also can precisely guide surgeons to the abnormal area of the brain that is causing the seizures or allow more targeted investigations that improve the accuracy of the seizure surgery, allowing it to be less invasive. "We can concentrate on finding the safest and least traumatic way to remove the seizurecausing area," said David M. Frim, MD, PhD, chief of neurosurgery, "because we're so sure that we are operating on the correct tissue."
Innovative treatment for advanced head and neck cancer Multispecialty team successfully treats stage 4 cancer without radical surgery
iping the sweat off his face after a 10-mile run in 2009, Craig Martin discovered the lump under his left jaw. An ENT issued a grim diagnosis: the 46-year-old arborist from Libertyville, Ill., had stage 4 tonsil cancer. After extensive research, Martin chose the University of Chicago Medicine for its vast experience treating advanced head and neck cancers and excellent survival rates. "There are many subtleties in treating the various types of head and neck cancers," said Daniel J. Haraf, MD, medical director of radiation oncology. The head and neck cancer team — medical and radiation oncologists, and head and neck surgeons — focuses exclusively on these difficult malignancies. Kerstin Stenson, MD, and The multidisDaniel J. Haraf, MD ciplinary team pioneered integrated chemoradiotherapy that effectively treats 80 percent of stage 4 head and neck cancers without ablative surgery. "Our highly coordinated multispecialty care focuses on organ preservation. Surgery is used for salvage in the uncommon scenario of treatment failure," said Everett E. Vokes, MD, physician-in-chief at the University of Chicago Medicine. Martin's treatment consisted of weekly chemotherapy for 15 weeks and 50 Glenn Bovard treatments of intensity-modulated radiation therapy (IMRT). Haraf was one of the first physicians in Chicago to offer IMRT, which shapes the radiation field to INSPIRED
Craig Martin of Libertyville, Ill., is back to serious running after treatment for advanced tonsil cancer at the University of Chicago Medicine.
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the contour of tumors. "With IMRT, we can better target tumors with higher doses of radiation while sparing critical structures and normal tissue in the area, such as salivary glands or the spinal cord," he said. For oral cavity tumors or small, early-stage lesions, surgery is often preferable to radiation. "For the newly diagnosed patient, we have every tool to remove the cancer while preserving the function of their organs. Endoscopic laser surgery, new reconstructive techniques and robotic surgery allow us to remove tumors through the mouth instead of opening up the neck," said Kerstin Stenson, MD, who directs the medical center's head and neck surgery program. The surgical team also treats patients whose recurrent cancers may have been deemed unresectable by other surgeons and those with complex wounds resulting from chemoradiation, such as osteoradionecrosis. "Patients who typically haven't been given much hope are referred here," Stenson said. "Our team is able to give hope for cancer control, pain and wound management and restoration of function." One of those options is a second round of full-dose radiation therapy — a treatment few cancer centers offer. Haraf is considered one of the world's leading authorities on reirradiation. Martin, whose cancer went into remission last fall, is back to serious running and biking. "I have no limitations, and I feel great today," Martin said. "But even when I was at my sickest, the team at the University of Chicago made me feel strong mentally because of their confidence that my treatment would work." uchospitals.edu/specialties/cancer/head-neck
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World-class care for a rare childhood cancer
Maggie Leander
Neuroblastoma specialists offer expertise, access to new therapies Neuroblastoma is the most common cancer in infants, but it's still so rare that even many pediatric oncologists see few cases. Approximately 700 children are diagnosed with the disease in the United States each year. The neuroblastoma program at the University of Chicago Medicine Comer Children's Hospital draws families from across the country and offers a full range of treatment options, including new therapies not widely available elsewhere. "Sometimes standard treatment approaches don't work," said pediatric oncologist Susan L. Cohn, MD. "An experienced medical team is needed to ensure that each child receives the proper
treatment. It is also critical to recognize when the therapy is too toxic or not effective so that alternative treatment strategies can be initiated." Cohn, director of clinical sciences in the Department of Pediatrics at the University of Chicago Medicine, is recognized as one of the nation's top authorities on neuroblastoma. She is among a handful of physicians in the country conducting Phase 1 clinical trials of promising new drug therapies for children with aggressive, difficult-to-treat forms of the disease. Cohn works with a multidisciplinary team that includes surgeons, radiation therapists, pathologists, radiologists and
clinical and basic science researchers. Luke and Breanna Leander made the trip from Cambridge, Ill., near the Iowa border to seek Cohn's expertise to treat their daughter Maggie. Their baby, who had been diagnosed when she was only 10 days old, had a low-risk form of the disease. But the cantaloupe-size tumor in the baby's belly was causing her breathing to become labored and rapid. Maggie spent four weeks in the hospital getting inpatient chemotherapy. Today she is a healthy 2-year-old. Cohn's research focuses on tumor genetics and the development of targeted therapies. "The goal now is to better understand the biologic factors that induce aggressive tumor growth and develop treatments that will block these growth-promoting molecules," she said. University of Chicago Medicine Comer Children's Hospital physicians have leadership roles in the Children's Oncology Group (COG), the New Approaches to Neuroblastoma Therapy (NANT) consortium and the Advances in Neuroblastoma Research Association. Cohn also is co-chair of the International Neuroblastoma Risk Group (INRG) Task Force, which since 2005 has compiled data on neuroblastoma patients from around the world. These data have led to new informaSusan L. Cohn, MD tion about prognostic factors and tumor behavior. A recent COG clinical trial has demonstrated that survival for patients with high-risk neuroblastoma can be improved by 20 percent with the addition of immunotherapy. "However, less than 40 percent of high-risk patients are cured with current treatment approaches," Cohn said. "We must continue to conduct research to ensure that we find a cure for all children with neuroblastoma." uchicagokidshospital.org/specialties/cancer/ neuroblastoma
organs, Becker encourages early referral for transplant evaluation. "Most patients who come to us are already on dialysis but can and should get listed (in the national organ recipient database) before starting, if possible," she said. "Once their creatinine clearance is less than 20, they can start gathering time on the list. We now know there is a clear survival benefit to pre-emptive transplant." Interdisciplinary, team-based care is the hallmark of the transplant program at the
"It was vital to be at an institution on the leading edge where they develop the next innovations in transplants." MaryLou Krippner of Lisle, Ill., who received a kidney transplant at the University of Chicago Medicine in August 2011
MaryLou Krippner and Yolanda T. Becker, MD
At the forefront of transplant care Kidney and kidney-pancreas program delivers leading-edge, personalized care
atients with severe kidney failure eventually find themselves with limited options: peritoneal dialysis, hemodialysis, or kidney or kidney-pancreas transplant. Of these transplant options, kidneyonly transplant may be what comes to mind first, especially for patients with type 2 diabetes or who may obtain a living kidney donor match. But Yolanda T. Becker, MD, director of the University of Chicago Medicine kidney and pancreas transplant program, encourages colleagues to cast a wide net when considering the patients, typically younger and with type 1 diabetes, who might benefit from a kidney-pancreas transplant. "Our kidney-pancreas program is growing, as referring physicians realize its enormous benefits," she said. "It's true that patients will still need medication after transplant, though they INSPIRED
will be able to discontinue insulin. Transplant also helps slow complications of diabetes, including neuropathy and retinopathy." The University of Chicago Medicine was one of the first medical centers to offer kidney-pancreas transplants, which typically are covered by Medicare and major insurance providers. "The kidney-pancreas transplant program is one of the centerpieces of our multi-organ transplant program, where the University of Chicago Medicine is and remains a leader," said J. Michael Millis, MD, chief of transplant surgery. "That's important because patients — especially those with diabetes — may need to consider many options, including kidney-pancreas and even heart-liverkidney." Given the potential wait for donor
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University of Chicago Medicine. Each patient is assigned to a personal transplant coordinator throughout the initial evaluation and the typical years-long wait for a donor organ. "We create a personalized schedule for updating each patient's testing and visits so when the organ becomes available, we can move immediately," said Katrina Harmon, RN, MSN, CCTC, pre-transplant nurse coordinator. This individualized approach continues after transplant. "We tailor the patients' care to their needs and preferences," Harmon said. MaryLou Krippner of Lisle, Ill., received a kidney transplant in August 2011 after a five-year wait. "The posttransplant team has been very accommodating about working with me to get my labs done locally in the suburbs as soon as possible," she said. Once the initial recovery period is over, many patients experience a profound improvement in quality of life. Tim Kramer, a kidney-pancreas transplant recipient from Lakewood, Ohio, had been waiting for donor organs for three years and was on dialysis for five months. The 38-year-old social worker has type 1 diabetes. Since receiving his transplant, Kramer has run a 10K and a half-marathon. "Running again has been the best gift of all," he said. uchospitals.edu/specialties/transplant/kidney.html
Eyeing the future
Seenu M. Hariprasad, MD
Grateful patients donate to support research to help solve the challenge of age-related vision loss
After two failed eye surgeries, Richard Hill of South Bend, Ind., was getting desperate as the vision in his right eye continued to deteriorate from retinal detachment. That changed the moment he met Seenu M. Hariprasad, MD, a vitreoretinal specialist and director of clinical research in ophthalmology and
visual science at the University of Chicago Medicine. "He touched my arm, looked at me and said, 'I can fix this,'" Hill recalled. Hariprasad, named one of the top ophthalmologists in the country by Becker's Healthcare, is known for his innovative approaches to surgery,
News from the University of Chicago Medicine and Biological Sciences
Inspired …to discover,
to teach and
to give back Richard L. Schilsky, MD, professor of medicine and hematology/oncology section chief, was named a Fellow of the American Society of Clinical Oncology (ASCO) for his volunteer service, dedication and efforts on behalf of the specialty of oncology and patients. Peter Angelos, MD, PhD, the Linda Kohler Anderson Professor of Surgery, chief of endocrine surgery and associate director of the MacLean Center for Clinical Medical Ethics, holds the nation's first endowed chair in surgical ethics.
Jeffrey B. Matthews, MD, the Dallas B. Phemister Professor of Surgery and chair of surgery, has been elected president of the Society for Surgery of the Alimentary Tract (SSAT). Anne R. McCall, MD, has been named medical director for radiation oncology at the University of Chicago Medicine Comprehensive Cancer Center at Silver Cross Hospital. McCall, assistant professor of radiation and cellular oncology, has a background in both academic and community hospital settings.
including a sutureless microincisional vitrectomy technique that reduces both operative time and postoperative pain. "It's no secret we deal with patients who have complex issues," says Hariprasad, who specializes in diabetic eye diseases, intraocular infections and age-related macular degeneration. Hariprasad also is director of a highly specialized fellowship program in diseases and surgery of the retina, macula and vitreous. To date, grateful patients have donated $56,000 to help train future retina specialists. "By the year 2020, the number of patients who go blind each year will double due to age-related diseases; there are not enough vitreoretinal specialists to treat them," he says. "People who donate to us are really training the future of this field." Hill, an attorney with a passion for boating, is once again able to function without limitations. "I have a great deal of respect and admiration for Dr. Hariprasad, not only for his surgical proficiency and skill in training fellows, but also for the caring approach he extends to his patients," Hill said. "I'm looking forward to a great sailing season on Lake Michigan. I really missed that last year." For more information or to support the research of Seenu M. Hariprasad, MD, please contact Alicia Kearns at email@example.com.
David T. Rubin, MD, professor of medicine and co-director of the Inflammatory Bowel Disease Center, received the Rosenthal Award for Patient Support and Care, a national leadership award from the Crohn's & Colitis Foundation of America. Michael Maitland, MD, PhD, assistant professor of medicine, received the Leon I. Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics. Maitland is assistant director for clinical education in the Center for Personalized Therapeutics. Donations from Jim and Karen Frank and others will endow the Janet Davison Rowley, MD, Professorship in Cancer Research at the University of Chicago Medicine, a named professorship honoring one of the University's most distinguished scientists and alumni. Jim Frank is a University of Chicago Medical Center trustee.
Jill C. Glick, MD, professor of pediatrics and medical director of Child Protective Services, and Mark Myren, PA-C for the cardiac surgery service, are 2012 recipients of Social Work Humanitarian Awards honoring non-social workers who best reflect the values and ethics of the profession and the University of Chicago Medicine. Michelle M. Le Beau, PhD, director of the University of Chicago Medicine Comprehensive Cancer Center, was elected to the board of directors for the American Association for Cancer Research. Le Beau is the Arthur and Marian Edelstein Professor of Medicine. Olufunmilayo I. Olopade, MD, the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics and director of the Cancer Risk Clinic, was appointed by President Barack Obama to the National Cancer Advisory Board.
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text: Has anyone been able to set the tivo stream to port forward in the system information menu? Ive forwarded the ports in my router, but i am not able to enable port forwarding in the Out-of-Home menu. every time i click the check box, the check dissapears. it will not let me select it. anyone else seeing this? thanks.

subset: commoncrawl


text:
Site Navigation
CORRECTION - Supplementary Assessment Report
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text:
How Often Do You Clean Your House?
A Stanley Steemer Cleaning survey shows the average amount of time we spend doing a full cleaning of our homes is about four hours. 9% of those surveyed would rather endure the physical pain of a root canal than do a full cleaning of their home. See how you match up with the survey results:


text:
- Services
- We strive to provide complete care for our patients. Learn more about all the services we provide.
Welcome to Ritz and Johnson
Your Optometrist in Ocala, FL.
Call us at 352-732-7900 today.
Dr. Johnson, Dr. Willeford and Dr. Menjivar and our entire caring, experienced staff welcome you and your family to Ritz and Johnson Fashion Eyecare Center, our full-service vision care provider serving patients throughout Ocala, Silver Springs, Anthony and The Villages. We have been serving the community since the 1970's, and have been at our current location on SE 17th Street since 1986. With three eye doctors on call, we always have an experienced Ocala optometrist ready to help. We can schedule your regular eye exam or contact lens exam when it is convenient for you, and we can take eye emergency calls promptly. Call us immediately if you need assistance: (352) 732-7900
Medical Optometry with Your Ocala Eye Doctor
Keeping your eyes healthy throughout your life depends on scheduling a regular eye exam with an experienced Ocala eye doctor. Here at Ritz and Johnson Fashion Eyecare Center, we provide the latest in high-tech medical optometry so that we can diagnose and treat any eye disease problems quickly and comfortably for everyone in your family.
Comprehensive Eye Exam
Our comprehensive eye exam includes in-depth, high-tech testing of your vision function, eye health and overall eye-function. This enables us to catch eye disease processes early, when they are most easily treated. This includes everything from keratoconus and dry eye to eye infections amblyopia, glaucoma and more. We also have a special contact lens exam.
Pediatric Eye Exams
We are great with children's eye exams! We realize that this can be a stressful thing for our youngest patients, but your Ocala optometrist and our kind staff will make the whole process comfortable while catching and treating any eye problems early for a positive outcome on their learning and development.
Senior Eye Exams
Your Ocala eye doctor is also experienced in diagnosing and treating any eye condition or disease affecting senior citizens. Not only are our optometrists careful to find any local eye disease processes, but can be an important partner with your primary care physician in monitoring other health concerns that affect the eyes.
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For our local athletes, our Ocala optometrists also do a special eye exam to measure visual acuity, tracking and depth perception needed for athletic performance.
Contact Lenses to Designer Frames within Your Budget
Ritz & Johnson Fashion Eyecare Center stands out in the Ocala, Silver Springs, Anthony and The Villages areas because of our huge selection of over 2000 designer frames, a myriad of contact lens styles (even for hard-to-fit patients) with a wide range of prices to fit every budget. Our staff spends all the time necessary to help you find exactly the right designer frames for you, at a price you can feel great about.
Visit Our Ocala Optometrist
Schedule an appointment with us online for anyone in your family, or simply call us at (352) 732-7900 to ask any questions about our services. We look forward to working with you and helping you see all you can see!
The Optometrists at Ritz and Johnson
Dr. Ray Johnson| Dr. Willeford | Dr. Menjivar | Dr. Aida Glatter-Götz
150 SE 17th St., Suite 100
Ocala, FL 34471


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I love budgeting.
Let me count the ways.
My budget set me financially free.
For the rest of my days.
10 Reasons I Love Budgeting
- Reduced stress.
- Clear plan for the future.
- Intentional generosity.
- Focused savings.
- Anticipate future expenses.
- Same page as my bride.
- Allows me to maximize every dollar.
- Funded my dreams.
- Blessing my children.
- I can use a Microsoft Excel spreadsheet.
Do you love budgeting? Why?


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By Vince Font
You can find a good number of cheap Caribbean vacations that'll make you do a double-take of disbelief when you view the final price tag. But with so many resorts to choose from, how do you find the best resort for the money? Minimize your risk: book a package — hotel plus flight — and go with one of these three cheap Caribbean vacation steals.
Sandals Whitehouse European Village & Spa, Montego Bay
If you think Montego Bay is only for gamblers, you've spent too much time in Vegas and not enough time in the Caribbean. Next time you need a vacation, consider heading instead to Jamaica and the Sandals Whitehouse European Village & Spa. Between now and December 26, you can get up to 65% off a 3-night stay plus airfare, bringing the total cost to just over $1000 per person—one of the cheapest Caribbean vacation packages at one of the most luxurious resorts — a darn good deal. Its remote location might be considered a drawback, but that's all depending on how you view it. A 90-minute shuttle ride from Sangster International airport could either give you plenty of time to take in the countryside, or drive you nuts. I opted for enjoying the scenery, which made the eventual arrival at the resort all the more pleasurable. From the expansive white sand beach to poolside swim up bars, to quality restaurants and nighttime entertainment, the only problem here is tearing yourself away at the end of your stay.
Accra Beach Hotel & Resort, Barbados
With Montego Bay out of the way as the first stop for the reformed Vegas visitor intent on broadening their horizons, it's time to explore the Caribbean a bit further—this time to Barbados, where you can book a 4-night stay (yes, including airfare) at the Accra Beach Hotel & Resort on the south coast of Barbados for even less than you'd spend at Montego (at the time of this post, prices were around $850-$900 per person). This time the trip from the airport to the resort won't give you an opportunity to wonder what to do with the money you're saving — Grantley Adams International is only about six miles away. The Deluxe Ocean View Suite offers just what it promises, a great panoramic view of the Caribbean Sea, and comes with a jacuzzi tub and king size bed. If staring atthe sea isn't your thing, you can downgrade to an equally serene pool view. Just a quick stroll from the resort grounds you'll find a boardwalk lined with bars and restaurants or, if you're feeling particularly adventurous you can hop a cab to Champers Restaurant, where the view of the ocean from the dining area is a free bonus. The hotel also offers live music and entertainment, as well as a spa that offers a variety of massages, facials, manicures and pedicures.
Breezes Bahamas
If you've got a taste for maximum time at minimum cost, you can find Caribbean vacation packages to the Bahamasthat'll offer both in spades. If you shop smart, you can land a combination airfare and hotel package that'll cost you less than most cheap Caribbean flights—but the operative word is "smart." For both value and quality, check out the Breezes Bahamas all-inclusive resort on Cable Beach in Nassau, where currently every fourth night is free. Activities at the Breezes are aplenty, with waterskiing, windsurfing and sailing in addition to rock climbing and—best of all for the reformed Vegas frequenter itching for the thrill of the bet — gambling casinos which can be accessed by foot down the beach, or by ferry on nearby Paradise Island.
Cheap Caribbean vacations are best had in packages, so be sure to book your flight and your stay at the same time.
Related resources
Vince Font is a freelance writer born in Puerto Rico and currently escaped to Utah. When not dreaming of interstellar travel, he's on the hunt for weird, wacky, and off-the-beaten-track vacation destinations. Next stop: The Lizzie Borden Bed and Breakfast.


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I honestly don't see members of the military willing to unarm fellow Americans. I know if I was giving an order to go house to house and seize weapons I wouldn't be able to do it.
Printable View
Attachment 66202
Read that and understand it.
The Bill of Rights tells the Government what WE THE PEOPLE are free and sets out to list rights that are granted by our creator, not imposed or to be denied by those in power.
You say we are out gunned by the modern army of America, and that it would be a difficult battle at best?
Oh how soon we forget Afghanistan and its freedom fighters who with AK47's and 30 year old armaments, defeated a super power called Russia!
If they can do, I think we would be just fine!
Who says things aren't being planned and that we would be "unorganized" IF a civil war broke out?
O ye of little faith!
The picture does not apply to anything I have said in this thread, in any other thread, or at any time in my life. I never said that the Constitution limits what people can do. However it does outline rights that I wouldn't say were necessarily endowed by our creator. For example, I do not for one second believe that God has granted me the right not to incriminate myself, yet the 5th Amendment does just that.
As far as Afghanistan defeating Russia, it never happened. Just as the United States was not defeated in Vietnam. In each case the superpower lost the stomach for the fight and gave up. Same thing could happen here in the United States. However there were a lot of dead Muslim jihadists by the time the Soviets pulled out.
As far as planned- you may have some plans. If the masses aren't aware they are useless. You and your group can jump up and proclaim that you're the leaders of the struggle. Meanwhile the people in my area will ignore you and end up suspicious of your attempt to put yourself in charge. A group in Florida would ignore someone here if they had been making plans and suddenly said that everyone should follow them. There is no unity and there is no organization. For that to not be true it would have to be known by everyone that will join in the fight.
Thank God I got rid of all my guns yesterday and only come to this board now for entertainment purposes. So, no need to come to my place-- all you'll find in my safe is a slingshot and a box of old rusty 22 shells.
You said "we have further (other) rights as put forth in the Constitution".
The constitution outlines what the government can NOT do, it is not about what WE can do. We have the Bill of Rights, government is LIMITED by the constitution.
Hurricane Katrina Door to Door Firearms Confiscation - YouTube
Charles I've been doing this for far too long. It appears you live in a fantasy world where you and your friends are going to defeat the American military without being harmed in any way and then everyone is going to unite behind you. That being the case, I don't want to be on your side. But let's look a little closer at some of the things you've been talking about.
You said that the Russians were defeated in Afghanistan. That's untrue, but we'll ignore that. The jihadists were receiving funding and arms from the CIA. Since you're looking to go to war with the government, you can rest assured that won't be happening for you. So where are you going to get your mines, bombs, RPGs, Stinger missiles, heavy machine guns, and mortars? Who is going to be flying resupply missions to ensure that you have uninterrupted access to ammunition, food, medicine, and other supplies?
You've talked about your "connections" and how high up in government they are. I personally have contacts at several of the letter agencies, throughout the special operations command, and in the legislative branch of the federal government (and in the last executive branch) and none of them are talking about or concerned with the things you say there is a mass conspiracy to turn against the government about. Some of these people are my best friends, I know what they are and are not worried about. This thread doesn't contain anything that worries any of them. Again, it is very possible that there are elements that are ready to do just as you say. But it isn't nearly as widespread as you assert or it would be more well known.
In the end, I stand by my initial statement. When they come for your guns, you can stand and fight. If you're well equipped and trained you're likely to be able to inflict some heavy damage upon those that are performing the raid, but in the end they will win. You will not have your guns, it is largely up to you whether you are dead or in custody at the conclusion. If enough people follow your example it is likely that the will to perform these raids would erode until it isn't possible to field teams to do it, so the war is a victory. But the individual battles will see many, many losses. You don't suddenly become Rambo because you envision yourself as one with our tricorn wearing ancestors. We can huff and puff and try to talk our way out of corners, but in the end these are the simple facts. The question isn't how it turns out for those that fight. The question is how many are willing to pay the price for fighting. I'm not optimistic that the number of people that are truly ready to fight and die for their beliefs is all that high.
I completely agree with you. Some of these people are delusional to think that they stand a chance to fighting off a trained military or police force that is there with the purpose to take your guns. The military today has done nothing but fight an asymmetrical warfare for the last 11 years and has become pretty good at fighting an unknown enemy. To believe one lone ranger with maybe an AR-15 and a few pistols is going to successfully going to stand and fight is doing nothing but dying for what he believes in. In my honest opinion the best thing everybody can do is aggressively fight tooth and nail against new gun rules and make our voice heard. The worst thing we can do is just sit back and say it isn't going to happen and do nothing.
It is fine to sit here and think that you can single handily fight off the "bad guys" if that makes you feel better but to actually think that is a viable plan is insane.
So after the government comes and relieves me of my arms, can I file a claim with my insurance agent for all my stolen firearms? Just sayin'
Let's see: I'm a young twenty-year-old Marine, soldier, sailor... who has been well indoctrinated to protect my homeland from "the enemy". I've been deployed to Iraq, then Afghanistan, and now my superiors are telling me that the enemy is at home, and that I'll now be deployed against those "evil " ones who defy the current regime. Those would be my mom, my dad, sisters, brothers, grandparents, aunts, uncles—all those near and dear to me, those people I've been told that I and my buddies have been facing death to protect. I'm not stupid!; I know the regime is a pack of liars and weenies who are cutting costs that are meant to keep me alive; I'm sick to death of being encumbered by "rules of engagement" which forbid me firing on some rag-head who is burying an IED outside my perimeter. Now, these same idiots are sending me to the United States to possibly have to fire on my own people? Although I'm sure there would be those who'd have no scruples in the matter, somehow, I believe these would be in the minority. Somehow, I believe there would be a general uprising within our military which would turn to our favor. Back in the late Fifties and Sixties, I was one of the most gung-ho, bad-arsed Marines in the Corps but, I guarantee you, had a Gunny, Top, lieutenant, captain... general given me the order to fire on an American household, there would have been a dead Gunny, Top, lieutenant, captain... general... and likely a dead sergeant, but there are times when a man must make an ethical decision based on his own system of ethics. So be it.
By the way, Echo_Four, I actually understand what you say, and agree with most of it. I'm not completely unaware of the ramifications of my own actions, and I don't intend to be standing stupidly at my door defying a SWAT team with my 1911 in hand should such a situation come to pass. I'm not charging a machine-gun-nest single-handedly with my trusty M-1. I intend to keep my finger well on the political-pulse, and should even the approach of such actions be suspected, I already have plans in place to become very scarce until the chaos breeds organization. Sometimes it's best to run away, to live and fight another day. However, if caught by surprise, I will stand, if for no other reason than that my violent demise may instil passion in others.
I am a firm believer that—and I paraphrase—Anyone who is willing to give up his freedom for protection, deserves neither.
When (not if) it comes to pass, I would hope, and expect States like Arizona and TEXAS to stand firm, and tell the muslam-in-chief to go f himself. I'd much rather see a civil war, than lay down and become another Poland or Austria. Collectively it could be possible - individually - not a reasonable expectation.
I think we can agree to disagree on who will do what and who will cower in fear of the government.
As for the "Internet commandos" comment, speak for yourself. I am a very capable and trained individual who knows his own limitations. I think anyone who makes the above comment is sadly lacking in intelligence and in need of a long time out.
It's very easy to post remarks about someone when you know nothing about the person you insult.
So, do what you feel is your best option and pray that they don't knock on your door. If they do, give them your guns and call it a day. You can't fight the military so why bother, right?
I am not one to take advice from the law enforcement or military community that I am not personally involved with. I know the score and I know where I stand. Your mileage may vary based on numerous factors but please, just because you don't know me, don't discount my abilities or connections.
I am not trying to "run the show" and I personally don't give a crap if you die on your feet or if you lay down your arms and die on your knees. I know what I will do and how I will go about it so no need to worry about it.
I'll be with the people who chose to stand and fight. You know, the "ones who you don't think are organized because you haven't heard about it".
I would double check my intel because it appears to be lacking.


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Parallax View(2000)
A Novella by Keith Brooke and Eric Brown
Parallax View showcases the previously unpublished Novella 'In Transit', set in a future war-torn universe in which human expansion has come up against the implacable Kryte. Xeno-psychologist Abbott finds himself the guardian of a deadly Kryte on a mission to study it on his return to Earth. When the crash-land on the fortress planet of St Jerome, the Kryte prisoner turns the tables and takes Abbott into terrible custody. What follows is a terrifying journey across a hellish landscape towards a finale that might change the destiny of the Kryte and humanity, forever... Plus six other stories that examine the interface between human and alien - a parallax view from two of Britaine fiction writers. "Individually, Keith Brooke and Eric Brown purvey SF of the highest order: their stories have epic scope and a huge heart. The fusion of their talents is a sublime alchemy, a seamless pageant of humanity and wonder, eloquently expressed." James Lovegrove "These are stories given to us by writers who are immersed in humanity, and yet have the strength and the clarity of vision to see beyond our current horizon. These are mature stories, tales of love and loss, of pleasure and pain." Stephen Baxter "Brooke and Brown"s work has a real sweep to it, and if you're looking to recapture the sadly clichéd sensation of a sense of wonder, this collection will not disappoint." Liz Williams
Similar Books by other authors...
Used availability for Eric Brown's Parallax View
See all available used copies of this book at Abebooks UK or Abebooks US
Hardback Editions
2000 : UK Hardback
|Title: Parallax view
Author(s): Keith Brooke, Eric Brown
ISBN: 1-902309-12-X / 978-1-902309-12-5 (UK edition)
Publisher: Sarob Science Fiction & Fantasy
Availability: Amazon Amazon UK
Paperback Editions
February 2013 : USA Paperback
|Title: Parallax View
Author(s): Keith Brooke, Eric Brown
ISBN: 1-4810-0905-2 / 978-1-4810-0905-8 (USA edition)
Publisher: CreateSpace Independent Publishing Platform
Availability: Amazon Amazon UK Amazon CA
March 2007 : UK Paperback
|Title: Parallax View
Author(s): Keith Brooke, Eric Brown
ISBN: 1-904853-42-0 / 978-1-904853-42-8 (UK edition)
Publisher: Immanion Press
Availability: Amazon Amazon UK Amazon CA
Kindle Editions
December 2013 : USA, Canada, UK Kindle edition
|Title: Parallax View
Author(s): Keith Brooke, Eric Brown
Publisher: infinity plus
Availability: Amazon Amazon UK Amazon CA
Genre Pages


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Browse Recipes By Products:
Pork Fried Rice
2 tablespoons peanut oil
½ pound lean pork, cut in thin strips
½ teaspoon sugar
½ teaspoon salt
½ cup thinly sliced green onions including tops
½ cup thinly sliced celery
2 cups cold cooked rice
1 cup fresh bean sprouts
3 tablespoons soy sauce
3 eggs, lightly beaten
- Heat oil in uncovered wok at 350°F.
- Add next 3 ingredients; stir-fry 2 to 3 minutes.
- Add green onions and celery; stir-fry 1 minute.
- Add rice and bean sprouts; stir-fry 30 seconds.
- Add soy sauce; stir to mix. make well in center of rice; pour in beaten eggs; allow to set; scramble with spatula; stir into rice. Serve immediately.
Makes 4 servings.


text:
|Patriots Look Poised For Another Super Bowl Run
|Bruins Trade For Drew Stafford
|Black and Gold Bruins Turn Yellow On Parade Day
|Inconsistency Will Continue For Bruins Unless A Change Is Made
The TD Garden will host a Winter Classic preview this evening, as the Philadelphia Flyers (14-15-1) come to the Hub for a matchup with the Bruins (16-9-6).
Boston is coming off a disappointing 3-2 overtime loss at the hands of the New York Islanders, a team the B's just can't seem to figure out this year. Despite the loss, Boston still is on an impressive 8-1-2 streak in their last 11 games.
Heading in the opposite direction are the Flyers, who are 2-8-0 in their last 10, and 1-4-0 since switching to new head coach Peter Laviolette. After Tuesday's big 6-2 win over the Islanders, Philly has dropped their last two matchups, a 2-0 shutout to Ottawa and a 4-1 loss in New Jersey.
Here now, a closer look at tonight's skate at the Garden…
Tags: Boston Bruins, Jeff Carter, Peter Laviolette, Philadelphia Flyers, Simon Gagne, Tim Thomas


text:
Related Publications
- Related by Publisher
- Related by Topic
Related Links
Has the Clock Struck Midnight?
By Adam Rubin
Jewish Family & Life (JFL Media), May 2004
Topic: Arab-Israeli Relations, Statehood, Israeli-Arab Relations, Israeli Settlements, Peace
Name of Publication: Sh'ma: A Journal of Jewish Ideas
Editor: Berrin, Susan
Volume/Issue: Vol.34/no.611
Page Number(s): 9-10
Genre: Article
Coverage: Israel
Language: English
Copyright Holder: Publisher
Copyright Information: Download for personal use, freely distribute link
Bibliographic Information:
Rubin, Adam. Has the Clock Struck Midnight?. Sh'ma: A Journal of Jewish Ideas. Jewish Family & Life (JFL Media). May 2004: 9-10. http://www.bjpa.org/Publications/details.cfm?PublicationID=6711
» View Publication
(PDF, 82 Kb)


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Bibliographic Details
Title: THE ITALIANS OF TO-DAY
Publisher: Leipzig, Bernhard Tauchnitz
Publication Date: 1912
Binding: Full-Leather
Book Condition: Good
Dust Jacket Condition: No Jacket
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This example-driven book offers a thorough introduction to Java's APIs for XML Web Services (JAX-WS) and RESTful Web Services (JAX-RS).
Java Web Services: Up and Running takes a clear, pragmatic approach to these technologies by providing a mix of architectural overview, complete working code examples, and short yet precise instructions for compiling, deploying, and executing an application. You'll learn how to write web services from scratch and integrate existing services into your Java applications. With Java Web Services: Up and Running, you will:
Ideal for students as well as experienced programmers, Java Web Services: Up and Running is the concise guide you need to start working with these technologies right away.
Martin Kalin has a Ph.D. from Northwestern University and is a professor in the College of Computing and Digital Media at DePaul University. He has co-written a series of books on C and C++ and written a book on Java for programmers. He enjoys commercial programming and has co-developed large distributed systems in process scheduling and product configuration.
View Martin Kalin's full profile page.
The animal on the cover of Java Web Services: Up and Running is a great cormorant (Phalacrocorax carbo). This bird is a common member of the Phalacrocoracidae family, which consists of about 40 species of cormorants and shags--large seabirds with hooked bills, colored throats, and stiff tail feathers. The name "cormorant" is derived from the Latin corvus marinus, or sea raven, because of its black plumage. An adult cormorant is about 30 inches long and has a wingspan of 60 inches. It has a long neck, a yellow throat, and a white chin patch. The cormorant has a distinctive way of spreading its wings as it perches, which many naturalists believe is a way of drying its feathers, although this explanation is disputed. The cormorant lives mainly near Atlantic waters, on western European and eastern North American coasts, and particularly on the Canadian maritime provinces. It breeds on cliffs or in trees, building nests out of twigs and seaweed. The cormorant is an excellent fisher, able to dive to great depths. In China and Japan, among other places, fishermen have trained this bird using a centuries-old method, in which they tie cords around the throats of the birds--to prevent them from swallowing--and send them out from boats. The cormorants then catch fish in theirmouths, return to the boats, and the fishermen retrieve their catch. Alhough once a successful industry, today cormorant fishing is primarily used for tourism. The cover image is from Cassell's Popular Natural History, Vol. III: Birds. The cover font is Adobe ITC Garamond. The text font is Linotype Birka; the heading font is Adobe Myriad Condensed; and the code font is LucasFont's TheSansMonoCondensed.
(based on 6 reviews)
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By Tumble weed
from NY
About Me Designer, Developer
Comments about oreilly Java Web Services: Up and Running:
The book skims over a number of important topics in a haphazard manner, each successive chapter having little to do with the next. The coding convention and formatting in the book is just torture on the eyes. Can't imagine why a java book will have a method "get_trust_mgr()","respond_to_client()" or variables named "pause_lock".
Bottom Line No, I would not recommend this to a friend
Was this review helpful? Yes / No
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Any one should read this book!
By El Japanese
from Dublin, Tallaght
About Me Developer
This is a GREAT GREAT book and I would advise any new to web services to read it first, it is a very good book to get up and running with web services, on top the author is quick to reply to any question.Great reading!
Bottom Line Yes, I would recommend this to a friend
So far, one of the best I have read.
By javaHobbit
from Miami, FL
The organized and concise manner of his approach is great. Whats better is the "sticking to the cli" to show the code examples. Cant tell you all how many times I have wished authors could just stick to vi and javac instead of IDE's to get their points across! Thanks Martin.
(7 of 7 customers found this review helpful)
Needs a support forum.
By karlkras
from Portland, OR
I picked this up on highly rated reviews from various sources, and from first glance I certainly agree. Martin Kalin is very good at presenting the material. However, as with all things in our technical environment it doesn't take long for the printed word to become out of date very quickly. Within the first two chapters an example is provided that uses Amazon's ECommerce site for generating Web service clients. Problem is, Amazon added another layer of security API since this books release (less then 9 months ago) so running the code as provided fails with a non-descript http error.After hunting around in Amazon's developer forums I found the change and the recommended fix, but now there doesn't seem to any resource available through O'Reilly (or otherwise) for posting this information to others who might be interested in using this book. I'd be willing to do this myself if such a forum were available but I believe this would have to be perpetrated by the author and/or O'Reilly publishing directly.Great book otherwise, but it could be better by offering a forum when matters such as this (which is inevitable) come up.
Very good introduction
By Christian the designer
from Tübingen
SOA is quite large to study before one gets a right feeling to programm something. That book shows elegantly the ins-and-outs of the thematic, using the Java API to perform simple but effective examples. At the end of the book you will be well prepared to study in detail the different parts of that service world.
(1 of 1 customers found this review helpful)
Easy to understand
By Wayne B
from Undisclosed
The book was easier for me to understand than many other books styles I have read. I always respect authors who are willing to have an errata page. This is a big help as all books have errors.
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(707) 827-7019(800) 889-8969
All trademarks and registered trademarks appearing on oreilly.com are the property of their respective owners.


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Eastern Henrico FISH Provides Assistance
By Amy David, Special to the Henrico Citizen 12/19/10
Eastern Henrico FISH depends on the help of local churches and charitable organizations to get members in the community back on their feet.
The non-profit serves Henrico residents east and south of Mechanicsville Turnpike including Highland Springs, Varina, and Sandston providing clothes, food, and financial assistance for people with short term emergencies.
"We strive for FISH's presence to help strengthen Eastern Henrico through the organizations and community that supports us," said Vickie Martin, director of FISH.
Martin has been with FISH since 2002 and got involved with the organization through her church, New Bridge Baptist, and has worked as a volunteer and staff member before becoming director.
FISH, which is a nationwide organization, has been in Metro Richmond for 38 years and since 2001 has served clients and donors out of Village Presbyterian Church with a clothes closet, food pantry, information and referral services.
"We moved to the church to be more accessible to clients and to make it easier for donors to drop things off," said Martin.
The organization helps victims in all kinds of situations that have put them at a disadvantage. FISH covers portions of rent, a mortgage, car repair, or utilities for those that qualify.
FISH has established criteria to help the people in the community who are desperately in need of financial aid or other items and takes time to consider circumstances in each household. Last year, it served 400 households, or about 1,100 individuals.
"We look at what the need is, we see them through that emergency, and are there to help them get through that bump in the road," said Martin.
All of the items such as clothes and food are donated by the community or from members of the 26 churches that are involved with FISH. The group partners with these churches, civic groups, businesses, social services and other government agencies and non-profits to better serve their clients.
"We rely on churches in the community for support," said Martin.
Fundraisers are held by the non-profit to spread awareness and help to aid their mission. An annual benefit concert is held to bring everyone involved in the organization together and take up donations. It's usually the organization's largest event and is held at different venues each year. The most recent concert was held at Sandston Baptist Church.
Eastern Henrico FISH has an average of 50 volunteers, with several coming in each week to assist families and individuals over the phone and work in the clothes closet and food pantry rooms. In 2009, volunteers gave 3,000 hours of their to help clients of FISH.
"Without the support of our volunteers we couldn't maintain," said Martin.
Eutanaha Fluker has volunteered for FISH for over 20 years and has seen the positive effect the organization has on the community.
"FISH does a good job of determining what a person's real needs are and referring them to churches," said Fluker. Like Martin, Fluker is a member of New Bridge Baptist and got involved after word spread about the growing needs of the non-profit.
"It's really important for churches to work together to do what we do for FISH," Fluker said.
Fluker has served as a church representative for the group in the past, worked the phone taking calls from clients and spent hours in the food pantry and clothes closet.
Around this time of year, FISH receives a good amount of food donations for its food pantry but is in serious need of financial donations. It's also seeking other churches that are interested in joining the cause.
"We're always looking to add churches to support our mission," said Martin.
FISH is available to people in the Eastern Henrico area Monday- Friday from 8 a.m. - 2 p.m. Families or individuals needing assistance from FISH, or people who wish to make a contribution, can reach the organization at 222-5564.
James River Juvenile Detention Center to graduate its largest class
Citizen Staff Reports 06/25/2017 General NewsGovernment
James River Juvenile Detention Center will celebrate its largest class of high school graduates June 27, as 13 residents receive their high school diploma or GED certificate.
The ceremony will be held at 10 a.m. at the detention center, 3650 Beaumont Road in Powhatan County. The graduates will mark their academic milestone by walking across a stage in a cap and gown before an audience of family members. A reception will follow. > Read more.
The ceremony will be held at 10 a.m. at the detention center, 3650 Beaumont Road in Powhatan County. The graduates will mark their academic milestone by walking across a stage in a cap and gown before an audience of family members. A reception will follow. > Read more.
Henrico School Board selects redistricting Option E
Citizen Staff Reports 06/23/2017 EducationGeneral News
JUNE 23, 10:30 A.M. – The Henrico County School Board Thursday concluded its latest redistricting process by selecting a plan for middle school redistricting that will impact a number of students in the western and northern parts of the county, as well as a few in Eastern Henrico.
The process sought to reduce overcrowding at Hungary Creek Middle School, create room at Wilder Middle School for a gifted academy and address the poverty level disparity among some middle schools. It will impact about 775 students, according to school system officials. > Read more.
'Senior Cool Care' program to help older adults in Metro Richmond
Citizen Staff Reports 06/22/2017 FeaturesGeneral News
For the 27th year, Senior Connections, The Capital Area Agency on Aging is helping older adults combat summer heat through a program now called "Senior Cool Care" (formerly the Fan Care program) that provides fan and air conditioning units for eligible senior citizens.
The program is available to low-income older adults age 60 and older who reside in the City of Richmond and the counties of Charles City, Chesterfield, Goochland, Hanover, Henrico, New Kent and Powhatan. > Read more.
Cyclist killed in crash was 52-year-old man
Citizen Staff Reports 06/22/2017 General NewsPublic Safety
Henrico Police have named the victim killed June 21 when the bicycle he was riding collided with a truck on Mechanicsville Turnpike near I-64 in Eastern Henrico.
Fifty-two year-old Ray J. Freeman, of Richmond, died at a local hospital after being struck. The truck that hit him was traveling south on Mechanicsville Turnpike. > Read more.
Fifty-two year-old Ray J. Freeman, of Richmond, died at a local hospital after being struck. The truck that hit him was traveling south on Mechanicsville Turnpike. > Read more.
Henrico man sentenced to 10 years in prison for dealing heroin
Citizen Staff Reports 06/22/2017 General NewsPublic Safety
A Henrico man was sentenced June 20 to 10 years in prison for distribution of heroin.
Arlando Harris, 35, pleaded guilty on Dec. 29, 2016. According to the statement of facts filed with the plea agreement, Henrico Police executed a search warrant at Harris' mother's residence in Henrico on March 16, 2016. > Read more.
Arlando Harris, 35, pleaded guilty on Dec. 29, 2016. According to the statement of facts filed with the plea agreement, Henrico Police executed a search warrant at Harris' mother's residence in Henrico on March 16, 2016. > Read more.
Henrico man sentenced to 10 years in prison for dealing heroin
Glen Allen HS student earns playwriting residency
Missing Eastern Henrico man found dead
Henrico Schools to participate in USDA summer food service
Henrico to offer July 20 class on treating opioid overdoses with naloxone
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Jun. 15, 2017Current edition | Archive
Weekend Top 10
'Taste of Virginia' returning to Innsbrook Pavilion July 1
Restaurant Watch
Weekend Top 10
Yoga center hosting art exhibit
- More Entertainment
Obituary – Hoyle S. "Chick" Walters
Obituary – Janet Sue Vest
Obituary – Barbara Jean (Chilton) Crider
- More Obituaries
Anthem LemonAid registration now open
YMCA to offer free weekend access for teens this summer
Henrico NAACP to host public safety forum June 10
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Growing a grown-up: Part II
How to grow an adult
Make 'em take the pledge: no more snuff boxes!
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Code Lacrosse joins Richmond Strikers
5 Henrico student-athletes win scholarships at awards dinner
RIR to host playoff race in 2018
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|June 2017
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CalendarThe Innsbrook Classic will start at 11:30 a.m. at The Federal Club in Glen Allen. Thirty-six teams will compete with proceeds to benefit St. Joseph's Villa. This year's celebrity golfer is newscaster Greg McQuade from CBS 6 Virginia This Morning. For details, visit http://www.innsbrook.com. Full text


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|"Robert Muir (JIRA)" <j...@apache.org>
|[jira] Updated: (LUCENE-2458) queryparser shouldn't generate phrasequeries based on term count
|Mon, 24 May 2010 19:18:24 GMT
[ https://issues.apache.org/jira/browse/LUCENE-2458?page=com.atlassian.jira.plugin.system.issuetabpanels:all-tabpanel ] Robert Muir updated LUCENE-2458: -------------------------------- Attachment: LUCENE-2458.patch updated patch that cuts over the remaining two qps: the flexible queryparser and precedence queryparser > queryparser shouldn't generate phrasequeries based on term count > ---------------------------------------------------------------- > > Key: LUCENE-2458 > URL: https://issues.apache.org/jira/browse/LUCENE-2458 > Project: Lucene - Java > Issue Type: Bug > Components: QueryParser > Reporter: Robert Muir > Assignee: Robert Muir > Priority: Blocker > Fix For: 3.1, 4.0 > > Attachments: LUCENE-2458.patch, LUCENE-2458.patch, LUCENE-2458.patch > > > The current method in the queryparser to generate phrasequeries is wrong: > The Query Syntax documentation (http://lucene.apache.org/java/3_0_1/queryparsersyntax.html) states: > {noformat} > A Phrase is a group of words surrounded by double quotes such as "hello dolly". > {noformat} > But as we know, this isn't actually true. > Instead the terms are first divided on whitespace, then the analyzer term count is used as some sort of "heuristic" to determine if its a phrase query or not. > This assumption is a disaster for languages that don't use whitespace separation: CJK, compounding European languages like German, Finnish, etc. It also > makes it difficult for people to use n-gram analysis techniques. In these cases you get bad relevance (MAP improves nearly *10x* if you use a PositionFilter at query-time to "turn this off" for chinese). > For even english, this undocumented behavior is bad. Perhaps in some cases its being abused as some heuristic to "second guess" the tokenizer and piece back things it shouldn't have split, but for large collections, doing things like generating phrasequeries because StandardTokenizer split a compound on a dash can cause serious performance problems. Instead people should analyze their text with the appropriate methods, and QueryParser should only generate phrase queries when the syntax asks for one. > The PositionFilter in contrib can be seen as a workaround, but its pretty obscure and people are not familiar with it. The result is we have bad out-of-box behavior for many languages, and bad performance for others on some inputs. > I propose instead that we change the grammar to actually look for double quotes to determine when to generate a phrase query, consistent with the documentation. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online. --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
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Pauline M. Stegenga, 84, of Streetsboro passed away Sunday May 11, 2014. Funeral services will be announced by the Shorts Spicer Crislip Funeral Homes Streetsboro Chapel.
(Shorts Spicer Crislip Funeral Home Streetsboro Chapel 330-626-4966 R-C 5-12-14)
I am so sorry for your loss. My thoughts and prayers are with you and your family.
Love Diane Lexa Vasseur


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Member Since: December 3, 2010
Country: United States
Is there a simple way to find out the correct orientation of the ISP header? I can't see any markings on the board, and the plug on the Sparkfun programmer also does not seem to have markings for correct orientation.
I did determine the orientation from the schematic and a volt meter, but wonder if there isn't a simpler approach? Thanks.
No public wish lists :(


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It's Easter and time for a break. I've been unable to devote as much time to the blog as I would like over the past couple of weeks as the other parts of my job have been clamouring for my time. I'm in the early phases of a really big project that will change the […]
Tag Archives | Holiday
Holiday time again
Holiday Time No1 2009
I know it seems that I'm never in. For my American readers, European companies offer at least 25 day's holiday each year, and my generous employer offers slightly more. You'd take them, wouldn't you?… So I am making a dint in my 2009 allocation.But there'll still be things to see on the blog. I've been […]
Holiday time for Biofuelsimon
I've got two days off this week, tomorrow and Friday. I'll be back hard at it on Monday though. See you then.
Holiday time for me
I'm off on annual leave on 1 August returning to the office on 18 August. I'll be travelling irritatingly slowly up the UK motorway system in an attempt not to have to refill the car any more than I can manage. At £1.18 litre ($8.93/us gal) even with 40 UK miles per gal on a […]
I'm on holiday for a few days
I'll be out of the office for a couple of days back on 29th May. See you then.
DuPont Genencor conference
DuPont and Genencor hosted a conference call this afternoon about the launch of their cellulosic biofuels joint venure DuPont Danisco Cellulosic Ethanol LLC. Aside from the $140m to be invested over three years. Key takeaways for me:1. Chad Holiday, ceo DuPont says the JV does not weaken commitment to biobutanol, or the joint venture with […]
Holdaytime for Biofuelsimon
Dear All, I'm on Holiday or working out of town until 26 February. I'll be back, shoulder to the wheel, nose to the grindstone, foot in the door and shoulders to the yolk on 26th… well that's the plan.
I'm on holiday!
I'll be out of the office on holiday (doesn't my life seem like one long holiday) from Monday 22 October to 26th October). I'll only be thinking about work intermittently (if at all) during that time. So I've left you some things that are good to watch mostly from you tube.
Holiday Time
I am going to be on Holiday from this evening until Monday 13 August when I am planning to be back refreshed and ready to go. Posting will be a bit intermittent, but there should be a couple of items each week.


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- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Militaria & Weapons
- Source: eBay
- Sold Date: Feb 11, 2007
- Channel: Auction House
You are looking at a beautiful 1981 Western USA Bone handle one blade lockback knife - Pattern # S-524. This knife is 3 5/8 inches long (closed). The beautiful brown bone handles have no chips or cracks. The blade has excellent blade snap with no scratches. This knife has a pointer hunting dog etched on the blade. Stamped on the front tang is "Western USA S-524 Pat. 40400181". It also has an "E" which means it was made in 1981. It comes in a cute little imitation leather pouch and the original box with the paper work. Knife, box, pouch and paperwork in perfect conditon. This is a very nice collectible Western USA knife. Will accept paypal or a money order. Buyer to pay $6.00 shipping. Insurance is optional and will cost $1.35 extra for $50.00 insurance. Thanks for looking. NO RESERVE!!!!


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Grumpy Cat Stars in 'Hard To Be a Cat at Christmas' Music Video
Friskies put together a kitty supergroup featuring Grumpy Cat and friends and made this video for a great cause! YOU can help by sharing this video with your friends! For every view of the video (up to 500,000 views) Friskies will donate one can of wet cat food to shelter and rescue organizations across the country!