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Community Education and Workforce Development offers a wide array of online learning options. Online courses are affordable, fun, fast, and convenient. Courses are available 24/7, which provides the busy person the flexibility over when to access course lessons. Online learning options are as follows:
Ed2go.com offers online courses on just about every topic you can imagine. From Creating Web Pages to Accounting Fundamentals, Speed Spanish to Grant Writing, Medical Terminology to Real Estate Investing, and much, much more. For a complete list of courses, visit ed2go's Online Instruction Center.
Ed2go also offers online career training courses . These are career-focused online courses designed to provide you with the skills necessary to acquire professional caliber positions in many in-demand occupations.
Our instructor-facilitated courses are available anytime, anywhere. All you need is a web-enabled computer and a desire to learn skills that will prepare you for a new career or update current skill sets. And even though you don't have to attend class, you won't be on your own. A team of available online professionals, anytime scheduling, and educational textbooks combine to give you a relevant, interactive learning experience.
We offer courses in Healthcare, Business/Legal, Internet/Computer/IT Certification (Microsoft and CompTIA Official Curriculum), Professional/Technical/Design, Construction, and Video Gaming Design and Development. For a complete listing of all titles, please visit our website at careertraining.ed2go/sussexcce/. Financing is available through Ed2go.


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I stated obama can appoint two per term..yes you are<quoted text>
If all 9 died or resigned the president would be within his constitutional duties to nominate 9 more. I give you the relevant portion of the US Constitution. I give you a link to the full constitution completely annotated for your reading pleasure and still you cant grasp the meaning.
Where do you see 2? Article II or Section 2? Wow. Youre amazing.
Why are there nine? Several reasons come to mind. First and odd number may have been chosen to prevent a tie. Second, the more justices there are the less likely a sitting president can achieve undue influence on the court. Since theyre all lifetime appointments one would expect very little change during a sitting presidents two terms.
1789 6
1801 5
1802 6
1807 7
1837 9
1863 10
1866 7
1867 8
1869 9
Congress controls the number of justices. Congress has changed the number to prevent a sitting president to appoint justices, as in the case of Andrew Johnson. Recall Andrew Johnson was impeached.
correct if all died ..however I have a better chance of you being a human before that happens ,
so in a sense you are correct .... bet you and I will never see it
as in every rule there is always an exception...

subset: commoncrawl


text:
Each book provides free YouTube-style demonstration videos that teach and demonstrate all the critical guitar parts – up close and slowed down. Also included is Alfred's exclusive TNT2 Custom Mix software, which provides a professional 6-channel mixer interface to create a play-along mix, loop sections, and even slow down or change keys. The British Invasion edition contains arrangements of the 1964 "British Invasion" music revolution, led by way of the Beatles. Seven pivotal early Beatles songs are included, such as "Do You Want to Know a Secret," "From Me to You," "I Saw Her Standing There," and more. The Led Zeppelin edition includes eight arrangements from the band that forever changed rock and roll. Formed with the goal of fusing very heavy rock and British folk music, the book includes some of the songs the band was best known for, such as "Babe I'm Gonna Leave You," "Black Dog," "Bron-Yr-Aur," "Stairway to Heaven," "Immigrant Song," and more. The Rolling Stones edition provides eight arrangements showcasing Keith Richards' gut-punching guitar riffs, such as "Honky Tonk Women, " "The Last Time," "Jumpin' Jack Flash," "Paint It, Black," "(I Can't Get No) Satisaction," and more.
As part of Alfred's ongoing commitment to improving the environment, these books are printed on 100% recycled paper.
The new Ultimate Easy Play-Along Book & CD sets are now available for $16.99 each at music retail stores and at alfred.com/guitar.


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A defect that is concealed or inactive. Damage from a latent defect is typically
excluded from coverage under all risks property insurance policies. For example,
a home owner discovers that his roof is decaying because the shingles were treated
improperly with fire-retardant chemicals. The cost to replace those shingles
is precluded due to the "latent defect" exclusion. However, if a fire were to
ensue, the exclusion would not prevent coverage for the damage from the fire.
Links for IRMI Online Subscribers Only:


text:
Starbabe Model
Soraja DavisModel Female Fayetteville, North Carolina, US
My Website: https://www.facebook.com/model.sorajadavisMy MM URL: http://www.modelmayhem.com/ModelSorajaDavis
Mayhem # 3040857
About MeMy name is Soraja and I am 20yrs old. I am mixed with Asian and African American. I was born overseas in Europe. I'm completely in love with fashion from all over. I always work hard and do my best and always n time or early for shoots and shows. Even before a shoot or show i do my homework before it, so that I stay on top of my game and everything will go by more smoothly. My overall goal is to land a contract and do high fashion modeling all over the world. That is why i have joined Model Mayhem to get that chance to work with lots of new people and get that exposure I need.
You can book me for paid shoots. The travel and hotels must be paid for.
The hourly rate can be negotiated upon.
I hope to work with everyone soon! Stay blessed!+.*
Cover model for Indulge Fashion Magazine December issue 2012
RAW Artists Holiday Rawk runway show in Raleigh, NC 2012
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Awesome Addition to Old Friends
- By Steve Haskin
With Awesome Gem arriving at his new home at Old Friends April 7 I thought it would be an appropriate time to reprint a column I wrote in 2010 on this old warrior and the person whose life he changed.
With Awesome Gem arriving at his new home at Old Friends April 7 I thought it would be an appropriate time to reprint a column I wrote in 2010 on this old warrior and the person whose life he changed.
West Point Thoroughbreds' multiple graded stakes winner Awesome Gem arrived at his new home April 7 at Old Friends Equine in Georgetown, Ky.
Jim and Mona Hour's Stryker Phd got up in the final stride to put a head in front of G. G. Ryder to win the $100,000 Berkeley Handicap (gr. III) at Golden Gate Fields Nov. 26.
Joe and Helen Barbazon's Pleasant Acres will inaugurate its new stallion facility in Morriston, Fla., with a ribbon-cutting ceremony and gala from 6-10 p.m. (ET) Jan. 16.
Silver Ranch Stable and Wachtel Stable's Poshsky rallied in the stretch and just got up to defeat longshot Pepper Crown in the $100,000 Berkeley Handicap (gr. III) at Golden Gate Fields Nov. 29.
Big Cazanova is 3-for-3 on the old synthetic surface at Del Mar, and now trainer Peter Miller will see if he can carry his affinity for an artificial track to the Nov. 29 Berkeley Handicap (gr. III) at Golden Gate Fields.
Swung six wide into the stretch, lightly regarded Pepper Crown uncoiled a torrid outside rally and won the $100,315 Berkeley Handicap (gr. III) going away as the longest shot in the field Nov. 30 at Golden Gate Fields.
Mona Hour's Longacres Mile (gr. III) winner Stryker Phd heads a group of nine entered for the $100,000 Berkeley Handicap (gr. III) Nov. 30 at Golden Gate Fields.
The fall meeting at Golden Gate Fields opens Oct. 16, and the 36-day season will feature the simulcast of the Breeders' Cup World Championships as well as the 63rd running of the $100,000 Berkeley Handicap (gr. III).
After rallying from fourth to win the San Francisco Mile Stakes (gr. IIIT) April 26, Pepper Crown will try for a second straight graded stakes win at Golden Gate Fields Monday, April 26 in the All American Stakes (gr. III).
Alex Paszkeicz scored a triple when Pepper Crown, the longest shot on the board at 46-1, rallied along the rail to win the $100,315 San Francisco Mile (gr. IIIT) on yielding turf at Golden Gate Fields April 26.
Jerry Hollendorfer has a trio of older runners set to go in the San Franciso Mile (gr. IIIT) April 26, led by Summer Hit, as the Hall of Fame trainer attempts to win Northern California's top grass race for the third time.
Synthetic specialist Summer Hit controlled the pace as the 4-5 favorite and drew off in the stretch for a one-sided victory in the $100,000 Berkeley Handicap (gr. III) Nov. 29 on the Tapeta surface at Golden Gate Fields.
Teaks North, a grade I winner on turf and a stakes winner on dirt, will try a synthetic surface for the first time in his 30-race career when he starts in the $100,000 Berkeley Handicap (gr. III) at Golden Gate on Nov. 29.
Joe and Helen Barbazon announced the arrival of four additional stallions at their newly formed Pleasant Acres Stallions near Morriston, Fl., along with the 2014 stud fees for the roster, which now numbers six.
Trainer Jerry Hollendorfer won the All American Stakes (gr. III) at Golden Gate Fields with Summer Hit about an hour after claiming the Metropolitan Handicap (gr. I) with Sahara Sky.
Hudson Landing, who captured the 2012 All American Stakes (gr. III) by a nose over Control Seeker last fall, will try to repeat for trainer Blaine Wright and owner Jared Chappell at Golden Gate Fields on Memorial Day May 27.
Versatile Hudson Landing, upset winner of last year's San Francisco Mile (gr. IT), is back to defend his title in the $100,000 event against nine opponents April 27 on the turf at Golden Gate Fields.
by Anne Peters
Awesome Again is one of the most consistent sires of high-class runners in North America.
Global Stage and Forest Mouse, the first two finishers in the Veteran Stakes at Zia Park, head the field for the $200,000 Zia Park Distance Championship Dec. 3, the richest Thoroughbred race of the season at Hobbs, N.M.
Hudson Landing needed every inch of the Golden Gate Fields homestretch to nose out Control Seeker in the $100,000 All American Stakes (gr. III) Nov. 23.
Southern California shipper Gladding will attempt to overcome a five-month absence as the favorite for the $100,000 All American Stakes (gr. III) Nov. 23 at Golden Gate Fields.
Grade I winner and multi-millionaire Awesome Gem has been retired from racing. The 9-year-old son of Awesome Again was scheduled to run in the Sept. 23 Ralph M. Hinds Pomona Handicap at Fairplex.
Red-hot Taylor Said, back in action just 13 days after setting a track record at Hastings Racecourse, held off Winning Machine in the final strides Aug. 19 to capture the $200,000 Longacres Miles (gr. III) by a head.
He's the gift that keeps on giving and the equine version of the Energizer Bunny. Making the 52nd start of his career Aug. 19, Awesome Gem steps forward to defend his title at Emerald Downs.
|Breeder / Owner
|Anthony's Cross
|Eoin G. Harty
|Awesome Gem
|Bonfire Knight (GB)
|Steven Miyadi
|Hudson Landing
|Blaine D. Wright
|Michael the Man
|Frank Lucarelli
|Positive Response
|William E. Morey
|Where's the Remote
|Mike R. Mitchell
|New York Stallion S.
|New York Stallion S.
|Irish Day S.
|Emerald Downs H.
|Southern Truce S.


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Well that was part of the problem, he HAS a permit as it's deer season here now. But a knife is not one of the approved methods to hunt them with so if the deer hadn't been injured he could have gotten in quite a bit of trouble.
It's ribs had been shattered and the GW determined it was a mortal wound, even though it probably would have simply laid down and starved to death.
The cops had to respond to the call that lady made and they normally will simply send you a permit in the mail around here for a kill involving an vehicle. I think the GW just wanted to see someone who was dumb enough to go after a deer with a knife, or he didn't believe what he was hearing.
I've actually known 3 cases (counting this one) where someone went after a deer with a knife and my buddy was involved in two but the last one was 20 plus years ago. One was actually an Elk in Colorado.
He's getting too old for that kind of crap
Its only a deer lmao...
Now if you hopped on the back of a tiger...well....
That is a great story. On a side story I almost got myself thanksgiving dinner the other day.
You sir, have obviously never been on the buisness end of a set of deer hooves. I have seen the end result of that. They can easily split the skull of a full grown wolf. And just because they are herbavoris doesn't mean that a 13 pt doesn't know how to use that rack as a weapon, 'cus he does.
I rode to work yesterday. 42* when I left the house. Went to an indie at lunch to talk about having some oil leaks fixed. Was 47* when I rode home. Had a smile on my face the whole time (except while I was at work)!!
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Lip Surgery Q&A
Flatten + Lip Surgery
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Is There a Procedure That Will Flatten my Protruding Upper Lip? (photo)
I have never gotten any sort of lip augmentation/surgery done but my upper lip protrudes and gives off that unappealing "duck lip" look that you see... READ MORE
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Triple-negative breast cancer
Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or Her2/neu.[1] This makes it more difficult to treat since most hormone therapies target one of the three receptors, so triple-negative cancers often require combination therapies. Triple negative is sometimes used as a surrogate term for basal-like; however, more detailed classification may provide better guidance for treatment and better estimates for prognosis.[2]
Triple-negative breast cancers comprise a very heterogeneous group of cancers. There are conflicting information over prognosis for the various subtypes but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required.[3] Some types of triple-negative breast cancer are known to be more aggressive with poor prognosis, while other types have very similar or better prognosis than hormone receptor positive breast cancers.[4] Pooled data of all triple-negative subtypes suggest that with optimal treatment 20-year survival rates are very close to those of hormone positive cancer.[5]
Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3–5 years but drops sharply and substantially below that of hormone-positive breast cancers after that. This relapse pattern has been recognized for all types of triple-negative cancers for which sufficient data exists although the absolute relapse and survival rates differ across subtypes.[5][4]
One known cause of triple negative breast cancer is germline mutations. These are alterations within the heritable lineage that is being passed down to the offspring. 15% of TNBC can be traced back to germline mutations that are within the BRCA1 and BRCA2 genes (Song 2014). These genes were identified as high risk for triple negative due to their high predisposition for cancers of the breasts, ovaries, pancreas, and prostate (Pruss 2014). Changes or mutations in 19p13.1 and MDM4 loci have also been associated with triple negative breast cancer, but not other forms of breast cancer, thus triple negative tumors may be distinguished from other breast cancer subtypes by a unique pattern of common and rare germline alterations (Kristen 2013).
Triple-negative breast cancers (TNBC) are sometimes classified into "basal-type" and other cancers; however, there is no standard classification scheme. Basal type cancers are frequently defined by cytokeratin 5/6 and EGFR staining. However, no clear criteria or cutoff values have been standardized yet.[2] About 75% of basal-type breast cancers are triple negative.
Some TNBC overexpress epidermal growth factor receptor (EGFR)[6][7] or transmembrane glycoprotein NMB (GPNMB).
Upon histologic examination, triple-negative breast tumors mostly fall into the categories of secretory cell carcinoma or adenoid cystic types (both considered less aggressive); medullary cancers and grade 3 invasive ductal carcinomas with no specific subtype; and highly aggressive metastatic cancers.[2] Medullary TNBC in younger women are frequently BRCA1-related.
Rare forms of triple-negative breast cancer are apocrine and squamous carcinoma. Inflammatory breast cancer is also frequently triple negative.
Many proteins such as Caveolin 1/2, Survivin are researched as possible classification or prognostic factors.
Standard treatment is surgery with adjuvant chemotherapy and radiotherapy. As a variation, neoadjuvant chemotherapy is very frequently used for triple-negative breast cancers. This allows for a higher rate of breast-conserving surgeries and by evaluating the response to the chemotherapy gives important clues about the individual responsiveness of the particular cancer to chemotherapy.
In addition to chemotherapy, an additive called Didox can be added to aid in the reduction of drug resistance and further treatment efforts. Didox is used to inhibit ribonucleotide reductase M2 (RRM2) which contributes to the cells resistance of the chemotherapy treatment resulting in a large number of relapse (Wilson 2016). RRM2 is upregulated within these specific Triple Negative cancer cells leading to a higher rate of drug resistance and inability to slow or stop the tumor progression which leads to more aggressive forms of triple negative breast cancer that are often fatal (Wilson 2016).
TNBCs are generally very susceptible to chemotherapy. In some cases, however, early complete response does not correlate with overall survival. This makes it particularly complicated to find the optimal chemotherapy. Adding a taxane to the chemotherapy appears to improve outcome substantially.[2]
BRCA1-related triple-negative breast cancer appear to be particularly susceptible to chemotherapy including platinum-based agents and taxanes.
Triple-negative breast cancer accounts for approximately 15%-25% of all breast cancer cases. The overall proportion of TNBC is very similar in all age groups. Younger women have a higher rate of basal or BRCA related TNBC while older women have a higher proportion of apocrine, normal-like and rare subtypes including neuroendocrine TNBC.[2]
Among younger women, African American and Hispanic women have a higher risk of TNBC,[8] with African Americans facing worse prognosis than other ethnic groups.[9]
In 2009, a case-control study of 187 triple-negative breast cancer patients described a 2.5 increased risk for triple-negative breast cancer in women who used oral contraceptives (OCs) for more than one year compared to women who used OCs for less than one year or never.[10] The increased risk for triple-negative breast cancer was 4.2 among women 40 years of age or younger who used OCs for more than one year, while there was no increased risk for women between the ages of 41 and 45. Also, as duration of OC use increased, triple-negative breast cancer risk increased.
Clinical research/trials[edit]
Angiogenesis and EGFR (HER-1) inhibitors are frequently tested in experimental settings and have shown efficacy.[citation needed] Treatment modalities are not sufficiently established for normal use, and it is unclear in which stage they are best used and which patients would profit.
By 2009 A number of new strategies for TNBC were being tested in clinical trials,[11] including the PARP inhibitor BSI 201,[12] NK012.[13]
A novel antibody-drug conjugate known as Glembatumumab vedotin (CDX-011), which targets the protein GPNMB, has also shown encouraging clinical trial results in 2009.[14]
PARP inhibitors had shown some promise in early trials[12] but failed in some later trials.[15]
Nov 2013: An accelerated approval Phase II clinical trial (METRIC) investigating glembatumumab vedotin versus capecitabine has begun, expected to enroll 300 patients with GPNMB-expressing metastatic TNBC.[16]
|This section needs to be updated. (February 2016)
Three early stage trials reported TNBC results in June 2016, for IMMU-132, Vantictumab, and atezolizumab in combination with the chemotherapy nab-paclitaxel.[17]
Pre-clinical research/speculations[edit]
Triple-negative breast cancers (TNBC) have, on average, significantly higher fluorine-18 fluorodeoxyglucose (FDG) uptake (measured by the SUVmax values) compared with uptake in ER+/PR+/HER2- tumors using fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET).[18] It is speculated that enhanced glycolysis in these tumors is probably related to their aggressive biology.
The widely used diabetes drug, metformin, holds promise for the treatment of triple-negative breast cancer.[19] In addition metformin may influence cancer cells through indirect (insulin-mediated) effects, or it may directly affect cell proliferation and apoptosis of cancer cells. Epidemiologic and preclinical lab studies indicate that metformin has anti-tumor effects, via at least two mechanisms, both involving activation of the AMP-activated protein kinase (AMPK). A large-scale phase III trial of metformin in the adjuvant breast cancer setting is being planned in 2009.[20]
Triple-negative breast cancer cells rely on glutathione-S-transferase Pi1, and an inhibitor (LAS17) shows encouraging results in a pre-clinical study[21]
See also[edit]
- ^ Foulkes, William D., Ian E. Smith, and Jorge S. Reis-Filho. "Triple-negative breast cancer." New England journal of medicine 363.20 (2010): 1938-1948.
- ^ a b c d e Hudis, C. A.; Gianni, L. (2011). "Triple-Negative Breast Cancer: An Unmet Medical Need". The Oncologist. 16: 1–11. PMID 21278435. doi:10.1634/theoncologist.2011-S1-01.
- ^ Albergaria, A.; Ricardo, S.; Milanezi, F.; Carneiro, V. T.; Amendoeira, I.; Vieira, D.; Cameselle-Teijeiro, J.; Schmitt, F. (2011). "Nottingham Prognostic Index in Triple-Negative Breast Cancer: A reliable prognostic tool?". BMC Cancer. 11: 299. PMC 3151231 . PMID 21762477. doi:10.1186/1471-2407-11-299.
- ^ a b Cheang, M. C. U.; Voduc, D.; Bajdik, C.; Leung, S.; McKinney, S.; Chia, S. K.; Perou, C. M.; Nielsen, T. O. (2008). "Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype". Clinical Cancer Research. 14 (5): 1368–1376. PMID 18316557. doi:10.1158/1078-0432.CCR-07-1658.
- ^ a b Hudis, C. A.; Gianni, L. (2011). "Triple-Negative Breast Cancer: An Unmet Medical Need". The Oncologist. 16: 1–11. PMID 21278435. doi:10.1634/theoncologist.2011-S1-01.
- ^ Feb 2009 Breast Cancer Watch
- ^ Anders (2008). "Understanding and Treating Triple-Negative Breast Cancer".
- ^ Reynolds, Sharon (2007-07-24). "Spotlight: Triple-Negative Breast Cancer Disproportionately Affects African American and Hispanic Women". National Cancer Institute. Retrieved 2008-10-13.
- ^ Chustecka, Zosia (2007-03-19). "Survival Disadvantage Seen for Triple-Negative Breast Cancer". Medscape Medical News. Retrieved 2008-10-13.
- ^ Dolle JM, Daling JR, White E, Brinton LA, Doody DR, Porter PL, Malone KE (2009). "Risk Factors for Triple-Negative Breast Cancer in Women Under Age 45". Cancer Epidemiology, Biomarkers & Prevention. 18 (4): 1157–1166. PMC 2754710 . PMID 19336554. doi:10.1158/1055-9965.EPI-08-1005.
- ^ Anders C; Carey, LA (2008). "Understanding and Treating Triple-Negative Breast Cancer". Oncology. 22 (11): 1233–9; discussion 1239–40, 1243. PMC 2868264 . PMID 18980022.
- ^ a b "SABCS: PARP Inhibitor Data Called 'Spectacular' "; Dec 2009
- ^ "A Study of NK012 in Patients With Advanced, Metastatic Triple Negative Breast Cancer".
- ^ Burris (2009). "A Phase I/II Study of CR011-vcMMAE (CDX-011), an Antibody-Drug Conjugate,in Patients with Locally Advanced or Metastatic Breast Cancer" (PDF).
- ^ Guha, M. (2011). "PARP inhibitors stumble in breast cancer". Nature Biotechnology. 29 (5): 373–374. PMID 21552220. doi:10.1038/nbt0511-373.
- ^ Clinical trial number NCT01997333 for "Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer (METRIC)" at ClinicalTrials.gov
- ^ Finally, targeted therapies for triple-negative breast cancer. June 2016
- ^ Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A (2008). "Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization". Cancer. 112 (5): 995–1000. PMID 18098228. doi:10.1002/cncr.23226.
- ^ Jiralerspong S, Gonzalez-Angulo AM, Hung MC (2009). "Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?". Cell Cycle. 8 (13): 2031–40. PMID 19440038. doi:10.4161/cc.8.17.9502.
- ^ Goodwin PJ, Ligibel JA, Stambolic V (2009). "Metformin in breast cancer: time for action". American Society of Clinical Oncology. 27 (20): 3271–3273. PMID 19487373. doi:10.1200/JCO.2009.22.1630.
- ^ Louie, Sharon M.; Grossman, Elizabeth A.; Crawford, Lisa A.; Ding, Lucky; Camarda, Roman; Huffman, Tucker R.; Miyamoto, David K.; Goga, Andrei; Weerapana, Eranthie; Nomura, Daniel (2016-05-19). "GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity". Cell Chemical Biology. 23 (5): 567–578. ISSN 2451-9456. PMID 27185638. doi:10.1016/j.chembiol.2016.03.017.
Alanazi, Ibrahim O., and Zahid Khan. "Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications." Asian Pacific Journal of Cancer Prevention 17.2 (2016): 445-453.
Lehmann, Brian D., and Jennifer A. Pietenpol. "Identification and use of biomarkers in treatment strategies for triple‐negative breast cancer subtypes." The Journal of pathology 232.2 (2014): 142-150.
Pruss, Dmitry, et al. "Development and validation of a new algorithm for the reclassification of genetic variants identified in the BRCA1 and BRCA2 genes." Breast cancer research and treatment 147.1 (2014): 119-132.
Song, Honglin, et al. "The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population." Human molecular genetics (2014): ddu172.
Stevens, Kristen N., Celine M. Vachon, and Fergus J. Couch. "Genetic susceptibility to triple-negative breast cancer." Cancer research 73.7 (2013): 2025-2030.
Wilson, Elizabeth A., Howard L. Elford, and Jesika S. Faridi. "Successfully targeting triple negative breast cancer using combination therapy of Didox and Doxorubicin with reduced cardiotoxicity." Cancer Research 76.14 Supplement (2016): 4689-4689.


text:
Andrew (Boy) Charlton Pool
Join the revolution
Your pass to enjoy the City's pools and fitness centres.360 membership
Pool with a view
Set on Woolloomooloo Bay near the Royal Botanic Gardens, the Andrew (Boy) Charlton Pool (aka the ABC Pool) offers patrons breathtaking views of Sydney Harbour.
The City of Sydney has put a range of features in place to make sure the pool is accessible to people with disabilities.
The pools
Our 50-metre outdoor pool is perfect for lap swimming. It has 8 lanes and ranges in depth from 1.2 to 2 metres. The pool is heated from 1 September to 30 April and filled with chemically treated salt water.
The smaller (20 metre) pool is 1 metre deep throughout and perfect for those who are learning to swim or just want to have fun. It is heated to 28ºC and also contains chemically treated salt water. This pool has a shade cover to protect your skin from the sun.
Other facilities
- Seats on a shaded terrace.
- Daybeds.
- Licensed café with outdoor deck area.
- Massage centre.
- Yoga school.
Classes and coaching
- 'Learn to Swim' courses for children and adults.
- Coaching programs.
- Private swimming lessons.
- Club/squad training.
- Group fitness sessions including cross training, martial arts and kayaking.
- Biathlon competitions.
Special events
The ABC Pool can be hired for school swimming carnivals and squad training.
The Poolside Cafe is available for corporate events, product launches, fashion shows, weddings, private parties and a range of other functions.
And more ...
The ABC Pool is operated by Belgravia Leisure in partnership with the City. Admission fees are summarised in the table below.
Opening hours
Season: Friday 1 September 2017 to Sunday 30 April 2018
Non-daylight savingMonday to Sunday: 6am to 7pm
Daylight saving
Monday to Sunday: 6am to 8pm
Public holidays: 7am to 7pm.
Closed on Good Friday and Christmas Day.
Opening hours may change on New Year's Eve and New Year's Day. Please check website closer to the date.
1C Mrs Macquaries Road
The Domain NSW 2000 www.abcpool.org 02 9358 668602 9358 6540 firstname.lastname@example.com
Admission fees
Current fees and charges for the 2016/17 season are listed below. All prices include GST.
|360 City access card*
|Pool entry
|Multi visit pass (20 visits)
* The City access card is for residents on a low income. Contact the centre for more information.
Other fees (pool only)
- Additional family member: $2.50
- Spectator: $3.40
Last updated: Sunday, 30 April 2017


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Kind of worried here...
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Master Member
Join Date: Oct 2013
Location: Vancouver, WA (USA)
Posts: 750
Kind of worried here...
Yogi is now 16 weeks. He's very good with strangers and has the typical "Omg! Peeeeeople!" when we meet someone. Yesterday I had something weird happen.
Neighbor had a company working on their roof and all the workers were standing in the yard eating lunch. Yogi showed some interest in the men and I thought it would be a good opportunity to socialize. The guys had big boots and coveralls on. Three of the men stood there and held their hands out to say hi. That went fine. Then a fourth guy walked over and was talking to the other workers. Yogi immediately stood from a sit (getting rubs from other workers) and his tail went straight out/up. The guy saw Yogi and said, "Beautiful shepherd, I love them! Hi pupppyyyyy. Who's a good boy!" while holding his hand out. Yogi put all his weight into his front legs, put his head lower and all the hair went up on his back (all the long wavy hair) and started a very low growling bark at him. A bark I've never heard before. A scary adult bark. It made all the hair on my arms and neck stand straight up. Yes, I know. He's a puppy still but I've never heard a growling bark like that. Usually he's got this lighthearted puppy bark that says "play with me!" but this was clearly a warning to "stay away". I don't think he was scared because he didn't retreat like he normally does if something scares him and he never barks. He just sidles up really close and I deal with whatever it is that gave him fear. I normally would think, "Oh he's probably scared" but I know my dog. I think he was protecting me, which is weird. The only thing different about this guy was he had long hair. I look back at all the places I've taken him though and he's never had a reaction to a man with longer hair after meeting them - there's only been a few. I apologized profusely. Any insight into his behavior? My husband saw all of this and asked if the guys made ME nervous because maybe Yogi was picking up on it. I said no. My husband then tried to take him back up to the guy to see if there would be a different reaction but the guy immediately got into his truck and took off.
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Taylor Swift's Fearless Album (Song List + mp3 song downloads)
Taylor Swift's second album entitled Fearless, which contains 11 tracks all written by the American pop and country music artist herself, is going to debut today November 11, 2008 on various music and video stores. I know many are already searching the internet for free mp3 song downloads, Taylor swift lyrics, and even music videos. I hope this helps a bit. I've already heard some songs from her newly released album; the recent ones I've heard were You Belong to Me, Hey Stephen, Tell Me Why, White Horse, and Forever and Always. She even did a duet with the popular MySpace singer Colbie Caillat in one of her songs entitled Breathe. Taylor's songs focus more on a mainstream country-pop appeal, and they truly capture the hearts of her young listeners. And by the way, she looks hot in her new album cover.
Check out Taylor Swift's Fearless album song list after the jump. Enjoy!
- Fearless
- Fifteen
- Love Story
- Hey Stephen
- White Horse
- You Belong with Me
- Breathe duet with Colbie Caillat
- Tell Me Why
- You're Not Sorry
- The Way I Loved You
- Forever & Always
- The Best Day
- Change
If you are looking for some free mp3′s on this blog, I'm sure you'll find them if you search the internet. It's quite big actually and its quite simple if you really look for the songs.


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Gerber is dedicated to developing life-saving, mission-essential gear for those who serve.
Built on the successful one-handed design of the MP600 series, this updated version has a more focused objective. With a longer Phillips driver, a serrated/fine edge blade, a carbon scraper for maintenance, and a front sight adjustment tool it will quickly be indispensable.
Gerber is dedicated to developing life-saving, mission-essential gear for those who serve.
It's extremely difficult to improve on a Gerber Military classic, but we've done it with the MP600 Sight Tool. Built with the same one-handed opening technology as our MP600, our updated version has a longer Phillips driver, a combined serrated and fine edge blade, a carbon scraper for weapons maintenance and a newly designed, super-durable front sight adjustment tool. The MP600ST is Gerber's new standard in Military issue multi-pliers.
*The MP600ST military version can be found here.
Butterfly Opening Multi-Tool
Solid State Multi-Tool
Solid State Multi-Tool
-The one hand opening features is perfect for minimum movements within a patrol base or other close quarter situations.
-I keep the MP600ST w/in reach to hammer out any protocol deviation that may arise, making solutions "Too Easy."
*Thank you Gerber
Great tool. Quite versatile and great price. Excellent customer service.
The Gerber 30-000588 MP600 ST Sight Tool provides everything I need. I never leave home with out it.
USA Made.
Thanks Gerber
Al C.
great tool use it almost every day. had the older version while serving in afghanistan
Great Gerber Multi tool. Every Cowboy need a Gerber MP 600!! Made in the USA
I've carried one for over 3 years now and have never borrowed a tool from anyone. This one multi-tool more than serves its' purpose. It is indestructible!
First off: assembled in USA made in China!! Great quality product & made too last...Handy Farm tool...
Great Tool !! its not Made in the USA:( its made in China!! Assembled in the USA:(
Thanks Gerber !!
Best tool I own.
I never leave home without out my gerbers!
On par with with leatherman at a much better price. Use my all the time, high quality and great tool selection.
The best warranty! The best workmanship! The Best design! The Best durability! The best one hand opener! This will be the FIRST AND LAST TOOL YOU WILL EVER NEED!
I love this knife it's great for most things. I use this knife for scouts. I wish they'd make the bottle opener bigger.
very durable construction and like the stell good job gerber!!!!!!
Nothing against Gerber, as I use and love just about everything they make. But how the heck are you people who "want one" giving an item a five-star review. You clearly do not HAVE one and should certainly not be giving it a rating until you do.
On that note, this thing really is wonderful. I use it at work on a daily basis. My only complaint, as others have also pointed out, is that replacement parts are about IMPOSSIBLE to find/get.
Used one the whole time I was a DS and loved it. Bought my own and the front sight post adjuster broke the first time I used it. Need a replacement part but can't find one!
I had mine in the Military as well as it saves lives on both sides!
I love it, and want one!!!
i want it!!!! when will it be available?


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Forums Home » Food & Nutrition
8 mo old kitten getting tired of Before Grain canned foodDiscuss ways to improve the quality of your cat's life and longevity through proper nutrition; a place for all of your questions and answers about feeding your kitty!
Please keep discussions fun, friendly, and helpful at all times. Non-informative posts criticizing a particular brand or another poster's choice of food are not allowed in this Forum. References to any brand of food as "junk," "garbage," or other harsh names will be removed.


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Rolls-Royce Phantom Hire: Waltham Forest
Waltham Forest
Rolls-Royce Phantom Hire is available in the London borough of Waltham Forest, through London Phantoms today. It is situated in the north-east of London, and its population of 230,000 people live within an area of 15 square miles. The borough could roughly be divided into two areas, with the northern half containing more green and open spaces with a more affluent population than the southern half.
Rolls-Royce Phantom Hire in Waltham Forest
Most visitors to London will wish to visit the major landmarks, but Waltham Forest also has some interesting attractions of its own to offer which can ideally be toured in total opulence inside a Rolls-Royce Phantom. One such place is the William Morris gallery, which is a museum devoted to England's most famous designer. There are many displays of fabrics, carpets and furniture housed here, and a visit is a pleasant way to spend an hour or two.
Whilst on the subject of museums, the Vestry House Museum is another place which is suggested to visit. The museum contains many artefacts and exhibits detailing the development of the area, and it is also a good place to find out which of the more hidden gems of the area are also worth seeing.
For something a little different, visitors to the area might like to visit Walthamstow Greyhound Stadium. People who have never been to see greyhound racing before should prepare themselves for a great night out! The atmosphere is unparalleled, and it is a great chance to see a side to London life that might otherwise be missed. You can add to the atmosphere by arriving and leaving in your own chauffeur-driven Rolls-Royce Phantom.
In order to see the other major landmarks of London, it might be a nice idea to consider hiring a rolls Royce-Phantom for the day, especially if time is limited. They will get you to where you want to be in the most prompt time possible, and will always be waiting for you fifteen minutes before any pre-arranged pick-up time. Take the hassle out of sight seeing, and see London and Waltham Forest in style with a Rolls-Royce Phantom!
We also have a whole host of other cars as well as the Rolls-Royce Phantom which are available for wedding hire and event/corporate/casual hire in the Waltham Forest borough too, including a Rolls-Royce Ghost, Bentleys, Mercedes and a Maybach. Contact us today.


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ODOT plans changes for flyover ramp
ODOT's study of the I-5/OR 217 northbound ramp has found no structural issues that would lead to an increase in crashes. Our review of historical data shows speed too fast for conditions has played a role in almost two-thirds of all 82 reported crashes on the ramp in an 11.5-year time period, between the time it opened in June 2001 and the end of 2012. Average traffic volume grew from 24,080 a day in 2002 to 32,160 a day in 2012. That computes to more than 100 million vehicle trips across the ramp since it opened—or almost 1 million vehicle trips each month.
"We are taking even more steps to raise awareness that the advisory speed is 35 mph," said Jason Tell, ODOT manager for the Portland area. "And wet roads require greater care when driving, especially on any ramp."
What ODOT has done to study the issue
•ODOT bridge engineers examined the bridge joint near the beginning of the bridge in January 2014 as part of a routine bridge inspection performed every two years. After reports of new crashes this spring, ODOT inspectors again examined the joint. In both cases, they found the joint within specifications. The current condition of the joint has not noticeably changed since 2006.
•ODOT bridge engineers examined the structure itself—the piers and foundation, as well as the joints and deck. They found no issues of concern.
•ODOT crews performed a friction test on the deck of the bridge. The test showed some parts of the deck had greater friction than the last test in 2007 and some parts had less.
What ODOT is doing to reduce further crashes on the ramp
•ODOT plans to install an electronic warning sign at the start of the ramp by this fall. The sign will display an image of a skidding vehicle when laser sensors detect that rain, snow or ice has reduced road surface traction. Similar signs were installed last winter on the ramp at the north end of OR 217 where it joins U.S. 26 westbound.
•ODOT installed a lighted variable message sign at the start of the ramp in May in response to concerns about crashes, to remind travelers of the advisory speed. This sign will be removed when the electronic sign described above is installed.
•We installed large and bright 35 mph speed signs on both sides of the ramp. And we installed large chevrons (arrows) along the first curve of the ramp.
•As part of routine maintenance and in an abundance of caution, ODOT will seal the deck by mid-August.
•ODOT will record a camera feed documenting traffic patterns on the ramp when the roadway is wet. Speed can be determined from the images. ODOT generally does not record images from our cameras, but we will do so in this case, specifically to study ramp traffic patterns in wet weather.
Safety is a shared responsibility
"ODOT is committed to maintaining a safe and efficient highway system," ODOT Region Manager Tell said. "And we also ask drivers to do their part: Please follow the advisory speed on all ramps."


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The media has repeatedly publicized studies that purportedly found men do not do their share of housework. These studies, including one by the United Nations, were seriously flawed as they did not account for work outside the home and/or failed to factor many traditionally male forms of housework. The mass media also virtually ignored subsequent...
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- Phil Cook, Author/Journalist
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The abridged version: rod knock on my '05 WRX w/ 2.0L (stage 2 Cobb OTS map) = 2.5L hybrid build. Machines Gone Wild in Kendal did the build. 319.50hp, 293.90 torque at 16 PSI (very conservative tune).
2.5L Hybrid setup
Kelford Cams
Cosworth Head Gaskets
CP Pistons
Valve Springs
Head Studs
Perrin TMIC
DW 650cc injectors
Walbro 255
Blouch 18g 8cm
Cobb Intake w/airbox
New stock parts: clutch disc, timing belt, oil pump, v-belt, accessory belt, water pump
Gauges: AEM UEGO (wideband A/F), oil pressure, boost
Edit: Newest Tune and info Below....
Got a retune and the only changes are as follows:
Perrin Inlet
Grimmspeed EBCS
NGK Iridium Spark Plugs (one step colder)
STi Oil Pan w/KillerB Oil Pickup
Kartboy Pitchstop
More Boost (was 16PSI, now 19PSI)
Old dyno results: 318.85whp, 288.37trq (16PSI, Temp: 87.90F, 41% humidity)
Current/New: 332.47whp, 338.78trq (19PSI, Temp: 97.37F, 28% humidity)
Both were on the same DynoJet and done by the same tuner, who also built my block (Gregg of Machines Gone Wild). The car has almost 85K miles and the block has 24K.


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Christie's offers unusual Hannibal work by Poussin
By Mike Collett-White
LONDON (Reuters) - Auction house Christie's will offer an unconventional painting by French classical artist Nicolas Poussin, depicting Carthaginian general Hannibal astride an elephant, in July, expecting it to fetch 3-5 million pounds ($4.5-7.5 million).
The early work is not considered one of the artist's best and was little known until it appeared in public at an exhibition in Rouen in northern France in 1961.
But the auction house is hoping that its provenance - the painting was originally in the collection of Poussin's greatest patron in Rome, scholar Cassiano dal Pozzo - will help boost interest when it goes under the hammer in London on July 2.
"It was painted right after he arrived in Rome and he obviously developed as his career progressed," said Georgina Wilsenach, head of old master and British paintings at Christie's.
"I don't think that takes away its appeal," she added. "It is quite unusual. In terms of (Poussin) works coming up for auction, I think that most are religious paintings or mythological subjects."
The canvas, dating from the mid-1620s and measuring around 1.0 by 1.35 meters, depicts Hannibal on an elephant leading his troops on the fabled journey from Iberia into northern Italy via the Alps to attack Roman forces in the Second Punic War.
The dramatic early picture from an artist famed for works like "The Death of Germanicus" and "The Abduction of the Sabine Women" was snapped up by Cassanio for the then extravagant sum of 40 scudi.
According to Christie's, Poussin's patron paid over the odds for Hannibal in an apparent bid to help the artist who had fallen seriously ill while in Rome and, unable to work, found himself penniless. Continued...


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The Bursar's Office manages student accounts. We issue online bills for tuition and fees, credit your account for payments you make and that you may receive through financial aid. We also offer a payment plan known as UPay. If you are a Perkins Loan Holder or a Nurse Faculty Loan Holder, contact our loan repayment services.
StudentsMake sure you log into your SPIRE account where you manage every aspect of your University account which includes your bills, To Do list and Holds.
- Use our Checklist For Students.
- Learn how to view and pay your bill in QuikPAY.
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Parents and GuardiansBecome an Authorized Payer so you can view and pay the bill online in QuikPAY.
- Use our Checklist for Parents.
- Ask your student to log into SPIRE and check their list of Holds and To Dos.
- Read Money Matters: A guide to financial aid and the Bursar's online billing and payment system.
- Understand FERPA and get a FERPA Access code.
Student records are confidential and protected under the Family Educational Rights and Privacy Act (FERPA). Students may elect to set up a FERPA Privacy Waiver to allow parents, guardians or other third parties to obtain information about their Bursar bill, Financial Aid and Housing. We will not disclose information to anyone who has not been designated by the student in their FERPA waiver.
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It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is voluntary but will dramatically boost your chances of getting interest from other members on the website. Write about yourself, your hobbies and upload a nice photo of yourself.
Utilise our website's sophisticated search to locate members who satisfy your requirements. Or just leaf through listings and locate folks that appeal to you.
Identified someone who is attractive to you? Send them a message or just a wink and see if anything happens. With a little luck you'll be on your way to locating your ideal partner.
You won't regret it


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From 3 July 2017, Queensland will operate under new planning legislation.
The new planning laws provide the basis for securing the liveability, sustainability and prosperity of our communities, both now and into the future. The legislation will deliver a transparent and efficient system that contributes to investment and jobs, and embraces genuine community engagement. Read more.
The new legislation strives to protect our heritage, environment and establish a bright future for the next generation of Queenslanders.
Development across the state must be done in a fair, consistent and efficient way to meet community aspirations and deliver benefits to our economy.
Over the next 12 months, as we get out and about talking to Queenslanders about the new system, we'll keep you up to date on all our news from across the state.
8 March 2017
The Minister's Guidelines and Rules (MGR) is the key instrument that will mandate how local planning schemes and other local planning instruments are made (or changed).Read more ...
10 February 2017
Consultation on the draft Planning Regulation, updated State Planning Policy, and revised State Development Assessment Provisions has now closed.Read more ...
5 January 2017
A new statutory instrument – the Development Assessment Rules – will set out a standardised development assessment process that will ensure applications are progressed in a consistent and transparent way, in accordance with community expectations.Read more ...


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darren liew, a 14 year old male from Singapore asks on June 24, 2002,How many times a year can you see the eclipse of the moon???
viewed 16337 times
A quick Internet search yielded the NASA eclipse website. The site details solar and lunar eclipses for the next few thousand years. This year (2002) there are 3 lunar eclipses. Next year there are two.
Note: All submissions are moderated prior to posting.
If you found this answer useful, please consider making a small donation to science.ca.


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Has anyone got the packs from doing the multiplayer stuff over the weekend? Isn't sometime today we get them?
P.S You up for some MP tonight Shambles?
Edited by MattyB2007 at 13:00:32 20-03-2012
#8526310, By MattyB2007 Mass Effect 3
MattyB2007 2,858 posts
Seen 13 hours ago
Registered 11 years ago


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So we're just going to assume that this is not on of Dana White's favorite weeks to be Dana White.
GQ Magazine just recently named the UFC President as the eighth Sleaziest Man in Sports in their most recent issue. They did not hesitate to go in on White for all of the claims of underpaying fighters and his aggressive flaunting of money in Vegas.
The short blurb written to describe him states:
Turns out underpaying your UFC employees, bullying rivals, and generally impersonating Don King as a bald white guy doesn't do wonders for you charisma!
People on the list were then ranked using a pictoral key, and next to Dana's is a stack of money, symbolizing that the magazine found his primary offense to be "Greedy Sleaze."
What's worse, is that he was just one space below War Machine on the list. Ouch.
Here is the entire list:
10. Bobby Petrino
9. Lance Armstrong
8. Dana White
7. War Machine
6. Tiki Barber
5. Chad Curtis
4. Isiah Thomas
3. Sepp Blatter
2. Aaron Hernandez
1. Donald Sterling


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TNA SLAMMIVERSARY: Hernandez vs. Kid Kash
Mike Tenay and Taz discuss the card for Slammiversary tonight including Bobby Roode defending the TNA Championship against Sting. Plus, the first inductee into the TNA Hall of Fame will be announced.
Kid Kash vs. Hernandez
Kid Kash with a few kicks early on. Hernandez launches Kash across the ring and through the ropes with a big shoulder block. Kash jumps up to the ring apron to complain to the referee and Hernandez launches him back in over the top rope. Hernandez launches Kash to the corner with force. Kash wraps up the arm and shoulder of Hernandez in the ropes. Kash with some big chops to Hernandez. Repeated chops and kicks from Kash. Kash with a springboard huricanrana that sends Hernandez face first down into the mat. Kash follows that up with a huge swinging tornado DDT. Hernandez recovers on the ring apron and then slingshots himself in catching Kash with a flying shoulder block. Hernandez with another shoulder block that launches Kash to the outside. Hernandez hits the ropes and jumps over the top rope taking out Kash! Back in the ring, Kash counters a Border Toss attempt. Kash dropkicks Hernandez into the corner. Hernandez pulls himself up to the top turnbuckle, sends Kash back to the mat and connects with a top rope body splash. Hernandez gets the pinfall.
Winner: Hernandez
Video airs of TNA's Greatest Moment #3: AJ Styles becoming the first ever X Division Champion.
* TNA TV Champion Devon and Garett Bischoff vs. Robbie E and Robbie T is up next.


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London visit Natural H istory Museum The 5th was the day of Elena and me. Visited the museum of natural history which was once part of the British Museum where we play.
Chelsea Field We were also the sides of the ground but not inside because we had not planned, was going to the field and back to see what else oh we got photos on a wall that was next to the field.
Hyde park Finally we went to Hyde park which is the largest park in London, there walked a few hours r id ing in boats, eating ice cream and some climbed a tree.


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Why are architects volunteering new airport plans for London? Answer shortly.
First the politics. On Tuesday Shadow Transport Secretary Angela Eagle called for Sir Howard Davies's review of London's airport strategy to be "fast-tracked" to complete before the next election. Political pressure is growing on the government to start spending on an exploration of the other options.
Hey Presto! Ken Shuttleworth of Make Architects last week came up with plans to add three four kilometre runways at Stansted. Chris Williamson of architects Weston Williamson was on local TV this week pushing for three runways at Luton. Foster + Partners want a new airport on the Hoo peninsular in Kent. US firm Gensler suggest a floating airstrip in the Thames Estuary called London Britannia Airport.
Why come up with plans? Nobody has told the architects to do so. Nobody is paying. Two reasons. One, who better? Architects love dreaming up ideas that aren't rooted in the realities of trying to lift capacity. But there is a baser reason: establishing credentials before the flow of consulting fees that will come as the Davies Commission gets down to work.
- More about:
- Airports
- Architects
- Architecture
- Artists
- Consultancy
- Luton (town)


text: I cannot stop thinking about this topic. Why is it automatically assumed that it is inferior, unsophisticated, undesirable, or even shameful to be sentimental, emotionally honest, and vulnerable? Why is it so bad and so scary to lay your pain and joy bare to all the world to see? I am thinking of the various David Wilson's programs that are often criticized for being boring, sentimental, or cheesy. Take for example The Way We Were he made for Dube and Davison last season. It makes perfect sense knowing their history. Take for example my favorite of all of Michelle Kwan's programs --- not any competitive program but the exhibition "Fields of Gold," after she did not win the Olympic gold medal. It occurred to me that intellectuals tend to celebrate perfect, flawless works that are to be admired. A creation is judged by how few blemishes it contains. Diamonds are a highly desirable object, because it is the hardest substance and resistant to cuts and scratches. We celebrate people and feelings that cannot be harmed and hurt. Strength and toughness. Pure beauty. The absence of vulnerability. The purer the better. Being earnest is far worse than being stupid or nasty. Yet that is not what people respond to. People respond to schmaltz. You can dismiss it as shallow, silly, simple-minded, and naive, but in reality emotions have a much stronger grip on our brain (or what is known as the heart) than intellectual thoughts. And what connects us is emotional empathy between any two people. Although admiration for something hard and flawless is powerful, it is no match for touching one's soft spot in the heart. The cortex of consciousness looks down on the lowly emotional brain, but even the rationale brain has learned enough science to realize that it is the emotional brain that rules our behaviors and instincts. (Well, what am I trying to say? It is late and I cannot sleep. I am rambling.) When honest emotions are laid out with no pretension, no shell of self-protection, no attempt to impress or manipulate, no intention to seduce or conquer, no dressing-up, no projection of fear, when all you give is "Look, this is my pain, my errors, my vulnerability, my true self, and nothing else," I think you get something that resonates. Perhaps emotions get a bad reputation because they are susceptible to manipulations by falsehood and because they have no advocate in front of the abstract mind. Yet, there is a distinctive difference between cheap, manipulative attempts and honesty. I do believe that most people can tell the difference when they are presented with something that is true and raw. Emotions are by nature not complex or abstract, not rationale, not cool, not flawless, not invincible. It takes enormous courage and strength to allow others, even strangers, to access one's most tender and vulnerable emotions. It takes enormous faith in human empathy and kindness to give a piece of oneself to others and expect them to treat it with tenderness and care. Most of us cannot. Most of us are afraid. I know a lot of Canadian skaters and their programs are considered too cheesy, too naive, too shallow, too simple, and unsophisticated. Yet I am often moved by this trust they seem to place in others and almost covet it, for it takes a generous and kind people to allow this sense of safety, so that one can lay bare one's emotions without the fear of being ridiculed or harmed. I believe art is a bond that connects people. In life we have enough reasons to hide behind each of our armors of pretension. Art is a place where people find refuge to be their true selves. Art demands a certain humility; it demands that you give a piece of you that is completely real. It may not count as high art, but it is real.


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Sonny lies to Kate about the real reason he can't spend the evening with her as he oversees the arrival of Karpov's shipment. At the same time, Lucky is the voice of reason when Sam and Nikolas insist that Jerry must be the person smuggling the counterfeit drugs. Nadine sneaks off after eavesdropping on Matt making a phone call.
While on the other side of town, Spinelli is frustrated over the fact Jason doesn't think he's cut out for field work. Maxie assures Spinelli that he has strengths all his own.
In the meantime, Johnny comforts Lulu about her hallucinations of Logan and tells her it doesn't mean she's going crazy. Johnny and Lulu agree to look after Lourdes while Sal is out of town.
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Big Mistake.... :(
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March 22nd, 2008, 07:31 PM
Chip Wheeler
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Join Date: 07-30-07
Location: Grand Blanc/Michigan
Posts: 723
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Originally Posted by
a.j. hall
Dude what are you talking about??
I know what I did was wrong. But I am not lieing when I say I never stole from a jeep.
It was a rich neighborhood with nice cars. Not lifted jeeps or anything like that.
I have already changed. It was a long time ago. After I found out this happend and it was all going to be fine. I was drivng down dixie late at night and I got pulled over and the cop decided to search my friend. He found something that was stolen or something on him and guess what? My truck got impounded. It was so stupid. I didnt even know. Point is that once I seen something piece of shit asshole pull my truck on to the wrecker(d- bag drove it like a prick to). The guy put it in park and the truck slid back(wheel locked up) and jammed into the pavement. You guys all know how hard that can be on a transmissiona and rear end. But I couldnt do anything about it. After seeing my truck get impounded, that was when it really hit me that it was
time to grow up and start acting like a man
. From then on nothing has ever happend. I hardly speed or anything. Im not lieing at all. When you see your self, your cousin and one of your good friends in the back of a cop car and your truck getting impounded it all really hits. Not gonna lie, I cried like a 10 year old little boy. But it all made me learn a lesson and grow up a lot.
Yes, but growing up and acting like a man isnt talking about how crappy peoples stuff is that you took.
Also, you're not Robin Hood. It doesnt matter what vehicle you broke into or what neighborhood you were in.
Chip Wheeler
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Tyranny (edition 2009)
by Lesley Fairfield
Work details
Tyranny by Lesley Fairfield
No current Talk conversations about this book.
The expression "a picture is worth 1,000 words" aptly describes why this graphic novel about anorexia and bulimia is so powerful. The narrator, Anna, doesn't have to tell readers that she sees herself as fat even at unhealthy low weights; readers see this for themselves in panels where Anna is looking in the mirror — and her appearance doesn't reflect reality. Likewise, when Anna suffers through cycles of starvation, binge eating and purging, readers see the physical toll on her body. Perhaps most powerfully, the medium allows for visual representation of the disorder itself in the character of Tyranny. At one harrowing low point, a panel shows Anna, on her knees, literally carrying the weight of Tyranny on her back. The next panel shows her skeletal figure at 85 pounds. Unflinchingly honest, the book also offers hope as readers see Anna successfully moving through stages of recovery. A recommended read for anyone working with youth. A valuable addition to a classroom library; a class copy could have a note pasted inside about how to get help for readers who recognize themselves as being afflicted with eating disorders. "Tyranny" could also be a teaching tool for not only awareness of eating disorders but in a media-studies unit on the portrayals of women in magazines and other pop-culture works.
Nice, fluid artwork, and eye-catching cover. I enjoyed this story, although it was more of a documentation of experience rather than providing deep insight into why the character was able to make the change.
The cover of this had a cool, edgy look to it, so I picked it up and gave it a look. A graphic novel about a young woman's battle with anorexia? Bound to be powerful. Right?
I was expecting more edge and drama from this this than I ended up getting. It had a light-hearted feel to it, mostly due to the art. The illustrations made it look like this would be aimed at younger kids, almost like it could be in Highlights magazine. There was no subtlety in the art or plot whatsoever. While there were some parts that were sufficiently emotional (such as the eating disorder patients playing on the playground and having fun for the first time in a long while, and Anna collapsing on the sidewalk and being helped by an older woman), overall it just looked...kinda silly.
I would recommend this to younger kids who need to read about something like this, like 5th-8th grade, but the tone wasn't mature enough for older readers. The lack of grit and subtlety on a very serious, life-or-death subject really ruined it for me, and I can't imagine it holding the attention of older teens.
Simple black and white line cartoons capture the terrible struggle between one young woman's desire to live and her personalized desire to be thin, named Tyranny. As Anna begins to move towards being healthy, Tyranny bullies her with internal self-talk that is negative and what must be the inner voice confronting many young women and men today. The battle to live is not without backward steps and pitfalls, but Anna continues to struggle towards her goal. An uplifting read for adolescents struggling with bulimia, binge eating, anorexia nervosa and food addiction.
Fairfield presents the exhausting battle one young woman fights against anorexia, personified at the skeletal "Tyranny".
References to this work on external resources.
Wikipedia in English
Amazon.com Product Description (ISBN 0887769039, Paperback)In Tyranny, brisk, spare text and illustrations that deal head-on with anorexia propel the reader along on Anna's journey as she falls prey to the eating disorder, personified as her tormentor, Tyranny.
The novel starts with a single question: "How did I get here?" The answer lies in the pages that follow, and it's far from simple. Pressured by media, friends, the workplace, personal relationships, and fashion trends, Anna descends into a seemingly unending cycle of misery. And whenever she tries to climb out of the abyss, her own personal demon, Tyranny, is there to push her back in. The contest seems uneven, and it might be except for one thing: Anna's strength of character has given rise to her deadly enemy. Ironically, it is that same strength of character that has the ultimate power to save her from the ravages of Tyranny.
Brilliantly and realistically presented, Tyranny is a must-read for anyone looking for a better understanding of eating disorders and for everyone looking for a compelling page-turner that is truly a story of triumph and hope.
(retrieved from Amazon Thu, 12 Mar 2015 18:05:15 -0400)
In this graphic novel dealing with anorexia, young Anna--pressured by media, friends, the workplace, personal relationships, and fashion trends--descends into a seemingly unending cycle of misery. And whenever she tries to climb out of the abyss, her own personal demon, Tyranny, is there to push her back in. The contest seems uneven, and it might be except for one thing: Anna's strength of character.… (more)
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" Brand: Laura Scott / Type: Boots "
I absolutely love boots and of late I have purchased quite a few pairs! I love catalogues and the ease of paying them back over a few weeks and am a huge fan of Freemans and am a long standing customer of theirs!
Having moved to my own flat clothes and footwear is something that I hadn't bought in a while and I decided late one night and with no reviews on here to write to go mad, online shopping. Sadly for my purse I kept most of what was delivered though to be fair I loved the stuff that turned up...and so did my boyfriend lol.
These boots were actually a pair I ordered 'just to see' them and didn't think that they would be very me! I usually like ankle boots or knee highs and these coming up to my calf...well I didn't know what an earth I'd wear them with...I soon found out mind since they fitted me so nice!
The Boots:
They are a dark and deep even coloured black and basically are fake suede though soft to the touch and very well finished. The heels are small but thin and rubber ended 50mm in total size so not what I would describe as high. They are a firm boot and if you are able to see the photograph on the top of this review page they appear slouchy but those ripples giving off that effect are 'set' and meant to be there. They have long zips to the inner of the boot for ease of getting them on and off and inside they are not cushioned or raised or anything like that.
These boots are simply great. They are pointed though rather heavily so don't pinch my toes. Although not padded inside because the heel is small I find them comfortable enough to wear! They are not waterproof but can withstand splashes and the boots don't 'give' over time.
I have owned and worn these boots for some time now and they still look as good as new cos like I have said they don't 'give' or anything and at £49.00 a pair (sizes from 3-7 and the only half size is 6 and a half) they are classsy hard wearing boot that I love and love great with three quarter trousers, skinny jeans and leggings!
Laura Scott / Ladies Boots.


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Take a look at this discussion from the previous sale
4 Star Amazon Reviews
[MOD EDIT: YouTube video removed by user]
TONS of solid reviews (4.0 out of 5.0) over at diapers.com
A couple of OK reviews 93.3 out of 5.0) over at toysrus.com
We got this a few sales ago and love it. We haven't had any issues at all.
Wooted this a while back. Daughter uses it all the time.
I see a few posters saying their kids use it. So why does it look like an accident waiting to happen to me?
I bought this for my son who is 1 1/2. He loves it. We've had no complaints as he bounces all day. Thanks woot!
DrHardcrab wrote:I see a few posters saying their kids use it. So why does it look like an accident waiting to happen to me?
It's intended for kids not adults or even near adults or even adults who act like kids. They hold the bar and jump up and down, Olympic tryouts should be dealt with using parental supervision.
I purchased one triangular shaped but similar in other aspects in 2008. It's been used by many children and still is in use.
No accidents ever, just kids having fun and some physical fitness.
Because you're overprotective? When I was a kid, trampolines didn't have nets and I didn't know anyone who got hurt, other than pride. Accidents happen. Let a kid get hurt once in a while... there's no better way to learn what to NOT do next time.
That said, we've had this for a couple years. No safety issues other than the kiddos fighting about whose turn it is. The middle did get a bit saggy after a while, but that's after A LOT of jumping. Great for those cold winter months when going outside to burn off all that youth fueled energy just isn't going to happen.
Like others, I got this a few sales ago and it was a great purchase. My daughter still loves it and the only issue we have to deal with is reminding kids one at a time.
My daughter has hurt herself falling off steps yet somehow hasn't had an accident on this - even though she doesn't even hold on all of the time.
Would this work for 6 and 7 year-old girls? They're about 45 lbs each. They have a 5 year-old brother, too.
mrsriv wrote:Would this work for 6 and 7 year-old girls? They're about 45 lbs each. They have a 5 year-old brother, too.
80lb weight limit
We bought this a few sales ago and it's always a huge hit with our daughter and guest's kids. My 33 lb 2.5 year old uses it almost every day and it's great for those nights when I really need her to burn off some extra energy before bed. Sometimes if she's really wild on it the back feet lift a little, but it's not like she can tip it. I either tell her to calm down a bit or put my foot on it to keep it down. It doesn't have springs, just a long bungee that needs to be tightened periodically. I've had two toddlers jump on it at the same time with no problem. My friends 6 year old loves it. My only complaint is that it's a pain to store. The bar is removable but only for purposes of packaging it in a flat box.
P.S. My husband said it was kind of a pain to assemble, so heads up on that.
I have the version that the legs come out and fold.. Although this thing is awesome and my 3 year old loves it, not having the ability to slide it under the couch or bed for storage is a bummer.
This might be just what my son with autism needs. We have an outside trampoline but when it's too hot outside he could really use this. Luckily he's on the skinny side so it should last him a couple years.


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Neo-cons move on but the tough stance stays
Page Tools
New job ... Paul Wolfowitz watches US troops train Iraqi security forces.
Photo: Reuters
Recent appointments raise questions about US policy, writes Michael Gawenda in Washington.
As George Bush and Condoleezza Rice flew to Rome for the Pope's funeral, John Bolton, their choice as the next US ambassador to the United Nations, had more earthly political issues on his mind.
Bolton is at the centre of a fierce debate over the direction of US foreign policy, with even some moderate Republicans openly questioning his nomination.
Bolton, the undersecretary of state for arms control, is the most militant unilateralist and the most outspoken critic of the UN in the Administration.
His confirmation hearing before the Senate foreign relations committee was due to be held this week, but was delayed for a week when the Pope died.
More than any other Bush second-term appointment - even more than the nomination of Paul Wolfowitz as president of the World Bank - the choice of Bolton has reignited debate about whether the Administration's apparent attempt to woo disaffected allies and develop a more multilateralist foreign policy has been anything more than a PR exercise empty of any real substance.
Last week 62 former US diplomats and State Department officials wrote to the foreign relations committee urging it to reject the Bolton nomination.
Several days later the committee received another letter, signed by 64 former arms control experts and diplomats, saying the attack on Bolton was really an attack on Bush's policies.
And hundreds of thousands of dollars are being spent by pro- and anti-Bolton groups on television ads, backed up by phone and mail campaigns.
Given that the committee has 10 Republicans and eight Democrats, if one Republican senator voted the "wrong" way, the nomination would be shot down.
Were this to happen, it would represent Bush's first big foreign policy defeat and would enrage Bolton's supporters in the conservative Washington think tanks who are already concerned at some of the foreign policy decisions made in recent weeks.
A defeat for Bush on the Bolton nomination would be particularly damaging at a time when polls show he has the lowest approval rating of a recently elected second-term president, 45 per cent.
Only 35 per cent of Americans believe the country is heading in the right direction, and only 41 per cent approve of the way the Administration is handling the economy - the lowest rating of Bush's presidency.
The polls showed that Americans overwhelmingly rejected the intervention by Bush and senior Republicans in the Terri Schiavo case, and it is only on foreign policy and keeping the country safe from terrorism that Bush retains majority approval.
But what exactly is the Administration's foreign policy, given that some of the key architects of not only the war in Iraq but also of unilateralism, pre-emption and regime change have been moved out of senior roles in the Pentagon and the State Department?
With Wolfowitz packed off to the World Bank, with Douglas Feith, the undersecretary of defence for policy, about to retire, with Richard Perle no longer chairman of the Pentagon's defence policy board and with Bolton, one way or another, out of the State Department, it would seem that the neo-conservatives have had their 15 minutes of fame.
Condoleezza Rice, since her appointment as Secretary of State, has spent most of her time travelling the world in an attempt to smooth relations with US allies that were fractured by the Iraq war.
She resisted pressure to appoint Bolton as her deputy. Instead she opted for Robert Zoellick, the former US trade representative who was the chief US negotiator of the free trade agreement with Australia and who is a veteran diplomat and a supporter of multilateral institutions including the UN.
Wolfowitz and Feith have been replaced at the Pentagon by non-ideological, pragmatic officials. Gordon England is a former navy secretary and Eric Edelman, at present ambassador to Turkey, worked for the State Department under Bill Clinton.
While Rice has publicly supported Bolton's nomination to the UN post, her praise of him has been less than effusive.
Asked recently what Bolton's nomination said about the US's attitude to the UN, she replied: "He's a really good negotiator. He has his ideas about the United Nations but he also knows that the US is completely committed."
There have been other signs that the power and influence of the neo-conservatives - that small cabal of intellectuals and second-tier officials who many observers, especially in Europe, believe captured US foreign policy in Bush's first term - is on the wane.
Three weeks ago, having totally opposed offering Iran any inducements to drop its uranium enrichment program, Bush relented and agreed to allow European Union negotiators to offer Tehran spare parts for its ageing civilian aircraft and support for its membership of the World Trade Organisation.
In some conservative circles this was seen as a serious retreat. The Administration had previously made it clear that its goal was not just to get Iran to abandon its uranium program but also to engineer regime change.
And last week the US, which is hostile to the International Criminal Court, and refused to join it, did not veto a UN Security Council resolution authorising the court to try alleged Sudanese war criminals.
There has been endless debate among Washington insiders about the demise or otherwise of the neo-conservatives.
When Bush in his inaugural address talked about a foreign policy based on the spread of democracy and liberty, the neo-conservatives were said to be in the ascendancy.
When Bush seemed to move away from a policy of regime change for Iran the neo-conservatives were said to be fatally wounded.
Ivo Daalder, a senior fellow at the Brookings Institution - one of the few think tanks not ideologically committed - says the neo-conservatives' influence was always exaggerated.
The drivers of foreign policy in the Bush Administration, he says, have always been Bush himself, the Vice-President, Dick Cheney, the Defence Secretary, Donald Rumsfeld, and Rice. They are neither neo-conservatives nor so-called "realists".
"They are nationalists, and the nationalist direction of the Administration's foreign policy was set long ago by the President and he hasn't swerved from it since," Daalder says.
"The nationalist direction is clear: America is a great power that exists to do great things. America will use international institutions and abide by international law when they advance its great mission.
"But it will abandon institutions and ignore international laws if they constrain its freedom to act."
The new posts for Bolton and Wolfowitz, if Daalder is right, say more about how the Administration sees those institutions than about whether the neo-conservatives are out of favour.
After all the speculation and tea-leaves reading, Cheney remains the most powerful foreign policy official in the Administration, Rumsfeld is still in charge at the Pentagon, Rice is an iron fist in a velvet glove, and Bush is still the President of the world's only superpower.
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Jakob Battick & Friends- "Live at Hogfarm Studios"
(ME-based experimental folk-rooted stuff. For fans of: Gregor Samsa, Low, Red House Painters, The Swans, Nick Cave & The Bad Seeds, Neutral Milk Hotel, Tindersticks, The Veils)
"Jakob Battick & Friends won last month's Deli band of the month, and for very good reason. The young artist along with his rotating cast of musicians are sonically pushing things in their hometown of Portland in the most delicately powerful way possible. Jakob mixes folk and atmospheric elements in the style of Current 93, but brings a unique and more diverse edge to the stage that carves their sound out to stand wholly on it's own." (Will Ryan, Deli Magazine New England)
"And hand in hand, on the edge of the sand, they danced by the light of the moon"
i been feeling this band called mumford and sons, its intense folky acoustic shit.
That Jakob Battick shit is sick man....
CocoRosies comin hard with a new album...
shit aint hittin stores till may...
but i got it for yall...
ill post a link as soon as i figure out how to upload it....
enjoy these in the mean time!
One AM Radio
Rio En Medio- Bride of Dynamite
Rio en medio- i see the star
Anyone looking forward to the new Broken Social Scene album 'Forgiveness Rock Record'? Hits stores May 3rd, I believe. I'll be purchasing that the day of.
Last edited by William Fitzsimmons; 04-15-2010 at 06:01 PM.
been bumpin the new crystal castles and run dmt a lot
see you space cowboy...
Gregory and the Hawk
Damn this thread is dead as fuck.....
what the fuck man....
WE were promised jetpacks
কে ইতালিক জাতির লোকেরা ইতালীয় উপদ্বীপে ভাষাটি নিয়ে
অন্যান্য কিছু ভাষা মি
I Thought I Heard You I Sensed Your Heartbeat, I Was Wrong You Have No Heart.
Listen to
crystal castles-empathy
the xx-heart skipped a beat
metric-collect call
Last edited by Punx; 05-28-2010 at 08:45 AM. Reason: ?!?!?!??!??!!??!!
MGMT- congradulations
You've got the love (XX Remix)
*Original is by - Florence & The Machine
if you want to check out my tumbler: http://errys.tumblr.com/
Elizabeth & the Catapult - Taller Children
sample: http://www.youtube.com/watch?v=UNJmRO4nyG8
Pinback- Blue Screen Life
sample: http://www.youtube.com/watch?v=FMccGgs02Ak
Cocorosie- Grey Oceans
Last edited by boodah; 06-15-2010 at 09:09 PM.
fucking DEERHUNTER has anyone heard of em?
She & Him- Volume 1
She & Him- Volume 2
after listening to weinland i started to really appreciate folk music
Johnny Flynn & The Sussex Wit- Sweet William EP
Johnny Flynn & The Sussex Wit- A Larum


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Arterial blood workshop
Foundation Year doctors will be teaching medical students how to sample arterial blood as well as how to interpret results during a workshop to be held on Tuesday and Wednesday from 4 to 7pm at Mater Dei Hospital lecture rooms 4 and 5.
The workshop, organised by the Malta Medical Students Association, aims to ensure that medical students understand and are familiar with the reasons and correct technique for conducting this test.
See our Comments Policy Comments are submitted under the express understanding and condition that the editor may, and is authorised to, disclose any/all of the above personal information to any person or entity requesting the information for the purposes of legal action on grounds that such person or entity is aggrieved by any comment so submitted. Please allow some time for your comment to be moderated.


text:
"It is always the same. Everybody knows the culture
of the game we want to play and when we don't win it is the
first thing criticised. But we just want to play our game better.
We want to find the right balance between possession and
Arsène Wenger on the vindication of his football philosophy at Old Trafford
Arsène Wenger spoke to Arsenal TV Online ahead of the home game with Sheffield United. It was the end of a busy week for the Arsenal manager. He discussed:
- the breakthrough victory over Man United
- the importance of the game for Emmanuel Adebayor
- sticking with 4-5-1
- Sheffield United
- Neil Warnock
- the possibility of another side which sits back
Subscribers can now see this video footage. If you don't subscribe to TV Online, click on the red button on the gold Arsenal TV Online panel.
12/1 - Arsenal v Sheffield United: Fabregas to score the first goal
Copyright 2017 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source


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Propane shortage looms as temperatures drop
COLUMBUS, Ohio (WTVN) -- There's a shortage of propane in Ohio and the reason is being called a "perfect storm."
Wet conditions in the northwestern United States caused large supplies of propane normally held in the Midwest to be shipped there to help dry out crops. Couple that with a colder than usual winter leading to increased usage, a pipeline that ships propane to Ohio being down for repairs, and the price of U.S. propane being cheaper than world market prices.
"At the moment there appears to be plenty of propane in the country, it's just in the wrong place," said David Field, executive vice president of the Ohio Propane Gas Association.
Ohio Governor John Kasich issued a state of emergency over the weekend to allow extended hours for truckers bringing propane in to the state. It's not just an Ohio problem. The federal government has issued a similar waiver throughout the Great Lakes Region which includes 10 states.
Many propane marketers are urging customers to conserve the propane they have until the issue is resolved.
"Obviously there isn't enough propane at the moment to fill everyone's tank all at once," Field said. "I think we're going to have this under control. I don't know how long it will be."
As with any products, when demand out-paces supply it impacts the price. Field wasn't able to give an average price for propane, but he says there's no doubt that it has gone up and quickly recently.
The good news is that while there is a shortage there are no reports of outages. Field says if you need propane you can probably still get it.
"I don't think there is anyone that is going to go cold," he said.
(Photo courtesy Getty Images)