text:
Two millennia on, Rome celebrates legacy of Emperor Augustus
By Philip Pullella
ROME (Reuters) - Rome, a city that thinks in millennia, is going through a bout of "Augustus fever" to mark the 2,000th anniversary of the death of its first emperor, who left his mark on Rome and Western civilization like few others.
The Eternal City is staging shows, exhibitions, debates and seminars on Augustus, who died on August 19, 14 AD at the age of 75 after a 41-year reign that was the longest in Roman history.
The celebrations will also explore the dark side of a legacy that inspired modern-day dictators, including Italy's own Benito Mussolini, who followed Augustus in using monumental architecture as propaganda to buttress their rule and studied his techniques of gaining, consolidating and masking power.
Augustus vastly expanded the Roman Empire, established a period of relative peace known as the "Pax Romana" and sponsored an explosion of creativity and innovation in architecture, law and literature whose effects were felt far beyond the capital.
He also made Rome a world-class city with infrastructure projects that vastly improved its livability after the discord and violence that marred the preceding period of the Republic.
"The peace he brought meant that a lot of the longstanding problems could be resolved and one of the first ones he tried to resolve was the city of Rome itself," said Valerie Higgins, program director of archaeology and classics at the American University of Rome.
On his deathbed, according to the historian Suetonius, Augustus said: "Marmoream relinquo, quam latericiam accepi" (I found Rome a city of bricks and left it a city of marble).
Monuments that endure to this day, including the Forum of Augustus, the Pantheon, the Theatre of Marcellus, aqueducts and his own massive family tomb were either built on his direct orders or were financed or encouraged by him. Continued...


text:
Ask Health Experts and Get Answers to Your Health Question ASAP
The views expressed by me are for educational purposes only and do not establish a doctor patient relationship.
Hi there,
I am Mysticdoc, experienced Internal Medicine Specialist.
I am here to help you with your concerns.
Since you can feel this equally both sides, this should be part of the muscle.
Muscle fibers can hypertrophy from exercises and can pop up like this.
Not likely lymph node as this will not be felt like this and symmetrically.
that is a new tool JA has started to provide comprehensive care
yes recently
soreness expected after starting exercise
since you did not lift for 2 weeks
yes probably related to that
that is reassuring.
yes understand
not likely
nodes are small.
yes --but do not worry

subset: commoncrawl


text:
Click for "Microbes After Hours" videos
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(13.1 MB, 14.25 minutes)
Show notes:
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Click on a thumbnail to go to Google Books.
The Mistake (edition 2012)
by Wendy James
Work details
The mistake by Wendy James
No current Talk conversations about this book.
No likeable characters but a fascinating plot - not quite a thriller but an unexpected ending.
trying to write from three viewpoints, past and present made the narrative disjointed.
This is another fascinating read from Australian author Wendy James. (I read WHERE HAVE YOU BEEN? last year).
Jodie Garrow kept a secret about her first baby, Elsa Mary, for twenty four years. When her teenage daughter Hannah breaks her leg on a school excursion she is hospitalised by chance at the very hospital where Jodie gave birth to her first child. Hannah shares a genetic characteristic with the earlier baby, and by chance a nurse at the hospital recognises this and then recognises Jodie. Thus begins the chain of events that leads to the investigation of what happened to baby Elsa Mary Evans.
Wendy James really enables the reader to see events from Jodie's point of view. When the hospital nurse searches the records for Elsa Mary's birth certificate and fails to find it, she notifies the authorities and then it becomes a police matter. Jodie and her husband take the step of publicly searching for the baby and so Jodie's story becomes public knowledge. What happens to Jodie and her family is frequently compared to what happened in real life to Lindy Chamberlain in the disappearance of Azaria.
As I said earlier, a fascinating read, well worth your attention.
The Mistake follows the life of Jodie Garrow, a woman who is living the life of her dreams. It's a life she has carefully constructed, built up from her childhood dreams. Her husband, Angus, is an old-moneyed, good looking lawyer with political aspirations. Her children Hannah and Tom are thriving in expensive, high performing schools. Jodie lives in a good neighbourhood, in a nice home, with good supportive friends and does regular charity work. She has all she ever wanted. But Jodie has a secret in her past that no one in her perfect family knows about, and its impending revelation threatens everything Jodie holds dear.
The Mistake is a super-fast, engaging read that has the intensity of a thriller, with the compelling psychological complexity and deep thematics of literary fiction. Jodie's development is subtle, moving between an internal and external perspective that contrasts Jodie's slick, calm demeanour with her inner turmoil. The book mingles reflection and memory with perception and superficial judgement. Initially Jodie's calm has a similar effect on the reader as it does on the narrative public – it distances us. However, as the story progresses, we learn more and more of Jodie's unhappy upbringing – her unloving mother and missing father:
All Jodie wants, all she has ever wanted, is a life without grubbiness, without chaos, a life that follows a clear trajectory of progress, of achievement. Surely, she thinks, it isn't that much to ask. (187)
There are plenty of villains in the story. The most pervasive is Angus himself, with his easy, privileged infidelities, though he does begin to grow a little through his panic attacks, fear and pain. A less complex villain is Angus' hideously snobby mother, who achieves an unambiguously Dickensian unpleasantness, Jodie's false friends are also antagonists who begin to creep away when her secret becomes public. The biggest villain however is the general public that is quick to judge, and takes such great Schadenfreude in Jodie's misfortunes. The story pivots on these antagonists, and brings in a broader philosophical perspective about the role of the media and the public's hunger for voyeurism:
She can see now how it happens, to the Amy Winehouses, the Heath Ledgers, the Michael Jacksons – can understand why they seek the solace of drugs or alcohol or risky behaviour. Perhaps it makes no difference, really, whether they're feted or maligned, adored or abhored – either way, they're endlessly exposed their every action scrutinised discussed, critiqued. They're like butterflies trapped under glass, microbes under a less than benign microscope. Separate. Isolated. Utterly alone. (202)
Jodie doesn't get off lightly – she has to pay her dues, as, to a lesser extent, does Hannah. But in the dramatic irony of their growth, there is a strong development and self-realisation, particularly for Jodie. The Mistake is about far more than a single mistake. It's also about our choices and the flimsiness of the lives we build around ourselves- the many trappings, roles, compromises, and illusions. Though the novel reads easily and won't be easily left until the full truth of Jodie's story is revealed, this is no comfortable beach read. There's a depth to the theme and a richness in the characterisation that will stay with the reader. The power of friendship too, to winkle out truth and deeper meaning in life, is one that provides some redemption to Jodie's story, though the powerful ending still comes as a shock.
The Mistake is an expertly written, compulsively readable novel that repays the reading with rich reflection. There are no easy answers here and the multiple 'truths' of the novel are continually called into question. Everyone is culpable. There are plenty of parallels between Jodie Garrow's life and those of other real-life women who have been caught up in a media frenzy and judged based on appearance. Nevertheless the psychological implications go beyond a political statement. This is a powerful book with broad appeal.
This book is centred around the character of Jodie Garrow born on the wrong side of the tracks who becomes pregnant after a one night stand at a very young age. With no one in her family to support her and not wanting to keep the baby she goes to a small hospital where, with the help of the matron, she has the baby illegally adopted and tells no one. She then carries on with her life , marries lawyer Angus and has two children. Her life seems to be going well and she has all she wants until an unexpected visit to the hospital where the birth took place brings her face to face with her past, and the adoption is brought to the attention of the authorities who want to know what has happened to the baby and where she is now. When there seems to be no trace of the baby the media are all to quick to consider that Jodie may have in fact killed her. The narrative moves between the past as Jodie recounts the events surrounding the birth, and the present where we see the profound effect this event has on the lives of her husband and her daughter Hannah. The mystery element of the story kept me really interested. I really enjoyed this book and would recommend it as a good one to read.
I still remember the profound sense of disquiet that WHERE HAVE YOU BEEN? left me with, and Wendy James has done it again with THE MISTAKE.
There's something about Jodie Garrow that I suspect is going to trigger differing responses in readers. Personally I couldn't get past a very obvious sense of Stepford Wife syndrome. She's a socialite, immaculately made-up, coiffured, dressed to the part of the wealthy wife of a high profile husband. There's the perfect family - a boy, a girl, a modern house. She's a big fish in a very small pond - a metaphor that extends as the plot of the book expands and, in Jodie's eyes, she's increasingly surrounded by the sharks - media, friends, mother-in-law. Even the supportive, but ultimately unfaithful husband. There's obviously a lot wrong in Jodie's life and it seems that the revelation of the illegal adoption all those years ago has suddenly bought all that's bad to the surface.
It's also distinctly possible that Jodie is everything that's wrong in Jodie's life, and this author has done a particularly good job at confusing that possibility. Is Jodie the ultimate unreliable narrator, or is the media frenzy, the trial by public opinion, more what is going very very wrong in this woman's life? Why has she stepped back, wrapped herself in what seems oddly passive acceptance, why doesn't that quite stack up against the revelations of Jodie's background and her determination in other areas of her life? Add a philandering husband who does seems to be stepping up to help, a rebellious teenage daughter, and there are cracks in this perfect life that widen with every page.
The point of view moves around between Jodie, her husband Angus and sixteen-year-old daughter Hannah. The timeframe also changes between the present and 1986 when the missing baby was born. The main voice however is always Jodie. As everybody else reacts and deals with the circumstances, Jodie alone knows the full story of what happened to baby Else Mary. Yet somehow her story doesn't quite ring true - whether or not that's because the media hype is winning, or whether or not there is something wrong in what Jodie is saying is not all that easy to decide.
It was hard not to be struck by the coincidence of finishing THE MISTAKE just as a Northern Territory coroner declared that a dingo did indeed take baby Azaria Chamberlain. Hard not to think of the hysterical media and public speculation that went on around that case, hard not to consider the mindless obsession with looks, clothes, demeanour.
In THE MISTAKE, once again, James takes the reader into some very interesting territory. The book is definitely almost pitch perfect psychological thriller, and it's going to be very discomforting reading for some people. It's sneakily challenging, disconcerting, compelling, car crash fascinating, and probably one of the best fictional reminders I've had in a while that public and media opinion should never be mistaken for the justice system, regardless of the ultimate outcome.
References to this work on external resources.
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We all have secrets... Jodie Garrow is a teenager from the wrong side of the tracks when she falls pregnant. Scared, alone and desperate to make something of her life, she adopts out the baby illegally -- and tells nobody. Twenty-five years on, Jodie has built a new life and a new family. But when a chance meeting brings the adoption to the notice of the authorities, Jodie becomes caught in a nation-wide police investigation, and the centre of a media witch-hunt. What happened to Jody's baby? And where is she now? -- Cover.… (more)
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Penguin Australia
An edition of this book was published by Penguin Australia.


text:
Sexy Student and His Wanting Teacher" Sexy Student and His Wanting Teacher">Sexy Student and His Wanting Teacher Jayanfire
11/07/2007 email@example.com First thanks to the KERALA EROTICA and its team for publishing this. This is my first story in this great site and I am sure I will add more. This story is not fully true incident but have many parts extracted from my life. I am jayan (name changed) and she Sujaya (name changed).Lets introduce me first. At that time I am studying in 12th in a CBSE school in Ernakulam .I am not very so built but you would like me in one way or the other. I am a student who wants to have sex with every beautiful girl I sees even though I had no chances to have sex with any girls and I deeply wants one. Sujaya was my English teacher in 11th as well as in 12th . She is about 30 unmarried. She had medium complexed colour and she had long hair and I really loved girls having long hair Even though she is not beautiful by her face she is so sexy with her belly and her boobs.She had a beautiful mole in her belly. I in my 11th I did not notice her boobs and belly much but only made glances over her. She was really adorable and the way she dressed and walked one could see her sweet belly and more than half her boobs and if tried hard one could see her washer. In 12th I became more attracted to her and would always want to look at her and I could have glances of her boobs and belly many a times. I became little friendly to her so that I could have little more freedom in class and to look on her. I never had a hint that she noticed my looks on her as she behaved to me always in the same way. The feeling in me was aroused and I really wanted to have a look and touch at her whole body. Even though I looked at her regularly during the class she did not notice it. I always wanted to have a call for sex on her but you know as I am her student I can't make it. I even would ring in to her mobile and would keep quite when she would attend it to hear her voice. This went for a long time. But I wanted more of her. One day she noticed that I was looking at her and she became furious to see where all I was looking. I didn't see it but I have always thought that she also wanted to have sex with someone. She noticed that I was mad on her and she during next day's period came closer to me so that I could have a better glance on her. I really enjoyed during that days class. Then came the series of exams and I at home in front of books would think of my sweet teacher. When I and my friends went to collect our answer sheet of English exam she said she wanted to tell something to me about my studies and asked my friends to go. It was a free period for her and nobody other than me and her where in the room. She told to me that I was not concentrating on the period and always looking at somewhere else. I thought that she did not mean my looking's on her and said that I was listening to her in the class (As I would have reasonable marks I could tell that lie). Then I asked her where all I has to improve in my answers of letters and notemakings.All this time I could see her washer because she had freed her saree willingly. I glanced at her frequently and was becoming out of control. She noticed my shaft erect and she asked me to contact her whenever I had any doubt. One Saturday night I called her and asked her some doubts in letter making and in note making. She told me it would not be possible to describe in phone and asked me to come tomorrow morning to her house so that she could clear my doubts. I agreed and said I would come to her house by 9 am. I thought that I could go to my friend's house after clearing the doubts. Next day I reached at her house and there was no other people as her father and mother had left for marriage of their relative in kottayam early in the morning .I was in shirt and jeans and she in saree.I could see her belly and boobs easily as her saree was so free as every woman would do in her house. We sat at her room and she started clearing my doubts .After some teachings she went in to her kitchen to make two cups of tea for some refreshment. Many sexy thoughts flashed thru my mind. I noticed the sexy books under some books in the room. I also noticed a book on letter making underneath these books and when she returned I told her that I want some reference books to take to home and she gave him some. I said that I would take it when returning from my friends house then she jokingly asked me whether I am going to any girlfriend's house. I with a sexy smile said no. We chatted for some time. Then our talking went in to love making to romance and finally to sex.She asked me whether I had any relationships with any girls and I truly said no. Then she said she had noticed my moments and looks in the class and I confessed that I hadn't seen a nice belly and boobs not even in BF and so I always look at hers. Then she asked me whether I want to touch her and have sex with her and I agreed to it. I said that first I wanted to look at her as I look her in the class. After some time I went near her and made her lie on bed and touched her soft belly and it felt so soft. I put my face in to her belly and felt her washers with my face and I put my tongue in to her washer. It was so nice. Then I bite and licked her ears and neck for some time. (I am a passionate lover of foreplay).Then she put her hand inside my shirt and felt my chest with her hands and she undid my shirt buttons and rolled her tongue all thru my chest. She smelled really adorable with her boby odor. Then we decided to have a French kiss and I asked her to close her eyes and placed my lips so close to her but it didn't touch hers. My hot air flowing in to her face and she became restless and hold my head tight on her hand and forced me to kiss her. I should tell you that it was as you tasted the sweetest icecream.She was really hot and my fore play had really aroused her more. Then I put my tongue deep in to her mouth. It went on for about 10 mins and then I took out her saree and felt her boobs.Oh! It was really so spongy. Then I went under to her leg and licked her legs with my tongue. Then I moved upward and rubbed my face with her thigh. Once again I went up to her boobs and played it. Then I unhooked her blouse and I saw one of the best boobs in the world. Then she once again rolled her tongue on my chest and then unhooked my pants and felt my thighs with her face and I took out her petticoat and rubbed her pussy with my hands for some time. Then I got her bra unhooked and I put her right boobs on my mouth and sucked it. She closed her eyes and I was sure she was really enjoying it and she brushed thru my hair. After it I changed the boobs and hold the right on my hands and pressed it. She made some sweet sounds which made me further encouraging. Then after sucking her boobs for over 20 mins I went down and took out her panties.Oh!The woman I used to dream of is now nude in front of me. It was beautiful pink coloured she had little hair but shaped which invited me to suck and fuck.I put my hands on to her pussy and it was so hard to enter two fingers but was so nice. I was sure by that she was a virgin and I licked her pussy with my mouth and she made sounds due to pain and the joy and at last she cummed on my mouth.It was little sour but it for me was like honey.She then holded my shaft under my briefs which was so overjoyed and for me it was like some electricity passed thru me. Then she took out my briefs and started sucking my shaft. She sucked on its head as well as deep in to the shaft and under the balls. She licked every in my shaft and under my shaft in the thighs. She put all my shaft and she made me move as you move your shaft in pussy. It went for about 7 mins and I said to her that I was about to cum.Then again I started sucking her boobs but her pussy always invited me to lick rather than to suck her boobs so I once again licked her pussy and now with more pressure and she aroused some noises due to the pain and enjoyment. I licked and bited her lips with maximum joy. After 10mins we decided to loose virginity and we went on our knees and I pushed my shaft in to her from behind her and placing one had on her boobs and rubbing her pussy with the other one. I slowly tried to penetrate my shaft deep in to her wet pussy and then I increased the frequency slowly and she produced sounds like Ahhh! Ohhhh! Etc. Which made me to fuck her harder and I first fucked in and out then to arouse her I fucked in a circular way. It was really trilling experience for both of us. I fucked her until I was feeling like Cumming and took it out and went straight in to her boobs and sucked it for another 10 mins.During it she pulled my hair very hard. I was both in pain and ecstasy then I stretched my legs and opened it widely and allowed her to put her pussy on my pennies all by her and at this position I could suck her boobs as well as fuck her. We continued in this position for some 10 mins and when I felt like Cumming she took my shaft on her mouth and sucked it until I cummed in her mouth. After that we had a bath jointly and I applied soap all over her body and in her boobs and she applied soap on me and my shaft. After that we exchanged some kisses and came out of bath and had lunch together and after lunch we slept for over an hour nudely and then I took some ice cream and applied it on her boobs and licked it without wasting a drop. The cold ice cream melted in no time as she was so hot. All thru the sessions we were very dedicated and open to each other and it made us possible to have a good foreplay and good sex.After that I left her house with full stomach filled with her grand fest. GOOD DEDICATION, OPENNESS, and FOREPLAY are needed for true sex. I appreciate both male and female readers and you can send your comments and Suggestions regarding this so that I can improve in my second experience/story. Women wanting for friendship/sex/love sent can contact me at firstname.lastname@example.com Once again THANKS TO KERALA EROTICA FOR PUBLISHING
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text: Photos (1) Map and Directions Street View Commute Time Walk Score Driving Walking Transit Get Directions Close No driving directions were found. Please adjust your search. To: Lot 36 Parkview Crescent, Prince George, BC From: Via: Directions turn left on street 4 minutes 2.5 miles Driving Directions - View this Property Today LOT 36 PARKVIEW CRESCENT - Exciting new subdivision, a total of 62 lots and many with greenbelt. Prices starting from $99,000. Design guidelines available. All lots ready to be built on. Location is key, close to UNBC, good all day sun and connected to the University Heights trail system. Builders terms available, hurry and pick out your lot. Some views of Tabor Mountain. Property Details ID: N236804 Storeys: 0 County: Canada Style: Other New Construction: No Status: Active Lot Area: 1,881.00 Square metres Features Other Fireplace Present - False Transaction Type For sale Listed By Royal LePage Prince George


text:
FIV1 - forced inspiratory volume in 1 second, FIV1%VC
FIV1 is the volume that can be forcefully inhaled in the first second during a forced inspiratory maneuver started from residual volume. The measurement is performed during an FIVC maneuver. Most people find the inspiratory maneuver difficult to perform.
There are no official guidelines (ECCS, ATS, ERS) with regard to the measurement of this index. Analogous to requirements for the FEV1 the following is recommended:
- Report the largest of 3 satisfactory maneuvers.
- Obtain the start of the forced inspiration by extrapolating the steep initial portion of the volume-time recording.
FIV1 is useful in quantifying extrathoracic airway obstruction, and when combined with the FEV1 to assess whether loss of lung elastic recoil contributes to expiratory flow limitation. Normally FIV1 is > 80% IVC (ref. 1).
Ref. 1 - Reference values for FIV1
Tammeling GJ. Standard values for lung volumes and ventilatory capacity of sanatorium patients. Selected Papers. Royal Neth Tuberc Ass 1961; 1: 65-89.


text:
Rockport Music presents: National Theatre Live in HD: The Magistrate
7 Pm Thu, Jan 17, 2013
Venue: Shalin Liu Performance Center
37 Main Street, Rockport, MA 01966Contact:
Rockport Music
0 people saved this
Academy Award nominee and Tony Award-winner John Lithgow (Dirty Rotten Scoundrels, Shrek, 3rd Rock from the Sun) takes the title role in Arthur Wing Pinero's uproarious Victorian farce, directed by Olivier Award-winner Timothy Sheader, in a production sure to have audiences doubled up with laughter. When amiable magistrate Posket (John Lithgow) marries Agatha (Olivier Award-winner Nancy Carroll, After the Dance), little does he realize she's dropped five years from her age - and her son's. When her deception looks set to be revealed, it sparks a series of hilarious indignities and outrageous mishaps.
What to Expect From Sail Boston 2017
The Tall Ships will soon make their way to historic Boston Harbor. Here's a look...
Search All Listings Here.


text:
Outdoor Routed & Sandblasted Signage transforms regular exterior signage into beautiful works of art!
Virtually all companies and organizations strive to achieve a distinct style or brand. Custom routed and sandblasted wood signs provides just that. Unlike traditional monument and building signage, outdoor routed and sandblasted wood signage provides a dual tone and rustic look that is befitting of many businesses.
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For a FREE quote on a outdoor routed and sandblasted wood signage package contact your local Signs By Tomorrow.
To speak with a Signs By Tomorrow professional in the Signs By Tomorrow, MD area contact us.


text: I am curious what people think of the feasibility of this for mac and iOS screen inverting behavior. I believe this could be very easily pulled off by low level code. I would love it it it was 1st party supported by apple. I did this in photoshop very quickly, by adding a layer above the existing screenshot, inverting it and turning the mode to luminosity. As I understand it, it should change the value (light/dark) information but not do anything to hue/color. People look to hue information to understand what objects are and we don't have a great abilities with which to anticipate inverted RGB hues. So with this, an inverted pumpkin image would still be orange-ish. Pinterest logo would be red. The value might be slightly different, but it wouldn't be radically different in terms of hue. What do people think about this? Would this break anything about the normal invert behavior? I tend to invert a lot and this would be great for me, but I would be okay with it being an option only.


text:
Saturday, September 25
Monday, September 20
10th Birthday Party
A really lovely afternoon spent by all.
We ate "powder blue" frosted fairy cakes and meringues,
washed down with a glass of pink lemonade.
washed down with a glass of pink lemonade.
Selina Lake was on hand to sign copies of her book Romantic Style...
Monday, September 6
Book Launch at Powder Blue...
The launch party of Romantic Style, the new book by Selina Lake and Sara Norrman, will be at the fabulous and beautiful Powder Blue boutique in Leicester. The launch is being hosted by Debbie Johnson, who owns the shop and whose gorgeous home and props are featured in the book.
Stylist Selina Lake, the author of Bazaar Style will be there signing copies of the book. This party is extra special as it also celebrates the 10th birthday of Powder Blue so expect plenty of birthday cake and pink lemonade. Yum.
The Launch Party is on Saturday 18th Sept, from 1.30pm onwards.
Address: Powder Blue, 3-5 Francis Street, Stoneygate, Leicester, LE2 2BE.
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text:
SGS742 in Patients With Mild to Moderate Alzheimer's Disease (AD)
This study has been completed.
Saegis Pharmaceuticals
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
First received: October 7, 2004
Last updated: December 10, 2009
Last verified: February 2009
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this trial is to determine the effect of a new drug, SGS742, on memory and cognition in patients with mild to moderate Alzheimer's disease.
|Alzheimer's Disease
|Drug: SGS742
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Masking: Double-Blind
Primary Purpose: Treatment
|Official Title:
|A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Study of the Efficacy and Safety of SGS742 in Subjects With Mild to Moderate Alzheimer's Disease
Resource links provided by NLM:
Genetics Home Reference related topics: Alzheimer disease
MedlinePlus related topics: Alzheimer's DiseaseU.S. FDA Resources
Further study details as provided by National Institute on Aging (NIA):
|Estimated Enrollment:
|Study Start Date:
|April 2004
|Study Completion Date:
|September 2007
|Primary Completion Date:
|September 2007 (Final data collection date for primary outcome measure)
SGS742 is a GABA(B) receptor antagonist. It is an orally active drug and possesses neurochemical and psychopharmacologic features that suggest it could improve memory and cognition in humans. The primary objective of the SGS742 clinical trial will be to determine the effect of SGS742 on memory and cognition in individuals diagnosed with mild to moderate Alzheimer's disease. The duration of the study is 3 months with 5 clinic visits.
|Ages Eligible for Study:
|55 Years to 90 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- 55 to 90 years of age
- Diagnosed with mild to moderate Alzheimer's disease
- Willing caregiver
- In general good health
Exclusion Criteria:
- Call 1-877-MY-MEMORY and ask to be referred to a study center located near you for entry criteria information.
Prohibited Meds:
- Alzheimer's medications (Aricept, Exelon, Remydl, Nemenda)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00093951
Show 59 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00093951
Show 59 Study Locations
Sponsors and Collaborators
Saegis Pharmaceuticals
More Information
Keywords provided by National Institute on Aging (NIA):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on June 26, 2017
|ClinicalTrials.gov Identifier:
|NCT00093951 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 7, 2004
|Last Updated:
|December 10, 2009
Keywords provided by National Institute on Aging (NIA):
Alzheimer disease
GABA(B)receptor antagonist
Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
(3-aminopropyl)(n-butyl)phosphinic acid
Neuroprotective Agents
Protective Agents
Physiological Effects of Drugs
GABA Antagonists
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on June 26, 2017


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Dinner Meeting "Career Night"
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Addressing Your Agile/Scrum Challenges
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are sway bars really going to make a difference?
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Banned User
Join Date: Jul 2012
Location: California
Posts: 61
My Ride: 2004 330ci
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Originally Posted by
I absolutely love the Hotchkis Sway Bars, they are one of the best suspension upgrades I have done (and I have upgraded every single piece of the suspensions on both 328Ci and 325i). I have used them with ST V1, TC Kline D/A, and KW V2 coil-overs, amongst others, and they make a HUGE difference in cornering stability and provide the absolute best bang for the buck of any suspension upgrade. On the 325i, for example, I just had ~$5k worth of parts as well as the full TMS Reinforcement kit installed (all bushings are the stiffest option without being "solid": Rogue Engineering "Blue" RTAB's, UUC "Red" engine mounts and "race" trans mounts w "enforcers", TMS RCA bearings, TMS adjustable rear camber/control arms, Meyle HD + TMS Delrin/Aluminum diff mounts/bushings, PowerFlex 66mm FCAB's and their whole Subframe Bushings kit, Meyle HD FCA's, Rogue Engineering RSM's with welded reinforcement plates, and literally about 70 other parts).
The difference between all those upgraded parts with the sway bars and without is immense, just as on my 328Ci (which is far less streetable; 325i is a DD). I can set the KW V2's to their softest setting and still get ZERO roll in turns yet the ride quality remains good, which is awesome. I do have TMS Adjustable Swaybar Endlinks, but even without them the sways are just awesome.
The Hotchkis are better than the H&R many times over, and I prefer them over the TMS and other kits available. They are just that good. I guarantee you will notice a difference, especially under hard cornering, as you will have much better control over the car due to maintaining a larger contact patch. DO IT!
I was just about to switch out my tms bars for the hotchkis. I'm glad to hear you think that that would be an upgrade.
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Vincent's serves the Greater Marietta area casual dining with their zesty, and flavorful Italian cuisine. Dishes are made from fresh ingredients, and their customer service? Magnifico.
Your taste buds will sing an operatic aria when you partake of their many specialty meals, like their creamy Baked Ziti or enticing Eggplant Parmigiana. Buon Appetito!
Situated in Marietta, Vincent's serves up authentic Italian cuisine and pleasing beverages to tables full of pleased patrons each and every day.
When new offers are available from this business.


text: 07 February 2012 Councils invited to bid to become 'Portas Pilots' The Government is inviting councils to bid for funds to help them turn around the fortunes of 'unloved and unused' high streets. The competition to become one to 12 'Portas Pilots' follows last year's Government commissioned High Street review conducted by retail expert Mary Portas. In it, she claimed town centres should be run like businesses with a much closer focus on retailers' and shoppers' needs. Bidding towns, which could benefit from a share of £1M, will be expected to come up with the best High Street blueprints in a move that fulfils the first and last recommendations of Ms Portas' review. This includes the creation of a 'town team', made up of the key players in their local community - such as the council, local landlords, shopkeepers and the local MP. Areas will have to 'demonstrate how they plan to breathe new life into their high streets and shopping parades, but not just in a staid application form', local government minister Grant Shapps said. He would also like to see councils submit pitches to become Portas Pilots in the form of short YouTube clips. 'Today I'm offering a golden ticket to 12 town centres across the country to become 'Portas Pilots' - areas with the vision and enthusiasm to breathe new life into what should be the beating heart of their communities, and they will get Mary's and my support as they try out the ideas in her recent review,' Mr Shapps said. 'I want to see how these Town Teams plan to try new things, experiment and ensure that their high streets and parades become destinations for local people want to be. But these pilots are just the start. We want to learn their lessons and help communities across the country breathe new life into their own towns. Launching this competition now is a signal of our understanding that there's no time to waste in driving forward these important measures.' Mr Shapps will give the full Government response to the review by the Spring. View the Portas Pilot prosectus here. View more information on these councils


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On Wednesday next week, March 20th, the Financial Services Subcommittee on Financial Institutions and Consumer Credit will hold a hearing on two studies recently completed by the Federal Deposit Insurance Corporation (FDIC), the Federal Deposit Insurance Corporation Inspector General (FDIC IG), and the Government Accountability Office (GAO). The FDIC IG and GAO studies were done in compliance with legislation I drafted that was signed into law in December 2011 (Pub. L. No. 112-88).
The law required the GAO and the FDIC IG to look into fair value accounting and the use of shared loss agreements and whether they contributed to bank failures, and what impact bank failures had on local communities. The states in the study included Georgia, Arizona, California, Florida, Illinois, Michigan, Minnesota, Missouri, Nevada, and Washington. All states have had at least 10 bank failures since 2008. Georgia leads the nation in bank failures, with more than 84 failures since 2008. Many community banks feel the FDIC's practices have actually led to more bank failures, meaning they harmed more than they helped.
Georgia has been very hard hit by the large number of bank failures we have had in our state. Community banks are the economic engine of many of our towns and cities. When they fail, we often see economic investment dry up -- an unmistakable reality proven by the fact that states with the highest number of failures also have some of the highest foreclosure rates and highest unemployment rates in the country. This is not a problem that one study will be able to solve and I will continue to look into the issues behind the vast number of bank failures in Georgia and around the country, but I look forward to questioning the GAO, FDIC, and FDIC IG on their studies to learn more about their findings.
I encourage everyone to TUNE IN and watch the hearing live. You can do that by visiting the Financial Services website and click on the "LIVE WEBCASTS" link on the left side of the page under CONNECT. I will also be LIVE TWEETING the hearing. Find me on Twitter at @RepWestmoreland.
Source: http://westmoreland.house.gov/index.php?option=com_content&view=article&id=797&Itemid=372


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The Puerto Rican native is one of three brothers who are all Major League Baseball catchers (brothers Bengie and José play for the San Francisco Giants and Los Angeles Angels of Anaheim, respectively). Many consider Bengie to be the best offensive player, but Yadier, the youngest of the three brothers, is easily the most valuable – for his amazing, clutch defense.
Molina has been said to have a "cannon" for an arm, and his game-winning pickoffs at first base or his ability to catch runners stealing proves that. Not only can he throw with power, he can throw with accuracy, making him easily one of the top defensive catchers in baseball, even though he has not been properly recognized for it.
So far in just two full seasons with the Cardinals, Molina has thrown out at or around 42% of base runners who have tried to steal on him – a feat unrivaled by most. Molina has played 292 career games behind the plate, and he has only committed 13 errors during that tenure. He has not won a Gold Glove award yet, having been beaten out by former teammate and now retired catcher Mike Matheny in 2005 and Houston Astros catcher Brad Ausmus in 2006.
2006 was the year many believed Molina would win his first Gold Glove award, but Ausmus held a .003 advantage in fielding percentage, pushing Molina into the second spot. Yadier did beat out Ausmus in assists (80 for the Cardinals' catcher while only 63 for Ausmus), but overall, Brad Ausmus had the better numbers in 2006 – but did he have the intangibles?
Nicknamed "Yadi" by teammates and fans, Yadier Molina has become somewhat of a fan favorite in the St. Louis fan base. He was known for making clutch, game-winning plays on defense, which made up for a horrible lack of offense. The fans chose to accept him for who he is, rather than try and push him to become a better offensive player. Luckily, Molina didn't need the fans' support, and his offense really picked up in the playoffs, perhaps foreshadowing a breakout year in 2007.
In the regular season, Molina was less than stellar at the plate, hitting his lowest career average at .216, while compiling only 49 RBIs, 29 runs, and six home runs. Perhaps Yadier's lone bright spot at the plate was his ability to hit for doubles, as he finished with a career high (26) in that area. Molina's batting average floated around .220 all season long, but something was triggered once he reached October, and he instantly became a post-season hero for the Cardinals.
In the 2006 playoffs, Molina played 14 games, and failed to get at least one base hit in only four of those games. Even better than that is the fact that he only failed to get on base in two games. By the time the Cardinals had won the World Series, Yadier had put up these numbers: .358 batting average, a .424 on-base percentage, two home runs, four doubles, eight RBIs, and six walks.
Molina also had his clutch moments, his biggest coming against the Mets in Game Seven of the National League Championship Series when he hit an eventual game-winning two-run home run in the top of the ninth off Mets' pitcher Aaron Heilman. It put the Cardinals up 3-1, which was the final score and sent the Cardinals to the World Series, where Molina would bat 7-for-17, including a 3-for-4, two run performance in the clinching Game Five in St. Louis.
Yadier Molina's spectacular performance in the 2006 playoffs may be a sign of things to come, and if so, Yadier Molina can be one of the best overall catchers in baseball. With former great catchers such as Tom Pagnozzi and Mike Matheny to suit up for the Cardinals, perhaps the one with the greatest potential is Yadier Molina. He was the youngest starting position player on the Cardinals in '06, and at the extremely raw age of 24, he only has room to improve.
There's a decent possibility that Molina will continue swinging a hot bat in the 2007 regular season, but there is always that chance that he will not be able to keep up that pace, especially at such a young age. Besides, Molina's greatest talent is when he's behind the plate, calling pitches, calming pitchers, and throwing out base runners.
As for his backups, it's basically down to Gary Bennett and recently re-signed Eli Marrero. Bennett got to see quite a bit of playing time last year, and really started getting hot behind the plate in August. He hit four homers in one week – one of which was a walk-off grand slam against the Cubs.
As for Marrero, a player the Cardinals' signed to a Minor League deal, he has a chance to make the team, but it is unlikely. If he does, he will have to put on a strong showing in Spring Training, but after Bennett's clutch hitting in '06, barring injury, it is very unlikely Marrero will see much playing time this year.
Overall Position Grade: B
© 2007 stlcardinals.scout.com. All rights reserved. This material may not be published, rewritten or redistributed.


text: I have no clue what subaru part # a rear wiper blade is for a 2005 wrx wagon. Any help would be greatly appreciated as all the replacement wipers will not fit onto the rear wiper assembly. Yes, I checked subarugenuine parts and such could not navigate to find part #. Also, any wiper blade after market companies act as if there are no rear wiper wagon available. I appologize just need to vent.


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Types of Ceramic Tile
Ceramic tile has been used for centuries and offers consumers more options in color, texture, pattern and overall beauty than most other floor covering materials. With today's new manufacturing techniques, ceramic tile designs are virtually indistinguishable from natural marbles, travertines, slates and other stone products. Glazed ceramic tile and porcelain tile are great choices for bathrooms, kitchens, foyers, sun rooms and great rooms thanks to their durability and resistance to water and staining.
With this wealth of options, you can let your imagination go free and express your unique and personal decorating tastes. But with all latest tile fashion trends in colors, sizes and designs including decorative insets and borders available at your fingertips at Kelly's Carpet Omaha, it can be helpful to familiarize yourself with some common tile terms, rating methods, and important differences before you go shopping.
Wall Ceramic Tile
Wall ceramic tiles are normally less durable than tile designed specifically for flooring. Most wall ceramic tile is glazed with a semi-gloss or matte surface. The glazed surface has a very low slip-resistance and becomes slippery when wet. Therefore, glazed wall tile is much more suited for wall or countertop applications rather than floors.
ColorBody™ Porcelain Tile
ColorBody™ Porcelain Tile is the densest of all tile types available on the market today. It has a through-color body and is defined by its <0.5% water absorption. These tiles can withstand the heaviest foot traffic and are well-suitable for both indoor or outdoor applications.
Like natural stones themselves, specific tiles of each individual product will vary in shading. This adds to the beauty and design of the finished tile project. When choosing a tile it's best to view 2-3 tiles together to visually determine the overall appearance of the tile.
Tile Rating Methods
To determine the overall performance and durability of the glazed surface of ceramic tile, there are standardized industry tests and classifications which rate a tile type's specific resistance to scratching, breaking, abrasion, moisture, etc…
Scratch Hardness
Most tiles are rated for hardness or scratch resistance using the MOHS Test and rating system. The MOHS test will rate a tile type from 1 (softest) to 10 (hardest). Ceramic tile with a value of 5 or more is suitable for most residential floor tile applications. Tile with a value of 7 or higher is normally acceptable for most commercial applications or heavy traffic areas.
Wear Rating
To help select suitable tiles for specific applications tiles are rated the P.E.I. (Porcelain Enamel Institute) scale. The tiles are evaluated for wear resistance on a scale from 1 (lowest) to 5 (highest).
- PEI 1: Light Traffic – recommended for residential bathrooms or other areas with light traffic and where shoes are not frequently used.
- PEI 2: Medium Traffic – recommended for residential interiors, except entryways, kitchens, stairs or any area where tiles may come into contact with gravel or sand.
- PEI 3: Medium-heavy Traffic – recommended for all residential interiors and light commercial applications. Not recommended for commercial entryway.
- PEI 4: Heavy Traffic – suitable for all residential interiors and most commercial applications, including shopping malls and public areas.
- PEI 5: Heavy-plus Traffic – all residential and commercial areas where heavy-duty wearability is needed.
Water Absorption
Ceramic tile are also classified by their water absorption rate which reflects the density of the body of the tile. There is a direct relationship between the water absorption rate and the suitability of the various types of tile for interior or exterior applications. Tiles suitable for exterior applications must have a very low water absorption rate, especially in climates subject to freezing and thawing cycles. These are typically porcelain body tiles that have a moisture absorption rating of less than .5 %.


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We love cross over details and we love it even more on mules. With a suede finish and comfy block heel, this is a must have that goes with just about anything. From jeans to dresses, you won't find a look this won't go with!
Upper: Leather
Heel Height: 5cm
Made in Spain


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Into 32 FordCoupe
New to this
Looking at a 32 Ford coupe, want one since I was a kid. Now that I am retired i am going to do it.
Welcome to Hotrodders, Bob! I think you'll like it here and I'm sure we'll enjoy having you. I know I will because at 15 I wanted to buy a '32 chopped and chaneled pick-up that had a 327 with either 6-2 barrels or 2-4s and 4 speed. I had saved enough money ($950) but my parents said NO! Well that was 54 years ago and I have gone a different direction, but I'm still into cars, just in another way as you'll see below.
Yea welcome Bob, I'm building (for a long time now) and I have to say REPLICA '32 F/glass Victoria. You going orig. Henry? Do you have one picked out or just started looking? As you may know '32's are very expensive to build...even if you can do most of the work yourself. Good luck though, the stuff is out there, just have to find it.
32 Ford Coupe
Thanks for the info
I have one I am looking at
32 3 window coupe 350 auto with headers and walker rad
Coil over shocks. Disk brakes and more
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Drug-drug Interaction Study
This study has been completed.
Amicus Therapeutics
Information provided by (Responsible Party):
Amicus Therapeutics
ClinicalTrials.gov Identifier:
First received: June 23, 2011
Last updated: December 5, 2013
Last verified: December 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This study will look at Drug-Drug Interactions Between AT2220 (duvoglustat hydrochloride) and alglucosidase alfa (ERT) in Patients with Pompe Disease.
|Pompe Disease
|Drug: duvoglustat hydrochloride
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|An Open-Label, Multi-Center, Study to Investigate Drug-Drug Interactions Between AT2220 (Duvoglustat Hydrochloride) and Alglucosidase Alfa in Patients With Pompe Disease
Resource links provided by NLM:
Genetics Home Reference related topics: Pompe disease glycogen storage disease type IX
MedlinePlus related topics: Drug ReactionsU.S. FDA Resources
Further study details as provided by Amicus Therapeutics:
Primary Outcome Measures:
- Safety [ Time Frame: 3 months ]adverse events (AE) (including infusion reactions), clinical laboratory tests (hematology, urinalysis, serum chemistry including creatine kinase, LDH, alkaline phosphatase, ALT and AST), urine glucose tetrasaccharides (Hex4), 12-lead ECGs, physical examinations, vital signs, and muscle strength tests
- Pharmacokinetics [ Time Frame: 1 month ]Plasma GAA Cmax and AUC for enzyme activity after an alglucosidase alfa infusion alone and after pre-administration of single ascending doses of AT2220; total protein concentration will also be evaluated for each infusion
Secondary Outcome Measures:
- GAA activity in muscle [ Time Frame: Day 3 or Day 7 ]GAA levels in skeletal muscle at Day 3 or Day 7 after a single intravenous administration of alglucosidase alfa alone and in combination with single ascending oral doses of AT2220 by measuring GAA enzyme activity and protein levels
- AT2220 concentration in muscle [ Time Frame: Day 3 or Day 7 ]The concentration of AT2220 in skeletal muscle tissue homogenate on Day 3 or Day 7 after pre-administration of single ascending oral doses of AT2220 in Period 2.
|Study Start Date:
|October 2011
|Study Completion Date:
|January 2013
|Primary Completion Date:
|December 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Cohort 1
Drug: duvoglustat hydrochloride
Single oral dose
Other Name: AT2220
|Experimental: Cohort 2
Drug: duvoglustat hydrochloride
Single oral dose
Other Name: AT2220
|Experimental: Cohort 3
Drug: duvoglustat hydrochloride
Single oral dose
Other Name: AT2220
|Experimental: Cohort 4
Drug: duvoglustat hydrochloride
Single oral dose
Other Name: AT2220
Detailed Description:
This will be a multi-center, international, open-label, two-period, fixed-sequence crossover study to evaluate the safety and pharmacokinetic effect of single ascending doses of AT2220 on GAA administered 1 hour before initiation of a single alglucosidase alfa infusion. During Period 1 subjects will receive a single intravenous infusion of alglucosidase alfa. During Period 2, each subject will receive one single oral dose of AT2220 one hour prior to initiation of a single alglucosidase alfa infusion.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female, diagnosed with Pompe disease and between 18 and 65 years of age, inclusive
- Subject has been on a stable regimen and dose of alglucosidase alfa or at least 3 month before screening (stable regimen defined as currently receiving alglucosidase alfa every 2 weeks and stable dose defined as not varying by more than ± 10%)
- Subject has an estimated creatinine clearance ≥ 50 mL/min at Screening; eGFR to be estimated using the 4-parameter MDRD equation:
eGFR (mL/min/1.73 m2) = 175 x (Scr)-1.154 x (Age)-0.203 x (0.742 if female) x (1.212 if African-American)
- Male and female subjects of childbearing potential agree to use medically accepted methods of contraception during the study and for 30 days after study completion
- Subject is willing and able to provide written informed consent and is able to comply with all study procedures
Exclusion Criteria:
- Subject has had a documented transient ischemic attack, ischemic stroke, unstable angina or myocardial infarction within the 3 months before Screening
- Subject has clinically significant unstable cardiac disease (e.g., cardiac disease requiring active management, such as symptomatic arrhythmia, unstable angina or NYHA class III or IV congestive heart failure)
- Subject requiring mechanical ventilation or is confined to a wheelchair
- Subject has a history of allergy or sensitivity to study drug (including excipients) or other iminosugars (e.g., miglustat, miglitol)
- Subject is pregnant or breastfeeding
- Subject tests positive for hepatitis B surface antigen or hepatitis C antibody
- Subject has received any investigational/experimental drug or device within 30 days of Screening
- Subject has any intercurrent illness or condition that may preclude the subject from fulfilling the protocol requirements or suggests to the investigator that the potential subject may have an unacceptable risk by participating in this study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01380743
Please refer to this study by its ClinicalTrials.gov identifier: NCT01380743
|United States, Arizona
|Phoenix Neurological Associates, Ltd
|Phoenix, Arizona, United States, 85018
|Neuromuscular Research Center
|Scottsdale, Arizona, United States, 85258
|United States, California
|University of California Irvine - Neuromuscular Program
|Orange, California, United States, 92868
|United States, Florida
|University of Florida, Department of Pediatrics, Powell Gene Therapy Center
|Gainsville, Florida, United States, 32610
|United States, Georgia
|Emory University
|Decatur, Georgia, United States, 30033
|United States, Kansas
|University of Kansas Medical Center
|Kansas City, Kansas, United States, 66160
|United States, Montana
|Great Falls Clinic
|Great Falls, Montana, United States, 59405
|United States, North Carolina
|Duke University Medical Center
|Durham, North Carolina, United States, 27710
|United States, Ohio
|Cincinnati Children's Hospital Medical Center - Dept of Human Genetics
|Cincinnati, Ohio, United States, 45299
|United States, Oregon
|Oregon Health & Science University
|Portland, Oregon, United States, 97239
|United States, Virginia
|LSD Research and Treatment Center, CFCT
|Springfield, Virginia, United States, 22152
|Canada, Ontario
|McMaster University Medical Center
|Hamilton, Ontario, Canada, L8N 3Z5
|Hospital la Salpetriere Institut de Myologie
|Paris, France, 75013
|United Kingdom
|National Hospital for Neurology and Neurosurgery
|London, Queen Square, United Kingdom, WC1N 3BG
|Salford Royal NHS Trust Hope Hospital
|Salford, United Kingdom, M68 HD
Sponsors and Collaborators
Amicus Therapeutics
|Study Director:
|Medical Monitor
|Study Sponsor
More Information
Keywords provided by Amicus Therapeutics:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on June 23, 2017
|Responsible Party:
|Amicus Therapeutics
|ClinicalTrials.gov Identifier:
|NCT01380743 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 23, 2011
|Last Updated:
|December 5, 2013
Keywords provided by Amicus Therapeutics:
Pompe disease
Additional relevant MeSH terms:
Glycogen Storage Disease Type II
Lysosomal Storage Diseases, Nervous System
Brain Diseases, Metabolic, Inborn
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Glycogen Storage Disease
Carbohydrate Metabolism, Inborn Errors
Lysosomal Storage Diseases
Metabolic Diseases
ClinicalTrials.gov processed this record on June 23, 2017


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I recently read a piece by Penelope Trunk on CNN.com about why she thinks law school is a waste of time. In a nutshell: lawyers are really salespeople;
you're going to end up working at a big firm even if you don't plan to; going to law school is a cop out instead
of facing the real world; having a J.D. isn't useful; and you shouldn't think you're different than others.
Since I'm not an attorney, I can't really comment on the truth to her statements, but you can. What do you think about the column? Do you agree or is she just trying to stir the pot?


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EIA: little change in 2013 U.S. coal production
Source: U.S. Energy Information Administration, Short-Term Energy Outlook
EIA's Short-Term Energy Outlook projects total U.S. coal production in 2013 to be close to its 2012 level in the November 2012 Short-Term Energy Outlook as coal stockpile drawdowns and lower exports offset a projected increase in domestic coal consumption.
The November 2012 Short-Term Energy Outlook forecasts a 7% decline in coal production in 2012 from 2011 as domestic consumption, primarily in the electric power sector, falls. Coal production for the first three quarters (January-September) of 2012 was 46 million short tons (MMst) below the same period in 2011. Appalachian and Western region coal production are expected to both decline by 8% in 2012, but the production decline in the Interior should be lower, at 3%, because of strong demand for Illinois Basin coal. However, Western region coal output is expected to reverse course in 2013 and grow 5% to 571 MMst, while Appalachian and Interior region coal production are expected to fall for a second straight year.
*Disclaimer: The information in the Market Commentaries was obtained from sources believed to be reliable, but we do not guarantee its accuracy. Neither the information nor any opinion expressed therein constitutes a solicitation of the purchase or sale of any futures or options contracts.
Copyright CME Group All rights reserved.


text:
A land bank is a public authority or nonprofit created to efficiently acquire, hold, manage and develop foreclosed property, as well as other vacant and abandoned properties.
Land banks have clear streamlined procedures to clear title, transfer properties to responsible owners, and acquire tax delinquent properties without risking their sale to speculators.
Land banks are a best practice that more than 75 governments have adopted, including Cleveland, Louisville, Atlanta, and Genesee County, MI.
As of 2010, the estimated number of physically, economically, or for other reasons, distressed parcels in Pittsburgh was approximately 35,000 - constituting 5,603 acres or 18.7% of the land area of the City.
In 2011, it was estimated that the cost to manage, to baseline standards, all of the blighted land in the City of Pittsburgh would be $20,457,155 or $1,265 per parcel per year. This is what would be the direct cost to the City to simply maintain the problem.
While the City has taken advantage of state-given tax foreclosure powers and, to a very small extent, shepherded some of its land from blight to vibrancy over the last 15 years, the spread of these blighted conditions outpaces our ability or capacity to control or reclaim it.
At the current rate the City recycles tax-delinquent land, it would take 60 years to clear the existing backlog.
The Pittsburgh Land Bank bill provides the legal framework for the creation of a separate entity from the City that would be responsible for recycling and re-purposing tax delinquent properties.
The Land Bank will acquire, through various means, tax delinquent parcels throughout the City, and make the acquisition of these properties easier.
This proposed legislation will transform Pittsburgh's current land recycling system from a fragmented and disjointed process into a single entity, enabling residents and community groups to effectively transform vacant and abandoned properties in their neighborhoods.
The Pittsburgh Land Bank will level the playing field in community development throughout our City, allowing all community groups to have a hands-on role in revitalizing their neighborhoods - not just those with full-time staff capacity.
1/14/14 - Pittsburgh City Paper: Gross introduces land bank legislation


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|"Shapira, Yoav" <Yoav.Shap...@mpi.com>
|RE: Tomcat 4.06 Adjust Memory Requirements
|Fri, 25 Apr 2003 17:11:10 GMT
Howdy, Where did you search that you could find information on this topic? Every archive has dozens of messages like this. Add the -XmxNm to your JAVA_OPTS argument in $CATALINA_HOME/bin/catalina.sh. N is the max heap in megabytes. You can look on the java.sun.com site (search for "VM Options") for more JVM and memory tuning options. You can search this list for other ways of setting these options, e.g. the windows registry for tomcat as a service on windows. Yoav Shapira Millennium ChemInformatics >-----Original Message----- >From: Scott Purcell [mailto:email@example.com] >Sent: Friday, April 25, 2003 1:08 PM >To: email@example.com >Subject: Tomcat 4.06 Adjust Memory Requirements > >Hello, > >I am running a pair of Win2000 boxes here with Tomcat 4.06 on them. Tomcat >is throwing up customers do large (200+ MB) multipart uploads. I have >tried to limit the size of the uploads, but it doesn't happen until the >file is at Tomcat, so I cannot catch it there. So I am going to reinstall >our dev box early next week and could use some advice on adjusting the >amount of memory I can give to the servlet engine. I would like to set some >ceiling that would minimimize the out of memory error that occurs when >large uploads occur. > >I have searched for information on this, but I do not see much out there >that is in-line to what I need to do. Also I want to be able to run this as >a service. > >Does anyone have any info, sites to check out, etc. where I can accomplish >this mission.? > >Thanks >Scott > >--------------------------------------------------------------------- >To unsubscribe, e-mail: email@example.com >For additional commands, e-mail: email@example.com This e-mail, including any attachments, is a confidential business communication, and may contain information that is confidential, proprietary and/or privileged. This e-mail is intended only for the individual(s) to whom it is addressed, and may not be saved, copied, printed, disclosed or used by anyone else. If you are not the(an) intended recipient, please immediately delete this e-mail from your computer system and notify the sender. Thank you. --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
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Assisted Conceptions (and all the bits in-between) Volume 11(1001 Posts)
I really hope I haven't missed someone else starting this!
Great will do prambo :-)
I'm also going to have a consultation with city fertilty te Gennet now I have time and also because I have access to my consultant there already so at least I can seek advice through both clinics :-)
prambo Just realised I haven't thought about the scans etc after conceiving though IVF abroad. If I had success with reprogenosis what happens about the early monitoring? Do you have to find a private clinic back in the uk who will undertake your scans? If so will uk IVF clinics take you back on to monitor this?
Lucky, good question. I have had six scans so far on the NHS. This is because I contacted my old consultant who prescribed Clomid to me late last year and performed my lap & dye this year and told him I was pregnant. I begged him to prescribe the £450 worth of drugs I needed post-BFP and he agreed! He also scans me now whenever I need reassurance. I'm incredibly fortunate because my IVF at RG was nowt to do with him and he effectively signed me off after my lap in February.
I would absolutely contact your network of health professionals here if you get your BFP abroad. You've paid a lot of money for their services so far and with the right begging angle I believe we can get pretty much what we want as women
Haha been there prambo my trust will not provide any drugs before 12 weeks and I just know they won't offer me any scans. At least I could def. not rely on either happening. So looks like I would need to check a private UK clinic would be prepared to take me back on. I guess this is another up side of Gennet having city fertilty linked to them in London. Guess I just need to check that any of my three uk clinics I've used would be happy to take on the after care. :-)
Any further in your decision-making, Lucky? How are you feeling? Not too stressed, I hope.
Hi prambo had a really detailed email back from dr Martin at RP actually suggesting we could still use my eggs as my levels in April were good and if they were the same again, which he suspects they will be there shouldn't be a reason not to use them! BUT we are still going to go ahead down the double donor route! As we'd still be taking such a leap of faith and can't keep facing yet more heart ache! Still feels a big decision but ndodnt believe the decision will get any easier until we take it!
Waves to all :-)
Blimey, Lucky! What an offer to use your own eggs. I think you're absolutely right not to gamble in this way though and to stick to your donor plan.
Hello Ladies
Sorry for the interruptions.
Lucky - how are you? I read your DD plan. Im also planning the same route. Today is my last day in Athens. i came here a few days ago for a hysteroscopy arranged by Serum clinic. I wanted this procedure done before i went ahead with the FET (in uk). Good job i did - the surgeons removed scar tissues in cervix, uterus and made an implantation cut to help with implantation.
Also - before I flew I made contact with an ivf coordinator British nurse Ruth directly through "email@example.com". she works for a clinic called Iakentro. i read up alot about this clinic. It does everything. Has high success rates for FET. i contacted her directly via email initially and then telephone. She asked for my photo and DH. I gave mine as i told her i probably be doing DD alone as DH is undecisive (she made me feel at ease and all of my Q & A were answered including costs for DD). DD is very costly in UK. The photo is to find donors that matches my looks etc. we met up in Marousi Athens is where the iakentro clinic is (the athen branch). She coordinates everything from beginning to finish. Pls note Ruth does the organisation stuff only if you contacted her directly. If you go through the clinic then the staff does it (not sure about language barrier issues). With Ruth i can communicate freely and she is fast with her responses. Her fee is inclusive in the package. You dont pay any extra for her services. As for cost- it wont break my bank. "ociwoman" on the ivf.ca fotum travelling abroad ivf thread posted a thorough breakdown of the cost of ivf for Iakentro clinic. Very helpful for me as im conscious of costs. pls feel free to ask me anything.
I hope this is helpful.
Take care now.
Oops. I dont know how i managed to pist the same message twice. Sorry ladies
Just wanted to say hi....no real progress her at the moment. Popped my first provera today. Not really sure why I need a bleed before going on the pill but who am I to argue?!
Hiya, Vall. I am very excited to read about your current plans and upcoming cycle - would you please keep us updated each step of the way so we can cheer you on? I often think of you and the horridness is all in the past, I am sure
How are you, Lucky?
Thanks lovely! Happy to share every dildocam, little prick and trouser dropping moment. May even update on the IVF
Where are you now, I think you were 2 weeks further on from me so I am guessing 16 weeks??
Hi all
miu thanks for sharing this info. So sorry to hear you may have to take the double donor route alone. That can't be easy to have in the back of your mind whilst FETing. Thinking of you and sending you plenty of positive vibes.
val good luck huni - boy do you deserve success and some trouble free days.
AFM - enjoying abit of IVF down time. So important to have some care free time again with my hubby. Start some counseling today (inline) with a counsellor that comes highly recommended for donor counselling.
Not putting any pressure on ourselves about next steps. We are lined up for our mock DD round in Czech Reprogensis next month and so we cycle November. However still light consider using my eggs. We shall see how this next month or so goes and if a decision comes to light - we will go with it!
How's everyone else getting on?
Please may I join you? I am a 39 year old TTC #2 for over 12 months now. I've been diagnosed with secondary infertility and it seems that my only solution is to have IVF……... And sadly time is not on my side as I'll be 40 in November. Unfortunately my DH & I have cannot afford to have IVF right now (we are not entitled to IVF on the NHS). We've calculated that we may be able to save for one cycle of IVF by the time I'm almost 42
So it was with great interest when I read further up the thread of the possibility of having IVF abroad. I know one of the ladies here has done it and she is now pregnant – Congratulations Prambo. How would I go on about finding out the best clinics, prices etc? Would it involve one long trip for the initial consultation and treatment or several trips abroad? Will it really work out cheaper than having it in the UK? I've been told that one cycle for IVF for me will cost between £5-7K.
So please please if you can help me with the above I will be very grateful. Looking forward to getting to know you all x
Vall, I'm 17 wks now! Flippin' amazing. It's a miracle, for sure I am very interested in any trouser-dropping shenanigans - IVF-related or not..
Lucky, yes, yes to down-time with hubby. I'm also excited for your plans - however they pan out.
London, you're very welcome here but I beseech you not to panic. You may feel that time has almost run out but it hasn't. I started TTC when I was 40 and got pregnant immediately. I lost the baby (11 wk scan showed only sac and placenta), had the operation to remove the remnants and never got pregnant again. We borrowed £5k from my dad and in Hune this year flew to Reprogenesis in the Czech Republic for IVF using donor eggs. It worked first time and here I am..17 wks pregnant. Donor egg IVF in the UK can cost between £7-9k and the donor can be traced. Where we went the donor remains anonymous.
You really have to decide whether you want to risk such an amount of money using your own eggs. We had that one sum of money from my dad and there was no more if this didn't work. Ergo we were not prepared to gamble on my own eggs. There is a 62% chance of success for over-40s using donor eggs at Reprogenesis. Using my own eggs in the UK gave us a 11% chance of success. It was a no-brainer for us. I turned 42 last month and this is my first baby.
If you wish to have more details of donor egg IVF at Reprogenesis then please PM me. You will also find a fantastic forum for women currently cycling at ReproG on this Fertility Friends website
Also, you can join these lovely ladies who are all TTC over 40. They are all getting pregnant at 40, 43 & 45 after having been told they were unlikely to conceive. Do join them for support. Good luck, and DON'T PANIC!
*Not Hune..June!
Prambo that's a really lovely post. Just the kind of thing that kept me going during my donor ivf cycles.
Welcome London - I'm in my 40s and have a LO care of donor egg ivf. It really is possible.
Lucky best of luck to you hon. You too dearcVallina.
Waves to anyone Ive missed.
Sending a tonne of positive vibes to each and every one of you. May you soon all know the sleepless nights, huge nappies, cuddles and smiles that I have with DD who is 12 weeks tomorrow.
Please don't stop believing
Pocket! 12 wks today! What a joy and a blessing. Erm...exactly how big are these bleddy nappies??
Don't Stop Believing: IVF can and does work!
Prambo, it's not the size really (although some are big) more the frequency! Apparently they get worse when you wean onto solids. But it's all in a days work
Pocket, I knew what you meant Have you got a little girl who sleeps well? (Are we allowed to talk about babies on here or is it inappropriate, do you think?)
Hi all
Gosh no - not inappropriate in my view, we've all been here through Lucky's journey and for me personally it does give me hope that this can happen!!
London welcome - I've been considering Reprogenisis who Prambo has had success with. We are looking at a double donor round after 5 failed ICSI rounds here in the Uk. For us its the fact that they are guaranteed to achieve two grade A embryos to put back and at least 2 to freeze. In 5 cycles we have never achieved embryos to freeze! So it is truly tempting. If you are not using your own eggs, you can go out and back in the same day I understand. If you DH is providing Sperm he needs to be there at egg collection time too. Flights to Brno seem to cost less than me getting train to London! But still I completely understand what a big decision it is for you both. All these lovely ladies here will offer you great support.
Val Mui any news?
Sunny if you are reading this at all - we would love to know that you are doing ok sweetie.
Hugs to all xx
Hi all,
Thanks for the welcome ladies, much appreciated.
Prambo, thanks but I slowly panicking away! My situation is exacerbated by our lack of funds. My lovely parents offered me the money to pay for one IVF cycle. My worry is is that £7k is a heck a lot of money and I'm not fancying my chances with only a 13% success rate! Hence I am willing to consider donor eggs but my DH is ot comfortable with the idea. Plus, I will only consider the donor egg route once all other avenues have been exhausted…. And I do noy feel that I at that stage just yet. Ask me again in 6 months and I'm sure that it wilol be a completely different story!
Just out of interest what is your history, why did you go down the door egg route? Thanks for the offer of a PM regarding your clinic, I will take you up on that! I will send you a PM at lunchtime.
Pocket congratulations on your LO. Where did you have your IVF? And what about your donor egg? This is probably a stupid question, but how do you choose a donor?
Lucky I am interested in the double donor route too. Does this mean they you will have two embryos put back in? Or are you putting in one and freezing the other? I really need to look in to this further just in case things do not pan out with my knackered eggs!
Prambo I think it's ok to talk about babies a bit - I always loved hearing about the success of others using AC.
Lucky, hello to you my lovely. Sending you a hug x
London, I had my treatment with the lovely Dr Venkat at http://hsfc.org.uk/fertility/?gclid=CIDzvqvq6bkCFeSWtAodHGsApg
I had two rounds with donor found by clinic. And was matched by physical characteristics. Got bfp but mc for round one. And bfn round two.
We then had a third round, still with Dr Venkat, but I found my own donor through a post on fertility friends. Again matched by physical characteristics.
It's also key to ensure donor has proven fertility, ie has had her own kids, so that you know things work.
Best of luck to you whatever you decide.
Don't stop believing
two rounds with first donor who
Ignore the bit at the bottom if that post. On mobile so a bit clumsy!
Hi ladies
Pocket - How are you and How is motherhood ?
Lucky: I'm going to have my DR injection on 4th Oct. Once my period comes I'll start lining prep for FET.
London - Welcome. You are not alone. I'm in my mid 40s and still try for my first baby. I had one failed Donor Egg IVF in the UK. I got 2 frozen embryos left which I will use before going abroad. If you go to the website fertilityfriendsforum you will get lots of information about donor eggs etc. Ging down the donor route abroad is definately cheaper than UK. The price you paid for in the UK does not include other charges like medications freezing of left over embryos etc. Youu can have consultation on the phone or skype the clinic abroad before you decide to check the clinic out. Itmight safe you some money if you get the baseline bloods done at your GP. Like Lucky said - the traceability of the donor is not available if you go abroad. In the UK the donor child can trace its biological parent once it reaches its 18th birthday. I don't mind either way - I'm more concerned about cost, waiting list and and not too much about filling out forms etc (red tape) I found a clinic in Greece called Iakentro (in Marousi area) does provide proven donor eggs or double donor for couples and single women. It's cost is reasonable. I just came back from Greece after a hysteroscopy. While I was there I visited this clinic and spoke to the IVF nurse coordinator Ruth ( a British nurse)- i will definately go there for future IVF. I going for my FET in the UK (hoping it will work). If it doesn't i will go down the DD route alone as DH is undecisive about using donor sperm. Please feel free to ask anything. I find these ladies here are very supportive.
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Doody Townley
Doody Townley (born 1925) was a driver of standardbred racehorses in New Zealand. He was associated with many champions and was a leading driver of harness horses in New Zealand.
He is notable for winning four Inter Dominion Championships, the premier trotting series of races between Australia and New Zealand. [1] Not surprisingly, he is also an inductee in the Inter Dominion Hall of Fame. Doody also won two Auckland Trotting Cups and the New Zealand Trotting Cup. These are the two top races in New Zealand.
Big race wins
- 1980 Inter Dominion Trotting Championship Hano Direct
- 1971 Inter Dominion Pacing Championship Stella Frost
- 1971 New Zealand Trotting Cup True Averil
- 1970 Auckland Trotting Cup Stella Frost
- 1968 Inter Dominion Trotting Championship Stylish Major
- 1966 Auckland Trotting Cup Waitaki Hanover
- 1965 Inter Dominion Pacing Championship Robin Dundee
- 1962 Great Northern Derby Tactile
- 1959 Great Northern Derby Sun Chief
Reference list
|The above article was imported from Wikipedia.org on 08/24/2010 and may be a modified version of the Original Wikipedia article. See this article's history page for a list of revisions which may have occurred after import. This article is displayed here courtesy of the Wikimedia Foundation, Wikipedia, and its authors/contributors in compliance with the Wikimedia Terms of Use Agreement. This article was imported and is licensed under the terms of the Creative Commons Attribution/Share-Alike License 3.0 (CC-BY-SA). Clicking on photos, videos, or drawings in this article will display copyright and license information for that non-text media where available.


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The Iconic Commemorative Picture From the 2012 Olympics
August 12, 2012 at 4:21 PM 1 comment
This picture should be on the front page of every newspaper in the country tomorrow. After all, this is what the Olympics are all about:
Entry filed under: Musings.
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Good photo. Thanks.
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Simonton Dealers Say Window Tax Credits Working
According to several Simonton Windows dealers, the tax credit homeowners receive when purchasing qualifying energy-efficient windows has indeed helped improve their business during the first half of 2009, the vinyl window maker reports.
"Right now we believe about 10 jobs a month are being sold to homeowners specifically because of the tax credit offering, and we expect that number to increase during the second half of the year," says Audie Stein, branch manager at Norandex in Billings, Mont. "Our contractor customers are doing a good job of educating homeowners on the potential for savings when upgrading to replacement window packages that meet the government's specifications.
"Consumers are doing the math. The tax credit is moving those people who had contemplated replacement window projects to actually make the commitment. Once they understand that the (Simonton) ETC glass package helps them earn the tax credit and see savings on their energy bills from the day the windows are installed, they're hooked."
Stein reports that his Norandex branch is selling an average of 45 residential window jobs a month. "Our overall numbers are running fairly close to 2008 sales," says Stein. "In today's economy, I'm certain those numbers would be far lower if the tax credit was not available."
Across the country in Pittsburgh, Pa., Jim O'Bryon, window department manager for McClure Johnston, credits Simonton's quick response to the government's tax credit launch with helping build his sales. "Simonton immediately created marketing materials and packaged their qualifying products under the ETC glass line, making it easy for us to sell the windows to our contractor and lumberyard customers," he says.
"We got out in front of this opportunity quickly. In many cases our contractor customers were the only ones in our market who truly knew and understood the tax credit issue. That's helped them take full advantage of a unique selling opportunity and gain extremely high close rates."
According to O'Bryon, the tax credit incentive has allowed his company to grow during a difficult economic time. "The bottom line is that we've picked up new market shares and our sales are up," he reports. "Working together with a good partner like Simonton on this issue has helped us transition the majority of our orders to ETC glass packages this year. That means solid sales for us and strong benefits for homeowners."
The tax incentives are also having an impact in the coastal market, according to the Parkersburg, W.Va.-based manufacturer. Down in Florida, where Clear Choice Windows and More Inc. focuses on selling impact-resistant windows to combat potential severe weather, Paul Hardy has also seen the benefits of the tax credit incentives.
"We began immediately in February to aggressively pitch the tax credit offering to homeowners and we're seeing positive results," says Hardy, vice president of the Tampa-based company. "We've seen a slight increase in our business in 2009 despite the bad economy.
"In my mind, the ETC glass packages available in the (Simonton) StormBreaker Plus product line account for the continued strength of our sales. These windows traditionally have the Solar-E glass package. The ETC Super Solar SBP glass packages match this perfectly and offer our customers the opportunity to apply for the tax credit. When you're making the major investment of replacing windows in your home with impact-resistant windows, you appreciate any savings you can find."
Simonton itself reported it started to bring back laid off production workers back in March. It attributed that in part to the increased sales coming from stimulus package tax credits for energy efficient windows and doors, as well as a normal seasonal upturn. The manufacturer has also branded a whole line of ETC glass packages for its windows and doors that meet the federal tax credit requirements.


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