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Computer Science Courses
Great Ideas in Computer Science
An introduction to the most important discoveries and intellectual paradigms in computer science, designed for students with little or no previous background. Explores problem-solving using high and low-level programming languages; presents an integrated view of computer systems, from switching circuits up through compilers and GUI design. Examines theoretical and practical limitations related to unsolvable and intractable computational problems, and the social and ethical dilemmas presented by such issues as software unreliability and invasions of privacy.
Discrete Mathematics for Computer Science
Widely applicable mathematical tools for computer science, including topics from logic, set theory, combinatorics, number theory, probability theory, and graph theory. Practice in reasoning formally and proving theorems.
Introduction to Computer Science I
Introduction to the intellectual enterprises of computer science and the art of programming. This course teaches students how to think algorithmically and solve problems efficiently. Topics include abstraction, algorithms, data structures, encapsulation, resource management, security, software engineering, and web development. Languages include C, Python, SQL, and JavaScript plus CSS and HTML. Problem sets inspired by real-world domains of biology, cryptography, finance, forensics, and gaming. Designed for concentrators and non-concentrators alike, with or without prior programming experience. 73% of CS50 students have never taken CS before.
Introduction to Computer Science II
Abstraction and design in computation. Topics include functional and object-oriented styles of programming, software engineering in the small, and models of computation. Our main goal is to understand how to design large programs to make them readable, maintainable, elegant, and efficient.
Systems Programming and Machine Organization
Eddie Kohler
Fundamentals of computer systems programming, machine organization, and performance tuning. This course provides a solid background in systems programming and a deep understanding of low-level machine organization and design. Topics include C and assembly language programming, program optimization, memory hierarchy and caching, virtual memory and dynamic memory management, concurrency, threads, and synchronization.
The Internet: Governance and Power
In this course, we study cyberspace governance. Cyberspace is a unique combination of physical and virtual properties. In this course, we view cyberspace as a structure consisting of three layers: the physical layer represented by the global communication infrastructure and two virtual layers, composed by the Internet layer and the social and economic layer. Our focus concentrates on the top two layers. The principles, norms, rules, and procedures that shape the cyberspace are studied in this course through quantitative analysis of data collected from different sources in the digital world. Data-oriented analysis of problems and policies in cyberspace will be illustrated by examining several case studies in the major internet platforms. The case studies will help students to understand the role of social algorithms, programs that rank and classify people and information and services that provide customized experiences. Ultimately, students learn how to use quantitative methods to understand different issues related to digital governance.
Contemporary Issues in Intelligence Gathering
The digital environment offers greatly expanded opportunities for intelligence gathering. This seminar will explore some of the most difficult problems arising in managing the collection and use of intelligence for national security, including compliance with the law; avoidance of, and remedies for, over collection; and protection of privacy and other fundamental values.
We will discuss how an intelligence community's activities can be meaningfully communicated to the public while respecting its sources and methods; how agencies might internally reconcile their various missions to protect the public and protect public values; and what a set of authorities and limitations for intelligence collection might look like if a clean slate were available on which to develop them. Please visit http://brk.mn/CIIG17 to access the application and read more about the course.
Supervised Reading and Research
Supervised individual study of advanced topics in computer science. A student wishing to enroll in Computer Science 91r must be accepted by a faculty member who will supervise the course work. A form available from the Student Affairs Office, Pierce Hall 110, must be filled out and signed by the student and faculty supervisor. Students writing theses may enroll in this course while conducting thesis research and writing.
Supervised Reading and Research
Supervised individual study of advanced topics in computer science. A student wishing to enroll in Computer Science 91r must be accepted by a faculty member who will supervise the course work. A form available from the Student Affairs Office, Pierce Hall 110, must be filled out and signed by the student and faculty supervisor. Students writing theses may enroll in this course while conducting thesis research and writing.
Privacy and Technology
What is privacy, and how is it affected by recent developments in technology? This course critically examines popular concepts of privacy and uses a rigorous analysis of technologies to understand the policy and ethical issues at play. Case studies: database anonymity, research ethics, wiretapping, surveillance, and others. Course relies on some technical material, but is open and accessible to all students, especially those with interest in economics, engineering, political science, computer science, sociology, biology, law, government, philosophy.
Intelligent Systems: Design and Ethical Challenges
For centuries, people have imagined smart machines in fictional stories. Computer systems now communicate in speech and text, learn, negotiate, and work in teams (with people and other systems). These intelligent-systems capabilities raise questions about the impact of such systems on people and societies. This course introduces the basic techniques of AI in the context of (science) fiction imaginings and ethical challenges. It examines the roles of design and of policy in reducing potential negative consequences. The course presumes a basic programming ability, but is accessible to concentrators in the humanities and social sciences as well as science and engineering.
Data Science 1: Introduction to Data Science
Kevin A. Rader
Data Science 1 is the first half of a one-year introduction to data science. The course will focus on the analysis of messy, real life data to perform predictions using statistical and machine learning methods. Material covered will integrate the five key facets of an investigation using data: (1) data collection - data wrangling, cleaning, and sampling to get a suitable data set; (2) data management - accessing data quickly and reliably; (3) exploratory data analysis – generating hypotheses and building intuition; (4) prediction or statistical learning; and (5) communication – summarizing results through visualization, stories, and interpretable summaries.
Data Science 2: Advanced Topics in Data Science
Mark Glickman,
Verena Kaynig-Fittkau
Data Science 2 is the second half of a one-year introduction to data science. Building upon the material in Data Science 1, the course introduces advanced methods for data wrangling, data visualization, and statistical modeling and prediction. Topics include big data and database management, interactive visualizations, nonlinear statistical models, and deep learning.
Introduction to the Theory of Computation
General introduction to the theory of computation, teaching how to reason precisely about computation and prove mathematical theorems about its capabilities and limitations. Finite automata, Turing machines, formal languages, computability, uncomputability, computational complexity, and the P vs. NP question.
Data Structures and Algorithms
Design and analysis of efficient algorithms and data structures. Algorithm design methods, graph algorithms, approximation algorithms, and randomized algorithms are covered.
Algorithms and Complexity
An accelerated introduction to theoretical computer science for students with strong mathematical preparation, to be taken in place of both Computer Science 121 and 124. Algorithm design methods, including graph algorithms, approximation algorithms, and randomized algorithms. Models of computation, computability theory, and computational complexity, including the P vs. NP question.
Networks—of social relationships, economic interdependencies, and digital interactions—are critical in shaping our lives. This course introduces models and algorithms that help us understand networks. Fundamental concepts from applied mathematics, microeconomics, and computer science will be presented through the lens of network science, in order to equip students to usefully analyze the "big data" generated by online networks. Applications discussed include the viral spread of ideas, maximizing influence, and the contagion of economic downturns. Concepts and tools covered include game theory, graph theory, data mining, and machine learning.
Computing Hardware
Introduction to the design, structure, and operation of digital computers; logic circuits and digital electronics; computer arithmetic; computer architecture; and machine language programming. Consideration of the design interactions between hardware and software systems.
Computer Networks
Networking has enabled the emergence of mobile and cloud computing, creating one of the most important technological paradigm shifts in computing of the past decade. The next major paradigm shift in computer networking will be the emergence of 5G wireless mobile networks, which will begin to replace the current 4G networks as early as 2019/2020. These further advancements in wireless networking are expected to transform the technological landscape over the next decade by enabling an endless possibility of new applications, including the Internet of Things and wireless virtual reality, through the emergence of wireless networks with gigabit speeds. In order to play a role in this era of new network-powered advancements, students must have a thorough understanding of emerging networking topics, especially in the wireless domain. Rather than teaching the basic networking protocols, which have become very mature and can be treated as a black box, in CS 143, we will teach the new issues and topics of interest, which will power important emerging applications. This focus on upcoming wireless advancements and mobile applications is the motivation for CS 143 this semester. The class will be organized into the following nine modules: A View of the Future: 5G—A World with Gigabit Wireless Networking; Basic Networking Concepts; Fundamental Radio Propagation Physics; Basic Wireless Networking Concepts: Wi-Fi, MAC protocols; New Fundamentals of Mobile Networking: 5G Millimeter Wave, Ultra Dense Networks (UDNs); Advanced Topics in 5G: Beam Forming, MIMO; 5G System Infrastructure: Network Function Virtualization and Software Defined Networking; 5G Applications: The Internet of Things and Massive Machine Type Communications; and Machine Learning Assisted Networking. Students in the course will read and discuss the latest wireless networking literature, gain hands-on experience through a programming assignment, and have the opportunity to present the concepts learned in the course through writing a final position paper on emerging wireless networking technologies.
Computer Architecture
Review of the fundamental structures in modern processor design. Topics include computer organization, memory system design, pipelining, and other techniques to exploit parallelism. Emphasis on a quantitative evaluation of design alternatives and an understanding of timing issues.
Programming Languages
Comprehensive introduction to the principal features and overall design of both traditional and modern programming languages, including syntax, formal semantics, abstraction mechanisms, modularity, type systems, naming, polymorphism, closures, continuations, and concurrency. Provides the intellectual tools needed to design, evaluate, choose, and use programming languages.
Operating Systems
This course focuses on the design and implementation of modern operating systems. The course discusses threads, processes, virtual memory, schedulers, and the other fundamental primitives that an OS uses to represent active computations. An exploration of the system call interface explains how applications interact with hardware and other programs which are concurrently executing. Case studies of popular file systems reveal how an OS makes IO efficient and robust in the midst of crashes and unexpected reboots. Students also learn how virtualization allows a physical machine to partition its resources across multiple virtual machines. Class topics are reinforced through a series of intensive programming assignments which use a real operating system.
Software Engineering
An introduction to principles of software engineering and best practices. Students work in teams on the design, implementation, and deployment of a term-long project that solves a problem on campus. Structured as supervised independent study with weekly milestones and weekly meetings for design discussions and code reviews with an advisor.
Data Systems
We are in the big data era and data systems sit in the critical path of everything we do. We are going through major transformations in businesses, sciences, as well as everyday life - collecting and analyzing data changes everything and data systems provide the means to store and analyze a massive amount of data. This course is a comprehensive introduction to modern data systems. The primary focus of the course is on the modern trends that are shaping the data management industry right now: column-store and hybrid systems, shared nothing architectures, cache conscious algorithms, hardware/software co-design, main-memory systems, adaptive indexing, stream processing, scientific data management, and key-value stores. We also study the history of data systems, traditional and seminal concepts and ideas such as the relational model, row-store database systems, optimization, indexing, concurrency control, recovery and SQL. In this way, we discuss both how and why data systems evolved over the years, as well as how these concepts apply today and how data systems might evolve in the future. We focus on understanding concepts and trends rather than specific techniques that will soon be outdated - as such the class relies largely on recent research material and on a semi-flipped class model with a lot of hands-on interaction in each class.
An introduction to key design principles and techniques for visualizing data. Covers design practices, data and image models, visual perception, interaction principles, visualization tools, and applications. Introduces programming of web-based interactive visualizations.
Computer Graphics
This course covers the fundamentals of 3D computer graphics using a modern shader-based version of OpenGL. Main topics include: geometric coordinate systems and transformations, keyframe animation and interpolation, camera simulation, triangle rasterization, material simulation, texture mapping, image sampling and color theory. The course also touches on ray tracing, geometric modeling and simulation-based animation.
Design of Useful and Usable Interactive Systems
The course covers skills and techniques necessary to design innovative interactive products that are useful, usable and that address important needs of people other than yourself. You will learn how to uncover needs that your customers cannot even articulate. You will also learn a range of design principles, effective creativity-related practices, and techniques for rapidly creating and evaluating product prototypes. You will also have several opportunities to formally communicate your design ideas to a variety of audiences. You will complete two large team-based design projects.
Machine Learning
David Parkes
Introduction to machine learning, providing a probabilistic view on artificial intelligence and reasoning under uncertainty. Topics include: supervised learning, ensemble methods and boosting, neural networks, support vector machines, kernel methods, clustering and unsupervised learning, maximum likelihood, graphical models, hidden Markov models, inference methods, and computational learning theory. Students should feel comfortable with multivariate calculus, linear algebra, probability theory, and complexity theory. Students will be required to produce non-trivial programs in Python.
Artificial Intelligence
Introduction to AI focused on problems in reasoning about action and rational decision making, covering search, knowledge representation and planning. Search: heuristics, informed search and optimization; constraint satisfaction; game playing. Knowledge representation: logics, efficient logical inference, reasoning about categories. Planning: action representations and planning algorithms, hierarchical task networks, sequential decision making. Applications to multi-agent systems, robotics and natural-language processing. Discussion of relevant work in philosophy, economics, and decision theory.
Computing Foundations for Computational Science
An applications course highlighting the use of computers in solving scientific problems. Students will be exposed to fundamental computer science concepts such as computer architectures, data structures, algorithms, and parallel computing. Fundamentals of scientific computing including abstract thinking, algorithmic development, and assessment of computational approaches. Students will learn to use open source tools and libraries and apply them to data analysis, modeling, and visualization of real scientific problems. Emphasizes parallel programming and "parallel thinking."
Systems Development for Computational Science
This is a project-based course emphasizing designing, building, testing, maintaining and modifying software for scientific computing. Students will work in groups on a number of projects, ranging from small data-transformation utilities to large-scale systems. Students will learn to use a variety of tools and languages, as well as various techniques for organizing teams. Most important, students will learn to fit tools and approaches to the problem being solved.
Algorithms at the Ends of the Wire
Covers topics related to algorithms for big data, especially related to networks. Themes include compression, cryptography, coding, and information retrieval related to the World Wide Web. Requires a major final project.
Advanced Algorithms
Advanced algorithm design, including but not limited to amortization, randomization, online algorithms, graph algorithms, approximation algorithms, linear programming, and data structures.
Efficiently generating objects that ``look random'' despite being constructed using little or no randomness. Connections and applications to computational complexity, cryptography, and combinatorics. Pseudorandom generators, randomness extractors, expander graphs, error-correcting codes, hash functions.
Topics in Cryptography and Privacy
Topics in cryptography and data privacy drawn from the theoretical computer science research literature. Focus for 2016-2017: Differential Privacy -- a mathematical framework for privacy-preserving analysis of datasets, which enables aggregate computations while preventing the leakage of individual-level information -- and statistical validity in adaptive (exploratory) data analysis.
Proofs, Beliefs and Algorithms through the lens of Sum of Squares
In this graduate seminar we will cover recent research on the use of mathematical programming for problems arising from optimization, machine learning, computational complexity and more, with a particular focus on the Parrilo-Lasserre "Sum of Squares" semidefinite programming hierarchy. We will discuss both lower and upper bounds, as well as how such mathematical programs give rise to a general theory of computational difficulty, computation vs. sample size tradeoffs, and computational analogs of Bayesian probabilities.
More concretely, we will touch some of the following topics:
* Upper and lower bounds for various average case problems, including random constraint satisfaction, planted clique, and problems arising from machine learning.
* Speeding up Sum of Squares algorithms.
* Relation to Khot's Unique Games Conjecture (UGC) and the SOS approach to refuting the UGC.
* Can SoS be optimal algorithm in some settings? What are the candidate algorithms who could do better? In what settings might *linear* programming already be optimal? What kind of implication could such optimality entail?
* Semidefinite extension complexity, relations to communication complexity.
* Relation to statistical physics, and algorithms such as belief propagation and survey propagation.
* Relation to quantum information theory, quantum entanglement, and the log rank conjecture.
* Reducing asymptotic SoS questions to finite size via symmetry and relation to Razborov's flag algebras and Turan problems.
However, this is a fast moving research area and our plans may change as new results, as well as new understandings of old results, come to light. The course will not require much mathematical background beyond so called "mathematical maturity". However, some familiarity with notions such as convexity, linear programming duality, separation oracles, eigenvalues/eigenvectors and positive semidefiniteness, could be helpful.
Topics in Theoretical Computer Science: Coding Theory
Introduces essential elements the theory of error-correcting codes. Focuses on the basic results in the area, taught from first principles. Special focus will be given on results of asymptotic or algorithmic significance. Principal topics include
- Construction and existence results for error-correcting codes;
- Limitations on the combinatorial performance of error-correcting codes;
- Decoding algorithms
- Applications to other areas of mathematics and computer science.
Lecture notes for this course from previous offerings give further details on the material covered. These may be found at http://people.csail.mit.edu/madhu/ST13/
Advanced Computer Architecture
The contents and course requirements are similar to those of Computer Science 146, with the exception that students enrolled in Computer Science 246 are expected to undertake a substantial course project.
Advanced Topics in Programming Languages
Seminar course exploring recent research in programming languages. Topics vary from year to year. Students read and present research papers, undertake a research project.
Projects and Close Readings in Software Systems
Modern software systems construction and analysis. Distributed systems; operating systems; networks; data centers; big data; emerging systems deployments. Close, careful reading of research papers and code, coupled with programming projects. Readability and programmability. Topic focus will change each offering. May be repeated for credit with instructor permission.
Research Topics in Operating Systems
An introduction to operating systems research. Paper-based seminar course that introduces students to the state of the art in systems research through historical and quantitative lenses. Students will read and discuss research papers and complete a final research project.
Systems Security
This course explores practical attacks on modern computer systems, explaining how those attacks can be mitigated using careful system design and the judicious application of cryptography. The course discusses topics like buffer overflows, web security, information flow control, and anonymous communication mechanisms such as Tor. The course includes several small projects which give students hands-on experience with various offensive and defensive techniques; the final, larger project is open-ended and driven by student interests.
Big Data Systems
Big data is everywhere. A fundamental goal across numerous modern businesses and sciences is to be able to exploit as many machines as possible, to consume as much information as possible and as fast as possible. The big challenge is "how to turn data into useful knowledge". This is far from a simple task and a moving target as both the underlying hardware and our ability to collect data evolve. In this class, we will discuss how to design data systems and algorithms that can "scale up" and "scale out". Scale up refers to the ability to use a single machine to all its potential, i.e., to exploit properly the memory hierarchy and the multiple CPU and GPU cores. Scale out refers to the ability to use more than 1 machines (typically 100s or 1000s) effectively. This is a research oriented class. Every week we will read two modern research papers; one from the scale up area and one from the scale out area. We will use examples from several areas, including relational systems and distributed databases, graph processing systems (i.e., for social networks), key value stores, noSQL and newSQL systems as well as mobile computing. Each student will work on a semester long data systems research project (in groups of 2-4 students) which can be in any of the above areas and will be based on an open research problem.
Advanced Topics in Artificial Intelligence
Seminar course exploring research directions in artificial intelligence (AI), typically combining two or more of such areas as multi-agent systems, natural-language processing, machine learning, reasoning under uncertainty, representation systems. Topic for Spring 2017: Multi-agent systems: collaboration, coordination and loosely-coupled teamwork.
Topics in Machine Learning
Pierre Jacob
The Ultimate Inference Bake-off... with Bayesian Nonparametrics!
This course is fundamentally about gaining a deep understanding of state-of-the-art inference techniques for probabilistic models, with the goal of also thinking of ways to address their shortcomings. Since probabilistic models are obviously a very large area, we'll focus on Bayesian Nonparametric models. After a brief overview of Bayesian Nonparametric models we'll begin our ultimate inference bake-off: starting with the tried-and-true techniques and going to the current state-of-the-art. Along the way, we'll learn what works when, and where the gaps are. Students will complete several programming assignments, lead discussion on papers, and complete a substantial final project.
Computer Science Research Seminar
This course introduces first year Computer Science PhD students to the CS colloquium series. Required for G1 PhDs in CS.
Computer Science Research Seminar
This course introduces first year Computer Science PhD students to the CS colloquium series. Required for G1 PhDs in CS.
Special Topics in Computer Science
Supervision of experimental or theoretical research on acceptable computer science problems and supervision of reading on topics not covered by regular courses of instruction.
Special Topics in Computer Science
Supervision of experimental or theoretical research on acceptable computer science problems and supervision of reading on topics not covered by regular courses of instruction.
SEAS Teaching Practicum
Gain effective skills for teaching applied sciences. Topics: presentation and communication, grading and giving feedback on assignments, cognition and learning, classroom practice and student interactions. Seminar style with an emphasis on observation, practice, feedback, discussion, and reflection.


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Build Those Muscles Today
There are a number of people who have become crazy about building their body in the last few months. While spending hours at the gym does not really give the results that you need there are people that eventually turn to steroids. While there are a number of Steroids that are available in the market the one steroid that you should trust is dbol. Dianabol is one of the best steroids that is available in the market.
This steroid has absolutely no side effects and it gives the desired result and also assists with muscle building in the body. When you start using Dianabol you need to ensure that you are working out at the same time. Without working out consuming Dianabol will have no effect on the body. Once you start working out regularly and consume Dianabol you will realize that you have more energy and a lot more stamina to continue exercising than you had before.
With Dianabol your level of energy and enthusiasm will increase continuously. This will help you work out for longer hours in the gym and you will get the desired body that you always craved for. Once you regularly start working out and you get your desired results you can even just continue using Dianabol. There are absolutely no side effects with this steroid and you can use it for as long as you want as long as you are working out at the same time. Once you start using this steroid you will realize the wonders that it does for your body. This is better than any other steroid or supplement that you use for your body. With other steroids there are side effects such as hair loss and other health problems. There is no such problem that you face with Dianabol.

subset: commoncrawl


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|Price incl. VAT
|£16.90 £15.90
|Price excl. VAT
Ionization skin massager Relax Beauty brings you the perfect skin care from the comfort of home. The technology of generating ions greatly improves the absorption of active substances of creams, serums and masks deeper into the skin. A nice extra vibration massage improves blood circulation and lymphatic system faces. The result is a healthy and radiant skin a youthful appearance.
The unit is very gentle on the skin and is suitable for all skin types. Power is using AAA batteries. Its use is very easy, safe and painless. Simply attach the applicator from stainless steel to skin and turn on the device. Ionization and vibrating massage starts automatically when the application head comes into contact with the skin. Circular motion is treated successively all parts of the face, it is ideal to perform massage 3x per week in the range from 5 to 10 minutes. The ergonomic design and compact size for easy handling and high comfort use.
ionization massage facial skin
1x AAA battery (not included)
<120 mA
Static current:
11 cm
50 g
Specifications can be changed without notice. Images are for illustrative purposes only. Retail Price (MSRP) means the manufacturer's/supplier's suggested retail price.
Link to Manufacturer's Website: Enter link to the external review


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4 Cell Original Battery for Dell Latitude E5400 E5500 Series (2400mAh)
Item No.: Dell - BL-5484-ORIGINAL
Ratings: (4 reviews).
Availability: In Stock
Ships from U.S Warehouse. Most customers receive within one week.
Price: $79.95 MSRP:$149.95 (Saved $70.00)
Free Ground Shipping to US only
Note: Order placed before 12:30PM Pacific Standard Time will normally be processed in the same day.
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- Genuine Original Dell Laptop Battery
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- Battery type: Li-ion
- Battery Voltage : 14.8V
- Capacity: 4 cells, 2400mAh, 37Wh
- Dell part numbers: 0X064D, KM760, KM769, 312-0762, KM760, KM769
Product Reviews
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Ripping Away
I didn't go back to Nick's straight after school. I went to a little field behind the school. I had made a little den when I was Jade. I crawled inside it, and lay back. Then, it happened. Pain surged through me, and I heard a tiny ripping sound. I gave a little cry, then was silent. The soul ad come out from the body. I grinned. I checked that I could get back in. I twitched my fingers, then left the body again. I flew out over the town, looking down. Something caught my attention. Ellie throwing herself onto Jerry.
I growled. I went down. Both had tears in thier eyes, and were both embracing. I gave another growl, to which Ellie looked up. She subsided it to the wind, and carried on holding him. I gave a 'hmmph', and left. I went back inside my body, and sat up. I got out from the den, and grabbed my bag. I grumbled to myself all te way back to Nick's house.
I saw him sat embraced with Jules, and I crept up the stairs without being noticed. I laid down, and buried my face into the white pillow, and began to cry. A few minutes later, a knock came at the door. I wiped the tears away. "Hello?" I choked out. Nick poked his head round the door, followed by Jules. They both came in.
"What's up?" said Nick. I shook my head. Jules seemed to feel sorry for me. She sat next to Nick. Fresh tears came to my eyes. "I-I-I'm sorry, it's just, A-Ally migt be alive i-if not for me-e-e-e, and I j-just saw Jerry-y-y-y-y-y. He was w-with that new girl E-Ellie. Hugging and c-crying. I just felt s-s-s-so sad, since Ally was torn away f-from Jerry, and now that girl c-comes, and he seems to have got over Ally, since Ellie l-l-looks and t-talks and l-laughs just like her. It's all-l-l-l my fault!!" I cried out, holding the pillow to my chest, and crying into my arm.
"How did you see them?" said Jules, moving closer to Nick. I explained how I had been ripped from the body. Nick looked so sad for me,as well as Jules. The irony of it. I get ripped away from my body, and Ally get ripped from hers and from Jerry. I'm thankful she's not here. She would be bound forever if she saw that. Then, I thought of Ethan. He had felt loss. So had I though. Jerry, Ethan and I had all had a love that had dies now.
Nick left the room, but Jules lingered She was looking at the charm bracelet. She fished something out if her pocket, and fumbled with the bracelet. She tied the tiny silver squiggle round my wrist with a piece of leather. She smiled, and left after that. I looked down at it, and smiled. I laid down, and left my body again. I found the lake in the park, and dove in. I went right to the bottom, and curled up there, thinking. Something caught my eye. Another spirit. nd something shining beside her. I swam (?) over, and picked up the silver thing. She looked up from her hands, and looked right into my eyes. She was beautiful. She put her face back into her hands. I picked up the shiney thing, not stopping to look at it. I flew back to Nick's house, dropped the silver thing on the floor, and returned to the body. I got up, and picked up the silver thing.
It was a little charm, fo a bag or phone maybe. It had and E and an L linked together.The E had an emerald on, and the L had a ruby. They were real too. They were pretty. I dried it by patting my jumper around it. I slipped it into my pocket, and frowned. That spirit...who had it been? I felt that she and the charm were related.....


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Spring Flowering Plants
For perennials, spring is the season of revival, rejuvenation and renewal when gardens sprout and quickly reach their peak beauty. Springtime marks the start of the annual growing and flowering cycle for most plants and this results in an eruption of color in the perennial landscape.Click here for the entire collection of Spring Flowering Plants.
Why Buy Perennials from Plant Delights Nursery?
- Guaranteed healthy, correctly labeled plants.
- All perennials personally-selected by Tony.
- Large, diverse selection of perennial plants online.
- All garden plants trialed in our test gardens.
- Rare, unusual, and North American native plants.
- Expert horticultural staff.
- Most plants propagated on-site, ensuring quality.
Tony's Favorites
Tony has seen a lot of perennials in his day. Here we share some of his absolute favorite perennial plants.Click here for the entire collection of Tony's Favorites.


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I don't know which should I get: a fat transfer, BBL or Brazilian butt revision. I'm looking for tremendously curvy body (Photo)
I'm looking for a tremendously curvy body with a tiny waist and heart shaped ass!!! It must look like my ass! And a well proportioned waist to hip ratio.
Doctor Answers 4
Lipo + BBL candidate, some advices:
Thanks for the question. In this regard, I recommend you waist and back Liposculpture, getting better curves especially in the waist, improving your body contour. Finally, I suggested take the fat we get and transfer to the buttocks and hips, to mold them and get better volume, contour and butt projection, is that we know as "Brazilian Butt Lift" (BBL).Kind regards
Brazilian Butt Lift/ Fat grafting/Liposuction/ High Definition Procedures/Butt Implants
Thank you for your question. From your photos, you appear to be an excellent candidate for Vaser Hi definition liposculpture with fat grafting to the buttocks. You should get a great result from liposculpture, giving you a more contoured and hourglass shape with better projection to your buttocks. I have done many body contouring procedures and specialize in Vaser Hi Definition liposculpture. Vaser Hi Definition body sculpting requires extensive specialized training. I am one of few surgeons in the United States that was personally trained by Dr. Alfredo Hoyos, the surgeon that developed this technique. Vaser Hi Definition liposuction uses the concepts of negative and positive spaces in relation to the underlying bony and muscle anatomy to define areas such as your six pack and create an athletic looking physique. The best way to assess and give true advice would be an in-person exam. Please see a board-certified plastic surgeon that specializes in aesthetic and restorative plastic surgery. Dr. Schwartz Board Certified Plastic Surgeon Director-Beverly Hills Breast and Body Institute #RealSelf100Surgeon #RealSelfCORESurgeon
Web reference: http://beverlyhillsbreastandbodyinstitute.com
I don't know which should I get: a fat transfer, BBL or Brazilian butt revision. I'm looking for tremendously curvy body (Photo)
Hi and thanks for your pictures. First, is a contraindication for any plastic surgery a patient with unrealistic expectations, meaning a wish to look exactly as other person's body, since body contour depends on many factors like genetics, hereditary conditions, body frame, age, skin texture, etc. So probably you will never be satisfied with any of your results. To get as nearest to the Body Contour you wish you will not only need Liposculpture and Fat Transfer to Buttocks ( Brazilian Butt Lift) but also a reduction of your waist by Abdominoplasty or Tummy Tuck, that will allow the thightening of your abdominal wall and the removal of excess skin in the area.
You might also like...
I don't know which should I get: a fat transfer, BBL or Brazilian butt revision. I'm looking for tremendously curvy body (Photo)
"Fat transfer"/"BBL" are the same meaning to which is called Brazilian Butt Lift. A "BBL" Brazilian butt lift harvest fat from areas ( Liposuction ) with the fat removed from the areas using your own fat it transfer to the buttocks and into the hips.The common donor sites for this procedure is your posterior waist/flanks, lateral thighs, back, waist, and anterior tummy. When you're looking for a cosmetic procedure you find a surgeon that has been certified by the American Board of Plastic Surgery. Choose a board certified plastic surgeon who is highly experience in Brazilian Butt Lifts. choose one wisely. Many surgeons, including myself, offer online virtual consultations where you send us your photos and we can estimate the cost. and free Face to face consultation. Thank you for your question .
Web reference: http://spectrum-aesthetics.com/brazilian-butt-lift/
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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It had been a particularly grueling day on the med/surg unit. Anne and I gazed at each other in weary frustration as we sat down to catch up on hours of documentation. The day had proved particularly distressing for Anne, who recently had lost a beloved family member to an acute myocardial infarction. Tears of frustration and helplessness pooled in her eyes as she began to verbalize just how tired she had grown of being perpetually busy and stressed while caring for patients.
When and why had the word busy grown so powerful that it had the ability to summarize and shape her day, Anne wondered.
Hours earlier, Anne barked at her husband over the phone when he called to inquire about her day. Im too busy to talk right now, she snapped, although she appeared more distressed than ever when she hung up. Later, she appeared equally distraught as a novice patient care technician asked for more personal protective equipment to stock an empty isolation room. Id be happy to get that for you, but Im too busy right now, she was overheard telling her peer. As a harried physician arrived to the floor, worried about time, chronically late to the office, Anne greeted him with additional words about the unit being extremely busy. The physician grew even more stressed, as if he alone assumed an additional burden for the units acuity.
As Anne and I sat down to chart, we began to wonder if this was the kind of attitude (or care) we wanted to be providing. Had kindness and empathy toward our patients (and loved ones) fallen by the wayside, victim to the ascendancy of busy? We worried about how/when/why we might have lost the essence of nursing, and how we could get it back.
We had little time to reflect or wonder, as several call lights began to flash in urgent synchrony. Anne hurried to the first one as I left in search of the next.
My patient had accessed her bell by mistake, and was heartily laughing at her misdemeanor. Annes patient, however, was distraught and restless. Newly diagnosed with brain metastases, and a potential infarct into the basal ganglia, the elderly man appeared saddened and puzzled to be alone in a strange room, with both hands secured by mittens, and no one he recognized to soothe the worry lines from his brow. I couldnt find my dog, he cried, growing more distressed by the minute. Everyone seems too busy to help me find my dog, he wept in a soft and helpless voice.
Anne immediately went into action, pulling a chair to the bedside as she soothed and quietly embraced the frantic patient. Im never too busy to help you find what you need, she assured the man, holding his mittened hands until he began to relax and breathe ever more slowly. As she spoke to the gentleman about his surroundings, and reassured him that we cared and would help keep him safe, I saw the beginnings of a smile twitch on his face. He didnt quite understand what was happening, but he recognized words of compassion, love and respect. Anne didnt see this man as another busy interruption to her day; she merely saw a frail man in distress, someone who needed a hand to hold and a kind voice to respond to his worries.
As Anne gently secured her patient in for the night, she served to remind me that nurses, although frustrated and distressed by endless demands on their time, also can be empowered by the challenges facing healthcare. If we refuse to fall prey to the excuse of being too busy, as Anne had proved with her patient, conceivably the word would lose its dominance and become forgotten or passe.
Wouldnt it be wonderful, Anne mused, if nurses everywhere could expand and grow in their practice, utilizing empowering and nurturing words until they, too, became habit?
Diane Goodman, RNC, APRN, BC, CCRN, is a clinical nurse specialist at Advocate Condell Medical Center in Libertyville, Ill.


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Orange Bird Bemoaning
Ever since the 2012 season when the Baltimore Orioles decided to adopt their fresh logo, the New Cartoon Bird, the O's have had a shocking reversal of opinion: They really want to win. Like, they actually think they can. Your end result is an Orioles team heading into the 2014 season with two fewer draft picks and two new stars to sharpen their teeth. They want to compete. They can compete. They will compete.
But that doesn't mean they're a championship-level team or even a synch to make the postseason. The Orioles instead are on the fringe of being a playoff team, but even that will be very difficult for them in 2014, thanks to, yes, competition.
The Orioles look more like that prototypical 85-win ballclub. They've got a good number of stars, they excite, and they're one of the best teams in their league in at least one major category. The Baltimore Orioles' offense, despite some of their hitters being overrated guys who don't get on base enough—their only regular player in 2013 who got on base more than .330 was Chris Davis—is pretty solid. As a team, they slugged .431 last year and topped Major League Baseball by a mile in homeruns (212). Say what you want about the Orioles' inability to get on base, they made sure to get their money's worth in automatic run-scoring home runs, one of the best cures for an impatient team.
Only four other teams in the Major Leagues scored more runs than the Orioles in 2013, and you would expect Buck Showalter's boys to crush and slug their way into the top 25 percent of runs scored this year, as they replaced Nate McLouth's weak bat with Nelson Cruz, who, despite his defensive troubles and questions about how he will play following his 50-game performance-enhancing drug suspension, is a steal at $8 million. Cruz will reap his value if he even hits 20 home runs in hitter-friendly Camden Yards.
But the pitching hurts Baltimore a lot too. With Ubaldo Jimenez, their rotation gets a boost, as long as he is more like the Jimenez in his later Cleveland and Colorado Rockies days, but the rotation takes a diagonal dive after that. Chris Tillman and Miguel Gonzalez are only slightly above average, clocking in ERA+s of 113 and 111, respectively, while watching 57 combined baseballs fly out of the park. Wei-Yin Chen pitches like a number four starter, and Bud Norris simply is penciled in the rotation so the Houston Astros can get some laughs with their stolen prospects.
The former savior of an Orioles bullpen also is not dominant, only having two—Darren O'Day and Tommy Hunter—excellent relief pitchers. Ryan Webb and his 2.91 ERA, with a pretty unremarkable Miami Marlins defense behind him, gives Baltimore some breathing room, but the loss of a guy who saved 101 games the last two years will always make a club backtrack. Overall last year, the O's were in the bottom ten in the Major Leagues in ERA, quality starts, WHIP, and batting average against. Or in other Baltimore translations: Thank goodness for that offense!
The O's can live on offense and an OK bullpen and rotation and get over .500, but the most substantial issue with the Orioles' semi-all in plan is their competition. The American League is ridiculously stacked right now, especially in, yes, oh, hey, the American League East. There are three serious—and I mean serious—pennant contenders outside of the Orioles' division that should finish with better records than the O's: the Oakland Athletics, Texas Rangers, and Detroit Tigers.
Oakland quietly had one of the best off seasons in the Majors. Through trades and, for most teams, spare change, the Athletics made their bullpen even better. Yep, you read that correctly. The Ryan Cook-Sean Doolittle-Luke Gregerson combination should dominate baseball, a harmony of relievers each with a high ERA+. Combine that with Jim Johnson taking over the closer duties, striking out more batters and moving from the familiar hitter-friendly Camden Yards to the O.co Coliseum, and the A's might just have the best relief core in the Majors. But the Orioles? Well, OK is only so effective compared to that, and they probably don't have the control the Athletics' relievers have.
Bolstering those late-inning arms is a promising rotation with the likes of Sonny Gray, he-who-matches-Justin-Verlander-in-postseason-duels, and Scott Kazmir. Gray, despite not pitching a lot in 2013, has a high ceiling and a strong strikeout rate. And Kazmir, despite his unpleasant WHIP, limits home runs, and with the help of the Coliseum, should have an even better 2014. That's a rotation that is better than the Orioles' starting core and has much more upside. Thanks to their backend of the rotation having more life than Baltimore's, Oakland figures to be a better starting pitching team over the course of the regular season.
The Athletics and the Orioles stack up pretty closely on offense, interestingly enough, relying more on home runs than getting on base, and having one Most Valuable Player candidate lead the rest. Both teams were also in the top five in wRC+ (Weighted Runs Created+), but the A's drew more than 150 more walks than the Orioles last season, so they are more likely to continue their offensive prowess in 2014 with mostly the same players. But even if we were to be nice and deem the offensive comparison as a draw, the A's beat the Orioles in pitching, and probably defense too. Overall, the Athletics have a much more balanced team than Baltimore.
The Rangers field a pretty similar team as Oakland. Their pitching is one of the best in the American League, despite contending with the ban box that is the now-Globe Life Park in Arlington and despite Derek Holland's dog hurting them. A healthy Matt Harrison and Alexi Ogando give the Rangers good command and tough options in the middle of the rotation; Martin Perez could be a star; and Yu Darvish's billion strikeouts-per-nine innings makes him a much better ace than Jimenez, and probably a few Orioles' starters put together. From one to three—and even four—in their rotation, the Rangers are solid, unlike the Orioles, and they will likely get more run support this season than they did in 2013. Prince Fielder has too many spectacular seasons under his belt to panic about his production, especially since 40 home runs will be easy for him in Arlington. The protection he and Adrian Beltre give each other is strong, and makes the Rangers' offense potent enough that their opponents can't yawn when they see them.
The Orioles still probably have a better offense, but they lose again to the Texas bullpen. You can't blame them, of course, when they have to compare against a bullpen with two relief pitchers with ERA+s above 200. Tanner Scheppers and Neal Cotts quietly shredded AL offenses in 2013, and Robbie Ross and Jason Frasor were no slouches either. Even if Neftali Feliz can't find his form again, those four beat out Hunter, Webb, O'Day, and Brian Matusz any day. Chalk that up as another loss for the Orioles.
But if that's a mismatch for the Orioles, than what are the Tigers in the eyes of Orioles' fans? Detroit is automatically better than the Orioles in hitting and pitching. The Tigers were second to only than the Boston Red Sox in terms of offense last year, ranking in the top two in runs scored, batting average, OBP, and slugging percentage. Their lineup is simply more complete and less overrated than the Orioles'. The difference in starting pitching is laughable; the Tigers have the deepest rotation in MLB, even after trading away Doug Fister for a bag of tricks. Their bullpen may be a concern at times, but Luke Putkonen and Bruce Rondon will be regulars in 2014, two of the Tigers' best secret weapons last year with strikeout-per-nine inning rates of at least 8.5. With Joe Nathan closing games, the Tigers should do just fine in the bullpen to clean up what few messes their offense and rotation will leave them. That's quite unlike the Orioles, who are often in gunk and have to walk the tightrope more often than an excellent team should. The Tigers even project to be a better defensive team this season, a year after their Defensive Runs Saved was -66.
Considering that any three of those teams will give the O's standings troubles for the AL Wild Card spots—Oakland and Texas more likely than the Tigers, who will surely clinch a playoff spot via the American League Central—and since there can only be two division winners outside of the East, the O's will realistically have to battle their division foes for the last Wild Card spot.
Oh hey, about that.
Let's put this into perspective: the American League East is again the best division in MLB. There are three—maybe even four—playoff-level teams outside of Baltimore in the AL East, and the O's may only be better than two of them.
No, not the Red Sox or the Tampa Bay Rays. The Rays are a much more balanced team than the Orioles at the moment. After years of shoving by the league with their pitching, the Rays can actually hit and field; they're in the top ten in both categories, and had the second-best wRC+ in either league last season. They may not have slugged like the Orioles but they got on base. Over the course of a whole season, the Rays' offense will match up well with the Orioles.
They'll also save a lot more runs than the O's will, thanks to their pitching. From top to bottom, the Rays have the best rotation in the AL East. They don't have a single bad starter. David Price, Matt Moore, Jeremy Hellickson, Chris Archer, and Alex Cobb strike out a ton of batters. The depth difference between them and Baltimore will give Tampa Bay many more wins than the O's will get, and the Tampa Bay bullpen, anchored by Grant Balfour, is at worst just as good as Baltimore's pen.
Even though the Red Sox's rotation isn't nearly as scary as Tampa Bay's, their pitching department can run circles around Baltimore. The Boston bullpen looks poised to tear apart AL hitters again this year. Koji Uehara will play the entire year as the closer. It would be unfathomable if he walked only nine hitters like he did in the 2013 regular season, but even a fair regression would leave Uehara as a lights out closer. Behind him, the bullpen doesn't get much thinner; Craig Breslow's 1.81 ERA was almost as spectacular as Uehara's, and Junichi Tazawa had a strikeout-to-walk ratio of six. ESPN's Fantasy Projections aren't kind to Edward Mujica, but as long as doesn't get gassed like he did down the stretch for the St. Louis Cardinals, Mujica should be a good complement for the Red Sox thanks to his stellar walk rate of two percent in 2013, something that shouldn't revert horribly against AL hitters.
The Boston rotation is a workhorse overall; Jon Lester is back to his ace-like self, possibly no more evident than how he mowed down the Cardinals in the World Series and built a legitimate World Series MVP case. John Lackey likely won't have a down year, as he's healthier, and even at age 35 he should sit well as the number three starter because of his control. Despite being the best pitcher in the American League before his neck and shoulder bugged him last year, Clay Buchholz's history of injuries pushes the Boston rotation back, but there's enough depth there to keep the Red Sox at the top and let their number one offense outscore just about everyone else in the Bigs. Because even without Jacoby Ellsbury, the Red Sox's across-the-board top lineup is about the same and might only get better if Jackie Bradley Jr. and Xander Bogaerts hit.
Boston and Tampa Bay will probably fight out for the division title again, leaving the other to snatch a Wild Card berth. The math then puts the O's immediately in a grave; one Wild Card spot taken by an AL West club, and another by an AL East team. But let's entertain the possibility that both Wild Cards come out of the East. Surely, the Orioles can finish with a better record than the New York Yankees and the Toronto Blue Jays, right? Ehh, that's not clear.
That's because the Yankees are the Orioles' biggest thorn. Both clubs are close. Offensively, the O's still trump the Robinson Cano-less Yankees in home runs and should end up scoring more runs than them. The Yankees, after all, will rely on a 40-year-old Derek Jeter and a Mark Teixeira whose average and on-base skills have trended downwards over his tenure with the Yankees, to give them the extra push. Brian McCann and Jacoby Ellsbury should give the Yankees more balance and extra pop, but the entire team will probably come up a shade short compared to the Orioles' behemoths.
But the Yankees' pitching, oddly enough, will keep them in the Wild Card race. Even if Masahiro Tanaka's arm only lasts for half a season, the depth the Yankees have is actually not bad. Hiroki Kuroda, even at 39 and even if he hits the wall he's been expected to hit, is better than most of the Orioles' starters. For a full season, Ivan Nova is fine as a number three or four starter, as he's averaged a 0.9 homerun-per-nine innings rate for his entire career. And CC Sabathia should be a good enough run preventer now that he is fully over his elbow surgery. If the Yankees had one more really good relief pitcher to back up David Robertson, then that would probably match the Baltimore bullpen to the tee. Regardless, though, the Yankees will be at Baltimore's heels all season long, especially if one of their bullpen prospects converts the talk into results in 2014.
But even the Toronto Blue Jays might make the Orioles sweat. As ESPN's Jayson Stark argues, the Jays still have talent on their team, and, unlike early last year, are healthy. J.A. Happ and Brandon Morrow, two of the starters expected to give the Blue Jays the depth to survive and thrive in the East, started a combined 30 games in 2013. The only position players to log at least 120 games were Edwin Encarnacion, Adam Lind, and J.P. Arencibia—who now is not with the team—according to Stark. Jose Reyes's ankle was throttled sliding into a base, Jose Bautista injured his hip stepping on home plate, and Brett Lawrie got injured in the World Baseball Classic. The end result was Reyes posting a .353 OBP in less than 100 games and Bautista hitting 28 home runs. If everyone stays on the field, the Blue Jays should hit and hit for power again. Their bullpen has been boringly good and likely will stay that way, so if the Blue Jays' rotation remains on the mound and reclaims the hype they had one year ago, then Toronto could make a run at, yes, a Wild Card spot, and, yes, frustrate the Orioles.
There are a dozen Wild Card scenarios that could play out in the American League, but when there's seven—maybe even eight—playoff-level teams fighting for five postseason spots, then the odds aren't in the favor of a team with as many flaws as the Orioles. They haven't done enough with their pitching to take themselves to that next level—that Red Sox, Rays, Tigers, A's, Rangers level—to be a synch for the postseason. The Orioles want to compete. They can compete. They will compete.
But that's not unlike six other teams with better opinions.


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Snow Blizzard and Travel Back to NY
Posted by Shane
On the last day of skiing in Park City, Utah was great. Though I am a day last posting this post, I was way tired after doing everything I had to do to travel back to NY. So let's get right too it.


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Reports > Select Report Type
- To start generating reports, you will have to choose if it's going to be a task-, resource,- or project-driven. Select an option from the left. 'Task-driven' is applied by default.
Task-driven reports will build selected report fields/information around tasks. That means you'll see This option gives the most information and is applied by default. A 'task-driven' report will look like this.
Resource-driven reports
Project-driven reports


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There is no doubt that both bankers and politicians could improve matters. They could all learn some vocal discipline, and just shut up about the exchange rate. The spectacle of one lot heaping public blame on the other has traders rubbing their hands in glee before they hit the sell button. And Europe's political elite could make a big difference with a commitment, however symbolic, to the sort of structural economic reforms that are no-brainers on this side of the Channel - lower taxes on jobs, say, or longer store opening hours. It is hardly radical stuff.
The really unexpected aspect of Euroland's currency crisis, however, has been the weakness of two of the core economies, Germany and Italy. This had not been factored in by the financial markets ahead of the launch, so the conflict between the need for lower interest rates in these two countries, in contrast to the booming peripheral economies, has created uncertainty about interest rates and growth prospects.
However, business cycles do turn. The euro will not be weak for ever. And the weakness is overdone precisely because the markets and pundits are focussing on the bad news. The rest of Euroland is doing pretty well. Sentiment about the currency could go into reverse - especially if the bankers and politicians decided to help rather than hinder it.
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- Banking
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Shortland Court Motel provides 4 Star Qualmark, luxury accommodation for discerning travellers to the Coromandel Peninsula and Thames.
Our "high-speed broadband wi-fi" allows you to keep in touch while on the move.
Thames is the main commercial centre for the Coromandel Peninsula and the adjacent region. An ideal place to base a holiday.
Founded in 1867 during the New Zealand goldrush, Thames is truly a colonial town. The Gold rush and boom days have left the town with a unique character for the visitor to explore and enjoy.
Shortland Court is one the finest Motels in Thames and on the Coromandel Peninsula


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I'm the Liver ´2015
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- Writers: John Wells, Paul Abbott
- Stars: Cameron Monaghan , Emma Greenwell , Emma Kenney , Emmy Rossum , Ethan Cutkosky , Jeremy Allen White , Joan Cusack , Justin Chatwin , Laura Wiggins , Michael Patrick McGill , Noel Fisher , Shanola Hampton , Steve Howey , William H. Macy
Fiona is officially off house arrest while Lip starts his first day of work for Tommy. But manual labor turns out to be harder than Lip thought and the brutal hazing from his co-workers doesn't help. Sheila considers an offer from two lesbians who want to buy her home. Frank tries to talk her out of it and begins warning everyone of the neighborhood's impending gentrification. Also, the father of boy whose liver Frank received invites Frank to a special father's day dinner with all the other organ recipients, which Sammi ends up crashing, further enraging Sheila. Meanwhile, a manic Ian plans his revenge with Mickey and Mandy against a homophobic military funeral protest. Fiona confronts Sean about her feelings for him. Kev bonds with Svetlana. And Debbie continues to struggle with her friends and boys.
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SCXA encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. Additionally we are shipping Scleraxis Homolog A (Mouse) Proteins (3) and and many more products for this protein.
Showing 10 out of 21 products:
Human Polyclonal SCXA Primary Antibody for WB - ABIN654398
Furumatsu, Shukunami, Amemiya-Kudo, Shimano, Ozaki: Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. in The international journal of biochemistry & cell biology 2009
Show all 3 references for ABIN654398
The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis (show SCX Antibodies) to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Antibodies)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes
Cardiac fibroblast phenotype regulation by scleraxis (show SCX Antibodies).
scleraxis (show SCX Antibodies), a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of mesenchymal stem cells towards tenocyte differentiation.
deletion of Scx (show SCX Antibodies) led to impairments in enthesis structure.
several mRNAs are affected by alternative splicing events in the absence of Scx (show SCX Antibodies), suggesting additional roles in post-transcriptional modification.
Expression and function of scleraxis (show SCX Antibodies) in the developing auditory system.
These studies identify an important role for Scx (show SCX Antibodies) in regulating proteoglycans in embryonic and mature valve cells.
paratenon cells, which normally do not express Scx (show SCX Antibodies), respond to injury by turning on Scx (show SCX Antibodies) and assembling matrix to bridge the defect
Smad3 (show SMAD3 Antibodies) binds Scleraxis (show SCX Antibodies) and Mohawk and regulates tendon matrix organization.
Findings suggest a modular model for bone development, involving a distinct pool of Sox9 (show SOX9 Antibodies)- and Scx (show SCX Antibodies)-positive progenitor cells that form bone eminences under regulation of TGFbeta (show TGFB1 Antibodies) and BMP4 (show BMP4 Antibodies) signaling
This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction.
basic helix-loop-helix transcription factor scleraxis
, class A basic helix-loop-helix protein 41
, class A basic helix-loop-helix protein 48
, class II bHLH protein scleraxis


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Since California-based conservative writer Joseph Farah founded it in 1997, WorldNetDaily, now simply known as WND, has emerged as a leading online platform for conspiracy theorists, Tea Party activists and End Times prophets. The site, particularly its reporter Jerome Corsi, championed discredited "birther" claims about President Obama's birth certificate, birthplace, parents, sexuality and marriage. At one point, WND worked with Donald Trump to spread the false allegations. Often, WND will try to present conspiracy theories by saying that they are only "asking the question"—a tactic also embraced by Trump—and will source its "reporting" to website commenters. WND publishes columns from far-right activists such as Pat Buchanan, Ann Coulter, Pat Boone, Chuck Norris, Larry Klayman, Linda Harvey and Erik Rush.
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May 15, 2017 4:10 pmTrump Official Warned That 'Satanic' Elites Run The World, 'Islamic Invasion' Creating 'Mongrel Culture'
May 11, 2017 4:21 pmAnti-Vaccine Site Mocks 'Muslim Measles'
April 14, 2017 12:08 pmJohn Guandolo: Start 'Locking Up' CAIR Officials
April 11, 2017 4:58 pmDavid Kupelian: God Intervened To Prevent Millions Of Americans From Going 'Completely Mad' Under President Hillary Clinton
March 9, 2017 3:24 pmFar-Right Pundit Urges Trump To Prosecute Obama For Treason
March 1, 2017 12:55 pmLinda Harvey: 'Pro-Gay Messages' In Schools 'Resemble The Grooming A Pedophile Does Before Molesting A Child'
March 1, 2017 12:00 pmJoseph Farah: Put Trump's Face On Mount Rushmore
February 7, 2017 5:02 pmRight Wing Bonus Tracks – 2/7/17
February 6, 2017 12:35 pmJesse Lee Peterson: If There Were No Black People In America, We Wouldn't Have As Many Murders And Riots
February 2, 2017 11:45 amJerome Corsi: From Trump Conspiracy Theorist to Trump's Conspiracy Theorist


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Surprisingly, I was second up today, my roommate Steve Marsh ding the honours and allowing me an extra ten minutes in bed by taking to the shower first… On for day 2 of the Business EVOlution Tour 2006!
Everyone piled on the tour bus in time for 7:30, my phone call to the recent recruits from the Microsoft graduate programme, James Senior and Matt McSpirit at 6:50 reminding them to be there for 7:00 was well worth it for the laugh 🙂 Welcome to the new world of work!
Off to the London Kensington Odeon we went to setup
Today's host was Steve Clayton backed up by James Akrigg and Matt McSpirit.
Act 1 of the tour focuses on 'Changes', a whistle stop tour of some of the fantastic new capabilities of Windows Vista and the 2007 Microsoft Office System. From Superfetch which can help speed up application launches based on daily/weekly learnings from user selection of applications chosen on startup, through the new Start Menu enhancements incorporating pervasive search capabilities onto ReadyDrive, Windows Aero, the Office Ribbon and Minibar back to Windows Vista graphics capabilities and DirectX 10, finishing with Search Explorer covering filters, live preview, advanced search and saved searches…phew! So, eleven down, only another nine to go and with time running short, the Vista games do nicely..!
The second and third acts went down a treat also, maybe another preview tomorrow. If you haven't yet registered and want to attend, have a look here to find a venue near you soon.
Look forward to seeing you there…Ciao for now 🙂


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Hows exciting!! I'm a DDP Today! I don't have too much in my diary as of right now, because I'm still little and new, but you can be sure that I'll be posting lots more in time! :D
My sisfur and brofur and I have lots of things to share, and videos to post.. so stay tuned! :D
Stop and Smell the flowers!
I loves to sing sing sing! Momma says I'm a talker and a singer :D I will just all of a sudden start Woo'ing.. and then that gets my brofur Colossus going too! BOL! Colossus wasn't much of a "talker".. just every once in awhile.. until now! Now he likes to back me up when I'm singing. Tiki usually just looks at us like we are crazy (but I have heard her woo'ing away at times too, so don't let her fool you!).
Today Momma was woken up by me Woo'ing at the top of my lungs. Nothing wrong.. just me wanting to sing in the opera :D I think I'd be really great in the Opera.
Woooooo Wooooooo !
My name is Magneto, and I am brand new! Not just to my new family, but to the entire Worlds!
I came to my family is an adventure in it's self. My new Daddy was talking with one of the peoples that works for him, and the peoples was saying that he had gotten a little husky pup, but couldn't keep him. He gots the puppy for his girlfriend, but they broke up, she didn't wants the puppy and he couldn't keeps the puppy where he was living. :( Not the best of situations at all. Daddy talked to Momma and she said that they could take foster the puppy until a home was available.. she just wasn't ready for a new puppy.. but then she saw me, and it was love at furst sight. :D So they ended up just keeping me. Momma said it had to be the record breaker for fastest foster failure ever.. BOL!
I am still adjusting to my new family. My big sisfur Tiki welcomed me in right away, after making sure that I knew SHE was the boss (after Momma, Daddy and the human brofurs). Colossus bullied me a lot the furst couple of days, but after being here for more then a week, he isn't as rough as he once was, and we get along well (at least, when he's not trying to run me over.. BOL!)
I'm sure I'll be writing more in the blog that us pups have The Pups Blog!
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- We offer a large range of farm equipment and light construction machinery. Many items are designed and assembled in our premises by our fully qualified mechanics.
- Need a high pressure water pump? At Cross Country we can set up high pressure positive displacement water pumps specifically designed to meet your needs. Be it diesel, petrol or electric and pumping to heights up to 300 metres.
- Cross Country - owned by Bruce and Sheryl Finan are the sole distributers for DEK, Turf Mate and Seaflo products.
- For over 10 years we have been supplying New Zealand and many overseas countries with our products. All carry 12 months warranty within New Zealand.
Phone 0800 847 2052 for more information on any of our products
DEK LS-30 Vertical / Horizontal 30 Ton Petrol Powered Log Splitter
It was so popular we have decided to extend the offer! Buy this log splitter and get a FREE upgrade to a DEK 13hp Petrol Engine!!
12 Months Waranty.
NZ assembled, pre-filled with hydraulic oil (25 litres valued at $250), don't waste your time putting them together, FULLY ASSEMBLED READY TO USE !
Highly portable, and compact, with 8" wheel rims for easy transportation
DEK BD-450 Positive Piston Displacement Pump is purpose built for pumping, spraying, irrigating large areas, greenhouse irrigation, vineyards, orchards, fertiliser or weed killers, frost protection, boom spraying, keeping the tanks full or pumping water for long distances and heights
Davies Style Pump Featuring:
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- 3 pistons for smooth pressure and flow
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- Oil level indicator
Technical Features - Pump:


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Bacon Canvas Tote Bags are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Bacon Canvas Tote Bag for a special occasion, give a Bacon Tote Bag as a present or need to represent with a funny Custom Bacon Bag during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Bacon Canvas Tote Bag for you! Even if it turns out you can't find the right Custom Bacon Bag with the perfect design for your mother, father or children (or friends!); Idakoos offers all of its Bacon Canvas Tote Bags as Custom Bacon Tote Bags. Personalize any Bacon Canvas Tote Bag the way you want to ensure the perfect gift.
Showing 1 - 24 of 90 Canvas Tote Bag


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The 14-year-old was a passenger in one of the cars - a grey Nissan Sunny - which collided with a red Nissan Micra in Enfield on New Year's Eve.
Scotland Yard said that the two cars were side-by-side when they hit each other.
The girl suffered multiple injuries and is in a critical condition at a London hospital. Her parents were at her bedside.
Police called to the scene of the crash at The Ridgeway at 8.20pm on Wednesday found the Sunny on its side and the Micra overturned. Both were stolen from the Enfield area - the Sunny on Boxing Day and the Micra on New Year's Eve.
Three youths, two aged 17 and a third 16, and two girls, both aged 14, were held by police at the scene and later arrested and interviewed.
Police are still searching for a man believed to have been the driver of the Sunny. He is described as white and aged in his early twenties.
A Scotland Yard spokesman said: "We believe there were three passengers and a male driver in one car and two passengers and a male driver in the other car.
"It is not clear which of the cars carried the three passengers and which the two.
"They were in a side-to-side collision. It is possible they were racing, but that is speculation at this early stage."
Investigating officer Detective Sergeant Chris Krelle of Edmonton-CID said: "A 14-year-old is critically ill in hospital and it is vital that we speak to the missing driver.
"Leaving the scene of a road traffic collision is always pointless. Someone knows where he is. It would be better for everyone if he hands himself in so that we can investigate the full circumstances of this incident."
The five people arrested after the crash were bailed to return to police stations in February.
Anyone with information should call Edmonton CID on 020 8345 4473 or Crimestoppers anonymously on 0800 555 111.Reuse content


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Six incredible brands have joined forces for this incredible giveaway geared toward our fans who love to get out on the water and fish. The Tarpon in Tampa trip has been in the works for months, and once we got the crew on board and nailed down a date with our fishing guide, we couldn't wait to get the word out about the contest.
South Texas, to the outdoorsman, is a landscape that is distinctly, well, "South Texas." The mystique and history about that part of the country and the sporting pursuits therein cannot be found elsewhere.


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Old games in maximum quality on Radeon HD 5870
Ati's Radeon HD 5870 delivers enough power to display old games at an up to now unknown quality. With 55 screenshots PC Games Hardware shows what 8x Sparse Grid Supersampling Anti Aliasing is looking like.
One of the features offered by the Radeon HD 5000 series is the ability to display eightfold Sparse Grid Supersampling Anti Aliasing. This kind of edge smoothing is the best which is currently delivered by modern graphics cards: The whole frame, including the textures and pixel shader effects is smoothed - in contrast to "normal" Multisampling Anti Aliasing where only the polygon edges are dealt with. PC Games Hardware used a HD 5870 to check the mode in several games. Of course we had 8x SGSSAA active all the time and used an appropriate Texture LOD of -2 (for best texture sharpness).
Radeon HD 5870: 8X SGSSAA in action
For PC games Max Payne 2, Bioshock (DX9), Fear, Serious Sam 2 and Flatout: Ultimate Carnage are already a little older. As owner of a Radeon HD 5000 you best use the spare performance if you activate the mentioned Anti Aliasing in the Catalyst control Center. At 1680 x 1050 pixels - which is one of the most popular resolutions for gaming - all the tiles are running smoothly.
The 55 screenshots in our gallery demonstrate the excellent quality of this AA mode. What do you think about this feature? Tell us in the comments.
PC-Spiele 2017: Games-Liste mit Release-Terminen [Update: Far Cry 5, FIFA 18, PES 2018, The Crew 2]


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Web Design and Hosting
Web design and hosting have been the popular online jobs we have today. These online jobs have include the web design in their works. The task is just simple for those who are well informed in the world of internet and computer. Those people who taken IT courses are the ones who were qualified in the certain job that was mentioned. But many people and students who are not enrolled in the computer course have also the ability to do some web designing and hosting. The first world countries who were well fed with high technology have been the top finders for web designers that will help the main admin to develop a websites for a variety of usage.
Some people have misunderstood the web designing as just simple work and that it effortless to do. The web designing requires a lot of knowledge in the internet and must be handled properly because of something goes wrong it will be very difficult to go back and correct then certain mistake. Some experts have said the web designing and hosting is only for those people who are very creative and has a knowledge in the web designing. During school days, we can remember that we have that computer subject that we are required to enroll at. Check out this site for more details about web design and hosting.
The computer subject have given us the introduction about the computer world and how things works on their own. We have encountered the web designing which I think is really a difficult task because you will have to deal with codes and certain areas that involves web designing. The task involves many things like decoding and encoding things that will be used for the website. Once the website is done, the web designer will really feel happy and satisfied because many people will be able to see his work. Companies have been hiring certain web designers to build and enhance the website of their company. To learn more about web design and hosting, you can visit http://www.huffingtonpost.com/adda-birnir/5-killer-web-design-tips-_b_4038652.html.
Many companies who did this are usually the new ones that need to be publicize and inform the public about their products. It also important for these companies to have a nice impact to market. Many companies utilizes the use of technology and uses the internet and the social media for their work. And social media involves these websites by new companies which will be showcasing their products. The impact of the use of websites for the companies have also brought them positive effects to their companies. Visit website if you have questions.


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I can't say I ever imagined I'd end up on food stamps — both my wife and I have college degrees. But after moving to North Carolina a few years ago, the economy took a turn for the worse, and brought our successful online business with it. I ended up having to take a job that paid only minimum wage. I was lucky to have any work at all, but minimum wage isn't enough to support a family of four. We tried to trim our budgets anywhere we could, but we still couldn't find the money we needed to feed our kids. Thankfully, we were able to get food stamps. They enabled us to literally survive during this difficult time. I don't like to think about what we would have done without them. My kids would have just gone hungry. It would have been horrible.
A few months after working for minimum wage, I was offered an opportunity to move up. I now have an amazing job that pays enough to support my family. It's incredible how far we've come from where we started. I don't think we'd be here today if it wasn't for food stamps. For us, they were a stop-gap measure; they prevented us from falling so deep into poverty that we couldn't get out. And I think that's what food stamps are for most people. They are a critical resource that help families like mine get back on their feet again, and on the road to a better life.
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