text:
Introduction to Bioinformatics. What is Bioinformatics?. on molecular. NIH – definitions .
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Introduction to Bioinformatics
What is Bioinformatics?
on molecular
What is Bioinformatics? - Research, development, and application of computational tools and approaches for expanding the use of biological, medical, behavioral, and health data, including the means to acquire, store, organize, archive, analyze, or visualize such data.
What is Computational Biology? - The development and application of analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological, behavioral, and social data.
Large databases that can be accessed and analyzed with sophisticated tools have become central to biological research and education. The information content in the genomes of organisms, in the molecular dynamics of proteins, and in population dynamics, to name but a few areas, is enormous. Biologists are increasingly finding that the management of complex data sets is becoming a bottleneck for scientific advances. Therefore, bioinformatics is rapidly become a key technology in all fields of biology.
The present bottlenecks in bioinformatics include the education of biologists in the use of advanced computing tools, the recruitment of computer scientists into this evolving field, the limited availability of developed databases of biological information, and the need for more efficient and intelligent search engines for complex databases.
The present bottlenecks in bioinformatics include the education of biologists in the use of advanced computing tools, the recruitment of computer scientists into this evolving field, the limited availability of developed databases of biological information, and the need for more efficient and intelligent search engines for complex databases.
Molecular Bioinformatics involves the use of computational tools to discover new information in complex data sets (from the one-dimensional information of DNA through the two-dimensional information of RNA and the three-dimensional information of proteins, to the four-dimensional information of evolving living systems).
Bioinformatics (Oxford English Dictionary):
The branch of science concerned with information and information flow in biological systems, esp. the use of computational methods in genetics and genomics.
The field of science in which biology, computer science and information technology merge into a single discipline
collect molecular data:
DNA & Protein sequences,
gene expression, etc.
Study biological questions by analyzing molecular data
Computer scientists
(+Mathematicians, Statisticians, etc.)
Develop tools, softwares, algorithms to store and analyze the data.
Some biological background….
A biologist
The hereditary information of all living organisms, with the exception of some viruses, is carried by deoxyribonucleic acid (DNA) molecules.
2 purines:
2 pyrimidines:
adenine (A)
guanine (G)
cytosine (C)
thymine (T)
one ring
two rings
The entire complement of genetic material carried by an individual is called the genome.
Eukaryotes may have up to 3 subcellular genomes:
1. Nuclear
2. Mitochondrial
3. Plastid
Bacteria have either circular or linear genomes and may also carry plasmids
Human chromosomes
Circular genome
Central dogma: DNA makes RNA makes Protein
Modified dogma: DNA makes DNA and RNA, RNA makes DNA, RNA an Protein
Amino acids - The protein building blocks
Any region of the DNA sequence can, in principle, code for six different amino acid sequences, because any one of three different reading frames can be used to interpret each of the two strands.
Protein folding
A human Hemoglobin:
How does it all looks like on a computer monitor?
A cDNA sequence
>gi|14456711|ref|NM_000558.3| Homo sapiens hemoglobin, alpha 1 (HBA1), mRNA
A cDNA sequence (reading frame)
>gi|14456711|ref|NM_000558.3| Homo sapiens hemoglobin, alpha 1 (HBA1), mRNA
A protein sequence
>gi|4504347|ref|NP_000549.1| alpha 1 globin [Homo sapiens]
And, a whole genome…
How big are whole genomes?
What do we actually do with bioinformatics?
Sequence assembly
(next generation sequencing)
Genome annotation
Molecular evolution
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
Smith et al. (2009) Nature 459, 1122-1125
Analysis of gene expression
Gene expression profile of relapsing versus non-relapsing Wilms tumors.
A set of 39 genes discriminates between the two classes of tumors.
(http://www.biozentrum2.uni-wuerzburg.de/, Prof. Gessler)
Analysis of regulation
Toledo and Bardot (2009) Nature 460, 466-467
Protein structure prediction
Protein docking
Luscombe, Greenbaum, Gerstein (2001)
Sanger sequences insulin protein
Watson and Crick DNA model
Dayhoff's Atlas
Sequence alignment
ARPANET (early Internet)
PDB (Protein Data Bank)
Sanger dideoxy DNA sequencing
GenBank database
PCR (Polymerase Chain Reaction)
SWISS-PROT database
Human Genome Initiative
World Wide Web
First bacterial genome
Yeast genome
First human genome draft
Origin of bioinformatics and
biological databases:
The first protein sequence reported was that of bovine insulin in 1956, consisting of 51 residues.
Nearly a decade later, the first nucleic acid sequence was reported, that of yeast tRNAalanine with 77 bases.
In 1965, Dayhoff gathered all the available sequence data to create the first bioinformatic database (Atlas of Protein Sequence and Structure).
The Protein DataBank followed in 1972 with a collection of ten X-ray crystallographic protein structures. The SWISSPROT protein sequence database began in 1987.
as of August2011:
Eukaryotes 37
Prokaryotes 1708
Total 1745
What can we do with sequences and other type of molecular information?
Open reading frames
Functional sites
Structure, function
TF binding site
Start Site
Ribosome binding Site
ORF = Open Reading Frame
CDS = Coding Sequence
Comparing ORFs
Identifying orthologs
Inferences on structure
and function
Comparing functional sites
Inferences on regulatory
Similarity profiles
Researchers can learned a great deal about the structure and function of human genes by examining their counterparts in model organisms.
Alignment preproinsulin
Xenopus MALWMQCLP-LVLVLLFSTPNTEALANQHL
Bos MALWTRLRPLLALLALWPPPPARAFVNQHL
**** : **.*: *:..* :. *:****
Xenopus CGSHLVEALYLVCGDRGFFYYPKIKRDIEQ
Bos CGSHLVEALYLVCGERGFFYTPKARREVEG
***************:******* :*::*
Xenopus AQVNGPQDNELDG-MQFQPQEYQKMKRGIV
Bos PQVG---ALELAGGPGAGGLEGPPQKRGIV
.**. *********
Xenopus EQCCHSTCSLFQLENYCN
Bos EQCCASVCSLYQLENYCN
Ultraconserved Elements in the Human Genome
Gill Bejerano, Michael Pheasant, Igor Makunin, Stuart Stephen, W. James Kent, John S. Mattick, & David Haussler (Science 2004. 304:1321-1325)
There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in RNA processing or in introns or nearby genes involved in the regulation of transcription and development.
There are 156 intergenic, untranscribed, ultraconserved segments
Supporting evidence
Junk is real!
Genome-wide profiling of:
• mRNA levels
• Protein levels
Co-expression of genes
and/or proteins
Identifying protein-protein interactions
Networks of interactions
Understanding the function of genes and other parts of the genome
Assign structure to all
proteins encoded in
a genome
What is a Database?
A structured collection of data held in computer storage; esp. one that incorporates software to make it accessible in a variety of ways; transf., any large collection of information.
database management: the organization and manipulation of data in a database.
database management system (DBMS): a software package that provides all the functions required for database management.
database system: a database together with a database management system.
Oxford Dictionary
Flat-file database (« flat file, 3 entries »):
Accession number: 1
First Name: Amos
Last Name: Bairoch
Course: Pottery 2000; Pottery 2001;
Accession number: 2
First Name: Dan
Last name: Graur
Course: Pottery 2000, Pottery 2001; Ballet 2001, Ballet 2002
Accession number 3:
First Name: John
Last name: Travolta
Course: Ballet 2001; Ballet 2002;
Relational database (« table file »):
Literature Databases:
Bookshelf: A collection of searchable biomedical books linked to PubMed.
PubMed: Allows searching by author names, journal titles, and a new Preview/Index option. PubMed database provides access to over 12 million MEDLINE citations back to the mid-1960's. It includes History and Clipboard options which may enhance your search session.
PubMed Central: The U.S. National Library of Medicine digital archive of life science journal literature.
OMIM: Online Mendelian Inheritance in Man is a database of human genes and genetic disorders (also OMIA).
A search by subject:
"mitochondrion evolution"
query box and hit the "Go" button
Related Items
A search by authors:
"Esser" [au] AND "martin" [au]
A search by title word:
"Wolbachia pipientis" [ti]
Start working:
Search PubMed
cuban cigars
cuban OR cigars
"cuban cigars"
cuba* cigar*
(cuba* cigar*) NOT smok*
Fidel Castro
"fidel castro"
"Details" and "History" in PubMed
"Details" and "History" in PubMed
MIM Number Prefixes
* gene with known sequence
+ gene with known sequence and phenotype
# phenotype description, molecular basis known
% mendelian phenotype or locus, molecular basis unknown
no prefix other, mainly phenotypes with suspected mendelian basis
OMIM search tags
All Fields [ALL]
Allelic Variant [AV] or [VAR]
Chromosome [CH] or [CHR]
Clinical Synopsis [CS] or [CLIN]
Gene Map [GM] or [MAP]
Gene Name [GN] or [GENE]
Reference [RE] or [REF]
Start working:
Search OMIM
How many types of hemophilia are there?
For how many is the affected gene known?
What are the genes involved in hemophilia A?
What are the mutations in hemophilia A?
Online Literature databases
1. How to use the UH online Library?
2. Online glossaries
3. Google Scholar
4. Google Books
5. Web of Science
How to use the online UH Library?
Online Glossaries
Bioinformatics :
Molecular Evolution:
Biology dictionary:
Other glossaries, e.g., the list of phobias:
4. Google Scholar
What is Google Scholar?
Enables you to search specifically for scholarly literature, including peer-reviewed papers, theses, books, preprints, abstracts and technical reports from all broad areas of research.
Use Google Scholar to find articles from a wide variety of academic publishers, professional societies, preprint repositories and universities, as well as scholarly articles available across the web.
Google Scholar orders your search results by how relevant they are to your query, so the most useful references should appear at the top of the page
This relevance ranking takes into account the: full text of each article. the article's author, the publication in which the article appeared and how often it has been cited in scholarly literature.
What other DATA can we retrieve from the record?
5. Google Book Search
Start working:
Search Google Books
How many times is the tail of the giraffe mentioned in On the Origin of Species by Mr. Darwin?
6. Web of science


text:
Destined To Fall
by Lady Kelina
Rated: T
Summary: The Last of the Jedi faces a terrible trial and fails, but a greater challenge awaits him.
(Luke Skywalker AU)
AN: All Characters are the property of George Lucas (of course). Please review with any constructive criticism.
Among the Clouds
A piercing scream fills the air. I don't even realize that it is my voice crying out. My cry is caught up in the whipping wind, before dying out into the oblivion that surrounds me. Pain shoots through me, and all I see is the empty air that once held my saber hand. The dark figure presses closer, and in this moment I realize I am going to die.
I fold my injured limb against my chest, willing the pain to subside. How could I have failed? I promised I wouldn't fail. Time freezes, and my mind strays, revealing what has happened. Memory comes to the forefront, and in an instant, I am reliving all that has happened.
"The Force is with you, but you are not a Jedi, yet." Vader had warned me, but I had struck out against his warning. I was proud and arrogant, like Yoda feared, and for that I would die.
"Release your anger, only your hatred can destroy me." No, my anger, my hatred could only destroy myself. I tried to remember what Obi-Wan and Yoda had taught me, but controlling my anger was growing difficult. We fought within the Carbon freeze chamber, and when he fell, I thought, despite all the odds, I might defeat him.
Then I found the shadowed room, where Vader was waiting for me. Against the silhouette of a large window, we fought. In the midst of the battle, debris was sent flying about the room. I knew it was Vader, but I couldn't concentrate to deflect the attack. The debris collided against me before crashing through the window. A strong gust occurred as air poured from the room. I was pulled through window and into the wind tunnel of the inner spiral.
I caught myself on a ledge some ways down, and pulling myself back on to the walkway, I realized that I couldn't win. Despite that, I knew I had to try. Obi-Wan was counting on me. Yoda was counting on me. Even Leia and Han were depending on me. I had to defeat Vader.
Creeping along the walkway, I found my way to another control room, and the sith was again waiting for me. Our blades clash against one another, and while he seemed to gain strength, my own waned. Moving out of the control room, he pressed forward, driving me back toward the walkway's edge. I felt my feet fall from underneath me, as I collapsed to the ground. "You are beaten," Vader announced, pressing his saber toward my face. "It is useless to resist. Don't let yourself be destroyed, as Obi-Wan did."
I lashed back at him, knocking his blade aside. Getting to my feet, I continued to fight. I managed to strike my enemy's shoulder, yet Vader still advanced. I was running out of ground. Stepping out on to the ledge, I knew I was completely cornered. My saber in one hand, I tried to strike back.
That was when it happened. In one swift move, it was over. I cried out, but it was too late. I knew that I had been defeated. I crumpled back, holding my wounded arm against my chest. Moving further away from the platform's edge, I knew my attempt was useless.
That memory brings me abruptly back to the present. The wind is still whipping around me. The pain is still there, yet what I noticed most is the constant shadow of my enemy. Though his blade rests passively at his side, my instinct takes over. I move along the thin ledge, knowing that I'll never survive this.
"There is no escape," the dark voice taunts me, saying what I have already realized. I move back, as far as I can, knowing the fatal blow will strike me at any moment. I reach the edge of the post, I can go no further without falling into an endless abyss.
"Luke," Vader says my name, making my blood boil. "You don't realize your importance. Join me, I'll complete your training."
"I'll never join you!" I roar, rage filling my words. I could never join the sith. I will never become what killed my father.
"If you only knew the power of the dark side," Vader continues. "Obi-wan never told you what happened to your father."
"He told me enough," I counter, clinging to the post with my only hand. "You killed him," I growl, as if the very words would drop Vader where he stands.
Vader's hand is outstretched, reaching for me. "No, Luke, . . . I am your father."
At that moment, I don't feel anything. I'm numb. No, it can't be. Obi-Wan would have told me. "No," I defiantly swear. "I don't believe you."
Vader is unmoved by my doubt, "Search your feelings, you know it to be true."
Unwillingly, I obey, and I find nothing but the damning truth. In that moment, the naïve farm boy is gone, leaving only a memory in his place. If this monster is my father, what am I? Anger swells within me. I know it's true. Somewhere in my very soul, I know, but I will never accept it. I won't give into this. "No," I shout over the whipping wind, "My father was a Jedi, and you're a monster. You are nothing like my father."
Vader says nothing, he doesn't have to. The silence eats away at me, as what I have been told sinks deeper into my mind. I want to reject it, but truth is sound and can never be denied. I can't doubt the fact, I can only run from it. I look below me, conceding that I would rather die than face this bitter reality for another moment. "I'll never join you." My hatred rises. Vader makes one last offer, but I don't even hear. I release the post and plunge into the gaping wind tunnel beneath me.
A flash of thought fills my mind, some ill boding premonition that I can't quite identify. I don't feel anything as I fall. The light drains from my world, leaving me in darkness. What I know is consuming my soul, and I realize how I am eagerly awaiting the end. Death would be a refuge. Everything I believed is a lie, and there is no hope now. I've failed. All that is left for me now is the bitter truth, the truth of my destiny.

subset: commoncrawl


text:
It's good to seeTexas Tech win football games and equally good to see Coach Kliff Kingsbury's rules for his players about going to class and taking care of their schoolwork. Pre-season workouts have started, classes will start soon, and it's important the players do well in both. They are working for the degrees that will prepare them for their later careers.
See Also


text:
Holli smiled and waved goodbye, rumours had flitted around practically overnight that she and I had something going on. But in all honesty, she had come to me last year on advice about what she was going to wear to her cousins wedding, and since then, we've had a strong friendship. She sees me as her (nearly gay) friend(which according to her is the "ultimate accessory") , and I see her as something to kill time with.
I smiled at the table of sixth formers weakly as they oggled at me. I waved goodbye to Holli before joining the rest of my hokey team mates at our usual table by the biggest window on the most eastern side of the dining hall. Most of the hokey team members were older than me, but I have a sneaking suspicion that they only respected me because last year I convinced my dad to buy a crap-load of new equipment for us.
And I don't even like sports!
'Why are all those people staring at you, F.J?' Marnie, our goal-keeper, asked. Her brows were furrowed as she addressed me with my much-loathed nick-name. "F.J"... I sound like a tacky white rap star, and everyone knows that all white rap-stars(excluding eminiem) are terrible. But I live with it as it seems everyone, including my own twin, has taken to calling me this.
'Maybe because I'm so damn sexy?' I replied in a bored voice, picking up Marnie's sandwhich and eating it.
'Maybe you should stop being so cocky!' Joesef, another member, said quickly back.
'You know you want me.' I grinned devilishly, licking my lips at him, which caused him to recoil in horror.
'I got to go, the bell just went for the second time.' Joesef said, quickly changing the conversation.
'Your right, See you later.' I jumped up off my seat, waving my friends goodbye as I skipped merrily towards my classroom. I was thrown a few comments related to my gender preference, but I send air-kisses back in return.
It felt good to be back at school.


text:
Canvas Print
UNITED COLORSby Hi ! Kub
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Fine art print on bright white, fine poly-cotton blend, matte canvas using latest generation Epson archival inks. Individually trimmed and hand stretched museum wrap over 1-1/2" deep wood stretcher bars. Includes wall hanging hardware.
In real this images are 24 x 18 cm. They are at the present exposed in the BDX LAX exposition with Dave Kinsey in Bordeaux until 15th july 2012.
A work with watercolors, and ballpoint pen, who changes with your moods. Some days well, some days bad...


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Lock Haven Express Newspaper Archives
August 30, 1890
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Issue Date:
Saturday, August 30, 1890
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Friday, August 29, 1890
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Monday, September 1, 1890
Lock Haven Express
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Lock Haven Express
Lock Haven, Pennsylvania
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1889 - 2012
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OCR Text
Lock Haven Express (Newspaper) - August 30, 1890, Lock Haven, Pennsylvania 0* J ili? I �>" -.15' Vii !J "S �^'.rU.'^"'^^ ,'gj f-f^V%^' 4% npV |V "--A".*.'. is..^-. ' . ;;.l��" '- %\&~r> /% ^ ^ ^ *r I:. fc.-'i a 1' Effort � [. .i.m hasn't pro' idou ;v ;>;I-' furnished a pretty spectacle. -c-.v :ir the man "ho ha'h n.. I N�: ea*-. in :ro'i?o c it Yoik � thae. in a,' �illation in tho city 'mm WHO to l^'i is v England. Ihv P'in, consider the- grf-si>hopperi h3 wouldu't bo able to get on in the world if he did not jump at every chance. Canada flunks sho wants un agiieul-t-ira* cn-nbine. What sho real!}' wants D fi.nnr>:a,,ou. And sho will pot it. "W-;.vr sUa.ll it proG: the farmer tV lit can buy a woolen ahirt for a few occUi le."-.-: anr: Irro his mUre dock of sheep ,T ft-ks -.bo rbnrtdtf'iitV.a Inquirer. Ti:?::1,:: ito d>]-ii:;n^ ihc pr of Aiiri^as. According t'j tbu WtcUit� T.:vs\, (ho natives can got into fho circuf for otic liusbol of com, while last ypar it cot five. Tirr.it" are said to bo po many yachte for Xot York that their total cost w-->ui-*rPct ha--e a passion for yachting, ar: ! [!.';':r ipn av.i' doTii*1 in life arf1 rn:iny. iv :;�:':':*'> bp ti'ia'.'^ lit'ci'liji! thn*. do-ba'i- -".i t!;c 'I'ariS b:i: v. ill ^t.'V'i^rabir and a f1 V ta' Sen:;'.'1 in'mudir; '-bcriviCt^r STTTRPY ?1XA FOR RrCTVROlUT'i. r-of I'r'^^rl Inn ijul lciHt >ud tba" will insist upjii bis former potiit .on-that the mow discharge-! ! lit !\ l"' V'.' rof=.islue to cor/.'!]!]!1 work. All the Lat VI NUS'.Nr POT I'OL'KKI. 1 GENERAL AP FOREIGN NEWS up ami Viows of ti: 3-00 P. a. (Jit.' .M iHcrllunooua !llix!nri: of Sen?t> Mini N.tn-.nun^o .S'~ tiik value of somu deposits for fertili/.ing, it is m^-M iha'- last year Paris fertilized 1,-00 acres with its sew an-! niade them the most valuable agricultural laud in Europe. Berlin treated 1,000 ?,ores in the same way wiih a like rcsii^. The sewage nf the city of �o:i .'rings > -> -,o 00". uiocka hi a new business in Now York. Over 1,^00 c'ocks >:>t this kin-', have been placed already iu that city a; a rental of To cents a month. In some oases where -ha time of operatives in a taetory demantlp careful adjustment, an employe of the company visits the place daily and rejr'ilates the clock so far as may bo necessary. Ordinarily the clocks are wound once iu six days, and the. company attonda to that. A S.\>' Fp.ancisco paper assorts, that the fat-bion, or practice, of vrenring �^andon shoes is f>n -be increase in this country and in England. It is averred that by the aid of machinery a really neat and comfortable shoe can bo made so stylish that r.u youutr woman need be ashamed to vicar it for the street. The traditional wooden t.hoe which we have all read ab^n*. was i clumsy, baud made implement of inconvenience and noiao. "ut now, when a dainty maid trips along 'he Greets of a pretty mountain wwn, with h?r little *-;.titers clicking on 'be pavement, it make^ ma:iy i foolish young ri^art beat warmly. am; tor;, �>f ' ritury r of nr.- fields, thorn, 1 to have ne^n expectr'' w .i-the tiin*i�ands of emigrants , st*.'.irmed \w--i the new terri- : mma werr* given [n the world a-; i. his actiiiiiiy cornn to pass, �!v ti.'.i1'; �d th'i ji- ''plL' in that ter-ire in iM'ed nf th": ac'ual reocssities , whi'e twu-thi:ds of -ho f'innera j -.viR-at with which to piaut their These people, went *hcu>, most of iVitli Isttlo else than a few yoke of osou or a pair of hor^r-s, and the wa^un in �which t:i?y rods. Tliey nnw tiud therasolves in actual need. Nothing else could be lonketl for. Xo doubt all of these people could have done much bel!er by rymaininc whi'ro they name from. E''1 tir.STi.v the Ctsr^on County Uemo-crat'c Couvi'iiT.inn did not Huit Editor John I . S!iatTer, of tlie Ilenovo Record, and ho embraces occasion to express liis Roui i-meuts in Ill-linage more forceful than or-d;tt-.: in Thiiisdav's issue of that paper. Here is what he says. un T ntj'- nil. ct|.. ')ttc:H.-frt umo-l uvTV �1 -.in' of ! 1 hin t'.lP county -n i-rili-ry, c->rnjj'Hcin (-�ilt.-r.-. iumI 'Jrunk(-i; i un pr-nMiiiitnt It >!.t wcitlt ui !):. national questions he said. I wish to declare the opinion thai the UniLui! St'-ite � liaB reached a poiLt where jno of its high est dut'es is to enlarge tho arena of forcgi trade. Under the beneficent policy of pro 1 'Cction we have developed a votunm o ! maaufaotures wlpob, in many department; t overruns 'he demands of the home market per;t; ) -n tjlC o{ agriculture, with the on roeuao propulsion given it by our agricu! tural implcmentfl, we can do far more than produce breads tuffs and provision? for our own people. Nor would it bo an ambitious destiny lor so great a country as ours to manufacture only what we. can consume or 'o produce ov.ly what we cud sat. "Happily the great majority of �..ui" pro pic, without Stric� regard to party lines, bclic-e "hat the results th** AmjrVan ;r-n. pi* fv'">m the ]t ' ,'ctiv^ p:'>".\y h.irf L--"n '.ccalculably l.'er.eiicntit, aggreg'-i^ng a f :he American people." After citing figures to show that the ; balance of trade with countries south of us � was against us, exceeding our gains from all the rest of the world, Mr. Biaiue said. "Tho inevitable tendency is, I think, w ward an increase of the free list. ' 'ur great mistake was made when we 1-^gan to repeal war duties on so large an amount of imports. Instead of thia course-which I must say was one of carek^suess and wastefulness by both politic.-.I psiv'ues'- every repeal of duty should havi; he>;u preceded by a most thorough investigation, and whenever it was found practicable to export anything from the United States and thus establish reciprocity of trade, it should have been done, but with all *he duties we have thus far repealed it has been a question of whether we should ge* something or get nothing. \Yo have olirr sen with our eyes closed to get nothing. I hope now with our eyen open tltV. we shall in future choose to get, something. i\*e encounter opposition tr* this policy from those, who declare that if we enter !M-.' r�eij)i--ci'y of tr id-- \m-��!.:in'; and th^iK indirectly bring abou* comjiltte free trade. I don't -ire the. h^'ic of this ;\>m\ 1 vn*i -^re the face Wili not pruv� what is p-vdi reeiprne';y with -..... !:atio>,i h'jc'.inse wt Tin 1 advitnt.w;;- m it. *�Ve may ileclinc to en"er into rec.pv-jc'y with another nation because w� s-.-e no ad vantage iu it. "Reciprocity Kintply & i>*/r,':y :>n may make Or lose torus. Our peoplo �lo not roaIi**e the great fact * hat if specie payment is endangered in this country it is likely to be endangered by our present sysH-m of trade with the Latin American state.*. The few millions of gold ' hat have gone out of this country within tho list tbreo months havo created uneasiness iii certain quarters as to our financial posi tion. !t is very extraordinary that tho loss of these millions from tho b.uiks in all should ho accounted ho serious an event when we have lost a much larger amount during the samt' period from the eondi-tion of our trade with the r-uiiiitncs south tt -is without i .xci-Uip thi' h'!i;.t '.o*t>iva tiou. "When oui inemhiiiit.'' ii.o h.inl'crN corny'm thon.v.igh'.y atpre"!,!*" -J.'h ta-;' u'e shall rocwive itid and inliut ui the reform of our trade from a quarter which tins far It. has been impossible to >�';;k�:;.i:;. , W. Aug At - o'clock this evening a colored man named �Toe Solomor, employed in the Wheeling terminal railway company"*) tunnol, now In course of construction, stepped on tbt wire which supplied the current to tuston 1^, l'ittsburg 0. *' York-New York 11, Chicago r>. fdklyn -Brooklyn 10, Cleveland V*. ladi'lp!iia--I'h:,;ideii>hia i;, Buffalo frh.. Piilifnlciphlf i n'.eiik'o ntn.)>u 11'!eveiRiel... tituir.uo..... oiiisvtlle... :.. I..mis. AMEI'.ICAN , Woo. Lost. Kaitmi(j[i- Tlie lltiifihftrt ^f>:-tfi -u rhf t;r�:iti Tbt' Sisters wore welcomed by a magnih-ceut house and in turn gave a maguitlceut on tort ain merit. The Misses Leo, Bertie, (Vo'.die and Stella Rinehart were received with marked favor, while tho comedians won a complete victory the first round. I.*."* Kiuehart is "i'.-.-iiut.inl af .-wct't' A ;:-.J n-' a- tn'aiit ihig furd^of! as t;a> ~ uotten nr n a. readable fori. Jljillnttttii; for ToachurH llcnth of :iu Arim' Lauy-Uoion Veteran Lc(;i�>n-'I'!iey Tl'un' � rri!** Iii hIc'j-'I'Ih! White 1 �i>crco-i he Lulu* a D�f e�* oil -Tiio Welcoino Ti'tie Hrnwli-e Nci'r. 'f ho contest fur the handsome chair which Sloan propuses t j give to the most popular gentleman teacher in Clinton county, increases iu interest as the time draws near for tho polls to closo. V p-wanis of ten thousand ballots have been oast up to 8 p. m. last night and of that nu;nbur Mr. J. l\ Anthony received "j"?'!. There is likely to bo somo surprif-ivi, however, ffh-ui the foial count is made. Tho. following is the roth tor each teacher up to last night: ' 1*. Anthony......................'JOSS ............2500 .............r:ss ..............iti-fr, ...........KC7 ........... r-i Kay, Kl?:lr-i ringing w;^ Th>' '..�-.mpa:iy is ;' tii'io's aini v/c ] itig it tt> mir sister on the :oad.--UUi i'rh. �1 out with new eos-isnre in recommend oh as one of the best Jmrnnl, Nov, Tin' U.rrf'liiweijirt HHiliMf. Down at Williamsport, according to the >
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Many will enter, one will win. If you have not reached the age of majority in your state of residence (18, except AL and NE, 19 and MS, 21), you must
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Albin quiet on Magpies
Juan Albin insists he will not decide on his future until the summer, amid speculation he will join Newcastle.
By Francisco Acedo
Last Updated: 31/03/10 6:02pm
Juan Albin insists he will not decide on his future until the end of the season, amid speculation he has agreed a deal with Newcastle.
The 23-year-old Uruguayan forward has been with Getafe since 2006, after moving from Nacional.
Newcastle are understood to have been keeping tabs on Albin for a number of months, as they look to plan for life back in the Premier League.
Now Spanish sources claim that Newcastle have offered Albin a three-year deal to move to St James' Park on a Bosman transfer in the summer.
Getafe have offered Albin fresh terms in a bid to stop him leaving for free, but it now seems he is set to leave the Madrid-based outfit.
Speaking about Newcastle's potential interest, Albin insisted he was focused on trying to win a place in Uruguay's World Cup squad.
"This year is very important to me," he said.
"I attend to announce what my future is at the end of the season.
"Like any professional, I don't reject any offer - and Newcastle are an historical club that will return to the Premier League.
"But I will keep calm and study them."


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Moody's lowered its rating on Italy's bonds by three notches on today, saying it saw a "material increase" in funding risks for eurozone countries with high levels of debt and warning that further downgrades were possible.
The agency downgraded Italy to A2 from Aa2, a lower rating than it holds on Estonia and on a par with Malta and kept a negative outlook on the rating.
The euro pared gains against the dollar and Japanese yen immediately following the announcement which comes after Moody's rival Standard and Poor's cut its rating on Italy by one notch to A/A-1 on Sept. 19.
The cuts underline growing investor concern about the eurozone's third largest economy, which is now firmly at the centre of the debt crisis and dependent on help from the European Central Bank to keep its borrowing costs under control.
"The negative outlook reflects ongoing economic and financial risks in Italy and in the euro area," Moody's said in a statement.
"The uncertain market environment and the risk of further deterioration in investor sentiment could constrain the country's access to the public debt markets," it said.
It added that Italy's rating could "transition to substantially lower rating levels" if there were long term uncertainty over the availability of external sources of liquidity support.
Italy's mix of chronically low growth, a public debt mountain amounting to 120 percent of gross domestic product and a struggling government coalition has caused mounting alarm in financial markets.
Moody's decision came as little surprise after the agency said on Sept. 17 that it would finish a review for possible downgrade of its rating on Italy within a month.
But it highlights the growing vulnerability of the eurozone, which is already struggling to contain the crisis in the far smaller Greek economy and which would be overwhelmed by a crisis of a similar scale in Italy.
"It's not that unexpected but it doesn't help the situation at all," said Robbert Van Batenburg, Head of Equity Research at Louis Capital in New York.
"They have already traded as if there was somewhat of a downgrade in the works, so it will probably force Italian policymakers to embark on more austerity programs. It will put another fiscal strait-jacket on them."
Moody's said the likelihood of a default by Italy was "remote" but it said the overall shift in sentiment on the euro area funding market implied a greater vulnerability to a loss of market access at affordable rates.
Italy's relatively modest budget deficit, conservative financial system and high level of private savings had kept it on the sidelines of the eurozone crisis while countries like Greece and Ireland were sucked down.
"Italy is being punished not because its finances suddenly deteriorated, but because investors have become more sensitive to its long-standing weaknesses," said Nicholas Spiro, managing director of Spiro Sovereign Strategy in London.
He said markets appeared to be focusing on the weakened centre-right government's lack of progress in stimulating the stagnant economy, which many analysts expect to stall or even slip into recession next year.
ReutersReuse content


text: Heyyo and welcome to my page <3 I'm Ino and moi is currently 14 years of age c: Inouri is not a real japanese word. Yea, just thought y'all should know hahhaa xD I don't have any particular likes, dislikes or ambitions, other than I <3 Fairy Tail, Naruto, Bleach, Kuro@$*!suji, Hunter x hunter, Kaichou Wa Maid Sama, Accel World, Sword Art Online, Guilty Crown and Hetalia. If you know and <3 them, you are awesome and ily x


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Jademist Dancer
105,020pages onAdd New Page
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this wiki
- Jademist Dancer
- Item Level 1
- Binds when picked up
- Use: Teaches you how to summon and dismiss this companion.
Jademist Dancer summons an Elemental Battle pet Companion of the same name. It is a 0.47% drop from Jademist Dancers in the Timeless Isle.


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text:
5 RV Parks near Riverton, Wyoming
Arapahoe, Wyoming 8.39 miles SW
Shoshoni, Wyoming 14.66 miles NE
Ethete, Wyoming 18.12 miles SW
Fort Washakie, Wyoming 23.82 miles SW
11124 WY-789 Riverton, Wyoming 82501 (map) | (307) 856-2869
Sites: 45 | Latest Rate: $40.00 | 6 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2012 - $40.00
Kind of a sad little place and very over-priced. As others said, somewhat run down and needs a lot of work, though bathrooms have been renovated. Right next to the highway, so noisy up front. Lots of tents and residents in older rigs. Watch out for high voltage and poor water quality (as tested). Verizon cell and MiFi worked fine; no mention of Wi-Fi by office. Most sites in shade, not level. Sat TV instead of cable, not many channels. - Annie's Song
Jun 2012 - $36.00
Very friendly owner, well informed about local information and accommodating in order to get a larger rig in place (allows you to drive on grass or park vehicle in another site if you don't fit in the pull through available). The only reason we gave an 8 for rating is the site was not big rig friendly. This is not a resort so don't expect a lot. The owner is trying but the CG needs a lot of TLC. WiFi worked great. - SubSailor
May 2012 - $38.00
Expensive but it's the only thing in the area unless you boondock at the Walmart right down the road. OK for a one night pull off the road. We were early in the year and it just needs freshening up. Nothing impressive but adequate. Owner very nice. - westie0506
1618 E Park Ave Riverton, Wyoming 82501 (map) | (307) 857-3000
Sites: 60 | Latest Rate: $39.00 | 28 Reviews
|Clean Restrooms:
|Clean Showers:
Sep 2016 - $39.00
This park is good for an overnight stop. Very quiet. It's located off the main road, there aren't any signs leading you there so it might be hard to find without GPS. There is a sign near the office asking that you not park on the grass. No problem, since there isn't any. The very friendly owner checked us in gave us a site close to the office to ensure wifi for us. As other reviewers have stated there is some deferred maintenance. We'd stay here again if in the area. - Recycled
Jul 2016 - $36.00
We were very happy to get a pull through full-hookup site on short notice when we left Dubois (about 1.25 hours west) due to a fire pre-evacuation notice. Call for full directions when getting close, it's a little off the main drag. The accommodating owner/manager stayed late for our arrival and gave us a full orientation. There were many welcome shade trees (it was hot!) and very close to our site, but not a problem for our motorhome with no slide-outs. We would not have been able to put out our canopy, though. The gravel/dirt site was level and required no blocks. The electric power was strong and consistent and the modern electric tower was nicely high enough to allow the surge guard use. The water was of good pressure, clean, and decent tasting. Sewer hookups were easily accessible. WiFi signal seemed strong, but the amount of traffic seemed to overwhelm the system in the evening. Verizon cell service was good. There were two nice grassy areas for dogs, which were clean due to the many reminder signs to pick up after your dog. The park has made an effort also in this desert area to brighten the landscape with pretty watered flowers at each pull-through site and other areas near the entrance. The bathrooms were very clean, spacious, well-lit. Showers also very clean, $1 for 10 minutes with water-flow reducing shower heads. The laundry was wonderful, 13 regular washing machines, 2 oversize commercial washing machines, 8 big dryers, lots of folding space, modern vending drink machine, all in a spacious, swamp-cooled room. Lots of other nice RVs here, and the park seemed safe and quiet. A mosquito spraying truck rolled through in the evening. The RV sites are next to the same-owner storage facility. Not a fancy park, but totally more than adequate as a stopover. The owners have obviously made a lot of effort, focusing on important functional and hygienic improvements. Remember this is a desert area when wishing for lush landscaping. - corglet
Jul 2016 - $36.00
Must have recently changed hands. Sites are dirt and not clean. Lots of weeds and many dead trees. Garbage dumpster was over flowing and looks very bad. Wi-Fi not good at last few sites and no cable or major networks available with regular antenna. Very dusty from people driving through park including park personnel on golf carts. They also drive very fast...
Manager was very friendly but over whelmed.
Not as represented in camp book. - D'art campizard
1104 N 2nd St Lander, Wyoming 82520 (map) | (307) 332-3142
Sites: 30 | Latest Rate: $12.00 | 2 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2012 - $12.00
This park caters mostly to full-time residents, with a a dozen sites or so for folks staying in the area for a few days. The rate we paid was for a month's stay; daily rates are higher, as you might expect. Electricity is extra, and we will also get an electric bill some time in the future. The sites are level and there is adequate space between the rigs, and the sites are shaded by trees. We had to adjust our position a bit in order to get satellite TV. The management was friendly, and was helpful in being sure we got our mail and packages from Fed-X. Washing of cars and rigs is allowed. We enjoyed our stay, and would stay here again. - hoppytoad
Jun 2006 - $20.00
Poorly maintained park. The laundry room had 3 washers, 2 not working, 2 dryers, both not working, and a clothes lines outside for drying. The restrooms and showers were just nasty. It's located in town with no fencing around the park. An overnighter enroute maybe? - zookep9
715 E Main St Lander, Wyoming 82520 (map) | (307) 332-5159
Sites: 65 | Latest Rate: $39.00 | 51 Reviews
|Clean Restrooms:
|Clean Showers:
Oct 2016 - $39.00
Great hosts, clean washrooms, small clean laundry, reliable wifi, few tv channels on antenna. Prefer back in sites looking back onto town but they were full when we arrived. Pull through still okay. First time we've seen recycling bins in a while. Easy walk down the hill to nice town. We stop here every year. - Darleen
Sep 2016 - $31.00
Stayed for 2 nights in a pull through with enough room for toad. Staff came out to site to make sure SAT TV was ok and it was. Nice level site of gravel with grass, table and fire ring. Very friendly neighbors. Used showers and they are private and we're very clean. Wife liked that we could shower together. Camped at Sleeping Bear in a motorhome. - mdmnkcm
Sep 2016 - $36.00
This is an OK park and we had a good site. The wifi was pretty good on my phone, couldn't connect with my computer. Utility placement is inconvenient--sewer so far forward we had to wait till pulling out to use it. Water and electric at front--they offer use of extension electric cords and water hose to those who need it. Grass needs watering. - John and Carol
176 Sunflower St Lander, Wyoming 82520 (map) | (307) 332-0155
Sites: 22 | Latest Rate: $1.00 | 33 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2015 - $1.00
The park has closed.
I called to make reservations and the message said they had retired and the park is closed. - sfrantz
Aug 2014 - $30.00
This is a very nice small park, well taken care of. Large level gravel pads with manicured grass at each site. Lander is a small town with lots to see and do. Highly recommended. Better make reservations well in advance, if possible. - User3654
Jun 2014 - $30.00
Nice little park. Very clean and well kept. Each site has a picnic table. Lovely area overlooking a golf course. - phyllen


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Miss-JVModel Female London, England, United Kingdom
My Website: http://bookjadevalentine.wix.com/jadevalentineMy MM URL: http://www.modelmayhem.com/Missjv
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About MeJade Valentine, from London, UK, a part time, semi professional model, as well as an aspiring recording artist.
The aim is to get sponsored by a US agency... I'm very hard working, professional, reliable and friendly. I like my shoots to be fun as I think this comes across in the photo and just makes life easier for all parties involved! I usually bring a chaperone to my first shoots with a photographer for obvious safety reasons.
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5-HT(2) receptors are coupled to phospholipase C (show PLC Proteins) in bovine ciliary epithelium.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2 (show CA2 Proteins)+) flux that enhance mitochondrial metabolism.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT (show DDC Proteins) activation of 5-HT2B receptors in postnatal microglial cells
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter (show SLC6A4 Proteins) has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR (show PPARA Proteins)-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT (show DDC Proteins)(2A)/5HT (show DDC Proteins)(2B) receptors.
5-HT(2B) R [deficiency] interferes with the mechanisms directing amelogenesis
Activation of 5-HT(2B) receptors on bone marrow lineage progenitors is critical for the development of pulmonary arterial hypertension.
The 5-HT2B receptor may contribute to the regulation of human glucagon (show GCG Proteins) and glucose homeostasis and the interplay between glucagon (show GCG Proteins) and insulin (show INS Proteins) secretion.
Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke.
the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis
Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity.
Data indicate that hydrogen bonding interactions with Ser3.36 and Thr3.37 were important for isoflurane binding with the 5HT2B receptor.
results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity.
Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors.
a new and unanticipated role of the 5-HT2B receptor N terminus as a negative modulator, affecting both constitutive and agonist-stimulated activity.
5-HT2AR, 5-HT2BR, and 5-HT2CR (show HTR2C Proteins) expression in HEK293A cells significantly increases susceptibility to JCPyV infection
distribution of serotonin 2B receptor is species different in the pig small intestine and the intensity of serotonin 2B receptor becomes stronger as the small intestine matures
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
5-hydroxytryptamine (serotonin) receptor 2B
, 5-hydroxytryptamin receptor
, 5-hydroxytryptamine receptor 2B
, 5HT2B receptor
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 2B-like
, NP75 protein
, 5-HT2B serotonin receptor
, 5-HT 2B receptor
, 5-hydroxytryptamine 2B receptor
, 5-hydroxytryptamine receptor 2B variant b
, stomach fundus serotonin receptor
, serotonin 2B receptor


text:
Baby Lutino cockatiel. Hatch date February 16, 2017. Sex unknown. Fairly social, will step up and sit on shoulder. Raised on seed and pellets. Cash…$85
Playful loving parrots for $175 each or $300 for both. The one on the left is around 1 year old, while the other one is around 2 years old. Would love…$175
For sale is a young Pineapple Green Cheek Conure. We purchased 'Rainbow' in September 2016, for our daughter's 10th birthday, for $300 from a local breeder…$200
Selling my beautiful sun conure semi tamed she dont like nen$360
Handfed Baby Greencheek Conures. Rare Color- Dilute Hi Red Yellowside. Pure greencheek, with tons of color. You get the wonderful personality of greencheek…$450
Handfed Baby Crimson Belly Conure. DNA Male born 2/1/17. Close banded, DNA certificate, and big baby. Eating veggies/rice/beans/fruits/birdie bread. Small…$475
Normally we sell our handfed babies for $125 but if you're interested in this one we will let this baby go for $100 This baby is absolutely gorgeous-…$125
Very pretty We believe this baby is a she, this pretty bird is about 6 months old. Prefers not to be handled, but is still young you can continue to…$75
I have a 3 month old female Camelot macaw for sale in Dallas Texas. She is still being hand fed and is very sweet. She's a DNA tested female and comes…$2,200
I have been breeding and selling birds for 15 years. My birds are well fees, not just with seed. I am selling red, white mosiac canaries and they are 100…$65


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The property is located 20 km from Riga, 200 m from the highway A7 and the river \Kekaviņ\. The property has a separate 2 storey farm building-140 m 2, and the separately-residential 2 story log sauna-100 m². The area is landscaped, is both a paved paths, both created and cultivated plantings, fruit trees and bushes.
Townhome – Riga, Latvia
247,000 €
Total area: 290 m²
- Land area: 1,400 m²
- 2-floor building
- Total rooms: 6


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I just couldn't find the time to ask Grim, Him and my mother were always together. They were always ataring at each other's faces, sometimes they started snogging. They totally forgot that I was there! I mean come on I was the one who got them back together and they were ignoring me! Maybe I was invisable, one of those ghosts who were never seen, only heard or seen by throwing things about. I didn't ask to be a ghost! If I had known this was going to happen I wouldn't have brought them together!
Why was I being ignored?! I hadn't done any thing to deserve this! I was the one who brought them together! I should be rewarded!
As they leave the room, to the bedroom- I don't need sleep anymore- I decide that it's time for me to leave. At lest long enough for them to relise I'm gone- I bet that will take ar least a month. Better pack my bag then.


text: A wonderful improvement from my previous visit this summer when I had the world's worst steak sandwich here. The restaurant is recently under new ownership and it's a change for the better. We stopped in for dinner on a wet Friday night and sat at a high top table in the bar. I ordered the pork loin dinner special- fantastic.... More


text:
French prosecutors suspected him and another of Leila Trabelsi's nephews of having ordered the 2006 theft of a yacht belonging to a French investment banker that turned up in the Tunisian port of Sidi Bou Said. Still, a French judge ruled that the two Trabelsis could be tried at home, despite the fact that Tunisia was ruled by their uncle. It was not clear if any trial was ever held in Tunisia.
In Images: Tunisians walk in the looted house of Adel Trabelsi, a nephew of the former President's wife, Laila Ben Ali, in Gammarth, 25 kms north of Tunis, on Sunday, January 16, 2011.


text:
Restoring euglycaemia for weeks or months improves insulin secretion in patients with type 2 diabetes (T2D). We tested whether mild decrements in fasting glucose (FPG) acutely affect β-cell function and insulin sensitivity. Thirteen normotolerant (NGT) and 10 T2D patients volunteered in pairs. In an isoglycemic test (Iso), after 100 min of stabilization, an incremental glucose infusion over 3 h was applied to raise plasma glucose to >22 mmol/l, followed by an arginine challenge; in a subisoglycemic test (Sub), a glucose infusion matching the plasma glucose time course of Iso was preceded by an insulin infusion period (100 min) aimed at maintaining a mild FPG reduction while avoiding hypoglycaemia. β-Cell function was assessed by mathematical modeling, whereas the acute insulin response (AIR) to arginine was determined from C-peptide levels. In the Sub, FPG was lowered by 17% in NGT and 31% in T2D patients. On the glucose ramp, total insulin release was lower in Sub than in Iso in both groups [from 106 (43) to 75 (39) nmol/m−2 in NGT and from 71 (63) to 64 (41) nmol/m−2 in T2D, P = 0.001]. In the Sub, β-cell glucose sensitivity was significantly (P = 0.008) reduced in NGT [from 50 (31) to 43 (21) pmol·min−1·m−2·mM−1] but not in T2D [19 (20) to 20 (20) pmol·min−1·m−2·mM−1]. Likewise, AIR was lowered in NGT [8.9 (4.6) to 7.1 (4.4) nmol/l, P = 0.048] but not in T2D [4.7 (3.3) to 5.3 (3.2) nmol/l]. Insulin sensitivity improved in NGT but only marginally in T2D. Prestimulatory glucose levels acutely influence both β-cell function and insulin sensitivity differentially in nondiabetic and type 2 diabetic individuals.
- arginine-stimulated acute insulin response
- β-cell function
- β-cell mass
- fasting plasma glucose
- insulin sensitivity
- Copyright © 2016 the American Physiological Society
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text: There are four bedrooms, one bathroom and three shower rooms within this house. At ground level, you will find a bedroom with zip-and-link bed with an en-suite shower room in the former barn section with another double bedroom in the farmhouse section, which has a shower room available nearby. Upstairs there is a double room with king size double bed and a family room with two sets of bunk beds, which have access to a bathroom and a shower room respectively.


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Hi, I was wondering if anybody new if these will fit on a 2001 impreza?
Aluminium MT Foot Rest STI Pedals FOR Subaru Legacy Outback Forester Impreza | eBay
it says they are meant for 2008-2012 but i'm thinking they should still fit or be modified to fit.
Any help will be greatly appreciated thanks


text:
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Sorts of Kitchen cupboards Explained
Февраль 2016
Living rooms cabinet which was basically created to store washing machines has continued to develop tremendously during the last a long time. Today's kitchen cupboards are worlds aside from the cabinets 20-30 years back. On this page we will speak about a variety of cabinets that happen to be available today available in the market.
A kitchen cabinet falls into three different groups which are determined by their shape and specifications.
Base cabinets:
These are generally one common style of cabinets you can buy. The bottom cabinet rests on to the ground in most cases possess a counter. These are the basic most preferred furniture for flats and apartments which normally have very moderate kitchen space.
The height of the cabinet is just about 34 inches to 36 inches. The depth may vary from 24 inches to 30 inches. It usually features a single door and several newer models can have a double door as well as the inside the cabinet may either have shelves or multiple stacked drawers. This can be a most preferred kitchen cabinet mainly because of its simpler design.
Many altered versions of base cabinets are also available in the industry. The most famous ones are definitely the sink base and also the corner base. The sink bases are the normally purchased kitchen cupboards in the world. It usually incorporates a false drawer as well as an open area the place that the plumbing tasks are hidden. A large part base in contrast is really a every other shelf mainly familiar with store some day-to-day stuff that are popular about the kitchen.
Wall cabinets:
These cabinets are designed in a manner that it could either be integrated inside the wall or simply just hung on the wall. These are essentially shaped like basics cabinet, really the only difference is the fact that these are typically mainly used like an overhead cabinet for storing things in your kitchen. These cabinets are unique and therefore are widely used in apartments or individual houses. The commonest thing that you should consider if they are buying this kind of cabinet will be the height on the kitchen ceiling and the person's height. You do not need to investing in a tall cabinet but not the ability to attain the top shelf. So ensure you buy a cabinet to enable you to utilise all the shelves and drawers in the cabinet easily.
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text:
Systems Biology Opens New Research Pathways
Systems Biologists Are Attacking the Encrypted Messages That Would Allow Us to Predict and Change the Course of Disease
Individual Tumor Profiling
Has Tumor Molecular Profiling Enabled More Effective and Less Toxic Cancer Treatment?
Top 10 Under 40
Up-and-Coming Stars Shine in Biopharma Research and Business
Podcast: FDA's New Commissioner Hits the Ground Running
Scott Gottlieb, M.D., Commits to Speeding Up Drug Reviews, and Maintaining Safety and Efficacy
Prometheus to Perform Molecular Profiling of Cancer Patients for Bayer Schering Pharma
Bayer Schering Pharma is tapping Prometheus Laboratories for mutational analyses services. Under terms of the services agreement Bayer will provide clinical samples from its studies to Prometheus, which will carry out mutational analyses to determine the presence or absence of existing and novel cancer-related mutations. The aim is to improve patient stratification in clinical studies and speed the development of Bayer's oncology diagnostics and therapeutics pipelines.
The agreement builds on the firms' research collaboration and license agreement, signed in March, through which Bayer had access to Prometheus' CEER oncology diagnostic platform, for use in helping to stratify patients to appropriate drug candidates. The new agreement effectively adds Prometheus' mutational analysis capabilities to the mix.
"This agreement represents further validation of the importance of our oncology focused CEER and mutational analysis platforms," states Joseph M. Limber, president and CEO at Prometheus. "The combination of our mutational analysis and CEER platforms that this agreement represents is an important step to providing a more comprehensive analysis to Bayer that may result in improved selection of patients who will benefit the most from specific drug candidates Bayer is developing."
Prometheus specializes in the development and commercialization of personalized pharmaceutical and diagnostic products. The firm's primary focus is on the detection, diagnosis, and treatment of disorders within the fields of gastroenterology and oncology. Its CEER platform is designed to measure the expression and activation of specific cancer pathways in tissue or blood samples, for use in the selection and evaluation of developmental drugs and for the real-time molecular profiling to monitor the effectiveness of targeted drug therapies.
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Apple, Alphabet, NXP Among Morgan Stanley's 'Autonomous Drive 30′
Morgan Stanley analysts Adam Jonas, who covers automotive, and his tech colleagues, including James Faucette, Katy Huberty, and Brian Nowak, today offer up their thoughts on the future of autonomous vehicles and the sharing economy, describing in rosy terms the development of the technology as if it were "a drug that could save 1.3 million lives and prevent serious or incapacitating injury to tens of millions of people annually."
The authors highlight 30 companies they think stand to benefit, including Alphabet (GOOGL), Apple (AAPL), Cisco Systems (CSCO), Microsoft (MSFT), Mobileye (MBLY), Nvidia (NVDA) and NXP Semiconductors (NXPI), which they call "The Shared Autonomous 30."
The technology corner of the note is summed up succinctly as follows:
600bn hours is a lot of time spent inside a car that you're not driving... it ́s not surprising that so many firms are directing significant strategic efforts and investment toward delivering and monetizing the content and data opportunities. Apple (AAPL) and IBM (IBM) were included for their skills in the relevant hardware/ecosystem. Microsoft (MSFT) has long made auto a strategic priority, while our Software team sees Red Hat (RHT) as best-positioned in open source software development. Our Internet team selected Amazon (AMZN), Alphabet (GOOGL), and Facebook (FB) for their dominance in capturing commercial value and time spent by consumers enclosed in a mobile, connected, supercomputing environment. Our Media team nominated 21st Century Fox (FOXA) and Disney (DIS) as beneficiaries of the incremental content consumption opportunity up for grabs.
The traditional auto market will "struggle to attract and retain the best talent," the authors opine. "However, we see several that possess unique attributes for long-term growth including Mobileye (MBLY), Magna (MGA), Delphi (DLPH), and Tesla Motors (TSLA).
Their overarching view is a slow rollout in 2018 and 2019 of autonomous vehicles via fleets:
The first applications should take the form of small fleets, traveling slower than 25mph, fully autonomous, fully electric, and geographically limited to as little as 1 square mile. We see the rollout of shared/autonomous/electric transport as not unlike the rollout of the early electric utility grid in the 1880s and 1890s when names like Edison and Westinghouse were engaged in a city-by- city transformation. Public policy and the right partnerships will be critical to the outcome for a city's economic growth, population development, and public health and safety. While many of the full benefits of a shared, electric, and autonomous ecosystem may take decades to fully play out, we believe industry developments and investor appreciation of the technological path can have a material impact on share prices of select companies even over a three-year horizon.
If you're interested in whose stock to play in the fleet market, consider the following:
Autonomous trucks offer substantial growth and cost-cutting opportunities to the fleet operators that can apply the optimal technologies to transform their existing networks. Our Freight Transport team have written extensively on this topic and have selected Swift (SWFT), Old Dominion (ODFL), and XPO Logistics (XPO) for the list.


text:
Royal Captain (East Indiaman)
From Wikipedia, the free encyclopedia
At least two vessels named Royal Captain sailed as East Indiamen for the British East India Company:
- Royal Captain, launched in 1760, which made four voyages to India, the East Indies, and China between 1761 and 1771.
- Royal Captain, launched in 1772 and wrecked in 1773 in the South China Sea.
|This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.


text: 3 Points Harness Safety Belt For Racing Car - Heshan Changyu Hardware Co.ltd Toggle navigation TRADE DEALS Products Companies Product Company Search LOGIN E-mail Password Remember me Join Free JOIN FREE HomeAgriculture Security & Protection 3 Points Harness Safety Belt For Racing Car PRICE: contract price Product Description 3 points harness safety belt for racing car Product descriptionModel Number 3A-2 Main Material Polyester 45#steal ABS Seat belt Color black/blue /red/green Webbing Material 100%Polyester Fixing Type: 4 points Webbing Size: 2 inch 3 Points Application For most car or other type vehicles M.O.Q.: 1000pcs Payment 30% T/T as deposit, 70% T/T before shipment Packing: Neutral packing or customer required Shipment: air or sea Nearest Port: Huang Pu Port of Guangzhou Our Advantages and selling points:1.Environmental materials. 2.Durable and reliable. 3.Different styles, colors and sizes are available. 4.Small trial orders are accepted. 5.The size and packing: as requested. 6.Price term: FOB shanghai is OK and this will be convenient for you to import from us.7.accept your design, offer OEM service. 8.Factory directly shipping with good quality and reasonable price. Packaging & ShippingModel Number 3A-2 Packaging Weight 14KG Net Weight 13KG Carton Size 52*25*20cm Package Requirement One pcs per box、10pcs one carton Shipment sea / air Loading Port Guangzhou or customers requirementFAQ Q1: Can I have free sample for testing?A: Yes, If we have in stock, but shipment should be paid by your side.Q2 : How can I pay?A: T/T, L/C, Western UnionQ3: Can I make my logo on the packing?A: Of course , If the big quantity , we can change the packing ,if small quantity we can make logo sticker put on the packing.Q4: Can I have a visit to your factory before make order?A: Sure, welcome to visit our factory. Here is our factory address: No22Area, Industrial Zone 3 ,Gulao Town He Shan city, Guangdong ,China We can pick you up in the airport. Other products Universal racing car seat Price: contract price Hot selling 3 inch 5 points camlock racing harness Price: contract price 3 inches 4 points racing harness safety seat belt Price: contract price 3 points harness safety belt for racing car Price: contract price Company Info Heshan Changyu Hardware Co.ltd Contact Person: Fengping Li Phone: 86-20-38052433 Contact now × Contact form Your name: Your E-mail: Your Phone: Subject: Enter a message: Close


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Need a Measles Titer in Fridley, MN? Simply order online 24/7 and get a fast, affordable Measles Titer at a lab near you (Find More Locations):
Why would I get a Measles Titer?
The Measles Titer is a blood test used to prove immunity to Measles. People in Fridley, MN get the Measles Titer for general screening or for work or school compliance.
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text:
Neighbors frustrated over Richlands sinkhole problem
RICHLANDS, ONSLOW COUNTY - An Onslow County community in Richlands is concerned over a sinkhole that's affecting their backyards. Neighbors in the Trifield Estates Community said sinkholes have appeared along a row of houses on their street and across the neighborhood.
Resident Cory Dunlap, said neighbors have reached out to several agencies and filed official complaints without a real outcome.
"We can continue to dump money to try to keep our kids safe and keep the fences from caving in, but it's just never going to stop. The underlying problem is the drainage ditch is not properly sealed," Dunlap said.
Dunlap said the underground water drainage pipes beneath the fences along Amberwine Circle are getting soil in them, which creates gaps in the ground that turn into sinkholes.
Neighbors tell NewsChannel 12 that the sinkholes have been an issue in their backyards for over a year.
Resident, Tonya Dunlap said all the grass and weeds growing over the sinkholes makes them hard to see, posing a potential threat for children and pets playing in the backyard.
"My son and a couple neighborhood boys, several times I've had to yell at them to get out of the sinkhole before we put the gravel in there because to them it's a fort. You don't know how far under it goes or when it's going to cave in," Tonya said.
The question for the residents is: Who is responsible?
Neighbors said the City of Richlands should fix the problem. However, Richlands County Manager Greg Whitehead said the developer put those pipes in, and the state signed off on the storm water permit.
Whitehead said the developer of the neighborhood or the state would likely be responsible. On Friday, he said the developer for the affected neighborhood plans to inspect the problem soon.
A private licensed engineering company hired by an insurance company inspected some of the sinkhole areas. Their analysis said one location showed no evidence of a geotextile fabric at the joint of the water pipes.
Geotextile fabric is used to seal pipes and prevent water or soil from getting in them, which is NCDOT standard protocol.
Until the pipes are sealed, the report shows storm water run-off flowing through the backyards will continue to go into storm pipes creating sinkholes.


text:
Uh oh. This is not good.
Online Sales for Girl Scout Cookies Are Approved
Girl Scouts are adding digital marketing to their formidable arsenal of charm, cuteness and perseverance to sell millions of boxes of Thin Mints, Samoas and other longtime cookie favorites.
After years of prohibiting Internet sales, the Girl Scouts of the U.S.A., the group's national organization, has approved "Digital Cookie," a platform for scouts to sell and ship the colorfully boxed cookies to friends and relatives around the country.
The expansion beyond traditional selling strategies like operating booths outside supermarkets, sending order forms into their parents' workplaces and door-to-door canvassing is expected to increase the nearly $800 million raised in annual cookie sales. More than 80 percent of the two million girl scouts sell cookies every year, for about $4 a box, the national organization said.
(read more)
Friday, December 5, 2014
News: You Can Now Buy Girl Scout Cookies Online
5 comments:
Oh dear. The Thin Mints are my downfall. Once you start, you can't stop.ReplyDeleteReplies
You do know Nestle makes a Thin Mint candy bar, right?Delete
Also, Tagalongs and Samoas too.
Holy shit holy shit holy shit, just found out they also make Nesquik Thin Mint flavored milk...and it's low-fat. Just what I'll need to wash down a metric fuckton of the cookies and candy bars. Diabetes here I come!Delete
I guess since I'll no longer be shamed by having to look at real life people selling me the cookies it's gonna be sweatpants for life.ReplyDelete
Now there will be no shame to my habit of amassing cases of Samoas to get through the winter.ReplyDelete
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text:
Thursday, December 20, 2012
wsj lies about education: in which i name names
on december 6, 2012, the wall street journal published the following completely false article under stephanie banchero's byline: students fall flat in vocabulary test. kevin drum wrote about banchero's distortions at the time, but banchero never corrected her article, which was absurdly backwards, whether because banchero deliberately lied or is ignorant I cannot say.
i commented in the wall street journal's comments section for that article at the time. my comment is no longer on the site. not only are the wall street journal and stephanie banchero not to be trusted, but they apparently remove comments that contradict their false hoods. i have tried to locate an email or other address for the wall street journal's ombudsperson, but i haven't been able to find one.
update: found the wsj corrections address, so i wrote to that address.
i commented in the wall street journal's comments section for that article at the time. my comment is no longer on the site. not only are the wall street journal and stephanie banchero not to be trusted, but they apparently remove comments that contradict their false hoods. i have tried to locate an email or other address for the wall street journal's ombudsperson, but i haven't been able to find one.
update: found the wsj corrections address, so i wrote to that address.
posted by DBK at 10:52 AM |
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text:
With a built-in light and outlets, this nightstand is the perfect bedside companion. A flip top panel hides outlets that make it easy to charge a phone or tablet overnight. A light located under the nightstand makes for a perfect nightlight, while two drawers and an open compartment offer simple bedside storage.
The Varsity Nightstand with Charging Station by Smartstuff in the Philadelphia, Broomall, Delaware Valley area from Baby Supermart. Contact us for the most current availability on this product.
Equipped to handle your modern lifestyle, this nightstand features an attached electrical outlet for safe and convenient device hook up. Charge your phone or tablet while you sleep, knowing your device is within reach for emergency calls, reading an e-book late into the night, or checking your email when you wake up in the morning. The outlet also works to reduce clutter, offering a simple connection for your bedside lamp or alarm clock that keeps your bedroom floor free of tangled and unsightly wiring.
Rooted in the spirit of Friday night football and carefree summer days, the Varsity collection has a timeless American feel updated for today's style and modern needs. The versatile collection is perfect for boys and girls of any age, with a brown Jersey finish and simple panel detailing that looks effortlessly classic. Designed for modern babies, kids, and teens, the collection offers tons of cool storage and function, with features like hidden storage, charging stations, and cork panels found throughout the bedroom collection. While kids will love the fun features and special Smartstuff stuff, parents will appreciate the brand's trusted safety features and durable construction. Whether in the cradle or about to graduate, Varsity is for children and families committed to playing hard and working harder, who understand the importance of superior storage solutions, timeless style, and innovative function.
The Varsity collection is a great option if you are looking for Casual furniture in the Philadelphia, Broomall, Delaware Valley area.
Browse other items in the Varsity collection from Baby Supermart in the Philadelphia, Broomall, Delaware Valley area.
This item has been tagged as:Nightstand, Night Stand, Commode, Bedroom Nightstand, Bedroom End Table, Accent Table, Accent Cabinet, Bedroom Storage, Bedroom Magazine Stand, Night Table, Small End Table, Night Stand with Drawers, Nightstand with Pull-Out Shelf, Night Cabinet, Bedside Table, Bedside Nightstand, Bedside Commode, Door Nightstand, Bachelors Chest
Baby Supermart features an astounding selection of baby furniture and kids furniture in the Philadelphia, Broomall, Delaware Valley area, and can help you with your home design and decorating. Whether you're looking for a new crib, changing table, or furniture for your child's bedroom, Baby Supermart has what you're looking for. We offer great baby furniture and kids furniture, at a low price to the Philadelphia, Broomall, Delaware Valley, Chester, Radnor area. With incredible brands like Smartstuff by Universal and Legacy Classic Kids, we have all design styles and a wide variety of made in America baby and kids furniture. Our knowledgeable sales associates will help to create the home of your dreams at a price that can't be beat. This makes Baby Supermart your one stop shop for kids furniture and baby furniture in Philadelphia, Broomall, Delaware Valley and the surrounding area.
Information Accuracy - We have taken great care to provide you with information that is accurate and useful. Please notify us if you find an error, and we will do our best to correct it. We ask that you contact us directly and visit our stores to confirm information about pricing, color, features, dimensions, availability and special order lead times.
M,Tu,Th: 10-6 W,F: 10-8 Sa: 10-5 Su:12-5
489 Park Way, Broomall, PA 19008
Nothing on this page may be copied or reproduced without explicit permission.


text:
We couldn't be happier to welcome a wine back into the store.
When we first tasted the Cotes du Rhone Plan de Dieu 2011 from Chateau Saint Jean, we knew we had something special. We grabbed as much as we could, expecting to have enough left to last us through the Holiday Season and through the winter. BOY WERE WE WRONG! Before November was over, we were already sold out and were desperately trying to grab more of this across-the-board favorite. Zachys staff members have been asking us "Where is the Plan de Dieu?" for months…and now the wait is over!
Rave reviews from the Sonoma Wine Journal, James Suckling in his "Zachys Wine Challenge", and from staff members and Zachys faithful alike have DEMANDED that we get as much of this wine as possible. So it's back...for now! This sold by the case last fall, and we expect it to once again. Phrases like "Truly Irresistible" and "Drink me" only scratch the surface of this fantastic value Rhone red.
In stock and ready to ship, lock in for your bottles now, because who knows how long we'll be able to hold onto it this time!
All My BestAndrew
The product has been successfully added to your cart.
Store Hours: Mon-Fri 10am-8pm, Sat 9am-8pm, Sun 12pm-5pm • Customer Service Hours: Mon-Sat 9am-6pm
16 East Parkway, Scarsdale, NY 10583
(914) 874 8000 • 1 (866) 922 4971 • fax (914) 723 1033 • firstname.lastname@example.com • Free Parking
Zachys prices are good while supplies last. Discount cannot be applied to previous purchases, futures or gift orders.
Offers cannot be combined with any additional promotion. Not responsible for typographical errors. Prices subject to change without notice.
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