text:
Identification of gene-oriented exon orthology between human and mouse
Selected articles from the Tenth Asia Pacific Bioinformatics Conference (APBC 2012)
The Tenth Asia Pacific Bioinformatics Conference (APBC 2012)
Gene orthology has been well studied in the evolutionary area and is thought to be an important implication to functional genome annotations. As the accumulation of transcriptomic data, alternative splicing is taken into account in the assignments of gene orthologs and the orthology is suggested to be further considered at transcript level. Whether gene or transcript orthology, exons are the basic units that represent the whole gene structure; however, there is no any reported study on how to build exon level orthology in a whole genome scale. Therefore, it is essential to establish a gene-oriented exon orthology dataset.
Using a customized pipeline, we first build exon orthologous relationships from assigned gene orthologs pairs in two well-annotated genomes: human and mouse. More than 92% of non-overlapping exons have at least one ortholog between human and mouse and only a small portion of them own more than one ortholog. The exons located in the coding region are more conserved in terms of finding their ortholog counterparts. Within the untranslated region, the 5' UTR seems to have more diversity than the 3' UTR according to exon orthology designations. Interestingly, most exons located in the coding region are also conserved in length but this conservation phenomenon dramatically drops down in untranslated regions. In addition, we allowed multiple assignments in exon orthologs and a subset of exons with possible fusion/split events were defined here after a thorough analysis procedure.
Identification of orthologs at the exon level is essential to provide a detailed way to interrogate gene orthology and splicing analysis. It could be used to extend the genome annotation as well. Besides examining the one-to-one orthologous relationship, we manage the one-to-multi exon pairs to represent complicated exon generation behavior. Our results can be further applied in many research fields studying intron-exon structure and alternative/constitutive exons in functional genomic areas.
With the increasing availability of genomic and transcriptomic data in numerous species, identifying orthologs and hence extending the functional characterization and gene annotation is of prevalence in comparative and evolutionary genomics. Orthologs are defined generally as genes originated from a common ancestor but are now found in different species after speciation
Alternative splicing (AS) is a crucial mechanism in the generation of multiple transcripts in functional diversity from a single gene loci in eukaryotes. It was reported recently that more than 90% of human genes could be alternatively spliced in various tissues and developmental stages
To address this issue, Ho
Based on such concepts, it is reasonable to advance the current concept of orthology to the exon level. Genes and transcripts are widely accepted as functional units and materials for orthology studies; however, both are composed of exons. An ensured orthology observed in a gene pair cannot guarantee the orthology of each exon inside. The exon orthology is in higher resolution compared to gene or transcript levels. Establishing the orthologous relationship between exons provides an alternative and detailed way to view the gene orthology, the extension to genome annotation, materials to study intron/exon gain/loss in evolution, and the association with alternative splicing.
However, through the literature survey, no existing report focused on building databases specialized to assignation of orthologous exons in whole genome, except an unpublished web database
There were also several studies mentioning the organization of orthologous exons, but they were by-products of researches in various fields and just in a partial coverage to genome. Zhang
Here, we propose a novel gene-oriented exon orthology database to demonstrate genome-wide orthology relationships at the exon level in human and mouse. Because of the ability to distinguish orthologs from in-paralogs and the considerations of alternative splicing, we choose Ho
Overview of process in orthologous exon database construction
From orthologous gene pairs provided from Gene Oriented Ortholog Database (GOOD), our previously developed genome level ortholog database
Figure 1
Process of generating human and mouse exon orthologs
Process of generating human and mouse exon orthologs. A. Flow chart of orthologous exon database building. B. Exons with N (N > 1) putative exon orthologs were further verified if these N exons belonged to the same united exon. C. Identification of fused and split exons through analysis procedure from putative orthologous exons. D. Confirmation of the correct orthologous exon pairs via anchor mapping for the rest of the putative orthologs yet to be verified.
Taken all together, we obtain a collection of anchors in 325,899 united exons and their orthology relationships are designated. The intron-exon structure is highly conserved between human and mouse was proposed in several previous studies
Orthologs between human and mouse
This study begins with 363,419 exons from human and mouse orthologs and assigns about 92% of exons with orthologous relationships, indicating that most of the exons hold reasonable sequence conservation between human and mouse (Table
Table 1
Summary of orthologous exon database
No orthologs
No hit
Ignored a
United exon
Here, 1->1 (one-to-one) indicates exons with only one ortholog whereas 1->N (one-to-multi) indicates exons with more than one orthologs. N represents any number that is larger than one. a putative orthologous exons determined as unreliable after verification and then were ignored in orthologous exon identification.
Distribution of orthologous exon pairs
We further examined the orthologous exon pairs according to the physical regions in which they reside in the gene. Six categories are defined: 5' UTR, 5' UTR with partial coding region, coding region, 3' UTR with partial coding region, 3' UTR, and single long region across 5' UTR, coding region and 3' UTR (SLR). The SLR indicates a united exon that extends from 5' UTR to 3' UTR. In the analysis of distribution in gene regions, the orthologous exons tend to have a higher ratio in coding regions compared to those without orthologs, as expected. In contrast, united exons without orthologs are located more in untranslated regions; for instance, ~39% are in pure 5' UTR, but only 1.67% of united exons having orthologs are in the same place, as shown in Additional file
Additional file 1
Summary of united exons in different gene regions .
Click here for file
Figure 2
Distribution of united exons with and without orthologous pairs in different gene regions
Distribution of united exons with and without orthologous pairs in different gene regions. The x-axis represents the gene regions in which united exons are located, and the y-axis is the percentage of united exons with or without orthologs to the total number of united exons in each category. SLR means a single long united exon extending from 5' UTR to 3' UTR.
Orthologous exons in coding region
Exons in an orthologous pair certainly have good similarity in sequence. Our investigation reveals that they have conservation in boundary and nucleotide length as well. In this particular analysis, only united exons with a single ortholog (330,541) are included. About 74% (244,474) of united exons of interest have the same length; many of them fall in the coding region shown in Additional file
Additional file 2
Distribution of one-to-one orthologous pairs in different regions .
Click here for file
Figure 3
Comparisons of united exons with or without length conservation to their orthologous pairs from human and mouse
Comparisons of united exons with or without length conservation to their orthologous pairs from human and mouse. Only one-to-one orthologous pairs are analyzed in this figure. The x-axis indicates the gene regions in which the united exons are located. The SLR tag means that the united exon crossed through 5' UTR, the coding region, and 3' UTR. The y-axis represents the number of united exons in two categories (with equal or unequal length to orthologous pairs) normalized to the total number of united exons in each gene region.
Reading frame correlation between orthologs
It is well known that an insertion/deletion whose length is not a multiple of three in protein coding region might trigger a reading frame shift and change the subsequent codons. Regarding united exons without length conservation to their orthologs, we estimate the influences caused by insertion/deletion events. About 26% (86,067) of united exons are of unequal length in orthologs pairs; the differences of lengths are analyzed. Figure
Figure 4
Analysis of length differences between orthologous pairs of unequal exon length
Analysis of length differences between orthologous pairs of unequal exon length. A. Distribution of remainders of three in length differences between orthologous exon pairs with unequal length. The MOD 3 = 0 category means that the remainder is zero when the length difference between exon orthologs is divided by three, and so on. The x-axis is the region in which the united exon is located, and the y-axis indicates the percentage of orthologous pairs with unequal length in each region for each category. B. Distribution in counts of united exons where length difference is less than or equal to 30 base pairs compared to orthologous exon pairs.
Fused and split exon pairs
Introns hold a larger part of the genome than exons and evolve more quickly. Thus, many events of intron gain and loss must occur during evolution, resulting in a possible exon fusion or fission
Additional file 3
Summary of all fused/split exons found in orthologous exon database.
Click here for file
With the rapid increase in transcriptome data by expressed tag sequences (EST) and next generation sequencing technology, it becomes important to enlarge the functional annotation to genomes. The assignment of gene functions through orthology is one of the bioinformatic approaches; many efforts have been made to improve accuracy. Recently, transcriptome data have been adopted in the study of orthology to address shortcomings in genome. It is advantageous for its depth and coverage of alternative splicing isoforms. In addition, more and more exon and intron information is being accumulated from transcriptome data, leading the potential to enhance the orthology relationship from the gene/transcript level to the exon level. We utilized the orthologs in GOOD as source materials and propose a new database to identify orthologous relationships in exons between human and mouse. The exons used in our work were derived from reference sequences provided by GOOD; consequently, the comprehensiveness of our database is correlated to the richness of reference sequences and of the GOOD dataset. Since RefSeq database is a subset of transcriptome data in species, the collection of exon information in our study is confined by RefSeq. However, ESTs are thought to contain a large numbers of erroneous and DNA fragments. RefSeq is considered the gold standard for gene and genome annotation.
There are about 7% of non-overlapping exons that can't find orthologs in our algorithm (Table
The second reason of not finding exon orthologs is originated from sequence divergence in evolution or the limitations in sensitivity and specificity of our algorithm. Human and mouse are organisms between a certain evolutionary distance, and of course some exon sequences have accumulated lots of variations in sequences, especially in untranslated regions. Reasonably, our pipeline might cause false negative detection as well. In observation of real data, we did find out some false negative cases by performing other pairwise alignment programs.
Thirdly, species-specific exons or recently born exons after speciation also lead to the similar phenomena and they are more of biological meanings. The 8th united exon (EXH_1087295) of 138 base pairs, in human nuclear prelamin A recognition factor (NARF, GOODH_1170481) is reported to have no any ortholog in mouse according to our finding, but it is not caused by the shortness of exon information. Sorek
It is not rare to see tandem segmental duplications within genes
Currently, human and mouse hold the most abundant transcriptome data; that is why we chose to build a prototype of exon orthology database based on these two species. The completeness of the transcriptome data affects the applicability of our work; as a result, it is certainly of importance to increase gene and transcript annotation to help the identification of more exons.
Orthology study should consider the exon level in order to provide more detailed relationships of the species under gene and transcript structure. Starting from a well-processed orthologous gene collection, we present an abundant and informative database that aims to delineate the exon orthology of whole genomes from human and mouse. We identify over 92% of united exons with orthologous pairs; this outcome can be thought as further gene annotation. Our strategy and consequence provide a new way to evaluate orthology at the exon level and have applications in several fields, like exon-intron structure among evolution, difference in alternative and constitutive exons, intron gain/loss between species and newly born/duplicated exons.
Human and mouse gene ortholog pairs
The orthologous gene data were mainly derived from the previously reported Gene Oriented Ortholog Database (GOOD)
Putative identification of orthologous exons by Blast search
For each gene, we extracted sequences of every individual exon and transformed them into small Blast databases accordingly. To locate the pairing exon, human exons were used to perform a BlastN search against their mouse orthologs, and vice versa. The total number of BlastN search in human and mouse were 184,580 and 178,839, respectively, equal to the number of exons appeared in 16,545 gene pairs. We selected an expect value of 1e-5 as a threshold to determine a reasonable BlastN hit, resulting in 157,975 human and 156,757 mouse exons having significant hits. The rest of the exons were thought to contain more divergent nucleotide sequences; hence, tBlastX was used for the subsequent search procedure. There were 26,605 human and 22,082 mouse exons run in tBlastX but only 11,276 human and 11,099 mouse exons having significant results under the expect value of 1e-3. The remaining 15,329 human and 10,983 mouse exons did have not any Blast hit using the two-step mapping protocol. In the end, we obtained 337,107 exons (169,251 in human and 167,856 in mouse) that were mappable to their orthologous genes.
United exons
Here, an exon is defined as a unique pair of genomic coordinates from alignments between all isoforms of one gene and its genomic loci. Thus it is reasonably normal to observe exons sharing one boundary in common or significant portions of a sequence due to alternative splicing or start/stop site selection. For example, gene GOODH_1010092 (PRDM2) has three transcripts, and its exon EXH_0101125 and EXH_0101131 are 20 base pairs differing in the 5' end because of alternative 3' acceptor sites. For these overlapping exons, the complexity of building orthologous relationships between human and mouse exons increases, as it results in one-to-multi connections. Therefore we adopted the longest part of the overlapped exons as united exons to represent the common region between transcripts to simply orthologous exon relations (Figure
Identification of orthologous exons
After merging BlastN and tBlastX outcomes, we obtained 351,789 putative exon pairings. Since the Blast hit does not indicate the orthologous exon directly, a further verification step is needed. First, we started with exons having only one hit and examined their backward relationship. If two exons in one pair both had only one hit and are Best_Reciprocal_Hits (BRH) to each other, then they were defined as one-to-one (1-1) orthologs. The total number of exons with one Blast hit is 329,591; after examination, 319,046 exons were confirmed in this step.
For 1-N exons, we checked if these hit exons belonged to the same united exon. If their backward search also linked to the original exon, then these exons were designated as orthologs. This step began with 4,125 exons but acquired 10,428 exons as 1-1 united exons, leaving 374 exons as unconfirmed due to backward relationships that did not fit (Figure
During evolution, one exon may split into more than one exon or exons may fuse into one; such events have stringent constraints in exon length and this characteristic can be used to determine exon fused/split cases
Assignment of the remaining exons via anchor mapping
In the previous step, we confirmed 329,691 exons (90.72%) with their orthologs in the other genome. These identified exon pairs were used to help assign the rest of the unpaired exons. There are still 7,416 exons (2.04%) unconfirmed in the Blast hits, so we needed more information to assist in ortholog designation. We assumed that the upstream and downstream exon of a given exon should hold similar arrangements in its orthologous gene pair
For each unconfirmed united exon, its order in the gene was retrieved from the database. The most closed upstream and downstream anchors of the given united exon were searched, and the positions of the corresponding anchor pairs were extracted from the other species. Figure
Overall 5,819 united exons were confirmed with orthologous pairs and 1,200 were abandoned in this step; 777 cases are lack of anchors and 423 ones have no in-order hit. Combining all filtering work, 8,935 Blast results were ignored and not adopted in the identification of orthologous exon pairs.
Exon orthology; alternative splicing; exon duplication; intron-exon structure.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
GCLF constructed the whole dataset, analyzed the data and wrote the manuscript. WCL supervised this study and helped to edit the manuscript.
This study was supported by grants from Academia Sinica and the National Science Council of Taiwan.
This article has been published as part of
Orthologs, paralogs, and evolutionary genomics
Integrating genomic homology into gene structure prediction
Comparative ab initio prediction of gene structures using pair HMMs
The conserved exon method for gene finding
Database resources of the National Center for Biotechnology Information
Gene-oriented ortholog database: a functional comparison platform for orthologous loci
Designating eukaryotic orthology via processed transcription units
Ensembl 2007
Inparanoid: a comprehensive database of eukaryotic orthologs
The COG database: an updated version includes eukaryotes
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Alternative isoform regulation in human tissue transcriptomes
Assessment of orthologous splicing isoforms in human and mouse orthologous genes
Refining orthologue groups at the transcript level
Primate Orthologous Exon Database
Divergence of exonic splicing elements after gene duplication and the impact on gene structures
Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss
Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes
The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species
Tandem exon duplication tends to propagate rather than to create de novo alternative splicing
Basic local alignment search tool
Exalign: a new method for comparative analysis of exon-intron gene structures
Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?
Common exon duplication in animals and its role in alternative splicing
The birth of new exons: mechanisms and evolutionary consequences
Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons
MicroRNAs: target recognition and regulatory functions
Widespread and subtle: alternative splicing at short-distance tandem sites
Characterization of intron loss events in mammals
Evolutionary origin and functions of retrogene introns
Current topics in genome evolution: molecular mechanisms of new gene formation
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
The UCSC Genome Browser database: update 2010


text:
GOP needs tough love in '16 cycle
WASHINGTON — "If Reince Priebus from Kenosha, Wisconsin, is the Republican 'establishment,' God help us," says the chairman of the Republican National Committee, Reince Priebus. His physical presence is almost as unprepossessing as James Madison's was, and his demeanor is self-deprecating. But with meticulous — Madisonian, actually — subtlety, he is working to ameliorate a difficulty that has existed for two centuries and in 2012 wounded the GOP.
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Cat rescued after 3 winter days in Ohio drainpipe
FINDLAY, Ohio — A cat that spent at least three winter days in a northwest Ohio drainpipe has been rescued after initially refusing attempts to lure it out with tuna, the classic call of "here, kitty, kitty" and even a cellphone app that meowed.
The Courier newspaper (http://bit.ly/1d9g89t ) reports a resident in Findlay heard the cat's cries Wednesday. Groundskeepers at a school cut through the pipe Friday to free the orange cat, which was muddy, emaciated and hypothermic.
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Dolmen Hotel
Select your stay dates to check availability at Dolmen Hotel
Dolmen Hotel
About the Hotel
Property Location
With a stay at Dolmen Hotel, you'll be centrally located in Buenos Aires, steps from Ruinas de San Ignacio and Palacio Paz. This hotel is close to Teatro Colon and Obelisco.
Make yourself at home in one of the 145 air-conditioned rooms featuring minibars and LCD televisions. Complimentary wired and wireless Internet access keeps you connected, and cable programming provides entertainment. Bathrooms have complimentary toiletries and bidets. Conveniences include laptop-compatible safes and desks, and housekeeping is provided daily.
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Featured amenities include complimentary high-speed (wired) Internet access, a 24-hour business center, and express check-in. Event facilities at this hotel consist of conference space and meeting rooms. Self parking (subject to charges) is available onsite.
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- Babysitting or childcare
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- In-room accessibility
- Multilingual staff
- Tours/ticket assistance
- Poolside bar
- Free wired high-speed Internet
- Babysitting or childcare (surcharge)
- Laundry facilities
- Designated smoking areas
- Elevator/lift
- Free breakfast
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- Rooftop terrace
- Free WiFi
- Total number of rooms - 145
- Luggage storage
- 24-hour business center
- Restaurant
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- Express check-in
- Self parking (surcharge)
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- Premium TV channels
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Know Before You Go
- Children 10 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.
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The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.Show all hotel policy Show less hotel policy


text:
At first sight, residential property investment might not seem attractive. After all, to get anything like a decent house you need a lot of money, particularly in the South.
In fact, this sort of investment is easier than you might think thanks to the increasing number of buy-to-let schemes available from banks, building societies and other lenders.
The appeal of such schemes is that while you are renting out a property you earn a good income; 10 per cent of the purchase price, before costs, is a reasonable annual expectation. Then, when you sell, you could make a decent capital gain.
Around 30 lenders offer mortgages for investors buying to let. That includes seven members of the Association of Residential Letting Agents (Arla), a group set up in 1996 to promote buy-to-let schemes.
Arla helps prospective landlords find properties, though to use its scheme you must borrow from an Arla member and use the money to manage the property. It is possible to borrow up to 80 per cent of the purchase price of a property.
Lenders usually offer loans on the basis of the rent you will be able to secure from a property, rather than studying your income. Several, for example, require a potential gross monthly rental income of at least 130 per cent of the monthly mortgage payment.
The rates on buy-to-let mortgages are typically slightly higher than those on conventional loans. But Ray Boulger of John Charcol, the mortgage broker, says buy-to-let interest rates are falling steadily: "There are some very competitive fixed-rate mortgages available."
John Charcol has been offering buy-to-let loans with an annual interest rate fixed at 6.95 per cent for five years. Simon Tyler, at Chase de Vere, is offering deals at 6.75 per cent fixed for 10 years. Variable rates are available too, so investors must decide whether to opt for certainty about the size of future mortgage payments or whether to bet on interest rates falling in the coming years.
First, however, you need to find a suitable house. "The return on investment properties is very different around the country so location is very important," says Mr Boulger. In general, he adds, London and the university towns offer the best returns, with properties in rural areas being less attractive.
Investors also need to decide whether to appoint an agent to manage a property. Letting agents offer valuable help as they will find and liaise with tenants, sort out the legal issues and collect the rent. The downside is that you will typically have to hand over 15 per cent of each month's rent to your agent as a fee for the work.
Residential property investment is not without risk. Whatever happens, you will have to pay the mortgage, so it is important to keep your costs low. Expect normal running costs, including insurance, to reduce your 10 per cent annual yield to 7 to 8 per cent. There is also the possibility of unexpected costs such as a repair bill. Moreover, if one tenant leaves and it takes time to find a new resident, you will also lose out. In the worst case, you may have to pay legal fees to shift a tenant who does not pay the rent.
Then there is tax. A second home that you rent out is classed as a business asset. So you will have to pay tax on your rental income, though you can set mortgage interest and other costs, but not the cost of furnishing the house, against this.
You may also have to pay capital gains tax on any profits you make when you sell.
It is by no means certain you will make a profit on the sale of your property. House prices have soared in recent years but don't forget the negative equity crisis a few years ago.
If you are investing for the long term, you stand a good chance of reasonable gains, but don't depend on it.
Buying to let is still a potentially attractive investment, not least because of increasing demand for rented accommodation.
At the same time supply is limited. Just 10 per cent of the UK housing stock is currently rented compared with 30 per cent or more in most European countries.
Contact: Arla, 01923 896555.
David Prosser is features editor of `Investors Chronicle'.
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{image-madhya pradesh_26072008.jpg news.oneindia.in}Bhopal, Jul 26: More than 1.60 lakh forest dwellers and tribals in Madhya Pradesh have so far filed their claim for allotment of title deeds of land in their possession under the Scheduled Tribes and Other Traditional Forest Dwellers (Recognition of Forest Rights) Act 2006 and Rule-2008.
The state government has chalked out a time-bound action plan for effective implementation of the scheme vis-a-vis filing of claims, survey and claim verification, official sources said. As many as 33,068 claims have been received in Bhopal division, 6428 in Hoshangabad, 21910 in Indore, 2593 in Ujjain, 1953 in Chambal, 31467 in Gwalior, 3442 in Sagar, 20236 in Jabalpur and 38,981 in Rewa division.


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Top Bond's Boats!
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Bond's Top BoatsAs Bond is definitely no stranger to
taking to the water in his relentless pursuit of henchman and villains alike, perhaps a more aptly fitting sanction would be a 'License to Sail'. In homage to SPECTRE , yacht charter specialists The Moorings have put together a fun interactive web page where you can now search for the most iconic and, in some cases, unrecognisable James Bond Boats .
For example, Q's "Fishing Boat"...
Featured in:
Special Features:
- Rocket Propulsion
- Heat Seeking
- GPS Tracking System
- Can negotiate land
and dive underwater
- Customer fitted
with an air cannon for the final scenes where the boat was launched out of the water
- 15 versions were
created in total
There are other behind the scenes facts available for each of the iconic boats selected and a 5 star rating system judged by an independent Bond fanatic.
Check it out to see if you agree!


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Bechar Gifts For Host Family
18 items found
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Words formed when one letter is changed in me
Letter 1 (M) changed: 10 words found:
Letter 2 (E) changed: 6 words found:
A total of 16 words can be formed from me by changing one letter.
Some random words: glabella etcetera doer bepaint keir aiglet re
This is not a dictionary, it's a word game wordfinder.
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Research Activities
Research Activities
Principal Investigators
Dept. of Life Science Frontiers
Hirohide Saito (Professor)
Hirohide Saito Ph.D.
[ Contact ]
Research Overview
Research in the synthetic biology field, which attempts to bring about new technologies by understanding life through the process of "artificially creating" biomolecules and biological systems, is becoming established worldwide. Creating artificial biomolecules that freely control the functions of cells and applying them to examinations and medical treatments is one of the research goals of this new field. Our laboratory will use the unique technology of synthetic biology that molecularly designs RNA and/or RNA-protein complexes (RNP) artificially, assuming various functions in vivo, and experimentally evolve them* in order to develop a new technology that will allow the functions and fate of target cells to be freely controlled. Moreover, along with developing such new technologies, in order to understand the evolution/creation of biological systems, we aim to experimentally approach the fundamental questions of "What is life?" and "What are the structural principals of cells?" In concrete terms, we will engage in research subjects such as those listed below.
1. Developing a detailed/dynamic technique to differentially induce iPS cells into target cells with high safety and purity using artificial RNA/RNP
2. Developing an artificial RNP switch that can detect specific protein expression and control ON/OFF of the translation of target genes
3. Developing a multifunctional RNP nanostructure that specifically perceives/detects/controls target cells


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The Russian connection: See all our coverage | Read about our investigation
President Obama just signed executive orders prohibiting any of his current and future administration officials from leaving office and then turning around to lobby the administration on the issues of his or her expertise. This ban is in place not for two years, not for four years. It is in place for the full length of Obama's term in the White House. In a statement, Fred Wertheimer, president of good government advocacy group Democracy 21, called the move "the toughest and most far reaching revolving door provisions ever adopted." (For the full slate of new ethics rules, click here. For Wertheimer's full statement, which is almost gleeful, click here.)
Asked for comment, John Wonderlich of the Sunlight Foundation said that while he's waiting to see the details, "today's announcement is a significant shift in the executive branch's stance toward being held accountable to the public it serves." He called the move "very encouraging."
And it's not just encouraging for open government reasons. It's also smart politically. If you create a culture where industry shills can't run or work in Interior, the FDA, the EPA, and other federal agencies, you're left with a pool of civic-minded people who care about reform, regulation, and the environment to choose from when making appointments. It will be tough, one would assume, for a Republican president to change that culture in eight years. I think it makes the bureaucracy, on balance, less corporate and more progressive.
President Bush didn't just let former lobbyists work in his administration. He let them run entire departments. And he let current lobbyists make policy. That era is over. Decisively.


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Contrary to popular belief, Pelle Tornberg did not invent the free daily commuter newspaper. In fact the genial Swede actually recommended against producing such a title when he was president of Kinnevik Media in the early 90s. Tornberg loved the concept pitched to him by two men from Sweden's top-selling morning paper, but he figured Kinnevik had its hands full with radio and TV. His entrepreneurial boss, Swedish media and telecom mogul Jan Stenbeck, thought otherwise. "The chairman said 'sorry, you're completely wrong, let's do it'. And here I am still suffering!" Tornberg jokes.
Despite his initial hesitation, the former broadcast journalist is now closely identified with the freesheet revolution, having driven the phenomenal growth of commuter papers around the world as the head of Metro International. Starting with just one free newspaper in Stockholm in 1995, Metro International publishes 59 editions in 83 cities today. You can pick up a copy of Metro in New York, Hong Kong, Rome, St Petersburg and Santiago. But not in Britain - the Metro that is distributed in London and other major UK cities is published by Associated Newspapers. The Daily Mail owner opted to start its own UK freesheet in 1999 rather than lose readers to a Swedish-owned version.
Tornberg, who runs Metro International from an office in Mayfair, still covets a foothold in Britain. "London is certainly of interest," he says. "London is a brilliant newspaper market. It's one of the few places where you benefit from reading more than one newspaper."
Under Tornberg, Metro has successfully adapted its freesheet formula to suit different cultures. Its continued growth in readership and advertising revenues has raised questions about the future of paid-for titles and unnerved British media players. Boasting more than 15 million readers around the world today, Metro is the most-read newspaper outside of Japan. Its titles have a combined circulation of 5.1m in Europe, dwarfing the 3.7m copies Germany's Bild sells, and the 3.2m sold by the Sun. Targeting the young urban professionals so sought-after by advertisers, Metro has seen its revenues soar from $9.6m (£5.6m) in 1995 to $302m (£175.5m) last year.
Tornberg attributes Metro's success to its strict editorial formula, and its "scientific" approach to distribution. The standardised editorial style and design of the papers ensures Metro provides advertisers with a consistent product. "We have a lot of control mechanisms. It is absolutely important to stay neutral, to have the same editorial line in all countries."
As it does not charge a cover price (which many papers only break even on anyway), Tornberg argues Metro has no need to hype stories. "If you give away something for free you can actually do a very decent paper. We don't need to put bikini girls, crime, on our front page to sell papers." But he acknowledges the model has limitations. "If you have a strong editorial line you could change things, which is one of the duties of a newspaper I think. Metro [is] not here to mobilise readers."
Tornberg once described Metro as the Big Mac of newspapers. But that was before a French columnist told him McDonald's was hated in many countries. Now he prefers the term "glocal". "Metro has the same editorial line, layout, template [around the world], but every Metro is perceived as being a local newspaper," he says. The company modifies its distribution system to best reach commuters in each market. Less than 30% of Metro copies are distributed on public transport: the papers can be found in any "high commuter traffic zone", including shopping malls, offices, universities, libraries and Italian coffee bars. It is a huge operation: 7m copies are printed each night at 53 plants and then delivered by 500 trucks to 3,200 hand distributors and 22,000 racks.
Metro's international expansion has not been without its teething problems. In the Czech Republic it was forced to employ guards to give out the paper in train stations, after it discovered old women were pilfering 100 copies at a time to take back to their villages and sell. "We created a lot of entrepreneurs," Tornberg says. Meanwhile, stiff opposition to the freesheet in France forced Metro to print its French editions in Luxembourg, then drive them over the border. "There is always this local twist which can sometimes take a little bit of time to find."
Like the internet, the Metro freesheet model has fuelled the notion that news is free, much to the horror of paid-for titles which are losing readers and advertisers. "Journalists are probably the most conservative people in the world," Tornberg says. "They love to write about change, but they hate change happening to them."
But he agrees that newspapers are facing a "scary" future. He blames the plight of the paid-for press on the "semi-monopoly situations" they have enjoyed for too long. "They've been fat cats, they haven't done a good job." Tornberg still expects 95% of paid-for newspapers to survive, albeit in a niche capacity. "If you apply the pay TV and free TV [model] to the newspaper industry, then the paid-for newspapers probably have to accept living with smaller circulation and probably increasing their prices, increasing the exclusivity." He believes paid-for papers are "unbeatable" when it comes to providing opinion, comment and analysis. More chillingly for newspaper editors, Tornberg predicts a time when commuter freesheets will replace the weekday editions of paid-for papers, and readers will only pay at the weekend.
Right now he is concerned that the distinction between free and paid-for newspapers is becoming increasingly blurred. At a time when paid-for titles are cutting editorial staff to improve profitability, Metro International is hiring more in-house reporters and reducing its reliance on wire copy: "It's a dangerous situation now we're starting to fight with the same weapons." But Tornberg is amazed Metro has not encountered more opposition from the paid-for papers. The New York Times is actually one of the biggest advertisers in its local Metro edition. And in cities such as Stockholm the arrival of the freesheet has increased readership of newspapers overall. Tornberg attributes this to changing habits - people are now more likely to read their paid-for newspaper in the evening, and scan a copy of Metro in the morning: "Before Metro they were probably reading the Kellogg's packet."
Metro has conquered most of continental Europe, most recently arriving in Russia and Portugal, but so far Germany has eluded it. Competition is much tougher there, and the Germans have proved more disciplined than their neighbours at banding together to keep Metro out of the market. "Very often in Europe many media companies are family-owned. They are very often fifth- or sixth-generation family members. They tend to be very excellent at playing golf," Tornberg says. "Germany, because of the second world war, they are only second-generation, they are very rich, they work hard, they are very smart."
Metro remains determined to crack Germany, and it has also been negotiating to enter China. "We [Europe] are the past, they are the future," says Tornberg. Metro is keen to expand into other cities in Russia and the US, and elsewhere in South America. "It's a combination of focusing on existing titles and expanding quite aggressively in existing markets as well."
Metro expects to turn a profit in each market it enters within three years, and Metro International is likely to make its first profit as a group this quarter. In markets where it has been established for more than three years, the paper typically enjoys 22% revenue growth and 10% profit growth. The company is also branching out into real estate and car supplements, and expanding its online presence.
There are only two developed countries that Tornberg rules out. One is Singapore, where the media are restricted and foreign ownership is limited to 3%. The other is Australia, where Rupert Murdoch is already publishing free commuter dailies in Sydney and Melbourne. "It's probably the most competitive market in the world, with very emotionally driven, strong, rich players," Tornberg says.
But the $64,000 question is when will Metro finally enter the UK? There is talk it could set up a joint venture with its one-time rival Associated: the pair already have a deal to sell packages of advertising across their papers, and they teamed up to launch Metro in Dublin last month. A financial newspaper has been mooted (although CityAM recently beat them to it), as has a joint pitch for the rights to publish a London afternoon freesheet.
Tornberg believes Metro's straight editorial style would be a particular advantage in Britain, where each newspaper has such a distinctive bias. But he downplays the company's interest in bidding for the London afternoon paper slot, citing the failure of Metro's Swedish afternoon experiment. "The afternoon newspaper market is weakening all over the world. Advertisers prefer to go to TV in the evening. It's not about information [at that time of day], it's about entertainment."
Metro will bide its time. It took nine years of negotiations to gain a foothold in the US, and seven years to get into France. "People think we are in a rush - we haven't been in a rush," Tornberg says.


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Title: Coming Down
Summary: In a chemical experiment, Holmes discovers crack cocaine and learns about its properties the hard way... meanwhile Watson has news he is afraid to share with Holmes. Watson/Holmes friendship
Spoilers: Both films (truly, this time!)
"Coming down...is the hardest thing" - Tom Petty
"You have a patient near Baker Street. Why not drop in on Sherlock Holmes? You haven't seen him for a while..." Mary suggested to her husband over breakfast.
"You know as well as I do that if I go and see him, he will drag me into another adventure..."
"He drags you, does he?" Mary said drily, giving him a knowing smile. He had the grace to look sheepish but continued regardless."...and right now, I need to be here for you. I can't go chasing adventure in Turkey or Morocco or Russia, hoping to come back in one piece." He finished, but he knew Mary was right.
"It goes without saying that I will worry about you being in danger." Mary said, spreading some marmalade on her toast. "But I'm also concerned about you avoiding your closest friend."
"I'm not-"
"John. Please. I am pregnant but still perfectly capable of taking care of myself. If you're going to avoid Holmes- at least be honest about the reasons." He ignored the nagging guilt he felt.
"Mary...the last case put you in danger. As if that wasn't enough to make me think twice, now you're with child..."
"Yes, I'm with child. And you're putting off telling him. But you will have to at some point." She sighed and put her hand on his, looking into his eyes. "Just think about it, will you? I don't think he has anybody else."
She stood, and left the room to attend to something else. On his way out of the house he gave her his usual parting kiss.
"You are right, as usual. I'll stop by after this patient."
She smiled at him and he looked at her belly at 5 months, before giving her a fond "Take care" and leaving.
"Holmes?" John cautiously entered the room, knowing that anything could be inside. It would barely have surprised him to find a lion, or to find the entire room filled with water...
He didn't immediately spot his friend amid the debris that had once been their shared rooms. Debris was the only word for the place as it stood- looking as though a bomb had gone off. John picked his way through and jumped when Holmes leapt out from behind a pile of junk, eyes wide and intense, and half-shouted his name.
John started in shock. He had a couple of seconds to establish that his friend was in serious trouble before Sherlock made his way over to him and put his hands on his shoulders.
"Watson - it's good to see you! I've made a discovery!"
John's doctor instincts kicked in as he took in the sight before him. Sherlock's arms were bleeding badly from multiple lacerations, and it was clear that he had taken some drug or drugs very recently. He looked even thinner than usual, feverish, and as though he hadn't slept in days. The most likely candidate, he supposed, was cocaine - the worst he'd ever seen his friend on the drug. It scared him more than he would admit.
"Holmes - what are you doing? What have you done to your arms?" he reached out to look at them more closely but Sherlock jumped out of his reach.
"There were insects, Watson, under my skin. I think they're out now. I'm not sure... you look alarmed - are you running from somebody? A gambling debt perhaps?"
"No, Holmes, I came to see you. I-"
"Why? Who sent you? Mrs Hudson? She's been acting suspiciously lately Watson - I wouldn't trust her if I were you. She's been trying to poison my food again."
"You seem to be poisoning yourself without any help whatsoever..." Watson stated harshly, trying to quell the fear-driven anger he felt at Sherlock's reckless behaviour. But his concern grew the more he exhamined him.
"I can do whatever I want" Holmes snapped, picking up a book and throwing it against a wall. John catalogued the symptoms: hallucinations, hot and feverish, mood swings, restlessness, paranoia, over-confidence, erratic and unpredictable behaviour...it had to have been cocaine. The detective started picking up everything around him and throwing it across the room, from books to test tubes to plants.
"Watson!" Holmes mimicked. "Who sent you? Hm? I haven't seen or heard from you in approximately 5 weeks and 4 days. I have no new case of interest to you. So why are you really here? There's no point lying - your clothing tells me you are in the area to see a patient."
"Yes, just a few streets down. A young lady with a cold." Watson felt uncomfortable, knowing that Holmes was extremely unpredictable at the moment.
"A cold?" he laughed. "Surely you are above such trifling matters!"
"It turned out not to be as serious as her family thought. At the moment I'm more concerned about-"
"Really? And what then - your cab mysteriously broke down and you had to walk here for a phone?"
Watson hesitated, unsure how Holmes had deduced so much from so little. "Yes. But-"
"That mystery is settled then. Mycroft sent you."
"Mycroft?" John said, baffled.
"He's always meddling from afar..." Sherlock said with scorn.
"You think Mycroft set this all up so I would come here?" As he said it, he realised that his arrival at 221B did seem remarkably serendipitous. He felt a mixture of guilt at having to be prompted to call on his friend, and surprise that Mycroft was keeping an eye on his younger brother despite his rather 'hands off' approach to it.
"No Watson, I know it. I know my brother's methods as well as my own. Besides, you would never come here on your own - you have your wife and no longer wish to associate with me."
John's heart sank at the words.
"So now that you are here Watson, what do you want?" Sherlock started viciously scratching his already bloody arms, "Goddamnit how do they get underneath the skin? It hardly seems possible..."
"Holmes stop that!"
"Don't tell me what to do!" Holmes shouted, and Watson thought he had never seen his friend so unstable before. He swallowed.
"I apologise...I didn't mean to shout... It's hot in here I'll open the window." Holmes said, suddenly contrite.
"...I had already decided to call without your brother's interference. It just shows that he's as worried about you as I am. Either way, it's a good thing I came."
"And why's that?"
"Because I can see that you've been slowly but surely killing yourself in my absence!"
"What absolute nonsense you talk Watson! I've never felt better." he was frantically looking for something, John guessed it was more cocaine.
"It would seem I have to go out for supplies soon." he said, making his way towards the door that John was blocking.
"No." John said quietly. "I won't allow you to do this to yourself. I only found out that you weren't dead a few months ago - I will not lose you again."
"And pray, what authority do you have over me?"
"As your doctor and your friend, Sherlock, I WILL NOT lose you again!" John shouted the end, hurting and angry that his best friend could be in this state. He was frustrated, and scared. He didn't know if he had a right to be angry, but he was - both at Holmes and himself - and he bit down on the tears that suddenly threatened.
"You are angry with me, Watson. Perhaps that's why you haven't called" Holmes said faintly, before collapsing.
John knelt beside his friend quickly and checked him over. His heart-rate was too fast, and he was burning up. His arms had several knife cuts on them, some of which would need stitches. John quickly bandaged the worst of them before Sherlock woke up again, apparently unable to keep still.
"I'm fine, felt momentarily dizzy but I'm fine, really you must stop fussing."
"Your temperature is dangerously high." Watson thought out loud, going to retrieve some cold water and some material to cool Holmes down. He came back to find Holmes still in the same position and started cooling his face.
"Now that I've discovered it, this is rather a good location." Holmes said lazily. John knew he was starting to come down from the high. Could see unconsciousness from blood loss and lack of food pulling on him.
"You won't leave, will you Watson?"
"I won't leave." John said, trying not to voice the sadness he felt at that moment. His best friend, who could be at times so awe-inspiringly brilliant, and so selflessly courageous, could also find himself in a state such as this. He had failed to take care of him as a doctor or a friend, and now the most gifted consulting detective in quite possibly the world, was lying on the ground, in a mood that was rapidly deteriorating. John knew he would descend into depression and lethargy, and that it could last for days.
He promised himself he'd be here for his friend. He thought of Mary, and knew she would understand. He realised suddenly that he didn't have to worry about the capable woman he'd married, he could spend this time trying to fix things with his best friend, whom he'd thoroughly let down.
"I didn't mean what I said about Mycroft." Sherlock said softly, laced with guilt.
"I know old boy. You're not exactly in your right mind at the moment." John said, automatic bedside manner taking over.
"He really is, the best brother one could ask for." he added. John felt surprised by the uncharacteristically open affection between two individuals who were usually so distant, so emotionless. He saw now that the love between the two brothers was understated, but profound.
John kept trying to cool Holmes down, finally he picked him up and took him to the sofa by the window, opening the window wide until he himself felt a bit too cold. Holmes was alarmingly light. There was a light tap on the door and Mrs Hudson peaked round.
"How is he?" she asked kindly. John knew that despite everything, she was fond of Holmes.
"He'll live. Do you know when he last ate?"
"He wouldn't eat my last two meals, Doctor, as far as I know he hasn't eaten for the last two days. I tried but he became so...well, unpredictable. Even more so than usual I mean. I was on the verge of calling you..."
"I'm sure you did all you could. Could you please telephone my wife and tell her that Holmes needs my professional help for a few days."
"Of course." She disappeared, turning a couple of pieces of furniture up the right way on her way out.
John rubbed his hands over his face. He evaluated if Sherlock needed hospital. He had slipped into unconsciousness, was dangerously dehydrated, malnourished, and anaemic. A hospital could do no more than he could do here, and it would cause Holmes less disruption, and later embarrassment. He decided that Sherlock had not lost so much blood that he would risk a blood transfusion, which he knew from experience could end up being fatal to the patient.
He got out his medical kit and began sewing up the lacerations on Sherlock's arms, trying to ignore the knowledge that Holmes had done this to himself, and properly attended to the rest. He checked his friend over but found nothing else than what could be seen directly, aside from a couple of old bruises that were probably from fights in the ring, and the scarred shoulder which was still tense and most likely, sore.
Mrs Hudson entered again.
"Mrs Hudson, please could you prepare some soup for Holmes?"
"Certainly. Doctor, your wife is here to see you." she stepped aside and he saw Mary standing there, concern written on her face.
"John, what's wrong?" she asked, moving towards them.
"Mary - you didn't need to come..." John said, glad she hadn't come when Holmes was high.
"I know. I wanted to. Is it serious?" she stepped in to a position where she could see him better. "What happened?"
"It's not as bad as it looks." John said awkwardly, feeling like he was betraying his friend. "He... took something he shouldn't have."
"What happened to his arms?"
"Whatever he took caused him to hallucinate insects under his skin."
Mary stared at Holmes for a while, shock and sorrow in her eyes.
"I'm not sure exactly what it was... Cocaine, I think. It isn't like him to be so irresponsible with it though...perhaps he took it in combination with something else. Alcohol perhaps." John looked around the flat and wandered over to the chemistry equipment, thinking out loud as he went. "It looks like he has been experimenting with Cocaine... heating it and combining it with ... baking powder?"
"What does that mean, exactly?" Mary asked, totally unfamiliar with Chemistry.
"I'm not sure..." Watson pondered, wishing he had the profound knowledge of chemistry and physics that Holmes did. "But whatever he's invented, it would appear to manifest as a much more dangerous form of Cocaine." he looked at his wife, tension lining his face. She placed a hand on his arm supportively.
"Watson..." came the weak call from Sherlock.
Mary thoughtfully excused herself to help Mrs Hudson.
"Watson - you needn't stay. It's all right."
"It's extremely far from all right."
"Had no idea it would be so...potent..."
"You can't just experiment with narcotics Holmes, Cocaine is dangerous enough on its own."
"Please...return to your marital bliss..."
"I can't do that. I can't leave until I know for sure you won't try to get some more." Watson sighed. "Why do you want me to leave anyway?"
"Why would you want to stay?" Sherlock countered, in his typically exasperating way.
"Because I'm your friend, Holmes." Watson stated explicitly.
"Watson, I have deduced from your long absence that you have found more enjoyable ways to spend your time than in my company."
"That isn't true." Watson felt shame colour his face, even though he knew the drug was still playing havoc with his friends thoughts and feelings. "I didn't come because of this Holmes...because of your irresponsible recklessness in the face of danger!" Watson realised the truth for himself, looking at the weakened state of Holmes. "You make a living out of chasing death, Holmes, and the truth is that I can't bear to follow you around, just to watch you die in front of me"
John sat down, deflated. The anger left him as he turned a critical eye inward. "I saw you, launch yourself off that ledge and over the falls. I saw your heart and breathing stop on that train. I heard you being tortured. I went to your funeral for gods sake!" he looked away, clamping down on any tears that threatened. "I was so happy to see you alive again but...losing you once was bad enough. To lose you twice would be..." he smiled sadly and shook his head in despair. "But after all we've been through together, how could you possibly think that I don't like you?"
Holmes looked away. "Well... you never said." he said stubbornly, though Watson could see he felt stupid now the question had been posed out loud.
"You were my best man, Holmes, doesn't that tell you anything? Can't you deduce anything from that? Or from the times I've risked my life for you? You are the closest thing to a brother I have. "
There was another awkward pause. The doctor cleared his throat.
"I'm sorry for not coming to see you. It was a despicably selfish thing to do. If it's hard seeing you hurt in front of me, it would be worse still to know you were hurt and I was absent."
There was a knock on the door and Watson retrieved the soup from Mrs Hudson with thanks.
"Try and eat some of this. You don't have to eat it all." he said, helping Holmes. To the doctor's approval, Holmes managed almost half the soup, and a glass of water, before practically passing out to sleep.
There was another reason Watson had been putting off calling...he knew Mary was right about that. They were going to start a family, and he knew that getting Holmes to see this as a good thing was going to be a struggle. Watson was afraid to see his good news turned to something hurtful and bitter between them...and had no idea how he was going to bring it up. But he would.
Finally, Watson fell asleep in the chair next to Holmes.


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Women Men Adore: Every man dreams of 'the perfect woman', and most women want their partner to adore them. But what exactly are those perfect traits that make men adore a woman, and how can you make a man fall in love with you while still being yourself? Is it possible to become the woman men adore and want to love and to be with?
The stereotypical model-type, or busty glamour puss will always turn a man's head, but these exterior features are not necessarily what a man sees as the subject of his undying adoration.
Here are some of the common attributes present in the kinds of woman that men adore.
• Men are highly sensitive to a woman who seems special, or different to other women they've dated. Women know their own best qualities, so once you get a sense of the kind of man he is, show him what makes you unique, and how you think you can be his perfect match.
• Men are much more interested in a woman who is a little 'hard to get'. This means not always being available when he wants, and allowing him to think about you and miss you being around
• Men adore women who possess a high degree of self respect, and who also demand respect from them
• Men adore a woman who is self confident and completely comfortable in her own skin.
• Men are naturally protective, so while self confidence is essential, it's also vital that you let him know you are attracted to his strength and that he makes you feel safe. Asking for his help is a huge turn-on
• Men are attracted to a woman with a sense of humor, but that doesn't mean a woman who tells bawdy jokes. Men are drawn to playful flirting and suggestive, witty repartee
• Men are turned on by a woman who shows a high level of intelligence, but never one who commandeers a conversation or corrects him in public
• Men will always be attracted to a woman who is well groomed, dresses smartly and gives the impression that she loves the way she looks, and showing a little skin doesn't hurt, to initially grab his attention
• Men love to impress their friends, so he'll love it when he introduces you to his buddies and you can make a striking impression on them right from the start
• Men really love a woman who can cook up a storm
• Men adore a woman who enjoys making love as much as he does, so once your relationship is established, and he's already made the first move in bed, it's important to keep the sparks flying by initiating the action regularly
• Men need fidelity and commitment to the relationship.
It goes without saying that not all relationships are built to last, but with the incorporation and renewal of just a few of these characteristics, you'll be the subject of your man's undying adoration in a long and happy relationship. If you want to capture his heart and make him give you the world, if you want men to adore you, respect and love you, then you need to read this How to Capture a Man's Heart and Make Him Give You all You Want
[youtube_sc url="http://www.youtube.com/watch?v=7AjNyaoH41Y"]
Download The Woman Men Adore and Never Leaves


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Statue memorializing young accident victim remains missing
Three-and-a-half-year-old Jack Larson couldn't go to sleep without his favorite stuffed elephant "Alfie." Now Larson's grandparents, Donna and Jim Larson are losing sleep over a replica statue of the same elephant.
The three-foot tall, 200-pound woodcarving that memorialized Jack after his death in May of 2009 was stolen from the Larson's pole barn in Merrifield earlier this week. Though several days have passed since the theft was reported the Larsons have received no information about who might have took the memorial.
"That stuffed elephant was the one thing that was close to him and this statue is equally as close to us," said Donna Larson. "It was a memorial for Jack and wouldn't have any meaning to anyone else.
"It's really just a very hurtful thing that someone would take it."
Displayed at the entrance to the Larson's home on Sorenson Lake Road during the summer months, Larson said the statue was stored in the barn during the winter. The statue was the only thing taken from the barn, place behind four-wheelers and power tools, Larson said.
"We haven't found that anything else was taken and are still not sure how someone got in there," Larson said.
But the biggest question behind the theft remains why?
"That sculpture was quite an emotional thing for me as well as the family," said Pat Scrimshaw, who created the woodcarving for the Larson's and said he will make a new one if the original is not found. "A lot of sanding and a lot of work was put in to it to make it special and really memorialize Jack in that sculpture.
"I hope they find it because sure I could make a new one, but I could never duplicate what was created. I just don't understand why someone would take that away from them and away from Jack."
Jack Larson was the son of Kory and Becky Larson of rural Brainerd. The boy was killed on County Road 3 after being struck by a minivan driven by Sherman Frederick of Crosslake. Before hitting the child, the minivan had passed several stopped vehicles on the right-hand side shoulder of the road.
Frederick was found guilty of criminal vehicular homicide and a lesser and included charge of careless driving in 2011.
"We'd like to know why (someone took it) and if they just bring it back we won't press charges," said Larson. "We just really want it back."
Anyone with information about the woodcarving is asked to call the Crow Wing County Sheriff's Office at 829-4749.
JESSI PIERCE may be reached at 855-5859 or firstname.lastname@example.com. Follow her on Twitter at www.twitter.com/jessi_pierce (@jessi_pierce).


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|"Mark Miller (JIRA)" <j...@apache.org>
|[jira] [Commented] (SOLR-3706) Ship setup to log with log4j.
|Thu, 21 Mar 2013 20:11:16 GMT
[ https://issues.apache.org/jira/browse/SOLR-3706?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=13609398#comment-13609398 ] Mark Miller commented on SOLR-3706: ----------------------------------- Just some general sanity review would be good. I tried running tests in eclipse as well as making sure test fails with ant test still logged. Someone might have comments on the logging format, I got it from the wiki or something. I also tested run-example and it logs. I updated the README to mention you might want to turn off the console logging and that we use log4j by default. If someone can review, I'll commit it. > Ship setup to log with log4j. > ----------------------------- > > Key: SOLR-3706 > URL: https://issues.apache.org/jira/browse/SOLR-3706 > Project: Solr > Issue Type: Improvement > Reporter: Mark Miller > Assignee: Mark Miller > Priority: Minor > Fix For: 4.3, 5.0 > > Attachments: SOLR-3706.patch, SOLR-3706-solr-log4j.patch, SOLR-3706-solr-log4j.patch > > > Currently we default to java util logging and it's terrible in my opinion. > *It's simple built in logger is a 2 line logger. > *You have to jump through hoops to use your own custom formatter with jetty - either putting your class in the start.jar or other pain in the butt solutions. > *It can't roll files by date out of the box. > I'm sure there are more issues, but those are the ones annoying me now. We should switch to log4j - it's much nicer and it's easy to get a nice single line format and roll by date, etc. > If someone wants to use JUL they still can - but at least users could start with something decent. -- This message is automatically generated by JIRA. If you think it was sent incorrectly, please contact your JIRA administrators For more information on JIRA, see: http://www.atlassian.com/software/jira --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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Backcountry.com Classic Goat T-Shirt - Short-Sleeve - Men's - $20.95
Good news, the Backcountry.com Men's Classic Goat T-Shirt loves rafting, kayaking, backpacking, hiking, trail running, travel, and sometimes sky diving. Smooth, soft cotton and lightweight synthetic material means that this shirt dries in a flash and feels so comfortable you'll swear you're on vacation whenever you're wearing it. - $20.95


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Sandwiched between Europe's epic Ryder Cup wins at Celtic Manor and Medinah was a victory arguably as improbable and indubitably more important. It was delivered by Europe's women in Ireland, a triumph against the American foe which also doubled as a blood transfusion for the Solheim Cup.
Europe had not won since 2003. The contest was failing as a spectacle under the weight of American dominance. If it were to have a future it needed Europe to land a punch. They did more than that. They fashioned the ultimate climax, retrieving a losing position with a knockout blow on an extraordinary afternoon at Killeen Castle.
Europe climbed off the canvas to come home 15-13. Suzann Pettersen did the Ian Poulter thing, rattling off three straight birdies to beat Michelle Wie one-up. And her fellow Swede Caroline Hedwall, two down with two to play and a captain's pick this time, did the… yes, she did the Ian Poulter thing, winning the final two holes to claim a half against Ryann O'Toole. Oh, and the weather was worse than Celtic Manor, but never had it mattered less.
That rousing finish saw ratings at the American broadcaster, the Golf Channel, soar by 35 per cent on the numbers generated four years earlier when the contest last took place in Europe. A cable company can do business on numbers like that, and with the spiked interest came the commitment to continue with the show and end talk of scrapping the two-team format in favour of a round-robin event to include a third international team, allowing for the powerful factions from Asia and Australia.
Two years on and Poulter was being button-holed on the putting green at Oak Hill after his final round in the US PGA Championship last weekend to wish his European sisters well in a cheeky address. "Go get 'em, girls," said Poults.
Europe have neither won in the United States nor retained the trophy so a historic double first is the requirement in Colorado over the next three days if the Cup is to return home with them.
Five members of the team that won so dramatically in Ireland make this selection alongside six rookies, the youngest of whom, Charley Hull, was not born when the inaugural match took place in 1990.
At 17, Hull is the youngest participant ever on either side, and with five runners-up spots on the Ladies European Tour already in her debut season, she brings a fearsome competitive spirit to the piece.
Pettersen, who alongside Scotland's Catriona Matthew is making her seventh appearance, welcomes the infusion of young blood. "I think it's healthy for us to have new players coming up," Pettersen said. "I don't think it's a disadvantage to have a lot of Solheim Cup rookies. They're all out there, and they're fearless and have nothing to lose.
"I think it's much better to have that kind of player rather than the experienced ones who put a lot of pressure on themselves and have everything to prove to the rest of the world that they deserved this spot on the team."
The Americans start as heavy favourites. In rankings and experience they are packing a heap of muscle. When Wie makes it only as a captain's pick, it gives some indication of the depth of the American talent. Wie seems to have been at the heart of the US game forever, yet she is still only 23. Like many a juvenile starlet co-opted by the system she lost her way through adolescence but is starting to reassert herself on her own terms.
The outstanding American of this vintage is the world No 2 Stacy Lewis, who made up four shots on the back nine at St Andrews to win the Ricoh Women's British Open a fortnight ago. She has formidable support in fellow twentysomethings Morgan Pressel, who led going into the final day before finishing in a tie for fourth, and Paula Creamer, plus veteran Cristie Kerr.
The American team also includes four rookies, two of whom, Lexi Thompson, 18, and Jessica Korda, 20, are in the Hull category of vaulting ambition.
Central to Europe's chances are the contributions of Pettersen and Matthew, tied fourth and 11th respectively at St Andrews. Youth is a fine attribute but at some point the babes might just need mothering.
Solheim Cup: How it works
The Solheim Cup follows the same template as the Ryder Cup, featuring two days of fourballs (in which each player plays their own ball) and foursomes (players hit alternate shots using one ball).
Each team selects four pairs per format and the home side decides the order, one format in the morning, the other in the afternoon. Each match is worth one point to the winners or 0.5 each if the match is tied, or halved. The contest ends with 12 singles matches on the third day.
As holders after winning 15-13 in Ireland in 2011, Europe need 14 points to retain the trophy or 14.5 to win it for the first time in America. The United States lead 8-4 in matches overall.
Kevin Garside
- More about:
- Colorado
- Golf
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- Ryder Cup
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- St Andrews Golf Course
- The Open Championship (golf)


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Pam and I set up a booth at a new furniture/vintage store in Columbia, Tennessee the first of this month. I've been posting pictures and information on our Facebook page, but haven't had a chance to put pictures on the blog. You can find our Facebook page HERE
These aren't the best pictures. (Unfortunately I locked my keys and purse in the trunk of my car as I was getting my camera out to take these pictures and was a bit distracted while taking these :( I also have the kind of car that can't be unlocked by a lock service, and isn't easily towed. Three days and a special order key later, I finally retrieved my keys and drove my car home.)
Pam did an awesome job on this buffet/dresser. It is painted in Annie Sloan inside and outside.
I love the bistro chairs. These look so much like the ones used on Fixer Upper.
If you are in the Nashville/Franklin/Spring Hill/Columbia area please consider visiting The Calico Cow. It is located in a bright green building with lots of parking, at 100 Nashville Highway in Columbia. It is a new store and all the vendors have moved in lots of goodies. I'm eager to go back and check out the new stuff myself. If you are local to Nashville, Murfreesboro or Franklin, we can arrange for a pick-up. Just email us if you see something you are interested in.
Thanks for stopping by!


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Wally Backman Thinks He's Being Blackballed From The MLB By Mets GM Sandy Alderson
I only have one main rule when it comes to baseball blogging. When you blog about Wally Backman, no matter what the context of the story, that's the video you use. There's no excuse for not having it in there.
Now, we've gone through some pretty entertaining Wally Backman stories and videos over the years, but we've never had a conspiracy theory before. This is some groundbreaking shit, so let's get right into it. Backman, who is managing in the Mexican League now, after most recently managing the Mets' Triple-A affiliate, the Las Vegas 51s, is alleging that Mets general manager Sandy Alderson is blackballing him from Major League Baseball.
Backman will be leaving for south of the border in about a month, convinced he's been blackballed by GM Sandy Alderson. It's an explosive charge, and not one that Backman makes lightly. But after a long winter of being turned down by other clubs, despite a willingness to start at the minor leagues' lowest levels, Backman believes it's his former boss who's responsible. Actually, Backman says it's not a guess or a hunch. He claims a friend in the commissioner's office has tipped him off that Alderson is working against him.
"There's been a bad roadblock, and I know where it's coming from," Backman said by telephone from his home in central Oregon. "In the last phone call I had with Sandy [in September] he said, 'I will do anything I can to help you.' But he is not an honest man. People are telling me, 'Sandy has it in for you. You're being blackballed.'"
"I've talked to several teams, and every one of them has said, 'You're overqualified.' How can you be overqualified when you're trying to win? No one is overqualified unless there's something else going on."
The rest of the story goes on to talk about how Alderson declined to comment, and cites sources close to him that said it's not in his character to be "vindictive" or some shit like that. I don't know the guy, so I can't call bullshit here, but I see some holes in Backman's logic. First thing that stands out to me is that Backman is talking about how badly he wants to win. As a minor league manager? That's not your job. Your job is to follow the specific orders given to you by the organization as a means to develop the players you're managing to their liking.
According to the story, the Mets asked Backman to resign or else he'd be fired, so he did. Backman was confused as to why the organization would want to let him go in the first place, but apparently the 57-year-old skipper's fatal flaw was bypassing direct orders from the organization in order to win as many games as possible. Is that grounds for firing? Yup. But, being blackballed from the whole league? Either he's not being blackballed at all, and teams just don't want to hire him because they know he doesn't listen to direct orders (likely), or there's more to the story that we don't know, which is causing every other organization in the league to pass on him (plausible).
Either way, I cannot wait for the videos that are going to come out now that Wally Backman is managing in Mexico. The language barrier is content waiting to happen.
PS — Google Translate tells me that "Vamos a coger una cerveza" is "Let's go get a beer" in Spanish.


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Surely, you have gone to a fair or concert where people were lining up in front of food concession trailers. These trailers can certainly be a hit in these events and it makes you wonder, can you run a business like that and make tons of money?
The good news is that anyone can buy concession trailers but the challenging part is actually running the business. But do be warned, the best people to run this business are those who like working outdoors and during events. If you're someone who likes to stay cozied up in a restaurant, running a mobile kitchen is definitely not for you.
Buying the Mobile Kitchen
- Design, Size and Layout. Before anything else, you must come up with a business plan. You must know what type of food you want to sell because concession trailers have to be customized according to your food service. Apart from the design, the size of your concession trailer will also depend on the type of food you plan to serve. You have to consider the amount of equipment, serving stations and the amount of space that the vendor can work with. Moreover, the layout of food concession trailers should be included in your business plan too.
- Equipment. Considering that the concession trailers are where vendors do the storing, cooking, preparing and selling, you better make sure that you are fully equipped. Start by planning out the equipment you really need, maybe a freezer, fridge, deep fryer, meat smoker or stove top burner? If you can pick dual or multi-purpose equipment, that's better as you can save space inside the trailer.
- Brand New or Used. Choosing between brand new and used concession trailers will ultimately boil down to your budget or how much you can borrow from your creditor. If you can't really spend much, mobile kitchen dealers can offer you used concession trailers that are actually reconditioned already.
- Warranty
Whether you are shopping for used or new food concession trailers, the dealer should provide you a nationwide warranty. Do keep in mind that you'll be taking your mobile kitchen to different places and often, far away from home. If something breaks, you need to be able to get it fixed right away without paying extra.
The success of your mobile food business will depend on your business plan, marketing efforts and how delicious your food really is. Also, the entire look of your concession trailer will add an enticing factor to customers too.
Five Diamond Trailers make the highest quality concession trailers that will fit your mobile food vending needs. Visit http://www.fivediamondtrailers.com for more information.


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US firm Paul Hastings Janofsky & Walker has boosted its Paris projects team with a four-lawyer raid on Ashurst.
Paul Hastings has made Ashurst senior lawyers Pascal Cuche and Marc Lordonnois partners in its Paris office, and hired two associates. Their practice encompasses public law and infrastructure deals, and focuses particularly on public private partnerships (PPP). Clients include contractors, public authorities, banks and investment funds.
John Hawkins, global head of Paul Hastings' projects team, said: "The burgeoning PPP sector in France and Europe requires lawyers with a great depth of infrastructure finance expertise. We continue to make strategic acquisitions of leading practitioners to our projects practice in the US, Asia and Europe."
Paul Hastings hopes that the new team will increase the amount of work coming in from emerging markets as French contractors look abroad for new opportunities.
Jonathan Simpson, European projects chief, said: "It will immediately boost our cross-border PPP practice, particularly in Central and Eastern Europe but also in the US and Asia where French contractors are becoming increasingly more active."
A spokesperson for Ashurst said: "It's been quite amicable. Two of them have gone and been promoted to partnership at Paul Hastings. It is is a good career move for them and we wish them good luck for the future."


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Kre-O Customizer Hound and Predaking Attack Set Listings
Saturday, October 5th, 2013 11:34AM CDTCategory: Toy News
Posted by: LOST Cybertronian Views: 22,732
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Posted by Noideaforaname on October 5th, 2013 @ 12:54pm CDT
Assuming of course Hound doesn't end up being Movieverse Hound.
Predaking I'd guess is the Prime version? We already have the combiner, and the Autobot Base set seems to imply a push for more Prime-style Kreons (even if it's kinda late). Again, about time. Not sure why Ripclaw (who didn't really even look like Ripclaw) got to be the face of the Beast Hunters line.
The product dimensions imply it's a large build set. I'd say you would build a large Predaking, but Kre-O seems to be getting away from those.