text:
"We will work as constructive opposition in the Lok Sabha and will not create a situation where even question hour was disrupted as during the previous tenure," he said.
"Congress has decided to give constructive support. We will cooperate with the government and will function as a watchdog," Thomas, who was elected to the Lok Sabha for a fifth term from Ernakulam constituency told reporters at a Meet-The-Press Programme organised by the Press Club here. Crores of rupees are being spent on the swearing-in of the Prime Minister designate, he said.
"After A B Vajpayaee's swearing-in, crores are being spent now on swearing-in of Narendra Modi," Thomas said. Pointing out that UPA I and II had done good work like bringing in RTI, Food security Act, he said "some mistakes have happened. Victory and defeat is common in an election". To another question, he said "we have got leaders like Sonia Gandhi and Rahul Gandhi, and Priyanka Vadra should take an active role in the Congress".


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Guest reviews
Overall rating
Recent reviews
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Located off of I-75, the budget-friendly Red Roof Inn Forsyth offers comfortable accommodations at an affordable price. The Central Georgia Convention Complex is walking distance of the hotel. Rose Theater and many eating opportunities can be found in downtown Forsyth about a mile away. Monroe County Hospital and the Georgia Public Safety Training Center are within a few miles. Just a short drive away from Macon Georgia, and the many attractions found there including the Shoppes at River Crossing. All guestrooms at the Red Roof Inn Forsyth include free WiFi, flat screen TV, microwave & refrigerator, hair dryer, iron & ironing board, and in-room coffee. Full kitchenette is offered in select guest rooms. Continental breakfast is offered daily in the lobby (6am-9am) including waffles, danish, cereals and juice. Free coffee & tea available in the lobby. Coin laundry is available for guest use. Enjoy the outdoor seasonal pool (open May – September, weather permitting). One well behaved family pet is welcome per guest room.

subset: commoncrawl


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Posted by Azucar Bakery on 19th Aug 2014
As many of you know, Azucar Bakery was nominated to Best Wedding Cakes on Denver A-List.
We finished 3rd on 2011. We finished 2nd on 2013. And we hope to get 1st place this year with your support! Voting is now closed and will update you as soon as we find out the results in about a week or two.
Many of you also left your comments about Azucar Bakery on Denver's A-list and we appreciate all your great feedback!


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|Message view
|« Date » · « Thread »
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|"Chris Douglas (JIRA)" <j...@apache.org>
|[jira] Commented: (HADOOP-3628) Add a lifecycle interface for Hadoop components: namenodes, job clients, etc.
|Sat, 02 Aug 2008 00:03:33 GMT
[ https://issues.apache.org/jira/browse/HADOOP-3628?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12619167#action_12619167 ] Chris Douglas commented on HADOOP-3628: --------------------------------------- Should ping() catch {{Throwable}} from innerPing? Throwing an IOE with whatever came out of innerPing as its cause would widen the range of errors it can report, most of which are probably not I/O related. > Add a lifecycle interface for Hadoop components: namenodes, job clients, etc. > ----------------------------------------------------------------------------- > > Key: HADOOP-3628 > URL: https://issues.apache.org/jira/browse/HADOOP-3628 > Project: Hadoop Core > Issue Type: Improvement > Components: dfs, mapred > Affects Versions: 0.19.0 > Reporter: Steve Loughran > Assignee: Steve Loughran > Attachments: AbstractHadoopComponent.java, hadoop-3628.patch, hadoop-3628.patch, hadoop-3628.patch, hadoop-3628.patch, hadoop-3628.patch, hadoop-3628.patch > > > I'd like to propose we have a standard interface for hadoop components, the things that get started or stopped when you bring up a namenode. currently, some of these classes have a stop() or shutdown() method, with no standard name/interface, but no way of seeing if they are live, checking their health of shutting them down reliably. Indeed, there is a tendency for the spawned threads to not want to die; to require the entire process to be killed to stop the workers. > Having a standard interface would make it easier for > * management tools to manage the different things > * monitoring the state of things > * subclassing > The latter is interesting as right now TaskTracker and JobTracker start up threads in their constructor; that's very dangerous as subclasses may have their methods called before they are full initialised. Adding this interface would be the right time to clean up the startup process so that subclassing is less risky. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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text:
Increase newsletter open rate with artificial intelligence.
Kevin William David
@kwdinc · Community @Siftery. No 1 Hunter on PH🥇
SendPulse Artificial Intelligence makes e-mail marketing better. SendPulse creates a behavior user profile for each subscriber based on their communication preference, timezone, content, layout, product purchases and many other unique data points. The user profile is than used by the AI platform to not just create the best experience for each user, but to … See more
Bogdan Su
@bogdan_su · Founder at MobalyticsHQ.com
Looks like a great tool. Btw, do you use any email enrichment service (i.e. clearbit.com) for personalization or all the data is collected by you?
Manana Samuseva
@manana_samuseva · CEO/Founder ILIFTTV
This is crazy, cool idea! I was literally discussing this exact concept with my team a few weeks ago. So happy to see someone made it. Actually founder convinced me to try SendPulse and to start sending out newsletters. Simple interface & amazing crawler. Before you start using the API Platform, I have a few questions, I really like AI and personaliza… See more
Avinash D'Souza
@avinashdsouza · VP, Marketing @ Deck Apps
Sounds like a winner if they get it right! *fingers crossed* What behaviour patterns within user groups is the AI trained to recognize? Does the AI make content/engagement suggestions based on these patterns? Even as a classic ESP solution, looks pretty sweet as an offering compared to what's out there...it's definitely the only product I've seen that bund… See more
Mark Savchuk
Seems to be useful :) I've encountered these problems in my work. You need to talk to one of your clients, you seem to send them emails when they should be online, but they never reply. Because they are not always "checking their email". It is a problem indeed, thanks for thinking about it :)


text:
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- 744478
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text:
'King and I' gets royal treatment in new Broadway revival
By Patricia Reaney
NEW YORK (Reuters) - A revival of the Rodgers and Hammerstein 1951 musical "The King and I" is getting the royal treatment on Broadway with a 29-piece orchestra and huge cast in a production critics say is breathtaking and beautiful.
The show that opened on Thursday night at the Vivian Beaumont Theater tells the story of the Welsh widow, Anna Leonowens, who travels to Bangkok in the 1860s to become a teacher to the King of Siam's children.
Yul Brynner and Deborah Kerr immortalized the roles in the 1956 film, which won five Oscars, including best actor for the Russian-born Brynner, who took home a Tony award for his portrayal of King Mongkut in the original Broadway show.
In the new stage production, multiple Tony nominee Kelli O'Hara plays the feisty Anna with Japanese actor Ken Watanabe as the monarch.
"You can't overstate how stunningly beautiful, how achingly well sung this new revival of 'The King and I, is" said the New York Post newspaper.
Although written decades ago, USA Today said the musical about different cultures and love was still relevant.
"The 'King and I' still has much to tell us about our differences and shared interests - about all the beautiful and new things we can learn from each other, day to day," it added.
The show reunites O'Hara with director Bartlett Sher, who worked together on "South Pacific," in a performance the trade magazine Variety described as "ravishing." Continued...


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text:
Morning Sea
Watercolor on paper on cradled wooden panel, 24x18x1-5/8 inches, Taos, NM, 2016.
Twilight Sea
Blue on Blue
35mm photograph, 20"x32", Lunada Bay, 2016.
Indigo Wash
35mm photograph, Lunada Bay, 2016.
Summer Sky
35mm photograph, Redondo Beach, California, 2014.
Glistening Curl
Good Morning Wave
Morning Curl
Dancing Sea
Oil on 100% rag paper, 28" x 42.75"'; Berkeley, CA, 2016.
Oil on 100% rag paper, 28.5"x43", Berkeley, CA, 2016.
For months, almost every day I have driven along the top of the hills, catching views across the San Francisco Bay when the road curves west. Every day is different with colors and contrast changing with the flow of sun, fog, clouds, wind and rain.
Clouds, Sea, Rain
Oil on canvas, 30"x36"; Berkeley, CA, 2016.
Spray (Barcelona Study I)
Oil on stretched canvas, 22.8 x 22.8 x 1 inches, Spain, 2015.
Spray (Barcelona Study II)
Oil on canvas, 22.8 x 20 inches, Spain, 2015.
94-04-207 In Mare
94-04-207 In Mare
Monotype, 15.3x15.3 on 30x22 100% rag paper.
Digital photo.
18x24, 30x40, 37x50; or 36x48 or 45x60 on aluminum.
L'Onda (Wave)
As a the wave approaches shore, the water becomes increasingly shallow. The bottom reflects more light up through the wave, and the water become brighter as it dances to shore.
Contact Gloria Delson Contemporary Arts, Los Angeles, CA.
6239. 25x34 each, watercolor and metallic gouache on Kozo rice paper
$5,800. Original triptych beautifully framed, floating on linen, 31.25"x110".
93-04-190 Breezy Day
The wind kicks up the surf all around off the shore of Kailua.
93-04-190 Breezy Day
Monotype, 23.5x15.5 on 100% rag paper.
93-04-191 Kailua
On the windward side of Oahu, the ocean dances on the reef off Kailua.
93-04-191 Kailua
Monotype, 23.5x15.5 on 100% rag paper.
Surf 23
Film originated photo.
16x16 up to 30x30 on paper; and up to 40x40 on aluminum.
Surfin' the Soup
Surfing Santa Cruz, California
35mm digital photograph.
Yellow Surfboard
Surfing Santa Cruz, California on a yellow surfboard.
35mm digital photograph.
Surfer, Down the Line
35mm digital photograph; Ocean Beach, 2014.
Down the Line
Surfing down the line, Santa Cruz, California.
35mm digital photograph.
Surfer, Stand Up, Sit Down
Surfer, Santa Cruz
35mm digital photograph, Santa Cruz, CA, 2015
Surf 24
Film originated photo.
Print available on paper, aluminum; or
Giclee on watercolor paper.
Oceans I: Descend
40x30, Oil on canvas, California, 2011. SOLD.
Available as giclée on watercolor paper or canvas.
Oceans I: Ascend
40x30, Oil on canvas, California, 2011. SOLD.
Available as giclée on watercolor paper or canvas.
All Images Copyright Norlynne Coar
Summersky8617Lunada Baycloudsoceanhorizon
From Nature


text:
A concept waiting to happen: a Gabriel covers album.
The concept? A song-exchange project twixt prominent figures who will reciprocate in due course. The music? It's orchestral, pianistic, drumless, slow, formal and, being Gabriel, sung with enough lockjawed grainy drama to generate that peculiar Gabriel effect, English soulfulness. An obvious point of comparison is Joni Mitchell's brace of orchestral covers albums. The songs? Bowie, Elbow, Bon Iver, Paul Simon, obviously Randy Newman... But no Moonglows.
- More about:
- Joni Mitchell
- Peter Gabriel
- Progressive Rock


text:
Perwyn (i)Mature
Two and a half centuries ago Louen, former Emperor of Vharktüm, fled from the High Council of the Old Ones when the pact was broken and settled in the ancient land of his people.
The new Kingdom of Louena had finally begun to settle down after the remnants of Louen's people were curbed into one nation, the Barbarrans were defeated and forced to flee into the Crown of Ice, the Eruvian conclave was absolved and entered the realm and trade routes were finally established with Elegeia, Tundrahk and
"My Liege, the dead must have their rest!" Lord Aedrin Ridling stepped out from the crowd of petitioners and assembled noblemen in the Grand Hall, out from amidst the columns adorned with numerous friezes.
"And they shall." Lady Layla said, who had already been standing at the base of the steps that led to the throne. "Once I find mine, I will cease the blockade when my son is returned to me, High Sage, no sooner."
Perwyn watched, from the left of where the King sat, with his sword in his hands, the tip on the ground. The throne itself was a wondrous piece of marble, carved from the floor itself, but it made no sound as the King shifted uncomfortably.
"I find it hard to see why the crown would permit such a decisive and, dare I say, destructive course of action." Lord Ridling called out, his long, dark, oiled back hair with his neatly trimmed beard was a stark contrast from Lady Layla, who both were of a height, though neither particularly tall.
Perwyn couldn't see the King's face, but he could imagine it wasn't best pleased from the flush creeping down his neck.
"The Eruvians ought have considered that when they took the boy." Your boy, mother. A band of cloth had been wrapped around her tightly tied, greying hair. She cut an intimidating figure despite being older, shorter and more crabbed than most of the room.
"The dead have done nothing deserving of your ire, surely a simple pass can be warranted—"
"—oh truly, they did nothing deserving, well then what a fool I have been. By all means, let everybody through." She retorted, her long fingers whipping towards him.
The King shifted again, unable to get comfortable it seemed as some of the guards looked at each other.
"I was merely referring to a search and pass tactic, it's simple politics."
"Fine. So I let the coffins through, then I have merchants asking, then mercenaries, book keepers, bakers, until the North is laughing at a crumbling wall. No the blockade stands firm, do not presume to lecture me on misguided notions of simple politics, you oaf. No ship shall pass the Pendant so long as my demands go unseen, and by Hetharn's Law on Retaliation, I have done nothing illegal."
King Leo Tawniton sat forwards and the two moved to listen.
"Have no fear, Lady Layla, on good council, I have begun communication with the Eruvians. Once I hear reasonable terms we shall consent to end this debacle." Some small cheers arose from noblemen until Lady Layla's voice rang clearly above them all.
"Then I have every cause for fear, knowing who sits your council." The scathing remark was met with howls and angry cries as she looked to the High Sage. He's playing you, he wanted you to sound unreasonable and now the nobles who have stakes about the realm will hate you.
The King leaned back and whispered to Perwyn. "I knew I should have sent you with young Courts and my nephew. Darn it all, how do I appease this woman." He cursed softly.


text:
Disclaimer: Don't own it, don't sue me.
Note: Ha ha! Got an update up within the week! I rock! Just kidding. I hope you enjoy this chapter; it was really easy to write, for some reason. Please review! They mean so much to me…
The rest of the visit flew by for Andean and Hanna. They continued to do work in the village, and provided many of the poor with supplies and even found jobs for a few that were willing to work hard. Mistral had had a good deal of progress in his healing, and Hanna had been successful in procuring a job for him with the local cobbler. He was very neat with his hands, and making shoes seemed to suit him. She herself ordered a pair of boots and a pair of fine black slippers from Tudessa's newest artisan. He had been thrilled with the order.
Hanna had noticed with increasing worry, though, that both her mother and Andean were becoming melancholy and much quieter than their wont. Even though she thought she knew the causes for both of their lethargy, she was still concerned. Andean knew that he must face his decision about his mate when he returned, and Maryla was sure to be worried about the time, fast approaching, when her daughter would leave and she would be left alone again. Hanna felt powerless to help these two dear ones…what could she say? What could she do?
Just ask them straight out, Caedmon advised when she asked for his thoughts on the matter. You can get a lot further with a person with honesty than with diplomacy. Beating around the bush doesn't solve anything. You'll have to be careful with Andean, though…elves are not accustomed to sharing their innermost feelings with others, especially not humans.
The day before they were due to leave, Hanna went looking for Andean, and found him on her own old mountain precipice. She came up behind him, silently she thought, but the elf still heard her. "Do you know what this place is, Hanna-elda?" he asked, without a greeting beforehand.
Hanna was surprised by his breech of etiquette, but said, "Yes. This is where I found Caedmon's egg. I imagine it to be an old breeding place of the dragons."
"You were correct." Andean sighed deeply. "Long ago, dragons must have come here, and then later, a dragon Rider. That egg was left here on purpose, although to what purpose, I can't imagine. You'd think that the Rider would want it to stay with the eggs, where it would be safe. Not out here, on the edge of the wild. I imagine we'll never know." His voice dropped again, and he returned to staring moodily out on the landscape.
Hesitantly, cautiously, Hanna walked up to her friend and mentor. She placed a slender hand on Andean's arm and said, "Andean. It's time."
Startled, Andean looked down into Hanna's emerald eyes and replied, "Time for what?"
"It's time for you to make a decision. We leave this place tomorrow, and must return to Ilirea. Have you made a decision? Do you know who you will choose? I don't ask you to share with me your thoughts if you don't wish to, but my friendship with you compels me to offer my support."
Andean observed Hanna wryly. "So you know about that whole mess then. I wondered. Who told you? Silme?"
"Yes, eventually. But I learned of it from another before that. Please, Andean," Hanna begged. "I want to help you. I may be friends with Silme, but I also know that you have huge pressure on you."
Andean ran a distracted hand through his hair. "Oh, Hanna….I don't know what to do! Aelwyn I promised my hand years ago….but to Silme I have promised my heart. I can never offer it to Aelwyn, for it is no longer mine. Everything I am belongs to Silme…except my word. That Aelwyn holds. I must be an honorable man, and to break my vow to her would bring her intense suffering, if not shame."
Hanna was quiet for a minute. "I cannot pretend to understand elven politics, Andean. I can barely understand your tongue," she said dryly, not even realizing that the ancient language was pouring out of her mouth as fluidly as her own mother tongue. "But…can you bear to bring the suffering of a broken heart to Silme? Can you bring that kind of pain to Endellion, he who shares you fully? Anything that you will suffer, he suffers with you.
"Aelwyn made her choice when she was very young. It could be that she would eventually regret her choice, and then you would be trapped forever. Oh, Andean!" she said passionately. "Take it from one who has had experience in the matter. Even dishonor is better than a marriage where love does not dwell. Do not put yourself into that living death, or you will kill both yourself and thy dragon."
She took a deep breath, and continued in a slightly stern voice. "If you think you can love Aelwyn, then you should honor your vow to her. But if you believe that Silme is the mate of your lifetime, then your old vow to Aelwyn has already been broken anyway, whether you meant it or not. It's time to make the choice."
Andean was silent for a long time. Indeed, the stars were coming out by the time he spoke to Hanna, who was standing, silent and resolute, by his side. "You are right, Hanna Svit-Kona. I have already broken my vow to Aelwyn. She must understand…that I cannot give what I have not. Silme has my heart, and to offer that to Aelwyn in marriage would be stealing. I choose…." Andean swallowed. "I choose Silme, the starlight who has entered my life and has made it all the clearer." Without another word, he turned and left the mountainside, still too emotional to say anything else.
Caedmon flew up a little later and found Hanna, curled up and asleep beneath her old tree. He hummed, and gently wrapped his body around her without waking her up. I am proud of you, little one, Caedmon said in his deep, growling voice. Even though his Rider slept, she smiled in her sleep.
Early the next morning, the morning they were due to leave, Hanna woke up. Her heart was heavy even before she could realize why. Little one, you will miss your mother. But do you not think that she must learn to live on her own? Caedmon asked gently.
I don't know, Caedmon. I fear what she will do if loneliness strikes. She was dying when we came, surely you realize that. If I lose her…I will have lost everything except you. How can I leave her to her pain?
I don't have an answer. Hanna, accustomed to Caedmon always knowing what to do, sighed heavily and leapt on his back so that he could fly them back down to the farm.
Andean was already in the front yard, putting saddlebags on Endellion. Hanna smiled when she saw the difference in the Elf. His step was light and his eyes shone brightly. He looked as if he could hardly way to get back to Ilirea. "Eager to see a young lady, are we?" Hanna teased. Andean actually blushed, which she hadn't known elves could do, and continued with his work.
Hanna found her mother in the kitchen. Maryla was resolutely packing food into leather wraps, and it wasn't until Hanna came closer that she realized that Maryla face was wet with tears. "Oh, Mother!" Hanna flung herself into her mother's arms, even there despairing of their painful thinness. "I wouldn't leave unless I had to. You know that, right?"
Maryla brushed a kiss across her daughter's forehead. "Of course, my Hanna. I know that. I wish that I could be stronger and let you leave with a light heart, knowing that I was all right. Don't worry about me, love. I'll make it just fine. It's just a matter of learning how to live again…"
Hanna sobbed, and clutched her mother tighter. Her mind whirled and swirled, and suddenly a thought came to mind. Casting herself out of her mother's arms, she ran back outside to Andean. "Andean!" She called, but then came close enough to whisper. "Were we not told that if we had need, we could contact our masters?"
Andean looked startled. "You told me that your master said that all you would have to do was reach out with your mind, Hanna. You do not need to scry-just ask for him and he will answer." He turned away to give Hanna some privacy.
Her face blanked and she said hesitantly, Master?
Vrael's voice came into her head at once. I am here, Hanna. Is everything well?
Yes, Ebrithil. Andean and I are making our preparations to return to Ilirea. I am sorry to disturb you…
Do not be sorry. I am glad you did. What can I help you with?
My mother…she is sad. She looks much better than she did, but I fear what she shall do when she is alone again. Please, master, I need your advice.
There was a long silence, and Hanna feared that she had somehow angered her master. I do not know if this is the answer, Hanna…but there is room enough in Ilirea for one human mother.
Hanna caught her breath in her throat, and Andean turned, concerned. Oh, Ebrithil! Do you mean it? Can I bring my mother home with me?
Master Adon and I rather expected it would come to that. We have only one stipulation-your mother must not be able to see where she is going. That was she can never reveal the location of Ilirea.
How do we do this, Master?
Speak with Andean. He knows what to do. I will see you when you return. He severed the connection, and Hanna whirled around to face Andean, shock and joy shining in her eyes.
Andean smiled. "I take it we shall be heavy one more person on the return trip, then?"
"So you knew?"
"Of course. Master Adon provided me with an elixir that will make your mother sleep deeply until we return to Ilirea. Then she will awake, well rested and completely unaware of the location of our city."
"I must go and ask her if she wishes to come…thank you, Andean!" Hanna darted into the house, screeching "Mother! Mother! Such wonderful news!"
Maryla came out of the kitchen, wiping her hands. "Slow down, Hanna! Whatever is it?"
"Mother," said Hanna solemnly, even though she could barely restrain her enthusiasm, "do you want to come back with me? Leave Tudessa and go live with the elves?"
Maryla staggered for a moment, and clutched at a table for support. Hanna rushed over to her mother and helped her into a chair. "Mother? Are you all right?" she asked fearfully.
"Yes….yes, of course. I'm fine. I'm just so shocked…and happy. Oh, Hanna! Is it true, that I can escape this life and begin anew with my daughter?"
Hanna nodded vigorously, her chocolate hair bouncing on her shoulders. "Yes, Mother! My master only had one stipulation-that you be kept from seeing the way back to Ilirea. We have a potion that will make you sleep until we get back, and then you'll wake up, fully yourself again. Will you agree to that, Mother?"
Maryla looked doubtful, but then shook herself and stood up strong. "I don't like the idea of being put to sleep, but I'll face it in order to leave this place and be with you. But…" she faltered, "how shall I ever be ready in time? The house…the fields…my things. You and Andean are leaving any minute!"
"What do you really need from here, Mother? Just get your most essential things, the elves will provide the rest. As for the house…Andean and I can close it up. It shouldn't take that long. Please, Mother. Can we do it?"
"Yes," Maryla said. She turned to run back to her bedroom. "I'll be ready in a minute!"
With Andean's capable help, the two apprentices soon had the furniture covered, valuables locked away, and the shutters all closed securely. No thief would break into that stone house that had stood for so long. Andean even gathered all of the food in the kitchen and flew with it to the village, where he gave it to Kenly to distribute to the poor. He also left instructions for the fields to be tended, and the profits of the harvest to be given to the poor of Tudessa. In a little over three hours, everything was attended to.
Maryla came proudly out of the house where she had been imprisoned for so very long, clutching a few parcels and dressed in dark traveling clothes, her white hair hidden under a blue scarf. "I'm ready," she said breathlessly. "I'm sure I've never done anything like this before in my life, acting so rashly."
"Believe me, Mother," said Hanna happily, "You won't be sorry." Taking the key to the house from her mother's hand, she turned to the door, and with a firm twist of her wrist, locked it securely. She hung Maryla's packages carefully from Caedmon's saddle while Andean pulled a small flask from Endellion's.
"Please, madam," he said gently, "just drink a small drought from this, and you'll wake up in no time at our home."
Maryla took the flask in trembling hands and lifted it to her lips. Seconds later, she was sinking to the ground, already in a deep sleep. Andean caught her easily in his arms, and carefully bound her to Endellion's saddle. "Endellion is older and better able to carry the extra weight," he told Hanna. "Do not fear. I will not allow your mother to come to harm."
"I know it," Hanna replied. She climbed onto Caedmon's back and said to her green friend, Let us leave this place behind us, Caedmon. All of it. I'm ready to move on.
I'm glad, Hanna. It's time. With a great leap, the two dragons jumped into the sky, moving joyfully through the air.


text:
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- The Kennedy Center expansion, designed by Steven Holl architects, will be constructed south of the existing facility, and will include rehearsal, classroom and public access space. ()


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Texas Tech Researchers Discover Antibiotics in Store Bought Shrimp [VIDEO]
Researchers at Texas Tech University found evidence of contamination after they tested some samples of farm-raised shrimp that came from abroad. Within the testing, the researchers discovered evidence of antibiotics and one of those antibiotics is a suspected dangerous human carcinogen. The shrimp was purchased from grocery store right here in the good ole USA.


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UPDATE 2-Insurer Catlin benefits from low London rate exposure
* Net premiums up 6.5 pct to $2.04 bln
* Average weighted premiums down 3.2 pct
* Pretax profit up 118 pct to $318 mln
* Shares up more than 5 pct (Adds COO, analyst quotes; share reaction; details)
By Richa Naidu
LONDON, Aug 8 (Reuters) - Bermuda-based Catlin Group said first-half profit more than doubled as the insurer's geographical spread shielded it from weak pricing that has dogged its British rivals during the period.
Catlin's London-listed shares shot up more than 5 percent on Friday, making it the biggest FTSE-250 percentage gainer.
Rates of insurance against potential disasters have been either stagnant or in decline mainly due to increased competition and fewer large catastrophe claims over the past year.
Catlin said its exposure to "more resilient" pricing in the United States, Europe and Asia had made it less vulnerable to sinking rates in London and Bermuda, where wholesale and catastrophe reinsurance lines dominate the market. Continued...


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Botox temporarily relaxes the muscles by blocking the chemicals which contract them. Botox is widely used to soften wrinkles.
Botox is a toxin produced by the bacterium Botulinum. Botox temporarily relaxes the muscles by blocking the chemicals which contract them.
The ideal age to start Botox is when you start to become affected by your wrinkles.
Your doctor or dermatologist will advice you to avoid alcohol and anti-inflammatory medication (such as ibuprofen and asprin) upto two weeks from the Botox treatment. This is sugested to reduce skin bruising.
It takes a few days for the Botox injection to give results. The effect of the Botox injection lasts approximately to a period of three months.
Botox injections are given by trained medical professionals even if it is only for the sake of cosmetic purposes.
Do botox injections hurt?
Botox injections are given by smallest available needle, called Gucci needles. Most people don't feel pain, but may experience slight discomfort.
How many times can you get Botox injection?
There is no restriction to the number of times you can have a Botox injection. However, it must be ensured that the time in between two injections is a good enough time of nearly 4 months.
Can you make out if some has done Botox?
Yes. The impact of Botox is quite visible at times. Sometimes, it leads to a youthful look. Otherwise, it may lead to droopy eyelids.
When should you consider cosmetic surgery over Botox?
Botox is not a permanent solution and it does not give the same result as face lift surgery. In cases, where reshaping and removal of facial tissues are required, cosmetic surgery has to be considered.
How much does Botox cost?
A Botox injection can cost upto Rs. 5000 per injection. It depends on the number of units used


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Great place to stay for business or pleasure. Clean, spacious rooms and very friendly staff. No dislikes.
The location was perfect for walking around and enjoying Downtown Nashville. The maid had to be asked to clean the room after two days.
The only thing i liked was the location!! The hotel is well over priced with what you get.There was no bottled water in the room and having to pay for breakfasts on top of the price of the room is outrageous, making it a very expensive trip.
the luxe the bath was to little
Location! Clean Underwhelming for high cost Cafe hours are not convenient Valet very expensive and then we had to wait over 20 min
Close to everything but far away from the fast pace of the entertainment area.
Location, location, location. Lobby was unique, having been an old 1920's bank building. Room was sparsely furnished. Small room, typical of Marriott Courtyard. Lounge chair needed a reading lamp over it. Lousy lighting in the bath area.
Staff was helpful and friendly. Hotel was clean and inviting. No continental breakfast.
Nice room great facility Nothing


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Food and drink for groups
Great value Meal Deal Vouchers are available to groups and tour operators at the Tower of London. Different options can be selected:
Lunch: £12.95
Main course dish from our hot counter, a hot or cold drink and a cake or desert pot
Light Lunch: £9.95
Seasonal soup or a sandwich, hot or cold drink and a cake or dessert pot
Cream Tea: £5.50
Traditional Cream tea includes a delicious homemade scone with English strawberry jam, Cornish clotted cream or a slice of homemade cake and your choice of tea or coffee.
Meal Deal Vouchers are available to groups of minimum 15 people.
To book, contact:
Three easy steps to redeem a Meal Deal:
- Contact the Catering Manager at the venue of your choice to register for the voucher scheme and to receive your vouchers.
- Overprint or stamp your vouchers with your company name/logo and select the appropriate meal option before distributing to your group.
- Notify the Catering Manager 72 hours prior to the group's visit. Following the visit, you will receive an invoice based on the number of vouchers collected.


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Quick police work is being credited with the arrest of a 17-year-old accused of robbing the Rite Aid store on Union Street in Bangor Monday afternoon.
It all started at around 4:15pm, when the suspect apparently had a finger under his coat, implying he had a weapon. Workers in the store gave the robber an undisclosed amount of cash.
A customer reportedly called 911, police say that call came in at 4:20.
Officers converged on the area as the suspect was leaving the store, and he was arrested about two minutes later.
The teenager, who's from the Bangor area, is being held at the youth correctional facility in Charleston this morning.


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New Braunfels Herald Zeitung (Newspaper) - March 19, 1993, New Braunfels, Texas mama reserved COKE PRODUCTS 12 PK 12 OZ CANS, FRITOS ALL FLAVORS $1.99 SIZE 12 PK. COORS. MILLER & BUD ' PREMIUM BEER 12 OZ CANS I PRICES OOOD THRU MVti RUDAT, MAUCH IS. 1993 HERALD-ZEITUNG 3 Alamo Area Council * t honored for reports The Alamo Area Council of Government! was recently awarded a Certificate of Achievement for Excellence in Financial Reporting by the Government Finance Officers Association of the United States and Canada. The certificate recognises the highest standards for preparation or state and local government financial report, and was awarded to the AACOGfor its comprehensive annual financial report for the fiscal year ended Dec. SI, 1991. The AA(X)G, comprised of Atascosa, Bandera, Bexar, Comal, FHO, Gillespie, Guadalupe, Kames, Kendall, Knr, Medina and Wilson Counties, is a voluntary associe* tion of 96 local governments that addresses regional concern! through planning, information and coordination activities iii areas ranging from health and human settees to economic devoir opment, Job training and housing; In order to be awarded a ear} tiflcate, a government unit must publish an easily readable and efficiently organised comprehend sive annual financial report with contents that oonform to program standards. Hie reports must satisfy accounting principals and legal requirements. FOK I ( AS I Today** forecast calla for tonight, becoming cloudy, low* In the upper 40s and 50a. Extknoki) FORIX ASITonight Cloudy Chance of rain: 20% Lows In the 50s Highs In the 70sSaturday Cloudy Chance of rain: 20% Lows in the 40s Highs in the 60sFriday Cloudy Chance of rain: 30% Lows In the 60s Highs in the 70sSunday ciouoy Chance of rain: 20% Lows in the 40s Highs in the 60s Water Watch Comal River................................................................ 462 de (same) Edwards Aquifer..............................................................628.94 feet (up .01) Canyon Lake Inflow................................................................362 eft (up 27) Canyon Lake Outflow............................................................£80 eft (same) Lake level......................................... 906.74 feat (up .06) Information for Water Watch is provided daily by officials with New Braunfels UtHiti— and tbs U.S. Army Corps of Englnasn st Canyon Lake. previous puzzle solvso □□qqq ranraa □□am □buhr awm dana annao raammwanriR BRD UHR?] □□□RR □□□RR UBHHRLin RQRraRm unnriR □HORR □□HQRBHuJCi HOR REHDRR OHR □RORRHQRB □□ROR RnnaR mohcirk hwwbhtin HonnR □□□aw drama hod RHRmaoRRR nmaoB R RODO mWRRR M ORRR MUaUR $•19*93 ® 199$ Untied Feature Syndicate 40 French peaks 41 — and crafts 43 Cattle breed 45 Fuel dispenser 47 Matures 49 Antelopes 51 Inward 53 Mention 54 Extraordinary parson: slang 55 Eye layer SS Enter 57 Doss of medicine 55 Jazz singing 59 Sailors 61 Anger S3 — the lins MARCH SPECIALS "Savings ol the Green" a.nounlookslgnlng Local authors Rosmsrte Leissner Gregory, lift, and Myra La# Adams Golf, right do nato a copy of their book, Klndarmaakanball Past and Present: 150 Yaars of Heritage to librarian Vicky Hooker. A book signing party WIK ba bald 1-5 p.m. Saturday, March 20 at Sasla Parish Houss.Sex ed test laws to give parents control Associated Press AUSTIN — Conservative lawmakers ars touting legislation regarding sax ideation and sUndardistd tasts in schools that thsy contend would strengthen parental rights. Legislation by Rep. Warren Chisum, D-Pampa, and Sen. Jane Nelson, R-Flower Mound, would require that if local school districts taaeh sax education, substantially more attention be given to abstinence from tex than any other activity. Their legislation would also require that parents be notified of the contents of the sex education program and that they opt to put their children into the courts. Schools would not be required to teach sex education, but if they did, they would have to follow the •tate rules. A separate bill unveiled Thursday by Rep. Jim Horn, R-Denton, would allow parents to look at a state-mandated standardised test after it has been given, but before it has been graded. Horn ■aid parents should have the right to know the test contain. Under the bill, parents could withhold their child's test from the grading process if they could prove to their school board that any questions on the test ere psychological rather than academic in nature. Parents and others currently cannot look at the tests for security reasons, according to the Texas Education Agency. TODAY'S CROSSWORD PUZZLE Saturday, March 20 • The New Braunfels Area Quilt Guild will hold its monthly meeting at 9:30 a.m. at the New Braunfels Christian Church, Loop 337. Lynn Lewis Young from Great Expectations Quilt Shop in Houston will present a program "Fabrics and Color for Quilts." More information is available at 625-1166, or 6252820. Sunday, March 21 • The retired Eagles Activity Club will meet 2-6 p.m. Sunday, March 21 at Eagles Hall. Members are asked to bring sandwiches, but those having birthdays or adversaries are asked to bring cake or cookies for the afters noon. • Spring Branch Lodge 127 — Hermann Sons will meet for a brief business meeting after which ell will go to Spring Brand) Bowling Club for an afternoon of bowling. Members bring sandwiches, drips, dips and birthday desserts. Members are asked to bring sandwiches, drips, dips and birthday desserts. Monday, March 22 • The Canyon Lake Retired Teachers Association will moot at 9:30 a.m. at the Methodist Church. Lucille Biegel will apeak on legislative matters affecting teachers. Tuesday, March 23 • The Colonial Dames XVII Century will meet March 23 at the Education Center, 430 W. Mill St Parking is in the rear of the building. Member* should take the street level entrance and the •levator on the right to the second floor. Hie program "Colonial Clergy" will be presented by Mary Beth Lobo. • The Book Review Chib will meet from IO a.m. to 11:30 a.m., with coffee at 9:30 a.m. at the Senior Citiaen Center at 666 Landaff. Barron Schlameus will review Roomer's Texas (1845-1847) by Ferdinand Roomer. Coot for members is Hoper year, for guests cost is a |2 dilation. • Th# Comal County Democ rats will meet at 7 p.m. March 23 at Ryan's. Kathleen Krueger, wife of Senator Bob Krueger, will be the guest speaker. Gloria Sasser, 820-1515, or Cheryl Scott, 629-0441 may be contacted for more information. Thursday, March 25 • Friends for Rivers will meet to discuss Alture projects at 7 p.m. March 25 at Victoria Bank and Trust. Plans include a 10K fundraiser. Representatives from Wast Management will present a program on recycling. More information is available at 629-2066. • The New Braunfels Multiple Sclerosis Support Group will meet at noon, March 25 at Finkel's Restaurant McKatie Goar will speak on stress. • The Downtown Rotary club meets every Thursday at noon at Krause's Restaurant Monday, March 29 • The New Braunfels Branch of the American Association of University Women will meet Mon day, March 29, at 7:30 pm in the VictQria Bank Building. The speaker for the evening will be Sherry Tomko, art therapist for Hospice, who will speak about the role of art theraply in the Hospice program. Readers in the community are reminded that the annual book sale will be April 3 and donations of used books are desired. Persons having books to contribute may call Agnee Lehmann, 625-5391, for pickup. •The 29th annual Spring Art Show sponsored by the New Braunfels Art League will be May 29-30, Memorial Day weekend, in the Civic Center, 380 South Seguin. Fees are 155 for non-members and $20 for NBAL members for an 8-by-10 exhibit space. Exhibitors may show original work only; nudes, kits, commercial exhibits and items purchased for resole ere not allowed. Artist end craftsmen who have not displayed with the Ait League before should send several pictures (perferred) or slides representative of their work for screen- Red Purse Week New Braunfels Business and Professional Women's Club members are holding their purses in recognition of "Red Puree Week," March 14-20. This week is set aside to bring emphasis to the fact that the salaries of women ere "in the red" as compared to their male counterparts. Photo by John Huseth. Activities ing purposes and a self-addressed stamped envelope for their return. Entry deadline is April 15 with acceptance by April 25; late entries will be taken on standby. An entry form may be requested by calling Pat Deltz at 210/629-4607 or the Arts Center Gallery at 210/629-8022. Written inquiries should be addressed to the New Braunfels Art League, P.O. Box 310326, New Braunfels. CRUISE SALE "24OM" Fares Call for details. 629-2215 133 Landa Street ACR088 1 Jolly -6 Criticize* 10 Chinese: prel. 14 Occupied 15 Departure 16 By love! 17 Brought into harmony 18 Astronomer's instrument 20 Curvy letter 21 Reformer Jacob — 23 Trash 24 Made to go 25 — Alto, CA 26 Dredging bucket 30 Do fishing. In a way 34 Rest 35 Helps 37 Gambler's cube 38 "Limp as ># 39 Evaluator 41 An opera 42 Pert of forest soil 43 Editor'! word 44 Coolant! 46 Look fixedly 48 Too early 50 Burl - 52 Girl 53 Rebate document 56 Show lurpriee 57 CA time 60 Brainchild 62 NY city 64 High-schooier 65 Dry 66 Tooth 67 Memorable periods 68 Cozy rooms 69 Animal skins DOWN 1 Ceremony 2 Burden 3 Arma 4 Ethnic suffix 5 Amend! 6 Smell end trim 7 Hatchett, e.g. 6 Nothing 9 Headstone 10 Zone 11 "-- Rhythm" 12 Neck pert 13 Polish river 19 River sediments 22 Be Innate 24 Urban haza 25 Ballet move 26 Packs tightly 27 Dormouse 26 Armadillo 29 Sooner or — 31 Farewell 32 Lese narrow 33 Rental document 36 Plays STUMPED? SET— --- 1-SOMM-iaii ext, code 800 a tis par wawls f ;
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text:
Belle 4 piece Comforter Set
Add to wishlist
Belle is the essence of frilly and pretty. The layered ruffles create luxurious dimension as they cascade over the bed. The brushed poly fabrication is so soft to the hand you'll just want to surround yourself with this comforter. Part of the Belle Collection.
- 4-pc set includes: One comforter, one bed skirt, two pillow shams
- 250 GSM Comforter
- California King Comforter: 96"H x 110"W, Bed Skirt: 84"H x 72"W x 14.5" drop, Shams: 20"H x 36"W
- King Comforter: 96"H x 110"W, Bed Skirt: 80"H x 78"W x 14.5" drop, Shams: 20"H x 36"W
- Queen Comforter: 96"H x 92"W, Bed Skirt: 80"H x 60"W x 14.5" drop, Shams: 20"H x 26"W
- Fabric Content: 100% Polyester
- Fill Content: 100% Polyester
- Dry clean
*Ships from Dayton, NJ.


text:
Aliante [CD]
- Artist: Come Le Foglie
- Release Date: 03/22/2013
Best Buy is dedicated to always offering the best value to our customers. We will match the price, at the time of purchase, on a Price Match Guarantee product if you find the same item at a lower price at a Designated Major Online Retailer or at a local retail competitor's store.Here's how:
- If you find a qualifying lower price online, call 1-888-BEST BUY and direct a customer service agent to the web site with the lower price, or when visiting a Best Buy store, one of our employees will assist you.
- On qualifying products, Best Buy will then verify the current price to complete the price match.
Exclusions apply including, but not limited to, Competitors' service prices, special daily or hourly sales, and items for sale Thanksgiving Day through the Monday after Thanksgiving. See the list of Designated Major Online Retailers and full details.
- Come Le Foglie
- Mago Del Tempo (Vola E Va)
- L' Aliante
- Tj
- Cara Milano
- Realtà
- Gloria E Il Pilota
- Birds
- Isola Di Hydra
- Incoscienza
- Amalfi
- Via Lodovico Il Morro
- L' Emigrato
- Dove Sei Felicità
- Gli Ombrelli Di Volterra
- Mia Principessa (Finale)


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Welcome to Bedford Hills Golf Club
Our scenic Bedford Hills Golf Club gives the golfer a feeling that is not found anywhere else near Temperance and Toledo, Ohio. Whether you are seeking to improve your game, or simply indulge in a day of Temperance golf, our course is recommended for you. Our picturesque golf course will allow you to focus on your golf game and leave the distractions of life behind. You will be able to test your skills with our long fairways, multiple water hazards and tactically placed sand traps. Most people who play our course really enjoy it so much, they book their next tee time after their round of golf.
When you come play Bedford Hills Golf Club, you will thoroughly value our professionally kept facilities and 27 hole courses.
You can purchase all your basic supplies in our golf shop.or stop in our snack bar which includes a fullly stock bar, hot dogs, brats, sandwiches, weekly specials and more!
If you have been wanting to perfect a part of your golf technique, come practice on our driving range.. Our eager staff has one main goal; and that is to make sure you have the best day of golf as possible.
For Tee Times or More Information Please Call (734)-854-4653


text: Moulin Rouge - Rehearsal Tracks CD Moulin Rouge - Rehearsal Tracks CD Marching Band(Diamonds Are a Girl's Best Friend; Nature Boy; One Day I'll Fly Away; Rhythm of the Night). Marching Band Rehearsal Tracks. CD only. Published by Hal Leonard (HL.3745068). Usually leaves our warehouse: Within 3 to 5 business days More info Add to Cart { "catalogRefId":"19537708", "productId":"prod19537708", "quantity":"1" }


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Names and ShamesMature
"Sire?" Deacon said.
"I've told you not to call me that Deacon" Dawn growled he stood up and put his mug on the worktop
"Dawn" Deacon corrected "what's wrong?"
"What's always wrong?" Dawn sighed.
"Gabriel" Sylver frowned "did you listen to a word I said?" Dawn nodded.
"I told him I would back off" Dawn said quietly "but it's not easy"
"Out of curiosity" Jay said looking up at Dawn who nodded. "Where's he gone to vent?"
"No idea" Sylver said "why?"
"Because there's a pool room with big metal shutters that close over the water it would be ideal."
Why didn't you say?" Sylver smiled "he's probably terrorizing half of Holehallow by now" he pulled the door open.
"Dawn" Deacon said "come on" he pulled the daemon towards the door.
"Deacon I don't really feel like it" Dawn said tiredly. Sylver poked his head back around the door.
"You might want to feel like it" Dawn could hear shouting now.
"For god's sake" he growled following Deacon out of the door.
Gabriel walked out into the corridor and stopped looking around then he sniffed and headed away from the atrium. Rounding a corner he saw a daemon standing alone by the wall the thin daemon watched with cold eyes as Gabriel passed him.
Gabriel quickly walked around the next corner almost bumping into another daemon. His hand moved around his waist gripping the hilt of one of the short swords at his waist and he carried on walking.
Gabriel sped up as he heard footsteps behind him he growled rounding another corner and realizing it was a dead end. He turned to see three daemons walking down the corridor towards him.
"Someone wants to see you" one of them grinned.
"I wonder who?" Gabriel said his voice calm he walked straight towards them and the one who'd spoken put a hand on the vampyres chest to stop him. "You really want to move" Gabriel growled.
"Do I?" the daemon smiled Gabriel gripped the daemons wrist and twisted his arm making the daemon howl the other two backed away.
"Cowards" Gabriel snarled as he released the daemon he strode past them and back the way he'd come. He stormed around the corner just as one of the doors behind him opened.
Dawn and the others ran down the corridor, the electric lights flared as they passed.
"I do hope that's not Gabriel doing that" Deacon said.
"Me too" Dawn growled Sylver kept his mouth shut as they jogged along.
Gabriel hit the ground landing on his front and skidding a little way on the dusty floor.
"You embarrassed me" Balthazar hissed
"You embarrassed yourself" Gabriel snarled standing up and brushing himself down. Balthazar growled as doors all down the corridor began to open the daemons inside wondering what was happening. "Well?" Gabriel frowned Balthazar hadn't moved again. "are you going to do anything?" Gabriel waited a moment before he sniggered and turned walking away. Behind him Balthazar growled and moved quickly down the corridor behind Gabriel.
"how dare you walk away from me?" he thundered.
Gabriel didn't turn the lights on the wall flared brightly buzzing angrily as Gabriel felt the massive daemon close in behind him.


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Career Services counsellors use a holistic approach with different models of career decision-making and systematic career counselling. A process that works for many people involves eight stages as described below. You and your counsellor will decide whether you need counsellor assistance for all the stages and which activities will best meet your needs. It is important to note that time is an important factor in the process and the more you put into it, the more you can expect to get out of it.
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text: Home Gallery Video Cancer Patients Aid Association Chanting Lighter Cancer Patients Aid Association: Chanting Lighter Think twice before lighting up. Published on Feb 29, 2012 Editor's Pick To encourage people to quit smoking, Ogilvy & Mather India thought of an innovative way to talk to customers at the very moment they decide to light up. In India, cigarettes are often sold loose at little newsstand-like set ups on the street. These little shops often have lighters so people can light up as and when they want. O&M refitted the lighters so every time someone used them, a Hindu chant that is usually heard when someone dies would play. Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateFeb 29, 2012Agency:Ogilvy & Mather MumbaiClient:Cancer Patients Aid Association CategoryExhibitStunt Latest Creativity News on Ad Age Reynolds-Maclean Joins Biscuit, Contagious Signs Anderson Watch the Newest Ads on TV From Ford, FedEx, Target and More Sean Smith Joins Solve, Anomaly London Adds Creative Directors Related work Vodafone: Self-Defense Umbrellas Ogilvy & Mather Mumbai Lifebuoy: Hand Pump Ogilvy & Mather Mumbai Google India: Pledge to Vote with Mr. Shyam Negi Ogilvy & Mather Mumbai


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Chrysler's Lenders Make New Offer on Debt
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This is why. (Really.)
For my brothers uttering contemptuous oaths to their stagnant interrogators, to resist a pen for their ploughshares, waiting one more day after one more day after one more day that the capwick would close upon our oppressors flame, snuffing out their infants and leaving their dogs to dine in the market . Those who would not lay down at St. Andrew's Keep will watch their widows lay amongst the worms and trophies of their bastard sons weeping ochre iron within their sullied loins.
That after the day is ours, the leather will snap like switches of willow; scars creeping open like glistening ladybugs and the long wail of pleads for yield will crest as a new moon's Waltz.


text:
by Jerry Spinelli
For as long as Palmer LaRue can remember, he has dreaded the day he will turn ten and must take his place beside the other ten-year-old boys in town and become a wringer, a tradition passed down from father to son. From Newbery Medal winner Jerry Spinelli comes a gripping tale of how one boy learns how to overcome his fears.
Newbery Award Winner
- Ages
- 11, 12, 13
- Interest Level
- Grades 6 - 8
- Publisher
- Tandem Library
About the Author
Jerry Spinelli Jerry Spinelli won the Newbery Medal for Maniac Magee, the sixth of his more than fifteen acclaimed books for young readers. Growing up, he wanted to be a shortstop in the majors long before it occurred to him to be a writer. Crash came out of his desire to include the beloved PennRelays of his home state of Pennsylvania in a book. And, of course, to show the world a little bit about athletes and what makes some of them tick.
The Reading Toolkit
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It's about that time again — from fashion things and beauty obsessions to the restaurants I can't stop thinking about (and everything in-between) let's take a look at my March mood board (AKA this month's vibes).
What Why Where: Shearling & Shine
When you're well into winter (and now that we have a foot of snow on the ground, it looks like it's not going away anytime soon), trying to put an outfit together that's warm and stylish can get pretty daunting. But when you have a strong outerwear game (the most important game in Chicago) it makes that task a little easier. I like to think I'm an avid coat collector and when it comes to this shearling and shine, it might just be my new favorite.
CCF Loves: 143 Tees
There's always that one thing we're on the hunt for the "perfect" version of — it might be a black dress, ankle boots or a solid piece of outerwear (especially for us Chicagoans!) — but I'm sure the one we all have in common is one that the latest CCF Loves can solve. Looking for the perfect tee? 143 Tees has got your back (quite literally!) So let's meet the owners — Jenna Saltzman and Lyndsey Ager.
To The Rescue
To say I'm obsessed with dogs is an understatement. I'm the person who has to stop and pet every single dog (even though I have two of my own). You can find something dog-related in every corner of my apartment (including my closet). And I'm a total sucker for a rescue pup. Which brings me to today's post…
February Vibes
For being such a short month, there's still a lot to pack into February — Valentine's Day, Fashion
Week Month, Grammys, Oscars…and if you didn't think that was enough, here's everything else you need to know about this February!


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Bridge organisations
There are 10 regional Bridge organisations funded by Arts Council England to use their experience and expertise to connect children and young people, schools and communities with art and culture.
Bridge organisations will continue to support schools to achieve their Artsmark award through the delivery of Artsmark Development Days. These events will explain your journey ahead, support your high level planning for the arts in your school and allow you to network with other schools in your area.
In addition, each Bridge organisation creates its own offer to support the development of Artsmark within their region. Contact details for your local Bridge organisation are listed below:
020 7608 2132
01603 877750
East/ South East
01708 892824
South East
023 8033 2491
Kristianne Drake, Artsmark and Arts Award Manager
email@example.com / email@example.com
East Midlands
The Mighty Creatives
0116 2616 834
West Midlands
0121 446 3204
Helen Frost, Programme Developer, Artsmark and Arts Award
South West
08458 621288
North East
N.B. Artsmark is being delivered by The Forge working in partnership with Culture Bridge North East.
The Forge: 01207 284515
North West
01772 827001
Yorkshire and the Humber
0113 322 3050
* Festival Bridge covers Norfolk, Suffolk, Cambridgeshire and Peterborough.
** The Royal Opera House Bridge covers Essex, Hertfordshire, Bedfordshire, the unitary authority of Medway and the North Kent districts of Dartford, Gravesham and Swale.


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25% off ALL apparel. That's right. All. Of. It. Use STUFFTOWEAR
and now the rains weep o're his hall, and not a soul to hear.
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Knight-Errant Artorias
I'll probably not follow a continuous storyline throughout this piece of writing. The Dark Souls universe is not insignificant in size and spans multiple disconnected timeframes, so I'll likely pick up on separate storylines that take my fancy as things turn up. For my first story arc though, we'll be focusing on my so-far favourite character, Artorias.
The stench of the Great Swamp filled his nostrils and stuck to the insides of his armour. It was hot. The water ran to his waist and with each step a little more slime oozed into his boots. The bugs snapped and zipped in the trees amid the calls of birds and other beasts. Incessant chirruping filled the air with echoes like those from the walls of a cave. It made the space claustrophobic. Still Artorias trudged on. He wore full armour, save for his helmet, which hung from a strap on his waist. Though it would not have troubled him to wear it despite the sickening humidity, he preferred the wider field of vision afforded by travelling with his head bare; there were undead here. Though rare, it was said that the curse of the undead was spreading, and that a fully hollowed enemy was ferocious and paid no heed to pain or injury. Other twisted and fallen things were banished to the swamp too; those who practised the primal art of pyromancy, demons escaped from the ruins of Izalith and creatures warped by the touch of the Bed of Chaos. Artorias was wary of such foes. He had faith in his battered and rusty armour, he had faith in his towering greatshield, but he did not come here to fight undead monsters and demons. The greatsword slung across his back was not for them. It was for the creature who had fought Lord Gwyn and lived, a vast monster, a survivor of the war, and one of the last of its kind, still said to have one of Gwyn's sunlight spears embedded in its flesh. Thus, in Anor Londo it was named Ansgar, God-spear. In this country, however, it was called another name: King Dragon Akaash, vast as the sky.
Artorias trudged through the swamp. His granite black eyes cut a straight path ahead. He ran a gauntleted palm along the hilt of his sword. Once again, he thought. Once again, we will be hunting dragons.


text:
The celebration was conducted on Saturday, Dec 18 in Delhi. The reopened Saran Rani Backliwal Musical Instruments Gallery is packed with rare 17th century instruments. It has a large collection of musical instruments, both folk and classical, and many of them were from the 17th and 18th Centuries.
Amjad Ali Khan streamed various ragas to herald the reopening. He told that it was an honour to perform in the National Museum. Also, Amjad Ali Khan requested authorities to invite young scholars to research on classical musical instruments, especially on sitar, sarangi, and santoor and publish the research works.
The launch of travelling exhibition 'Heritage Him-sagar' also brightened the evening. This exhibition is scheduled to cover the entire stretch of the country from Kashmir to Kanyakumari on road, giving a glimpse of the country''s golden past, rare artefacts and richness of culture.
Presiding over the function, Jawhar Sircar, Secretary, Ministry of Culture, said the government was taking several initiatives to preserve the cultural heritage of the country.
OneIndia News


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text:
Williamsburg Bridge Decay Is Worse Than Feared
By KIRK JOHNSON
Published: April 14, 1988
The Williamsburg Bridge, eerily silent and nearly empty yesterday after being abruptly and completely closed for safety reasons on Tuesday night, is far more corroded in its steel roadbed structure than engineers had previously feared.
City and state officials yesterday attributed the damage to years of poor maintenance, incomplete inspections and ignorance about how quickly steel can rot away under the harsh conditions above the East River.
They said that the 85-year-old suspension bridge would be closed for at least three weeks for continued examination, and that under the worst-case scenario -signficant further deterioration in places that are difficult to repair - it may be months before the bridge reopens, if it reopens at all.
''There's no question about it, this is bridge crisis,'' said the city's Transportation Commissioner, Ross Sandler. ''It's been a long time coming, but now it's here and we have to respond.''
It was also a crisis for the 240,000 commuters - including motorists and subway riders - who normally use the bridge each day and who had to find alternate routes into and out of Manhattan.
Only pedestrians and bicycles are allowed on the bridge now, with the subways halted and cars, buses and trucks diverted elsewhere. Traffic, Traffic, Traffic
City officials did not have figures on which alternative routes bore the brunt of the crush yesterday, but noted that there was no easy route. The traffic nightmare was compounded by a truck accident on the Brooklyn Bridge, a bus accident on the Manhattan Bridge and a fatal car-bus crash on the Long Island Expressway near the Brooklyn-Queens Expressway. [ Page B2. ] Many of the other 2,024 bridges in New York City, while not in as bad a shape as the Williamsburg, are also troubled. About 50 percent are listed as ''structurally deficient,'' according to state transportation officials. [ Page B2. ] The Williamsburg Bridge, which was already partly closed and has long been scheduled for rebuilding or replacement, has not been given an ''in depth'' inspection since 1979, despite repeated reports of rust and decay, according to a spokeswoman for the state's Department of Transportation.
The spokeswoman, Phyllis Hirschberg, said that although a private company had inspected the bridge on a ''follow-up'' basis from late 1984 into 1985, that inspection concentrated on the suspension cable support system, which was then believed to be the weakest aspect.
The 1985 study, by a Manhattan engineering consulting concern, Ammann & Whitney, found only three ''flagged'' conditions in the roadbed beams. A flagged condition means that a section is a potential threat to public safety. Ms. Hirschberg said all three of those areas had been repaired.
City transportation officials said yesterday that with less than half of the bridge inspection complete, engineers had found 30 ''severely'' corroded beams - some as much as 90 percent eaten away - in the eight traffic lanes and two subway track roadbeds of the bridge, which spans the East River between the Lower East Side of Manhattan and the Williamsburg section of Brooklyn. They said a phenomenon known as corrosion cell activity, which greatly speeds the normal process of oxidation or rusting, could explain why the 1984 study did not uncover the problems found in the current inspection.
''I'm not looking for scapegoats,'' Mayor Koch said in a news conference held under the shadow of the bridge on Delancey Street in Manhattan. Like a Car Battery
A civil engineer who sits on the Transportation Department advisory committee that is considering the bridge's future said yesterday that corrosion cell activity can occur when a metal surface remains continually wet, particularly with dirty or salty water.
The engineer, Dr. John Fisher, a professor at Lehigh University in Bethlehem, Pa., said the metal effectively becomes a battery under those circumstances with a small electrical current generated by the flow of water. The product, he said, is similar to the acidic corrosion seen on car batteries.
''The steel becomes a sacrificial anode,'' Dr. Fisher said. ''The metal consumes itself.''
Commissioner Sandler and other officials who were involved in the bridge's shutdown said that what specifically led them to their decision on Tuesday night to close the bridge was less the damage already discovered than the indications - some almost intuitive - of further and perhaps more serious decay.
The Transportation Department's chief engineer, Samuel I. Schwartz, said one major thing that led him to support a shutdown was a whining metallic noise he heard from somewhere inside the bridge beginning on Monday. The noise, which was recorded for study but has not been explained, was described by those who heard it as a squealing orcrcreeching soundwhwhich was thenbrbrubtly cut off ndnd followed by b bang. ''Something Gog'g'
''Thawawas one of the most frightening things,'' Mr. Schwartz said. ''It was the sound of something going.''
Mr. Schwartz, the first deputy commissioner in the city's Department of Transportation, said however that despite such omens it was not until late Tuesday afternoon that the drama began in earnest. Between 3:30 and 4 P.M., a call came in from an inspector on the bridge reporting that a roadway beam on the Manhattan side was nearly 90 percent eaten away. That damage had not been reported before.
A city engineer was dispatched and the findings were verified. Shortly after 5, Mr. Schwartz said he called his staff together and told them to prepare for a possible shutdown.


text:
Effective Monday, February 23, 2015, the NewJour website will no longer be updated, and new journal announcements will no longer be sent to subscribers. At this time, you can still search the NewJour database but no new information is being added.
You may find alternative discovery tools, such as DOAJ, GoogleScholar, or Open Science Directory, to be replacements for the NewJour service.
If you have questions or comments, please contact the NewJour Project Manager at email@example.com.


text:
Evaluation of lymphocytes CD4+ and CD8+ and expression of ZAP-70 kinase on CD3+ and CD19+ lymphocytes in obese patients undergoing laparoscopic cholecystectomy
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s00464-012-2527-6
- Cite this article as:
- Torres, K., Torres, A., Chrościcki, A. et al. Surg Endosc (2013) 27: 872. doi:10.1007/s00464-012-2527-6
- 538 Downloads
Obesity has become a global epidemic and a leading metabolic disease in the world. Laparoscopic surgeries may influence the function of the immunologic system. The percentages of CD4+ and CD8+ T lymphocyte cells have been described as prognostic factors for patients undergoing abdominal surgeries. This study aimed to evaluate the changes in CD4+ and CD8+ T lymphocyte cells, the ratio of CD4+ to CD8+ cells, and the ZAP-70 kinase expression on T CD3+ and B CD19+ cells in obese and normal-weight individuals undergoing laparoscopic cholecystectomy (LC).
The study group consisted of 46 asymptomatic patients with gallstones shown by ultrasound examination but without signs of any gallbladder complications. The patients underwent planned LC. Blood samples were obtained at three times, and the percentages of studied cells were measured by flow cytometry. Patients were enrolled to two groups: N group (body mass index [BMI], ≤25 kg/m2) and O group (BMI, ≥30 kg/m2). For statistical analysis, the Mann–Whitney U test and the Wilcoxon matched-pairs signed-ranks test were used. All p values lower than 0.05 were considered significant.
The percentage of CD4+ T cells did not differ between the N and O groups before or after the surgery. Only in the N group did the percentage of CD4+ lymphocytes increase from 0 to 48 h. A higher percentage of CD8+ lymphocytes was observed in the O group postoperatively than in the N group. Differences of ZAP-70 kinase expression in the O group were observed at 24 and 48 h of the study. Decreased expression of ZAP-70 kinase was shown in the N group at both 0–24 and 24–48 h. In the O group, this tendency was noted at 24–48 h.
Immunologic activation after LC was confirmed in both weight groups. However, higher modulation, more typical for open surgeries, was observed in the obese group.
KeywordsLaparoscopy Obesity Pneumoperitoneum T cells ZAP-70 kinase CD4+ CD8+
According to the World Health Organization, obesity has become a global epidemic and a leading metabolic disease in the world [1, 2]. Obesity is associated with a higher incidence of cardiovascular diseases, metabolic disorders, and alterations in the immunologic profile [3]. The effect of carbon dioxide pneumoperitoneum used during minimally invasive surgeries on the immunologic function has not been fully explained, especially in obese individuals (BMI, >30 kg/m2) [4, 5].
Percentages of CD4+ and CD8+ T lymphocyte populations together with the CD4+ to CD8+ ratio were found to predict the outcome for patients undergoing abdominal surgeries [6]. In selective activation of lymphocytes, ZAP-70 kinase plays an important role and was detected on both lymphocytes T and B. As a cytoplasmic protein tyrosine, ZAP-70 kinase initiates a T cell response through the antigen receptor [7].
Decreased expression of ZAP-70 kinase was observed in patients with immunologic disorders and cancer, whereas high levels of ZAP-70 kinase expression were observed in B cells of patients with chronic lymphocytic leukemia [7]. An increased prevalence of cancer and worse postoperative progress were observed among obese individuals [8]. However, the influence of pneumoperitoneum on the changes in the immunologic system, including populations of CD4+ and CD8+ lymphocytes as well as ZAP-70 kinase expression in obese individuals, were not fully explained [4].
This study aimed to evaluate changes in CD4+ and CD8+ populations of T lymphocytes, the CD4+ to CD8+ ratio, and the expression of ZAP-70 kinase on T CD3+ and B CD19+ cells in obese and normal-weight individuals undergoing laparoscopic cholecystectomy.
Materials and methods
The study investigated patients with cholelithiasis admitted to the General and Oncological Surgery Department of the District Specialist Hospital of Lublin, Poland. All the patients were informed about the aims of the study, and written consent was obtained from each patient. The study was approved by the Ethical Committee at the Medical University of Lublin (decision no. KE-0254/240/2008).
The study group consisted of 46 asymptomatic patients with gallstones shown by ultrasound examination but without signs of any gallbladder complications (e.g., empyema, hydrops, wall necrosis, jaundice, and others). The exclusion criteria specified symptoms of acute cholecystitis as well as a history of diabetes and immunologic disorders or allergies.
All the patients underwent laparoscopic cholecystectomy with standard values of carbon dioxide pneumoperitoneum (12–14 mmHg). The patients underwent surgery performed via a four-trocar technique. Anatomic recognition of Calot's triangle was performed in each case. The cystic duct and cystic artery were clipped and cut. The gallbladder with Calot's triangle lymph node was removed in a medical protector through the incision below the umbilicus. No complications during the postoperative period were reported for any of the patients. In each case, the gallbladder was evaluated by pathologic examination, and no malignancy was observed.
Blood collection
Blood samples were obtained before the surgery as well as 24 and 48 h after the surgery.
Flow cytometric evaluation
Whole blood samples (100 μL) and mononuclear cells (1 × 106 cells/mL) from Calot's triangle lymph node were stained with fluorochrome-conjugated antibodies anti-cell-surface markers and incubated for 15 min in darkness and room temperature. The cells were stained with the following antibody conjugates: anti-CD45 FITC/anti-CD14 PE, anti-CD4 FITC/anti-CD8 PE, and anti-CD3 FITC (Becton–Dickinson, San Jose, CA, USA).
Negative control condition
The fluorescence-minus-one method or the unstained cell was used. At the end of the incubation, Cytofix/Cytoperm solution (Becton–Dickinson) was added to the samples, and incubation continued for next 15 min. The cells were washed and analyzed by flow cytometry on a FACSCalibur instrument (Becton–Dickinson). After fixing, the cells were stained with anti-CD3 FITC antibodies and pelleted.
Intracellular ZAP-70 kinase detection
The BD Perm/Wash buffer (Becton–Dickinson) and anti-ZAP-70 PE (Becton–Dickinson) were added to the appropriate tubes and incubated for 15 min in darkness and room temperature. Finally, the cells were washed and analyzed by flow cytometry. For each analysis, 20,000 events were acquired and analyzed using CellQuest software (Becton Dickinson, Franklin Lakes, New Jersey, USA).
Statistical analysis
The Mann–Whitney U test was used to assess differences between studied patient populations. Differences from baseline within each group were evaluated using the Wilcoxon matched-pairs signed-ranks test. All p values lower than 0.05 were considered significant. Statistical analysis was performed using 16.0 SPSS software (SPSS, Chicago, IL, USA).
The patients were assigned to one of two groups: group N (n = 23, BMI ≤25 kg/m2) and group O (n = 23, BMI ≥ 30 kg/m2). The median age of the patients in both groups was 55 years, ranging from 21 to 71 years in group N and from 27 to 76 years in group O. The ratio of female to male patients was 16:7 in both groups. The two groups differed significantly in terms of BMI (p < 0.001). The BMI was 22.65 kg/m2 (range, 18.29–24.98 kg/m2) in group N and 31.96 kg/m2 (range, 30.02–40.39 kg/m2) in group O.
The two groups did not differ significantly in duration of surgery. The median duration of surgery was 50.50 min in group N and 45.00 min in group O. Before the surgery, each patient was assessed according to the American Society of Anesthesiology (ASA) scale, and statistical analysis did not show any significant differences between the two groups. Additionally, no differences in biochemical (aspartate aminotransferase, alanine aminotransferase, creatinine) or hematologic (hemoglobin, hematocrit, platelets) Query parameters were observed in examinations before or after the surgery. The median body temperatures and white blood counts (WBC) were similar (normal ranges) in both groups during the postoperative period. No complications (e.g., fever or wound infections) were observed during the postoperative period in either study group.
A higher percentage of CD8+ T cells was observed 24 h after surgery in the obese group than in the normal-weight group. No differences in percentage of CD8+ T cells were observed before and 48 h after the surgery between the groups. A significant increase in the percentage of CD8+ T cells was observed in obese group compared with the levels before surgery and 24 h after surgery. At the same time, a significantly decreased percentage of CD8+ T cells was observed in group N. Comparison of CD8+ T cell percentage values between postoperative hours 24 and 48 showed a significantly increased percentage in the normal-weight group and a decrease in the obese group (Fig. 1B).
The ratio of CD4+ to CD8+ lymphocytes was evaluated in the study groups before surgery and then 24 and 48 h afterward (Fig. 1C).We observed a significantly higher ratio of CD4+ to CD8+ lymphocyte cells in the normal-weight group 24 h after the surgery than in group O. The ratio of CD4+ to CD8+ T cells increased significantly in group N between the time before surgery and 24 h after the surgery compared with group O, which showed a significantly decreased ratio. In the obese group, the ratio of CD4+ to CD8+ T cells significantly increased between 24 and 48 h after the surgery.
No differences in percentage of CD19+/ZAP-70 kinase B cells were observed between the groups during the postoperative period (Fig. 2B). However, the percentage of CD19+/ZAP-70 kinase B cells increased significantly before the surgery and 24 h afterward in group N compared with group O.
The ZAP-70 kinase expression on CD3+ T lymphocytes isolated from the Calot's triangle lymphatic node showed no significant differences. However, a higher percentage of CD19+/ZAP-70 kinase B cells of Calot's triangle lymphatic node were observed in group O. The results are presented in Fig. 2C.
Despite its low invasiveness, laparoscopic cholecystectomy impairs immunologic balance, especially in obese individuals [9]. Di Vita et al. [10] reported the association between increased intraabdominal pressure and immunologic alteration in obese patients. Excessive fat tissue often is increased due to excessive fat accumulation in obese individuals, causing increased intraabdominal pressure. Consequently, carbon dioxide pneumoperitoneum used during laparoscopic procedures for this group of patients influences the cardiopulmonary, nervous, and immunologic systems to a greater extent [8, 11]. In addition, immunologic changes in the fatty tissue of obese individuals also were observed in a number of studies [12, 13]. Taken together, these data suggest that the immunologic response to operative trauma connected with laparoscopic procedures could be different for patients with a highly increased BMI.
The response of the immunologic system of obese individuals to carbon dioxide pneumoperitoneum remains complex and unclear [14]. Findings show that CD4+ and CD8+ T cells play an important role in the immunologic response after surgery [14]. The maturation of CD4+ and CD8+ lymphocytes requires transduction of the T cell antigen receptor, which takes place in the thymus and involves tyrosine phosphorylation of the protein tyrosine kinase ZAP-70 by p56(lck) [15].
Findings have determined that ZAP-70 kinase is a key signal transduction molecule in T cells. Activated CD4+ T cells play a significant role in several autoimmunologic disorders such as rheumatoid arthritis and in the postoperative response [16]. Pelekanou et al. [17] observed a decrease of CD4+ T cells in patients with sepsis. However, the cellular and molecular mechanism of T cell activation in septic patients remains unclear [18].
In our study, the percentage of CD4+ T cells did not differ between the normal-weight (N) and obese (O) groups at any of the studied time points. However, only in the normal-weight group was the percentage of CD4+ lymphocyte cells increased within 48 h after the beginning of the surgery. No such phenomenon was observed in the obese group, which showed no significant change in the percentage of CD4+ cells.
Other authors have described similar changes as favorable prognostic factors and found them more characteristic of laparoscopic techniques than of open surgery [19]. Our study showed a higher percentage of CD8+ T cells in the obese group during the postoperative period. A similar cytotoxic immunologic response was observed by other authors in obese patients and patients undergoing conventional operations. Higher levels of CD8+ T lymphocytes suggest that the immunologic balance is impaired in favor of the cytotoxic cell-mediated response in the obese group [6].
Lausten et al. [19] observed a decrease in circulating CD4+ lymphocyte cells in patients who underwent surgery by conventional methods compared with those who had laparoscopic surgery. The data obtained in our study may suggest that the immunologic response of obese patients recovering from laparoscopic short-term procedures has a greater resemblance to the response of patients who underwent a conventional laparotomy. Similar observations were made by other authors for patients undergoing open cholecystectomy versus laparoscopic techniques [20]. Whitson et al. [21] observed a greater decrease in cytotoxic response in patients subjected to laparoscopic techniques than in those who underwent laparotomy. In the study performed by Bolla and Tuzzato [14], greater impairment of cell-mediated immune function after surgery was characteristic of patients who had surgery via the open technique compared with those subjected to laparoscopic techniques.
Our study showed no differences in ZAP-70 kinase expression between the study groups during the preoperative period. Such observation might suggest that the metabolic and immunologic activity of the fatty tissue does not impair the expression of ZAP-70 kinase in obese individuals and that the activation of T cells observed by other authors might therefore occur through a different pathway [2].
Our study showed, for the first time, differences of ZAP-70 kinase expression in the obese patients at both the 24th and 48th hour of the study compared with the normal-weight group. Decreased expression of ZAP-70 kinase was present in group N both between 0 and 24 h and between 24 and 48 h after surgery. This observation suggests a decreased immune activation compared with the obese group. In the obese group, a similar tendency was observed between 24 and 48 h after surgery.
The aforementioned data imply that the expression of ZAP-70 kinase is delayed and altered in the obese group. Such alteration might influence the activation of T lymphocytes in the early postoperative period and could explain the decreased levels of CD4+ T cells observed in obese individuals undergoing surgical procedures.
To evaluate the association between the local inflammatory status and the systemic expression of ZAP-70 kinase, the lymph node from Calot's triangle was obtained and evaluated. The expression of ZAP-70 kinase on CD3+ T and CD19+ B cells was assessed. We did not find any differences in the inflammatory status between the study groups.
Injury and surgical trauma stimulate the regulation of CD4+ lymphocyte cells, and T cell receptors connected with ZAP-70 kinase are involved in this process. Upregulation of ZAP-70 kinase has been observed in the early activation of T cell receptors after burn injury [18]. Negishi et al. [22] showed that T cell development in ZAP-70 kinase-deficient mice was arrested at the transition from the CD4+ and CD8+ cells. Hanschen et al. [23] demonstrated the potential use of the phosphor-flow cytometer to evaluate the expression and upregulation of ZAP-70 kinase on T cells.
To date, altered expression of ZAP-70 kinase expression has been described in severe combined immunodeficiency disease (SCID) and chronic lymphocytic leukemia (B-CLL). Additionally, in both diseases, ZAP-70 kinase was considered a prognostic factor [7]. In obese individuals, activation of T cells might be induced by chronic low-grade inflammation, which is present in the fatty tissue and could be responsible for alterations of the immunologic response [24]. Arpaia et al. [25] observed that ZAP-70 kinase-deficient patients had no functional T cells. The proper activation of T cells might be essential for the proper wound healing and recovery after surgery [5].
Laparoscopic operations better preserve the distribution of T lymphocytes and maintain an elevated ratio of CD4+ to CD8+ lymphocyte cells, which is considered a prognostic factor [26]. In our study we confirmed the alteration of ZAP-70 kinase expression in obese patients after surgery, which could in turn influence levels of CD4+ lymphocytes and decrease the CD4+ to CD8+ (lymphocyte cells) ratio in favor of the cytotoxic component. The obtained results might be related to the short duration of the laparoscopic surgery and the lower activation of the immunologic system. However, no studies have described the expression of ZAP-70 kinase in obese patients undergoing laparoscopic surgeries. Further studies are required for a full explanation of these preliminary observations.
Although several studies have described immunologic changes after laparoscopic surgeries, our study did not show any correlations between immunologic alterations and complications during the early postoperative period. This could be due to the fact that the study was performed in a low-morbidity population of surgical patients and the operative times were short. However, we still could detect some differences in the studied immunologic parameters between obese and normal-weight individuals. The result of our study suggested that a potential to proper immunologic response induced by laparoscopic surgical trauma was better preserved in nonobese patients. The reason for this cannot be fully explained currently and could be connected with both endogenous and exogenous factors.
Nevertheless, our observations seem to have clinically important implications regarding the use of laparoscopic technique for obese patients. Increased abdominal pressure induced by carbon dioxide pneumoperitoneum is considered one of the negative factors connected with laparoscopy. Therefore, low-pressure pneumoperitoneum technique could be more beneficial for obese patients.
Immune disturbances after laparoscopic cholecystectomy were observed both in patients with normal BMI and in obese patients. However, a higher modulation, more typical for open surgeries, was observed in the obese group.
This work was supported by the Polish Ministry of Science and Higher Education (Grant #N N403 102640 to K.T.).
Kamil Torres, Anna Torres, Andrzej Chrościcki, Ryszard Maciejewski, Sebastian Radej, Jacek Roliński, Łukasz Pietrzyk, and Grzegorz Wallner have no conflicts of interest or financial ties to disclose.
Open Access
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.


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Blacks On Blondes Natalie Norton
Added: Tuesday, November 29, 2011
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Blacks On Blondes Natalie Norton
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