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Plasma cortisol and faecal cortisol metabolites concentrations in stereotypic and non-stereotypic horses: do stereotypic horses cope better with poor environmental conditions?
I don't know (editor will assign section)
Stereotypic behaviours,
Results showed that 1) plasma cortisol and faecal cortisol metabolites concentrations did not differ between horses displaying stereotypic behaviours and non-stereotypic horses and 2) both oral and motor stereotypic behaviour levels did not predict plasma cortisol or faecal cortisol metabolites concentrations.
Cortisol measures, collected in two large samples of horses using both plasma sampling as well as faecal sampling (the latter method minimizing bias due to a non-invasive sampling procedure), therefore do not indicate that stereotypic horses cope better, at least in terms of adrenocortical activity.
Stereotypic behaviours are repetitive behaviours induced by frustration, repeated attempts to cope and/or brain dysfunction
Here we investigated specific correlates of oral and motor stereotypic behaviours and glucocorticoid levels in two large and very different samples of domestic horses kept in sub-optimal conditions and already known to experience poor welfare states
Study 1
Stereotypic behaviours were observed in 65% of the horses in a total of 30 minutes of observation (9/12 horses in school 1, 18/26 in school 2 and 9/17 in school 3, chi-square test:
Whether or not the horse displayed at least one stereotypic behaviour did not predict pC concentration (
Figure 1
Plasma cortisol concentrations (ng/mL) function of oral (A) and motor (B) stereotypic behaviours frequencies in horses from riding schools (study 1, N = 55)
Plasma cortisol concentrations (ng/mL) function of oral (A) and motor (B) stereotypic behaviours frequencies in horses from riding schools (study 1, N = 55). Plasma cortisol concentrations were assessed two times per horse (between 18:00 and 19:00) and averaged. Original data are presented for clarity (plasma cortisol concentrations were Box Cox-transformed and stereotypic behaviours were log-transformed for analysis). Neither oral nor motor stereotypic behaviours frequencies predicted plasma cortisol concentrations (respectively
Figure 2
Faecal cortisol metabolites concentrations (ng/g) function of oral (A) and motor (B) stereotypic behaviours frequencies in horses from riding schools (study 1, N = 55)
Faecal cortisol metabolites concentrations (ng/g) function of oral (A) and motor (B) stereotypic behaviours frequencies in horses from riding schools (study 1, N = 55). Samples were collected between 12:00 and 13:00, three times per subject: a sample on two different days, each 24 h after a day's work and one sample 24 h after a day's rest, then averaged. Original data are presented for clarity (data were log-transformed for analysis). Neither oral nor motor stereotypic behaviours frequencies predicted faecal cortisol metabolites concentrations (respectively
Study 2
Stereotypic behaviours were observed in 24% of the horses (14/58, median frequency = 0.1, Q1 = 0.0, Q3 = 0.1 scans, range: 0–22) and were distributed as follows: weaving (9 horses), box walking (5 horses), repetitive door kicking (1 horse), head nodding (1 horse) and lip play (1 horse) (median number of scans and ranges shown in Table
Again, whether or not the horse displayed at least one stereotypic behaviour did not predict fCM concentration (
Figure 3
Faecal cortisol metabolites concentrations (ng/g) function of number of scans in which a stereotypic behaviour was observed in Arab mares (study 2, N = 58)
Faecal cortisol metabolites concentrations (ng/g) function of number of scans in which a stereotypic behaviour was observed in Arab mares (study 2, N = 58). Samples were collected between 08:00 and 10:00. Original data are presented for clarity (data were log transformed for analysis). The number of scans in which a stereotypic behaviour was observed did not predict faecal cortisol metabolites concentrations (
Here we investigated specific correlates of oral and motor stereotypic behaviours and glucocorticoid levels in two large and different samples of domestic horses, kept in sub-optimal conditions and already known to experience poor welfare states. We used plasma and also non-invasive faecal sampling to measure cortisol levels. According to the coping hypothesis of stereotypic behaviours –
Our results confirm the earlier findings of Pell and McGreevy
Using faecal samples however might also raise a new methodological issue, namely a potential impact of variations in gut flora on the concentrations of cortisol metabolites. Indeed, the metabolites of cortisol that are measured in faeces are the products of extensive modification by bacteria in the gut (e.g.
The idea that stereotypic behaviours may help animals to cope with sub-optimal environments is not new
Note also that, as reported in the literature, differences in cortisol levels between stereotypic and non-stereotypic horses do not support the coping hypothesis prediction. Indeed, McGreevy and Nicol
On the whole, our results also do not support the coping hypothesis prediction, though several explanations for these negative results can be proposed. The absence of difference between stereotypic and non-stereotypic horses might reflect equally low cortisol levels, an interpretation which would, at least partly, support a coping function of stereotypic behaviours. Bearing in mind however that horses can express poor welfare states in various ways (
Another possible explanation for the results is that chronic stress levels might not be accurately measured by basal cortisol concentrations
Beyond the potential functional explanation of stereotypic behaviours proposed by the coping hypothesis, another explanation for our negative findings may be that the performance of stereotypic behaviour is not associated with stress or coping at all. Indeed, some forms of stereotypic behaviours are preservative and animals cannot stop performing them
This is, to our knowledge, the first time that a non-invasive measure of cortisol (
All our experiments complied with current French laws related to animal experimentation and were in accordance with the European directive 86/609/CEE. The local Ethics Committee in Animal Experiment of Rennes gave a favourable opinion to perform both studies. No licence/permit/institutional ethical approval were needed from the local Ethics Committee in Animal Experiment of Rennes (study 1) as the work respected French regulations and blood samples were obtained in presence of a veterinarian doctor. No licence/permit/institutional ethical approval were needed for study 2 according to the Tunisian regulations, as only behavioural observations and non-invasive sampling (in presence of the veterinarian doctor of the breeding facility) were performed. In both studies, animal husbandry and care were under management of the riding schools and breeding facility staff, as this experiment involved only horses "from the field" (no laboratory animals).
Study 1
Fifty-five horses (37 French Saddlebred and 18 diverse breeds and unregistered horses) from three riding schools (
Study 2
Fifty-eight purebred Arab mares were observed from the 30th March to the 15th of May 2005 at the national stallion breeding facility of Sidi Thabet, located 20 km from Tunis in Tunisia. Mares are brought to this facility every year in order to breed with the stallions housed there. None of the mares were pregnant at the time of the study, but they belonged to three different reproductive categories: foaling mares (mares mated/inseminated in the facility where we conducted this study with a foal at foot that was born and bred in the facility,
Behavioural observations
These two complementary studies were part of two different research projects (one performed in 2005 and the other in 2007); behaviour sampling methods therefore differed between study 1 and study 2.
Study 1
Each horse was observed by a single observer (CF) in its box using a focal sampling method
Study 2
Observations were made by a single observer (HB) every day during 46 days using instantaneous scan sampling. Twice a day (once in the morning before feeding and once in the evening after feeding), the observer walked through along the stalls and noted the behaviour of each of the mares at the instantaneous time of her passage. The time budget for each behaviour was determined as the recorded number of each behaviour divided by the total recorded number of scans in each horse. Previous observations and preliminary observations indicated that two such scans are enough to identify stereotypic animals, especially over a longer time period as was the case in this study
Although we recorded all behavioural patterns in both studies, presented data are limited to stereotypic behaviours. The oral and motor stereotypic behaviours observed are reported in Table
Physiological data: adrenocortical activity
Plasma cortisol measurement (study 1)
We aimed to minimise the aversive effects of blood sampling, which was confirmed by the absence of any retreat behaviour of the horses. Each horse was lightly restrained by a single experimenter who was unknown to the horse (SH) and systematically given a food reward (one sugar lump) at the end of each blood sampling. Sampling was made by a single experimenter (CF) and the total duration of the procedure did not exceed one minute. Blood samples were collected from the left jugular vein two times per horse between 18:00 and 19:00 over 2 consecutive days: once after a day's work and once after a day's rest. The initial protocol also included morning sampling. Preliminary analysis however revealed a limitation of our method. Morning cortisol concentrations were highly influenced by the time of sampling (Fureix et al. in prep), more particularly in regards to the time passed between the dawn and the actual time of sampling (an interval which was likely to differ from January to May). We therefore excluded morning samples from analyses in the present study.
Seven ml of blood were collected in heparinised polypropylene tubes (BD Vacutainer®). Samples were kept on crushed ice until centrifugation (with a maximal delay between sampling and centrifugation of 15 min) and then aliquots of plasma were immediately placed on dry ice and stored at −20°C for further processing. Plasma cortisol levels were measured using radioimmunoassay Immunotech kits for cortisol determination (Beckmann and Coulter). These kits are usually used for measuring human plasma cortisol. We modified the manufacturer's method so that it could be used for equine plasma that contains more interfering proteins: 1) the quantity of plasma per dose was 25 μL instead of 50 μL; 2) a two-hour preliminary incubation at 20°C between plasma and antibodies was added; 3) we used two standard curves: the first with increasing cortisol concentrations in buffer (as indicated by the manufacturer) and the second with increasing cortisol concentrations in equine plasma (diluted in a pool sample of equine plasma containing low cortisol levels). These modifications produced linear curves (log B/Bo) between 2 ng/mL and 300 ng/mL. A good linearity was observed for dilution or overload experiments. The coefficient of variation (one sample measured seven times in the same assay) was 1.37%. Note that the range of absolute pC concentrations we obtained was apparently comparable to the data reported in the literature, keeping however in mind that absolute values are highly method dependent (and thus may vary by a factor of 2, or even more).
Faecal cortisol metabolites measurement (study 1 and study 2)
Fresh faecal samples were collected immediately (less than 1 minute) after defecation directly from the bedding. In study 1, samples were collected between 12:00 and 13:00, three times per subject: two samples were collected on two different days, 24 h after a day's work and, a third sample was collected 24 h after a day's rest (taking the 24 h delay in excretion of fCM in horses into account;
Each faecal sample was then kept frozen at −20°C until further analysis. Extraction of samples followed the method described by Merl et al.
Data and statistical analyses
Behavioural data collected were frequencies (per min, as the total time of observation was less than one hour) of oral and motor stereotypic behaviours (study 1) and number of scans performing a stereotypic behaviour (study 2). Only one out of the 58 horses displayed an oral stereotypic behaviour (in addition to its motor stereotypic behaviours), therefore the distinction between oral and motor stereotypic behaviours was not relevant in study 2. Physiological data collected were plasma cortisol (pC, ng/mL, study 1) and/or faecal cortisol metabolites (fCM, ng/g, studies 1 and 2). Cortisol levels after a day's work and after a day's rest were positively correlated (Spearman correlation tests: plasma
Analyses were conducted in JMP 9.0.2. (SAS Institute Inc., Cary, NC, USA) (accepted
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
CF designed the study 1, collected physiological and behavioural data, performed the statistical analyses and drafted the manuscript. HB designed the study 2 and collected physiological and behavioural data. SH helped to collect the physiological data in study 1. AB, AP, ME, CC carried out plasma cortisol measurements. MH designed both studies and drafted the manuscript. RP carried out faecal cortisol measurements, helped to perform the statistical analyses, and drafted the manuscript. PJ designed the study 1. All authors read and approved the final manuscript.
The authors are grateful to the directors of the riding schools and their staffs for allowing us to work with their horses and for their help and understanding. The authors wish to thank all the staff of FNARC (Fédération Nationale d'Amélioration de la Race Chevaline, Tunisia) for providing the facilities to complete this study. We are grateful to L Dupont and C Lavertue for their help with data collection. We also thank A-M Mounier (INRA-UMR SENAH) and E Klobetz-Rassam (University of Veterinary Medicine, Vienna) for their technical help. The authors are grateful to R Meagher, M Buob and L Schnablegger (Writing and Learning Services, University of Guelph) for correcting the English of this manuscript, and to R Meagher and G Mason for helping analysing data. This manuscript benefitted from comments from two anonymous reviewers. This work was supported by a grant from the Caisse Centrale de la Mutualité Sociale Agricole. The funders had no role in the study design, data collection and analyses, decision to publish or preparation of the manuscript. The authors report no conflicts of interest.
Stereotypic behaviour in captive animals: fundamentals and implications for welfare and beyond
Why and how should we use environmental enrichment to tackle stereotypic behaviour?
Stereotypic oral behaviour in captive ungulates: foraging, diet and gastrointestinal functions
Increased reproductive output in stereotypic captive Rhabdomys females: Potential implications for captive breeding
Reproductive status and stereotypies in breeding mares: A brief report
The putative welfare-reducing effects of preventing equine stereotypic behaviour
A study of cortisol and beta-endorphin levels in stereotypic and normal Thoroughbreds
The ethological and physiological characteristics of cribbing and weaving horses
Circadian variation in ghrelin and certain stress hormones in crib-biting horses
Relationship between plasma cortisol and stereotypic activities in pigs
Faecal glucocorticoid level is not correlated with stereotypic pacing in two captive margays (Leopardus wiedii)
Physiological and behavioral consequences associated with short-term prevention of crib-biting in horses
Behavioural and physiological responses to an acute stressor in crib-biting and control
Selection against stereotypic behaviour may have contradictory consequences for the welfare in farm mink (Mustela vison)
Behavioural repertoire: its expression according to environmental conditions
A note on the time budget and social behaviour of densely housed horses - A case study in Arab breeding mares
Partners with bad temper: reject ou cure? A study of chronic pain and aggression in horses
Co-occurrence of yawning and stereotypic behaviour in horses Equus caballus
Towards an ethological animal model of depression?
The effect of increasing visual horizons on stereotypic weaving: implications for the social housing of stabled horses.
Management factors associated with stereotypic and redirected behavior in the thoroughbred horse
Human direct actions may alter animal welfare, a Study on Horses (Equus caballus)
The effect of two different housing conditions on the welfare of young horses stabled for the first time
Repetitive movement problems in the horse
Perseveration and stereotypy - Systems-level insights from clinical psychology
Could work be a source of behavioural disorders? A study in horses
Effects of repeated jugular puncture on plasma cortisol concentration in loose housed dairy cows
Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones
Effects of reproductive status and management on cortisol secretion and fertility of oestrous horse mares
Pain causes increased concentrations of glucocorticoid metabolites in horse feces
Faecal cortisol metabolites in Quarter Horses during initial training under field conditions
Excretion of infused C-14-steroid hormones via faeces and urine in domestic livestock
Monitoring stress hormone metabolites as a useful, non-invasive tool for welfare assessment in farm animals
Exploration of the hypothalamic-pituitary-adrenal function as a tool to evaluate animal welfare
Measuring fecal steroids - Guidelines for practical application
Stress hormones in mammals and birds - comparative aspects regarding metabolism, excretion, and noninvasive measurement in fecal samples. Trends in comparative endocrinology and neurobiology
Study of crib-biting and gastric inflammation and ulceration in young horses
On the use of non-invasive hormone research in uncontrolled, natural environments: the problem with sex, diet, metabolic rate and the individual
Developmental aspects of motivated behavior in domestic animals
Animal welfare: concepts and measurement
Stereotypies: a critical review
The coping hypothesis of stereotypic behaviour. Box 3, Chapter 1
Relationships between behaviour and health in working horses, donkeys, and mules in developing countries
Problems associated with the interpretation of physiological data in the assessment of animal-welfare
Plasma concentrations of cortisol and corticosterone in normal horse
Adrenocortical function in horse
Circadian variation in plasma cortisol and corticosterone in pigs and mares
Diurnal- variation of plasma corticosteroids in wild horse stallion
Daily rhythm of cortisol, and evidence for a photo-inducible phase for prolactin secretion in nonpregnant mares housed under noninterrupted and skeleton photoperiods
Factors affecting the circadian rhythm in plasma cortisol concentration in the horse
If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans
Impaired instrumental choice in crib-biting horses (Equus caballus)
Stereotypies and suffering
Observational study of behaviour: sampling methods
Measurement of cortisol metabolites in faeces of sheep as a parameter of cortisol concentration in blood
Measurement of glucocorticoid metabolite concentrations in faeces of domestic livestock


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Chesapeake Bay Crab Cakes
julie cranfill
- 1
- egg
- 1 tsp
- sharp prepared mustard
- 1 Tbsp
- lemon juice, fresh
- 6 Tbsp
- olive oil, divided
- 1/2 tsp
- salt
- pinch
- pepper
- 1 lb
- lump crabmeat, picked clean
- 1/2 c
- bread crumbs, plain
- 4 Tbsp
- butter
- parsley
- 1
- lemon wedges
- tarter sauce
- cayenne pepper
1Using an electric blender or wire whisk, beat together mustard, lemon juice and egg until thoroughly combined.
2While beating vigorously, gradually pour 4 tablespoons of olive oil into the egg mixture in a thin stream.
3When smooth and creamy, stir in salt and pepper.
4Gently fold in crabmeat, then bread crumbs and cayenne pepper.
5Shape into 8 patties, each about a half-inch thick.
6They will want to fall apart, but that's the idea of a good crab cake.
7You want only enough non-crab stuff to just barely bind them.
8Melt butter together with remaining 2 tablespoons of olive oil in skillet over medium heat.
9When butter sizzles (but before it burns!) gently ease the crab cakes into the skillet to cook.
10When well browned (2 to 3 minutes), gently turn and cook other side. Drain on paper towels.
11Serve immediately with parsley, lemon and tartar sauce, if desired.
12Makes 4 main-course servings, 8 appetizers.
About Chesapeake Bay Crab Cakes
Course/Dish: Seafood Appetizers
Other Tag: Quick & Easy


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What is whisky?
Whisky is any spirit distilled from fermented grain, to qualify as scotch the spirit must be made from malted barley. Many scotches use nothing more than barley water and yeast. You are allowed to use other grains but no additives or short cuts are permitted. The spirit must be aged in oak barrels for no less than three years and finally you cannot call your product Scotch whisky unless it has been made 100% in Scotland.
Bourbon is whisky made from a grain mixture which is at least 51% corn. Much like Scotch must be made in Scotland, Bourbon must be made in the United States.
Bourbon has no minimum aging period but to call your product Straight bourbon it must be aged for no less than two years in wooded barrels.


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Scene Twelve
the castle
ENSEMBLE remain where they are. ANNA and SISTER are CS.
ANNA: Narrators! You have to help me!
NARR. 1: What do you want us to do?!
ANNA: I have three brothers who live near here. Go and tell them my husband is about to murder me! Quickly!
NARR. 2: Okay, I'll go.
NARR. 2 exits SL.
ANNA: (calling after him) Be quick!


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Director Mysskin made the Tamil film Mugamoodi. The film's Telugu version is titled Mask. Jiva plays the superhero A special superman costume was designed by Hong Kong designers. The action sequences have been designed and coordinated by Tony of Bruce Lee's Enter The Dragon fame. Music is composed by Sathya. Pooja Hegde, Narain and Nassar are part of the cast. The film is produced by UTV Motion Pictures. The Telugu version is being brought by RB Chowdary of Mega Super Good Films.
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Individual National – Saturday 6th August
Open for additional entries for one day only!! Due to high demand we are opening the Individual National for additional entries for one day only. MONDAY 1st AUGUST – 9am – 4pm (No one will be booked on before or after these times). If you would like to enter please call Corina on 0115 822 4532. Please have your Angling Trust Membership Number and payment details ready.


text: Greek Quesadillas with Tsatziki Recipes By Helen Schofield 15 September 2015 Ingredients For the quesadillas 7 ounces/200 grams fresh spinach 2 scallions/spring onions, chopped finely 1 tablespoon chopped dill 2.5 ounces/70 grams feta cheese 3 or 4 chopped sun-dried tomatoes (optional) 4 flour tortillas (I used 20cm-diameter ones) salt and pepper for seasoning and a little olive oil for cooking For the tsatziki sauce 1 cup/285 grams Greek yoghurt (don't use ordinary yoghurt – it's too thin) ½ a small clove of garlic, chopped finely or minced 1 medium cucumber, diced finely 1 teaspoon chopped dill a couple of squeezes lemon juice black pepper and a drizzle of olive oil Instructions Wash the spinach, then wilt it down in a pan (or even in the microwave) for a few minutes. Afterwards, squeeze out as much of the water as you can by pressing it down into a colander or even squeezing it with your hands. Put it into a large bowl. Add the chopped scallions/spring onions, dill and sun-dried tomatoes (if using) to the bowl. Then crumble in the feta. Give it all a good mix together and put aside while you make the tsatziki. For the tsatziki, put the yoghurt into another smaller bowl or dish and add the garlic, cucumber, dill and lemon juice. Mix it all together well. Grind some black pepper onto the top and drizzle over a little olive oil. Done! Now heat up a skillet/frying pan. Spread half of your spinach mixture over two of the tortillas and top with the other two. Press down a little then place one of the rounds into the pan. (the pan can be dry or you can add a drizzle of olive oil to help the tortillas to crisp up. I added a tiny bit of oil. But be careful the tortillas don't burn!) When it's nice and browned and crispy, carefully turn it over and let the other side cook for a minute or two. Repeat with the second round. Slice each round into six quesadillas and serve with the tsatziki sauce immediately. Notes If you were going to be really 'proper' about the tsatziki, after deseeding the cucumber you would sprinkle a little salt over it to draw out any excess water, leave it for a while, then dry it with paper towels. I didn't actually do either of these things, but if you do you'll end up with a thicker and I suppose more authentic tsatziki. :-) Any leftover tsatziki will keep in the fridge covered for a few days. Eat it with salads, as a dip or drizzled over grilled meat or roasted vegetables. This is actually a very versatile dip/sauce indeed! Enjoy! Tags: Snacks Lunch Category: Recipes « Back


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There is no one who has not heard about famous Uzbek plov! It is the signature food of south Kyrgyzstan and loved by everyone. Whether if you go to the weddings, birthday parties or some other events, it is impossible to imagine the dinners without this food!
What makes it so special? The main ingredients of plov are yellow carrots (literally yellow, not the orange ones we all use), meat (beef or mutton) and of course the unique brown rice, which is also grown in the country itself. The one from Uzgen city is considered as the best, yummiest and most famous around!
So, whenever you visit the south of Kyrgyzstan, do not even think of leaving it without trying real Uzbek plov made of unique veggies and Uzgen rice!


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Christian Bookstore .Net is a leading online Christian book store.
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Conquerors for Christ is anointed and illuminated Bible scholarship that will teach you how to assume and manifest the authority and power of Jesus Christ in these last days, asserting the same against, and enforcing the victory of the Cross of Christ and the power of His Resurrection over, the enemy, sin, sin nature, death, sickness, oppression and possession of demons, the false preachers, prophets and teachers in the apostate church, and the ways of the world! You will learn how to be a king and priest of Almighty God by taking dominion over the marketplace to raise provision for His vision, as well as proclaiming Jesus Christ to a lost and dying world! You will learn how to become an executor, steward and trustee of the last Will and Testament of our Lord and Savior Jesus Christ - His Gospel - thus executing His "Great Commission" and building up His Army of the Light!
Publishers Description
Conquerors for Christ teaches God's king and priest to enforce the authority and power of Jesus Christ over the enemy, church apostasy and the world, while executing Christ's "Great Commission"
Buy Conquerors For Christ by Michael James Robertson from our Christian Books store - isbn: 9781600345043 & 1600345042
The team at Christian Bookstore .Net welcome you to our Christian Book store! We offer the best selections of Christian Books, Bibles, Christian Music, Inspirational Jewelry and Clothing, Homeschool curriculum, and Church Supplies. We encourage you to purchase your copy of Conquerors For Christ by Michael James Robertson today - and if you are for any reason not happy, you have 30 days to return it. Please contact us at 1-877-205-6402 if you have any questions.
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Series: RAP Bulletin of Biological Assessment Volume: 49
308 pages, 4 plates with colour photos, 3 plates with colour maps; b/w illustrations, b/w maps
Language: Spanish with bilingual summaries in English and Spanish
Although the upper basin of Venezuela's Paragua River is in almost pristine condition, little is known about the region's biological diversity.
This volume presents the findings of a biological expedition that sought information about the use of national resources, the local population, and the state of conservation in the area. Researchers discovered several species new to science and offered conservation recommendations. Results of the survey also indicated a reduction of traditional activities, such as hunting and fishing, by the indigenous population and the progressive incorporation of mining activity.
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Josefa Celsa Señaris and Carlos A. Lasso are researchers at the Fundacion La Salle de Ciencias Naturales in Venezuela. Ana Liz Flores is executive director of Conservation International – Venezuela.


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Our Bottles
We re-use our 16 oz glass bottles because simply because we like clean living and clean eating, free of the chemicals and waste of plastic. We are committed to bottling in re-usable glass because it gives you a way of enjoying what nature has to offer at peak nutrition, with the convenience of daily serving sizes. We include a $2 bottle charge as part of individual juices that you purchase, and will happily give a discount for re-usable bottles returned to our kitchen.
For our weekly subscribers, we don't charge a deposit for the bottles as long as they are returned weekly. We ask that bottles are rinsed (not washed) and returned with the cap on so they're easier for us to clean. If bottles are not returned for an extended period of time, we'll assume you found a use for them, and the cost ($2 per bottle) will be passed on to you after 2 weeks of not receiving bottles back as part of the weekly subscription.
We know it's more work to rinse, scrub, wash and sanitize our bottles, but we know it's work worth doing, both for your health and for the health of our environment. By re-using our bottles, we are saving tremendous amounts of energy, water and pollution from degrading the earth that allows us the produce that sustains us.
Our glass bottles keep your beverage colder longer, fit in all cup holders/koozies, and (we think) are pleasant to drink out of.
They also look and feel really good to hold


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Results from a phase 2 study of enzalutamide (ENZA), an androgen receptor (AR) inhibitor, in advanced AR+ triple-negative breast cancer (TNBC).
Background: The AR may be a therapeutic target for pts with androgen-driven TNBC. ENZA, a potent AR inhibitor, is approved in men with metastatic castration-resistant prostate cancer (mCRPC) and improves median PFS compared to bicalutamide in men with mCRPC (15.7 vs 5.8 mos; HR 0.44; p<0.0001). Methods: MDV3100-11 was an open-label, Simon 2-stage study evaluating single agent ENZA in advanced AR+ TNBC (AR >0% by IHC; NCT01889238). Pts could be prescreened for AR, and have non-measurable bone disease and unlimited prior regimens; CNS metastases or seizure history were exclusionary. The primary endpoint was clinical benefit (CR, PR or SD) at 16 wks (CBR16) in 'Evaluable' pts defined as having both AR IHC ≥10% and a response assessment. CBR24, PFS, response rate, and safety were assessed. An androgen-driven gene signature (Dx) was created from gene profiling and outcomes were assessed accordingly. Stage 2 enrolled if CBR16 was ≥3 of 26 Evaluable pts; H0 was rejected if CBR16 was ≥9 in 62 yielding 85% power at 5% significance to test against a 1-sided alternative (CBR16 ≥20%). Results: As of 16 JAN 2015, 404 samples were tested for AR IHC: 79% had AR >0%; 55% had AR ≥10%. 118 pts were treated with ENZA; 43 pts were not Evaluable (29 AR <10%; 14 AR ≥10% but no response assessment). Key outcomes in the defined populations are below as shown in the Table. Over 50% received ENZA as 1st or 2nd line; mPFS in these pts was 32 wks in Dx+ and 9 wks in Dx-. Two CRs and 5 PRs have been observed. Related AEs in ≥10% of 118 pts were fatigue (34%), nausea (25%), decreased appetite (13%), diarrhea and hot flush (10%). Fatigue (5%) was the only AE ≥ Grade 3 in ≥5%. Conclusions: This is the largest study of an AR inhibitor in TNBC. IHC results suggest AR prevalence is higher than previously reported. 47% of pts had an androgen-related gene signature (Dx+) and clinical outcomes appeared superior in this group. AEs from ENZA were consistent with its known profile. ENZA may represent a novel therapeutic option in pts with TNBC who would otherwise receive cytotoxic chemotherapy. Clinical trial information: NCT01889238
|35 (24-46)
|39 (27-53)
|11 (5-21)
|29 (20-41)
|36 (24-49)
|7 (2-16)
|mPFS, wks (95% CI)
|14 (8-19)
|16 (10-32)
|8 (7-13)
Abstracts by Tiffany A. Traina:
OncoKB: Annotation of the oncogenic effect and treatment implications of somatic mutations in cancer.Meeting: 2016 ASCO Annual Meeting | Abstract No: 11583
Phase (Ph) 1 study of oral seviteronel (VT-464), a dual CYP17-Lyase (L) inhibitor and androgen receptor (AR) antagonist, in patients (pts) with advanced AR+ triple negative (TNBC) or estrogen receptor (ER)+ breast cancer (BC).Meeting: 2016 ASCO Annual Meeting | Abstract No: 1088
Phase I/II trial of palbociclib in combination with bicalutamide for the treatment of androgen receptor (AR)+ metastatic breast cancer (MBC).Meeting: 2016 ASCO Annual Meeting | Abstract No: TPS1103


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Origin-8's Ultim8 All-Mountain Double Clipless Pedals are great clipless pedals that are easy to enter and exit. They boast dual-sided SPD compatible bindings, and a composite cage for increased surface area. The bindings are adjustable for dialing in the perfect entry and exit tension and these sweet pedals have a mud-shedding design to prevent clogging. They feature chromoly axles and sealed cartridge bearings for durability, too.
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1. Re: OPA returns SOAP-Fault with HTTP 200 (OK) code!Kristy Van Der Vlist-Oracle Jan 23, 2013 11:29 PM (in response to 303145)Unfortunately it is a bug. It's being tracked and we'll have it fixed in an upcoming release. In the mean time you should be able to get OSB to route on the content of the message rather than the HTTP status code1 person found this helpful
2. Re: OPA returns SOAP-Fault with HTTP 200 (OK) code!303145 Jan 23, 2013 11:52 PM (in response to Kristy Van Der Vlist-Oracle)Yes dealing with it is no big deal, just means I have to "sniff" the content and raise an error if it is a SOAP fault to properly propagate the error to the caller.


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Lady LuckMature
Everything hurt. My head hurt, my back hurt, my hands hurt, my legs hurt. Where was Nat? We had been camping... I couldnt open my eyes. Suddenly, there were footsteps, light ones.
"How are you feeling dear?" Said a musical, female voice.
"Mmgh" I groaned, not really willing to say anything else.
The musical voice laughed. "We can take away your pain if you like." she said.
I foced my eyes to open and found myself face to face with the most beautiful creature I'd ever seen. She couldnt be human, with those big dark eyes and long golden hair that looked like it was made of actual gold. Her nose and mouth were small, accentuating those big eyes. I got lost in them as I stared, and thought I felt myself nod. Then, there was no pain. Anywhere. I reached up to feel my head, and stopped. My hand looked strange.
"The glamour is working." Said the beautiful lady, apparently not talking to me anymore. "He resisted it at first, but now its working." Another beautiful lady walked into the room, which was large and done up in what looked like pastel colored marble.
"Glamour?" I asked, confused, so my mind jumped tracks. "Where's Nat?"
"It makes you appear to be one of us." The second beautiful lady said, ignoring my second question and giving me a mirror. In it, I saw a pale skinned guy with a very straight nose and big gold colored eyes. It was a good looking face, but it was not mine. He had pointed ears as well. Definitely not my face. Someone had remodeled my entire body, I felt taller, my fingers were longer, thinner. My face was different and my hair was jet black. I could feel the panic start; someone had performed cosmetic surgery on me without my permission! What had happened to me? I liked me. Then, the first lady, the one with the musical voice, touched my forehead and I felt calm again.
"Dont worry Jay Carter." She said. "We will take care of you. You shall not want for anything here." I looked into those dark eyes, and trusted them completely.


text: Meet Sarah Wayne! Greetings from Illinois College! My name is Sarah Wayne, and I am the Associate Director for International Recruitment and Outreach. I grew up in Indiana and Illinois, and graduated from Augustana University in Sioux Falls, SD in 2000 with a Bachelor of Arts degree in International Studies, Modern Foreign Languages, and French (triple major). My experience over the last 15 years in international programming and student recruitment has allowed me the pleasure of helping students from all over the world find a great educational fit. I look forward to working with you as you find your fit at Illinois College! You may reach me at +22.214.171.12494 or via email at firstname.lastname@example.com.


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Expert Review
Shelley ElmbladFinancial Software Contributing Editor
Shelley Elmblad is a freelance writer with years of experience covering small business, personal finance and tax software and mobile apps. Shelley's goal is to help others choose the best software to run a small business, track personal finances and save money.
about Shelley→
Concur is a web-based expense management service that focuses on travel related expenses. Concur is a part of SAP, a German software company whose products allow businesses to track customer and business interactions. SAP is especially well-known for its Enterprise Resource Planning (ERP) and data management programs. Customers do not have to use SAP to use Concur. Pricing starts at $8 for a basic set of features. Features can be added like the ability to manage invoices, more detailed reporting, audit service and worldwide use in higher level packages. Expense reports are created by snapping photos of receipts using an iOS, Android, Windows Phone or Blackberry mobile device.
- Travel booking options: Managers and employees can use Trip-It Pro or global travel content to compare travel options, check for compliance with budget and other requirements, book business travel and fill out travel-related expense reports.
- Automated expense reporting: Concur offers an automated digital expense reporting service, which means that users don't have to use spreadsheets or save paper receipts. Corporate credit cards, P-Cards and personal credit card integration are available as well.
- Invoice generation: Contractors and others who require payments can generate and send payment requests with this system. Higher versions offer automatic supplier reimbursement and a supplier portal.
- Accounting software integration: Expenses and data submitted and approved in Concur can be set up to integrate with QuickBooks, Salesforce, customized hosts or web service APIs.
- Concur Connect and reports: Concur Connect is a platform that connects customers, suppliers, developers and content aggregators to access and be used to extend Concur's travel and expense reporting cloud. Reporting ranges from a few basic reports for the small business version to custom insight reporting that is powered by Cognos.
- Best for Employees who travel and independent contractors.
Compare Expense Management Software
Concur Company Profile
- Company Name:
- Concur
- Year Founded:
- 1993
- Address:
- 601 108th Ave NE Suite 1000
- City:
- Bellevue
- State/Province:
- Postal Code:
- 98004
- Country:
- United States
- Website:
- https://www.concur.com/


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Home > Consumer Conscious > A Twist on Salt
A Twist on Salt
Consumer Conscious
There it is in your kitchen, right next to the pepper shaker. You shake it on popcorn and hamburgers. You use it everyday. But unless you use it for thousands of other things, you're not taking full advantage of its magical properties.
Who knew salt is so much more than a seasoning for food? In fact, salt has more than 14,000 uses. According to the Salt Institute, an Alexandria, Virginia-based organization that represents the Salt Industry, salt can be used for everything from thawing ice to relaxing tired muscles.
While most of us think of salt in terms of seasoning our food, salt is an essential ingredient in a wide variety of consumer and industrial products, ranging from foods and animal feed to chemical feedstock and highway deicers. Life cannot exist without salt.
Salt was recognized as a necessity in human and animal nutrition more than 4,700 years ago in one of the earliest medical reference works found in ancient China. In the centuries since then, salt has been used as money, has ignited wars and was essential to preserving foods as recently as 100 years ago - before refrigeration. Salt even garnered more than 30 references in the Bible, including the infamous moment when Lot's wife looked back on the destruction of Sodom and turned into a pillar of salt.
But what about around your household? Can salt play a more versatile role than simply another ingredient in a favorite cookie recipe? You bet. Cargill Salt's Diamond Crystal brand of iodized salt (recognized by its classic red-and-white canister) can be used in dozens of applications around the home. So can other types of salt that are common to many households, including kosher salt, low-sodium salt, canning and pickling salt and sea salt.
Salt is extremely versatile. It can be used to clean kitchens and bathrooms, remove stains in clothing, relieve stress when added to a warm bath, or even extend the life of brooms and sponges.
Tricks of the Trade
As most people know, there are some foods that simply wouldn't be the same without salt - like french fries, steak or popcorn. And although most people use it every day, it still holds some surprises for food and beverages.
For instance, when enjoying a glass of red wine, sprinkle some salt into the glass to bring out the fragrance and taste of the wine. Or try adding a pinch of salt on top of citrus fruits and you will notice the fruit has a crisp taste immediately.
Around the kitchen, you may want to try boiling eggs in salted water; it makes eggs easier to peel. And to test for freshness, place an egg in a cup of water and add a couple teaspoons of table salt - a fresh egg will sink, a spoiled egg will float. Table salt is good for preventing mold on cheese (add a pinch of salt the next time you wrap your cheese in plastic wrap) and keeping milk fresher longer (add a pinch to the carton or bottle). Salt also can eliminate the burned food odor from an oven and stovetop burners, and can cut odors and prevent grease build up in sinks.
Healthwise, gargling regularly during the winter months with an iodized salt and water mixture will alleviate sore throats. For fresher breath, blend equal parts of salt and baking soda in warm water and swish. Apply cotton pads soaked in salt water (one tablespoon of salt in a pint of hot water) to reduce puffy areas around the eyes.
You may also find of interest...
- Changing Your Salt Habit
- Low Sodium Diet Decreases Blood Pressure (Fitness)
- Sodium Diet Guidelines (Fitness)
- Low Sodium Recipes
Disclaimer: The material on this Web site is not intended to replace advice from your doctor or fitness professional. Please consult with your physician before beginning any fitness program or fat or weight reduction program. FitnessandFreebies.com takes no responsibility for individual results, or any claim made by a third party.


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ED Magedson – Founder
Ripoff Report
The Best Damn Tickets Period - Eddie Flores961 Darrell St. Costa Mesa, California U.S.A.
Does your business have a bad reputation?
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Corporate Advocacy Program™
This report was posted on Ripoff Report on 09/28/2008 08:49 PM and is a permanent record located here: http://www.ripoffreport.com/reports/the-best-damn-tickets-period-eddie-flores/costa-mesa-california-92627/best-damn-tickets-period-eddie-flores-violation-of-bait-and-switch-laws-business-and-p-376807. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
Click Here to read other Ripoff Reports on The Best Damn Tickets Period - Eddie Flores
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SUBMITTED: Wednesday, October 15, 2008POSTED: Wednesday, October 15, 2008
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YITH WooCommerce Membership Premium v1.3.9 – Selling products with dedicated access is a great opportunity to increase your earnings: big companies like Udemy or Treehouse prove it, achieving huge amount of sales volumes with this business model. Their income is intended to grow considering the amount of people looking for their products.
In a completely automatic way, you could offer your users a restricted and exclusive access to tailored information, like a course, a study plan, a sequence of e-books, or even premium services, etc.
Imagine having a class of students that attend to your lessons, and that each lesson is displayed exactly when you have planned, with no errors, respecting completely your lesson plan. Imagine publishing resources and products to your customers, managing independently payments and content release: YITH WooCommerce Membership will let you do all this and even more.
Manage courses, services, valuable membership plans with private access, send messages to your customers, schedule the publication of the exclusive contents for your customer: these actions are easily achievable with YITH WooCommerce Membership, a plugin conceived and designed to tear down any difficulty for the management of reserved products for those who purchase them.
Membership is nice and ready: you just have to create the products in your shop, and the software will do the rest, leaving you free to manage your time as you want. The plugin works with pages, posts, WooCommerce files and products, videos, etc. The restricted area is easy to use, and will let you protect your work, and make it accessible only to those who paid for it.
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Mountain Hardwear Ghost Whisperer Anorak Jacket - Men's - $93.93
Perfect for fast runs and active motion, this wind-resistant Ghost Whisperer Anorak jacket from Mountain Hardwear repels light moisture and weighs in under 2 oz.. Very lightweight ripstop nylon protects core heat and resists light wind and moisture. Durable Water Repellent finish causes water to bead up and roll off, fending off light moisture. Stormy skies on the horizon? Pack jacket into the built-in pocket, grab and get out on your run. Deep zipper offers instant ventilation. Reflective highlights enhance visibility. Weighs 1.87 oz. The semifitted Mountain Hardwear Ghost Whisperer Anorak jacket is perfect for active motion. - $93.93


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Teen Wanted After School Assault
Police have issued arrest warrant for Marquez Marshall
A Columbia teen currently has a warrant for his arrest after failing to make a court date. Marquez Marshall was first taken into police custody last fall, after allegedly assaulting a teacher in the parking lot at Jefferson Junior High. Investigators claim he approached her and asked for her car keys. But when she refused, Marshall allegedly punched her in the face. Prosecutors told ABC 17 News Marshall has missed at least one court appearance.


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Harrison files for city commission, Chris Carlile also files for city seat
• L&T staff reportCandidates have now filed for four of the local boards where seats are available, according to Seward…
Democrats to meet Thursday
• Special to the Leader & TimesThe Seward County Democrats will meet at 7 p.m. Thursday in the commission chambers…
Board to discuss school boundaries
ELLY GRIMM• Leader & TimesIt looks to be another long evening for the USD 480 school board for its next…
CNA discusses challenges, rewards of nursing career
By ROBERT PIERCE• Leader & TimesTammy Bond works as a nurse at Brookdale Liberal Springs. She talked about her background…
Local News
Local Sports
High Plains Community
About The High Plains Daily Leader
The High Plains Daily Leader and Southwest Daily Times are published Sunday through Friday and reaches homes throughout the Liberal, Kansas retail trade zone. The Leader & Times is the official newspaper of Seward County, USD No. 480, USD No. 483 and the cities of Liberal and Kismet. The Leader & Times is a member of the Liberal Chamber of Commerce, the Kansas Press Association and the Associated Press.
For more, contact us.
Get the Daily Leader delivered to your home for $101.45 per year in Liberal, or $140 outside Liberal. Call 620-626-0840 for a subscription today. You can receive the print edition or an electronic edition! To subscribe today, email firstname.lastname@example.com.


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The Independent on Sunday: 'Bad bank' RBS plan will be rejected by Treasury
The Treasury is set to unveil its verdict on a break-up of Royal Bank of Scotland shortly after the Tory Party conference. A Government-commissioned report is expected to reject a full-scale split into a good and bad bank, but could recommend hiving off RBS's troubled Irish business in a bid to appease senior members of the Parliamentary Commission on Banking Standards who favour a break-up of RBS.
The Sunday Times: Brussels braces for bank chaos as ECB probes lenders
Brussels is preparing for a new wave of bank bailouts amid mounting fears that black holes in the eurozone's financial system are about to be exposed. The European Stability Mechanism, the £420bn rescue fund set up last year, is hiring investment banks to advise on potential rescues of lenders across the 17-nation currency bloc. It is also recruiting hundreds of staff, according to senior financiers.
The Mail on Sunday: BP to make millions from lifting of Iranian gas ban
A crucial North Sea gas field frozen by international sanctions against Iran is set to return to production following Government intervention aimed at lifting the ban. The Rhum gas field is jointly owned by BP and National Iranian Oil and once supplied five per cent of Britain's gas output. But the field has been idle for three years because of US and EU sanctions against Iran. The Government is understood to be close to agreeing a waiver for the field.
The Sunday Telegraph: Cabinet minister says 'Stop the clobbering of the rich'
Senior Conservative minister Chris Grayling, currently the Justice Secretary, warned that the tax policies of both Labour and Liberal Democrats will drive wealth creators out of Britain after the next election. He said that, in contrast, protecting "wealth and job creators" from tax rises is a "red line issue" for the Conservatives.Reuse content


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The Match Between Rajasthan Vs Odisha is like a match of in Hands of Odisha as if we look upon the Rajathan Previous Recods then From the Starting match of October 01 went Drawn, Match of October 08 was lost by Rajasthan by 152 Runs, The Match of October 15 went drawn, and so on Which made Rajasthan the most worst team of Ranji Trophy 2015 Whereas The Odisha Did well and Hopping for the Best From them. The Ranji had created many ups and downs this years.
Also Read: Mumbai vs Gujarat, Group B Ranji Trophy 2015 Prediction & Live Streaming
Rajasthan vs Odisha, Group A Ranji Trophy 01 December 2015 Tuesday Match Prediction
The Match Prediction Of Rajasthan vs Odisha, Group A is:
Rajasthan – 54%
Odisha – 46%
Also Read: Star Players to Join MS Dhoni For One-Dayers
Rajasthan vs Odisha, Group A Ranji Trophy 01 December 2015 Tuesday Live Streaming
The Match Will be Live Streamed Official By Star Sports
Hope You Like Our Match Articles Stay Tuned For More!!!


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Gun Control Debate Returnsto Statehouse
PROVIDENCE, R.I. (AP) — Hundreds of gun rights supporters have gathered at the Rhode Island Statehouse to oppose legislation prompted by the Newtown, Conn., school massacre that would ban semi-automatic weapons.
A House committee reviewed the proposal and several other gun-related bills Tuesday.
The semi-automatic weapons ban was proposed last year, following the 2012 Newtown shooting, but never got a vote.
Supporters including a coalition of religious leaders say the ban is a common-sense way of reducing gun violence.
But gun rights supporters like Frank Saccoccio say the proposal would infringe on Second Amendment rights and do little to address the problem of gun crime.
Lawmakers are also considering legislation to ban large-capacity magazines.
No votes on the measures have been scheduled.
Photo Credit:Shutterstock/Stephen B. Goodwin


text: Steve and Jill Cakebread founded The Cakebread Ranch in Star Valley, Wyoming in 2005. Their vision is to provide the highest quality guest experience in fly fishing and gourmet dining. The Cakebread Ranch produces premier food products from the organic farm and 100% full blooded Kobe beef from their Wagyu cattle. The ranch strives to be a model of sustainable ranching, farming and outdoor activities in Wyoming through restoration of habitats as well as providing ongoing educational programs for the community and for our guests. Please join Jill and Steve Cakebread at The Cakebread Ranch for a unique and memorable experience.Press Contact Chase Averill [m] 307.699.7578 [w] 307.883.2211 [e] email@example.com SOURCE The Cakebread Ranch


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Leader Sa PRO-ISIS Group Napatay Sa Sarangani
The Philippine National Police confirmed Thursday that the top leader of the pro-ISIS terror group Ansar al-Khilafah in the Philippines (AKP) is dead.
Based on initial reports from the PNP, an inter-agency force led by the National Intelligence Coordinating Council conducted an operation against Mohammad Jaafar Maguid at Angel Beach Resort in Barangay Kitagas, Kiamba, Sarangani province on Thursday.
According to the report, the operation "led to the death" of Mohammad Jaafar Maguid alyas "Tokboy." No further details were provided.
Also arrested during the operation were three of Maguid's supposed cohorts: Matahata Dialawe Arboleda, Ismael Sahak alias Mael and Morhaban Veloso alias Bugoy.
The AKP is a local terrorist group that pledged allegiance to foreign terrorist organization ISIS in 2015.
The PNP earlier tagged the AKP as the terror group behind the foiled Manila bombing last November 28.
PNP Chief Director General Ronald Dela Rosa had earlier announced that the planned bombing was the group's "audition" to receive validation from ISIS.
Results of police investigation revealed that the improvised explosive device (IED) was supposed to be detonated in Rizal Park initially before members of the terror group decided to bring it to Roxas Boulevard near the US Embassy.
Since the foiled attack, PNP has arrested four members of the group's alleged terror cell based in Bulacan who were allegedly behind the foiled attack: Mohammad Jumao-as, Rashid Kilala, Jiaher Guinar and Elmer Romero alias Jamal.
In December, the PNP also recovered a 2nd IED in Bulacan an artillery round with a 105mm projectile with a blast radius of about 75-80 meters. Authorities recovered the IED in Bulacan after getting information from one of the suspects they apprehended.
The AKP has links to the Abu Sayyaf, Maute Group and the BIFF.


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This triple light sconce by Norwell seamlessly blends superior form and function.More Details >
Let your bath area stand out with the refined look of the Jenna triple light fixture from Norwell. With its polished chrome finish offset by opal glass, it will perfectly accent your bath area decor. A hexagonal backplate rounds out the look. This fixture has been carefully crafted by Norwell artisans in their Massachusetts workshop.


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Oceania Cruises extends its OLife Advantage early booking incentive program. It's now available to all guests of the line who book Europe, Alaska or New England and Canada 2016 cruise before December 31, 2015.
OLife Advantage, which has been effective since yesterday, September 16, will reward all passengers, no matter what stateroom or suite category booked, with a wealth of complimentary amenities, including unlimited internet, pre-paid gratuities and free shore excursions, according to a statement from the line.
Additionally, any vacationer who booked after the program launched in July, but bought a lower category, non-qualifying room, will all receive Oceania's complimentary benefits.
Jason Montague, president & chief operating officer for Oceania, said that the response to the program from their passengers and travel agent partners had exceeded their expectations. Guests quickly understood the value OLife Advantage offers and the line decided to extend it to all accommodation categories for 2016 Europe, Alaska, New England and Canada trips.
OLife Advantage provides 3 free excursions on sailings up to 9 days, 4 free excursions on voyages between 10-13 days, and 5 free excursions on 14-day or more itineraries. Passengers will take advantage of free ship-wide Internet through the recently upgraded Wi-Fi system or at Oceania@Sea center.


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Discussion in 'Colorado Football Message Board' started by buffwoman526, Nov 28, 2008.
QB keeper with lil Hawk? :huh:
TD!!!!! F-in hell yeah!!
good start.
squib kick?
stupid squib.
Are the announcers going to cry? Sounds like they're terminally depressed after the Buff score on the 2nd play.
Nice stop!!
we've re-discovered the deep ball in the last two weeks
we're the greatest team EVER!
Great start! :woot:
Don't like the all-whites though.
Helll f-in yeah!!!!! 14-0 Buffs!!! Wooohoooooooooooo!!
wrap up and make a tackle, guys.
Looks like chat is only open to paying users. :huh: I've been busy and lazy, and haven't gotten around to signing up yet....
that's where i'm at. my paypal account is on a credit card i canceled and i don't feel like registering another right now.
Well, its was exciting for at least half a quarter. Same ol Cody is back.
there goes our chances, shi+
Just like that, tie game. :sad1:
Can these announcers ride the fusker's **** any more?
Where the **** was the interference call on the double reverse pass to DS????????????
You mean the pass that hit darrell in the #'s?:huh:
unbelievable that wasnt called...freaking defender totally turned him around
Holy hell what a first quarter!!!! :wow:
Nice no call on the 3rd down conversion on the sideline. He dropped the ball.
Our special teams, f-ing suck!!!! :sad2:
have to go for td, no FGs, Goodman, sux.
He actually made a FG. :wow:
Holy sh*t at that fake field goal attempt.
that was big...jimmy smith takes it to the house for the second straight year
No kidding!!! :wow: :dance:
That was stupid as hell! Holt was wide open on 3rd down and Ganz didn't see it. :sad2:
Worked against KU, but that's only something you do once in the season.
no matter what happens, that's about my favorite play ever.
Separate names with a comma.


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Making it to any GT Academy final is tough enough, but when you're competing in the newest region of the annual competition with a billion countrymen, it's a bit more special.
Following a two day trial in Jaipur, six finalists for GT Academy India have been selected to head to the gruelling Race Camp at Silverstone where they'll face 18 competitors from around the globe for that single Nismo Athlete prize.
Abhinav Bhat, Abhinay Bikkani, Prakash Nair, Akshay Gupta, Glen Ivan Suchita and Karl Patel came through from a 28-strong qualifier field in virtual and real racing tests, alongside fitness and media challenges to represent the planet's second most populous nation at Race Camp. Coached by Karun Chandhok, they'll have to beat finalists from Australia, Thailand, Mexico and the Middle East if they want to secure a racing career. With the six beating a bleep test at 44°C (111°F), the fitness should be little issue!
Showing them what their future could hold at Silverstone today was 2011 winner Jann Mardenborough. Taking a break from press activities at Goodwood and GT Academy, he was racing his Arden International GP3 car at the Silverstone Grand Prix support races and managed to secure both his best qualifying position (5th) and race position (9th, in race 1) of the season, to get off the mark and onto the points table.
Images courtesy Nismo Global.
Comments are now closed. Visit our forums for more discussion.
thank you so much guys! @famine, looking forward to seeing you there, and yes, I've seen the accomodation at silverstone, I'd choose outdoor showers over a palace any day! super humbled to have a shot at driving those amazing machines! :) will keep you guys posted!
Well done glen ivan hope you do well
Hey GTP! I am one of the fortunate 6 to have made it! I must say, Nissan outdid themselves, they put us up in a palace and the event was really special! All the journalists there were shell shocked! I'm just really thankful the Academy came to India! and I'm incredibly excited about silverstone!!! XD XD!!! Thank you GTP, the forums helped like crazy!!! :)
That's awesome, congratulations for all the finalists. I hope we brazilians can have our chance too. It should be so good make part of this selection. Good luck.
Congratulations to Glen Ivan and all of the other finalists. I wish you all the very best luck at Silverstone.
Congrats man and good luck!
Nice to hear from you Glen, please keep us posted. And best of luck to you!
Good luck to all the Indian finalists!!! Love to see broader international participation in the GTA.
I would have liked to participate in their Academy, like they do in ours. All I can figure out is that anyone that can participate in academyies outside of their region MUST be HACKERS and they should be BANNED.
I'm hoping that with the additions of newer countries like Canada and India into fold, we might have the opportunity of getting some new track locations… it's not like either country doesn't have any race tracks! Wishful thinking maybe, but I would welcome more diversity in that sense any day!
India is probably the least competitive country, but nonetheless, congrats!
Congratulations!! By the way I just remembered something? What happened to "the Drive of your life" slogan that gt used to have?
I thought was Peugeot's old slogan?
Slogans change some years.
That was used for GT4. Also, yes, it was the British Pug tagline.


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Canadian Pokémon fans hoping to get their hands on Pokémon Rumble U figurines are going to have a tough time catching them all.
Toronto game developer is creating a line of mobile games and accompanying toys for properties like Teenage Mutant Ninja Turtles and The Smurfs.
The move is part of a strategy to secure a piece of the growing market for completing real-world transactions with smartphones
Early Tuesday morning, Deloitte representatives will take the stage at the Sony Centre for Performing Arts in downtown Toronto to share 10 major trends they believe will shape the worlds of technology, media and telecommunications in 2012
Tech firms making news this morning: Apple Inc., Intel Corp. and ReadWriteWeb Media and SAY Media.
By launching a "digital wallet" pilot program Wednesday, Research In Motion Ltd. is hoping its BlackBerry devices will lead the world into a future in which a smartphone is all anyone will ever need to pay for groceries or open a locked door. Too bad the first profits will flow to wireless...
For widespread adoption of mobile payments to take place, Canadian consumers will need to be courted with incentives and discounts to change their behavior – to trade in the use of plastic credit cards, for the use of their ubiquitous smartphones
In the first step towards having BlackBerry smartphones take the place of physical wallets and security key cards, Research In Motion Ltd. announced a pilot project Wednesday that will see hundreds of Telefónica Digital employees use their BlackBerrys to make payments and access buildings
Tech firms making news this morning: Research In Motion Ltd., Apple Inc., Dell Inc., Sina Corp. and Amazon.com Inc.
It's not exactly the most ringing of endorsements, but Sameet Kanade with Northern Securities has bumped up his rating on RIM to speculative buy from sell while raising his target price to $26 from $18.
Karl Baldauf: Taken as a whole, proposed reforms will tip our economic balance in a profoundly negative way
The multi-billion dollar business is just as popular as ever with Canadian consumers and companies alike and any changes are quickly noticed
Students between grades 4 and 8 attended Go North, an event meant to 'ignite curiosity' for youth in the areas of science, technology, engineering and mathematics (STEM)
Vancouver-based Frank Giustra marks a return to the resource sector after a half-decade hiatus during the commodities downturn
Hundreds of times more petroleum runs into the oceans from storm drains on land than from tanker spills


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Gel Spice is recalling one lot of Fresh Finds Ground Turmeric Powder containing elevated lead levels.
No Illnesses have been reported to date in connection with this problem.
The recalled "Fresh Finds Ground Turmeric" is packaged in 3.75-oz. PET jars with a code of B/B 03/08/19 and B/B 05/18/19 on the neck of the container.
The product, which also has a UPC code of 81026-01230, was distributed at Big Lots stores throughout the U.S.
What to do
Customers who purchased the recalled product should discard it.
Consumers with questions about the recall may call (201) 564-0435.


text:
superbike kit Booster GB for Honda VFR 1200 F
- Description
ABM Superbike-Kit Booster GB
Handlebar change kit with complete triple clamp for mounting a conical 28.5 mm Booster handlebar tube (handlebar not included).
- Complete upper fork bridge with all necessary additions and alteration parts - only the handlebar must be ordered separately in the colour of your choice
- Please refer to the note in the Bike-DB as to which of the massive Booster link is provided for each model
- fairing or wheel do NOT usually have to be shortened - see note for each model in the Bike DB
- The handlebar makes the seating position much more comfortable
- Leads to a comparatively playful handling of the motorcycle
- The matching ABM Booster handlebar must be purchased separately in the colour of your choice
- In the Bike DB the recommended alternative 28,5 mm handlebar can also be used in the respective diameters - however the kit (cables etc) then may not fit and also changes in the fairing can be necessary!
Permit (in Germany):
With TÜV part certificate.
The tester (TÜV, Dekra, etc.) must certify the proper installation before use on public roads.
This test certificate must then be carried while driving, similar to the operating permit.
As soon as possible (that is, the next visit to the road traffic department for registration or change of address) this should be transferred into the registration documents.
Price per set
For our Swiss customers:
Please note, that due to the Swiss traffic regulation you'll need a valid allowance certificate which will be issued by our Swiss shop assistants and will NOT be delivered with the article.
- Shipping & delivery
We always give our best to handle your order as fast as possible. Orders which are placed before 2 pm on a work day are usually handed over to our logistics partner (DHL) on the same day if in stock.
Shipping cost
4.95 Euro within Germany, Poland
5.95 Euro in Austria, Belgium, Denmark, Luxembourg, Netherlands
9.95 Euro Spain, Finland, United Kingdom, Italy, Sweden
14.95 Euro Cyprus, Czech Republic, France, Greece, Hungary, Ireland, Portugal
19.95 Euro Estonia, Lithuania, Latvia, Malta, Slovenia, Slovakia, Romania, Bulgaria
All delivery costs are charged per order.
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Here you can ask public questions which can be answered not only by us, but also by other customers. If you have a private question, please use our contact form.
Fragen zum Produkt


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EVERY Saturday William Hill's Owen Scott and McBookie's Paul Petrie do battle in the junior football challenge.
The dynamic duo will be putting up trebles every weekend and Owen has the bragging rights having won £49 with Paul still to get off the mark. This weekend they've both pick massive trebles from the Scottish Junior Cup.
For those who don't know anything about junior football the level of the top clubs is equivalent or in some cases better than Scottish League 2 outfits and we can gauge that easier now with the champions of the three regions – North, East and West – qualifying to play in the William Hill Scottish Cup along with the Junior Cup winners.
The term "junior" has nothing to do with players' ages and it often confuses people outside Scotland. Some of the top clubs such as Auchinleck, Hurlford, Irvine Meadow and Linlithgow pay bigger wages than most League 1 and League 2 teams and therefore attract players who could be plying their trade at a higher level.
McBookie list all games online and take bets on every junior match while William Hill only take bets in shops.
Here are this weekend's tips from Paul and Owen.
Paul writes: "For many this is the best weekend of the junior season as most teams start their Scottish Cup campaigns. With 61 ties there should be enough games for punters to find a winner. And with Bo'ness 1-50 to beat East End there are plenty short-priced favourites to include in your accas.
I am looking at the more competitive games for my treble to try to find some value. Sadly a last-minute equaliser from St Anthony's beat my bet last weekend so hopefully I can have more luck.
First up I am backing Greenock to beat Bathgate at 11-8. Neither have played brilliantly this season but Greenock are more than capable of putting in a big performance and I always like backing West teams against their East counterparts when there isn't much between the teams.
Next I am going for Gartcairn to beat Hermes at 13-8. There is no doubt the Super League in the North has improved in recent years but this is definitely a tricky game for the North side. Gartcairn have adapted well to life in the juniors and will be eager for a good cup run. I can see them sneaking a tight game
Finally, I am taking a punt on Fraserburgh to beat Kinnoull at 11-4. As mentioned there is a big difference in class between the North and the other regions but Kinnoull aren't in the best form this season and won't fancy the long trip up to Fraseburgh. The home side of won most of their games so hopefully will take that confidence into the game and provide us with a big-priced winner.
Paul's treble
Treble pays £233 to a £10 stake at McBookie
Owen writes: "It's second-round day in the Scottish Junior Cup this weekend and William Hill have a coupon in their shops with all 61 matches on it. There are loads of long odds-on shots so while on paper this coupon looks easy you need to remember it's cup football so there will be some shocks.
I'm avoidngi all the short-priced teams and going for a massive draws treble. First up is Glenafton v Jeanfield at 10-3. Contrasting starts in the league as the Glens have struggled but Jeanfield have started well with their aim for promotion. I can see this being a tight match and playing again next week.
Muirkirk v Craigmark is a match between two of the minnows of the Ayrshire League in recent seasons but both have improved a bit this season and go into this match thinking they can book a spot in the third tound. I reckon it will end all square and they will play again next week. The draw pays 14-5.
Finally I'm taking the Renfrew v Maud match. These games are always difficult to price as the North Region sides always seem to struggle when they come up against other regions but Maud have started the season well and will be quietly confident of getting something when they visit Renfrew. A draw is 16-5.
Owen's Treble
Glenafton v Jeanfield draw
Muirkirk v Craigmark draw
Renfrew v Maud draw
Treble pays £700 to a £10 stake at William Hill
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What's going atop the roundabout?
Q: I am wondering as I go to and from work through the roundabout at Fourth & Bluemont, what monument might eventually sit atop the limestone base in its center. Any insight?
A: Not really.
As some of you might remember, Manhattan city commissioners killed a plan last year for a "wayfinder" sculpture in the new roundabout. That artwork, which included a sort of obelisk with female figures pointing in different directions, was proposed by the local Bowman architect firm and the Kent Bloomer art studio from Connecticut. Bloomer's outfit did
some of the work at the entry to the renovated Hale Library at K-State.
The cost of the proposed "wayfinder" sculpture is what appeared to kill the deal when commissioners shelved it in March, 2010. That price tag was estimated at $105,000; the whole round-about project was just north of $1 million.
Since then, well…
"It just kind of sits out there now," said assistant city manager Jason Hilgers. "Nothing's been proposed."
Part of the reason, of course, is that the city government hasn't exactly been in a spending mood for things generally perceived as frills. (I'm not judging whether public art is, in fact, a frill, but it would be safe to say that it's perceived as such.)
If private money could be raised to pay for something, the other question would be what should be put there. One suggestion informally floated, Hilgers confirmed, was a statue of Isaac Goodnow. He was one of the founders of Manhattan, and of K-State. He has been called "the father of public education in Kansas." But that idea never — or at least hasn't yet — achieved liftoff.
So, for the moment, it's just a roundabout. If you have an idea and you want to raise a hundred thou, charge right ahead.
You can submit a question to this column by e-mail to email@example.com, or by regular mail to Questions, P.O. Box 787, Manhattan, KS 66505.


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4 Photos Depicting MINECRAFT in Real Life
Look at this awesome depiction of Minecraft in real life done by Imgur user lebreum! Although the game has been a phenomenon since its release two years ago, I just recently got on board and saw what all the hype was about! I love these pictures and love the game.
Mick Joest —
I started out as a loyal reader of Geektyrant before emailing Joey one day about the potential of writing for Geektyrant. Now six years later I'm the managing editor of Gametyrant.com and still living the dream and giving my opinion to the geek masses! Geektyrant is my life, and I hope that shows in everything I do!
@G33kyMick // firstname.lastname@example.com
Featured Posts on GeekTyrant


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Illustration of stress.
I was honored to be requested as a contributer for the AW14 edition of the London based DASH Magazine
Cover Art for "Graceful Pandora". First single to be released in 7" format by Alone Records next October the 3th. Track included in the fothcoming Foscor's new album "Those Horrors Wither" 2014.
Foscor ( Dark Black Metal ) | www.foscor.com
Alone Records | The Stone Circle | 2014 | http://www.the-stone-circle.com
Here Pandora is depicted having opened Pandora's Box
but with the suffering exposed
she becomes able to identify and experience the good in contrast.
Centerfold Drawing for Lame'
Can a genre be dictated by a biological state, versus the content you create?
This is a piece to illuminate a truth, and to make aware the meaning of it's use as a reflection of our society.
- pen and ink, graphite -
- I live in Minnesota and the Winter is really taxing. I think its about time for spring cleaning -
- original illustration 22" X 30" -
Taken from the phrase "One Hundred Hours for Five Seconds" to demonstrate the labour in visual art and its reception.
Illustration done for German publication "Alle Meine Farben," with the theme of the power of Black and White
Caravaggio remix.
A calming homage to the end of the day.
Conceptual poster commissioned by film director Shridhar Reddy for his film "Lilith." Here are the two sisters depicted in the film's hell.
Illustration of the trauma suffered by an anonymous writer by the aggression of her father through verbal, physical, and emotional abuse.
A Happy little silly holiday card!
In this piece Nocturnal Emissions is a wall to wall decal that has been designed for a large hotel room. It is an erotic illustration to enhance the experience of a honey moon sweet.
This project is a magazine of an Illustrated and written reviews of Milan Fashion Week ss14.
Kyle Ahlm Kim & Mia Calderone
Welcome to Lame', a fully designed and illustrated observation of the faux riche. In these pages are written and shown the high-brow yearnings of our penniless lifestyle, as a communicative display to those able to empathize. Everything is inexpensive, but never cheap, as we create our polished universe from scrap, using recycled, on-sale, easily accessible materials and media. Lame' is the creation of upper class, but only on the surface.


text:
Internal strife deepens for Hollywood actors union
By Steve Gorman
LOS ANGELES (Reuters) - Union moderates fighting for control of the deeply splintered Screen Actors Guild moved again on Monday to oust hard-line contract negotiators they blame for stalled labor talks with Hollywood's major studios.
The move, likely to ratchet up tension within Hollywood's biggest union, took the form of a "written assent," a seldom-used procedure that enables a majority of SAG's national directors to take action outside the boardroom.
It came two weeks after SAG's moderate faction, known as Unite For Strength, was thwarted by the union's more militant leaders in a bid to remove executive director Doug Allen and the rest of his contract bargaining team during a contentious two-day board meeting.
There was no immediate comment from SAG leaders on whether they would accept the latest move or challenge it, but the Hollywood trade publication Daily Variety reported later in the day that Allen was stepping down.
It said he notified staff of his departure in an email that thanked them for their work.
Union moderates have accused Allen's allies on SAG's national governing board and SAG President Alan Rosenberg of resorting to "endless parliamentary games" to prevent an up-or-down vote during the January 12-13 session on a motion to oust him and the entire negotiating committee.
"This unprecedented level of obstruction has paralyzed the guild," the moderates said in a letter to SAG members.
The written assent called for firing Allen and replacing him as executive director with former SAG general counsel David White. Guild senior advisor John McGuire would be named to take Allen's place as chief negotiator. Continued...


text:
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text:
Oregon Health and Science University, Portland, OR
Correspondence to: Stephen M. Smith, FRACP, FJFICM, PhD, Division of Pulmonary and Critical Care Medicine, Biomedical Research Building (UHN-67), 3181 SW Sam Jackson Park Rd, Oregon Health and Science University, Portland OR 97239-3098; e-mail: email@example.com
Vanhorebeek and colleagues1recently addressed the controversies surrounding insulin treatment of hyperglycemia in the ICU. The authors reviewed single-center studies2–3 that demonstrated benefits of tight glucose control, and a multicenter study4 that showed no improvement with insulin use. Failure to achieve glucose targets was proposed to explain the negative multicenter findings.1 This plausible hypothesis begs the question: how did the single-center and multicenter studies compare in achieving target glucose? Vanhoorebeek and colleagues1stated that 70% of treated patients in the Leuven studies2–3 had mean daily blood glucose levels < 110 mg/dL, compared with a median glucose level of 118 mg/dL in the Glucontrol study.1The Leuven studies2–3 reported 6:00 am mean glucose levels, but if the mean daily blood glucose level was calculated from these values alone, meaningful comparison of glucose control in the different studies requires the assumptions that glucose does not vary with time of day and is distributed normally. We recently determined that these two assumptions are incorrect; in our ICU, glucose levels varied in an ultradian pattern, peaking twice every 24 h, and had a positively skewed distribution.,5 These new findings complicate the comparison of the reported data undermining the conclusion that failure to achieve target glucose levels underlies the failure of the multicenter study.1
For clinicians and investigators attempting to replicate the impressive results of the Leuven studies, it is essential to know what proportion of all glucose measurements were in range for patients receiving insulin in those studies because 6:00 am values are not representative of mean daily glucose levels.5 We agree with Vanhorbeek et al1 that achieving the glucose target range is crucial when investigating the efficacy of insulin infusion protocols, but the objective comparison of these studies requires that the glucose values achieved be clearly reported and include multiple time points.
The authors have no conflicts of interest to disclose.
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Adult Guntemperhairy Musesick 4 Da Streets [CD]
- Artist: El David
- Release Date: 12/12/2006
Best Buy is dedicated to always offering the best value to our customers. We will match the price, at the time of purchase, on a Price Match Guarantee product if you find the same item at a lower price at a Designated Major Online Retailer or at a local retail competitor's store.Here's how:
- If you find a qualifying lower price online, call 1-888-BEST BUY and direct a customer service agent to the web site with the lower price, or when visiting a Best Buy store, one of our employees will assist you.
- On qualifying products, Best Buy will then verify the current price to complete the price match.
Exclusions apply including, but not limited to, Competitors' service prices, special daily or hourly sales, and items for sale Thanksgiving Day through the Monday after Thanksgiving. See the list of Designated Major Online Retailers and full details.
- Adult Guntemperhairy Musesick Intro
- Libertad
- Where We Live
- Freedom
- Power to the People
- Boricua
- Palante
- Puppet
- Juntos Luchamos
- Hands off O' Cuba
- Does Anybody Hear You
- Amor Eterno
- Them Slow
- I'll Kill 4 You
- Bush Man & Ladin
- I Don't Rap 4 Dead Presidents
- Dear Santa
- Who the Funk Stole Your Soul
- State of Emergency