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Hot Summer Special!!! Luxury 5bd/4.5bth- Walk to Town & Slopes(29 Reviews)
The owner has been emailed.
To book this property, you need to complete your booking through checkout on the VRBO website. We can't protect your payment if we don't know you've booked through us. Learn more
- Minimum stay:1-8 nights
- Sleeps:14
- Bedrooms:5
- Bathrooms:4.5
- Property type:House
- Internet:Yes
- Pets considered:No
- Wheel chair accessible:N/A
About the Property
House, 5 Bedrooms, 4.5 Baths (Sleeps 14)
This newly remodeled resort home is a rare find. Ideal for large groups and families – Sleeps 14. Within half a block to town lift and one block to the heart of Park City village, you can also walk to the library, the kids' city park, skateboard park and more while winding down in comfortable luxury.
Don't feel like walking a few blocks? The bus to all other resorts and surrounding Park City towns picks up two blocks away.
This beautifully appointed, luxury 3400 sq. ft. home offers a 5 bedroom, 4.5 bath layout with 2 distinct living areas (upstairs and downstairs), a gourmet kitchen, a loaded, professional grade game room, 7 person hot tub and stone fireplace.
Plus, easy parking for 3 cars (garage, driveway and address specific reserved parking).
Detailed Home layout (sleeps 14 easily): Detailed Home layout (sleeps 14 easily - in beds - no pullout couches).
Entry floor – Designed as a massive open space area including
** Custom Great Room: stone fireplace and custom cabinetry bookshelves, sitting areas with large, comfy leather couches and recliners, large, flat screen plasma TV, bar seating, separate writer's desk work station.
** Gourmet Kitchen, stainless steel gas stove, hand painted custom tile work, floor to ceiling custom cabinetry and full pantry.
** Dining Room - open, window-backed (seating 10-14), mountain view, extend-able table 5ft, 7 ft, 9ft, custom leather cushion built in benches.
** A half bathroom with marble terrine counter mounted sink, easy hot tub access, handcrafted tile work.
** Master Bedroom (King) large, flat screen TV, master bath walk in shower (multiple shower heads and bench), Jacuzzi (110 jet) bath, dual sinks, bidet.
Upstairs / 2nd floor – 2 bedrooms and 2 full baths.
** The Second Master (King): flat screen TV, en Suite Full Bath with shower, bath, dual sinks.
** Queen Room with dedicated, full bath adjacent.
Lower Floor - Gameroom, Queen Bedroom, Bunk Room and Full Bath.
** Massive Game room: wet bar, professional shuffle board table, professional pool table, 50' flat screen TV, leather couch and bar seating.
** Bunk room (Sleeps 6-7): two full/full bunk beds, one twin/twin bunk with trundle, custom closet.
** Queen bedroom: dresser alcove, flat screen TV.
** Full bath with dual sinks, tub and shower.
** Laundry room.
Throughout the Home:
** State of the Art Multi Zone Sound System: wired throughout the home, remote-control, house-wide and en suite selections, Internet music subscription, iPod docking stations, 5 plasma flat screen TVs, 2 surround sound systems.
** Wi-Fi
** Luxury Designer Furnishing and Finishes: new furnishing, bedding and linens, custom cabinetry closets, book shelves and wood working, above counter copper and marble vessel (basin) sinks, radiant heat throughout the home.
Outside - Garage/Backyard
**Mud Room and Garage: heated garage and code access to garage
** Recreational Backyard, 7 person hot tub, fenced in deck and landscaping
Need an airport pickup? Around town transportation? Stocked kitchen? Discounted rental gear? Babysitting? We have you covered! Transportation and concierge services available upon request.
When you're ready to book, here are some tips to keep in mind.
Paying with a credit card on VRBO protects your payment for up to $10,000 against listing fraud. We recommend completing your booking on VRBO.Learn more
Member since: 2009
Property Type
- House
- 3500 sq. ft.
House Rules
- Max. occupancy 14
- Non Smoking Only
- Pets Not Allowed
Accommodation Type
- Vacation Rental
- Guests Provide Their Own Meals
Bedrooms: 5 Bedrooms, Sleeps 14, Beds for 14
Bathrooms: 4 Bathrooms, 1 Half Bathroom
Other Amenities
- Books
- Books For Adults
- CD Player
- DVD Player
- Game Room
- Games
- Music Library
- Pool Table
- Satellite / Cable
- Stereo
- Television
- Video Library
- Autumn Foliage
- Botanical Garden
- Cinemas
- Forests
- Health/Beauty Spa
- Library
- Live Theater
- Museums
- Playground
- Pond
- Recreation Center
- Restaurants
- Theme Parks
- Waterfalls
- Winery Tours
- Zoo
Local Services & Businesses
- ATM/Bank
- Babysitter
- Fitness Center
- Groceries
- Massage Therapist
- Medical Services
Leisure Activities
- Antiquing
- Bird Watching
- Boating
- Eco Tourism
- Horseback Riding
- Horseshoes
- Miniature Golf
- Outlet Shopping
- Paddle Boating
- Scenic Drives
- Shopping
- Shuffleboard
- Sight Seeing
- Sledding
- Walking
- Wildlife Viewing
Location Type
- Mountain
- Mountain View
- Town
Sports & Adventure Activities
- Basketball Court
- Cross Country Skiing
- Cycling
- Equestrian Events
- Fishing
- Golf
- Hiking
- Hot Air Ballooning
- Hunting
- Ice Skating
- Jet Skiing
- Kayaking
- Mountain Biking
- Mountain Climbing
- Mountaineering
- Paragliding
- Parasailing
- Racquetball
- Rafting
- Rock Climbing
- Sailing
- Ski Lift Privileges
- Skiing
- Snowboarding
- Snowmobiling
- Swimming
- Tennis
- Water Skiing
- Water Tubing
- Whitewater Rafting
- Wind-Surfing
- Dining
- Dining Room
- Seating for 14 people
- Activities Guide
- Alarm Clock
- Basic Soaps
- Broadband Access
- Ceiling Fans
- Clothes Dryer
- Computer Available
- Covered Parking
- Filtered Water
- Fireplace
- Garage
- Gas Fireplace
- Hair Dryer
- Heating
- Internet
- Laundry Soap
- Linens Provided
- Living Room
- Local Activities Guide
- Local Maps
- Local Restaurant Guide
- Paper Towels
- Parking
- Parking On Street
- Shampoo
- Telephone
- Tiled Stove
- Toilet Paper
- Towels Provided
- Washing Machine
- Water Cooler
- Wireless Internet
- 4 Ring Stove
- Blender
- Coffee Grinder
- Coffee Maker
- Cooking Utensils
- Dishes & Utensils
- Dishwasher
- Freezer
- Grill
- Ice Maker
- Kitchen
- Microwave
- Oven
- Pantry Items
- Refrigerator
- Stove
- Stove
- Toaster
- Balcony
- Barbecue
- Deck / Patio
- Outdoor Grill
- Outdoor Grill Gas
- Wood Deck
Pool / Spa
- Hot Tub
- Outdoor Hot Tub
- Jetted Tub
RatesCurrency Conversion
|Weekend Night
|Monthly *
Spring Value
Apr 17 - Jun 18, 2017
2 night min stay
Jun 19 - Jun 30, 2017
3 night min stay
Fri, Sat
Jul 1 - Jul 8, 2017
4 night min stay
Jul 9 - Aug 31, 2017
4 night min stay
Fri, Sat
Labor Day Weekend
Sep 1 - Sep 3, 2017
3 night min stay
Sep 4 - Nov 16, 2017
3 night min stay
Early Ski
Nov 17 - Dec 18, 2017
4 night min stay
Dec 19 - Jan 3, 2018
6 night min stay
Value Ski
Jan 4 - Jan 17, 2018
5 night min stay
Sundance Film Festival
Jan 18 - Jan 28, 2018
8 night min stay
Value Ski
Jan 29 - Feb 15, 2018
5 night min stay
President's Week
Feb 16 - Feb 24, 2018
5 night min stay
Peak Ski
Feb 25 - Mar 31, 2018
5 night min stay
Late Ski
Apr 1 - Apr 14, 2018
4 night min stay
Spring Value
Apr 15 - Jun 16, 2018
3 night min stay
Jun 17 - Jul 1, 2018
4 night min stay
Fri, Sat
Additional information about rental rates
Fees and Rental Conditions:
- Property Damage Protection $59
- Cleaning $300
- Tax Rate 10.45%
Our cancellation policy is that 80% of your prepay deposit can be returned for cancellations within 100 days of the reservation. Up until 75 days prior to reservation, 50% of the deposit will be returned. Up until 45 days prior, 20% of the deposit would be returned. Up until 30 days, 40% of the total deposit (so at that point it's 40% of the rental payment) would be returned. After 30 days there is no returned payment. At any cancellation time, the security deposit will be returned in full.
Owner's cancellation policy:
100% refund for cancellations more than 60 days before check-in date.
Don't forget your vacation protection! Get protected now
Adding our Vacation Protection services can make sure your getaway goes smoothly, no matter what. We offer Cancellation Protection and Damage Protection so you can truly relax.
Car: Not Necessary
This newly remodeled resort home is a rare find. Ideal for large groups and families – SLEEPS 14. Within HALF A BLOCK TO TOWN LIFT and ONE BLOCK TO THE HEART OF Park City village, you can also walk to the library, the city kids' park, skateboard park and more while winding down in comfortable luxury. Don't feel like walking a few blocks? The bus to all other resorts and surrounding Park City towns picks up two blocks away.
This beautifully appointed, luxury 3400 sq. ft. home offers a 5 bedroom, 4.5 bath layout with 2 distinct living areas (upstairs and downstairs), a gourmet kitchen, a loaded - professional grade - game room, 7 person hot tub and stone fireplace.
Plus, easy parking for 3 cars (garage, driveway and address specific reserved parking).
Home Highlights:
Massive Game Room
Luxury Kitchen
New, luxury furnishings
State of the art electronic and media systems
Large Hot Tub
High comfort/ease Mud Room
Hardwood floors
Other Activities: Shopping, Kayaking, Boating, Parasailing, Snowboarding, Snowmobiling,Health/Beauty Spa, Racquetball, Basketball Court, Horseshoes, Mini Golf
Golf: Blocks to the Park City Golf Course
Ski: Half a block to the town lift. 4 blocks to the Park City main resort base. Bus stop in front to Deer Valley and Canyons resorts. Excellent location!!
Owner info
Year Purchased: 2010
About the owner: PLEASE CALL ME DIRECTLY TO CONFIRM ALL BOOKINGS. PHONE NUMBER IS ON THIS LISTING. We fell in love with Park City because of it's easy, active lifestyle and breath-taking location. With SLC airport a predictable 35 minutes away and a first class local transportation system, you can leave traffic and hassles behind to explore three luxury resorts and months worth of restaurants from your front door.
Why the Owner Chose Old Town, Park City, UT, USA:
PLEASE CALL ME DIRECTLY TO CONFIRM ALL BOOKINGS. PHONE NUMBER IS ON THIS LISTING. Nothing recharges like Park City mountain time. Regardless the season, the mountains offer plenty of outdoor adventure, the colorful, quaint town is easy to access and the entire area is full of good eats, treats and nightlife. With the predictable 40 minute drive from SLC airport and tremendous weather/ snow Park City guarantees a stress free vacation. In addition, Park City is surrounded by world class resorts and adventures - Deer Valley, The Canyons, Snowbird and Alta for snow, Moab desert getaways and more.
Contact us
Send email
- Primary: +1 3104800696
Links to more information:
- Click Here to see All My Rental Listings
Welcome home!
This listing was first published here in 2010.
Date last modified - Saturday, May 27, 2017
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Possibly the World's Best Coffee and some of the best Cowboy Music in the West!
All coffee roasted on site and brewed by the cup just for you
in an atmosphere that honors the heroes of the West!
238 E Caldwell Ave
Visalia Ca 93277
238 E Caldwell Ave,
Visalia, CA 93277
Monday: 5:30am-3:00pm
Tuesday: 5:30am-3:00pm
Wednesday: 5:30am-3:00pm
Thursday: 5:30am-3:00pm
Friday: 5:30am-3:00pm
Saturday: 6:00am-3:00pm
Sunday: Closed
Phone: 559-747-2824

subset: commoncrawl


text: TORRANCE, Calif., Nov. 18, 2013 /PRNewswire/ -- The 377-horsepower Acura RLX Sport Hybrid SH-AWD luxury-performance sedan will be on public display for the first time tomorrow at the Los Angeles International Auto Show, showcasing Acura's dynamic new three-motor hybrid system. (Photo: http://photos.prnewswire.com/prnh/20131118/LA19670) (Logo: http://photos.prnewswire.com/prnh/20100923/ACURALOGO) The 2014 Acura RLX Sport Hybrid SH-AWD, which launches next spring, is the first vehicle to deploy Acura's new three-motor hybrid powertrain technology. The system combines a highly efficient, direct-injected V-6 engine with an all-new, Acura-designed, 7-speed dual clutch transmission with built-in electric motor and an electrically powered variant of Acura's highly regarded torque-vectoring Super Handling All-Wheel Drive (SH-AWD). This advanced new hybrid powertrain delivers exhilarating driving performance with incredibly responsive power delivery and precise, sure-footed handling performance like no other vehicle in its class. Supported by the instantaneous torque delivered by its high-output electric motors, the RLX Sport Hybrid runs a 0-60 mph time comparable with competitor's V8-powered machines. This performance, however, is coupled with a 28/32/30mpg (city/highway/combined) EPA fuel economy rating 1, which is in the range of 4-cylinder-powered luxury sedans. Powertrain and DrivetrainThe RLX Sport Hybrid's 3.5-liter, 310-horsepower, i-VTEC ® V-6 engine with Variable Cylinder Management™ (VCM™) includes an idle-stop feature to help maximize fuel efficiency. The engine is mated to an all-new, 7-speed dual clutch transmission with built-in electric motor. In automatic mode, the transmission provides highly responsive and intuitive gear selection, including matching engine revs during downshifts, in manual mode, the Sequential SportShift paddle shifters give the driver gear selection control to make virtually seamless ratio changes. The electric SH-AWD system on the RLX Sport Hybrid eliminates the conventional drive shaft and rear differential, replacing them with two high-output 27-kilowatt electric motors. The rear motors dynamically distribute both positive (drive) and negative (regenerative braking) electric-motor torque, depending on driving conditions, and which torque vectoring assists in cornering. The system is further aided by a 35-kilowatt front electric motor that supplements engine torque to the front wheels and provides regenerative brake torque to charge the vehicle's 260-volt lithium-ion battery pack.


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Assembly tools
Quality assurance in tightening
Data analyzers (Quality assurance in tightening)
Portable ST analyzer for checking tool performance, repeatability and accuracy
Request information [-]
8059 0955 60
Compressors and Generators
+254 20 6605000
Send an email
In assembly operations worldwide there is an increasing focus on quality. Using sophisticated tools to tighten bolts is simply not enough. It's also important to monitor tool performance, and to test joints after they have been tightened. This is where the Atlas Copco STanalyser comes in. The portable STanalyser can be used to check tool performance, repeatability and accuracy for all types of power tools and torque wrenches. Test your tools in the tool crib following service and continuously on the line to monitor performance or test your joint by checking the residual torque using our unique residual torque check function.
Legal Notice, Privacy Policy, Copyright © 2000-2014 Atlas Copco Eastern Africa Ltd. All rights reserved.


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If I had a dollar for every person that said that they don't use coupons because they can't get coupons for natural, organic and healthy foods I would have a lot of money.
Not only can you get coupons for natural and organic foods, there is a whole website dedicated to providing coupons for these healthy foods.
The Healthy Shopper offers a coupon book that enables consumers to buy high quality natural and organic foods at affordable prices. It was founded in 1999, to encourage Canadians to pursue and maintain a naturally healthy lifestyle.
The Healthy Shopper has recently published a book "Unjunk Your Junk Food," dedicated to finding healthier alternatives for our favourite junk food. An excellent book for anyone looking for a healthier diet.
I was amazed at the healthier options available on the market although some of the items in the book I had never heard or seen yet in Canada.
The Healthy shopper has chosen five natural products that they've tested and found worthy of sharing with Canadian women.
The Healthy Shopper Picks for Spring 2012.
Earth Balance, producer of an award winning line of buttery spreads, sticks, shortening, a soy-free spread and coconut spread, all delicious alternatives to butter and margarine.
I'm not a big fan of butter or margarine so I don't generally use much of these types of spreads. However Earth Balance products are plant-based, vegan, made without artificial ingredients or hydrogenated oils, are dairy and cholesterol-free and free of gluten, lactose and eggs. offering delicious options for people with food sensitivities or those who are seeking healthier alternatives to everyday staples. www.earthbalancenatural.com. It tastes pretty good too.
Ecover's award-winning, high performance Ecological cleaning products.
As cynical as it might sound, I generally don't like eco-friendly cleaning products because they don't seem to clean as well but Ecover really worked for me. Grant you I had less bubbles but it was mild and ideal for washing my newborns clothes. These natural dishwashing liquids, dishwasher tablets and laundry detergents are effective, powerful and are ideal for sensitive skin. They are phosphate-free and completely bio-degradable, safe for septic tanks and not tested on animals. www.ecover.com/ca/en
Simply Natural made by Chelten House – organic sauces that are fresh and rich. All Chelten House's pasta sauces are certified organic by Quality Assurance International (QAI) and USDA Organic.
Since I frequently make my own tomato sauce it is hard to compare the taste and quality of my homemade sauce with the ones on the market but Simply Natural contains fresh organic vegetables and herbs that make the sauce rich and tasty. All the ingredients are grown and processed without hormones, pesticides, herbicides, and chemical fertilizers, insecticides, genetic manipulation or antibacterial radiation. www.cheltenhouse.com/content.cfm?mode=sn_products. It is definitely a much better option without all the sodium we find in traditional pasta sauces.
Natracare feminine hygiene products: Feminine hygiene products that are 100% organic and chemically-free.
Most ladies use feminine hygiene products regularly so it only makes sense to use a feminine product that is certified 100% organic and chemical free. I can see why Natracare feminine hygiene products would be on the list of the top 5 Healthy Shopper Picks for Spring 2012. They are 100% plastic-free and free of chlorine as well as being bio-degradable and compostable. In fact, Natracare's tampons were the world's first fully certified organic cotton tampon. Before Natracare, all menstrual tampons were made from chlorine bleached rayon and blends of rayon and conventionally grown cotton. www.natracare.com Another major advantage is the price point. For the quality you receive they are also inexpensive!
Kiju 100% certified organic juices: Made from organically grown fruit.
Once again I don't generally buy juice because of all the sugar that gets added to fruit juice however Kiju was Canada's first certified organic juice box without any added sugar. Its fruit juice flavours include mango orange, lemonade, grape apple, apple and pomegranate cherry that satisfy all taste buds. I had the opportunity to try the majority of their flavours and loved them all. This year Kiju launched their new organic iced teas in Pomegranate Green Tea, Mango Passion Maté, and Hibiscus Rooibos flavours. www.kiju.ca and once again their iced teas were refreshing, not too sweet but sweet enough to taste the fruit flavours.
Now the giveaway, co-founders Randy Boyer and Andrea Donsky of the healthy shoppers coupon book have have generously offered to giveaway a gift basket to one lucky winner to help promote their top 5 healthy shoppers picks for Spring 2012. One winner will be randomly selected on May 8th 2012 and will receive a copy of the new book Unjunk Your Junk Food, along with the list of the Healthy Shopper Picks for Spring 2012 containing:


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Originally posted on Fox Sports Florida | Last updated 10/23/12
MIAMI Ozzie Guillen knew it could be coming. On Tuesday, it did. Guillen was fired after just one season as manager of the Miami Marlins. It was a season that started with Guillen telling Time magazine I love Fidel Castro, and one that ended with the Marlins finishing in last place in the NL East at 69-93. After careful consideration following the disappointment of the 2012 season, we decided to dismiss Ozzie, Marlins president of baseball operations Larry Beinfest said in a statement. Our managerial search begins immediately and our hope is that a new manager, along with roster improvements, will restore a winning culture. During the waning days of the season, Guillen said he was hopeful he would return as manager. But he was aware of the possibility he could be fired despite having three years left on his contract. "Why?" Guillen said. "Look at yourself in the mirror and say why. You're in last place. But Guillens comments about Castro might have caused just as much damage. Many Cuban-Americans in Miami were outraged, and Guillen received a five-game suspension. The Marlins will be looking for their fifth manager in three seasons. Since 2010, theyve had Fredi Gonzalez, Edwin Rodriquez, Jack McKeon and Guillen. Guillen, who will be owed about 7.5 million for the final three years on his contract, has a nine-year managerial record of 678-617. He was manager the previous eight seasons for the Chicago White Sox, winning the World Series in 2005.
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We have not yet reviewed this particular year. You can sign up to receive email updates any time we learn anything new on the Lexus IS 250C.
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Find out what audit means to you
The latest tax tools and resources
Becoming a digitally mature enterprise
A technical forum for risk professionals in the banking secto
What does the future look like for digital technology in the public sector?
Engaging the future luxury consumer
#DiscoverYourself – A new perspective can change everything
Winning over the next generation of leaders
For tertiary education in professional services
There is a global tax reset underway. Initiatives like the OECD/G20 Base Erosion and Profit Shifting (BEPS) project will fundamentally change the global tax landscape. Already, tax has become a significant strategic business issue. These pages will help businesses navigate this new environment.
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With consulting, technology and outsourcing experience, Deloitte TMC helps businesses meet the challenges of multi-jurisdictional tax operations, including compliance, reporting and risk management for direct and indirect taxes.
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Posted by Shar VanBoskirk on November 23, 2009
Posted by Shar VanBoskirk and Sarah Rotman Epps]
Posted by Shar VanBoskirk on November 11, 2009
I dedicate this blog post to anyone who has read Forrester's interactive marketing forecast and thought, "well that's great, but how are interactive marketers in *my* industry spending on interactive tools." I've just published the US Interactive Marketing Forecast By Industry, 2009 to 2014 which splices our interactive marketing forecast by 12 different industries including:
Posted by Shar VanBoskirk on November 5, 2009
Last night Microsoft launched a new look and feel for msn.com to a limited number of consumers. The new design will roll out to the mainstream in January.
Forrester got a sneak peak of the new-and-improved interface in October.
Posted by Sarah Rotman Epps on November 3, 2009
You may have seen the news about Marvell Technology Group, a chip-maker, integrating its chips into E Ink's display modules. This sounds very tech-y, but it has real consequences for the consumer experience of eReaders. Namely:


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All are welcome at our Sunday morning service! Our service begins at 10:30AM, where we gather together to worship God, connect with each other, and have a coffee (or two!).
Harmony Baptist Church is dedicated to children and families. We offer many inclusive programs that help the family flourish. Click here to visit our family programs page.
Harmony Baptist Church has ran Boomerang Camp for over 7 years! Hundreds of kids have come and experienced the fun of Boomerang Camp.Click here for Boomerang's website!


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A family home: convenient, comfy, and designed for the whole family
Our home is located just a few blocks (walking distance) from the heart of Victorian Bellefonte. Close to charming Victorian mansions, local restaurants, coffee shops, a quaint park and newly finished riverwalk. One can enjoy the small town feel or drive just 15 minutes to Penn State University for sports events or entertainment. There are four state parks within a 30 minute drive for boating, swimming, fishing or hiking in the Pennsylvania mountains.
To organize a home exchange, you need to be a member


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Michael Luvaglio, now 63, and Dennis Stafford, 57, were jailed for life in 1967 for the murder of playboy money collector Angus Sibbett who was shot dead and dumped in the back of his car on the outskirts of Newcastle.
The pair have always protested their innocence. However, despite glaring inconsistencies in the case against them, all their previous appeals have failed. Lawyers believe it represents one of the most serious miscarriages of justice of the past four decades and that if the men were tried with the same evidence today, they would be acquitted.
Luvaglio told The Observer: 'I did not kill Angus. He was my best friend, he was like a brother to me and I have never hurt anyone in my life. But in the the eyes of the law I am a convicted murderer on a life licence.'
Luvaglio, Stafford and Sibbett had all moved from London to Newcastle in the mid-Sixties to work for Luvaglio's older brother, Vince, who was making a fortune supplying fruit machines to pubs and clubs.
They were part of a migration of Londoners who cashed in on the Newcastle scene and became wealthy in the process, occasionally fighting off competition - including the Kray twins. Sibbett, who was employed to empty the machines, supplemented his income by skimming the takings. He lived a colourful life, driving a brand new Jaguar and socialising with celebrity friends including the young Tom Jones.
His murder provided the basis for the novel Jack's Return Home by Ted Lewis which follows London gangster Jack Carter as he travels to Newcastle to avenge the murder of his brother. It was turned into the hit film Get Carter, starring Michael Caine.
Sibbett was last seen leaving his home on 5 January at 11.15pm and was found dead in his car at 5.30am. He had been shot in the body at least three times while sitting behind the wheel and his body was then folded up and dumped in the back of the vehicle. The car appeared to have crashed shortly before he was killed.
Luvaglio and Stafford, who spent the evening together, had cast-iron alibis, barring 45 missing minutes before 12.30am. Police said they had followed Sibbett's car to a remote area, crashed into him, shot him and then taken his car and body back to South Hetton, Co Durham, where it was eventually found. Supposedly, they then raced off to Newcastle, arriving at the Birdcage Club at half past midnight in Stafford's 'E' Type Jaguar. No motive was ever put forward and no forensic evidence linking the two men to the killing was ever found.
An investigation by The Observer has revealed a number of other inconsistencies in the case against them.
At the time South Hetton was the site of a coal mine, and at least 40 miners reported walking past the vehicle between midnight and 2am on their way to and from work.
A number stopped to examine the vehicle more closely, intrigued by the sight of such a flash car in such a run-down area. None reported any damage to the bodywork or windows or the presence of a body in the back. None of their statements were ever given to the defence or heard by the jury.
Another witness recalled pulling up behind the car at 12.37am and seeing an arm appear out of the driver's window waving him past. According to the police, Sibbett was dead at this time and Stafford and Luvaglio were back in Newcastle - but the jury heard none of this.
In all, 164 statements which undermined or contradicted the prosecution case were not disclosed to the defence until after the trial.
A key part of the prosecution case was the fact that Stafford's car had been damaged in a crash. Police organised a reconstruction showing that this had been caused by a collision with Sibbett's vehicle but new documentation obtained by The Observer shows that the reconstruction took place on the brow of a hill where the vehicles lined up in an unnatural way.
Blood was found on the inside of Sibbett's car which matched that of neither the murder victim nor Stafford and Luvaglio. Traces of Sibbett's blood were also found in a nearby phone box, something which has never been explained. The judge was also strongly criticised for his summing-up of the trial during which he likened Luvaglio to 'Judas or Brutus' because of the alleged betrayal and murder of his friend.
Both men served 12 years before being released on licence. During numerous appeals there was outrage expressed over the lack of disclosure which led directly to new laws to prevent the same thing happening again, but judge after judge and even the House of Lords refused to quash the convictions.
'This all took place in a time when the safeguards we have in place did not exist,' says Luvaglio's lawyer, Christopher Murray of Kingsley Napley. 'This case dates back to a time before the introduction of the Police and Criminal Evidence Act, before there were rules governing the disclosure, and when the Court of Appeal was very reluctant to admit that the criminal justice system could make mistakes.
'I have no doubt that if this case were presented for appeal today, the conviction would not stand, it would be declared a miscarriage of justice.'
Although Luvaglio had no criminal record at the time of his arrest for the murder, Stafford was a notorious underworld figure. Luvaglio believes the police were simply targeting Stafford and that he got in the way.
During his police interviews, which were not recorded and of which no written record was made, Luvaglio was urged to save himself by passing the blame.
'They told me that if I said Stafford had gone off, I would be allowed to go free. But if I insisted on saying that Stafford was with me between those times, I would be charged with murder as well. They were urging me to say that he had gone off on his own for an hour or so but it simply wasn't true.' The officer in charge of the case at the time, Superintendent Raymond Kell, now denies making such an offer.
Luvaglio was last week filmed travelling to Newcastle to visit Sibbett's grave as part of a BBC documentary which is also highlighting his case. 'I am not a killer, and I don't want to end my days with that hanging over me.'


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{estoy tomando clases de inglés en una iglesia porque la escuela ya no tenía salones. Me encontré esto. Hay mucha gente ahí afuera que no es religiosa, pero creo que incluso si no crees hay algo que es muy importante que todos recordemos: ser bueno, ser amables, perdonar, amar, y vivir. Todos formamos parte del mismo espacio, e incluso si no quieres que te lo diga una iglesia, a veces es simplemente bueno que te lo recuerden, porque lo olvidamos, no importa de quién venga}
Today, remember Jesus. Remember to speak up for those who don't have a voice.
Be kind to everyone. Today, be last. Really<<< Put others ahead of yourself.<<<
<<<Jesus did not come to be served. But to serve.
Don't worry about your clothes or anything like that. god is looking out for you and will provide all that you need.
Tomorrow... tomorrow can and will take care of itself.
Today is the day to live for God.
Remember that you have a father in heaven who wants to lavish love on you.
Ask. Open your eyes and watch what He does.
Live today with a pure heart. You will see God.
Today, put your faith in the One who calms storms.
Give your life
to the One who heals the sick and takes away the sins of the world.
Remember what He said about camels and needles.
Sometimes money really can cause more problems than it's worth.
If you want mercy, you need to show mercy.
Build people up<<<
with a kind or gracious gesture.
When you do good things for people... hide it from others.
Do good in secret, and you'll have a great reward.
<<<Forgive. Forgive everyone.
Let Him have your load. You weren't mean to carry it all by yourself. There is rest.
Don't forget: a little bread and fish will go a long way in the right hands.
Be Jesus to everyone you meet.
Love God. Love Others. Live the Gospel.
Today will be different.
Current Location: wild
Current Mood: calm
Current Music: M83 -Midnight City


text: Being a hard worker is cool and all, but to be a good employee, you just need people to think that you're a good employee. Bully weaker co-workers during boardroom meetings by responding to all of their points with, "My only concern is…" followed by something not at all concerning. Also, mark half of your outgoing emails as "urgent" and always keep an application open on your computer. Follow these simple steps and you'll have a corner office and stock options by October.


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GEO is one of the United Kingdom's fastest growing independent online Garage Equipment supply, delivery and installation Companies.
All of the vehicle servicing equipment supplied by Garage Equipment Online is CE certified and fully conforms to all UK and European safety regulations, the whole range of garage workshop equipment sold by our company comes backed up with a full two year parts warranty and industry beating after-sales care.
Here at Garage Equipment Online we use a single, ultra-reliable company that operates nationwide for the servicing and installation of our garage equipment this provides us with a level of accountability and control as we have a single point of contact with a tried and tested business that fully satisfies the high standards of customer care set by our company.
Garage Equipment Online have in stock a comprehensive range of garage equipment replacement parts that can be dispatched direct to your place of business at a moments notice, with all that your business will ever need to keep your Garage working with a minimum of fuss, there really is reason why you should not Choose GEO for the purchasing of your brand new garage equipment.
Garage Equipment Online can ship your brand new garage equipment direct to your place of business whether you are located in the UK or worldwide, With next day garage equipment delivery available to most UK destinations and worldwide shipping usually within 14 Days.(Extra fees apply for next day option)
We like to think of ourselves as the new garage equipment supply company with the old fashioned values so you can rest assured that when you buy your garage equipment from us you are not only purchasing a piece of high quality garage equipment but also buying into an ideology where customer satisfaction is key and after sales care means just that.
Our goal here at Garage Equipment Online is to create sustainable business relationships that are built on trust and integrity as we are aiming to achieve and maintain outstanding repeat customer rates and industry recommendations.
Garage Equipment Online are primarily suppliers of quality Garage Equipment however if you are unsure as to how to correctly install your new Garage Equipment we can either pre-assemble your purchases for you at our warehouse prior to shipping,(Smaller items only) Or Arrange for a qualified garage equipment installation technician to attend your premises and install your Garage Equipment for you, ask a member of our sales team for details.
Our phone lines are open Monday - Friday 0800-1800 (UTC+1) to make a garage equipment enquiry outside of these hours, you can complete the Enquiry or Contact forms, or submit your selection of products as an enquiry and a member of our sales team will contact you at the earliest possible convenience.
Garage Equipment Online supply and deliver a wide range of garage equipment including;
Garage Equipment Online accepts payments by way of credit cards or Paypal, we also use third party credit providers who have highly competitive leasing & finance packages available to all clients for any of your garage equipment requirements (subject to status.)
When you buy your Garage Equipment from GEO you can rest assured you are dealing with a Company with an excellent reputation for supplying only the highest quality Garage Equipment.
For all Your Garage Equipment needs don't delay contact a member of our dedicated sales team today on +44 (0)151 601 4945.
The Garage Equipment Online Team
Garage Equipment Online Limited.55 Hamilton SquareBirkenheadMerseysideCH41 5AS
Phone: 0151 601 4945 - Twitter: @GEOWirral
Garage Equipment Online Limited is registered in the UK with the registration number: 10067195 and registered for VAT with the number: 238 7238 83
Any representation of price or costings on this site or should be deemed to be exclusive of Value Added Tax at 20% unless otherwise specified.
Garage Equipment Online Limited is authorised and regulated by the Financial Conduct Authority.
(Firm Reference Number: 757842)


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June 26, 2014
Red Painting Room Escape is point and click escape game created by Ainars for Escape Fan. Assume you had just moved into Japan where it was a tradition to decorate the livingroom with a red painting because in their faith it will keep the bad forces out of the building. One day you got home from the work and set yourself into comfort on the sofa watching a football match. Sudddenly your phone rang. It was your boss asking you to return to your workplace because an unexpected mistake came up with one of your projects. You get out to your car but found it locked however you had never locked it in your garden. You went inside and found the keyholder empty.


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DYFLOGEST655 Mulberry Road Manteno, Illinois United States of America
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This report was posted on Ripoff Report on 03/14/2011 09:58 AM and is a permanent record located here: http://www.ripoffreport.com/reports/dyflogest/manteno-illinois-60950/dyflogest-refuse-authorized-refund-request-for-returned-unsatisfactory-product-company-a-705739. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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The LaRue County High School Class of 2012 posed for a group photo May 3 at Abraham Lincoln Birthplace National Historic Park.
Free Movie Night kicks off the summer with a 2011 film "Hugo."
The movie will be shown at 7 p.m. Saturday, May 19 in the auditorium of the Hodgenville Civic Center (City Hall). There is no charge to attend.
The event coincides with the Goodtime Cruisers' classic car cruise-in on Lincoln Square.
Hugo is set in 1931 Paris. Asa Butterfield plays Hugo Cabret, a 12-year-old boy, who lives with his widowed father, a master clockmaker.
The Elizabethtown Community and Technical College Honors Reception to recognize outstanding academic achievement was April 27 at the State Theater in Elizabethtown.
Several local honors students were named. They include students who have attained and maintained a grade point average of 3.5 or above on a full year's worth of coursework at ECTC.
Katelyn Elizabeth Davila of Hodgenville and John Douglas Henderson of Summersville announce their engagement and forthcoming marriage.
The bride to be is a 2008 graduate of LaRue County High School and a student at Western Kentucky University where she is majoring in management with a double concentration in business administration and human resources management.
She is the daughter of Barbara Howard Davila of Hodgenville and Larry Davila of Phenix City, Ala., and the granddaughter of Lura Leigh Thomas of Hodgenville.
A Hodgenville woman is recovering from a two-vehicle crash that occurred April 26 in Washington County.
Judy D. Howell, 68, of Hodgenville, was driving a 2002 Ford Taurus SE west on KY 1754 in Willisburg when she collided with a 2004 Freightliner driven by Harry L. Hampton, 59, of Mayslick. Hampton was driving north on Hwy. 555, according to the Washington County Sheriff's Department.
According to the police report, Hampton told police that Howell did not stop at the intersection.
Sunday is Mother's Day in the United States and for most it will be a very special day. Telephone companies tell us it is their busiest day of the year. It is a day for remembering, for greetings and expressions of love.
Your mother may have been gone for many years, but there are still sounds and sights and smells of home, of screen doors banging in the summer time and the aroma of those fresh baked biscuits right out of the oven that greeted you as you got out of bed in the morning.
A New Hope woman bit and tried to stab a sheriff's deputy as she was placed under arrest in New Haven Sunday.
Rachel Lee McConnell, a.k.a. Rachel Lee Kemp, 29, had bench warrants from LaRue and Nelson counties issued against her when deputies arrived at 353 Center Street shortly before 8 p.m.
Deputies were called to the address on a report McConnell had locked herself inside and that there was possible drug activity, according to a report from the Nelson County Sheriff's Department.
May is Kentucky Water Awareness Month. We can observe it by helping keep our groundwater safe from contaminants.
Agricultural chemicals are an important part of farming, but, if misapplied, can lead to groundwater contamination. As farmers plant and grow crops this year, they should take steps to reduce the chance of farm chemicals in groundwater:
Read the manufacturer's label for each chemical and follow label directions for safe use and disposal.
This past weekend, my oldest grandson with his girlfriend, attended the Junior-Senior Prom. And I realized just how fast time goes by.
As I thought of my children's prom night, and even my own, I am amazed at the truth of scripture: "For what is your life? It is even a vapor (morning fog) that appears for a little time, and then vanishes away." James 4:14.
This time of year we all soon have the opportunity to enjoy locally grown strawberries. The Farmers Market is at the Extension Office parking area at 807 Old Elizabethtown Road 2-5:30 p.m. Tuesdays and Fridays.
Here's information on how to make your own strawberry jam or you can follow the manufacturer's instructions on any type of pectin product such as Sure Jell.
Uncooked Strawberry Freezer Jam
1 3/4 cups crushed strawberries (about 1 quart)
4 cups sugar
2 tablespoons lemon juice
Copyright © 2017
The LaRue County Herald is your source for local news, sports, events and information in LaRue County, KY, and the surrounding area.


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Bridging People + Machines
The core of Captricity's data platform, crowd-guided machine learning, combines the power of advanced machine learning and crowdsourcing to replace manual data entry with a single and reliable cloud-based solution. This unique pairing of people and machines delivers an unprecedented accuracy rate of 99.9%+, even for unconstrained handwriting.Download Overview: How Captricity Works
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This step is optional but will dramatically boost your chances of your profile being viewed by interested members. Tell people about yourself, your interests and upload any nice photos of yourself.
Utilise our website's sophisticated search to discover members who satisfy your needs. Or just flip through listings and discover singles that appear interesting.
Found someone who you like the look of? Send a note to them or just a wink and wait for their response. With a little luck you'll be on your way to a lifetime of happiness.
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No5 Chambers practice director Tony McDaid has commented following the proposed changes to legal aid and the resulting protest by nearly 100 barristers outside Birmingham Crown Court.
The government plans to cut £220m from the legal aid annual budget by 2018–19, which barristers believe will destroy the criminal justice legal system.
McDaid said: 'What they are doing is taking the profession back to Dickensian times. It means there will be lack of quality and there just won't be the representation people have come to expect… They run the risk of completely wrecking a system that has served the people well and something has to be done to stop this.'
Michael Duck QC of No5 Chambers said that the most serious worry was the long-term damage being done to the criminal justice system due to the lack of recruits to the Criminal Bar. He said: 'The simple question is: where is the next high-quality judiciary going to come from?'


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Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque Psoriasis
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study will test the clinical effectiveness and safety of apremilast compared with placebo as well as etanercept compared with placebo in the same group of patients with moderate to severe plaque psoriasis.
Apremilast (CC-10004) is a new oral agent that is under clinical development for the treatment of inflammatory autoimmune disorders, such as psoriatic arthritis, psoriasis, rheumatoid arthritis, and Behçet disease.
Etanercept is approved for the treatment of psoriasis; it is the most widely prescribed anti-tumor necrosis factor (TNF) for psoriasis.
Psoriatic Arthritis
Drug: Apremilast tablet 30 mg
Drug: Etanercept 50 mg
Drug: Placebo tablet
Drug: Placebo injection (saline)
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase 3B, Multicenter, Randomized, Placebo-Controlled, Double-Blind, Double-Dummy, Study Of The Efficacy And Safety Of Apremilast (CC-10004), Etanercept, And Placebo, In Subjects With Moderate To Severe Plaque Psoriasis
- Percentage of Participants Who Achieved a 75% Improvement (Response) in the Psoriasis Area Severity Index (PASI-75) for the Comparison Between Apremilast and Placebo at Week 16 From Baseline [ Time Frame: Baseline to Week 16 ]PASI-75 response is the percentage of participants who achieved at least a 75% reduction (improvement) from baseline in PASI score at Week 16. The improvement in PASI score was used as a measure of efficacy. The PASI was a measure of psoriatic disease severity taking into account qualitative lesion characteristics (erythema, thickness, and scaling) and degree of skin surface area involvement on defined anatomical regions. PASI scores range from 0 to 72, with higher scores reflecting greater disease severity. Erythema, thickness, and scaling are scored on a scale of 0 (none) to 4 (very severe) on 4 anatomic regions of the body: head, trunk, upper limbs, and lower limbs. Degree of involvement on each of the 4 anatomic regions is scored on a scale of 0 (no involvement) to 6 (90% to 100% involvement). The PASI score was set to missing if any severity score or degree of involvement was missing.
- Percentage of Participants Who Achieved a 75% Improvement (Response) in the Psoriasis Area and Severity Index (PASI) for the Comparison Between Etanercept 50mg SC QW and Placebo at Week 16 From Baseline [ Time Frame: Baseline and Week 16 ]PASI-75 response is the percentage of participants who achieved at least a 75% reduction (improvement) from baseline in PASI score at Week 16. The improvement in PASI score was used as a measure of efficacy. The PASI was a measure of psoriatic disease severity taking into account qualitative lesion characteristics (erythema, thickness, and scaling) and degree of skin surface area involvement on defined anatomical regions. PASI scores range from 0 to 72, with higher scores reflecting greater disease severity. Erythema, thickness, and scaling are scored on a scale of 0 (none) to 4 (very severe) on 4 anatomic regions of the body: head, trunk, upper limbs, and lower limbs. Degree of involvement on each of the 4 anatomic regions is scored on a scale of 0 (no involvement) to 6 (90% to 100% involvement). The PASI score was set to missing if any severity score or degree of involvement was missing.
- Percentage of Participants Who Achieved a Static Physician Global Assessment (sPGA) Score of Clear (0) or Almost Clear (1) With at Least 2 Points Reduction for Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: Baseline and Week 16 ]The sPGA is the assessment by the Investigator of the overall disease severity at the time of evaluation. The sPGA is a 5-point scale ranging from 0 (clear) to 4 (severe), incorporating an assessment of the severity of the three primary signs of the disease: erythema, scaling and plaque elevation. When making the assessment of overall severity, the Investigator should factor in areas that have already been cleared (ie, have scores of 0) and not just evaluate remaining lesions for severity, ie, the severity of each sign is averaged across all areas of involvement, including cleared lesions. In the event of different severities across disease signs, the sign that is the predominant feature of the disease should be used to help determine the sPGA score.
- Percent Change From Baseline in the Affected Body Surface Area (BSA%) for Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: Baseline to Week 16 ]BSA is a measurement of involved skin. The overall BSA affected by psoriasis was estimated based on the palm area of the participant's hand (entire palmar surface or "handprint" including the fingers), which equates to approximately 1% of total body surface area. BSA percent change from baseline (Visit 2 Week 0) was determined at each visit of the study, which is calculated as 100*(visit BSA - baseline BSA) / baseline BSA (%).
- Percentage of Participants Who Achieved a 50% Improvement (Response) in the Psoriasis Area Severity Index (PASI-50) for Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: From Baseline to Week 16 ]A participant was classified as having at least a 50% improvement in PASI score from baseline, which was equivalent to a percent change from baseline ranging from −100% to −50%. PASI score is based on an assessment of erythema (reddening), induration (plaque thickness), desquamation (scaling), and the percent area affected as observed on the day of examination.
- Change From Baseline in Dermatology Life Quality Index (DLQI) In Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: Baseline to Week 16 ]DLQI is a simple, compact, and practical questionnaire for use in a dermatology clinical setting to assess limitations related to the impact of skin disease. The instrument contains ten items dealing with the participant's skin. With the exception of Item Number 7, the participant responds on a four-point scale, ranging from "Very Much" (score 3) to "Not at All" or "Not relevant" (score 0). Item Number 7 is a multi-part item, the first part of which ascertains whether the participant's skin prevented them from working or studying (Yes or No, scores 3 or 0 respectively), and if "No," then the participant is asked how much of a problem the skin has been at work or study over the past week, with response alternatives being "A lot," "A little," or "Not at all" (scores 2, 1, or 0 respectively). The DLQI total score is derived by summing all item scores, which has a possible range of 0 to 30, with 30 corresponding to the worst quality of life, and 0 corresponding to the best.
- Change From Baseline in the Mental Component Summary (MCS) Score of the Medical Outcome Study Short Form 36-item (SF-36) Health Survey Version 2.0 in Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: Baseline and Week 16 ]
The SF-36 is a 36-item general health status instrument and consists of 8 scales: physical function (PF), role limitations-physical (RP), vitality (VT), general health perceptions (GH), bodily pain (BP), social function (SF), role limitations-emotional (RE), and mental health (MH). Scale scores range from 0 to 100, with higher scores indicating better health. Two overall summary scores were obtained − a Physical Component Summary score (PCS) and a Mental Component Summary score (MCS).
Scores from the 8 scales, PCS and MCS were transformed to the norm-based scores using weights from U.S. general population, with higher scores indicating better health. For norm based scores, change from baseline were calculated for the 8 scales and the two summary scales, where change = visit value − baseline value.
- Percentage of Participants With a Lattice System Physician's Global Assessment (LS-PGA) Score of Clear (0) or Almost Clear at Week 16 in Comparison Between Apremilast and Placebo and Etanercept and Placebo at Week 16 [ Time Frame: Baseline to Week 16 ]The Lattice System Physician's Global assessment by the investigator of psoriasis severity. Integrating ranges of BSA involvement with assessments of overall plaque severity (using a 4 point scale, from none to marked for the signs of plaque elevation, erythema and scale), the LS-PGA produces an overall assessment of psoriasis severity on an 8-point scale, ranging from clear to very severe. To determine the final score, the lattice portion is governed by the BSA and among the plaque qualities, weights plaque elevation as most important, erythema next, and scale least.
- Number of Participants With Treatment Emergent Adverse Events (TEAE) During the Placebo Controlled Phase [ Time Frame: From the start date on or after the first dose date of study drug and prior to Week 16 for those who entered the Apremilast Extension Phase (Weeks 16-104) or within 28 days of the last dose date for those who discontinued in the Placebo-Controlled Phase ]A TEAE is an AE with a start date on or after the date of the first dose of study drug and no later than 28 days after the last dose of study drug for those who discontinued early. An AE is any noxious, unintended, or untoward medical occurrence that may appear or worsen during the study. It may be a new intercurrent illness, a worsening concomitant illness, an injury, or any concomitant impairment of the subject's health, including laboratory test values, regardless of etiology. Any worsening (ie, any clinically significant adverse change in the frequency or intensity of a preexisting condition) should be considered an AE. A serious AE (SAE) is any untoward AE that is fatal, life-threatening, results in persistent or significant disability or incapacity, requires or prolongs existing in-patient hospitalization, is a congenital anomaly/birth defect, or is a condition that may jeopardize or may require intervention to prevent one of the outcomes listed above.
- Psoriasis Flare/Rebound [ Time Frame: From the start date on or after the first dose date of study drug and prior to Week 16 for those who entered the Apremilast Extension Phase (Weeks 16-104) or within 28 days of the last dose date for those who discontinued in the Placebo-Controlled Phase ]Psoriasis flare is an AE and represents an atypical or unusual worsening of disease during treatment. It is defined as a sudden intensification of psoriasis requiring medical intervention or a diagnosis of new generalized erythrodermic, inflammatory, or pustular psoriasis. Rebound is an AE and is defined as a severe and sudden worsening of disease that occurs after treatment has been discontinued. This exacerbation is characterized by a PASI ≥125% of baseline or a new generalized pustular, erythrodermic, or more inflammatory psoriasis after stopping therapy.
|Study Start Date:
|October 2012
|Study Completion Date:
|April 2016
|Primary Completion Date:
|July 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Apremilast 30 mg plus placebo injection
Apremilast 30 mg tablets orally twice a day (BID) plus once weekly (QW) evaluator/subject-blinded subcutaneous (SC) saline (placebo) injections
Drug: Apremilast tablet 30 mg
Apremilast 30 mg tablet orally BID
Other Names:Drug: Placebo injection (saline)
Once weekly evaluator/subject-blinded SC saline (placebo) injections (1 mL x 2 injections SC)
Other Name: Placebo
Experimental: Etanercept 50 mg plus placebo tablet
Etanercept 50 mg evaluator/subject-blinded SC QW injectins plus placebo tablets orally BID
Drug: Etanercept 50 mg
Etanercept 50 mg evaluator/subject-blinded SC QW injection
Other Name: EnbrelDrug: Placebo tablet
Placebo tablets BID
Other Name: Placebo
Placebo Comparator: Placebo plus SC saline placebo injections
Identically matching placebo tablets and evaluator/subject-blinded SC injections
Drug: Placebo tablet
Placebo tablets BID
Other Name: PlaceboDrug: Placebo injection (saline)
Once weekly evaluator/subject-blinded SC saline (placebo) injections (1 mL x 2 injections SC)
Other Name: Placebo
Detailed Description:
This is a phase 3b, multicenter, randomized, placebo-controlled, double-blind, double-dummy, study of the efficacy and safety of apremilast, etanercept, and placebo, in subjects with moderate to severe plaque psoriasis.
Approximately 240 subjects will be randomized 1:1:1 to the three treatment groups. All subjects will receive both tablets and injections through Week 16.
The study will consist of four phases:
- Screening Phase - up to 35 days
- Double-blind Placebo-controlled Phase - Weeks 0-16
- Apremilast Extension Phase - Weeks 16-104
- Post-treatment Observational Follow-up Phase
During the double-blind, placebo-controlled phase, subjects will receive treatment with one of the following:
- apremilast (APR) 30 mg tablets orally twice a day (BID) plus once weekly (QW) evaluator/subject-blinded subcutaneous (SC) saline (placebo) injections (1 mL x 2 injections SC), or
- etanercept (ETN) 50 mg evaluator/subject-blinded subcutaneous (SC) once weekly (QW) injections (2 x 25 mg) plus placebo tablets orally twice a day (BID), or
- placebo tablets and evaluator/subject-blinded subcutaneous (SC) saline (placebo) injections.
All subjects will be asked to participate in a 4-week Post-treatment Observational Follow-up Phase either upon completion of the study or upon discontinuation of investigational product for those subjects who terminate the study early.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males or females, ≥ 18 years of age
- Diagnosis of chronic, moderate to severe plaque psoriasis for at least 12 months prior to Screening, and a candidate for phototherapy and/or systemic (including etanercept) therapy
- Had an inadequate response, intolerance, or contraindication to at least 1 conventional systemic agent for the treatment of psoriasis.
- No prior exposure to biologics for treatment of psoriatic arthritis or psoriasis
Exclusion Criteria:
- Other than psoriasis, history of any clinically significant and uncontrolled systemic diseases; any condition, including the presence of laboratory abnormalities, which would place the subject at unacceptable risk if he/she were to participate in the study.
- Pregnant or breast feeding.
- Have failed more than 3 systemic agents for treatment of psoriasis.
- History of allergy to any component of the investigational product (IP), including human immunoglobulin (Ig) proteins or allergy to etanercept.
- Hepatitis B surface antigen or anti-hepatitis C antibody positive at Screening.
- Latent, active tuberculosis (TB) or inadequately treated TB; nontuberculous mycobacterial infection or opportunistic infection (eg, cytomegalovirus, Pneumocystis carinii, aspergillosis, Clostridium difficile).
- Have a history of, or ongoing, chronic or recurrent infectious disease
- Have received, or are expected to receive, any live virus or bacterial vaccination within 3 months before first administration of IP, or through Week 20 during the study.
- Had a Bacillus Calmette-Guérin (BCG) vaccination within 1 year prior to screening.
- History of positive human immunodeficiency virus (HIV), or have congenital or acquired immunodeficiency (eg, common variable immunodeficiency disease).
- Active substance abuse or a history of substance abuse within 6 months prior to Screening.
- Malignancy or history of malignancy, except for treated [ie, cured] basal cell or squamous cell in situ skin carcinomas and cervical intraepithelial neoplasia [CIN] or carcinoma in situ of the cervix with no evidence of recurrence within the previous 5 years.
- Psoriasis flare or rebound within 4 weeks prior to Screening.
- Topical therapy within 2 weeks of randomization or systemic therapy for psoriasis within 4 weeks prior to randomization
- Use of phototherapy within 4 weeks prior to randomization or prolonged sun exposure or use of tanning booths or other ultraviolet (UV) light sources.
- Any investigational drug within 4 weeks prior to randomization, or 5 pharmacokinetic/pharmacodynamic half lives, if known (whichever is longer).
- Prior treatment with apremilast or etanercept.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01690299
Hide Study Locations
|United States, Arizona
|Arizona Research Center
|Phoenix, Arizona, United States, 85023
|United States, California
|Bakersfield Dermatology and Skin Cancer Medical Group
|Bakersfield, California, United States, 93309
|University of California Irvine-Department of Dermatology
|Irvine, California, United States, 92697
|University of California San Diego Medical Center
|San Diego, California, United States, 92122
|United States, Colorado
|Horizons Clinical Research
|Denver, Colorado, United States, 80220
|United States, District of Columbia
|George Washington University
|Washington, District of Columbia, United States, 20037
|United States, Florida
|Florida Center for Dermatology, PA
|Jacksonville, Florida, United States, 32204
|Florida Academic Dermatology Center
|Miami, Florida, United States, 33136
|International Dermatology Research
|Miami, Florida, United States, 33144
|Renstar Medical Research
|Ocala, Florida, United States, 34471
|United States, Georgia
|Atlanta Dermatology, Vein and Research Center, PC
|Alpharetta, Georgia, United States, 30022
|United States, Illinois
|NorthShore University HealthSystem
|Skokie, Illinois, United States, 60077
|Southern Illinois University School of Medicine
|Springfield, Illinois, United States, 62702
|United States, Indiana
|Dawes Fretzin Clinical Research Group, LLC
|Indianapolis, Indiana, United States, 46256
|United States, Louisiana
|Dermatology and Advanced Aesthetics
|Lake Charles, Louisiana, United States, 70605
|United States, Maryland
|Lawrence Green, MD, LLC
|Rockville, Maryland, United States, 20850
|United States, New Hampshire
|Dartmouth Hitchcock Medical Center
|Lebanon, New Hampshire, United States, 03756
|United States, New Jersey
|Robert Wood Johnson Medical School
|Somerset, New Jersey, United States, 08873
|United States, New York
|Forest Hills Dermatology Group
|Forest Hills, New York, United States, 11375
|NYU Department of Dermatology
|New York, New York, United States, 10016
|United States, North Carolina
|University of North Carolina
|Chapel Hill, North Carolina, United States, 27516
|Duke University Medical Center
|Durham, North Carolina, United States, 27710
|Wake Forest University Health Sciences
|Winston-Salem, North Carolina, United States, 27104
|United States, Ohio
|University Hospitals Case Medical Center
|Cleveland, Ohio, United States, 44106
|Ohio State University Medical Center
|Columbus, Ohio, United States, 43230
|United States, Pennsylvania
|University of Pittsburgh Medical Center
|Pittsburg, Pennsylvania, United States, 15213
|United States, Tennessee
|Tennesse Clinical Research Center
|Nashville, Tennessee, United States, 37215
|United States, Texas
|Teckton Research
|Austin, Texas, United States, 78745
|United States, Virginia
|The Education and Research Foundation
|Lynchburg, Virginia, United States, 24501
|Virginia Clinical Research Inc
|Norfolk, Virginia, United States, 23507
|United States, Washington
|Dermatology Associates of Seattle
|Seattle, Washington, United States, 98101
|Australia, Queensland
|The Skin Centre
|Benowa, Queensland, Australia, 4217
|Australia, Victoria
|Sinclair Dermatology
|East Melbourne, Victoria, Australia, 3002
|Australia, Western Australia
|Fremantle Dermatology
|Fremantle, Western Australia, Australia, 6160
|Gairdner Hospital
|Victoria Park, Australia, 6100
|Rheumatology unit Ward 5C Queen Elizabeth Hospital
|Woodville, Australia, 5011
|Veracity Clinical Research
|Woolloongabba, Australia, 4102
|Cliniques Universitaires St-Luc
|Brussels, Belgium, 1200
|University Hospital Ghent
|Ghent, Belgium, 9000
|University Hospital of Liege CHU Liege
|Liege, Belgium, 4000
|Canada, Nova Scotia
|Eastern Canada Cutaneous Research Associates Ltd
|Halifax, Nova Scotia, Canada, B3H 1Z4
|Canada, Ontario
|Skin Center for Dermatology
|Peterborough, Ontario, Canada, K9J 5K2
|K. Papp Clinical Research Inc.
|Waterloo, Ontario, Canada, N2J 1C4
|Canada, Quebec
|Siena Medical Research
|Montreal, Quebec, Canada, H3Z 2S6
|Q & T Research Sherbrooke Inc.
|Sherbrooke, Quebec, Canada, J1H 4J6
|Czech Republic
|Dorothea, Kožní a korektivne dermatologické pracovište
|Chomutov, Czech Republic, 430 04
|Nachod, Czech Republic, 54701
|Východoceské dermatologické centrum Homea s.r.o.
|Pardubice, Czech Republic, 530 02
|Krajská nemocnice Pardubice, Kožní oddelení
|Pardubice, Czech Republic, 532 03
|Dermatovenerologicka ambulance
|Svitavy, Czech Republic, 568 02
|Koznia zilni ambulance
|Ústí nad Labem, Czech Republic, 400 10
|South Estonian Hospital Ltd
|Meegomäe Village, Võru county, Estonia, 65526
|Dermatology Clinic of Tartu University Hospital
|Tartu, Estonia, 50417
|Psoriasis Study Center
|Berlin, Germany, 10117
|Dermatologische Praxis
|Berlin, Germany, 10827
|Klinische Forschung Berlin - Buch GmbH
|Berlin, Germany, 13125
|University Hospital Carl Gustav Carus
|Dresden, Germany, 1307
|Hautklinik Universitatsklinikum Erlangen
|Erlangen, Germany, 91054
|University Hospital Frankfurt
|Frankfurt, Germany, 60590
|SCIderm GmbH
|Hamburg, Germany, 20354
|Institute for Health Services Research in Dermatology and Nursing - IVDP, University Medical Center
|Hamburg, Germany, D-20246
|Universitatsklinikum Heidelberg
|Heidelberg, Germany, 69115
|UniversitatsKlinikum Leipzig A.o.R.
|Leipzig, Germany, 4103
|Comprehensive Center of Inflammatory Medicine (CCIM) University Medical Center Schleswig-Holstein
|Lübeck, Germany, 23538
|Gemeinschaftspraxis Mahlow
|Mahlow, Germany, 15831
|University Hospital Munster
|Münster, Germany, 48143
|Praxis fr Dermatologie und Venerologie
|Wuppertal, Germany, 42275
|Tolna Megyei Balassa Janos Korhaz
|Szekszárd, Hungary, 7100
|Allergo-Derm Bakos Kft.
|Szolnok, Hungary, 5000
|LTD M & M centrs
|Adazi, Latvia, 2164
|Arija's Ancane's Family Doctor Private Practice
|Baldone, Latvia, 2125
|Riga 1st Hospital Skin and Sexually Transmitted Diseases Clinical Centre
|Riga, Latvia, 1001
|Adoria Ltd
|Riga, Latvia, 1011
|Family Doctor's Indra's Kenina's Practice
|Riga, Latvia, 1011
|Health Center of Talsi Ltd
|Talsi, Latvia, 3201
|Academic Medical Center
|Amsterdam, Netherlands, 1105 AZ
|Radboud University Medical Centre
|Nijmegen, Netherlands, 6500HB
|United Kingdom
|University Hospital of Wales
|Cardiff, United Kingdom, CF14 4XN
|Leeds Teaching Hospitals Trust
|Leeds, United Kingdom, LS7 4SA
|Whipps Cross University Hospital
|London, United Kingdom, E11 1NR
|St Helier Hospital
|London, United Kingdom, SM5 1AA
|George Eliot Hospital
|Nuneaton, United Kingdom, CV10 7DJ
|Study Director:
|Irina Khanskaya, MD
|Celgene Corporation
|Responsible Party:
|Celgene Corporation
|ClinicalTrials.gov Identifier:
|NCT01690299 History of Changes
|Other Study ID Numbers:
2012-000859-14 ( EudraCT Number )
|Study First Received:
|September 19, 2012
|Results First Received:
|July 2, 2015
|Last Updated:
|August 11, 2016
Keywords provided by Celgene Corporation:
psoriasis pill
psoriasis tablet
plaque psoriasis
plaque type psoriasis
moderate to severe plaque type psoriasis
psoriatic arthritis
Additional relevant MeSH terms:
Arthritis, Psoriatic
Joint Diseases
Musculoskeletal Diseases
Skin Diseases, Papulosquamous
Skin Diseases
Spinal Diseases
Bone Diseases
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Immunosuppressive Agents
Immunologic Factors
Leprostatic Agents
Anti-Bacterial Agents
Anti-Infective Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
ClinicalTrials.gov processed this record on May 25, 2017


text:
Neurosis: Honor Found In Decay
Record Release Photo Essay
On the evening of November 17, 2012, heavy music legends Neurosis played their hometown of Oakland in celebration of their tenth studio album called Honor Found In Decay. Neurosis also invited along Portland doom trio Yob, and the Canadian heavy metal band Voivod. Oakland's Fox Theater was packed to the brim with an audience that spanned multiple generations, proof that their legacy continues to thrive. As usual, Neurosis wasted no breath communicating with the audience, preferring to plunge straight into leaden, dismal riffs, primal howls and captivating visuals. In the spirit of Neurosis, my words end here and I leave you with my photos from that unforgettable night.


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Jason Morrison
Program Director
654 13th Street,
Preservation Park
Oakland, CA 94612
Phone: 1-510-251-1600
Fax: 1-510-251-2203
Jason Morrison is director of the Pacific Institute's Economic Globalization and the Environment Program, where he is currently studying private sector environmental initiatives, performance-based regulatory innovation, and voluntary international standards. Since 1997, Morrison has focused on the international environmental management standards - ISO 14000. He is a member of the US Technical Advisory Group to ISO Technical Committee 207 (the body that develops the ISO 14000 standards), as well as a U.S. delegate to TC 207 on standards pertaining to ecolabeling and environmental communications.
He currently serves as Chair of the ISO/TC 207 NGO Task Group. Morrison has also been investigating the emerging use of Environmental Management Systems (EMSs) in public policy. He is a board member of the Multi-State Working Group on EMSs (MSWG), a coalition of state and federal agencies investigating the role of EMSs in performance-based regulatory innovation. He sits on the EMS Advisory Council for NSF International Strategic Registrations, Ltd. and is an Advisory Committee member of the National Biosolids Partnership EMS Initiative.
Morrison holds a Master's Degree from Boston University's Center for Energy and Environmental Studies and a B.A. in Philosophy from the University of California, San Diego. In 1994, Morrison was a fellow with the Americans and World Affairs Fellowship Program in Berkeley, California. In addition to working on issues relating to international environmental standards and regulatory innovation, Morrison has conducted research on the sustainable management of freshwater resources and water planning in the southwestern U.S. His past research includes work on restoration of the Salton Sea in California and binational water management in the Colorado River border region.
Focus: Business, Environment, Globalization, United States, Americas
Selected Publications:
Morrison, J., K. Cushing, Z. Day, and J. Speir. 2000. Managing a Better Environment: Opportunities and Obstacles for ISO 14001 in Public Policy and Commerce. Pacific Institute report. Oakland, California.
Cohen, M., J. Morrison, and E. Glenn. 1999. Haven or Hazard: The Ecology and Future of the Salton Sea. Pacific Institute report. Oakland, California.
Morrison, J. and P. Gleick. 1998. "Water Resources Supply and Use in the Colorado River Basin," in Transboundary Freshwater Resources of North America. Commission for Environmental Cooperation. Montreal, Canada.
Postel, S., J. Morrison, and P. Gleick. 1998. Allocating Fresh Water to Aquatic Ecosystems: The Case of the Colorado River Delta. Water International. Volume 23 No. 3. September 1998.
Morrison, J. 1997. "An Analysis and Comparison of Two ISO 14001 EMS Pilot Project Evaluation Models," Prepared for U.S. Environmental Protection Agency. Pacific Institute working paper. Oakland, California.
Morrison, J. 1997. "Water Resource Depletion," in Life-Cycle Stressor-Effects Assessment (LCSEA): A Framework for Integrating Life-Cycle Impact Assessment with Environmental Assessment Techniques. A Practitioner's Manual. editors Rhodes, Kommonen, and Lindfors. Stockholm, Sweden.
Morrison, J., S. Postel, and P. Gleick. 1996. The Sustainable Use of Water in the Lower Colorado River Basin. Pacific Institute and Global Water Policy Project report. Oakland, California.
Morrison, J., P. Gleick, P. Loh, S. Gomez. 1996. "Sustainable Water Management in California: Three Trends Toward Success," in Managing Water Resources for Large Cities and Towns: Report of Beijing Water Conference. United Nations Centre for Human Settlements. Nairobi, Kenya.
Gleick, P., P. Loh, S. Gomez, J. Morrison. 1995. California Water 2020: A Sustainable Vision. Pacific Institute report. Oakland, California.
Language Fluency:English
Last Updated: Sep 22, 2006


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A Youth Ready for Adventure
As you stretch the sleep from your body you don't feel too many aches. Sitting up you straighten out your shirt and wonder why you've bound your breasts. You haven't padded your waist though so there's a slight dip to your hips. Looking around for a mirror you pout when you don't see one. It's probably best that way, given that your clothing looks dirty and crumpled.
Running your hands through your hair, you start again. Well if it's cut short you must have been disguising yourself as a boy. You smile. It's a good thing you haven't fully blossomed into womanhood then, if you remember your family's looks at all. Excitement creeps into your youthful veins. You're a girl disguised as a boy, locked in a tower.
There really isn't much to see in your cell, so you gingerly stand upon the cot. By raising yourself to your tippy toes, you can look through the barred window at your surroundings. A sigh escapes your lips. How did they ever know you wouldn't be able to stand a cell without a harbor view?
The sun is rising and the docks are starting to come to life. You're eyes flick over the three boats currently docked and at the men loading them. You suspect they are probably all muscled and perhaps have their shirts off by mid day. Oh, but that's not a very boyish thought. You berate yourself. Trying to be a boy is hard and you wonder how you managed to do it before.
Still you are alone in the tower and looking won't hurt, so your eyes move to the fourth boat. Here the cargo is being taken off the ship and then, barely visible on the horizon, a fifth boat catches your eye. Something about that boat which makes you squint to peer at it. The flag of origin, a white seal on a field of blue awakens memories inside you.
Turning you sit back down upon your bunk and review those memories. The first thing that comes to mind is that your name is Jordan. You were raised in Barrio, the land of ice and snow, far from this port. But why is the ship here? Has it come to take you home? Do you want to go home?
Your stomach growls, and a wave of homesickness washes over you. You'd never get this hungry if you were at home, where your every wish was granted. But to get home that means you need to board that ship, somehow. First, though, you need to get out of this cell and eat. Staring at the door opposite your cot you decide to...


text:
William: trappedMature
I let Rose lead me away from the parlour and the fuming Emily. She had totally caught me off-guard with her sudden embrace and passionate quick kiss. We were walking down a hallway now, toward the back part of the house, I took her hand and stopped her from moving on.
"What was that about?" I inquired, both curious and amused. A mocking smile on my face as I saw Rose blush when I turned her gently around.
"You can kiss me whenever you like, I think I can do the same," she responded.
My expression was that of bemusement and exhilaration by Rose answer. I placed my thumb and index finger on her chin, my lips brushed hers lightly. I felt shivers running down my spine, wanting to fully embrace her in a kiss, but I contained myself, tempting her.
"Jealous?" I whispered on her ear, kissing her earlobe.
Rose stood there, she gave me a captivating look, biting her lower lip. She then tiptoed to my ears, her face snuggled in my neck as she whispered, "maybe."
An indescribable feeling gripped my heart, a very welcomed feeling. She stepped back allowing me to see her face better, she gave me a teasing smile then left. As I saw her disappeared around the corner I made a mental note in my head: stay away from Emily.
I walked to where Rose had disappeared, before rounding the corner I felt a hand pressing my chest, suddenly my body was being pressed against the wall.
"Lord William," the female purred, her hands were moving about my chest in a ravaging manner. Her head rested on my chest, kissing my shirt. "Is that invitation still up?" She turned her head to my face, her eyes burning with desire.
"Maryann," I said curtly.
"I have missed you," she drew circles in my chest, moving her finger up to my neck. She drew closer, placing her lips on my neck, kissing it passionately. Her hands clutched the sides of my shirt as she tried to pushed her tiny figure to kiss my lips. I lifted my head out of her lips reach, her moaning was disgusting to me.
I placed my hands on her shoulder and got her away from my neck. She gave me a hurt look, her fingers touching her lips and playfully delineating her full lips, glossy under the light.
"Let's play," she whispered, "nobody will know. Remember the night we embraced in the garden under the stars? It was the happiest moment of my life and I know it was for you too."
"You are wrong," I snapped at her coldly. "Things change my dearest Maryann, I would suggest you would be less compliant to men."
Her eyes flashed with anger, "who are you to talk about that? You are always around flirting with anyone with legs and skirts." Her voice was a shrill.
"I don't offer my dignity," I replied. "Good day." I stepped away from her continuing my path. I turned to her with one last piece of advice, "Stay away from Jacque." I turned around, she had a quizzical look on her face. This advice was directed to her, I was thinking of Isabelle. My innocence was corrupted, I would not allow Isabelle and Rose to lose theirs.
I took a shortcut out to the front garden, avoiding contact with the parlour.
"Mister William," a voice I wished not to hear called at me, I stopped in my tracks and turn to watch Emily in the distance, her arms were crossed on her chest as she stride toward me. "I am glad I caught you before you go out." Her voice was full with mystery and secretive.
"I wouldn't like to spend such a beautiful day indoors," I said, "is there anything you need from me?"
"I will be concise," Emily said, "I saw you and that girl with the violet dress in the hallway, that was quite a show." She gave me a playful smile and place a hand on my chest, brushing off imaginary dust.
I cringed, "I assure you that was nothing..."
"What would my cousin Rose think of it?" she continued, cutting into my sentence, "Rose has always been my favourite cousin, she is so gentle and sweet..."
"I have no doubt about that," I said.
"I think highly of her and love her so much, I cannot hide what I saw from her," her voice was low, saying each word perfectly slow and powerfully, implying evilness. "Poor Rose will be devastated, don't you think?"
I gave her a haughty look, "I don't think Rose should know this. As you have so clearly stated, you love Rose and wouldn't want to see her sad. I can assure you, there is nothing between Maryann and me."
"William, William," she snapped, her hands were cupping my face. "Everyone knows your reputation in this manor, everyone knows you are a flirt. Who knows? Maybe you are playing with Rose too, she feels that way doesn't she?"
"You are wrong," I counter-reacted at her insolence, "Rose does not think that way. She knows my true feelings." Did I believed what I had said?
"You don't believe that yourself, do you?" she taunted. "How does it feels, Lord William? The charmer being charmed? Certainly no one believes you have true feelings for Rose, the question is, do you?"
I was aghast as I thought about this question, unable to utter an answer. Fear took possession of my limbs, my face was contorted with discomfort.
"Waltz with me tonight," she said, "at the ball my uncle is giving because of my brother and my arrival to the manor. Grant me one night full waltzes with you, and I won't say a word about it to Rose."
Everything was going well with Rose, I did not want to break her trust in me. My mind did not process clearly, everything was a blur. I wasn't sure what I answered, but when I left the manor I saw Emily smiled triumphantly


text:
The latest news from academia, regulators
research labs and other things of interest
|Posted: Dec 14, 2015
Spintronics, low-energy electricity take a step closer
|This is an illustration of topological surface states in bismuth iodide as seen by angle-resolved photoemission spectroscopy. (Image: Oleg Yazyev, EPFL)
|The technological promise of topological insulators has led to an intense search for optimal natural and man-made materials with such properties. Such research combines theoretical work that predicts what properties the structure of a particular material would have. The "candidate" materials that are identified with computer simulations are then passed for experimental examination to see if their topological insulating properties match the theoretical predictions.
|This is what the lab of Oleg Yazyev at EPFL's Institute of Theoretical Physics has accomplished, working with experimentalist colleagues from around the world. By theoretically testing potential candidates from the database of previously described materials, the team has identified a material, described as a "crystalline phase" of bismuth iodide, as the first of a new class of topological insulators.
|What makes this material particularly exciting is the fact that its atomic structure does not resemble any other topological insulator known to date, which makes its properties very different as well.
|One clear advantage of bismuth iodide is that its structure is more ordered than that of previously known topological insulators, and with fewer natural defects. In order to have an insulating interior, a material must have as few defects in its structure as possible.
|"What we want is to pass current across the surface but not the interior," explains Oleg Yazyev. "In theory, this sounds like an easy task, but in practice you'll always have defects. So you need to find a new material with as few of them as possible." The study shows that even these early samples of bismuth iodide appear to be very clean with very small concentration of structural imperfections.
|After characterizing bismuth iodide with theoretical tools, the scientists tested it experimentally with an array of methods. The main evidence came from a direct experimental technique called "angle-resolved photoemission spectroscopy". This method allows researchers to "see" electronic states on the surface of a solid material, and has become a key technique for proving the topological nature of electronic states at the surface.
|The measurements, carried out at the Lawrence Berkeley National Lab, proved to be fully consistent with the theoretical predictions made by Gabriel Autès, a postdoc at Yazyev's lab and lead author of the study. The actual electron structure calculations were performed at the Swiss National Supercomputing Centre, while data analysis included a number of scientists from EPFL and other institutions.
|"This study began as theory and went through the entire chain of experimental verification," says Yazyev. "For us is a very important collaborative effort." His lab is now exploring further the properties of bismuth iodide, as well materials with similar structures. Meanwhile, other labs are joining the effort to support the theory behind the new class of topological insulators and propagate the experimental efforts.
|Source: Ecole Polytechnique Fédérale de Lausanne


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