text:
HPPSC Recruitment Details: Job Advertisement for 30 Tehsildar & Officer postsApplications are invited through online mode up to 28.02.2015 in the following posts:-
Post Name: Tehsildar and Officer posts
No. of Posts: 30 Posts
Himachal Pradesh Jobs
Detail of vacancies:
The detail of vacancies is given below.
1. Four vacancies of Himachal Pradesh Administrative Service, Class-I (Gazetted) in the pay scale of Rs.15600-39100 + 5400 (Grade Pay). Out of these, one vacancy is reserved for the category of Scheduled Castes (S.C.), and one vacancy is reserved for the category of Ex-serviceman(UR). Remaining 02 vacancies are unreserved.
2. Five vacancies of Himachal Pradesh Police Service, Class-I (Gazetted) in the pay scale of Rs. 15600-39100+5400(Grade Pay) out of these, One vacancy reserved for the category of Ex-Serviceman(UR) and remaining 04 vacancies are unreserved.
3. Five vacancies of Tehsildar Class –I (Gazetted) in the pay scale of Rs.10300-34800+5000 (Grade Pay). Out of these, one vacancy is reserved for Scheduled Tribe (S.T.). Remaining 04 vacancies are unreserved.
4. Eight vacancies of Block Development Officers, Class –I (Gazetted) in the pay scale of Rs. 10300-34800 + 5000 (Grade Pay). Out of these, two vacancies reserved for the category of Scheduled Castes (S.C). Remaining 06 vacancies are unreserved.
5. Two vacancies of District Treasury Officer, Class-1(Gazetted) in the pay scale of Rs.15600-39100+5400 Grade Pay. Out of these one vacancy is reserved for the category of Scheduled Caste(S.C.) and one vacancy is unreserved.
6. Six vacancies of Excise and Taxation Officer, Class-I (Gazetted) in the pay scale of Rs. 10300-34800+5000/-Grade pay. Out of these one vacancy is reserved for the category of Gen.Ex-serviceman (UR), one vacancy is reserved for the category of OBC. Remaining 04 vacancies are unreserved.
The following post(s) will also be filled up on the basis of H.P.A.S. Combined Competitive Examination-2014:
1. Himachal Pradesh Administrative Services
2. Himachal Pradesh Police Services
3. Tehsildar
4. Excise & Taxation Officer
5. Block Development Officer
6. District Panchayat Officer
7. Manager, District Industries Centre;
8. District Welfare-cum-Probation Officers
9. Assistant, Registrar Co-operative Societies
10. District Employment Officer
11. District Treasury Officer
12. District Food & Civil Supplies Controller
13. Assistant Controller, Weights & Measures
Name of Organization
Himachal Pradesh Public Service Commission (HPPSC)
Name of Post
Tehsildar and officer posts
Latest News on
Last date
Official website
HPPSC Jobs 2015 - Eligibility Criteria:
1. A candidate must be a citizen of India.
2. Minimum Educational Qualifications
(a) A candidate must possess a Bachelor's Degree or its equivalent from a recognized University.
Candidates should download HPPSC Recruitment 2015 Notification for detailed information.
HPPSC Advt. 2015 - Selection Procedure: Himachal Pradesh Administrative Combined Competitive Examination will consist of three successive stages to complete the selection process.
Selection will be done on the basis of performance in Preliminary & Main examination and Viva-voce.
Age limit: A candidate must have attained the age of 21 years and must not have attained the age of 35 years on the first January- 2015, meaning thereby that candidates born on or after 02-01-1994 are underage whereas applicants born before 01-01-1980 are overage.
HPPSC Recruitment - Important dates:
Opening Date of Online Application: 29-Jan-2015
Last Date for Submission of Online Application: 28-Feb-2015
Examination Fee:
1. General Category: (including General Physically Disabled, i.e. orthopedically disabled, Deaf & Dumb, Hearing impaired, W.F.F., Ex-Servicemen relieved from Defence Services on their own request before completion of normal tenure of HP) - Rs. 400/-
2. Other State's candidates: (including reserved category(s) candidates of other states) - Rs. 400/-
3. S.C. OF H.P. /S.T. OF H.P. /O.B.C. OF H.P. (Ex-Servicemen of H.P. relieved from Defence Services on their own request before completion of normal tenure) - Rs. 100/-.
4. Ex-Servicemen of H.P. (Ex-Servicemen, who are relieved from Defence Services after completion of normal tenure) / Blind of H.P./ Visually Impaired of H.P. - No Fee.
The Candidates are required to pay a fee either by depositing the money in any branch of PNB by cash or by using Visa / Master Card Credit / Debit Card.
How to Apply at HPPSC Recruitment 2015Interested candidates who are eligible and want to apply for HPPSC recruitment can apply online. Candidates can submit their online application till 28/2/2015.
HPPSC Vacancies 2015 - Where for Apply: Candidates should apply only through online in website hp.gov.in/hppsc. Before applying, the candidates should
Procedure to Applying Online: Candidates are required to apply only through online mode by using the website http//hp.gov.in/hppsc. No other mode for submission of applications is allowed. Detailed instructions for filling up online applications are available on the above mentioned website.
Important Points before applying:
- The candidates must ensure their eligibility in respect of Category, Age and Essential Qualification(s) etc. as mentioned in the advertisement to avoid rejection at later stage.
- The candidates should exercise due care while entering their Mobile Numbers and E-Mail IDs in the Online Application Form for immediate intimation with regard to their application.
- The online Applications can be filled up to 28/02/2015 till 11.59 PM after which the link will be disabled.
Download Advertisement
Apply online.


text:
Tanana is so sweet Loves to play
Kenai is so sweet loves to play
Icicle, isnt she adorable!!
Male morkie puppy is for sale!!
Morkie puppy is for sale!!
So cute and little Morkie Puppy!
So Playful Morkie Little Boy Puppy!
Lucy loves listening to Jimmy Buffet on the beach
Jax love playing on the beach
Perfect lap dog, Morkie puppy
Benjamin..Adorable Male Morkie boy..Cute Cute Cute!!
Sweet morkie female looking for someone to love
Bentley...Adorable Morkie boy!!
Bentley..Adorable friend and wonderful companion!!
Princess. Beautiful Morkie girl !!
Scout is a cutie. He is a great fun friend perfect in every way !!
Petite little Morkie, Out to steal your heart!
Perfect little pocket pup, Morkie female
Such a cutie Morkie Female puppy!
Peg is such a sweetheart
Vixey is such a sweetheart
Anna is such a sweetheart UTD with vaccines Great with kids
Princess Ella ... Little morkie!
Adorable Cinnamon, Morkie puppy
Rafa is so sweet loves to give kisses
Pedro is so sweet loves to give kisses
Spunky & Full of Personality! Fluffy Baby Morkie!
This Baby Girl Morkie is Absolute Perfection!
Magical Morkie with Cinnamon Coat

subset: commoncrawl


text:
How to get started
- There are eight categories of freediving competition – three swimming-pool disciplines, two involving the use of weights, and three self-propelled. The weight-assisted dives are most dangerous and take divers to the greatest depths – the no limits record is 214 metres (702ft), set by the Austrian Herbert Nitsch in June
- There are numerous British freediving clubs, mainly in and around London. Try the Tribe Freediving Club, which meets at a private pool in Streatham, south London, and can offer training to beginners (http://www.deeperblue.net/ courses/tribe)
- For those who…


text:
Professional Web design for everybody
The task of setting up a Web page keeps getting easier. If you're a Linux user, you can choose from a variety of Linux-friendly HTML editing tools. But once you craft the headlines, format the text, and build in a few nice pictures, you may want to take your Web creations in a new direction. In this issue, we'll show you tools for taking your Web designs beyond the ordinary HTML. For readers who are ready for a big step into the world of professional design, our first cover story article shows how you can set up your own online store using the Open Source osCommerce application. Another article looks at how you can extend and simplify your Web pages using Cascading Style Sheets. Cascading Style Sheets give your sites a professional look and feel – and you don't have to be a programmer or Web guru to achieve this stylish appearance. The next article, "Painting your Site: Web page layouts with the GIMP," describes a technique for laying out graphics-rich Web pages with the GIMP image editor and converting the result to HTML. In our final cover story article "Flash in Linux," we discuss Linux tools for adding Flash animations to your Web pages.
Buy this article as PDF
(incl. VAT)
Buy Linux Magazine
Visit Our Shop
Direct Download
Read full article as PDF:Web_Design_Intro.pdf (103.27 kB)
Red Hat Announces OpenShift.io
Red Hat takes its IDE online.
Microsoft Bakes Linux into Windows Server
Microsoft is slowly becoming a Linux vendor.
Fearless Coyote, Linux Kernel 4.11 is Out
The new kernel makes swap implementation more scalable, which will help cloud providers.
Docker Appoints Steve Singh CEO
The new CEO comes from a very strong SaaS background.
Docker Announces Linux Kit and Moby Project
Both projects help organizations build their own containerized systems.
Ubuntu Returns to Gnome as Its Mobile Plans Shatter
Mark Shuttleworth has resumed the position of CEO of Canonical.
Microsoft is Shutting Down CodePlex
Microsoft's open source code hosting platform CodePlex will come to an end after a more than 10-year stint.
Fedora 26 Alpha Released
Comes with Gnome 3.24
Old Linux Kernel Bug Discovered
The bug was introduced back in 2009 and has been lurking around all this time.
OpenSSH 7.5 Released
The new release deprecates the sshd_config UsePrivilegeSeparation option.


text:
Simply download the small file, execute it on your PC and click the Open-button to load a new picture. Now move the cursor over the picture while pressing the left mouse-button - then stop pressing. The result is shown as preview. Repeat this step until the picture looks like you want it to. Save it as file. Or click the New-button for another try. Finally press the Print-button. Choose a printer, do the settings and click OK button - Finished!
Adobe PhotoShop 7.0 Trial
Drawing tools, filters, color adjustment capabilities, and other tools.
FunPics! - Caricature Maker 1.5.6
Make funny Caricatures from Photos.
Camouflage 1.03
The Camouflage PhotoShop plug-in allows you to generate army camouflage patterns and realistic animal textures.
Patterns generated can be used as seamless textures for 3D graphics or backgrounds.
Authentic army color presets included.
Snowflakes 1.02
With the Snowflakes PhotoShop plug-in you can create any type of snow you can imagine, ranging from mild and fluffy snowfall to heavy hailstorms and anything in between.
Amazing Photo Editor 7.7.3
Amazing Photo Editor is a powerful and easy-to-use software that help you view, edit, converter photos. 33 amazing image effects is included!
VaryView 1.4
Image viewer / converter for picture, photo, fax and CAD files created in popular raster and vector graphics formats. It allows you to view, convert, slide show and print your single or multi-page images in a variety of ways
Pixel 1.0 RC3 bld 445
Photoshop like image editor for Windows, Linux, MacOSX, BeOS, QNX, Solaris, MorphOS and DOS. Supports brushes, patterns, layers, styles, effects, plugins and much more...
MAGGI-Hairstyle and Make-up Software 6.0
MAGGI provides various cosmetic effects like changing the color of eyes, lips, face tan and shades and selection of mould and color hairstyles to suit the face.
Artistic Effects 1.8
Download this great collection of image filters that make up professional computer artist toolbox. This unique effects pack has all that you may need to start creating fantastic colorful artwork right away without having to pay mega bucks for it!
FunPhotor 5.2
ZeallSoft FunPhotor is fun and easy to use photo blending software.Put yourself, friends and family members on $100 bills! Swap faces and bodies! Change yourself into an astronaut or a personality on a poster. Change photos for practical jokes!
DWG to JPG Converter 2010.3 2010
DWG to JPG Converter is a batch converter that allows you to convert DWG and DXF files to TIF (TIFF), JPG (JPEG), BMP, GIF, PNG, TGA, PCX, WMF and EMF without the need of AutoCAD.
DWG to DXF Converter 2010.3 2010
DWG to DXF Converter is a batch DWG and DXF bi-directional converter that allows you to convert DWG to DXF, DXF to DWG without the need of AutoCAD.
Factory Image Converter 1.2
Factory Image Converter easily converts TIFF, JPEG, ICO, BMP, PNG, PSD images in batch. The interface is very user-friendly: you may preview any image in thumbnails or full sized. Apart from conversion, it can resize, crop or rotate images.
RasterVect 15.7.6
RasterVect can convert raster images (TIFF,BMP,JPEG...) to a vector format. Raster drawings can be imported by scanning paper drawings. Output vector formats (DXF,WMF,EMF,EPS and AI) are used by most CAD / vector programs (Corel Draw, AutoCAD).
Arabic Calligrapher 1.1
Arabic Calligrapher is a new concept graphic design development tool for Arabic Calligraphic Art work production
Arabic Calligrapher is a program to draw artistic calligraphy. By its vector technology, it is a complete calligrapher workshop.
Photo Effects Studio 2.55
A new program that will easily change your photos with the help of hundreds of unique filters. Professional photo effects are now available for everyone! Just select the necessary effect and enjoy the perfect result in a couple of seconds.
Cosmetic Guide 1.2.1
Not pleased with the wrinkles, expression lines and puffy eyes? Are you unhappy with a large birthmark? Now you can correct it right on photos! Your virtual cosmetic bag offers these tools: Skin Care, Emphasis, Smart Patch, Bleach Teeth and Liquify.
Artensoft Photo Editor 1.4
Simplify digital photo workflow and catalogue your images with Artensoft Photo Editor! The new image editor offers viewing, batch processing, picture adjustment and image editing features in a shell that is simple and easy.
Pos Free Photo Editor 1.35
Pos Free Photo Editor is a free photo editor from the authors of the best free professional photo editor - Photo Pos Pro free photo editor. The software is simple and very user friendly photo editor, that lets you easily view, and enhance your photos
Flash Console Wrapper 1.6.7
Convert Video to Flash in console. Use Adobe Flash Video Encoder in console mode. By defaut you can convert files using Adobe Flash Video Encoder. And if you need to automate conversion process from another application or *.bat file.


text:
Never before knowing her
touch, Hialeah Park is a lifelong love never fulfilled. My gaze first fell upon
the winter oasis lifetimes ago. Gardens and fountains of warmth, palm trees and
pink flamingos of the exotic, her siren song romanced
my impressionable young soul. Glamor by name, she has known millionaires,
movies stars, and heads of state. But more than that, she has lovingly invited
the majestic equine under her embrace. Horse racing is her game. Forego, Seattle
Slew, Alydar, and Spectacular Bid were childhood friends of mine. To her,
though, they were dinner guests, esteemed visitors that graced her banquets and
left those lucky enough to be in attendance with unbreakable memories. I may have watched from within four walls, but no matter, feeling her charms just the
same. Timeless beauty may be passé, but not her. She holds her elegance in a syncopated
rhythm, oblivious to counting years gone by. Where Seabiscuit began and War
Admiral finished, where Gen. Duke and Bold Ruler became entwined in history. Winds
have changed, times have blown in and out, and still Lady Hialeah holds on. Architectural
treasure and international flare, she is like no other. Patient, while singing
all the time, she is still calling me. I will let Citation stare into and through
my eyes, sharing a love, moment in time, and experience. Sopping up the day
like bread to gravy, I will be ten again. Passage
in hand, a destination or a lifetime date with destiny; Hialeah Park beckons me
home again, for the very first time.
Carrot Farm's UAE Derby runner-up Epicharis&n...
John Oxley's Classic Empire, who lost Saturday's $...
While Belmont Stakes 2017 will be the main focus o...
At long last we now know where the marvelous, two-...
On June 19, 2003 a seemingly typical field of nine...
Copyright © 2010 -
Immerse!, LLC


text:
A Knox man was arrested Friday after a search warrant was conducted at his residence.
Late Friday night, a search warrant was executed by Starke County officers in the 700 E. block of East State Road 8 in Knox. During the search, officers reportedly found methamphetamine, precursors to manufacture methamphetamine, controlled substances and drug paraphernalia.
Christopher Kennedy was arrested on preliminary charges of Possession of Methamphetamine, and Possession of Chemical Reagents or Precursors, Controlled Substances and Drug Paraphernalia, plus Maintaining a Common Nuisance. He has since bonded out of the Starke County Jail.


text:
Jaeger has hired a former Mulberry marketeer Graham Sim to help it shake off its "twinset and pearls" image and try to emulate the amazing transformation of rival brand Burberry.
Mr Sim has joined in the new position of marketing director. He left Mulberry in the middle of last year after launching a new collection in conjunction with up-and-coming designer Scott Henshall. He has been replaced by Philip Thomas
He was unavailable for comment but is thought to have joined in the past few weeks.
Jaeger, best known for its sensible tweeds and classic women's wear, is trying to shake off its dowdy image and grow as a fashionable brand.
The revolution is being masterminded by Pat Burnett, who took over of chief executive of the Jaeger and Viyella fashion retailer business last summer.
The company hired ad agency Bartle Bogle Hegarty last summer to advise of brand building.
It is expected to begin a new ad campaign in the spring, with a new collection designed by Bella Freud, dress designer to stars including Madonna and Courtney Love.
Over recent years rival clothing firm Burberry has undergone a remarkable transformation.
By drafting in new models including Kate Moss, it has shaken off a reputation for sensible raincoats and became a must-have street fashion brand.
In November its owner Great Universal Stores announced a stock market flotation for Burberry on the back of its success.


text:
Kushner reportedly encouraged to step aside as FBI investigates Russia contacts
Politico called Kushner the White House's " lead distraction" following what is being seen as a mostly successful first foreign trip for Trump.
Featured StoriesRead More >
United States
This brave Jewish soldier saved an American battalion during WWI
Abraham Krotoshinsky brought help to the members of the Lost Battalion, who were trapped by the Germans.
Israel & Middle East
Thousands rally in Tel Aviv for two states, against occupation
The rally took place under the banner of "Two States – One Hope."
From the JTA ArchivesRead More >
Trump's cuts to foreign aid budget are dangerous and inhumane
The president's proposal would undermine American leadership and harm the most vulnerable people in the world, writes the head of American Jewish World Service. By Robert Bank
From 70 Faces MediaRead More >
Life & Culture
How this African-American Jew uses cooking to fuse his two identities
In "The Cooking Gene," Michael Twitty explores the culinary heritage of African-Americans in the South and draws parallels to Jewish history.


text:
Music Articles
In Other News: Kanye Vs. W., Rappers Vs. Prison, New Michael Jackson Album
At times this week it seemed like Taylor Swift's million-selling album was the only music news happening. Yes, we know some other things happened. And while we're sure we haven't heard the last of Ms. Swift's accomplishment, let's avert our attention to some of the week's other headlines.
- We're sure you've already heard what former President George W. Bush thinks of Kanye West's outburst on national television five years ago ("It was a disgusting moment"), and you've probably heard about West's surprisingly sympathetic response ("We're all quick to pull a race card..."). Right? So we don't have to go into that?
- Anyone else who feels animosity toward Kanye but doesn't have a book contract will get a chance to hate on him at the end of the month, when he performs at the Macy's Thanksgiving parade in New York City (things full of hot air, clowns, and other uncreative jokes) alongside Jessica Simpson, Gladys Knight and Arlo Guthrie. It's like the lineup of the weirdest G.O.O.D. Friday track ever.
- News leaked out this week that Apple has decided to increase the length of free samples songs on iTunes from 30 seconds to 90 seconds. Billboard.biz looks at the logistical challenges that the shift will create for Apple as well as labels and music publishers. [Symphonic Distribution]
- Lil Wayne was released from Rikers Island in New York yesterday after serving eight months for weapons possession. He'll reportedly visit Arizona to deal with paperwork related to an earlier drug possession charge before heading home to Miami. [New York Daily News]
- Less than a year after his release from an Arkansas prison after serving seven months for his own weapons possession conviction, T.I. returned to prison after violating his parole. [Billboard]
- Gucci Mane, another Atlanta rapper who served time last year for violating his parole, was arrested on Tuesday for reckless driving, among other traffic violations. Charges were dropped on Wednesday "for want of prosecution." [Atlanta Journal-Constitution]
- Michael, a new album from Michael Jackson, will hit stores on December 14. Despite the Michael-through-the-ages collage on its cover, the album won't be a compilation of previously released material. Instead, it's a collection of material that Jackson recorded but never released. A single, called "Breaking News" will stream at michaeljackson.com starting Monday.
- Other bands making new album announcements this week: Australian dance-pop outfit Cut Copy (Zonoscope, due Feb 8), Northwest lit-rockers The Decemberists (The King Is Dead, jan 18), R.E.M. (Collapse Into Now, March)


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Holiday Trip
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You've done the most things you planned for holidays. But you still have 3 undone rows in your to do list! These 3 lines contain names: Gina, Selena and Kate. So don't wait. Finish your holidays with great sex with all of them!
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text:
Whenever I start up spiceworks, I have to type in my username even tho I check the "remember me" check box. Am I doing something wrong?
2 Replies
· · ·
Oct 31, 2008 at 9:45 UTC
I believe that the "remember me" box leaves a cookie for the site. Make sure that your browser is set to accept these cookies.
· · ·
Oct 31, 2008 at 12:38 UTC
My security is set to "medium" (see attachment) - I tried setting it to "accept all cookies" and it still wouldn't remember me.


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The Division of Pediatric Pulmonology, Allergy and Sleep Medicine offers full services for the evaluation, management and education of children and their families with asthma, other chronic respiratory diseases including chronic lung disease of prematurity and those requiring chronic mechanical ventilation, primary immunodeficiencies, food allergy, eosinophilic gastrointestinal disorders, atopic dermatitis, allergic rhinitis, latex allergy and sleep disorders. The Division has several research projects examining methods to improve asthma and other respiratory and allergic disorders in children.
University of Maryland Medical Center
Pediatric Sub-Specialty Clinic
22 S. Greene St., 5th floor
Baltimore, MD 21201
Appointments: 410-328-6749
Fax: 410-328-0679
Hanover, Anne Arundel County Practice
7556 Teague Rd., Suite 420
Hanover, MD 21076
Office: 443-755-0681
Appointments: 410-328-6749
Fax: 410-328-0679
University of Maryland Pediatrics at Lutherville
1302 Bellona Avenue
Lutherville, MD 21093
Appointments: 410-328-6749
Upper Chesapeake Physician Pavilion II
520 Upper Chesapeake Dr., Suite 509
Bel Air, MD 21014
Office: 410-879-7730
Appointments: 410-328-6749 or 410-879-7730
Fax: 410-328-0679
The Breathmobile® – A free mobile asthma clinic providing care for underserved/uninsured children at Baltimore City Schools/Head Start sites
Office/Appointments: 410-706-4000
Patient conditions
Research Activities
Comprehensive Evaluation
Specialized Treatment
Breathmobile® – A free mobile asthma clinic for underserved/uninsured children
Pediatric Sleep Program – Evaluation and management of suspected sleep disorders from infancy to adolescence
Physicians and Nurse Practitioners
Anayansi Lasso-Pirot, MD
Head, Pediatric Pulmonology, Allergy and Sleep
Assistant Professor of Pediatrics
Pulmonary Function Laboratory Medical Director
Special interests: Asthma in the Hispanic Population; Chronic Lung Disease; Aspiration Syndromes
Julia Tracey, CRNP
Nurse Practitioner
Mary Beth Bollinger, DO
Associate Professor of Pediatrics
Breathmobile® Medical Director
Special interests: Asthma; Food Allergy; Environmental Allergies; Immune Deficiencies
Anupama Kewalramani, MD
Assistant Professor of Pediatrics
Special interests: Asthma; Eosinophilic Esophagitis; Food Allergy
Lisa DiStefano, CPNP
Nurse Practitioner/Breathmobile®
Nursing Support
Gail Haddaway, RN
Jennifer Demetrakis, RN
Marilyn Mongilio, RN
Pulmonology/Sleep Medicine/Allergy
University of Maryland Medical Center
Division of Pediatric Pulmonology, Allergy and Sleep Medicine
737 W. Lombard St., Suite 314
Baltimore, MD 21201
Allergy/Pulmonology: 410-706-2443
Sleep: 410-706-3285
Breathmobile®: 410-706-4000
Fax: 410-706-0694
For appointments, please call 410-328-6749.


text:
Marble Arch Inn, London Overview
Check Room Rates and Reservation Availability in Marble Arch Inn, London
Marble Arch Inn, London Details
Marble Arch Inn Hotel Overview
A welcoming London hotel in a fantastic central
location close to Marble Arch, Oxford Street and Paddington Station.
Entire property is non-smoking, Safe at front desk, Snack bar, City maps, Microwave in the Lobby, Vending Machine
24-hour front desk, Wake-up calls, Ironing service, Fax service, Luggage storage, Tourist information
Paid parking is possible near the hotel.
Wi-Fi Internet free of charge in the rooms only
By train, from Heathrow Airport: Take the Heathrow Express to 'Paddington' train station. The hotel is a ten minute walk from here. Non-stop trains run every 15 minutes and the journey between Heathrow Central and London Paddington takes about 15 minutes (a few minutes more for Terminals 4 or 5).
By metro, from Heathrow Airport: If you'd rather save a few pounds you can take the Piccadilly Line to 'Earl's Court' and, once there, interchange to the District Line towards 'Edgware Road'. Get off at 'Notting Hill Gate' station. Take the red Central line towards 'Epping' station and get off at 'Marble Arch'.
The hotel is just 3 minutes walking from Marble Arch underground station. As you come out of the station turn right, take the next right, take the third left and go down the road to number 49-50.
This London hotel enjoys an enviable location
in Central London. A dizzying array of sights and attractions is within easy
walking distance and public transport options abound in the near vicinity. From
here it is a short walk to Madame Tussauds, Baker Street and Regent's Park to
the north, Selfridges, Oxford Street and Soho to the east, Hyde Park and
Speakers' Corner to the south, and Paddington Station, terminus of the Heathrow
Express, to the west. Marble Arch tube station is only a few minutes' walk from
the hotel and lies on the Central Line, connecting directly to the British
Museum, St. Paul's Cathedral and Liverpool Street Station.
Marble Arch Inn, London Hotel Details
Just around the corner from one of the
capital's most famous monuments, Marble Arch Inn London is well located for
easy access to Hyde Park and the legendary Speakers' Corner, Selfridges and
other exclusive shops on Oxford Street, and Paddington railway and tube station.
Nearby Marble Arch tube station is on the Central Line and can connect directly
to the British Museum and St Paul's Cathedral.
A friendly refurbished hotel, Hotel Marble
Arch has a 24hr reception providing tourist information, fax service and a
safety deposit box. A luggage storage service is also available.
Marble Arch Inn London has bright and clean
rooms some en-suite, some with shared bathroom facilities, all with a homely
decor and comfortable bedding. Wireless Internet is accessible in the rooms, in
addition to amenities such as a television with satellite access, direct dial
telephone, clock radio and tea and coffee making facilities.


text:
Welcome to the Nova Scotia Freemasons website.
Grand Master George R. O'Leary Acceptance Speech
To become a Freemason Ask a Freemason
The mission of the Masonic Foundation of Nova Scotia is to encourage the active practice of the Masonic Principles of Benevolence and Charity, and to promote a positive image of Freemasonry in the Community.
Grand Lodge of Nova Scotia 167 Coronation Avenue Halifax, NS, Canada B3N 2N2Telephone: (902) 423-6149 Fax: (902) 423-6254Email:firstname.lastname@example.com
Master: firstname.lastname@example.com 902-298-3340 cell
Secretary: firstname.lastname@example.com
From Highway 103 take Exit No.12 which leads to North St.. Masonic Hall is on the Left side of North St. Approximately 500 yards from Town Boundary
In area of Lodge Hall.
looking forward to a good year with several new brothers going through the degrees. More Masonic Education. And visitations to lodge in and outside the district.


text:
Guest reviews
Overall rating
7.8 Good
based on 68 reviews
Recent reviews
- All reviews
- Positive
- Neutral
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Find reviews that mention:
Crown Diamond Hotel offers an airport shuttle (available on request). You can unwind with a drink at the bar/lounge, and the restaurant is the perfect spot to grab a bite to eat. A terrace and a garden are offered, and rooms get the details right with pillow menus and slippers.


text:
You are currently using an unsupported web browser.
We support the latest versions of these browsers:
If you have any problems while attempting to download a browser, you should contact your organization's system administrator.
For any questions related to Cvent, feel free to contact our Customer Care team.
Welcome to Hotel La Perla. Located in the lovely town of Ascona, in the Italian side of Switzerland, just a 3- minute walk from downtown Ascona and its well-known lake promenade. We offer clean and spacious guest rooms with luxurious amenities to make your stay more comfortable. Our restaurant prov...
You must be logged in to view contact information for this supplier. Sign up for a free Cvent account today.
Image provided by Leonardo


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Native Eyewear Hardtop Xp Reflex Polarized Sunglasses, Asphalt
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Da Vinci Brunello Montalcino 2006
Winemaker Notes
Critical Acclaim
Dried flowers and dried mushrooms with hints of berries on the nose, follows through to a full body, with silky and polished tannins and a nutmeg, milk chocolate and berry aftertaste. Better after 2014.
Brunello Cantine Leonardo opens with loads of cinnamon and nutmeg with background tones of clove, earth, pressed violet and syrupy cassis. The wine closes with a long, spicy fade and a balanced touch of cleansing acidity.
The 2006 Brunello di Montalcino Cantine Leonardo is an inviting wine graced with open, radiant fruit and soft, engaging personality. Sweet spices and vanilla add complexity on the rich, creamy finish. This is an excellent choice for near-term drinking. Anticipated maturity: 2012-2020.


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- 1/2 cup extra-virgin olive oil
- 1 pound zucchini, halved lengthwise and thinly sliced
- 1 red bell pepper, cut into thin strips
- 1/2 small red onion, thinly sliced
- 4 thyme sprigs
- 4 garlic cloves—2 thinly sliced, 2 halved
- Salt and freshly ground pepper
- 1 tomato, coarsely chopped
- 1 small fennel bulb—halved, cored and sliced paper-thin
- 1/4 cup pitted kalamata olives, coarsely chopped
- 1 tablespoon drained capers
- Four 5-ounce tuna steaks, cut 1 inch thick
In a large, deep skillet, heat 1/4 cup of the olive oil. Add the zucchini, bell pepper, onion, thyme and sliced garlic and season with salt and pepper. Cook over high heat, stirring occasionally, until the vegetables are crisp-tender, about 7 minutes. Add the tomato, fennel, olives and capers, season with salt and pepper and cook, stirring, until the vegetables are tender, 2 to 3 minutes longer. Discard the thyme.
In a medium skillet, heat the remaining 1/4 cup of oil with the halved garlic cloves. Season the tuna with salt and pepper, add it to the skillet and cook over moderate heat for 3 minutes, turning once. Cover the skillet and cook the tuna over very low heat for 2 minutes longer; the tuna should still be slightly rare in the center.
Spoon the vegetables onto plates. Top with the tuna steaks and the browned garlic halves and serve.


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|Property type
|Minimum Stay
|3 nights
The Mushroom House is a stone-built cottage in a small row nestling on the eastern side of Rosedale about 1.5 miles outside Rosedale Abbey village. It is in a tranquil setting on a road which ends further up the dale and so has little traffic. The view from the front of the house looks out right across the valley of Rosedale with its farmhouses and extensive fields.
The row of old iron-miners' cottages is made up of a mixture of permanent residences and second homes and so the area is consequently very quiet and peaceful. You can step outside the door, pull on your walking boots or get on your bike, and set straight off into Rosedale and the surrounding moors and dales for a gentle stroll or a serious jaunt – whatever suits you – there are no pressures out here away from it all.
If you want to explore a little further then in a one-hour radius you have everything from the wonderful seaside town of Whitby, the quaint Runswick Bay, the magnificent Castle Howard, ancient York, pretty Helmsley and even a theme park at Flamingoland not to mention Scampston Gardens and Dalby Forest. This is just a small selection and there's more information in the Location section of this site and in the box full of leaflets and guides in the cottage itself.
Rosedale Abbey village has two tea-shops and three hostelries (all serving food) and there are other excellent places a few miles further away such as the New Inn at Cropton (with its own brewery) and the Blacksmiths at Lastingham. Then of course there's always Whitby fish and chips!
The house itself has 3 bedrooms upstairs (1 with super-king-sized bed, 1 with double bed and 1 with single top bunk and a child's pull-out bed) and a lounge, kitchen and bathroom downstairs. We have decorated and furnished the house to a high standard so that our guests will feel well looked-after, relaxed and at home. The comfortable lounge has two sofas and an open fire. All three bedrooms are decorated in individual styles with lovely views from all windows. There's a garden to play in at the front and a secluded lawn at the back ideal for barbeques on the fire pit.
The house has a modern and well-equipped kitchen as well as a modern bathroom with bath, shower, basin & WC (towels not provided). At the front of the house is a stone patio which looks out over beautiful Rosedale. At the rear is a secluded lawn backing onto the fields and ideal for sitting quietly or barbecuing.
If you want a real idea of the place then read the reviews our past guests have kindly written. We couldn't have put it better ourselves.
We are Michael & Jackie Reeder (accountant & teacher respectively) and live in Sheffield. We have a 30-year old son (budding entrepreneur) and a 26-year old daughter (junior doctor). We both grew up in Stockport but have lived in Sheffield for over 30 years now. We bought the house in 2003 and for the 10 years up until 2013 we worked to bring the house up to its current standard whilst at the same time enjoying many happy times there and on the North Yorkshire coast with friends and family. The house is furnished and decorated as a second home for us and we hope it feels like home and not just somewhere to sleep whilst on holiday in North Yorkshire.
Jackie Reeder purchased this cottage in 2003
This house has been both our escape from our busy city lives and the base for some wonderful times with friends and family. Its location in the lovely surroundings of Rosedale with just a 20 minute walk down into Rosedale Abbey village was ideal and it felt far enough away from the rat race to relax the instant we got there.
The peace and quiet (you can truly often only hear a cockerel crowing or an owl hooting when you sit out on the front patio or in the back garden).
The view out across Rosedale is lovely at any time of year.
Rosedale Abbey village with its couple of small tea-shops and two nice drinking/eateries is just the right size with friendly local people but never too busy.
The village is in an ideal location for countryside pursuits, visits to the seaside and days out at the many attractions in the surrounding area.
We spent a few days in The Mushroom House and had the most wonderful holiday in the totally quiet, peaceful and beautiful surroundings of Rosedale Abbey. The house is very comfortable, very well equipped and very tastefully furnished. Everything you might need is there and, even more importantly; everything works !!! Whoever decorated and equipped this house must have thought very carefully about what any holiday makers could wish for during their stay.
The location is wonderful, remote but also so close to the next village, to shops or restaurants and pubs. The views from the living room of the house are superb and we loved sitting and eating our evening meals outside in the front garden. We were lucky as the weather was very good and we also had some very enjoyable walks in the nearby countryside.
Dans cette très jolie maison j'ai adoré les "petits détails" qui font toute la différence ...le petit lavabo dans la chambre principale, la table qui se plie dans la salle de séjour et les chaises qui disparaissent dans le placard afin de donner plus de place, les draps et couvertures de duvet en vrai cotton etc...
Ayant passé une si bonne semaine dans la maison nous avons décidé de réserver à nouveau pour l'année prochaine et nous recommanderons cet endroit si joli et pittoresque à nos amis en Angleterre mais aussi en France.
Comfortable cottage, very well equipped in a superb location. Very clean
Beautiful & peaceful surroundings. Very clean & modern deco in the cottage. The stairs are quite steep so might not be ideal for elderlies & babies but our patents in early 70th & 5 yrs son were ok.
Had a wonderful short break in this cottage. Very well equipped and in a beautiful setting with great walks direct from the cottage door. Would highly recommend.
A well equipped, warm and very comfortable house in beautiful location. Excellent walking straight from the front door and splendid food/drink at the Coach House Inn. Hope to return.
Clean, cosy, clever space saving features. Quiet and so beautiful. Such a smooth booking and arrival/departure experience.
I enjoyed my stay very warm and cosy. Lovely walks very nice place to visit. I never stayed for the full 5 days as it started snowing really badly. If I visit again I'd come earlier in the year. Apart from the snowfall excellent place to visit and lovely cottage. Thank you.
The village
Rosedale Abbey is a small village in the North Yorkshire Moors surrounded by beautiful countryside ideal for those who love walking or cycling. The house is 1.5 miles outside the village in a tranquil setting with great views. The village, which has two cafes and three welcoming pub/restaurants all serving food, is popular for visitors but never too busy. There is also a fun 9-hole pitch & putt golf course on a hillside as well as Gillies Jones designer glassworks.
Whether you want a relaxing time away from it all, a trip to to the coast, a walk or cycle in the North York Moors or trips to stately homes and gardens all topped off with afternoon tea or a refreshing drink and a tasty meal then all are within easy reach of The Mushroom House.
The coast
It is a 30 minute scenic drive over the moors to the famous seaside town of Whitby where you will find numerous cafes, restaurants, interesting shops, and all the usual seaside attractions. Enjoy a walk around the bustling harbour, an ice-cream on the beach and an excellent fish and chip supper in a restaurant overlooking the sea. Sandsend Beach and Runswick Bay are only 35 minutes drive from the Mushroom House and are wonderful for walking and swimming. Fresh Whitby crab and fish are often on the menu in local cafes and restaurants. Scarborough is about an hour away. Robin Hood's bay and Staithes are charming little seaside places that are well worth a visit.
Local area and attractions
The market town of Helmsley is only 13 miles away and has many attractions including Duncombe Park, Rievaulx Abbey, The Walled Garden with its excellent cafe and lovely little shops selling local goods. The ancient city of York is within reach and makes a great day out (about a 1 hour drive away). The famous stately home of Castle Howard is about 40 minutes away. The steam trains of the North York Moors Railway run from nearby Pickering through the countryside to Whitby via several village stops including Goathland where the TV series Heartbeat was filmed and whose station might be better known as Hogwarts Station. Flamingoland is an adventure theme park about 14 miles away on the road to Malton and a little further along the same road is Eden Camp, a fascinating museum about life in WW2. Rydale folk museum and Dalby forest are also excellent days out for families. In the spring you should visit Farndale and walk along the river to admire its beautiful display of thousands of wild daffodils.
|Rate Period
|Weekend Night
Summer Half Term 2017
May 27 2017 - Jun 2 2017
3 night minimum stay
Summer 2017
Jun 3 2017 - Jul 14 2017
3 night minimum stay
Summer Holiday 2017
Jul 15 2017 - Sep 1 2017
3 night minimum stay
Early Autumn 2017
Sep 2 2017 - Sep 29 2017
3 night minimum stay
Autumn 2017
Sep 30 2017 - Oct 20 2017
3 night minimum stay
Autumn Half Term 2017
Oct 21 2017 - Oct 27 2017
3 night minimum stay
Winter 2017
Oct 28 2017 - Dec 15 2017
3 night minimum stay
Christmas 2017
Dec 16 2017 - Jan 5 2018
3 night minimum stay
|No additional mandatory fees
Please contact us to enquire about alternative start dates and short break prices.


text:
Large neutral amino acids in the treatment of PKU: from theory to practice
- First Online:
- Received:
- Revised:
- Accepted:
DOI: 10.1007/s10545-010-9216-1
- Cite this article as:
- van Spronsen, F.J., de Groot, M.J., Hoeksma, M. et al. J Inherit Metab Dis (2010) 33: 671. doi:10.1007/s10545-010-9216-1
- Citations
- 1.3k Downloads
Notwithstanding the success of the traditional dietary phenylalanine restriction treatment in phenylketonuria (PKU), the use of large neutral amino acid (LNAA) supplementation rather than phenylalanine restriction has been suggested. This treatment modality deserves attention as it might improve cognitive outcome and quality of life in patients with PKU. Following various theories about the pathogenesis of cognitive dysfunction in PKU, LNAA supplementation may have multiple treatment targets: a specific reduction in brain phenylalanine concentrations, a reduction in blood (and consequently brain) phenylalanine concentrations, an increase in brain neurotransmitter concentrations, and an increase in brain essential amino acid concentrations. These treatment targets imply different treatment regimes. This review summarizes the treatment targets and the treatment regimens of LNAA supplementation and discusses the differences in LNAA intake between the classical dietary phenylalanine-restricted diet and several LNAA treatment forms.
Cerebrospinal fluid
Large neutral amino acids
Phenylalanine hydroxylase
- Phe
In phenylketonuria (PKU, OMIM 261600), dietary restriction of phenylalanine (Phe) has been the cornerstone of treatment for over 50 years. The result of dietary treatment is a near normal cognitive outcome, although mild neuropsychological disturbances may still occur (Christ et al. 2010). Large neutral amino acids (LNAAs) have been suggested as an alternative treatment to further improve outcome. Possible LNAA treatment targets include reduction of brain Phe concentrations (Berry et al. 1982; Jordan et al. 1985; Pietz et al. 1999), reduction of blood Phe concentrations (Matalon et al. 2006), augmentation of cerebral neurotransmitter synthesis (Lou et al. 1985; Güttler and Lou 1986; Lou et al. 1987; Lykkelund et al. 1988), and/or elevation of brain non-Phe LNAA concentrations (Van Spronsen et al. 2009). In this article, we summarize the reports of the clinical trials of LNAAs and the rationales behind the use of LNAAs.
Apart from Phe, LNAAs include tyrosine, tryptophan, threonine, methionine, valine, isoleucine, leucine, and histidine (Van Spronsen et al. 2009). In healthy individuals, all of these except tyrosine are essential amino acids. In patients with PKU, tyrosine has become an essential amino acid. LNAA treatment as an alternative to dietary Phe restriction was suggested as early as 1948 (Christensen et al. 1948) and first studied in rats in 1976 (Andersen and Avins 1976). Since then, different combinations of LNAAs have been designed, based on different rationales and treatment targets. Some LNAA combinations contain arginine and/or lysine, neither of which is an LNAA.
This paper reviews different treatment regimes and different treatment rationales in LNAA supplementation.
Rationale A: LNAA supplementation to decrease cerebral Phe concentrations
The underlying rationale for this therapeutic strategy is that elevated brain Phe concentrations are considered to be neurotoxic. Because all LNAAs share a common transport system in order to enter the brain, and high plasma concentrations of LNAAs may block the transport of Phe into the brain (Pardridge 1998), increasing blood LNAA concentrations may reduce uptake of Phe into the brain. This hypothesis was first studied in rats with experimental hyperphenylalaninemia. LNAA-treated hyperphenylalaninemic rats were shown to have significantly reduced brain Phe concentrations compared to untreated hyperphenylalaninemic control rats, at similar blood Phe concentrations (Andersen and Avins 1976). Later studies in PKU patients showed that supplementation with valine, isoleucine, and leucine resulted in slightly improved neuropsychological function in patients with PKU (Jordan et al. 1985; Berry et al. 1990). More recent studies included the administration of all LNAAs. Pietz et al. (1999) and Moats et al. (2003) showed that oral LNAA supplementation reduced brain Phe concentrations, and improved neurophysiological and neuropsychological functioning (Pietz et al. 1999; Moats et al. 2003; Schindeler et al. 2007). Differences in outcome may be related to composition, dosing, route of administration, and duration of the supplementation period.
Rationale B: tyrosine and/or tryptophan supplementation to increase cerebral neurotransmitter synthesis
The rationale for this therapeutic strategy is that high plasma Phe concentrations result in decreased brain neurotransmitter concentrations. This is reflected by reduced brain neurotransmitter concentrations in the PKU mouse brain (Puglisi-Allegra et al. 2000; Pascucci et al. 2002, 2008, 2009), and by reduced concentrations of dopamine and serotonin and their metabolites in PKU patients, both in cerebrospinal fluid (CSF) (Butler et al. 1981; Lou et al. 1985; Burlina et al. 2000), and in autopsied brain tissue (McKean 1972). In PKU patients with an unrestricted natural protein intake, tyrosine and tryptophan supplementation have been shown to improve neurotransmitter metabolism, reaction time, and vigilance (Güttler and Lou 1986; Lou et al. 1987; Lykkelund et al. 1988), suggesting that dietary treatment could be replaced by a combination of tyrosine and tryptophan. Further support for such a treatment strategy was based on the theory of prefrontal lobe dysfunction (Diamond et al. 1994). This theory presumes that the prefrontal cortex is most affected by dopamine depletion, because dopaminergic neurons innervating the prefrontal cortex have relatively high levels of activity and higher dopamine turnover, inducing dopamine-dependency. Following these lines of consideration, large doses of tyrosine or L-dopa were expected to have a positive effect. However, later studies with large doses of tyrosine or L-dopa did not show positive results (Lou 1994; Mazzocco et al. 1992; Pietz et al. 1995; Smith et al. 1998; Ullrich et al. 1996).
Rationale C: LNAA supplementation to decrease blood Phe concentrations
This therapeutic strategy of supplementing LNAA is based on the rationale that LNAA transport not only occurs at the blood–brain barrier (BBB), but also at the gut–blood barrier. After performing studies in mice, Matalon et al. (2003) performed an open and a double-blinded trial in patients, who received LNAAs three times daily with meals, while patients' regular diet was unchanged (Matalon et al. 2006, 2007). A decrease in blood Phe concentrations up to 50% of initial values was found on LNAA supplementation of 0.5–1.0 g kg−1 day−1 (Matalon et al. 2006, 2007). This suggests that LNAA supplementation superimposed on regular dietary treatment may reduce Phe absorption in the gastrointestinal tract. If reduction in blood Phe concentrations indeed results from reduced Phe absorption, supplementation of all LNAAs at this dosage may not be required, as supplementation with threonine up to 50 mg/kg is reported to be sufficient to reduce blood Phe concentration by 20–50% (Sanjurjo et al. 2003). In addition, the reduction of blood Phe concentrations following LNAA supplementation may at least partly result from increased protein synthesis resulting from increased essential amino acid availability, in case of essential amino acid deficiency. However, it is largely unknown whether the patients studied had essential amino acid deficiencies (due to insufficient intake of natural protein and/or protein substitute), as so far, none of the clinical studies on the effects of LNAA supplementation quantified the amount of natural protein and protein substitute intake patients used. Finally, reduced blood Phe concentrations on LNAA supplementation may just be a matter of timing of blood sampling, as suggested by Prof. Bachmann (personal communication).
Rationale D: LNAA supplementation to increase cerebral amino acid concentrations
Reduced brain LNAA concentrations have been reported in PKU mice (Smith and Kang 2000; Pascucci et al. 2002, 2008). In autopsied brain tissue of PKU patients, McKean reported reduced tyrosine concentrations (McKean 1972). Restoring reduced brain LNAA concentrations in PKU may improve cognitive outcome. The rationale for LNAA supplementation to increase cerebral LNAA concentrations is, again, that LNAAs share the same transport system as Phe for entering the brain. Where rationale A hypothesizes that it is important to decrease the brain Phe concentration, rationale D hypothesizes that a deficiency in any essential amino acid in the brain may affect brain (protein) metabolism. Consequently, rationale D focuses on the effect of LNAA treatment on brain LNAA concentrations, rather than on (a decrease in) brain Phe concentrations. Hoeksma et al. (2009) showed that a significant negative relationship exists between plasma Phe concentration and cerebral protein synthesis in patients with PKU. However, this finding does not differentiate between the influence of elevated brain Phe concentrations and reduced brain non-Phe LNAA concentrations on cerebral protein synthesis.
Rationale E: comparison of LNAA intake in LNAA treatment and present dietary treatment
Recent trials with LNAA supplements in PKU patients include LNAA alone (Pietz et al. 1999), LNAA with extra lysine and/or arginine (Koch et al. 2003; Moats et al. 2003; Matalon et al. 2006, 2007; Schindeler et al. 2007), or only threonine (Sanjurjo et al. 2003). Whatever combination of amino acids is given, LNAA treatment strategies start with a more or less normal (i.e., unrestricted) intake of natural protein. The response of blood Phe concentrations to LNAA treatment (Pietz et al. 1999; Koch et al. 2003; Moats et al. 2003; Matalon et al. 2006, 2007; Schindeler et al. 2007) is comparable to the response of blood Phe concentrations to the protein substitutes in the traditional dietary treatment (MacDonald et al. 1996; Crone et al. 2005).
Several assumptions underlie the calculated values. First, the dose of amino acid mixture in conventional treatment is set at 1.0 g kg−1 day−1 rather than the RDA (0.8 g kg−1 day−1), correcting for the assumed 20% of the mixture that is not absorbed in the gastrointestinal tract. Second, in conventional treatment, LNAA intake resulting from natural protein intake is not taken into account, as the natural protein in this treatment is assumed to be of relatively low nutritional value. However, the distinction between protein of relatively low and high nutritional value has not been applied to the prescribed LNAA intake at RDA of healthy controls, resulting in some inconsistencies.
Based on these calculated prescribed LNAA intakes, Fig. 1 demonstrates that LNAA intake in PKU is higher than in healthy controls, regardless of the specific treatment given. Moreover, LNAA intake on LNAA supplementation is higher than LNAA intake on conventional treatment. However, the difference in LNAA intake between these two treatment forms is small relative to the difference between conventional treatment and the dietary regimen studied by Matalon et al. Finally, LNAA intake on the treatment strategy studied by Matalon et al. clearly results in a higher LNAA intake than either conventional therapy or LNAA supplementation, and markedly exceeds LNAA intake of a healthy control.
When LNAA treatment is discussed, not only the dose but also the composition is important. It is remarkable that LNAA treatment would need the addition of the non-LNAA lysine and arginine. When the primary aim is to block the entrance of Phe into brain, this would favor LNAA supplements consisting of specific amino acids, such as leucine, isoleucine, and methionine, that are considered to be highly effective at decreasing the cerebral Phe concentration (Hargreaves and Pardridge 1998). Following that hypothesis, giving 0.5 g kg−1 day−1 of all LNAA together with lysine and arginine might be changed into 0.5 g kg−1 day−1 of leucine, isoleucine, and/or methionine (Hargreaves and Pardridge 1998).
When the primary aim is to increase the influx of tyrosine and tryptophan, this would favor the supplementation of only tyrosine and tryptophan to increase the synthesis of the neurotransmitters dopamine and serotonin in the brain. Following that hypothesis, giving 0.5 g kg−1 day−1 of all LNAA (with or without lysine and/or arginine) might be changed into 0.5 g kg−1 day−1 of tyrosine and tryptophan. This is clearly above the doses ever given to PKU patients so far (Lou et al. 1985, 1987; Güttler and Lou 1986; Lykkelund et al. 1988). When, however, increasing the cerebral concentrations of all essential amino acids is the primary aim, all essential amino acids should be given in such a way that normal concentrations of all essential amino acids are achieved, taking the Km of each amino acid into account.
Summary of current treatment strategies in LNAA supplementation
LNAA supplementation may have several treatment aims: reducing brain Phe concentrations, reducing plasma Phe concentrations, increasing cerebral neurotransmitter concentrations, and increasing cerebral essential amino acid concentrations. Although LNAA treatment in PKU was initially intended to be unrestricted natural protein intake combined with LNAA supplementation, it should be noted that not all authors studied LNAA supplementation in this manner. This deserves attention when interpreting the findings below.
First, LNAA supplementation has been found to reduce brain Phe concentrations in patients, even at mean plasma Phe concentrations >1,000 μmol/L (Pietz et al. 1999; Koch et al. 2003). Second, LNAA supplementation may reduce plasma Phe concentrations (Matalon et al. 2006, 2007; Sanjurjo et al. 2003), although not all authors report this effect (Pietz et al. 1999; Koch et al. 2003; Moats et al. 2003). Third, data suggest that supplementation with only tyrosine and tryptophan does not sufficiently correct biochemical and neuropsychological abnormalities. However, recent LNAA trials supplement LNAA at 0.5 g kg−1 day−1, a dose much higher than that studied for tyrosine and tryptophan supplementation. At this dose, the effect of LNAA supplementation on cerebral neurotransmitter concentrations is currently unknown. Fourth, LNAA supplementation combined with unrestricted natural protein intake has been suggested to increase cerebral essential amino acid concentrations. This hypothesis remains to be studied in future trials.
In conclusion, LNAA treatment is seen as an alternative to conventional dietary PKU treatment. Although usually considered to refer to a single specific treatment modality, this paper shows that LNAA treatment may refer to at least two different LNAA treatment strategies, i.e., natural protein intake at RDA with LNAA supplementation, and conventional dietary therapy combined with LNAA supplementation. In addition, LNAA treatment may refer to supplementation of single amino acids, such as tyrosine, tryptophan, and threonine. These differences in treatment strategies are based on clearly different theories regarding mechanism of action. Consequently, more in-depth studies are necessary to investigate the potential role, dose, and composition of LNAA in PKU treatment.
Competing interest
Francjan J. van Spronsen is a member of the scientific advisory board of Merck Serono S.A. – Geneva, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany) regarding treatment for phenylketonuria and has received grants of Merck Serono. Margreet van Rijn is a member of the Merck Serono European Nutritionist Expert Panel in Phenylketonuria.
Details of funding None.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


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text: Katy Perry ft Pav bundy- "Firework Remix" Dec 21, 2010 Published by Renj 0 Comment DOWNLOAD LINK: Katy Perry ft Pav Bundy – "Firework Remix" Filed under: Industry, Pav Bundy, Katy Perry, Pav Bundy Use Search above to search this site or use the google search bar below Custom Search Send your exclusive tracks, videos and interviews to firstname.lastname@example.com Categories Beef Behind The Scenes BLOG Classic Dance Downloadable Music Exclusive Music Freestyles ILLPATH Music Chynk Showtyme Outfitt Pav Bundy Show Swerv Swerv Industry International Interviews InTheBox Mixtapes news next up Politics Pop/Commercial Shows Sports streetwear Uncategorized underground Videos Archives March 2016 April 2015 February 2015 March 2014 November 2013 September 2013 August 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 August 2012 July 2012 May 2012 April 2012 March 2012 January 2012 September 2011 August 2011 June 2011 April 2011 February 2011 January 2011 December 2010 November 2010 October 2010 September 2010 August 2010 July 2010 June 2010 May 2010 March 2010 January 2010 December 2009 November 2009 October 2009 September 2009 August 2009 July 2009 June 2009 May 2009 April 2009 March 2009 February 2009 January 2009 December 2008 November 2008 October 2008 RSS Feeds NahRight? RSS Blogroll 2dopeboyz BuckMarleyXXX.com DatPiff Gallic Wars iGet@Em The Magazine Illpath Myspace Illpath Studios Illpath Torrents InTheBox NahRight OnSmash SamHoody.Com Sermon's Domain spityourbestverse.com StreetwearScene.com Vlad TV World Star Hip Hop Xclusives Zone Advertise With US!!! Calendar December 2010 M T W T F S S « Nov Jan » 12345 6789101112 13141516171819 20212223242526 2728293031 Off Tha Presses!!! Swerv [Chynk Show] – Wake & Bake Ft. Pav Bundy "Hold Ya Head Freestlyle" – feat. Mr Prolific x JR tha Future x Swerv "Motivation" – Swerv {Chynk Show} (Directed By Da Inphamus Amadeuz) "Fire" – Swerv [Chynk Show] (Produced by Pav Bundy) Swerv – "So Faded" Hip Hop NewsBryson Tiller "True To Self" & Lil Yachty "Teenage Emotions" Sales Projections Are In May 28, 2017Will the teenager be in his emotions over the sales? XXXTENTACION Threatens A$AP Lotto In DMs Over "Look At Me" Beat May 28, 2017It goes down... Rich Homie Quan Arrested En Route To Georgia Concert May 28, 2017Fans didn't get the performance they were expecting. Meek Mill Warns NBA YoungBoy To Move Away From Baton Rouge May 28, 2017Meek's grim warning comes with bitter experience after the loss of his close friend, Lil Snupe. Starlito & Don Trip War With Post Malone Over "White Iverson" On Twitter May 28, 2017Cultural appropriation or nah? Album ReviewsReview: With "Ether," It's Time To Take B.o.B Seriously Again (Musically) May 26, 2017We cannot vouch for any "earth is flat" theories but that's not what this album is about.Review: KRS-One's "The World Is Mind" Does His Catalog Little Justice May 26, 2017The Blastmaster brings his raw energy and commanding presence on the mic and boom-bap, but has some missteps along the way to the inner mind's eye.Review: "bloom" Harvests Machine Gun Kelly's Best Work To Date May 17, 2017A shining example of artistic growth mined by personal troubles and emotionally resonating themes. Hip Hop Headlines Rumors TagsA-Wax Biggie blackhand Black Sun bundies butch green cassidy chynk Chynk Show chynk showtyme Da Inphamus Amadeuz DJ Drama don mamas radio F.A.M fred the godson french montana Grafh Green Lantern hema hip hop illburn illpath infared jadakiss Jamelle Bundy J Star Kaliba Masta Ace Mista Raja mozart outfitt Pav Bundy Q Boogie ruff ryders Show Swerv Showteezy Snyp Life sosh sosh b cardi Spot Styles P Swerv the bundies us or nuffin Young Berg Home/Studio Recording Info Watch the latest videos on YouTube.com Exclusive Content A-Wax & Chynk Show – Bricksburg Mixtape Hip Hop Hotties!!! (18 and Over)(Adult Material) ILLPATH RECORDING STUDIO Admin Register Log in Entries RSS Comments RSS WordPress.org Affilliates DISCLAIMER ILLPATH.NET Does Not Store Any Files Listed. Files Are For Promotional Use Only And Should Be Deleted Within 24 Hours.


text: Suppose you manage a small restaurant in mid-town Manhattan. In the morning, you run a campaign geared toward breakfast and during lunch time you run a campaign geared toward lunch. You would like to run the breakfast campaign only between 7AM till 11AM on weekdays and you would like to run the lunch campaign from 12:00PM to 4:00PM. Accomplish this setup using the Ad Scheduling feature in Google AdWords.


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No Gentleman for Georgina (The Notorious Flynns, #4)
€ 2,70
epub eBook
Sofort lieferbar (Download)
Mai 2015
Beschreibung* * * A hot historical romance from USA TODAY Bestselling Romance Author Jess Michaels * * *
Georgina Hickson has lived her life doing everything she is supposed to do in order to land the titled husband her family requires. When she met Paul Abbot at a gathering at a friend's, it was the first time she ever wanted more. But more is something she knows she cannot have.
Paul has been in love with Georgina since the moment he laid eyes on her two years before, but he knows he isn't good enough for her and it can never be. But when he finds out she desperately wants to see a special exhibit in London, he agrees to take her. But can a stolen moment, a stolen kiss and a whispered confession lead to happiness or heartache?
Length: NovellaSensuality level: Hot and steamy
This book can be read as a stand-alone story, but is part of a series (The Notorious Flynns).
Untertitel: Sprache: Englisch.
Verlag: The Passionate Pen
Erscheinungsdatum: Mai 2015
Format: epub eBook
Kopierschutz: Keiner


text:
So I'm thinking about getting a n7. It was either it or the Chromebook. So I chose the n7 cause its cooler. :p Anyways,I'm primarily going to be usuing it as a gaming tablet,and maybe some occasional paper typing. So I want to know how the tegra 3 processor fairs up to the n10's dual core one. I've been told the n10 has a better chip then the n7 but the nvidia chip has a more dedicated dev. team that makes games specificly for it. Any feedback would be appreciated thanks. :)
My one x is better then your one x!!


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CHAPTER: 4, (PRT 10) BUZZKILLMature
People parted way until they got to the bar itself. Alex lifted the counter and motioned for Derek to follow into the beach house. The only part of it that was unlocked was a small hallway cutting across the building leading to the bathrooms.
Alex tugged a necklace out from under his shirt, a keycard on the end of it. They both passed the bathroom doors and stopped at a door on the other side of the hallway. He swiped the knob and they stepped in.
The door clicked shut, and so did the noise.
It was unnerving. To Derek, it felt the same as what he guessed it would be like in a coffin.
"Father uses this room, to meditate he says." Alex shrugged.
Derek leaned against the wall, "is that what we're doing? C'mon man, I thought the festivities were outside."
Alex smirked, "You don't dance, Derek."
"I do! I'm an excellent dancer. We took dance for Gym class!!"
"Yeah! After I convinced you to join me for the babes!"
Derek laughed, "Seriously though, what's up?"
Alex took a breath, "You don't feel anything wrong at all? This whole thing with Clair, I mean?"
Derek rubbed the heel of his palm against his face, "Geeze man, I guess I do. But we both know this is a rare thing, right?"
"I just hope you put some thought into this."
Except Derek didn't want to. He held uneasy thoughts about it from the moment she entered his room in the hospital. Clair had made it way too easy, like it wasn't real.
Derek sighed, "You're right."


text:
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- Last year, Gonzaga lacrosse player Matt Borda scored an 80-yard goal that was featured on ESPN SportsCenter's Top 10 and also has more than two million hits on YouTube. Highlight credit: courtesy of Prominent Productions. ()


text:
Hi there
I have now had my BMW 535i for a little over 2 years and can still be surprised at how nice the car is and how well it runs.
You can see it here: BMW 535i
If you have any questions about the car please do not hesitate to ask.
Best greetings


text:
Come see what God is doing in the San Fernando Valley
Neighborhood Initiative and Life Connections International, two ministries dedicated to the cause of unity within the Body of Christ, announced today that their respective organizations would jointly serve as conference hosts for a special gathering of pastors and ministry leaders to be held at Bel Air Presbyterian Church on Thursday, September 13th. The one-day event has been entitled Neighborhood Initiative: Bringing Life to Our Cities, while the theme of the day can best be described as "The WHOLE Church taking the WHOLE gospel to the WHOLE city, one neighborhood at a time."
The conference will begin promptly at 9:00am, ending at 2:00pm. Over the course of those few hours, attendees will have the pleasure of hearing three very well known speakers: author and USC professor Dr. Dallas Willard; Pastor Jim Tolle of La Iglesia En El Camino ("Church on the Way"); and the always inspirational and well known author Joni Erickson-Tada.
Dr. Willard's message will address the Church's responsibility to a culture in moral decline while Pastor Tolle will focus on the central theme of the day . . ."The Whole Church Taking the Whole Gospel to the Whole City". After a brief lunch, Joni Erickson-Tada will address the subject of compassion as being at the heart of what motivates the Church to action.
Through Neighborhood Initiative, local congregations are encouraged to engage their individual neighborhoods through simple acts of love and kindness. To date, over twenty churches in the San Fernando Valley have joined together in an effort to reach the entire Valley with the message of Jesus' love for mankind.
Attendees of the conference will have the opportunity to hear from Lynn Cory, founder of Neighborhood Initiative and Associate Pastor at Valley Vineyard. Also addressing the group will be Jeff Fischer, pastor of Hope Chapel of the Valley, and coordinator of the Neighborhood Initiative movement currently taking root in the San Fernando Valley.
Bel Air Presbyterian Church is located at 16221 Mulholland Drive, Los Angeles 90049.
For more details concerning the event, please contact either Tyler Lennon (firstname.lastname@example.com) or Lyle Randles (email@example.com), both of Life Connections International.


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We all play a very important role.
Yes, yes, yes.
She announced that she will perform a benefit concert in Manchester for the victims and their loved ones
Every day's a school day.
For those who just can't deal with the heat.
They're getting more milk and less sugar
This may be the reason your periods have stopped
"It just makes me feel very, very uncomfortable because we're watching them become richer and richer..."
It took her 6 words to destroy a world leader. Succinct, no?
Sarah Ashcroft: blogger, social influencer, fashion designer, campaign face - here's how she did it.
With good reason, TBH
Someone hand us the bottle asap
Can someone stop this ride, we want off
She says "fancy" Cannes life isn't for her
So many pretty dresses
Don't try to fix the unfixable.
Is he more of a Tobias Funke or a Clark Griswold?
Turns out orgasms are like a fine wine...
That face palette tho...
Queen of Disney original songs.
Harper Beckham, Blue Ivy and North West have some serious competition.
'It's going to be the sexiest Love Island ever'
Greater Manchester Police said they had informed all the families of those killed
This role is perfect for her.
It's just what the couple needs after hosting the wedding of the year.
...Have they always been like this?
Fifteen-year-old Abigail shares her story of surviving the suicide bombing at Manchester Arena.
Any takers?


text:
Horned God Outfit
4,927pages onAdd New Page
this wiki
this wiki
|This vanity item is found only in the console version(s) of Terraria.
|v Horned God Outfit
|Vanity Item
|Body Slot
|Helmet/Shirt/Pants slot (Full set)
|'Remnant of an age of wonders'
|Dropped By
| Skeletron Prime (Mask)
The Destroyer (Robe)
The Twins (Boots)
|Drop Rate
|Sell Value
|No Value
The Horned God Outfit is a console-exclusive vanity set that consists of the Horned God Mask, dropped by Skeletron Prime, the Horned God Robe, dropped by The Destroyer, and the Horned God Boots, dropped by The Twins.
- It is a reference to the "Horned God" unit in the Age of Wonders series, as shown by the tooltip.
- The outfit looks a lot like Loki but with different colors.
Update Info
- Added to the game.


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A Genius of the Web
October 23rd, 2007 | Published in Google Orkut
Communication, social interaction, networking – these are concepts and experiences as old as the mountains but something here seems to indicate that the times they are a changing! When orkut was recognized as the MTV Youth Icon of 2007 a couple months ago, it was a great testimonial from the youth of India as to how much the spirit of free expression and exchange really means to them. But if some thought that 'smells like teen spirit,' here comes another testimonial to orkut and this time it's not just the users but a panel of experts who have bestowed on orkut 'The Genius of the Web Award 2007' as the best Social Networking website in India.
Genius of the Web is a series of awards instituted by Web 18 that recognizes industry achievements in the online space. But ask us who the award really goes to and where the kudos really belong and our unchanging refrain will always be – You. No wonder then that the evening of the award ceremony turned doubly special when two orkut users, randomly selected from amongst all you great guys and gals to represent the whole of the orkut community, actually went up on stage to receive the award. Prashant Saxena, an IIT Chennai student who has used orkut to build awareness of his NGO especially flew in from Chennai to be part of the ceremony and flew back post midnight to catch his class the next day! Meera Damji, a young advertising professional from Mumbai who has connected with the fringes of her extended family and over two hundred former classmates and friends through orkut joined Prashant in receiving the award, against a tight deadline at work the next day. That's the spirit of orkut users – all would agree!


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Below are a selection of hotels and resorts that we recommend in the Maldives. Our dedicated team have hand picked the best resorts for your Maldivian holiday, each one of them has been visited and we are available to answer any questions you may have.
Small, yet perfectly formed, sums up the beautiful Baros – a tiny picture-perfect island floating within the North Malé Atoll. Getting there is easy – it's just an exhilarating 20 minute speedboat transfer from the airport. This exceptional island is a Maldivian original and she recently celebrated her 40th birthday. Having undergone a total rebuild a few years ago, Baros is looking sensational. One of the things we love most about this intimate resort (and there are a few reasons) is the devotion of the staff – many have been with Baros for many years and we have to say you would be hard pushed to find a resort that offers a more genuine service than the one that awaits you here.
Niyama definitely tops the cool list! It offers a cutting edge take on the traditional Maldivian experience and with trend-setting twin islands, Play and Chill, you can double your pleasure too!
Say the word 'Maldives' and instantly Robinson Crusoe-esque visions of gin-clear iridescent water lapping the shores of tiny atolls flung like a child's necklace across the ocean spring to mind. It can be a minefield selecting the island that fits your own personal wish list but if it's an exquisite isolation, far from land with nothing but the hypnotic waves of the ocean around you, then Six Senses Laamu could quite possibly be your very own heaven on earth. In the virtually uncharted territory of the Laamu Atoll, this stunningly understated resort is hidden deep in the Indian Ocean towards the far southern reaches of the Maldivian archipelago. The location does mean it takes a little longer to get there but trust us when we say it is worth every single minute of the journey.
Arrive via seaplane for the hidden island paradise of Anantara Kihavah Villas. Located in the blissful Baa Atoll, an area of natural excellence recognised for its exceptional harmony between man and nature, this eco-friendly resort works hard to protect the irreplaceable natural beauty that surrounds it.
Situated in the unspoilt Noonu Atoll, a 40 minute seaplane flight north of Male, Cheval Blanc is a lush exotic haven offering exclusive accommodation and personalised service. The Cheval Blanc experience begins from the moment you arrive and you will have use of the private seaplane lounge whilst you wait for your onward seaplane. You can opt to travel in style on their own branded seaplane which offers an enhanced level of comfort with just 9 comfortable leather armchairs and exclusive amenities.
Arrive by speedboat at Bodu Hithi, which is naturally beautiful with mature indigenous vegetation and sandy walkways. The island is edged by white sand beaches and coconut trees and surrounded by turquoise seas and isolated sand banks.
A gloriously stylish Indian Ocean outpost, COMO Cocoa Island blends effortless cool with designer chic to offer an extraordinary island escape. Pristine caster sugar sand and swaying palms surround this tiny island refuge which can be circumnavigated on foot in only 10 minutes. To the west of the island lies the Kandooma Channel, widely regarded as one of the best dive sites in the Maldives, whilst opposite, a pristine reef entices those who favour a gentle snorkel. This is the tropical island fantasy of your dreams!
COMO Maalifushi is a new island concept from the luxurious COMO Hotels and Resorts. The island, located in the sparkling turquoise waters of southerly Thaa Atoll, features a mixture of garden, beach and overwater categories.
Floating gently in the North Ari Atoll, this elegant island escape is seriously stylish and part of the prestigious Constance Hotels and Resorts and The Leading Hotels of the World collection, sitting in company with the Indian Ocean icon Constance Le Prince Maurice in Mauritius. The glorious position is just a 25 minute seaplane journey from the airport – a truly fabulous experience giving you a birds-eye view of what awaits below.
All-inclusive laid-back luxury by seaplane! Nowhere does this better than Constance Moofushi in the South Ari Atoll in The Maldives! Rustic barefoot-chic simplicity is the order of the day here. All-inclusive has a 'Cristal' label ..and includes everything from your Beach or Water Villa to premium drinks, cocktails and an extensive wine list to the well-stocked mini-bar, daily changing menu with ocean views, guided snorkelling, a boat excursion and even an introduction to scuba diving in the pool.
Finolhu is one of a kind in the Maldives. Having only just opened its doors it is the new trendy kid on the block. Offering a retro inspired luxury island with a sophisticated beach club haven where timeless chic meets unchanged beauty. This vibrant new resort, located in the Baa Atoll brings a fun-loving beach vibe with top DJs, live acts and chic parties.
Four Seasons Resort Maldives at Kuda Huraa boasts all the charm and intimacy of a traditional Maldivian village combined with the exclusivity of a glorious private coral island setting.
This stunning island is located in the Baa Atoll, a UNESCO World Biosphere Reserve, just 30 minutes by seaplane from Malé. Expect pristine idyll meets polished luxury in a wild, natural setting of outstanding beauty. With pure white beaches flanking a sparkling lagoon, Four Seasons Landaa Giraavaru sits amidst 44 acres of unspoilt wilderness.
Offering the ultimate in understated Maldivian luxury, this acclaimed hideaway has been wooing honeymooners and those with a yearning to discover their inner Robinson Crusoe for years. For sheer romance, Gili Lankanfushi is hard to beat. Picture a perfectly still lagoon dotted with villas, threaded together by weathered jetties in the North Malé Atoll... This is the original 'no news, no shoes' concept, where you can spend your days happy and barefoot, as nature intended!
Chic, hip and happening all encapsulate perfectly this luxury retreat which is an exhilarating 30minute speedboat journey from Malé. Huvafen Fushi sits in a picture-perfect lagoon of sheer turquoise, banded by the deep indigo of the ocean beyond – this is fantasy desert island bliss.
Maldives promises a true insight into luxury island life. This family friendly and naturally beautiful resort creates an unforgettable playground for both adults and little ones, and at 2km long and 400m wide, is one of the largest islands in the Maldives.
This small intimate island has opened a new chapter in The Maldives for romantic barefoot informality. A haven for honeymooners and couples, Milaidhoo offers a refreshing contemporary twist on classic Maldivian style. Serious foodies will love it too!
This stunning resort is the original grand-dame of the Maldives and oozes luxury, sophistication and elegance. This is where you head for subtle beach glamour rather than a barefoot vibe – a favourite amongst the celebrity crowd; you can expect the ultimate in luxury and service. Arrival is aboard a luxury yacht that takes 75 minutes from Malé.
Amidst the exotic turquoise hues of South Male Atoll lies the tranquil island of Maadhoo; home to OZEN by Atmosphere at Maadhoo. Spread over an expansive turquoise lagoon the island features 41 beachfront Earth villas, idyllically positioned on a soft & pristine sandy beach, overlooking the horizon.
Far, far away there is a tiny dot in the ocean, less than 35 miles from the equator. This magical speck is in the middle of the untouched Gaafu Alifu Atoll in the southern reaches of the Maldives. It takes a little more effort to reach a place this pristine but believe us when we say the journey by domestic plane and speedboat is worth it. The atoll is home to more than 150 islands but only 10 of them are inhabited, this is a truly extraordinary Maldivian hideaway that might just be the heaven on earth!
The original Robinson Crusoe retreat in the Baa Atoll (superb for diving and snorkelling) and whilst only a 25 minute seaplane flight from Malé, Soneva Fushi's stunningly remote location is a major factor in its appeal. Speak to the 'Maldivian regulars' and without question they will tell you that this is a legendary resort which harnesses the very essence of a castaway idyll.
Sail around the atolls like never before and explore the Maldives on board your very own private boat charter whilst experiencing ultimate luxury! Soneva in Aqua is a unique private yacht experience offering the iconic services and amenities you would receive when staying at Soneva Fushi but with the freedom of sailing around the atolls with an itinerary tailored to your very own requests. Enjoy your own sun deck, Jacuzzi, on board spa treatments and incredible diving.
The Soneva story continues with Soneva Jani, the brands newest resort offering which opened in November 2016. Located in the Noonu Atoll, the resort comprises of five islands, the largest of which is 150 acres in size and is covered with lush tropical greenery and inhabited by land crabs! The highlight is the 5.6 kilometre private lagoon with its gin clear waters and pristine beaches.
Located in the south on Falhumaafushi island, The Residence by Cenizaro's fourth resort is definitely in keeping with the group's world-renowned colonial sophistication. Part of Leading Hotels of the World, this resort is stylish and effortlessly elegant rather than trendy or quirky and if you are looking for a true Maldivian experience, we think this is one of the best.
This beautiful island is only 25 minutes by speedboat from the airport and seamlessly blends minimalist, contemporary chic with the natural beauty of its surroundings. Velassaru, part of Small Luxury Hotels of the World, offers sophisticated, stylish and affordable chic luxury accommodation. The recently refurbished and distinctly Maldivian villas focus on elemental colours, local architecture and invoke a feeling of space and comfort.
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Jumby Bay – Antigua
The Rosewood mantra, 'A Sense of Place', couldn't be truer to its word than through the unique experience on offer at Jumby Bay, a private island paradise just two miles off the north east coast of Antigua. Nothing is impossible for the Jumby Bay team and their welcoming Caribbean charm is sure to make you feel like one of the family, from the moment you arrive until long after you leave.
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text:
super sixes
Who doesn't love a list? These are our pick of the best events from beginner triathlons to the toughest 10k's.
Winter doesn't mean that you should stop riding, so we've put together a sportive that will light up your imagination, fill you with Christmas cheers, and keep you riding deep into the full grip of winter. With a short ferry ride from the mainland, mince pies, indoor feed stations, and hot drinks, this is an end of season must!'.
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Some of the smaller (and not-so-small) brands making good stuff for events like this:
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text:
HOUSTON (AP) Texans owner Bob McNair will meet with coach Gary Kubiak on Monday to assess what went wrong this season.
On Sunday, the spotlight belonged to Arian Foster.
The undrafted free agent ran for 180 yards to win the NFL rushing title, and Houston ended Jacksonville's slim playoff hopes in a 34-17 win over the Jaguars.
BOX SCORE: Texans 34, Jaguars 17
Foster finished with 1,616 yards rushing, the highest single-season total for an undrafted player. He also had 604 yards receiving to become the sixth player in league history to reach 1,500 yards rushing and 600 yards receiving in the same year.
"In this lifetime, sometimes things don't go your way and you can take two roads," Foster said. "You can fold and quit or you can follow your heart and do what you know how to do. And that's what I did."
But Foster lamented that his numbers never translated to victories, mostly because Houston's defense was so bad. The Texans (6-10) matched their worst record since 2006, Kubiak's first season.
Outraged fans have been bombarding local sports radio talk shows for weeks, calling for Kubiak to be fired. Kubiak shot down a media report that he was coming back and McNair had signed off on any personnel decisions.
"That's not true," he said. "I had a couple of talks with him (McNair) this week. But the bottom line, I asked him the last time I talked to him, was to let me enjoy the week. Let me coach. Let me coach this game.
"So he's been fair to me and we'll make that decision (Monday)."
McNair was not made available for comment.
The Jaguars (8-8) may have some decisions to make, too. They needed a victory and a Colts loss to Tennessee to make playoffs, but couldn't overcome the absence of their top two offensive players.
Trent Edwards (FSY) started at quarterback for David Garrard (FSY), who underwent finger surgery Thursday, and Rashad Jennings (FSY) rushed for 108 yards in place of Pro Bowl running back Maurice Jones-Drew (FSY), who sat out with a right knee injury that will require surgery this week.
The Colts wound up winning minutes after the Jaguars' game ended.
"There are no excuses for it," cornerback Rashean Mathis (FSY) said. "As a group, collectively, we dropped the ball. To drop three straight, it's very disappointing."
The stumbling finish raised speculation about the future of coach Jack Del Rio, who's 20-28 over the past three seasons. Del Rio brushed aside a question about his job status.
"I am only concerned about that continuing to be a lead idea for your stories," he told a group of reporters. "Other than that, I'm OK."
Matt Schaub (FSY) completed 18 of 22 passes for 253 yards and a touchdown. He's thrown for 9,170 yards over the past two seasons, becoming the sixth quarterback to reach 9,000 yards passing in a two-year span.
But the star of Houston's season was Foster, who burst onto the scene when he ran for 231 yards in the opener against Indianapolis and racked up eight 100-yard games.
Foster talked all season about playing with a purpose and showing up skeptics who passed on him in the 2009 draft. He feels like he has more to prove next year.
"I guess that gives me a reason to work in the offseason," he said. "But I feel like you're never perfect as a player or a person because you're always working towards it. So I guess I've got to set some new goals."
Foster took the suspense out of the race for the rushing title on his first carry, a 56-yard burst on Houston's third snap. Foster came into the game trailing Kansas City's Jamaal Charles (FSY) by 32 yards and leading Tennessee's Chris Johnson (FSY) by 111.
Foster finished the opening drive with the first of two touchdown runs.
Foster embraced Kubiak when he walked off the field after his final carry with 1:54 left. He hugged Schaub and most of the starting offensive linemen as the final minute ticked off the clock.
"It's always nice to know that the people around you and the people who have been playing this game and been in this business for 20-plus years, they respect your game and they respect what you're doing," he said. "It's a good feeling. I wish we could have got some Ws to go along with it."
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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text:
This is Being Evel and you are watching CineRill
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Genre: History, Documentary
Evel Knievel
George Hamilton
Johnny Knoxville
Daniel Junge
Duration: 100 min
Quality: HD []
Release: Jan 23, 2015
IMDb: 6.5
Without Evel Knievel would we've been treated to such popular events as extreme sports, such shows as Jackass/The Dudeson's and would we've had superstars like Johnny Knoxvill
e, The Crusty Demons and a range of other noteworthy names pushing the boundaries of what's expected from performers and athletes? It's an intriguing question and one that filmmaker Daniel Junge looks to answer in his by the books but insightful examination of Robert Craig Knievel's aka "Evel Knievel" rise and fall.
Produced by Jackass lynchpins Johnny Knoxville and Jeff Tremaine, Being Evel is a clear love letter from the two gentleman and in particular Knoxville who was inspired by Knievel as a child so much so that he became the household name he is today. Knoxville spends time in front of the camera speaking about Knievel's impact on his life and the admiration he has for him shines through but Junge's trump card is the amount of Knievel acquaintances he manages to round up to talk intimately about the performer who pushed himself and pushed away those he loved with a prickly, womanising demeanour that eventually drove him off the edge.
Being Evel shows a clear divide between the Evel the thousands upon thousands of crowd members saw and the one that operated behind closed doors and those who believe Evel to be a lovable American flag waver will be shocked by some of the man's behavioural tendencies from an explosive temper, unfaithfulness to his loved ones and desire to push himself no matter the physical or mental costs.
Utilising the talking heads with ample archival footage, Junge collates everything into a clearly decipherable manner but the documentary never strays to far from its TV like roots and there are moments throughout the film where the interest levels will waver but there always bought back around again with Evel's next outlandish actions never too far away.
In the age in which boundaries are being pushed daily through professional and more Youtube like ways, Evel Knievel's antics may now seem a little "so what" but there's little point in denying that his the granddaddy of the showmanship and conceptual ideas of the modern day extreme athletes and performers. Being Evel is a must watch for Knievel fans and an insightful (if overly workmanlike) event for us bystanders.
3 blinged up walking canes out of 5


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Allen & Overy is pushing ahead with the introduction of personal time plans for all its lawyers, despite earlier opposition from associates over new targets exceeding 2,000 office hours.
Susan Howard, A&O's managing partner for corporate in London, has moved to reassure her associates that the new targets will not be linked to salaries or bonuses.
A memo also stressed that associates would be able to tailor the generic department plan to reflect their own roles. The development of personal time plans forms part of A&O's appraisal cycle.
Employment, pensions and incentives (EPI) associates raised concerns when they were asked to record an extra 500-600 office hours on top of chargeable targets of 1,600-1,700, taking them up to a total of 2,200 hours (The Lawyer, 18 August).
Corporate targets are slightly lower. The suggested breakdown is for middle-ranking associates to spend a total of 2,175 hours on firm business, comprising 1,700 billable hours and 425 on other firm business. Senior associates have a target of 2,195 hours, including 1,700 billable, and partners 2,400.
Jonathan Bond, head of HR for corporate, said: "We asked associates what communication was needed. They asked for further dialogue to be conducted within each individual practice group."


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