text:
An Ice-Scream Kamikaze Raved into Mortality 2Mature
I glanced the adhered raindrops on the other side of the window. It reminded me that the city was showered heavily all night long. I could have got back to the bed and continued to dream if the temperature had not been so breezy.
Alas, I couldn't retrieve back my sleep once I had woken up, as if there was something memorable that day. I could recall the day but I couldn't exactly remember what the event was. It was just like something dazzled on my reverie, or someone whispered to my ear.
I switched the TV on so that I was able to forget this buzzing mind. I actually enjoyed the morning reality show until someone who held a sword barged in my room. It seemed that it was a male, but it could also be a female due to its silhouette.
"Hi Mayu." It approached me closer and closer with a dark, raspy voice.
I yelped, "Aah… Monsters." The creature turned terrifying as it drew nearer to me.
"Hello, it's me, VY2."
I threw the pillow to him, shooed him away, and swore, "Simpleton!"
"I don't mean to—"
"To what?"
"—I just wanna say something to you."
"Yeah," I prejudiced, "you wanna confess your love, huh? How many girls do you have right now?"
"I don't mean to—umm—do such as dirty-minded things; I just need to say something important right now."
I ordained, "Give me a hundred pushups or I'll call the police,"
He received the punishment once I grabbed my phone and turned off the TV. I asked him cynically, "What do you want to say?"
"I just wanna say that today is his birthday, bu—"
"Hold it," I paused his punishment and it was that memento that I could have forgotten. "Oh, I get it." I got up from the bed and tidied the room.
"You mean him?"
"Don't tell me that you've forgotten his birthday. It's just so special because he entered to this mansion at the same date as he was born."
"Ah, I know right—"
"Don't mention his name. Let's ostracize him for the rest of the day until he treats us something."
"—Okay, thanks anyway. Now, get out from here before I change my mind!"
I opened the window; the sun shone so radiantly. However, the garden wasn't very moist after the midnight shower outside, so it was the suitable moment to plant my tomato seed. I swept and mopped the floor, and left the room without closing the door.
It was just a mediocre day because everybody did the same errands and activities—watching TV, gardening, recording the voice for the voice bank, writing lyrics, eating, and something ordinary, until…
"Special ice cream. Get a special discount just for today!"
The ice cream truck promoted its exclusive millennium-edition ice cream. Although it was quite distant to the Vocaloid's mansion, I could hear the crowds as if they idolized an artist singing on the stage. Kaito sprinted from inside and caught the truck up.
"Ice cream!"
"Whose voice was that anyway?" Big Al warmed up with Oliver and Yohio before jogging around the mansion.
"I don't know," Oliver replied, "maybe another boring ice cream truck passing nearby the mansion, again."
"This time, I'm going to retaliate him for he had implicitly molested me in the living room. Let's tail him."
I was just so inquisitive what was going on with that ice cream truck; not so many people queued up for the ice cream. Calling IA and Gumi, together we caught up the ice cream truck. It would be so fresh after swallowing a scoop of ice cream during the prompt haze.
"What, Mayu?" IA yawned, "I'm so sleepy. I wanna have my bed right now."
"There's an ice cream truck," I offered them.
"I'm sorry, but I'm not interested," Gumi refused, "unless there's a specialty"
"It is, Gumi. Let's go!"
Gumi grasped IA's hand and hauled her body with my help to the truck. Nonetheless, IA was still idling as she had been worn out after cleaning her kitchen all by herself yesterday. She held and hugged the big mango tree as we pulled her to the truck.
"I don't want to—"
IA gasped, "I just need some sleep."
"Let's go IA," Gumi bargained, "don't you remember your doctor's advice?"
"What advice?"
"Don't you forget that you'll squirt your bloody diarrhea on your joints if you sleep more than 10 hours?"
"But I was just getting asleep for nine hours, not ten."
"I don't give a care. Bite some ice cream." I tweaked her ear and pulled her tangled, wavy hair.
"No way!"
Gumi and I grabbed the shovels and stabbed on IA's buttocks, "Yes way! Come on."
"Oh gosh, not today—" IA rued.
Gumi and I dragged her like a toddler cart. We drabbled her onto the uneven road, tripped on the steep pedestrian, and scratched to the asphalt.
"Ow, ow, ow, ow, ow, ow, ow—"
As we reached to the ice cream truck that stopped near the emergency court, we wrecked up IA's entire fine body. Her face was as if she got smashed by the street gang. Her injury limbs were swollen so badly. Her hair was completely tangled. She clamored, "Merciless you both. I've just recovered my legs few days ago."
Oliver, Big Al, and Yohio turned backwards and offered IA for a hand.
"What's going on with you, IA?"
"I've just got drag—"
Kaito suddenly cheered raucously, "Ice cream!" Everybody turned and glared at him with intimidation.
"Huh? What's that guy doing there?"
"I don't know…"
"Yeah, who cares about the one who dyes the hair blue with cosplay suit during this haze?"
We were in the last of the queue whilst Kaito, Big Al, and the others were in the second last queue. The customers were lunatic like an army of ant arguing for the food stock. They pushed each other as if they were in the crypt and yelled each other as if they demanded a vociferous revolution to the current government.
"I want that ice cream,"
"No way, I'm going to grab his ice cream."
"Bitches do not eat anything but bones. You all are bitches, so I am the only one who legibly bite the ice cream."
"If we're the bitch, you're the son of the bitch. Hence, you are our son; you have to be obedient and not to show your pretentious personality to your mother, bitch!"
"I don't swear such things as bitch, but could you please take your words back? There are some naïve children who shouldn't listen to such profanity. Two hundred dollar, please!"
"You're the bitch, you're the son of the bitch, you're the son of son of the bitch, and you're the son of the son of the son of the bitch. Don't let me throw you bitches with your bitches to the beach where there are so many bitches lying on the sand beaches."
"Why don't we stop talking bitches and start the manly fight instead, bitch?"
"Can you guys stop saying bitch?!"
The crowds turned into a fraternity fight, where the mob members quarreled each other. They smashed, brawled, smacked, and assailed each other and created a walkway riot. At the same time, Kaito instantly cut the line left by the customers and talked to the ice-cream man.
"Welcome to the Ziti Ice Cream Truck!"
The ice man gazed at him and cued that he had known him before, "Have I known you?"
"I don't know," Kaito shrugged his shoulder as he paused, "maybe. Anyway, can I have an ice cream?"
The riot stopped and gaped Kaito. The silence entered as he took his wallet and the customer's sight gradually became more cynical. The ice man sweated in angst and dropped his ice cream that was going to be given by Kaito.
The customers who created the riotous atmosphere dismissed in all of sudden. We didn't understand what had just happened.
"W-w-w-w," I stammered, "…why the heck did the riot suddenly stop?"
"I don't get it," Oliver confused, "and why does the ice-cream man look so insecure?"
I saw a crowd of people bringing a big banner from my far sight. They seemed to be heading to the emergency court. As they arrived just in time exactly in front of the emergency court, they began to embroil the walkway. One thing surely unusual was that the mob undoubtedly consisted of the customers. I slowly read the banner and the phrase 'No cutting the line!' colored in brilliant blue and crimson.
"What's going on?" I calmed the mob.
"He's cutting the line, duh," the leader of the mob yelled to us with his loudspeaker.
"But you all are the one who left the line," we defied him.
"Yeah, I don't care. He's just cutting the line," one of the mob spoke firmly.
The leader commanded, "Go get them and the ice cream truck!"
The ice-cream man was stagnant as if he was chained so tightly that he was barely able to move. Big Al slammed the truck backdoor while Yohio and Oliver sneaked behind Kaito and kidnapped him. We all quickly intruded the truck.
"Are you okay, sir?" Oliver sensed the ice-cream man's forehead and reported, "His body is so cold like an ice cube. Is there anything we can do?"
Yohio turned on the car engine, and drove swiftly.
"Looks like the mob's going to form a commotion."
"Bwaaah! We're not even getting ready yet!" I screamed.
"Just look there. The mob's going to chase us."
Oliver fortunately unzipped his backpack and grabbed his hot green tea in a small, portable thermos. He took out his clean handkerchief, dropped some green tea on it, and compressed the ice cream man's forehead.
"Why do the truck move by itself?" the ice-cream man awakened.
"No time to explain," IA sighed, "now, drink the tea Oliver give to you. Just keep lying. Your body's too frigid."
He sipped the tea and replenished his power. "Are you okay, sir?" IA made sure that he was fine even the riot returned.
"Can you tell me what's just happened?"
"Short story, the mob is chasing your truck. Long story, your customers were just smacking each other, Kaito took over the line, the customers went home, and invaded your ice cream truck."
"Both of them are short story, in my opinion though," the ice man rasped, "and who's driving this truck?"
"Don't worry," Gumi patted his shoulder, "we have a competent driver here."
Looking at the window, the mob turned into a tumult that chased us impulsively.
"Hey, you blue hair! Don't cut my line!"
"No, you don't go anywhere. I'm going to haul you to the road, you blue-hair man!"
"My ice cream, where are you going?"
There was an old man who brought the grappling hook and he threw to the truck. I witnessed an old man shooting his grappling hook and attempted to brake the truck's right tire.
"Watch out!" we shouted.
Yohio successfully dodged the shooting hook. Nevertheless, the police convinced us controlling the car too rapidly; they chased us. The siren sound from the police car blended nuance to more chaotic.
* * *
The mob eventually dismissed their rebellion against us right before the police appeared in order to wipe them out; however, the police was just raiding us. We decelerated and braked the truck, halting nearby the big mansion. We exited the truck as we had already worn out.
The police car stopped and the police officers interrogated us, "Are you insane? It's too dangerous!"
"But there was a mass of mob chasing this truck," Oliver opposed.
"Mob? I didn't see even a single person chasing your truck. You've just violated the traffic law, you know."
"This is just for the sake of the ice-cream man," I explained as clearly as possible so that the police could comprehend what was actually happened during that jiff.
"I see," the police officer spotted Kaito near the ice-cream box. "Aren't you the one who cut the line and also harass Big Al?"
"I don't know," Kaito's naiveté rendered the police into the sympathy.
"Yeah, it's you. You're convicted for cutting the line!"
"B-b-but—" Kaito reprimanded.
"Tell to the EC later."
"—I have rights cut the line. They're leaving the line, duh…"
"It is still counted as cutting the line."
"Hey, police officer," Kaito brandished brutally, "although I'm not as adequate as my kin, Gakupo the lawyer, but according to the Civil and Human Right Book of Law Unit 10 Number 10 junto 10, it states that one does not violate the law when one cuts the line that has been left by the previous person. You don't have the right to accuse me!"
"You memorize the most complicated book from the Book of Law? It's ingenious, but you still have to pay me some money."
Kaito gasped as he gave up not having a sufficient argument to rebuke. "Huh, ok—"
"Hold on," IA interrupted, "you're bribing? I'm calling the EC right now."
"I'm bribing?" the police officer questioned to her, "It's not bribing, but it's a friendship payment."
"I don't care what the name is, but it still categorizes as a bribery. No bribery in front of my sight!"
She seized her phone and tapped the phone number impetuously.
"Okay, okay," the police admitted, "but still, it's dangerous to drive in such speed, kiddos."
Yohio showed his driving license from his wallet right in front of the police officer's face.
"Here's the license," he stood firmly, "think first before you call us kiddos."
The ice-cream man, who was still half-conscious, had a shufti around the mansion and he was just recovered without delay.
"Is that your mansion?" he stammered bafflingly.
"Not now, ice man," Big Al replied.
From my manifest sight, I saw a turquoise-hair girl rushing outside. I got involved to this problem and realized that the girl was Miku.
"IA, Gumi, Mayu, and everyone—except Kaito—what's going on here with the police?"
Kaito frowned because his name wasn't mentioned by Miku for three consecutive days ago—or four. I heard the rumor that both of them broke apart—rubbish.
As Miku commenced to negotiate with the police officer we were encountering to, from the emergency court, I could see that another police officer dashed to the mansion and seduced Miku.
"Miku-chan, weren't you the one who called me?" the police officer from the emergency court pouted his mouth, having a desire to kiss her, "Would you like to be my boyfriend? I'm single you know."
Miku turned her grin into a tempestuous fury. She punched, kicked, and strangled him as if she was eager to murder him.
"Take this!"
The police fluttered to the sky far, "Kyaaa!!! I still love you, Miku-chan!"
"Oh, that deviant guy. Damn!"
The police officer who asked us was totally nonplussed to us for what we had done to the police. Miku explained, "That's the police whom I called for an EC demand, but he's just neglecting me and instead, he molested me in such embarrassing way."
"O-o-o-okay?" the police officer was skeptical, "How can our talk be distracted with that police?" he paused, "I don't care anyway, but kids, just not to drive like just now, even if you have a driving license or you're on the errand. I have something more to do rather than minding this common problem. Chau chau!"
The police left the mansion and the ice-cream man thanked to us for helping him averting from the riot. But just then, he bestowed to all of us a cone of classical ice cream. Kaito clutched and licked the ice cream.
"Ice cream," he rasped, "more ice cream!"
The rest of us ignored from the beginning to the end—we acted as if he was a stranger on our unblinking eyes.
"Is he insane?" I asked Gumi as if he was just the one whom somebody I used to know.
"Who cares anyway?" Gumi jested, "Like, he's just barking all the time in the mansion. Bitch, a boy bitch."
Kaito approached to the truck and requested cones of ice cream for us. Gumi grumped, "…Fine, I'm taking all the phrases back,"
"Can I have some more ice cream for my friends?" Kaito asked.
He refused, "No—"
"B-b-b-but I just wanna treat my friends for today. I know you still have an ice cream."
"I have run out the ice cream, my idol."
"What? How can an untouched ice cream disappear in such eerie way?"
"You just ate the entire the ice cream during the riot, didn't you?" Oliver hoisted and toted the ice cream box and uncovered it, "Oops, I mean…" he disdained.
"Did I? The ice cream was doubtlessly delicious. I've never eat such ice cream in a huge—"
We were utterly staggered if the capricious Kaito entirely gobbled the ice cream; however, the ice-cream man still smirked to us for a vague reason. He opened the refrigerator door and grabbed some ingredients. He didn't chatter until he unsealed everything; he poured a bag of flour and some sugar, cracked some eggs, dropped few drops of vanillin paste, and added three glasses of milk. He mixed them until well-blended. He battered the pan with the mixture and baked perfectly.
I sniffed, "The scent's just like a sweet wet mooncake."
As the base completely toasted, he called us aloud, "This is the only exclusive homemade mooncake just for the Vocaloids. I guess this is Kaito's birthday, so this one is only for you. You can treat everyone with this free and the only one cake in this year. Just give it a try!"
Kaito stuck his tongue out and dripped his saliva from his watery mouth, as if the master fed him a dog food. "But not the way you act," the ice-cream man disgusted, "keep your water out of here first. I'm going to furnish this best mooncake I've ever created."
We all were attracted by the musky mooncake. He grabbed lots of toppings to garnish and decorate that mooncake. At first, he sprinkled a little bit sugar to enhance the sleek sweetness, then he spread some chocolate jam one third, followed by a third of pineapple and strawberry jam. He layered some chocolate sprinkles, shredded cheese, peanut chops, and banana slices.
Oliver flayed, "The iceman is surely obsessed with toppings."
Yohio opinionated, "The more flavors you put, the tastier it'd be."
"But that's too much," Oliver kvetched, "and you look him? He's taking another box of some kind of weird flavor."
He added few pinches of the flavor that Oliver witnessed. The herb was green and sort of blue, just exactly the same with the color of the cyanobacteria—I could perceive that it was an enhanced flavor containing single-cell protein so that the usage of the fat could be decreased drastically. IA peered at him skeptically, as if she was too frightened to be assaulted on his hand.
"What's that?" IA spewed, "It's just like poisonous antibiotic."
"Yes, it is an antibiotic." We were uttered in speechless.
"Seriously, you want a genocide towards us?!"
"Not that antibiotic used by pharmacists to cure a disease, nor tons of ecstasy extracted into a fake, generic medicine, duh…"
IA berated, "But it's hazardous to our health, you know."
"Oh, come on," the ice-cream man blandished, "it's just a simple antibiotic for extending the ice cream expires. It is made of edible cyanobacteria decomposing the chanterelles blended with vanilla extracts."
"B-b-but…" Gumi stammered.
The ice-cream man excoriated, "How can you still live last longer even if you have bought my ice cream?"
"Um… I think you have the main point," Big Al nodded.
The ice-cream man continued to sprinkle the some-kind-of-antibiotic stuff and flourished some more toppings.
"Are you sure that the ice man will garnish the mooncake with these odds and ends? Look at these rainbows, are we going to eat that mooncake with these sugary toppings?" Oliver was insecure because he had a moody diabetes, a very rare infection that the victim could catch a diabetes whenever the victim was overly emotional—not just anger, but also happiness, sadness, fear, worrisome, etc.
"What do you mean the rainbows?" Big Al asked, "I think he will serve that separately to us as a compliment."
The ice-cream man then sliced the rainbows defined by Big Al and Oliver and put just on top of the spread core toppings. I thought it was just nothing extraordinary because it was just the only one dish that was a signature.
Slicing the rainbows on top of it, he began to sprinkle some more flakes—chocolate, strawberry, rice crispy, and many more. The thickness of the topping layers were about half a span. Even worse, he even confused us by shredding not only raw carrots, but also boiled potatoes, white radish, and blended taros.
"Is he in the mind?" I baffled on puzzlement, "I mean, what the heck?!"
Although the rainbows and gardens covered the entire base, the ice-cream man hadn't finished furnishing the mooncake. He glazed the layers with the honey and coffee syrup and this time, he took something inside the oven. I was astonished because there should not have an oven even in the most modern and latest RV, but he had one, like there was a specialized stove installed inside the truck's engine. The scent from the oven was just so mild that I could get pampered by the whole smell. Suddenly in the truck, I heard a chopping sound and everyone was panic as the man was going to commit suicide.
"Eww," Miku spritzed, "is he abnormal? Why does he even try to suicide in the truck with his smile?"
"I don't know, but he's paranoid and he might turn us into androids," Gumi replied.
Suddenly, the man reappeared in front of us. He daunted us by pacing with his hands smeared with red liquids. The liquid was too condensed, even thicker than the blood of the most dangerous criminal in the world. As we peered carefully, he was actually handless, as if he minced his hand.
"That man is gross," Big Al felt a chronic nausea and vomited, "but he's just too odd."
"What?" I asked.
"Just look at him. He has just lost his hand, but he is able to lift the chicken for sure. Or maybe, am I in the world full of fantasy?"
We abruptly experienced the same nausea as Big Al felt after we had seen the man painted with dark crimson, but I managed to control my sickness with my venom in my radii. IA was totally comatose for temporarily because she had caught an asthma before she was ten. Gumi and Miku, in this case, stayed immobilize while the boys dropped their tears.
Then, the ice-cream man called us out loud after he flipped the other base and covered the toppings like hamburgers, "Vocaloid's, the special menu has just done. I call it The Tower of the Crypt Mooncake!"
"NO! It's just so disgusting you coat the mooncake with chicken blood, or maybe even your blood from your vena," we irked to the ice-cream man, except Kaito; his eyes starred as if he was going to immerse in the euphoria of the heaven.
"It seems like a vermillion blood, but it is not a blood," the ice-cream man rejected.
"But you've just lost your hand," Miku exclaimed.
"Let me guess, you think that I am going to commit suicide, don't you all?" he assured.
"But it's just—"
"No, no, no!" he grabbed a box of utensil and brandished us, "This is my automatic butler portable machine. It does really make the suicidal sound, but it is so convenient and affordable. You should buy this, and I ensure this kit won't hurt you. About my hands, I have never harmed myself just because of something desperate. It's the chicken sauce, and obviously that's not the blood."
"Still, it's just so awful to see in public place, isn't it?"
"No, that's just a flavor enhancement. I often cook the chicken with this sauce to my family and they don't even complain how dirty the food is because it really is a sauce. I put some blended red ginger, red rosemary extracts, and apple cider vinegar."
"You really want to poison us with vinegar?!"
As we vitriolled to the ice-cream man, Kaito divided the mooncake into small parts and we were all astounded as he chunked the eerie mooncake.
"No, Kaito! We're sorry, we won't let you die!"
He ignored us and swallowed the food. His cheek reddened and we were showered with white fear. According to the rule, whoever takes someone's life on purpose, he or she will be banished from the mansion for a very long time. That was just inevitable because we were undoubtedly the murderer of Kaito just because of a stupid ostracism.
His cheek was even more blushing than before; he was just beyond the euphoria—he was in the reverie where he could dwell there for eternity without any interruption.
"This is just so mild! It's a masterpiece!"
"What?" we couldn't react to Kaito's emotion.
"You're lying," Oliver was mouth-watering.
"Am I in the period where I have to imagine?" IA fazed.
"Kaito, are you drunk?" Gumi yelped.
"You should try this," Kaito ordained us, "call the others too! I'm treating you all!"
We were skeptical, but I eventually asked everyone to taste the weird mooncake made by the ice-cream man. We grabbed and ate the slice in unison. My inner feelings were changed in anti-clockwise. The smoothness, mildness, and delicacy of the mooncake was distinguishable with the other mooncakes. It was so consistence, even if he garnished all leftovers on top of the mooncake.
As we jumped so lightly that we were in the exhilaration, something mysterious pulled most of the member's body. The thing acted like a gravity force. Oddly, IA, Kaito, and I weren't attracted by the force. Gumi, Miku, and the others were shrieking in pain. The scream could reach for almost the entire city. Not only did they grieve and shriek so squeaky, but we were also smeared by the sweat in apprehension.
We hid in the truck and Kaito shut the window, fortifying the ice-cream man from the sound pollution.
"What's just happened?" the ice-cream man questioned us, "I've never seen this kind of affair before."
"I also don't know why the heck they howl." I peeped at them and the attracted force was even stronger than before; in comparison with the gravity—nothing. I was too anxious to their condition at the moment, so I got off from the truck.
"What's happening to me?" The oozy force attracted my body and even absorbed my power.
"Are you alright?" IA and Kaito got off from the truck and they were immovable.
"What kind of natural disaster is this?" the ice-cream man rued whilst he shut the backdoor. He stopped wailing after he saw some people walked at the affair nearby, "Fixed; this is so weird. Why don't they get pulled by the force? Is there something wrong with these Vocaloid members?"
The force quickly dwindled and we all could move again. Nobody put even a single comprehension after that flabbergasted affair passed—definitely.


text:
Dorchester students building mosaic of David Ortiz
Updated:BOSTON (MyFoxBoston.com) -- Students at the Joseph Lee School in Dorchester are working on a large mosaic of Red Sox slugger David Ortiz.
Sensory arts teacher Chris Hall tells FOX 25 the mosaic was built over a period of one month by 153 students with autism. The mosaic contains more than 32,000 small tiles.
The school hopes to unveil the artwork sometime this month.
This is just the latest mural created by the talented students at Joseph Lee. In 2012, they built a mural of President Barack Obama, Oprah Winfrey, Rosa Parks, and Dr. Martin Luther King, Jr. to commemorate Black History Month and Autism Awareness Month.
© 2017 Cox Media Group.

subset: commoncrawl


text:
Movie poster Brewster's Millions (1945)
En stackars miljonär
Poster 30x70cm nice condition FN original
Poster year:1945
Actors:Dennis O'Keefe
Find more:Money 30x70cm
4.0 / 5 from 13 ratings
Vintage Movie poster from a movie theater 1945. Rare, most were thrown away. Great quality in paper and colors, nice to frame on your wall.
Other posters you might like
All Hands on Deck (1961)
Pat Boone
Angela (1954)
Dennis O'Keefe
Rännstensungar (1945-82)
Adolf Jahr
Joan of Ozark (1945)
Joe E Brown
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Arrange the sections on this page to see the updates you care about most at the top. Or, use the Recent Updates view in the community navigation to view all updates by time.
Embedded Training Institute, Noida is a premier & the best Embedded
System Training institute in Noida provides training on Embedded
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All you need to know about tuition, fees, financial aid disbursements, financial policies, and financial deadlines at SDSU.
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And so the least surprising election result since Kim Jong-Il secured an unprecedented 27th term is now in. And, as expected, Rob Day is the new man at the helm of the good ship SJ Berwin (see story).
That said, Day saw off a tougher than expected fight from his corporate comrade Perry Yam, with internal sources suggesting he triumphed by just a handful of votes.
Now the firm can turn its attention back to the most tortuous merger process since Peppe Garibaldi got out a map of Italy and started rubbing out all the thick lines.
Day, who has some experience in the hot seat after being parachuted in while Ralph Cohen was on sabbatical last year, will be hoping that talks with Proskauer get resolved one way or another pretty soon. Otherwise the protracted dance of love might lapse into an embarrassing second year.
If the engagement goes on much longer the firm could be in danger of becoming the law's answer to Kate Middleton. And no one wants that, right?
In The Lawyer on Monday: Why Linklaters should be frightened of Freshfields; what Simmons is doing to improve its female partner stats; and how public sector lawyers are reacting to George Osborne's Comprehensive Spending Review. Plus: our exclusive report on diversity accross the top 30 UK firms.
Also on TheLawyer.com: BPP to train even more job-seekers; two heads better than one for CC's antitrust team; and why Willie the Wizard loves Blackstone Chambers.
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"Havana: Piercing the Darkness," Dec.7 - Jun.19 at Dalet Gallery
Dalet Gallery is pleased to present upcoming exhibition featuring photography by Susan Bank, Ilya Genin and Ron Tarver. Three artists present their vision of Havana, one of the most intriguing cities in the world.
Receptions: Dec 7, Jan 4, 5 – 9 pm
Three artists present their vision of Havana, one of the most intriguing cities in the world where renovated palaces coexist with colonial ruins, and the loss of opportunity is countered with seemingly unmitigated hope.
"To dare to interpret this tropical garden is a risky game. Photographers have come and gone before me and others will follow—chasing butterflies. " (Susan Bank)
"A risky game…" – however more and more artists visit Cuba, inhale its air and, intoxicated, come back there again and again relentlessly drawn by the magnet of instantly established highly personal relationships with this unique world.
The three artists presenting their works at Dalet are not competitors, for each of them multi-faced Havana unveiled its individual features. The exhibition thus, like a novel, consists of three parts, three love stories.
Part 1. "they have nothing to give but their soul in a cup of coffee…"
Susan Bank's romance with Cuba began in 1999 when she first time arrived at Havana, the city that later became an interlude for more then 20 trips to the "island in the shape of a crocodile." Trying "to get inside the skin of the real players," she lived in private homes in Centro Habana "waiting in long stationary lines in markets where there is nothing to buy, enduring sleepless nights interrupted by a chorus of barking dogs…"
And thus it came – "a desire to peel away the exotic veneer of Havana, to unveil the submerged realities of that illusive citadel."
"... I wait in shifty shadows for the invisible, where the real slips seamlessly into the surreal, where the mask of a smile is always for sale, and Cubans have nothing to give but their soul in a cup of coffee."
- Susan Bank
Susan S. Bank of Philadelphia PA and Portsmouth NH, educated at Barnard College and the University of Edinburgh. Known for producing long -term photo essays beginning with the Salisbury Beach series, she spent one seventh of her life from 1999 - 2009 working on the island of Cuba.
Bank has exhibited widely in the United States including the Gabarron Foundation, NYC, New York Photo Festival, the SouthEast Museum of Photography, Michener Museum of Art, The Print Center, Philadelphia, the Griffin Museum of Art, FotoFest, The Museum of Fine Arts, Houston, Blue Sky Gallery, Lehigh University Art Galleries, Danforth Museum of Art, MASS College of Art, University of Maine Museum of Art, Invision Masters with Sid Kaplan and Larry Fink. In Latin America she has exhibited at the Manual Alvarez Bravo Center, Oaxaca Mexico and several venues in Cuba, including The Fototeca in Havana and the 6th Habana Bienal.
Locally, selected awards included Fleisher Challenge Grant Artist, Perkins Center for the Arts Juror's Excellence Awards.
Selected national awards include "The Photo Project' juried by Anne W. Tucker and shown at Galveston Arts Center, FotofFest 2006; the Portfolio Project Prize by Rod Slemmons at Santa Fe Review 2005 (now The Center); and Aperture Portfolio Prize Runner Up. Twice she was a finalist for the Duke/Honickman First Book Prize.
Her photographs are held in museum collections, in the United States, Mexico, Spain, and Cuba, and most recently in the Center for Creative Photography, University of Arizona Tucson.
Presently exhibiting at the Michener Museum of Art in "Making Magic: Beauty in Word and Image curated by Brian Peterson, future exhibition at the Fototeca Nacional, Pachuca, Mexico, and a collaborated with Cuban artist/photographer, Juan Carlos Alom.
She works with a handheld Leica M6 using available light.
Part 2. "…the expectation of something good just around the corner…"
Ilya Genin succeeded in the attempts to capture the vibe he felt exploring the streets of La Habana Vieja and the complex emotions he experienced conversing in Spanish with the Cubans. For Ilya "Havana is about its people – their openness, generosity, dignity and the joie de vivre so palpable in most human contacts." Trying to emphasize duality: beauty and sadness, energy and lassitude, bluster and resignation, Genin makes a special accent on the spirit of anticipation, "the expectation of a change in the air, of something good just around the corner…." Where a straight photo is not enough, Genin uses collages to tell the story.
"If I succeeded, I credit the Habaneras for their warmth and kindness, for their light and sincere welcome.
If I failed, it is only because my visual language is too limited to describe my fascination with Cuba and its people."
- Ilya Genin
Ilya Genin started photographing while attending high school in Kiev, Ukraine.
His work in photography was interrupted by the Medical School and subsequent work as a physician, first in Kiev and then in the USA. Family obligations proved to be a diversion as well.
He is now splitting his time between the practice of Cardiology and learning the art of storytelling using the photographs and photographic collages.
Ilya's current passion is Cuba and his work on Havana and its people has won several awards from Black and White Magazine; this work was the subject of several solo shows and the book is in the works.
Genin leads the photography critique workshop at the Princeton Photography Club called U Get What U Pay For.
Part 3. " it is a wonderful contradiction…
For Ron Tarver, Pulitzer prize winning photographer, Havana is "lethargically energetic, immaculately filthy, an illusive illumination. It is a wonderful contradiction."
"For every answer given to explain Havana, there are dozen more questions. It is a society held together by ingenuity, floating on an outdated dream."
- Ron Tarver
Ron Tarver, received his BA in Journalism and Graphic Arts from Northeaster State University in Oklahoma, and has been a staff photographer at The Philadelphia Inquirer since 1983. In addition to his newspaper publications, his work has appeared in National Geographic, Life, Time, Newsweek, Sports Illustrated, and Black and White Magazine. He is a co-author of the book We Were There: Voices of African American Veterans, published by Harper Collins in 2004, which was accompanied by a traveling exhibition that debuted at the National Constitution Center in Philadelphia. He shares the 2012 Pulitzer Prize at the Philadelphia Inquirer for his work on a series documenting school violence in the Philadelphia public school system.
A recipient of the prestigious Pew Fellowship in the Arts, Tarver has also received grants from the National Endowment for the Arts, the Pennsylvania Council on the Arts, and an Independence Foundation Fellowship. He was named one of the Delaware Valley's "50 Rising Stars in the Arts" by Seven Arts Magazine and is an alumni of the Center For Emerging Visual Artists. Tarver offers private photography instruction, workshops, and photo excursions through his company, Photo-Ops, and serves as Visiting Assistant Professor of Studio Art at Swarthmore College.
Tarver's work has been exhibited nationally and internationally in over 30 solo and 50 group exhibitions and is included in many private, corporate, and museum collections, including the Philadelphia Museum of Art, the State Museum of Pennsylvania in Harrisburg, Oklahoma Museum of History and the National Museum of American Art of the Smithsonian Institution in Washington DC.
Dalet Gallery, 141 N 2nd Str, Philadelphia, PA 19106. Hours: Wed– Sat noon – 6PM and by app.
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text: I used Paragon Partition Manager 11 to make a clone of my "C" boot drive. "C" is the HDD in position 0. The clone is in position 1, which prior to the clone operation was "D". I am sure that if I removed HDD 0 and replaced it with HDD 1, the system would boot to Windows 7. (I have done this on an XP system in the past.) But, I wanted to try and boot the clone without having to physically remove HDD 0. I am pretty sure that any SATA HDD can be used to boot, not just the first in the chain (HDD 0). BUT, I haven't been able to get HDD 1 to boot. No matter what I try, HDD 0 continues to boot. I used Windows 7 PE to take HDD 0 offline, and then boot the system. The system placed HDD 0 online and booted it. Any advice or insight will be very much appreciated, Jim


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Differences in ovarian aging patterns between races are associated with ovarian genotypes and sub-genotypes of the FMR1gene
- First Online:
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- Cite this article as:
- Gleicher, N., Kim, A., Weghofer, A. et al. Reprod Biol Endocrinol (2012) 10: 77. doi:10.1186/1477-7827-10-77
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Ovarian aging patterns differ between races, and appear to affect fertility treatment outcomes. What causes these differences is, however, unknown. Variations in ovarian aging patterns have recently been associated with specific ovarian genotypes and sub-genotypes of the FMR1 gene. We, therefore, attempted to determine differences in how functional ovarian reserve (FOR) changes with advancing age between races, and whether changes are associated with differences in distribution of ovarian genotypes and sub-genotypes of the FMR1 gene.
We determined in association with in vitro fertilization (IVF) FOR in 62 young Caucasian, African and Asian oocyte donors and 536 older infertility patients of all three races, based on follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH) and oocyte yields, and investigated whether differences between races are associated with differences in distribution of FMR1 genotypes and sub-genotypes.
Changes in distribution of mean FSH, AMH and oocyte yields between young donors and older infertility patients were significant (all P < 0.001). Donors did not demonstrate significant differences between races in AMH and FSH but demonstrated significant differences in oocyte yields [F(2,59) = 4.22, P = 0.019]: Specifically, African donors demonstrated larger oocyte yields than Caucasians (P = 0.008) and Asians (P = 0.022). In patients, AMH levels differed significantly between races [F (2,533) = 4.25, P = 0.015]. Holm-Sidak post-hoc comparisons demonstrated that Caucasians demonstrated lower AMH in comparison to Asians (P = 0.007). Percentages of FMR1 genotypes and sub-genotypes in patients varied significantly between races, with Asians demonstrating fewer het-norm/low sub-genotypes than Caucasians and Africans (P = 0.012).
FOR changes in different races at different rates, and appears to parallel ovarian FMR1 genotypes and sub-genotype distributions. Differences in ovarian aging between races may, therefore, be FMR1-associated.
KeywordsOvarian reserve Ovarian aging Follicle stimulating hormone Anti-Müllerian hormone Oocyte yield FMR1 gene Infertility In vitro fertilization
anti-Müllerian hormone
diminished ovarian reserve
functional ovarian reserve
- het
- hMG
human menopausal gonadotropin
- hom
follicle stimulating hormone
fragile X mental retardation 1
- norm
in vitro fertilization
Institutional Review Board
standard deviation.
Evidence has accumulated over the last decade that ovarian aging is genetically controlled [1, 2], and that significant differences can be observed between races/ethnicities [3]. These differences also appear reflected in varying infertility treatment outcomes between races [4, 5], though some investigators have disputed such differences [6].
We recently described ovarian genotypes and sub-genotypes of the FMR1 gene, which have been associated with varying ovarian aging patterns [7, 8] as well as differences in pregnancy chances with in vitro fertilization (IVF). They are based on a normal range of CGG triple nucleotide repeats (CGGn) of 26 to 34, with median of 30, allowing for the determination of genotypes and sub-genotypes of FMR1, distinct from traditional genotypes, which are primarily used to assess neuro-psychiatric risks [3, 8].
In a study of 339 infertility patients we previously demonstrated that different races were associated with different distributions of FMR1 genotypes and sub-genotypes, and that genotypes and sub-genotypes in different races were associated with varying IVF pregnancy chances [3].
It now occurred to us that differences in ovarian aging between races/ethnicities should be reflected in cross-sectional observations of functional ovarian reserve (FOR) over time. FOR represents the part of total ovarian reserve that, to somewhat varying degrees, can be evaluated by follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), and oocyte yields in association with in vitro fertilization (IVF), and has been equated with "ovarian age" [9].
Consequently, if different races age ovaries differently, they over time should demonstrate divergent FOR. In an attempt to further clarify what influences variations between races in ovarian aging patterns, we in this study present such a cross-sectional study over time, by comparing FOR in young oocyte donors and older infertility patients of different races, and by associating their FOR changes with FMR1 genotype and sub-genotype distributions.
This study assessed 62 first oocyte donation cycles in young oocyte donors and 536 first IVF cycles in infertility patients. The study, thus, compared cross-sectionally a young egg donor population with a significantly more aged patient population. Individuals in both patient groups were classified by race/ethnicity in accordance with NIH guidelines [10] as Caucasians, Africans and Asians. Asian patients almost universally were of Chinese descent. Because Hispanic patients often cross racial/ethnic identities and are under NIH guidelines, therefore, defined as "ethnicity" rather than race, they were excluded from consideration, as were other patients of mixed racial/ethnic backgrounds, unless they self-identified as belonging to one of above three specific races.
As reflection of FOR, we for all patients assessed FSH, AMH prior to cycle start, and oocyte yield at time of oocyte retrieval. FSH and AMH were assessed by routine commercial assays.
All oocyte retrievals were performed by two of the authors (N.G, D.H.B.), who in over eight years of continuous quality control never differed in number of oocytes obtained during oocyte retrievals. Variations in oocyte numbers retrieved between physicians have been suggested a limiting factor in using oocyte yields as the most accurate representation of FOR [11].
Patient characteristics in oocyte donors and infertility patients
Oocyte donors
Infertile patients
(n = 62)
(n = 46)
(n = 10)
(n = 6)
(n = 536)
(n = 373)
(n = 81)
(n = 82)
24.1 ± 3.71
24.2 ± 4.0
23.8 ± 2.2
23.7 ± 4.2
37.5 ± 5.21
37.8 ± 5.0
37.8 ± 5.3
36.1 ± 6.1
21.0 ± 2.82
20.6 ± 2.6
22.3 ± 2.8
21.5 ± 4.1
24.5 ± 5.12
24.5 ± 5.3
26.8 ± 5.1
22.2 ± 3.1
51.5 ± 26.1
52.5 ± 27.7
49.0 ± 19.4
46.2 ± 21.6
55.0 ± 37.8
57.0 ± 40.2
51.9 ± 34.5
48.8 ± 27.5
6.8 ± 2.93
6.7 ± 3.0
6.6 ± 1.5
8.2 ± 2.8
12.3 ±10.13
12.5 ± 10.2
13.8 ± 13.4
10.2 ± 4.1
4.5 ± 2.94
4.3 ± 3.0
5.7 ± 1.9
4.6 ± 3.7
1.7 ± 2.24
1.6 ± 1.95
2.0 ± 2.9
2.3 ± 2.45
Oocyte yield
17.7 ± 7.76
16.7 ± 6.67
23.7 ± 10.47,8
14.8 ± 6.48
8.1 ± 6.76
8.1 ± 6.8
7.9 ± 7.3
8.1 ± 5.9
FMR1 n (%)
33 (53.2)
26 (56.5)
4 (40.0)
3 (50.9)
315 (58.8)
218 (58.4)
41 (50.6)
56 (68.3)
6 (9.7)
3 (6.5)
1 (10.0)
2 (33.3)
86 (16.0)
51 (13.7)
18 (22.2)
17 (20.7)
19 (30.6)
14 (30.4)
5 (50.0)
0 (0.0)
107 (20.0)
83 (22.3)9
19 (23.5)9
5 (6.1)9
4 (6.5)
3 (6.5)
0 (0.0)
28 (5.2)
21 (5.6)
3 (3.7)
4 (4.9)
Primary infertility diagnosis n (%)
279 (52.1)
199 (47.5)
38 (47.5)
42 (51.2)
Male factor
134 (25.0)
96 (25.7)
18 (22.5)
20 (24.4)
Tubal Disease
105 (19.6)
70 (16.7)
23 (25.3)
12 (13.6)
27 (5.0)
21 (5.6)
1 (1.3)
5 (6.1)
Uterine factors
36 (6.7)
20 (5.3)
1 (1.2)
15 (18.8)
39 (7.3)
27 (7.2)
6 (7.5)
6 (7.3)
Once patients are diagnosed with DOR, they are pre-supplemented with micronized dehydroepiandrosterone (DHEA, 25 mg TID per os) for at least six weeks, prior to IVF cycle start. Ovarian stimulation involves a microdose agonist protocol and stimulation with 450–600 IU of gonadotropins daily, all given as an FSH product except for 150 IU, which is given as hMG [14].
Ovarian FMR1 genotypes and sub-genotypes were determined by Southern blot hybridization and polymerase chain reaction (PCR), as previously reported [3, 7, 8]. In brief, based on a normal range of CGGn=26–34, patient were determined to have a normal (norm) genotype if both alleles were in normal range, as heterozygous (het) if one was outside normal range and as homozygous (hom) if both were outside normal range. Het and hom genotypes, depending on whether counts were above (high) or below (low) normal range, were then further sub-divided.
Statistical analysis was performed using SPSS version 18.0 (SPSS Inc., Chicago, IL). Chi-Square tests were used to compare proportions. Continuous variables were presented as mean and S.D., and were tested by student's t-tests as well as analysis of variance. Post-hoc assessments were performed using the Holm-Sidak method. A P-value of < 0.05 was considered statistically significant.
This study underwent expedited IRB review since it only involved analysis of anonymized data from the center's electronic research database. All of the center's patients sign at initial visit an informed consent, which allows for use of medical record data for research purposes, as long as the patient's anonymity and the medical record's confidentiality are maintained. Both conditions were met here. Like the center's clinical staff, the center's research staff is in writing committed to confidentiality under federal HIPAA rules.
Table 1 summarizes patient characteristics for both patient populations studied. As the table demonstrates, oocytes donors were overall younger (P ≤ 0.001), had lower BMI (P ≤ 0.001), demonstrated lower FSH values (P ≤ 0.001), higher AMH levels (P ≤ 0.001) and higher oocyte yields (P ≤ 0.001). Total estradiol values did not differ between the two groups.
As Table 1 also demonstrates, donors as well as patients in each group, based on race, did not differ in age, BMI, estradiol and FSH. Based on race, donors also did not differ in AMH, though amongst infertility patients Asians demonstrated significantly higher AMH than Caucasians (P = 0.007). African donor demonstrated the highest AMH values; but they did not differ significantly from the other two races. In contrast, patients did not differ based on race, in oocyte yields, while donors did demonstrate significant differences between races, with African donors producing significantly more oocytes than Caucasian (P = 0.007) and Asians donors (P = 0.022).
FSH did not differ either amongst donors or patients based on race. In Caucasian women mean FSH increased from 6.7 ± 3.0 mIU in young oocyte donors to 12.5 ± 10.2 mIU in infertility patients, representing an increase in mean level of 86.6 percent. African women increased from 6.6 ± 1.5 to 13.8 ± 13.4 mIU/mL, a 109.1 percent increase, while Asian women only increased from 8.2 ± 2.8 to 10.3 ± 4.2 mIU/mL, only a 25.6 percent increase.
AMH did significantly differ between Caucasian and Asian patients, with Asian women demonstrating higher levels (P = 0.007). AMH declined in Caucasians from 4.3 ± 3.0 ng/mL in donors to 1.6 ± 1.9 ng/mL in infertility patients, a 62.8 percent decline in mean, in Africans from 5.7 ± 1.9 ng/mL in donors to 2.0 ± 2.9 ng/mL in patients, a 64.9 percent decline and in Asians from 4.6 ± 3.8 ng/mL to only 2.3 ± 2.4 ng/mL, an only 50.0 percent decline in mean.
Finally, the most obvious race-based differences were seen in oocyte donors in regards to oocyte yields. African donors produced by far the largest oocyte numbers, significantly more than Caucasian (P = 0.008) and Asian donors (P = 0.022). Oocyte yields in Caucasians went from 16.7 ± 6.6 in donors to 8.1 ± 6.8 in infertility patients, a 51.5 percent decrease in mean, in Africans from 23.7 ± 10.4 to 7.9 ± 7.3, a 66.7 percent decline, and in Asians from 14.8 ± 6.4 to 8.1 ± 5.9, a 45.3 decline.
he percentage of FMR1 genotypes and sub-genotypes differed significantly between races. Specifically, fewer Asian patients demonstrated the het-norm/low FMR1 sub-genotypes than either Caucasian or African women (P = 0.012).
Different races are characterized by significant variances in reproductive performance. [4, 5]. In association with IVF, women of African descent have been reported to have poorer IVF outcomes than Caucasians [15, 16, 17], though at least one study casts doubt on such a conclusion [6]. Similarly, Asian (usually Chinese) [17, 18] and Hispanic [18, 19] patients were also reported to demonstrate poorer IVF outcomes in comparison to Caucasian women.
We in this study excluded Hispanic patients if they were difficult to classify by race/ethnicity. Our center has been attempting to elucidate causes for observed outcome discrepancies between races/ethnicities for some time. When we noted that Asian/Chinese oocyte donors demonstrate lower mean FOR than their Caucasian and African counterparts, we, as we now know incorrectly, concluded that they suffered from a higher prevalence of premature ovarian aging [20]. We, however, since learned that Asian/Chinese women, simply, age ovaries differently than Caucasian and African women.
This became apparent when we investigated CGGn[21] and later ovarian FMR1 genotypes and sub-genotypes in different races [3]. As it turned out, Chinese/Asian women demonstrated a distinctively different distribution of CGGn, also reflected in a distinctively different distribution of FMR1 genotypes and sub-genotypes.
Specifically, Asian women demonstrated a much higher preponderance of high CGG counts (> 34) than Caucasian and African women, which, once ovarian FMR1 genotypes and sub-genotypes had been defined, translated into a preponderance of the het-norm/high sub-genotype of the FMR1 gene, associated with relative low FOR at young age, but disproportional preservation of FOR into older ages [22]. Such women, therefore, at younger ages, indeed, can be expected to have relatively lower pregnancy chances but will have a relatively more favorable outlook in comparison to other races at more advanced ages [22].
The opposing contrast to Chinese/Asian women is African females, who demonstrate a preponderance of low CGG counts on FMR1, and, therefore, a preponderance of the het-norm/low sub-genotype. Not surprisingly, Caucasians present with the most inhomogeneous distribution of ovarian FMR1 genotypes and sub-genotypes [21, 22].
Since ovarian FMR1 genotypes and sub-genotypes are associated with specific ovarian aging patterns (i.e., declines in FOR) [7, 8, 22], differences in their respective distribution between races are associated with distinct ovarian aging patterns and, not surprisingly, also with distinct pregnancy outcomes in association with IVF [3, 8, 22].
We, therefore, concluded that the cross-sectional investigation of FOR in young egg donors and in older infertility patients of different races/ethnicities should offer another experimental model to investigate the association of ovarian FMR1 genotypes and sub-genotypes in their potential impact on race differences in ovarian aging patterns. That genetic differences on ovarian aging exist has been suggested [1, 2].
Our center serves a racially diverse group of infertility patients, with considerable minority representation of African and Asian patients, the latter mostly of Chinese ethnicity. For that reason the center's egg donor pool has to represent a similar racial/ethnic background, and, indeed, does. Caucasian patients and donors, however, still dominate (Table 1). Especially in the smaller oocyte donor group, small numbers amongst minorities may, therefore, be responsible that only rather few differences were observed between races. At the same time, observed statistical differences, obviously, have to be viewed with caution until others confirm here presented data.
As Figure 1 probably best demonstrates, ovarian aging patterns differ significantly amongst all three here investigated races. They differ in all investigated parameters of FOR, FSH, AMH and oocyte yields (all P = 0.001). Differences between races, however, vary.
One conclusion, again reconfirmed in full agreement with earlier studies [3, 21], the genetically most homogenous women are of Asian/Chinese descent. They start reproductive life with highest FSH levels and lowest oocyte yields in comparison to Caucasians and especially African women, as here demonstrated in young oocyte donors, and demonstrate the mildest increase in FSH and drop in AMH as well as oocyte yields with advancing age, as demonstrated in the infertile patient population.
As noted earlier, they, therefore, can be expected to have somewhat lower pregnancy chances at younger ages, possibly responsible for reports of lower IVF pregnancy rates in Asian/Chinese women [17, 18]. They, however, should have an advantage over other races at older ages, where they still demonstrate higher FOR [22].
Their polar opposite are African women who start with lowest FSH, highest AMH and by far the highest oocyte yields amongst races; yet, as they age, they demonstrate the poorest FOR of all races, based on highest FSH and the largest declines in AMH and oocyte yields (Figure 1).
This picture, of course fits perfectly with the previously noted preponderance of the ovarian het-norm/high sub-genotype in Asian/Chinese and het-norm/low in African women [3, 21]. The data also perfectly correlate with the significantly lower prevalence of the het-norm/low sub-genotype in Asian women (Table 1), though small donor numbers amongst minorities in this study do not allow for robust conclusions on this point.
The het-norm/low FMR1 sub-genotype, here again demonstrated to be very prominently present amongst African women (50.0% amongst donors and 23.5% amongst patients), has been associated with a polycystic ovary-like ovarian phenotype, at young age associated with excessive follicle recruitment and, therefore, rapid depletion in FOR, leading to DOR at relatively young ages [8].
This is, indeed, exactly the ovarian aging pattern here primarily observed in women of African descent. This aging pattern, of course, very well explains widely reported poorer IVF pregnancy outcomes for women of African descent [15, 16, 17].
This study also adds support to recent reports in the literature questioning the sensitivity and specificity of AMH in defining FOR [9, 11]. This is best demonstrated by the fact that, though African donors, by far, produced the highest oocyte yields, their AMH did not differ from other races. Similarly, Asian patients demonstrated significantly higher AMH than Caucasians; yet, oocyte yields were the same.
Here presented data, therefore, reemphasize the evolving importance of the newly described ovarian genotypes and sub-genotypes of the FMR1 gene in their association with typical phenotypical ovarian aging patterns. It, therefore, also does not surprise that they are statistically predictive of pregnancy chances with IVF [3, 8].
The data also suggest that widely reported differences in IVF pregnancy chances between races, at least to a degree, are, likely, determined by FMR1 genotypes and sub-genotypes. It, therefore, would appear important to integrate FMR1 genotypes and sub-genotypes as co-variates in reproductive outcome studies. Indeed, FMR1 genotyping can also be expected to increasingly enter clinical practice.
This study was supported by the Foundation for Reproductive Medicine, and intramural grants from the Center for Human Reproduction.
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There is growing interest in RNA-based biomarkers, and measuring RNA expression holds great promise for stratifying patients based on drug response, drug efficacy, and risk of side effects. RNAscope in situ hybridization enables molecular detection in a morphological context. It provides the cellular resolution required to evaluate tissue heterogeneity and to potentially better screen and select patients.
RNAscope holds great promise for increasing the clinical success of certain drugs by serving as a companion diagnostic (CDx). ACD has therefore created a CDx Assay Development Program that streamlines the assay development process, and provides a detailed Standard Operating Protocol (SOP) that can be transferred to a certified CLIA labs.
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Luciano Pavarotti, who was scheduled to sing last night in a performance of ''Tosca'' at the Metropolitan Opera, canceled because he has the flu. It was the second-to-last ''Tosca'' performance of the season. Mr. Pavarotti, 66, is expected to sing on Saturday night to end the Met season, and possibly his career in the house. The performance will be relayed to a large screen on the Lincoln Center Plaza, with free tickets available to the public. The tenor Francisco Casanova sang the role of the painter Mario Cavaradossi last night, opposite Maria Guleghina in the title role.
Tina Kelley (NYT)Continue reading the main story


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St. Sepulchre's and its neighbourhood
Old and New London: Volume 2
of that year, "his body was brought unto St. Pulcher's to be buryed, ... St. Sepulchre's and its neighbourhood CHAPTER LV. ST. SEPULCHRE'S AND ITS NEIGHBOURHOOD. The Early History...View result
Hundred of South Greenhoe: Great-Cressingham
An Essay Towards A Topographical History of the County of Norfolk: Volume 6
the chapel of St. Nicholas at Lynn, to the west, a messuage near Surflet ... at 2 d. per goose; also 32 quarters of oats, payable at St. Michael, at 15 ... and Hopton; and on Friday the Vigil of the Nativity of...View result
Entry Book: January 1676, 16-31
Calendar of Treasury Books, Volume 5, 1676-1679
of the parish of St. Katherine Creechurch, in the ward of Aldgate, London, merchant, and Christopher Watkins of St. Pulcher [Sepulchre] in the ward ... viz. said Heber, William Tyndall of the...View result
Middlesex Sessions Rolls: 1683
Middlesex County Records: Volume 4, 1667-88
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Index: L - Z
The Diary of Henry Machyn, Citizen and Merchant-Taylor of London, 1550-1563
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Index of places
A Survey of London. Reprinted From the Text of 1603
109, 2913; ii. 176. Aldermary, see St. Mary. Aldersgate, i. 9, 10, 278, ... Bishops Hall, Stepney, ii. 132. Bishop's Palace, at St. Paul's, i. 67; ii. ... 103. Bosworth, i. 115. Bow Church, see St....View result
The city of Norwich, chapter 27: Of the city in Queen Elizabeth's time
An Essay Towards A Topographical History of the County of Norfolk: Volume 3, the History of the City and County of Norwich, Part I
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Chapter 1. The Nature of Chemistry. Robert Boyle 1627-1691. Originally defined the concept of chemical "element.". Geber (Abu Musa Jabir ibn Hayyan, جابر ابن حیان ) 721-815. "Father of Arabic chemistry.". The Study of Chemistry. The Atomic and Molecular Perspective of Chemistry.
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Chapter 1
The Nature of Chemistry
Robert Boyle 1627-1691.
Originally defined the concept
of chemical "element."
Geber (Abu Musa Jabir
ibn Hayyan, جابر ابن حیان) 721-815.
"Father of Arabic chemistry."
The Study of Chemistry
The Atomic and Molecular Perspective of Chemistry
• Matter is the physical material of the universe.
• Matter is made up of relatively few (ca. 100) elements.
• Elements are the buildingblocks of matter.
• On the nano (ultramicroscopic) level, matter consists of
atoms. An atom is a "nano-basketball" -- nano = 10 -9.
• Atoms usually are found in the combined state,
commonly molecules.
• Molecules may consist of the same type of atoms
or different types of atoms.
Not all compounds are made up of molecules.
Many compounds, for example, are composed of ionic lattices.
For this chapter, however, we will confine discussions of compounds to the concept of molecules, which are the combinations of
nonmetallic elements.
The Study of Chemistry
The Molecular Perspective of Chemistry
Classification of Matter
PureSubstances and Mixtures
A pure substance cannot be separated into simpler substances by physical means.
A pure substance has definite and constant chemical and physical properties (i.e., ignition temp., melting point, magnetic susceptibility, spectral patterns)
A pure element is a pure substance that consists only of one kind of atom.
Examples of elements: U, P4, Cl2, C60
A pure compound is a pure substance that consists of more than one kind of atom.
Examples of compounds: HCl, K2SO4 , C2H6O.
Molecules are chemical combinations of two or more atoms which can all be the same,
e.g., Br2 , H2 , S8 , O3 (these are elements)
or different,
e.g., H2O, C2H5Br (these are compounds)
(Elements which have a different number of atoms in their molecule are called allotropes.
Allotropes have different physical and chemical properties, e.g., O2 and O3)
Individual elements or compounds are all pure substances.
For example, individual samples of C, Fe, O2, N2, H2O NaCl, K2SO4 are all pure substances.
The composition of a pure substance is constant.
(e.g., water is always 88.9% oxygen and 11.1% hydrogen)
If different samples are mixed together, this is called a mixture. Mixtures do not have constant compositions.
Classification of Matter
Examples of mixtures:
• air (which contains variable amounts of oxygen, nitrogen, carbon dioxide, water vapor, pollutants, etc.
• milk (which contains variable amounts of galactose, minerals, fats, proteins, etc.)
• carbonated drinks (which contain variable amounts of carbon dioxide, sugars, flavorings, etc.)
• "tap" water (which contains dissolved minerals)
pure substances
Classification of Matter
Pure Substances and Mixtures
Classification of Matter
Pure Substances and Mixtures
If matter is not uniform throughout, then it
is a heterogeneous mixture.
If a pure substance can be decomposed (chemically)
into something simpler, then the substance is a compound.
If matter is uniform throughout, it is homogeneous.
If homogeneous matter can be separated by
physical means, then the matter is a mixture.
If homogeneous matter cannot be separated by
physical means, then the matter is a pure substance.
Classification of Matter
Classification of Matter
The next five elements are:
Na 2%, K 2%, Mg 2%,
H 1%, Ti 0.5%.
The next six elements are:
N 3%, Ca 1.5%, P 1%,
K,S,Na 0.75%
Elements in the Human Body –
including trace elements
Classification of Matter
Use your Periodic Table to refer to all elements and their chemical symbols.
Bring your Periodic Table
to each class!
The Periodic Table
Bring your Periodic Table
to each class!
Classification of Matter
Properties of Matter
Physical and Chemical Changes
When a substance undergoes a physical change, its physical appearance changes, but its chemical nature does not.
When a substance changes its composition, it
undergoes a chemical change
Units of Measurement
SI Units
Units of Measurement
Powers of ten are used for convenience with smaller or larger units in the SI system.
What is a GigaByte?
Units of Measurement - Temperature
Units of Measurement - Temperature
Units of Measurement - Temperature
Units of Measurement - Volume
The units for volume are
given by length3
SI unit for volume is 1 m3.
1 mL = 1 cm3
= 1000 mL
Units of Measurement - Density
Uncertainty in Measurement
Precision and Accuracy (actually discussed in Chapter 2)
Uncertainty in Measurement
Precision and Accuracy
Example: Weigh yourself on your bathroom scales.
Your scales are cheap, and the graduations are every 5 pounds. The precision is bad.
Your scales are expensive, and the graduations are every 0.1 pound. The precision is good.
You know your correct weight from a high-quality scale at the doctor's office, to within 0.1 pound. You weigh yourself on your bathroom scales and find the reading is off by 10 pounds. The accuracy is bad.
Same situation as above, and find the reading is within 0.1 pound. The accuracy is good.
Dimensional Analysis
Method of calculation utilizing a knowledge of units.
Example: 1 m or 100 cm are equivalent
100 cm 1 m
Example: 1 L or 1000 mL are equivalent.
1000 mL 1 L
Dimensional Analysis
Example: Convert 5.6 km to m:
x 1000 m
5.6 km
= 5600 m
Volume conversion. Convert 1 cubic meter to mL.
1 m3 x (100 cm)3 x 1 mL = 1 x 106 mL
(1 m)3 1 cm3


text:
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Integrated conveniently in a massive shopping centre. Our check in was effortless and our room was spectacular. Probably the most luxuriously appointed room we have stayed in to date. No complaints at all. Quiet room, comfortable bed, great location. A special thanks to Rex at the desk who was able ...
I always stay in this hotel whenever I visit Hong Kong. Is very near the Causeway Bay MTR Station. And have many little shops and small eateries. Is just opposite Times Square and walking distance to Sogo departmental stores. Hotel staffs are kind and polite.
Free luggage storage after check-out,the in-room cleanliness are great,room with good wi-fi signal and air-condition,private shower and TV.Toothbrush are also given by them.Location are accessible.
Bed was a bit too hard for my liking but other than that it was very good value for money compared with other hotels in the area.
We stayed in the double room with a private bathroom. The room itself was very small but if you are under a budget and location is your priority this can be your hotel. There are no front desk we saw only the maid in the morning and all communications were on we chat which was very prompt. The hotel ...
Very good. Always stay here when I come to Hong Kong. Value for money.
We (Dad, Mom and 2 kids ages 10 and 8 stayed at the Holiday Inn Golden Mile for four nights (Wednesday though Sunday) for a spring break trip. The positives about the hotel are location, room comfort and staff. The hotel is right next to one of the MTR Tsim Sha Tsui exits which makes getting to the ...
Nice hotel with good price, very convenient and friendly staff.
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Toronto Maple Leafs left wing James van Riemsdyk, right, tangles with Boston Bruins goaltender Tuukka Rask in the first period of Game 1 of their NHL Eastern Conference quarterfinals hockey playoff series in this 2013 file photo. (Reuters)
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Kuster, Shaheen push partisan bill to boost public participation at FERC with subsidy
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The Evening Standard's moist spies have been whittling their way through another long list of possible contenders for the 2002 Pub and Bar of the Year competition.
Here are the candidates. Andrew Jefford samples the pubs, while Edward Sullivan surveys the bars. The finalists will be announced on 8 February
PubsAtlas , 16 Seagrave Road, SW6 (020 7385 9129)
The restrained fidelity with which this old, wood-panelled Truman's interior has been scrubbed and wiped clean but left uncorrupted is one reason to visit the Atlas. Mostly, though, the youthful locals and savvy Earl's Court attendees are here to mop up the well-kept cask ales, a genuinely thoughtful wine list, warm bread and a range of dishes altogether more gastro than grub.
Barley Mow , 44 Narrow Street, E14 (020 7265 8931)
This is one of the least wellknown of London's various Barley Mows; one look at its situation, though, and you're no more likely to forget it than were any of the dockmasters who lived here. There are few prospects which bring greater ease to the soul than the languid Thames viewed from this turn, a pint of Bass, Burton Ale or Greene King IPA to hand - even in winter, when the wide river terrace sends all but the hardiest inside.
The Bedford , 77 Bedford Hill, SW12 (020 8673 1756)
The Moby Dick of Balham, ironically now owned by an outfit called Pocket Pubs, goes from strength to strength. Not so much a pub as a singlevenue community centre and entertainment complex, this big, rangy hostelry can be pleasingly scruffy, open-fire cosy and glam-dram by turn. Live funk, blues, rock, jazz and plain piano, comedy and cabaret, DJs, footie - and a quiet pint if you want that, too. It's hard to be more inclusive than The Bedford. (And the view of Sainsbury's is to die for.)
The Lamb , 94 Lamb's Conduit Street, WC1 (020 7405 0713)
The gentle Lamb continues to charm. No lap-dancing here: the pin-ups on the wall feature the likes of Miss Lettice Fairfax, Miss Ritchie and Miss McCarthy - music-hall stars who have long since warbled their last. The large, horseshoe-shaped bar, equipped with nowmysterious snob screens (originally to occlude the gaze of those in the public bar from their lounge superiors), is a masterpiece of pub feng shui. Service, ales, wines and ham off the bone in this Youngs house are all impeccable.
The Market Porter , 9 Stoney Street, SE1 (020 7407 2495)
When does the cleaner get in? The Market Porter has at least four different clienteles: working men from Borough Market who need its early licence; local office folk sliding in for twice-daily congeniality; foodies on pilgrimage for the Friday and Saturday Farmers' Market next door; and Real Ale tickers keen to put the claim of "120 a week" to the test. None, I'm happy to say, dominates: this remains a much-loved and much-used local which just happens to try harder than most.
The Nag's Head , 53 Kinnerton Street, SW1 (020 7235 1135)
Is your pub ideal founded on the epiphanic memory of a quiet local deep in the Dorset or Northumberland countryside where you drank your first pint some 30 years ago? Do you doubt that you will ever see its like in London? Is the idea that you might find a simulacrum in the most exquisite street in Knightsbridge, within shrieking distance of Harvey Nicks and Vong, plain ludicrous? If so, bend your steps to The Nag's Head. It exists. Here you will find peace and perfection - and the best Adnams west of Southwold.
The Northgate , 113 Southgate Road, N1 (020 7359 7392)
Where Northchurch Road meets Southgate Road stands the Northgate, much changed since its days as the Dog and Dumplings. Jacky Kitching and Christopher Leech, both of them ex-Belgo workers, have returned to their roots with this peaceable, civilised and refined gastro-pub (open evenings only during the week). Coniston Bluebird, Adnams and London Pride, plus a well-considered wine list, lubricate chef Robert Greenway's dishes, fine enough to have caught the eye of Michelin inspectors.
Ye Olde Cheshire Cheese , Wine Office Court, 145 Fleet Street, EC4 (020 7353 6170)
We searched and we struggled and we ransacked: no, no one could remember the Cheshire Cheese ever featuring as a previous Pub of the Year contender. Perhaps familiarity bred contempt back in Fleet Street days. Whatever the truth, it has been gross neglect. If one building in our city is capable of expressing four centuries of eating, drinking, talking, arguing, smoking and roistering in its time-cured timbers, it is this seven-bar wonder, more Swiss cheese than Cheshire. Pity the poor plumber; alas for the electrician. For drinkers, though, this mansion of many rooms, now owned by Sam Smiths, is a delight.
Portobello Gold, 95 Portobello Road, W11 (020 7460 4900)
A Pub of the Year, it goes without saying, should be singular, and Portobello Gold is certainly that. During the day, it's a sort of internet pub, with terminals in the bar. The restaurant at the back is blue lagoonish, semi-tropical; oysters a speciality. Chess and backgammon players are welcome; there are papers for the solitary, and pork scratchings for them as likes 'em. The multi-faceted wine list is partnered by a cigar list; the beers, meanwhile, work hard in the cause of Anglo-Belgian friendship. (It's been 17 years since Michael Bell chucked out the Hell's Angels by alienating them with courtesy and fresh flowers - doesn't time fly?)
The Royal Oak, 44 Tabard Street, SE1 (020 7357 7173)
Neat, tidy, freshly painted, with lacy net curtains and beautifully engraved glass, with political biographies in place of raucous music and flashing fruit machines, this is Harvey's only London pub - and it's one of exquisite classicism. A full range of Harveys' beers on tap and impeccably served provides, of course, the backbone of pleasure here.
BarsAkbar, 77 Dean Street, W1 (020 7437 2115)
It's cocktails all the way at Amin Ali's oh-so-smart Indian-style bar in the basement of the Red Fort restaurant. All furnishings and fittings were sourced from the subcontinent to bring a flavour of Indian chic to the heart of the West End. The eclectic cocktail list has been cleverly collated by Douglas Ankrah from the Lab bar in nearby Old Compton Street and represents very good value for money.
Babushka House , 648 King's Road, SW6 (020 7736 4501)
Nick House, bon viveur and one of London's more empirical club promoters, has transcended his role as social butterfly and now has a house he can call home. In this joint collaboration with Babushka vodka bars, DJs spin funk, disco and party music in an environment that is, well, just a tad on the kitsch side, with dÈcor reflecting a throwback to a Seventies suburban home.
Baltic , 74 Blackfriars Road, SE1 (020 7928 1111)
Blackfriars Road seems to have come out from the cultural wilderness since the arrival of Southwark Tube station. And fast on the rails behind this significant arrival came Baltic, the creation of Jan Woroniecki, whose sistervenue, Wodka, has been lifting the spirits of Kensington folk for as long as they can remember. Baltic is a dramatically modern bar and restaurant dedicated to the finest gastronomic and libational delights of the Balkan States.
Corney & Barrow , Broadgate Circle, EC4 (020-7628 1251)
It was as recently as last month that the builders' hoardings came down to reveal a splendidly modern glass structure stretching the entire length of the upper level of Broadgate Circle. Smart and efficient staff offer a quality wine list with a choice of more than 50 available by the glass. A top spot to unwind at the end of the day and watch the shenanigans on the ice rink below.
Eclipse , Walton Street, SW3 (020 7581 0123)
Eclipse doubled its size last summer by bashing through into a neighbouring unit. The new room, with its own small bar, contains louche, clandestine-looking booths and has the distinct air of an upmarket Moroccan souk bar. Bartenders of some pedigree prepare quality cocktails, and there's a small but decent enough wine offering and a sophisticated champagne list for the braying Sloanes.
Hakkasan , Hanway Place, W1 (020 7907 1888)
Hakkasan, a former underground car park on scary Hanway Place, is today a ravishing, subterranean den of opulence and style that is so drop-dead-gorgeous it would make a supermodel weep. It is brought to us by Alan Yau, the founding father of Wagamama. Cocktails are the order of the day here - not cheap, but boy do you get what you pay for.
Lowlander , 36 Drury Lane, WC2 (020 7379 7446)
This new bar in the far-flung reaches of Covent Garden brings together the very best of food and drink offerings from the Low Countries of Belgium and the Netherlands. There's a sparkling parade of 15 beer fonts currently dispensing 13 styles of draught beers, with a further 30 in bottles behind the bar. Food ranges from excellent snacks to a full-blown a la carte menu.
Nylon, 1 Addle Street, EC2 (020 7600 7771)
Ten years ago you'd have been hard pushed to get a drink after 9pm from any hostelry in the City. Today, at Nylon, the fun now lasts until 2am on Friday nights. A sober enough restaurant by day, many of the tables are removed in the evening to make way for the madding crowds who come here for the cheesy retrostyle glam with Seventies music.
Positively 4th Street , 119 Hampstead Road, NW1 (020 7388 5380)
The curious name of this bar comes from the title of a Bob Dylan song that he penned back in the Sixties. This is an Art Deco-style bar that you'd expect to find in downtown Manhattan, but it has adopted many Oriental influences both in design and in the food-anddrinkoffering. This is a relaxed, deliberately unpretentious bar where you can kick back and relax to the music of Dylan and Gershwin.
The Rockwell Bar, Trafalgar Hotel, Spring Gardens, SW1 (020 7870 2900)
Minimalism is the new chic, of course, and The Rockwell bar that is the lobby of the Trafalgar Hotel is a classic example of the modern genre. The bar focuses almost entirely on the wonderfully encapsulating world of bourbon with around 100 different styles on offer. Food on the menu includes delicious bite-size snacks of fish and chips, burgers and sandwiches.
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Game preview
Here's a preview of tonight's game at 7 between Chicago and Milwaukee.
Against Milwaukee: 1-3-0-1
Standings: 2nd in Midwest, seven points behind Grand Rapids.
Streak: W 1
Road rank: 24th (8-9-2-0)
Special teams: PP 23rd (15.5%) PK 25th (80.4%)
Points leader: Brett Sterling 28 Pts in 32 Gms (15 G 13 A)
Also keep an eye on: Darren Haydar. He had just six points, all assists, in his first 16 games this season. In his last 18, he's got nine goals and 12 assists for 21 points.
Other notes: Chicago's second-place lead over Milwaukee is just one point, but the Wolves have played three fewer games. … Chicago has only one victory in five games against the Admirals this season. The Wolves have lost the last three by one goal, and they are 0-3 in Milwaukee thanks to 14 goals allowed. … Anton Rodin has six assists in the five games. Sterling has three goals and two assists in four games. Goalie Matt Climie is 0-3 with a 3.78 GAA. … Chicago is 6-2 in its last eight games.
Against Chicago: 4-1
Standings: 3rd in Midwest, one point ahead of Peoria and two ahead of Rockford.
Streak: W 2
Home rank: 16th (11-4-2-2)
Special teams: PP 29th (10.8%) PK 19th (81.8%)
Points leader: Taylor Beck 31 Pts in 36 Gms (7 G 24 A)
Also keep an eye on: Austin Watson. He has four goals and three assists in five games against Chicago.
Other notes: Daniel Bang and Cam Reid will play tonight. Bang missed the last 15 games and Reid the last eight because of injuries. … Milwaukee begins its post-all-star portion of its schedule holding the 11th spot in the Western Conference playoff chase. Last season, the Admirals were one of four teams which were not in a playoff spot at the break but still qualified for the postseason – its 10th in a row. The team has won two straight after a six-game winless streak. … Jeremy Smith led all goalies last week with 107 saves in three games. That was 20 more than anyone else. … Jani Lajunen has an assist in each of his last two games after going the previous 11 games without a point. … This is the Admirals' only game in a 12-day stretch. They're off until Friday when Houston visits. … Chris Mueller has three goals and three assists in the five-game series, and Patrick Cehlin has one goal and five assists. Taylor Beck, despite facing Chicago just two times, has two goals and three assists. … The UW band will be in attendance.
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- Admirals set date for first home game
- Admirals season comes to end
- Admirals try to save season tonight
- Griffins 2, Admirals 1: Milwaukee may have played final game at the Bradley Center
- Notebook: Game 2 tonight; Milwaukee trails 1-0
- Griffins 3, Admirals 1: Milwaukee drops Game 1 of playoffs
- Griffins at Admirals: Game 1 of playoffs tonight
- Admirals end season much better than last year
- Admirals' first-round opponent is Grand Rapids
- Condors 5, Admirals 2: Bakersfield crashes the party


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The Deputy Prime Minister, Nick Clegg, has rejected calls to routinely arm police following the death of two female police officers in Manchester.
Speaking at a central London youth club today, Mr Clegg, warned against providing weapons to all officers, claiming there would be "considerable risks" in a move to do so.
Greater Manchester Police officers, Nicola Hughes, 23, and Fiona Bone, 32, died in a gun and grenade attack after they were called to investigate a reported burglary on Tuesday.
Mr Clegg's comments followed calls from Paul Beshenivsky, whose PC wife was shot dead in Bradford during an armed robbery in 2005, to allow officers to carry firearms so they were prepared for any situation they found themselves in.
"I don't think this is the time to rush to instant judgments, this really is a time for mourning and support, of course, for the family and friends of the two women who have been killed," said Mr Clegg.
He added: "I think if we were, in an instant to, in a sense, arm our police to the teeth so they become separate from the public that would be quite a big change which would have considerable risks attached to it."
Providing officers with firearms routinely needed to be looked at "very carefully" and not in an "instant way" after a terrible tragedy, Mr Clegg said.
Sir Hugh Orde, the president of the Association of Chief Police Officers, warned against a potential change. "Guns don't necessarily solve the problem. Many colleagues in America are lost without even drawing their gun at close ranges," Sir Hugh told BBC Radio 4's Today programme.Reuse content


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Mocha Girl Alysia
Founder at Mocha Girls Read
Just another girl who loves to read and then read some more and wants to meet others like me.
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