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25162 Charlinda Drive
Mission Viejo, California, 92691
Commute to Downtown Laguna Hills
Most errands require a car.
About your score
25162 Charlinda Drive has a Walk Score of 47 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
This location is in Mission Viejo. Nearby parks include Aegean Hills Park, Clarington Park and Beckenham Park.
Explore how far you can travel by car, bus, bike and foot from 25162 Charlinda Drive.
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87 Rancho Santa Margarita - Laguna Niguel
0.2 mi
177 Foothill Ranch - Laguna Hills
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91 Laguna Hills - San Clemente
0.7 mi
212 Irvine - San Juan Capistrano Express **
0.7 mi
89 Mission Viejo - Laguna Beach
0.8 mi
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This location is in the city of Mission Viejo, CA. Mission Viejo has an average Walk Score of 36 and has 93,305 residents.Learn More About Mission Viejo


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Lux Plans Expansion, at Long Last
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Home › Forums › Gear Forums › Gear (General) › How do you pack a blow up mattress?
Mar 20, 2012 at 1:01 pm #1287520
Ty TyMember
@tylerdLocale: SE US
I have a Exped Synmat UL7. I have always carried it rolled up in it's little stuff sack and placed into my pack wherever it fit best that way. I am contemplating saving the time/fuss and just putting it in the bottom of my bag, inside my trash compactor bag liner either above or below my quilt which I just stuff in the bottom.
The only con I can think of is might be more susceptible to a puncture from a tent pole, stake, maybe even a stick poking the backpack.
Any thoughts? How do you pack your blow up type mattress?Mar 20, 2012 at 1:07 pm #1856677
Ben 2 WorldBPL Member
@ben2worldLocale: So Cal
I squeeze the air out, close the valve… then fold down flat to approx. the size of my pack and slide it into the pack. Having the couple layers of padding flat against the pack back helps stiffen my UL pack — and is more space efficient than packing in a tight cylinder.Mar 20, 2012 at 1:50 pm #1856694
Nico .BPL Member
@nickbLocale: Los Padres National Forest
Depending upon which pack I'm using on the trip, I either just fold my Neo-Air into thirds width-wise and roll it up (just like how it came out of the box), rubber band it (no stuff sack) and place it wherever I have room in my pack. I make sure to pack it with soft non-sharp stuff, so it usually goes in between my quilt and my puffy jacket.
Or… with a frameless pack, I'll deflate it and often fold it up to fit the back panel area of the pack and slide it in (maybe even add a little air to it to stiffen up the "frame") to serve as part of a virtual framesheet with a cut down GG Nightlight pad.
I've often wondered how a NeoAir or other inflatable pad would handle just being stuffed into my pack, say, with my bivy, but have avoided trying it for fear of springing a leak from a crease or damaging a pontoon or whatever…
Curious to see what others do.Mar 20, 2012 at 2:31 pm #1856719
David GoodyearBPL Member
@dmgoodyLocale: mid-west
First I tried to get it back into the original stuff sack. Not much fun – I may add. Last year I tried something new. Since I had a new pack with different compartments, I left it inside my bivy with my sleeping bag. I rolled it up to expel the air and then stuffed it into a dry bag type compression stuff sack. It worked out great – never got wet and it was easy to setup camp – pull and fling.
In the winter, I use an exped-7 on top of a foam pad. I found that I can fold it into quarters and put it into a flat stuff sack and it fits in my sled sandwiched between my sleeping bag and foam pad cut and folded in thirds.
DaveMar 20, 2012 at 2:32 pm #1856720
Dan JohnsonMember
@seattleLocale: PNW
I fold it in thirds so that it fits my back panel of my frameless pack. I've found this way to be the best for maximizing usable space. Plush a little cushion never hurts :)Mar 20, 2012 at 2:37 pm #1856722
Mary DBPL Member
@hikinggrannyLocale: Gateway to Columbia River Gorge
My pack has an internal pad pocket. Since I bought it in 2005, I have always folded my deflated inflatable and put it in the pad pocket. Never any problems and the pad is protected. No stuff sack needed, either. If your pack has a hydration reservoir pocket in the back, it could be used for the pad.Mar 20, 2012 at 2:44 pm #1856728
brent driggersBPL Member
@cadyakLocale: southwest georgia
I roll mine up in my tyvek ground cloth and strap on the bottom. old timey style. It may sound silly but I like the way that it allows me to sit my pack on the ground and have it not fall over. In winter I roll up my 1/8" ccf AND the tyvek around it.Mar 20, 2012 at 10:09 pm #1856954
Christopher YiSpectator
@traumaheadLocale: Cen Cal
Synmat UL7 folded into a rectangle, slides into the hydration sleeve on my HMG Windrider. Switching back to foam pads, don't know what I'm going to do now.Mar 21, 2012 at 6:58 am #1857049
Ty TyMember
@tylerdLocale: SE US
Seems like a lot of people are folding into thirds and using it as additional back padding, interesting. I guess I will try it that way this weekend and see how it goes, makes a lot of sense.
ThanksMar 21, 2012 at 10:16 am #1857141
Elliott WolinBPL Member
@ewolinLocale: Hampton Roads, Virginia
I like the idea of using that otherwise useless hydration pouch for my new Neoair. I don't like the idea of just using it as back padding because I worry that something might puncture it, although many folks do this and have no problem. But I can be careless at times so maybe my hesitation is justified.Mar 21, 2012 at 10:27 am #1857146
Barry PBPL Member
@barrypLocale: Eastern Idaho (moved from Midwest)
"How do you pack your blow up type mattress?"
I roll my short neoair. I fold it lengthwise in 3rds and then roll. This is the way it came from Thermarest. I tried:
1. rolling after folding in half.
2. folding it in different sections (like folding a sheet).
I abandoned those ideas later when I figured out the original way takes up the least room in my pack. And small packs are easier to backpack with :)
-BarryMar 21, 2012 at 10:28 am #1857147
Larry De La BriandaisBPL Member
@hitechLocale: SF Bay Area
I have also been considering a different way to carry my pad. Putting it back in the stuff sack just seems like a waste of time and space. After reading these great ideas I am going to try and roll it up in the tent. Thanks for the idea!Mar 21, 2012 at 11:09 am #1857156
David ThomasBPL Member
@davidinkenaiLocale: North Woods. Far North.
I multipurpose it as a back padding in a frameless pack. When carrying a framed pack on family trips, I roll it and tie it with a 20" length of very small cord or sometimes a a hefty rubber band. If worried about punctures, wrap it in a sweater, ground cloth, rain shell, etc.Mar 21, 2012 at 12:37 pm #1857196
Steofan MBPL Member
@simauliusLocale: Bohemian Alps
My Neo Air gets folded in thirds lengthwise then rolled up as it came from the company.
It is then dropped into an old knee-high sock. I give the middle of the sock a few twists and roll the top half of the sock back down over the rolled mattress. The sock does weigh in at a huge 26 gm ( as opposed to the 16 gm Thermarest stuff sack ) but I have had zero issues with leaks or holes from either the ground or from items in the backpack.Mar 21, 2012 at 1:06 pm #1857204
Evan McCarthyBPL Member
@evanrussiaLocale: Mid-Atlantic
I've been pretty cavalier about packing my Burn and Exodus without any issue. As long as nothing is poking into my back, it never seems to matter to me. I don't use stuff sacks and do the burrito approach as popularized by Mike Clelland. The Neoair gets roughly folded and jammed down into the trash compactor bag in my pack along with everything else.Mar 21, 2012 at 5:19 pm #1857330
Jim ColtenBPL Member
@jcoltenLocale: MN
I carry my quilt and neoair pad inside an oversized stuff sack that then gets jammed into the bottom of my pack. The neoair pad is flattened, folded in half lengthwise, loosely rolled and the roll is expanded inside the sack til it is snug against the sides of the sack. Quilt is then stuffed inside that.Mar 21, 2012 at 6:17 pm #1857369
Ken T.BPL Member
deflated of course.
sorry. just had to.
You must be logged in to reply to this topic.


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Month: October 2013
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Okay, all cats are pretty amazing — as in they have the capability to amaze. But Burt the cat might be the amazing cat. After all, his Facebook page says so. Burt was found in a box outside Animal Aide, a rescue organization in Ontario, Canada. It wasn't fun times, Maru-style, cat in a box, …
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"Ooooh, it's yourself!" said my Auntie B, standing in the doorway of number 30 Oakdene Parade, looking 35 years younger than her 85, at least. That's what a life of no alcohol or nicotine and utter purity and human kindness will do for you. My darling Auntie Bertha grew up in Belfast and moved as …
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New Braunfels Herald Zeitung (Newspaper) - March 17, 1996, New Braunfels, Texas Check out IRoxolin Kruogor's "Around Town** column on Pas# IB! Good morning!Funding ideas suggested Ie renovate LCBA building. See Opinion, Page 4A NVFD fired up about building repair plans By ROGER CROTEAU City Editor In the aftermath of the fire that did about $10,000 to their firehouse, members of the Northcliffe Volunteer Fire Department are hoping to not just repair the damage, but to double the size of the building. "We're thinking this might be the time to add on to the facility," said Chief David Slatter. "We'd like to add a meeting room, kitchen, a real office and good bathrooms." Slatter said the department does not have any estimates for the cost of the project yet. The firehouse was built in 1982. Last Sunday morning, in the first structure fire the department has responded to in lour years, the building caught fire. Members believe children playing behind the building set a small wooden storage bin the department uses to store aluminum cans on fire. The fire spread to the building itself. A reward is being offered. "It created one of the largest adrenaline rushes I've had so far," Slatter said. "I was on the golf course and everyone said 'Hey, isn't that your firehouse,' and I started running," said department member Christine Dicks. Slatter said when he joined the department five years ago the department was $35,000 in debt. In five years, that debt has been eliminated and both fire trucks were replaced, so it is not unfeasible for the department to expect to be able to pay for an expansion. The department receives $ 13,200 a year from the county and holds some fund-raisers. But the bulk of its money comes from residents of Northcliffe and Scenic Hills, the gated retirement community the department serves. "We ask for $36 a year from each household. In Scenic Hills we get about 90 percent participation, In Northcliffe we get about 20 percent participation," Slatter said. "We think having a nice meeting room would provide an important service to the community," he said. Unicorns advance The NBHS boys soccer team blanks Hays 3-0. See Page 6A Taking aim Senior citizens line up for concealed handgun classes. See Page Bl for more details. Antique Show and Sale Aliene Weaver and Judy Cude inspect an antique ring Saturday during the 46th Semi-Annual Antique Show and Sale at the Civic Center. The event continues today from noon to 5 p.m. Admission it $5. Obituaries.....................................2A Opinion.........................................4A Market Place...........................3-12B Sports Day................................6-7A People..........................................1B Stammtisch birthday wishes from the Herald-Zeitung! The New Braunfels Herald-Zeitung extends birthday wishes to: Jason Oliver (Monday), Cavin Brinkkoeter (18th), Kelly 3rinkkoeter (Monday), Ricky Maldonado (18 anoa), Mario Villarreal, Brianne Michelle Sanchez, Hortencia Carrillo i belated), Herb Eberhard, Alice ' Vllliams, Noel Lovett, Pamela Sue Timmermann (34 years), Lauren Hernandez (2 years) and Amber Strainer. Happy anniversary to Bill and Sandy Kolthoff (Monday), Valeria and Clifford Boehme (8 rears) and Barbara and Edwin 'raise. Lotto Texas Saturday night's 12,14, 35,39 Est $4 million jackpot --TEXAS T LOTTER1/ ADHD support group moots Monday New Braunfels Children and Adults with Attention Deficit Disorder, a support group for persons concerned with ADHD, meets on the 3rd Monday of each month at Oakwood Baptist Church on Loop 337. The next meeting is March 18, 1996 at 7 p.m. All interested persons are invited. Call Karen Owens at 629-2033 for more information. Sowiors can havo input at services hearing The Comal County Senior Citizens Foundation will hold a public hearing to receive oral or written comments by interested persons on the effectiveness and/or the direction of present and future social services which directly impact them The public hearing will be held on Tuesday, March 19, 1996, starting at 11 a rn. at the Comal County Senior Citizen Center, 655 Landa Street, New Braunfels, Texas 78131. Area Agency on Aging staff of the Alamo Area Council of Governments will be available to discuss services for the elderly 30 minutes prior to the hearing and will answer questions before and after the meeting. Rummage sale for Conservation Society next Saturday The New Braunfels Conservation Society will host a Rummage Sale from 9 a m. to 3 p.m. on Saturday, March 23 at 521 W. San Antonio. For more information, call Barney Canion at 625-8766. Cancer support group celebrating one-year anniversary. The Dialogue — Comal County Cancer Support group will celebrate its one-year anniversary March 28. The group meets the fourth Thursday of each month from 6:30 to 8 p.m. at the north building next to Victoria Bank at 1000 Walnut. The group is for cancer survivors, their families and significant others. It is sponsored by the American Cancer Society. i_ New Braunfels 41.0 MO 16 10/22/99 SO-UEST MICR0PUBLISHING 2627 E! YANDELL DR SUNDAY SIAO PASO, TX 79903- Herald-Zeitung 56 pages in four sections ■ Sunday, March 17, 1996 Serving Comal County and the surrounding area ■Home of HERB EBERHARD Deaths ruled double murder/suicide Vol. 144, No. 90 By MELANIE GERIK Staff Writer The sheriff s department Friday ruled the deaths of a Comal County mother, father and son a double murder/suicide, based on preliminary autopsy and investigation results. "There is absolutely no doubt in our minds that Stanley Lindsey shot himself," said Lt. Sumner Bowen. "We couldn't be any more positive." The body of Stanley Lindsey, 43, was found after his truck ran off Smithson Valley Road and crashed into a cluster of trees. Preliminary autopsy reports indicate that he died from a contact gunshot wound to the left side of his head immediately before the accident. Deputies believe that Lindsey shot himself with a 9 mm gun, which has not been recovered. Bowen said Lindsey had talked to friends a few weeks ago about purchasing a 9 mm gun. He added he believes someone may have seen and picked up the gun, but is afraid to turn it in for fear of implication in the crime. The physical search for the gun ended Friday. Bowen said the sheriff s department used manpower, specially-trained dogs and metal detectors to search for the weapon at the scene of the accident, which was about two miles away from the Lindseys' house where the bodies of Pennye, 43, and Sheldon, 18, were found. Sheldon Lindsey was shot and killed in the master bedroom of the white brick house on the comer of Antler Pass and Circle Oak in the sub- There is absolutely no doubt in our mind that Stanley Lindsey shot himself.' — Lt. Sumner Bowen Comal County Sheriff's Office division of Oak Cliff North, about three miles east of Bulverde. Pennye then was shot and killed in the breakfast nook near the kitchen, and may have been trying to call for help, Bowen said. The phone was off the hook, but the sheriff s department has no records of 911 calls from the residence on Tues day night or Wednesday morning. An antique .38-caliber revolver was found under a bridge on Farm Road 311, along with Pennye Lindsey's jewelry box and a silhouette charm engraved with Sheldon's name and date of birth. Both Pennye and Sheldon Lindsey died from .38-caliber gunshot wounds. The sheriff s department did not have any motive for the murders and suicide, and will continue to investigate the incidents to eliminate other possibilities. "We have a lot of loose ends to tie up." said Sheriff Jack Bremer. Bowen said Stanley Lindsey, a welder in a San Antonio car maintenance shop, worked long hours and was under a lot of stress at w ork. Story of student's heroics to air on CBS A 14 year-old New Braunfels Middle School student will be getting national recognition this week for his efforts to help a choking student. Clay Coleman was eating lunch in the school cafeteria in January when a fellow student began to choke. Coleman, who had learned the Heimlich Maneuver in the Boy Scouts, ran around the table to perform the procedure, and saved the boy's life. Ann Leyh, a neighbor of Coleman's, w rote a letter to the "CBS This Morning" Program nominating him for Hero of the Day. In her letter, she said he w as a hero "in every sense of the word." "In these troubled times, what a comfort to know there are teens like Clay around w ho are not afraid to act when someone is in trouble. Thank you, Clay. for your quick-thinking and caring attitude," she wrote. CBS will honor Coleman as Hero of Day on "CBS This Morning." The show w ill air Tuesday, March 19. The show is on weekdays at 7 a m. on Channel 5. In addition to the national recognition on television, Coleman is also being considered for a Life Saving Award from the Boy Scouts of America for his actions. Coleman is the son of Mr. and Mrs. Carroll C. Coleman of New Braunfels. Cedar fever makes comeback in area away. Furthermore, what is still on the trees is being stirred up by the winds. "I think we just need a good rain so what little is left will be wiped away," said Hampel._ 'I think we just need a good rain...' — Dr. Frank Hampel Jr. The extension of the cedar pollen season has been even harder on sufferers because of other allergens rn the air, said Hampel. Other trees are now entering their season. "We don't have much of a break normally because we have so little winter," said Hampel. "This isn't going to give much of one at all." Since this is the first time he has seen the season be prolonged, he said it is hard to say w hen it may end. He also added it "depends on how sensitive you are" because even trace amounts effect some people. However, in the meantime, Hampel said people should just keep using the medications that work best for them, including antihistamines and decongestants. By DENISE DZIUK Staff Writer Those who thought their troubles with Mountain Cedar pollen were over are in for a surprise. Despite the fact that the air should have been cleared of it weeks ago, cedar pollen is still affecting many. Dr. Frank Hampel Jr.'s office provides daily pollen readings for the New Braunfels area and has recorded the presence of cedar pollen w eeks after the season was to end. Hampel said the mountain cedar season typically ends around the second week of February. Despite the fact that it is already mid-March, he said the pollen is still in the air, and it is not just in trace amounts either. "We've had readings of about 700 (parts per cubic meter of air) at times, which is a large amount," he said. Hampel said it is unusual to still have cedar pollen in the air. He said he does not know for sure why it is still measurable, but believes the weather may have something to do with it. Hampel said the trees are not pollinating any longer, but there has not been a substantial rain to wash the pollen ;
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This dog is ace.
Her owner was finishing a cigarette when the bus arrived one day, and she knew they were going to the dog park. So what did she do? Just got on the bus by herself.
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Eclipse – who is a 2 year old Labrador/Bull Mastiff cross – has become a local celebrity in Seattle. She sits next to strangers on the bus, and keeps a keen eye out of the window, looking for her stop.
Her owner, Jeff Young, said:
Probably once a week I get a phone call. 'Hi. I have your dog Eclipse here on 3rd and Bell.' I have to tell them, 'No. She's fine.' She knows what she's doing.


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mwc had een nieuw logo ontwerp nodig en lanceerde daarom een wedstrijd op 99designs.
Een winnaar werd gekozen uit160 ontwerpen ingezonden door32 freelance designers.
We are looking for a looking to launch our new company online. We need a simple "stand alone" logo/symbol with the name (think under armour, nike etc..) Athlete Unltd. needs a logo that could be used online, on cards and the symbol possible on clothing (tags etc).
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BioMed Research International
Volume 2013 (2013), Article ID 182531, 7 pages
Research Article
Ovarian Stimulation Affects the Population of Mouse Uterine NK Cells at Early Pregnancy
1Anatomy Department, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran
2Immunology Department, Tarbiat Modares University, Tehran, Iran
Received 28 August 2013; Accepted 27 October 2013
Academic Editor: Kotaro Kitaya
Copyright © 2013 Parvin Dorfeshan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [2 citations]
The following is the list of published articles that have cited the current article.
- Rachel Weinerman, and Monica Mainigi, "Why we should transfer frozen instead of fresh embryos: the translational rationale," Fertility and Sterility, 2014. View at Publisher · View at Google Scholar
- Mandana Beigi Boroujeni, Nasim Beigi Boroujeni, Mohammad Reza Gholami, Masoud Beigi Boroujeni, Afsaneh Shafiei, and Maysam Rasouli, "Low-Dose Aspirin and Uterine Natural Killer Cells in Mice at Day Seven of Pregnancy," Jentashapir Journal of Health Research, vol. 6, no. 6, 2015. View at Publisher · View at Google Scholar


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Random encounters with WadeMature
Clubbing all night and day.
Wade retracted his hand from the portly woman's grasp, it was tough, hard like a mans. If she wasn't forty years too old, she'd be a decent lay. Her breasts nested themselves deep in black Chantilly lace. Her brunette hair was coarse, but decently done up, more or less professional looking.
If it weren't for the ring of dark hair around her mouth, Wade would of fucked her. It has been six years since he got out. With six years in, a watermelon in a thong looked sexy. It was the hair, it wasn't even peach fuzz, but thick hair. It danced around her face gloriously, like it was best friends with her. Wade couldn't wrap him self around that without wanting to regurgitate his lunch. Even six years of prison life couldn't rectify that nightmare.
"Fuck off," he articulated, in the nicest way imaginable. "I'm not interested."
The woman dismisses the rejection, and prances around with her arms in the air, twirling aimlessly around the street as if to try and seduce Wade with her body. It was relatively sexy, and her ass was in pretty good shape; it had curves and substance. But the hair around her face was inexcusable and made Wade rather derisive towards her.
"Fuck off already you gutter slut. Shave that goddamn possum off your face." The woman scoffed at his taunt and scurried off into the unforgiving night. "Good riddance," he shouted, and turned towards a bar across the street. Wade often found himself in strip clubs and bars, he had an addiction to tits and ass, even more so now that he was a free man. The only thing he didn't have, was his tactical gear.
He knew it was only a matter of time before they came after him. In some way, he was a celebrity. Highly sought and incredibly paid. But those who sought him wanted to kill him and those who paid him were just as bad as those he kills. In the business of assassinating, money is the judge of who's good and bad.
The bouncers outside of the club were going to be a problem. They were heavily armed and armoured extremely well. They also had the Marauder logo stamped on their chest. The Marauder's currently have a bounty of fifty-million dollars for Wade's head. His addiction to tits and ass had to wait for now.


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1955, Methuen
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Very good in good dust jacket. 1955. 162 pages. Cream jacket covering brown cloth boards with gilt lettering. Pages remain bright with light foxing to text block edge and the endpapers. Binding is firm with light tanning to the spine and corner bumping to boards. Unclipped jacket has moderate soiling to the covers and light scuffing to the ends of the stained spine. World of Rare Books Item ref. 1461742313RF (Use this ID when enquiring about this item. )
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Be Forever Mine, You
Friday night's weekly Flamingo Fridays party at PS14 marks the first show in a while on this side of the county line for the Miami foursome Astari Nite. The band has been playing out relatively frequently, but recent weeks have seen it playing mostly around Broward and even West Palm Beach.
And instead of slowing down for the summer, instead frontman Mychael Ghost and company are ramping it up. They've begun work on an EP, and here's how Ghost describes the song's narrative: "[the song is] about a young man who is seduced by a ghost he can't get out of his mind. She haunts him so much it's the cause of his death. He finally meets up with the ghost in the end -- I think she is Wendy Darling."
Well, not sure how the Peter Pan references fit in, but you'll know already if you enjoy this kind of morbidity and romanticism.
Besides playing tonight's show at PS14, Ghost says Astari Nite is also one of the scheduled headliners for Respectable Street Cafe's anniversary party later this summer. He is also throwing "a huge event" at Culture Room mid-summer. Stay tuned to Crossfade for details.
Fri., June 5, 2009
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CC Hair Extensions: First Impressions and IntroductionSeptember 15, 2015
CC Hair Extensions is an online portal which sells various hair extensions with high quality but low price across the world. These are some types of hair extensions available on the website:
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These are the simplest kind of hair extensions. It comes with a clip attached with hair. One needs to simply clip it on hair and woom! Instant long hair!
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6 Day Cairns & Great Barrier Reef Cruise from $1699*
Hotel, Cruise and Transfers
Coral Expeditions is Australia's leading small ship and expedition cruise line, with an unrivalled worldwide reputation for cruising excellence built over almost 30 years. Your visit to the Great Barrier Reef is a once-in-a-lifetime experience and in a short amount of time you can discover the region's natural wonders. Only when you experience the Reef with Coral Expeditions will you awaken each morning at exclusive reef moorings, with the very best coral gardens, rainforests and secluded tropical islands right outside your window.
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- Round trip transfers between airport and hotel
|Travel Dates
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|*Terms & Conditions: Prices are land only, 'from' per person, based on double occupancy and Thursday departures for travel between 1 April 2017 and 31 March 2018; otherwise supplements will apply. Book by 22 March 2018. Airfare is not included unless stated on itinerary. Single supplements, black-out dates and seasonal supplements may apply. Prices are current at time of posting (18 January 2017) and may differ when you book your travel and are not guaranteed until full payment is received and processed. Strictly subject to availability. Not retroactive and not combinable with any other special or vacation package offer. Upgrades are available. All prices, itineraries and routings are subject to change without notice. Please call for our current prices. Hearing impaired persons may dial 711 (National Relay Service) to contact us at the above number. Tour Code: SO17037. CST#2001136-50
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Udforsk beslægtede emner
Cartagena , Colombia tiene mucho que ofrecer, incluyendo un baño de barro en un volcán !
Cartagena is one of the most popular destinations in the Colombian travel circuit #Cartagena
Salt Cathedral Series (First Colombian wonder) | Flickr - Photo Sharing!
Tayrona National Park, Santa Marta, Colombia - South America
Isla Mucurá, Cartagena, Colombia. South America. Bellísimo.
River of Five Colors/ Caño Cristales in Columbia.Caño Cristales is a Colombian river located in the Serrania de la Macarena, province of Meta. aka "The Liquid Rainbow" or even "The Most Beautiful River in the World"
Santuario de las Lajas, Basílica Church, was built in Gothic Revival style inside the Canyon of the Guaitara River located in Colombia, South América. by joshua royal on Flickr
El Peñol de Guatapé, Colombia
Travel Colombia Itinerary http://www.sarepa.com/2015/11/16/colombia-travel-itinerary-what-to-do-for-3-weeks-in-colombia/
The laneways of Cartagena, Colombia- one of the most beautiful cities in South America!


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Randolf Richardson" <rand...@modperl.pl>
|Re: external process
|Tue, 19 Jun 2012 17:17:23 GMT
> I'm having trouble with running an external program. It seems to work the > first few times I do it, then it gets stuck and I have to restart httpd > with kill -9. I've tried things a few different ways. Here is what I'm > currently doing: > > my $pm = new Parallel::ForkManager(6); > > > for my $thing_to_do(@things) { > # Forks and returns the pid for the child: > my $pid = $pm->start and next; > my $command=q{/public_html/perl/detach.pl}; > $command . ' ' . $thing_to_do; > > `$command`; > ### I've also tried: $r->spawn_proc_prog ($fc); ### > > $pm->finish; # Terminates the child process > } > $pm->wait_all_children; > > > I'm sure this is "simple". Where have I gone wrong? The sample code on this web page helped me: http://perl.apache.org/docs/2.0/api/Apache2/SubProcess.html I'm not sure what "$fc" is, but if it is the full command with arguments, then that will not work for arguments needs to be specified separately: # pass @ARGV but don't ask for any communication channels $command = "/tmp/argv.pl"; @argv = qw(foo bar); $r->spawn_proc_prog($command, \@argv); The above example comes from the above page, and it will run the process as detached. In some environments the command needs to be the perl binary itself (such as Microsoft's Widows) with the script being one of its arguments. Also note that if you shut down Apache HTTPd that your spawned process will also be terminated, but this is trivially resolved by making your process truly detached with the following two lines added appropriately in your "detached" script (I use this in production and find it works very well): use POSIX 'setsid'; setsid(); I'm assuming the "detached" requirement because of the name you chose for your script. If you actually need to communicate with your script (e.g., receive its output, etc.) then detaching from it may not be exactly what you need, and in which case the web page I referenced above explains how to do that with the other examples under the "Synopsis" heading. I hope this helps. Randolf Richardson - email@example.com Inter-Corporate Computer & Network Services, Inc. Beautiful British Columbia, Canada http://www.inter-corporate.com/
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|Nucleic Acids Research
The fruit fly, Drosophila melanogaster, is one of the most studied eukaryotic organisms and a central model for the human genome project. Introduced as an experimental organism in the early years of this century, the genetic prowess of D.melanogaster has placed this fly at the forefront of many areas of research, notably gene regulation, chromosome behavior, developmental biology, cell biology, neurobiology, population biology, ecology and evolution. Beginning in 1992, data on the genetics and genomics of D.melanogaster and related species have been electronically available over the Internet through the funded FlyBase, BDGP and EDGP informatics groups. These groups recognize that many (perhaps all) genome project and community data types overlap considerably, and that it would be of great value to present the scientific community with an integrated view of these data. Beginning in 1998, the BDGP, EDGP and FlyBase have begun the process of merging their data distribution efforts into a single project. In the short term, however, the data will be accessible only through independent servers, and so it is the purpose of this report to describe current aspects of the FlyBase, BDGP and EDGP public databases. However, it should be realized that the merger is in progress, and the specific aspects of database access will be in flux for the next several months. Some new merged efforts are also discussed.
The taxonomic scope of FlyBase is the family Drosophilidae. However, the vast majority of data concerns the one species D.melanogaster.
FlyBase represents abstracted and value-added curated genetic and genomic data from the Drosophila `literature', i.e., from the published scientific literature, accessions from nucleic acids, protein and other databases, written personal communications, and bulk submissions. All information in FlyBase is attributed, meaning that it is attached to a specific bibliographic citation. The current view of the D.melanogaster genome and the functions of individual genes is necessarily incomplete. Given this incompleteness, and the heterogeneity of the literature, it is an important function of FlyBase to attempt to integrate the literature, particularly by the use of structured terminology (controlled vocabularies and nomenclature).
The genetic data sets. FlyBase organizes genetic data in terms of chromosomal locations in the genome, and in terms of the products that the genes encode. Gene descriptions therefore include recombinational, cytogenetic, physical and sequence level information on map locations, functional, expression pattern and structural information on gene products, and biological roles based upon inferences from mutant phenotypes. Information on specific mutant alleles, chromosomal aberrations, transposons and transgenic insertions are also included, as are the strain lists of the publicly-funded stock centers and a few private collections. Because of the importance of related information from other systems, FlyBase includes numerous crosslinks to other databases, such as to accessions in nucleic acids and protein databases, and records of homologs in other species databases. As the FlyBase data set expands, it is becoming increasingly important to provide graphical data summaries wherever possible. Images within FlyBase include regional cytogenetic, physical and sequence level maps, as well as anatomical drawings and photomicrographs.Ancillary data sets. In addition to these core data sets, FlyBase provides other services to the scientific community. Contact information for the Drosophila community is available. Sets of data that are not themselves curated by FlyBase, but that may be of interest to the community are maintained in an Allied Data division of the FlyBase server. These data are posted directly in the form submitted to FlyBase. Most notably, in its Allied Data section, FlyBase mirrors `The Interactive Fly', a database of gene products and pathways produced by Tom and Judy Brody. In collaboration with the Brodys, FlyBase maintains a hierarchically organized index of cross-links between The Interactive Fly and FlyBase gene reports. FlyBase identifier numbers. Many data classes in FlyBase have unique identifiers in FlyBase. These allow FlyBase data objects to be cross-referenced, both within FlyBase and externally. FlyBase identifiers are of the form: FBxxnnnnnnn, where xx is a two-letter code signifying the type of identifier, and nnnnnnn is a 7-digit number padded with leading zeros. For example, a gene identifier would take the form of FBgn0001234, a bibliographic reference of the form FBrf0098765, and an RNA transcript of the form Fbtr0005678. Organization of FlyBase data. Some classes of FlyBase data are completely structured. These include nomenclature, map data, cross-links to external databases and a variety of controlled vocabularies. These controlled vocabularies include those describing the function and structure of gene products, subcellular and anatomical terms for describing phenotypes and gene expression patterns, mutagens, taxonomic species, transposon properties, etc. Other classes of FlyBase data are captured as free text. In general, the intention is that the structured data classes in FlyBase are the best approaches for interrogating the database and identifying relevant information, and the free text imparts additional information concerning these relevant items. While free text searches are available in FlyBase, their results are likely to be somewhat idiosyncratic, since by their nature, use of terminology is not constrained.A new FlyBase data class-annotated gene reference sequences. As part of the expanded project, FlyBase is now curating reference sequences of the genome. These reference sequences are being curated on a gene by gene basis. In these reference sequence reports, typically the reference sequence is based on finished genome project clone sequence. It synthesizes sequence level and physical map information about the locations of transcripts, polypeptides, regulatory elements, mutant alleles, transgenic rescue fragments and other features that can be tethered onto the reference sequence. These data are captured from primary nucleic acids database accessions, from the primary literature and from personal communications. These reference sequence reports will be submitted to GenBank as FlyBase-authored annotated sequences, and will be cross-referenced to FlyBase feature tables. FlyBase attribution. A key feature of FlyBase is a comprehensive bibliography of conventional and unconventional publications (e.g. films, archival material and even newspaper articles) on the family Drosophilidae, covering all aspects of its study. This bibliography includes the complete texts of all of the published Drosophila bibliographies, and information from major external resources, such as MEDLINE, BIOSIS, the Zoological Record and the Environmental Mutagen Information Center (by permission). The bibliography is updated from these and other sources. To ensure consistency there is a satellite file of all `multi-publication' sources, e.g., journals and edited publications, which includes full names, dates and places of publication, volume number ranges, and ISBNs or ISSNs and CODENS. By far the greater part of these data have been checked on the Library of Congress and British Library online catalogs. Bibliographic records are coded as to type (e.g., journal article, abstract, review, thesis, book, film).
FlyBase maintains a collection of offprints of publications on Drosophila, housed in Cambridge, UK. This collection is cross-referenced with the bibliography, and copies of obscure publications can be supplied on request.
Genomic sequence, clone libraries and physical maps. The BDGP is currently sequencing the euchromatic sequence of chromosomes 2 and 3. Partially sequenced clones are submitted weekly to the Phase 1 High Throughput Genomic (HTG) division of GenBank. Finished clones are submitted to the phase 3 division first as unannotated sequences, and in the near future as annotated entries. Finished clones are being analyzed computationally followed by human curation of those computed results. Sequence data on these clones are available on the Berkeley Fly Database (BFD) server; all available sequence data are in the public nucleic acids sequence databanks (GenBank/EMBL/DDBJ).
Libraries of clones serve both as primary sequencing templates and as reagents to the community. At this time, complete reports about these clones can be obtained only from the genome project Web sites, most completely using the Berkeley Fly Database search tools. There, data are available on the BDGP bacteriophage P1/BAC (bacterial artificial chromosome) clones and physical map, the EDGP cosmid/BAC clones and maps, and YAC (yeast artificial chromosomes) clones localized to the genome by in situ hybridization.
Data on STS's, also deposited in the dbSTS section of GenBank, are available on the genome project servers. Sequence tagged sites (STSs) are short sequences that were used to detect clone overlap and thereby, to construct the physical maps. Most come from sequencing of the ends of genomic clones, but others come from the sequence of known genes or regions flanking P element insertions.Expressed sequence tags (EST) and full length cDNAs. The EST section of FlyBase links to data from two different BDGP projects: the large BDGP/HHMI project sequencing the ends of cDNAs from libraries with a high percentage of full-length clones, and a small-scale project analyzing cDNAs derived from membrane-associated polysomes.
The BDGP/HHMI full-length cDNA EST project's goal is to sequence the 5[prime] ends of 80 000 cDNA clones made from high quality Drosophila cDNA libraries. The long-term goal is to generate the full-length sequence of representative clones for each gene and compare them to the genomic sequence to generate a transcript map of the genome. These full-length sequences will be available for querying and are being submitted to GenBank.
The membrane-associated embryonic cDNA clones, which are in general not full length, have been analyzed by whole embryo in situ hybridization. Data from this library can be queried for clones expressed in particular tissues using the FlyBase controlled vocabularies.Insertion lines. In order to correlate genetic and molecular maps of the genome the BDGP is characterizing Drosophila strains containing insertions of two types of P transposable elements. The first are insertions of P elements that have been selected because the insertion results in a readily detected phenotype such as lethality. The second are insertions of elements that allow controlled misexpression of a gene at the site of insertion. Flanking sequence data and phenotypic data, and in some cases expression data, are collected from these lines. The flanking sequence data are compared with both the genomic and EST sequences to precisely map insertion sites and to associate the phenotype produced by an insertion with a particular open reading frame.
The EDGP is sequencing the distal tip of the X chromosome from cosmid and BAC clones. Finished clone sequences are deposited in the EMBL DNA Sequence Data Library, first as unannotated Phase 3 sequences and then as annotated sequences, where genes and other sequence features have been predicted by computation. As soon as sequences are annotated, these are curated by FlyBase for identified genes and the relevant genetic information curated in FlyBase gene records.
FlyBase data are organized into a variety of data classes for ease of access. Query tools that permit field-specific searches, combinatorial queries and menu-driven selection of controlled vocabularies are available. A variety of tools permit graphical or textual querying by map location as well. Organized lists of `hits' to a given query are produced, and single or multiple items from these hit lists can be retrieved. Unless the full report of an item is itself relatively short, a summary (brief) report is first produced and the user is provided with several options for more extensive reports. Very large reports, particularly of some extensively-studied genes, exceed 1 Mb in size and might take some time to download. FlyBase is investigating approaches for breaking up such large reports.
Anatomical information (querying for phenotypes or gene expression patterns) will soon be accessible through graphical interfaces in which anatomical diagrams are used to enable queries of expression patterns or phenotypes by anatomical term. Hierarchical views of these anatomical terms can also be used to support expression pattern queries.
There are three methods available for searching and locating reports on the different BDGP data classes: query formulation, graphical browsing or preformatted tables. Simple queries can be made using a standard html form that allows some qualifications on the query. The Java-based graphical views of the genome enable users to search based on cytological or sequence location. Further, users can dynamically enlarge or reduce the view, and select customized subsets of the data classes to be displayed. The tabular reports provide summaries of information on sequencing status.
Reports on all genomic clones (P1, BAC, cosmid or YAC), STSs, and BDGP P element insertions can be found using the BDGP BFD textual or graphical query tools. These reports also link to information and graphical displays of the physical contigs made up of these clones. When available, the sequences of the genomic clones are presented as well as those of large contiguous regions formed by joining the sequences of individual clones.
The `BFD Map Viewers' item on the BDGP home page links to Java displays which allow interactive browsing of the genome at progressively higher resolution. At any level of viewing, from whole genome to the DNA sequence, users can select an individual graphic entity to retrieve a text report describing that data item. In some cases, these text reports operate through links to the FlyBase report of that entity. ChromoView and ArmView show the physical map at any cytological position in the genome, with physical contigs shaded as to whether sequence information is available. These contigs link to the physical map viewer, CytoView, which diagrams the STS links between genomic clones that make up physical contigs. Clones and STSs link to text reports, and the Clone reports link to the CloneView display of the annotated genomic sequence for that particular clone. For those clones inspected by a human curator, the most relevant results for each predicted and previously known gene identified in the sequence will be summarized and labelled with formal gene names or valid FlyBase symbols.
Users typically identify ESTs they are interested in by sequence similarity to a query sequence, for example by using the FlyBase BLAST server. The results of such a BLAST search will hyperlink to `clot' reports for the positive match, a clot being a group of cDNA clones with similar EST sequences. A Java alignment viewer in the clot report allows one to inspect the alignment of EST sequences in detail. Since the clots are also analyzed for sequence similarities using BLAST, the results of these searches can also be browsed by querying by key word. Finally, the EST Query page also allows one to access details about an individual clone using its clone or accession number.
The EDGP and BDGP jointly maintain BLAST servers for querying Drosophila sequence data. These servers are available from the EDGP and BDGP home WWW pages. EDGP cosmid and BAC clone data are integrated with the BDGP clone data, and can be accessed from the BFD search page.
The independent FlyBase, BDGP and EDGP servers are gradually merging into a single public database. Integrated reports of genome project and community information will be provided. The details of the layouts and formats of these pages, and the textual and graphical querying and browsing tools will be evolving.
FlyBase is built with a relational database management system (Sybase). The present schema has been implemented for most of the data and most files accessed via the FlyBase servers are the products of the Sybase tables.
FlyBase data are maintained by curators working from the literature and filling in standard forms that are parsed into the Sybase tables.
The BDGP public database (the Berkeley Fly Database) utilizes Informix as its database server. This database is directly accessed from the web via CGI scripts to respond to queries and generate reports. The EST portion of the data is still maintained in an earlier Illustra database and is accessed by the same techniques.
The BDGP data are the culmination and synthesis of output from various laboratory information management systems that rely upon a variety of different technologies reflective of each project's history, these include: Flydb (an ACeDB variant), Filemaker, 4D, Illustra, and Informix.
The EDGP production data are maintained in ACeDB. Downloads of these data are sent weekly to the BDGP and the BDGP reciprocates. These weekly exchanges keep the two BLAST servers and ftp sites in synchrony.
The primary FlyBase server has the following addresses:
|http access
|gopher access
|flybase.bio.edu (in /flybase)
|ftp access
|Email access
Mirror sites are available in Europe, Asia, Australia and the USA. The FlyBase Views section indicates available mirrors. While network problems can be unpredictable, in general FlyBase recommends that users connect to a mirror site that provides the most rapid response time.
FlyBase WWW access now provides users with the option of customized report formats and database interconnections.
|http access
|ftp access
All sequence data are mirrored at the EDGP site.
Progress, and direct access to sequence data and annotations, are available from http://edgp.ebi.ac.uk/ . All sequence data are mirrored at the BDGP site.
A FlyBase Reference Manual is available from FlyBase servers in html format. A brief introduction, `Getting started with FlyBase', is included as the first section of the Reference Manual. Announcements of major database updates and new tools are made through postings to the bionet.drosophila newsgroup. FlyBase users are encouraged to use this newsgroup to track changes to FlyBase.
Descriptions of the BDGP graphical displays, frequently asked questions about the laboratory projects and methods are available in html format at the BDGP web site. Announcements of database updates and new features are posted on the home page.
Interaction with the user community is vital for the success of FlyBase. We encourage the submission of new data, the correction of errors, and ideas for making this database of even greater use to the community.
Requests for help and questions about FlyBase should be addressed to firstname.lastname@example.com. Reports of errors in FlyBase, or data updates, should be addressed to email@example.com. Mail may be addressed to FlyBase, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. All such mail is automatically sent to all members of the FlyBase collaboration, including the newly incorporated genome projects.
We suggest that FlyBase be referenced as follows: FlyBase (1999). The FlyBase Database of the Drosophila Genome Projects and Community Literature. Available from http://flybase.bio.indiana.edu/ . Nucleic Acids Res., 27, 85-88.
We suggest that the abbreviation FB be used for FlyBase, regardless of the particular FlyBase product.
FlyBase is supported by grants from the National Institutes of Health (National Human Genome Research Institute) and the Medical Research Council, London. The Berkeley Drosophila Genome Project is supported by a grant from National Institutes of Health (National Human Genome Research Institute), the Department of Energy to G. M. Rubin. Funding for the BDGP EST project is provided by the Howard Hughes Medical Institute. The European Drosophila Genome Project is supported by a contract from the European Union (coordinated by D. M. Glover).
This page is run by Oxford University Press, Great Clarendon Street, Oxford OX2 6DP, as part of the OUP Journals
Comments and feedback: firstname.lastname@example.com
Last modification: 9 Dec 1998
Copyright© Oxford University Press, 1998.


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- Doctors
- Saskatchewan
- Saskatoon
- Family Doctors
- Dr. Mark Boechler
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Ratings for Dr. Mark Boechler
Dr.B is professonal, kind,calm, he listens,he doesn't make you feel like you are making stuff up,he believes you. He explains well,he is just the best and I've been to many many before him, I hope he doesn't retire for many many many years . He also will call you at home if you need him too,like who does that...? I could go on and on ....
Dr Beochler is the guy that was in the room when I was born. I absolutely love his personality. (I bug him constantly about not remembering my birthday when he was there!) I also hit on his son vicariously through him as the son is also a doctor and he puts up with it with a lot of good humor. He has dismissed small issues I have had (that haven't turned into anything much) but also can be difficult to get a prescription from when you need it. (my mom jokes about having to see various doctors for a cream for regularly occurring rash because of how small Dr B will allow her to have)
I have been seeing Dr. Boechler for roughly 20 years and have been very lucky to have had his excellent care and advice. He is very knowledgable, caring and a really nice guy
Best Doctor I have ever had. Been with him a very long time, He is a wonderful caregiver.
Dr. B was our family doctor for 25 years. He has always been available, friendly, personable, never rushed us, tried to accommodate us as much as possible, and we liked his care not to over medicate. All was well and good as long as we were dealing with minor medical issues. But when serious medical issues came up, Dr. B seriously failed our family. When I came to him with a lump in my breast, for almost 2 years he continued to assure me that it was "just a cyst", even though I was also complaining of unusual fatigue and some other issues. He finally told me "There's nothing wrong with you. You just need more exercise", which reduced me to tears because it was so dismissive and I just knew something was wrong. Within 2 months I was diagnosed with Stage 2 breast cancer. I stayed with him because I knew he felt bad and I was so conflicted because I had always trusted him and thought so highly of him. After I finished my surgery/chemo/radiation, and was on some cancer related drugs that can cause some nasty side effects, I went to him because there was blood in my stool, which is something that should be thoroughly checked according to the instructions about the drug I was on. Dr. B didn't even do a digital exam and didn't recommend any further testing. He told me he was "99.9% sure it was diverticulitis". Considering he was "100% sure I had a cyst", I was not comfortable with that. I finally decided to look for a new family doctor who I feel much more secure with. My issue was thoroughly checked and I'm so glad I got a new doctor. My otherwise healthy son, who Dr. B brought into the world and who recently returned from college in the United States is the midst of some troubling health problems. He went to Dr. B when he started having bright red blood in his stool. Dr. B did a digital exam and told him he thinks he has a fissure and gave my son stool softeners. Those weren't making any difference so my son went back to Dr. B who increased the dose of stool softeners. My son went back to him 5 times and at no time did Dr. B recommend a blood test nor a stool test nor any testing or thoughts over the course of 2 months. My son ended up in Emergency with bright red blood in his diarrhea and vomiting bright red blood. This was never a fissure. At this point we still don't know what it is and instead of being helpful, Dr. B has been quite the opposite. He has, in fact, largely left my son stranded trying to navigate his own way, with our help, through the medical system. I think Dr. B is a nice man who is good to talk to when all is basically well, but when you have a serious health issue, you DO NOT want him to count on him. Get yourself another family doctor now because you never know when you're going to have a serious health issue and you will NEED someone in your camp. I read a recent review of Dr. B on this site and someone wrote that they think something is wrong with Dr B and that he should get to a doctor himself. I think that's very astute. I, too, worry about Dr. B. I have spent 25 years caring about him as an individual and this lack of due diligence on his part with our family is shocking to me. It makes me think something is wrong with him. I hope he has someone helping him so that he can be the caring, diligent doctor I thought he was ... until that's what my family needed most.
Dr. Boechler has been our family doctor for over 25 years. He is very knowledgeable. I trust him 100%!
Dr. Mark Boechler is a excellent Doctor. Myself and family have gone to him for over 20 years. He is great for all ages, very caring, and never makes you feel rushed. He as gone above and beyond for our family. His front staff is very friendly as well. Dr Boechler is the best Doctor we have ever had. Betty & Brent T
He is the best his one secretary is grumpy!.............
Dr Boechler is very friendly, professional, never in a hurry so it makes me feel that he cares about me -the best doctor I know
Would never recommend him for senior citizens. I collapsed and became unconscious and could not be woken up! He had the nerve to say well these things happen to the elderly. I was flabbergasted to say the least. One of my specialists ordered a head scan and I have tried to have Boechler tell me the results but he continues to be evasive. I had three things to ask him during a recent visit and forgot to mention the last issue. When I tried to bring it up with him on the way out, Boechler told me that he had spoken with me enough for this visit. I have had enough of this guy! I'm looking for someone who will treat me like I am a still a real person who still deserves great care, even while I am a senior citizen. I still count!
Dr. Mark Boechler's Credentials
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- Coventry Health Care
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text: Acute Intermittent porphyria (AIP) is a rare genetic disease which is caused by mutations in the porphobilinogen deaminase (PBGD) gene; one of the enzymes of the heme biosynthesis pathway. Mutations in this gene cause insufficient activity of the protein resulting in partially disruption of heme synthesis. This in turn leads to accumulation of toxic intermediates (ALA and PBG) giving rise to a wide variety of problems including acute, severe abdominal pains, psychiatric and neurological disorders, and muscular weakness. Acute porphyric attacks can be life-threatening and the long-term consequences include irreversible nerve damage, liver cancer and kidney failure. Currently, the only curative therapy is liver transplantation and thus, new curative options are urgently needed. Severe AIP patients are suffering poor quality of life with palliative treatments for the different symptoms including glucose or heme infusions for metabolic replacement and inhibition of toxic metabolic production.About AIPGENE AIPGENE is a European Commission Framework Programme 7-funded consortium (Grant Agreement number 261506) which was put together with the aim to develop the orphan gene therapy drug AAV5-AAT-PBGD (AMT-021) for the treatment of Acute Intermittent porphyria (AIP). The consortium's objective is to contribute to alleviating the negative impact of this disease on the quality of life of the patients and their families. Overall coordinator of the project is the Centre for Applied Medical Research (CIMA) at the University of Navarra, Pamplona, Spain. Apart from uniQure, other members of the consortium are the Clinical University of Navarra, Pamplona, Spain; Karolinska University Hospital, Stockholm, Sweden; German Cancer Research Center (NCT-DKFZ), Heidelberg, Germany; DIGNA Biotech, Pamplona, Spain; Servicio Madrileno de Salud, Madrid, Spain. About uniQure uniQure is a world leader in the development of human gene based therapies. uniQure's Glybera, a gene therapy for the treatment of lipoprotein lipase deficiency has been approved in the European Union, and is the first approved gene therapy in the Western world. uniQure's product pipeline of gene therapy products in development comprise hemophilia B, acute intermittent porphyria, Parkinson's disease and Sanfilippo B. Using adeno-associated viral (AAV) derived vectors as the delivery vehicle of choice for therapeutic genes, the company has been able to design and validate probably the world's first stable and scalable AAV manufacturing platform. This proprietary platform can be applied to a large number of rare (orphan) diseases caused by one faulty gene, and allows uniQure to pursue its strategy of focusing on this sector of the industry. uniQure's largest shareholders are Forbion Capital Partners and Gilde Healthcare, two of the leading life sciences venture capital firms in the Netherlands. Further information can be found at http://www.uniqure.com. SOURCE uniQure B.V.


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I have a My Book Essential. it works on Windows 8, Windows 7 with SES driver devices but it does not worked on Windows 8 1.0. Can you change the driver ?
The SES Driver is needed for specific disk functions related to WD SmartWare. You can try to install the latest version for improved compatibility with Microsoft Windows 8.1:


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What new horizons might open up for Swansea City now they are also getting the hang of winning away? On an increasingly treacherous surface they produced another polished performance that lifted them to 30 points and mid-table security.
Appropriately enough during an afternoon-long snowstorm, it was a case of the Iceman cometh. Gylfi Sigurdsson, the midfielder Brendan Rodgers took on loan from Hoffenheim in January, scored one goal, made the other and even popped up with a goal-line clearance.
Beyond his contribution to a frenzied spell of three goals in six minutes early in the second half, the 22-year-old Icelander was the contest's most impressive force. The six-footer has added presence and stature to the silky possession game with which Swansea have endeared themselves to the top flight.
"Gylfi has fitted in perfectly," Rodgers said. "He was a wonderful talent and personality when he was with me at Reading and I stayed in contact with him. As a team, we have come and displayed a lot of what's good about our game."
No sooner had Marc-Antoine Fortuné controlled with his right foot and drilled home with his left to break an uneventful deadlock than Swansea turned their promise into goals. The equaliser came barely 60 seconds later as Sigurdsson checked his stride to stab home Neil Taylor's pull-back at the end of an incisive move. He then provided the excellent right-wing cross that Danny Graham slid in for the 59th-minute decider.
After waiting half a season for a League away victory, Swansea now have two in just over a month, plus an FA Cup success at Barnsley. Albion,by contrast, have lost nine times here in all competitions.
Apart from shaking the snow out of their hair, neither keeper had been greatly occupied in a first half during which any goalscoring threat was largely confined to set-pieces. After Angel Rangel had seen a decent chance blocked by Jonas Olsson, Sigurdsson curled a free-kick wide from 22 yards and Graham turned Gareth McAuley superbly to set himself up for a clear shot that disappeared high and wide.
Albion replied with a posse of corners. Following one, taken on the right by Nicky Shorey, Ashley Williams went unpunished when bizarrely leading with his fist into an aerial challenge. A cluster of Albion players were left appealing, justifiably it seemed, for handball as McAuley's rushed header bounced wide.
Taylor cleared brilliantly from Olsson's header after Graham Dorrans's inswinging kick from the other flank, and Sigurdsson nodded routinely off the line when Fortuné helped another Dorrans corner goalwards.
Almost inevitably, Albion's breakthrough came from this route, Dorrans's 54th-minute delivery from the left being flicked on by Olsson for Fortuné to score his first Premier League goal in more than a year. In the late onslaught, a Fortuné shot squirmed wide off Michel Vorm, then Peter Odemwingie scooped over from seven yards following Dorrans's miscued shot.
West Bromwich (4-4-2): Foster; Reid, McAuley, Olsson, Shorey; Mulumbu (Scharner, 63), Thomas (Tchoyi, 71), Morrison, Dorrans (Cox, 71); Fortuné, Odemwingie.
Swansea (4-3-3): Vorm; Rangel, Caulker, Williams, Taylor; Britton, Allen, Sigurdsson; Dyer (Routledge, 87), Graham, Sinclair.
Referee: Jonathan Moss.
Man of the match: Sigurdsson (Swansea)
Match rating: 7/10
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The landlord does not accept the following in this place:
If all you need is a homely place to set your bags since most of your time will be exploring the city and devoting yourself to your studies with your classmates, take in consideration this well-located apartment right in the heart of the city. Surrounded by everything you might need - such as shops, restaurants, cafes, cultural sights and other awesome hotspots - this flat will ensure you have everything needed within reach. Since you'll stay close to Noviciado metro station, reaching other parts of the city will be easy. Plus, you'll have the advantage of living within walking distance to Universidad Complutense de Madrid - Campus de Somosaguas, Universidad Camilo José Cela, Universidad Pontificia Comillas and Universidad Antonio de Nebrija.
The apartment features four bedrooms, a kitchen and a bathroom. In a nutshell, this could be exactly what you need. So why wait? An adventure is knocking at your door!
Find out more about this property's common areas in our photo gallery.
You will be sharing this property with the landlord.
Family also lives in the property.
Looks like no one had the time to review this place yet!
These conditions were defined by the Provider and are subject to change.
We have not verified this property yet. We are working on having it fully verified as soon as possible.
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At Uniplaces we make the process of booking an apartment as easy as possible for both tenant and landlord.
That's why we have our own team of professional photographers that verify our properties and pick our landlords carefully in order to save time on viewings: we think it's old-fashioned and time-consuming.
You can look at forty different apartments on our platform in the same amount of time that it takes to see a room.
The pictures you see here haven't been photoshopped, so they'll be really accurate.
If you've still got any doubts, we'll keep the money that you transfer us until 24h after your move-in date.
If something's not exactly what you saw online, we'll help you move somewhere else and return your money.
We can only give you the contact details of your landlord after your booking is accepted. But we can guarantee that Uniplaces chooses the landlords it works with very carefully.
Besides, we've had students whose favourite part was living with a local!
Landlords and host families can be great city guides, help you out with translations and even become your friends.
As soon as your booking is accepted, you're given the landlord's contact details. Then, you can discuss all details directly with them, such as when you'll be moving-in.
Students move in and out at different times, so your flatmates might change during your stay.
It's a great opportunity to make new friends!
We personally speak to students who we place in Uniplaces apartments and are sure we will find the right place for you as well!
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By clicking on "Deposit" at the bottom of the offer page you will get more information about each type of deposit.
In general, the deposit is paid to cover for any potential damages that may occur during your period of stay or will be used as rent compensation in case you leave earlier than originally planned.
If no damages occur and you leave on the agreed move-out date, your deposit should be refunded by the landlord in a way you both agree on.


text:
Having problems with your Fuji Finepix S5800 Digital Camera ?
Catalog Hi , i need a catalog for my cam fuji finepix s 5800 Thank you Mahmoud El Baz
Answers :
Hi there,
\015\012you should be able to go online on the fuji website and download this.
\015\012Good luck. Let me know if any problems and I will search and locate for you. Alternatively look on ebay o purchase.
\015\012Kindes regards.
\015\012you should be able to go online on the fuji website and download this.
\015\012Good luck. Let me know if any problems and I will search and locate for you. Alternatively look on ebay o purchase.
\015\012Kindes regards.
Repair Help & Product Troubleshooting for Fuji Finepix S5800 Digital Camera
Tips for a great answer:- Provide details, support with references or personal experience .
- If you need clarification, ask it in the comment box .
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Suggested Questions/Answers :
Catalog Hi , i need a catalog for my cam fuji finepix s 5800 Thank you Mahmoud El Baz
Hi there,\015\012you should be able to go online on the fuji website and download this.\015\012\015\012Good luck. Let me know if any problems and I will search and locate for you. Alternatively look on ebay o purchase.\015\012 ... Fuji Finepix S5800 Digital Camera
I need access to the download software or drivers for my Fuji Finepix V10 digital camera. Any ideas where I can find it..The Fuji site doesn't seem to be much help. Thanks. Rk
Hi,\012Please get it here:\012www.fujifilm.com/support/\012\012www. ... Fuji FinePix V10 Digital Camera
I need d sofware for fuji finepix A400 digital camera asap thanks
Download it from Fujifilms website http://www.fujifilm.co.uk/consumer/digital/digital-cameras/fun-and-easy/finepix-a400/Support ... Fuji FinePix A400 Digital Camera
Fuji/USB Hi folks, Could any of you folk tell me if the Fuji cam will talk to Windows95 via the USB cable direct from the camera, or do I need to download via a card reader? Some chain stores say it will others say it will not! Many thanks.
In general W'95 does not support USB. Only some OEM W '95 versions do support USB, support comes from the computer maker in that case.\015\012\015\012Since the card reader with W '95 should be the serial type Floppy Disk Adapter of PC Card adapter wi ... Fuji FinePix 2600 Zoom Digital Camera
I have lost my original set up dixc for my fuji finepix f10 camera, my old computer quit on me, the one I had used for the pics, and now I can't find where to get the original software to reload on the new computer. Also the new comp uses the vista system so I will also need a program to reformat the original. Gets confusing!! Thanks Jan portgerfield
Hi,\015\012\015\012You can purchase the Finepix software disk from Fujifilm webstore by clicking this link. You can also place an order by phone by clicki ... Fuji FinePix F10 Digital Camera
I need a battery compartment cover for a FUJI FINEPIX S9600 ....can you help me? thanks MDERBY
... Digital Cameras
Fuji finepix S7000 the battery cover is damaged, it will not stay closed to hold in the batteries in. its need a new cover where can i get one or get it fixed. thanks
Yes you can get these as repalcement parts by contacting Fuji, or one of theior repair agents, in your country, or you can return the camera to one of the repair agents to get the job done for you. ... Fuji FinePix S7000 Digital Camera
How do I replace the LCD screen on my Fuji Finepix S700? I can get a replacement screen and I am comfortable with replacing it myself but I need detailed instructions. Is there a manual or somewhere online I can find specific instructions? Thanks so much!
... Fuji FinePix S700 Digital Camera
I have a fuji finepix s7500 and zoom error. I dont have warranty so I tried to fix myself. I actually found the problem with the zoom. now I am trying to put it back together and I cant figure out where one piece goes. I need help it wont turn on anymore. Thanks
The trick is remembering how you dis-assembled so you can re-assemble.\015\012Purchase or borrow another camera and photograph each step.\015\012Buy a plastic tray with little compartments in and start at 1 end and then work back when ass ... Fuji FinePix S700 Digital Camera
Need Fuji FinePix 2650 Software
Try the fuji 800 number they may be able to sell you a new driver cd. otherwise you can buy a card reader at any camera store that will eliminate the need for software completely for about $15. ... Fuji FinePix 2650 Digital Camera
I need software fuji finepix s5000 - Fuji FinePix S5000 Digital Camera
You don't need any special software.The best way to download pictures from your camera to your computer involves removing the memory card from the camera and plugging it into a card reader (either built-in to the computer or connected via ... Fuji FinePix S5000 Digital Camera
I need fuji finepix f420 software - Fuji FinePix F420 Digital Camera
You can get your software from here:http://www.fujifilm.com/support/digital_cameras/software/usb/index.html ... Fuji FinePix F420 Digital Camera
Drivers needed need drivers for my ezonics internet camera, (ezonicx EZ-cam model p1ou) 0 0
What version of OS are u Using ... Digital Cameras
Need download manual for the Fuji finepix J10 digital camera
U can download herehttp://www.scribd.com/doc/3497987/Icom-IC910H-Service-manual ... Fuji Digital Cameras
I need a new BATTERY DOOR for my Fuji Finepix S7000. I tried to order just the door from numerous sources & they could not get it (because Fuji insists on me sending my entire camera to them)! This repair would take 60 seconds IF I could just get a door....I finally sent the entire camera to Fuji & they charged me over $100. Obviously the door is flimsy, but I love the camera. Would like to order the door ONLY (and maybe even a spare for future similar problem) Thanx!
I looked up the cover on Ebay, and you can order it here:\015\012http://cgi. ... Digital Cameras
I lost my USB cable and the CD with software. I buy a new USB cable but I can't get the softwere, and I need first FinePix Viewer and I find just FinePix Viewer updater, but what to update if I don't have FinePix Viewer. Whend I introduced the USB cable in PC, my camera is simple shutdown, and the computer it don't have any response, Is that normal? or maybe the USB cable is wrong choice it. Thank you for your assistence.
Use a cardreader to download your pictures. ... Fuji FinePix Z10fd Digital Camera
Fuji Finepix V10 - I need a viewer for Windows Vista
Try installing the software if it does not install then you need to contact fuji support and ask them if they have a software version that is supported on Vista ... Fuji FinePix V10 Digital Camera
Fuji FinePix S5000 stopped taking pictures. Told need sensor?//
CCD failed, replacement needed. ... Fuji FinePix S5000 Digital Camera
Need Fuji FinePix A500 Software
Go to their website, Its a whole lot easier just to get a external card reader or use one thats built in your pc if you have one... ... Fuji FinePix A500 Digital Camera
Cam a fuji finepix a700 camera be used as a web cam?
Hi There\015\012\015\012I have a internet site you can use picasa.google.co.uk I hope it t can be of any use to you. ... Sony Cyber-shot DSC-W55 Digital Camera
I have lost the cd rom for my fuji finepix f460 and am now unable to download from my camera. Can i download from fuji or can i purchase another cd rom ? Many thanks
... Fuji FinePix F460 Digital Camera
I need asembly guide for finepix e550 - Fuji FinePix E550 Digital Camera
Here is a link for you to go to where you will be able to down load your manual. Hope it helps.http://www.fujifilmusa.com/support/ServiceSupportProduct.do?prodcat=789908 ... Fuji FinePix E550 Digital Camera
I need a new lcd screen for my fuji finepix s700, where can I find one??? My lcd screen on my Fuji film S5800 has stopped working. it is white with stream line colours through it. Can someone please help.
Sounds like your LCD screen is broken. Did you drop the camera? You may be able to find a screen or a broken same model camera with a good screen on eBay. Changing it out, however is NOT for the faint of heart. You will need tiny tools to work on ... Fuji Finepix S5800 Digital Camera
Ihave a logitech quick cam that is for win 95 and win 98 the softwre to install it is Quickcam express version 1.50. Can I installl this cam on my computer with win Xp. I have tried to install it and it says I need updates could you please send them to me my email is [email protected] or tell me where I can get the software updates Thank you
You should be able to get the updates needed from http://logitech.com ... Digital Cameras
Sanyo VPC-503 I need to know if there is a link for me to download the software for my sanyo digital camera.For some reasonI can't my CD ROM to open and I need to download it cause I use the cam on there also.You can contactme at [email protected] Thanks Gloria
I have a problem with my camera is given me a decodeErr what can i do ... Sanyo DSC-SX500 / VPC-SX500 Digital Camera


text:
EARTH CITY, Mo. – If the St. Louis Rams' defense had their way, they'd get four turnovers every week and take at least one of them back for a touchdown. Takeaways can cover for a lot of mistakes, and the Rams' plus-four turnover margin last weekend against Houston was a perfect example.
It's not that getting takeaways is necessarily a matter of luck. Linebacker Alec Ogletree's interception return for a touchdown clearly came from a combination of preparation and instinct.
But there's a reason players and coaches always say that turnovers come in bunches. It's because they can also be unpredictable.
With that in mind, the Rams' defense has one glaring area that needs fixing, an area that can be lost in the mix when big plays come like they did against Houston.
"You can preach about having turnovers and four every week and scores, but really those games don't happen all the time," Rams middle linebacker James Laurinaitis said. "So the games that don't happen like that, you've got to stop the run. You can't let teams just dictate when and where they're going to run it."
Run defense has been an ongoing issue for the Rams since Week 3. They had a bit of a reprieve against Jacksonville, allowing 96 yards on the ground, but in the other three games against Dallas, San Francisco and Houston, the Rams have given up 193, 219 and 153 yards on the ground.
After a strong start against lesser rushing attacks in Arizona and Atlanta, the Rams sit 30th in the league in run defense, giving up 130.5 yards per game.
The style of rushing has made little difference. Dallas and Houston attacked with zone schemes emphasizing cutbacks and stretch plays, while San Francisco powered up and mostly ran right at the Rams.
At the root of the Rams' problems have been a few basic breakdowns that continue to pop up: staying sound in assignments, tackling consistently and getting off blocks.
"Certainly a lot of people have a little hand in it and we can all improve on it," end Chris Long said. "They're correctable things, though, we're just working hard to correct them. Imagine when we get locking down the run how good we can be. That's what we need to do."
Part of the issue appears to be some of the team's relative youth in the back seven. Houston's success running the ball didn't seem to be a product of dominating the Rams at the line of scrimmage so much as it was linebackers and safeties being out of position, stuck on blocks or missing a tackle.
"We just had a few guys out of their gaps, and when you've got people coming off the edge you have to play your cutback assignment first," Laurinaitis said. "It's things that are definitely correctable. … It's tough to do in the NFL. It just comes down to guys executing their little one-eleventh. We have each got one-eleventh of this pie we've got to get down, and after you do your job you run to the ball."
On two consecutive plays that netted 45 yards for running back Arian Foster, Rams safety Darian Stewart came off the edge chasing after quarterback Matt Schaub. The problem was that Schaub had already handed off to Foster, who simply took the ball and cut into the space vacated by Stewart for big gains.
That's just an example, and by no means is Stewart alone in the mistakes.
Regardless, as Laurinaitis points out, run defense is an 11-person job. If one piece is missing from the puzzle and the running back finds that empty space, it turns into big plays. The Rams have allowed eight runs of 20 yards or more, the most of any team other than Jacksonville, with four going for touchdowns.
The challenge doesn't get much easier this week against the Carolina Panthers' seventh-ranked run game. Unlike Houston or San Francisco, the Panthers are more varied in how they run the ball because of the number of options – not least of which includes quarterback Cam Newton – they have.
Newton, DeAngelo Williams and Mike Tolbert provide different looks for the Panthers, who can line up in '21' personnel and attack with power or spread things out and run Newton on misdirection out of the shotgun, among other permutations.
"We watched it, talked about it and what we need to do," Laurinaitis said. "It's another huge challenge with Carolina, it will be another week like that. They're licking their chops, thinking, 'If we can keep this game close, we can run the ball,' so we've got a huge challenge.
"If we can stop the run and get turnovers like that, you're looking at a good unit. And we can do it. It's not a thing of we don't have the talent to do it. We just need to all have our responsibilities down and execute."


text:
Men's Natural 5-pocket Calvary Twill Pant
Take on your weekend in style with our Calvary Twill pant, a casual yet polished update to our 5-Pocket Twill pant, crafted in brushed heathered cotton. Cotton. Slim fit; mid rise. 14 1⁄4" leg opening. Belt loops at waistband; zip fly with button closure; classic five-pocket styling; button-through welt pockets at back. Machine wash. Color: natural


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Must Visit
Rajamachi Wildlife Sanctuary is surrounded by dense green forests on all sides. It is located in the picturesque locale of Lonavala, The sanctuary is nestled on the hilly terrains of the Western Ghat in the Sahayadri Ranges and displays its wildlife in a pristine fashion. Nature loving tourists immediately fall in love with this place where the wild animals move freely in their natural habitat.
The Mammoth Indian Squirrel is a major attraction here. The landscape too has a bountiful of rare species of herbs and plants. In short, a perfect location for nature walks, trekking and bird watching.
Tell us what do you think of Rajamachi Wildlife Sanctuary
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