text:
Love, Blood & Tears
Chapter 1:
*Note: Chapter 1 and 2 are more like an extended prologue than anything. I cover a lot of ground in the first two chapters. The story slows down after that. The first two chapters basically cover little aspects that you need to know as the story progesses. Please don't let the first two chapter deter you from reading on. Thank you!
"I'm proud of you kid," said Anderson.
"Just remember you were a human before you were a Spectre, you represent all of humanity with your actions," said Udina.
"I won't let you down," said Shepard confidently.
Anderson stepping down and giving Shepard the Normandy? It didn't feel right to her. Pushing papers wasn't his thing but he wanted to give her every chance to succeed in this mission. She knew how much this meant to him and she wasn't going to let him down. They had to stop Saren, a rogue turian Spectre, from bringing the Reapers back. The Reapers were a threat to all life in the galaxy. Last time they appeared, they wiped out an entire species known as the Protheans. The crew was behind Commander Shepard 100% and failure wasn't an option for them.
It was now her ship to control and she already added three alien species to the Alliance crew; a quarian named Tali, a krogan named Wrex and a turian named Garrus. This did not sit well with Ashley Williams, an Alliance crew member that Shepard had picked up on a previous mission. Shepard ignored it – if Ashley didn't like it – she could transfer to a different crew. Once abroad, Garrus got to work on the Mako, he wasn't considered social by any means. He felt much more comfortable keeping to himself and doing calibrations.
Shepard herself was not social by nature but she knew how important it was to get to know her crew and keep the morale up. Garrus would be no exception.
"Thanks for bringing me on board Commander. I knew working with a Spectre would be better than life at C-Sec," said Garrus. They continued to talk about his work at C-Sec, among other things, and somehow his father was brought up.
"My father was C-Sec, one of the best. He's taken my resignation pretty hard. Do things right or don't do them at all. He talked me out of becoming a Spectre when I was younger. The unlimited power, no accountability, he wouldn't like you Commander – no offense."
"None taken," smiled Shepard. Garrus took notice of her eyes. They were big and green. He remembered once before when looking at her eyes though that they were brown.
"Shepard, your eyes."
"They're green right now but I swore that they were brown."
She chuckled. "My eyes are hazel. They are a mixture of colors. Sometimes they are more green than anything, other times more brown. Depends on my mood I guess." She smiled.
"What's your mood right now?" he asked intrigued.
"Happy," she said as she laughed a little. Her cheeks were turning red.
"I didn't mean to make you uncomfortable. I was just curious."
"It's fine, you don't make me uncomfortable Garrus, not at all. I've got to go check on the rest of the crew. Talk to you later?"
"You know where to find me."
She had felt drawn to him since he came aboard. Her conversation with him only furthered her draw to him. She found herself eager to talk to him any chance she had. Garrus was also puzzled. Why does Shepard show so much interest in me? In a turian? Not that he minded. He actually enjoyed his conversations with Shepard. What is wrong with me? He never conversed this much with anyone and never thought that the first person he would open up to would be her of all people, his commanding officer, a Spectre. Well, back to calibrations…
Wrex was not so eager to open up to the commander but that didn't stop her from asking him questions, trying to get to know him better. Although he did not deny giving her answers, his responses were short – to the point.
Tali was sweet and so excited to be part of the Normandy crew. She was happy to answer any question Shepard threw at her. As Tali talked, Shepard found her mind drifting to thoughts of how calibrations on the Mako were going….
Therum was their first mission together. They had to retrieve an asari doctor named Liara. Seeing Garrus in action, his sniping abilities, he was impressive. Shepard was glad to have Garrus watch her back – he would be going on all missions with her from now on. Shepard herself was impressive in battle. Garrus watched her combat skills, her deadly aim, her lack of fear…she was amazing. Her movements from cover to cover almost graceful. Her long rich chocolate hair had red strands that shined in the sunlight. She did her best to keep her hair back in a ponytail when on missions but it was slowly coming undone. "Garrus!" He snapped out of it. "Sniper in that tower! Get him!" Garrus was focused again on the battle at hand, taking the sniper out with ease. What was that all about? Keep your head focused. He continued to do what he was best at. "Scoped and dropped!"
They finally found Liara trapped in a force field down in a mining cave. They freed her and just in time too – the cave was collapsing! "Go! Go! Go!" yelled Shepard. They barely made it out of the cave in time.
"Great, another alien onboard," Ashley said under her breath.
"Do you have something to say Williams?" Shepard asked snidely.
"No ma'am."
The crew finished their debriefing from the mission and were dismissed.
Shepard had enough of Ashley's remarks and attitude towards the alien crew members she had brought on board and she was determined to put an end it to. She headed down a level to where Ashley was. Garrus was under the Mako and Wrex was working on his armor – she figured both were distracted enough not to take notice of the lashing Shepard planned to unleash on Ashley.
"Do you have something you need to say to me Williams?"
"You haven't exactly been trying to hide how you feel about the crew members I've brought on board. Speak your mind and let's be done with this!"
"I just don't think they should be able to have full access to the ship like they do. We don't know if we can trust them."
"Why? Because they're not human? Is that why we can't trust them?"
"No…but, we don't know them and until we know more about them I just don't think it's a safe move."
"Oh I see….just like I brought you on board without knowing anything about you."
Garrus couldn't help but listen in on the conversation. With his superior turian hearing – it wasn't really hard. What he was hearing from Shepard, made him like her even more.
"Listen Williams, bottom line – this is my ship and I will run it how I see fit. If you don't like it – then leave. If you want to stay then I suggest you keep your mouth shut and don't ever question me again. Understood?"
"Yes ma'am."
With each passing mission, each conversation they had, Shepard found herself drawing closer to Garrus. They had become the best of friends. It came naturally and she felt so comfortable with him. Shepard didn't deny the fact that she was attracted to him. His eyes, his voice, his personality, his bad-ass sniping skills….she was very interested in him. Problem was, Garrus showed no such interest in her. She was flirty when she talked to him, could he not tell? She didn't want to outright be bold about it because if he rejected her, she didn't want things to get awkward. He had become her best friend; she didn't want to mess that up. So instead, she had hoped that he would pick up on her subtle hints and return with a few subtle hints of his own. That did not happen though. Or maybe he did pick up on my hints and he doesn't feel that way and that's why he's not returning the favor. She wasn't going to push it. She was just glad to have a friend in him. Someone with who she could just be herself, Commander act aside.
Kaidan on the other hand, showed much interest in her. She would flirt with him but she didn't really mean it. It was harmless in her mind. Why am I flirting at all? Is this an attempt to get a reaction out of Garrus? She felt bad knowing how much Kaiden liked her and knowing she could not return the favor. She continued her playful banter with him anyways. It was something to do to keep her mind of Garrus. Kaidan was a nice enough guy. Who knows, maybe if I try hard enough, I'll grow to like him instead of pining after a turian I can't have. A turian and a human being best friends? That was amazing in itself. Her thoughts of having more were foolish and unrealistic. She did her best to let it go.
Garrus respected Shepard very much. He looked up to her, she made him better. He loved being around her. Her new founded relationship with Kaidan he was not so found of. Kaidan was an alright soldier but he in no way held up to what he considered a worthy match for Shepard. Although, he honestly couldn't think of anyone he considered worthy. Maybe I'm just being an over-protective friend; I don't want to see Shepard get hurt. In any case, he'd be watching Kaidan very closely…
Virmire had been a terrible mission. Shepard had a painfully hard choice to make – save Ashley or save Kaidan. She chose Kaidan. Shepard took it hard, having to decide who to leave behind; she didn't like having to make those types of calls. Alone in her quarters she broke down. She had always been tough on Ashley. It was tough love and she hoped that Ashley had understood that. Her thoughts were interrupted by a knock on her door. She wiped the tears away and gained her composure and opened the door.
"Garrus!" she said with a sigh of relief. She was happy it was him at her door.
"Shepard," he replied as he walked into her quarters. "How are you holding up?" He looked her in the eyes and could see the tears swelling up. He instinctively reached out to her, quickly pulling her into his embrace. Not a word was spoken. He just held her as she broke down .
"Garrus, I'm so glad you're here. I don't know what I would do without you."
"I'm here Jane, I'm not going anywhere."
She snuggled into his chest. He called me Jane. She quickly realized that this was the most tender intimate moment they had ever had. She didn't want it to end. She wanted it to be more but knew that it couldn't. Garrus has shown no interest and why would he? He's a turian, I'm a human. Besides, I'm his superior, it wouldn't be right.
Garrus held her close, her hair felt silky against his face. Her scent was pleasurable, unique to her. He had never been this close to her skin, never noticed her scent, but now that he had it – he would never forget it. Her skin was so soft under his touch, her skin which looked like it was lightly kissed by the sun. He didn't want to let her go. Spirits! What is happening to me?
*knock knock knock*
"Shepard? It's Kaidan, can I come in?"
Garrus let go of her. "Well, I guess I better leave you two alone," he said reluctantly. He didn't want to leave her. He especially did not want to leave her alone with Kaidan. "I hope you feel better."
"Thank you Garrus." she wondered if maybe he felt more for her. Could he really? She thought hopefully. No! I'm letting my feelings trick me.
Garrus walked to the door and looked back at Shepard. "If you need to talk, you know where to find me. Have a good night." He opened the door to see a very surprised Kaidan. "Kaidan," was all Garrus said as he walked to the elevator. "Hey Garrus," Kaidan replied with a confused and somewhat panicked look on his face. As the elevator doors closed, Garrus had to admit he was amused by Kaidan's reaction.
Shepard was in need of comfort. Comfort she'd been receiving from her best friend before Kaiden interrupted. Now instead of comfort, she was being interrogated.
"What was Garrus doing up here?" Kaidan asked anxiously.
"He was just checking on me, making sure I was alright."
"Oh. I know you guys are close but I just thought that with our relationship…or whatever this is….I don't know, I should be the first to comfort you."
"Kaidan, I'm sorry you feel that way. I don't know what else to say. I'm tired; Ashley's death is reeling in my head. I need time to process everything and get my head right so I can be the commander my crew needs."
"Okay Shepard, I understand. Sorry for adding to your burden instead of relieving it." He put his arms around her – her arms still folded.
"Kaidan, I could really just use some time alone. You understand, right?"
"Sure," he said with a half smile, but she could tell he was hurt.
She felt bad for even pulling him down this path as far as she had. It was wrong when her feelings were not in it. She honestly did try but it just was not happening. She just wanted to be alone if she couldn't be with the one she really wanted.
When this mission is over, I'll talk to Kaidan, let him down gently.
This was it. They were headed to Ilos to stop Saren. It was considered a suicide mission. It would be a couple of hours before they got to their destination. To avoid any last ditch romance effort from Kaidan, Shepard spent time playing cards with Garrus and Tali. "Keelah, not that much longer until we arrive at Ilos. I better go check on some things – make sure I'm prepared," said Tali and she excused herself. Now they were alone…
Jane tried to remain calm but her heart started to pound harder in her chest. They were alone and this was her last chance before this mission to come out with how she felt for Garrus.
"Something on your mind?" he asked her, seeing that she was heavy in thought about something.
"Oh, just headed for a suicide mission, odds against us, with you by my side."
He chuckled. "Wouldn't have it any other way."
"Garrus, I was uh….I don't know how to start this off." She stared into his eyes, at a loss for what to say.
"Jane, what's wrong? You can talk to me about anything – you know that." He looked into her eyes and took notice that they were brown right now. If green is happy, then was does brown mean?
"I'm afraid this time," she said as she looked away.
"Afraid?" he said surprised. Brown means afraid. Interesting.
You can do this! She thought to herself. Tell him how you feel!
"Afraid about how this mission is going to go. I don't want to lose any more of my crew." Coward! She just couldn't do it, not right now.
"Jane, everything is going to be okay. We can do this," he said, gripping her arms. "You've got this covered and I'll be with you every step of the way."
"Thanks Garrus," she said, as she pulled herself into him for a hug.
He held her close and they stayed like that for a few moments without saying a word.
After this mission, I'll tell him. I swear I will.
"We're gonna make it!" yelled Shepard as they drove the Mako full blast towards the Conduit. Saren had already gone through, leaving the Geth behind to stand guard. The Conduit was closing fast. Shepard evaded the geth as best she could and drove the Mako through, just before the relay closed.
They crashed on the Presidium of the Citadel, which was burning and heavily damaged by Saren's attack. Shepard, Garrus and Tali made their way out of the wreckage. They made their way to Saren. Shepard did her best to talk down Saren; to stop him from opening the Citadel up as a mass relay to bring back the Reapers. He was indoctrinated, he had to break free from it. She believed there was still good in him. A trait that Garrus admired about her, even now. Saren started to agree with her and thanked her for freeing him before shooting himself in the head. The fleet engaged the geth drop ships around the Citadel. Shepard made sure the fleet defended the Destiny Ascension that the Intergalactic council members were on. While giving commands to Joker for how to operate the fleet, she sent Tali and Garrus down to make sure Saren was dead.
Suddenly, Saren's body begins to twitch and he turns into what looks like a husk, completely possessed by Sovereign! Shepard used the last of her energy to kill it and collapsed to her knees. Feeling exhausted when the weight was lifted off her shoulders. Mission complete.
"Commander!" yelled Tali. Shepard looked up to see a huge piece of debris heading straight for the Tower. "Take cover!" yelled Shepard, just as it hit.
Minutes later, rescuers entered the Tower looking for survivors. They helped recover Garrus and Tali who were wounded but alive. Captain Anderson was leading the rescuers. He asked Garrus where Commander Shepard was. Tali looked sadly across the Chambers; over to the debris….it would have crushed anyone standing under it. A piece of the debris moved….Garrus ran over to it. "Shepard?" yelled Garrus, frantically hoping to find her. Jane emerged with an injured arm and climbed out of the debris, limping towards Garrus, smiling. Garrus pulled her into his arms, looking into her eyes. They were green.


text:
St. Michael's Medical Center, Newark, NJ
PURPOSE:The aim of this study was to determine the effect of training in self-management on patients admitted with COPD exacerbation.
METHODS:This is a single center, prospective study carried out involving 92 patients admitted for COPD exacerbation. Equal number of study participants were assigned to the usual care group and the intervention group who received a modified version of disease-specific self-management program, "Living Well with COPD".
RESULTS:Most patients in the study were elderly, Afro-American, and with low educational attainment. Half of the patients have either MEDICARE or MEDICAID, and two thirds of the patients have previous hospital admission within a year for COPD exacerbation. Three months after hospital discharge, the COPD patients who received self-management training have better compliance with outpatient follow-up than the usual care group. COPD patients in the self-management group also had significantly better SGRQ score as compared to the control group. Determinants of outpatient compliance included having higher educational attainment, having a previous hospitalization, and being a patient in the pulmonary clinic. Moreover, patients with lower lung function and poorer SGRQ score were also more likely to comply with out-patient follow-up.
CONCLUSION:In conclusion, this study demonstrated the positive effect of self-management skills among patients admitted with COPD exacerbation on compliance with outpatient follow-up. The study also showed that self-management programs can improve the quality of life of patients with severe COPD three months after hospital discharge.
CLINICAL IMPLICATIONS:The present study supports the use of self-management program as an integral part of the long-term care of patients with advanced COPD.
DISCLOSURE:Roberto Santos, No Financial Disclosure Information; No Product/Research Disclosure Information
Wednesday, October 29, 2008
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subset: commoncrawl


text:
It was one of the rare occasions LeBron James has been shown up on the highlight reel, and the video of the play has had hundreds of thousands of views online.
Rudy Gay scorched the Miami Heat star with a behind-the-back dribble and threw down a monstrous dunk, leaving James rooted in his spot, and the TV broadcaster hollering "Oh my goodness, Rudy Gay took LeBron James to school!"
It was last November, and Gay was with the Memphis Grizzlies at the time. But it's clear the Toronto Raptors small forward doesn't back down when it comes to battling LeBron.
"I'm a competitor. What competitor doesn't like to play against the best? I don't know many," Gay said with a shrug Monday.
The Raptors (2-1) host the two-time defending NBA champion Heat (2-2) at the Air Canada Centre on Tuesday, and the inevitable question arose at practice Monday: How does one stop James?
While coach Dwane Casey answered, half-jokingly "You hope and pray," Gay wasn't so generous about the four-time NBA MVP.
"I wouldn't say all that," Gay said. "He's a great player, you can't take anything from him, but I'll try my best, use my length and athleticism against him, and hopefully it works."
A little praying couldn't hurt, however, against a team that has beaten the Raptors in their last 10 meetings. Toronto's most recent win was in January of 2010.
The difficulty defending James, who's averaging 23.3 points and eight assists this season, is his versatility.
"He's such a multifaceted guy," Casey said. "He weighs 260, 265, and handles the ball like a point guard and shoots the ball like a long range three-point shooter, so he can get you from a lot of different angles, so it's very difficult to do."
Their best bet, Casey said, is getting him off his rhythm, and making him work for his shots.
Gay, who's averaging 17 points and 9.3 boards a night — he grabbed a career-high 15 rebounds Saturday against the Milwaukee Bucks — is co-captain of the Raptors this season with DeMar DeRozan, but he feels he won't need to make much of a pre-game speech before taking the floor against the Heat.
"Honestly, you shouldn't have to say much, this is NBA basketball right here, and if you don't get up for the best, what do you get up for?" he said.
The Raptors meet Miami twice in November — the second game is Nov. 29 in Miami. They play a third time, Jan. 5 at Miami.
When asked if it's better to get a couple of games out of the way early before the Heat hit their mid-season stride, Casey scoffed.
"It doesn't matter," he said. "They're a tough team whether it's today, summertime. . . they're a very good team, and one of the best-coached teams, they're prepared for every situation, you probably could have surprised them with blitzes and zones and that kind of stuff when you first got together, but now there are no surprises with those guys."
Casey is preaching defence-first this season, and has already seen the team make strides just three games in. They lead the league in rebounds. Their best defensive effort was Saturday's 97-90 win over Milwaukee.
"Guys are being tougher, we're team rebounding, we're gang rebounding, everybody is boxing out, everyone is helping each other," Raptors point guard Kyle Lowry said.
"Disposition," Casey said of the difference in his team's performance against the Bucks. "We came out with more of an edge on our shoulder for 48 minutes. That's the way we have to play, we have to play with defence first, get stops, run. . . "
Lowry said the improved defensive effort comes from a familiarity amongst the players.
"So many moving parts," Lowry said. "And this year we pretty much know what we're doing and know the lineups and rotations, so everyone knows each other and knows what everyone's going to do."
The Heat arrive on the heels of a 103-93 win over the Washington Wizards on Sunday, avoiding what would have been a rare three-game losing streak. Miami won with superior ball movement, with nine players scoring and nine players notching assists.
For Toronto's part, when Casey was asked if ball movement was particularly important versus a team as strong as Miami, he replied: "We should be moving the ball whether we're playing Miami or Ryerson University.
"We should be doing the same thing. . . move the ball, be strong with the ball, multiple passes, as many passes as we can. Defensively, close the gap, and when the shot goes up, box out. All the fundamentals, they don't change."Report Typo/Error


text:
Mr Lover Lover
17th January 2012 - 14:41 | London UK, west london | Age 28
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Ad No: 3920 | Views: 804 | Replies: 4 | Report Abuse


text:
Morley MI Real Estate & Homes for Sale
13 Properties Found
The median home value in Morley, MI is $85,950.
This is
lower than
the county median home value of $99,000.
The national median home value is $185,800.
The average price of homes sold in Morley, MI is $85,950.
Approximately 66.93% of Morley homes are owned,
compared to 25.59% rented, while
7.48% are vacant.
Morley real estate listings include condos, townhomes, and single family homes for sale.
Commercial properties are also available.
If you see a property you're interested in, contact a Morley real estate agent to arrange a tour today!
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405 6th Morley, MI 49336
Courtesy: RiverTown Real Estate Cindy Crawford
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Beautiful 2 bedroom, 1 bath house, located in the village of Morley. Almost 4 acres with a 2 stall garage, and an added screen porch to enjoy your morning coffee or evening meal in. Enjoy entertaining in the huge, nicely shaded back yard. The kitchen, dining and living area offer a cathedral ceiling that opens up the whole space. Basement has a large rec room area, and two additional rooms that can be converted into additional rooms. Updates on home new steel roof on house and garage, garage resided, newer water heater and high efficiency furnace.
22654 3 Mile Morley, MI 49336
Courtesy: Century 21 White House Realty Matt Lauckner
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Here's an affordable opportunity at hunting property- nestled across the road from state land! This 3 bedroom 2 bath home sits on 20 acres of private land with plenty of wildlife- whitetail deer, turkey, bear and woodland birds. Home features spacious living area for entertaining, adjacent to kitchen area with breakfast bar. Master bedroom suite includes private bath with garden tub and walk-in closet- and two spacious additional bedrooms.Exterior features include 24 x 24 pole barn with concrete pad and electricity. Exterior electric back up switch available for gas generator. Screened in porch for exterior living space off kitchen, and small livestock structure ready for chickens!
16000 5 Mile Morley, MI 49336
Courtesy: Big Rapids Realty Laura Veersma
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One of a kind 40 acre property with 3 bed, 3 bath home PLUS rustic bunkhouse forguests. Property has been successful at managed hunting. 3 levels of finished sq ft to give you 2400 sq ft of living space.
16000 5 Mile Morley, MI 49336
Courtesy: Big Rapids Realty Laura Veersma
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One of a kind 80 acre property with 3 bed, 3 bath home PLUS rustic bunkhouse forguests. Property has been successful at managed hunting. 3 levels of finished sq ft to give you 2400 sq ft of living space.
2560 172nd Morley, MI 49336
Courtesy: Berkshire Hathaway HomeServices Michigan Real Estate (Rock) Kamie Jakeway
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Affordable Country Living in Morley on this 2-acre ranch home. 3 bedrooms 2 full baths, 1344 sq ft on the main floor with all kitchen appliances. Home was built in 2002 and has an unfinished basement, 2-stall attached garage and a covered front porch.See attachment for PAS requirements and WFHM offer submittal information in MLS document section.
264 N Cass Morley, MI 49336
Courtesy: Midwest Prop of Michigan(Main) Michelle Newell
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HOME CLOSE TO IN TOWN AMENITIES with 4 bedrooms. Beautiful natural wood still in the home. This is a home that needs someone that likes to redo homes and has a flare for that. Full Basement that walks you up to the attached garage. Home is waiting for a talented person, that has ambition to make this home their own. Year of home is approximate. Home is being sold ''as is''.Give me a call for your private showing.
11379 5 Mile Morley, MI 49336
Courtesy: Peacock Real Estate Mary Peacock
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3 bed/1 bath 2 story home on 5 lots. Open floor-plan, large rooms, and many updates. Some updates include: 98.5% energy efficient furnace installed in 2015, outside mortar on home, windows, flooring, paint and more. Large yard and deck, perfect for entertaining family and friends. Centrally located between, Morley, Stanwood, Mecosta and Canadian Lakes. Within walking distance to the Little Muskegon River.
21487 Jefferson Morley, MI 49336
Courtesy: RE/MAX United (Main) Carrie Spray
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Tons of possibilities! Affordable 3 bedroom 1 full bath home with pole barn on just over 2 acres. Dreamed of owning your own business? Move right in and get started. Zoned commercial. Perfect location on main road just off the highway with an easy commute to Grand Rapids. Don't wait. Call today for your private showing.
4076 220th Morley, MI 49336
Courtesy: Keller Williams GR East Linda Pell
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Red cabin in the woods: The perfect hunter's getaway! 560 square feet of living space, including a lounge, eat in kitchen with appliances, a full bath & a bedroom. The exterior is painted with newer asphalt shingles, vinyl windows and well (2012) & septic & drain field (2013). This is the place for target shooting, late night gatherings around the fire pit and indoor card games when the weather doesn't cooperate. Propane runs the newer wall furnace and is connected to the mini water heater. It's the perfect size for relaxation and rest. Located on a 2.5 acre parcel and minutes away from Brower Park & Hardy Dam.
12650 Jefferson Morley, MI 49336
Courtesy: Lake Michigan Realty Mgtmt Javier Rodriguez
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Ten Acres Of Nice Land. Land may be split into two five acre parcels. Keep existing home as a future rental and build a dream home on other 10 acres. Live In All Year Round Or Use As A Weekend Getaway. Great Hunting Land Or Use As Farmland. Older Single Wide On Property.
199 125 Th Morley, MI 49336
Courtesy: Coldwell Banker Lakes Realty Todd Lincoln
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74 Acre Farm Estate is being offered for sale for the first time. This 3 bedroom home has been vacant for the last 5 years. Tillable acreage has been leased for ground crops every year. Barn, Quonset hut and 2 car detached garage complete this package. Property is being sold As Is.
Courtesy: NON Member Office WCAR Beth Fall
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Two bedroom, one bath cottage with nearly 150 feet of frontage on private, all sports Brady Lake in southern Mecosta County. The home has a functional layout with a very spacious entryway with laundry and ample storage. From the open kitchen into the living room, enjoy remarkable views of Brady Lake. The half+ acre parcel consists of 6 lots, three lakefront, three across the road where the garage is, totaling over a half acre! The garage is two stall and two story perfect for parking and seasonal toy storage and additional room for an art studio or office space on the upper level. The home needs TLC, but what's a little work when you have those gorgeous lakefront views and the luxury of year-round play and fishing!
Courtesy: Big Rapids Realty Brooke Iltis
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Well maintained 2 bedroom, 1 bath. Completely remodeled in 2008 including new roof, electrical, siding and windows. Home sits on Morley Pond with tranquil views of the water. Walking distance to all the Village of Morley has to offer! Property makes excellent rental income to those interested in owning a newer remodeled property. Enjoy the back yard, plenty of room to gather with friends and family. 1 stall attached garage. Call Today! Must see this property!
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text: August 20th 2011 Haley Whiteley "Vision is Great! Their staff is super friendly and make you feel right at home! They have very talented photographers and all their pictures turn out great! Thanks so much for everything!" ~Haley Filed in | Louis Palmer, Senior Pictures« Matison CrossDaniel Arrants »bda no comments Your email is never published or shared. Required fields are marked * Name * Email * Website Comment Notify me of follow-up comments by email. Notify me of new posts by email.


text:
Letting go.Mature
If I held a gun to my head,
who would cry and beg me not to?
If I climbed to the roof of a tall building,
who would call up and demand that I don't jump?
If I put a bottle of aspirin to my lips,
who would take them from me and listen for once?
If I laid down on the tracks,
who would scream and drag me off?
If I tied my own noose,
who would hold me up saying 'Don't'?
If I was on the edge of a bridge,
who would grab my hand, pull me back, and whisper 'I need you'?
It took that for you to pay attention,
to see that I'm hurting and broken.
But once I hold that gun, I'll pull the trigger, once I climb to the roof, I'm jumping off, once I unscrew that bottle, I'm drinking from it, once I lay down, I won't get up, once I tie my noose, I'll hang from it, once I'm at the edge...
...I'm letting go.


text:
This is another one of those 'only in Australia' comic books. Seriously. It's one of the most impressive books you're likely to find for one brilliant reason - the comic is the same size as a standard original art page. Thus the pages in here, and the bulk of them are black and white, are as close to the original art as you're likely to see, and when you see what's in the book, well you'll understand why copies of this sucker get snapped up a fair bit.
The book reprints all of the contents from DC Special #21, with some added extras. Inside you have, in order:
Star Light, Star Bright...Farthest Star I See Tonight! by Paul Levitz, Jose Luis Garcia-Lopez & Dick Giordano (DC Special Series 21)
The Fawn and the Star by Michael Fleisher, Dick Ayers & Romeo Tanghal (DC Special Series 21)
They Call Him Hawkman by Paul Levitz & Joe Kubert (Detective Comics 500)
Who Haunts This House? by Denny O'Neil, Joe Staton & Frank Chiaramonte (DC Comics Presents 19)
Whatever Happened To Hourman? by Bob Rozakis, Charles Nicholas & Joe Giella (DC Comics Presents 25)
Take Me Out Of The Ballgame by Bob Rozakis, Marshall Rogers & Terry Austin (Detective Comics 466)
The House of Mystery by Bob Rozakis, Romeo Tanghal & Dan Adkins (DC Special Series 21)
A New Costume For Air Wave by Bob Rozakis, Alex Saviuk & Frank Chiaramonte (Action Comics 511)
Superboy's Amazing New Power by Cary Bates, Kurt Schaffenberger & Dave Hunt (New Adventures of Superboy 11)
Case of the Curious Castaway by Gerry Conway, John Calnan & Vince Colletta (Superman Family 196)
The Longest Night by Robert Kanigher, Dick Ayers & Romeo Tanghal (DC Special Series 21)
Wanted: Santa Claus -- Dead or Alive by Denny O'Neil, Frank Miller & Steve Mitchell (DC Special Series 21)
Plus a few games and other little activity pages.
This sucker came out in 1982 according to the Aust DC Reprint Site, and priced at $2:00 I still would have left it on the shelf. But truth be known until last year I'd never seen this book so who knows if I'd have bought it or not. By 1982 I was making a bit more money than 1979 when I saw the giant Superman book, so I might have bought it. I guess I'll never know.
What was I buying back then? Books and piles of them. The local library was still selling books, only due to inflation the prices had gone up from 5 cents per book to 10 cents. Bastards! Still the comics down at the Elizabeth South Second Hand Shop (still there amazingly enough, although it's gone through several owners and no longer has 5 cent comics) were still very low priced - 5 cents for as many as I could carry without covers, 15 cents for comic books with covers. Yep, you read that right. By 1982 they'd allow me to plonk down a little bit of silver and fill my bag up with as many coverless comics and I could stuff into it. But only once a week. Bliss for me. They used to sort the comics well for a general second hand shop, Marvels and DCs with the odd unusual title thrown in, and they'd sort them into groups - all the X-Men would be in a pile, same with Superman, Fantastic Four - you get the idea. I remember leaving behind a copy of X-Men #40 in favour of #94. Beats me where the latter ended up but it's long gone now.
But that wasn't all I was spending my hard earned on. You see at this time I'd discovered movies! At midnight each Friday night in the winter of 1982 channel 7 would show an old Universal Horror film. I saw all of the classics that way - the Frankenstein, Mummy, Dracula and Wolfman series along with gems such as The Old Dark House, The Black Cat, The Raven - basically if it had Bela Lugosi, Boris Karloff or Lon Chaney Jr in it then they'd show it. So I'd gather myself up, get a set of tongs from the kitchen and half a loaf of bread, some butter and settle in. I'd toast the bread in our open fireplace, eat it and watch the movie, whilst taping it on the slab of concrete we called a VCR. Those days were pure bliss.
Even better was to come. On Sunday nights a cinema group would show classic movies at the Shedley Theatre. The movies cost 50 cents each and they'd show anything that they could find. A lot of them came from a private collection and as a result I'd see some brilliant silent movies - Tom Mix westerns, Lon Chaney (Phantom Of The Opera!!), Chaplin, Arbuckle, Langdon, D.W. Griffin, DeMille - you name it, I saw it. It was only later that I realised that what I was seeing consisted of a lot of movies considered to be lost these days. My mother would palm me a $1:50 and off I'd wander, walk down to the cinema (these were the days when a young lad could walk the streets in relative safety at night), buy my ticket, get a bottle of drink and a bag of crisps and settle in. I was the youngest there and possibly the only person under the age of 60. They'd have an organist who'd play her tunes and look over her shoulder and grin. She always reminded me of Terry Jones doing his Blackmail skit on Python and as such I'd have to stifle a lot of laughs. They showed the films throughout the winters of 1982 and 1983 and then stopped. Pity
Those days were heaven for me and I do look back on them with a certain longing. They did instill in me a life-long love of cinema, classic cinema, and I've often thought that one day I might hire a theatre and do the same kinds of shows myself and see if I can't pass that love onto some young thing somewhere. But then I doubt many people would be interested in them anymore. People ask why do I write about comic books? There's your answer - because the comic books always, ALWAYS, lead me to other happier places. It's as simple as that really.
Controversial! Fun And Also Games! First Comic Book related blog to be featured in the Australian National Library's Pandora archive. 2016 Rondo Award nominee. Pop culture, music, film and comic book expert. Would be willing to write for biscuits.
Logo and banner designed by the amazing Michael Netzer.
Monday, February 19, 2007
Super-Star Holiday Special!
Posted by Daniel Best at 8:35:00 am
Labels: Australian Comics, dc comics
2 comments:
- Bronze John said...
I reckon a pizza-red wine- movies like this night should be a goer.
- Monday, February 19, 2007 8:36:00 pm
- Danny said...
I'd be in it - and I've got a pile of Universal Horror flicks to watch.
- Monday, February 19, 2007 9:29:00 pm
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Fuse Creativity System Project Guide: Fun Party Themes, Idea for Handmade Cards, And More Paper Crafts from Fiskars
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"My cats love these. They are quick and simple to make. For anyone unfamiliar with the yarn that is suggested for the pattern, it is a fingering weight, 4 ply yarn that is 100 percent cotton. I used worsted weight and a 3.5mm hook for mine, so I wouldnt have to worry about the cats pulling the stuffing out through any holes."
"The name is very attention getting with the recent death of Prince. The link to the crochet pattern takes me to a different posting on this site where the project is included within a free ebook with 16 other easy crafts. There you can download the entire ebook as a pdf in order to get the pattern."
"The name is very attention getting with the recent death of Prince. The link to the crochet pattern takes me to a different posting on this site where the project is included within a free ebook with 16 other easy crafts. There you can download the entire ebook as a pdf in order to get the pattern."
"What does (K1. Inc 1 st in next st.) mean? I think st means stitch, but I don't understand how to do what it says. Thank you "
"This is absolutely stunning! I love it. I love vintage China and this is one way to display it. For my own personal taste I would use less pieces in the back, or even paint the background to make it pop more, and use the broken pieces on,y around the border as a type of frame. But that's just me. Alternatively, using less cups and just feature a ew with the broken pieces may set them off better. But all in all this is a great idea and display! Love it!"
Fluffy Pink Feather Wreath
By: Kathleen George for STYROFOAM Brand Foam
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Brighten up your front door - or your baby girl's bedroom door - with this fun, fluffy pink feather wreath. Certain to elicit smiles, this project can be recreated in red or green to celebrate Christmas.
STYROFOAM™ Brand Foam:
- Wreath, Round Face, 12" x 2-1/2" x 1"
- Thick, white craft glue
- Low-temp glue gun and glue sticks
- Scissors
- Ruler
- Pink marabou feather boas, 6' long, two
- Contrasting feathers, one package
- Metallic mini glass ball ornaments, 15
- Coordinating wire-edged ribbon, 1" x 1 yd.
- Wire or ribbon, 6" length
Beginning around outside edge, use glue gun to dab foam wreath with glue before pressing boa to surface. Work small areas at a time to prevent glue from drying too quickly. Continue in circular fashion until entire surface is covered; trim excess boa.
Tie 1"-wide ribbon into a bow at center. Glue bow to center bottom of wreath; trim excess.
Use glue gun to secure tops of mini ornaments to wreath in four groups as shown; let dry completely. Use white glue to secure feathers around ornaments; let dry.
- Twist wire ends, or knot ribbon ends, together to create hanging loop. Glue ends into center top back of wreath.
®™ Trademark of The Dow Chemical Company ("Dow") or an affiliated company of Dow. For more project ideas, please see styrofoamstyle.com.
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Feb 28, 2013
I absolutely love this! It's about time I found a grrrreat looking craft with feathers!!!! Thank you!,
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At Anax Resort & Spa, you can hit the beach to enjoy the shade from a beach umbrella or relax in a sun lounger, plus you'll be within a 15-minute drive of Windmills of Mykonos. The outdoor pool provides fun for everyone, while guests in the mood for pampering can visit the spa to indulge in facials and mani/pedis. Kyma, one of 2 restaurants, serves Mediterranean cuisine and is open for breakfast and dinner. There are 2 bars/lounges and a free airport shuttle, and rooms at this luxurious hotel get the details right with jetted tubs and hydromassage showerheads.


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Whether lounging on the sand or changing in the lot, the Channel Islands Flag Beach Towel is certain to become your favorite beach accessory.
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- One sided print
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The Luxury Visionaries 2016
Land Rover is set to float a whole raft of ideas at the New York Auto Show next week as it sets about buffing up the Land Rover side of its business to shine as brightly as its Range Rover franchise.
If you have recently tried to buy a new Range Rover Sport, or a "big" Range Rover and even a "little" Range Rover Evoque you will know this is no small undertaking. There are serious waiting lists right now for most everything branded with the Double-R. In the luxury car business, Range Rover is the gold standard.
Meanwhile there hasn't been a new Land Rover since 2006. Some freshening, some concept thinking and an announcement that the Land Rover (latterly the Defender) would finally die next year at the age of 67 with no apparent heir installed. All of that, but no new Land Rovers. It's been one new Range Rover after another, but that is set to end next week with the launch of something called "The Discovery Vision Concept." And this is an interesting one.
Land Rover's official line is that the concept, seen here emerging with uncharacteristic restraint from the shadows "demonstrates a design vision for a future family of premium SUVs". "Family" is the key word there. This isn't a sneak peak at the new Discovery, because there won't be a new Discovery. There will instead be a whole family of them, bigger ones, smaller ones, sporty ones and so on. The range will include the replacement for the Freelander, currently Land Rover's only truly humdrum car. It's likely the next generation Freelander will be the first to see the new design language previewed on the Discovery Vision and that could be as soon as next year.
Car designers love to talk about "design language". It's the lexicon of surfaces (the play of light and shadow on a car's body), the graphics and the rules on items such as proportion and stance that ensure carmakers' products all look familiar. (You don't, for example, actually need to see the overlapping rings on the front of an Audi to tell it's an A, R or S-something behind you). And you certainly don't have to speak fluent Land Rover too see the Range Rover, the RR-S and the Evoque are very clearly cut from the same cloth. Some might say the latter two share the very same fabric, just fashioned in different sizes.
The Evoque came first of course, meaning that the fizzy little boutique car (originally designed as a Land Rover product) lent its look to the much bigger Range Rover, one of a select group of peerless icons inside the car industry (Porsche 911, S-class Mercedes and VW Golf being some others) and a cornerstone of Land Rover's business. That was brave.
This time around there is every chance all the cars in the new Discovery franchise have already been imagined; this certainly feels like very strategic play from Land Rover — it has after all had long enough to plan it. As well as boosting the new franchise and showcasing the new look the Vision Concept also boasts some nifty technology including the "transparent bonnet", an augmented reality concept that uses low-mounted bumper cameras and head-up display unit to put in the driver's line of sight an image of what's under the car's hood. Away from the highway, and especially climbing, it's a very cool tool.
"Discovery" then is the name you'll need to know if you don't necessarily want your Land Rover dressed to kill, yet nor do you much fancy it in wellies and a waxed jacket. Discovery is of course the name that currently graces what is to many — me included — the firm's finest car. The Discovery, currently in its fourth generation has been around in this form since 2004. Overweight and thirsty yes, but usable and useful beyond comparison and devoid of the old money/new money/stolen money luggage the Range Rover carts around. It just is.
Much of that comes from the execution of its design, one of the boldest yet purest shapes to ever grace a production car. And it's not aged a day in 10 years. Few cars have ever met with such approval from the wider design community. It was always going to be one hell of an act to follow. Fitting then that its legacy will be a more than just another new generation Discovery, but an entire new generation of Discoverys.


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Coastguards and police who were searching for a yachtswoman who tried to sail her boat solo around Land's End in the dark have found wreckage off the Cornish coast.
Mary Unwin, 65, ignored advice not to attempt the voyage in rough seas and set off from the Cornish village of Mousehole trying to reach Bideford in north Devon.
On Monday afternoon, almost 48 hours after she set sail, wreckage was found at Sennen Cove, close to Land's End. Coastguards compared the debris with photographs of Unwin's nine-metre (31ft) yacht, Seagair, and concluded it was very likely they had found the remains of her vessel.
There are many hidden rocks and reefs off that stretch of coast and it seems likely the yacht struck one in the dark and was broken up in heavy seas. An air and sea rescue operation was called off as it was judged there was no chance of Unwin still being alive.
As she set sail from Mousehole on Saturday evening a fisherman advised her not to attempt the voyage in the dark but she assured him she would be fine. When she failed to contact relatives on Sunday they called the emergency services and an extensive search involving military helicopters, RNLI lifeboats and a coastguard fixed-wing aircraft was launched.
Unwin had bought the £30,000 boat only last week from Falmouth Yacht Brokers. Jerry Hobkirk, the owner of the brokers, said Unwin had been advised to take part in a sailing refresher course before she set sail alone.
He said: "The weather was treacherous, even for some of the more experienced sailors. I simply cannot understand what she was thinking when she left the harbour. I was amazed when I found out that she had set sail. If I had known, we would have stopped her. There were strong winds and rough seas on a piece of coast that has very few escape routes. If you get into difficulties there aren't very many ports to play your 'get out of jail' card with."
Unwin got married less than two weeks ago, in the village of Clovelly, in north Devon, to a man she had previously married and divorced. Before the wreckage was found, the Rev Shirley Henderson, who presided over the ceremony, said she had spoken to Unwin's husband, Carol, who believed his wife was holed up in a harbour somewhere, not realising she was being looked for. "We're all praying she'll be found soon," Henderson said.


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Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne muscular dystrophy (DMD) is characterized by a loss of muscle fibers and impaired regeneration. In this study, we aim to knockdown myostatin by means of exon skipping, a technique which has been successfully applied to reframe the genetic defect of dystrophin gene in DMD patients.
We targeted myostatin exon 2 using antisense oligonucleotides (AON) in healthy and DMD-derived myotubes cultures. We assessed the exon skipping level, transcriptional expression of myostatin and its target genes, and combined myostatin and several dystrophin AONs. These AONs were also applied in the
Myostatin AON induced exon 2 skipping in cell cultures and to a lower extent in the
We conclude that two AONs can be used to target two different genes,
Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder, which is caused by dystrophin deficiency in muscle fibers. DMD fibers are more sensitive to muscle damage, leading to degeneration and replacement of muscle fibers by fat and connective tissue (fibrosis). Monaco
Comprehensive studies done by our group and others have provided the proof of principle of the therapeutic feasibility of the AON to reframe dystrophin transcripts and restore dystrophin synthesis, both
However, other major facets of DMD pathology which include severe muscle wasting, fibrosis and flawed muscle regeneration may reduce the efficacy of the
Myostatin or Growth and Differentiation Factor-8 (GDF-8), an evolutionary conserved TGF-β family member that is expressed predominantly in skeletal muscle, is a potent muscle growth inhibitor. Natural mutations or targeted knockdown in the
A recent study by Dumonceaux
In this study we chose to use 2'OMePS AON to target
Figure 1
Schematic overview of myostatin and dystrophin exon skipping
Schematic overview of myostatin and dystrophin exon skipping. The myostatin gene (
Antisense oligonucleotides
AON with phosphorothioate backbones and 2'-
Table 1
Antisense oligonucleotides used in this study
Sequences (5'-3')
Myostatin exon 2
Myostatin exon 2
Myostatin exon 2
Human dystrophin exon 8
Human dystrophin exon 44
Human dystrophin exon 51
Human dystrophin exon 54
Mouse dystrophin exon 23
Cell culture
Human primary myoblasts obtained from a healthy donor (KM109)
AON transfections
Myotubes were transfected with different dilutions of AON in 0.15 M NaCl using 2.5 μl polyethylenimine (ExGen 500,
Animals and AON injections
All experiments were performed with 5-6 weeks old
In the consecutive injections experiments, cocktails of MSTN or control AONs with M23 DMD AON were injected at the dose of 40+40 μg per injection into the gastrocnemius muscle. Four consecutive injections were performed with a 48 hours resting time between the second and third injection. The mice (n = 6) were sacrificed at 6 hours, 1 and 2 days after the last injection. The muscles were isolated, snap frozen and sectioned. Pool of sections from different area of the muscles was collected for RNA isolation.
RNA Isolation, RT-PCR and Quantitative PCR analysis
Cell lysates were prepared using lysis buffer provided in the NucleoSpin RNA II kit (
Table 2
Primers used in this study
Used for
Mstn Ex1F
Myostatin exon 2 skip PCR
Mstn Ex3R
Mstn Ex1F1
Myostatin QPCR
Mstn Ex2R1
Myog Fw
Myogenin QPCR
Myog Rev
Myf5 Fw
Myf5 QPCR
Myf5 Rev
Gapdh Fw
Gapdh QPCR
Gapdh Rev
DMD Ex6F
DMD exon 8 skip PCR
DMD Ex11R
DMD Ex42F
DMD Exon 44 skip PCR
DMD Ex45R
DMD Ex53F
DMD Exon 54 skip PCR
DMD Ex56R
Myostatin AON induces exon 2 skip
Based on previously described guidelines
To examine the feasibility to induce myostatin exon 2 skipping, different concentrations of each AON were transfected into the myotube cultures using the cationic polymer polyethylenimine (PEI). More than 80% of the cells showed specific nuclear uptake upon transfection with 5'-fluorescein (FAM)-labeled control AON (Figure
Figure 2
Myostatin exon 2 skip in several myotubes cultures
Myostatin exon 2 skip in several myotubes cultures. Human primary control (KM109) and DMD patient derived- (DL589.2) myoblasts were differentiated for 7 days before transfection with MSTN AON. Immortalized control (7304.1) myoblasts were differentiated for 2-3 days. A non-targeting, fluorescently-labeled AONs were transfected as control. Fluorescent nuclei were observed three hours post-transfection (A). RNA was isolated 2 days post-transfection. cDNA was synthesized using random hexamer (N6) primers and subjected for PCR using primers in exon 1 and 3 (B). Note the inverse dose-dependent skips in KM109 samples. Skip fragment was confirmed by sequencing analysis (C). Quantitative real-time PCR was performed using primers in
Additional file 1
Human primary control (KM109) myoblasts were differentiated for 7 days before transfection with 3 different MSTN AONs at 500 and 100 nM concentrations. All AONs were designed to target exon 2 of the myostatin gene. The sequences are listed in table
Click here for file
AON-mediated exon skipping decreased myostatin transcript expression level and increased expression of myogenic regulatory factors
Next, we determined the expression level of
As outlined in Figure
Figure 3
The expression myogenic regulatory factors
The expression myogenic regulatory factors
Dual exon skipping in
Our ultimate goal was to use AONs to simultaneously reframe the mutation in the
Figure 4
Dual exon skipping of myostatin and dystrophin in control cells
Dual exon skipping of myostatin and dystrophin in control cells. KM109 (A) and 7304-1 (B) myotubes were transfected with 200 nM of myostatin AON and AON targeting different
To further assess its therapeutic potential, we performed dual exon skipping in the DL589.2 cells, which were derived from a DMD patient with an exon 51-55 deletion. Our previous study has shown that the reading frame can be corrected by an exon 50 skip upon transfection with h50AON1
Figure 5
Dual exon skipping of myostatin and dystrophin in DL589.2 DMD patient cells
Dual exon skipping of myostatin and dystrophin in DL589.2 DMD patient cells. DL589.2 myotubes were transfected with 200 nM of myostatin AON and h50AON1 DMD AON. RNA was isolated two days post-transfection and analyzed for myostatin and dystrophin skips by RT-PCR.
Myostatin exon skipping
We subsequently examined the ability of myostatin AON to induce exon skipping in the
Figure 6
Administration of myostatin AON in
Administration of myostatin AON in
Our previous study in dystrophin exon skipping had indicated that higher skipping efficiencies could be obtained by multiple injections of the AON. In order to increase the efficiency of the myostatin AON and to answer whether dual skipping can be achieved
DMD patients suffer from progressive muscle wasting due to the absence of functional dystrophin protein. The AON-mediated exon skipping therapy has been shown to successfully reframe the mutated
Our results show that the second exon of the
The effects of interventions with myostatin expression in muscle differentiation were assessed by increased expressions of
Finally, the mix of myostatin and dystrophin AONs showed that skipping two genes is feasible without interfering each other. The experimental set up was varied by mixing the AONs before complexing with the transfection reagent, or by preparing complex of AON and transfection reagent separately before mixing with each other to rule out the possibility that two AONs hybridize to each other. There seems to be no difference in the skipping efficiency, regardless if both AON were pre-mixed or not. However, we recommend to check the hybridization-likelihood by verifying the sequences of both AONs using freely available software tools such as RNAstructure
One less encouraging finding was considerably low
In conclusion, our results provide a rationale for the use of two AONs targeting two different genes and further extend the versatility of exon skipping-based therapy. The efficiency and delivery techniques remain to be improved, especially for further
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
DUK performed experiments and wrote the manuscript, WMH participated in study design and performed experiments, SHvH and ST performed experiments, DjdG, JTdD, GJBvO, AAR and PtD participated in study design, PAtH conceived and coordinated the study. All authors read and approved the final manuscript.
We would like to thank Dr. Michael Antoniou (King's College London) and Dr. Jennifer E. Morgan (Dubowitz Neuromuscular Centre, University College of London) for providing myoblasts used in this study. This work was funded by the Dutch Duchenne Parent Projects (to PACtH) and Centre for Biomedical Genetics (to PtD and GJvO).
An explanation for the phenotypic differences between patients bearing partial deletions of the DMD locus
Entries in the Leiden Duchenne muscular dystrophy mutation database: an overview of mutation types and paradoxical cases that confirm the reading-frame rule
Diagnosis and new treatments in muscular dystrophies
Gene therapy for muscular dystrophy: current progress and future prospects
The therapeutic potential of antisense-mediated exon skipping
Targeted exon skipping as a potential gene correction therapy for Duchenne muscular dystrophy
Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients
Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense
Improved antisense oligonucleotide induced exon skipping in the mdx mouse model of muscular dystrophy
Targeted exon skipping in transgenic hDMD mice: A model for direct preclinical screening of human-specific antisense oligonucleotides
In vivo comparison of 2'-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping
Local Dystrophin Restoration with Antisense Oligonucleotide PRO051
Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study
Cell heterogeneity upon myogenic differentiation: down-regulation of MyoD and Myf-5 generates 'reserve cells'
Myogenic satellite cells: physiology to molecular biology
Evidence for defective myoblasts in Duchenne muscular dystrophy
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
Double muscling in cattle due to mutations in the myostatin gene
Myostatin mutation associated with gross muscle hypertrophy in a child
Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis
Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
Myostatin signals through Pax7 to regulate satellite cell self-renewal
Myostatin Regulates Cell Survival during C2C12 Myogenesis
Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells
Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation
Functional improvement of dystrophic muscle by myostatin blockade
Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO-029
A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy
Myostatin propeptide-mediated amelioration of dystrophic pathophysiology
Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice
Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice
Coordinated patterns of gene expression for adult muscle build-up in transgenic mice expressing myostatin propeptide
Regulation of muscle growth by multiple ligands signaling through activin type II receptors
Myostatin directly regulates skeletal muscle fibrosis
Combination of Myostatin Pathway Interference and Dystrophin Rescue Enhances Tetanic and Specific Force in Dystrophic mdx Mice
AAV-directed muscular dystrophy gene therapy
RNA-targeting approaches for neuromuscular diseases
Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice
Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies
Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms
Myostatin imposes reversible quiescence on embryonic muscle precursors
Myostatin negatively regulates satellite cell activation and self-renewal
Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites
RNA secondary structure prediction
Antisense-induced Myostatin Exon Skipping Leads to Muscle Hypertrophy in Mice Following Octa guanidine Morpholino Oligomer Treatment
Quadrupling Muscle Mass in Mice by Targeting TGF-β Signaling Pathways
Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators
Pre-publication history
The pre-publication history for this paper can be accessed here:


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The international war-crimes tribunal in The Hague yesterday charged a Bosnian Serb general with crimes against humanity for abetting the siege of Sarajevo, which killed more than 10,000 people and wounded 50,000.
Hours after the Bosnian government declared that the blockade was over- in practice it ended in December after the arrival of Nato troops - the UN tribunal indicted Lieutenant-General Djordje Djukic, a Yugoslav Army officer who ran the Bosnian Serbs' logistics operations.
The general was indicted for aiding and abetting the siege in which "Bosnian Serb military forces, on a widespread and systematic basis, deliberately or indiscriminately fired on civilian targets that were of no military significance in order to kill, injure, terrorise and demoralise the civilian population".
The general's lawyer, Milan Vujin, was contemptuous: "This contains one fact: that General Djukic is in the Bosnian Serb army," he said. "If that is all they have, we can get the trial over today. Yes, he's in the Bosnian Serb army. There's not one other fact here."
General Djukic fell into the hands of his alleged victims on 30 January, when his driver took a wrong turn into Sarajevo and was stopped by Bosnian police. They arrested General Djukic and Colonel Aleksa Krsmanovic, a colleague, prompting an angry response from Bosnian Serb leaders in Pale, who severed ties with the Nato peace force (I-For).
Two weeks later, General Djukic and Colonel Krsmanovic were dispatched on a Nato plane to The Hague for investigation, to the rage - and fear - of their military and political masters. Both men refused to co-operate with the tribunal as witnesses; the Chief Prosecutor's response was to indict General Djukic and extend the colonel's detention.
"Being unable to continue to regard General Djukic as a witness we have had the opportunity of considering evidence we have against him," Judge Richard Goldstone said yesterday. "Whilst our investigations ... are not yet complete, we considered that in respect of two counts there is sufficient evidence to justify indicting General Djukic."
Judge Goldstone said the indictment was likely to be amended as investigations continued. General Djukic was already known to the tribunal: his name figured in evidence attached to the earlier indictments on war crimes of Radovan Karadzic and General Ratko Mladic, the political and military leaders of the Bosnian Serb forces.
Most Bosnian Serbs were angered by the arrest of General Djukic, arguing that he and Colonel Krsmanovic were "backroom boys" who could not have blood on their hands.
But both had an important role in organising the weapons and ammunition for the siege, which ended formally yesterday when Bosnian police took control of the Serb-held suburb of Ilijas, linking the city to government territory for the first time since May 1992.
Both men could bring down bigger prey, perhaps even President Slobodan Milosevic of Serbia. Despite the routine denials from Belgrade, it is clear Serbia's help was crucial to the war effort of its Bosnian clients. General Djukic is an officer in both the Yugoslav and Bosnian Serb armies.
General Djukic, due in court on Monday to enter a plea, is unlikely to face trial for months. The only other suspect in detention, Dusan Tadic, is expected to stand trial on 7 May, more than a year after his extradition from Germany to The Hague. Both he and General Djukic are housed in a specially built cell-block in Scheveningen prison.
Colonel Krsmanovic will be another neighbour for at least a month, held as a possible suspect and witness. Judge Goldstone is considering whether to indict him or release him to the Bosnian authorities, who would pursue their own case against him. The colonel refused to attend earlier hearings because he does not recognise the tribunal. He may now consider the role of turncoat preferable to that of defendant.
- More about:
- Sarajevo
- Serbia
- The Hague
- War Criminals


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by W. Owen ColeOne of the world's major faiths with more than 20 million adherents, Sikhism is a religion which most people, including academics, seem to ignore. This introduction assumes no prior knowledge on the part of the reader. At the centre of the religion is the scripture, the Guru Granth Sahib, it is the focus of Sikh theology and practice to the extent that no one is allowed to come between it and the
The Weather Man: A Spiritual Journey Through the SeasonsThe Weather Man' is a spiritual journey through the seasons and uses the variabilty of the English climate as a recurring theme in the quest for enlightenment. Many of our existential problems in both spiritual and material terms are either resolved or transcended in this unusual and beautiful story of nature and our place in the world.
Sikhism: A Very Short IntroductionVery Short Introductions The Sikh religion has a following of over 20 million people worldwide and is one of the largest religions in the world. However, events such as the verbal and physical attacks on Sikhs just after September 11 indicated that Sikhs were being mistaken for Muslims, and suggests that the raising of sufficient and appropriate awareness about Sikhism still needs to be addressed. This book will introduce
Between Colonialism and Diaspora
Sikh Cultural Formations in an Imperial WorldBringing South Asian and British imperial history together with recent scholarship on transnationalism and postcolonialism, Tony Ballantyne offers a bold reevaluation of constructions of Sikh identity from the late eighteenth century through the early twenty-first. Ballantyne considers Sikh communities and experiences in Punjab, the rest of South Asia, the United Kingdom, and other parts of the
by CollectifDans la perspective du prochain synode africain, des religieux et religieuses de la famille de l'Assomption, issus de quatre continents, s'interrogent sur l'avenir du christianisme en Afrique. Leurs analyses croisent l'anthropologie, l'histoire, la théologie. Soucieux de promouvoir un dialogue entre la foi et la vie, ils ont voulu communiquer les résultats de leur recherche.
Buddhists, Hindus and Sikhs in America
by Gurinder Singh Mann and 2 moreBuddhists, Hindus, and Sikhs in America explores the challenges that Asian immigrants face when their religion--and consequently culture--is "remade in the U.S.A." Peppered with stories of individual people and how they actually live their religion, this informative book gives an overview of each religion's beliefs, a short history of immigration--and discrimination--for each group, and how
$14.99Five hundred years ago, Guru Nanak founded the Sikh faith in India. The Sikhs defied the caste system; rejected the authority of Hindu priests; forbade magic and idolatry; and promoted the equality of men and women -- beliefs that incurred the wrath of both Hindus and Muslims. In the centuries that followed, three of Nanak's nine successors met violent ends, and his people continued to battle
South Asian Religions on Display
Religious Processions in South Asia and in the DiasporaReligious procession is a significant dimension of religion in South Asia. Processions are central not only in Hinduism, but also Islam, Christianity, Jainism and Sikhism, which have large procession rituals. The last years have seen an increase in processions and ritualizations of space both in South Asia and in the South Asian Diaspora. Processions are religious display events and the increase
Historia, identidad y religionFilled with the rigorous detail of a historian, this dynamic history of the Sikhs covers their origins in the 16th century, the expansion and transformation of the community, the establishment of a military order, the reformist movement of the 19th century, how Sikhism has separated itself from Hinduism and Islam as well as contemporary issues. Analyzing the essential traits of the Sikh doctrine
The Life and Times of Maharaja Ranjit Singh
by Patwant Singh and 1 moreRanjit Singh has been largely written out of accounts of India's past by British historians, yet he was one of the most powerful and charismatic figures in Indian history. He unified the warring chiefdoms of the Punjab into an extraordinary northern empire, built up a formidable army, kept the British in check to the south of his realm, and closed the Khyber Pass through which plunderers had
$8.69Simple Guides THIS BOOK WILL HELP YOU• to appreciate one of the historic religions of the Indian subcontinent• to understand what it means to be a Sikh, especially the guru—disciple relationship• to recognize the key festivals of the Sikh year and the different aspects of Sikh worship and practice• to avoid faux pas in conversation, in travelling and in personal relationshipsACCESS THE WORLD'S RELIGIONSSimple


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My friend and his girlfriend went to Disneyland on Tuesday. He was complaining to me about the computers being down, and a hour wait and could not by the combo pass for both parks. He went to Customer Service and complained and got a free ticket for each for the other park. I questioned him on the day and it must have been the Zotob as I heard Disney and ABC (Parent company of Disney) were hit by it along with others like CNN.
Monthly Archives: August 2005
MSN adds a 3 day forecast add-on to the MSN Search Toolbar
"Your three-day weather forecast is only a click away with the new Weather Add-in. Check the temperature, expected highs and lows for the location of your choice, and more."
You may also download the informative MSN Screen Saver beta
Microsoft Windows 2000 Users Patch FAST!
New worm will cause you machine to infest others and reboot and repeat. It will not damage your data, but your PC will be unusable till it is fixed. The fix for this worm is not for novices.
Please go to http://windowsupdate.microsoft.com or the new site http://update.microsoft.com and get all the critical updates. I highly suggest that everyone no matter which version of Windows, to get the latest critical updates when they come out to prevent something like this. Also, you can turn on Automatic Update to alert you to new updates, or download then alert, or download, alert and auto-install.
CNN Got hit, and also you can see some of the inaccuracies. There are links here to the actual article about the patch at Microsoft. http://www.neowin.net/comments.php?id=29981&category=main
Also, Anti-Virus software can catch them most times. So please get one. There are some free ones listed here. I have heard good things about AVG one, which is on version 7 and this page needs updating in regards to the features and version numbers. http://www.computertalkshop.com/faq/free_av.htm Make sure auto-updating is enabled. AVG usually releases updates daily.
Microsoft jazzes up MSN Spaces blogging service
Microsoft jazzes up MSN Spaces blogging service.
New features called 'PowerToys' unveiled in Microsoft official's blog
Massive spyware-based identity theft ring uncovered
Spyware can be used to harvest info to steal your ID or steal from you:
New MSN Messenger, Spaces, Mail Demoed
Read about some cool changes to MSN Messenger, Spaces and Mail.


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Beckett Fountain Pump for Indoor / Outdoor
|The Beckett Fountain Pump is excellent for use with both indoor and outdoor fountains. Its rotary valve allows you to control the flow adjustment easily, while its rotating outlet pipe provides a convenient connection for compatible ID tubing. Water Pumps can be used indoor / outdoor Pump has an adjustable flow control valve with a 6' power cord 1 Year manufacturer warranty Beckett's Pond & Fountain Pumps come in 4 sizes. All pumps are not oil filled, are wet rotor-electrically efficient, and equipped with easy-to-adjust flow control. M60 - For small/tabletop fountains & Pond Art™ - 7061010- 60 GPH @ 1' lift- Requires 1/4" or 1/2" I.D. tubing M130 - For small/medium fountains - 7091510- 130 GPH @ 1' lift- Requires 1/2" I.D. tubing for connection M280 - For small/medium fountains - 7061210- 257 GPH @ 1' lift- Requires 5/8" I.D. tubing for connection M400 - For large fountains - 7061310- 405 GPH @ 1' lift- Requires 5/8" I.D. tubing for connection
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Erickson's narration has the strikingly confident acting chops of a charismatic lead actor in a great long-running television series. She knows and inhabits her cast of characters decisively, while carefully mining the little diamonds of growth and change that Robb seeds into these stories.
From Dallas' driven, prickly authority, to Roarke's potent charm, to Peabody's nerdy earnestness, and the handful of unique, well-drawn secondary characters, the cast here is entertainingly diverse but hasn't grown too large for listeners to catch on quickly to who's who. And kudos to Ericksen for making it easy by capturing each voice clearly, and using finely tuned pace and timing to bring out all the wit, blood-chilling suspense, and sizzling romance in Robb's storytelling.
Great villains are also a trademark of this series. The bad guy here is a master manipulator, a chameleon who slips and slides through the city, killing with a cruelty that shakes Dallas to her core. Ericksen gives him a guileless menace that rings terrifyingly true. Watch for a terrific 90 degree twist near the end that provides that perfect combination of thrill and 'a-ha!' to round out this plot.
Robb's In Death series is, like all the great police procedurals, built on rich character development. Dallas is sexy, acerbic, absolutely tenacious, and destined to rub people the wrong way. Roarke is drop-dead gorgeous, filthy rich, and utterly in love with his wife. This is partnership as the ultimate romantic relationship, and a crime-fighting team that's unstoppable.
In July 2009 The New Yorker magazine featured a long overdue profile of the immensely successful Nora Roberts (a.k.a. J. D. Robb). So if you're a first-time listener coming to see what all the fuss is about, the In Death series is about to become your favorite new way to kick back and enjoy a great story well told. Nancy Carter
Not even their worst nightmares could have prepared them for the crime scene that awaits them inside. Deena has been brutally murdered in her bedroom, and her body shows signs of trauma that horrify even the toughest of cops, including our own Lieutenant Eve Dallas, who is specifically requested by the captain to investigate.
The evidence piles up, and Dallas and her team think they are about to arrest the perpetrator. But little do they know that someone has gone to great lengths to tease and taunt them, using a variety of identities.
Overconfidence can lead to careless mistakes, but for Dallas, one mistake might be all she needs to bring the killer to justice.
©2009 J.D. Robb; (P)2009 Brilliance Audio, Inc.
"Kindred In Death"
Nora Roberts is one of my favorite authors. I have read all of the J.D. Robb series and they are wonderful reading. The characters are dynamic and the stories move with clarity. Dolores
"Another good one"
I have all of these books and love them every one. The main family of characters are great and I feel that I am a part of their lives. I would love to have the ability to be able to create a world all on its own. JD Robb/Nora Roberts always make me feel the emotions of the characters. The twist of the plot is always there and surprising. Ready for more.
Love books, preferably romance and suspense. Typically read/listen to 3-5 a week.
"Another great book"
I love the Eve Dallas Series. The person that wrote the other review must not be a fan of the series. I could listen to a book on the Death Series once a week. I couldn't wait for this book to come out. I was upset it took so long. Once I caught up and listened or read them all I was lost waiting for another book. I must admit either you like the Death series or you don't. I think some people think it should be more futuristic or sci-fi; it is very balance and very entertaining. I have thoroughly enjoyed each book. This book did not disappoint me. I enjoyed every minute. I am impatiently waiting for Missing in Death later this month and hope she has two more to come out in December.
"Good Story"
Good listen - consistent JD Robb - no surprises there. Well Narrated and enjoyable.
"Great book"
Another winner by J D Robb aka Nora Roberts.
Narrator did an awesome job
"Love this series!"
Can't get enough of this series! Love the characters, the stories and listening to Susan Ericksen. Can't wait for the next one to be released.
"worst of the series"
I like this series. I am not a Nora Roberts fan, or a fan of romance novels in general, but the repartee between the characters in this J.D. Robb series has hooked me somehow. That kind of interplay is, well, not absent, but too rare in this novel; there is some redundancy in the discovery of clues (where was the editor?); and the whole is just lackluster. OK for $10, but I'm glad I didn't pay fulll price.
"Goes really far from the original story."
No I would not recommend this book it just gets you confused to what murder your solving.
First book I have got lost in. Jumbled.
She is good.
Take a nap.
great listen! this whole series is awesome! I love how many hours of listening these books provide!
"Eve always gets it done."
It's hard for me to believe that someone can have so many voices for all the characters in these books. There are a few that are hard to listen to but they make the character and you know who is who.these books have been going on from 1995 and she always keeps them the same, amazing.
Yes , the death scene was so vivid and got me so evolved that I wanted the perp to get the same treatment.
It's great that the setup sometimes doesn't work. I am amazed at how anyone can come up with so many characters and plots.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


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Iran, a key Opec producer, yesterday gave guarded support to a call from Saudi Arabia for an extra 1.5m barrels a day.
Opec will meet this week to discuss the situation after the cost of crude leapt to $41.50 a barrel in New York on Friday.
Fears are mounting that the oil price, now at a 21-year high, will destabilise world economic growth.
Oil prices have spiralled upwards because of tight supply and fears about security in Iraq and elsewhere. At the same time, demand from China and the US has proved stronger than expected.
Separately, it emerged that Iraq is to recreate a national oil company before the US hands power to a new Iraqi government on 30 June.
- More about:
- Energy
- Fossil Fuel
- Iraq


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SICO South Pacific Ltd
Global manufacturer SICO has designed, manufactured and delivered superior furniture to the hospitality, leisure, education and government industries for over 60 years. Established in 1951 SICO has grown to include offices and factories in Ameria, Asia, Europe and Australia. These local offices service customers throughout the world with SICO highest quality portable dance floors, staging, tables and many other space saving products.
SICO South Pacific was one of the founding companies to establish the portable staging, dance floor and mobile table market for Australia and New Zealand. They have a wide range of products and a dedicated team of customer service professionals.Learn more


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Fun at the Fair
- 17 Comments
Looks like fun! And those matching outfits, soooo cute!ReplyDelete
I'm impressed Caroline went on the rides by herself, such a big girl! Also, now I want some fried pickles! Not always easy to find!ReplyDelete
Could your family be any cuter?!? Caroline looks so grown up in these pics! And the matching outfits....darling! My sis and I matched all the time growing up! They will love having each other!! :)ReplyDelete
Love your fair pictures! We took Piper this year and the girl fell in love with the "ponies" aka the carousel.ReplyDelete
Looks like a blast...love the girls matching outfits!! XOReplyDelete
In love with the matching outfits! Love the family pictures!ReplyDelete
What a fun recap! Sounds like you had a wonderful time and what sweet memories for your little girls. :)ReplyDelete
I LOVE fair time in our area! The girls look adorable :)ReplyDelete
so fun! I love your sweet girls in their matching outfits!ReplyDelete
They're both so precious!ReplyDelete
I just randomly stumbled across your blog, love it, new follower! Our blog names are similar, great minds think alike ;) Your family is precious and you look fab Momma!ReplyDelete
Instagram: megawat
beautiful photos,visiting for 5 for friday.ReplyDelete
new GFC follower
hope you can visit my Five for Friday
Looks like a blast!! CC looked so cute in the video at the fair you posted on Instagram.ReplyDelete
Seriously, could CC be any cuter! Love her cheesing it up in the ride! We need to hit a fair, Mac would love that! Carson looks so unimpressed. :) And I just love their little matching outfits!ReplyDelete
CC is ADORABLE. I can't even handle it. :)ReplyDelete
Caroline is so cute! I love the pictures of her on the rides. What a big girl!!ReplyDelete
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2017 BEST PRACTICEs CONFERENCES SERIES - BOOK YOUR PLACE TODAY!Other Events
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News : Erste Bank and Sparkassen Introduce Contactless Payments
Vienna, Austria, June 10, 2016 -- Erste Bank und Sparkassen are making contactless payments possible without a traditional bank card or a smartphone. With the NFC wristband developed by the Sparkassen Group or the NFC-capable sticker, it is possible to pay via a Maestro transaction directly from one's bank account.
PIN codes and limits are the same for both products as for one's existing bank card and one can use them for payments worldwide. The same rules for payment sizes apply as well: no code is needed for payments of less than EUR 25, otherwise a PIN code has to be entered. The same security criteria that apply to traditional bank cards, also apply to these solutions.
Wristband and sticker can be purchased with immediate effect at George or with the CardControl App. The new NFC products can also be ordered at branch offices. They are sent through the postal service and have to be activated prior to first use, either online or via telephone at the Erste call centre. Both products are available Austria-wide exclusively at Erste Bank und Sparkassen.
Every third bank cash register in Austria is already NFC-capable, and by 2020 all terminals will also be equipped with this function. In future, cash machines themselves will be NFC-capable as well. Erste Bank has put the first functional NFC ATM into service at the Erste Campus in Vienna. This ATM can be used to for contactless withdrawals, but it always requires entering one's PIN code.
A mobile app for paying with one's smartphone is available from the Sparkassen Group as well. This requires an NFC-capable smartphone with Android software and an existing contract with A1, Drei, or T-Mobile. For this purpose one has to order an NFC-capable SIM card from one's service provider and order BankCardMobil via George or CardControl.
Posted by Veronica Silva Cusi, news correspondent
Source: http://www.telecompaper.com
Today's Tip of the Day - Simplicity, Simplicity, Simplicity!
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Published: Monday, June 13, 2016
Industry Champion Award Leaderboard
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PSH Consult
Navigate the Transition to Value-Based Perioperative Care Successfully
NEW- Customized education, assessment and resources for your practice
The PSH Consult assesses your organization's strengths and opportunities for further development in the context of your PSH initiatives, whether they are currently under development or already underway.
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Helpful resources to educate your PSH team and C-Suite about the PSH Consult. The tool kit includes FAQs, presentations, talking points and an overview flyer.
Accreditation and Designation Statements
The American Society of Anesthesiologists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The American Society of Anesthesiologists designates this activity for a maximum of 5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.