text:
WASHINGTON (Reuters) – The Environmental Protection Agency (EPA) is expected to propose on Wednesday more stringent air quality standards for ground-level ozone, the main culprit in smog, sources said.
Under a court-ordered deadline of next Monday to release its proposal, the agency could propose a National Ambient Air Quality Standard between 65 and 70 parts per billion concentration of ozone, and take comment on standards within a 60-75 ppb range, sources familiar with the matter said.
That would compare with the current level of 75 ppb set under then-President George W Bush in 2008 The EPA would have to finalise the rule by October 2015. The agency declined to comment
The proposal, which will apply not only to power plants but to cars and oil and gas facilities, is expected to face opposition from industry groups.
The tougher standards would be closer to the proposal drafted in 2011 by former EPA Administrator Lisa Jackson, which was withdrawn by President Barack Obama before its releasebecause of concerns about regulatory costs during a time of economic recovery.
Although Obama had directed the EPA to come up with a new proposal, the agency did not take action, prompting the American Lung Association and green groups Earthjustice, the Sierra Club, the Environmental Defence Fund and the Natural Resources Defense Council to sue and get a court-ordered deadline.
Health and environment groups say the new standards can lower the risk of early deaths, asthma and other respiratory illnesses from the pollutant.
"President Obama is not up for re-election. This should be a centerpiece of his environmental legacy," said Terry Maguire, the Sierra Club's Washington representative on smog pollution.
He said the coalition of green and health groups had been pressing for a standard of 60 ppb, but added he could support a range of 60-70 ppb, which EPA scientists have recommended.


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About me:
Activities: Being Lazy.
Interests Being Lazy, listening to music, web surfing.
Favorite music: Oldie stuffs, Stones, Beatles, The Who, and of course Queen! and other artists. :D
Favorite movies:I
Favorite TV shows: Monty Python, I love Lucy, MST3K, etc.
Favorite books:
Favorite quotes:
Favorite band member:Freddie Mercury
Favorite Album:
Queen fan since:Few Months ago
I became a Queen fan because:Well I knew about them for a long time and something just triggered and I fell In Love with them.
My favorite Queen item I own:all of it ;)

subset: commoncrawl


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"My experience at Lake Superior State University is one of the best of my life. Not only did the education I received prepare me immensely for the work world, I made friendships and connections that are sure to last me a lifetime. LSSU is the perfect collegiate experience: exceptional educators, a welcoming community and the beauty of Michigan's Upper Peninsula."
--Chelsea Sparrow
LSSU Athletic Training Graduate;
ATC Graduate Intern Athletic Trainer;
University of Minnesota, Duluth
« prev · photos home· next
Student Alumni Involved for Lake State (SAILS) kicked off Great Lake State Week celebrations for students with Laker breakfast Monday morning. Fifty dozen donuts purchased from a local bakery were given away to students on their way to 8 and 9 a.m. classes. Nic Harrington of Union, Mich., shows off a flat of donuts destined for early-rising students.


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Villa in Benalmadena Pueblo, Benalmadena, Costa del Sol, Spain - Peaceful and Tranquil and Walk to the Village in 15 Minutes
The villa is ideal for families, it is spacious and well furnished. The master room is very large. It has wifi free of charge and TV. There are two outdoor eating areas, It has a stunning view from the roof terrace with a built in BBQ, fridge and seating for great al fresco dining. There is also another terrace with dining facilities off of the lounge/dining room. There is a garden for there kids to play and a large communal pool.
Top Traveller Review
super villa
About the Owner
About Jane Dennis
Once the family home, now for holiday rentals so enjoy as we have
Why Jane Dennis chose Benalmadena
The location is great, the house works, with its layout and size. The community is secure and friendly. You are minutes from the village but can feel in a world of your own when in the house.
What makes this villa unique
It has good memories shared by lots of people.
1 Reviews
5/5 -
(1 traveller reviews)
super villa
would highly recommend a stay at this lovely accommodation. Located within a secure gated complex the villa and grounds are very well maintained. we travelled with a 3 month old baby in our party and were apprehensive about what we would find but were reassured upon arrival. Everything was very clean and the whole house is very spacious. We were met on arrival and assured that help was on hand if needed (Although it wasn't). The beautiful Benalmadina Pueblo Village is located nearby. A great shared swimming pool on site .Thanks to Jane and Sage . We hope to re-book for next year.
From the Owner
"The location is great, the house works, with its layout and size. The community is secure and friendly. You are minutes from the village but can feel in a world of your own when in the house."
Activity and Interests
The villa is 5 minutes in the car to the beach
Málaga is the nearest airport and is approximately 20 minutes away. Flights do also go to Gibraltar which is about 1 1/4 hours away
Benalmadena Pueblo is 2 minutes away in the car, Arroyo de la Miel is about 7 minutes, Tivoli World 5 minutes.
The nearest train station is Arroyo de la Miel and that is 5 minutes away.
Further Details:
The village is full of character and has bars, restaurants and shops and banks. Some of the streets are lined with orange trees. There is a Butterfly Park, the Buddhist Temple, a castle, the local church all great things to see in the village.
Prices and Availability
Rental rates
- Booking Notes:
To book you need to pay 30% deposit and the balance 6 weeks before your arrival. A security deposit will be held and returned to you within 14 days of your departure. This will be paid with the final balance.
Changeover Day:
We are flexible with changeover days
Notes on prices:
Longer stays over 3 weeks can be taken and prices negotiated accordingly
Winter Let Considered.
The air con is metered and takes 1€ coins. We give you a 5€ starter pack
- 12
- Available
- 12
- Unavailable
From the Owner
"It has good memories shared by lots of people."
Property Type
- villa
- Air Conditioning
- Internet
- Iron & Board
- Living Room ...
- Parking
- Washing Machine
- Dishwasher
- Freezer
- Kitchen ...
- Microwave
- Oven
- Refrigerator
- Hob
- Television
Pool / Spa
- Communal Pool
Location Type
- beach
- village
- Bathroom 1 - Toilet, Bath (no shower), Shower Enclosure
- Shower room 1 - Shower Enclosure
- Shower room 2 - Shower Enclosure
- En-suite Master bathroom with shower Second bathroom with large walk in power shower Family bathroom with bath Guest toilet
- 4 Bedrooms, Sleeps 9
- Bedroom 1
- Bedroom 2
- Bedroom 3
- Bedroom 4
- Description of sleeping capacity: Sleeps 9 (4 Bedrooms) Notes on bedrooms: Bedroom 1 very large master/family room en-suite with king bed with new memory foam mattress and single bed, also space for a cot, patio door leading to garden Bedroom 2 King bed en-suite Bedrooms 3 and 4 with twin beds, patio doors leading to garden
- Golf ...
- Garden
- Ski & Snowboard ...
House Rules
- Max. occupancy: 9
- children welcome
- Notes on accommodation: This house is a great family house. You drive into the urbanization which is gated. The house is an upside down house so you see it from the front and it looks like a one storey house, you walk into the hallway and you have your kitchen to the left, the hallway then has a guest toilet, entrance to the second en-suite bedroom and continues to the lounge/dining room. Also there is a staircase that takes you to the large roof terrace with built in BBQ. There is a terrace off of the lounge with dining table and chairs, there is an outdoor staircase from the terrace down to the garden. The dining area inside has a beautiful regal formal dining table. Downstairs there are 3 bedrooms, the master with en-suite is very large and can also be classed as the family room as it has a full single bed available. The utility room with washing machine and access from the downstairs hallway to the garden. 2 Twin rooms have access to the garden through patio doors and there is a family bathroom. Outside: BBQ terrace with built in fridge, dining table and seating for 8. Great for sunbathing as it has sun all day. The terrace from the lounge also has dining table and seating. The garden has a lemon tree and olive trees. The pool is communal and is accessed by the steps outside of the villa. It is a very large pool and great for kids to play and adults to sunbathe. Utility Room: Washing machine Cleaning / Towels / Linen / Maid service: Villa is cleaned and ready for your arrival, there is one bath towel and one hand towel per person. If you stay for 2 weeks the villa has an interim mid stay change of laundry and towels. Please bring your own pool towels. Other: Roof terrace with stunning views, built in BBQ and seating for alfresco dining


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A family home: convenient, comfy, and designed for the whole family
You will love being so close to our nearby amenities; supermarkets, take away places, a fantastic library, 2nd hand stores, clothing shops, etc.
Our home is in a quiet suburb, yet just a couple of minutes drive from the highway that takes you to all the main local tourist attractions in 15 minutes, including galleries, theatre, cinemas, the steepest street in the world (literally!), the beach, etc.
You will find it so convenient that our home is just a 15 minute drive from the main airport of Dunedin!
To organize a home exchange, you need to be a member


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is noncompulsory but will seriously enhance your chances of having members look at your profile. Let people know a bit about yourself, your hobbies and upload some good photos of yourself.
Utilise our website's cutting-edge search to find members who match your desired criteria. Or just browse through listings and find singles that appeal to you.
Found someone who you like the look of? Drop them a line or just a wink and see if anything develops. With a little luck you'll be on your way to locating the love of your life.
And start dating


text:
Tending to Mathew
Sarah enjoyed the warmth of Jason's embrace. Though they had never been able to touch in The Grove, there was a comforting familiarity to it. All too soon he pulled away and turned from her. He pulled the dagger out of the wall and proffered it to her hilt first. Sarah looked at him puzzled.
"Normally, the Nigiri blade goes to the surviving family as a reminder of the victim's defiance to the Gods; however as the only survivor of a Nigiri assassination, I think it is only proper for you to have it." He smiled, "A reminder that the Gods are on your side."
Sarah gingerly took the knife as her head began to pound. "The only survivor?" She remembered the Prince's disbelief in that fact. "So Nigiri assassinations don't fail?"
"Normally Nigiri targets are ordained by the Gods," Jason started.
But that was all Sarah heard. The pounding in her head quickly overrode everything. Her hands immediately went to her temples as she slowly sank to the ground. She barely noticed Jason stroking her hair. It seemed to take forever before the sound of his voice broke through.
"Sarah?" She looked up at him. "Sarah, are you well?"
"I'm fine," she said a bit more testily than she meant to.
Slowly her head returned to its normal state and Sarah stood. Jason helped her up, keeping one hand on her elbow. His face was contorted with concern.
"You should get some more rest."
"I'm sick of rest," Sarah sighed and leaned against the wall.
"If it comforts you, my mother has arrived and would like to meet you tomorrow." Jason sighed and leaned on the wall next to her. "Like as not she will take you to the capitol as soon as she meets you and..."
"WHY?" A drunken tortured voice startled the two of them.
Jason turned to look first, his instincts honed by years as a Scout. Sarah was only a second behind him. Someone stood beneath the willow tree. The figure leaned towards the trunk before collapsing in a heap at its base.
"Shouldn't we help him?" Sarah asked when Jason turned back to lean against the wall. She studied the man as she waited for Jason's response. There was something familiar about him.
"It is Mathew. He will be fine." Jason shrugged. "The Gods will care for him."
"Jay!" Sarah was shocked by his uncaring response.
"What?" He turned to face Sarah. "He is only drunk, that is all."
"And you're going to let him sleep it off, outside?" Sarah couldn't believe this.
"He is under a Willow. He will be fine."
"What the hell does a willow have to do with it?" She did not expect Jason to be so indifferent to Mathew.
"Well..." Jason began, but Sarah cut him off.
"Never mind," her head had begun to hurt again. "Why don't you want to help him? He's a member of your scout troop and a friend."
"First off, we are off duty. Secondly he is my bodyguard, not my friend. Certainly not a friend as you would think of one. And lastly he insulted your honor." Jason crossed his arms and leaned against the wall.
"Jay?" Sarah choked on laughter, "I can defend my own honor you know."
"You should not have to, not as a Lady."
"Jay," Sarah chuckled, causing him to look at her. "I'm not a Lady." Something in his eyes made her place a hand on his arm. "Not that I can't play the part, but please," Sarah's eyes begged him, "don't think of me as something I'm not."
Jason looked down a moment then back at her. "I cannot help it. It is the only way..." his hands floundered like his words.
Sarah caught them. "Okay, I'll play Lady now, as I played Scout then. Just," she looked into his eyes, "promise me that someday I can just be me."
Jason bowed and kissed her hands. "I promise, Sarah."
Before Sarah could respond they heard Mathew retching. "Can we go help him now?" Sarah asked.
"The Gods will care for him." Jason stated. "You should get some rest."
Sarah rolled her eyes. "And what if the Gods put us here to make sure he was cared for?" She placed her hands on her hips and watched him. Jason had clearly not thought about that possibility. "Why don't you go get a bucket of water and I'll get a cup and cloth." He nodded.
Mathew was very inebriated. Sarah doubted he'd even remember her and Jason tending to him. Jay insisted on letting him sleep under the willow.
"It is not uncommon," he told her as he led her back inside.
He said more, but the words were blurred by another headache. Damn, Sarah thought, they were getting annoying. She needed to figure out what triggered them. Sighing she closed her eyes to get what little sleep she could in the remainder of the night.


text:
Are you still under the spell of your lunch at L'Amandier? Then visit our Boutique!
Our Epicerie Fine deli shelves are packed with many of the ingredients used by Denis Fétisson in his dishes served at L'Amandier and La Place de Mougins.
Jams, honeys, olive oils, spices… all are outstanding products carefully selected by the Chef himself so that you can enjoy the authentic taste of Provencal cuisine in your own home.
The L'Art de la Table tableware section offers an extensive choice of superb DF monogrammed items.
Cutlery by Laguiole and Sauveterre, table linen and porcelain by Bernardaud... Why not take a little L'Amandier magic home with you?
Traditional homemade ice creams to take away.
Every day (except Wednesdays and Thursdays)


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Busy People Make Things Happen! Lazy People Do Not.
WOW….I'm sitting here in complete gratitude for all of the experiences I've had over the past few months meeting incredible people, learning a new (profitable) Skill-Set, and having my second part time (at night, because it is the only time I have lol!) $4-Figure month online with the Empower Network. The Sky is the LIMIT!
Its funny, I remember making the decision to learn the skill-set of internet marketing while I had zero time to invest and not a ton of capital to get started. You see I make a GOOD living and LOVE what I do. I however I am "time poor" trying to make a life for my family. I want to leave my family a legacy. I want to take care of my parents, who have done so much for me. I want to show my children what generosity and leadership is. I want them to see the leadership example in me. I want to help people have fun, make money and most importantly, make a difference.
What is YOUR "WHY"?
I just knew early on that if I wanted to get results in any area of my life I had to follow people making it happen, not a teacher or professor's teaching "theory" on how to run a successful business. So I found the time (at night when most people are sleeping…whatever it takes right?) to make it work.
I remember telling people I would be retired (from worrying about money) by 40 and making enough money to provide for my family and help the people I love. Most people thought I was crazy (including my family lol).
But I can relate to why they thought I was crazy, because most people…..Don't Know, what they Don't Know. Think about that. Most people think they know about something…but have NEVER DONE WHAT THEY SAY THEY KNOW.
The truth is, if you have a burning desire to succeed, ANYTHING is possible. Its time to do what you love and live a Lifestyle by design 😀
(Below are a few screenshots of some of the commissions I was able to earn in just a few weeks in 2013)
I want you to watch the same video I watched that flipped my entire world upside down. This video is the reason why I got into affiliate marketing, it allowed me to see what's possible when I really had no idea.
Watch this video. (the video could take a couple seconds to load)
Nate $mith
#Project A.W.O.L
P.S. Click here to get started and work with me directly for only $25/month.
I look forward to helping you transition to an A.W.O.L. lifestyle, living more, loving more and living "another way of life. " –A.W.O.L.


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Tomato, Mexico Midget
- Organic
- Winner of SSE's 2014 Tomato Tasting
- Dark red fruits grow to ½-¾ inch
- Bursting with tomato flavor
- Very productive
- Indeterminate - Fruit ripens throughout the season
- 60-70 days from transplant
Winner of SSE's 2014 Tomato Tasting. Hundreds of ½-¾" dark red cherry tomatoes on each plant. Huge tomato flavor for such small fruits. Great for salads or selling in pints. Plants produce throughout the entire growing season. Indeterminate, 60-70 days from transplant.
Learn to Grow it
You should start plants indoors 4-6 weeks before the last frost date for transplanting them into the garden. Plant them outdoors 2-4 weeks after your last expected frost.
Plant your seeds 1/4-1/2 in. deep in soil trays or pots. Transfer them to 3-4 in. pots when their true leaves appear. When transplanting, bury seedlings up the stems up to their leaves.
Make sure that your soil is well fertilized as this crop is a heavy feeder and takes a lot of nutrients from the soil. Consider adding compost to the soil the year before you plant.
These plants prefer warm weather and soil so they should be grown when temperatures are over 68 degrees F. You should avoid watering them from above as damp leaves may be susceptible to disease.


text:
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Human Renin Protein expressed in Human Cells - ABIN2003666
Imai, Miyazaki, Hirose, Hori, Hayashi, Kageyama, Ohkubo, Nakanishi, Murakami: Cloning and sequence analysis of cDNA for human renin precursor. in Proceedings of the National Academy of Sciences of the United States of America 1984
Show all 3 references for ABIN2003666
Mouse (Murine) Renin Protein expressed in Human Cells - ABIN2007609
Nguyen, Delarue, Burcklé, Bouzhir, Giller, Sraer: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. in The Journal of clinical investigation 2002
Show all 3 references for ABIN2007609
Human Renin Protein expressed in HEK-293 Cells - ABIN2181691
Adams, Beveridge, van der Weyden, Mangs, Leedman, Morris: HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. in The Journal of biological chemistry 2003
Results show negative regulation of HDAC1 (show HDAC1 Proteins) by a Cul3 (show CUL3 Proteins)-REN E3 ubiquitin ligase (show MUL1 Proteins) complex.
REN is upregulated by neurogenic signals (retinoic acid, EGF, and NGF) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN protein enhances caspase-3 (show CASP3 Proteins) activation and antagonizes the Shh (show SHH Proteins) pathway suggesting that this gene may represent a restraint of Shh (show SHH Proteins) signaling.
This study demonstrates the efficacy of aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism.
The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.
Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC (show FECH Proteins)) and 3 weeks for plasma renin activity (PRA (show S100A6 Proteins)).
Active renin was not significantly different between hypertensive patients with and without left ventricular hypertrophy.
The present study provides evidence that the rs1464816 polymorphism in REN is associated with CKD progression in ADPKD.
Plasma renin and Aldosterone to renin ratio but not aldosterone are independently associated with presence of carotid plaques in coronary artery disease patients.
concentrations of serum aldosterone, plasma direct renin, and plasma renin activity were measured after a night's rest and again after walking for two hours.
Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas.
Elevated levels of circulating (pro)renin were observed in pre-eclampsia patients
The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of renin in renal tissue; this observation is in good accordance with the results of the transcriptional assay.
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, prorenin
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal
, renin-like
, preprorenin
, Angiotensinogenase


text:
Theology and Philosophy
PhD Scholarships in Virtue, Reason and Justice
Two PhD scholarships are being offered as part of a research project lead by Professor Robert Audi (University of Notre Dame and ACU).
A start date around the middle of the year is envisaged.
The scholarships will run concurrently with the operation of the new Centre for Moral Philosophy and Applied Ethics in the Institute for Religion and Critical Inquiry. Projects within the Centre are aimed at uniting theoretical work – particularly on reasons and virtues – with applications to questions of the distribution of benefits and burdens within just and fair societies, and on questions of the treatment of the vulnerable, particularly in areas where agency and autonomy are undermined.
Applicants should provide evidence of:
- An Honours or research Master's degree in philosophy, with first class honours (or H1 equivalent).
- Academic excellence (including but not limited to academic awards or grants)
- Demonstrated ability to contribute skilfully to a team
- A high level of verbal and written English proficiency
- Prior research experience and publication of research findings are desirable
Study mode:
Full-time only
How to apply:
Please use the Postgraduate Scholarship Application Form. Applicants should also include a cover letter of not more than two pages providing evidence of:
- Academic excellence, including, but not limited to, academic awards or grants;
- Ability to contribute to a team;
- English language skills; and
- Previous research experience.
Scholarship Applications should be forwarded to:


text:
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|9th June 2005, 12:40 AM
diyAudio Member
Join Date: Mar 2005
Location: New York
Replacement Parts
I recently acquired 2 old Carvin FET 1000 Amplifiers for my PA on EBay. They were both defective I had to replace the OPS, as suggested by some board members I replaced the original 15D20 20N20 FET's with IRFP240 and IRFP9240 HEXFETs. I completed one installation and biased according to the manufactures spec, when I went to test it at full volume the OPS blew.
The original owner of this amp had the amplifier repaired and the he also replaced the parts with the IRFP series named above. I have to assume the same thing happened.
In any event I have a show on Saturday and I need to get this sucker working. I was wondering if the OPS might need to be rebiased as a result of the replacement parts, any thoughts?
|10th July 2005, 03:48 PM
diyAudio Moderator
Join Date: Sep 2004
Location: Boston, Massachusetts
Blog Entries: 6
You need to get the specifications for both the old power fets and the new ones. Vds for the new ones should be equal to or greater than the originals. Rds should be less than or equal to the old ones. Drain current rating continuous and pulsed (or look at SOA curves - some fets do have them) should be greater than or equal to the originals. Pd should be greater than or equal to the originals. Gate capacitance and transconductance should be comparable or loop compensation may need to be tweaked.
There are no ballast resistors in the sources of your output devices, hence equal current sharing is not assured. In this design you probably need to use matched fets and/or add a small (.1 ohm) resistor in series with each source connection.
Finally make sure that the thermal resistance of the package is no more than the originals and that you have low thermal resistance to the heatsink. (Use thermal grease with mica insulators or silpads with the lowest thermal resistance you can find.)
All of this presupposes that the design is stable into a speaker load and doesn't also oscillate at VHF. Fit 1K gate stopper resistors right at the gates of the power devices if you see high frequency oscillation. (use a scope.)
This design uses a transconductance amplifier output stage - loop gain is a function of the load impedance on the output. Not noted as a paragon of stability. I would cautiously suggest you add a zobel network right at the output of perhaps 10 ohms and 0.1uF to define the load impedance at high frequencies and thus the loop gain. Be very careful though doing this, as depending on where the dominant pole is located this might make it less stable not more. In such a case you would decrease the value of the 0.1uF until it was stable - both with speaker load and without. Caveat emptor - if you are not comfortable using a fast scope and doing some analysis of what you observe I wouldn't attempt this.
Also look at the minimum load impedance - are you below it?
Testing at full power is ill-advised until you know that the amplifier is rock stable and can actually safely operate at the required power levels with the new devices.
You can add reversed biased high current diodes across the rails to output to provide some protection against misbehaving inductive loads at high power levels as well. (Recommended for PA use!)
|11th July 2005, 01:52 PM
diyAudio Member
Join Date: Mar 2005
Location: New York
Thanks so much for your input. Very insightful. I discovered that the reason the OPS was so instable was because two traces from the drain to the OP rail were severed. As a result only one OP FET was conducting on the negative rail, hence when the amp was turned up if it fried the device causing the whole OPS to go with it. I have since replaced the OPS and hard wired the Drain to the OP rail. Unfortunately I am now having difficulty adjusting the bias. I really don't know if I want to spend more time with these units. I may keep them for parts. I was an interesting project however. Thanks again for your assistance.
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Armani Hemden Fine Armani Herren T Shirt - factory price 1067 [561466armani] - Shop Armani Shirts 1067 for men, more varieties of colors and textures. All these now are on sale,buy clothing from us and save big today! You will get surprise from the deal. Armani ropa New Arrival Armani Camisetas for Hombres for cheap 1233 [543213c] - Wider sleeves of Giorgio Armani T Shirts for men 1233 offer a more comfortable fit. Heat pressed logo,Soft,stretchcotton. Armani clothes will always impress the minds of fashion people. Buy cheap price and high quality shirts from our shop. small messenger bag with single adjustable strap, zip-top closure, and inside zip and mobile phone pockets. 24 x 21 cm.
beige/ebony GG plus with brown leather trim and light gold hardware.


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STM Image Gallery - L'Hexagone
Title : A Copper Perspective
Media : Copper (111)
Click HERE for an even higher resolution TIFF image!
Reminiscent of formal Japanese rock gardens, here we see ripples
surrounding features on the copper (111) surface. The artists'
fortunes took a major turn upward when they determined that the
ripples were due to "surface state electrons." These electrons are
free to roam about the surface but not to penetrate into the solid.
When one of these electrons encounters an obstacle like a step edge,
it is partially reflected. The ripples extending away from the step
edges and the various defects in the crystal surface are just the
standing waves that are created whenever a wave scatters off of
something. The standing waves are about 15 Angstroms (roughly 10
atomic diameters) from crest to crest. The amplitude is largest
adjacent to the step edge where it is about 0.04 Angstroms from crest
to trough.
[Crommie, Lutz & Eigler]
Title : Circles on Circles
Media : Unknown on Copper (111)
Click HERE for an even higher resolution TIFF image!
Sometimes Nature is the best artist and all we need to do is catch it
in the act. Here we see the result of imperfect sample preparation:
two point defects adorning the copper (111) surface. The point defects
(possibly impurity atoms) scatter the surface state electrons
resulting in circular standing wave patterns.
[Crommie,Lutz & Eigler]
Title : Oh Where, Oh Where Has My Xenon Gone? Oh Where, Oh Where Can He Be?
Media : Xenon on Nickel (110)
Click HERE for an even higher resolution TIFF image!
The artists were known to supplement their income with daytime jobs as
scientists and here we see their touch being applied to just such a
daytime endeavor. The issue was 'Where does xenon bind on a metal
surface?' (a burning issue if ever there was one). Here we see not
one, but two images overlayed directly on top of one another. The
rectangular array of the little magenta bumps are the tops of nickel
atoms from one image poking up through the other image (you can do
that with the computer). The images are of the same area of the nickel
surface, just with and without the xenon atom (the big light blue bump
in the center). Defects in the nickel surface are used to get precise
registration information so the two images can be correctly
overlayed. The computer was used to chop off the top of the xenon atom
in order to peer through to the image of the surface without the
xenon. When you look through the hole in the xenon atom you see a
nickel atom located directly beneath. Evidently, xenon binds to the
on-top site.
Title : Untitled
Media : Cesium & Iodine on Copper (111)
Click HERE for an even higher resolution TIFF image!
Here we see the artists' first use of color mapping. Color is
assigned to the surface not only by lights but by local curvature of
the surface. This helps to delineate the shape of the object (which,
for the curious, is a molecule that they assembled from 8 cesium and 8
iodine atoms).
[Hopkinson, Lutz & Eigler]
Title : Atomic Teeter-Totter
Media : Sodium & Iodine on Copper (111)
Click HERE for an even higher resolution TIFF image!
The big glob is actually a well ordered crystal of 12 sodium and 16
iodine atoms that was assembled by Hopkinson in an attempt to build
extended two dimensional structures. To his surprise and delight, the
atoms had a mind of their own and spontaneously deformed into a three
dimensional crystal. Hopkinson was pleased to discover that this had
to do with the absence of commensurability between his crystal and the
underlying copper lattice. Sliding the crystal over the surface caused
different pairs of sodium atoms to sequentially pop up to the second
layer and then pop down to the first layer -- a sort of teeter-totter
[Hopkinson, Lutz & Eigler]
Title : Response of a Superconductor to a 4f Magnetic Impurity
Media : Gadolinium on Niobium (110)
Click HERE for an even higher resolution TIFF image!
The upper image is a constant current topograph of three gadolinium atoms on a
niobium (110) surface. The gadolinium atoms are used in this experiment as a
magnetic impurity on top of the superconducting niboium sample. The lower
image is a simultaneously acquired map of the conductance ( dI/dV ) measured
at a D.C. bias just above the gap voltage of the niobium. The lower image
shows the spatial extent of the bound state excitation in the superconductor.
This excitation was found to fall off on a length scale that is much shorter
than the superconductor's coherence length. It shows that the response of a
superconductor to a magnetic impurity is dominated by this short range effect.


text:
Simply Organic, Adobo Seasoning, 4.41 oz (125 g)
Simply Organic, Adobo Seasoning, 4.41 oz (125 g)
- You earn loyalty credit for every order you place at iHerb!
- Loyalty credit is equal to 5% of the value of your order, excluding shipping charges.
- Your loyalty credit will be applied towards your next order as soon as your current order has shipped.
- Your loyalty credits are valid for up to 60 days from the date of your last purchase.
Expiration Date:?Jan 2020Expiration Date
The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:?0.49 kgSwitch to Imperial units
- Product Code: SOG-18034
- UPC Code: 089836180346
- Package Quantity: 4.41 oz (125 g)
11.7 x 5.1 x 5.1 cm , 0.29 kgSwitch to Imperial units
|Combo Discount:
|- £3.15
- Simply Healthy Living
- Simply Great Taste
- USDA Organic
- Certified Organic by QAI
- Kosher
Literally meaning "seasoning" or "marinade" in Spanish, Adobo seasoning is an all-purpose ethnic blend quickly gaining popularity in southwestern dishes. Our Adobo seasoning features the perfect blend of garlic, onion, and black pepper, along with several other supporting spices.
Suggested Use
Use to add depth to meats, poultry, fish, beans, and rice dishes.
Other Ingredients
Sea salt, organic garlic, organic onion, organic black pepper, organic oregano, organic bay, organic turmeric.
|Supplement Facts
|Serving Size: 1/4 tsp (1 g)
|Servings Per Container: 125
|Amount Per Serving
|% Daily Value
|Total Fat
|0 g
|140 mg
|Total Carbohydrate
|0 g
|0 g
|Percent Daily Values (DV) are based on a 2,000 calorie diet.
Must have Adobo!
Verified Purchase
Must have Adobo!
I was introduced to Adobo Seasoning in the USA. Caribbean workers took a dedicated approach to nourishing, creative, tasty food and used Adobo for marinating, sprinkling and enhancing fish, poultry, beef, pork, lamb & vegetables. Adobo's herb combination is unique, versatile & aromatic. Can your product be made available in larger sizes?
Posted by Millee on May 03, 2017 | Verified Purchase
kind of salty for me
Great flavor and Organic!
Posted by 5006067373079236509 on Mar 06, 2017 | Verified Purchase
Adds so much to my meat sauce. Great flavor and Organic too!
Great Adobo seasoning
Posted by 5228963104130852843 on Mar 02, 2017 | Verified Purchase
I just recently received this seasoning and have now used it twice. It has a great fragrance when the small bottle is opened. I tasted it and the flavor was rich and not salty. I can't have a lot of salt, so this was perfect. I used it in a pot of pinto beans., and the split pea soup tasted much better with some of the Adobo in it. I experiment with my seasonings and try them in all kinds of ways, and this one will be put in my new recipes just like all my others. My favorite seasonings though are the Flavors of Tuscany and the Flavors of Bordeaux.
great product
Posted by 5187133635425514745 on Feb 27, 2017 | Verified Purchase
Great smell. Can use it in any dish. מוצר מעולה. אריזה יפה. כשר מומלץ
All rounded spice
Posted by 4692515838267237658 on Feb 20, 2017 | Verified Purchase
My children love their meat marinated with this spice. Not too salty or particular strong in taste. Good with stews and grills.


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This is a discussion on My 93 Supra TT for sale... within the Vendor Archived Threads forums, part of the Vendor's Forum category; http://www.craigslist.org/eby/car/50010299.html...
Why are you selling it? You just got that beast at a great price!
'92 Civic Si
Hmm...probably selling it to make a tidy profit.
That he would.Originally Posted by JohnnyLevels
'92 Civic Si
Yea, I'm trying to sell it because I got it for a steal and if I can sell it and pay some bills and buy something much more moderate, I'll be in good shape...
I absolutely love the car but it's seriously stupid to keep it and remain in debt when I could maybe sell it and get myself out of debt...I ALMOST sold it for 29k to a guy in my area but he ended up buying a c6 instead...
Well, good luck!
'92 Civic Si
I know that you're not asking more than what others ask......but I just couldn't see spending $28k on a 10-yr old car (albeit with extremely low mileage). I know they can be made into monsters, but I couldn't justify it.
That said, good luck selling! I'm sure you'll have a buyer in no time with the popularity of those cars.
I'm TheBoostCreep, and I approved this message.
yea, I've seen similar ones to mine selling for $40k+ I'm not going that high, but it's all about supply and demand...They only made 7500 MKIV TT supras so they're getting harder and harder to find.Originally Posted by TheBoostCreep
Because of stupid ****s wrecking them like in TFATF lol free bump
True, I hadn't even considered that...so about 7500 turbo supras were sent to the US, and out of those, god knows how many have been wrecked...man, they really are rare...you better jump on this one quick.Originally Posted by xEclipsE RaceRx


text: I just purchased my winter setup for my soon-to-be-delivered ST. I ordered 2 snow tires, 2 all seasons and 4 steelies and it came to about $575. I went with a 15" rim on 195/55 r15's. Living in northern NJ, I need all the sidewall I can get during the winter. Has anyone done this (the 15's) and were there any clearance issues with the calipers? Car should be here in about 2 weeks.......aaaaaaaaaahhhhh!


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SVT XCAL 2 question- Extracting a tune onto your PC
The person I just bought my procharger from also has a XCAL 2 with his 8,10,12 psi tunes. I own a XCAL 2 also and have the SCT point-click-tune on my laptop.
If I bring my laptop with me can I pull the tunes off his xcal 2?
When I get home Ill load his 10psi tune onto my tuner and flash my car. If my wideband says my a/f's are good.. can I put off a local dyno tune till I can save up some more cash? (closest SCT dyno is about 60 miles away)
The only thing im worried about is the differences in PCM codes. Am I headed for disaster?
Any input is welcome
Good question.... I dont "think" you can... or at least I haven't been able to with the ProRacer.
Maybe Tom will be able to shed some light.
Anyone that could email me a base tune for the procharger at 8psi? I have to wait a couple weeks to tune and I need something to get me by on my 80 mile round trip for work.
**UPDATE** well I tried pulling the tune from the xcal 2 and there simply just doesnt seem like there is a way. I see how to put tunes on the xcal 2 but not how to pull the off
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text:
The Premier League's latest offer to the union as a cut of television money is £50million over three years, or £16.6m a year.
The PFA is threatening strike action unless it gets five per cent of the TV fees, or £26m a year.
But Standard Sport has learned that Premier League chief executive Richard Scudamore has the backing of all but one of the 20 Premiership clubs for a hard-line approach. Manchester United are the dissenters.
Scudamore was arguing today that in only two other European countries do the clubs pass on a cut from the television cash. One donation is £1m and the other $1m.
The players will be warned that if they strike, the clubs will fine them two weeks' wages for each week in which they refuse to play.
- More about:
- Manchester United
- Richard Scudamore


text:
pitjman arm clearance
I hava a'38 Ford 350/350 Chev with dropped axle and posie spring. My pit man arm is too low now.
Can I bend it up safely or is there another solution such as older ones or aftermarket ones?
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text:
By this time we've all seen the trailer for Tom Ford's A Single Man (check it here if you have not). A fan of the film, Mr. Ford, and design, decided to give the poster art a second glance. As ck/ck tells us, "Whenever I'm feeling uninspired I like to make movie posters to get my creative juices going again. It always works." It sure does. (ianc)
What To Read Next


text:
Peder Freaks Out (Destiny)
I ran inside to get some buckets for water. We seem to have an abundance of those. The horses gulped the water down rapidly so the boys and I all had to make a few trips. We put them into the village stable to rest. We started for the council house.
"You think the King will find a way to tell us he wants help?" Drake asked.
"I think we should leave him on his own for a bit in the war, get him nice and nervous. The Duke's a powerful man. Surprisingly, many are loyal to him. Make Reagal come to us begging on his knees!" I grunted.
"And let all those innocent people die?! This is life or death!!! We can't let the Duke kill people!!! It doesn't matter if you guys are safe and hidden away! They will find you." Peder exclaimed.
Drake and I stopped and stared at Peder.
"You ok dude?"
"Oh yeah sure it's not like I STARTED A WAR or anything!!!!"
"Hey, it's just as much my fault as it is yours if not more." I shook my head at him. "I helped you run away. Besides, the Duke's a complete and total idiot. Especially when it comes to his daughter's needs."
"How would you know that? You barely met the guy a few weeks ago! You're suddenly an expert?!"
"STOP FREAKING OUT. Everything will be fine. Come on, we've got to make our report." Drake held the door open for us. We all went in to deliver the not so great news.


text:
Cast into the Void
As Simon sat in his frame, running through the last checklist, he struggled to keep his mind on the task at hand instead of what was waiting for him out there. He verified the readings on the analog gagues to confirm what the computers were telling him. Checking his watch, he started a countdown timer as he initiated the final command to release the umbilicals that linked his frame's systems to the Promethius. 48 hours of life supports were now between him and the great beyond.
"Promethius, Talon One reporting ready for launch." he said into his helmet mounted mic.
"Talon One, Promethius, Confirmed Launch Status. Mark 30 seconds. Catapult charging. Your flight is go for contact. Good luck." The FOC replied.
"Flight, Talon One, Check in." Simon queried his flight group.
"Talon Two, Confirmed for Launch." came the voice of Ling, his wingman. The slight inflections in her speach betraying her family's asian background.
"Talon Three, Confirmed for Launch." chimed in the voice of Carl. The distinctly russian sound of his words was unmistakeable.
"Talon Four, Confirmed for Launch." filled his ears with the melodious southern drawl of Liz, the pilot of the ElInt frame.
Simon gave one last command, "Flight, as briefed, form up at waypoint one after launch." He tightened his grip on the two multi-axis control sticks and set his feet more firmly against the pedals. His thumb pressed the launch button and the catapult began to cycle through the capacitors that powered the magnetic loops ahead of him in the launch tube. Six g's of acceleration flung him out of the Promethius with startling suddenness. As his frame passed the final ring, the stabalization system came online and corrected for any tumble that may have been introduced by the launch. A moment of weightlessness passed over him as the high pressure ion thruster took a moment to come to life, settling into a steady half G of acceleration.
He scanned over his information screens and saw that his flight had launched successfully and that the object they were being sent to investigate was still where they found it. They were forming up as expected and none of the craft were showing any problems.
"Promethius, Talon One, go for mission."
"Roger, confirmed."
The quarter of diminuitive craft gently hurtled off into the darkness of space towards the mysterious craft that had been spotted orbiting the sun on the fringes of the solar system.


text:
Anyone who owns a Mercedes-Benz knows that when it comes to maintaining their car, truck, or SUV only the highest quality replacement parts will do. It's not a regular occurrence that you find yourself in need of a replacement Alternator to fix your automobile. You bought your 300SEL because its performance and German engineering agreed with your nature; so why would you be okay with second rate when it comes to the highest quality auto parts? Make no mistake, you didn't buy your 300SEL unless you knew that you wanted long-lasting quality and dependability both rolled up into one vehicle.
Without some key electrical parts, your engine wouldn't be able to stay running. Your Mercedes-Benz 300SEL alternator uses a drive belt to harness the rotation of the crankshaft to spin its own pulley. Inside that alternator, a constant supply of current for your car or truck is generated as a pair of metal claws and brushes spin around a coil; creating a powerful electromagnetic field. The energy from your alternator goes back to the battery and keeps it charged, while also supplying voltage to circuits that power your vehicle's lighting systems, HVAC system, and more on your Mercedes-Benz 300SEL.
Don't let a Alternator repair bring about the demise of your car, truck, or SUV, and don't gamble with its condition by using anything but the highest quality replacement parts. Trust in the value of the parts you get from carpartsdiscount.com and save time and money on all your upcoming repairs. Bring your 300SEL back to life with the highest quality new or rebuilt parts from the experts at Car Parts Discount. When it comes to Mercedes-Benz 300SEL Alternator parts, you can find them for 1991, 1990, 1989, 1988, 1973, 1972, 1971, 1970, 1969, 1968 models by clicking the appropriate year below.


text:
ED Magedson – Founder
Ripoff Report
Pure Garcinia12760 Park Ave. 1610 Riverton, Utah USA
Pure Garcinia Pure Garcinia Cabogia,Worlds Best Garcinia,'Garciniaburn Was only suppose to pay shipping of 2.95, but was charged 159.00 and then charged 49.95 four times. Its been two months now and fighting endlessly to finally get 159.00 and one 49.95 charge back. I'm still trying to get the other 3 charges of 49.95 back. they say that its been refunded but has not. i have all the bank statements to prove it has not come to my bank. They print up phony invoices showing you've been credited. This company will take your money if they have your card number. The 4 charges for 49.95, Ihave no idea what they were for. They just took it. Riverton Utah
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
On 12/31/13 I order a free trial bottle of Garcinia pills for my wife for only the 2. [continued below]....
This report was posted on Ripoff Report on 02/23/2014 07:39 PM and is a permanent record located here: http://www.ripoffreport.com/reports/pure-garcinia/riverton-utah-84065/pure-garcinia-pure-garcinia-cabogiaworlds-best-garciniagarciniaburn-was-only-suppose-t-1125950. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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text: Home Gay Porn Videos FreshMen – Solo – Issue 7 – Shane Sanders Gay Porn VideosSolo FreshMen – Solo – Issue 7 – Shane Sanders November 24, 2016 139 SHARE Facebook Twitter Shane is one of those boys who we didn't put on exclusive contract but we keep shooting with on a case by case basis. We are certainly interested in your input if to slow down or speed things up with him more. Download full video from:


text:
- Long Lasting Impact Doors in Farmersville, CA
- Certified Farmersville Impact Door Installers
- Free Estimates on Impact Doors in Farmersville, CA
Impact Doors in Farmersville, CA
Impact doors in Farmersville, CA are a great way to protect your home against damage, so it is important that you take the time to look into them. You will find that Farmersville impact doors are perfect for those who live in areas that experience severe weather on a regular basis. If you don't want high winds to damage your doors, you will definitely be interested in what these ones have to offer. Impact doors are also great for security purposes, as they are made of super strong reinforced materials.
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Find the Best Quality Impact Doors - Farmersville, CA
The impact doors in Farmersville, CA will protect you and your family from intruders, as they are extremely difficult to break down and get through. If you want to increase your home's security, it is definitely a good idea to look into the impact front doors Farmersville, CA has to offer. It is very important to protect the front door of your home, as it is typically where intruders try to get in. Impact front doors are very strong and they are able to withstand a massive amount of force, so you won't have to worry about anyone breaking in. With so many benefits, impact doors are a great investment for all homeowners.
Impact Doors Companies
Deniz Garage Doors
P O Box 924
Exeter, CA 93221
Exeter, CA 93221
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G. R. Garage Doors
PO Box 941
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Booklady, The
436 Gearey Ave
Exeter, CA 93221


text:
ED Magedson – Founder
Ripoff Report
Craigsflagger.netInternet United States of America
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Fix it the right way.
Corporate Advocacy Program™
This report was posted on Ripoff Report on 01/13/2013 11:21 PM and is a permanent record located here: http://www.ripoffreport.com/reports/craigsflaggernet/internet/craigsflaggernet-craigsflaggerme-adrien-stone-andy-stone-serious-ripoff-denver-inte-996375. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 Consumer Comment
Software works great, Highly recommend Craigsflagger.me
SUBMITTED: Tuesday, June 18, 2013POSTED: Tuesday, June 18, 2013
I purchased Craigsflagger.me at I time when my competitors were flagging my ads down daily. I was able to fire back at my competitors and better yet I was able to post in a way which almost automatically made my ads stick. The software works great.
The Members tutorials are the most advanced and up to date information anywhere regarding anything to do with being a success on craigslist. Craigslist is always changing. The Software and Lifetime membership $34.95 is great deal, They only ask that you get your update by requesting through there e-mail and there support is exceptional! Thank You! Craigsflagger.me.
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text:
Welcome to Model School – a school of diversity celebrating the uniqueness of each child.
Our staff is dedicated to developing classrooms consisting of creative, connected activities that enhance learning and develop appreciation of the diversity within our population.
We work together to provide a safe, caring environment. Classroom teachers, specialty staff, and support staff model the behavior and attitude of courtesy and responsibility. We celebrate and recognize students who demonstrate these qualities. At the same time, Model staff holds high academic expectations for students. Students are encouraged to complete assignments that always demonstrate their personal best.
Teachers reinforce our students' responsibility in completing work on a timely basis. After school homework assistance is provided for grades 4-5. Feedback is immediate so children can make corrections in their concept and skill acquisition.
Model's Bulldog Beliefs:


text:
Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic β cells and is required for the postprandial spike in insulin secretion. Using high-resolution microscopy, we have identified a subset of docked insulin granules in human β cells and rat-derived clonal insulin 1 (INS1) cells for which localized Ca2+ influx triggers exocytosis with high probability and minimal latency. This immediately releasable pool (IRP) of granules, identified both structurally and functionally, was absent in β cells from human T2D donors and in INS1 cells cultured in fatty acids that mimic the diabetic state. Upon arrival at the plasma membrane, IRP granules slowly associated with 15 to 20 L-type channels. We determined that recruitment depended on a direct interaction with the synaptic protein Munc13, because expression of the II–III loop of the channel, the C2 domain of Munc13-1, or of Munc13-1 with a mutated C2 domain all disrupted L-type channel clustering at granules and ablated fast exocytosis. Thus, rapid insulin secretion requires Munc13-mediated recruitment of L-type Ca2+ channels in close proximity to insulin granules. Loss of this organization underlies disturbed insulin secretion kinetics in T2D.
Nikhil R. Gandasi, Peng Yin, Michela Riz, Margarita V. Chibalina, Giuliana Cortese, Per-Eric Lund, Victor Matveev, Patrik Rorsman, Arthur Sherman, Morten G. Pedersen, Sebastian Barg
The clinical utility of inhibiting cytochrome P450 17A1 (CYP17), a cytochrome p450 enzyme that is required for the production of androgens, has been exemplified by the approval of abiraterone for the treatment of castration-resistant prostate cancer (CRPC). Recently, however, it has been reported that CYP17 inhibitors can interact directly with the androgen receptor (AR). A phase I study recently reported that seviteronel, a CYP17 lyase–selective inhibitor, demonstrated a sustained reduction in prostate-specific antigen in a patient with CRPC, and another study showed seviteronel's direct effects on AR function. This suggested that seviteronel may have therapeutically relevant activities in addition to its ability to inhibit androgen production. Here, we have demonstrated that CYP17 inhibitors, with the exception of orteronel, can function as competitive AR antagonists. Conformational profiling revealed that the CYP17 inhibitor–bound AR adopted a conformation that resembled the unliganded AR (apo-AR), precluding nuclear localization and DNA binding. Further, we observed that seviteronel and abiraterone inhibited the growth of tumor xenografts expressing the clinically relevant mutation AR-F876L and that this activity could be attributed entirely to competitive AR antagonism. The results of this study suggest that the ability of CYP17 inhibitors to directly antagonize the AR may contribute to their clinical efficacy in CRPC.
John D. Norris, Stephanie J. Ellison, Jennifer G. Baker, David B. Stagg, Suzanne E. Wardell, Sunghee Park, Holly M. Alley, Robert M. Baldi, Alexander Yllanes, Kaitlyn J. Andreano, James P. Stice, Scott A. Lawrence, Joel R. Eisner, Douglas K. Price, William R. Moore, William D. Figg, Donald P. McDonnell
Despite the benefit of insulin, blockade of autoimmune attack and regeneration of pancreatic islets are ultimate goals for the complete cure of type 1 diabetes (T1D). Long-term consumption of ω-3 polyunsaturated fatty acids (PUFAs) is known to suppress inflammatory processes, making these fatty acids candidates for the prevention and amelioration of autoimmune diseases. Here, we explored the preventative and therapeutic effects of ω-3 PUFAs on T1D. In NOD mice, dietary intervention with ω-3 PUFAs sharply reduced the incidence of T1D, modulated the differentiation of Th cells and Tregs, and decreased the levels of IFN-γ, IL-17, IL-6, and TNF-α. ω-3 PUFAs exerted similar effects on the differentiation of CD4+ T cells isolated from human peripheral blood mononuclear cells. The regulation of CD4+ T cell differentiation was mediated at least in part through ω-3 PUFA eicosanoid derivatives and by mTOR complex 1 (mTORC1) inhibition. Importantly, therapeutic intervention in NOD mice through nutritional supplementation or lentivirus-mediated expression of an ω-3 fatty acid desaturase, m
Xinyun Bi, Fanghong Li, Shanshan Liu, Yan Jin, Xin Zhang, Tao Yang, Yifan Dai, Xiaoxi Li, Allan Zijian Zhao
It is well established that somatic genomic changes can influence phenotypes in cancer, but the role of adaptive changes in developmental disorders is less well understood. Here we have used next-generation sequencing approaches to identify de novo heterozygous mutations in sterile α motif domain–containing protein 9 (
Federica Buonocore, Peter Kühnen, Jenifer P. Suntharalingham, Ignacio Del Valle, Martin Digweed, Harald Stachelscheid, Noushafarin Khajavi, Mohammed Didi, Angela F. Brady, Oliver Blankenstein, Annie M. Procter, Paul Dimitri, Jerry K.H. Wales, Paolo Ghirri, Dieter Knöbl, Brigitte Strahm, Miriam Erlacher, Marcin W. Wlodarski, Wei Chen, George K. Kokai, Glenn Anderson, Deborah Morrogh, Dale A. Moulding, Shane A. McKee, Charlotte M. Niemeyer, Annette Grüters, John C. Achermann
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular disorder that is characterized by extreme variability in symptoms, with females being less severely affected than males and presenting a higher proportion of asymptomatic carriers. The sex-related factors involved in the disease are not known. Here, we have utilized myoblasts isolated from FSHD patients (FSHD myoblasts) to investigate the effect of estrogens on muscle properties. Our results demonstrated that estrogens counteract the differentiation impairment of FSHD myoblasts without affecting cell proliferation or survival. Estrogen effects are mediated by estrogen receptor β (ERβ), which reduces chromatin occupancy and transcriptional activity of double homeobox 4 (DUX4), a protein whose aberrant expression has been implicated in FSHD pathogenesis. During myoblast differentiation, we observed that the levels and activity of DUX4 increased progressively and were associated with its enhanced recruitment in the nucleus. ERβ interfered with this recruitment by relocalizing DUX4 in the cytoplasm. This work identifies estrogens as a potential disease modifier that underlie sex-related differences in FSHD by protecting against myoblast differentiation impairments in this disease.
Emanuela Teveroni, Marsha Pellegrino, Sabrina Sacconi, Patrizia Calandra, Isabella Cascino, Stefano Farioli-Vecchioli, Angela Puma, Matteo Garibaldi, Roberta Morosetti, Giorgio Tasca, Enzo Ricci, Carlo Pietro Trevisan, Giuliana Galluzzi, Alfredo Pontecorvi, Marco Crescenzi, Giancarlo Deidda, Fabiola Moretti
Obesity causes insulin resistance, and PPARγ ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat diet (HFD) has major effects on visceral epididymal adipose tissue (eWAT). Here, we report that HFD-induced obesity in B6 mice also altered the activity of gene regulatory elements and genome-wide occupancy of PPARγ. Rosiglitazone treatment restored insulin sensitivity in obese B6 mice, yet, surprisingly, had little effect on gene expression in eWAT. However, in subcutaneous inguinal fat (iWAT), rosiglitazone markedly induced molecular signatures of brown fat, including the key thermogenic gene
Raymond E. Soccio, Zhenghui Li, Eric R. Chen, Yee Hoon Foong, Kiara K. Benson, Joanna R. Dispirito, Shannon E. Mullican, Matthew J. Emmett, Erika R. Briggs, Lindsey C. Peed, Richard K. Dzeng, Carlos J. Medina, Jennifer F. Jolivert, Megan Kissig, Satyajit R. Rajapurkar, Manashree Damle, Hee-Woong Lim, Kyoung-Jae Won, Patrick Seale, David J. Steger, Mitchell A. Lazar
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses to physiologic and pathophysiologic stresses. Here, we have reported that a single member of the evolutionarily conserved miR-7 family, miR-7a2, is essential for normal pituitary development and hypothalamic-pituitary-gonadal (HPG) function in adulthood. Genetic deletion of
Kashan Ahmed, Mary P. LaPierre, Emanuel Gasser, Rémy Denzler, Yinjie Yang, Thomas Rülicke, Jukka Kero, Mathieu Latreille, Markus Stoffel
Primary adrenal insufficiency is life threatening and can present alone or in combination with other comorbidities. Here, we have described a primary adrenal insufficiency syndrome and steroid-resistant nephrotic syndrome caused by loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1). SGPL1 executes the final decisive step of the sphingolipid breakdown pathway, mediating the irreversible cleavage of the lipid-signaling molecule sphingosine-1-phosphate (S1P). Mutations in other upstream components of the pathway lead to harmful accumulation of lysosomal sphingolipid species, which are associated with a series of conditions known as the sphingolipidoses. In this work, we have identified 4 different homozygous mutations, c.665G>A (p.R222Q), c.1633_1635delTTC (p.F545del), c.261+1G>A (p.S65Rfs*6), and c.7dupA (p.S3Kfs*11), in 5 families with the condition. In total, 8 patients were investigated, some of whom also manifested other features, including ichthyosis, primary hypothyroidism, neurological symptoms, and cryptorchidism.
Rathi Prasad, Irene Hadjidemetriou, Avinaash Maharaj, Eirini Meimaridou, Federica Buonocore, Moin Saleem, Jenny Hurcombe, Agnieszka Bierzynska, Eliana Barbagelata, Ignacio Bergadá, Hamilton Cassinelli, Urmi Das, GOSgene, Ruth Krone, Bulent Hacihamdioglu, Erkan Sari, Ediz Yesilkaya, Helen L. Storr, Maria Clemente, Monica Fernandez-Cancio, Nuria Camats, Nanik Ram, John C. Achermann, Paul P. Van Veldhoven, Leonardo Guasti, Debora Braslavsky, Tulay Guran, Louise A. Metherell
The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic glucose production (HGP), and hepatic ketogenesis by 50% within 6 hours and were independent of any changes in plasma glucagon concentrations; these effects were abrogated by coinfusion of corticosterone. Treating leptin- and corticosterone-infused rats with an adipose triglyceride lipase inhibitor blocked corticosterone-induced increases in plasma glucose concentrations and rates of HGP and ketogenesis. Similarly, adrenalectomized type 1 diabetic (T1D) rats exhibited decreased rates of lipolysis, HGP, and ketogenesis; these effects were reversed by corticosterone infusion. Leptin-induced decreases in lipolysis, HGP, and ketogenesis in DKA were also nullified by relatively small increases (15 to 70 pM) in plasma insulin concentrations. In contrast, the chronic glucose-lowering effect of leptin in a STZ-induced mouse model of poorly controlled T1D was associated with decreased food intake, reduced plasma glucagon and corticosterone concentrations, and decreased ectopic lipid (triacylglycerol/diacylglycerol) content in liver and muscle. Collectively, these studies demonstrate marked differences in the acute insulin-independent effects by which leptin reverses fasting hyperglycemia and ketoacidosis in a rodent model of DKA versus the chronic pleotropic effects by which leptin reverses hyperglycemia in a non-DKA rodent model of T1D.
Rachel J. Perry, Liang Peng, Abudukadier Abulizi, Lynn Kennedy, Gary W. Cline, Gerald I. Shulman
Type 2 diabetes is thought to involve a compromised β cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult β cell identity and function. PAX6 was downregulated in β cells of diabetic
Avital Swisa, Dana Avrahami, Noa Eden, Jia Zhang, Eseye Feleke, Tehila Dahan, Yamit Cohen-Tayar, Miri Stolovich-Rain, Klaus H. Kaestner, Benjamin Glaser, Ruth Ashery-Padan, Yuval Dor
Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene
Lisa C. Burnett, Charles A. LeDuc, Carlos R. Sulsona, Daniel Paull, Richard Rausch, Sanaa Eddiry, Jayne F. Martin Carli, Michael V. Morabito, Alicja A. Skowronski, Gabriela Hubner, Matthew Zimmer, Liheng Wang, Robert Day, Brynn Levy, Ilene Fennoy, Beatrice Dubern, Christine Poitou, Karine Clement, Merlin G. Butler, Michael Rosenbaum, Jean Pierre Salles, Maithe Tauber, Daniel J. Driscoll, Dieter Egli, Rudolph L. Leibel
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoproteins to guide covalent modifications of ribosomal and small nuclear RNAs in the nucleus. Recent studies have also uncovered additional non-canonical roles for snoRNAs. However, the physiological contributions of these small RNAs are largely unknown. Here, we selectively deleted four snoRNAs encoded within the introns of the ribosomal protein L13a (
Jiyeon Lee, Alexis N. Harris, Christopher L. Holley, Jana Mahadevan, Kelly D. Pyles, Zeno Lavagnino, David E. Scherrer, Hideji Fujiwara, Rohini Sidhu, Jessie Zhang, Stanley Ching-Cheng Huang, David W. Piston, Maria S. Remedi, Fumihiko Urano, Daniel S. Ory, Jean E. Schaffer
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose production, yet successfully stimulates de novo lipogenesis. The mechanisms underlying this dysregulation remain controversial. Here, we hypothesized that carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic genes, plays a central role in this paradox. Administration of fructose increased hepatic hexose-phosphate levels, activated ChREBP, and caused glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in mice. Activation of ChREBP was required for the increased expression of glycolytic and lipogenic genes as well as glucose-6-phosphatase (
Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman
Ghrelin is an orexigenic gastric peptide hormone secreted when caloric intake is limited. Ghrelin also regulates blood glucose, as emphasized by the hypoglycemia that is induced by caloric restriction in mouse models of deficient ghrelin signaling. Here, we hypothesized that activation of β1-adrenergic receptors (β1ARs) localized to ghrelin cells is required for caloric restriction–associated ghrelin release and the ensuing protective glucoregulatory response. In mice lacking the β1AR specifically in ghrelin-expressing cells, ghrelin secretion was markedly blunted, resulting in profound hypoglycemia and prevalent mortality upon severe caloric restriction. Replacement of ghrelin blocked the effects of caloric restriction in β1AR-deficient mice. We also determined that treating calorically restricted juvenile WT mice with beta blockers led to reduced plasma ghrelin and hypoglycemia, the latter of which is similar to the life-threatening, fasting-induced hypoglycemia observed in infants treated with beta blockers. These findings highlight the critical functions of ghrelin in preventing hypoglycemia and promoting survival during severe caloric restriction and the requirement for ghrelin cell–expressed β1ARs in these processes. Moreover, these results indicate a potential role for ghrelin in mediating beta blocker–associated hypoglycemia in susceptible individuals, such as young children.
Bharath K. Mani, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Chelsea Hepler, Jeffrey M. Zigman
Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the insulin receptor (M-IR–/– mice), the IGF-1 receptor (M-IGF1R–/– mice), or both (MIGIRKO mice), we assessed the relative contributions of IR and IGF1R signaling to muscle proteostasis. In differentiated muscle, IR expression predominated over IGF1R expression, and correspondingly, M-IR–/– mice displayed a moderate reduction in muscle mass whereas M-IGF1R–/– mice did not. However, these receptors serve complementary roles, such that double-knockout MIGIRKO mice displayed a marked reduction in muscle mass that was linked to increases in proteasomal and autophagy-lysosomal degradation, accompanied by a high-protein-turnover state. Combined muscle-specific deletion of
Brian T. O'Neill, Kevin Y. Lee, Katherine Klaus, Samir Softic, Megan T. Krumpoch, Joachim Fentz, Kristin I. Stanford, Matthew M. Robinson, Weikang Cai, Andre Kleinridders, Renata O. Pereira, Michael F. Hirshman, E. Dale Abel, Domenico Accili, Laurie J. Goodyear, K. Sreekumaran Nair, C. Ronald Kahn
Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (
Davide Calebiro, Elisa S. Grassi, Markus Eszlinger, Cristina L. Ronchi, Amod Godbole, Kerstin Bathon, Fabiana Guizzardi, Tiziana de Filippis, Knut Krohn, Holger Jaeschke, Thomas Schwarzmayr, Rifat Bircan, Hulya Iliksu Gozu, Seda Sancak, Marek Niedziela, Tim M. Strom, Martin Fassnacht, Luca Persani, Ralf Paschke
A rise in the occurrence of obesity has driven exploration of its underlying genetic basis and potential targets for intervention. GWAS studies have identified obesity susceptibility pathways involving several neuropeptides that control energy homeostasis, suggesting that variations in the genes that regulate food intake and energy expenditure may contribute to obesity. In this study, we identified 5 additional obesity loci, including a neuronal orphan GPCR called
Jing Cui, Yi Ding, Shu Chen, Xiaoqiang Zhu, Yichen Wu, Mingliang Zhang, Yaxin Zhao, Tong-Ruei R. Li, Ling V. Sun, Shimin Zhao, Yuan Zhuang, Weiping Jia, Lei Xue, Min Han, Tian Xu, Xiaohui Wu
A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that the intestinal microbiota modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss. In murine models, sex steroid deficiency increased gut permeability, expanded Th17 cells, and upregulated the osteoclastogenic cytokines TNFα (TNF), RANKL, and IL-17 in the small intestine and the BM. In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogenic cytokine production, stimulate bone resorption, and cause trabecular bone loss, demonstrating that the gut microbiota is central in sex steroid deficiency–induced trabecular bone loss. Furthermore, we demonstrated that twice-weekly treatment of sex steroid–deficient mice with the probiotics
Jau-Yi Li, Benoit Chassaing, Abdul Malik Tyagi, Chiara Vaccaro, Tao Luo, Jonathan Adams, Trevor M. Darby, M. Neale Weitzmann, Jennifer G. Mulle, Andrew T. Gewirtz, Rheinallt M. Jones, Roberto Pacifici
Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic and lipotoxic conditions on human islets in vivo and developed and/or used 3 complementary models that allowed comparison of the effects of hyperglycemic and/or insulin-resistant metabolic stress conditions on human and mouse islets, which responded quite differently to these challenges. Hyperglycemia and/or insulin resistance impaired insulin secretion only from human islets in vivo. In human grafts, chronic insulin resistance decreased antioxidant enzyme expression and increased superoxide and amyloid formation. In human islet grafts, expression of transcription factors
Chunhua Dai, Nora S. Kayton, Alena Shostak, Greg Poffenberger, Holly A. Cyphert, Radhika Aramandla, Courtney Thompson, Ioannis G. Papagiannis, Christopher Emfinger, Masakazu Shiota, John M. Stafford, Dale L. Greiner, Pedro L. Herrera, Leonard D. Shultz, Roland Stein, Alvin C. Powers
A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of adipose energy stores by hydrolysis of triglycerides through β-adrenergic receptor (βARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1) through mTORC1, is also triggered by PKA activation in both mouse and human adipocytes. Mice with mTORC1 impairment, either through adipocyte-specific deletion of
Dianxin Liu, Marica Bordicchia, Chaoying Zhang, Huafeng Fang, Wan Wei, Jian-Liang Li, Adilson Guilherme, Kalyani Guntur, Michael P. Czech, Sheila Collins


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Pitcairn Narakobe
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Expanded Dune
This article or section refers to elements from Expanded Dune.
- "Every large-scale movement-political, religious, or military-hinges upon epochal events."
- ―Pitcairn Narakobe[src]
Pitcairn Narakobe was a League of Nobles military philosopher
- Dune: The Butlerian Jihad (Epigraph only)


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Ford On Achievement
The man who will use his skill and constructive imagination to see how much he can give for a dollar, instead of how little he can give for a dollar, is bound to succeed.
Henry Ford, car executive
Lombardi On Effort
The only place success comes before work is in the dictionary.
Vince Lombardi, football coach
Emerson On Teamwork
No member of a crew is praised for the rugged individuality of his rowing.
Ralph Waldo Emerson, poet
Huntsman On Contrition
Watergate wasn't so much a burglary as it was the failure to recognize mistakes, to take responsibility for them and to apologize accordingly.
Jon Huntsman Sr., chemical executive
Roosevelt On Self-Motivation
You must do the things you think you cannot do.
Eleanor Roosevelt, first lady


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- Tough exterior and durable foam and padded anti-shock lining, shockproof, water resistant and dustproof
- Adjustable compartments and dividers combinations meet all your needs
- Additional pockets for 13-inch laptop, pad, smartphone, and tripod can also be included, large enough space and multifunction
- Comfortable padded shoulder straps relieve the stress and convenient to take out the camera
- Backpack your happy journey from here
- Fit for Canon 50D, 60D, 100D, 550D, 600D, 1000D, etc. and for Nikon D60, D90, D3100, D3200, D5200, D7000, etc.
Folded size ( L x W x H ): 30cm x 23cm x 15cm
The cameras, pad, smartphone, tripod, laptop and other accessories showed in the pictures are not included.
|Dimensions and Weight
|Package Contents
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Chelsea's inconsistent form earlier in the campaign looked to have undermined their challenge for the Barclays Premier League title, but they have found their way under Guus Hiddink to move to within four points of leaders Manchester United.
"This result sets the tone really," said Lampard. "Everything is still up for grabs, even though we are behind in the league. It is important that we keep to the standard we played against Liverpool."
He added: "When we look at the strength of our team throughout the pitch, we are as good as anybody.
"There have been times this season when we have not performed at our best - and we have to take responsibility for that as individuals and as a team. But it is done and in the past.
"All we can affect is what we are going to do in the future. There have been times when we've been below par this season. But when we play like we did against Liverpool, then we can get such results.
"We hope if we can carry on playing like that we will put fear into a lot of teams. But we must keep to those high standards."
Meanwhile, Chelsea moved to quash reports AC Milan coach Carlo Ancelotti has accepted a £5.8million deal to replace interim boss Hiddink.
Hiddink has maintained he will return to manage Russia at the end of the season but the Blues' resurgent form in recent weeks, epitomised bv the Anfield victory, has strengthened his chances of remaining on a more permanent basis.
- More about:
- Chelsea F.c.
- Guus Hiddink
- Manchester United
- Premier League


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- Senate leaders announced a budget compromise Wednesday that will raise the debt ceiling and re-open the government. In Play's Chris Cillizza breaks down which political players came out of the deal on top and which ones did not. ()


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Category:Maps of Pike County, Ohio
Pike County is in Ohio in the United States. Its county seat is Waverly.
This category has only the following subcategory.
Media in category "Maps of Pike County, Ohio"
The following 14 files are in this category, out of 14 total.
- OHMap-doton-Beaver.png 10 KB
- OHMap-doton-buchanan.png 25 KB
- OHMap-doton-Jasper.png 17 KB
- OHMap-doton-Latham.png 17 KB
- OHMap-doton-Piketon.png 10 KB
- OHMap-doton-Waverly.png 10 KB


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Things do go wrong in life. No one escapes death, sickness, accidents, crime or theft. In fact, we cannot predict these misfortunes and, in some instances, we cannot prevent them. But having the right insurance can give you peace of mind if things go wrong.
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which offers maximum choice and flexibility as well
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your personal needs and circumstances. We recommend that you
speak to a financial planner to help you select the most
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Your death does not have to mean financial
difficulty for your family. Life insurance can help
your loved ones take care of their needs and
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impact on your lifestyle and the treatment can be
expensive. This cover relieves the financial
burden on you and your family.
The long-term financial impact of not being able to work
because of serious illness or injury can be significant.
Enjoy peace of mind with a regular income.
Protect the things you own from unforeseen events so that you can maintain your lifestyle


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What would a Québec roster look like?
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Originally Posted by
Jason Pominville plays for the United States. I know he was born in Quebec, but since you didn't include Stastny, I'm not completely sure why Pominville is included.
Pominville wasn't just born in Quebec, he was raised and trained in hockey there. He's a Canadian hockey player from Quebec, and his mother's nationality (along with being a late bloomer) is what enabled him to play for USA. Stastny was born in Quebec, but that's not where he was trained in hockey. He's an American hockey player.
I like the roster in the OP, though I think Perron has to make it over Gagne or Tanguay, and Talbot could get consideration as well. Jason Demers might be better than Bergeron in defence, as Quebec could use more defensive ability on the back end. The forward group is quite good with very good balance and lots of responsible forwards. The defence is suspect, but at least comparable with most of the European teams. Goaltending is pretty good. Quebec wouldn't be a favourite, but you wouldn't be thrilled to play them either.
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Lot 2 Giese, Alma Center WI 54611 $50,000
Features of Lot 2 Giese Alma Center WI 54611
- Lots for Sale
- Status: Active
- Estimated Age: Not Available
- Est. Acreage: 5
- Est. Acreage: >= 1, >= 1/2, >= 5
- School District: Alma Center/Merrillan/Humbird
- Body of Water: Judkins
- County: Jackson
- Property Taxes: $80
- Property Tax Year: 2015
- Listing Company: Clearview Realty Llc
- Listing Agent: Alisha Southwood
Property Description for Lot 2 Giese Alma Center WI 54611
Lot 2 Giese Alma Center WI 54611 - Building Site/Hunting Camp With 5.39 Acres Of Mature Woods, Surrounded By Corn & Bean Fields. Pole Building Structure W/ Concrete Base & Electric Established On Site. Prime Hunting, Woods & Creek Frontage
Building and Construction
- Construction Type: E
Land Features
- Topography: Level, Rolling/Hilly, Wooded
- Zoning: Residential
- Waterfront/Access: N
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|Nov 20 2015 3:29PM
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Buyer understands that the information which is contained on Data pages is obtained from a number of different sources and which has not been independently verified or confirmed by the various real estate brokers and agents who have been and are involved in this transaction. If any particular measurement or data element is important or material to buyer, Buyer assumes all responsibility and liability to research, verify and confirm said data element and measurement. REALTOR *MLS* Equal Housing Opportunity


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I got a copy of WinZip last week for my x64 box because I needed to unzip a gzip file. I later realized that since I'm running a 64-bit version of vista, the handy WinZip context menu shell extenstions won't work (unless I run a 32-instance of explorer.exe). This was a bummer because I like being able to right click on an archive and extract it. I know Windows has had built in support for this since XP but it requires me to click one more time than winzip does so it's not as quick. In any case, not having the optio nto use WinZip, I wanted to go back to using the built in windows handler for zip files since it works fine (except for that one extra click I have to do).
How do you restore the default .zip file association in Windowx XP or Vista? It wasn't as simple as right clicking and selecting "Open with.." which is what I tried for about 5 minutes. turns out you can restore it this way though:
cmd /c assoc .zip=CompressedFolder
Thanks goes to Ramesh Srinivasan for pointing out how to do this: http://windowsxp.mvps.org/zipfldr.htm


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Sustainable Construction Materials: Copper Slag, part of a series of five, aims to promote the use of sustainable construction materials. It is different from the norm, with its uniqueness lying in the development of a data matrix sourced from 525 publications and contributed by 1107 authors from 442 institutions in 48 countries from 1970 to 2016. This volume's main focus lies in copper slag as a construction material, systematically analyzing, evaluating, and modeling the information for use in cement, concrete, ceramics, geotechnics, and road pavement applications.
Related environmental issues, case studies, and standards are also discussed. The book helps users avoid repetitive research and save valuable resources, giving them more latitude to explore new research to progress the use of sustainable construction materials. It is structured in an incisive and easy to digest manner.
As an excellent reference source, the book is particularly suited for researchers, academics, design engineers, specifiers, contractors, developers, and certifying and regulatory authorities who seek to promote sustainability within the construction sector.
To view this DRM protected ebook on your desktop or laptop you will need to have Adobe Digital Editions installed. It is a free software. We also strongly recommend that you sign up for an AdobeID at the Adobe website. For more details please see FAQ 1&2. To view this ebook on an iPhone, iPad or Android mobile device you will need the Adobe Digital Editions app, or BlueFire Reader or Txtr app. These are free, too. For more details see this article.
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Living the 'pre-solvent' life.Posted by Donna Freedman on May 4, 2017 | 54 comments
(Happy Throwback Thursday, everyone! This article originally ran on July 3, 2015. Its sentiments are as valid to me today as they were back then.)
Here's today's neologism, and it's a great one: "pre-solvent." It comes from a comment on one a Money Talks News article called "The real reason Americans struggle to save."
The article cited a couple of surveys that put the fault not in our stars, but in our cards: "Lifestyle spending" and "lack of financial discipline" kept anywhere from 44 to 71 percent of respondents living paycheck to paycheck and/or prevented them from achieving financial goals.
I'd like to point out that underemployment, lack of education and impossible-to-pay medical bills can also hinder the ability to save. But I agree that the "buy now, figure out how to pay for it later" attitude is definitely nudging some folks toward insolvency.
Which brings us to pre-solvency. A commenter named "Y2K Jillian" writes that she and her husband lived paycheck to paycheck for years and loathed the lifestyle. But change happened.
How? "Gradually, gradually." Which is how I'd bet it happens for a lot of people.
read more


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Rent 2istab apartment. Room insulated, beyond repair. Built-in kitchen appliances, fully furnished, all the necessary home appliances. Good traffic. Next supernetto stores and Maxima. Next to the kindergarten, school, pharmacy, medical center.
New home – Riga, Latvia
170,000 €
2,236 € /m²
Total area: 76 m²
- 6 floor
- 7-floor building
- Total rooms: 2


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Impress your friends this Fall with this Brown Butter Cake with sugared fig filling! It's all easy with Foodstirs Cake Mix and Organic Frosting Mix! Created by Baker's Circle Ambassador, Kait Hanson.
1 cup fig compote
2 tbsp. brown sugar
2 Foodstirs Frosting Mixes
1 box Foodstirs Simply Sweet Vanilla Cake Mix, using ingredients on box. Before you add in the 9 tablespoons of butter, brown it in a saucepan over medium heat
1 tbsp. brown sugar
Preheat your oven to 350 degrees.
In a bowl, mix together 1 Foodstirs Frosting Mix. Set aside.
In a separate bowl, mix together 1 Foodstirs Frosting Mix and add 2 tbsp. brown sugar and 1 cup fresh fig compote. Set aside.
In a small saute pan, brown 9 tablespoons of butter over medium heat.
In a third bowl, combine 1 box of Foodstirs Simply Sweet Vanilla Cake Mix, yogurt, eggs, milk and browned butter. Mix well.
Pour equally into 2-8 inch pans and bake for 20-25 minutes. Optional: Use two specialty pans made specifically for stuffing cakes!
Remove from oven and let cool completely.
Fill both cakes with sugared fig frosting. *If you are not using specialty pans, spread the sugared fig frosting between the two cake halves like a sandwich!
Stack the cakes.
Using the second Foodstirs frosting mixture, lightly frost, or crumb coat, your cake.
Garnish with fresh figs or flowers.


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Indonesian authorities suspect separatists were behind the slaying of eight soldiers in Indonesian Papua on Thursday, in the biggest attack on security forces in the region's recent history.
Gunmen shot dead the eight and wounded another in two separate incidents among the mountains of Puncak Jaya district, a known hideout for rebels where attacks on police and soldiers are common.
Co-ordinating Security Minister Djoko Suyanto said the government "strongly condemned the brutal incident" and suspected the separatist Free Papua Movement (OPM) was behind the shootings.
Andi Widjajanto, a security analyst from the University of Indonesia, said: "This is big number of deaths, especially as they were all soldiers. This has never happened before in Papua."
The first incident took place at 9.30am, when an armed group opened fire on a military post in Tingginambut village, killing one soldier and wounding another, Papua province military spokesman Jansen Simanjuntak said.
An hour later in Sinak, 60 kilometres away, attackers opened fire at nine soldiers walking to a nearby airport, killing seven.
"They were going to the airport to pick up packages containing communication devices. All of the soldiers were unarmed," Simanjuntak said.
Suyanto urged all parties to allow the police and military to carry out their mission in hunting down the perpetrators.


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No. 3 Ursinus Rolls To The Finals
Nov. 6, 2010
COLLEGEVILLE, PA - Host #3 Ursinus College scored four goals in the first half as the Bears downed visiting Washington College, 6-0, on Saturday afternoon at Eleanor Frost Snell Alumnae Field in the semifinal round of the Centennial Conference Field Hockey Tournament. Top seeded Ursinus (17-1) advances to Sunday's final against the winner of second seed Johns Hopkins and third seed Haverford. Fifth seeded Washington concludes it season at 9-10.
Alyssa Thren of Ursinus set up the first goal as she lofted a pass into the goal mouth and Jennifer Bayzick tapped it in to put Ursinus up 1-0 with 26:14 left in the first half. Thren made it 2-0 Bears when she dribbled through several Washington defenders and rocketed a shot into the lower left corner with 20:36 to go in the opening half. Michelle Wimmer pushed the lead to 3-0 when she connected on a feed from Taylor Weidensaul. Corinne Freeman scored the final goal of the half on a loose ball in front of the cage.
Wimmer made it 5-0 with 24:49 left in the game when she converted on a penalty stroke. Wimmer scored the final goal of the game with 12:30 to go on a feed by Bayzick.
Wimmer had three goals to lead the Ursinus offense, while Thren, Bayzick and Freeman had a goal each. Thren, Bayzick and Weidensaul each had one assist. In goal, LauraLee Lightwood-Mater made one save.
For Washington, senior goalkeeper Shannon Davis (Sykesville, MD/Liberty) made 12 saves and allowed five goals, while freshman goalkeeper Steph Harryman (Churchton, MD/Southern) allowed the goal on the penalty stroke. Junior defender Brittany Palasik (Severna Park, MD/Archbishop Spalding) made four defensive saves to give her 33 for her career, a Centennial Conference record, and 25 for the season, an unofficial Division III record. Sophomore defender Erin Lewns (Fallston, MD/North Harford) tallied one defensive save.
Ursinus outshot Washington in the game by a 34-4 margin and had a 13-5 edge in penalty corners.
The Shorewomen competed in their sixth conference tournament in 2010 and have played in two of the prior three conference championships. The tournament began in 2000.


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I had a play around with a new website called We Tell Stories, set up by the UK publisher Penguin; it's a step into interactive fiction, and just won an award at South by Southwest, which I've only vaguely heard of, but apparently hands out awards for innovative websites. There are several of these interactive projects you can play around with on the website. One tells a story imposed over a google map of London, so that with each click on 'next' a line is drawn to another point on the map. There's another called 'Fairy Stories', where you get to fill in the name of the characters as you go along.
I'm all for innovation in fiction, but here's why We Tell Stories doesn't work, and why I don't expect the website to still be around in a year's time, if even that long. Fiction is a passive experience; the internet is an interactive experience. If you tell a story where you keep having to click 'next' just to watch a silly blue line scroll across a map, you lose your reader in five minutes flat, because it's a hell of a lot more 'immersive' to just read the damn story without any whistles and bells attached. That's why ereaders have proved so popular, despite their prohibitive cost and associated software/format problems; they come the closest to recreating the passive experience of reading an actual paper book. I don't want to have to come up with the names of characters for stories, because that's the writer's job, to draw me into a world of their creation. If I have to keep coming up with names, I'm going to get annoyed and bored. Which I did, by the way. Don't believe me? Next time you're in the pub and someone's telling a really good story, see if it's improved by them showing you a google map of where they went on that particular day. Er, no.
That's not to say I'm entirely against it. Like I say, innovation is a good thing, and experimenting is always worthwhile. However, as most scientists will tell you, most experiments provide 'fail' results. Where I can see some of these fiction models working is with very young children, where story-time is in fact a collaborative process between child and parent. I'd have loved something like this as a wee kid, and obviously slanted for my age. But 'We Tell Stories', I'm afraid, isn't it, and what particularly set alarm bells ringing was a Mr Hon's statement (according to the BBC report where I first learned of the site, anyway) that '"E-books are boring - they are just taking a manuscript and turning it into a PDF.'
Oh dear. And I suppose reading is a bit boring too, isn't it, Mr Hon? Here's the deal; if you need bells and whistles to persuade you to sit down and read a story, then frankly, nothing's going to make you want to read it. Not even that, er, great aid to reading, Google Maps.