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version 5.6
This new version of SeeSAR comprises another milestone in the evolution of our lightweight 3D modeling package, namely its ability to manage multiple protein structures simultaneously. Oftentimes, you may need to take account of multiple, related protein structures, perhaps either to identify the differences while aiming to achieve specificity, or – just the opposite – to find commonalities, such as when you are trying to ensure all variants of a protein will likely be inhibited. In this first implementation of the multi-protein feature, it is not yet possible to align protein structures but it is necessary to work with pre-aligned structures.
Loading multiple proteins
Loading a protein does not now start a new project, but instead the new protein is simply added to a table of loaded proteins. In order to visualize the binding of ligands from the protein file, first select the protein of interest and then select one of the ligands listed in the table. As before, any of these bound ligands can be copied to the molecules table with a click on the molecule icon in the ligand table row.
Handling multiple proteins
By default, the proteins chains are colored according to the same coloring scheme as before, with each chain in a different color. In the protein table you may set a unique color for a protein to ease identification that will be used for all components of that protein. If you edit a protein, the edited version of the protein will simply be appended to the table without overwriting the original. It is of course also possible to delete proteins from the table. Finally, you may choose the protein to be used for defining a common binding site from the table, just click the icon to start the binding site definition. Once a common binding site has been defined, a little binding site icon indicates which protein was used. Note that only this particular protein is used for the generation of poses, as well as for optimization and affinity estimation, i.e. the Hyde atom coloring on molecules is shown with respect to this protein.
Viewing multiple proteins
Once a common binding site has been defined on one protein, the binding site itself is shown in greater detail. Now however, the regions of the other proteins in the vicinity of the common binding site are also shown in greater detail. This allows you to see the detail you need when seeking out differences or commonalities but the view may, however, become a little crowded. An enhanced menu under the protein visualization icon allows you to switch on and off different protein components (secondary structure, binding site amino acids, ligands, waters and metals) individually or as a group, and you may also change the visibility of entire proteins at once, all making handling of the view very flexible depending on your needs.
Other improvements
We have fixed some seldom occurring but still irritating issues with the 3D editor and also implemented the possibility to restrict the number of CPUs that SeeSAR may recruit for its computation on the command line. On windows, check seesar.com --help to get an overview of all command line options. The option --thread-count allows you to limit the number of parallel compute threads as best suited. This feature is particularly useful if you run SeeSAR on a cluster which is controlled by a batch queuing system.
version 5.5
Shinier and speedier overall!
Besides a load of novel features (cf. below) behind the scenes, SeeSAR has been given quite a bit of a boost! You will notice a speedier start, faster response times and - most noticeable of all - real time scrolling even if you have loaded thousands of molecules in your table. Note that several of the new features require an update of the underlying databases and therefore
necessitate the re-calculation of Hyde scores
from older SeeSAR project files!
2D browsing featuring in-view molecule properties
To further enhance the 2D browsing, we have added an illustration of the molecules' key properties in the form of a radar plot. A thumbnail of the plot is embedded in each of the 2D molecule pictures, providing a quick overview. it enlarges upon mouse-over and provides access to the configuration dialog. Add or remove property-axes, optionally fine-tune the scales and set 'desired' value ranges. A hit or miss of the latter is indicated by green or red dots on the corners of the color-coded characteristic shape of the molecule on the plot (the greener the better).
Detecting novel/unoccupied binding sites
Now SeeSAR can search your protein for unoccupied pockets based on the world-renown
. You may then select these to become the binding site, within which to generate poses and calculate binding affinities for your molecules. The new binding site definition feature lets you either use a selected molecule from the table (based on a 6.5Å shell around it, as before) or will detect and visualize empty pockets for you to select instead.
Multiple reference molecules
The reference molecule in SeeSAR always stays in view even when you select other entries from the molecule tables. Now, however, you are able to set - and keep in view - as many reference molecules as you like. Either set them individually - in the selected molecule menu (as before) - or mark several as favorites and set them all as references at once, via the new menu button below the table.
Multiple core replacements with just one click
With the new multiple solutions button for ReCore in the molecule editor, brainstorming new scaffold ideas became yet easier. You can now generate 10 new alternative core replacements at once. The new molecules are saved directly to the table so that you can immediately see their estimated binding affinity and view all structures in 2D at a glance.
version 5.4
2D molecule browsing - time to look at things from a different angle!
While the molecule table offers great functionality for prioritizing compounds based on the data, it does not provide an overview of the molecules themselves. This release, however, sees the introduction of 2D molecule browsing. The table now offers two views - the one you already know and a 2D browser - flick between them using the switch below the table. Both views are always kept in sync so if you add a filter or sort etc. the 2D browser will show you the same result in the same order as the table. Also try expanding the table area to see how more molecules fit into the view.
Fantastic new 3D graphics features
This release also brings with it some great new 3D graphics improvements. As much as we all like visualising the binding site surface, it lay often times in the way… The binding site surface can now be switched to transparent allowing you to see through it and therefore making the analysis of the binding site and molecules within much more comfortable. Also, the feeling of depth in the 3D view has been improved to help orientation - a so-called "fog effect" fades out the protein and molecules that are further away to bring the foreground more into focus.
Persistent amino acid labels and better view of reference
So far, labels on binding site components unfortunately disappeared when browsing through different molecules in the table. Now amino acid, co-factor and water labels remain present if you change to a different molecule in the 3D view and even if you enter the molecule editor. The view of the reference compound has also been improved. For better visibility, the thickness of the bonds has been increased and instead of coloring the whole molecule in a uniform blue color, only the carbon atoms are colored blue so that hetero atoms can be distinguished more easily.
version 5.3
Think 2D in the 3D molecule editor!
The molecule currently visible in 3D is also shown in a 2D representation below. Now in the editor the 2D representation is actually interactive - if you hover to highlight or click to select in 2D, the same will happen simultaneously in 3D and vice versa, giving you a quick and simple overview of the bonds and atoms currently selected ready for editing. This is especially useful for selecting a core fragment (e.g. lasso-style!) for the ReCore scaffold replacement feature.
Tweak your molecule conformation by hand in the editor
Let's assume you made a major change to a molecule in the editor, for example by adding several atoms in a row, and the default positioning of the new fragment is not be optimal. Instead of finding yourself at a dead end, you can now adjust torsions in the editor: simply select a bond and then rotate either side of the bond to optimize the conformation within the context of the active site. While you rotate, the torsion coloring feature will guide you to avoid statistically unlikely states.
Key information from a PDB file at hand
The PDB header contains a lot of unstructured / free text information. The items deemed of most importance are now extracted and shown in the lower part of the protein table tab. In a brief overview, you will find useful information such as the DOI, resolution, and a list of the components along with links to the primary data sources.
SeeSAR has a new, more flexible licensing scheme
Previously, licenses for SeeSAR were issued with a fixed computer processor ID. Now server licenses are also available, meaning users can use SeeSAR from any computer that has access to the license server and are no longer restricted to working on the computer with the licensed processor ID.
Text label visibility improved
You will no longer lose your text labels and 2D molecule representation if you change your background color to white (useful for presentations via LCD-projector)! If the chosen background color is brighter than a certain threshold, the color of the labels and 2D picture now switches automatically to maintain good contrast.
version 5.2
Discover the next ReCore features integrated into SeeSAR
ReCore now takes the binding site into consideration when selecting new core fragments. Clashing as well as duplicate fragments are eliminated so that you will always see fresh ideas in the list. The new installation dialog offers you much more flexibility for installing a ReCore index file. It lets you download index packages from a dedicated website or load your own ReCore index file from disk. You trigger the installation either from the ReCore menu in the editor or via the Settings in the menu bar.
Simplify binding mode visualization
Sometimes the 3D view of the binding mode can be quite busy. Especially if you are preparing a picture for publication or other reporting it is desirable to focus on the essential parts. Now you can fine tune which components of the binding site are shown in the 3D view with just a couple of clicks using the new sequence dialog in the visualization panel (top center). Note that this dialog is available only if a binding site has been selected for the molecule table. If you have calculated the estimated affinity already, you can show H-bonded residues with just one click.
Color coded protein surface
This feature has been requested by many users and becomes reality with the new version. By default the surface is uni-colored but with a gradient according to the depth of the pocket. Alternatively you may select coloring by element or coloring by hydrophilicity based on the atom-specific logP values used for the Hyde affinity assessment (yellow means hydrophobic and blue the level of hydrophilicity).
Other improvements
Now also the 2D picture of the currently edited molecule is available.
Some use-cases require hiding or eliminating all unwanted molecules at once. To this end we enhanced the favorites filter to also filter the 'non-favorites'. So you can select all favorites => then hide them all => and delete all others.
Another minor annoyance was that the not-scored molecules always stayed in the way. Now if you filter to see only those compounds with an estimated affinity above a threshold we automatically filter out also all the not-scored compounds.
version 5.1
Now it's simple to rename your molecules
Double-click on the molecule to type in a new name - this is particularly useful for renaming the results of molecule editing.
Access your files and recent downloads more easily with the centralized loader
Molecule annotation now only one click away
The molecule annotation is now directly accessible with one click on the triangle mark to the left of the table rows. Mouse-over shows you your annotations while a click opens a small editor to edit them.
Core replacement preview
Many of you will already know our award winning software
. This release includes a sneak preview of the upcoming ReCore integration into SeeSAR. As this is only a preview release, you will need to carry out a few steps of preparation in order to discover its benefits:
and save it to the folder or directory where SeeSAR is installed.
Unzip the package into the same folder.
In the editor, you can see the new ReCore button in the menu. Once you have selected a core fragment in your molecule - it must have 2, 3 or 4 non-ring bonds to other fragments - the button will become active and you can click it. One click shows you the best geometrically fitting fragment from the library, another click will show you the next and so on. You can find more details about the sneak preview feature
version 5.0
This new version brings together several new features designed to give you more control over how you interact with SeeSAR and to speed up browsing in 3D. This means that a new project version is necessary - but here you may find the new project recovery feature useful! Major new features include the new protein ligands, molecules and editor tables plus the editor itself has seen great improvements in user friendliness. Finally, don't miss the new editor feature for editing covalently bound molecules.
Neater molecule management with the new protein and molecules tabs
The molecules table has now been given its own tab and is complemented by a new protein tab. This currently contains the protein ligands table showing the ligands loaded from your PDB file, while the table in the molecules tab is the molecules table you are already familiar with - having all the features previously found in SeeSAR such as filtering, calculating binding affinity with Hyde, pose generation etc. The editor has also been given its own fully interactive table to show the results of your last edits. Read more in the description of the new editor features below.
Edit, browse, and edit again - and even edit covalently bound ligands
As promised we have now added more features for covalently bound ligands. In SeeSAR 5.0 you can edit covalently bounds ligands just like any other molecule or ligand. First add your ligand to the molecules table and then you can select it for editing. Once you are working in the editor, you can take the time to view the results of your edits complete with Hyde atom coloring in 3D. To go back to editing, simply click continue on the edit menu.
A new binding site definition for comparability and speed
While the tables in the two tabs have the same look and feel, there are some slight differences. The protein ligands table shows you the binding affinity for all ligands in their binding sites as loaded from the PDB. However, to calculate the binding affinity or generate poses for molecules in the molecules table, you must first define a unique binding site. This binding site will be used for all molecules in the table, making the comparison of molecules that lie within the binding site more accurate - with the added bonus of greatly accelerating browsing in 3D. Currently the binding site can be defined really simply by choosing any molecule in either table as a starting point. The binding site then remains valid for all molecules in the molecules table until you decide to change your definition. The new binding site definition means that the estimated binding affinities calculated with the previous version of SeeSAR will now be incompatible with the new version and so they must be re-calculated. But SeeSAR can help you recover older projects - read on to find out more!
Recover projects saved with the previous SeeSAR version
A major release includes major changes that mean older projects can no longer be loaded exactly as they were. However, SeeSAR now has new project recovery feature which will load as much data as possible from projects created with the previous version of SeeSAR. Any missing data can then be re-calculated with just a couple of clicks.
version 4.2
Control of Hyde affinity calculations handed to user
Until now, SeeSAR automatically triggered the Hyde affinity calculations. This could be a long process, particularly when loading a large set of molecules from file, or after making an alteration in the Protein Definition dialog. Now, control is handed over to you the user to decide when the calculation should be triggered. This means large sets of molecules can now be loaded, analyzed and processed (e.g. filtering, calculating properties) before the intensive affinity calculations are run. You can trigger the affinity calculations just for a selection of molecules, for example, or even just for individual molecules in the Molecules table.
Enhanced filter features
The collapse and expand buttons (formerly found below the Molecules table) have now been transformed into a filter feature. This feature groups together identical molecules (identified by their unique SMILES), leaving just the molecule with the best estimated affinity as the representative - which is what was previously described as 'collapsing' and was triggered using the collapse button. Also, previously the collapsing or grouping action was always applied before the filters - which was not made apparent with the buttons. Now, this filter is always the last applied. This is clear as the filter is always to the last one shown in the filter panel.
Other improvements
On Windows, there was no output from SeeSAR when using the commandline interface - using the commandline on Windows was like flying blind! Just start 'seesar' on the commandline rather than 'seesar.exe' and the problem will be fixed. 'seesar --help' will give you more help getting started.
You can also export the protein ligands when using the commandline interface with the new option '--score-protein-ligands'. This is particularly useful if you need to analyse many protein-ligand complexes.
Covalently bound ligands are now optimized during the Hyde affinity calculation. This allows for a more reliable estimated affinity and is consistent with the treatment of all other molecules. Watch out for more covalent ligand features in following versions!
Finally, you may now load SD files of molecules into SeeSAR that contain many SD properties. SeeSAR will load the properties up to a maximum amount, whereas previously it was not able to load these files at all.
version 4.1
User-defined visualization settings
Up until now, the 3D view settings were optimized for the current scenario, i.e. when you loaded a protein from file or project it was shown in overview, while after selecting a molecule, the view was focused in more detail on the binding site, ... This was quite comfortable - particularly for first-time users - but at the same time limited your freedom to choose your own viewing preferences. As of version 4.1, the user is back in charge. The optimized settings are still shown to start with but now you can choose to show or hide the following:
• Hyde coloring for the selected molecule
• torsion coloring for the selected molecule
• whole protein
• surface for the binding site of the selected molecule
• unoccupied space in the binding site of the selected molecule
• all waters in the binding site of the selected molecule
The controls can be found in a panel above the 3D view on the main tool bar. There were previously some switches scattered about in different places in SeeSAR to control some of the these view settings - these have now disappeared having been replaced by the cleaner, less cluttered interface in the new panel.
Annotating molecules
Many users have requested the option to add comments to specific molecules. We have now implemented this as a new feature that can be accessed via the notepad icon for the currently selected molecule in the table. A sticky note is opened where you can enter your comments for this molecule as free-form text. The annotations are saved along with the user name of the author. Molecules with annotations are indicated in the table by a yellow marker at the top left of the row in the molecule table. If you move the mouse over the marker, the annotation appears as a tool tip making it easy to quickly scan through all the notes in the table. These notes are saved to the project allowing you to keep your ideas and thoughts for later, or also to share them with others.
Enhanced project handling
As of version 4.1, SeeSAR will now remind you to save your project if you have unsaved changes before you close SeeSAR or start a new project (either by choosing "New" or "Load" from the Project menu). You now also have the option to "Export" the raw data from your current project to a folder or directory of your choice. This will include the PDB file for the protein, all loaded molecules and any molecules you created using the editor.
version 4.0
Major release
This update of SeeSAR qualifies as major release 4, as several milestones have been achieved with it - namely the integration of the world-reknowned ADME property calculator from Optibrium ™, the display of the protein surface in the 3D view, and an update of the Hyde scoring function. Collectively, these changes have made an update of the SeeSAR storage mechanism necessary, so unfortunately old project files cannot be loaded with this version. We recommend you save your molecules from old projects to file and re-read them with this new SeeSAR version. As an additional bonus feature we implemented the multi-selection of favorites with a simple [Shift] and click. Just try it out, it works as you would expect.
As of version 4.0, SeeSAR is equipped with an interface that allows you to benefit from Optibrium's ADME property calculator from within SeeSAR. Any molecule loaded or edited is passed on to the property calculator, which itself applies multiple computational models to determine a variety of ADME properties. By default you'll see:
• logP
• logD @ pH7.4
• logS (thermodynamic, intrinsic aqueous solubility)
• logS @ pH7.4 (in phosphate buffered solution)
• Blood-brain barrier penetration (log([blood]:[brain])
• hERG inhibition (pIC50)
• CYP2C9 affinity (pKi)
• Human intestinal absorption (HIA) classification
• Blood-brain barrier penetration classification
• CYP2D6 affinity (pKi) classification
• Plasma-protein binding classification
• P-gp transport classification
However, if you have additional models (within the Optibrium framework) you can add those too and have the respective values available at your fingertips. Note that the usage of this feature requires a separate license!
Protein surface
The binding site of a protein is oftentimes quite complex making it easy to lose the sense of depth, space and tightness of fit. The protein surface of the binding site is now available to aid with orientation and can be toggled on and off very simply using a switch underneath the molecules table. This way, it is easy to switch between the surface view to find the orientation when you need to and the atom-only view at other times.
HYDE update
Hyde is quite sensitive with regards to the numerical stability of the calculation, which we have significantly improved with this update. We also detected a small inaccuracy in the way the coverage of interactions is calculated which has now been corrected. Overall Hyde now has a higher hit rate with respect to the experimental data for high-quality structures and on average avoids overestimating the affinities, i.e. it now provides a more conservative estimate thereby reducing the rate of false positives.
version 3.3
Considering individual water molecules (
watch this
One of the particular strengths of the Hyde scoring function (and therefore SeeSAR) is its estimation of the effect of water. The whole concept of Hyde is based on the balance of desolvation and interaction. However, as always, the exception defines the rule: Namely, what is true on average for bulk water may be different for individual water molecules. For this reason, Hyde by default explicitly considers water molecules that are particularly tightly bound. Of course, the default may sometimes miss a water that is of particular interest, or take too many into account by including a water that might not be all that stable. Therefore, we have enhanced the Protein Definition dialog so that the user can now have the final say on which waters should be considered and which should be ignored.
Assessing covalently bound ligands (
watch this
Hyde is much liked for its visualization of the individual atom contributions to the overall binding affinity. This version also allows such visual assessment of covalently bound ligands. They are now listed in the Molecules table together with reversibly bound ligands and co-factors. As with all the other small molecules, a focussed view showing the individual atom contributions to binding is shown in 3D when the covalently bound ligand is selected in the table. We don't, however, provide an overall binding affinity for covalently bound ligands since it is meaningless in this context. Editing of covalently bound ligands is currently disabled but is planned as a feature for a later version.
version 3.2
Utilizing SeeSAR without a protein
SeeSAR has grown from a single purpose affinity assessment tool to a multi purpose 3D structural viewer for compound design and prioritization. With this update it is now also possible to use all these nice features for 3D ligand-based projects. You may, for example, visually inspect small molecules alignments. You may filter a hit list by means of calculated and external properties...
Big data booster
With version 3.0 we first equipped SeeSAR with database functionality. Version 3.2 comes with a load of performance enhancements that speed up the calculation by up to a factor of 5, now utilizing all available CPUs in your computer even more efficiently.
3D graphics enhancement
In this version we updated the graphics support and SeeSAR is now compatible with more graphics cards than ever before. Especially the compatibility with integrated graphics cards (the type most frequently found in laptop computers) - which used to be the major trouble makers - has been greatly improved.
version 3.1
Working with "big data"
With this update we lifted the limit of handling only a maximum of 5000 poses in SeeSAR. We know that a lot of people like to do their compound analysis and prioritization after virtual screening campaigns also with much bigger sets. It is not likely that you will look at more than a couple of hundred poses, however, since the filtering (see also below) is extremely efficient, it provides quite an attractive opportunity to load all your data (not just the top x) and do your prioritization with all properties at hand right here in SeeSAR.
Enhanced filtering
Behind the scenes SeeSAR knows so much more about your compounds than what is displayed in the table. The basic stuff like no. of acceptors and donors, rotatable bonds, etc. to do the usual Lipinski-type filtering is of course available, but also more elaborate stuff like the number of hydrogen bonds formed or the number of torsions that lie outside the statistical "norm". All of these are now available for filtering to help you optimally trim down your data to find the really interesting part.
Older project files invalid
Please NOTE: SeeSAR project files from older versions are incompatible and cannot be loaded. By default SeeSAR puts a new version in a separate location. So your old version should still be there. If you happen to have lost the old version,
read here what you can do about it
version 3.0
Major release
This update of SeeSAR qualifies as major release 3, since it covers two milestones in its development. So far every SeeSAR session has started from scratch. The only way to retain molecules was to save them to file and re-load them again in a subsequent session. Needless to say that loading meant recalculating all Hyde scores again...
Project files
Starting with Version 3.0, SeeSAR allows you to store all session data in a project file. This includes the protein, ligands loaded from file and new (edited) ligands. Resuming your work on a project is now as easy as double-clicking on the project file. As a result, everything just got a hell of a lot faster! Whilst calculating Hyde-scores for say 1000 compounds took around half an hour (depending on your hardware), loading the same information from a project file now takes only a few seconds. Note that you can also generate a project file on the command line, allowing you to outsource the calculation of Hyde-scores to a different machine. This enhancement is also a great way to exchange data and ideas with a colleague! Simply store your SeeSAR session as a project file in a commonly accessible location (e.g. a network drive). Your colleague can take a look with just a double-click.
Hyde update
Hyde is quite sensitive with regards to the precise geometry of a binding pose. Even the tiniest difference in a pose can distort an anyway stretched hydrogen bond just so much that it is not recognized anymore - thereby leaving you with a huge desolvation penalty for such atoms, without the gain from the H-bond. This 'sharpness' of Hyde is its greatest strength (for example by highlighting real activity cliffs), but also its greatest weakness (especially if the structure has flaws or is of low resolution). In order to minimize such troubles, we optimize each pose before the Hyde affinity assessment. We improved this optimization significantly. It is now fully flexible and with sharper clash criteria, making it suitable for docked poses as well as edited compounds. All of this as efficient as before, just perfect for interactive use.
version 2.2
Solution filter
Finding interesting solutions in larger sets of compounds has just become much easier in SeeSAR. Compounds can now be filtered based on any available property - allowing you to easily trim down the compound set to the most interesting fraction.
As before, you can browse through and sort the remaining table entries to further refine your selection. Properties can be those generated by SeeSAR (such as the Hyde affinity assessment, the torsional strain, TPSA, logP, ...) or alternatively properties loaded from an SD file.
Joined poses
We have joined the ligands found in the protein structure, compounds loaded from file and compounds newly generated within the SeeSAR editor into one 'super' table and now provide quick-links to the previous view of only those from a certain origin. This allows you to see in one table the bound ligand as a reference, the project compounds and your last round of designs. You can then select your favorites from the entire table and export these (for example for an upcoming team meeting).
version 2.1
Defining the protein
SeeSAR decomposes the contents of a PDB file into chains, small molecules, waters and ions. Until now, users had to accept SeeSAR's default assignments, which is fine in the majority of cases. However, there is no rule without exception, e.g., the peptide inhibitor which is mistaken as a short chain, the small molecule which is actually a co-factor, or the solvent molecule that should be ignored. With this update, SeeSAR allows you to change these default assignments to better handle these exceptional cases, allowing you to categorize a short chain as a bound ligand, or re-assign a co-factor as a permanent part of the protein. You can also eliminate protein elements altogether.
SMILES, PDB and MOL file support
We equipped SeeSAR with additional molecule readers that broaden the scope of the application. Aside from standard 3D molecule file formats (SDF and mol2), SeeSAR now supports 1D and 2D file formats as well as reading small molecules from PDB format. If no 3D coordinates are given, SeeSAR will calculate a clash-free, low energy conformation on the fly: with the SeeSAR positioning function you can then place such input molecules in the active site of interest. Amongst other things, this feature facilitates the importing of molecules straight from your favourite chemical drawing program and assessing such structures in in the context of your protein of interest.
version 2.0
Major release
This update of SeeSAR qualifies as a major release, since it covers a milestone in its development. So far SeeSAR was able to assess given poses of small molecules in a protein structure. Starting with release 2.0 SeeSAR can also generate poses. Also note that the Hyde affinity assessment behind the scenes has been further improved by a variety of fixes and small changes for the benefit of more stability of the calculations. These changes will have an effect on the computed scores. If you rely on the scores resulting from a specific version of the tool, we recommend you to keep such older versions of the tool in an archive.
Pose generation
SeeSAR assesses the binding affinity based on the given position of the ligand in the active site. New in major release number 2 is the introduction of ligand pose generation directly within SeeSAR. So now you can draw and save a molecule in 2D, load it and have SeeSAR predict both binding poses and the related affinity for those poses. Similarly, if you make a substantial modification to the ligand in the editor, you can now validate the original position by generating new binding poses followed by the affinity assessment.
Ring conformation sampling
Significant conformational changes occasionally occurred when ring atoms were modified, reducing confidence in the Hyde estimated binding affinity. We have overcome this by implementing a conformational sampling of ring systems to identify the closest of all energetically favorable ring-conformations.
Stay focused
Sometimes, the 'big picture' can get lost while browsing and inspecting poses in 3D - users can now reset to a standard orientation by hitting 'Space' on the keyboard or with a click on the center view button in the utilities area (lower right corner in the 3D view).
version 1.6
Improved editing
One key functionality that was missing from our molecule editor was the ability to manually set atomic charges. We trusted the compute engine underneath (ProToss) to identify the most likely state automatically when optimizing the overall hydrogen bonding network. However, there are always exceptional cases that prove the rule. Now the user has the final say in this by being able to set the charge for individual atoms. Also, within the scope of the application the user setting won't be overwritten. Hotkeys '+' and '-' make these changes happen really quickly.
Improved table handling
a picture says a thousand words... To quickly eyeball a compound of interest in a SeeSAR table we implemented a feature to show the structure upon mouse-over.
Picomolar affinity:
one of the main applications of SeeSAR is in lead optimization where it is not uncommon to work with extremely potent molecules. These are now better accommodated by an extension of the estimated affinities into the picomolar range.
Pose-specific functions close by:
your mouse used to travel a fairly long distance from selecting a compound to the bottom of table to either edit, delete or keep a table entry in view. Now, these buttons appear just underneath the selected row.
Show/hide multiple table columns:
The context menu to add and remove table headers now stays in view for multiple selections and disappears gracefully if you click on anything else in the application.
version 1.5
More convenient structure editing
In order to make structure editing an even more convenient, swift and fun process, we have added a few new features:
simply select an atom, then type N to change it to a nitrogen. Obviously this "element change" shortcut works for all one-letter types (C, O, N, S, P, I).
simply right-click an atom (or bond) to get the all options to add a new atom (or change the bond type) right there.
Draw bonds:
simply click & hold on an atom, then drag to a second atom to connect the two with a new bond.
Improved table handling
After a virtual screen or docking run, many users will load multiple poses of each of their molecules and then interactively undertake the crucial steps of visual validation and selection. We improved SeeSAR in this regard with two new features.
For a better overview, you can now collapse all poses of one molecule to a single, representative table entry. This will be the best Hyde-scoring pose. Obviously you can also reverse this process and expand the table to show all the poses.
As you go through the table you can mark the poses as favorites that you would like to keep. Following this, you can then choose to export only your favorites.
version 1.4
Stereo Graphics
One of the top features on the wish list was stereo support for polarization hardware. So here it is! To activate stereo mode simply open the settings dialog and check the box for stereo view under Display. You can make adjustments for your eye distance using the slider too. If you use different stereo hardware, please let us know at
UX Further Improved
We have taken time to add some more enhanced user experience (UX) features. The main features are:
Re-position labels: Labels (activate this feature using the label icon in the utilities box, bottom right) provide useful information when you click on objects in the 3D view. Now you may drag labels to a different location. This is handy for preparing images to include in presentations and for de-cluttering your view.
Browse ligand table contents without leaving the 3D view: Jump from pose to pose with just a keystroke. Simply use the up/down arrow keys on your keyboard. You can even use the delete key, but watch out as there is no undo yet!
Screenshots made easy
A neat new convenience feature has been added to this version. Simply click on the camera icon in the utilities box (bottom right) and save your picture.
version 1.3
2D visualization of selected ligands
When things get complicated in 3D, it may help to drop a dimension: You can now check the 2D formula of a ligand at the bottom left - Prerequisite: the ligand must have been selected with a click on the respective table line. If you would still like to exploit the full 3D view, just hover over the 2D sketch and a collapse icon will appear for your convenience. Please note that during editing, the 2D picture will only be updated upon leaving the editor (shortcut: just press ESC to leave the editor).
Work with your own SD properties
Sort, check, visually correlate your own information stored in the SD files you use: Upon loading ligands via the menu entry (the 'L' icon in the upper left), we parse your information and you can add it to the properties table on demand. Additional SD properties are added by selecting them from the property drop-down icon at the far right of the table header. A mouse-over on the table column headers will display your property's full name. So, if you had, for example, your own favorite solubility predictor write its prediction into the SD file, you will now have the value ready to use in the table.
Web settings to comply with corporate environment
Your corporate security rules may force you to access the internet through a dedicated computer. You can now specify a proxy to make sure SeeSAR remains fully operational. Please note that the information about the latest updates (displayed when you click on Updates in the Information menu - '?' icon) is obtained from our webpage. If you can't access this information, this may be a hint that you need to change your proxy access settings.
version 1.2
See torsions color-coded by statistical relevance
We now color rotatable bonds in a simple traffic light scheme to show you whether your torsion angles are similar to those observed in crystals or not. Please note that
this is not an energetic statement
but rather a statistical one. You can switch between this view and Hyde coloring by using the toggle switch at the bottom left of the table. The colors have the following meaning:
red = seldom,
yellow = occasional,
green = frequent
Show receptor atoms contributing to a Hyde score
In SeeSAR, the contributions of receptor atoms are projected onto the ligand atoms, i.e. a red ligand atom can be red because a protein atom is 'unhappy'. To find out which receptor atoms contribute to the ligand atom Hyde score, switch on the label for the respective ligand atom using the label functionality in the utilities area (lower right corner in the 3D view), and click on the eye icon to highlight the contributing receptor atoms.
Quick, convenient distance measurements
To speed up measuring several distances from one given atom, you can now view distances with mouseover. Switch on the distance measurement mode using the utilities area (lower right corner in the 3D view), select an atom, and distances to other atoms will appear upon mouseover. If you click on a second atom, the distance measurement will be kept visible permanently.
Lipophilic Ligand Efficiency (LLE) - a new property
We have implemented an approximate LLE as an additional guideline property in the tables. The orientation of the thumb symbol indicates whether the LLE is great, good, fair, mediocre, or poor. The calculation is based on the Hyde estimated binding affinity and atomic logP values. The traditional Ligand Efficiency (LE) is still available; you can toggle both properties on/off (just as for all other properties) by using the selection tool at the far right of the table header.
File dialogs now remember your last location
When you load protein or ligand data, your last chosen directories will be remembered.
License expiration alert
5 days before your license runs out, an alert dialog will appear when you start SeeSAR. Contact us for an extension at
New version alert
When a new version becomes available, SeeSAR will show an alert on the information symbol in the toolbar above right. Click the 'Updates' icon in the information menu to see the new version details. Click on 'Download', or simply go to
, and download your new copy from there.
version 1.1
Conformers color-coded according to crystal torsions
For every molecule in a table, a traffic light style flag is now shown. This gives you a feeling for your ligand torsional conformation based on a comparison of the torsions in your molecule with respect to those observed in crystals. Please note that
this is not based on energies
but on statistical significance. In other words: The more frequently your torsions match those observed in crystals, the more likely the flag will say 'OK.' This is what the color-coding means:
green = most torsions are observed frequently,
yellow = some torsions are seldom or occasionally observed,
red = several torsions are only seldom observed
Visualize the 'explorable volume' of your complex
We implemented a swift visualization of where the tightness of fit can be improved, or where you can avoid the horror vacui in your binding site: While you are in 3D edit mode, white 'fog' will indicate empty space in the binding interface.
Multi-file loading
You can now load multiple ligand input files at once by performing a multi-selection using the Ctrl/Shift/Apple keys.
Unified labeling
Instead of separate labels for Hyde score, atom names, etc., we have now consolidated all this information in a single label per atom. To activate the label, use the label icon in the utilities area in the lower right corner, and click on an atom.
Drag and drop license files
License files (*.lic) received from us can be drag and dropped into a dialog opened from the information menu in the toolbar: Information >> License. This way, licensing SeeSAR becomes child's play!
what's new?
stay tuned with all the breaking news.
download & license
legal notice
privacy protection
© 2017 BioSolveIT GmbH, all rights reserved


text: Divxturka.net is using Redbunker! Because Redbunker is better than Hotfile, Netload and Rapidshare ! Click here and buy REDBUNKER premium account! Plot: When four friends head to the city for a Girl's Night Out, an unexpected ride home turns into a night of murder and terror as they are stalked by three serial killers through the dense Australian hinterlands. Genre: Horror IMDB rating: 5.0/10 from 160 users Directed by: Chris Sun Starring: Christian Radford, Shaun Trainer, Alexis Fernandez Release Name: Come.And.Get.Me.2011.DVDRip.x264-NoGrP Size: 729 MB Video: MKV | 720×404 Audio: English | AAC Runtime: 1h 30mn Information: Code: http://www.imdb.com/title/tt1826635/ Download: Code: Single Link No Extraction http://www.redbunker.net/s6cmkqaj2m0u/come.and.get.me.mkv.html Enjoy!

subset: commoncrawl


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Haglofs Schist Soft Shell Pants (For Men)
Item #5740X
About Haglofs Schist Soft Shell Pants (For Men)
Closeouts. Haglofs' Schist soft shell pants are designed for adventure with their technical design, nylon-spandex blended fabric and highly abrasion- and water-resistant DWR finish.
- The largest supplier of outdoor equipment in Scandinavia, Haglofs clothing and gear is thoughtfully designed and first rate in every detail
- Durable Water Repellent (DWR) finish is highly abrasion and water resistant
- Durable nylon construction with spandex for stretch and improved mobility
- Articulated knees allow greater range of motion
- Zip fly with dual-snap closure waist and integrated webbing belt
- Mesh-lined zip hand pockets
- Zip rear pocket
- Mesh-lined zip thigh pocket
- Offset inner leg seams at cuff for increased durability
- By Haglofs of Sweden
- Made in Viet Nam
- Visit our Pant Fit Guide
- Cannot ship to Europe, China, South Korea, Japan, Hong Kong and Taiwan
Specs about Haglofs Schist Soft Shell Pants (For Men)
- Features: Non-Insulated
- Closure: YKK®,Zipper
- Inseam: Short 31", Regular 32" (based on size large)
- Fabric: 90% nylon, 10% spandex
- Care: Machine wash/dry
- Weight: 1 lb.
- Made in Viet Nam
- Visit our Pant Fit Guide
- Cannot ship to Europe, China, South Korea, Japan, Hong Kong and Taiwan
Haglofs Mens Size Chart
|Tops - Chest
|Bottoms - Waist
|30.5 - 32
|32.5 - 33.5
|34.5 - 35
|38 - 38.5
|40 - 40.5
Note: Measurements are in inches.
Do you own this product? Write a review and help others with their buying decisions!
4.500000 5 Overall Rating: 4.5 Based on 10 reviews
Most Helpful 5-Star Review
Reviewed by JC from Falls Church, VA on Thursday, February 21, 2013
Ive been looking for a pair of pants that are similar to the fabric that schoeller uses in their dryskin line, and these pants seem to fit the bill. Im not sure if theyre wind resistant. They are like a lighter, slightly more thin fabric than in my pants with the schoeller 3xDry fabric. Nothing abou... Read More
Verified Buyer Reviewed by Hiker from Camino Santiago De Compostela on Saturday, November 14, 2015Extremely light material. Fits well, only, because I listened to previous reviews and ordered one size up. Thank you Sierra Trading Post for introducing me to Haglofs, great price good product.
Verified Buyer Reviewed by Genelief from Texas on Saturday, April 4, 2015The Haglofs Schist pants, size M, Reg, fit perfectly for a man 6'2" at 170 lbs, 32 waist x 34 inseam. Purchased for a comfortable "dress pant" for casual work. The seaming, construction, and fit are all flawless. Some pants made with this stretchy material pucker and pull, but these don't!
Verified Buyer Reviewed by Chinacat1951 from Ohio on Saturday, December 20, 2014I should have paid attention to the other review. Yes I am 6 foot tall and size 38. Yes I had to replace the large with an XXL. Also the inseam could fit an NBA player. But the pants are of good quality, are breathable - so winter use is questionable. So once I get the pants hemmed to shorten the length, Haglofs may be a good pair of hiking pants for the money.
Verified Buyer Reviewed by Anonymous from San Francisco on Sunday, November 9, 2014I have a similar pair of pants and use these for summer and winter hiking and climbing.
Great fabric because it is warm in windy conditions and breaths and cools in the heat.
A perfect 2nd skin for alpine activities.
Unfortunately, they were too big so I returned. The reinforced knee was a bit too much fabric but not a major issue.
Verified Buyer Reviewed by 0' to 5280' from Colorado on Friday, May 16, 2014I'm 6'2" 195lb waist size 34-36", inseam 33-34" depending on the cut of the pants. I ordered this pant in XL/Reg based on other reviewers and the fit was perfect. I also ordered the Haglofs Mid Fjell pant in XL/Reg . The material is a thin soft shell that should not be too hot for summer backpacking/camping trips as your night time or cool weather pant. I was planning on picking my favorite of the two styles and returning one but kept both due to the excellent fit and construction.
Question & Answer
Questions about this product? Get answers from community and staff experts.
According to the product specs above: •Inseam: Short 31", Regular 32" (based on size large)


text:
This tall cobalt blue shade hand-blown pendant is a great touch when you're out of design ideas.More Details >
Update your space in bright contemporary fashion with this brilliant cobalt cased glass mini pendant featuring a tall cone shade, plated finial, and an opal interior finish that maximizes reflectivity. Each decorative glass shade in this Juno Lighting low voltage pendant collection is individually hand-blown, so slight variations from piece to piece and an occasional minor blemish that reflects this creative spirit do occur. Also unavoidable is the satin nickel sparkle from each metal accent and detail of this Halogen fixture, including the monopoint canopy that houses an electronic transformer, the borosilicate white glass diffuser capsule, and even the generous length of coaxial cable for hanging.


text:
[This is a Japanese version]
[This is a Japanese version]
- Upgrade to membership period($2.00)
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プリンスに片想い - Japanese version
双子の姉の身代わりとして、ミシェル王子と結婚するためカラメール公国へ降り立ったキャロライン。 初恋の相手ミシェルに再会したキャロラインは、思いがけず彼の熱くセクシーな眼差しに心ときめいてしまう。 ミシェルは姉の婚約者なのよ・・・。 いけない恋と知りながら、高鳴る気持ちを抑えきれなくて!?
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|30 Pages
|129 Pages
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text: Flirting starts with not being attached to any outcome. You want to go into this with the mindset of having fun meeting someone new and interesting in the real world. And if it goes somewhere, great. If it doesn't, don't get discouraged. Instead, think of it as having had the opportunity to practice a new dating skill.


text:
Food For Kids
How can any child concentrate on education when they are hungry? Poverty causes many students to arrive at school Monday morning without adequate nourishment. Simply put, these children are hungry and in some cases have not eaten since Friday's school lunch. These circumstances create special needs and have dramatic effects on educational progress and self-esteem. Title One schools supply breakfast and lunch on school days… but who provides for them during the weekends?
Food For Kids is a Volunteer Center program that delivers non-perishable food to Title One elementary school children in the Carson, Compton, Long Beach, San Pedro, Torrance, and Wilmington school districts. The food is to be consumed over the weekend by these underserved families. Every Friday, Volunteer Center volunteers assemble and deliver shopping bags to the schools/students. Each bag is filled with ten (10) items of non-perishable food, for example: pasta, tuna, oatmeal, soup, applesauce, rice, beans, canned beef, peas and cereals. This provides food for the family for the weekend. Each family also receives one of five nutrition flyers provided by Providence Little Company of Mary Medical Center Torrance and the USDA.
Please help!
1. Donate
Each bag of food costs approximately $26.00. Donate to Food For Kids!
2. Join Pantry Partners
Click here to learn more about Pantry Partners, which provides food for South Bay children on weekends. We are looking for members with skills in these and other areas of building a community:
3. Donate Food
Review our list of appropriate food items and drop off your non-perishable food donations at our Torrance Food Pantry. We only accept food that has not passed its expiration date.
4. Support a Food Drive
There is a food drive for every type of organization. For a range of fun and productive ideas, please our Food Drive Tips and Tricks.
You are very welcome to come meet us or we can speak to your group. I do hope we can work together. What you do makes a difference to real children and is deeply appreciated by the children and their families. For more information about how else you can help please email us at firstname.lastname@example.com.
The real story: International Elementary School letter to the Volunteer Center
I just want to tell you how much this project has helped our families at International Elementary School. This has always been a needy area; however, in the twelve years I have been here there has never been such a high number of homeless families. There are actually so many families that are in need that we have found that we need to keep a spreadsheet so that we know who we have given to and that we rotate each week so that we can help as many families as we can. There is such desperate need that we are not helping as many families as we would like to.
Here are a few examples of the families your program touches:
Maricela is a parent that would always help the school with fund-raising, PTO meetings, you name it. This year, however, her life has changed. Her husband and father of three had a major stroke that left him paralyzed. Maricela who had never worked is now working to support her family. They had to move to an apartment that was less expensive and his mother had to move in to assist with daycare so Maricela could now work. The family has really been struggling financially not to mention the heartbreak of seeing him suffer.
Another story is our little Isaiah who comes in late everyday because he is homeless and sometimes has to travel further to get to school. He usually has not had breakfast and sometimes has not had dinner because they didn't get back to the shelter in time to eat dinner. We always have something for him to eat in the office because he cannot concentrate on school work when his belly is empty.
If you ever question whether your program actually helps, please know that without the food that your program provides a lot of families would go hungry. I only wish that we could help more but are so grateful that we could help any at all.
It is hard to tell some families that we cannot give them anything this week but maybe next week but we find we have to do that a lot these days as there are just so many that need help.
Again we would like to say thank you for all that you do and please tell your donators that they really do make a difference and without their generous donations all the little Isaiahs would go hungry and the families going through personal and financial struggles would find it even more difficult to put food on the table. Thank you again for all that you do.
Leticia Keller
Secretary/Office Manager
International Elementary School
To watch a short video of local media coverage of both the needs and the Food For Kids solution, please click the image below.
The Volunteer Center presents how Food For Kids is helping our community.
Long Beach Register April 28 2014 Webster Elementary School thanks Team 100 program for generous food donations
To read a another recent story in the Press Telegram, click here.
The children of Jefferson Elementary School thank the Food For Kids Program


text:
It is a really short story, so I can't really say much. It is basically about a woman in an insane asylum.
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Count. Count. Count. 10 fingers. 10 toes. 62 cracks in the wall.
I am rocking. Back and forth. Back and forth. He is gone. He is gone. He is gone. Dead. Dead. Dead.
One bed. One window. One chair. Count. Count. Count. That's all I do. All I can do.
"It's okay," they say.
"We will take care of you here," they say.
4 corners. 1 floor. 1 ceiling. All I see are brick walls. 4 walls. I stare. I want to scream. Everyone else screams. Why can't I? Why don't I?
I hear them. Every single one. Screaming. Scratching at the walls. Begging to get out. Why am I not like that? Why? Why? Why?
"This is the place for you," they say.
"People here are just like you," they say.
Insane. They call me that. Insane. Insane. Insane. Because I did it. Because I killed. Because I murdered. My love. My other half. My husband.
They tell me it's not my fault. I am in insane. I didn't know any better. I didn't know. Didn't know. Didn't know. Didn't know.
1. 2. 3. 4. 5. 6. 7. I wasn't insane. But I am now. I am because of this place. Not because of what I did.
They can never know. Never know that I lied. Never. Never. Never. Because I was fully aware. Because I knew exactly what I did.
I didn't do it because I was insane. I did it because I wanted to.


text:
Episode 3503
31,562pages onAdd New Page
this wiki
this wiki
|Sesame Street
|Linda's running record (repeat of 3248)
|Air date
|April 17, 1996
|Season 27 (1995-1996)
|This episode guide has been compiled from incomplete video material.
|Telly welcomes the viewer and says that today, Linda will try to break her record of running around the block non-stop 40 times. As she warms up, Telly and the kids warm up their hands for cheering and the Count, the official counter, practices counting. Linda is ready to go, so Telly and the kids cheer as she makes her away around the corner.
|The Count becomes impatient waiting for Linda to make her first lap, not realizing how long it would take. Telly points to the following segment to take his mind off counting...
|The Count enjoyed the segment, but still wishes he had something to count. Nathan suggests he count cheerleaders, a fine way to pass the time. When he finishes, Linda passes by, completing her first lap, which the Count counts. He then notices something else for him to count...
|Linda completes her tenth lap, when Telly notes that while she's getting plenty of exercise, he and the others aren't as active. The Count encourages them to dance along as he sings "The Transylvania Polka."
|Linda comes by on her 24th lap and gives everyone a sign, but Telly isn't sure what it means. He doesn't know how to sign asking its meaning either. The kids suggest he just write it down and they run off to get some materials.
|Linda comes by and reads their sign and acts out drinking to Telly, followed by pointing to the fire hydrant. Telly assumes she wants a drink from it, then realizes she wants some water. He and the kids rush off to get her (and the Count) some.
|Bob stops by and the Count informs him of Linda's mission. Telly notes that Linda may not break 40 laps, as she's been very tried the last few. Sure enough, Linda comes by, finishing her 40th lap and doesn't seem like she'll continue. Telly, Bob and the kids encourage her to keep trying and follow her cheering as she attempts another lap.
|The Count witnesses a taxi pulling up with the whole gang inside. Telly explains Linda got exhausted midway through and couldn't make it back, so Bob hailed them a taxi (being the only one who could afford cab fare). The Count notes that she made it 40-and-a-half laps, thereby beating her previous record! They're sure she can make it a full 41 tomorrow and cheer for her. The Count then announces the sponsors.
|Previous episode:
|Next episode:
|Episode 3502
|Episode 3504


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San Diego, CA -- (SBWIRE) -- 05/16/2012 -- A deadline is coming up on June 11, 2012 in the lawsuit filed for certain investors in NASDAQ:EFSC shares over alleged Securities Laws Violations of in connection with certain financial statements made by Enterprise Financial Services Corp.
Investors with a substantial investment in Enterprise Financial Services Corp. (NASDAQ:EFSC) shares between April 20, 2010 and January 25, 2012, should get active before the Deadline that is coming up on June 11, 2012 and should contact the Shareholders Foundation at mail(at)shareholdersfoundation.com or call +1(858) 779 - 1554.
According to the complaint filed in the U.S. District Court for the Eastern District of Missouri the plaintiff alleges on behalf of purchasers of Enterprise Financial Services Corp. (NASDAQ:EFSC) between April 20, 2010 and January 25, 2012, that Enterprise Financial Services Corp. and certain its executive officers violated the Securities Exchange Act of 1934 by issuing allegedly false and/or misleading statements and/or failing to disclose material adverse facts about Enterprise's business, operations and prospects.
On Thursday, January 25, 2012, Enterprise Financial Services Corp (Nasdaq: EFSC) announced that it will have to restate its financial statements for the year ended December 31, 2010 and for the first three quarters of 2011 and 2010. Enterprise Financial Services Corp said it discovered an accounting error that resulted in an inadvertent overstatement of income on loans covered by FDIC loss share agreements during those periods.
Enterprise Financial Services further stated that its Annual Report on Form 10-K for the year ended December 31, 2010 and the interim financial statements included in its Quarterly Reports on Form 10-Q for each of the periods ended March 31, June 30, and September 30, for 2010 and 2011, respectively, should no longer be relied upon.
Shares of Enterprise Financial Services Corp. (NASDAQ:EFSC) fell from $15.50 on Jan 25, 2012 to as low as $11.05 per share on April 10, 2012.
On May 15, 2012, NASDAQ: EFSC closed on $11.06 per share.
Those who purchased shares of Enterprise Financial Services Corp. (NASDAQ:EFSC) have certain options and should contact the Shareholders Foundation.
Shareholders Foundation, Inc.
Trevor Allen
3111 Camino Del Rio North - Suite 423
92108 San Diego
Phone: +1-(858)-779-1554
Fax: +1-(858)-605-5739


text:
The holidays are an exciting time for many children but can also be an overwhelming time for children with Attention Deficit Hyperactivity Disorder (ADHD). Here are some tips on how to handle the upcoming holiday season for parents and caregivers of children with ADHD.
The holidays are upon us and we couldn't be more excited! Yet, we know how hectic this time of year can be. Remember, tis' not the season to feel stressed. There are lots of ways to save time and money but still surprise and delight your family and friends.
As someone who loves to entertain for my family and friends, I know just how tiring hosting can be -- but who says it has to be this complicated? It's time to get back to basics and remind ourselves of what we love most about get-togethers during the holidays and year-round.
This celebration of a new beginning is something everyone can agree on - it's time to have some fun. These four Canadian destinations are places where you can celebrate 2017 in an unforgettable way.
During the holidays, the usual routines and motivations aren't the same and work tends to move at a slower pace. However, this doesn't mean you have to slow down, too. In fact, I find the time just before the holidays to be my most organized period. Below are some steps you can take to stay focused before the holidays and New Year approach.
Endorsed for their popular souks, these six cities are a great choice for travellers who want to escape the traditional Christmas shopping and explore some of the oldest markets in the world. You're sure to appreciate the lights of the suspended lanterns and the colourful stalls.
The holiday season means constant activities, festivities, shopping, gatherings, and of course, lots of food. This can be exciting for many, and daunting for others. Food should not be a source of stress or guilt during the holidays (or ever) and it's important to make time for self-care to stay healthy and to reduce stress.
Susan was a fellow office manager. She was given a budget to decorate for Christmas. As she transformed our offices with green and tinsel, she also loudly voiced what a waste of time and money it was. She even complained about the lunch-time Christmas party on Christmas Eve when we could leave early. Oh, for crying out loud!
The story of Santa Claus, his elves and the giving of gifts has graced our lives for hundreds of years. It is more than just the story of a jolly old man on a quest to give gifts to every child in the world. It's a lesson about generosity and kindness.
Almost half of all charitable donations occur over the holiday season. Charitable giving is something that is deeply personal, reflecting your values and life experience. But there are some practices that everyone can follow to give well.
It's party season! The happ, happiest season of all! Maybe you're hosting, or maybe you'll be doing a lot of "guesting" ... Regardless, of what your Yule tiding role will be, here is the alphabet to guide you on the twenty-six dos and don'ts of party etiquette.
The truth is that you don't have to be an expert host to leave a lasting impression on your guests, which is why I'm sharing my must-have entertaining essentials and pro tips to ensure you'll be ready to tackle anything the holidays might throw your way!
There are too many Christmases where the shine was dulled by illness. Several times, Christmas Day got completely postponed, and everyone stayed home to avoid more cross-contamination! So, what you do to get through the next few weeks if an unplanned bug shows up to mess up your plans?
Holiday gift giving can be really stressful, so now it's time to take a different approach. Let's take a step back this year and take a frugal appr...
As it turns out, not all holiday shoppers are cut from the same cloth. Some savour the bricks and mortar experience while others cringe at the thought of stepping foot into a shopping mall. And no matter what kind of shopper you are, there are plenty of great tips and gift ideas to be had for every kind of shopper out there.
For many people, weight gain during the holidays is a foregone conclusion. Resolutions to do better this time are largely destined for failure, no matter how seriously they are taken. In the end, the countless temptations offered at office parties and family gatherings prove as irresistible as always, obliterating all good intentions.


text:
Search by Keyword, Part Number, SKU, UPC
The PowerVerter MRV2012UL Inverter is the quiet alternative to gas generators -- with no fumes, fuel or noise to deal with!. This heavy-duty inverter with automatic line-to-battery transfer and integrated charging system serves as an extended-run UPS, a standalone power source or an automotive inverter suitable for rugged RV applications. Supplies up to 2000 watts of continuous 120V AC power from any 12V DC battery or automotive DC source. When hardwire AC input is energized, commercial power passes through to connected equipment and the battery set is recharged via 3-stage charging system with user-selectable 25/100 amp charger output. In UPS mode, the MRV APS system responds to blackouts and voltage fluctuations with a near-instantaneous automatic transfer to battery-derived AC output. Highly adaptable to a variety of applications and site conditions with adjustable charger settings for wet/gel battery types and selectable line to battery power transfer voltages.


text: At Remodeling Options Inc. we offer quality craftsmanship and full-service for all of your home remodeling needs. Our experienced staff from St Charles, IL are skilled and professional, providing our clients with excellent service and competitive pricing. Our expertise and years of experience allow us to offer exceptional services at fair prices. Tight budget? No problem!


text:
|incl. VAT
|excl. VAT
Bigjigs is an English company founded in 1985 , Who devoted his activity creating the most amazing toys of wood. Their main motto is customer satisfaction and uncompromising commitment to quality and originality of the materials used. Let yourself be enchanted by the most natural material and Get to know what it is - to play really well, play with wood.
Bigjigs Wooden puzzle not only bring proven quality brands, but also colorful and interesting motifs That stimulate your child's imagination. Just choose your child's favorite theme and the fun can begin. Puzzles are so popular activity, not only because children play with them will be fun, but also improve their motor and cognitive skills .
Thanks to these beautifully colored and perfectly molded puzzle in the shape of numbers You can easily your child a fun way to learn basic numbers. Easily learn to recognize the leader of sevens and all the other naughty numbers. Recommended for children from 3 years.
Specifications can be changed without notice. Images are for illustrative purposes only. Retail Price (MSRP) means the manufacturer's/supplier's suggested retail price.
Link to Manufacturer's Website: Enter link to the external review


text:
A family home: convenient, comfy, and designed for the whole family
Pleasant sea-side resort, famous for diving among others. Beautiful sand beaches that stretch for miles, splendid hiking trails along the mediterranean coast.
Cultural/Tourist Attractions, Children's Activities, Restaurants/Bars, Tennis, Outdoor Biking, Beach/Swimming, Boating/Sailing, Surfing/Windsurfing/Kitesurfing, Hiking
shipwreck diving (by night...)
To organize a home exchange, you need to be a member


text:
Sowing the seeds for a better future.
Deforestation is one of the biggest ongoing disasters facing the world today, and we're the ones to blame.
Whether for profit, land, or simply as a way to provide for one's family, forests across the world are being torn down at alarming rates. According to National Geographic, while forests cover approximately 30% of the Earth's surface, areas the size of Panama are lost each year, and if we continue at our current rate of deforestation, the world's rainforests could totally disappear within a hundred years.
The effects of deforestation are many and the impacts are felt by all, whether or not we know it. The majority of the world's plant and land animal species live in forests, and the loss of their habitat is a clear path to extinction. On the human end, deforestation prompts climate change by disrupting the water cycle, reducing the amount of oxygen in the atmosphere, and dangerously altering temperature patterns that forests typically help to moderate.
Simply reversing the devastating effects of deforestation may seem simple: plant more trees. Unfortunately, our current methods of reforestation largely include manually planting seeds, which is time-consuming, labor-intensive, and limited to the places that humans can easily access.
Now, a former NASA engineer and his company have a plan that would incorporate popular modern technology to start a green revolution on the planet.
He wants to use household technology to save the planet's forests…


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Paolo Ulian was born in the Italian Massa Carrara in 1961. During his apprenticeship he visited classes of arts from Getulio Alviani and Luciano Fabro at the Academy of Fine Arts in Carrara for three years.
Ulian also made his diploma in Carrara in 1990. In 1992 the Italian designer became independent together with his brother Guiseppe and he continues working with him successfully.
Paolo Ulians cooperation with Droog Design and some important Italian design companies started in 1995. In 2003 he designed his "Bowl" for FontanaArte, to be used as clothes hook or as shelf for objects.
Website by Paolo Ulian


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35-year-old Justin Jones was arraigned Tuesday afternoon for having 13 Percocet pills he didn't have a prescription for back on December 17. Police found the pills in a cigarette pack during a traffic stop for an expired registration after Jones consented to a search.
In the drug task force case, Jones is accused of selling Suboxone from his Hedgehog Lane home.
On the new charge, he's jailed on $10,000 bail.


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I've never been angry at San Antonio Spurs owner Peter Holt throughout this lockout. Business is business and his team lost some money the last couple of seasons so he's trying to do what's best for his business. While I can partially blame him his business losing money, I certainly can't be angry about these things.
But this I can be angry about. Turns out Peter Holt and Chris Paul may have gotten in to a bit of a dust up during a negotiating session last month. CBS Sports' Royce Young, quoting a New York Post story, reports CP3 didn't take too kindly to what perceived as a threat from Petey.
"According to a person involved in the process, the owners have played it wrong in challenging the players -- unless it is their intent not to have a deal. Which it may be. Last month, during the first federal mediation, Chris Paul got overheated when San Antonio owner Peter Holt said of their revenue-split 50-50 offer, 'Take it or leave it.' Paul shouted back several times: 'Take it or leave it?' The union left it."
Listen here Petey, you just crushed one young writer's dream. You pissed off the league's best point guard who's entering free agency next summer when you're guaranteed to have some cap space to go after him. But that was a long shot, a pipe dream. Here's what isn't. Paul obviously is fiery guy and probably doesn't forget stuff like this. So next season when the Spurs and Hornets play each other in the regular season and maybe the playoffs, I envision Paul dropping a triple-double on the Spurs then doing the DX crotch chop in Holt's general direction, hits with a steel chair and then walks off the court in victory.
Anyways, here's hoping the lockout gets solved today. Thanks for ruining my lunch, Peter!
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Holiday Inn Express Hotel & Suites ELKINS
Select your stay dates to check availability at Holiday Inn Express Hotel & Suites ELKINS
Holiday Inn Express Hotel & Suites ELKINS
About the Hotel
Property Location
Located in Elkins, Holiday Inn Express Hotel & Suites ELKINS is in a rural location and convenient to American Mountain Theater and Davis and Elkins College. This hotel is within close proximity of Augusta Heritage Center and Elkins City Park.
Make yourself at home in one of the 69 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wired and wireless Internet access keeps you connected, and cable programming provides entertainment. Conveniences include desks and complimentary newspapers, as well as phones with free local calls.
Be sure to enjoy recreational amenities including an indoor pool and a 24-hour fitness center.
A complimentary hot/cold buffet breakfast is served daily.
Business, Other Amenities
Featured amenities include complimentary high-speed (wired) Internet access, a 24-hour business center, and complimentary newspapers in the lobby. Planning an event in Elkins? This hotel has facilities measuring 1036 square feet (93 square meters), including a meeting room. Free self parking is available onsite.
Hotel Facilities
- Laundry facilities
- Elevator/lift
- In-room accessibility
- Free wired high-speed Internet
- 24-hour fitness facilities
- Free WiFi
- Total number of rooms - 69
- Accessible bathroom
- Indoor pool
- Conference space size (meters) - 93
- Number of buildings/towers - 1
- Smoke-free property
- Safe-deposit box at front desk
- Free newspapers in lobby
- Free self parking
- Roll-in shower
- Number of floors - 3
- 24-hour business center
- Free breakfast
- One meeting room
- Conference space size (feet) - 1036
Room Facilities
- Desk
- Air conditioning
- Phone
- Private bathroom
- Coffee/tea maker
- Premium TV channels
- Free local calls
- Hair dryer
- Rollaway/extra beds available
- Cable TV service
- Free wired high-speed Internet
- Refrigerator
- Microwave
- Iron/ironing board
- Daily housekeeping
- Free newspaper
- Free WiFi
- Free cribs/infant beds
- In-room climate control (air conditioning)


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£145,500 - £221,995
Pippin Wood is an exciting new development of exclusively private homes enjoying a prime location in the highly desirable community of Wellington, Shropshire, in the shade of the famous Wrekin.
off Holyhead Road - Wellington - Shropshire - TF6 5DT
Would you like to download a brochure or request a brochure by post?
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Call us 01952 455 784
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Artists Impression
Pippin Wood is an exciting new development of exclusively private homes enjoying a prime location in the highly desirable community of Wellington, Shropshire, in the shade of the famous Wrekin.
This wonderful collection of traditionally designed two, three and four-bedroom homes is situated on the edge of the leafy residential neighbourhood of Haygate with the stunning Shropshire countryside stretching away to the north, south and west.
The new homes are being provided alongside a state-of-the-art extra care facility from The Wrekin Housing Trust for over-55s. Set within landscaped grounds incorporating mature trees and green open spaces, Pippin Wood will provide a wealth of choice for first-time buyers, downsizers and growing families looking to settle down in green and pleasant surroundings.
Help to Buy available
2 bedroom
Terraced House
The Appleford is a 2 bedroom home offering convenient accommodation that's ideal for individuals or couples. At the heart of the home is a light and airy open plan kitchen/living/dining area which is perfect for entertaining and opens through French doors to the private rear garden.
New release
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New release
3 bedroom
Semi-detached house
First-time buyers and those stepping up the property ladder will find the 3 bedroom Earlsford has the space and style required to be their ideal home.
Ask us about Help to Buy
Show home for sale
Show home for sale. First-time buyers and those stepping up the property ladder will find the 3 bedroom Earlsford has the space and style required to be their ideal home.
Home of the week
3 bedroom
Detached house
The Ardingham at Pippin Wood is a 3 bedroom family home perfect for first time buyers or those stepping up the property ladder. Complete with flooring
Set within landscaped grounds incorporating mature trees and green open spaces, Pippin Wood provides a wealth of choice for first-time buyers, downsizers and growing families looking to settle down in green and pleasant surroundings.
Wellington is an ancient settlement which became established as a market town following the award of its Royal Charter in 1244, and it prospered as a result of the iron industry and coaching trade. Its rich history is celebrated every year with the ever-popular Midsummer Fayre.
Today, the thriving town centre boasts a variety of attractive historic buildings, bustling indoor and outdoor markets and a host of independent shops, traditional pubs, bars and well regarded eateries – as well as free parking.
Wellington also benefits from excellent transport connections, with the nearby railway station providing direct connections to Birmingham, Wolverhampton, Shrewsbury and mid-Wales, and the M54 and A5 within easy reach.
Parents will appreciate the close proximity of a number of schools for children of all ages, and there are plenty of opportunities to enjoy the great outdoors close by, with the Shropshire Hills right on the doorstep and the UNESCO World Heritage Site of Ironbridge Gorge one of the many attractions waiting to be explored in rural Shropshire.
Oakwood Extra Care Facility is now open
The new residential care facility at Pippin Wood is now open.
The Extra Care facility is managed by ShireLiving and comprises a total of 63 apartments, bringing much-needed care facilities to the area for the over 55's, offering 24-hour support to residents.
As well as individual private one and two-bedroom apartments, there is also a communal area for socialising and leisure activities, and an on-site restaurant with views of the Wrekin and local cricket ground.
Easymover is available here, which means you could reserve a new Taylor Wimpey home at this development - even if you haven't sold your existing property.
And that's not all. With easymover, we'll make your house move as stress free as possible. We'll liaise with your estate agent on your behalf, we'll pay their fees and we'll manage the whole house selling process - making your life so much easier! Take a look at our easymover page for more information.
Terms and conditions apply to the Easymover scheme.
Why not consider Part Exchanging your existing property for a brand new Taylor Wimpey home? With our Part Exchange scheme, you could move into a new Taylor Wimpey home without the hassle of selling your old one.
We'll buy your existing property at 100% of its market value. You'll avoid all the stress of putting your house on the market, managing and paying for estate agents, and worrying about house buying chains! Interested? Find out more about Part Exchange.
Terms and conditions apply to the Part Exchange scheme.
Looking for an armed forces discount? At this development, members of the armed forces could get a discount of up to £500 for every £25,000 spent on a new home. If you think you could be eligible, why not find out more about our armed forces discount today?
The Government backed Help to Buy scheme is available here. The scheme is open to both first time buyers and home movers alike, and means you'll need just 5% deposit to buy a new home.
With Help to Buy, the Government will lend you up to 20% of the value of your new build home via an equity loan. You will need to secure up to a 75% mortgage and put down a 5% deposit. You'll own 100% of your home from day one.
Help to Buy is also available in conjunction with our easymover scheme, which means we could help you sell your existing home and pay your estate agent fees. Find out more about how the Help to Buy scheme works.
This development is managed by the North Midlands Taylor Wimpey regional office


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Need a Measles Titer in Fortville, IN? Simply order online 24/7 and get a fast, affordable Measles Titer at a lab near you (Find More Locations):
Why would I get a Measles Titer?
The Measles Titer is a blood test used to prove immunity to Measles. People in Fortville, IN get the Measles Titer for general screening or for work or school compliance.
How much does a Measles Titer cost?
Our Measles Titer price includes the doctor's order that you need to get tested in Fortville, IN, all lab fees and taxes, and a pdf copy of your results. For current prices, CLICK HERE.
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For a sample report, please CLICK HERE.
We are delighted to offer the Measles Titer in Fortville, IN.
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News By Tag
Industry News
News By Place
Industry News
Custom Shoemaking & Repair Specialists Celebrate 5th Anniversary & Upscale Nationwide Customers
Shoe Service Plaza Co-owners in Bethel, Connecticut, two brothers from Ecuador, are celebrating five years of entrepreneurial success and their upscale clientele for their custom shoemaking, repair and restoration services for all leather products.
Having honed their shoemaking, repair and professional shoe shining skills under their shoemaking father's influential expertise in Ecuador's 'shoemaking capital' the town of Gualaceo, in 1988 Fausto Guamantari brought his expertise to the Empire State Building where he repaired shoes for wealthy people in Manhattan for five years. He then began repairing shoes at the widely-respected Jim's Shoe Repair on 59th Street, a business in existence for over 60 years. In 1993, Felipe Guamantari brought his Ecuadorian-trained skills to Manhattan's also well-regarded Leather Spa that employs 90 shoemakers and professional shoe shiners. Meticulously-
In June of 2014, the Guamantari brothers are celebrating five years of notable success. In 2008 they opened their first store at 78 Stony Hill Road in Bethel where they began offering custom shoemaking skills along with shoe repair, professional shoe shining, handbag restoration and many other services. In June 2013 they moved their operation from 78 to 68 Stony Hill Road and their business increased by 40%. "Drivers see us easily because our store is located in the front of the shopping plaza that also houses Mexican Rose Restaurant & Cantina, Aveda New Beginning Salon & Spa, Newtown Savings Bank and Toe Toe Nails. "This plaza attracts 300 to 400 people every weekday. Traffic on Thursdays and Fridays is even heavier," stated Felipe Guamantari., "We attract a lot of people sitting in traffic who are very happy to learn about our business and are very pleased with our services."
Fausto Guamantari added, "We have many customers across the country that find us online and just place orders from our website. A number of our loyal customers drive up from Connecticut'
Annually the brothers attend an international shoe convention, "to offer the best services to our customers." Fausto Guamantari explained, "We attend this expo to bring the very best materials and seasonal styles to our sophisticated customers. We learn about new fabrics, leathers, rubbers, polishes and better ways to maintain shoes. Plus we learn how to best serve our customers, improve our skills, and better machinery and equipment. Because of the 2013 summer convention in Mexico, this summer we'll be installing new machines that we saw at that convention. All to best serve our customers."
On June 5th, Shoe Service Plaza celebrated their fifth anniversary of success. In addition to creating hand-made, all-leather custom shoes and belts, and offering fast-service professional shoe repair, handbag restoration, and fabric shoe dyeing, the enterprising brothers now offer custom-made sandals. "Women really like our all-leather hand-made sandals because they can get exactly the style and color they want. This complements are dying capabilities for fabric shoes that women want for weddings, communions, graduations, and other special occasions," commented Fausto Guamantari.
"Our expertise," commented Felipe Guamantari, "is especially appreciated by people in, or formerly from, big cities. People who come from New York to our Bethel store are always delighted to see our big leather professional shoe shine chairs. We offer a 'lost art' and people are happy to experience expert shoe shines while sitting and reading a newspaper or magazine, or working on a computer."
Shoe Service Plaza's far-reaching reputation across the U.S. comes from their expert abilities to make and repair custom shoes, plus clean, dye, remove scratches and repair any quality leather product, plus expertly replace zippers, shoe soles, heels and tips. "We stock a complete line of leather care polishes, creams and laces, shoe trees and much more including umbrellas. We can stretch either the length or width of boots, add zippers, modify a shoe or boot's instep, create innersoles or put in heel counters so shoes don't slip off people's feet," stated Felipe Guamantari.
Handcrafted belts are an additional specialty of the successful Guamantari brothers. "Our belts are made-to-order using the very finest of materials. Customers from across the U.S. send us their specific requests for leather, width, color and buckle style and material. We also restore belts. We also specialize in cleaning and repairing UGG® Australia boots and shoes by removing stains and salt."
Located at 68 Stony Hill Road in Bethel, Shoe Service Plaza can be contacted at 203-297-6040. Their Southbury store is located at 134 Main Street South at Unit 69F in Bennett Square, and can be contacted at 203-405-6025. For more information, and to place orders, visit www.shoeserviceplaza.com.
Shoe Service Plaza
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Leo Gregory is a English film television actor. He has appeared in many films such as 'Green Street, Stoned, Act of Grace, Daylight Robbery, and Menace. He received widespread acclaim for his performance as the vicious, manipulative prison guard Daniel Kessler in the Silent Witness episode Redhill.
Gregory has also appeared in Goal 3! Taking on the World, The Big I Am, Bali Brothers, and Men Don't Lie.


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The question is what do I watch? With what images do I choose to fill my eyes when I venture beyond the printed page? Who else's vision in form and function has influenced me, given me joy, gifted me with solace?
Well, the short answer is that there are a whole bunch of them. I happen to love movies. I don't think I can name just one. Certainly there are a good number of movies I will never see if I can help it, others I wish I had not tortured my brain with. But so many that are creative vision given life. I do not have to work nearly as hard to watch a movie as I do to read a book. The movie has all the imagery there for me, waiting. I can sit back. Someone else has chosen the cast, picked the costumes, designed the scenery.
Sometimes that is a disappointment. I will never watch some movies because I feel they either will be a letdown from what they could have been, or I wish no one had ever thought of them at all. I will leave movies unnamed as this is not a place for a rant, nor do I wish to offend anyone who happened to enjoy those films I might list. Many of them are based on books I had already read and loved.
Sometimes it is a blessing. I must admit that I feel the Lord of the Rings trilogy fits in this category. With the exception of some particular things that bothered me that were changes from the books, I felt the movies were an improvement. The scope of Tolkien's imagination was given form and his long tracts of description could be deleted because they were no longer necessary. The foreshadowing could become visual or be left out as there was no need to ready the reader for something happening 500 pages later. The movies brought to life a world that had been imagined so many times.
Likewise, I am also a huge fan of The Dark Crystal and Labyrinth. Jim Henson coupled with Brian Froud makes me happy. The attention to detail, the vision required, the imagination they ask of the viewer. All brought me into a land of wonder from which I never really wanted to leave.
I am thankful for action movies of a number of varieties. Those based on comics, those based on the supernatural, those based just on blowing up as many things as possible. There is something about viewing destruction and violence a morbid fascination that so much of humanity shares, that is just flat out satisfying. I like watching things go boom. It prevents me from having to actually do anything drastic and I know nobody was intentionally harmed in the filming. It could be worse, I could be an ambulance chaser or someone standing around the tape at a crime scene.
I love musicals. Fred Astaire and Ginger Rogers, Gigi, 42nd Street, Singing in the Rain... Movies that make you happy to have watched them. Admittedly there are more difficult musical movies, such as Rent or Sweeney Todd which are also wonderful in their own way. I am, however, a sucker for happy endings.
I could probably name at least one movie of most genres that I enjoy, although it might take me a bit to find a documentary or a western. I love romances for the happy ending, cartoons for the childish joy.
Wall-E is probably one of the best movies I have ever seen. It is cute. It is also incredibly clever and well written. It takes incredible talent to create a story with very few words, especially when your characters have limited body language like, say, robots.
I hope this little glimpse into what I might be viewing has intrigued and enlightened, just a little bit.
And now to rewatch Underworld. I am in the mood for slaughter.


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ED Magedson – Founder
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The Doors Collectors MagazinePo Box 1441 Orem, Utah U.S.A.
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This report was posted on Ripoff Report on 06/02/2009 02:59 PM and is a permanent record located here: http://www.ripoffreport.com/reports/the-doors-collectors-magazine/orem-utah-84059-1441/the-doors-collectors-magazine-ripped-me-off-and-refuses-to-return-phone-calls-or-emails-or-457831. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 REBUTTAL Owner of company
SUBMITTED: Saturday, October 10, 2009POSTED: Saturday, October 10, 2009
This order was sent out the day after it was received...However the customers handwriting was so bad that we xeroxed his return address on the label when the order was sent out because none of us could read it. Obviously the postal people couldnt read it either because two weeks later we recieved the package back in the mail.
There was no other contact information - No phone - No email - so there was nothing we could do. When customer left a message on our voice mail complaining about not recieving his order, he left no phone number for us to call him back! No email was ever sent as customer reported. We do everything we can to follow up with people who arent happy, but we do not have ESP. Finally customer called during business hours and we wrote his address down and resent package and he received it. The Doors Collectors Magazine has been in business for 19 years and this is the only complaint... Id say a pretty good track record.
What customer said is true...after all his whining and unprofessionalism, I told him I didn't want to ever deal with him in the future.
Are you an owner, employee or ex-employee with either negative or positive information about the company or individual, or can you provide "insider information" on this company?
#2 Author of original report
SUBMITTED: Friday, June 05, 2009POSTED: Friday, June 05, 2009
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an animal that some people say they have seen on Bodmin Moor in south-west England. Some think it is a big cat, such as a lion, that has escaped from a zoo (= a place where wild animals are kept for the public to see them). Other people think that there is no Beast of Bodmin, and that people have simply seen large dogs in the fog.jump to other results
the Beast of Bodmin
BrE ; NAmE
Check pronunciation: the Beast of Bodmin


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|Bryan Pendleton <bpendle...@amberpoint.com>
|Re: [jira] Commented: (DERBY-587) Providing JDBC 4.0 support for derby
|Thu, 01 Dec 2005 19:08:06 GMT
> If anyone knows a way to get Ant to generate a list of files > (like the find command) that we could then filter, let me know. I'm always up for puttering around with Ant scripts. Between <fileset>, <patternset>, and <selector>, there's a lot of power there. Maybe you could send me some more details about what you'd exactly like Ant to be able to do, and I could fiddle with it for a while? thanks, bryan
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