text:
I So Ship ThatMature
I wiggle my bottom into the couch cushions trying to make myself comfortable. The tea in my kitchen brews and begins to make high pitched noises that make my ears bleed like a weeping statue. I'd invited Kamala over and she should be arriving any minute. I told her I need help planning interview questions for Aaron's upcoming assistant, but to be honest, I just needed someone to gossip with.
The doorbell rings and I jump up to answer it. A little spring in one's step never hurt anybody, it'll keep me young-- okay and I might be just a tad excited to see her. "Kam, hi, how are you. Oh Dearest it's been forever. Tell me, how have you been. Oh, you're practically glowing, are you pregnant. No, that's not it... gasp! You had sex! Tell me everything. Who was it with? Is it someone I know? Does the press know? I mean I know you're just an assistant, but someone like you could definitely date up to a star." She stares at me blankly, unsure of what to say. "Oh I'm sorry, come in, come in. Welcome to my humble abode as they say. Take a seat." I grab her wrist and push her down onto the couch.
"I didn't have... that word." She clenched her teeth together as she said it, clearly trying not to smile.
"Oh, you're a shy one now aren't you. Don't shag and brag, as they say? I bet you weren't shy last night. Tell me everything."
"I just told you all there is to say. Nothing happened." Kamala's cheeks turn a shade of crimson so bright I think I'm going blind.
"Okay, okay, I believe you." O.M.G. I so do not. I struggle to keep a straight face as I evoke those words. "So, let's talk about me!" My face lights up at the sound of me. Me. Me. Me. Such a beautiful word, and it describes such a beautiful person- me.
"I thought you wanted help with coming up with--"
"Oh pish posh! So there's this boy-- well really a man-- oh yes, he's very much a man. He asked me out, but I turned him down."
"Well- erm--" Kamala clears her throat. "if he's so great, why'd you say no?"
"Because," I drag out the last few letters of the word. "I want to know that he's committed to all this." I wave my hands down the grooves of my body. "I want him to get down on his knees and beg before I get down on my knees. If you know what I mean. Oh! I am so bad!"
"Wow Aaliyah, I've- er- never seen this side of you before. You must really be smitten. I know what that's like." She sighs the happiest sigh I've ever heard and rests her hand upon her cheek. I won't say anything yet, see how far she takes this.
"Yeah, he's okay." I struggle to find the right words to describe this imaginary man that'll make Kamala reveal the truth. I know they're out there though. "With his strong muscles, electrifying eyes, and... soft lips."
"Soft lips? Like Al-ex-s." As she speaks her voice gets quieter, almost inaudible towards the end. Nonetheless, there's my answer. As she realises I heard her, her eyes go wide, her hand shoots up to cover her mouth, and her body starts shaking with anxiety.
"O-migawd! I can't believe this. You and Alex... you and... a girl? I had no idea that's what you were into. Tell me everything. What's that like?" Kamalex, I like it.
"Shh, shh, shh. You can't tell anyone I told you, okay. Not even Alex herself can know that you know, but, uh, I have to, uh, go. Bye." With that she ran out my door in such a rush that she forgot to close it behind her.
Nonchalantly, I walk over to the door to close it, shielding my eyes from any potential cameras that may be waiting for me. Oh, the life of a star is not an easy one. I can't believe this, it's so exciting, I have to tell someone. Ooh, I know, Aaron should know. He can keep a secret. I start towards the phone when I hear it commence it's jingle-jangle ringtone. Creepy.
"Hello?" I'm always weary not to start off a phone conversation by giving my name away, helps to keep the crazed fans out of my hair.
"Hi, this is Craig Helm. I was just calling to enquire about that position you posted for. The assistant to Aaron Schaffer one. I'm a huge fan of his work, and- and yours too Miss Greene. I was wondering if I could drop my resume off and get an interview at some point."
"Oh! We'll get back to you. Thanks for calling. Bye!" I won't be getting back to him. I'm looking for someone hot to be his assistant. The girl of his dreams. I saw a psychic and she told me that other people's happiness will be a blessing. I'm pretty sure that means I have to get Aaron a girlfriend.
In my room, I lay with my laptop on my legs. The computer background is a picture of yours truly at an awards ceremony. What can I say, the people love to reward my distinguished work. Obviously. I open up a tab to my e-mail and see that it's flooded with people wanting to be Aaron's assistant.
"Okay, let's see. Ew. Delete. Delete. Del- ooh he's hot, I think I'll remember that number." Aaliyah focus. "Delete. Delete." This process carried on for quite some time. All the contestants were merely mediocre looking.
"Ladies and gentleman, we have a winner! Eep!" She is so pretty. Like not me pretty of course, but gorgeous nonetheless. I presume she's Swedish. Elsa Gynning appears to be her name. Let's see, she's a former model. That's always good. Blonde hair, blue eyes, fair skin, and it says here that she is "Motivated. Achievement Driven. Resourceful.". I guess it's time to e-mail her back saying I'd like to interview her. It'll mostly just be to make sure she doesn't snort when she laughs or have an annoying voice. Important details like that. Ooh, this is exciting!


text:
Are you tired of the typical tour? Do you want to travel with purpose and impact? Do you want an experience that will change the way you see the world?
Idea Trips are a new way for travelers of any age to see the world. Our structured, project-based trips aren't tours or typical service trips. These trips are real world engagements to explore global themes and inspire new ideas.
We take years of expertise in travel logistics (not as tour guides, but as global researchers and project partners) and combine this with our passion and interest for what's next. We design the most innovative itineraries for our groups. Our style of travel is authentic, personal, inspirational, and forward thinking.
From dinners with local friends (at the best, often hidden spots in town) to meetings with local leaders (who are part of our global community) and our custom field-research activities ,we carefully plan our trip to immerse our travel team in the trip project. Along the way new ideas are born.
The team behind Atlas Workshops has been leading innovative travel since 2009. From field courses with leading universities to social impact trips with creative nonprofits, our team has inspired new ways of thinking through our travels. Atlas Workshops evolved out of a real world global design group. While we continue to lead design research trips for companies, startups, and non-profits we are now offering our idea trips for travelers looking for something new.
Idea Trips are for travelers who want to get behind the pages of current events, who want to play an active role in global change, and who want to connect to like-minded travel team members and leaders around the world.
Are you tired of being a tourist? Develop new ideas with us!
On every trip, our travelers join in a real world project challenge.
Every trip inspires our travelers to see the world differently.
Our travelers become a part of a global network of leaders seeking global innovation.
Get in Touch
Adam White is the founder of Atlas Workshops and has been working in Kenya since 2010. He will be one of the leaders of the Future of Money Trip.
Mark Kamau is a thought leader on innovation and design in Africa. Mark is a proud Kenya creator who has led innovative research and design projects across the country, region, and world. He currently serves as the Design Lead for BRCK.
We are looking for travelers young and old who are interested in meaningful travel. You don't need any background in this style of travel, but you should be genuinely interested in the project. You don't need to have experience in Kenya — part of the fun will come from exploring a new place (or the same place differently) with your travel team.

subset: commoncrawl


text:
Having problems with your Samsung Digimax D53 Digital Camera ?
My computer hardrive crashed and I had a new one installed. I am trying to reinstall the Digimax D53 program. When I do the program says it was installed and the icon is on the desktop, but when I try to operate it I get a message that the program has shut off and I cannot get it to work. HELP !
Answers :
Uninstall the program. Then install again.
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Uninstall the program. Then install again.
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Repair Help & Product Troubleshooting for Samsung Digimax D53 Digital Camera
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My computer hardrive crashed and I had a new one installed. I am trying to reinstall the Digimax D53 program. When I do the program says it was installed and the icon is on the desktop, but when I try to operate it I get a message that the program has shut off and I cannot get it to work. HELP !
Hi,Uninstall the program. Then install again.\012\012\012\011\012\011\012Cheers\012TeaCii\012If you own website, add\012live support almost ... Samsung Digimax D53 Digital Camera
Camedia Master I have been using Camedia Master on my computer to edit my photos, for some time now. I like it very much. We have recently bought a new computer however, with Vista already installed. The program has worked fine until recently, but now when I try to use it, I get the message "A problem stopped the program working correctly. Windows will close the program and notify you if a solution is available." That is all that appears to happen, & I hear nothing from Windows! I just cannot us
To learn about the new and free version of Olympus Master 2 software go to: http://www.olympusamerica.com/cpg_section/oima_softwareMaster.asp ... Olympus Camedia C-740 Ultra Zoom Digital Camera
Reinstalling software When I try to open the Olympus software, I get a message the serial number is missing and I have to reinstall the program. I cannot find a built-in uninstall utility. When I try to delete the folder "Olympus," I'm told it can't be done because a file is being used somewhere. I can't install over the old program and it cancels itself. What should I do? Thank you for your help!
Close down the computer.\015\012Reboot the computer go to Control panel Add/delete software - find the Olympus file and click delete.\015\012When done do not re install, but put the CD back in the box, Windows does very well without it.\015\012If y ... Olympus FE-110 Digital Camera
My camera is working fine. But yesterday when I put it onto the dock and tried to download pictures onto my computer, I got a message that said: "Cannot get the devise information." I found my Easy Share disk and ran the "repair" program. When that didn't work, I contacted my Norton help line. A gentleman checked out my computer and said all was fine. Still couldn't download pics. He suggested I contact you.
Are you using a Kodak EasyShare camera? ... Digital Cameras
Lens error I have a Canon Powershoot SD1000 and it was working fine until one day the lens stopped retracting. Now it doesn't retract and I get a Lens Error, Restart Camera message. I looked at other websites to get help and tried some of the ways they suggest to fix it. Not sure if its working, because it still gives the same message and makes a noise sounding like its trying to retract then gives me the Canon welcome picture. I've only had this for a little over a year and would like it to be
HelloThe problem is that the lens has become stuck in the barrel. There are some DIY solutions you could try, but the \012probability is that you will have to get it fixed by a professional. ... Canon IXUS V2 Digital Camera
I have a new laptop that has vista on it. In the past I have used a desktop with no problems it used windows xp. I have installed software for my digital canon rebel xt and can go to those programs. When I connect my camera to download pictures I get the message "Found New Hardware". When I try to manually go to zoombrowser ex it will not allow me to download pictures. HELP
... Canon Digital Cameras
ACDsee software Hi, Your advice on upgrading Windows doesn't actually help me - i need help installing the camera software! I've just purchased a Pentax Optio S12 as a second camera (my first camera is a Pentax Optio S40). I'm trying to install the ACDsee software that came with the camera. I am familiar with this software as the 1st camera uses it (I already have a version on my computer) When I try to install it, I get an error message saying "Epson Scan cannot be started - do you want to open
Here is the Pentax Optio S12 software:http://www.freedriverload.com/all43095.html ... Aqua Pentax Optio S12 Digital Camera
I just purchased a Vivicam 25. I installed the CD and then tried to put a few pictures that I took onto my computer, but it is not working. Whenever I try to connect the USB cable to the computer, I get a message that says that the driver is not recognized. I already tried uninstalling and re-installing, and that didn't work. Not sure what the problem is.
I was logged into my computer as a "User" not an "Administrator," and when I went to install the Vivitar Image Manager cd, nothing happened--I found out that you have to be logged on your computer as an administrator to start the process--although, i ... Vivitar ViviCam 25 Digital Camera
I have a Nikon S6 digital camera, everything about the camera seems to work fine, except for this "lens error" message I keep getting. Sometimes I'll turn it on, and I can use it just fine. But then there are other times where I have to turn it off and on in order to get it to work. And then there are those times where turning it off and on don't help. I usually give up and try again later. Sometimes it'll still give that error message, and other times, it will just work like normal. What can
Fixing a Lens Error on a Digital Camera\012\012This has to be THE most common failure mode for a digital camer ... Nikon COOLPIX S6 Digital Camera
Need help Hi i have a Largan Chamelon Mega and I have the program download like i am suppose to but when i plug the camera in to my oc to get the pics I get a error message of Device Not ready ??? I dont understand why its doing this it has never done it before ...I have tried to uninstall the program and reinstall it but that hasnt helped any assistance would be great
If your computer is a Windows ME/2000/XP/Vista it does not need any additional software.Remove any camera associated software and simply plug the camera in- The Camera/Scanner Wizard will come up and ask what it is you want to do.Let Wind ... Digital Cameras
I am trying to open hp photosmart essential and I keep getting this message: This application has failed to start because hpqcutil.dll was not found. Re-installing the application may fix this problem.Well, I have uninstalled and re-installed several times without any success. I have even tried to find hpqcutil.dll to download it and can't.Please help me!
Search the CD you got with your HP printer for a file called L3. Its a special uninsstaller for complete clean up. Then get me the model number of your printer so that I can get you the latest version of the application which you can install. I am su ... RCA CDS1005 Digital Camera
I was given a vivitar vivicam xo14 camera and i went and purchased a memory card and now i am trying to get camera working but i don't have a manual so if you could help me out with basic operating instructions it would be helpful until i get a manual for it. It is coming on and everything just need to set camera up. thank you, ken
You may download a copy of the manual at http://www.vivitar.com/files_products/445/ViviCam_X014_Camera_Manual.pdf ... Vivitar Digital Cameras
I have a panasonic SDR 1140 I have problems editing video data and the Panasonic assistance team told me to uninstall and reinstall the software. each time i try to on both my PCs it saya that it cannot do it because there is a more sophisticated program already installed. i removed everything I had my Media Player Codec, from this PC I am using and it didn't help. When I tried to install it into my other PC which has hardly anything on it I got the same message. It is not the first time this me
Hi.\015\012\015\012\015\012The more recent version of the driver software is probably Windows default driver installed when you connected the camcorder USB before installing drivers from disk.\015\012\015\012\015\012If you hav ... Panasonic Digital Cameras
My camera was working fine . I moved the computer to another room. This is the problem when I try to transfer pictures from the camera to the computer I get an error message stating that the software is unable to find The Olympus Digital camera connected to the USB Port on your computer. Well I have tried eveything. A new USB cable, reinsatlling the program. Moving the cable to all ports on the computer. I took the camera to a friends and we insatlled the program on his computer and it did the s
Try to get a external memory card. And try that instead. It might work better than the usb. ... Olympus Digital Cameras
Fujifilm S1800 camera, 4GB card, over 2 GB full. Windows XP. When trying to download pictures, neither the Adobe nor Windows program will fetch pictures. I get a "device not connected or busy" message. Tried on another computer running 7. The folder shows up and can get to the DCIM but then it shows as 999_Fuji and 0 items. Have not tried/do not have a card reader. Any help??? Thanks!
Boss u ahve viruses in yr mem card.\015\012just use nero burn cd rec.soft to explore yr card in its menu\015\012\015\012or\015\012\015\012in the winxp address bar type the name of yr pic.folder it will open\015\012\015\012or\015\01 ... Fuji Finepix J20 Digital Camera
Hpqcutil.dll missing I am trying to open hp photosmart essential and I keep getting this message: This application has failed to start because hpqcutil.dll was not found. Re-installing the application may fix this problem.Well, I have uninstalled and re-installed several times without any success. I have even tried to find hpqcutil.dll to download it and can't.Please help me!
Copy all the files in "C:\\Program Files\\Common Files\\HP\\Digital Imaging\\bin" to "C:\\Program Files\\HP\\Digital Imaging\\bin". ... RCA CDS1005 Digital Camera
We have installed new xD-Picture Card M2GB into Olympus Digital Camera Model No. C-750 Ultra Zoom not work, Screen mentioned Card Error I purchased a 1GB Sandisk (used camera) but when I power camera on I get a "Card ERROR" message. The very first time I powered up I programmed the date and time....but then got the error message. Now I get it every time I turn it on. I don't have another card to test it with:(
Go here\015\012http://www.casio.com/home ... Casio QV-R40 Digital Camera
... Digital Cameras
My Vivitar Series 1 24-70 manual focus ais lens won't work on program in my Nikon FA. I bought both new, but have stored them for a long time. It works on aperture priority, shutter priority, and manual, just not in program. All my other lenses do, including other Vivitar lenses, so it must be the lens. Fresh batteries in the camera. I get the FEE message, which means the lens is not set on the smallest aperture, but it IS set on the smallest aperture. I have tried dismounting and remounti
You are correct - the lense should work with the Nikon FA!\015\012It sounds like there is a communication problem, and the lense is in need of repair.\015\012Your local camera shop should be able to take care of it. The repair should be l ... Digital Cameras
I cannot get the pictures off the camera. When I plug it into the computer the program will not recognize this camera my canon A590. So I am unable to download my pictures. I do not have this problem with any other of my cameras. At first I thought it was the usb cable, but I have tried other cables and they do not work either. Any Ideas. I use a mac computer and Iphoto program. At times, I have gotten it to work, but now nothing. Please help thanks T Riley
Consider NOT connecting your camera to your computer.\012\012\012The best way to download pictures from your camera to your computer involves removing the memory card from the camera and plugging it into a card reader (either built-in to ... Canon PowerShot A590 IS Digital Camera
I just recently got a new computer, I downloaded the Kodak EasyShare program, now I'm trying to upload my pictures from my camera to the computer,and it says 'Installing Device' then it says 'Device was not successfully installed'. It gives me no instruction about how to get it to Install successfully or why it wouldn't install. I have a Kodak EasyShare C813 camera. Please help! Thanks!
Consider NOT connecting the camera to the computer.\012\012\012The best way to download pictures from your camera to your computer involves removing the memory card from the camera and plugging it into a card reader (either built-in to th ... Kodak Easyshare C813 Digital Camera
My child broke the disk that came with camera. I tried to go online at aries and get a download. this didn't work now i'm stuck with a aries picture on the my computer screen that i can't delete. can you help delete this program. i can't find it in change or delete programs, or all programs.
Under the circumstances, best solution is to do the system restoring.\015\012\015\012Go to My Computer\015\012Click System properties.\015\012Select System restore and follow instructions therein. \015\012NOTE you select the system restore ... Digital Cameras
I'm no longer able to download images from my IXUS 75 camera to the computer. While trying I'm getting the message "cannot detect camera. Check the connection and try again." I have tried uninstalling the Cannon software and installed an updated version as suggested by Cannon, but without success. Everything worked find up until this summer. My computer is applying Windows Vista.
Even without the software, you can still download your image files from the camera to the computer. While the camera is plugged into the computer thru the usb cable, turn on your camera from there. Right click on the Windows Start button and choose ... Canon PowerShot SD750 / IXUS 75 Digital Camera
Installed driver kodakeasyshare m863, cannot load pics to computer, says driver did not install properly. when I install driver again, it says it was successful. I try again to load pics and get same message. have a new computer w/ windows 7. it worked before with old computer and windows xp.
Consider NOT connecting the camera to the computer.\012\012\012The best way to download pictures from your camera to your computer involves removing the memory card from the camera and plugging it into a card reader (either built-in to th ... Kodak EasyShare M863 Digital Camera
Memory cards hello . I bought two 4 g memory cards and when i install them in the camera i get an error message that sayus that there is a problem whith the card or that it is protected and cant take pictures. tried them at the shoping center on another camera and one works but the other one doesent but both still dont work in mine...???
Maybe the 2 card is lock try to take your card from camera and slide the small button at the right side of you memory card to unlock. ... Canon PowerShot A530 Digital Camera


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We are small business owners who live 10 minutes away from Rathtrevor Beach Haven. We are original owners who have rented our lovely condo for others to enjoy since that time. We take pride in our property and feel we have a lot to offer. Since we are close at hand, we take care of our guests directly – from providing easy access, to cleaning, repairs and anything in between. Beach Haven is truly a home away from home for all ages and we feel confident that you will enjoy it as much as we do!!


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Pearce was confirmed as manager on Thursday after talks between City and the Football Association ended in a compromise solution agreeable to all parties. Nigel Pearson has also been confirmed as assitant manager and with the addition of Wigley they will form a three-man coaching team for the eight-team competition in Holland.
Pearce said: "Nigel Pearson is working with me, so he will be there. Then in the summer I will have Steve Wigley as well, so it will be the three of us coaching the squad in the summer and they will be involved in everything I do."
Although Pearce will take charge for next week's friendly against Spain at Pride Park, he will sit out the proposed meeting with France in March, allowing him to concentrate exclusively on his club commitments for the remainder of the campaign.
"In decision-making terms, it was a no-brainer," said Pearce.
"From the offset, we were only talking about two friendlies in the season and a tournament in the summer. Now it is only one friendly and by the time we get to Tuesday evening, that friendly will be out of the way.
"I won't be directly involved in the March game, but I will be involved in the consultation as far as picking the squad goes."
Pearce will spot one familiar face when he meets up with his new charges on Sunday evening after City keeper Joe Hart - currently on loan at Tranmere - was called into the squad for the first time.
Matt Derbyshire and Gary Cahill are also handed debut call-ups, although the squad itself is particularly strong.
Micah Richards misses out, presumably as he is required for senior duty, but Wigan's Leighton Baines, Arsenal's Theo Walcott and Charlton keeper Scott Carson are all included, as is Kieran Richardson, who steps back down after winning his eighth full cap against Holland last month.
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text:
Systems Biology Opens New Research Pathways
Systems Biologists Are Attacking the Encrypted Messages That Would Allow Us to Predict and Change the Course of Disease
Individual Tumor Profiling
Has Tumor Molecular Profiling Enabled More Effective and Less Toxic Cancer Treatment?
Top 10 Under 40
Up-and-Coming Stars Shine in Biopharma Research and Business
Podcast: FDA's New Commissioner Hits the Ground Running
Scott Gottlieb, M.D., Commits to Speeding Up Drug Reviews, and Maintaining Safety and Efficacy
Virtual Management of Clinical Operations
Novel Web-Based Technologies Can Automate and Facilitate Trial Workflow
In 2005, there were 8,386 clinical trials costing nearly $24 billion in the U.S. alone. With clinical development being the longest and costliest phase of drug development, implementing best practices and streamlining processes in clinical trial management is a prime way to improve efficiencies, cut time, and reduce the cost of investigational product development. However, few succeed in maintaining best practices throughout a clinical trial, and potential savings are rarely realized. Much of the cause is the use of technology based on old business models.
Using technology for technology's sake under old business models will continue to result in failure to succeed. Traditional processes and function-specific software used by pharmaceutical, biotechnology, and clinical research companies are housed internally but are rarely compatible with each other. Because of parochial silos, turf wars often negate any of the positive improvement that technology and access to all available data can bring.
As a result, certain technology platforms have been underutilized, leaving sponsors wondering why they invested in nonpaper-based processes with marginal return on investment. The inefficient and unsatisfactory paper-based processes and disparate software tools based on old business models must give way to new era tools that automate and facilitate the clinical trial workflow process, making them more efficient and visible.
Clinlogix, a global full-service eClinical Research Organization (eCRO), sees the need for the clinical study process to change to help companies be more productive and competitive in this new era of biopharmaceutical and medical device development. To that end, Clinlogix has created a virtual development pathway that incorporates into its services certain new web-based technologies.
These technologies are based on new business models, further automate the clinical trial management process, and enable efficient project management. Designed to facilitate the clinical trial process, these web-based tools provide access to information, and integrate, connect, report, and deliver valuable project data and milestones and enable better cost management.
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Rokurobe Ryokan
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Travel Blogs from Hakone
Enjoy the Journey
... br>
I read several articles about hiking the Old Tokaido trail. However, there was some variability with the information. One Japan lesson I've learned is since we cannot often read the best source of information we have to approach most outings with a sense of adventure and flexibility. Initially I'd read that you could walk all the way to Hakone Yumoto station in 3.5 hours via this 400 year old highway. I made a plan for the day. In the morning, ...
I think there is something edible in there
... change into our yukata (light weight summer kimono) and contemplate the public baths. After reading the instructions for the bath, including no use of the baths following the consumption of alcohol, no swimming in the baths and no washing your underwear I rule out the public nakedness. That evening, adorned in our yukata and old man slippers, we head to a private dining room for traditional Japanese cuisine known as kaiseki, which refers to ...
... we finished our walk around the grass field, it was back on the bus to get to our accommodation. A small map reading error resulted in us getting off the right bus at a transfer station when we didn't have to. I realized my error as the bus was pulling away so we had to wait half an hour for the next one. Eventually we made it back on the right bus and to a train station which took us a short walk away from our accommodation. Our accommodation for the night was a ...
Mt. Fuji: a beautiful view from all angles
... a mid-aged Japanese couple came in after playing a baseball game. They spoke almost no English either but were really interested in talking with me (thank you google translate). We shared some hot sake (which I am beginning to LOVE) and some cold sake (do not like as much), and they helped me order some better food. We hung out for a while but eventually I left (had to make curfew). I enjoyed a nice soak in the Onsen at the top of my hostel ...
A day in Hakone
Today at breakfast we were seated at the other side of the room where the printed placements reflected the names of the towers we could view. Yesterday's placements depicted that view and we pity the poor trainee who might muck the placemats up! After receiving such attention to her personal meal requirements, they must have been happy to wave Naomi off. Just as well we still had Kaoru (our guide) to help us navigate our way to Shinjuku station, though the unforgiving ticket gates ...


text:
Game learning words for kids
Orçamento $250-750 USD
Game Words
Is a game that helps students become familiar with letters and words.
applications are connected to the server to download the album via the API.
Main fuction:
1. Manage albums
Connect to the server to download and upload API album
The album is a group of words related to each other on each topic. Each word contains information such as photos, words, sounds.
Parents can build albums for your child to attend. by creating an album, select the word to be learned, additional photos, and vocabulary.
2. Play
Players can have two modes of play.
a) Play alone, the game will take turns showing the vocabulary and images hidden some characters for players to choose the lack of additional characters to complete vocabulary. When word is completed, it will read the words that, and move on to the next word, the player's score will be added. In the game is not case-green or red font
b) Play with friends, each person will have blue letters, and red letters. When the game display images and vocabulary (hides some words) of a word on the screen, the two players must quickly find the missing letters to complete words that vocabulary. If any faster players, that player will have a point. Score of the two will be displayed on the screen..
3. Learning
Similar to the case of playing alone. But every self will be hidden from the first character. Players will find the missing letters to complete words there.
Visual effects and audio reference application.
[url removed, login to view]
Technological requirements:
Unity, Recognition letters, and colors. 2 colors are blue and red
Premiar a:
Hello, I have about 4 years of mobile application development experience in android and ios. I have developed games on unity before for both android and iphone please check these link: 1. https://play.google.com/ Mais


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Thunderhawk AH-73M Reviews (Amiga)
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Critic ReviewsMobyRanks are listed below. You can read here for more information about MobyRank.
CU Amiga (Aug, 1991)
If you're a person who thinks that yokes belong with eggs and a turbo-prop is an old biddies go-faster walking stick, chances are you've never played a flight sim. Most people are put off computer flight games after taking a look at the hugely complicated controls and incomprehensible manual jargon. Thunderhawk from Derby-based Core Design attempts to break this mould with a mix of slick graphics and a simple control method.
Amiga Action (Sep, 1991)
In the past many companies have tried to combine simulation and action games with varying amount of success. The usual result is something that satisfies fans of neither style. Thunderhawk has mixed both elements perfectly. The gameplay is fast and furious yet still has enough depths and realism to keep you coming back for more. On top of this the 3D routine is the fastest and smoothest I have ever seen. Good presentation tops off the outstanding package. Whatever type of game you play you should go out and buy Thunderhawk now.
The One for Amiga Games (Sep, 1991)
I have to admit to finding most flight simulations a bit daunting. Don't get me wrong, I have played my fair share of 'realistic' simulators and there is a real feeling of satisfaction to be gained when you get things right but I rarely have the time or patience to read the necessary manuals and practice enough manoeuvres to get the most out of them. What I really want to do when I'm at the controls of millions of pounds worth of military hardware is blow some enemy machinery to smithereens... so thank heavens for Thunderhawk. This is action all the way, with little or no worrying about dry technical matters to slow things down. What's more, the storyline is more than just a cosmetic add-on, it makes you feel like part of a much bigger operation and gives an added incentive to complete each mission successfully.
Zero (Sep, 1991)
Thunderhawk's great feature - it's simplicity - is also its first stumbling block, Everything is controlled, rather smugly, with the mouse. Mouse movements control thrust and direction, while the buttons operate the weapons and radar. And of course, since no one understands the logistics of helicopters (because they're so silly) you will try to fly the chopper like a Fokker (ie a plane) - Many collisions with that old faithful - the friendly hangar - will follow, then you'll progress to fatal crashes into that old chestnut, the ground. Where would flight sims be without these two stalwarts, eh?
Amiga Format (Sep, 1991)
Thunderhawk creates a thrilling 3D environment, filled to the brim with bullets, blasting and battles. Its unique control system promotes last learning and allows the game itself to start at a sprint. Trick flying and quick firing are the only routes to survival from the word go. Segmented well with animated briefings, each campaign is a story that you create with brave deeds and hot flying.
ACE (Advanced Computer Entertainment) (Sep, 1991)
Presentation and ergonomics are excellent throughout, and all the words about thought being put into how the game is played, putting the fun back into flight games which sounded so hear-it-all-before a couple of months ago have been proved to be justified.
Computer and Video Games (CVG) (Sep, 1991)
The graphics are simply superb - not as fast and smooth as the vacuous F-29 Retaliator, but more than adequate - and the fading light on the twilight missions is very effective indeed. The sounds are equally spectacular, and I'm not just talking about the brilliant rocket, gun and explosion effects, either - the animated intro, as well as looking good is full of excellent speech! This is one of the best Amiga air combat games I've seen, so even though it's not the cheapest it's got to be bought!
Amiga Computing (Sep, 1991)
It's been a long time coming but finally a really sensational helicopter simulation has arrived – well almost, it should be released about now. In the past, many a programmer has tried to master what is perhaps the trickiest form of flight, usually with mixed results. In the case of Thunderhawk, Core Design have produced what many a flight sim fanatic has been waiting for: a playable, and more importantly a believable, chopper simulation. Probably the best comparison to Thunderhawk is the Electronic Arts classic Intercepter which never claimed to be the ultimate in realism but is one of the most enthralling action sims on the market.
Amiga Power (Sep, 1991)
At last, a flight simulation for the layman. It's hard, but in a decent, honest sort of way, and at least it makes it easy for you to give as good as you get.
Amiga Joker (Oct, 1991)
Core Design hat es geschafft, bei dieser Hübschraubersimulation alle wichtigen Funktionen auf die Maus zu legen, ohne dass deswegen auch nur ein Quentchen Spielspass verloren ginge! Steuerung, Motorleistung, Feuern, Waffen- und Zielauswahl – alles wird komfortabel mit dem Nagetier kontrolliert, die Tastatur benötigt man lediglich fur seltener gebrauchte Funktionen (Karte, Aussenansichten, Schadenfeststellung, Infrarot, diverse Stormassnahmen wie ,,Radar Jammer").
Amiga Power (Oct, 1991)
A brilliantly executed arcade-simulation crossover, which captures the frenetic helicopter feel quite excellently.
Play Time (Oct, 1991)
Abgesehen vom Intro und den Sequenzen im Headquarter ist Thunderhawk eine typische Flugsimulation im Vektorgrafikstil. Allerdings recht soft und fein zu fliegen.
ASM (Aktueller Software Markt) (Sep, 1991)
Bei diesem Programm überwiegt eindeutig der Actionteil. Die Steuerung der Maschine ist auf das Wesentlichste beschränkt worden, wobei aber die Maus mit Steuerfunktionen überbelegt wurde. Zur richtigen Simulation fehlen einige Dinge wie z.B. die Möglichkeit, den Helicopter bei Triebwerksausfall durch die Restrotation des Rotors notzulanden. Ansonsten aber ein nettes Spiel ohne große Realitätsansprüche.
Power Play (Oct, 1991)
Die Programmierer von Core wollten mehr Action in die Simulation bringen, und das ist ihnen auch gelungen. In vielen Missionen wird man gleich nach wenigen Sekunden von allen Seiten unter Feuer genommen, weil der Autopilot Sie zu Anfang gleich mitten im Zielgebiet absetzt. Da wird das Spiel sehr hektisch, und manchmal verdarb diese Eigenschaft mir den Spielspaß, anstatt ihn zu erhöhen. Technisch kann man Thunderhawk keine Vorwürfe machen: Das 3 D ist flott, die Steuerung auch mit Maus recht intelligent. Spielerisch hingegen hat es mich nicht hingerissen - das mag auch daran liegen, daß das inzwischen die hundertsiebzehnte Flugsimulation ist, und eigentlich nicht viel Neues bietet. Für Amiga und ST ist das Programm mit Sicherheit ein guter Griff, denn außer dem betagten Gunship gibt es nichts vergleichbares. Auf dem PC würde ich den "LHX" von Electronic Arts in jedem Fall vorziehen.


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J VR Imports & Exports telephone number is (954) 389-2303.
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This Lock Stock & Barrel Preptonic Thickening Tonic helps to build strength, volume and thickness whilst also giving a versatile hold and a natural finish. Leaving a light, masculine fragrance on the hair and containing a unique blend of protein, this modern interpretation of an original hair tonic infuses each hair strand immediately after application in such a way that strength and volume will be added from the root to the tip. - E.D
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Alexander Lukashenko said yesterday he will decide "soon" whether or not to commute the death sentences given to two 25-year-old men by a Minsk court this week, for bombing the city's subway system in April.
The Belarusian leader said he "could not complain" about the court's decision, but would now consider whether he should exercise his presidential right to grant clemency.
After a trial almost entirely based on confessions that rights activists fear may have been extracted using torture, Dmitry Konovalov and Vladislav Kovalyov were sentenced to death on Wednesday. Konovalov did not speak once during the whole trial, while Kovalyov recanted his confession, saying he had been pressured into signing.
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Movies I Want to See Before the Oscars
After watching the Golden Globes on Sunday night, I realized that there are several movies that I want to see before the Academy Awards air on February 28.
After watching the Golden Globes on Sunday night, I realized that there are several movies that I want to see before the Academy Awards air on February 28.
The 2016 Golden Globes winners will be announced during the ceremony hosted by Ricky Gervais on Sunday, January 10 at 5 p.m. PST/8 p.m. EST on NBC...
Stephen Sondheim just slammed Lady Gaga's 2015 Oscars performance, calling it a "travesty." Yikes.
After six years, one of the Oscars' boldest (and most desperate) experiments may be coming to an end. In 2009, the Academy Awards changed its rules to allow up to 10 films to receive Best Picture nominations. The thought process was simple enough: with double the potential nominees, more mainstream fare could get nominated and ratings for the annual Oscars telecast would increase. But that didn't work. This year's ceremony was a disaster (in more ways than one) and the Academy is apparently ready to call this whole thing off and return to the old ways.
The LEGO Movie may not have been nominated for Best Animated Feature at the 2015 Oscars, but one of the highlights of the show was still the performance of "Everything is Awesome" by The Lonely Island with Tegan & Sara. During the song, dancers from the stage came down into the audience and handed out LEGO Oscar trophies to Emma Stone, Steve Carell, Channing Tatum and Oprah, who was really excited.
Neil Patrick Harris took on the job of hosting the 2015 Oscars and the pressure that comes along with it.
The 2015 Oscars were an awards show to remember! From memorable performances to Neil Patrick Harris' hilarious hosting moments, this was one buzz-worthy night.
The 2015 Oscar Best Picture race was highly contested and no one was sure who would win, but Alejandro González Iñárritu's Birdman ultimately won the award, beating out Boyhood, for Best Picture at the 2015 Oscars.
Actors and actresses make sure they dress their best to strut the red carpet, but some gorgeous celebs give the red carpet a more wedding aisle vibe by donning white. The 2015 Oscars were no exception, with countless women channeling bridal by opting for dazzling white dresses.
You cry, I cry, we all cry for "Glory."
Lady Gaga performed a medley of "The Sound of Music" songs at the 2015 Oscars and she totally blew us away.
Rita Ora belted out a stellar rendition of the Oscar-nominated song "Grateful" at the 2015 Oscars tonight (Feb. 22), looking absolutely radiant while doing so.


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- Suzanne Hopgood , p resident and CEO, The Hopgood Group LLC; former crisis CEO at Furr's Restaurant Group (FRG) and Houlihan's Restaurant Group; former director, Del Global Technologies, Point Blank Solutions Inc.
- Michael J. Berthelot , director, Fresh Del Monte Produce Inc.; CEO, Cito Capital Corp.; managing principal, Corporate Governance Advisors Inc.
SAN DIEGO, March 19, 2013 /PRNewswire-USNewswire/ -- Since directorship is increasingly complex and has ever-expanding responsibilities, Corporate Directors Forum 's Governance Academy is now offering a two-day training course geared toward expanding directors' boardroom competencies, confidence and personal network. (Logo: http://photos.prnewswire.com/prnh/20121130/DC21508LOGO) "The Essentials of Corporate Governance" training course, held May 16-17 at the University of San Diego, will be an interactive, dynamic learning experience led by nationally respected directors and boardroom leaders who "bring the boardroom experience to life" by actively engaging attendees, drawing from real-life experiences and including relevant, recent business developments. Lead instructors include:


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Chanel Camellia Necklace Silver Authentic Pre Owned
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Authentic: Pre Owned
This is an authentic Chanel Camellia Necklace in Silver. Featuring thin chain and rhinestone .A truly gorgeous Chanel!
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Product Code: 1961011
All photos are of actual item being sold. This Chanel® item is guaranteed to be authentic. Chanel is a registered trademark of Chanel. LuxeDH is not affiliated with or represents Chanel in any way or form.
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anaheim Tag
In Events, K1 Speed Anaheim by K1 Speed Staff Writer with No comment
Reverse Wednesday at K1 Speed!
Join us for Reverse Wednesday starting Wednesday, October 1st at K1 Speed Anaheim! Be the first to lay down some laps in reverse direction! Enjoy our NEW track layout…
In Events, Featured, K1 Speed Anaheim, News – K1 Speed by K1 Speed Staff Writer with No comment
The 4th Annual VidCon Pre-Party Hosted by Tubefilter and Big Frame
Come join us at Tubefilter's VidCon Pre-Party fueled by BigFrame! Once again Tubefilter and Big Frame are taking over the racetrack for the annual VidCon kickoff party Wednesday June 25…
In Challenge GP by K1 Speed Staff Writer with No comment
2014 Challenge Grand Prix // Season 1 // GP 1 Results
The 2014 season is here! We are proud to announce a new center joining the league this year – K1 Speed San Diego! San Diego is the first K1 Speed…
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Jul 30, 2012|
Yahoo! Sports baseball columnist Jeff Passan joined John and Gerry to discuss the possibility of the Sox trading Josh Beckett. Jeff mentions which teams might be interest in Beckett, if the Sox are desperate to move him no matter what, will Beckett be more likely to be moved after the non-waiver deadline, and predicts what will happen in the relationship between the Red Sox and Bobby Valentine.
Transcript - Not for consumer use. Robot overlords only. Will not be accurate.
League baseball columnist Yahoo! Sports justice on Jeff good morning Howard John and Jerry in Boston thanks for ticket a couple of minutes. Or outward to one very very well the hue and cry if you might expect here in Boston is its about time that the Josh Beckett experiment which is failed miserably. Ends and they should be sellers not buyers what's your sense based on what I have read that you've written this morning -- last 24 hours. The threats are slaughtered them Josh Beckett there's absolutely no question about it today they have made it. All around to a -- you -- -- I was able but it. Figure out which was the Atlanta Braves and the Texas. Strangers. Inquired about the idea. Dumping Beckett and paying a lot of his salary sort of in AJ Burnett type deal. It. Neither of those two teams loses particularly entry that the amount of money that was. Being offered back to them and the idea that taking on -- clubhouse in the idea that. I could be acquiring gotten lost in my Obama's staff all over the last year and bringing and a guy who's got two more years left Abbott deal and they don't know where his -- it anymore and so. This is proving far more difficult than you would imagine for a guy coming up to 89 the area season with the postseason pedigree that he's gotten. -- show you the the toxicity that -- Josh Beckett these days. -- of all his -- baseball skill flaws that we think is is money the biggest obstacle of them all going forward. Yep definitely. I mean here here's the thing is -- -- -- work better pitcher today. The -- are saying wouldn't be looking to dump that salary because they felt this crap before when he was pitching well. And -- it wouldn't have much trouble dealing with the guys so. 37 and a half million dollars. Over the next two at 130 years and it's the same situation look -- -- -- all they need to actually -- faced similar situation to have everywhere. Being defined -- irked by the rather that is going to take up that money but -- complicate it with back it is he's got satisfied right. Which means he's been in the big leagues for ten years. Some of the same -- for five years and is it is able to block any trade and so. The reason that Atlanta and Texas were contacted was because. Other Red Sox believe that that it would waive any waited five great security either place I know for a fact. That there have not been high level discussions with the Los Angeles starters who. Would be interested because there were concerns over Beckett waiting he'll. Nor their -- -- -- Louis cardinals and other gene that makes sense and -- starter and would like to get a guy on the cheap. Well there and the market is thinning. And Jeff I'm looking and you obviously great keys on Monday Rodriguez Francisco Liriano. Is there a point where there will be no other pitching available and team and maybe. Teams that their desire to take on Beckett and and some of the money -- becomes greater if if the Sox wait -- say. You know 3 PM tomorrow is likely does likely would grow. I doubt it I think their best bet is to wait until August actually and that's why I think this thing is gonna linger. I'm not sure anybody would pick up Josh Beckett on waivers and I think first. First thing first went waivers are available are player. Threats are gonna throw Josh Beckett out there and see anybody by some that contract in the -- You can go ahead when nobody fights all the sudden you got another thirty days on top of that on manufactured deal. He got a chance to bettors see where -- hard to make some headway in the standings. -- a chance to get back and pitch a little bit better because that he's just picking through thousands per cent and an English -- back to back starts. Is -- going to be a lot less leery of small sample size. Not stand. Well one thing you've done Jeff has kind of try to explain what happened to -- mean he's five and nine. Sets and tough luck but he's no where near the pitcher was even last year as you point that many of the 289. You. Reading this morning last year. This fastball. Averaged 93 topped out at 96 this year. He barely reaches the average velocity from last year. Hardest fastball he threw in the last month was 93 and half in his average was 91 point five. Does that is that from scouts is that from baseball people as he just lost his fastball literally. I mean that that's from the actual data that is collectively every ballpark -- -- let beckon. Lecturer restriction that extra on the sheer artistry -- are all -- 93 point nine miles per hour. -- -- last month to nine victory after the match or show you something or not it was mechanical flaw whether injury. Whether he's attache. In -- you know what it's reaching on him. Popping up with Josh Beckett this sport and where when you luge or fastball. And you've been mainly I mean Josh Beckett the guy -- in the past the -- apple two thirds of the side. He are less than 50% of the -- -- anybody thought about ease he understands that the apple. That happens used that I want it and so he's changed style pitch in according I think he's become a lot more credible. Tip -- -- from Yahoo! Sports this is more of an observational questions opposed to a factual one based on the September collapse the historic September collapse last fall. -- Josh Beckett clearly sitting in the middle that -- did you. Like most people think you would see a different motivated. Productive Josh Beckett and Lester by the way we can throw him into that into that group as well. This year coming out of that last horrible offseason. You know at the very question. I don't think so because. -- that that the government let the pitch and he's always there and yet you that he was gonna out now to. You know did the idea that. But that was. In Josh Beckett he had -- have that was and his plan that he was gonna go to. What he wanted to -- and if there were people questioned his work but the work ethic you know. Shortcut whereas. Apple is which are expected always. He's always been an end. You know I I think it is much as just that. Attitude personally rubs people the wrong way I've never been able to deny the guy's ability to go out there. You bet it's been a great thing about pictures probably the thing that made it most successful just that attitude of wanting to go out there. In the back. And the problem and let the stuff and that's the attitude you see what happens. Right and when pitchers and catchers report to Fort Myers, Florida in February. Was more likely not to be present Bobby Valentine -- Josh Beckett. It broke both put it that way you'd be surprised they both there. I would be flattered that you think you're thinking about that survives the season. Well survive this is an important right. I do you think they and I'm leaving the Valentine era and -- -- well. I think get them in a mushroom cloud. And I think a lot -- anything that people may realize it really and your own hunch or we talk and some real reporting here. They've they've been it's sort of. Or are -- -- informed hunch more and so it could end before the season. I heard of it and report it I don't know I don't know about. -- these. Let the guys know what's been reported out there and and you know peace deal lesions and the things that you hear. And and don't don't necessarily have the ability to rub. These because. Nobody wants to confirm that necessarily but. I it would shock me in it would be a few months is. What's the what sort of like -- your -- show -- hubris. By Red Sox ownership to bring about the downside back for another year. Well any any ideas -- Thoughts on a successor -- we go through the same list we last saw. But you know maybe ten series and actually allowed the -- of the generals are a bit demented. Tyson different let the G ally of the medicine. And what would. Heard before 4 PM tomorrow -- the Red Sox do something big something small or nothing at all if you had -- -- -- I would days. -- they I would say something's. Small pattern now that I see. Sitting there and making a blockbuster deal but I don't know that and their DNA is to sit by idly. When but -- -- and -- you'd like this team or not they either 500 the only four games back of the second wild cards are right now and one of those scenes it would the first wildcard spot for -- -- out of them is the Oakland day. He met a lot of people still think it is all purple and so. They've got a lot in the -- aren't they got a jump over to try to figure jump over Tampa Baltimore. Around there. They've got a law that get up to those wild card spot it's a lot -- to jump other teams that is necessarily that make up. Games in the standings. You know I still look at that -- look at the roster look at talent in. Wonder why the -- -- 500 right now and whether that can change with a good round. Now we're -- would just pass and from Yahoo! Sports league baseball writer. Do you think there has been much interest in Jacoby Ellsbury and how much stones would that require for the Red -- to Sega by the -- your early. There's a lot of interest and that no inclination to do anything at this point because. We were. I think because they don't think that there's a whole ton of value for him right now I'm not the injury and they realized that they give them some odd play and do what he's capable of doing. -- get a lot Portman neo Nazis in the future used to rather they couldn't. Dick get the more at the deadline next year. Again they're struggling I just don't think that they want to get rid of the guy at this point though. Who's. Near bottom in value there are Smart management group that. They they get that jovial there's an important part of this team in -- thirteen in. You know it and let the outfield is it is fair question marks there because you know we dropped Carl -- -- Manitoba surgery and we're -- erupt if you want your anchor in center field certainly that's what that desperately that a year ago there. It just pass and from my Yahoo! Sports league baseball columnist thanks for taking a couple of minutes in explain it to -- Jeff on this a day before trading and I'm leaving us with one image a mushroom club hit that's got tips addiction. On how the Bobby Valentine -- will and in a mushroom cloud like thanks Shipley talked it down the road. Just pass -- with Yahoo! Sports a built in -- element AT&T hotline AT&T four G your attention and they didn't mean really this and they ago. But as you said. He's obviously these little bit provocative but he is working the phones if you read and he's talking baseball people he's trying to. Engaged the trade marketing and all the talent -- she did -- Beckett that's impressive yeah nominee desert greatest and that's -- host talk I was too but how difficult it is to explain pitching right to understand pitching more when it comes and goes and you -- but -- slots and the like. That's about as simple as that gets he averages 91 -- That is a batting practice fastball. To a lot of guys you know that in in Major League Baseball you'd better be movement if it's 91 well. And also as the last line of that particular paragraph where he says he was 93 on average last year 91 point five this year consequently Beckett is throwing. Fewer fastballs than ever before relying more on a cutter that what executive says is far too marketable. So if that's the case. I could see the -- the lack of a market for yet but even though is a post season ignited Gutierrez last year and and Goodyear until September. And even though he's proven in the post season. If they have that data in front of them and I assume they do their sand. He's losing or he's lost that -- she and her -- is viral right. Hogue is it the kind of got a look at and they say -- change of scenery a hell if you thought Youkilis was loosened. You courses 33 just had an injury. Beckett the unit if you think he's -- and like he's reaching the end of the road you don't touch from 37 million during. Here's what I do. I get that warm soy milk this who went to history in Washington plan that adds to in the watery rice water rises to you think -- lower court I would he won't let immediate in the clubhouse during the game.


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From OpenWetWare
|Information concerning the
Keating Lab
Amy-approved candidates
List of candidates (from group)
- Barth P, Schonbrun J, Baker D., "Toward high-resolution prediction and design of transmembrane helical protein structures", Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15682-7 PubMed.
The prediction and design at the atomic level of membrane protein structures and interactions is a critical but unsolved challenge. To address this problem, we have developed an all-atom physical model that describes intraprotein and protein-solvent interactions in the membrane environment. We evaluated the ability of the model to recapitulate the energetics and structural specificities of polytopic membrane proteins by using a battery of in silico prediction and design tests. First, in side-chain packing and design tests, the model successfully predicts the side-chain conformations at 73% of nonexposed positions and the native amino acid identities at 34% of positions in naturally occurring membrane proteins. Second, the model predicts significant energy gaps between native and nonnative structures of transmembrane helical interfaces and polytopic membrane proteins. Third, distortions in transmembrane helices are successfully recapitulated in docking experiments by using fragments of ideal helices judiciously defined around helical kinks. Finally, de novo structure prediction reaches near-atomic accuracy (<2.5 A) for several small membrane protein domains (<150 residues). The success of the model highlights the critical role of van der Waals and hydrogen-bonding interactions in the stability and structural specificity of membrane protein structures and sets the stage for the high-resolution prediction and design of complex membrane protein architectures.
PMID: 17905872 [PubMed - in process]
- Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS., "Functional specificity of a hox protein mediated by the recognition of minor groove structure", Cell. 2007 Nov 2;131(3):530-43.
The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly understood step in the control of gene expression. Members of the Hox family of transcription factors bind DNA by making nearly identical major groove contacts via the recognition helices of their homeodomains. In vivo specificity, however, often depends on extended and unstructured regions that link Hox homeodomains to a DNA-bound cofactor, Extradenticle (Exd). Using a combination of structure determination, computational analysis, and in vitro and in vivo assays, we show that Hox proteins recognize specific Hox-Exd binding sites via residues located in these extended regions that insert into the minor groove but only when presented with the correct DNA sequence. Our results suggest that these residues, which are conserved in a paralog-specific manner, confer specificity by recognizing a sequence-dependent DNA structure instead of directly reading a specific DNA sequence.
PMID: 17981120 [PubMed - in process]
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Living in MN, we hear this a lot in winter. :)
Awesome quality. I am using in a video/powerpoint that will accompany a non-profit exhibition in Nebraska next year. Here is a link to the project: http://hildegardcenter.org/3864-2/
Thank you for providing this!
Fantastic! Just what I needed. Thank You!
Sounds perfect
This worked great. I used it here: http://youtu.be/g8aFVvnWi14
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Beautiful sunset with a beautiful girlMature
I'd never shared this place with anyone before, not even my ex. She hadn't appreciated my passion for landscape, for nature and for the world. She could only appreciate fashion and the latest magazines and styles. I startled myself thinking of her like this. I wasn't used to it; normally I couldn't find a bad word about her, except that she'd broken my heart. Perhaps this meant that I was over her. Suddenly I felt confident, more so than ever before. I braced myself against the sky and would have yelled out in triumph if Cerice was not next to me. I let my eyes wander to her face; she was staring out at the sunset as though it were her very life. She looked incredible in the sunset. Then her eyes met mine and I blushed, wanting to pull myself away but not being able to.
She blushed and I felt guilty. I was making her uncomfortable, I knew I was. I tore my eyes away, even though I didn't want to.
"Sorry. I was just thinking..." Oh quick, lie. Think of something clever. "... that this would make a really good painting."
"Oh." I saw her drop her eyes next to me, and she began fiddling with her jacket.
"Yeah." Damn. This was not going well. I wanted to bury my head in the sand. "So um, did it freak you out earlier, you know, with Sam talking about getting a boyfriend."
"Um no. I just wasn't expecting it."
"Yeah cos Sam is so butch." I said laughing. She looked offended for a moment and my heart skipped, but then she shrugged and laughed with me.
"Fair. It's just, where I grew up, being gay is a sin, especially for my parents. My friend, she got thrown out of school because of it."
"Oh. That's horrible." I felt bad for her and wanted to take her in my arms.
"Yeah. If they knew I was... talking to gay people they'd have a fit." Ouch. But it didn't sound like Cerice had inherited this homophobia.
"But, you don't think the same as them right?"
"No." Her face twisted, as though she was confused. "I just find it hard to adapt when I've spent so many years with all that hate."
"Yeah, I can understand that. My mum and dad chucked me out over it."
"Over... oh."
"Yeah I'm a lesbian." I chanced a glance at her, but she didn't seem freaked out. Well, maybe a little, but not like she was going to run away or anything.


text:
Car Vision is Proud to be independently owned & operated by the Husband & Wife team Cafiero. We are proud to have Sold over 20000 cars trucks and sub's and to give back to our community.
Pre-Owned Used Car with Efficient Services
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text:
What Does California Need? More Water Storage or Better Water Management?
Is the question more water storage or better management of our water resources in California?
"I think it's gonna take both. You got a water system for 20 million and we have 36 or 37 million," Assemblyman Dan Logue said.
Logue is taking fellow Legislators on a tour of what would be the Sites Reservoir in Colusa County.
"30 percent of it will be used to flush the Delta, to keep the salt level down. It's great for the environment, it's great for the economy and the farming and ag industry. It's a lifesaver is what it is," Logue said.
Logue hopes his colleagues will see the potential of the site and vote for the water bond, if not at the current $11 billion that many say is too much to pass, then a modified version that would still include the Sites Reservoir.
The reservoir would begin providing water to local residents and farms in seven to nine years.


text:
Bitter TruthsMature
"How could you let him escape!?"
Soris flinched as scream echoed about the ornate dining hall of Jim Randus, a Divine who held nearly an eighth of Fetona's wealth in his companies and stocks. He was a tall man, though not very muscled, and had eyes that made any man, no matter their size, feel fear. He was truly a man to be feared.
"Do you not realize who he was!?" Randus yelled once more. There was no one in the room to see them argue, but it would be no surprise if the other officers outside heard every word. Randus was a powerful man with a powerful voice. "I heard the reports several times over. You let him get away! Is this a lie?"
Soris made sure not to look the man in the eye. Instead, he focused on Randus' hair. It was dyed as black as the night, a style taken up by a few warriors that took place in the Tourney, and pushed back like some sort of viper. In a way, Soris saw Sish in Randus. A taller and differently powered Sish, but him nonetheless.
"Yes, sir," Soris replied, "But there was nothing I could to do kill-"
Soris was silenced by pain filling his face. The next thing he knew, Soris was on the ground. Radiant God above! Randus had punched him! He was much more powerful than he let on…
"You fool! You can NOT kill him! Do you not realize just WHO he is?!" Soris must have looked utterly confused for Randus simply rubbed his hair back and sat down in a nearby chair. "Forgive me for striking you, Captain Vandeel," he said calmly, his voice housing an edge of venom, "But I was angry. You see, that boy is none other than the fifteenth Herald, the prophesized Savior from the destruction we face."
Soris stood up immediately. "That is impossible!"
Instead of growing angry, Randus smiled. "You should have realized this as soon as he picked up that officer, Captain Vandeel."
"But… Divines can pick up humans, too! I have seen it!"
Randus shook his head. "The most powerful Divine can lift one human body and it takes him nearly an hour to do so, so no one really worries over it. This boy, as the reports say, was using two bodies with ease. Tell me that there is an explination?"
Soris racjed his brain but found nothing to explain it. Randus was correct, then. But, this wasn't the reason Soris had come to the Divine first. "Sir, there is something I must tell you."
Randus grabbed a cup of wine off the dining table, most likely a leftover one. Unlike the other Divines, Randus was willing to do anything to save money, even if that meant drinking leftover wine. "And what is that, Captain Vandeel?"
Soris swallowed. It had been only a day since the disaster at the Execution Block, but Soris still felt the weight of that boy's words. 'None of the Nomads were ever in Fetona.' "The boy – Sish – said that there were never any Nomads in the City. He said that they only came when they had a raid."
Randus simply stared into his wine. Soris should have been thankful he didn't stare at him with those eyes… "Is that so?"
"Yes," Soris replied, then continued, "He also said that the only rebels we have captured were the two of them. W-would that mean…" Soris could continue. His throat tightened and he felt himself on the verge of tears.
Randus didn't move. "So, you are saying we have been slaughtering our own people and they were innocent?" The Divine was unreadable, to Soris dismay. He was not afraid of many people, but Jim Randus was definitely one of them. It was a pain, but something drove Soris onward. Guilt, perhaps?
"Sir, do you think there is any truth to the boy's words? Could we have been… killing innocent men and women?"
Randus stood and walked away, his hair and robes flowing from an open window that Soris had just noticed. Why was it not cold? "It is true, Captain Vandeel," Randus replied slowly, his voice filled with something alarming. Sorrow.
"How do you know, sir? Surely you do not have doubts that the boy was lying?!" Soris was growing desperate. He didn't want to be a murderer of innocents. Killing was bad enough as it was!
"Look, Captain Vandeel, I know you are a very religious man," Randus said, "So I know you know about the Abyssal God's recycling of souls." The Divine turned and faced Soris with a hard look. "Do you realize what that means?"
Soris couldn't answer. He always put on a front. Everyone thought he was a hard captain with a soft heart, a man of the Trinity Gods, and even a reliable person who anyone could come to. It was a lie. He only did what he could to keep them thinking that. In reality he was lazy and had little faith in the Gods. He sometimes doubted they existed. And so, he could not say anything.
"Look," Randus said, his voice actually growing soft, "There is a cost to having a child in Fetona. In order for a life to be born, a life must be recycled." Soris felt himself grow dreadful of what he now knew was to come. "The Officers were made after Fetona's construction for two purposes: the first was to protect, and the second-"
"-was to recycle…" Soris finished. Randus nodded sadly.
"It is a sad thing, but something that must be done. If not, how would new life be brought forth?" Soris felt himself nod. He actually understood this, though it pained him to hear it. He had already lost Sarah to sickness. He couldn't afford to lose himself to guilt. "We find those who are tainted, though, and leave peace to the innocents."
Soris raised his head and turned to leave. "Just… please tell me I am doing the right thing, sir." He needed someone's approval, even a man like Jim Randus who was said to be cruel and evil by most the Commons and even feared by Divines.
When no answer was given, Soris walked from the room, despair gripping his heart.


text:
Contact us 24/7: +1 877 678 9627
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- - Italian sizing
- - True to size
- - This boot is designed to slip on and may not be suitable for feet with a high arch
Heel measures approximately 125mm/ 5 inches with a 25mm/ 1 inch platform. Add instant attitude to your fall wardrobe with Jimmy Choo's sleek black leather thigh boots. Wear them to streamline a chunky-knit sweater dress, completing the look with opaques and a structured handbag.
Shown here with: Stella McCartney dress, Kelly Wearstler cuff, Isabel Marant ring, Wolford tights, Dolce & Gabbana bag.
- Jimmy Choo April thigh boots: black leather, heel measures approximately 125mm/ 5 inches with a 25mm/ 1 inch platform, elasticated insert at top of leg for ease of fit, almond toe. Pull on.
Product Code: 163851
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Product Code: 163851


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This Gif entitled test gif was created from the youtube video 2 years ago. It uses 18 frames per second and is displayed at 640px resolution. This animated image plays for 9 seconds, was built with high quality and an estimated weight of 20.59 MB for download. This animation was originally created from the Yamboo - Fiesta De La Noche video from 01:18 to 01:27.
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text:
Ubisoft Announcements Abound!
Splinter Cell and R.U.S.E. get delayed; Assassin's Creed gets multiplayer.
Ryan's Top 10 News Stories I Read Today and Thought They Might Be April Fools Jokes But It Turns Out They Weren't
When the default tone for blogs is snarky, it can be tough to tell when they're just kidding.
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Vivian Milroy
20,491pages onAdd New Page
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this wiki
Vivian Victor Ellis Milroy (born London, 3rd June 1917 - 2nd September 2009) directed 12 episodes of Coronation Street in 1961 and 1963. Other directing work for television includes episodes of Torchy the Battery Boy and Armchair Theatre . Before being a director Vivian had worked on production teams, been a producer, written scripts and been an actor in the late 1940s. In addition, he was also an author so several books including Alpine Partisan.
Episodes directed by Vivian MilroyEdit
1961 (4 episodes)
- Episode 78 (11th September 1961)
- Episode 79 (13th September 1961)
- Episode 86 (9th October 1961)
- Episode 87 (11th October 1961)
1963 (8 episodes)


text:
News By Tag
Industry News
News By Location
Industry News
Joystick Joy for Tablet Gamers
Tablet users can now take their gaming to the next level thanks to the Tablet Joystick, bringing extra precision and increased fun appeal to all suitable touchscreen-based games.
The lightweight, easy-to-attach Tablet Joystick is perfect for those who prefer the feel of a real joystick when gaming. For any tablet-owning gamers struggling with the use of touchscreen controls, it offers a genuine solution.
The Tablet Joystick works with thousands of different games apps and is compatible with any game featuring an on-screen control pad. Users simply run their choice of game, place the Tablet Joystick over the on-screen control pad and push down. There are no wires or batteries involved, making it one of the most user-friendly tablet accessories currently available.
Compatible with any iPad or Android tablet device, the Tablet Joystick is in stock now, ready for immediate dispatch. For further details, customers should log on to http://www.monsterstuff.co.uk or call 01509 266414 during office hours.
# # #
Retailer of the very latest novelty gifts and cutting edge gadgets, offering fast delivery and a huge range of products from funny and quirky gifts to cool technology and cutting edge gadgets.
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text:
Recently, branch support for Subversion was added to externals.
Subversion does not have a branch feature. Instead, subversion users use the copy feature to copy directories within the repository (branch), a switch command to switch the URL that the working directory points at (checkout), and a merge feature to merge directories (merge).
ext handles branches in Subversion by splitting the URL given by 'svn info' into a repository part and a branch part.
If you find yourself doing this:
ext checkout svn+ssh://someserver/somepath/repository/branches/new_feature
Then you almost certainly mean to do this:
ext checkout svn+ssh://someserver/somepath/repository -b branches/new_feature
For ext to use branch-related features with Subversion repositories, the repository must be known. For subprojects this is never a problem, but for the main project, it's important that there is a repository field under [.] in the .externals file. This can be accomplished by using -b with commands like 'ext checkout' and 'ext init' or by manually editing the .externals file.
For example, if you are working on svn+ssh://someserver/somepath/repository/current then you want your .externals file to look like this:
[.] scm = svn repository = svn+ssh://someserver/somepath/repository
Notice how I left off "/current" from the repository URL. "current" is the branch and not part of the repository from ext's perspective.
Powered by Typo – Thème Frédéric de Villamil | Photo Glenn


text:
About Your User Account
After you register, you will be able to use your user account for many purposes.
To log in, select in the top right-hand corner and enter your username and password. Your name will be displayed, and you can then access account items.
On the main account page, you will find your personal data and a summary of account options.
Payment system
The payment system allows you to manage funds for printing, reserving study rooms, or paying any possible late fees.
You can credit your account up to a maximum of CZK3500. You may need to keep a minimum balance of CZK15 to use some services (e.g., scanning using the print/scan/copy machines).
Payment options
Add money to your account:
- At the cash desk (ground floor)
- Pay online by credit card (online only)
- Use wire transfer:
Account number: 3932292/0800
Constant symbol:308
Variable symbol: 2222
Specific symbol: Customer ID (If you don't know this, ask us at a service desk.)
Reservation system
The reservation system allows you to reserve rooms for studying or teaching.
The interface is currently only in Czech, so we recommend you ask for assistance at a service desk.
Printing system
Use the Printing System to manage your print/scan/copy activities.
You'll find more information about how to print, scan or copy in this technical guide.
(+420) 232 002 535
See also
Add money to your account online
Library Space Rentals & Reservations
If you need help with our reservation system, please ask at a service desk or read the Tech Guide.


text:
Your stay in Adler's Hotel Flamingo
Sochi is one of the 5 Russian seaside resorts most popular with Russians as well as foreign guests.
This city's natural beauty, parks and beaches, high-class restaurants and accommodations, and warm sea and sun attract a great number of tourists. A 2012 summer vacation in Adler is a dream that can come true for anyone who wishes to take away incredible memories of this summer for life. The Black Sea coast in general, and Adler in particular, has truly earned the right to be called a tourist paradise. The sanatoriums and private hotels of Adler can accommodate all the tourists and guest of our city. In Adler you can find hotels ranging from small and cozy to huge, as well as whole recreational complexes, and local prices are surprisingly low.
Many tourists and travelers already know that this is a great place to improve your health or just have a good rest and recuperate.
Hotel Flamingo welcomes you!
The resort is ideal for those who wish to not only relax on Black Sea beaches, but also to enjoy incredibly exciting tours of numerous natural sights. Sochi is undoubtedly a city to fall in love with — no wonder the influx of people eager to spend their vacation here is noticeably increasing from year to year.
Taking a trip to wondrous mountain regions or enjoying outdoor activities on the sea shore will leave you with a lot of unforgettable impressions, colorful photos, and an endless sea of joy and excitement. The state-of-the-art Hotel Flamingo will help you to relax after a full day of outdoor activities and get ready to take new excursions and explore new lands – or crowded dance floors. Known for its coziness and comfort, the hotel offers its luxury rooms, equipped and fitted with everything needed for a carefree vacation, to guests from any corner of Russia or the world.
Hotel Flamingo's location in the heart of the resort makes transfers to the airport, train, and bus stations as quick and easy as it gets. We offer our guests a rich palette of activities: from sightseeing and walks in the parks and gardens of the city to an unforgettable time on the shore of the gentle Black Sea. It's worth noting that Hotel Flamingo has its own direct access to the shore, and its clean and comfortable beach is a mere 15 meters (49 feet) away.
You will be pleasantly surprised by the high-class service of Hotel Flamingo and its restaurant. The restaurant's incredibly rich menu, featuring dishes of Caucasus, European and Russian cuisine, will add to the overall great experience of your stay. Its relaxed and friendly atmosphere will make your vacation positive and harmonious.
The sea is far more than just the beach; you can find many more fun things to do here!
Your exciting stay will be spiced up even more by evening entertainment: fun and fiery entertainment shows won't let you get bored on a warm night by the seaside. Each and every hotel in the city strives to give their guests the most comfort and fun they can offer, trying to make sure they will come back — hence the plethora of entertainment in the city. Concert programs with the brightest Russian stars will complement your already vibrant and memorable stay in one of Russia's most beautiful cities. Adler's hotels and sanatoriums are ready to provide you with a great vacation experience in 2012.
The resort's beneficial climate and its medicinal muds and mineral waters can improve health for both adults and children. The multitude of available tours will give your vacation experience even more variety. When the fall comes, the resort is still bustling: the sea is still warm, and the wind and sunbeams still caress your skin like in summer. Our season of good times, with all its swimming and tanning, lasts until the end of October.


text:
Create a free account to check out faster, store multiple shipping addresses, view and track your orders in your account, and much more.
Please enter your password to continue.
We love silver and gold as much as the next gal, but there's something extraspecial about the pink-hued shade that's popping up all over the jewelry scene. This metallic rose gold lacquer from NYC fashion house RUFFIAN (available exclusively through Birchbox) applies like liquid metal, so your nails shine and shimmer as much as the rings and bracelets stacked on your hands and wrists. RUFFIAN polishes are specifically formulated to hold up for days without chipping, so you can wear this opulent shade nonstop.
ok so i wanted to love this nail polish so much. i'm a huge fan of weekly polish changes and i love rose gold, so i thought i was going to be in love. the polish is a cute color but once applied to my nails, it looked very trashy. also, the polish was not easy to apply and took several tries for it to go on smoothly. was not impressed and i definitely wouldn't spend money on a full-sized.3


text:
They top the university league tables and receive no end of media attention. But are Oxford and Cambridge all they're cracked up to be? And how hard is it to get a place to study there?
Plenty of Britain's top jobs are taken by Oxbridge graduates. Around 62% of high-flyers in the diplomatic service, 58% of those in the law, and 55% of those at the top of the civil service were educated there, according to research by the Sutton Trust. But this doesn't mean Oxbridge is necessarily the best place to study, says Stephen Isherwood of the Association of Graduate Recruiters.
"Lots of students decide that they'd prefer to go elsewhere because they prefer the course syllabus or because the institution is a specialist one. The musician Jamie Cullum, for example, rejected a place at Oxford to study at the University of Reading. You've got to think long and hard about the institution, the course and what you hope to get out of it."
And while an Oxbridge degree might sound impressive, it won't guarantee you a job. "There's no denying that Oxbridge have some really bright students, so they might be more targeted by employers. But talk to any recruiter and they'll tell you that they've turned down a fair number of Oxbridge candidates – just because you've been there it doesn't mean you can walk through the door."
If you do choose to apply there, the best advice is to ignore media stereotypes and "make sure you know why you really want to study the course you've chosen for the next three or four years", says Naina Bajekal, a student at New College, Oxford University. There isn't an Oxford type, agrees Mike Nicholson, head of undergraduate admissions at the university. "We're just interested in bright students who care passionately about their subject."
So how does the admissions process work?
Roughly speaking, Oxford and Cambridge receive just over five applications for each place. Candidates are shortlisted on the basis of their predicted A-level grades, GCSE marks, personal statement, school reference and any entrance tests or work submitted. Cambridge promises to interview "everyone who has a realistic chance of being offered a place, which is over 80% of applicants each year." At Oxford, 60% of those applying in October 2011 were invited to interview, with 35% receiving offers.
Of those students starting at Cambridge in September 2012, 83.1% achieved A*A*A or above (400+ Ucas points), counting only their best three A-Levels, and excluding general studies and critical thinking. Some 74.3% of those awarded a place at Oxford in 2012 achieved the same grades.
Both universities consider candidates' educational or social background when making offers. Oxford uses a "flagging" system to identify and support candidates who come from poorer neighborhoods or who have been in care, explains Nicholson.
"We get all the information about an application together – the Ucas form, aptitude tests and so on – and then if we've got candidates who have been given a contextual flag and we feel that we should interview them, even if they haven't done as well on the aptitude tests, we will interview them as well."
This policy does not disadvantage any non-flagged candidates, adds Nicholson. "Their place isn't being taken by someone who has a contextual flag, we're just interviewing some additional candidates."
Cambridge also consider candidates' academic record and predicted grade "in the context of the quality (but not type) of schools/colleges at which it was achieved."
The success rate of students varies across the board, but you can find details for each individual course, broken down by private and state schools, by searching the interactive below.
If you do decide to apply, you've got less than a week left to submit your application – the deadline is 15th October.
• The infographic shows Cambridge admission data for applications beginning in autumn 2011. The applicant and admission numbers for Oxford show rounded averages for a three-year period (2010-12). Success rates for the university's applicants are calculated using non-averaged figures from the same time period.


text:
Nabh Kanwal, located at (Nau-Abad) Majara Raja Sahib, was built in the honour of Raja Sahib, who is was a popular saint. The religious places associated with Nabh Kanwal are located in Jhingran and Rehpa villages.
Tell us what do you think of Nabh Kanwal
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text: Overview Discussion topics Recent activity Members 1–1 of 1 comment Ideas anyone? Posted by lovemay on November 18, 2010 Add reply Share Send to a fan or friend Short link: lovemay posted November 18, 2010 :D JUST UPDATED A NEWW STORY! I dont know where its going. ANY IDEAS?!?!?! POST ON MYY WALL :D!thanks! <3~MARY!! -2 below threshhold| click to expand comment Back to top


text:
OneRepublicTue, September 10, 2013 - 7:00 PMSanta Barbara Bowl in Santa Barbara, CA
We are sorry, the date for this event has already passed. This event took place on 9/10/2013. Click here to view upcoming events for OneRepublic.
Please continue to check back as additional tickets may become available for purchase at a later time.
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Have a question? Need help? Call us at 800.477.5285


text:
About Us
The Somerset Fuchsia and Pelargonium Society meets in Taunton to share an interest in growing fuchsias and pelargoniums. Meetings are fun, with talks and demonstrations.
Some members join because they like to exhibit; others want to pursue a hobby at home and hear interesting talks.
There are annual shows for members to exhibit in or, simply, enjoy.
Next Meeting
United Reformed Church Hall,
Paul Street,
Taunton TA1 3PF
Wednesday 26 April 2017 at 7.30pm.
Relaxed evening with Peter Waving and his fuchsias being grown for the show bench. An opportunity to ask questions.
Other Events
Clyst St Mary Village Hall, Clyst St Mary, Devon EX5 1AA
Sun 9 April 10am-4.30pm
Membership costs £12pa and gives free admission to meetings and shows.
New member's subscriptions run from the date of joining for the next calendar year.
To see if you would like to join the society, why not first come to a meeting? The cost for visitors is a nominal £3.