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The Thai phase III HIV vaccine trial's modest efficacy (VE 31.2% 95% CI 1.1, 51.2) represents the first demonstration that a vaccine can protect against HIV acquisition. Baseline variables of age, gender, marital status, and risk did not modify vaccine efficacy (VE). Here we explore behavioral risk and efficacy at 6 monthly intervals following vaccination.
Behavioral risk was assessed with a self-administered questionnaire every 6 months during trial participation. Both the acquisition endpoint and the early viral load endpoint are examined for interactions with risk status over time and temporal effects following vaccination.
Risk for HIV acquisition is low in each risk group, but the majority of participants reported higher-risk behavior at least once during the study (N= 9187, 58%). In post-hoc analyses, comparing those participants categorized as high or rising risk at least once during study follow-up versus those who maintained low or medium risk behavior as a time-varying covariate, the interaction of risk status and acquisition efficacy is significant (P = 0.010) with greater benefit in the lower risk individuals. VE appears to peak early with an estimate of cumulative VE = 60% through 12 months after initial vaccination (95% CI 22 –80%), and declines quickly. Vaccination did not appear to affect viral load in either early or late infections.
Future HIV vaccine trials must recognize potential interactions between challenge intensity and risk heterogeneity in the population and treatment effects. The regimen tested in the Thai phase III trial may benefit from extended immunization schedules.
The results of the Thai HIV vaccine trial, RV144, provide new hope that a vaccine to prevent acquisition of HIV infection is possible.1 While the observed efficacy was modest and insufficient to warrant licensure, RV 144 provides both insights and opportunities. The Thai trial had two salient, hypothesis-generating observations: 1) that efficacy appeared greater in participants at lower risk for HIV infection and 2) efficacy appeared maximal early and decreased with time. We have undertaken a detailed, post-hoc statistical exploration to determine whether we can gain further insight into these observations.
In contrast to prior HIV efficacy trials, RV 144 enrolled predominantly heterosexuals residing from a population with low prevalence of HIV.1 Most sexual encounters in RV 144 were unlikely to be associated with HIV transmission risk. Participants in well-defined high risk groups including sex workers, homosexual/bisexual men or injecting drug users represented a minority of the study population and accrued a minority of endpoint infections. The study was not designed to evaluate risk-stratified efficacy rates, and no statistically significant interaction between baseline risk and efficacy was observed1 although estimated VE was >40% in the lower risk groups at baseline and under 5% in the high risk participants. In other disease settings, sufficient challenge doses may overwhelm a vaccine induced protective immune response.2 Possibly, the modest success observed in RV 144 may be a reflection of generally lower levels of challenge encountered in the study population.
In general, non-human primate challenge studies with high dose, intravenous SIV and pathogenic SHIV have suggested that protection from infection was not feasible but a favorable modification of early viral burden and clinical outcome was realistically achievable.1 A notable outcome in RV 144 was the absence of an effect on viral load among vaccine recipients.1 Most of these non-human primate studies employed intravenous or non-physiologic, high-dose mucosal challenge doses of virus. Recent non-human primate challenge studies utilizing a repeat, low-dose, mucosal challenge with SIV after vaccination have shown protection from acquisition with no or variable effect on viral load or clinical outcome among animals with breakthrough infection.3, 4 These observations are consistent with the notion that currently available vaccines afford a reduction in acquisition risk that are observed in settings that more closely model human trans-mucosal risk. Taken together, these findings also suggest that the immune responses associated with protection from infection are largely distinct from those needed for reduction of viremia and improved clinical outcome as suggested in a summary of data from human trials of ALVAC-protein boost breakthrough infections and an SIV NHP challenge study.5–7
The RV 144 study was designed to acquire endpoints over 3.5 years after initial vaccination in over 16,000 volunteers with 90% statistical power to address the acquisition objective of 50% efficacy. This population size and extended follow-up was needed in view of the ten-fold reduction in HIV incidence as a consequence of the vigorous public health campaign for HIV/AIDS prevention in Thailand.8, 9 The trial was not designed to define time-dependent effects. Nevertheless, inspection of the data suggests that efficacy waned during the extended observation period although the interaction was not statistically significant.1
Here we further explore, in a ad-hoc analysis, the interaction of risk behavior and efficacy over the full course of the study and examine time dependent estimates of efficacy to guide the design of future VE trials for HIV.
The main study methods and results including the screening, enrollment and retention data by arm have been published previously.1 In brief, the trial was a randomized, multicenter, double-blind, placebo-controlled efficacy trial testing the combination of ALVAC-HIV® (vCP1521) and AIDSVAX B/E® to prevent HIV infection or reduce set-point viral load. Male and female volunteers aged 18–30 years were recruited from the community without regard to HIV risk through a separate screening protocol. Volunteers received a trial information briefing and written informed consent was obtained for participation in the screening protocol.HIV testing was performed, and a follow-up visit was scheduled 2–3 weeks later at one of the eight clinical research sites.
Volunteers returned for follow-up after the screening visit, were informed of their HIV test results and if seronegative, the Phase III trial written informed consent was obtained and vaccinations initiated. The protocol was reviewed and approved by the Ethical Committees of the Ministry of Public Health, the Royal Thai Army, Mahidol University, and the Human Subjects Research Review Board of the U.S. Army Medical Research and Materiel Command.
Vaccinations occurred over a 24-week period (0, 4, 12, 24 weeks). The ALVAC-HIV® (vCP1521) or placebo prime was given in the left arm at weeks 0, 4, 12, and 24. Boosting with AIDSVAX B/E or placebo was delivered in the right arm at weeks 12 and 24.
The volunteers were followed with HIV testing (with appropriate pre- and post-test counseling) every 6 months for 3 years. Plasma for HIV-1 diagnostics was collected at 0 and 24 weeks, and every 6 months during the follow-up phase. Education on risk behavior reduction was provided during each vaccination and post-test counseling visit. The scheme for clinical trial conduct from screening to treatment and analysis allocation is published elsewhere.1
Assessment of HIV risk behavior within the preceding 6 months occurred at baseline, week 24 and at each 6-month follow-up visit via a self-administered questionnaire. The volunteer was asked to categorize whether their everyday behavior placed them at risk for HIV infection. The questionnaire then inventoried specific risk behaviors for HIV acquisition. At each visit, a participant was categorized as "high risk" if in the last 6 months: (1) reported that their behavior placed them at risk for HIV, (2) shared needles when injecting drugs, (3) 2 or more sex partners; (4) HIV positive partner; (5) no condom use during the last sexual contact (≤ 6 months) with a commercial sex worker (CSW), casual partner, same gender partner, drug injecting partner or partner with multiple partners; (6) recent STD symptoms; (7) drug use while incarcerated; or (8) baseline employment as CSWs or in the entertainment industry. Volunteers were considered low risk if in the prior 6 months they: (1) perceived their behavior did not place them at risk for HIV; (2) reported 0/1 sex partners and no sex with CSWs, casual partners, same gender partner, HIV infected partner, drug-injecting partner or a partner with many partners; (3) or reported no STD symptoms or incarceration. The moderate risk category contained persons with neither low nor high risk. For example, an individual with a single partner described as CSW, IDU, same gender or casual partner but who used condoms at the last sexual encounter is neither high nor low risk and therefore categorized as medium risk. Also, individuals who did not answer a risk question item but were otherwise consistent with high risk were classified as moderate risk. The risk score categories were constructed from the baseline responses using the combined arm infection results in a blinded fashion. The terms high, moderate and low are relative within this population and do not equate to typical definitions in high-risk cohorts.
Volunteers with prevalent infection at baseline were excluded (N=7) and the modified intent-to-treat population was used for the analyses (N= 16395). To accommodate withdrawals, the percentages of individuals with identified risk characteristics over the study course were estimated by the product-limit survival method. Multiple proportional hazards regression models with treatment and time-varying risk covariates were analyzed. Because of its simplicity and similar VE results seen in subjects with initial low or medium risk, results for the time-varying covariate model with risk categorized as high or ever increasing (versus other) along with its interaction with treatment are presented. VE was also evaluated for maximum level of risk reported during the study and risk level reported in the study interval prior to seroconversion. VE estimates from the Kaplan-Meier infection estimates were computed at semiannual time points. A nonparametric estimate of the relative hazard function was computed along with its confidence intervals.10 Descriptive statistics were computed and pointwise Wilcoxon tests of viral load were performed. Two-tailed p-values are reported.
The study was funded by the US Army Medical Materiel Command and the Division of AIDS, National Institute of Allergy and Infectious Diseases. ALVAC-HIV (vCP1521) and ALVAC placebo was supplied by the manufacturer, Sanofi-Pasteur. AIDSVAX and AIDSVAX placebo (VaxGen) was purchased by DAIDS/NIAID for the purpose of this trial.
We previously reported that baseline behavioral risk characteristics were balanced by treatment arm and associated with different placebo arm transmission rates ranging from 0.227 per 100 PY in the low risk group to 0.364 in the high risk group (p=0.005 adjusted for treatment).1 However, estimates of VE were not significantly different when compared by the baseline behavioral risk co-variate or any other parameter assessed including sex, age, and baseline partnership status.1 Behavioral characteristics were evaluated at each subsequent visit and for the study overall; the percent of total participants categorized as low risk increased, and the medium and high risk categories declined through the first 52 weeks of study and remained stable thereafter (figure 1). The distribution of risk for both overall category and individual risk items (data not shown) between treatment arms remained balanced. Condom use was stable over the course of the study for all partner types. Overall risk behavior category was similar between men and women (data not shown).
Participants were able to skip a question or report, "don't know/not sure", and these response rates declined as the study progressed. For example, "declined to answer" for injecting drug use with needle sharing was 7.4 % (N=1218) of respondents at study entry and decreased to 2.0 % (N=303) by trial end with a small corresponding increase in reported rates both affirming and denying this behavior over time. Thirty five percent (N=105) of the participants who declined to answer at trial end also declined to answer this item at baseline. Although the rates for individual and overall risk category did not systematically increase over time, the number of individuals who reported a high risk factor at least once increased (table 1). No treatment group differences were identified in the risk categories at baseline or through time. At baseline, 7 of the 15 risk characteristics had higher numbers in the placebo group with a maximum excess risk disparity of 18 subjects. Many participants (N=5613 36%) reported a self-assessment of high-risk behavior at least once during the study. Generally, all other specific risk items were far less common. Taken together the percent of participants self categorized or assigned to the high risk group based on specific responses rose from 24.1% (N=3495) at entry to58.2% (N=9187) when considering all time points available in the study. The number of HIV infections in baseline high risk (N=45) and low risk participants (N=46) was similar despite different transmission rates because low risk participants were more common at baseline. However, over time the majority of infections were identified in participants who reported high-risk behavior at baseline or at least one subsequent visit. An additional 39 infections occurred in participants who initially reported low risk behavior (n=28, 14 placebo and 14 vaccine) or medium risk behavior (n=11, 6 placebo and 5 vaccine) and later reported at least one interval with a higher risk behavior category. When considering two categories of risk for the entire study data-set as those reporting high or increased risk behavior at least once versus those reporting medium or lower or constant low risk throughout the study on a time-varying basis, the interaction of risk with VE is significant (p = 0.010). The VE estimate for participants who maintained their low at entry or medium at entry risk throughout the entire study is 68% (p=0.002 95% CI (34%, 84%)). In this analysis, little vaccine effect is seen for the higher risk group (VE=5% 95% CI(−46%, 38%)).
Although this post-hoc analysis identifies an interaction with risk, the most important risk behaviors for HIV transmission globally contributed little to the observations within RV 144. For example, though injecting drug use with needle sharing was commonly reported (N=1250 8.2% overall) only 5 HIV infections were observed (2 vaccine and 3 placebo). Among men reporting sex with men, only 16 HIV infections were observed (8 vaccine and 8 placebo).
Over the course of the study, as shown in table 2, observed VE declined at each interval with endpoint ascertainment after 12 months but the interaction of time from first immunization and outcome was not significant (p=0.36).1 Nevertheless, the early time point efficacy estimates observed after completion of the vaccine series are substantially greater than at study conclusion with a VE of 54% and 60% at the 6 and 12 month intervals. The transmission rate for the placebo group varied modestly from 0.38 per 100PY in year one to 0.26 per 100PY in the final year of observation. In proportional hazards models that specified the log hazard ratio (vaccine/placebo) as various smooth functions of time (linear, log-linear, quadratic, piece-wise cubic polynomials in 3 or 4 segments), the results were generally consistent with efficacy most clearly evident early and declining from the second year of observation through study end (data not shown). A nonparametric analysis gives a similar result with early instantaneous hazards efficacy waning to zero by 18 months (figure 2).
In view of these observations, an additional post-hoc analysis considered a timing of infection and viral load. The viral load endpoint was determined as the average of three samples acquired over the first 6 weeks after serodiagnosis of HIV. This viral load endpoint was evaluated for acquisition events arising within 600 days of initial vaccination, a period with higher efficacy rate estimates, separately from those observed after this period where efficacy declined. No difference in viral load at any time point following infection, or mean early viral load (the co-primary endpoint), was detected for vaccine and placebo comparisons when segregating analysis by proximity to vaccination (figure 3A and 3B). Vaccine impact on viral load did not differ either by baseline risk group or when categorized as high or increased over baseline risk versus others.
The Thai phase III HIV vaccine trial showed modest benefit which was unrelated to baseline variables including risk assessment. The risk assessment variable is significant in respect to outcome when considered over the course of the study. Further, the efficacy estimate was highest in the first 6 months after completion of vaccination and waned rapidly.
Risk of infection is a complex, compound estimate of multiple effects but may be simply formulated as follows (adapted from Fisher et al.)11
Aggregate risk of infection is a function of donor "challenge" (risk that source is HIV positive, viral load, presence of co-factors, ie STD, bleeding and others), recipient susceptibility (genetically defined host characteristics, route and presence of cofactors, ie STD, bleeding and others) and frequency of exposure.
For example, HIV infection among individuals with deletions of CCR5 are uncommon, but given sufficient exposures, the cumulative probability of encountering a donor with X4 virus mitigates the protective benefit of this element of genetic resistance.12 Further, data from human vaccine and challenge experiments provide convincing evidence that induction of protective immunity can be overcome with a single sufficiently large challenge.2 In the case of non-human primate studies, it has long been considered likely that reproducible and efficient infectious challenge doses and routes may require a magnitude of immune response that is currently unachievable for the current generation of vaccines. Similarly in Vax003, a trial that utilized AIDSVAX B/E in Thai injecting drug users, the lack of observed efficacy may have been due to the stringency of intravenous challenge, when compared to intravaginal and intrarectal routes. This may be due to the circumvention of mucosal barriers and associated genetic bottlenecks or the avoidance of vaccine associated immune responses associated with mucosal sites. Several lines of evidence suggest that the challenge experienced by IDU is higher in magnitude and in genetic diversity.13–15 It is possible that the human vaccines tested in efficacy trials thus far provided only modest time-sensitive reduction in host susceptibility that was undone by the aggregate transmission challenge intensity, i.e. the product of the number and quality of host risk behaviors and susceptibility factors and the frequency and magnitude of exposures.
It is reasonable to assume that vaccine induced immune responses are independent of volunteer risk status. The absence of efficacy in higher risk participants within RV 144 may reflect either the higher challenge per exposure or more frequent exposure or both, with infection when the threshold exposure occurred at a time when immune responses were inadequate to the task of containment (figure 4). In contrast, the population maintaining lower risk throughout the study, in whom efficacy is observed, are likely to have less frequent exposures and possibly less challenging exposures. This concept is illustrated in figure 4. Frequency and route of exposure, and co-factors such as STDs, constitute the basis for considering different levels of challenge intensity16, 17 and correspondingly, different magnitudes of vaccine induced immunity required to achieve protection. Further, it can be deduced from figure 4, that vaccine-induced responses must be both higher in magnitude and better sustained to achieve similar efficacy in high intensity and low intensity challenge populations. The model depicted in figure 4 conforms to the observations of a modest, time-limited protective immune response as observed in RV 144 and suggests an additional boost or other augmentation of immune response would improve efficacy for all risk categories.
A second possibility assumes a more complex model with different immune responses that protect against higher and lower risk challenges (for instance, these might be manifest in different mucosal compartments); the differential decay of these protective responses could also explain the early protective effect seen in RV144. Correlation of immune responses induced by the ALVAC-HIV + AIDSVAX B/E regimen to the temporal pattern of protection will be critical in guiding future vaccine development.
The commonly held view has been that most vaccines under development for HIV had no hope of preventing acquisition of HIV infection due to the absence of neutralizing antibody.18, 19 It has been thought that a more realistic goal for vaccine platforms inducing T cell immunity was to reduce early viral load and slow disease progression as has been observed in high dose NHP challenge studies20–22 and inferred from studies of elite controllers and long-term non-progressors with HIV (reviewed in Virgin, et al.23). Despite the apparent absence of neutralizing antibody against primary HIV isolates or broadly neutralizing activity the ALVAC prime/AIDSVAX boost reduced acquisition by 31.2% at 42 months. This regimen failed to provide any early viral load benefit even when examined in the period shortly after vaccination, where acquisition efficacy appears highest. This observation is consistent with the notion that efficacy for acquisition requires a different set of immune effectors than achieving a reduction in viral load and altered prognosis. Interestingly, Haynes et al. reported that IgG against a conformational gp120 V1V2 epitope was inversely correlated with infection in RV144.24 These data prompted Barouch et al. to look for anti-V2 responses in non-human primates vaccinated with adenovirus type 26 and modified vacciniaankara vectored SIV inserts, and anti-(SIV)V2 responses in that study were also inversely correlated with infection risk.7 These findings raise additional hypotheses related to the potential decay of immune responses in the plasma or mucosal compartments.
One may reasonably question whether a vaccine affording modest protection in low challenge intensity settings is valuable as a public health intervention; others argue that such a vaccine might be cost effective in the Thai setting.25, 26 Nevertheless, the value of identifying the potential to protect from human transmission by vaccination cannot be underestimated. Further elucidating the nature of protection afforded in more permissive settings may allow optimization of vaccine strategies to achieve qualitatively and quantitatively superior products with expanded efficacy potential. The data presented here should be carefully considered in terms of the inherent risks of a post-hoc analysis and are intended to identify areas deserving further consideration in future efficacy trials. It is likely not the primary findings of RV 144 that are most important to future HIV vaccine development but the questions these data engender. Among these, the temporal nature of protection and the interaction with risk deserve more detailed consideration in HIV vaccine trials.
A systematic search of the literature for HIV vaccine efficacy trials was accomplished using PubMed to identify all randomized controlled trials with behavioral data and a positive outcome published in English. No prior studies of HIV vaccines showing any degree of efficacy were identified.
The efficacy observed in RV 144 which enrolled a low incidence population and benefit waned quickly after 12 months rapidly and accrued mainly to those who did not report or perceive traditional HIV risk behaviors. Future studies will need to employ designs to account for participant risk and temporal effects and this pox-protein prime boost regimen may show improved efficacy with extended boosts.
The study was funded by the US National Institutes of Health, Division of AIDS and by the US Army Medical Research and Material Command. The authors recognize the critical support and commitment of the volunteers, research staff and communities of Chonburi and Rayong where the study was conducted.
Funding: Funding was provided by the US Army, Research and Material Command, and the Division of AIDS, National Institutes of Allergy and Infectious Disease, NIH.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
AUTHOR CONTRIBUTIONS The manuscript was written by Merlin Robb, Jerome Kim, Don Stablein and Nelson Michael who also contributed to study design, management, and data analysis. Peter Gilbert contributed to data analysis and manuscript preparation. SupachaiRerks-Ngarm, SorachaiNitayaphan, PunneePitisuttithum, JaranitKaewkungwal, PrayuraKunasol, ChirasakKhamboonruang, PrasertThongcharoen, Patricia Morgan, Michael Benenson, Robert Paris, Joseph Chiu, and Elizabeth Adamscontributed to the design, execution, collection and analysis of primary trial data and risk information. Donald Francis, Sanjay Gurunathan, Jim Tartagliaare representatives of the manufacturers of the study test products and were involved in design, oversight, data analysis and interpretation.
The opinions in this paper are those of the authors and are not to be construed as official and do not reflect the views of the Department of Army or the Department of Defense.
CONFLICT OF INTEREST STATEMENT Sanjay Gurunathan and Jim Tartaglia are employees of Sanofi-Pasteur, the commercial manufacturer of ALVAC. The remaining authors have no conflict of interest.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Nice site!
I was just reading through thedrive.ca, trying out the different functions, and had to write to say how impressed I am with the way you've integrated the various press items on the Drive into the website's structure.
There's hardly a page where I didn't see some aspect of a press piece put to better use embedded in the site than it would as just an aspect of the Buzz on the Drive page.
Janna Sylvest, Womyns' Ware


text: WASHINGTON, April 10, 2013 /PRNewswire-USNewswire/ -- The Concord Coalition said today that President Obama's proposed budget for Fiscal Year 2014 provides a credible framework for the bipartisan negotiations that are needed to curb the growth of the federal debt over the next decade and beyond. Congress should consider the President's proposals through a House-Senate conference committee as it works on a joint budget resolution. "While elected officials have made some progress on deficit reduction in the last two years, much remains to be done to rein in the federal debt and ensure that the country is on a sustainable long-term path," said Robert L. Bixby, Concord's executive director. "The President deserves credit for political courage in proposing meaningful savings from entitlement programs, including Medicare, and new revenues from curbing government subsidies in the tax code." The Concord Coalition has long argued that a combination of entitlement and tax reform will be needed in any plan big enough to stabilize and gradually reduce the nation's debt-to-GDP ratio. The President's budget does a better job than either the House Republicans' blueprint or the Senate Democrats' plan in recognizing this political reality. The fact that the budget is already drawing criticism from both sides is an indication of its strength rather than weakness. If there is no package of mutual compromises, there can be no deal. Despite this, however, the President's budget would leave the debt-to-GDP ratio higher than either the House or Senate budget committee plans at the end of 10 years. A more ambitious target should be achievable through additional bipartisan negotiations. Many members of Congress have expressed theoretical support for the types of entitlement and tax reforms in the administration's budget -- thus its release will test the level of support in practice.


text: Download: Kafan ki Wapsi pdf in Hindi by Maulana Ilyas Attar Qadri December 8, 2015 Dawateislami, Hindi Books, Islamic Months, Maulana Ilyas Attar Qadri 114 Dislamicbooks.com is going to provide you with Kafan ki Wapsi in Hindi to Download in pdf. The book is a product of Dawateislami, published by Maktaba-Tul-Madinah and written by Maulana Ilyas Attar Qadri, a renowned Islamic scholar. Download: Facebook Twitter Google+ Pinterest LinkedIn Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Website


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Download document:
OTC derivatives after the introduction of EMIR - .PDF file.
With certain aspects of the regulation on OTC derivatives, central counterparties and trade repositories (EU) 648/2012 now in force, Sam Robinson, senior associate at Nabarro, who advises on UK and EU financial services law and regulation, considers the impact of the European Markets Infrastructure Regulation (EMIR) on the industry.
With the changes that are proposed by EMIR, the proposed timeframe is clearly ambitious. This is the case even after taking into account that EMIR is being implemented on a staged basis, allowing the regulators and the industry more time to prepare for arguably the more demanding changes that will be brought in with the new regime. For example, one change that is likely to prove problematic is the requirement to provide colla-teral for trades that are not centrally cleared, which is expected to enter into force in late 2014/15…
If you are registered and logged in to the site, click on the link below to read the rest of the Nabarro briefing. If not, please register or sign in with your details below.


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Originally posted on Fox Sports Southwest | Last updated 4/7/13
Probably in the past, you recruited football players by talking to them about your program and their opportunity to play in it. You'd tell the mom about the academic opportunities. You'd take them around campus and make sure they saw all the pretty girls. You'd show them the trophy case. That is of a bygone era. You know what you need now? A DJ. Friday night, Texas A&M coach Kevin Sumlin brought a DJ to Kyle Field to spin records at a recruiting event the Aggies call "Friday Night Lights." Yeah, DJ Double R started spinning from inside the trailer of an 18-wheeler, dazzling about 35 recruits from the classes of 2014 and 2015, according to the San Antonio Express News. And the the Aggies had a scrimmage. The idea behind it is twofold. Sumlin is trying to impress recruits, but he is also trying to break up the monotony of spring practice for players who are already in the program. Turning it into a scrimmage and playing it at night turns it into something of an event, and the players seem to like it. "'Friday Night Lights' is where I earned my starting spot last year," receiver Mike Evans told the Express News.
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Here's this week's crop of blog carnivals:
Bio::Blogs #15
Boneyard #6
Carnival of the Blue V
Carnival of the Green # 97
Circus of the Spineless #25
Festival of the Trees #16
Friday Ark #158
Grand Rounds (on a really fun Dr. Seuss theme!)
Tangled Bank 89
And look for Philosophia Naturalis #14 at The Dynamics of Cats on Thursday — it's a special date, so the carnival promises to be a good one. And… um… you might want to check back here for a few items as well.
Happy reading!
Technorati Tags: biology, blogging, climate, communicating science, evolution, fossil, paleontology, science


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Discussion in 'Draft Zone' started by KD, Apr 4, 2006.
Doesn't really impact the Cowboys in any way. We might gets calls if he is still available at 18 to see if we want to trade down. I hope he does go before we pick to push everyone down another spot.
I agree bd.......
If he's as out of shape as reported he'll be lucky to be a first rounder.
I read that also......he better quit looking at his reviews.....and hit the gym
So what you're saying is that if he's available at 18 we'll get trade solicitations and that if he goes before 18 we'll have potential draftees bumped down to us. So, how does that not really impact us?
One of my coworkers went to USC and he said he always plumps up during his offseason.
Well this offseason there are millions of dollars at stake. If that doesn't get him motivated what can?
He was on NFL Network yesterday. Of course he got asked about his poor performance. He tried to play it off like it was no big deal. He claimed his hamstring acted up and his whole body got tight. He couldn't run, jump or lift after that. "Teams know what I can do" he explained. I'm glad we are not in the market for a RB.
We don't need a RB. If his stock is up or down it doesn't really matter all that much.
If his stock was high a few teams might be interested in him that are right in front of us, namely the Vikings and Broncos. As it is we should be sitting at #18 with 3 of the top 4 Rb's available.
This would allow us to trade down with team in need of a RB such as the Panthers, Steelers or Colts. A trade down would net us an extra pick in the 2nd as well as a late round pick. I am sure Parcells would like extra picks in such a deep draft especially with none in the 4th.
Not after his pro day.
Disagree, it impacts us in a positive way if someone picks White before #18, it gives us a better chance for the player we want to slip to us........:starspin


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The Contribution Of Human Capital To China'S Economic Growth
This paper develops a human capital measure in the sense of Schultz [Schultz, T. W. 1960. "Capital Formation by Education." Journal of Political Economy, 68: 571, University of Chicago Press.] and uses this to reevaluate the contribution of human capital to China's economic growth rather than relying on years of schooling as in current literature. The results indicate that human capital plays an important role in China's economic growth, 38.1% of economic growth over 1978–2008, and even higher for 1999–2008. In addition, because human capital formation accelerated following major educational expansion increases after 1999 (college enrollment in China increased nearly fivefold between 1997 and 2007) while growth rates of Gross domestic product (GDP) are little changed over the period after 1999, total factor productivity (TFP) increases fall if human capital is used in growth accounting as we suggest. TFP, by our calculations, contributes 16.92% of growth between 1978 and 2008, but this contribution falls sharply between 1999 and 2008. TFP growth estimates along with the high contribution of physical and human capital to economic growth seem to suggest that there could have been decreases in the efficiency of input usage in China or worsened misallocation of physical and human capital in recent years. These results underscore the importance of efficient use of human capital, as well as the volume of human capital creation, in China's growth strategy.
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Volume (Year): 02 (2013)
Issue (Month): 01 ()
Pages: 1-22
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Yuqing Xing, 2011. "China's High-tech Exports: Myth and Reality," GRIPS Discussion Papers 11-05, National Graduate Institute for Policy Studies.
- Yan Wang & Yudong Yao, 2001. "Sources of China's economic growth, 1952-99 : incorporating human capital accumulation," Policy Research Working Paper Series 2650, The World Bank.
- Gregory C. Chow, 1993. "Capital Formation and Economic Growth in China," The Quarterly Journal of Economics, Oxford University Press, vol. 108(3), pages 809-842.
- Gemmell, Norman, 1996.
"Evaluating the Impacts of Human Capital Stocks and Accumulation on Economic Growth: Some New Evidence,"
Oxford Bulletin of Economics and Statistics,
Department of Economics, University of Oxford, vol. 58(1), pages 9-28, February.
- Norman Gemmell,, "undated". "Evaluating the Impacts of Human Capital Stocks and Accumulation on Economic Growth: Some New Evidence," Discussion Papers 95/17, University of Nottingham, CREDIT.
- Yao Amber Li & John Whalley & Shunming Zhang & Xiliang Zhao, 2011. "The Higher Educational Transformation of China and Its Global Implications," The World Economy, Wiley Blackwell, vol. 34(4), pages 516-545, 04.
- Yao Li & John Whalley & Shunming Zhang & Xiliang Zhao, 2008. "The Higher Educational Transformation of China and Its Global Implications," NBER Working Papers 13849, National Bureau of Economic Research, Inc.
- Douglas Gollin, 2002. "Getting Income Shares Right," Journal of Political Economy, University of Chicago Press, vol. 110(2), pages 458-474, April.
- Douglas Gollin, 2001. "Getting Income Shares Right," Department of Economics Working Papers 2001-11, Department of Economics, Williams College.
- Theodore W. Schultz, 1960. "Capital Formation by Education," Journal of Political Economy, University of Chicago Press, vol. 68, pages 571-571. Full references (including those not matched with items on IDEAS)
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Carolyn Lavers -- Water Shortage in port au Choix
Despite the rain during the past week or so, Port Au Choix still struggles with low water levels. Last week, the Town put out a call for residents to conserve water as much as possible.
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text:
Home > Healthy Holiday Recipe > Koullourakia
Happy Healthy Holidays!
These cookies are closely associated with Easter in Greece, another of the Greek paschal traditions that include dyed red eggs that are given to friends and family. In some villages the blanched almonds are replaced by sesame seeds.
Recipe Ingredients
1 cup butter, softened
2 tablespoons shortening
1/4 cup oil
1 cup sugar
1/4 cup orange juice
1 teaspoon vanilla extract
3 large eggs
4-plus cups flour
2 teaspoons baking powder
1/2 teaspoon baking soda
Milk and sesame seeds
Recipe Directions
Cream butter, shortening, oil and sugar. Add orange juice and vanilla. Gradually beat in eggs until light and fluffy.
Mix flour with baking powder and soda and add to butter mixture. Dough should be soft and pliable. Chill 2 hours.
Roll into small twists and swirls. Place on baking sheets. Brush with milk and sprinkle with sesame seeds.
Bake Greek Easter Cookies at 350 degrees until golden brown.
Variation: Sesame Greek Easter Cookies
Traditional Greek cookies are two small strands of dough twisted together and brushed with egg-milk mixture and sprinkled with sesame seed.
1 cup butter
1-1/2 cups sugar
4 eggs
1/2 cup orange juice
6 cups flour
1/2 teaspoon baking soda
2 teaspoons baking powder
1 egg, beaten (mixed with the milk)
7 tablespoons milk
Cream butter. Add sugar gradually. Add eggs one at a time alternately with orange juice.
Add flour that has been sifted with soda and baking powder, a little bit at a time. Should be a soft dough. Shape as desired and brush with egg and milk mixture. Traditional Greek cookies are 2 small strands of dough twisted together and brushed with egg-milk mixture and sprinkled with sesame seed.
Use greased cookie sheet. Bake at 375-degrees to 400-degrees for 10 to 12 minutes.
You may also like...
Easter Lore
The Greeks dye their Easter Eggs red to symbolize and honor the blood of Christ, while those in Germany and Austria, traditionally give green eggs on Maundy (or Holy) Thursday -- the day commemorating Christ's Last Supper.


text:
Remember Me
DJ Register - Free Sign UpÃÂ |ÃÂ Forgot Password
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Party planning is stressful enough on its own. Don't let booking your entertainment add to your burden. Follow these tips and you're guaranteed to book the very best in party entertainment!
Copyright © 1997-2017 1-800-DISC JOCKEY, LLC | Find A wedding dj | Privacy Policy | Terms of Use


text:
They were in the Scary Clown Bus. Now that there's recharged batteries back in the camera, there's no stopping me. Yep, also found the charger for the smaller batteries.
Here we have my Sacred Altar of Relaxation. This tub is from the old farm house we got with our property in Ohio. Yes, we moved it the 600-some miles up here. It's like a favorite pair of jeans - fits perfect, super comfortable. I have missed this tub. A lot. The house we built at the farm in Ohio came with one of those water wasting, no place is comfortable to sit in, corner garden tubs. I hate it. After four years of showers only, longing for a relaxing soak, a woman and her tub were reunited. As you'll recall, I filled my tub early yesterday afternoon and let the water heat up all day under the sun. The sun was going down by the time I was able to hop in. It was a little cool but not bad. It actually felt good after the sweltering heat. The fun thing about an outdoor bathtub is that one can really flop and splash around like a happy fish without worrying about getting water all over the place. I was so busy being a happy fish that I didn't notice the shapes where there shouldn't have been any. When you're in a bit of a hurry, you have to knock your glasses over and get water all over them before you actually get them on your face. Schew. I could tell through the distorting streams of water on my lenses it was just a couple of deer. How awesome is that? Taking a bath outside surrounded by trees and wildlife. Ahhhh. Home Sweet Tub.


text:
Are you looking for a business opportunity that you can do from your Home ? Do you want
to earn extra income by working in spare time ? Do you have little Internet knowledge ?
If your answer is yes, then you have come to the right place. Work without leaving your
present job.
Contact : Urmila Senthilkumar
Email : firstname.lastname@example.com


text:
Need a CRP Blood Test in Hopewell, VA? Simply order online 24/7 and get a fast, affordable CRP Blood Test at a lab near you (Find More Locations):
Why would I get a CRP Blood Test?
A CRP Blood Test is a blood test that checks the CRP level. People in Hopewell, VA get a CRP Blood Test at the request of a medical provider or for general tracking.
How much does a CRP Blood Test cost?
Our CRP Blood Test price includes the doctor's order that you need to get tested in Hopewell, VA, all lab fees and taxes, and a pdf copy of your results. For current prices, CLICK HERE.
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text:
ED Magedson – Founder
Ripoff Report
Numerological Recource CenterP O Box 868 Lynbrook NY, Select State/Province USA
Numerological Recource Center Analysis Division Says I am to be rewarded$2.350 million dollars for David Lennerth New Life Winne Mr Gerald St. John says Look in the mirror Smile and wave to the "New Life Winner". Lynbrook NY
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Well lucky for me I checked Rip Off Report first so I didn't lose $25 USD Thank you R P Report!!!
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text:
Days on the Market Property
|It has been suggested that this article be merged into Days on market. (Discuss) Proposed since February 2016.
This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages)(Learn how and when to remove this template message)
Days on the Market Property (DOMP) is a measurement in days of how long that a home has been listed for sale to the public on the MLS (Multiple Listing Service). Although much lesser known than the phrase "days on the market" DOMM, DOMP is directly associated with DOMM, which is the acronym that home buyers are most familiar with. The days on the market statistic is of interest when a person is valuing real estate for the purpose of comparison. More days on the market than average may indicate a listing that was overpriced. The other use for this statistic is allowing prospective home sellers an idea of how long it may take to sell a property. The MLS is controlled by the real estate industry and has been the subject of many lawsuits.
DOM-M stands for Days on the Market- MLS. Or the number of days this exact MLS listing has been on the market (not the home, but the MLS#).
DOM-P stands for Days on the Market- Property. So regardless of the number of different Realtors, it shows the number of days the property has been for sale.
Sometimes a property might be 83 days with one Realtor, and then 10 days with another. That would show up as: DOMP/DOMM= 93/10 Some realtors will try to fudge this data to make a listing look brand new.
Housing bubble[edit]
Prior to the historic housing bubble that formed in or around 2001 due to loose credit and irrational exuberance, the term DOMP was practically a mystery to anyone other than real estate industry insiders.
When the Housing Bubble began to rapidly deflate in late 2005, the inventory of homes for sale exploded, which caused both sales and prices to fall well below levels predicted by leading economists. These economists were frequently separated into varying levels of respect depending on their affiliation with the REIC, because the National Association of Realtors (NAR) economists were caught giving incorrect predictions about the state of the housing market despite what was actually happening in many U.S cities.[citation needed]
Manipulating DOMP[edit]
To prop up rapidly falling sales, real estate agents across the country began to rely on the process of manipulating the amount of time that homes had been on the market more than ever to attract buyers and maintain sales prices. There were great disparities concerning the practice in the various regional MLS's across the country. Some MLS's charged real estate agents to alter the statistics,[citation needed] and referred to the practice as "refreshing a listing." In general however, the old guard of the real estate industry considered the practice as deceptive at best, and fraudulent at worst. Rumors of possible lawsuits circulated in the industry because homes that had been on the market for long periods of time were considered to be overpriced and thus not worth their advertised sales prices. The practice also stood in dark contrast to the National Association of Realtor's Code of Ethics that prohibits doing anything that is deceptive to buyers.[1]
Current use[edit]
This business practice is still being carried out by the REIC and is a point of contention with bloggers calling it "deceptive".[citation needed] Others maintain it is a way to acquire the attention of new customers, akin to a store moving its inventory from one location to another. MLS information like days on the market, the selling price and who were the buying agents or buyers is not available in Canada to any-one but REALTORSr.


text:
Town House for sale in El Oasis Club, Marbella Golden Mile, with 1 bedrooms, 1 bathrooms and has a swimming pool (Communal) and a garage (Communal). Regarding property dimensions, it has 80 m² built, 15 m² terrace. This property, with orientation S/W, has the following facilities: Fully fitted kitchen, Fireplace, Satellite TV, Front line beach, Alarm, Living room, Gated community, Glass Doors, Close to shops, Close to port, Sea view, Transport near, Fitted wardrobes, Air conditioning, Good condition, Marble floors, Private terrace, Covered terrace and Amenities near.
We can help you to get a mortgage on favourable terms. A residence permit can be obtained with the purchase of this property. Please ask our team for more information.


text: Remanufactured Water Pump for 1967-1968 390, 427 & 428The enemy of an internal combustion engine is heat. If your coolant needle is creeping past it's happy place, you need to look at ways to bring it back down.These water pumps are remanufactured to OEM specs using modern materials and techniques. R & R for a water pump is a fairly simple job. Don't put it off 'till it's too late!Includes gasket.Related Parts:-Water Pump, 390 & 428, 1969-1970, #58208-Thermostat, 190 Degrees, 390/427/428, 1967-1970, #RT1155-Water Pump Bolt Kit, 3"90 & 428, 1967-1970, #WP497


text:
You are currently using an unsupported web browser.
We support the latest versions of these browsers:
If you have any problems while attempting to download a browser, you should contact your organization's system administrator.
For any questions related to Cvent, feel free to contact our Customer Care team.
Madeira Panoramico Hotel is located at Rua Estados Unidos Da America, 34 in Funchal. It lives up to its name, affording fantastic views over the bay. We have 132 guest rooms available to accommodate your stay here. We also have meeting rooms available for private and corporate hire to host your nex...
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text:
Visalus Shake is a unique blend of proteins for fast and long-lasting hunger control. With low carbohydrates and sodium, aminogen for maximum protein absorption, and pre-biotic for digestive health, this shake mix proves to be a very nutritional drink. Visit visalus.com for more information.
I have been buying these for years and I recommend them. They mix well and really do taste like vanilla cake mix. I usually drink mine with water or almond milk. I didnt find they helped with weight loss but that was not really why I was drinking them. Great mix for breakfast smoothie. I priced the serving size and compared to ready made shakes and it really is a comparable cost but tastes better than anything I have tried.
I was on the Visalus shake for about 3 months.
I liked the taste at first but I got very sick of it. VERY quick.
It didn't make me feel full either. It was just added
calories because I still felt hungry in the morning if
I didn't eat breakfast with it.
I did like it as a quick meal before the gym.
But... I couldn't find enough flavor combinations to
satisfy me.
It did keep me regular though. That was the only benefit
I noticed.
I am a vegetarian so I use this shake mix as a supplement / protein powder. This is the best tasting kind I have tried. I love that it tastes creamy and kind of like a cake mix (but not sweet) it blends exceptionally well. You can't taste it in a shake like most protein powders which is great. The nutritional benefits are awesome
I mix the Visalus powder with some frozen fruit, ice and almond milk. The shake is creamy and delicious. I find they are filling and when I eat healthy I do lose weight. The only con is the price. I've bought mine on eBay which has been much cheaper.
Great tasting shakes, smooth and creamy. They are expensive, and then you have to pay for shipping on top of that. I did not find their web very user friendly and I ran into a lot of issues that were never resolved with the 90 day challenge. Customer service was poor. Love the product, but price and customer service bring down the value of it.
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


text:
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text:
I would like to know if there is a way that I can either run a spiceworks report to see which users are currently logged on to what machine or if there is an AD thing which can show me?
I have a problem with one of my sys admins, he keeps leaving the bloomin admin account logged on somewhere when he is fixing something then gets called away or something!!
4 Replies
Oct 23, 2010 at 9:13 UTC
Download pstools from here
In a cmd window run "psloggedon \\computername" for a complete list of who is logged on directly or connected to resources.
Oct 23, 2010 at 9:55 UTC
Will that do it for every machine accross the domain?
So like I want to see which computers DOMAIN\Administrator is logged onto... will that do that for me?
Oct 25, 2010 at 3:54 UTC
Running "psloggedon administrator" will scan all your network neighborhood and show you each computer this user is logged on to.
Oct 25, 2010 at 4:11 UTC
Thanks very much guys!


text: I grabed a shotgun and ran.The living dead were after me.Am I insane?Zombies are attacking.That can't be.The dead are trying to kill me.But as I wonder if i'm halucenating a zombie bites me.I feel a rush of the virus taking over my body.I got up.I'm dead.But I walk.My body moves out.But suddenly I sence gunshots.My new instincs are to eliminate the zombie hunters.I walk north twoard the gunshots.SLAM!A cage falls on me.A helicopter has dropped it.The helicopter lifts me up.I grunt(that is about all the virus can make me say.About a hour later the helicopter lands on a nuclear carrier.My cage is transported to a white room.The man near me looks at me."you sure this thing is a man who had a reversible immune system" the man askes."yes sir"."Alright stap him to a bed."I am draged to a bed,I try to bite the men.Seconds later my vision went blurry."Lets hope this works" are the last words I here.


text:
Oslo University Hospital, Rikshospitalet, Oslo, Norway
PURPOSE: Lung carcinoids are rare, low grade malignant tumors. The "gold standard" treatment is surgical lung resection. Some authors support bronchoscopic treatment with a curative intent in selected carcinoid patients. We report our experience with endoscopic laser resection of endobronchial carcinoids.
METHODS: We included 25 patients (12 men and 13 women) with endobronchial carcinoids, treated with Nd:YAG laser with a curative intent at the Interventional Center, Rikshospitalet from 1998 to 2009. Median age was 39 years, range 23 - 80, median follow-up period was 3.5 years (range 1-11).
RESULTS: In total, 35 laser procedures were performed, 16 patients received only one procedure. Eleven patients (34%) were subsequently operated with lung resections (6 lobectomies, 4 bilobectomies, 1 pneumonectomy) due to suspected residual extrabronchial tumor tissue. In 3 of these patients no malignant tissue was detected in the resected lungs. All patients were yearly followed with bronchoscopy and CT thorax. All of them were alive and without malignant disease at the end of the observation period.One intraoperative complication was registered. Endobronchial combustion led to airway scarring and severe obstruction that caused recurrent lung infections. After repeated laser and balloon dilatation procedures the lung function improved to FEV1 74% predicted, and the lung infections subsided.
CONCLUSION: Endobronchial laser procedures are safe and complications are rare.
CLINICAL IMPLICATIONS: Selected patients with endobronchial carcinoids can be treated with laser ablation with a curative intent, although a significant proportion of the patients still require subsequent surgery.
DISCLOSURE: Kirill Neyman, No Financial Disclosure Information; No Product/Research Disclosure Information
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China Huishan Dairy stock falls on first day of Hong Kong trading
China Huishan Dairy, a mainland milk producer backed by billionaire Cheng Yu-tung, fell on its first day of trading yesterday. The poor debut casts a shadow on listing hopefuls in Hong Kong, likely adding to investors' reluctance to pay a decent valuation on future offerings.
Huishan Dairy was one of the city's best-priced initial public offerings this year, with its listing priced at the top of the marketed range. The stock fell 3 per cent from its offer price of HK$2.67, as the Hang Seng Index gained 0.4 per cent.
The company's pricing at the top end was too aggressive as Hong Kong's IPO market has not fully recovered, said Ronald Wan, the chief China adviser at Asian Capital (HK).
"The high-end price makes it less attractive to investors, who may be waiting on the sidelines for lower valuations," said Wan. "The market is not stable yet and there are no sure-win IPOs."
David Chin, head of Investment Banking Department for Asia at UBS who led the Huishan listing, said such a decline was normal amid volatile market conditions and expects future listings to be unaffected.
Chin expects Hong Kong to see at least a dozen listings worth between US$5 billion and US$7 billion over the rest of the year. These would come from businesses as diverse as pawnshops, health care and non-traditional financial industries, he said.
The value of Hong Kong offerings has reached US$7.8 billion this year, poised to surpass the US$8 billion for all of last year. The value is still far below the US$20 billion in 2011, according to data compiled by Bloomberg.
The company had offered shares at HK$2.28 to HK$2.67 each as it and investors sold at least HK$10 billion of stock. Huishan was established in 2009 as a raw milk producer, and has moved into the business of selling liquid milk and milk powder products, grain processing and trading.
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|600 sq. ft.
|Property type
|Minimum Stay
|4 nights
A freshly cleaned and updated charming deep water rustic cottage, with a nice sandy beach, and a 100ft. deep water dock. So, bring your sailboat or powerboat, or simply use one of our kayaks! Sit on the dock with a cocktail as the sun disappears into the ocean directly in front of you. Located next to a lobster wharf, where you can pick up fresh Maine lobster directly from the boats!! It really doesn't get any better than this!!
I would not recommend this property, nor would I return.
My husband and I enjoyed our stay in Jeff's cottage very much. We felt dropped down into an active real-life, working, lobsterman's bay. We enjoyed the view of the water and the gentle rumble of boats coming and going. I loved the smell of the ocean and the sounds of the seagulls. We enjoyed some of the freshest lobster possible from "our" neighbors! We kayaked all over the place!
The cottage is rustic but very quaint and adequate! We used the fireplace every morning and evening. We walked the pier out over the water a couple times every day. We used the big pot available to cook the lobsters. The only drawback is the heated well-water smells strongly of sulfur as mentioned in another review so although unpleasant, we were not surprised. The affordable price to be in this beautiful spot was worth it to us! We would love to come back! In fact, we dreamed of moving to Maine!
When we first arrived- it was very cold. This cottage is not insulated, and the heat had not been turned on- and there was not any firewood for the fireplace. So we had to build a small fire with just paper to knock off the chill. However, after that night- we bought some firewood- and it was perfect. The cottage is small, and cozy- but the view is worth a million dollars! The water in the bathroom- sink and shower- smelled of sulfur, so it took a little while to get used to, but it was not horrible. The neighbors had a dog- an Irish setter, who we fell in love with!! I would go back in a heart beat! Just make sure to buy firewood before going to cabin for night if it is chilly! I would love to buy the place. I could live there year round!!
We came to Maine with Charlie, our dog, to go hiking and geocaching for the long weekend. The New England coast use to be covered with these rustic summer cottages, and they are so few remaining for those of us who remember vacation rentals as simple cabins without cable TV, temperpedic mattresses and granite counter tops. It is well stocked with kitchen stuff, nice linens, plenty of towels and blankets... Jeff dropped off firewood and turned the lights on for our arrival and we picked up fried clams at the take-out fish shack on the way in since we got there too late to shop. (So good!). The hot water does smell like sulfur, but I didn't mind since hard water leaves skin and hair really soft. Charlie made lots of dog friends from the neighborhood, one showing up to play in the yard with a fish hanging out of his mouth. The TV seemed to work fine, but the only thing we wanted to watch was the Pats game, which was not covered by the DISH service. It didn't matter to us, we sat by the fireplace listening to in on the radio while logging in all the geocaches we got that day (14). And the Pat's won. This was a very quiet peninsula compared to touristy ones like Boothbay, there are no crowed streets lined with shops and restaurant. But if you like quiet, nature, great views of boats and sunsets from the long pier, the sounds of the harbor and seagulls, and friendly neighbors who will sell you lobster caught that day, this spot is quiet and beautiful. This place is, in our opinion, perfect just the way it is.
This house is perfect if you just want to relax and listen to the seagulls. Comfortable furniture, clean all around, everything working but the television, great neighbors, all the apples, pears and plums you could ever want right off the trees. Cottage is absolutely as advertised
Friendship, Maine is what is says in the name...a quiet little town with awesome neighbors who help you get lobster right off the boat. The yard out front is wonderful and the view is great. We did have numerous issues that would cause us to not book this property again and suggest others to be weary. The first issue was booking this place with a queen sized bed that is listed. After the lackluster review before me, I contacted the owner to confirm. He stated it was "either a full or a queen." When we arrived, it was indeed a full (and horrible mattress). We ended up sleeping separately on the twin sized beds on our vacation. Major issue #2 was that we confirmed multiple times that there would be kayaks available for use. We have a tandem kayak of our own we could have brought, but was assured there would be kayaks (plural). When we arrived we saw one kayak on the lawn and to the left multiple kayaks with a sign that said they belonged to the dock. We confirmed with the dock that they were indeed not ours and we were unable to kayak together unless we rented another one. So much for paying for an amenity that was listed yet not there. While I understand the cottage is next to the ocean and runs on well water, the water in the shower smelled of so much sulfur that it engulfed the home when turned on. We tried running the water to see if it would go away and it never did. We felt dirty taking a shower and could not even enjoy a nice warm shower on vacation. The television listed goes in and out, and multiple lights were not in working order. Beware if you have children, because the front of the home on the interior is all exposed nails. We have stayed in little homey cottages and a little dust, exposed wire or not the best of mattresses would have been fine for the cost. However, the deep lying about what would be at the cottage made the stay less than desirable for us. Finally, to top this all off, good luck trying to get in touch with the property owner. Took us 3 e-mail requests, multiple phone calls to a number with a full mailbox and a case number with VRBO to finally get our check in information the week of the trip. The property is currently for sale and they must just not want to put any money or effort into it while we are paying to rent it.
|Rate Period
|Weekend Night
|Monthly *
My Standard Rate
4 night minimum stay
|Tax Rate
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.


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Best Of :: Arts & Entertainment
It's like a full-scale ninja battle on stage: eight sweaty freaks brandishing guitars, horns, tambourines, microphones, pheromones, feedback and blood as they eviscerate everything that is decent and respectable about rock and roll. The band is Call Sign Cobra; that wet splat hitting your underpants is what's left of your spleen. With players culled from Scott Baio Army, Out on Bail, Mustangs and Madras, Rabbit Fight and Pariah Caste, Call Sign leaves no eardrum unscarred in its attempt to force-feed Rocket From the Crypt into Molly Hatchet -- and, of course, cement its position as the most blistering, organ-engorging live act in Denver.
The action can get pretty hot and heavy when LoDo's bars let out at 2 a.m. But from the cheap seats on the sidelines, watching the crowds pour out of the clubs and pour themselves into cars and cabs -- after some last-second attempts to hook up --can be mighty entertaining. And the vehicles parading slowly past offer a non-stop urban soundtrack.
Though Stevyn Prothero's tiny Iron Feather Book & Zine Shop is in danger of losing its space in north Denver, the place's do-it-yourself attitude lives on to the bitter end. Prothero welcomes any and all wannabe zinesters to use his stuff -- Xerox, keyboard, scissors and so on -- to create their own page for the community-based Open Zine Project. Prothero knows something about what it takes to create an indie publication: His own Iron Feather Journal has been coming out sporadically for years. Open your mind and take up your pen.
Capitol Hill encompasses a wide swath of central Denver, so it's no wonder that the Capitol Hill People's Fair is the city's best, and most diverse, festival. From its humble beginnings at Morey Junior High in 1971, when 2,000 people attended, the People's Fair has exploded into Colorado's premier arts-and-crafts happening; last year, some 275,000 people attended the three-day event at Civic Center Park, soaking up live entertainment, food by the barrelful, community and family-oriented activities and the best people-watching of the year. The fest is a huge fundraiser, as well: Capitol Hill United Neighborhoods raised $45,000 for area nonprofits in 2004. Kick back, kick off your shoes, and celebrate Denver's funkiest neighborhood.
Normally, when you come across a celebrity in Aspen -- say, Kevin Costner fashioning a kayak for an In Style magazine photo shoot -- it's funny, but not ha-ha funny. For nearly one week out of every year, though, Aspen is the ha-ha-funniest place in the world. The U.S. Comedy Arts Festival is a veritable all-you-can-eat buffet of humor, from standup to sketch comedy to readings; Cheech and Chong, Conan O' Brien, Jim Carrey and Dave Eggers were among those on hand this year. And how about all those hangers-on in fur coats with VIP passes around their necks, talking on headset cell phones? Now, that's funny.
The first of its kind in the United States, The Shoot Out Boulder celebrated the art of quick and cheap movie production. Filmmakers were given 24 hours to complete a seven-minute short. Only in-camera editing was allowed -- meaning everything had to be shot in sequence -- and the footage had to incorporate specific locations or props from within the Boulder area. Several dozen crews of both novice and seasoned filmmakers participated in the quick-paced contest, resulting in an amazing variety of subjects and styles that ranged from the hilarious to the reflective. Plans for another festival are under way, which is great news: The Shoot Out is a can't-miss opportunity for area filmheads.


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Popular property highlights
Located within a leisurely stroll of Oakwood Mall, Baymont Inn and Suites Eau Claire WI is within a few miles (5 km) of Florian Gardens. This 80-room hotel welcomes guests with free breakfast and conveniences like an indoor pool and free in-room WiFi. University of Wisconsin-Eau Claire is also a short drive away.
Start your day off right with a free hot/cold buffet breakfast offered each morning.
The 80 rooms are air-conditioned and have an array of amenities, including microwaves, refrigerators, and coffee makers. 32-inch flat-screen TVs come with cable channels, and guests can stay connected with free WiFi. Bathrooms offer hair dryers and free toiletries. Other standard amenities include free local calls, safes, and ironing boards.
Property features
Guests staying at Baymont Inn and Suites Eau Claire WI enjoy an indoor pool, a fitness center, and free WiFi in public areas. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a meeting room, a 24-hour business center, and coffee/tea in a common area.
- Free hot/cold buffet breakfast
- Free WiFi in rooms and public areas
- Free parking
- Indoor pool
HighlightsInformation missing or incorrect? Tell us!Opens in a new window
Baymont Inn and Suites Eau Claire WI
Hotel Amenities
Hotel Amenities
Baymont Inn and Suites Eau Claire WI features an indoor pool and a fitness center. A computer station is located on site and wireless Internet access is complimentary. Business-related amenities consist of a 24-hour business center and a meeting room. Guests can enjoy a complimentary breakfast each morning. Event facilities measure 524 square feet (49 square meters). This business-friendly hotel also offers coffee/tea in a common area, complimentary newspapers in the lobby, and a fireplace in the lobby. Complimentary self parking is available on site.
Baymont Inn and Suites Eau Claire WI is a smoke-free property.
- 24-hour front desk
- Total number of rooms - 80
- Indoor pool
- Number of floors - 2
- Laundry facilities
- Coffee/tea in common areas
- Free newspapers in lobby
- Free breakfast
- Fireplace in lobby
- Fitness facilities
- Free WiFi
- Computer station
- One meeting room
- Luggage storage
- 24-hour business center
- Conference space size (feet) - 524
- Conference space size (meters) - 49
- Free self parking
- Free RV, bus, truck parking
- Smoke-free property
- Television in common areas
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Laundry facilities
- Refrigerator
- Microwave
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking, Free RV, bus, truck parking
Room Amenities
Baymont Inn and Suites Eau Claire WI offers 80 air-conditioned accommodations with safes and coffee/tea makers. 32-inch flat-screen televisions come with cable channels. Refrigerators and microwaves are provided. Bathrooms include shower/tub combinations, complimentary toiletries, and hair dryers.
This Eau Claire hotel provides complimentary wireless Internet access. Business-friendly amenities include desks and phones; free local calls are provided (restrictions may apply). Additionally, rooms include irons/ironing boards and blackout drapes/curtains. Housekeeping is provided daily.
- Coffee/tea maker
- Phone
- Private bathroom
- In-room climate control (air conditioning)
- Air conditioning
- Free local calls
- Microwave
- Refrigerator
- Daily housekeeping
- Free toiletries
- Hair dryer
- Shower/tub combination
- Iron/ironing board
- In-room safe
- Desk
- Cable TV service
- Flat-panel TV
- Blackout drapes/curtains
- Connecting/adjoining rooms available
- Free cribs/infant beds
- Rollaway/extra beds (surcharge)
- In-room climate control (heating)
- Free WiFi
Where to Eat
Guests are offered a complimentary hot/cold buffet breakfast each morning.
Nearby Things to Do
Recreational amenities at the hotel include an indoor pool and a fitness center.
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- In-room accessibility
- Accessible bathroom
Hotel Policies
Minimum check-in age is 18
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Rollaway/extra beds are available for USD 10.00 per day.
- Free cribs (infant beds)!
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
24-hour check-in
Optional extras
- Rollaway bed fee: USD 10.00 per day
Hotel Name
- Baymont Inn Eau Claire WI
- Baymont Inn WI Hotel Eau Claire
- Baymont Inn Eau Claire WI Hotel
We should mention
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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Q: Did this provider answer all of your questions?
A: Some were answered
Q: Was this provider's staff friendly?
A: Friendly Enough
Q: Did you leave the office feeling satisfied with your visit?
A: Not satisfied, but not unhappy
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A: Fairly Easy
Goodland Dental Arts can be found at Main Ave 504. The following is offered: Doctors & Clinics. The entry is present with us since Sep 8, 2010 and was last updated on Nov 14, 2013. In Goodland there are 5 other Doctors & Clinics. An overview can be found here.
Terry L Imel DDS, Root Canals, Implant Restoration, Dentures, Complete Family Dental Care, Bridge's, Bleaching, Crowns, Carecredit, Including Crowns, Bc/Bs & Delta Dental Providers, Bc/Bs & Delta Dental Provider
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If you're reading this, the chances are you understand what a social enterprise is. But what happens if you work within a social enterprise and your customers don't understand the ethos behind your organisation?
We talked to three community interest companies all facing the challenge of convincing their customers that they are reputable, socially responsible organisations and that profit is necessary to achieve their aims.
There's an increasing amount of scepticism in the media, and therefore in the public domain, of the growing number of organisations leaping on the social enterprise bandwagon. And, yes, there probably are some who are less than scrupulous and may even be exploiting a social cause for their own profit. However, there are also far more social enterprises that really do give a damn and are passionate about their businesses' social agenda. The sticky bit comes in when you consider what happens to the profits and communicating the ethics of this to customers.
Those of us who follow the social enterprise agenda immerse ourselves in articles, tweets and blogs; but the reality is that most people out there have limited interest in, or exposure to, social enterprises – let alone their legal structures. On the whole, if people are interested in social benefit then they appear to be clear on the motivation of charitable and volunteering platforms but are more nervous of "new" structures, perhaps confused by the media portrayal and political perceptions of organisations with social purpose.
Jill Cunningham, director of Essential Social Enterprises works with young people and schools to set up businesses in a socially enterprising way. Within the parameters of the relatively new community interest company legal structure, Cunningham has had to work hard at her marketing.
Before she starts any partnership work, Cunningham thoroughly researches her market and focuses on educating her customers on the social enterprise philosophy, to ensure they understand this is not a voluntary organisation – it's a business. She feels it's important to clarify who will benefit and how she, as a social enterprise, will measure their progress.
However, Cunningham is clear about the tough reality that, irrespective of social objectives, the social enterprise must be profitable and operate successfully. She has found it useful to gain social enterprise qualifications and networks heavily with other similar structures, both locally and through social media.
Matthew Barraud, director of the Morvagh Sailing Project has gone one step further. With a mission to advance the education and personal development of young people through offshore sailing at Plymouth, he's seriously considering starting a charity alongside his CIC, to allay some of his potential customers' suspicions.
Barraud again feels that the public are far more comfortable with the concept of a charity and are wary of the social enterprise model. This is particularly true when trying to negotiate discounts with local funders or suppliers who would prefer him to operate charitably. Parents of the young people participating in the sailing trips are often confused by the CIC concept, as are adult learners taking part in lectures Barraud delivers.
Barraud advises other social enterprises to join supportive local social enterprise forums and networks. He has also enthusiastically launched into the most popular social media networks, which are cheap marketing tools, and necessary for a small business that cannot afford expensive formal marketing and PR.
All this communication activity is crucial. While Barraud considers taking the huge step of initiating a charity to attract business, he is concerned about the many hoops to jump through, the complex governance arrangements and the recruitment and management of a trustee board.
However, Michelle Myers, director of Little Enterprise, is adamant that any social enterprise must not hide from the concept of making profit. She believes it's essential not to be scared to admit you make money. However, she's also clear that, within this structure, any profits will be used differently to normal commercial business. Myers feels customers must be made aware of the limitations for distribution of profits that social enterprise structures have, and that they fall within stringent Companies House regulations.
But for Myers, the community interest company structure suits her business – demonstrating that they are "of the community". She works with young people and schools to set up business in a socially enterprising way, including researching and choosing their own suitable structures. Myers also engages in a significant amount of social media and local networking bodies and connects with many other varied social enterprises. She strongly believes there should be more support for this fast-growing sector.
Finally, Myers advises investigating the newly formed social enterprise "marks' that are launching. The criteria may, for example, ask for accounts to be submitted and investigate the origin of profits; this introduces a rigour that is useful when communicating with external customers and organisations.
Can we help?
Community interest companies are a relatively small, newly sprouting branch of social enterprise. It seems that, in this instance, size really does matter, as these aspiring entrepreneurs struggle to communicate their admirable intentions to their customers and end users. But will there be enough new CICs to shake the newly evolving market up? Or are the limitations simply too stringent for would-be entrepreneurs who want to change the world and yet also be creative with their resultant monetary efforts? What can we, the public, media and government, do to support these change-makers to create and grow successful businesses that benefit our communities?
Sally Higham is the managing director of Higham Consultancy.
This content is brought to you by Guardian Professional. To join the social enterprise network, click here


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WBUR News
Support the news
Patrick Watson On World Cafe
Patrick Watson is back with a new album called Love Songs For Robots. The singer-songwriter has been widely recognized at home in Canada for tremendous albums like Close To Paradise, which won the Polaris Prize in 2009.
Watson was last on World Cafe in 2013 to support Adventures In Your Own Backyard, which moved toward a chamber-pop sound after his earlier, more experimental music. But even though Love Songs For Robots is inspired by science fiction, it continues the ensemble feel of its predecessor. Watson's music has layers of personality, and so does he — he's enormously fun to talk with as he describes what he learned during his early days opening for James Brown, as well as his current work with virtual reality.
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Awesome Federer floors Djokovic in straight sets
By Matt Smith
DUBAI (Reuters) - Roger Federer's enduring class shone through again as the Swiss maestro beat world number one Novak Djokovic 6-3 7-5 to win the Dubai Championships for a seventh time on Saturday.
The 33-year-old's serve is the least praised of his repertoire but it was his awesome delivery that blunted Djokovic's baseline game, taking his career ace haul past the 9,000 barrier with 12 more, several at vital moments.
The match, the 37th in their rivalry which Federer now leads 20-17, proved to be a tale of chances taken and chances missed -- Federer converting his two break points with clinical efficiency, while Djokovic failed on all seven of his.
"We get the best out of each other," Federer said in a courtside interview after winning an 84th tour singles crown.
"I'm pleased I did some good serving when I had to. I definitely won the big points tonight."
Djokovic had two set points to level the match in the second set but both times Federer was rescued by his serve.
"If you don't use these opportunities against Roger, then, you know, he fires back," Djokovic told reporters.
"Small margins, really. Nothing to really worry about. I thought it was a good week overall." Continued...


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Tile City
Tile City is a privately owned retail group and commenced operations in Queensland in 1983. We operate five retail outlets, three in Brisbane as well as branches in Ipswich and on the Gold Coast.
Tile City is a high volume direct importer/buyer of quality product from a large number of overseas and Australian based manufacturers. Our direct importing status means that we are able to offer a vast range of quality product at highly competitive rates.
Through the best service, quality and price we are determined to make Tile City the first and last place you need to look to for all of your tiling needs.Learn more


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ED Magedson – Founder
Ripoff Report
regional acceptance1351 East Bardin Road Internet United States of America
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This report was posted on Ripoff Report on 04/19/2011 09:50 AM and is a permanent record located here: http://www.ripoffreport.com/reports/regional-acceptance/internet/regional-acceptance-scott-cornatzer-no-rights-as-a-consumer-with-regional-worst-custome-719417. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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