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French supermajor Total is facing challenges and opportunities in every part of the Gulf. But given recent discoveries, perhaps the firm's biggest prospect — says Middle East president Arnaud Breuillac — lies in the world of natural gas
If you thought that operating one of the world's top supermajors in the Gulf was simply a licence to print money, then think again. From sabotage in Yemen to politics in Iraq, the challenges that have built up on Arnaud Breuillac's desk in Paris are eclipsed only by the opportunities that exist in this part of the world for those companies that are prepared to think innovatively and adapt to the quick-changing world of global demand.
As president of French giant Total's Middle Eastern operations, Breuillac sits right at the core of what is arguably one of the biggest and most diversified operations ever launched by an international firm into the Gulf. In Abu Dhabi, for example, Total is working hand in hand with local national oil company (NOC) Adnoc on both onshore and offshore operations, as well as owning stakes in local gas, fertiliser and solar interests.
Perhaps Total's primary focus right now is the Abu Dhabi onshore concession, which is up for renewal in January 2014. Testament to that deal's importance was the bumper set of executives the French firm sent to ADIPEC last week, including charismatic chairman and CEO Christophe de Margerie. And while you get the feeling that Breuillac does not have 'favourites', his association with the UAE capital is a long one; some 30 years ago, the Total executive first cut his teeth on overseas projects at the Abu Al Bukhoosh offshore field.
"Energy demand is growing in Abu Dhabi — with the level of activity and the diversification of the economy, so this is where we want to be a partner of choice," Breuillac says. "We will not only bring the technology, which we know we can propose to Abu Dhabi, but we can also develop some of the technology because it doesn't exist today.
"We also need to take a wide view of the needs of Abu Dhabi with regard to its future energy needs," he adds. "There's probably a need to look at carbon sequestration and carbon dioxide emissions. Even if we are not the only firm that can propose this sort of mix of technology and strategic input, we have invested a lot in human resources locally."
Breuillac is firm in his belief that Total can continue to be the best partner for Abu Dhabi, especially given the 75 years the firm has spent operating in the UAE capital. He cites the importance of the onshore concession, describing it as "the treasury of Abu Dhabi", and also extols the virtues of the French firm's academy, which has provided vocational training for young Emiratis, many of whom have gone on to work for Adnoc itself. Furthermore, the executive also points out that Total's long experience in coping with more difficult extraction — he cites the firm's long-held sour gas extraction expertise as an example — will come in handy as Abu Dhabi moves towards developing its more tricky fields. The lucrative nature of the onshore concession deal is such that it has already been subject to intense media speculation.
Other interested parties include BP and ExxonMobil, although the former was excluded from an initial list of bidders released last month following a reported inter-governmental rift between the UAE and the UK. But a quick visit to Abu Dhabi by British prime minister David Cameron in early November appears to have resolved that issue, with Adnoc director general Abdulla Nasser Al Suwaidi telling reporters last week that "everybody has a chance".
"The only thing we know is that the concession will end in January 2014 — for the rest there is a lot of information flying around," Breuillac says. "The reality is that we know Adnoc is working hard on the subject. They are well prepared, the process of consultation is ongoing and I'm sure they will make the right decision on the timeframe, because they have to. This is quite important — the ADCO operation is a key operation for Abu Dhabi's future and it's important for all parties involved to know what's coming next. The countdown is on."
Needless to say, Abu Dhabi is not the sole focus for Total in the region. In Iraq, production from the Halfaya field is coming onstream, while in Oman, Total's contributions to liquefied natural gas (LNG) production are considerable. In the former, Total tied up with China National Petroleum Corporation (CNPC) and Malayia's Petronas to further develop one of Iraq's existing fields. Right now, Breuillac says Halfaya has an average production level of 90,000 barrels a day — well above the capacity that was expected by this time. However, while Total did not participate in the fourth round of licensing (for exploration, as opposed to already-discovered deposits — due to the type of contract that was on offer from the Iraqi government.
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Am quiet angry that Mr Al Abbar talks about high school fees and conveniently forgets about high mall rates, high community fees in his master communities... moreFriday, 19 May 2017 12:22 PM - Vito rammuzzi
I am a vehement non-smoker and suffer terrible headaches when exposed to smoke. If others want to smoke, let them, but restrict smoking to the enclosed... moreSunday, 21 May 2017 6:11 PM - twistedtory
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Other than the high fees..hidden profits being made in the form of huge mark ups on text books, uniforms, shoes even...then there is fees for participation... moreSunday, 14 May 2017 11:17 AM - Joseph
Am quiet angry that Mr Al Abbar talks about high school fees and conveniently forgets about high mall rates, high community fees in his master communities... moreFriday, 19 May 2017 12:22 PM - Vito rammuzzi
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Inclusion and non-discrimination are the values characterizing projects and business tools put in place with a view to improving company performance, rewarding talent in women, and promoting work-life balance for all Intesa Sanpaolo employees. Ours is a conscious approach to the management of diversity within the organization whether it be cultural, ethnic, age or gender and different abilities.
On July 24 2014, this commitment led to the signing of a protocol with the Trade Unions in favour of non-discrimination and equal opportunities policies, with a first agreement which acknowledges special paid leave for both civil and religious weddings, celebrated in Italy or abroad, even if not yet recognized by the Italian law, and provides for the common-law cohabitee the same treatment as a spouse in case of family members with disabilities.
Starting from constant, structured listening to employee needs, the diversity management issue is being carried out both through training initiatives aimed at developing inclusive leadership, that values differences, and through welfare policies with particular attention to the issue of balancing home life and working life of Intesa Sanpaolo employees, such as the regulatory framework provided by the national and Group collective bargaining offering solutions for flexibility, i.e. permits, leave, flexible working hours both morning and afternoon, part-time options, smart working, etc.
Intesa Sanpaolo is a supporting member of Valore D, the association set up by several major companies that have joined together with the aim of helping businesses formulate development strategies for female talents, supporting women on their way towards top management, increasing public discussion on the issue and promoting change.At intercompany level, Intesa Sanpaolo takes part in the different activities activated by the association: Mentorship, to support the growth of female managers through meetings with top managers from other companies; Skill Building, to develop the leadership skills starting from the recognition of gender specificity; Work Life Balance, to promote a model of work more and more innovative; Role Model, to develop management style through the analysis of successful and unsuccessful factors, choices and behaviours; Social Innovation, to promote a model of sustainable leadership that integrates male and female components, by harmonizing the characteristics of both genders.

subset: commoncrawl


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CANADA STOCKS-TSX falls as Europe worries flare up
TORONTO, April 5 (Reuters) - Toronto's main stock index opened lower on Thursday, tracking global markets as European debt crisis worries crimped appetite for riskier assets, though strong Canadian and U.S. jobs data provided some support. The Toronto Stock Exchange's S&P/TSX composite index opened down 6.58 points, or 0.05 percent, to 12,172.08, before modestly extending losses.
© Thomson Reuters 2017 All rights reserved.


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(75 GM soap in packet)
Rs. 82
Rs. 82
(75 GM soap in packet)
Product Details
Glintra Soap is used for acne and oily skin conditions. It heals and treats acne. Glintra is oil free and is enriched with Aloe vera and Milk Cream which moisturizes the skin thus reducing skin dryness.
Glintra Soap is light foaming, non irritating formula, fast-absorbing, penetrates deep and delivers Benzoyl Peroxide in the pores thus effectively killing bacteria that cause acne.
Cleanses and Unclogs the skin pores
Kills acne causing bacteria and helps prevent development of new acne blemishes
Gently removes dirt and excess oil from the skin
Suitable for all skin types
Dosage: As directed by the Dermatologist.
Use under Medical supervision.


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Concrete Creations is wishing you all
Merry Christmas, Happy Chanukkah, happy holidays and a safe and a prosperous new year.
Thank you all for being part of our lives, and helping us reach 22 years in business, we are counting our blessings.
Staying on Top - From Start to Finish.
Big Crates Going Places
We build our own pallets to fit each product, we spend the time and effort to pack and crate them, so they will arrive…Read more
New & Exciting
This is our Odyssey Fire bowl! It is gorgeous, fun and off center. Currently it is offered in 48" x 18" with an Edge…Read more
Where Is The Custom Simplicity?
The Custom Simplicity Fire bowl is designed with an oversized lip to accommodate relaxing around. It acts almost as a table in…Read more
One Stop Shop
We at Concrete Creations used to offer only what we make, however a few years ago, a customer told us that she didn't want to deal with several companies in order to get her fire bowl. Since we listen to our customers, we realized that offering a one stop shop, is good for every one involved. We started offering a complete package; fire bowl, burner, lava, glass, fire stones etc.
Innovative Design
Some of our products come from transforming a sketch off paper into CONCRETE. Original designs are either from Landscape architects or from our studio.
Stay Informed
Over the years of serving our customers, Concrete Creations has developed a sense of what works best. To help our clients' plan for their fire bowl, we have compiled a list of commonly asked questions. We encourage you to ask us to add any additional questions.
News & Events
Christmas 2016Concrete Creations is wishing you…
Thanksgiving 2016This Thanksgiving we are especially…
ONE COUNTRY ONE HEARTTO OUR VETERANS, We appreciate…
Concrete Creations is an unique manufacture of handmade concrete planters, bowls,Avi - AviBet Associates, ASLA


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The Four Most Beautiful Words
I lied. Well technically I didn't, but at the time I was sure I was deliberatly avoiding the truth, so I think I can rightly state I wasn't telling my current truth.
I told you I didn't know much about love. You wanted me to know. Your eyes lit up, as you related to me the wonders of feeling your heart pound, and her gentile lips sending your body quaking into euphoria, this feeling of enveloping calm whenever you see her, and how want to burst in laughter merely at the sound of her voice.
You weren't teaching me about love. You were teaching me about heartache. I became very aware of those silent stabs internally, that you could never know about. I could only nod with a smile, so glad you were so happy, despite the fact my heart was detaching from my body, and shrinking to a size that made breathing a little harder. It was a slight distraction from the searing pain of my emotions.
I thought I knew what love was, when I felt what was missing and knew how badly I wanted it. So I listened to your stories, and your excitement, and your happiness that I could never feel. Because when I listened, I got to hear your voice, and feel your happiness, and make you smile.
Then soon I was listening to arguments, and sobbing, and heartbreak. I was there for you. I understood the heartache inside of you. I soppose I may have made a slip in my logic. For someone who has never loved someone, I sure knew a lot about how to cope with heartache.
And slowly you came out from your sunken state, and you reached up a hand to me to help you up, and as a friend, I will always be there for you.
But you didn't let go of my hand. You held it close, and you whispered my meaning, and you told me of my loyalty, and my bravery, and you saw behind all my veiled pain. You knew your best friend better than your girlfriend, and you felt more joy in my smile than in her laugh. You told me thats when you knew.
A tear ran down my cheek, at I freed the words that had caught in my heart for so long.
"I love you."
And then you muttered the most beautiful words in the world. Those four words. And it was that day that I learned the truth of love. It was love, when it was shared with another person. It escalates to euphoria only between back and forth appriciation. And it soared. I found out what love was, when you freed the other side of my heart with the whispered words, "I love you too."


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Ravyn: Arriving
She weakly pushed the door open and staggered through the door. The hall was empty. She is slim and two half-swords are strapped to her back. She is tall for her folk, but her pointed ears betray her as an elf, one of the Fey Folk. She is beautiful, dark auburn-brown hair, and brilliant emerald eyes that glow with a hidden fire. Although now her eyes are clouded with pain. Her close black clothes cling to her body around her side and on one leg, where there is a tear in the cloth. The wound is visible and its deep. She is breathing harshly, and limping, clutching her side. The cloth there is darker, but her arm covers any wound that might be there. It is clear she has been fighting. She is white from the pain and shaking. She manages to reach the middle of the room before collapsing. She lies still, barely breathing.
I ran to the nearest shelter I could find, aware that if I was caught in the open, I would be killed. Ironically, the Hunter had become hunted. Not many people could get the better of me, but this guy could. Like vampires, elves are stronger, faster and more agile than humans. We have better endurance too. What sets our species apart (other than feeding habits) is that all elves are acutely attuned to their surroundings, and can sense life forms, as well as touch their minds (if they have them) if we wanted to. We can project thoughts or images to another, but elfin etiquette directed the use of that heavily. Some, like me, we free to use these powers as we needed. We were the Hunters for our race, protecting our kind from those who could destroy us. The Fey Folk (our proper title) are a proud but endangered race, living on the edge of legend. Few people have genuinely met a Fey and lived. We have few friends, and live to thousands of years old without our bodies agein beyond 20. We remember the Wars when it was each race for themsleves, and our kind was betrayed, nearly destroyed. It makes it hard to trust.
A Greater Vampire, the strongest kind, had turned against us a while ago, a leftover from the Wars. The elite Hunters of the Elves had been sent against him. Including me. As far as I could tell, I was the only one still running. He had gone after a handfull of us, but I knew that unless I got somewhere for night, he would get me too. He would not rest until we were all dead, because elves had killed his mate in the Wars. I was badly injured, from the fight. I barely made it into the hall when I collapsed, exhausted. I struggled to stay concious, and could vaguely hear voices coming my way. Then things went black.


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Take a stroll in Richland Center along the Pine River Recreation Trail. Even I discovered a few hideaways I didn't know about. Permission to place these caches was given by the RC Parks Dept.
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**Warning! Spoilers may be included in the descriptions or links.
Current Time: 5/25/2017 4:08:40 AM Pacific Daylight Time (11:08 AM GMT)Last Updated: 2017-02-04T04:38:44Z on 2/3/2017 8:38:44 PM (UTC-08:00) Pacific Time (US & Canada) (4:38 AM GMT) Rendered From:UnknownCoordinates are in the WGS84 datum


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PortCityDaily.com is your source for free news and information in the Wilmington area.
Last Wednesday afternoon, Wilmington city council candidates participated in the second public forum in front of a live audience during the weekly public affairs show, CoastLine. The show, which aired on WHQR 91.3 FM in front of a studio audience, will be rebroadcast from 1 to 3 p.m. Saturday, October 10.
The two-hour broadcast featured all eight of the city council candidates running for three open seats. The candidates include:
- Margaret Haynes (incumbent)
- Neil Anderson (incumbent)
- Paul Lawler
- John Presswood
- Frank J. Madonna
- Hollis B. Briggs Jr.
- Alvin Rogers
- Debra Hayes
Starting September 16, Coastline has featured candidates from local races to answer questions from journalists, listeners, and members of a live studio audience. Previous forums included Kure Beach Mayor and Town Council, Oak Island Mayor, and Oak Island Town Council.
The next forums include:
- October 14, Carolina Beach Town Council
- October 21, Carolina Beach Mayor
- October 28, Leland Mayor & Town Council
According to a news release from WHQR, the public is encouraged to participate in the forums by coming to WHQR's MC Erny Gallery beginning at 11:30 a.m on the day of the forum. Doors will close at 11:58 a.m. to meet a firm start time of noon. Listeners can also email questions in advance or during the live event to firstname.lastname@example.com.
After it concludes, the audio will be available on the WHQR website and on their iTunes podcast.
James Mieczkowski is a news reporter for Port City Daily. He can be reached at email@example.com On Twitter: @mieczkowskiPCD
Related Story: City council candidates answer questions about city budget during public forum


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Giuseppe Zampini has been Ansaldo Energia CEO from 2001 until January 2017.
Working from the outset in the power generation sector, he started his career in 1972 at Progettazione Meccaniche Nucleari, before moving on to Nira Spa where he acquired international experience on specific projects.
After these experiences in the field of nuclear power, in 1989 he was appointed to head the Ansaldo Division responsible for energy and steam production plants (cogeneration). Then in 1990/95 he set up and managed Ansaldo Industria of America, acquiring experience in the field of project financing.
He joined Ansaldo Energia in 1997 as General Manager and was appointed CEO in 2001. President of Aspe (Federazione ANIE) Member of ASME.
Abba' has held top management positions first at Foster Wheeler and more recently at WorlyParsons. He was Chairman and CEO at Foster Wheeler Energy Ltd from 2011 to 2015 and CEO at FW Europe, Middle East and Africa from 2013 to 2015.
During his career, he has managed FW operations in the international arena and overseen the completion of major projects in Asia, the Middle East, Africa and Europe.
More recently, he was appointed Group Managing Director at WorlyParsons for Major Projects, Improve, Global Delivery Centres, and Fabrication and Construction operations.


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How do you negotiate a car lease for sale on US's largest classifieds sites (999 results)
dodge (car)
Asking 800 willing to negotiate. Car is considered \'Junked\' because it hasn\'t been smogged in two years therefore ALL PARTS is what it\'s being sold for. Car does RUN and DRIVE just fine btw but not supposed to due to lack of smogging.Interested? Email, call or text me. Year: 2000Model:
Make: Dodge
1966 Chevrolet El Camino
Seller's Vehicle Description 1966 Chevrolet El Camino 283ci V8 engine, 2 barrel carburetor, powerglide transmission, 10 bolt rear end, power drum brakes, power steering, HEI distributor, VIN is 134806KXXXXXX. I bought th
Year: 1966, Make: Chevrolet, Model: El camino
Great running car
Low mileage 104,600.New tires,new fuel system including gas tank.6 cylinder,automatic.Engine runs good,and transmission.Leather interior.Four door.Few cosmetic things could use fixing.Clean but carpeting is wear and tear.Willing to negotiate.Has to go selling it for my daughters college.Selling it as
104,600 Miles
Cute reliable car perfect for student
This car has been there through thick and thin with me I hate to get rid of her but my family is about to get one more little bundle of joy bigger :) the car is a 2002 Hyundai Elantra, 4 door, manual, I had a new, used motor put in her in august along with the clutch and she runs like a champ! The mot
2005 Monte Carlo (Great Car)
2004 Lexus Es330 clean car 170,000 miles
The car is all clean. It is like new. I just replaced the struts ant brake pads & rotors for this car. I also replaced new tires. The car runs very smooth and great. I love it but i am moving to another so i thought to sell this car. It has clean title. Regular oil change and every thing was done.
179,000 Miles
Year: 2004, Make: Lexus
Someone to let me use their car
2003 Audi Allroad 2.7T Quattro - Willing to Negotiate!
Up for sale is my 2003 Audi Allroad Quattro wagon. This car has been my daily driver for a little while, but I have too many cars and this one lost the coin flip. It is cobalt blue in color, even though it almost looks black. The car has 135,500 miles on it, and runs very well. It has had it's timing
135,500 Miles
Year: 2003, Make: Audi, Model: Allroad
Need a cheap car to get around town? I got you.
Need to get around town and need a car quickly? Have a high schooler you're sick of driving around? Just need something during the winter months when biking to work is getting harder and harder? I've got the car for you.Introducing the 1997 Ford Taurus! Complete with an engine, working heater
118,065 Miles
2007 Lincoln MKZ for sale142K MilesNo DentsNo ScratchesNo RustLeather Seats (heated and cooled option)SunroofAutomaticOverall, it is a great car! I am leasing a new car so this is the only reason I am selling the car.There are no issues with the car, and two new
142,000 Miles
Year: 2007, Make: Lincoln, Model: Mkz
1979 Z28 camaro pro street/drag car
79 Z28 drag car.Engine: BBC, Pro Systems carb, Edelbrock Victor CNC ported heads, Edelbrock super victor intake, comp cams mechanical roller cam, Crane rockers & stud girdles, Canton 8qt pan, Lemons headers. Have dyno sheet for engine.Front suspension: TRZ motorsports chromoly upper &a
Year: 1979
Willing to negotiate
I have a 2000 Passat VW Turbo. I love this car, had great time in this car. Wish I had the time & tools to fix. It's totally worth the fix. Can also make a great parts car. Everything works. Runs & sounds great. This car will last you. Never had an issue. Just recently blew the head gasket. H
***Genesis Coupe***WILL NEGOTIATE***
Cheap low mileage car need gone asap
1998 Chevrolet Malibu-- good condition willing to negotiate OBO
I got this car for free, so I am selling it just to make extra cash. Runs real good, interior needs cleaned up but nothing that would affect value. 1998 chevy Malibu 102k miles( actual). Dead inspection as of 12/2016. Not tagged, clean title. I am the owner. Shoot a reasonable offer, or have cash in h
102,000 Miles
Year: 1998, Make: Chevrolet, Model: Malibu
Clean 2006 crown vic less then 70,000 miles
1979 Z28 camaro pro street/drag car
79 Z28 drag car.Engine: BBC, Pro Systems carb, Edelbrock Victor CNC ported heads, Edelbrock super victor intake, comp cams mechanical roller cam, Crane rockers & stud girdles, Canton 8qt pan, Lemons headers. Have dyno sheet for engine.Front suspension: TRZ motorsports chromoly upper &a
1 Miles
Year: 1979
Ford Fusion SE 2012
Car is in amazing condition. Just stuck new breaks on the car. Car is like brand new. Car has cloth seats, power windows, cruise control and other extras. Serious inquiries only. I am wanting $9,200 OBO for the car and willing to negotiate. Car only has 69K miles. Contact me through text on my cell
65,000 Miles
Year: 2012, Make: Fusion, Model: Fusion
Car for sale
2013 Chevy Cruze - Car
2013 Chevrolet Cruze car for sale. LT 4 door sedan with 56,000 miles. Has been kept in very good condition. Has always been serviced by the original dealership that we bought it from. This is a one-owner car. Non-smokers with no children. Very clean interior and exterior. We are looking to sell
55,755 Miles
Year: 2013


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Joseph Frisicano271 grantham e Deerfield Beach, Florida United States of America
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text:
Magic from the heart :) Part 2
Essay by: MagicmanFarhanul
Status: Finished
Genre: Romance
There were times when I wanted to move on with someone else but whats the use of a relationship if u don't love that person.As someone once told me, "don't hurt a girls feeling just to make someone else happy". Thus, I dint want to hurt anyone else as I knew by now, how it feels to get hurt.
There were even times when my joyful mood use to turn into sudden depression.Trust me,those werent a great feeling but happy that I had great friends who I could share things easily with and they used to be my support all the time.
There were even times when I was suppose to visit the country she was living in and for some weird reasons the trip used to get canceled.As a result,it badly used to break me apart from inside but just couldn't show it.
There was one good thing that I learned from all this was "tolerance".It made me so strong that I stopped missing people and it was like my heart lost all its taste.As they say,everything has its good side and I could find the positive side out of it and it did help me a lot in many ways.
There was one funny incident that still makes me laugh through out all this years.I once took my admission in one of the schools in the country she was living in but the funny thing was ,I couldn't find a reason to tell my dad for going there as I had better schools in nearby countries and the school I was studing in was one of the best in my country too.
It still amazes me thinking,how the years past so fast.It feels as if it was yesterday and how things rapidly change with time.In addition,how some simple things can make a huge mark in our lives and we get to learn new things along with it.I guess that's the meaning of the word "life".
Till now everything is just going good and I am being optimistic about every single thing that is coming on my path.Wishing that things will become better as the time passes.As they say,patience is the solution to a lot of problems.I even know my friend really well.I have that much faith in her that she will fix everything as they were in the past and this story will have a happy ending like any other fairy tale story.
© Copyright 2017 MagicmanFarhanul. All rights reserved.
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Short Story / Romance


text:
Rediscover your skin's youthful capacity with Eucerin® Sensitive Skin Q10 Active Anti-Wrinkle Day Cream, a dermatologically-tested, anti-ageing formula that works to counteract the signs of premature ageing whilst intensely moisturising dry, sensitive skin.
Premature ageing occurs when levels of Coenzyme Q10 (a naturally occurring antioxidant) deplete over time; compromising the skin's resistance and increasing its susceptibility to UV-induced free radicals. To combat this, the nourishing day cream is enriched with Coenzyme Q10 to effectively boost and support cell regeneration for visibly reduced fine lines and wrinkles, and younger looking skin.
Suitable for sensitive skin, the quick absorbing cream will re-energise cells and protect your skin from free radical attacks, leaving your complexion hydrated, re-texturised and visibly younger looking. - K.N.
Free from parabens, fragrances and artificial colourants.
The light yellow colour is due to the natural colour of the ingredients, Q10 Active does not contain any colourants.


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10911 Hannes Court
Silver Spring, Maryland, 20901
Commute to Downtown Silver Spring
Almost all errands require a car.
A few nearby public transportation options.
About your score
10911 Hannes Court has a Walk Score of 16 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
This location is in Silver Spring. Nearby parks include Breewood Park, North Four Corners Local Park and Sligo-Dennis Avenue Local Park.
Explore how far you can travel by car, bus, bike and foot from 10911 Hannes Court.
10911 Hannes Court has some transit which means a few nearby public transportation options. Car sharing is available from RelayRides.
Bus lines:
0.1 mi
0.1 mi
9 Silver Spring-Wheaton
0.2 mi
8 Silver Spring-Wheaton
0.2 mi
Car shares:
View all Silver Spring apartments on a map.
Popular apartment searches include hardwood floor, fitness and pool.
Search for homes in Silver Spring or find a Silver Spring real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
This location is in the city of Silver Spring, MD. Silver Spring has an average Walk Score of 59 and has 71,452 residents.Learn More About Silver Spring


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Mumbai, Sep 1 (ANI): Finance Minister Pranab Mukherjee on Wednesday asked the insurance companies to create awareness among the poor and vulnerable section of the society especially the people living in rural areas so that they can avail the benefits of financial services.
Addressing a large gathering of the representatives of the insurance companies in a function organized by Assocham on the occasion of Global Insurance Summit here today, Mukherjee said that the poor people must be informed about the benefits of the life insurance and insurance against natural calamities.
"One of the important challenges before the insurance industry today is to generate the required level of awareness about the benefits of insurance to our people particularly living in semi-urban and rural areas. It should be our endeavour to take all necessary steps to ensure the reach of insurance to masses," said Mukherjee.
"As for meeting their rural and social obligation, the insurance companies are now increasingly tapping the semi-urban and rural areas to spread the message of protection of life and property through insurance cover," he added.
The Finance Minister said the Central Government has also introduced many special products aimed at the rural markets like Jan Shree Bima Yojana, Universal Health Insurance Scheme, Aam Admi Bima Yojana, Crop Insurance, etc. for the benefit of poor and needy populace in the country.
Mukherjee further said one of the main objectives of promoting financial inclusion packages is to economically empower those sections of society which are otherwise denied access to financial services, by providing banking and credit services thereby focusing on bridging the rural credit gap.
"Lack of protective elements may not serve the objective of promoting financial inclusion packages as the targeted section may fall back into the clutches of poverty in the event of unforeseen contingencies. Hence, to provide a hedge against these unforeseen risks, popularization of micro insurance is one of the essential ingredients of financial inclusion package," said Mukherjee.
Mukherjee asked Life Insurance Corporation to increase its contribution to two percent of GDP from its present contribution of 1.84 percent of GDP.
He also asked the insurance companies to follow the system of benchmarking, introduce new insurance products, reduce the premium of policies and increase the visibility of the different insurance policies and products through print and electronic media, seminars and discussions etc.
Mukherjee further said the Government has implemented the Rashtriya Swasthya Bima Yojana for the benefit of poor people in the country. Many states have adopted this scheme.
"However, the health insurance still covers a very miniscule population of this country. The insurers have to ensure further penetration of the health insurance in this country. Simultaneously, there is a need to concentrate that the premiums are affordable for the insured," he added.
Assocham President Swati Piramal, IRDA Chairman T.S. Vijayan, LIC Chairman and Chairman of V.N. Dhoot and Videocon were also present on this occasion among others. (ANI)


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Neighbors say man running hostel out of Conway area house
ORANGE COUNTY, Fla. - Central Florida has hundreds of hotels for tourists, but Channel 9 has learned that there's one hot spot for travelers that's been operating for a year, under the radar, in a residential neighborhood.
The makeshift hostel is located on Simmons Road, right in the heart of the Conway area.
Channel 9's Karla Ray found out the business is about to be shut down by Orange County Code Enforcement.
Code enforcement was just at the house Wednesday.
The man running the house told Ray there are still guests inside right now.
He said that after a year of being in business he had no idea he was doing anything wrong.
A neighbor, who didn't wish to be identified, called code enforcement after finding out the home is rented out nightly to tourists.
"We found out it was an international hostel for young people," said the neighbor.
Manny Dume is renting the house, and renting out the rooms.
"Did it occur to you to go to code enforcement ahead of time and ask them if it's OK to run a hotel out of a home?" Ray asked Dume.
"It's not a hotel," said Dume.
Dume told said he charges $25 a night.
The house is described as a 'hostel-style sleeping arrangement' on the website hostels.com.
"Why is this listed on hostels.com?" Ray asked Dume.
"It's listed as a world united international house," said Dume.
The house is zoned as a single-family residence; it's not authorized for any business use.
Dume said he plans to cooperate with code enforcement, which means he'll have to shut down.
If the business is not shut down the county could fine him up to $1,000 per day.


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Sambousik Jibne
42,466pages onAdd New Page
this wiki
this wiki
Description Edit
Lebanese cheese pastries
Ingredients Edit
- 5 cups all purpose plain flour
- 1½ cups lukewarm water
- 2 tbsp salt
- 2 tbsp sugar
- vegetable oil for deep frying
- 1 cup oil
Cheese filling Edit
- 14 oz white cheese (Ikawi Altishiki)
- ¼ cup finely chopped fresh parsley
- ¼ tsp ground cayenne pepper
Directions Edit
- Prepare Lebanese Basic Dough.
- Cover and leave aside for 1 hour.
- Divide dough into walnut-size balls. Roll out to form circles (8 cm diameter).
- Put filling on one side of each circle.
- Fold over one end to make semi-circles.
- Press edges with fingers.
- Fry in 1 cup of vegetable oil over medium heat. Brown both sides.
- Serve hot.
Cheese filling Edit
- Mix ingredients and put aside.


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High density multi-family development land in the heart of Fitchburg, WI! Adjacent parcel at 2641 S Fish Hatchery also available. 2.03 total acres available!
Features Lots and Acreage
|Total Acres: 2.0
|Zoning: G1
|Present Zoning: Single family
|Lot Size:
|Lot Description:
|Taxes: $4,604
|Elementary School: Leopold
|Middle School: Cherokee
|High School: West
|School District: Madison Metropolitan
|Body of Water:
Estimate your monthly mortgage payment
How much can I borrow?
Speak with a mortgage consultant: 866-531-0904


text:
TTLIFE XL 13.5" Long Silicone Heat Resistant BBQ Grill Oven Gloves Baking
Regular price
|3" longer than typical barbecue gloves to protect your forearms. Includes 1-Pair Built To Last, BPA-Free, FDA Approved, Pure Silicone Oven Gloves For Cooking, Grilling, Potholders, Camping, Pickling, and So Much More! HEAT RESISTANT DURABILITY For Temperatures Up To 425 Degrees Fahrenheit - Protect Your Hands Against Heat While Cooking or BBQing, Avoid Accidents SUITABLE FOR EVERYONE - No-Slip Five Finger Design To Allow Safe Movement Of Hot Items and Boiling Water With a Strong Grip. Handle Scrumptious Meats Like Chicken and Pulled Pork With Ease.
On Jun-30-16 at 01:22:27 PDT, seller added the following information:


text:
Kalkaji, Delhi, India- 110019.
Is this listing inaccurate or duplicate? Any other problem?
Please tell us about the problem and we will fix it.
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Coaching provided for:
CA Final
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Class Location:
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Class Location:
My Institute
Training for CCNA certification in:
CCNA Cloud
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CCNA SP operations
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Type of Computer course taken :
Training in Computer tools usage
Training in Software application usage
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Basics of Computer usage
Class Location:
My Institute
TA 98, Okhla Main Road,
Kalkaji, Delhi
Kalkaji, Delhi, India- 110019. .


text:
Stylish Apartment Barbican London - Glasshouse 1
Maximální počet hostů4
Počet místností1
Velikost40 m²
Floor No.2
- Kuchyně
- Pračka / sušička
- Televize
- Vhodné pro rodiny s dětmi
- Internet/WiFi
- Dětská postel
Accommodation summary
|Glasshouse Yard, EC1A 4JN London, Velká Británie
|Typ nemovitosti
|Ident. objektu
|Acceptance rate
|< 50%
|Response time
|A few hours
|Calendar updated
|2 weeks ago
Short introduction
3 people maximum 40 sqm.
2nd floor without lift.
1 bedroom, 1 air mattress available on request, 1 shower room,
You can arrive at King's Cross train station via the tube, or stay on the line for the hip Camden Town with its markets and pubs. The other direction takes you to London Bridge.
"In 2012, the Javelin train will use its 340 seat capacity on the Olympic Javelin Train service that promises to speed spectators from St Pancras to the main Olympic Games site in Stratford - East London in 7 minutes. With this promise of speedy, effective travel to the London Olympics site it's rather apt that the trains have been named after British personalities who we'll associate with speed".
Nearby Undergound: Old Street (Northern Line), National Rail and kings cross international
Dining area
The dining suite has a stylish black and purple table with seating for 2 although an additional chair can be provided for an extra guest.
This loft style Apartment boasts a double bed with night lamps as well as a dressing or make up table, the windows are large and bring in the daylight. Design features include a striking spin painting by Damien Hirst on the walk up to the apartment.There is also a large wall mounted flat screen TV, with Freeview and DVD player with DVDs.
The fully tiled red and black bathroom has an Power shower, WC, Wash hand basin, and large heated tower rail. The bathroom had been styled with a ships porthole as a window which only adds to its unique style.
Apart from providing a complete set of kitchenware, the kitchen is also fully equipped with: electric hob, microwave oven, refrigerator, kettle, toaster and all the crockery and cooking utensils you will need for your stay. There is also a washing machine in this apartment as well as heating and hot water controles.
Between 15-00hrs-17-00hrs
Between 09-00hrs-11-00hrs
There is a surcharge of £50.00 to check-in/check-out on Bank holidays and Christmas.
Domovní řádWe are a family friendly block of 4 apartments. Be respectful to the neighbors and other tenants especially when it comes to noise levels after 11 pm
No Parties
No Smoking
No Pets
No extra number of guests
If you find anything wrong with the apartment please report it immediately, via email or telephone.
Any breach of conditions can mean you loose your deposit
Check out is at 11am
Check in is at 3pm
|Weekly rate for up to 3 guests
|750 €
|Monthly rate for up to 3 guests
|3151 €
|Cena za více než 3 ubytované(ých)
|24 € Cena za osobu/noc navíc
|Maximální délka pobytu
|1 měsíc
|Příjezd po
|Check-in before
|Odjezd před
|Stornovací podmínky
The apartament is in the centre of London, in the yelow line of the tube. It is small, but enough to visit London a week. In London Public transport is too much expensive, and you can go to the mayority of the places on foot.
The email contact with the host was very friendly and the pictures looked very good so we were looking forward to it very much. Unfortunally the appartment was a bit of a disappointment. We had specifically asked if the flat was suitable for four persons. The double bed was ok, but the sofa bench was much too small and very hard. As a result, at least two of us had bad nights and woke up every morning with pain in the back. The flat was not "stylish" but rather outdated and it was not as clean as we expected. On the other hand, it was very close to Barbican metro station and the supermarket and restaurants in the neighbourhood were very convenient. We loved London but won't go back to this place.
Good location, close to underground station. Not good equipped for 4 persons (small table, old air mattress).
Apartment with good price/value relation just about 200m away from Barbican subway station in the Northern part of "The City" (Glasshouse Yard).
Clean with all necessary equipment - though not modern - and convenient for our 6 day stay in London.
If you have problems getting anything to operate (TV,..), just contact the helpful and friendly staff. Remember to bring an adapter for your own electrical devices.
Should not be confused with a (much more expensive) 5 star hotel, however.
A gold choice visit London. Near to tube, train. In a 10 minutos walk you get Saint Paul's. Cozy an Well equiped apartment
I arranged my booking with Marsha from Green Tree. Not only was she extremely helpful and always responded to every email really quickly, she also found ways to make it as easy on us as possible in terms of checking in early and assisting with tips and information.
The Red Room apartment was bright and clean! The location is perfect, since you can access the exciting spots of London by foot easily. I would definitely return here or to any other Green Tree apartment! Excellent value for money!
The apartment was great! Very clean, nice and warm during winter, top location in the center of London. The check-in and check-out worked very smoothly, also during late hours. You're gonna receive very detailed instructions to access the place. I can definitely recommend it!
Great, clean apartment at a great location, really close to the tube and therefore perfect for exploring London. I would definitively consider it again for my next stay. Nice hosts that are very responsive. Not a good choice for people that can't climb stairs for there is no elevator in the building. Be aware that a cash deposite is required - I wasn't aware of that. Only four instead of five stars because initial communication could have been better - I'm sure this has been an exceptional problem and next time I stay here I'll be able to rate 5 stars.
- Ověřenou kvalitu ubytování
- Prověření každého hostitele
- Bezpečné platby prostřednictvím SSL šifrování


text:
While the rest of the Nats were busy tying the Marlins on the second day of Spring Training games, a quintet of D.C. baseball stars took in Jimmie Johnson's victory in the Daytona 500.
Jayson Werth, Ryan Zimmerman, Adam LaRoche, Tyler Clippard and Craig Stammen all were expected to attend Daytona International Speedway on Sunday afternoon. Stammen tweeted from the event, while various on-site observers captured images of Werth, Zimmerman and LaRoche.
The first baseman managed to photobomb one of Johnson's post-race interviews, while Zimmerman did an interview with SiriusXM Radio's NASCAR channel. Werth, meanwhile, has a large beard. Mike McCarthy, who took the first photo above, said that Werth was standing next to the guys from Duck Dynasty, and bystanders thought he was one of the guys on the show.
(Images via @mikemcc1717, @dfloodhive and the SiriusXM NASCAR Facebook page.)


text:
ED Magedson – Founder
Ripoff Report
nationa credit services.,llcInternet USA
nationa credit services.,llc Richards andrews scammers Internet
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I recieve an e-mail from richards andrews.,telling me i have a case and it will be dowloaded to the courthouse if i dont response within 24 hrs., he said if i want to settle it outside the courthouse to avoid all penalties and be in a total mess.that i should contact him by e-mail to let him know hold the case and settle it..I really want this kind of people to be punish because im a good citizen of this country and i dont deserve to be threatened like this and have my identity ruin.I have a medical conditon and this kind of things is not good for my health.. I hope that you can help all the victims of this crime..thank you and more power to you.
This report was posted on Ripoff Report on 05/02/2014 03:36 PM and is a permanent record located here: http://www.ripoffreport.com/reports/nationa-credit-servicesllc/internet/nationa-credit-servicesllc-richards-andrews-scammers-internet-1143655. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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text:
A Tale of Mumbai City
The capital with the Indian condition, Mumbai; previously generally known as the town of Bombay, is made up of 7 highlands. Considered as being the middle in the Indian point out in terms of the commercial plus the amusement field, it contributes up to 5 % of your overall gross domestic product or service Bra Mat Hemma matkasse.
The inexpensive and social progress inside the town is fantastic and commendable. While the folks who live in just the city originate from diverse economic, social, ethnic teams and spiritual groups, they've always uncovered a way of co-existing together by mixing every one of these elements to kind a single front.
Mainly because of the economic track record within just the city, people from India and various states are flooding town with the hope of tapping in the industry. As a result, the city is constituted by Maharashtra, Gujarati, Parsi and Islamic groups. Amid many of the companies that were shaped to glimpse in to the growth issues of the city, involve the CIDCO Company.
This was performed in 1971 and its main objective was to reduce the inhabitants rate while in the metropolis by developing a new metropolis not much from Mumbai and adorn it with economically seem ventures, which might decrease the inhabitants advancement. By 1991, each time a census was completed, it was proven which the inhabitants had lessened by ten %. Nevertheless this is actually the scenario, from the next subsequent a long time, the population fee went on the rise yet again.
The town also has over twelve thousand chook species which make the chook seeing segment with the tourism sector extremely enterprising. The majority of these species are rare birds that cannot be uncovered some other location during the globe. No matter what else may very well be claimed about Mumbai, the one particular point that may be specific will be the great mother nature of your persons who inhabit town. They may be a hardworking folks who are obviously outlined by their tradition, artwork, music, and non secular views.


text:
Pulmonary surfactant proteins and lipids are required for lung function after birth. Lung immaturity and resultant surfactant deficiency cause respiratory distress syndrome, a common disorder contributing to morbidity and mortality in preterm infants. Surfactant synthesis increases prior to birth in association with formation of the alveoli that mediate efficient gas exchange. To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse. Deletion of Cnb1 caused respiratory failure after birth and inhibited the structural maturation of the peripheral lung. Synthesis of surfactant and a lamellar body–associated protein, ABC transporter A3 (ABCA3), was decreased prior to birth. Nuclear factor of activated T cells (Nfat) calcineurin-dependent 3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, Abca3, Foxa1, and Foxa2 genes. The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
Vrushank Davé, Tawanna Childs, Yan Xu, Machiko Ikegami, Valérie Besnard, Yutaka Maeda, Susan E. Wert, Joel R. Neilson, Gerald R. Crabtree, Jeffrey A. Whitsett
Kaushik Parthasarathi, Hideo Ichimura, Eiji Monma, Jens Lindert, Sadiqa Quadri, Andrew Issekutz, Jahar Bhattacharya
Acute lung injury (ALI), which is associated with a mortality of 30–40%, is attributable to inflammation that develops rapidly across the lung's vast vascular surface, involving an entire lung or even both lungs. No specific mechanism explains this extensive inflammatory spread, probably because of the lack of approaches for detecting signal conduction in lung capillaries. Here, we addressed this question by applying the photolytic uncaging approach to induce focal increases in Ca2+ levels in targeted endothelial cells of alveolar capillaries. Uncaging caused Ca2+ levels to increase not only in the targeted cell, but also in vascular locations up to 150 μm from the target site, indicating that Ca2+ was conducted from the capillary to adjacent vessels. No such conduction was evident in mouse lungs lacking endothelial connexin 43 (Cx43), or in rat lungs in which we pretreated vessels with peptide inhibitors of Cx43. These findings provide the first direct evidence to our knowledge that interendothelial Ca2+ conduction occurs in the lung capillary bed and that Cx43-containing gap junctions mediate the conduction. A proinflammatory effect was evident in that induction of increases in Ca2+ levels in the capillary activated expression of the leukocyte adherence receptor P-selectin in venules. Further, peptide inhibitors of Cx43 completely blocked thrombin-induced microvascular permeability increases. Together, our findings reveal a novel role for Cx43-mediated gap junctions, namely as conduits for the spread of proinflammatory signals in the lung capillary bed. Gap junctional mechanisms require further consideration in the understanding of ALI.
Kaushik Parthasarathi, Hideo Ichimura, Eiji Monma, Jens Lindert, Sadiqa Quadri, Andrew Issekutz, Jahar Bhattacharya
Adenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In vitro studies suggest that activation of the A2B adenosine receptor (A2BAR) results in proinflammatory and profibrotic effects relevant to the progression of lung diseases; however, in vivo data supporting these observations are lacking. Adenosine deaminase–deficient (ADA-deficient) mice develop pulmonary inflammation and injury that are dependent on increased lung adenosine levels. To investigate the role of the A2BAR in vivo, ADA-deficient mice were treated with the selective A2BAR antagonist CVT-6883, and pulmonary inflammation, fibrosis, and airspace integrity were assessed. Untreated and vehicle-treated ADA-deficient mice developed pulmonary inflammation, fibrosis, and enlargement of alveolar airspaces; conversely, CVT-6883–treated ADA-deficient mice showed less pulmonary inflammation, fibrosis, and alveolar airspace enlargement. A2BAR antagonism significantly reduced elevations in proinflammatory cytokines and chemokines as well as mediators of fibrosis and airway destruction. In addition, treatment with CVT-6883 attenuated pulmonary inflammation and fibrosis in wild-type mice subjected to bleomycin-induced lung injury. These findings suggest that A2BAR signaling influences pathways critical for pulmonary inflammation and injury in vivo. Thus in chronic lung diseases associated with increased adenosine, antagonism of A2BAR-mediated responses may prove to be a beneficial therapy.
Chun-Xiao Sun, Hongyan Zhong, Amir Mohsenin, Eva Morschl, Janci L. Chunn, Jose G. Molina, Luiz Belardinelli, Dewan Zeng, Michael R. Blackburn
Bronchial asthma, the most prevalent cause of significant respiratory morbidity in the developed world, typically is a chronic disorder associated with long-term changes in the airways. We developed a mouse model of chronic asthma that results in markedly increased numbers of airway mast cells, enhanced airway responses to methacholine or antigen, chronic inflammation including infiltration with eosinophils and lymphocytes, airway epithelial goblet cell hyperplasia, enhanced expression of the mucin genes Muc5ac and Muc5b, and increased levels of lung collagen. Using mast cell–deficient (KitW-sh/W-sh and/or KitW/W-v) mice engrafted with FcRγ+/+ or FcRγ–/– mast cells, we found that mast cells were required for the full development of each of these features of the model. However, some features also were expressed, although usually at less than wild-type levels, in mice whose mast cells lacked FcRγ and therefore could not be activated by either antigen- and IgE-dependent aggregation of FcεRI or the binding of antigen-IgG1 immune complexes to FcγRIII. These findings demonstrate that mast cells can contribute to the development of multiple features of chronic asthma in mice and identify both FcRγ-dependent and FcRγ-independent pathways of mast cell activation as important for the expression of key features of this asthma model.
Mang Yu, Mindy Tsai, See-Ying Tam, Carol Jones, James Zehnder, Stephen J. Galli
Activation of latent TGF-β by the αvβ6 integrin is a critical step in the development of acute lung injury. However, the mechanism by which αvβ6-mediated TGF-β activation is regulated has not been identified. We show that thrombin, and other agonists of protease-activated receptor 1 (PAR1), activate TGF-β in an αvβ6 integrin–specific manner. This effect is PAR1 specific and is mediated by RhoA and Rho kinase. Intratracheal instillation of the PAR1-specific peptide TFLLRN increases lung edema during high-tidal-volume ventilation, and this effect is completely inhibited by a blocking antibody against the αvβ6 integrin. Instillation of TFLLRN during high-tidal-volume ventilation is associated with increased pulmonary TGF-β activation; however, this is not observed in Itgb6–/– mice. Furthermore, Itgb6–/– mice are also protected from ventilator-induced lung edema. We also demonstrate that pulmonary edema and TGF-β activity are similarly reduced in Par1–/– mice following bleomycin-induced lung injury. These results suggest that PAR1-mediated enhancement of αvβ6-dependent TGF-β activation could be one mechanism by which activation of the coagulation cascade contributes to the development of acute lung injury, and they identify PAR1 and the αvβ6 integrin as potential therapeutic targets in this condition.
R. Gisli Jenkins, Xiao Su, George Su, Christopher J. Scotton, Eric Camerer, Geoffrey J. Laurent, George E. Davis, Rachel C. Chambers, Michael A. Matthay, Dean Sheppard
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related mortality. To explore the pathogenesis of TRALI, we developed an in vivo mouse model based on the passive transfusion of an MHC class I (MHC I) mAb (H2Kd) to mice with the cognate antigen. Transfusion of the MHC I mAb to BALB/c mice produced acute lung injury with increased excess lung water, increased lung vascular and lung epithelial permeability to protein, and decreased alveolar fluid clearance. There was 50% mortality at a 2-hour time point after Ab administration. Pulmonary histology and immunohistochemistry revealed prominent neutrophil sequestration in the lung microvasculature that occurred concomitantly with acute peripheral blood neutropenia, all within 2 hours of administration of the mAb. Depletion of neutrophils by injection of anti-granulocyte mAb Gr-1 protected mice from lung injury following MHC I mAb challenge. FcRγ–/– mice were resistant to MHC I mAb–induced lung injury, while adoptive transfer of wild-type neutrophils into the FcRγ–/– animals restored lung injury following MHC I mAb challenge. In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fcγ receptors.
Mark R. Looney, Xiao Su, Jessica A. Van Ziffle, Clifford A. Lowell, Michael A. Matthay
To define the factors that control the tissue effects of IL-4, we compared the effects of Tg IL-4 in Balb/c and C57BL/6 mice. In the former, IL-4 caused modest eosinophilic inflammation and mild airway fibrosis and did not shorten survival. In C57BL/6 mice, IL-4 caused profound eosinophilic inflammation, airway fibrosis, emphysematous alveolar destruction, and premature death. These differences could not be accounted for by changes in Th2 or Th1 cytokines, receptor components, STAT6 activation, MMPs, or cathepsins. In contrast, in C57BL/6 mice, alveolar remodeling was associated with decreased levels of tissue inhibitors of metalloproteinase 2, -3, and -4 and α1-antitrypsin, and fibrosis was associated with increased levels of total and bioactive TGF-β1. Impressive differences in adenosine metabolism were also appreciated, with increased tissue adenosine levels and A1, A2B, and A3 adenosine receptor expression and decreased adenosine deaminase (ADA) activity in C57BL/6 animals. Treatment with ADA also reduced the inflammation, fibrosis, and emphysematous destruction and improved the survival of C57BL/6 Tg animals. These studies demonstrate that genetic influences control IL-4 effector pathways in the murine lung. They also demonstrate that IL-4 has different effects on adenosine metabolism in Balb/c and C57BL/6 mice and that these differences contribute to the different responses that IL-4 induces in these inbred animals.
Bing Ma, Michael R. Blackburn, Chun Geun Lee, Robert J. Homer, Wei Liu, Richard A. Flavell, Lynn Boyden, Richard P. Lifton, Chun-Xiao Sun, Hays W. Young, Jack A. Elias
Complement component 5 (C5) has been described as either promoting or protecting against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting pleomorphic effects of C5. Here we report that local pharmacological targeting of the C5a receptor (C5aR) prior to initial allergen sensitization in murine models of inhalation tolerance or allergic asthma resulted in either induction or marked enhancement of Th2-polarized immune responses, airway inflammation, and AHR. Importantly, C5aR-deficient mice exhibited a similar, increased allergic phenotype. Pulmonary allergen exposure in C5aR-targeted mice resulted in increased sensitization and accumulation of CD4+CD69+ T cells associated with a marked increase in pulmonary myeloid, but not plasmacytoid, DC numbers. Pulmonary DCs from C5aR-targeted mice produced large amounts of CC chemokine ligand 17 (CCL17) and CCL22 ex vivo, suggesting a negative impact of C5aR signaling on pulmonary homing of Th2 cells. In contrast, C5aR targeting in sensitized mice led to suppressed airway inflammation and AHR but was still associated with enhanced production of Th2 effector cytokines. These data suggest a dual role for C5a in allergic asthma, i.e., protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment.
Jörg Köhl, Ralf Baelder, Ian P. Lewkowich, Manoj K. Pandey, Heiko Hawlisch, Lihua Wang, Jennifer Best, Nancy S. Herman, Alyssa A. Sproles, Jörg Zwirner, Jeffrey A. Whitsett, Craig Gerard, Georgia Sfyroera, John D. Lambris, Marsha Wills-Karp
In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of polymorphonuclear leukocytes (PMNs) into the lung. Since CXCR2 ligands, including CXCL1 and CXCL2/3, are chemotactic for PMNs, CXCR2 is thought to recruit PMNs by inducing chemotactic migration. In a model of PMN recruitment to the lung, aerosolized bacterial LPS inhalation induced PMN recruitment to the lung in wild-type mice, but not in littermate CXCR2–/– mice. Surprisingly, lethally irradiated wild-type mice reconstituted with CXCR2–/– BM still showed about 50% PMN recruitment into bronchoalveolar lavage fluid and into lung interstitium, but CXCR2–/– mice reconstituted with CXCR2–/– BM showed no PMN recruitment. Conversely, CXCR2–/– mice reconstituted with wild-type BM showed a surprisingly large defect in PMN recruitment, inconsistent with a role of CXCR2 on PMNs alone. Cell culture, immunohistochemistry, flow cytometry, and real-time RT-PCR were used to show expression of CXCR2 on pulmonary endothelial and bronchial epithelial cells. The LPS-induced increase in lung microvascular permeability as measured by Evans blue extravasation required CXCR2 on nonhematopoietic cells. Our data revealed what we believe to be a previously unrecognized role of endothelial and epithelial CXCR2 in LPS-induced PMN recruitment and lung injury.
Jörg Reutershan, Margaret A. Morris, Tracy L. Burcin, David F. Smith, Daniel Chang, Mary S. Saprito, Klaus Ley
Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO2–) at pH 6.5, which mimics CF airway mucus. Killing required a pH lower than 7, implicating formation of nitrous acid (HNO2) and NO, that adds NO equivalents to cellular molecules. Eighty-seven percent of CF isolates possessed mucA mutations and were killed by HNO2 (3-log reduction in 4 days). Furthermore, antibiotic-resistant strains determined were also equally sensitive to HNO2. More importantly, HNO2 killed mucoid bacteria (a) in anaerobic biofilms; (b) in vitro in ultrasupernatants of airway secretions derived from explanted CF patient lungs; and (c) in mouse lungs in vivo in a pH-dependent fashion, with no organisms remaining after daily exposure to HNO2 for 16 days. HNO2 at these levels of acidity and NO2– also had no adverse effects on cultured human airway epithelia in vitro. In summary, selective killing by HNO2 may provide novel insights into the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways.
Sang Sun Yoon, Ray Coakley, Gee W. Lau, Sergei V. Lymar, Benjamin Gaston, Ahmet C. Karabulut, Robert F. Hennigan, Sung-Hei Hwang, Garry Buettner, Michael J. Schurr, Joel E. Mortensen, Jane L. Burns, David Speert, Richard C. Boucher, Daniel J. Hassett
Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways. This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes transdifferentiation of ciliated to goblet cells. Thus, EGFR blockade (using an irreversible EGFR kinase inhibitor designated EKB-569) prevents virus-induced increases in ciliated and goblet cells whereas IL-13 blockade (using s-IL-13Rα2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell metaplasia. The distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct epithelial architecture in the setting of airway inflammatory disorders characterized by a similar pattern of chronic EGFR activation, IL-13 expression, and ciliated-to-goblet cell metaplasia.
Jeffrey W. Tyner, Edy Y. Kim, Kyotaro Ide, Mark R. Pelletier, William T. Roswit, Jeffrey D. Morton, John T. Battaile, Anand C. Patel, G. Alexander Patterson, Mario Castro, Melanie S. Spoor, Yingjian You, Steven L. Brody, Michael J. Holtzman
Eosinophils cluster around airway nerves in patients with fatal asthma and in antigen-challenged animals. Activated eosinophils release major basic protein, which blocks inhibitory M2 muscarinic receptors (M2Rs) on nerves, increasing acetylcholine release and potentiating vagally mediated bronchoconstriction. We tested whether GW701897B, an antagonist of CCR3 (the receptor for eotaxin as well as a group of eosinophil active chemokines), affected vagal reactivity and M2R function in ovalbumin-challenged guinea pigs. Sensitized animals were treated with the CCR3 antagonist before inhaling ovalbumin. Antigen-challenged animals were hyperresponsive to vagal stimulation, but those that received the CCR3 antagonist were not. M2R function was lost in antigen-challenged animals, but not in those that received the CCR3 antagonist. Although the CCR3 antagonist did not decrease the number of eosinophils in lung tissues as assessed histologically, CCR3 antagonist prevented antigen-induced clustering of eosinophils along the nerves. Immunostaining revealed eotaxin in airway nerves and in cultured airway parasympathetic neurons from both guinea pigs and humans. Both IL-4 and IL-13 increased expression of eotaxin in cultured airway parasympathetic neurons as well as in human neuroblastoma cells. Thus, signaling via CCR3 mediates eosinophil recruitment to airway nerves and may be a prerequisite to blockade of inhibitory M2Rs by eosinophil major basic protein.
Allison D. Fryer, Louis H. Stein, Zhenying Nie, Damian E. Curtis, Christopher M. Evans, Simon T. Hodgson, Peter J. Jose, Kristen E. Belmonte, Erin Fitch, David B. Jacoby
Airway smooth muscle (ASM) growth contributes to the mechanism of airway hyperresponsiveness in asthma. Here we demonstrate that CD4+ T cells, central to chronic airway inflammation, drive ASM remodeling in experimental asthma. Adoptive transfer of CD4+ T cells from sensitized rats induced an increase in proliferation and inhibition of apoptosis of airway myocytes in naive recipients upon repeated antigen challenge, which resulted in an increase in ASM mass. Genetically modified CD4+ T cells expressing enhanced GFP (EGFP) were localized by confocal microscopy in juxtaposition to ASM cells, which suggests that CD4+ T cells may modulate ASM cell function through direct cell-cell interaction in vivo. Coculture of antigen-stimulated CD4+ T cells with cell cycle–arrested ASM cells induced myocyte proliferation, dependent on T cell activation and direct T cell–myocyte contact. Reciprocally, direct cell contact prevented postactivation T cell apoptosis, which suggests receptor-mediated T cell–myocyte crosstalk. Overall, our data demonstrate that activated CD4+ T cells drive ASM remodeling in experimental asthma and suggest that a direct cell-cell interaction participates in CD4+ T cell regulation of myocyte turnover and induction of remodeling.
David Ramos-Barbón, John F. Presley, Qutayba A. Hamid, Elizabeth D. Fixman, James G. Martin
Hyperoxic acute lung injury (HALI) is characterized by a cell death response with features of apoptosis and necrosis that is inhibited by IL-11 and other interventions. We hypothesized that Bfl-1/A1, an antiapoptotic Bcl-2 protein, is a critical regulator of HALI and a mediator of IL-11–induced cytoprotection. To test this, we characterized the expression of A1 and the oxygen susceptibility of WT and IL-11 Tg(+) mice with normal and null A1 loci. In WT mice, 100% O2 caused TUNEL+ cell death, induction and activation of intrinsic and mitochondrial-death pathways, and alveolar protein leak. Bcl-2 and Bcl-xl were also induced as an apparent protective response. A1 was induced in hyperoxia, and in A1-null mice, the toxic effects of hyperoxia were exaggerated, Bcl-2 and Bcl-xl were not induced, and premature death was seen. In contrast, IL-11 stimulated A1, diminished the toxic effects of hyperoxia, stimulated Bcl-2 and Bcl-xl, and enhanced murine survival in 100% O2. In A1-null mice, IL-11–induced protection, survival advantage, and Bcl-2 and Bcl-xl induction were significantly decreased. VEGF also conferred protection via an A1-dependent mechanism. In vitro hyperoxia also stimulated A1, and A1 overexpression inhibited oxidant-induced epithelial cell apoptosis and necrosis. A1 is an important regulator of oxidant-induced lung injury, apoptosis, necrosis, and Bcl-2 and Bcl-xl gene expression and a critical mediator of IL-11– and VEGF-induced cytoprotection.
Chuan Hua He, Aaron B. Waxman, Chun Geun Lee, Holger Link, Morgan E. Rabach, Bing Ma, Qingsheng Chen, Zhou Zhu, Mei Zhong, Keiko Nakayama, Keiichi I. Nakayama, Robert Homer, Jack A. Elias
Mechanisms underlying airway hyperresponsiveness are not yet fully elucidated. One of the manifestations of airway inflammation is leakage of diverse plasma proteins into the airway lumen. They include fibrinogen and thrombin. Thrombin cleaves fibrinogen to form fibrin, a major component of thrombi. Fibrin inactivates surfactant. Surfactant on the airway surface maintains airway patency by lowering surface tension. In this study, immunohistochemically detected fibrin was seen along the luminal surface of distal airways in a patient who died of status asthmaticus and in mice with induced allergic airway inflammation. In addition, we observed altered airway fibrinolytic system protein balance consistent with promotion of fibrin deposition in mice with allergic airway inflammation. The airways of mice were exposed to aerosolized fibrinogen, thrombin, or to fibrinogen followed by thrombin. Only fibrinogen followed by thrombin resulted in airway hyperresponsiveness compared with controls. An aerosolized fibrinolytic agent, tissue-type plasminogen activator, significantly diminished airway hyperresponsiveness in mice with allergic airway inflammation. These results are consistent with the hypothesis that leakage of fibrinogen and thrombin and their accumulation on the airway surface can contribute to the pathogenesis of airway hyperresponsiveness.
Scott S. Wagers, Ryan J. Norton, Lisa M. Rinaldi, Jason H.T. Bates, Burton E. Sobel, Charles G. Irvin
To determine the role of IL-5 in airway remodeling, IL-5–deficient and WT mice were sensitized to OVA and challenged by repetitive administration of OVA for 3 months. IL-5–deficient mice had significantly less peribronchial fibrosis (total lung collagen content, peribronchial collagens III and V) and significantly less peribronchial smooth muscle (thickness of peribronchial smooth muscle layer, α-smooth muscle actin immunostaining) compared with WT mice challenged with OVA. WT mice had a significant increase in the number of peribronchial cells staining positive for major basic protein and TGF-β. In contrast, IL-5–deficient mice had a significant reduction in the number of peribronchial cells staining positive for major basic protein, which was paralleled by a similar reduction in the number of cells staining positive for TGF-β, suggesting that eosinophils are a significant source of TGF-β in the remodeled airway. OVA challenge induced significantly higher levels of airway epithelial αVβ6 integrin expression, as well as significantly higher levels of bioactive lung TGF-β in WT compared with IL-5–deficient mice. Increased airway epithelial expression of αVβ6 integrin may contribute to the increased activation of latent TGF-β. These results suggest an important role for IL-5, eosinophils, αVβ6, and TGF-β in airway remodeling.
Jae Youn Cho, Marina Miller, Kwang Je Baek, Ji Won Han, Jyothi Nayar, Sook Young Lee, Kirsti McElwain, Shauna McElwain, Stephanie Friedman, David H. Broide
Acute lung injury syndromes remain common causes of morbidity and mortality in adults and children. Cellular and physiologic mechanisms maintaining pulmonary homeostasis during lung injury remain poorly understood. In the present study, the Stat-3 gene was selectively deleted in respiratory epithelial cells by conditional expression of Cre-recombinase under control of the surfactant protein C gene promoter. Cell-selective deletion of Stat-3 in respiratory epithelial cells did not alter prenatal lung morphogenesis or postnatal lung function. However, exposure of adult Stat-3–deleted mice to 95% oxygen caused a more rapidly progressive lung injury associated with alveolar capillary leak and acute respiratory distress. Epithelial cell injury and inflammatory responses were increased in the Stat-3–deleted mice. Surfactant proteins and lipids were decreased or absent in alveolar lavage material. Intratracheal treatment with exogenous surfactant protein B improved survival and lung histology in Stat-3–deleted mice during hyperoxia. Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury.
Isamu Hokuto, Machiko Ikegami, Mitsuhiro Yoshida, Kiyoshi Takeda, Shizuo Akira, Anne-Karina T. Perl, William M. Hull, Susan E. Wert, Jeffrey A. Whitsett
β-adrenergic receptors (βARs) relax airway smooth muscle and bronchodilate, but chronic β-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated βAR genes (βAR–/–) and transgenic mice overexpressing airway smooth muscle β2AR (β2AR-OE) representing two extremes: absence and persistent activity of airway βAR. Unexpectedly, βAR–/– mice, lacking these bronchodilating receptors, had markedly decreased bronchoconstrictive responses to methacholine and other Gq-coupled receptor agonists. In contrast, β2AR-OE mice had enhanced constrictive responses. Contraction to permeabilization with β-escin was unaltered by gene ablation or overexpression. Inositol phosphate accumulation by Gq-coupled M3-muscarinic, thromboxane-A2, and 5-HT2 receptors was desensitized in airway smooth muscle cells from βAR–/– mice and sensitized in cells from β2AR-OE mice. Thus, βAR antithetically regulates constrictive signals, affecting bronchomotor tone/reactivity by additional means other than direct dilatation. Studies of signaling elements in these pathways revealed the nodal point of this cross talk as phospholipase C-β1, whose expression was altered by βAR in a direction and magnitude consistent with the physiologic and cellular responses. These results establish a mechanism of the β-agonist paradox and identify a potential asthma modifier gene (phospholipase C-β1), which may also be a therapeutic target in asthma when chronic β-agonists are required.
Dennis W. McGraw, Khalid F. Almoosa, Richard J. Paul, Brian K. Kobilka, Stephen B. Liggett
Strategies to stimulate endogenous surfactant production require a detailed understanding of the regulation of lipogenesis in alveolar type II cells. We developed culture conditions in which keratinocyte growth factor (KGF) stimulates fatty acid and phospholipid synthesis. KGF stimulated acetate incorporation into phosphatidylcholine, disaturated phosphatidylcholin, and phosphatidylglycerol more than 5% rat serum alone. To determine the mRNA levels of lipogenic enzymes and transport proteins, we analyzed gene expression by oligonucleotide microarrays. KGF increased the mRNA levels for fatty acid synthase, stearoyl-CoA desaturase-1 (SCD-1), and epidermal fatty acid–binding protein more than rat serum alone. In addition, KGF increased the mRNA levels of the transcription factors CCAAT/enhancer-binding protein α (C/EBPα) and C/EBPδ as well as SREBP-1c (ADD-1), but not PPARγ. These changes in C/EBPα and C/EBPδ were confirmed by in situ hybridization. SCD-1 was also found to be highly expressed in alveolar type II cells in vivo. Furthermore, KGF increased protein levels of fatty acid synthase, C/EBPα, C/EBPδ, SREBP-1, epidermal fatty acid–binding protein, and SCD. Finally, the liver X receptor agonist T0901317 increased acetate incorporation and SREBP-1 but not SREBP-2 protein levels. In summary, KGF stimulates lipogenesis in type II cells by a coordinated expression of lipogenic enzymes and transport proteins regulated by C/EBP isoforms and SREBP-1c.
Robert J. Mason, Tianli Pan, Karen E. Edeen, Larry D. Nielsen, Feijie Zhang, Malinda Longphre, Michael R. Eckart, Steven Neben


text: I`m currently operating Windows XP Home Edition version 2002. This week i`m buying a new computer which will have Windows 7 on it. In my current XP are the games i.e. Start>all programs>games>listed games. In the new Windows 7 will the same games be on there particularly the 3D Pinball and if not can they be transferred from the previous computer to the new one that has Windows 7, ?? I`ve included some attachments. Thank You


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TripAdvisor Reviews Comfort Hotel Komatsu
Travel Blogs from Seville
Sparkling Sevilla - the soul of Spain
... from side to side, but forward and back as well ( in case you wanted to open the window over the sink). Since we had 5 days, we just settled in for the evening, having picked up some groceries at the nearby Supermercado and bakery. The next day we embarked upon our initial exploration of Sevilla, beginning with the obligatory Starbucks stop. The Seville Cathedral is the third largest in Europe, after St. Paul's in London and St. Peter's in Rome. As with many ...
Group entry: Driving, Seville, heat, driving
... Morocco and get to see a closer view of the Rock of Gibraltar.
A great quote from the Alchemist (Paul Coelho), one of Ibe's favorite books, which is written about the areas we are going to see on this leg of the trip:
"...making a decision was only the beginning of things. When someone makes a decision, he is really diving into a strong current that will carry him to places he had never dreamed of when he first made the decision."
Sevilla's Cathedral
... the cathedral, this post would be a book. A couple highlights were the Giralda Tower, the High Alter and the Tomb of Columbus. We did the tower first, as was recommended by the cathedral staff, especially with the boys. It is a 330ft climb up through spiraling ramps (about 35 of them) to the top. The views are amazing and there are 24 bells that seem to ring at sporadic times. At the very top of the tower is a 4,500lb bronze statue ...
Yesterday was a blog free day!
... Justa Station in Seville just after 1000hrs and despite some poor Spanish on our part we were soon clutching our TGV tickets that would whisk us the 141km in just 40 minutes. At times we hit 250kph! TIME UPDATE: 1015hrs - Train 2102 (AVE Class to Madrid Atocha - 2hrs 30 mines) glides out of the station. No garlic in air as I think back to my parents tales from the 1950's. This is a serious bit of modern kit that even makes Eurostar look a football ...
... him in Germany and borrow his hair dryer.
Anyway back to the story. Strolling along the river we were starting to notice that Seville is possibly the cleanest, prettiest city we had seen, potentially overtaking Istanbul. We didn't see everything along the foreshore that night, but we are so glad we went back the next day to see Plaza de Espa�a and the Maria Luisa Park. Wow! As I said we missed it that night as we were in a hurry to catch a Flamenco show in this old shed full ...


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|Hasan ibn Ali an important figure in Islam. He is the son of Ali and Fatimah. The latter is the daughter of the Islamic prophet Muhammad. After his father's death, he briefly succeeded him as the Caliph , before retiring to Madinah and entering into an agreement with the first Umayyad ruler, Muawiyah ibn Abi Sufyan, who assumed the Caliphate. Hasan is one of the five people of the Ahl al-Kisa, as well as a member of the Ahl al-Bayt. Hasan ibn Ali is 2nd Imam of Shia Islam. Hasan is also highly respected by the Sunni as the grandson of Muhammad
|Abu Ma'shar al-Balkhi an astrologer, astronomer, and Islamic philosopher, thought to be the greatest astrologer of the Abbasid court in Baghdad. He was not a major innovator and as an astrologer he was not intellectually rigorous. Nevertheless, he wrote a number of practical manuals on astrology that profoundly influenced Muslim intellectual history and, through translations, that of western Europe and Byzantium
|Sverre of Norway the King of Norway from 1184 to 1202. He married Margareta Eriksdotter, the daughter of the Swedish king Eric IX, by whom he had the daughter Kristina Sverresdotter
|Jan Želivský a Czech priest and a radical representative of the Hussite Reformation.
|Frances of Rome an Italian saint who was a wife, mother, mystic, organizer of charitable services and a Benedictine oblate who founded a religious community of oblates, who share a common life without religious vows.
|Leonardo Bruni an Italian humanist, historian and statesman. He has been called the first modern historian
|Catherine of Bologna an Italian cloistered nun, artist and saint.
|Henry IV Duke of Mecklenburg from 1422 to 1477 Duke of Mecklenburg.
|Margaret of Savoy Countess of Saint-Pol the eldest surviving daughter of Louis, Duke of Savoy. She was the wife of Margrave John IV of Montferrat and later the wife of Pierre II de Luxembourg, Count of Saint-Pol, of Brienne, de Ligny, Marle and Soissons. Margaret's numerous descendants included Mary, Queen of Scots, and King Henry IV of France
|David Rizzio an Italian courtier, born close to Turin, a descendant of an ancient and noble family still living in Piedmont, the Riccio Counts de San Paolo et Solbrito, who rose to become the private secretary of Mary, Queen of Scots. Mary's husband, Lord Darnley, is said to have been jealous of their friendship, because of rumours that he had made Mary pregnant, and joined in a conspiracy of Protestant nobles, led by Patrick Ruthven, 3rd Lord Ruthven, to murder him. The murder was the catalyst for the downfall of Darnley and had serious consequences for Mary's subsequent career
|Pomponio Amalteo an Italian painter of the Venetian school.
|Alonso de Ribera a Spanish soldier and twice Spanish royal governor of Chile.
|Henry Rich 1st Earl of Holland an English courtier, peer and soldier. A member of the influential Rich family, he was the son of Robert Rich, 1st Earl of Warwick, and his wife, Penelope Devereux, and the younger brother of Robert, 2nd Earl of Warwick
|Arthur Capell 1st Baron Capell of Hadham an English politician who sat in the House of Commons from 1640 until 1641 when he was raised to the peerage as Baron Capell. He supported the Royalist cause in the English Civil War and was executed on the orders of parliament in 1649
|James Hamilton 1st Duke of Hamilton a Scottish nobleman and influential political and military leader during the Wars of the Three Kingdoms.
|Pedro de Toledo 1st Marquis of Mancera a Spanish nobleman general, colonial administrator, and diplomat who served as Viceroy of Galicia and Peru from December 18, 1639 to September 20, 1648.
|Cardinal Mazarin an Italian cardinal, diplomat, and politician, who served as the chief minister of France from 1642 until his death. Mazarin succeeded his mentor, Cardinal Richelieu. He was a noted collector of art and jewels, particularly diamonds, and he bequeathed the "Mazarin diamonds" to Louis XIV in 1661, some of which remain in the collection of the Louvre museum in Paris. His personal library was the origin of the Bibliothèque Mazarine in Paris
|Claude Mellan a French engraver and painter.
|Johann Pachelbel a German composer, organist and teacher who brought the south German organ tradition to its peak. He composed a large body of sacred and secular music, and his contributions to the development of the chorale prelude and fugue have earned him a place among the most important composers of the middle Baroque era
|Ralph Montagu 1st Duke of Montagu an English courtier and diplomat.
|Ernest Frederick I Duke of Saxe-Hildburghausen a duke of Saxe-Hildburghausen.
|Margravine Friederike of Brandenburg-Schwedt Duchess of Württemberg and ancestor to many European royals of the 19th and 20th century.
|Friedrich Wilhelm von Erdmannsdorff a German architect and architectural theoretician, and one of the most significant representatives of early German Neoclassicism. His work included Wörlitz House in Wörlitzer Park near Dessau, one of the earliest classical houses on the European continent. His most well-known student was Friedrich Gilly, the teacher of Karl Friedrich Schinkel
|Federico Carlos Gravina y Nápoli a Spanish Admiral during the American Revolution and Napoleonic Wars. He died of wounds sustained during the Battle of Trafalgar. Spanish explorer Jacinto Caamaño named the Gravina Island in Alaska in his honor
|Joseph Bonomi the Elder an Italian architect and draughtsman notable for his activity in England.
|Ozias Humphry a leading English painter of portrait miniatures, later oils and pastels, of the 18th century. He was elected to the Royal Academy in 1791, and in 1792 he was appointed Portrait Painter in Crayons to the King
|Nicholas Pocock a British artist best known for his many detailed paintings of naval battles during the age of sail.
|Edward Daniel Clarke an English naturalist, mineralogist and traveller.
|Jean Henri van Swinden a Dutch mathematician and physicist who taught in Franeker and Amsterdam.
|Anna Laetitia Barbauld a prominent English poet, essayist, literary critic, editor, and children's author.
|Antoine Destutt de Tracy a French Enlightenment aristocrat and philosopher who coined the term "ideology".
|Charles Lallemand now Texas, and finally returned to France to serve as governor of Corsica.
|George Gleig a Primus of the Scottish Episcopal Church.
|Pierre Dupont de l'Étang a French general of the French Revolutionary and Napoleonic Wars, as well as a political figure of the Bourbon Restoration.
|Christian August Pohlenz a German composer and conductor.
|Otto Pfeilizer-Frank Baron Otto Wilhelm Hermann von Pfeilitzer gen. Franck, sometimes referred to as Otto Romanovich Franck or Otto Romanovich Pfeilitzer-Franck was a Russian statesman, the 6th governor of Taganrog
|Mary Anning a British fossil collector, dealer, and palaeontologist who became known around the world for important finds she made in Jurassic marine fossil beds in the cliffs along the English Channel at Lyme Regis in the county of Dorset in Southwest England. Her work contributed to fundamental changes in scientific thinking about prehistoric life and the history of the Earth
|Hans Christian Ørsted a Danish physicist and chemist who discovered that electric currents create magnetic fields, an important aspect of electromagnetism. He shaped post-Kantian philosophy and advances in science throughout the late 19th century
|Dominic Savio an Italian adolescent student of Saint John Bosco. He was studying to be a priest when he became ill and died at the age of 14, possibly from pleurisy
|Princess Sophie of Saxony the eighth and youngest child of John of Saxony and his wife Amalie Auguste of Bavaria and a younger sister of Albert of Saxony and George of Saxony. Through her marriage to Duke Karl-Theodor in Bavaria, Sophie was a member of the House of Wittelsbach and a Duchess in Bavaria
|Théodore Labarre a French harpist and composer. He lived in Paris and in London and was awarded the Prix de Rome in 1823 as well as the Légion d'honneur in 1862. He was a professor of harp at the Conservatoire de Paris since 1867
|Charles Knight (publisher) an English publisher, editor and author.
|Jules Bourcier a French naturalist.
|Mirza Fatali Akhundov a celebrated Azerbaijani author, playwright, philosopher, and founder of modern literary criticism, "who acquired fame primarily as the writer of European-inspired plays in the Azeri Turkic language". Akhundzade singlehandedly opened a new stage of development of Azerbaijani literature and is also considered one of the founders of modern Iranian literature. He was also the founder of materialism and atheism movement in Azerbaijan and one of forerunners of modern Iranian nationalism
|Caroline Amalie of Augustenburg queen consort of Denmark as the second spouse of King Christian VIII between 1839 and 1848.
|Giovanni Lanza an Italian politician and the eighth Prime Minister from 1869 to 1873.
|Arnold Toynbee a British economic historian also noted for his social commitment and desire to improve the living conditions of the working classes.
|William S. Clark a professor of chemistry, botany and zoology, a colonel during the American Civil War, and a leader in agricultural education. Raised and schooled in Easthampton, Massachusetts, Clark spent most of his adult life in Amherst, Massachusetts. He graduated from Amherst College in 1848 and obtained a doctorate in chemistry from Georgia Augusta University in Göttingen in 1852. He then served as professor of chemistry at Amherst College from 1852 to 1867. During the Civil War, he was granted leave from Amherst to serve with the 21st Regiment Massachusetts Volunteer Infantry, eventually achieving the rank of colonel and the command of that unit
|Carolyne zu Sayn-Wittgenstein a Polish noblewoman who pursued a forty-year liaison/relationship with Franz Liszt. She was also an amateur journalist and essayist and it is conjectured that she did much of the actual writing of several of Liszt's publications, especially his Life of Chopin. She pursued an enormous correspondence with Liszt and many others which is of vital historical interest. She admired and encouraged Hector Berlioz, as is clear from their extensive correspondence. Berlioz dedicated Les Troyens to Princess Carolyne. She was portrayed by Capucine in the 1960 film Song Without End
|William I German Emperor the King of Prussia and the first German Emperor , as well as the first Head of State of a united Germany. Under the leadership of William and his Minister President Otto von Bismarck, Prussia achieved the unification of Germany and the establishment of the German Empire. Despite his long support of Bismarck as Minister President, however, William held strong reservations about some of Bismarck's more reactionary policies, including his anti-Catholicism and tough handling of subordinates. Contrary to Bismarck, William was described as polite, gentlemanly, and while a staunch conservative, more open to certain classical liberal ideas than his grandson Wilhelm II