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Comics Movies Games Blog
Will Game of Thrones Jump the Shark?
Spoilers for Game of Thrones Seasons 1-5 Last season a myriad number of massive thrones plots came together in what amounted to an underwhelming finale. Stannis was instantly punished for his sins. Reek...
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Batman V Superman Review
In a strange twist of fate, it seems like the overly harsh critics who have been ripping Batman V Superman to shreds have actually created positive fan reactions. The first reason for this...
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Daredevil Season 2
Season 1 of Daredevil changed the way comics can be portrayed on television when not limited by networks. Everything from the character arcs to the fight choreography was nearly flawless. With all that,...
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Which Game of Thrones Board Game is Best?
Way back in the spring of 2015 I was desperate to play a version of Risk with the Westeros and Essos maps from Game of Thrones (GoT). I had first been introduced to...
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Life is Strange
I really wanted to like this game. While it's not a game in the traditional sense, the industry has evolved to the point where we have games like Life is Strange. I hopped...
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The Revenant
Making a movie with little dialogue that can keep the attention of the audience should be a near impossible task. Yet Alejandro Iñárritu and his crew manage to make a beautiful masterpiece that...
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David Bowie: A Man of Characters
David Bowie started acting early in his career. He created the persona of Ziggy Stardust as part of his album Ziggy Stardust and the Spiders from Mars. He then spent months living in...
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Star Wars Episode III: Revenge of the Sith
The transformation is almost complete as Anakin struggles to figure out how to keep his visions of Padme dying during childbirth from coming true. I do have to say the acting in this...
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Star Wars Episode II: Attack of the Clones
Episode II picks up about a decade after Episode I. Anakin has a full on rat-tail and is now Obi-Wan's young padawan. The back-and-forth banter between the two is one of the best...
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Star Wars Episode I: The Phantom Menace
For what it's worth, the prequels weren't as bad as most people think. The acting for the most part was okay with what was given to them. The weakest parts being those involving...
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Trailer Wars
In the last few weeks we've seen three trailers released for three separate comic book franchises. First came Captain America: Civil War with emotion, Second, came Batman V. Superman: Dawn of Justice with...
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Blindspot 1×05
It was bound to happen eventually, and this week it took center stage; the CIA and FBI are at odds over Jane and the case of the week. The case being an apparent...
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Heroes Reborn 1×05
The latest Heroes Reborn had some actual slowdown for me. There were some moments, but overall it felt like one of the slowest episodes since the premiere. Acting felt out of place and...
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Blindspot 1×04
They figured out another tattoo! Surprise, surprise, and it led to a case of missing viruses at the CDC. Two rogue scientists who have been planning viral outbreaks to save the future of...


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Christian Ostensen, L.Ac, Dipl.OM (NCCAOM)
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Some of our most asked about procedures: Cupping, Moxibustion, Acupuncture, Chinese Medicine, Herbal Medicine
Areas Served: Manhattan, New York, Union Square, Greenwich Village, NYC, NY, 10003

subset: commoncrawl


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"If confirmed, this discovery of a possible fifth force would completely change our understanding of the universe," said University of California physicist Jonathan Feng
There was something on the canvas underneath the painting -- a blue and black wash? a mistake? another image? -- that was slowly emerging as the oil pants aged
Dark matter is everywhere. Hundreds of millions of dark matter particles pass through Earth every second, but they zip through Earth as if it barely exists
Physicists are Olympians who gaze at the heavens, while those of us on the steppes below occasionally wonder what they're up to.
A spokesman for the team said pentaquarks may help in understanding 'how ordinary matter, the protons and neutrons from which we're all made, is constituted'
The National Post's Ashley Csanady spoke with U of T professor Amanda Peet this week about the theory and how plastic bricks can help illuminate it
Because the discovery of the Higgs completes the Standard Model of particle physics, it is unclear where scientists should look next, or how
A much anticipated announcement from CERN on the existence of the elusive Higgs boson, may have been scooped by an errant video leak.
U.S.-based physicists Monday reported finding strong hints of the Higgs boson, the elusive "God particle" that is believed to give objects mass, but said European data is needed to confirm any potential discovery.
European scientists said Friday they had detected a subatomic particle that sheds light on one of the basic forces of nature which determines the structure of matter


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Owning this home with frontage on the Prairie River will give you time to relax and enjoy fishing in this excellent trout stream, located minutes north of Gleason. The features 3 bedrooms, front and back enclosed porches, large living room, and basement - plus barn all on 2.85 acres, with an estimated 780 feet on Prairie River. Property needs some tender loving care, but all at an affordable price. This information is compiled from miscellaneous sources and is believed accurate but not warranted. Neither the listing broker nor its agents, subagents or property owner is responsible for the accuracy of the information. Buyers are advised to verify all information.
Features Residential
|Style: Ranch
|Lake Chain:
|Garage: 2 Car, Detached
|Lake Name:
|Year Built: 1960
|River Name: PRAIRE RIVER
|Basement Type: Partial Basement, Unfinished
|Water Frontage (feet): 780
|Fin SqFt Total: 1,057
|Lake Size-Acres: 0
|Lot Size: 124146
|High School: LI Merill
|Site Influence: Driveway, River Front
|School District: Merrill Area
|Construction: Frame/Stick


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will greatly multiply your chances of getting interest from other over 50s members on the site. Write about yourself, your pasttimes and upload any nice photos of yourself.
Use our website's state-of-the-art search to locate over 50s members who match your needs. Or just browse through listings and locate members that seem interesting.
Identified someone who could be a good match? Send them a message or just a wink and see what they say. With a little luck you'll be on your way to discovering that special someone for you.
It's really quick


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What is the best treatment for removing scars on the nose (pitted ones)?
Doctor Answers 1
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Pistil Andina Belt - Women's - $37.17
The Fair Trade, Peruvian-made Pistil Women's Andina Belt boasts a gorgeous, hand-embroidered floral design. Sure, it holds your trousers in place or sets off your waistline when you wear a shirtdress ... but it's also a conversation-starter and a piece of art. - $37.17


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I came across this image on Pinterest, on the same day that the Pope excommunicated the entire Mafia from the Roman Catholic Church. Religion can be a powerful force to do harm or to combat those who do harm. And the line between the two sorts of religion is not one that lies between different [Read More…]
Respecting Beliefs
Another Polite Bribe
I had the chance to finish watching the documentary A Polite Bribe, which I blogged about briefly on a previous occasion, and so now want to say more about it. I honestly cannot think of another single documentary film about the Bible which has such a wide array of the very best and best-known scholars [Read More…]
God the Father vs. The Godfather
The discussion of the way some envisage God as running a protection racket led commenter arcseconds to quip "Nice immortal soul you've got there. Pity if something were to happen to it." I thought that deserved to be turned into a meme. Here are a few attempts. Feel free to do better, and if you [Read More…]


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Utforsk lignende emner
Overcoming Seasonal Allergies http://www.draxe.com #health #holistic #natural
Do you suffer from allergies? Many allergies are connected to digestive ill-health. Many individuals with digestive issues suffer from something called "leaky gut", which is associated with many health problems (allergies, delayed food sensitivities, fibromyalgia, inflammation, chronic fatigue, skin issues...the list goes on!) - improving the health of our gut is one key step to helping ease allergy symptoms.
Allergy is characterized by an overreaction of the human immune system to a foreign substance ("allergen") that is eaten, breathed into the lungs, inj
Histamine intolerance infographic http://www.draxe.com #health #Holistic #natural
Allergies and the OTC meds designed for them got you down? Consider a natural approach to get them under control and feel better!
South Carolina Blues - "Allergy-Proof Your Home" Infographic
Best essential oils for allergies - Dr. Axe. Explains why they work and how to use them!
Allergy cross reacting chart: to be honest I'm not sure where she's getting all of this information. It has the info from Cyrex labs for gluten and that is why I have repinned it.
A Juicing Recipe For Allergies: Studies have shown that pineapple, ginger, parsley, and apples all contain either antihistamine properties or anti-allergy abilities or both. This juice recipe for allergy relief contains all of these! :)
Would you like to know 8 things that happen when you drink honey water? You have probably heard some of the benefits of honey already and let's face it, honey sure is tasty I would like to mention though, we're not talking about the cheap honey that you can get. It needs to be organic …


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For any questions related to Cvent, feel free to contact our Customer Care team.
Hotel Weisses Lamm, with its lakeside location, is a quality hotel with all the classic attributes which constitute a hotel in Paznauntal. For those who fancy an ultimate holiday, in the Paznauntal in Tirol even the most pampered guest really gets their money's worth. The hotel offers various fully...
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Men's 5.11 Tactical Short - sleeved Ripstop TDU Shirt
Item # WX2-230672
Men's 5.11 Tactical Short - sleeved Ripstop TDU Shirt
Item # WX2-230672
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Mil-Tec 10-Pc. Riot Suit, BlackBuyer's Club $197.99 Non-Member $219.99
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5.11 Tactical® Short - sleeved Ripstop TDU Shirt. A new class of tough performance, functional design and professional appearance.
Ready for duty, made for today's officer. Over a year of product development went into the design of this 5.11 Tactical Duty Uniform Ripstop Shirt, using input from police officers, special operations operators, and military personnel. The result is a new industry standard in BDU style shirts. Made of tough, polyester / cotton ripstop, the 5.11 TDU® Ripstop Shirt stands up to the rigors of patrol and special operations. Treated for stain and soil resistance, this Shirt stays looking neat, clean and professional for the entire duty shift.Professional, to every last detail:
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- 65% polyester / 35% cotton ripstop. Machine wash / dry. Imported.
State Color and Size, as available in Shopping Cart.
- Reviews
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The Minnesota Vikings have launched their mandatory offseason minicamp.
And veteran cornerback Antoine Winfield isn't there, according to the St. Paul Pioneer Press.
It's unknown at this point whether his absence is excused or unexcused.
If unexcused, he would be subject to fines in the range of $15,000 per day. He also would be subject to a partial signing bonus forfeiture. However, as we recall his contract with the team, he received a large roster bonus in lieu of a signing bonus, since at the time he signed the Vikings had a significant amount of salary cap space.
Though Winfield and the Vikings have been at odds regarding a possible contract extension, teammates expected him to attend the mandatory weekend camp. Absent a new deal, he'll be an unrestricted free agent in 2010.
Winfield Not Present For Mandatory Vikings Minicamp
The Minnesota Vikings have launched their mandatory offseason minicamp.
PackDaddy says: May 29, 2009 5:14 PM
under rated player but fact is he doesn't get many picks. that will hurt his chances for bigger money.
Sundance says: May 29, 2009 6:16 PM
He's out of town attending a funeral of a close friend…..
Dig a bit before you do the "National Enquirer" headlines.
ScottFavre says: May 29, 2009 6:45 PM
Im surprised they didn't post this under the headline
"Winfield Want's a new contract"
like they did with Donald Driver who by the way has practiced in Texas during these OTA's for the last three years and said on the radio today "I am fine with my deal, they just have nothing to talk about"


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Yellow Rice and Fish Fillets Veracruz
42,467pages onAdd New Page
this wiki
this wiki
Description Edit
Makes 4 servings.
Ingredients Edit
- 1 avocado, peeled and finely diced
- 1 tomato, diced (about ¾ cup)
- ¼ cup sliced green onions
- 2 tablespoons lemon juice
- 2 teaspoons vegetable oil
- ¼ teaspoon hot pepper sauce
- ½ teaspoon salt
- 1½ pounds fillets (cod, sole, or halibut)
- 2 teaspoons butter or margarine, melted
- salt and ground black pepper
Yellow rice Edit
- enough rice to make 2 cups cooked
- replace water with chicken broth
- pinch of saffron or ¼ teaspoon turmeric
Directions Edit
- Combine avocado, tomato, onions, lemon juice, oil, pepper sauce and salt; set aside.
- Place on lightly buttered shallow baking pan. Brush with butter; sprinkle with salt and pepper.
- Broil 2 to 3 inches from heat about 5 to 8 minutes or until flakes easily.
- Transfer to serving plate.
- Top with avocado mixture and serve with yellow rice.
- Serve with additional hot pepper sauce, if desired.
Yellow rice Edit
- Cook rice according to package directions using chicken broth and a pinch of saffron or ¼ teaspoon turmeric.


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Need a Lipid Panel Test in Leechburg, PA? Simply order online 24/7 and get a fast, affordable Lipid Panel Test at a lab near you (Find More Locations):
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A Lipid Panel Test is a panel of lab tests that measure the lipid panel. People in Leechburg, PA order the Lipid Panel Test to get a baseline or for ongoing tracking.
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Dave Fleming
|Dave Fleming
November 7, 1969
Jackson Heights, New York
|MLB debut
|August 6, 1991, for the Seattle Mariners
|Last MLB appearance
|September 30, 1995, for the Kansas City Royals
|MLB statistics
|Earned run average
David Anthony Fleming (born November 7, 1969) is a former Major League Baseball pitcher who played from 1991 to 1995, mostly for the Seattle Mariners.
Fleming was born in Jackson Heights, Queens, New York, and went to high school in Mahopac, New York. He pitched for the University of Georgia, leading them to a College World Series title in 1990.[1]
Fleming was selected in the third round of the 1990 Major League Baseball Draft by the Seattle Mariners. He won a career high 17 games, including 9 in a row, for the Mariners in his rookie season of 1992. His ERA that year was 3.39, and he took third place in the AL Rookie of the Year voting (behind winner Pat Listach).
After going 29-15 in his first two MLB seasons, Fleming began to struggle with arm trouble. On 7 July 1995, he was traded by the Mariners to the Kansas City Royals for Bob Milacki. He pitched only 9 games for the Royals before undergoing surgery, and never pitched in the Major Leagues again.
- ^ Street, Jim. "Where've you gone, Dave Fleming?", Seattle Mariners, June 10, 2003. Accessed May 28, 2009. "The ace of the '92 staff was Dave Fleming, a quiet southpaw born in the Jackson Heights section of Queens, N.Y., who went from College World Series star at the University of Georgia to the Major Leagues in a blink of an eye."
External links[edit]
|This biographical article relating to an American baseball pitcher born in the 1960s is a stub. You can help Wikipedia by expanding it.
- 1969 births
- Living people
- Georgia Bulldogs baseball players
- Baseball players from New York
- Major League Baseball pitchers
- People from Jackson Heights, Queens
- People from Mahopac, New York
- Seattle Mariners players
- Kansas City Royals players
- Calgary Cannons players
- Gulf Coast Royals players
- San Bernardino Spirit players
- Jacksonville Suns players
- Pawtucket Red Sox players
- Omaha Royals players
- Rochester Red Wings players
- Newburgh Black Diamonds players
- Waterbury Spirit players
- American baseball pitcher, 1960s births stubs


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Situations I have been in that were worse than this.Mature
I shifted on the trolley as the nurse tapped the back of my hand. Maybe it was the lurid exhaustion or the fact that I had been in pain for hours, but I swear that I could feel the veins blooming against the slap. I was surprised I had any blood left. The pad between my legs was soaking again. I felt the cannula slide in as I counted the two vials worth, hoping she could get what she needed quickly before I began to pass out.
The man in the next cubicle exploded into slurred anger.
'I don't wanna be on this planet anymore, I don't wanna be here. What do have to do to be assessed? What do I have to do? I'll throw myself in front a car, I'll bloody do it, I will, you watch!'
I could hear jostling, the desperation soured by the booze. Telephones jangled while people talked in lowered voices, voices of policemen world weary of this kind of outburst. The man's message was lost in the translation, thick with street drugs and rejection, it was lost before he even opened his mouth.
'I don't wanna be here, I want my kids back, I want the methadone, I wanna get out, I wanna be dead. I wanna be assessed.'
The arc of his voice rang into a sincerity, underneath the chemical oblivion there was a note of true despair. I too wondered what he would have to do for an assessment. I had sat alone and quietly, racked with pain that made me stiffen and cry for breath as the other patients watched me. I wondered whether it was any better to suck air politely or lose it in aggression; which of us was going to get relief first?
The nurse interrupted my daze. She said she was sorry and sure enough the cannula had sprayed my blood over the floor, she mopped at it efficiently, like it was all part of a normal day.
'You're not funny about blood are you?' she asked, I felt obliged to lie and say no as I reeled on the trolley, clutching at oxygen while my eyeballs spiked dots.
I closed my eyes and played the old familiar game. The game of 'Situations I have been in that were worse than this.' I was alone in Casualty, bleeding and racked with pain. So what was worse? Losing my little brother in a department store. Breaking my arm. Being fired from that temp job. Being disowned by my father. My rapist opening up the wounds again, for the hundredth time; not having yet got his kicks, even when I was torn.
Except, that rapist was why I was here. The situation had been in worse than this was the cause of this, even though it happened ten years ago. I'm still in that situation, part of me is hostage there forever. Until moments like this, when she catches up with me and we're bleeding and politely lying to staff in hospitals 'it's not that bad, I'm okay, I'm fine waiting alone.'
The man is hauled off to some cells, the safest place to assess him. Mentally I wish him well and I feel guilty to be glad of the peace and quiet. I go back to lying on the trolley, shifting my hand with the cannula that makes me want to vomit with every twitch.


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Home > Low Fat Recipes II > Fat Free Meatloaf
Fat Free Meatloaf
Low Fat Recipe
There is less than one gram of fat per serving of this Fat Free Meatloaf which, by FDA standards, can be considered no-fat. Just be sure you have the 95-percent fat-free meat - otherwise adjust the fat amount accordingly.
1-1/2 pound 95 percent fat free ground beef
1/2 onion, diced
2 egg whites
1/2 cup oatmeal
1 teaspoon poultry seasoning
1/2 cup water
Recipe Directions
Mix all ingredients together and put in loaf pan. Bake in oven at 350-degrees for approximately 1 to 1-1/2 hour.
There is less than one gram of fat per serving which, by FDA standards, can be considered no-fat.
Nutrition Nibbles
The oatmeal in this meatloaf replaces the usual bread crumbs to lend texure and hold the loaf together. In addition, oatmeal is a good source of fiber, protein, manganese, and selenium. Furthermore, the fiber present in oats and oatmeal is now linked with lower cholesterol levels.
Nutrition Information
Recipe makes 6 servings.


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Drivers in bangor can expect some delays as crews prepare for the opening day at the new Hollywood Slots complex on the Bangor Waterfront..
Traffic during the morning and evening commutes could be a challenge as work winds up along main street.
It's expected to be manageable, but drivers should plan a few extra minutes to move through the area.
The work will be in progress Sunday, Monday and Tuesday.


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In laboratory studies, Lin and colleagues developed and tested a new type of nanoparticle that can deliver larger amounts of a drug and will not leak the drug as the particle circulates through the blood stream on its way to the target.
In the proof-of-concept experiments, they tested the nanoparticle's ability to deliver therapeutic doses of the chemotherapy drug oxaliplatin to colon and pancreatic tumors. The oxaliplatin-based particles showed significant growth inhibition of pancreatic tumors that are extremely difficult to treat. The nanoparticle has two to three times therapeutic efficacy over oxaliplatin.
The nanoparticle is different from other nanoparticles in its very high drug loading and in the ability to release in the chemotherapeutics in a controlled fashion. The release of therapeutic cargoes depends on the naturally occurring molecules that are more abundant in many tumors.
Lin explains, "The polysilsesquioxane (PSQ) particle we have developed carries extremely high loadings of oxaliplatin-based chemotherapeutics. The particles are stable under normal physiological conditions, but can be readily reduced to release the platin cargoes in highly reducing tumor microenvironments that have high concentrations of reducing agents. As a result, they have very little background release and are more easily targeted to tumors than most existing particles. We need to thoroughly determine the pharmacokinetics and other important properties of the PSQparticle in order to translate this particle platform to the clinic."
Other UNC scientists involved in the research are graduate students Joseph Della Rocca, BS; Rachel C. Huxford, MS; and Erica Comstock-Duggan, BS.
This work is supported by 2010 funding from the National Cancer Institute's Cancer Nanotechnology Platform Partnerships and the Carolina Center of Cancer Nanotechnology Excellence. These 12 partnerships and 9 centers were designed to promote and support individual, circumscribed multi-disciplinary research projects that will address major barriers and fundamental questions in cancer using innovative nanotechnology solutions.
Paul A. Godley, MD, PhD, MPP, is Executive Associate Dean for Faculty Affairs and Faculty Development, Professor in the Division of Hematology/Oncology at the University of North Carolina at Chapel Hill School of Medicine, Adjunct Professor in the Department of Epidemiology at the UNC School of Public Health, member of the UNC Lineberger Comprehensive Cancer Center, and a Senior Fellow at the UNC Sheps Center for Health Services Research.]]>
Tammy Allred and Paula Stinson received the 2012 Nursing Excellence Awards, and Frank Simpson and Jennifer Byrd received the 2012 Clinical Services Excellence Award.
Lisa Carey, MD, Physician-in-Chief, N.C. Cancer Hospital, said, "Our nurses and staff are compassionate professionals who care deeply for and about our patients and their families. With such an exemplary group, it's always difficult to decide on recipients for these awards, and we are grateful for the standard of care practiced not only by those honored, but by everyone at the N.C. Cancer Hospital."
Tammy Allred, RN, OCN, is the Oncology Nurse Navigator for the Thoracic and Sarcoma Programs. She has worked with UNC cancer programs for 11 years. A nominator notes, "Tammy gives her all in whatever she does. She is the type of nurse and person you want to care for you when you are sick." Another nominator writes, "She dedicates many volunteer hours to the North Carolina Lung Cancer Partnership that works to educate and de-stigmatize lung cancer and also support research in lung cancer."
Paula Stinson, RN, BSN, CPON, CHTC, is the Pediatric Bone Marrow Transplantation Nurse Coordinator who has been at UNC for seven years. One of her nominators called her "a transplant nurse coordinator to emulate," stating that "Paula exemplifies what a nurse should be: knowledgeable, approachable, efficient, consistently striving for excellence in her role and is an expert in her field," while another described her as "an educator and cheerleader for pediatric transplant recipients as they are admitted and transition into inpatient care."
Jennifer Byrd is an Oncology Patient Coordinator who has worked at UNC for four and a half years. Her nominator states, "Jennifer consistently learns what's special about the people she greets in the Infusion Center and they are just that to her: people- not patients. How lucky we are to call her ours."
Frank Simpson is a Medical Support Assistant for several cancer outpatient clinics who has worked at UNC for eight years. His nominator describes him as "pivotal," and "forward looking, working toward innovation in the clinics." She adds, "All the clinics that he supports feel that he is part of their team. He is where the university and the hospital meet to make this a great service line."
Shelley Earp, MD, Director of UNC Lineberger and UNC Cancer Care, said, "These awards recognize the best of the best. UNC is known for its personalized care, and this year's winners exemplify what we strive to offer patients and families facing cancer."
Tammy Allred and Frank Simpson were unable to attend the recognition ceremony but awards were accepted for them on their behalf.
Winners of the Excellence Awards receive a $1500.00 stipend for professional education activities. The Oncology Nursing Excellence Award is presented in memory of Charmayne S. Gray, an outstanding oncology nurse who died in an auto accident in 2002. The Clinical Services Excellence Awards have been awarded for the past eight years.]]>
"This is an excellent chemical probe," says Jian Jin, PhD, a corresponding author on the study. "We have a great deal of biochemical and cellular data on UNC0638 that shows that it interacts only with the proteins it was meant to and has low toxicity to cells. The combination of high selectivity, robust on-target activity in cells, and low cell toxicity makes UNC0638 a valuable tool for the biomedical community to decipher the role of G9a and GLP in human diseases. Many chemical probes in use today are not as selective."
Jin is an associate director of medicinal chemistry for the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) at the UNC Eshelman School of Pharmacy.
G9a and GLP are relatively new candidates as drug targets and belong to a class of proteins called epigenetic regulators. The proteins control the expression of genes by specifically modifying the histones around which DNA is packaged.
"Epigenetic regulators are what make liver cells liver cells and brain cells brain cells even though all cells contain the same genetic code," says Stephen Frye, PhD, one of the paper's coauthors. "The proteins control what genes are active on a cell-by-cell basis."
Because G9a and GLP are being eyed as potential drug targets, it is important that a chemical probe be specific, says Frye, who is director of the CICBDD and a research professor at the School. The probe has drug-like properties but is much more specific than some drugs.
"As long as a drug is safe and effective, you don't necessarily care what the secondary effects might be as long as they are not harmful," he says. "A probe like UNC0638 has to act cleanly and only interact with proteins it is designed to target. That's the only way you can be certain that any changes you observe were caused by the probe interacting with its target and not by a peripheral interaction you don't know about."
The Structural Genomics Consortium is a public-private partnership promoting the development of new medicines by carrying out basic science of relevance to drug discovery. The core mandate of the SGC is to determine 3D structures of proteins of biomedical importance and proteins that represent potential drug targets. The consortium and its scientists are committed open access and to making their discoveries available without restriction on use. They will not agree to file for patent protection and require the same commitment from any collaborator.
The research team was led by Jin and Cheryl Arrowsmith, PhD, chief scientist of the SGC and a professor at University of Toronto, along with co-first authors Feng Liu, PhD, a postdoctoral research fellow in Jin's lab at the School; and Masoud Vedadi, PhD, a principal investigator at the SGC, and Dalia Barsyte-Lovejoy, an SGC senior scientist.
In addition to Jin, Frye and Liu, the coauthors from UNC-Chapel Hill are Xin Chen; William P. Janzen; Dmitri B Kireev; Jacqueline L Norris; Samantha G. Pattenden; Catherine D. Simpson; and Tim J Wigle of the CICBDD; Thomas J Mangano, Xi-ping Huang, and Bryan L Roth, PhD, of the National Institute of Mental Health Psychoactive Drug Screening Program; and Ashutosh Tripathy of the UNC Macromolecular Interactions Facility.
Coauthors from the SGC are Abdellah Allali-Hassani, Cheryl H Arrowsmith (also with the Ontario Cancer Institute), Peter J Brown, Irene Chau, Aiping Dong, Aled Edwards, Alena Siarheyeva, Wolfram Tempel, and Gregory A. Wasney.
Additional coauthors are Sylvie Rival-Gervier, PhD, of SickKids Hospital in Toronto and INRA of Jouy en Josas, France; Arturas Petronis, MD, PhD, Viviane Labrie, PhD; and Sun-Chong Wang of the Centre for Addiction and Mental Health in Toronto; Peter A. DiMaggio, PhD, and Benjamin A. Garcia, PhD, of Princeton University; James Ellis of SickKids and the University of Toronto.
The project described was funded in part by award number RC1GM090732 from the National Institute of General Medical Sciences, the Carolina Partnership and University Cancer Research Fund from the University of North Carolina at Chapel Hill, the U.S. National Science Foundation, the Ontario Research Fund, the Ontario Ministry of Health and Long-Term Care and the Structural Genomics Consortium.
The article "Cells on the Move" written by Elise Lamar and published in the May 2012 issue of HHMI Bulletin quotes UNC Lineberger member James Bear, PhD, and discusses his research.
Dr. Bear is an associate professor of Cell and Development Biology.
The HHMI Bulletin is a quarterly publication that provides information about the biomedical research and science education programs supported by Howard Hughes Medical Institute.
Read article.]]>
Dr. Evans is a clinical professor in the UNC Department of Genetics and leader of the Clinical Cancer Genetics Program. He is also a member of UNC Lineberger Comprehensive Cancer Center.
Read article.]]>
She says, "I was honored to represent UNC Lineberger at the live SU2C telecast on September 7th. The event featured cancer survivor stories. It was incredibly touching to watch these individuals share their stories and also see them in person and actually stand with them in their fight against cancer. These individuals are fighting so hard for their lives and are seeing positive improvements based on the research funded by SU2C."
Dr. Whitehurst is shown here with her husband, Dr. Jay Whitehurst, and US Olympic gold medalist Gabriella Douglas.
|Dr. Whitehurst with Dr. Jay Whitehurst and Dr. Waun Ki Hong, Head, Department of Cancer Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center and a member of the SU2C Scientific Advisory Council.
With this grant, Dr. Der is planning to test an inhibitor of a protein in the Ras oncoprotein pathway, ERK. His project is designed to predict methods by which pancreatic cancer cells may compensate for ERK inhibition and become resistant to this drug, so that he and his colleagues can devise a strategy to overcome the cells' resistance and ensure that the drug is effective in treating pancreatic cancer.]]>
The award from the National Institute of General Medical Sciences, part of the NIH, is worth approximately $1.2 million over four years.
"Because many serious human illnesses involve RNA components — including the RNA genomes of viruses like HIV and Hepatitis C — the potential impact of this project is exceptionally wide-ranging," Weeks said.
Previously, Weeks and his lab created the first-ever model of an entire HIV-1 genome, a discovery that has widespread implications for understanding how viruses like HIV infect humans.
Weeks is a member of UNC Lineberger Comprehensive Cancer Center.
Read more about Weeks' research at http://www.unc.edu/spotlight/CCM3_021046.]]>
The finding offers a new glimpse into the private lives of stem cells that could help scientists use them to grow new neurons or other cells to replace those that have been lost in patients with Parkinson's and other diseases. "Despite the huge potential of stem cells for therapeutic use, very few people have actually investigated their basic biology," said study senior researcher Mohanish Deshmukh, PhD, professor of cell & developmental biology at the University of North Carolina at Chapel Hill. "These results could have significant implications from a therapeutic perspective".
Of all the important things our bodies' cells do, staying alive is clearly key. But a cell's ability to die when something goes wrong is equally critical. For example, a faulty self-destruct button is one factor that allows cancer cells to proliferate unchecked and cause tumors.
Deshmukh and his colleagues discovered stem cells are extremely sensitive to DNA damage, which can be caused by factors like chemicals, radiation or viruses. The experiment showed that virtually 100 percent of human embryonic stem cells treated with a DNA-damaging drug killed themselves within 5 hours, as compared to 24 hours for other types of cells. "That's an incredibly rapid rate of death," said Deshmukh, who also is a member of the UNC Neuroscience Center and Lineberger Comprehensive Cancer Center.
The hair-trigger suicidal response is an important adaptation for embryonic stem cells, said the UNC School of Medicine researcher, because a slower response could allow DNA damage to proliferate and harm the embryo. "Mutations that develop in these cells could be catastrophic for the developing organism, so it would make sense for these cells to be rapidly eliminated."
The key to the stem cells' quick response is that they pre-activate a critical protein called Bax, the researchers found. In most cells, Bax is is kept in an inactive form, waiting for a long chain of events to rouse it into action if the cell becomes damaged enough to kill itself. In human embryonic stem cells, the team found Bax standing at attention in its active form in the Golgi apparatus, a part of the cell that processes and modifies proteins.
"What these cells do is very clever," said Deshmukh. "They have activated Bax, but they've also parked it in a safe little compartment—the Golgi." If the cell detects DNA damage, Bax zips over to the mitochondrion (the cell's power plant), where it signals other proteins to shut the cell down.
It's like starting a 100-yard race at the 80-yard line, said Deshmukh. You're guaranteed to get to the finish line first because you did most of the work before the race began. However, there are built-in safeguards against a hair trigger activation of death. Pre-activated Bax is housed in the Golgi keeping the protein from accidentally triggering cell death when it's not warranted.
This extreme sensitivity to DNA damage lasts only a few days during early development. After the embryonic stem cells begin differentiating into early progenitors that give rise to specific cell types (like heart cells or skin cells), Bax reverts to its inactive state.
UNC Co-first authors of this study are - Raluca Dumitru and Vivian Gama. Other UNC Co-authors include B. Matthew Fagan, Jacquelyn J Bower, Vijay Swahari and Larysa H Pevny. The study was funded by grants from the National Institutes of Health (National Institute of General Medical Sciences) and UNC's University Cancer Research Fund.]]>
Andrew Wang, MD, assistant professor of radiation oncology and study senior author, explains, "Our study demonstrates the proof of principle of engineering 'smart' therapeutics that can preferentially deliver chemotherapeutic treatment to cancer. Such therapeutics were not possible until the development of nanoparticle therapeutic carriers. These tiny devices can be precisely engineered to carry therapeutic cargo and be targeted to cancer cells. We believe our preclinical study will facilitate the clinical development of these targeted nanoparticle-based treatments and eventually improve cancer treatment. " Wang is a member of UNC Lineberger Comprehensive Cancer Center.
Peritoneal metastasis, when the cancer has spread to the lining of the abdomen, is a major cause of side effects and death in ovarian cancer, and while intraperitoneal chemotherapy and radiotherapy have shown good clinical results, both are limited by their non-targeted nature.
To develop the nanoparticle, the team used folate, a water-soluble form of Vitamin B9 because most ovarian cancers overexpress the folate receptor. The nanoparticles encapsulated the chemotherapy drug Paclitaxel and the yittrium-90 as the therapeutic radioisotope.
Funding for this study was provided by a grant from the North Carolina Triad Chapter of Golfers Against Cancer, a pilot grant from the Carolina Center for Nanotechnology Excellence, and the North Carolina University Cancer Research Fund. Dr. Wang is also supported by a National Institutes of Health grant.
Other UNC scientists involved in the study, all from the UNC Department of Radiation Oncology are Ronald Chen, MD, assistant professor of radiation oncology; Jonathan Copp, BS, research assistant; Natalie Cummings, BS, research assistant Shrirang Karve, PhD postdoctoral fellow; Rohit, Sukamar, BS, research assistant: and first author Michael Werner, PhD, postdoctoral fellow. Tian Zhang, MD, senior medical resident from Duke University Internal Medicine Program was part of the team.
Dr. Wang has a consulting agreement with Samyang Corporation in Korea.]]>
Tori's efforts began when she and her mother, Susan, saw a segment of the "Ellen DeGeneres Show" when Ellen gave $100,000 to a school with a large population of homeless students. DeGeneres' gift was matched by Justin Bieber.
Tori suggested to her mother that the Frahms give $100,000 to someone to help. Instead, Tori's mother called Nicole Pratapas, a major gifts officer at UNC Lineberger Comprehensive Cancer Center
They visited the pediatric oncology clinic the day before Thanksgiving to learn about the clinic and talk with the staff about finding a family to help. Nurse manager Ken Neuvirth, RN, MSN, explained that there were many families who needed help. Tori's mission began: collect and wrap 300-400 gifts for patients and siblings. But she has far surpassed her goal, with 750 gifts.
Tori's family, schoolmates, neighbors, community and friends all contributed to the drive as did UNC Lineberger employees. Nicole Pratapas' mini-van was completely packed, on more than one occasion, with everything from soft cuddly stuffed toys to iTune cards. The wrapped and labeled gifts were organized by age and gender and filled an entire consultation room.
Neuvirth explains, "Sometimes parents of pediatric patients don't have the time, or the funds, to shop for the holidays. These gifts made hundreds of families' holidays brighter."
Parents were invited to visit the room to select a gift for each of their children. One father said, " Thank you. We told our other children that their present this year was their brother still being here so this is really nice."
Susan Frahm said, "When we first spoke about this program, I felt a bit overwhelmed at the thought of coming up with 300 to 400 gifts in such a short time. I wasn't sure Tori and I would meet our goal, but we knew we had to try. I left the hospital after our tour full of emotion. I felt a sadness in my heart for the children and families dealing with illness and having to go through treatments. I can only imagine how scary what they are going through must be. I also felt humbled and encouraged by how positive and cheerful the children and staff seemed."
"I felt fortunate to have a healthy, kind-hearted child and a loving supportive husband. Lastly, I felt a resolve that we had to help, we had to do all that we could to ease the burden for those parents and bring some happiness to those children no matter how daunting the task seemed. I soon learned how fully and wholeheartedly the people of this community would join us in our efforts to make this program a success."
"After the amazing article in the Burlington Times News, the gifts came in by the dozens. Tori and I were more amazed everyday. Friends and strangers alike gave toys, money and their time. I still have a check and a trunk full of toys to deliver to you. Tori and I feel honored that we were able to be a small part of this effort. Our hearts are full this holiday season just knowing that we were able to be the spark that started this program."
Stuart Gold, MD, professor of pediatrics and division chief of pediatric oncology, said, "There are many kind people and families who have gone out of their way throughout the years to support our patients and their families. We are so grateful to each of them for making our patients' journey through the cancer treatment process better. Tori inspired others to join her in making our children's holidays brighter. It is always wonderful when people want to give and it is especially wonderful when it is coming from the heart of an 8-and-a half- year-old girl."
Read related article in the January 2, 2012 issue of The Times News.
Read related article in the December 31, 2012 issue of The Times News.]]>
Pignone and Wheeler are both members of UNC Lineberger Comprehensive Cancer Center.
"Our goal with this study is to understand more fully the numerous conjoined factors that influence decision making around screening for colorectal cancer in underserved populations," said Wheeler. "People living in financially constrained circumstances have many competing demands for their time and money. The risks and rewards of colorectal cancer screening may be weighed differently in underserved populations, given that these folks are weighing not just the benefits of screening, but also (and perhaps more importantly) the cost of a colonoscopy, distance required to travel for the appointment, time lost from work, preparations involved, and many other financial and non-financial tradeoffs."
Colorectal cancer is the third most common cancer diagnosis and second leading cause of cancer-related deaths in the United States. Although overall rates of colorectal cancer screening have increased overall in recent years, screening rates for low-income, uninsured, less educated, minority, and rural-dwelling individuals and communities are lower than the rest of the population. Results from the study will be used to implement effective and efficient programs to reduce differences in screening rates between low income patients and those with higher incomes. Because many low income North Carolinians belong to racial/ethnic minority groups, this study also has the potential to characterize patterns of and uncover reasons for racial/ethnic disparities in screening and cancer outcomes. The study will include male and female North Carolina residents from all racial and ethnic groups ages 50 to 75 and either publicly insured (i.e., Medicare and/or Medicaid) or uninsured. Research will span a period of three years with findings expected to influence intervention strategies at the state level.
The study is based at the UNC Center for Health Promotion and Disease Prevention in Chapel Hill and funded by the Prevention Research Center Program at the Centers for Disease Control and Prevention. For more information please visit the UNC Center for Health Promotion and Disease Prevention's website at www.hpdp.unc.edu.
Founded in 1985, the UNC Center for Health Promotion and Disease Prevention hopes to bring research findings to the daily lives of North Carolina communities and populations vulnerable to disease. HPDP works with the UNC Schools of Dentistry, Medicine, Nursing, Pharmacy and Public Health supplementing research and promoting good health. HPDP receives funding from the Centers for Disease Control and Prevention and was one of the first three Prevention Research Centers.]]>
To better shape the next phase of CER, a team of scientists reviewed literature and conducted interviews with 41 comparative effectiveness researchers at the Agency for Healthcare Research and Quality's Cancer Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Comparative Effectiveness Research Consortium.
Based on these interviews and further analysis, these scientists, members of the AHRQ Cancer DEcIDE Data Committee, developed recommendations to improve, accelerate and implement the use of CER to inform cancer care and clinical practice. The team reports in the April 20, 2012 online issue of the journal Cancer.
Their review includes discussion of data sets with recommendations on how better to identify those that are relevant to addressing individual research questions, and how to evaluate them. It characterizes the explosive growth in information technology and recent advances in research methods, and the large population-based data that are consequently now more available for research. In contrast to data collected for clinical trials, many of these data sets were not initially collected to support research, let alone address specific research questions. For example, the National Cancer Institute's SEER-Medicare data links cancer registry data to administrative and insurance claims data from Medicare. Together they have been used to analyze important questions such as the relative benefits of one type of radiation therapy for prostate cancer compared to another. These and similar data have been used to address a wide range of research questions for which prospective clinical trials are not feasible, practical, or sufficiently timely.
To aid CER researchers, the team conducted interviews and research and identified relevant data sets for cancer CER research. They organized these sets into useful categorical classifications, and presented characterizations of the data and examples of their use. They then propose recommendation to both maximize their immediate utility for CER, and also to inform the development of the next generation of data so that it may be more useful for research.
"We often find that similar concepts are measured in very different ways between data sets, making them difficult to compare in research. One recommendation we have for the CER community is to develop uniform definitions and consistent ways of collecting and coding data so that they can be more useful in research," says Anne-Marie Meyer, PhD, the study's lead author and the UNC Facility Director for the Integrated Cancer Information and Surveillance System (ICISS) at UNC Lineberger Comprehensive Cancer Center. "Longer-established systems also need to be enhanced to extend their ability to answer important questions in the context of contemporary cancer care." She is an epidemiologist research associate at UNC Lineberger.
The authors cite a need to establish systematic, standardized measures of collection and coding of data, pointing out that the lack of global standardization inhibits data pooling, comparability among multiple sources, and the ability to generalize findings in the context of the population's diversity.
Bill Carpenter, PhD, assistant professor of health policy and management at the UNC Gillings School of Global Public Health, and UNC PI for the AHRQ-funded Cancer DEcIDE CER Consortium, explains, "In addition, we need to develop a forum and a process for overcoming issues of data ownership, access, and governance. Much data is currently proprietary, and so the process of gaining access to them is bureaucratically cumbersome and time consuming. As a result, the majority of time in a research project is spent gaining access to data rather than examining them and answering important questions that can improve patient care quality and cancer outcomes." He is faculty director for ICISS.
The reviewers suggest strategies such as enhancing national cancer registries' collection of data on genetic markers; increasing transferability of data with open-source, open-access tools; and more intermediate outcomes such as time to disease progression or recurrence, toxicities, and treatment side-effects.
They recommend improving study design and population sampling and developing methods to leverage existing data.
Dr. Meyer notes, "It is important to recognize that new methods can extend the utility of existing data, but they cannot always correct for problems in the way data were collected. Only through improvements in study design and dataset development can some of these barriers be overcome. As such, new efforts to develop extensive new data would be well-served to incorporate diverse research perspectives, including those of methodologists. Many limitations or data errors can be corrected up-front and ensure that these data will be useful in the future."
Addressing these recommendations will not necessarily be easy, and may involve changing longstanding paradigms in data ownership and governance. The team points out the need for developing codified relationships among federal agencies, their contractors and many data holders to facilitate timely data sharing for research that supports the public good. Standardized relationships between state and federal agencies help reassure data holders that their data will be used appropriately and will facilitate the timeliness of data for research and enable quick turn-around on important questions.
"With the internet, we have seen an astounding democratization of information. In this context, data liquidity should be our new standard: we should aspire to create new data that can be used broadly, by many audiences, to address many questions. As this happens, competitive advantage among researchers and research organizations will no longer be a function of 'who owns the data,' and will instead become, 'Who can articulate the important questions, and appropriately and expeditiously analyze the data to correctly answer them?'" says Carpenter.
They underscore the need for improved access to data, but recognize the critical concern for data security, privacy and confidentiality.
Carpenter continues, "Data security and the privacy and confidentiality of the individuals whose data are collected must remain paramount. But we must be thoughtful about this. We cannot set up systems that so emphasize these needs as to be impractical and thus not useable. To be successful here, we must incorporate both technological and administrative systems to protect the data, but we must also emphasize the importance of building and protecting an essential trust fabric between the people whose data are collected, the data collectors, and the researchers. No successful relationship can get off the ground without trust, or be perpetuated without steadfast stewardship."
Their final recommendation describes the advantages of a collaborative, multidisciplinary approach to represent and articulate the different approaches, cultures, terminology, measures, and priorities for cancer CER. Research must move beyond the silos. They cite the recently established Patient Centered Outcomes Research Institute (PCORI) as the obvious choice to lead such an effort.
Meyer concludes, "In recognition of the value and importance of CER, the Patient Centered Outcomes Research Institute (PCORI) was created as a hub of CER and a center for leading and coordinating the national discussion on it. Though still in its formative stages, it has advanced very quickly under the leadership of Dr. Joe Selby. It has recently revised its initial research agenda, and is expected to begin engaging researchers in important CER in the very near future. UNC has been in consistent contact with the founding members of PCORI and, with Dr. Ethan Basche – a member of the PCORI Methods Committee – joining the UNC faculty in the next few months, we look forward to continuing to engage in this discussion, contribute to this important research, and develop new knowledge to help patients make the best health care decisions possible given their specific needs and priorities."
Additional study authors are Amy P. Abernethy, MD, Duke University; Til Sturmer, MD, PhD, UNC; and Michael Kosorok, PhD, UNC.]]>


text:
|The top section of the garden under which lies many loads
of soil and builder's hardcore to level out the original drop.
|The Dell - the lower section of the garden
ilustrating how much the level was originally raised.
familiar with the smaller cousin).
|Candelabra Primulas happy in their habitat -
the original plant is on the left.
extremely popular with the Janet and Chris' grandchildren who use it for building camps and generally getting away from the adults.
|More of the Primulas downstream, showing how a happy
plant will thrive given the right conditions,
|Shuttlecock Ferns are a striking feature of the area,
standing up to four feet high
|The vegetable area needs to have deer protection.
|Woodland camps - a plus for younger members of the family!
|And finally ... what Sunday afternoon garden visit
would be complete without cakes?


text:
Hotel Internacional Managua
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- Free High-Speed Internet
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Day 2 Nicaragua mission with RHEMA
... 8221; for her salvation. I was so happy to share that her salvation was guaranteed and a free gift of God just as her Bible was a free gift from us. I feel like I gained a new sister as the joy of the Good News flooded her heart. Divine appoints are appearing all over the place as we talk with each other and see how God has brought us together for such a time as this! Maranatha, Mary ...
Hello Nicaragua!
... and met a young surfer couple from Oregon. They invited me to join them and we talked about all kinds of things for a couple of hours. Finally, they bailed out on Happy Hour and headed off for a horse-drawn carriage ride. That seems to be the thing to do here. I don't think that I will do it. I see lots of working, horse-drawn carts on the streets in town. One of my biggest concerns in our conversation was when Alex said she had contracted ...
Bienvenido a Nicaragua
... destination. Leah was in her early 20s and travelling for the first time by herself in a country and language of which she didnt know. She seemed relieved to meet people she could converse with. Our hostel in managua was absolutely charming and very decently comfortable considering the absence of a/c and hot water. The hostel had a chihuahua named Sophia - she was our little guard dog.
The very next morning, after a couple of hours of orientation, we were headed out to take ...
Adios America, hola Nicaragua
... brow and pushing our bikes onto the ferry as the anchor was lifted. The roads had been tough and we weren't looking forward to the ride home later on. The short ferry ride provided beautiful views of the city and soon we were stepping on the island and cycling by another large naval base and many beautiful houses. We reached the beach in time to enjoy our final US Pacific sunset with our trusty bikes not too far away. After taking in the sunset we cycled back to ...
Relaxation Roller Coaster
... the city, I stayed back to protect our stuff (and by that I mean I sat down and fell asleep right when we got there). The following day we checked out a local bakery called Pan de Vida ran by a couple from Canada that gave us some amazing baked goods as well as advice on what to do in Granada (to be honest there may have been more than one trip to the bakery, 2 mmm cough 4, and one shameful walk by where we thought about going in but didn't). Per the bakery ...


text:
Giro Revolver Helmet - $34.95
Giro Revolver Helmet - A durable, hard shell helmet with just the right amount of brim and style. The super fit engineering technology will give you the fit and performance at the highest level. Hard Shell Construction is a process which molds a hard outer shell and then attaches it to the EPS foam liner. For a custom fit, the In form fit system allows you to adjust this helmet via the dial at the base of the helmet that will give you stability while the vertical tuning feature accommodates different goggles and head shapes for that one of a kind fit just for you. The interior sub liner will allow for you to customize your pads by pulling them out completely, or adjusting them for the ultimate in rider fit. This Revolver Helmet by Giro is the perfect park and pipe with its 6 super cool vents with mesh covers that will pull cool, fresh air into this helmet as the heat and warm air are pushed out, this helps to regulate your core temperature keeping you fresh and comfortable all day long. Your goggles will also be fog free, this is done by aligning the stack vent in the helmet with the center vent of your goggles. The warm air escapes from the center top vent keeping you at a regulated temperature while your goggles stay clear as you are dialed into your set up if you are hard core boarder or an advanced skier. Giro has designed this high performance helmet so you can take on the mountain with ease. Features: 6 super cool vents with mesh covers, Stack vent, Short shell, Visor/brim, Compatible with all after market TuneUps systems. Certifications: CE EN 1077, Warranty: Lifetime, Gender: Mens, Special Features: Stack Vent, Special Features: Fit Kit Pad System, Race: No, Category: Half Shell, Audio: Audio Compatible, Brim/Visor: No, Ventilation: Fixed, Custom Fit Adjustment: No, Year Round Capable: No, Shell Construction: Hard Shell, Model Year: 2011, Product ID: 195611 - $34.95


text:
Member since September 19, 2009
Web Site
Right now, I'm reading:
My Sister's Keeper
My favorite story of all time is:
How my parents met.
In bed I like to read:
Besides SMITH, I read stories at:
NPR - This I Believe
If you were to throw up your hands in exasperation and yell "it's the story of my life," what would you be talking about?
Forgiveness, love and grace.
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text:
Masseria Torre Maizza, a converted farmhouse hotel with pool and private beach in Puglia, is offering a five-night stay for a family of four for £815 (kids under 12 go free), on a B&B basis. The offer is valid September 29-November 31. 0039 080 4827838, masseriatorremaizza.com. Alitalia (alitalia.com), British Airways (ba.com) and BMI (flybymi.com) fly London-Bari. Ryanair (ryanair.com) flies to Bari or Brindisi .
Ben Wyvis Hotel in Strathpeffer, near Inverness, has a three-night family break with activities including quad biking or horse riding. From £189pp for adults and £104.50pp for children under 14, half board, plus activities. 0870 9506264, crerarhotels.
At Moulin de Maitre Cornille, an 18th-century windmill near Avignon, activities include mountain biking, horseriding, fishing, canoeing and tennis. £370 per week (sleeps 5-7). Available Sept 23-Oct 21 and Nov 4 onwards. homelidays.com.
A four-bedroom villa with its own beach and pool is on offer through Owners' Syndicate, for £1,365 (reduced from £2,600) for a two-week stay during September and October. Sleeps 8. 020-7801 9801, ownerssyndicate.com.
The Adventure Company (adventurecompany.com, 0845 4505311) has launched its 2007/8 programme with 12 new trips, including Madagascar and Ireland and winter activity breaks. The Active Slovenia Teenage Adventure involves hiking, biking, climbing and staying in river and mountain camps, from £629pp. All trips include flights, transport, some meals, accommodation and the services of a group leader. The minimum age is five but there are some specialist infant trips for children as young as one.


text:
the new futuristic way of describing something in a positive connotation, popularized by rapper Max B
What you talking about, I'm the wave man, the silver surfer, I'm wavy B
Anybody that know me know I'm the waviest
Anybody that know me know I'm the waviest
by its moi February 21, 2008
adj.) To be fly, impressively dressed, attention seeking through the way you're clothed. To wear nice attire.
by Phat$ Dolla$ May 22, 2008
the word everyone started using when they hopped on Max B's dick... roughly translates to mean somethin is real nice, or somethings good... basically it just has an overall positive connotation
1. yo dat car is wavy.
2. i'm feelin real wavy right now.
3. i'm ridin max b dick so hard yo, shit is wavy!
2. i'm feelin real wavy right now.
3. i'm ridin max b dick so hard yo, shit is wavy!
by Eddie J. December 22, 2008
Cleveland Steamer Plush
The vengeful act of crapping on a lover's chest while they sleep.Buy the plush
by Wavy April 10, 2012
by drybutta September 05, 2010
Man, that rollercoaster was wavy!
by amar_bellamente September 28, 2015
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
A female who has it all (beautiful face, nice top, round bottom and trill personality).
*Term used by jiggy niggas.
*Term used by jiggy niggas.


text:
FIFA Official App
By FIFA
Open iTunes to buy and download apps.
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Download the Official FIFA App to keep right up to date with live scores from across the globe, breaking news and photos, and exclusive videos, interviews and features from FIFA.com.
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- Developer: Federation Internationale de Football Association
Compatibility: Requires iOS 7.0 or later. Compatible with iPhone, iPad and iPod touch.


text:
Case Conclusion Date: 05.15.2008
Practice Area: Insurance
Outcome: Settlement ~$120,000.00
Description: On October 1, 2007, Mrs. Glass's high-end vehicle was stolen from her home. Mrs. Glass immediately contacted the police department and notified her insurance company, Progressive Insurance Company, about the theft. Progressive Insurance accepted the claim and requested pay off figures from Mrs. Glass's Credit Union three days following the theft. Then, without any explanation whatsoever to Mrs. Glass, Progressive Insurance Company turned Mrs. Glass's claim over to their special investigation unit and forwarded Mrs. Glass a Reservation of Rights letter. The letter provided no explanation other than that Progressive was investigating the incident. Progressive Insurance Company did not respond to Mrs. Glass's requests to Progressive Insurance Company for an explanation as to why the claim had been transferred to the special investigation unit. Mrs. Glass inquiry as to whether or not Progressive had simply turned this claim over to the special investigations unit to delay payment of this high-end loss also did not receive a response. Likewise, Progressive Insurance Company did not respond to Mrs. Glass's request for prompt payment of the claim. Progressive's special investigator, Ted Cimino, contacted Mrs. Glass's neighbors and showed up at Mrs. Glass's home unannounced. Mr. Cimino described this behavior as "typical special investigations unit cold call tactics." Progressive's investigator even went so far as to attempt to question Mrs. Glass's business partner at his home. Again, Mr. Cimino showed up unannounced. Progressive required Mrs. Glass to turn over private phone and financial records, including cell phone records, bank records, and income tax returns. Progressive subjected Mrs. Glass to an examination under oath. This is a process in which Progressive Insurance Company's attorney questions the insured in front of a court reporter and in the presence of the special investigation unit investigator. Progressive refused to allow Mrs. Glass to have anyone, other than her attorney, present. Progressive also refused to allow the examination under oath to be video recorded. These tactics, and more, were extremely upsetting, embarassing and humiliating for Mrs. Glass. Mrs. Glass felt compelled to obtain the assistance of an attorney because her insurance carrier, Progressive Insurance Company, was not treating her fairly and indeed was treating her as a criminal. On May 15, 2008, this matter resolved for $120,261.29 without the necessity of filing a lawsuit.


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Sealing the hole
"So let me get this straight." The Security guard to the space station began. "You're saying that you're the one who made the hole in the sky, and you flew into a world inside a computer?"
"That is correct." I nodded, as did Richard and the professor.
"And now monsters, from the internet, are invading this world."
"And you think you can stop all of it... but first you need to use NASA... to take a spaceship to the hole, and repair it... with staples and a blanket?!?"
"Pretty much yeah. You guys have anything to add?" The professor walked forward excitedly.
"Yes! I was the reason he broke the sky, because a sceince experiment of mine mixed his DNA with that of a peregrine falcon, so now he can change to a falcon and humand mix on command. Oh! And Richard here can turn into a badger and human mix! Isn't that right Richard?" Richard nods vigorously.
"It was a very nasty experience."
"Oh, also." I spoke up again. "Because while I was in the internet I fought an octopus monster, some of my bird features are made of titanium."
The security guard looked at me, then the professor, then Richard, and then he started laughing. I quickly realized that explaining the situation probably wasn't the best thing to do. So I moved to plan B.
"I can see that you doubt us, that is understandable, so me and Richard will demonstrate our powers." Richard looked at me in a way that made me think he didn't like the idea. But I don't really care about Richard yet, so I started changing.
I sprouted my enormous titanium wings out of my arms, my fingers once again began hooks of steel. My mouth formed a titanium beak, and my feet, which haven't worn shoes in a very long time, took the form of three pronged claws. Richard sighed, and then his change also begun. I watched as his head and body grew furry and his teeth grew sharped. Then he grew paws, claws, and stripes. He was a bit shoter than me now, but still looked awesome. I tapped on the security guard, who was still laughing.
"Bahaha! I can't believe you guys expected to..." Yeah, that's when he saw us. "AHHH! MOMMY!!!" He tried to run into the station, but I stuck my claw into his shirt and lifted him. Then I looked at the professor and nodded.
"Right then, you will escort us to your finest rocket?"
And then he did.
It was a fairly nice rocket. Good engine, good shape, a bit small, but it will suffice. We were just starting to load the ship when another man walked in. Unlike the security guard, he didn't seem to fear us. And why would he? He had a shotgun.
"Freeze! Put, the security guard, down!" Bad choice of words. I threw the security guard at the man, and then took out a few of my titantium feathers and dropped them to the ground. Then I changed back to my normal self. When the men got back up, I picked up the feathers, and got into ready position.
"You are under arrest!" The security guard tapped on the other mans shoulder.
"Um, sir, I don't think you want to provoke them!"
"Get ahold of yourself! We are security officer, we are feared! We do not fear!" I threw a feather at the officer's hand and forced him to drop the shotgun. I threw one more at his knee and he collapsed to the floor. The security guard panicked and ran away. I walked up to the officer, picked up the shotgun, and shoved it in his face.
"I don't want any trouble. I'm just using the ship to fix the hole in the sky."
"You're... you're good guys!?"
"Dur, notice how you're still alive."
"But wait!" He struggled onto his knees, painfully. "If you can turn into a bird, why can't you fix the hole without the ship?"
"Have you ever tried to put a blanket in the sky? It's very inconvenient to do alone!"
"Well no! You can't have the ship, I forbid it!" I hit him in the face with the gun and then threw it at him. He was completely unconscious. Then I took the last of my feathers, and stuck him to the floor.
"Okay, let's go."
"B-b-but what about him?" The professor was still staring at the officer. Richard turned back into a human.
"Yeah, is he okay?"
"Oh yeah, just stupid." Richard and I got into the ship, the professor still had his reservations.
"I'm not so sure about this Justin... What if we don't make it?"
"Let me ask you something Goofball. Would you rather die slowly from monsters, or have a 50/50 chance at survival in a rocket ship?" And with that, he joined us.
I have no idea how to use a spaceship, so I just started pressing random buttons. I managed to put my seat backwards, turn on the seat warmer, and pour coffee on the professor. Then Richard took a look at the controls.
"Why didn't you push the button that is clearly labelled 'GO'?"
"I thought that would've been too obvious." I pushed the go button and the ship took off. We were well on our way to shutting the hole in the sky, and not a moment too soon.
Yeah, turns out Dr. Octogonapus doesn't like being viciously destroyed.


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We welcome our first guest post from our dear friend Xuân currently living in London. She showed us a sunny picture of her antidote to the gloomy British autumn weather and immediately made us both crave a piping hot bowl of bún riêu. We also love all the improvisations Xuân deployed to create a diasporic variant of a Vietnamese classic dish.
In case you are wondering, this blog entry is not by Oanh and Dang, our dear creative chefs. This is Xuan, Oanh & Dang's long time friend and a big fan of their creative Rauom's cooking fantasies.
What am I doing here?
I was invited by Oanh to be their guest blogger this week sharing my story of making bún riêu. What an honour! Thank you, Oanh. I'm trying my best. Ahem…
Where do I start?
Ah yes, from Rauom blog's search box.
Lately, I often find myself time and again going first to Rauom blog's search box to find inspiration and recipes before I head out my cooking adventures in London.
But the recipe for bún riêu was not available yet and my cravings for bún riêu were so much to bear, given London's ghostly, cold weather and the Brits' reputation for food. So, I decided to make bún riêu from 3 main things that I can gather:
- Crystal clear broth, made easy
- Salmon bones from local fishmonger
- Frozen minced crab-meat (thịt, mai cua xay nhuyễn, đông lạnh ở siêu thị Việt Nam) found in Vietnamese supermarkets
Below are all the hurdles and joy of making it.
Making the broth
I just followed closely Oanh's instructions on how to make clear broth from kombu. The experiment was successful. The broth was clear, as promised. But I do miss the fatty layer on top of the broth, as when you make broth from ox-tail bones and pork bones. That was when the 'Eureka' moment came it. Why don't I 'recycle' the salmon bones from a local fishmonger near my place? I saw how they wasted the salmon by just throwing away all these meat and bones.
What if it wouldn't work? Nah, it's OK. After all, I am just experimenting and exploring the possibilities.
Making the "riêu" (crab meat "fluff")
So the broth was ready. Now, for the riêu cua, you need to drain the water from the frozen minced crab meat first (thịt, mai cua xay nhuyễn đông lạnh).
I also did a search on Google for various recipes and found this one on making riêu cua helpful:
When the broth is boiling, just slide the minced riêu cua into it. Eventually, it will float up as a sign of being cooked already. It was quite thrilling for me to watch the process as I've never done it myself. I was afraid that all the riêu would just sink to the bottom.
But luckily, to my relief, they floated. Onto the next part then.
Making other accessories
Essential accessories to riêu cua include: tomato, fried tofu cubes, tamarind, mắm tôm (shrimp paste) and of course loads of herbs such as rau quế (basil), bắp chuối (banana flowers), rau muống chẻ (split water spinach stems), rau kinh giới (Vietnamese balm). I couldn't find these herbs in Chinatown after coming out late from work. So, voila, I just used dills. So please do not follow this and please excuse that part.
To process 5 tomatoes, you need 2 teaspoons of oil and 1 teaspoon of annatto seeds (hạt điều đỏ). Just heat the oil, add the annatto seeds until the red colour comes all out and then remove all these seeds. Add the sliced tomatoes in, stir fry, then add a little bit of salt, sugar, and hạt nêm Knorr (bouillon cubes). Don't overcook this, as the tomatoes will get too soft when they go into the broth afterward. Not nice looking. You already have the solid, healthy broth. You don't want to ruin that look with mushy tomatoes.
Final touch-ups
For me, this is the most difficult part: the part of aiming, finalising every taste, every ingredient in order to make it there: the bún riêu flavour. There are points when I had to close my eyes, trying to reminisce the rich flavours of bún riêu on a cold rainy night in Hanoi or Saigon so that I can aim for that taste while cooking here in London.
And so, into my bún riêu pot went:
– One small bowl of tamarind liquid filtered from tamarind cube mixed with warm water (Một chén nước me lọc)
– 3 teaspoons of shrimp paste
– 3 teaspoons of fish sauce
– 1 teaspoon of sugar (C'mon. I'm from the South).
Actually, to be honest with you, I can't remember now the precise measurements. After tasting for a while, slowly I arrived to that point of 'this is it'. Happy inside, I shared the image of bún riêu with Oanh.
Sharing beyond cooking
From my little experience, the key to good cooking is good eating experiences. I am forever grateful for my roots in Vietnam where I grew up in a family filled with aunts who can cook delicious đám giỗ (memorial feasts) for a whole village. My travelling life in Vietnam also brought me to countless bún riêu street vendors. These little moments of indulgence have eternally shaped my taste. No matter where I am, be it London or Copenhagen, I will somehow slowly and amazingly retrieve it.
Here I share with you my first attempt. I hope it'll get better with time.


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Do you want to get fertility treatments in Hawaii? If you're married, there's a good chance that the treatments will be covered by insurance.
But if you're not married, you're probably out of luck.
Insurance companies in Hawaii are only required to cover fertility treatment for married women, not for their single counterparts. And treatments must use sperm from the patient's spouse.
Piilani Smith, a Native Hawaiian hula practitioner who also happens to be single, sought to change that law, saying it discriminates against all varieties of unmarried women including Native Hawaiians, who historically did not observe marriage in the traditional Western sense.
"In Hawaiian culture, there's nothing sacred about the institution of marriage," Smith said. "It doesn't exist. What exists is the respect for family, and ultimately ancestral genealogy."
But a push in the Legislature to expand coverage for fertility treatments to unmarried women died Thursday with the end of the session.
Hawaii is one of 15 states that have insurance mandates for fertility treatments. And the state is not alone in excluding single women from the benefit. Maryland has a similar law, according to Resolve, an organization that tracks fertility policies.
"The goal here is to not cover people," said Barbara Collura, president and CEO of Resolve. "The goal here is to exclude as many people as possible, so that your actual coverage is pretty minimal.
Smith helped craft legislation during the 2014 session that sought to expand the classes of women that are left out of the insurance mandate. Two bills were introduced that sought to expand the mandate, but both proposals died. Then she pushed for a resolution that asked the state auditor to study the possibility of expanding the insurance mandate, but that also failed.
"If it can't be offered to everybody in a non-discriminatory manner, than repeal it," Smith said. "Because it's a bad law, and it's the wrong message to be sending to families."


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- Corporate investment in interactive marketing programs will exceed $76B in the US alone by 2016, with social media marketing program spending growing to 26% of all advertising spend, according to Forrester Research;
- Advertising is, and will continue to be, the largest contributor to overall social media revenue and is projected to have totaled $8.8 billion in 2012, according to Gartner.
NEW YORK, April 16, 2013 /PRNewswire/ -- SocialFlow, the leading social media marketing company, today announced a $10 million round in Series B funding. Fairhaven Capital led the round and was joined by existing investors SoftBank Capital, RRE Ventures, AOL Ventures and Betaworks, as well as new investors kbs+ Ventures and Rand Capital Corporation (NASDAQ:RAND). SocialFlow will use these funds to accelerate its range and reach, expand its product portfolio and further develop its partner base as the market for intelligent social network engagement and analytics platforms expands. (Logo: http://photos.prnewswire.com/prnh/20130319/CL79876LOGO ) This market expansion is being driven by the need of brands and publishers to identify optimal points of engagement - in real-time and with context relevance - among the millions of conversations being held every minute within the social networks. According to recent analyst reports:


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1979: Memories from David Sadler
I attended Trident Academy from 1974 until graduation in 1979, and worked there from 1985 until 1990.
As a student I would have to say that the one-on-one attention during language development made the most dramatic impact on my being able to attain a bachelors degree and then a masters degree. Those little tricks that Mrs. Dye taught me have served me well throughout the years. I would also have to say that the athletic program was a major player in my development. Being on the soccer field or the basketball court playing other schools allowed so many of us to feel like we were a part of something special. The combination of academics and athletics cannot be overstated.
From the teacher/coach perspective I would have to say it was seeing that sparkle in the students' eyes when they learned how to navigate around a learning roadblock and figured out that they were able to do anything if they applied and believed in themselves. Again the athletics allowed students, who maybe would not have normally played organized sports, an opportunity to be a part of a team and find out that they can compete if they put in the effort and practice time.
Trident was, and still is, a very important part of my life. Without the help that I received from staff and students alike, I would not be the person that I am today!
Thank you Trident!
David Sadler
Class of 1979


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Chelsea face 'bogey team' Liverpool
After four straight league defeats against the Anfield club, anxiety mounts despite need to keep pressure on leaders Manchester United
Roberto Di Matteo admits Liverpool have become Chelsea's "bogey team" ahead of the visit of Brendan Rodgers' side to Stamford Bridge today.
The importance of maintaining the pressure on Premier League leaders Manchester United will provide a more powerful incentive to the Blues, but Di Matteo's side are also anxious to end a run of four straight league defeats against the Anfield club.
Chelsea savoured success by beating Liverpool in last season's FA Cup final, but with the current title race threatening to be a tight, three-way battle among the Blues, United and Manchester City, league points are now the immediate priority.
Manager Di Matteo said: "They are our bogey team. They seem always to play exceptionally well against us and get results. It is always difficult and very difficult to beat them. It hasn't happened too often in the last three years. We have to be aware of that and be very focused and try to play a very good game.
"First of all, they have very good players and they seem to have an exceptional game, one of their best of the season, whenever they play us.
"They always find to play us in a moment when we are not at our best. Sunday, we are in good spirits, full of confidence and the team is playing well. Hopefully it will be a different story."
Di Matteo's desire to reverse the recent trend will be shared by Fernando Torres, who has yet to score against his former club since his £50 million (HK$618 million) move in January 2011. Torres' performances have improved this season and he scored in the midweek Champions League victory over Shakhtar Donetsk, but the Spain international has yet to reproduce the form he showed at Anfield.
"Sometimes playing against your old team gives extra motivation, sometimes it inhibits you," Di Matteo said. "It depends on his frame of mind.
"I am happy with his contribution. It is not about him repaying my faith. It's about him performing for the club. I hope every player feels they have the confidence of the manager."
Liverpool defender Martin Skrtel shares the view that Torres, who has scored seven goals this season, remains a potent force. "Even if he isn't scoring goals at the moment, he is still one of the best strikers in the world and still dangerous," Skrtel said. "I haven't seen Chelsea play too many times this season but from what I've heard, his performances are better than last season."
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PortCityDaily.com is your source for free news and information in the Wilmington area.
Brunswick County education officials have signed off on funding for a project to refurbish a Southport-area athletic field tainted by coal ash.
Nearly two years after the material was found beneath the South Brunswick Middle School baseball field surface, the board of education recently allotted approximately $290,000 to rehabilitate the field. Another $180,000 will be used to remove the pile of coal ash offsite to a landfill approved to contain the material, Sue Rutledge, director of operations for the district, said.
The coal ash was identified in late 2013, several months into a project to renovate the existing field. According to district operations staff, a county engineer overseeing the original construction of the field in 1992 used coal ash–a free, readily available material from nearby the nearby Cogentrix plant–to fill the field.
Unaware the coal ash had been used–and noticing the soil looked unusual–the district ran initial tests that identified the presence of heavy metals, contacted the NC Department of Environment and Natural Resources (DENR) and voluntarily closed the field as a safety precaution.
Coal ash, the by-product from burning coal, contains, among other heavy metals, arsenic, lead and selenium.
"The state did not close the field; the school district decided voluntarily to do that," Cathy Akroyd, public information officer for DENR, said in a previous interview. "We have done sampling, and it has shown that the field is safe for school sports."
Follow-up testing last year revealed higher-than-normal levels of arsenic – found naturally in small amounts in this region's soil – but additional sampling of the groundwater since that time has come up without heavy traces of the chemical element.
Rutledge said DENR is currently reviewing Brunswick County Schools' draft remediation plan.
"We expect to get that back any day, and based on their comments we will either talk with them and make changes to it or we won't have to make any changes to it," she noted.
Should the latter occur, Rutledge added, the approved plan would then be presented by DENR for an online 30-day public comment period.
Acknowledging the back and forth with DENR "just takes time," Rutledge is hopeful that, pending response from the public, the district can soon begin bidding the project work, which includes placing an overlay of soil and grass on the field and installing an irrigation system.
Should everything move along according to schedule, Rutledge said the field should be reopened in the fall. And when student athletes do finally take the field again, she said they will notice some major improvements.
"That field didn't have very good grass and playing conditions anyway," she said. "And it did not have irrigation and was in really poor condition. Coal ash or no coal ash, this will be a nice field once this work is done."
The estimated $470,000 price tag for the work is being paid for through the district's existing fund balance. Although a host of upgrades to school athletic facilities is included in a proposed $153 million bond referendum the district hopes to include on this November's ballot, Rutledge said the nature of the coal ash mitigation requires that field be renovated sooner rather than later.
Since the field's closure, South Brunswick Middle school students have used alternate sites for practice and play, including adjacent South Brunswick High School and nearby Smithfield Park.
Hilary Snow is a reporter at Port City Daily. Reach her at firstname.lastname@example.com.


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Pope Francis will immerse himself in some of Asia's most fervent Catholicism during a trip to the Philippines and Sri Lanka starting Tuesday, with millions of devotees set to turn out.
The Argentinian pontiff with a man-of-the-people reputation could attract one of the biggest gatherings ever for a pope during an open-air mass in the Philippine capital of Manila.
The January 18 event may draw up to six million people, offering a pulsating example of Asia's status as a dynamic growth region for the Catholic Church -- but also creating a security nightmare.
The pope's trip, which begins in Sri Lanka, comes just five months after he visited South Korea, signalling the huge importance the Vatican places on Asia and its potential for more followers.
"This second trip to Asia... is a message in itself for this great continent. It is necessary to have the pope return to this important part of the world," Vatican spokesman Father Federico Lombardi said as the 78-year-old pontiff prepared for the week-long visit.
In Sri Lanka, the pope will preach reconciliation as the majority Buddhist nation of 20 million people continues to endure ethnic conflict following the end in 2009 of nearly four decades of civil war that pitted separatist Tamils against Sinhalese.
Religious violence has continued since then, with attacks on mosques and churches by nationalist Buddhist groups who say minorities have undue influence on the island.
But he will land in Sri Lanka just days after Maithripala Sirisena scored a stunning peaceful election victory over veteran strongman Mahinda Rajapakse, a result that offers hope for future peace prospects.
During his two-night stay, the pope will visit a church that sheltered refugees from across the religious and ethnic divide during the civil war, and which has a 450-year-old statue of the Virgin Mary.
The centrepiece of the visit will be a public mass on the sea front in the capital of Colombo, which is expected to attract one million Catholics and followers of other religions.
Sri Lanka has a sizeable Catholic minority of about 1.5 million -- but it is when Francis reaches the Philippines on Thursday that he can expect to feel the most vibrant and colourful forces of the region's Catholic faith.


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