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Originally posted on NESN.com | Last updated 12/5/12
The Red Sox' shake-up may not be done just yet, even after a couple of high-profile signings in the first two days of baseball's winter meetings. The Sox have been among baseball's busiest teams this offseason, and they've kicked it up a notch since arriving in Nashville for this year's winter meetings. In the last month, they added catching help with David Ross. They added outfield depth with Jonny Gomes. All of that led to the reported signings of first baseman Mike Napoli and outfielder Shane Victorino at the meetings, addressing two more glaring needs. The Sox may not be done, though, and it could be through trade that they continue to retool a roster that won 69 games last season and finished last place in the American League East. CBSSports.com's Jon Heyman reports that the Sox are listening to offers on "just about everyone" right now, including even starting pitcher Jon Lester and center fielder Jacoby Ellsbury. #redsox seem willing to talk about just about anyone, even lester and ellsbury. very active here #obvs— Jon Heyman (@JonHeymanCBS) December 05, 2012 This, of course, means any sort of deal is far from imminent. The tweet is purposely vague, and it's also worth nothing that there aren't even any rumored deals on the table. If true, however, it does speak to how open the Sox sound to doing just about anything this offseason. Ellsbury rumors began to percolate on Tuesday night when the signing of Victorino became reported. The Boston Globe reported that the Red Sox were open to trading Ellsbury, especially if they were able to re-sign Cody Ross. They would presumably then move Victorino to center, making Ellsbury expendable. He has one year left on his contract, and he's expected to be looking for a monster deal next offseason — if he isn't signed to a contract extension. Lester, on the other hand, is a little bit more peculiar. Boston has a clear need for starting pitching, so dealing Lester may not make much sense. Unless, of course, there was some sort of blockbuster deal on the table. However, there have yet to be any reports — aside from this one — that have mentioned Lester in anything, so it's probably safe to assume that any sort of deal may be down the road.
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Hi everyone…. Yeah… it's been forever... I know! I'm so sorry about that! All I can say is that life has been hectic! But I'm glad this craziness is almost over! Just 2 more weeks and I'll have my long waited vacation! YAY!
Well… for those who stillhaven't given up one me, I better let you get to the story now… hope you enjoy it! And don't forget to let me know what you think! And since we're almost there anyways,Happy Easter :)
A BROTHER'S LOVE – Chapter 5
He didn't really know how long he had been ridding, but the Hithaeglir was already showing its shape in the distance. He knew he would have to stop soon, for Thalion would be in need of the rest, and so would he. But if his heart was to take control at that moment, rest would probably be skipped, and they would stop only upon reaching the Dark Mountains… but he knew such a thing to be folly. Strength and sharpness of senses were needed in this quest, and now more than ever since he was alone, having none but himself to rely on.
Looking up at the Misty Mountains, growing ever closer, he prayed that this journey would be an uneventful one. He already had too much on his mind, and he felt as if time was not on his side... and the last thing he needed right now was wasting his time or having his progress hindered by having to deal with orcs, spiders, or any of those foul creatures of the Dark Lord.
Reaching the shores of the last brace of the Bruinen, Legolas pulled Thalion to a stop, swiftly dismounting the horse.
"Thank you, my friend" he whispered at the stallion's ear, wanting the animal to know how much he appreciated his efforts to keep the pace that he was setting.
Taking some steps back, and letting him free to drink and graze at his own will, Legolas walked to a nearby tree to try and get some rest of his own. With all that had happened during the previous day, from early morning when he found that cursed piece of paper until now, he hadn't really had any time to rest... even the supposedly leisure afternoon and the delightful dinner were all but that, for his mind was frantic with worry for Gloreloth's fate.
He sat down, letting his head rest on the strong trunk, focusing on the tree's song, which gave him some small measure of comfort. But his mind kept going back to that dreadful note... and further back to the first note that he had gotten all those years ago... so much like that one. It was like he was reliving that same nightmare all over again… but this was not nightmare… it was real… painfully real.
Grief threatened to grip at his heart, but he pushed it back, turning his thoughts back to those filthy wargs that held one so dear to him.
"They will pay for it." Legolas hissed, anger taking over him. "They will pay for it dearly".
He looked around, searching for Thalion, and saw him not ten feet away.
He sighed… feeling desperately the need to move on. More than anything he wanted to keep going… to cover at full speed the remaining miles that separated him from his goal... but he was a warrior, and as such he wasn't about to give in to his feelings and endanger his friend's life by exhausting him to death.
Closing his eyes, he again tried to get some rest himself, knowing all too well that rest was the last thing he would find.
A few moments passed with him in this same, when Legolas felt a soft push on his shoulder, and upon opening his eyes, he found Thalion nudging him to get up.
He smiled at his four-legged friend, knowing that the horse was well aware of his distress.
"I will never be able to thank you enough for this, mellon nîn", he said, feeling incredibly touched by his horse's actions.
And that was how, not even an hour after they had stopped, elf and horse found themselves closing the still remaining distance to the mountains.
The elves from Rivendell and the human that were riding together were a quiet lot. Not a word was uttered or any comments made.
Elrond was riding up front, leading the way, followed closely by his three sons. He had hoped that maybe, they would find Legolas before he made it to the Misty Mountains, but that was his hope talking. He knew for a fact that they would never be able to reach him... at least not until the younger elf got to Mirkwood. The prince was a fast rider, and his horse, strong… and it was clear that the pair would be pushing themselves to the limit.
But he also knew how Legolas thought. The young archer would never try crossing the Hithaeglir without any kind of rest. And he prayed with all his heart that their stop would give them enough time to reach the duo, even though his mind told him otherwise.
Looking up, he realized how close they were to the mountains, and decided this was a good moment and place to stop and give the group a chance to rest.
Pulling his horse to a halt, Elrond called out loud enough to be heard by every member of the group.
"This is where we'll rest. The horses need water and food... just as all of us."
As Elrond tended to his horse, Elladan approached him quietly, eager to learn the truth behind the events of the past day, and the identity of this one that wanted their friend, for reasons he did not dare to imagine, even though he could very well guess.
"Ada?" he said in a low voice... "I cannot find peace until I know who is this one we seek... and what does he have to do with Legolas..."
Elrond looked at his son understanding the feelings that troubled the young elf's heart. He had known, since Rivendell, that these questions would come as soon as his sons had the chance to ask them.
"I wish I could give you peace, ion nîn. But I fear this is something we'll only find once this is over".
Looking past Elladan, he saw that Elrohir and Aragorn were watching them, and so he waved for the other two to come closer... he didn't want to have to retell the story. One time would be hard enough.
Elrond made for them to sit down, doing the same as soon as his three sons' attention was focused solely on him.
The elf lord sighed sadly... those were memories he would've gladly left buried. But that was not his choice to make anymore... the situation was real... and his sons wanted to know what was happening with their best friend. They had the right to know.
"The one we look for is an elf" he started slowly "a Mirkwood Elf to be precise. His name is Meneroth, and he was one of Legolas' closest friends, as was his brother, Naeroth… He was a good elf. Strong, brave... a great asset to Mirkwood's protection against the growing shadow... but that was before his brother's death…"
The older elf looked weary, as if a great burden was upon his shoulders, but kept talking nonetheless.
"They were all in the same patrol, guarding the southern borders, near the mountains, when they were ambushed by orcs. The battle was gruesome and many elves were badly injured... but Naeroth was the worst…. he died protecting the prince from one of the beast's scimitar."
"And now Meneroth blames Legolas for it" Elrohir said more as an affirmation, than a question.
Elrond just nodded.
They were all silent, as if trying to process the information which they had just been given, when Elladan raised another question.
"But why kill Lady Minuial? She was their queen. She had nothing to do with the attack… It doesn't make any sense..."
Already expecting these questionings, Elrond patiently answered.
"Soon after his brother's death, Meneroth became quiet, drew himself away from everyone in his grief. Until one day he accused Legolas for his misery, saying that if it wasn't for him Naeroth would still be alive. The discussion was heated and Meneroth tried to take Legolas' life in blind vengeance. Legolas fought him back, all the while trying to reason with him but to no avail. It was almost like Meneroth was possessed by some evil force."
Elrond shuddered at that memory… he would never forget the look on those cold eyes.
"Before the guards got to him, he managed to flee, disappearing into the forest and no one heard of him again… not until the day Legolas received a note telling him to go alone to the mountains… or the queen would pay with her life."
"In his best judgment" he continued "he took the note to Thranduil, and they prepared a rescue mission. Legolas would appear alone, as Meneroth had asked, and would secure Menuial's safety, so the army could attack. And that's how they proceeded. Upon reaching the clearing, the warriors keeping a safe distance… far enough so they wouldn't be noticed, but close enough to burst into action the moment they were needed. Legolas entered the clearing and saw his mother tied to a tree on the other end."
Elrond sighed deeply. Remembering those happenings made him feel physically sick, but still he managed to keep going. "What happened next is something that I will never forget"
The Mirkwood army approached with such stealth that one would never imagine that there were over fifty elves walking through those woods.
They soon sighted the small clearing... the cursed place where Legolas was supposed to meet with Meneroth, but he was nowhere to be found. They saw however the slumped form of their queen, tied to a tree on the opposite end of the clearing.
Legolas and Thranduil had both to fight their first urge to race to her side... but even with their hearts torn apart, they valiantly stood their ground.
By means of silent language, Maegdîn, the King's captain, made for the warriors to surround the place, ever mindful to keep a safe distance... after all, the one they sought was an elf, and one who had an inside knowledge of their ways of action, which made each warrior extra careful with their every move.
Legolas took a deep breath, reading himself to carry out his part of the plan.
As he stepped into the clearing, he was finally able to have a better look at his mother, and the sight before him was more than he could take, and he felt the sting of tears reaching his eyes.
"Naneth..." he called with a shaky breath, almost afraid of what he would hear... or rather, wouldn't. Her head was lolling to the side with her eyes closed. Many dark bruises marred her fair features, and dried trickles of blood could be seen in her neck and forehead... cruel evidences of the mistreatment she had obviously been submitted to.
"Legolas?" she asked, weakly, visibly struggling to raise her head to look into her child's eyes.
When he heard her voice and realized that she was in fact still alive, relief washed over him, making him feel lightheaded, and for that one moment he forgot about the imminent threat, focusing solely in getting Menuial out of there, and into safety.
Legolas broke into a run, wanting more than anything to hold her, and assure her that everything was going to be fine, but when she was almost at an arm's reach, he felt a tingling sensation in the back of his mind that he knew all too well and his senses peaked. Danger was near.
He quickly turned around to face whatever foe was about to appear. But as he turned, his eyes caught the glimpse of an arrow flying pass him, way out of his reach and then… a cry of pain. His mother's cry of pain.
Legolas turned around to see the damned arrow embedded in Minuial's chest. Her eyes were wide in shock, and her beautiful face contorted as pain emanated from the deep wound to the rest of her body.
"That's so you learn that when I tell you to do something, you do it… or you will face the consequences... now her blood is in your hands" Meneroth's cold and stony voice echoed from somewhere up in the trees' canopies.
But Legolas couldn't heed his words… not at that moment. With one swift strike, he cut the bonds that were keeping her, and she fell forward into his arms. Her breaths came in short gasps as he laid her carefully on the ground.
"No… stay with me… it's going to be fine… you're going to be fine" he said gently to his mom as he stroke her hair, his voice already cracking as the tears flowed down his face.
"I'm... sorry… ion-nîn… I love… you" she said between pained gasps, reaching her hand to weakly squeeze the one of her beloved son.
"No… Naneth… don't do this… please… don't leave me" he begged her, and knowing there was one out there that could still give her a chance to live, he screamed as loud as he could.
"Elrond! Help!"
But the older elf had seen what had transpired and was already rushing towards them... and as the words left the younger elf's lips, Elrond was kneeling down next to them, Thranduil close behind.
As he spoke of this, Elrond had to fight to keep his voice from faltering… those were moments that would stay carved in his memory for eternity… "I can still hear Legolas' and Thranduil's desperate pleas as I tried to save her…. begging me to help her… not to let her go. But there was nothing I could do… and she died in my arms."
Elrond closed his eyes, resting his head in his hands… even after all those years it was still too hard to talk about that horrid day.
Elladan rose from his seat, placing a hand in his father's shoulder, trying to give him some comfort, but Aragorn couldn't help but stare at the older elf in disbelief. He could hardly believe what he had just heard… so this was happening to Legolas again? That explained his friend's desperate behavior earlier and his need to keep him out of this whole matter… to watch your mom die like that… no one should have to go through that… no one! And now to have the same happening to his sister? He wished even harder that he had been able to do something... anything to ease the hurt that was certainly engulfing his friend's heart.
Elrohir broke the silence a bit reluctantly, but feeling the need to ask his father one more question.
"And what was made of Meneroth? The warriors shouldn't have killed or arrested him?"
"Yes" Elrond answered without looking up "they followed him, but he was hit by arrows, and fell down the cliffs into the Enchanted River... his body was never found, and he was presumed dead".
Seeing how hard this was on Elrond, Elladan kneeled in front of his father, bidding him to look at him.
"We will get them back Ada… both of them. No one will die but the one who was supposed to have remained that way".
Elrond eyed his son with love, extending his gaze to the other two.
"We will ion-nîn... we will... but now we should eat something." With that he got up, going over to their packs, his sons right behind him. "I don't want to stay here more than what's absolutely needed… and our time is running out".
So… Is it bad? Is it good? Let me know your thoughts on this chapter! Leave me a review:D

subset: commoncrawl


text: Cautious optimism for HIV vaccine scienceGray, Glenda E.; Michael, Nelson L.Current Opinion in HIV & AIDS: September 2013 - Volume 8 - Issue 5 - p 367–368 doi: 10.1097/01.COH.0000432529.38768.1f CHANGING ENVIRONMENT IN HIV VACCINE: Edited by Nelson L. Michael and Glenda Gray Author Information aPerinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa bMilitary HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA Correspondence to Nelson L. Michael, Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. E-mail: email@example.com Article OutlineAlthough there has been extensive clinical testing of HIV-1 vaccine candidates with almost 200 phase I trials started since 1987, only four vaccine regimens have been evaluated in phase III efficacy studies. Overcoming the challenge of viral diversity would be a huge coup in HIV-1 vaccine development. Having to contend with envelope amino acid sequence diversity amongst the nine HIV subtypes and complex intersubtype recombinant viruses as well as the error-prone replication of HIV-1 enabling escape from immune control [1] may appear to make this task almost insurmountable! These complexities have driven a maturation of the global response to HIV-1 vaccine development over the past 30 years. The formations of public private partnerships that synchronize the efforts of government agencies, funders, scientists and pharmaceutical companies to address the challenges facing HIV vaccine science represent a critical evolution [2]. These partnerships focus our efforts to ensure successful product development pathways that can end in the licensure or registration and distribution of an efficacious vaccine. Being attentive to HIV vaccine clinical trial design and analysis has also optimized efficiencies in the conduct of clinical trials and has improved the understanding and interpretation of trial outcomes [3]. The use of nonhuman primate models, utilizing different viruses or host species, has contributed substantially to vaccine development through our understanding of simian immunodeficiency virus/simian human immunodeficiency virus pathogenesis and the performance of candidate vaccines in challenge studies [4]. We have developed increasingly sophisticated tools to measure and assess potential biomarkers of protection and susceptibility, with statistical and sequence analysis methods providing opportunities to exact mechanisms of vaccine efficacy [5]. This has been especially highlighted in the RV144 study, a pivotal study in Thailand showing the first evidence for acquisition efficacy in an HIV-1 vaccine study [6]. This has driven the field exponentially forward in delineating immune responses that correlate with, and may be involved in, the mechanism of observed protection, setting the scene for the next decade of HIV-1 vaccine science. Fortunately too, the HIV vaccine field is plethoric with viral vector platforms for HIV vaccine delivery. Most advanced in development are the nonreplicating viral vectors [7] that have been studied extensively through to efficacy trials. Most notable of these is ALVAC, a canary-pox-based vaccine, studied as part of a prime–boost regimen in combination with a recombinant gp120 subunit vaccine in the RV 144 trial. ALVAC is now poised for testing further afield in high HIV incidence areas in southern Africa [1]. Further clinical research into other orthopoxvirus-based vaccines such as vaccinia (NYVAC, MVA) or fowlpox will expand our knowledge on the utility of these delivery systems. Extensive evaluation of the highly immunogenic adenovirus type 5-based vaccine platform in three proof-of-concept efficacy trials has definitively demonstrated the lack of efficacy of these candidates [8–10], making it unlikely that this vaccine delivery system will be utilized further. However, investigating other human adenovirus serotypes, such as Ad26 and Ad35, as well as nonhuman adenovirus viral vectors remain important strategies to refine our understanding of optimizing platform delivery in the nonreplicating viral vector realm. Investing in live attenuated viral vaccines, which have been shown to induce durable, multicomponent immunity thereby enabling the containment of highly contagious pathogens, make the approach of using replication-competent vector in HIV highly compelling. In particular, the advancement of live attenuated viral vectors capable of infecting mucosal surfaces and initiating replication on submucosal and lymphoid tissues for sexually acquired infections such as HIV is meritorious [11]. Advancing vaccine prototypes on the basis of vesicular stomatitis virus, vaccinia, measles and Sendai into clinical testing with optimal immunogen inserts will provide much needed information on the role of this approach in improving the magnitude and quality of immune responses. However, the critical breakthrough for HIV vaccine science will probably be in the development of envelope immunogens capable of inducing durable, broadly neutralizing antibodies at optimal levels that will be associated with protection. It has been proposed that vaccines utilizing a combination of consensus and transmitter-founder envelopes may be capable of inducing neutralizing responses that are more potent and broader than single-envelope immunogens [12]. Further development of mAbs administered as biologics in passive immunization or as inserts in viral vectors may help to expand our immunogen portfolio. The identification of correlates of HIV-1 risk from the RV144 study has catalyzed research investigating envelope structure and host–pathogen interaction aimed at guiding the immune system towards susceptible sites on the envelope as well as improving existing envelope immunogens that may translate into more durable protection. Recent results from RV144 demonstrate that protection from HIV infection can occur in the absence of neutralizing antibodies or cytotoxic T-cell responses [13]. RV144 showed that qualitative differences in vaccine-induced humoral responses against the V2 loop, associated with low levels of IgA and high levels of antibody-dependent cellular cytotoxicity, may have contributed to the protection observed. Understanding the antiviral mechanisms of protection of nonneutralizing antibodies at the mucosal surface may provide an unprecedented breadth of approaches that aid immunogen design [14]. Hopefully, our current Achilles' heel, the paucity of immunogens capable of inducing the spectrum of both broadly neutralizing and functional HIV-specific nonneutralizing antibodies, will soon be overcome. In this Current Opinion series, state-of-the-art updates in HIV vaccine science are presented covering the recent explosion of knowledge that has been gained since RV144 and the realization that we will be expanding these findings in other regions of the world using an increasingly powerful arsenal of tools based on rational immunogen design and a deeper understanding of the protective immune responses required by HIV vaccines to realize the goal of a globally effective HIV vaccine. Back to Top | Article Outline Acknowledgements None. Back to Top | Article Outline Conflicts of interest There were no funding conflicts from the authors, and no funding was used for this manuscript. G.E.G. reports funding for her research by NIH/NIAID, Gates Foundation, Department of Science and Technology (RSA), Medical Research Council (RSA), Department of Health (RSA), USAID, Novartis (flu vaccines), Merck (HPV studies). The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the Department of Defense. Back to Top | Article Outline REFERENCES1. O'Connell RJ, Kim JH, Corey L, Michael NL. Human immunodeficiency virus vaccine trials. Cold Spring Harb Perspect Med 2012; 2:a007351. Cited Here... 2. Voronin Y, Snow W. Organizing the HIV vaccine development effort. Curr Opin HIV AIDS 2013; 8:369–375. Cited Here... | View Full Text | PubMed | CrossRef 3. Moodie Z, Janes H, Huang Y. New clinical trial designs for HIV vaccine evaluation. Curr Opin HIV AIDS 2013; 8:437–442. Cited Here... | View Full Text | PubMed | CrossRef 4. McChesney MB, Miller CJ. New directions for HIV vaccine development from animal models. Curr Opin HIV AIDS 2013; 8:376–381. Cited Here... | View Full Text | PubMed | CrossRef 5. Edlefsen PT, Gilbert PB, Rolland M. Sieve analysis in HIV-1 vaccine efficacy trials. Curr Opin HIV AIDS 2013; 8:432–436. Cited Here... | View Full Text | PubMed | CrossRef 6. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. MOPH-TAVEG InvestigatorsVaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009; 361:2209–2220. Cited Here... 7. Johnson JA, Barouch DH, Baden LR. Nonreplicating vectors in HIV vaccines. Curr Opin HIV AIDS 2013; 8:412–420. Cited Here... | View Full Text | PubMed | CrossRef 8. Buchbinder SP, Mehrotra DV, Duerr A, et al. Step Study Protocol TeamEfficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008; 372:1881–1893. Cited Here... | PubMed | CrossRef 9. Gray GE, Allen M, Moodie Z, et al. HVTN 503/Phambili study teamSafety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis 2011; 11:507–515. Cited Here... 10. Cohen J. More woes for struggling HIV vaccine field. Science 2013; 340:667. Cited Here... 11. Parks CL, Picker LJ, King CR. Development of replication-competent viral vectors for HIV vaccine delivery. Curr Opin HIV AIDS 2013; 8:402–411. Cited Here... | View Full Text | PubMed | CrossRef 12. Excler J-L, Tomaras GD, Russell ND. Novel directions in HIV-1 vaccines revealed from clinical trials. Curr Opin HIV AIDS 2013; 8:421–431. Cited Here... | View Full Text | PubMed | CrossRef 13. Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 2012; 366:1275–1286. Cited Here... | View Full Text | PubMed | CrossRef 14. Forthal D, Hope TJ, Alter G. New paradigms for functional HIV-specific nonneutralizing antibodies. Curr Opin HIV AIDS 2013; 8:393–401. Cited Here... | View Full Text | PubMed | CrossRef Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.


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text:
Hi people,
My first post on here, I have just purchased a 57 plate 123d in mint condition with low mileage, its a beuatiful car but I want it remapping after driving my mates 330d before and after he had his mapped, the difference was amazing. My question is who has had theres done on here and what type of results bhp wise did you see? big difference in driving? did you use emaps as thats who i think i will be going to.
sorry if there is a lot of questions I'm just in a bit of a rush before i go out


text:
City construction boutique Shadbolt & Co is looking to expand its international network into the Middle East.
The firm, which posted a 28 per cent increase in its revenue for 2005-06, from £9.8m to £12.5m, is targeting expansion in the region to capitalise on the PPP and construction industries.
Shadbolt chair Liz Jenkins told The Lawyer that the firm may also revisit the Hong Kong office it closed in 2002. It has offices in France and associated firms in Greece and Tanzania.
"We're definitely looking to grow," Jenkins said. "But we don't have the luxury some of the larger firms have, of being able to spend and spend and not worry about making any returns for a while."
Shadbolt recently advised the Dubai Municipality on its multibillion-dollar light-rail system, which links the city with its airport.
In September the firm expanded the Paris office it opened in 1999 with a tie-up with arbitration boutique Devolve Rouche, taking name partners Jean-Louis Delvolvé and Jean Rouche.
The firm has also been active in the shipping industry through its association in Athens with Markakis & Associates, and in the projects and construction industries through FK Law Chambers in Dar es Salaam, Tanzania. Both associations have been ongoing since 2001 and Shadbolt has permanent secondees based in each.
"In time we hope to make both the Greek and Tanzanian offices formal members of our network and add others to it as well," said Jenkins.


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How dare those peons strive to get what we already have, anotherwords...
Schroeder took aim at military spending as well, using America's 12 aircraft carriers as examples of waste.
"When is the last time they were used?" she asked. "They're just steaming around showing the flag."
Ummm, to save lives in Haiti, after the Tsunami and keep the sealanes open?
Palin Power. The ability to Repel Liberals...
"you can't control who goes through them."
There's the Freudian slip again; CONTROL!!!!!
I was wondering what Patsy has been up to when she's not working in the kitchen make Jello. She sounds like the same old tired ass liberal Patsy.
She tried to chew me out one time when I made a remark near her about a female member of our security detail that was yappin away endlessly ...... I told a member of my team....doesn't she ever shut up ?
Crazy Patty went off saying .....I will never shut up .
I turned an told her I wasn't speaking to her or about her an why she felt she was talking to much when she was standing alone.
We laughed at her an she stomped off....pissed off bad.
She is nuts.
She needs to lay off the dog food.
No one knows if Sarah is planning to run for president, or any office in the future. But she is certainly very clever in allowing herself all the exposure now, long before there is any need to announce any desire for office.
Sarah is letting herself be a target and all those who want to take aim are giving their best shot. Eventually, their attempts become either ridiculous or simply ignored. But, soon all will have run out of ammunition.
Once they have said all they can say to fault her, or told all the lies they can make up, there will not be much left to use against her. The hatred can only last so long...and people's tolerance ends for stories that prove to be fabricated or simply vulgar. In two years, what more will be left to say?
Isn't Patsy the woman who would rather we tell her mother she was a prostitute than tell her the truth that she was a politician which is lower than a prostitute?
When the Democrats get their asses kicked in November, I don't want to hear any of this crap about "healing" and "now Republicans need to work together with us." Horse vomit. I want the entire progressive agenda completely destroyed.
I can't believe she is still alive, and I am appalled she is still flapping her gums. Age definitely didn't bring her wisdom.
And how many people wanted you to be president, Patricia old thing?
Another brain dead lib rises from the political grave! And what good are those aircraft carriers anyway - until all hell breaks loose and the first thing everyone wants to know is, "Where are the carriers?" If their so useless why is it that every nation with the slightest excuse for a coastline is striving to build/buy one or more? If Peppermint Patty paid any attention to anything besides her own press clippings she would have known that.
For starters, she should learn English grammar...the first person singular pronoun when it's the object of a preposition is "me."
The article doesn't say what criticisms she had of the politics in Missoula.
I guess some people just get dumber with age.
Hey Patsy once again you prove your a bitch.
Maybe when she said "people", she meant the people in Congress. I am sure when she went to Harvard Law...it was free (rolling eyes).
PS - pretty gutsy of her to take on Sarah Palin in lefty Missoula. Call me when she takes on Sharia Law or Islamic terrorists.


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Downtown Memphis Blues Screensaver includes photos of downtown Memphis, including the thriving blues-filled Beale Street, sundown on the mighty Mississippi, horse-drawn carriages,and the downtown skyline. The application includes 20 full-screen [1024x768] photos and four songs. You can enable/disable individual picture display via image previews, stretch images to full screen, position images randomly, enable/disable specific transition effects, and use your own MIDI songs.
CNet Review:
This program lets you take a virual trip to the musically rich city of Memphis, although its cheesy MIDI music and somewhat invasive installation might make some users sing the blues. Even though Downtown Memphis Blues Screensaver only lets you see eight photos before registering, they are both high quality and diverse, ranging from shots of the city's famous blues clubs to views of the mighty Mississippi River. Although the application attempts to play up the blues-music theme with some primitive MIDI tunes, they mostly just grated on our nerves. You can turn the music off or add your own soundtrack, but if you opt for the latter, you can unfortunately only add other MIDI songs. Otherwise, the program boasts a decent feature set, letting you determine the image interval, apply a number of transition effects, and remove shots you don't want. On the downside, we weren't impressed to find that the program installed extra shortcuts on our desktop without our permission. Although it has some problems, this adware-free screensaver makes a fairly nice way to quickly tour Memphis.
Note: The review & comment are referred from CNet
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text:
Firefighters urge firework safety
"We're hoping to get through the 4th without anything big," said Chief Ken Fustin of the Springfield Fire Department.
Chief Fustin and his crew are used to the celebration, but say they plan to to take extra precautions this year.
"It's extremely dry. The humidity is very low. The temperature is extremely high and the wind condition is moderately high, so it's one of those perfect storms that, if you get a brush fire going, it can go into an occupied area," he said.
That's something he doesn't want to see happen. So, now he's asking people to be extremely careful. Not just with the big fireworks, but the little ones too,
"The smoke bombs create heat. Even the sparklers kids can buy have an 1800 degree temperature on them. Some of them do. So, we just want people to use extreme caution," he said.
"One little spark can burn down your house," said Diana Albrecht. She says she won't be buying any for her grand-kids. She knows just how dangerous they can be, thanks to her dad.
"My dad's a retired firefighter and it's very important not to have little ones do fireworks because of the dry weather and dry grass," she said.
Fustin says it's probably best to leave it to the professionals. But, if you are going to buy them, he offers a few helpful tips.
"We just encourage people to be safe, have a water source, and use common sense," he said.
Local communities can place a ban on smaller fireworks if needed. Chief Fustin says that would only happen here if the weather gets worse.
Towns without fireworks displays this year include Villa Grove, Monticello and Paris.
More Stories
CHAMPAIGN, Ill. (WCIA) -- Central Illinois lost a legend Monday…
Update: 4:30 pm,…
SPRINGFIELD, Ill. (WCIA) -- Governor Bruce Rauner and his inner…


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Ninja Theory Gambles and Wins Big
Ninja Theory shows how a reboot is supposed to work. Many fans cried afoul when the announcement of a new Dante was made. Thing is, he isn't so much new as he is slightly different and one could definitely argue that he is much much cooler.
There really doesn't need to be any further discussion on that point. It does not matter one little bit that they redesigned this character and it was a bold step that paid off huge for Ninja Theory. This game was volatile from the start because either way Ninja Theory went with it, it was going to get flak from the gaming community. Either change things completely and actually deliver something memorable in the series for the first time since Devil May Cry 2, or make all of the insatiable fans happy and give them the same cookie cutter, bland experience that will quell their hunger for another few years.
Ninja Theory took the former route and I am here to tell you that they could not have done any better. It has been a great long while since character action beat em ups have been this much fun, looked this good, and told this great of a story. In fact I would venture to say that those three factors have never come together for the character action genre, and definitely have never come together in this great of a package.
Gameplay in DMC is sensational. Playing this, I finally felt like the bad ass demon Dante of yore again. The pull mechanic, where you can pull yourself to, or pull enemies toward Dante, makes combos frantic and pulling off chains of enemy kills is incredibly fluid and intuitive. The slew of weapons you can get in the two categories of basically heavy and light weapons can be switched between on the fly and one simply needs to hold down a trigger and all of the sudden you can experience a completely different combo style, even while in mid combo with your sword.
Ninja Theory uses live action motion capture for it's characters which means the faces that you see are the actual faces of actors in digital form. This, combined with the unreal engine, makes for some of the best looking character models I have ever seen. The effect also makes it easier to relate to the characters and plot points actually feel sound and have a good deal of depth, something that is unprecedented in the Devil May Cry series. That is not to say that the story is necessarily anything other than a fairly engaging and fun little narrative. The plot lacks depth and some of the cooler ideas feel like they are placed to pay off in some later game. That being said, Devil May Cry has always had abhorrent, strange, and most of the time nonsensical plot lines, this game is definitely refreshing in that regard, as it creates characters that you can actually care about even if that may only be because they are well acted and look pretty.
+ Best story for Devil May Cry ever.
+ Fast paced and incredibly fun combat
+ Beautiful, complex, and artistic environments and character models
+ Reasonable difficulty that can be seriously ramped up after one playthrough
+ Fun, imaginative and insanely epic boss battles.
- Weird lock on that poses some problems with flying foes.
- Best story in Devil May Cry ever (still isn't that great)


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Economic and Revenue Updates
The Finance Bulletin is an economic update and cash report published by the California Department of Finance, in every month but January and May. You can receive e-mail notification when the newest edition is published by subscribing to the Finance Bulletin mailing list.
View the Finance Bulletin for April 2017
You may also view a past edition from our archives:


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The Baltimore Case: A Trial of Politics, Science, and Character
€ 26,49
Lieferbar innert 2 Wochen
Januar 2000
BeschreibungKevles tells the complete story of David Baltimore, winner of a Nobel Prize for medicine in 1975 in the field of immunology, who got caught up in a legal battle over fraudulent scientific papers. Photos & line drawings.
PortraitDaniel J. Kevles, the Stanley Woodward Professor of History at Yale University, taught American history for many years at the California Institute of Technology. He has written extensively on the history of science and its relationship to American politics and society in the twentieth century. His works include The Physicists: The History of a Scientific Community in Modern America and In the Name of Eugenics: Genetics and the Uses of Human Heredity. He is a member of the American Philosophical Society and the Society of American Historians and is currently a Distinguished Lecturer of the Organization of American Historians.
Untertitel: Revised. Sprache: Englisch.
Verlag: W W NORTON & CO INC
Erscheinungsdatum: Januar 2000
Seitenanzahl: 512 Seiten
Format: kartoniert


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More than just power.
Altronix eFlow104NV is a power supply/charger that converts a 220VAC (working range 198VAC - 256VAC), 50/60Hz input into a single 24VDC output with a total of 10A. max. The unit includes an unswitched aux. output. It also offers a suite of features that includes fire alarm disconnect, overvoltage protection, and low power disconnect which prevents deep discharge of stand-by batteries.


text: While backing car into drive, caught underneath of car on large stone on passenger rear and have managed to pull down side skirt ( not a problems to put back) however there is a black protector that sits in front of the rear wheel that is broken and loose, please could anyone tell me what that part is called and how important it is. Much appreciated ladies/ gents. ( model 02 facelift e46 318se)


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This email was created by [MemberName] <[MemberEmail]> who thought you would be interested in the following Article:
"Hello UIPAB" A primer to Microsoft's User Interface Process Application Block.
CodeProject also contains hundreds of articles, free source code samples and applications to help in your day to day programming. Why not give it a try!


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Cyanide happiness
Eksploruj powiązane tematy
Defining Real Science ~~ This is accurate. When I was a research scientist, the stuff I did from day-to-day seemed pretty opaque to most people. Luckily, I'm a botanical geneticist, so I could simply say that I worked on plants. ♥
Explosm.net - Home of Cyanide and Happiness
Cyanide & Happiness (Explosm.net)
Depressing Comic Week 11 - Cyanide & Happiness (Explosm.net)
Cyanide & Happiness (Explosm.net)
Granted, this comic strip series has some raunchy stuff I don't like. But occasionally they are just too funny! Here's another funny one.
Some H and C goodness - Album on Imgur
Cyanide and Happiness, a daily webcomic
Cyanide and Happiness - Imgur


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A Ritzy Thanksgiving
Dreading Thursday because you can't cook worth a lick? The Ritz-Carlton Coconut Grove has come to the rescue. With their Turkey to Go, you can pick up an already made master- piece (plus sides) and stick a fork in the shopping and prepping madness. Among the goodies in your takeout box (beside the Tom turkey with giblet gravy, of course): sunchoke soup (hey, it's a type of artichoke); frisee salad with cranberries and spiced pecans; orange rose-mary corn stuffing; and Yukon potato country mash with truffles. Save room for the homemade pumpkin pie.
Want to fool your guests?"Put a little flour on your nose to make it look authentic,'" they say.
Order by 2 p.m Tuesday, Nov.ember 23 at 305-644-4680. Pick up at The Ritz Thanksgiving Day 10:30 a.m.-2:30 p.m. Cost: $105; feeds six to eight people.


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Wrestling Forum : WWE, TNA, Indy Wrestling, Lucha Underground, Women of Wrestling Forums (http://www.wrestlingforum.com/forumindex.php)
- Music (http://www.wrestlingforum.com/music/)
- - Official Beatbox Thread (http://www.wrestlingforum.com/music/638439-official-beatbox-thread.html)
Official Beatbox Thread
Intro: Beatboxing is a form of vocal percussion primarily involving the art of producing drum beats, rhythm, and musical sounds using one's mouth, lips, tongue, and voice.
It may also involve singing, vocal imitation of turntablism, and the simulation of horns, strings, and other musical instruments.
Beatboxing today is connected with hip-hop culture, being one of "the elements", although it is not limited to hip-hop music. The term "beatboxing" is sometimes used to refer to vocal percussion in general.
Yo yo,
I've been a beatboxing for approx 10 years now and still can't get enough. I do local live shows and recently did some festival performances over the summer with my latest project "Bedlam Beat Asylum".
My beatbox name is Bundwarr.
Anyway, enough about me.
I wanted to make this thread to discuss beatboxing, beatboxers and the culture in general.
Who are your favourites?
Who have you seen live?
I love these guys in no order: Rahzel, Killa Kela, Reeps One, ZeDe, KRNFX, Roxorloops, skiller, Hobbit.
I'm annoyed, I cant post vids at work.
Re: Official Beatbox Thread
Re: Official Beatbox Thread
I freestyle and write but mainly I just freestyle with friends I don't even want to pretend to be a "career rapper" but it's a passion of mine. I beatbox a bit but it's not my forte. I have a few very nice tunes though. I have Styles' P "Gangster and a Gentleman" down pat. Rahzel is of course that dude.
Fav of his when Wu and him cyphered.. legend-fucking-dary.
What about table beating? That was big back when. Probably still is in schools and such. I used to have a nice table top to that "Grindin'" song by Clipse.
Re: Official Beatbox Thread
That table beating never made it tho the UK really. BUT, it is cool as hell.
Love the style, thought it would be easy, but it isn't at all.
Re: Official Beatbox Thread
Beardyman best I've seen live. Saw him a few years ago at a London festival called One Taste. He had the place rocking like it was a club and it was just him and a mic.
Here's one of his shows, he adds a bit of comedy in there as well.
I think that's his official Youtube channel as well so you should be able to more of his stuff.
Re: Official Beatbox Thread
Do you have some videos of you beatboxing? You could share with us!
Edit: still at work? If so then sorry.
Re: Official Beatbox Thread
There's not much on there, there will be lots soon and i'll share as and when...
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text:
Welcome to thesoapguy - the place for wholesale soap
Here at The Soapguy we offer guarantees above and beyond your standards! Its very easy to say that this Soap Guy is not your average wholesale soap vendor. We begging by guaranteeing that any orders of seventy five dollars and above will be shipped to you at entirely no cost to you, so long as the final destination is within the United States of America. Secondly, the Soapguy guarantees that that any data and all information will never be shared with anyone, period. The Soapguy guarantees that we will never be undersold, as we offer the lowest prices available. By far the most important guarantee the Soapguy gives you is that every single soap synthesized is handmade soap that is of the finest quality you have ever tried, period, or your money back guaranteed, now questions asked. Here at the Soapguy, we are a small mom & pops business that strives to BE THE BEST! We begging with our sincerity followed by our professionalism and excelling our business with our friendliness. The Soapguy guarantees superb quality, privacy that exceeds your expectations, free shipping on all orders over $75, and ridiculous low prices!
|©2011 thesoapguy, Inc. All rights reserved. The thesoapguy mark and logo are trademarks of thesoapguy.


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This Beautiful Church Is Made Of Living Trees
A New Zealand man built the structure in his backyard.
Most Popular
New Zealander Brian Cox walked into his backyard and felt something was missing. Inspired by traveling abroad, he decided to build a church. But instead of conventional building materials, Cox chose to use trees -- living trees.
Cox built a metal frame for support before bringing in the foliage. Since he owns a gardening company called Treelocations, Cox was able to transplant already grown trees for the project.
Advertisement - Continue Reading Below
Four years later, he has a three-acre backyard church and gardens. The gardens are open for public tours or for rent as an event space. Take a tour of Cox's creation in the photos below.
h/t Bored Panda
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Need Allergy Testing in Lake Forest, CA? Simply order online 24/7 and get fast, affordable Allergy Testing at a lab near you (Find More Locations):
Why would I get Allergy Testing?
Allergy Testing measures antibodies related to allergy in the blood. People in Lake Forest, CA order Allergy Testing for general screening or to guide therapy.
How much does Allergy Testing cost?
Our Allergy Testing prices include the doctor's order that you need to get tested in Lake Forest, CA, all lab fees and taxes, and a pdf copy of your results. For current prices, please CLICK HERE.
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A pair of French opera glasses from about 1900 are signed "Lemaire, Paris," and also by the jeweler who sold them, "William H. Fink, Seattle."
Brass mounts are gold plated with a hand engraved monogram and the case is genuine abalone and mother of pearl. The gold finish is worn as shown on this elegant antique, the mechanism adjusts smoothly.
Size is 4" wide, 2 1/2" long when closed and 1 1/2" tall.
See 11 photos on Harp Gallery website that enlarge to full screen size.
USPS Shipping is $8.00 in the US.
4 other shoppers have this item in their Cart or Wish List .
Antique & Fine Furniture - Art - Antiques
Welcome to The Harp Gallery! We specialize in Vintage and Antique Furniture restored for use in Today's Home.


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A Guide to the Best Weapons and Armor (Includes "God" Armor)
View Single Post
Midnight Malice
Join Date: Jan 2008
Posts: 1,991
Gamertag: Midnight Malice
Awards Showcase
Total Awards: 2 (
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View My Profile
There goes 50 hours of my game down the toilet. You might want to highlight the part of your guide that says you can't go across to daedric from dragon. Not only does the best light armor set get no weapons, but you cant even go craft Daedric weapons without using 5 more perks what a ripoff, I am very very close to restarting because of this crap. Thats what I get for just jumping into a game I really wanted to enjoy without spoiling it too much, now I have 3 perks that ended up being completely useless.
I was already 100 before you even wrote it, so in no way do I blame you lol but something like this should be pointed out very clearly in a guide as it can cause hours of time wasted.
And as for your question earlier about best enchantments for resale, I do have to agree with you, Absorb Health for weapons is the best overall for reselling, I think I didn't have the enchantment when I first started and was using Drain Stamina and just stuck with that after I got absorb health. For Armor (from the ones I have so far which is most) Fortify Archery seems to be the general highest, with Fortify Destruction second. This is just on crap gear with a petty soul gem, but thats what you should be using for the most part.
But to defend my part about going out and trapping souls and such myself, I was leveling up conjuring anyway, and if you just run through a close dungeon you can fill 30-40 of them in like 10 minutes, and get other loot to sell, and possibly find other important enchantments to learn, all while leveling up other skills as well. But I get it, your guide is to go out and get the best armor as quick as possible, basically making yourself a god and not having the enjoyment of fighting for your life as a mammoth chases you across the plains at level 13! >.> <.< ahhh good times
Last edited by Midnight Malice; 11-20-2011 at
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This software is compatible with OSX 10.7 - OSX 10.12
About public beta versions:
What is a public beta version?
We would like to take the opportunity to start an open dialog with you in order to refine this product even further. This public beta version has been thoroughly tested by a team of beta testers. Nevertheless we believe that there is always room for improvement and at this point your input is requested.
Should I use this public beta within a production or wait for a final release?
If nothing is broke it is probably a good idea to stick with the version you already have installed on your system. On the other hand, this public beta version contains refinements and bug fixes and therefore will eventually resolve issues you have with the current release version.
When will there be a final release version?
We intend to release a final version as soon as it may be proven by your feedback that no significant new bugs have been introduced. In any case we will start to release updates on a frequent basis again in order to provide faster response to reported issues and deliver enhanced functionality.


text:
andrewl wrote:
> > Congratulations, Bob! Since my site has had secure ordering since nearly the
> > beginning,
Hi Andrew
Naylor Creek has had secure ordering for a couple of years now but the
server it was on shut down so I had to redo the cart from scratch the
second time this fall. I mean I had to find one and install it after I
did the old one earlier this fall which stayed with the old server. It
takes awhile to enter 1200-1500 plants in a cart and than almost
immediately start over.
Bob Bob Axmear 208 2nd St Ne Waukon, Ia 52172
Hostasonline http://hostasonline.com/
Gardensights Websites http://gardensights.com/
Hosta Library http://hostalibrary.org/
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
The Hunger Games: Trial by Fire
Step into the shoes of a tribute and find out if you have what it takes to win the Hunger Games (without being in any danger of being slaughtered by phsyco teenagers!).
Tell everyone how you get on by dropping us a comment.
The Hunger Games: Trial by Fire
Due to our rebellion, we are forced to live under the Capitol's mighty rule. We spend all year, working very hard for almost nothing. But on this day, once every year, the lives of two families are changed forever. Some for the better, but usually for the worse.
Tributes come in all shapes and sizes. Gigantic careers that are sure to be crowned Victor. Tiny ones from the low districts that die as soon as they get in the arena. And there's the brave one's. The one's that choose to enter hell to protect someone dear.
If I were a tribute, I'd be...


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It's no secret that Pokémon Go has captured the attention of youths across the nation. And in Plainfield it's no different. Visit Clow Stephens Park, 16650 S. Lily Cache Rd. Plainfield, August 12 from 5-7p for a free family event of catching Pokémon!
"The Plainfield Park District is exhilarated to see people visit our parks," said Director of Recreation Cheryl Crisman. The Park District encourages everyone to come out and enjoy all the parks at the Park District!
A few rules to remember at the event: 1. Be respectful to each other 2. Be responsible for yourself 3. No team discouraging. We are all playing the same game. 4. Have fun!
Bring food and drinks for yourself! - Clean up after yourself! - Park closes at dusk - Mark your status on the PPD Facebook page (Interested, Going, Not Going)!
For more information on Plainfield Park District programs and events, call (815) 436-8812, visit www.plfdparks.org, sign-up for our e-news updates, like us on Facebook, and/or follow us on Twitter.
This item was posted by a community contributor. To read more about community contributors, click here.


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For a pretty presentation, rub the rims of glasses with lemon wedges, and dip in a mixture of black pepper and coarse salt.
- 1 (46-ounce) bottle vegetable or tomato juice
- 1/2 cup fresh lemon or lime juice
- 1/4 cup liquid from jar of pickled okra or jalapeños
- 3 tablespoons Cajun seasoning blend
- 2 tablespoons Worcestershire sauce
- 2 tablespoons prepared horseradish
- 1 teaspoon celery seeds
- 1 1/2 cups plain or pepper-flavored vodka
- Garnish: Lemon wedges and pickled okra
How to Make It
Stir together ingredients in a large pitcher, and chill. Pour into tall glasses. Garnish, if desired.


text:
Definition of inflammation
Examples of inflammation in a Sentence
The drug is used to reduce inflammation.
inflammations of the throat and ears
15th Century
First Known Use of inflammation
15th century
INFLAMMATION Defined for English Language Learners
Definition of inflammation for English Language Learners
: a condition in which a part of your body becomes red, swollen, and painful
INFLAMMATION Defined for Kids
Definition of inflammation for Students
: a bodily response to injury or disease in which heat, redness, and swelling are present
Medical Dictionary
Medical Definition of inflammation
: a local response to cellular injury that is marked by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling, and often loss of function and that serves as a mechanism initiating the elimination of noxious agents and of damaged tissue
Learn More about inflammation
See words that rhyme with inflammation Spanish Central: Translation of inflammation Nglish: Translation of inflammation for Spanish speakers Britannica English: Translation of inflammation for Arabic speakers Britannica.com: Encyclopedia article about inflammation
Seen and Heard
What made you want to look up inflammation? Please tell us where you read or heard it (including the quote, if possible).


text:
Editor's notes
A deeply calming blend to help soften, smooth, relax and renew.
A beautifully sensual ritual for renewed radiance – refining natural sea salts gently sweep away dull cells while nourishing Sweet Almond Oil melts into skin to deeply hydrate. Muscle-soothing Rosemary and Bay together with Lavender help calm the mind to help leave you feeling more relaxed with smoother, glowing skin.
Suitable for: all skin types, especially those with dry rough skin, aching limbs and those who need to unwind.
Product features
About Espa
Delivery information
UK Delivery
We offer a range of UK delivery options including standard delivery, next day delivery and various weekend options. The available delivery options and prices will vary depending on the delivery location you share with us when checking out.
International Delivery
We deliver to a number of International countries, our full list of countries is available during checkout. You can change your delivery country at any time using the country selector located in the footer of our site.
Click & Collect
Our Click & Collect Service is quick and simple. Choose collect my items from one UK location during checkout and we'll email you when your order has been processed, it will be ready for collection within 3 working days.
If you are not completely satisfied with your item you may return it within 28 days for a full refund. You can return the item online using our simple service or bring it back to our flagship store in Regent St.


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Reset My Password
This will send a password reset to your email address on file. A reminder that your email address on your account must be valid and working to receive the reset request.
42re no up shift after warm up. My 1995 Grand Cherokee, 4.0L has 77,000 original miles. With the engine cold, transmission in "D" shifts normaly for a mile or so then will suddenly free wheels till R.P.M. of engine catches up with low gear. Computer has been changed and reads only code 55. Can anyone help me?


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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s11060-011-0737-8
- Cite this article as:
- Pope, W.B., Prins, R.M., Albert Thomas, M. et al. J Neurooncol (2012) 107: 197. doi:10.1007/s11060-011-0737-8
- Citations
- 1.2k Downloads
Mutations of the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are commonly found in primary brain cancers. We previously reported that a novel enzymatic activity of these mutations results in the production of the putative oncometabolite, R(−)-2-hydroxyglutarate (2-HG). Here we investigated the ability of magnetic resonance spectroscopy (MRS) to detect 2-HG production in order to non-invasively identify patients with IDH1 mutant brain tumors. Patients with intrinsic glial brain tumors (n = 27) underwent structural and spectroscopic magnetic resonance imaging prior to surgery. 2-HG levels from MRS data were quantified using LC-Model software, based upon a simulated spectrum obtained from a GAMMA library added to the existing prior knowledge database. The resected tumors were then analyzed for IDH1 mutational status by genomic DNA sequencing, Ki-67 proliferation index by immunohistochemistry, and concentrations of 2-HG and other metabolites by liquid chromatography–mass spectrometry (LC–MS). MRS detected elevated 2-HG levels in gliomas with IDH1 mutations compared to those with wild-type IDH1 (P = 0.003). The 2-HG levels measured in vivo with MRS were significantly correlated with those measured ex vivo from the corresponding tumor samples using LC–MS (r2 = 0.56; P = 0.0001). Compared with wild-type tumors, those with IDH1 mutations had elevated choline (P = 0.01) and decreased glutathione (P = 0.03) on MRS. Among the IDH1 mutated gliomas, quantitative 2-HG values were correlated with the Ki-67 proliferation index of the tumors (r2 = 0.59; P = 0.026). In conclusion, water-suppressed proton (1H) MRS provides a non-invasive measure of 2-HG in gliomas, and may serve as a potential biomarker for patients with IDH1 mutant brain tumors. In addition to 2-HG, alterations in several other metabolites measured by MRS correlate with IDH1 mutation status.


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Parts and Labor
|Type Accepted
|10 days from delivery or installation*
|Damaged, Defective, Item not as described
*The validity for products installed only by Flipkart authorized personnel shall be 10 days from installation.
If you have received a damaged or defective product or if it is not as described, you can raise a replacement request on the Website/App/Mobile site within 10 days of receiving the product.
We will help you troubleshoot any issues you may have, either through online tools, over the phone, and/or through an in-person technical visit. Only one (1) replacement will be provided in the unlikely event that the product is defective. If no defect is confirmed, the issue is not diagnosed within 10 days of delivery, a troubleshooting step cannot be performed, or if one replacement has already been provided, you will be directed to a brand service centre to resolve any subsequent issues.
Successful pick-up of the product is subject to the following conditions being met:
Know more about the Return Policy here
Procedure to Register the Product
Step 1: Please go to http://www.india.philips.com/
Step 2: Click on Support.
Step 3: Click on Register your product.
Step 4: Click on Create Account.
Step 5: Please enter the necessary details and click on Create Account Stab.
Step 6: Customer will receive an e-mail from Philips and will get a below mentioned pop up.
Step 7: Customer needs to check his/her mail box and have to click on verify and activate stab.
Step 8: Now customer need to login to My Philips via same e-mail id and password.
Step 9: Customer need to click on Register Product.
Step 10: Customer will find two options to key in the Model Number.
Step 11: Key in the model no. Click on Find now & select the particular model from the list.
Step 12: Customer to key in the product details i.e. Date of purchase, Serial number & click on Register stab.
Step 13: Confirm the customer that the product has been registered with Philips, suggest the customer to note the warranty information.
Step 14: Now customer need to check the e-mail inbox as customer will get a confirmation e-mail.


text:
|AAV Aviculture Committee
Share |
Committee Chair:
Stephen Fronefield, BS, DVM, DABVP
ABC Animal and Bird Clinic
Sugar Land, Texas
Aviculture Forum
Chat with the Aviculture Committee on our AAV Aviculture Forum.
Committee Reports:
7/29/2017 » 8/2/2017
Association of Avian Veterinarians Conference 2017
9/22/2018 » 9/27/2018
ExoticsCon 2018
Are you conducting a clinical research study related to avian medicine? Contact firstname.lastname@example.com to submit your study to be listed on our site.
Click here for current studies.


text:
Trains stopped over halt demandB Sridhar | TNN | Oct 18, 2012, 06.18 AM IST
JAMSHEDPUR: Hundreds of passengers on board several trains, including 12833 Ahmadabad-Howrah Superfast Express, had a troubling time on Wednesday owing to the blockade by residents of Manoharpur block at Ghagra between Manoharpur and Posaita railway stations in West Singhbhum district.
A group of villagers, led by local MLA Gurucharan Naik, squatted on the rail tracks demanding a halt station at Ghagra in Chakradharpur division of the South Eastern Railway. The blockade halted train movement on the main line for over three hours.
Abhinav, who was travelling on Ahmadabad Superfast Express, faced the inconvenience like hundred others. "The disturbing thing is that for over three hours not a single officer of the local division was available to tell us when the train will resume," said the 28-year-old.
Similarly, Manoj Kumar, an insurance employee travelling on Danapur-Durg South Bihar Express, said as the trains got stranded following the blockade, the stock of drinking water got over in his compartment. "I had to arrange water from a fellow passenger," said Manoj who stays at Sonari.
Although, the agitation was supposed to continue for 12 hours but following the intervention of senior railway officials, the protestors called off the agitation after about four hours.
Justifying the blockade, MLA Naik, who was initially not reluctant to vacate the tracks, said, "Our demand for a halt station at Ghagra is pending with the SER headquarters for the past several months but there's no positive response coming so far."
The Ahmadabad Superfast Express train remained stranded at Manoharpur station for about four hours and Bhubhneswar-Haridwar Utkal Express at Ghagra station for about two hours. The newly introduced Chakradharpur-Rourkela Saranda Passenger train was also stuck at Ghagra station for over three hours. South Bihar Express was stranded at Goelkera for nearly 40 minutes and Tatanagar-Itwari Passenger train at Tunia station for about 30 minutes. Movement of the goods trains was also affected because of the protest.
"Following the assurance from the authorities of looking into their demands positively within a month, the protesters vacated the track," said Chakradharpur senior divisional commercial officer A N Biswas. The rail service on the route resumed after 11am four hours after it was blocked by the locals.
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ibis Styles Osaka
Select your stay dates to check availability
ibis Styles Osaka
About the hotel
Property Location
A stay at ibis Styles Osaka places you in the heart of Osaka, walking distance from Hozenji-Yokocho Alley and Hozen ji Temple. This hotel is close to Osaka Science Museum and Osaka Castle.
Make yourself at home in one of the 343 air-conditioned rooms featuring refrigerators. Complimentary wired and wireless Internet access keeps you connected, and digital programming provides entertainment. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include phones, as well as desks and coffee/tea makers.
Grab a bite from a grocery/convenience store serving guests of ibis Styles Osaka.
Business, Other Amenities
Featured amenities include dry cleaning/laundry services and an elevator (lift). Event facilities at this hotel consist of conference space and meeting rooms.
Hotel Facilities
- Accessible bathroom
- Elevator/lift
- Smoke-free property
- Total number of rooms - 343
- Meeting rooms 5
- Grocery/convenience store
- Conference space
- Free WiFi
- Dry cleaning/laundry service
Room Facilities
- Free toiletries
- Phone
- Desk
- Private bathroom
- Shower/tub combination
- Air conditioning
- Free WiFi
- Refrigerator
- Free wired high-speed Internet
- Daily housekeeping
- Television
- Digital TV service
- Coffee/tea maker
- Hair dryer
- Premium bedding
Hotel Policy
Know Before You Go
- One child 12 years old or younger stays free when occupying the parent or guardian's room, using existing bedding.
- The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file.
Mandatory Fees and Taxes
A city tax will be collected at the property effective January 1, 2017. The city tax ranges from JPY 100-300 per person, per night based on the nightly room rate. The tax does not apply to nightly rates under JPY 10,000. Please note that further exemptions may apply. For more details, please contact the office using the information on the reservation confirmation received after booking.


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