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|Reviews for To See Konoha
| hlshinobi chapter 3 . 12/27/2012
| 00-night-eyes-00 chapter 3 . 4/12/2010
love it, cant wait to read more
| Monte0411 chapter 3 . 4/1/2010
Yay! I'm so glad you updated this story! I always thought it was great and i'm still keen to see what happens! I like the additional chapter of Naruto's little adventure. I particularly like the idea of Naruto not realising his impending ailment because he's used to being healed quickly- that's some good thinkin! anywho, looking forward to an update soon!
| PrincessAmerica101 chapter 3 . 4/1/2010
Wow...I don't even remember this story..good story anyway!
| Rena the pirate jedi wizard chapter 3 . 4/1/2010
Hehe, I remembered this story. And let me tell you, I was very confused before I read the author's note where the original first chapter use to be. There was no way this new chapter came after it. I can't wait to read some more of the story! Hm, I wonder what was in the scroll.
| terrorofthehighway chapter 3 . 4/1/2010
Uh, does that mean that you're going to be updating this regularly until it finishes? (Regularly meaning, at least once a month?)
| ImplausiblyForgetful chapter 3 . 4/1/2010
Hm... I like this fic. A lot
| MistressWinowyll chapter 1 . 3/14/2010
Really good chapter. I was a little worried that Sakura was going to die when you mentioned the 'wasn't going to make it' bit. Still, I was a little surprised that Sasuke was the one who saved Naruto, but it made sense considering that Tobi needed to attack someone in order for him to be material enough for him be attacked. Great chapter.
Your Mistress.
| hibari-mukuro chapter 2 . 1/19/2010
blind man sasuke? if yes, he sure changed.
sounds good so far. :D
| Fudo Masaru-Daichi chapter 2 . 9/30/2009
Hey,this is like,damn good.
I mean it! It's much better than most of the fics I've read lately. The story...the way your words flow...I like it. It's really good. There isn't too much description or too little. No spelling errors or such...plot is great too...
Most of the time I only read completed fics,well,99.6% of the time anyway. This time,it's different.I'm reading this fic because it's great. I'll wait for you to update,even if you take forever to.
*Repeats self* This. Is. Damn. Good.
| Ginnysaysso chapter 2 . 8/13/2009
Wish you'd finish it :)
| Dai chapter 2 . 5/28/2009
Wai! Plz continue I really love how this seems to be going! The suspense is killing me! ;-; well, anyway plz continue writing this story it is quite a good start.
| Parmelk chapter 2 . 2/20/2009
While I'm certain I know who "Kisho" is, I'm still very interested in this story. And yes, I do want an update.
| Halskr chapter 2 . 2/11/2009
After reading your other story, I had to read this one too. I hope you continue it.
| Tessa Marlene chapter 2 . 2/1/2009
I was surprised how well written this was, a bit rare for the gazillion Naruto fanfics that are here. I am interested to read more.


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Three Marshall, Gerstein & Borun LLP Partners Selected for Managing IP's IP Stars – Top 250 Women in IP
Three Marshall, Gerstein & Borun LLP partners have been selected for inclusion in the 2nd edition of Managing IP's IP Stars – Top 250 Women in IP. Pamela L. Cox, Heather R. Kissling and Li-Hsien (Lily) Rin-Laures, M.D. were chosen following extensive client case research and over 1,000 peer interviews and surveys conducted by Managing IP's editorial team. Ms. Cox, Ms. Kissling and Dr. Rin-Laures are included among only 250 leading female intellectual property attorneys from across the United States, and represent "the best of the best in their field."
Pamela L. Cox, partner and chair of IP Transactions, concentrates on counseling related to intellectual property transactions, protection and transfer for clients ranging from multinational corporations to non-profit institutions. As a patent attorney who has managed intellectual property portfolios in-house, Ms. Cox understands her clients' intellectual property and agreement needs, and remains passionately engaged until achieving their strategic objectives. Clients find her talented at unraveling complex deal structures and devising creative agreement solutions as a seamless member of their team.
Ms. Cox is named by her peers as one of The Best Lawyers in America in Biotechnology Law and was named a 2014 Life Sciences Star by LMG Life Sciences. She is an "IP Star in Managing IP's 2014 World IP Handbook and Survey. Ms. Cox is "highly recommended" for licensing and for a number of years has been named one of "The World's Leading IP Patent and Technology Licensing Lawyers" by Intellectual Asset Management. Her peers say she is a "Leading Lawyer" in Leading Lawyers Network. Ms. Cox serves as a board member for Certified Licensing Professionals, Inc. Board of Governors, is an international delegate for the Licensing Executives Society USA/Canada, chair of the Life Sciences Committee for the Licensing Executives Society International, a committee member of the Business Development Curriculum Committee for Association of University Technology Managers, and is an adjunct professor in the Master of Science Program at Northwestern University School of Law.
Heather R. Kissling, partner and chair of Biotechnology, "one of the best biotechnology practices in the country" as ranked by Chambers USA, draws from over fifteen years of experience securing biotechnology patents to develop worldwide filing and prosecution strategies that further her clients' business objectives. Using her advanced training in biotechnology, she actively collaborates with bench scientists, business development personnel, and in-house counsel to maximize protection of biotechnology innovations in a broad range of technologies including antibody and protein technology, gene therapy, viral vector and cell line technologies, recombinant DNA and expression systems, genetically modified plants and screening methods for anti-viral therapies. Her background in interference and opposition proceedings also benefits clients seeking advice with respect to competitor patent positions and third party challenges in the patent office. Clients find her to be a forward-thinking advocate that shares their commitment to realizing the maximum value from their intellectual property assets.
Ms. Kissling was selected for inclusion in the 2013 and 2014 Illinois Rising Stars® lists, featuring outstanding young attorneys in the state. She is actively involved in the biotechnology industry and committed to advancing women in the profession, having served on the Biotechnology Industry Organization, International Convention Programming Committee 2013, 2012, 2010, and 2006, the outreach committee for the Coalition of Women's Initiatives in Law Firms, and the Women In Bio – Chicago Chapter Advisory Board, Communications Committee and Programming Committee. Ms. Kissling also presents seminars on recent developments in case law, current trends at the U.S. Patent and Trademark Office, and building intellectual property assets.
Li-Hsien (Lily) Rin-Laures, M.D., a member of the Firm's Executive Committee, and leading partner in "one of the best biotechnology practices in the country" as ranked by Chambers USA, is a strategic partner in using intellectual property to achieve her clients' business goals. With over two decades of experience building and assessing patent portfolios in the biopharma industry, as well as in negotiating licenses and strategic alliances, she anticipates issues and opportunities. She brings to her practice a unique insider's perspective gained as former General Counsel of a publicly-held biotechnology company and insight acquired from managing patent portfolios for eight different approved drugs and numerous other clinical trial candidates, enabling her to be a valuable strategic partner to clients.
In recognition of her outstanding patent work in life sciences, Dr. Rin-Laures has been featured as a Life Sciences Star in LMG Life Sciences, 2012-2014. Additionally, she was named 2014 "Patent Prosecution Pharmaceutical Attorney of the Year" and was inducted into the LMG Life Sciences Hall of Fame at the 2014 LMG Life Sciences Awards. She was recognized as a 2012 Leading Law Firm Rainmaker in MCCA's Diversity & The Bar, featured as one of the 2014 "Women Worth Watching" in Profiles in Diversity Journal, selected as one of the "World's Leading Patent Practitioners" in 2013-2014 by Intellectual Asset Management Magazine (IAM), as an IP Star in Managing IP's 2013 World IP Handbook and Survey, and inducted into Law Bulletin's "40 Illinois Attorneys Under Forty to Watch" Hall of Fame. Committed to advancing women in the life sciences industry, Dr. Rin-Laures was a founder and the first Chair of Women in Bio – Chicago Chapter, and has been actively involved in numerous organizations focused on mentoring and advancing women.

subset: commoncrawl


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The City of Fargo encourages sidewalk activity to increase public use, enjoyment, and safety of our public right-of-way. With proper design and management, sidewalk activities can be a great way to encourage walking, add vitality to the street, and promote local economic development. Rules and regulations adopted in Ordinance 18-03 - Use and Care of Streets and Sidewalks, help manage sidewalk activities.There are different types of permits required by the City of Fargo prior to using the public right-of-way in the Central Business District including sidewalk entertainment, pushcarts, outdoor dining areas, and outdoor merchandise areas.
The City of Fargo established the Sidewalk Marketing Review Committee (SMRC) to review and approve or deny applications requesting the utilization of public sidewalks. The committee consists of representatives of the Police, Health, Public Works, and Planning Departments, as well as the Downtown Community Partnership.
Help make our downtown an exciting place to be! Ask about any of the Sidewalk Activities Permits by contacting the Planning and Development Department at 241-1474 (or firstname.lastname@example.com) and the Health Department at 241-1360. All applications should be submitted to the Planning Department located at 200 3rd St. N.
Sidewalk Entertainer Permit Application
Pushcart Permit Application
Outdoor Dining Area/Outdoor Merchandising Area Permit Application
Chapter 18 Ordinance
Map of the Central Business District
2017 Downtown Permit Location Map
Guide to Busking in Fargo


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Telling Joe is hardest of all. The other day he wanted to take a photo of me into school to draw a picture of what he will look like when he's an adult, "sort of tall and bald. Like you, Dad." When I explained again that he might not look like me when he grows up, he started crying. "Admit it," he said. "You're not my real dad. You're just my fake dad."
When my partner and I had trouble conceiving, I wasn't particularly anxious; after all, a woman I'd been involved with previously had got pregnant, resulting in a termination. Then the test results came back: I had no sperm. Zero. Guess it wasn't me who had got her pregnant. My partner cried on the phone to her mum, then with her best friend, forgetting to ask if I minded if the world knew I was firing blanks.
We decided to try donor insemination through assisted conception. At the hospital, we were screened, counselled, signed forms, made legal commitments; a rigorous process of opting-in. Finally we tried a course of treatment. And failed. Then tried again. Bingo!
At three months we found out we were having a boy: long before Joe popped out, we felt we already knew him. What we didn't know at this point was what we would tell him about his origins. We had told nobody so far. It seems bizarre now that we could have had any doubt. Plainly the only thing to do is to tell your child everything.
So, a few months after Joe was born, we began to tell people. My mum cried. A close friend said how sorry he was. Others told me I wasn't my son's real father and never would be. No one said, "Well done."
After a few years we wanted Joe to have a sibling. Getting him had been emotionally uplifting. The unsuccessful pursuit of another child through assisted conception was tense, wearying and demoralising. We moved on to IVF, sinking heavily into debt, but that, too, failed.
Two years later we separated. There were many reasons, but on reflection the emotional strain caused by my infertility irreparably damaged a love affair that had lasted more than 20 years.
We were not married. Legally my position appeared vulnerable - though we had agreed to share custody, when we tried to register as joint parents, the registrar refused to witness the agreement - but it was about more than just the law. We all know the statistics about dads who lose contact with their kids after they split from partners. Was I going to be another one of them? I didn't think so. But say I died tomorrow: in what way would I feature as Joe's father in his own memory or in the ongoing family account? Without blood, my ties felt tenuous.
Since splitting from Joe's mum, I have fallen in love again. My new partner has urged me to examine in more depth the issue of my infertility, and I have started to think more about the unknown man who caused my son to come into this world.
Sperm banks do screen donors for suitability. They also offer parents the chance to choose their sperm based on some characteristics. We selected a donor with similar eye and hair colour, height and build to mine. We were asked whether we wanted a "sporty" donor, or one with more of an arty, intellectual bent. We chose arty. But that was the sum total of what we knew.
To be honest, at the time, the less we knew the better, at least as far as I was concerned. Maybe it's a male thing: you couldn't deliver it up, so some other man had to do it for you. It's emasculating.
But lately I keep wondering what kind of man he was. Selfless and altruistic or an egotist eager to ensure his genetic legacy was passed on? Or maybe he just donated on a whim?
Joe will never be able to learn about, or seek out, the man from whose sperm he came. In April 2005 donor anonymity was banned in Britain; from the age of 18, all donor-conceived children now have a right to know the identity of the donor. Joe was born in 1999. The change in the law does not apply to him.
I can't help but feel sad for Joe. It makes me wish I were his biological father. I think it would be easier for him, and me.


text:
Connecting Families to Senior Living
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*Prices quoted are monthly rental charges and are provided by the communities themselves. Actual prices may differ due to one-time fees, timing and care services required. Speak with your Senior Living Advisor to learn more.
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Westbrook Senior Living is a brand new community which just opened! We are an Independent, Assisted, Transitional Memory and Secured Memory Care rental community located in Streamwood just on the border of Schaumburg near the Elgin-O'Hare expressway, shopping and restaurants. At Westbrook our goal is to help our residents retain their independence and dignity while also providing the highest levels of service and care in a state of the art building set in a comfortable and pleasant setting for all to enjoy. Choosing it live at Westbrook also means that your home will have a washer and dryer, all your meals are included and there is no charge for a 2nd person saving couples upwards of $500 a month. The dining program features the comfort of fine restaurant style dining with chef prepared meals featuring daily specials and a variety of menu choices. Dietary needs are always taken into consideration as we strive to provide our residents with healthy, satisfying options. Westbrook also provides a wide variety of activity programs to promote both physical and cognitive health as well.
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New Braunfels Herald Zeitung (Newspaper) - February 17, 1993, New Braunfels, Texas I \ i SD Wf ST Mr- * Os *'2/ y 9 , '■"> j <-% iLROPLfFll r c'ii "L O I t- YANDER no HING New Braunfels | mmmmm ' ^ * ^ ^ Tv -vz-a p ui IX 7990 . -Zefcung '; Wednesday, February 17.1993_Serving Comal County/ Home of Glyn Golf Vol. 141, No. 64 — Daily 50 cents, Sunday 75 cents Sheriff cited for war on narcotics By OAR Y P. CARROLL Harakf-Zattung The Comal County Sheriff* Department it a part of one of the top narcotic* task forces in the state, according to a letter from the director of the Texas Narcotics Control Program, Jimmy Willbom. In a letter to Sheriff Jack Bremer, Willbom said the "Alamo Area continues to rate among the best? of the 50 multi-jurisdictional task forces in Texas. Bremer said several jurisdictions within Comal County decided to join forces to be more effective in their battle against drugs. "We opted to pool our resources and train people so that when they come back to our agencies they will be valuable to us," Bremer said. "It gives us the opportunity to call on a larger number of people to respond to any kind of problem we may have." Bremer said it is difficult to devote the time and the manpower to narcotics enforcement, and what makes it worse is that rwfot now Bremer has only one officer he considers a narcotics officer. The task force is valuable because it allows for resources that otherwise would not be available, according to Bremer. Before the formation of the task force about six years ago, Bremer said it was like a game of "pick-up baseball" and whoever was around was called upon to help. But the task force allows law enforcement agencies access to specially-trained officers. This way we can call on some trained people and, of course, they have specialized equipment, such as a computer ... which is made available to a lot people who ordinarily couldn't afford it manpower-wise," Bremer said. Over the past four years, Bremer said the task force has taken more than $750,000 away from drug dealers. Bremer said the success is a result of the task force and the fact that law enforcement agencies are able to be more actively involved with narcotics control. "We know there's a drug problem out there and we know there are a lot of things that need attention," Bremer said, 'hut if I didn't have this task force to fall back on I might only be able to devote one or two people at any one time to doing that kind of work." Hie money seized from drug dealers goes right back into the law enforcement agencies and helps to train officers and purchase new equipment Willbom commended the agencies record and told Bremer, "It's agencies like yours that help in the anti-drug effort andln keeping the Texas Narcotics Control Program at the top." fr.-t> * -• wodan* toad I* an tarred motorist fotowing an automobile accident on South It (alii* to McKenna tiMlt tntertectton of Rosa lilt* Ml South IO yield the rioht oi way whan tho car ddm tty ^Kampa ortttKemp was transported where she was heated and released. Photo by John NBISD approves 25 new positions for 1993-94 year Officials hear report on effort to help TAAS scores By ROSE MARIE EASH Herald-Ze thing New Braunfels school officials approved the addition of 25 new employees last night for teaching, administrative and support positions for the 1993-94 school year. In its monthly meeting, the New Braunfels Independent School District board of trustees approved a recommended district personnel plan for the 1993-94 school year, which includes an addition of 25 employees. Thirteen will be hired as aides, secretaries or clerks, secondary and elementary school teachers. The remainder will be hired for school nutrition services, transportation, plant operation and plant maintenance. A Texas Education Agency waiver request permitting the teaching of algebra and geometry courses over a longer period of time to address the needs of some students was also approved by the board. In other business, the board heard a report on "strategies for success," which listed the various efforts made in the district to positively affect the Texas Assessment of Academic Skills test scores without specifically tutor ing just prior to the tests. At the high school level, those efforts include a better identification of English as a Second Language students, special remedial classes for those who fail exit level TAAS tests, the appointment of student leaders, summer tutorials and practice essays for the TAAS writing tests. In the middle schools, tutorials are available both before and after school, individual lesson packets are prepared for each student based on TAAS results and the district takes advantage of programs, such as HOSTS, BOOST, AT-RISK Academic, Attendance and Discipline programs and TESA Training. The HOSTS program provides reading tutoring by community volunteers. BOOST is a self-esteem building effort using district and community volunteers. AT-RISK programs identify students at risk for not graduating due to academic weaknesses, attendance problems or discipline problems. TESA training addresses strong teacher expectations and student achievement At the elementary schools, TAAS weaknesses are identified and retaught, before and after school tutorials are available and cooperative learning and student contracts are utilised. The board also adopted the recommended 1993-94 school calendar, which includes Christmas holidays December 20-31 and spring break from March 28 through April 4. Filing opens for city seats Three of five expected to run have filed Tuesday was the first official day to file to run for the three open positions on the New Braunfels City Council. As of 5 p.m. Tuesday, only three of the five candidates who previously announced their intentions had officially filed with the city secretary's office, according to city officials. Those candidates include Cheri Stratteman, Rusty Brandt and Chris Bowers. Chris Mosel, and Jan Kennedy who have announced they too will be running for city council, are expected to file today. One of the three council seats will be vacated by outgoing Mayor Clinton Brandt. Council Member Bill Arnold is up for re-election in May. The last day to file to run for city council is March 17 at 5 p.m. 'Dare to Love' program gets boost from Rotary Club By BARY P. CARROLL Herald-ZeHung Hie Comal County Child Welfare Board's "Dare to Love" program recently got a shot in the arm from the New Braunfels Downtown Rotary Club. Nile Reidel, president of the downtown Rotary Club presented Child Welfare Board President Tara Kohlenberg with a $1,500 check — enough money to sponsor four children in the program for one year. The child welfare board, a non-profit agency comprised of a 15-member board appointed by the County Commissioners Court, ie designed to educate the community about child abuse and neglect and generate money to provide for the children in custody in Comal County. The "Dare to Love" program is an outgrowth of the welfare board, according to Kohlenberg. The program was originally begun in San Antonio and was adopted by us," Kohlenberg said. "We are the first rural child welfare board to adopt it." The money received by the board for sponsorship goes toward supporting the children in the program beyond what the state provides. The state, since they are in the state's custody, is responsible for the children's welfare; beyond that, the Dare to Love program takes over. "It basically provides things that you or I take for granted," Kohlenberg said, "it's basically for esteem builders." Itdms such as clothing, sporting equipment, toiletries and other miscellaneous items that help the children fit in are the target of the program. Kohlenberg said the program's first participant, tha Police Auxiliar, sponsored a child and threw her a birthday party — something she had never experienced. They took her shopping, took her to have her hair done, they bought her presents — she had ntver had these things before," Kohlenberg said. Also covered by tha program ars medical emergencies not covered by Medicare, she said. All hinds raised by the Child Welfare Board are spent on the children. Although Kohlenberg said she is extremely grateful for the current sponsors, the child welfare board is trying to line up additional participants to sponsor the approximately 20 children in the system, and said that lucent cut backs in the budget of the Child Protective Services may put a strain on the Child Welfare Board. Thsre are currently 29 children in the Comal County system. Along with the Downtown Rotary Club and the Police Auxiliary, the child welfare board has one anonymous sponsor. For more information on how to sponsor a child, call 629-3884.Index CLASSIFIED........... ..13-16 .........S ENTERTAINMENT... EDUCATION............ .......10 RECORDS............... .........3 OBITUARIES........... ..........3 OPINIONS................ SPORTS.................. WATER WATCH______________9 WRATHER........................S StammtischBest wishes Th* New Braunfels Herald-Zoitung sends birthday wishes to Corey Doyle, Paul Bursch III and Linda Dominguez.Defensive Driving Defensive driving classes will bt held today and Thursday from 6 p.m. to IO p.m. at the New Braunfels ISD Community Education Cantar at 430 Watt Mill. Class will also ba held from 8 a.m. to 4:30 p.m. Saturday. Por information, call 620-6200.Chicken Barbecue A Chicken Barbecue plats fiind-raiser will ba held from ll a.m. to 4 p.m. March 6 to benefit the New Braunfels Mexican-American society scholarship Awd. Plates will be $3.75 and can be bought from any member or by calling 625-3439,620-4235 or 62541760.Teen Connection His Board of Directors of Teen Connection will moot at 5:30 p.m. Thursday, Fab. 18 at tbs Housing Authority of tho City'of Now Braunfels, 300 Laurel Lens to rooonsidor tho vote taken on Jan. 21, 1993 to close the alternative school at tho conclusion of tho 1992-93 school year. Oontlnuadon pagatSports Tha New Braunfels Unicorns 61 -38 victory over Clemens putt them In a three-team district tournament with Alamo Heigh* end Boerne lo decide District 28-4A't playoff representatives. AN three teams finished with an 11-2 mark In district play. Por a complete report on Mbab I ImIabimmiI seals* aaasA WW Wlwi ill Wifi j MPW Sparta. page 11. For Home Delivery rn New Braunfels rind Comal County Call 625-91-14 ;
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text:
The best Sonic games of all time
Labors of love become labors of heartbreak when great games meet a legal demise
Has HD wonderment improved your favourite games? Or just screwed them right up?
It's virtual wartime and the troops need motivation!
If you did any of these in the real-world, you'd be an asshole
From Sonic 1 to the Black Knight, which spiny avatar is best?
Why Sonic isn't a platformer and Final Fantasy isn't an RPG at all.
We welcome a former 1up editor to the cast and talk drunks, contests and stuff gamers shouldn't care about
The worst games, trends and people from an otherwise groundbreaking year
Life moves pretty fast sometimes – but videogames move faster. Here's the proof
Join us as we chat up Giant Bomb's main man, plus poke fun at Mortal Kombat and Sonic Unleashed


text:
Compass donate
by: Pedro Rainho • 7
All Android applications categories
All Android games categories
by: Pedro Rainho • 7
The compass application is the most easy, intuitive, usefull and simple to use. It allows you to convert your phone/tablet into a handy compass using device sensors.
Compass application can be used in your daily outdoor activities. If you are a scout or you are just going to travel or camping, this is the application that should be on your phone/tablet and should be used everytime you need a compass.
-Simple and clean interface.
- True North (Default) or Magnetic North.
- Various Themes.
- Update Speed.
- GPS Location (address, latitude, longitude).
Move away from any source of interference, or re-calibrate by Hold the phone with the display facing up and execute a figure 8 motion.
The compass application depends on the device sensors to display compass/location exactly position. If it works perfectly in your device, this means your sensors are perfect. If it's not perfect then might be because of your device sensors of because you need to calibrate.
Tags: compass donate , compasscommander , preview for compass test , aplicativo true norte magnetico norte , bussola true norte magnetico norte , bússola precisa
from 7 reviews
Download Compass donate
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text:
Home >> 5Pcs 2.54mm Pitch 2-Row 4-Bit 8 Pin PCB Through Hole Mounting Slide Type DIP Switches Red
|Product Name
|DIP Switch
|Slide Type
|4 Positions( 2 Row 8 Pin)
|Non-Switching Rating
|100mA DC 50V
|Switching Rating
|100mA DC 24V
|Contact resistance
|50mΩ 24VDC/100mA (at initial)
100mΩ typical, 24VDC/100mA (after life test)
|Total Size
|11.5 x 10 x 9mm / 0.45" x 0.4" x 0.35"(L * W * H)
|Plastic, Electric Parts
|Main Color
|Gold Tone, Red
|Package Content
|5Pcs x DIP Switches
- Features: DIP Type, 2.54mm Pitch, 4 Position, 2 Row, 8 Pin, DIP Switch
- Used on a printed circuit board along with other electronic components and is commonly used to customize the behavior of an electronic device for specific situations.
- Widely used in data processing, communication, remote control and anti-theft alarm system need to manually automatic programming products.
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text:
Simulate Early, Simulate Often... In Rhino
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Gucci Black & Grey Wool Turtleneck Sweater
Black & Grey Wool Turtleneck Sweater from Gucci with geometric pattern. 100% wool. Made in Italy.
Composition: 100% wool
Product care: dry clean only
Product code: 390705 X5608 1173
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Hotel Supreme is located at Vasco-da-Gama, Goa, India. Just a few minutes from the Dabolim Airport, a few kilometers away from the Mormugao Harbor, close to the Railway Station, and located in the heart of the Busy Port Township of Vasco-da-Gama, Hotel Supreme offers you their hospitality and has E...
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text: GENEVA, Feb. 20, 2012 /PRNewswire/ -- STMicroelectronics (NYSE: STM), a global semiconductor leader serving customers across the spectrum of electronics applications, today announced that Carlo Ferro has accepted to focus on the turnaround of ST-Ericsson as chief operating officer of the company. "I have been working closely with Carlo in his role as ST's chief financial officer for the past six years," said Carlo Bozotti, ST president and chief executive officer. "I am confident that his knowledge, drive for results and determination will play a fundamental role in the turnaround of ST-Ericsson. I would like to thank him for taking on this important assignment." Mario Arlati, ST's chief accounting officer and head of corporate external reporting, has been appointed chief financial officer while Ferro is assigned to ST-Ericsson. Investor relations, previously part of the CFO organization, is now under the responsibility of Philippe Lambinet, Corporate Strategy Officer. About STMicroelectronics ST is a global leader in the semiconductor market serving customers across the spectrum of sense and power technologies and multimedia convergence applications. From energy management and savings to trust and data security, from healthcare and wellness to smart consumer devices, in the home, car and office, at work and at play, ST is found everywhere microelectronics make a positive and innovative contribution to people's life. By getting more from technology to get more from life, ST stands for life.augmented. In 2011, the Company's net revenues were $9.73 billion. Further information on ST can be found at www.st.com. Carlo Ferro , Chief Operating Officer, ST-Ericsson Carlo Ferro has been Senior Executive Vice President and Chief Financial Officer of STMicroelectronics since May 2003 and over time his responsibilities have been extended to include investor relations, treasury, corporate communication and – more recently - operation planning, procurement and logistics. He has also been a member of ST's Corporate Strategic Committee. He sat on the Board of Directors and chaired the Audit Committee of ST-Ericsson SA since its inception. Ferro joined ST in 1999 as Group Vice President Corporate Finance. In 2002, he became Deputy CFO, and was promoted to Chief Financial Officer in 2003.


text:
My Body
Kid Icarus
Now then, I need to feed my desires for turning the populace into Tempura.
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Tempura is the best foodstuff to turn into.
At least it's better than being turned into sautéed mushrooms or something.Until the one who turned you into Tempura eats you.
Tempura is the best foodstuff to turn into.
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Mary is young woman left without her husband during the First World War. This is her story.
Any form of constructive criticism here is great guys, I haven't written anything in a long time and I'm sure I'm more than a little rusty! Mostly I'm looking for any historical inaccuracies you may notice, cos I suck at that stuff.
Often when times were trying, Mary would sit quietly for a moment, and recall her wedding day. If the children were refusing to be civil to one another, she would think of the small details, like the creases at the corner of George's eyes as he gazed at her and her dress for the first time. If they were hunkered down in the shelter for what felt like years whilst there was a barrage of shells bombarding them from above, she would think of the cherry blossom on the trees in the garden of the church, caught upon the breeze and settling on the ground before her feet. She had never felt more beautiful or more loved than on that day, and sometimes she wondered if she would ever feel that way again.
Tonight was one of those nights. It was cold, having used the last of the paraffin in an attempt at preventing the children from losing one of their tiny fingers to frostbite. Their teeth were beginning to chatter so hard Mary wondered if they might accidentally bite their own tongues off. Daisy had recently developed a nasty cough too, so Mary had chosen to offer them something of warmth, at least for a short while. Thankfully they were both asleep now, though how they managed to sleep soundly throughout the shuddering of the bombs she would never know. Perhaps it was because they had never really had the opportunity to sleep through any form of peacetime. They were almost four now, and having lived their lives in country that had always been at war meant they didn't know, hope, or expect anything better. Sometimes, Mary felt the same way.
They were sharing the bomb shelter with two of their neighbours tonight. Usually there were three, but the older couple were conspicuous by their absence. She sent a short prayer for their safety, but nothing was guaranteed and in all honesty she was glad of the extra leg room. Still, the Jones' and their tribe were all snoring softly in their own corner; another family blessed with the ability to sleep through almost anything. Mrs Mayhew, a widow who had already lost two of her four adult children to the war effort, sat darning a worn pair of socks in the corner closest to the door. Recently she had had very little of worth to contribute to any conversation. She sent a longer prayer to Mrs Mayhew's remaining two children, and settled in to write another letter to George that she felt sure he would never receive.
When war was declared against Germany, and George had first left for the front, Mary had found almost every day to be a trying one. During this time there had been a lot of reminiscing about her wedding day. Before the war, her life had been going totally as planned. She was married to a fine gentleman, who made a good living at the bookstore he owned, and she was preparing to go back to work as a midwife, after just having two children of her own; twins. This was in 1912, when, looking back, she should have known something bad was going to happen because everything was going just a little too well.
Writing to George had helped her somewhat in dealing with the things she saw each day at the hospital. She knew they were censoring letters coming in and out of the country so that soldiers and their loved ones didn't ruin the illusions that were printed daily in the newspapers. If those pieces of rubbish were to be believed, Britain was winning the war, giving the Germans everything they deserved and more. Yet more young men were heading across the Channel and fewer were returning home. People didn't really talk about this obvious discrepancy; optimism was balancing on a knife's point and, two years into the war, voicing any such concerns would shatter any sort of illusion that there ever could be a winner in what was clearly becoming the destruction of a generation.
She squeezed her eyes shut and gritted her teeth as a bomb detonated nearby, showering them with dust and who knew what else. A couple of the Jones' smaller children shifted uncomfortably under their blankets, whimpering quietly. Their mother placed a reassuring arm around the youngest, hugging the child close. Mary watched her own children just in case they needed her but, as usual, Daisy and Eli were sleeping as soundly as if they were in their own beds. She had the sudden urge to reach out to them, brush the loose hairs back from their heads and pushed herself up from the cold of the concrete floor.
A bomb exploded right above her head. The noise was like nothing she had ever experienced in her life, sending shockwaves through her bones with enough force she felt sure she would shatter into a million pieces. There was enough time to open her mouth and shout the twin's names before the world disappeared from beneath her.


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Need for coal
Our role in the energy mix
UK Coal is proud to supply around 4% of the country's energy needs for electricity generation, and is part of an industry which retains a crucial role in our national energy mix.
Coal currently provides 40% of the UK's electricity, a proportion which rises at peak periods in winter. Coal output in the UK is increasing, and the coal mining industry is worth over £1 billion to the UK economy. 17% of coal burnt in UK power stations is supplied by UK Coal.
Security of UK energy mix over next 10-20 years
Coal plays an important part of the electricity mix in the UK and provided 40% of of our electricity in 2012.
Due to the extreme weather conditions that affect transport movement in winter, electricity generators rely on coal produced more locally to maintain supplies. This highlighted the importance of indigenous coal for use in electricity generation at critical times.


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Talking Peter (FREE) the Pig HD
By Toccata Technologies Inc.
Open iTunes to buy and download apps.
Talking Peter the Pig is the fifth character in iPolly, one of the very first talking applications series. This app is the ad-supported free version of Talking Peter app.
Peter is a smart, adventurous, hard-working fellow who spends most of his time in his workshop.
He is not afraid to try new things for his inventions. He lives off of a special energy drink to keep him running 24/7. Sometimes, he is a little unlucky when accidents like explosions or virus attacks in his lab occur. During his free time, he enjoys a little hip-hop dancing.
***Key Features:***
- Talk to Peter and he repeats in a funny voice
- Press the buttons to make Peter eat and dance
- Poke or swipe his face
- Tap on his tummy and he will fart
- Press buttons to see him working in the workshop
- Record your own greeting and farewell messages and let Peter say it for you
- Set different playback speeds to try different sound effects
With Talking Peter, you get beautiful 3D animations and stunningly detailed graphics that can be enjoyed by the entire family
What's New in Version 4.0.0
- Optimized UI
iPad Screenshots
- Free
- Category: Entertainment
- Updated: 22 August 2013
- Version: 4.0.0
- Size: 134 MB
- Languages: English, Spanish
- Developer: Toccata Technologies Inc
- © Toccata Technologies, Inc.
Compatibility: Requires iOS 5.1 or later. Compatible with iPad.


text:
Abbie DeBlasis received her Bachelor of Science degree from Miami University where she graduated magna cum laude. She then received her Juris Doctorate from Wake Forest University School of Law, graduating magna cum laude and Order of the Coif. While earning her law degree, Professor DeBlasis served as Editor-in-Chief of the Wake Forest Law Review.
Before beginning her teaching career at Belmont, Professor DeBlasis was an associate in the Nashville office of Bradley Arant Boult Cummings LLP, where she focused her practice on regulatory and operational matters for health care clients. Prior thereto, Professor DeBlasis was a senior associate in the Charlotte, North Carolina office of Winston & Strawn LLP working in the areas of syndicated lending and corporate finance and an associate at Kennedy Covington Lobdell & Hickman, LLP (now K&L Gates LLP) practicing in the areas of capital markets and private equity. Professor DeBlasis is a member of the North Carolina and Tennessee bars.
Professor DeBlasis will teach Legal Information and Communication I & II.


text:
Shinan Govani is the National Post's society columnist and social gadfly
Gravity, you say? Even spacier than the calamatious Sandra Bullock film current burning up theatres: that gold-lamé TV movie that hit earth over the weekend
In town, and doing a dinner that started at 1 a.m., was Mila Kunis. And when it came time to eat her 16-ouncer, down in the elusive wine cellar at Barberian's, "she was knawing at the bone," next to her beau, Ashton Kutcher
'Actually, that was the first time I had mulberries.' So, the CEO of Mulberry told me, following a dinner held here recently for the smart British luxury brand
When I myself posted the news on both Twitter and Instagram, Sunday morn, the most common response was — and I quote — "OMG!" "Ridiculous" and "brutal" were some of the other one-word comments
The Pittsburghers are coming! The Pittsburghers are coming! OK, they came. To swanky Forest Hill. Hosting a feast at their home for the storied Warhol Museum
His glasses were foggy. Her skirt was short. They were madly in love
Looks like Mrs. Weston has a new best friend
The TIFF dust may have settled, but the anatomy of a cancelled lunch goes on. And that was L.A.'s George Christy to me giving the dibs on his party-throwing prowess. After 30 long years, his annual bonanza came to an end this year
Toxic friends? Drop 'em! Pals who drain? Boot 'em!
In one of the most celebrated abodes in this town, on a stretch that is its own city state, on a night when Toronto swooshed still with ScarJo and other TIFF-sailing celebs, Arianna Huffington stood, in a room, talking antelope


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Bat The Nats
With the trade deadline on the horizon, the Miami Marlins take on the Washington Nationals this Monday for the first of three games at Marlins Park (501 Marlins Way, Miami). While the Marlins' success this season has been a nice story around the MLB, not many observers believe the team can actually compete for a playoff birth. Still, this series may prove pivotal in helping the front office decide what to do, in terms of unloading talent or adding some depth for the long haul. The Nationals are solid from top to bottom and should be a tough opponent for the Fish. Maybe the Marlins will prove 'em all wrong; maybe you'll just spend a couple of hours in air conditioning at the peak of the South Florida summer, all at one of the cheapest ballparks in the nation. Either way, you're a winner.
Mon., July 28, 7:10 p.m., 2014
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501 Marlins Way
Miami, FL 33125
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American Quilting Traditions: 11 Free Quilt Designs, Quilt Blocks, and More Americana
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"This is such a cute idea. With all the circle pieces of this quilt you can make a very busy quilt to keep baby looking and feeling the quilt. My thought is differnt textures and thickness of fabric would be perfect. Little hands love to feel things. This is a must make quilt on my list."
"Alicia's page had no place to comment so I'm doing it here. The directions say "The edge shouldnt do too much fraying since it has been left with the sheared edge in tact!" What was done for the edges to be called 'sheared' (cut off?), and why does a quilt have tact? (I didn't know they could talk, much less be tactful.)"
"Foundation piecing to me has always meant paper piecing method, only on fabric. Sometimes referred to as the stitch and flip method. I would never refer to EPP as foundation piecing."
"I am interested in making your Frozen Lake. But the instructions are rather vague. Do you square up the HST? If so, to what measurement. Do you square up the pin wheel block? Again, if so, to what measurement? And what is the new block's measurement? And then the final block?"
"What a cute summer pattern! I love the combination of piecing and applique. I would probably use fusible applique as my method. I think it would make this project move along quickly. I like the colors chosen for the project as well. It's adorable for summer. I also appreciate the time frame of a month or so because I think quilting and sewing projects always take longer than we think they will!"
Shoofly Quilt Block Tutorial
By: Natalia Bonner from pieceandquilt.com
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It's not flies you'll be shooing away from this free quilting pattern, but jealous spectators! The Shoofly Quilt Block Tutorial is a cute and unique block, and once you have mastered it, you will want to make it over and over again. Use this free, easy, step-by-step tutorial to combine half square triangles and patchwork to make a fresh and lovely, yet traditional quilt block. Just like the quilts your grandmother used to make, this particular block evokes a sense of nostalgia and comfort that will envelope you every time you wrap up in the finished quilts you have made with this pattern.
Project Type: Make a Project
Quilt Size: 12 inches wide x 12 inches long
Time to complete: In an evening
Primary Technique: Pieced
Difficulty Level: Beginner
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Geography and genography: prediction of continental origin using randomly selected single nucleotide polymorphisms
Recent studies have shown that when individuals are grouped on the basis of genetic similarity, group membership corresponds closely to continental origin. There has been considerable debate about the implications of these findings in the context of larger debates about race and the extent of genetic variation between groups. Some have argued that clustering according to continental origin demonstrates the existence of significant genetic differences between groups and that these differences may have important implications for differences in health and disease. Others argue that clustering according to continental origin requires the use of large amounts of genetic data or specifically chosen markers and is indicative only of very subtle genetic differences that are unlikely to have biomedical significance.
We used small numbers of randomly selected single nucleotide polymorphisms (SNPs) from the International HapMap Project to train naïve Bayes classifiers for prediction of ancestral continent of origin. Predictive accuracy was tested on two independent data sets. Genetically similar groups should be difficult to distinguish, especially if only a small number of genetic markers are used. The genetic differences between continentally defined groups are sufficiently large that one can accurately predict ancestral continent of origin using only a minute, randomly selected fraction of the genetic variation present in the human genome. Genotype data from only 50 random SNPs was sufficient to predict ancestral continent of origin in our primary test data set with an average accuracy of 95%. Genetic variations informative about ancestry were common and widely distributed throughout the genome.
Accurate characterization of ancestry is possible using small numbers of randomly selected SNPs. The results presented here show how investigators conducting genetic association studies can use small numbers of arbitrarily chosen SNPs to identify stratification in study subjects and avoid false positive genotype-phenotype associations. Our findings also demonstrate the extent of variation between continentally defined groups and argue strongly against the contention that genetic differences between groups are too small to have biomedical significance.
A major goal of both the Human Genome Project and the subsequent International HapMap Project was to provide a foundation for understanding genetic variation in the human genome
There has been considerable discussion about the implications of these findings in the context of larger debates about population sub-structure, race and genetics
A variety of different computational methods, including those implemented in the popular programs STRUCTURE and BAPS, have been developed and used to explore genetic variation in populations
In this paper, we use recently published genome-wide SNP data to analyze population sub-structure and ancestral geographic origin. The analysis uses a much larger number of SNPs than has previously been possible and focuses on the use of randomly selected SNPs. We show that one can accurately predict continent of origin in independent data sets using only a very small number of randomly selected SNPs. Genotype data from 50 random SNPs is sufficient to predict ancestral continent of origin in our primary test data set with an average accuracy of 95%. We analyze the comparative utility of SNPs in introns, coding exons, regulatory regions and regions coding for untranslated mRNA for prediction of ancestry. Finally, we show that SNPs that are informative about ancestry are common and widely distributed throughout the genome. Our findings demonstrate how researchers conducting SNP based genotype-phenotype association studies can accurately and reproducibly characterize ancestry using random SNPs, as opposed to SNPs specifically chosen to be informative about ancestry. As genetically similar groups should be difficult to distinguish using only a small number of genetic markers, our results also demonstrate the extent of genetic variation between continentally defined groups and argue strongly against the contention that differences between groups are too small to have biomedical significance.
The International HapMap Project is a large collaborative effort that has made publicly available genotype data for 270 individuals from four different populations: Yoruba in Ibadan, Nigeria (YRI); Japanese in Tokyo, Japan (JPT); Han Chinese in Beijing (CHB), China; and Utah residents with ancestry from northern and western Europe (CEU)
Our primary test data set consisted of 1,586,383 SNPs genotyped by investigators at Perlegen Sciences to study DNA variation in human populations
For each of the test data sets, we limited our analysis to the bi-allelic SNPs that were present on autosomal chromosomes in both the HapMap data and the test set data. There were 1,047,543 and 1,588 such SNPs in the intersection of the HapMap data with the Perlegen and IIPGA data, respectively.
As an initial step in our investigation of genetic variation, for each individual we calculated the average genetic distance to the three continentally defined HapMap groups. We used an allele-sharing distance described by Mountain and Cavalli-Sforza as our measure of genetic distance
Figure 1
Genetic distance from individuals in the Perlegen data to the three continentally defined HapMap groups
Genetic distance from individuals in the Perlegen data to the three continentally defined HapMap groups. Individuals of similar geographic origin cluster together. African-Americans from the Perlegen data set lie in between the HapMap Yoruba and European-Americans, but are much closer to the Yoruba.
Figure 2
Genetic distance from individuals in the IIPGA data to the three continentally defined HapMap groups
Genetic distance from individuals in the IIPGA data to the three continentally defined HapMap groups. Individuals cluster according to ancestral continent of origin but the clusters are less compact than those seen with the Perlegen data because of the smaller number of SNPs. Individuals intermediate between clusters, like those labeled with arrows, may have a high degree of admixture.
The analysis described above shows that when large numbers of SNPs are used, it is readily apparent that genetic structure varies as a function of ancestral continent of origin. Next, in order to evaluate the extent of variation between continentally defined groups, we randomly selected varying numbers of SNPs and then used genotype information from the HapMap individuals to train a naïve Bayes classifier. Naïve Bayes is a simple predictive algorithm that has been shown perform well in a wide variety of situations
Figure 3
Mean predictive accuracy in the test data sets
Mean predictive accuracy in the test data sets. Each data point represents the mean of 100 trials. Error bars depict 95% confidence intervals. Predictive accuracy increases with the number of SNPs used, but is still very good even with only a small number of SNPs.
The Perlegen data set is large enough to investigate genetic variation as a function of SNP type. We used the dbSNP database
Figure 4
Mean predictive accuracy stratified by type of SNP
Mean predictive accuracy stratified by type of SNP. Each data point represents the mean of 100 trials. 95% confidence intervals are shown for the coding non-synonymous SNPs. Confidence interval widths are of comparable size for the other SNP categories. Predictive accuracy is very similar across all types of SNPs, although the small differences in mean predictive accuracy are statistically significant because of the large number of SNPs used in the analysis. For each n (where n is the number of randomly selected SNPs used to build the classifiers), one-way ANOVA was used to test the null hypothesis that means across SNP categories were equal. P-values were less than .01 for all tests where n>5, and p = .07 for n = 5.
We also tested whether some regions of the genome were more informative than others in predicting ancestral continent of origin. SNPs where allele frequency differs significantly between groups are most useful in predicting group membership. As one measure of informativeness, we evaluated pairwise difference in major allele frequency between groups. SNPs where the pairwise difference in major allele frequency was greater than .3 were considered to be informative. Other threshold frequencies were also evaluated and the relative distribution of informative SNPs was found to be similar across a range of thresholds. We also analyzed the informativeness for assignment. This measure was introduced by Rosenberg et al and is a generalization of the difference in major allele frequency to more than two groups
Figure 5
Distribution of informative SNPs by chromosome
Distribution of informative SNPs by chromosome. The primary y-axis (on the left) shows the proportion of SNPs on each chromosome where the difference in major allele frequency between two of the continentally defined HapMap groups is greater than 0.3. Informativeness for assignment is shown on the secondary y-axis (on the right). The distribution of informative SNPs is fairly even across chromosomes. Since almost 4 million SNPs were used in this analysis, the relatively small observed differences are statistically significant however (p < .0001 for the difference in mean informativeness for assignment across chromosomes using one-way ANOVA).
Figure 6
Distribution of informative SNPs throughout the genome
Distribution of informative SNPs throughout the genome. Each chromosome was divided into 10 M base pair bins. Bins near centromeres or near the ends of chromosomes containing only a very small number of SNPs were excluded. Bins contained an average of 3650 SNPs. The figure shows mean informativeness for assignment by bin for the entire genome. The mean informativenss for assignment is relatively similar over all the bins, although the small observed differences are statistically significant (p < .0001 with one-way ANOVA). Results were similar when 1 M base pair bins were evaluated.
In this paper, we use naïve Bayes classifiers trained on data from the HapMap to predict the ancestral geographic origin of individuals from three independent data sets. Even when a relatively small number of randomly selected SNPs are used, classification is accurate and robust. In the large Perlegen data set, predictive accuracy increases to 100% as the number of SNPs grows. This is not the case for the IIPGA test data set. Predictive accuracy as a function of the number of SNPs used, while still very good in comparison to many tests used in biology and medicine, levels off at 95% with two individuals being consistently misclassified. These two individuals were classified incorrectly even if all 1588 available SNPs were used to train the classifier. The two misclassifications were the two African-Americans labeled with arrows in Fig.
Accurate characterization of ancestry will allow investigators conducting genetic association studies to identify stratification in study subjects and avoid false positive genotype-phenotype associations. The analysis we describe here is designed to predict ancestral continent of origin. It could easily be extended to make predictions about smaller units of geography or individuals with a mixed background. This would require more extensive genotype data and well-characterized information about ancestral geographic origin from such individuals. There is only very limited data of this kind currently available, but this is expected to change in the future as genotyping costs decrease. Thus we anticipate that identification of more complex patterns of ancestry will be increasingly feasible as the amount of available data grows. This in turn will allow the development of higher resolution genographic maps and provide investigators designing genetic association studies with more powerful tools for detecting stratification.
In this paper, we have shown that the differences between continentally defined groups are sufficiently large that even a randomly selected, minute fraction of the genetic variation in the human genome can be used to characterize ancestral geographic origin in an accurate and reproducible manner. This argues strongly against the contention that differences between groups are too small to have biomedical significance. Understanding if and how these differences relate to risk of disease and response to therapy is one of the major challenges facing the biomedical research community.
Some have argued that the differences between continentally defined groups are relatively small and that it is difficult to distinguish groups without using large amounts of genetic data or specifically chosen markers. Our results show that continentally defined groups can be easily distinguished using only a small number of randomly selected SNPs. SNPs that are informative about ancestry are common and widely distributed throughout the genome and across SNP types. These findings illustrate the extent of genetic variation between continentally defined groups.
Data sources
The HapMap, Perlegen and IIPGA data sets were obtained from their respective websites
For the IIPGA data set, we used dbSNP annotation files to map the IIPGA identifiers to the official NCBI reference SNP identifier
Nine individuals in both the Perlegen and IIPGA data sets were also genotyped as part of the HapMap project. In our study, these individuals were included in the HapMap data set, but not in the Perlegen or IIPGA data sets.
Genetic distance
The genetic distance between two individuals at a single loci was defined to be zero if the two individuals had the same genotype, 1/2 if they had one allele in common and 1 if they had neither allele in common (i.e. d(CG,CC) = .5 and d(CC,GG) = 1)
Classification with naïve Bayes
We wrote our own implementation of the naïve Bayes algorithm
Identification of SNPs informative about ancestry
To evaluate the distribution of SNPs where allele frequency differed significantly between groups, we computed the pairwise differences in major allele frequency among the three HapMap groups. For the purposes of our study, the most frequent allele in the Yoruba was considered to be the major allele. For each pairwise combination of groups, we determined the proportion of SNPs where the difference in major allele frequency exceeded a threshold value. We investigated how this proportion varied across the genome.
We also used the informativeness for assignment measure to analyze SNPs
where there are
We analyzed the distribution of informative SNPs on both a chromosomal basis and by dividing the chromosomes into bins of a constant size. We tested multiple combinations of bin size and allele frequency cutoff threshold. The conclusion that SNPs useful for classification are distributed across the genome was not sensitive to changes in these parameters.
Comparing means
One-way ANOVA (calculated using Microsoft Excel) was used to compare mean predictive accuracy across SNP types and to compare informativeness for assignment across both chromosomes and bins. The null hypothesis was that all means were equal. P-values less than .05 were considered to be statistically significant.
Authors' contributions
DJA conducted the analyses and drafted the manuscript. QS and GG participated in the design of the study. MFR and ISK conceived of the study and participated in its design. All authors read and approved the final manuscript.
This work was supported by grants from the National Science Foundation, the National Library of Medicine and the National Heart, Lung and Blood Institute of the National Institutes of Health.
New goals for the U.S. Human Genome Project: 1998-2003
The International HapMap Project
The apportionment of human diversity
Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids
Genetic structure of human populations
The application of molecular genetic approaches to the study of human evolution
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
Genetics. FDA races in wrong direction
Classifying humans
Implications of biogeography of human populations for 'race' and medicine
Genetic variation, classification and 'race'
Evidence for gradients of human genetic diversity within and among continents
Dissecting racial and ethnic differences
Race and genomics
Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry
The importance of race and ethnic background in biomedical research and clinical practice
Categorization of humans in biomedical research: genes, race and disease
Bayesian analysis of genetic differentiation between populations
A Bayesian approach to the identification of panmictic populations and the assignment of individuals
Inference of population structure using multilocus genotype data
Estimating African American admixture proportions by use of population-specific alleles
The African diaspora: mitochondrial DNA and the Atlantic slave trade
Population genetic structure of variable drug response
Whole-genome patterns of common DNA variation in three human populations
Innate Immunity PGA, NHLBI Program for Genomic Applications
Multilocus genotypes, a tree of individuals, and human evolutionary history
On the optimality of the simple Bayesian classifier under zero-one loss
dbSNP: a database of single nucleotide polymorphisms
Informativeness of genetic markers for inference of ancestry
The International HapMap Project
Perlegen Sciences Genotype Browser
Automatic Indexing: An Experimental Inquiry


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Osiris Trajan
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Osiris Trajan was a Mannerheim citizen and an officer of the Mannerheim System-Defense Force.
By 1921 PD, he held the rank of Admiral and was considered one of the MSDF's finest flag officers. He served as the commanding officer of Task Force Four. (CS2)


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Q: Can scientists create a black hole in a laboratory? What would it take to create a black hole in a lab?Teodor, Bucharest, Romania
A: This, the second of a three-part article, tells how to create a black hole in the lab. It is difficult. We can't make a black hole in the world we know, because no collider can smash mass into a small enough space. The resulting density has to be the so-called Planck's value of 10^97 kilograms per cubic meter — which man cannot achieve.
Exploding stars can, but we're talking about a man-made lab — a collider that smashes protons together at near light speeds. Our puny efforts don't come close: a density of about 10^34 kilograms per cubic meter is about the best we can do, and that only in 2008 when CERN completes the Large Hadron Collider (LHC)* upgrade.
But what if the universe is different? Maybe the Planck value would be smaller, in that case. Maybe, then, man could generate the needed energies. No maybes about it! Given an extra, nicely warped dimension, we can do it. Here's how.
Suppose the real universe has a space with four spatial dimensions (or more). Furthermore, suppose gravity becomes huge in the extra dimension(s) of space. (I'll explain how next week.)
Then the Planck value shrinks down to a black-hole density the LHC can produce. In fact, the upgraded LHC may be able to crank out a micro black hole each second. Such a black hole's lifetime is only about ten trillion trillionths of a second (10^-27 seconds). In that brief instant, however, we can tell if a black hole was born, because it dies a wild death. According to Stephen Hawking, the dying micro hole will spew hordes of very-high energy particles in all directions. If we see an imprint of such radiation, then we will know the universe is a far stranger place than the one our senses detect. One in which we can create black holes in the lab.
Next week, I shall continue the story of space's extra dimensions and making black holes in the lab.
* A brief note on sizes: 10^-23 is 10 divided by a trillion trillion, a very small number. 10^34 is almost a trillion trillion trillion, a very large number.
Further Reading:
Making black holes in the lab, Part 1, WonderQuest
How black holes trap light, WonderQuest
How black holes die, WonderQuest
Tracking black holes — do they exist? WonderQuest
Fermilab at Work, Fermilab
How do physicists study particles, CERN
Black holes at Future Colliders and Beyond by Greg Landsberg, Brown University
Warped Passages: Unraveling the mysteries of the universe's hidden dimensions by Lisa Randall, Harvard University
Quantum black holes, Scientific American
The Charm of Strange Quarks: Mysteries and Revolutions of Particle Physics by R Michael Barnett et al
(Answered June 11, 2007)
April Holladay, science journalist for USATODAY.com, lives in Albuquerque, New Mexico. A few years ago Holladay retired early from computer engineering to canoe the flood-swollen Mackenzie, Canada's largest river. Now she writes a column about nature and science, which appears Fridays at USATODAY.com. To read April's past WonderQuest columns, please check out her site. If you have a question for April, visit this informational page.
Conversation guidelines: USA TODAY welcomes your thoughts, stories and information related to this article. Please stay on topic and be respectful of others. Keep the conversation appropriate for interested readers across the map.


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A View Of Life From Skid Row
In the first of a five-part series, columnist Steve Lopez takes readers on a tour of Los Angeles' skid row, through the eyes of a paramedic.
"At night, crack-addled prostitutes trick in and out of Porta-Potties down the street. Amputees roll by in wheelchairs. Dealers brazenly peddle slow death. Chavez once watched an argument turn into a knife fight directly across the street from Station 9. The loser, his throat slashed, crossed the road for help, then collapsed and died in the firehouse driveway."


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It?s not often that you can call a brand new car ?old?. But that?s the case for Ford?s Kuga.
The compact SUV has been on sale in Europe for nearly four years, but will finally go on sale in Australia in March. And even then, Ford says it will only sell the car for 12-18 months before an all-new model comes on line to replace it.
The Kuga won?t be a bestseller either. Supply is limited to just 200 units per month. To put that into perspective, the top-sellers in this segment ? such as Subaru?s Forester and Toyota?s RAV4 ? regularly shift more than 1000 cars every month.
The ?entry-level? Trend is priced at a steep $38,990 (plus on-road costs); and the top-end Titanium, from $44,990. It was the latter that we tested during our test, although the car was not wholly indicative of the model that will be sold here. It was fitted with 19-inch alloys, whereas our version will come with 18-inchers, and the Panoramic glass roof that will be standard in Australia wasn?t fitted.
Comparing the interior of the Kuga to more recent releases from Ford, such as the Ranger and Focus, you instantly notice the age of the car?s design. It?s simpler than newer Fords ? and a little dull ? but everything is easy to use and there are soft-touch plastics throughout.
The leather-lined front and rear seats are comfortable and supportive, and the back offers enough room for taller passengers to fit comfortably. The driver gets a good view of surroundings, too, thanks to a high seating position.
However, the Kuga?s storage falls short of many of its rivals. The glovebox is reasonable, and there?s a covered centre console that hides the USB and auxiliary inputs, but the front only has two small cup-holders and very slim door pockets, while in the back there are no door pockets at all. Another notable omission is rear air-vents.
The boot is on the smaller side at 360 litres, but will still fit a pair of suitcases and couple of other bags without too much trouble (cargo space expands to 1355L with the rear seats folded flat). Another plus of the boot is the split tailgate, which allows you to open the glass section independently of the full door, much like a mini hatchback.
Unfortunately, though, the boot doesn?t have room for a full-size spare, getting a space-saver instead.
On the road, the Kuga drives commendably well. The steering is one of its highlights, offering fantastic weighting and, unlike some of its rivals, good driver feedback with a real connected-to-the-road feel.
The ride, too, was surprisingly good ? particularly considering the size of the wheels and the low profile tyres of the model we drove. It was comfortable, verging on cushy, and was not upset by bumps or potholes. It also performed well over a few corrugated gravel sections, with the body remaining well controlled.
Through corners it did feel slightly heavy, but the traction of the all-wheel-drive system meant it never felt loose or skittish on the road.
Despite all of its promising points, perhaps the most frustrating thing about the Kuga was the amount of road noise transmitted into the cabin over coarse-chip sections of road. We hope the Australian-delivered versions with their smaller wheel and tyre packages are considerably better in that regard.
The only engine available in the Kuga is a 2.5-litre five-cylinder turbocharged petrol unit, the same that was fitted to the now-defunct Focus XR5 hot-hatch.
It pumps out a generous 147kW of power and 320Nm of torque, but pays a significant price in its fuel consumption ? officially rated at 10.3L/100km ? and Ford recommends the use of the more expensive premium (95 RON or better) fuel, too.
We didn?t see anywhere near the claimed consumption figure during a mix of motorway, suburban and country touring roads. Our average was usually in the 12.0L/100km range, stretching as far as 14.9L/100km following a slow, hilly section held up by logging trucks.
Those numbers don?t fill us with confidence, especially considering the vast majority of these cars will be sold to urban-dwellers, who, in one way or another, will likely see similarly high figures during their commute.
However, the engine gains momentum smoothly rather than forcing you back in your seat. You really have to put your foot flat to the floor to feel the power.
The gearbox does what is needed of it, and was particularly smooth in inner city conditions. But we did notice it could be a little doughy in its reaction times, often holding onto a gear for a fraction too long and making the car run out of puff rather than kicking down a gear.
There is no doubt the Kuga is a car that Ford needed. It blends a stylish, er, ?new? look and decent equipment levels with a an above average driving experience and a good engine and transmission combination.
But the big question for buyers is whether to dive in now and get the current model, or wait the 12 to 18 months for the new one, which promises to be offered with more efficient engines and a cheaper entry-level variant.
Follow Drive.com.au on Twitter @Drivecomau


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Panic en la Playa Seis brings together the Panic community for one of the most anticipated vacations of the year. Seis will feature four full Widespread Panic shows in the open air Concert Courtyard with the Caribbean Sea as the backdrop. Additionally, guests will be treated to sunset lagoon shows from Southern Soul Assembly and Bloodkin as well as late night sets from the Playa Allstars and Orgone. Get down with your Panic fam in a setting like no other!
- Widespread Panic: Performing four full shows
- Playa Allstars feat. George Porter Jr., Karl Denson, Eric Krasno, Ivan Neville, Col. Bruce Hampton, Jennifer Hartswick & Terence Higgins: Performing two late night shows
- Southern Soul Assembly feat. JJ Grey, Luther Dickinson, Anders Osborne & Marc Broussard: Performing one sunset acoustic show
- Orgone: Performing two late night shows
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Entomology News and Information:
Breakout Season for Pest Mites
|The Stethorus lady beetle (aka the spider mite destroyer, top) is one of many important mite predators. Both the small adult (left) and larva
(right) are predators of spider mites (bottom).
The hot, dry summer of 2012 was favorable to pest mites on a variety of crops in Utah. An early summer visit to a peach orchard in Weber County revealed trees with a silver sheen to the leaves, the classic representation of damage caused by the peach silver mite. These trees were also found to be teeming with the more cosmopolitan two-spotted spider mite. Visits to corn, melon, pumpkin fields and turf fields from Millard to Cache counties also showed flare-ups of two-spotted spider mites and the Banks grass mite.
Spider mite damage is commonly seen as "stippling" or yellow to white speckling where the mites have fed and killed the plant cells. Eventually, heavy feeding results in the yellowing and bronzing of leaves. Spider mites and their webbing can best be detected on the undersides of leaves with a hand lens.
Mites are usually held in check by predatory arthropods such as the Stethorus lady beetle, minute pirate bug, and predatory mites. One of the main contributors of mite outbreaks is insecticide applications that have non-target effects. Some insecticides, such as pyrethroids and organophosphates, kill predatory arthropods that would normally feed on pest mites. Other insecticides, such as carbaryl or neonicotinoids, can trigger increased mite activity and egg production that lead to mite outbreaks.
Recent research suggests that neonicotinoid insecticides alter plant chemical defenses, making plants more susceptible to mites. During warm, dry conditions, like in 2012, mites have shortened generation times and the population can build up rapidly. Mites feed more in dry conditions because low humidity evaporates excess water that they excrete. Unfortunately, predators are unable to keep up with this rapid increase in the population in part because they are less effective in hot, dry conditions.
It is not uncommon in our region, particularly during an extended, dry season, for plants to become drought-stressed, which benefits mites. Water-deprived plants undergo changes in plant chemistry such as increased availability of amino acids, allowing mites to thrive. Proper irrigation practices can reduce plant stress and help plants from succumbing to mite feeding and damage. Also, frequent overhead irrigation and rain can physically wash mites from plants and help decrease mite populations. Note that overhead irrigation will not reduce mites that are already at economically damaging levels.
Mite management needs to be proactive and preventive. Strategies include conservation of mite predators by avoiding broad-spectrum insecticides, correct identification of the pest mite, monitoring the mite's population growth, and using action thresholds when available. Dust buildup on foliage from dirt roads, which benefits pest mites and hinders predators, should be kept to a minimum by washing plants or altering the road surface.
When mite populations exceed predator populations, a selective miticide will provide the best suppression, such as: Acramite, AgriMek, Oberon, Portal, and Zeal for commercial, and insecticidal soap or horticultural oil for residential (check label for listed crops). Be aware that some insecticides such as bifenthrin products list mites on the label as a pest that it controls; however, the results may be less than expected compared to a selective miticide and in some cases, may be worse due to the non-target effects previously described. Crop fields with a long history of miticide applications may also find less favorable results with these products due to resistance in the mite population.
-Ricardo Ramirez, Extension Entomologist
Alston, D.G. and M.E. Reding. 2011. Web spinning spider mites. Utah State University Extension Fact Sheet. ENT-151-06
Fleischer, S. 2012. Mite Outbreaks in Hot Weather. Penn State University Extension. Vegetable and Small Fruit Blog.
Szczepaniec, A., et. al. 2011. Neonicotinoid insecticide imidacloprid causes outbreaks of spider mites on elm trees in urban landscapes. PLoS ONE 6(5): e20018.