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The leading solution for wealth management
Tower is the TechRules leading solution for wealth management. It is the answer to obtain a complete life cycle in advisory and open a new communication channel with the clients. Investment proposals, reporting and portfolio management, amongst other services, will be substantially improved with our innovative solution. Our tools empower advisors to get a whole picture of their clients and align with their strategy. This perspective reinforces the relationship between advisor and client bringing confidence and retaining them.
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25,800 Gallon VCM Tank Car
This 25,800 gallon (US) non-coiled, insulated tank car has been designed with a 263,000 lb gross rail load for the transportation of vinyl chloride (VCM). The car is equipped with a 22 5/8 inch manway, and a 300 psi tank test pressure. Top fittings consisting of 2- and 3-inch valves and a 60 inch MGD. This car is not heated, but does come equipped with 3 inch thick fiberglass insulation bonded to a 0.65 inch thick thermal ceramic blanket. Various options for loading/unloading valve configurations are available depending on the service requirements.
- Dimensions
Length Inside N/A Width, Inside N/A Length, Over Couplers 53' 2 1/2" Width, Extreme 10' 8" Height, Inside N/A Door Opening, Width N/A Height, Extreme 15' 6" Height, Top of Rail to Threshold N/A Clearance PLATE C
- Weight/Capacity
Light Weight 84,000lbs. Gross Rail Load 263,000lbs. Load Limit 179,000lbs. Cubic Capacity N/A Gallon Capacity 25,823
- Curve Negotiability Radius
Uncoupled 150' Coupled to Like Car 191' Coupled to Base Car 190'

subset: commoncrawl


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is noncompulsory but will drastically multiply your chances of getting interest from other Christian members on the site. Type a little about yourself, your interests and upload your best photo.
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Messengers have arrived from Darkshine to bring news of one League's marvelous progress!
"Black Death 2" has done the impossible, ascending to the 10th level of the "Legionaries of Stormfall" achievement! They are the first League in Stormfall's history to conquer this epic challenge!
Black Death was formed from ten different Leagues, all brought together by our creator and Grand Marshal Peter Baker. Our founding members also included friends from Total Domination, such as Elisa Goor, our longest serving Black Death 2 Marshal.
The Lords and Ladies of Black Death 2 have always been diverse – plenty of couples and family members have joined our ranks from all over the world. We make sure to have lots of fun together every day, so we have one very busy chat!
Like any League, we have had good days and bad days, but Black Death 2 is a family – we come together in times of need to overcome hard times.
We will never stop working on the Achievements. Just in the last week, we managed to gain achievements in all 17 of the possible categories.
As for the long term, we'll take it day by day - there are some very tough achievements to complete on the way to level 10!
Raiding has always played a big part in the history of Black Death 2, and as such, we have successfully run a raiding competition every week for the last 16 months. We give prizes to our top 30 Raiders every week.
We were also monitoring the progress of the only other League who could challenge us in our mission to get Legionaries of Stormfall level 10 first. As we neared achieving our goal, we made sure our members knew that we expected them to raid.
I would say that we have never lost members because of war… but yes, we have lost members because they could not meet our requirements, or because they never had time to play.
I believe we have earned our members' dedication; we always try to help every person, even if it's just to share knowledge.
We have a great team of officers who usually share workload, but every day we see our members stepping up to help others. We are very proud to have so many people offer to help with our daily tasks.
When it comes to recruiting new members, we have a few options. Black Death has four boot camps where we train new recruits before moving them to other BD Leagues. Black Death 2 has a second, sister League to which we can move members if necessary. To date, we've merged four other Leagues into Black Death 2 to create a very active membership. We encourage all of our members to bring in friends and family as well.
And of course, we can't forget all the great work our past and current Recruitment Officers have done.
I would change nothing at all. We've had our ups and downs along the way, but they've only brought us all closer together. They've turned our League into a family.


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Anyone who owns a Acura knows that when it comes to maintaining their car, truck, or SUV only the highest quality replacement parts will do. It's not a regular occurrence that you find yourself in need of a replacement Drive & Serpentine Belt to fix your vehicle. Acura car, truck, or SUV owners have become used to a certain level of sporty handling when driving their MDX around town. When your Acura MDX left the factory, it was destined for a driver who prioritizes unique styling in their automobile.
Your engine's accessories would not function properly without the use of your serpentine or drive belts. Your Acura MDX drive or serpentine belts use the momentum from the crankshaft to turn the pulleys on your accessories. Due to the pressure these belts are operating under, they run the risk of suddenly breaking or wearing down over time; potentially leaving your engine without the use of its alternator, power steering, or more. Acura MDX engines with just one belt that joins all of the accessories to the crank pulley have a serpentine belt, while more than one would all be called drive belts.
Buying new Acura parts from www.carpartsdiscount.com means you are taking advantage of the most superior original and aftermarket replacement MDX parts on the internet. When your Acura requires a new replacement Drive & Serpentine Belt, there's no need to waste time looking anywhere other than the authority, Car Parts Discount. Get your MDX back on the road with the highest quality repair parts from the experts at Car Parts Discount. Need 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001 Acura MDX Drive & Serpentine Belt parts? We've got them right here.


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Carlos Condit talks with Ariel Helwani about his upcoming title fight against Robbie Lawler at UFC 195. watch video >>
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What Is The Stockton Slap? (Nick Diaz, Nate Diaz) watch video >>
Stockton city councilman Michael Tubbs had the honor to introduce Democratic presidential candidate Bernie Sanders at the Vermont senator's downtown Stockton rally yesterday morning and during his watch video >>
Nick Diaz filmed going ninja mode; Holly Holm training in the gym with friend; Michelle Waterson teaching combos; Robbie Lawler and Carlos Condit edit; Anderson Silva; Anthony Johnson and much more! watch video >>


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Doctor insights on:
Brain Tumour Causing Damage To Optic Nerve
If i had brain tumor and it was effecting vision would my dr see pressure on my optic nerve?
Maybe not: Some brain tumors do not put any pressure on the optic nerve. On the other hand, there are lots of other causes of vision problems. It is probably not worthwhile jumping to conclusion that your vision problem is caused by a brain tumor. ...Read moreSee 1 more doctor answer
Brain Tumor (Definition)
Brain cancer refers to cancer located in the brain. It can occur from a metastasis from a tumor in another part of the body or can originate in the brain. Symptoms of brain cancer include headaches, weakness, dizziness, seizures, and blurry vision. It can sometimes be asymptomatic as, for example, in patients with small cell lung cancer. It is always best to use MRI with contrast to make an evaluation, since using a CT can cause you to miss ...Read more
Can you list eye manifestation due to brain tumor compress optic nerve?
Visual field defects: As the tumor compresses the optic nerve, there will be a visual field defects. This can be in one eye if it happens before the optic chiasm or in both eyes if it happens after the chiasm. If there is any visual field defects, the tumor should be removed. ...Read moreSee 1 more doctor answer
My 7 year old son has to get an MRI after an eye exam that showed his optic nerve is larger than normal. Could this mean he could have a brain tumor?
More complicated : This is more complicated than yes or no. Let's not jump to the worst thing first. Many reasons can lead to optic nerves that are different. Let's see what is causing this finding. ...Read more
If an eyes exam by eye doctor come normal no pressure in eyes or the optic nerve can that mean it is very unlikely I have a brain tumour?
Sort of: A normal eye exam does not rule out a brain tumor-- only brain imaging would do that. Of course, brain tumors are quite uncommon to begin with. You might see a neurologist if you have concerns about this. ...Read moreSee 2 more doctor answers
Can sinusitis be a cause of swollen optic nerves in both eyes? Scheduled for an MRI but very nervous hoping its not a brain tumor. Thanks!
Highly unlikely: In rare cases, very severe sinusitis could affect the blood supply or blood drainage of the optic nerves. However, a person with this problem would likely have other symptoms as well, such as severe headache, other cranial nerve palsies or frank meningitis. ...Read moreSee 2 more doctor answers
Is radiation for a squameous cell cancer tumor behind eye on optic nerve
next to brain safe or could it cause necrosis of brain. Do I need proton?
Palliative: Retrobulbar optic nerve involvement with metastatic tumor rare. Squamous malignancies are very few in that area. Chemo and RT given have mostly been palliative. Gamma knife therapy might be better than trying proton beam. With RT and chemo results in general have not been that encouraging. ...Read more
If blood work, neurology report were normal, and doctor did an examination, he suspects no brain tumor, no CT scan, am I most likey safe? Optic nerve looks good, just have gallstones that cause nausea
Clarify question: I am sure what is your question or concern at this time.Can you clarify your concern or question. ...Read moreSee 1 more doctor answer
Can a brain tumor cause problems in other parts of the body? (ex: stomach ulcers, sickness) if a brain tumor is present near the optical part of the brain, can it cause problems in the body such as sickness?
Yes and no: The tumor itself does not cause other problems but the side effects of the medicines used in treatment, like steroids, can. Optical tract brain tumors do not usually cause symptoms other than visual disturbances unless they are very large in size. ...Read moreSee 1 more doctor answer
Are sparkles in vision a sign of brain tumor? Why? Because of optic nerve or chiasm pressure?Or occipital/parietal lobe pressure? Please elaborate
Sparkles: Actually seeing lights or flashes is more likely a sign of a retinal issue, migraine or vascular problem than brain tumor. ...Read more
Nerve (Definition)
The brain and spinal cord communicates with what is occurring in the internal organs and limbs by nerve fibers where are like electrical wires with insulation (myelin) and the "copper" (axon). Within brain and spinal cord these nerves connect to other nerves via synapses on both axons and dendrites. A nerve can carry information regarding sensations, and ...Read more
Neoplasms (Definition)
"tumor" literally translates as "mass", so even a fresh bruise could be called a "tumor". Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. These may be benign or malignant; "malignant" = cancer. In everyday usage, we use "tumor" ...Read more
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- Brain tumour causing sudden compression of optic nerve
- What are the causes of optic nerve damage?
- Glaucoma causes damage to the optic nerve through increased
- Ask a doctor a question free online
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- Damaged optic nerve symptoms
- Damage to optic nerve symptoms
- Talk to a neurologist online


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Sentence #627960
Because they "could not both support wife and airplane" the two brothers spent their lives as bachelors.
You cannot translate sentences because you did not add any language in your profile.
Mivel "nem tudtak egyszerre feleséget és repülőt is eltartani", a két fivér agglegényként élte le az életét.
Saying they could not support both a wife and an airplane, the two brothers therefore spent their lives as bachelors.
Both brothers said that they couldn't support both a wife and an airplane, so they spent their lives as bachelors.
The reason both brothers gave for remaining bachelors was that they couldn't support both airplanes and a wife.
Prétextant qu'ils ne pouvaient entretenir à la fois une femme et un avion, les deux frères sont restés célibataires toute leur vie.
▲ Fewer translations
"both support wife and airplane"
shouldn't this be:
"support both wife and airplane"


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With less than a week of summer vacation remaining, Central Hardin High School Principal Tim Isaacs led a Kentucky State Police trooper through the hallways while pointing out aspects of the school
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Quella, God of Dream
4,575pages onAdd New Page
this wiki
this wiki
Quella, God of Dream[1] is a mentioned character in Dark Souls II.
Quella is the god of dreams and a representation of the "dreamworld", symbolized by the talking[2] "spirit tree"[3][2]. Quella is mainly associated with the spirit tree, divine power[2] and the color blue.
- ↑ Name-engraved Ring selection.
- ↑ 2.0 2.1 2.2 Grand Spirit Tree Shield description.
- ↑ Spirit Tree Shield description.


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Going to Karaoke is usually a social experience with friends and singing for a crowd of strangers, but the Solo Karaoke Rooms completely change this concept.
Now there is store in Japan, specializing in one-person Karaoke booths. The rooms have a chair, a microphone, headphones and a small screen to show the lyrics to the singers. The area is sound-proof, so your voice won't carry, and if you are wondering who would Karaoke alone, the targeted audience is people who want to practice their vocal cords before going to the big party and rocking it. I would also add to this list people who are tired of singing in the shower and are looking for another avenue where they can sing without embarrassing themselves.
Singular Singer Booths
More Stats +/-
20 Humiliating Innovations
17 Karaoke Creations
32 Innovations for Mediocre Singers
Song-Induced Striptease
Portable Karaoke Machines
The Solo Karaoke Rooms Allow one to Work on Vocals
Dec 4, 2011By: Parul Rohatgi -
References: newlaunches & japanprobe
References: newlaunches & japanprobe


text: Vaginal clear cell carcinoma in a Japanese Black cowMasaki MICHISHITA, Makito HORI, Rei NAKAHIRA, Kimimasa TAKAHASHIThe Journal of veterinary medical science2016During artificial insemination of an 18-year-old female Japanese Black cow, a mass that was of a hen's egg size was found in the vagina. On necropsy, the firm mass, measuring approximately 3.5 × 3.5 × 3.0 cm, was located at the superior region of the vagina. The cut surface of the mass was gray-white in color with occasional necrotic or hemorrhagic areas.… (More)


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Waveform will be available soon!
All rights reserved. No usage without prior licensing. Please be fair. Thank you!
Quiet intro followed by a strong metal riff with sound design. A typical solo guitar is presenting the main theme.
Sawing solo guitar in front of a solid Rock background shakes the establishment
Soft Hard Rock with a melodic solo guitar
This funny track is creating good vibrations. Synthis, solo guitar and lots of fun.
Cool track, cool production! Modern funk with typical solo guitar and Moog synthi lines. This is the right address for fun, power and groove!
A very pulsing song, hot solo guitars, acoustic and electronic drums.
Classic headbanger sequence with a vertigo groove and a hardcore solo guitar
Sweet solo guitar intro guides us into an ultra smooth bossa nova. A quintet of sax, lead guitar, rhythm guitar, bass and drums wrap us up in warm and sensual melodies whilst the guitar and sax have their own cool solo spots.
Rapid rock with strong solo guitar, guitar-passages in thirds and a lot of action. A quiet middle section forms a contrary middle part.
Dance euro-pop!! Happy and energetic dance. Solo guitar and synthesizers & Teen/Pop sound.
Beautiful classical solo guitar track
Heated and unpredictable. Hardcore riffs and a solo guitar, which vies with the next volcanic eruption
Extravagant solo guitar in front of a confusing background
Heavy and dashing Metal track for headbangers (without solo guitar)
Psycho trip through different worlds of style, always with a wild solo guitar in the front.
Very mellow and beautiful solo guitar piece with ornamental string and tuned percussion parts creeping in and out. Lush sounds and emotive chords make this a nice peaceful, sentimental and thought provoking track. Would suit romantic, dramatic , documentary projects. contains guitars of all kinds and strings.
Pop Reggae ballad with wah wah guitars and marimba. Slow, swaying feelgood reggae. Caribbean, Hawaiian, Tropical feel, Wah-wah lead lines. Also available as an Underscore version without the main/lead solo guitar lines.
Pop Reggae ballad with wah wah guitars and marimba. Slow, swaying feelgood reggae. Caribbean, Hawaiian, Tropical feel, Wah-wah lead lines. Also available as an Underscore version without the main/lead solo guitar lines.
Gritty and sombre solo blues, played on tremolo'd electric slide guitar.
An acoustic guitar solo that moves along at an upbeat tempo in this blues track. Lively and playful, it creates a spirit of hope and enthusiasm whilst keeping to its bluesy roots. Delicate and intricate playing ensure the music has lots of emotion.


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This step is voluntary but will drastically enhance your chances of getting noticed by other people on the website. Introduce yourself, your pasttimes and upload a nice photograph of yourself.
Utilise our website's cutting-edge search to encounter members who match your desired criteria. Or just scan through listings and encounter singles that pique your interest.
Discovered someone who interests you? Drop them a line or just a wink and wait for their response. With a little luck you'll be on your way to uncover your suitable match.
It only takes a few minutes


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DAY 16: Cougar D has solid day in coverage
"There were times the defense had great coverage," coach Paul Wulff said. "That was very encouraging."Sophomore safety Chima Nwachukwu, who switched positions with fellow starter Alfonso Jackson and moved from cornerback in the spring, said much of the credit for the defense's improved play should go to new secondary coach and co-defensive coordinator Chris Ball.
"He just raised our expectations," Nwachukwu (pronounced WATCH-uh-koo) said. "He expects perfection on every single play. That's what we're striving for this season."
THE COUGARS RETURN nine starters from a defense that ranked at or near the bottom of the Pac-10 in virtually every meaningful statistic.
Nwachukwu, who started as a true freshman, said experience and new schemes have made the Cougars better on defense and pointed to the linebackers' improved play as a key component.
"Altogether, we're cohesive," said Nwachukwu. "The linebackers, corners and safeties are all on the same page, and the D linemen, they're getting a rush on the quarterback."
Even when the Cougars Thursday chose not to mount an all-out pass rush on certain plays, the secondary and linebackers often locked up would-be pass catchers. Senior defensive end Matt Mullennix joined in on the fun by intercepting a short pass over the middle by Gary Rogers. Linebackers Cory Mackay and Sam Tennant "sacked" elusive backup quarterback Kevin Lopina on consecutive plays with the No. 2 defense.
Rogers found tight end Devin Frischknecht in the end zone for a 13-yard touchdown. Backup tight end Ben Woodard also hauled in a TD pass, a 9-yard strike from Lopina.
Reigning Pac-10 receiving leader Brandon Gibson sat out practice with a sore neck. Jeshua Anderson (hernia surgery) is expected to miss the first three games. Daniel Blackledge, the third wide receiver originally projected to start, has just recently returned but is being limited to light work due to a hamstring.
Wulff said Gibson "probably" will play Friday afternoon in the team's second and final full scrimmage. Admission is free, with a 2:30 p.m. start scheduled at Martin Stadium.
COUGAR ROOKIE Patrick Rooney, bidding for the kicking and punting jobs (projecting starting punter Reid Forrest's surgically repaired ankle is not expected to be ready in time for the opener), experienced a rough day at practice.
After mishandling three snaps during punting drills, Rooney stumbled a bit on his first two field-goal attempts and missed, then a high snap threw off his timing and he missed his third try.
He did, however, connect from 51 yards on his other attempt.
Wade Penner and Nico Grasu, battling Rooney for the kicking job, went 3-for-4 while kicking from 40, 43, 47 and 51 yards. Penner came up short from 51, but the big-legged Grasu made it with ease.
COUGAR RECEIVERS Michael Willis and Kevin Norrell, filling in at the slot position vacated by Blackledge, continued their strong play. Starting offensive tackles Vaughn Lesuma (back) and Dan Rowlands (shoulder) sat out. The coaches continue to experiment across the board and Matt Eichelberger was the starting defensive right tackle, Toby Turpin had been with the No. 1 defense yesterday.
Another first year Cougar, junior Myron Beck, started with the 1's at safety and broke up a potential touchdown pass in the end zone.
Wulff, who rarely runs the Cougars at the end of practice, wrapped things up Thursday afternoon by pushing the troops through a series of long range sprints. Players who consistently finished at or near the front of their groups included Rogers, Tennant, No. 3 quarterback Marshall Lobbestael, reserve safeties Kyle McCartney and Easton Johnson and, for the linemen, Cougar rookie Zack Williams.
WULFF SAID THE Cougars overall were "a little flat" at practice on Thursday, which he chalked up partly to the length of fall camp. The Cougars have taken just one day off since practice began Aug. 5 and on seven occasions have held two practices in one day, not counting split squad sessions.
"We're a little tired, probably more mentally than anything," Wulff said. "Probably like in most camps."
NOT ONLY ARE the Cougars the consensus "favorites" to finish last in the Pac-10 this year, but there could be a predicted drop-off next season, since half the 2008 starters figure to be seniors. The talent and leadership of players like Gibson, Rogers and middle linebacker Greg Trent will be difficult to replace.
The 2010 Cougars are starting to shape up as a potential powerhouse, thanks in part to a 2009 recruiting class that Wulff rates "very good" thus far. All six of the known players who have made verbal commitments to the Cougars -- verbal commitments are non-binding and won't become official until February's Signing Day -- are Scout.com national top 75 picks for high school seniors at their positions.
Darren Markle from Mountain View High in Meridian, Idaho, is WSU's top-rated recruit. He's ranked the No. 25 middle linebacker in the nation.
"We're getting guys we're shooting for and guys we feel are going to fit our style of play," Wulff said. "Guys who truly want to be Cougars. "I think they can see the vision, where we're headed."


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ED Magedson – Founder
Ripoff Report
HMS Movies27205 Jones Loop Rd., 79 Punta Gorda, Florida United States of America
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
I thought I bought a DVD from half.com, a resource that has always been reliable in the past, on the Olympics. I never received a confirmation for my order or the order. My credit card statement posted amount for the DVD as $11.58, fine, purchased on 8/5/09. On 8/6/09 is another HMS Movies transaction for $19.95 that I am unable to decipher the rhyme or reason to.
I now have to spend hours on the phone dealing with my credit card company to try to find out what these charges are. I have since tried to locate HMS Movies and cannot find them, so I cannot even contact them. I've read other complaints that this $19.95 is a monthly charge.
Talk about Frisked for wanting to watch the Olympics!!
This report was posted on Ripoff Report on 08/22/2009 03:11 PM and is a permanent record located here: http://www.ripoffreport.com/reports/hms-movies/punta-gorda-florida-33982/hms-movies-i-thought-i-was-ordering-a-dvd-from-halfcom-i-never-received-confirmation-483962. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
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Gold Coast Pier Longboard Skateboard Complete Red - $64.95
Putting the "Rad" in Radius. Clean lines, great colors, and a little flip-flop-flair make the Pier the freshest board on the boardwalk. The Pier is a 27" Shovel, a perfect board for getting from here to there with a trick or two in between. The Pier features super soft 57mm Vicious wheels, so when the road gets rough you keep the fillings in your teeth.Key Features of the Goldcoast Pier Longboard Skateboard Complete: 27" long x 7.5" wide, 15" wheelbase 7ply Canadian maple Die Cut grip tape Shred Boot wheels, 57mm, 85a Century 129mm regular pivot trucks 93a Bushings Century .5" Flat risers Genuine goldcoast a7 bearings - $64.95


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This step is voluntary but will dramatically multiply your chances of getting noticed by other people on the site. Let people know a bit about yourself, your pasttimes and upload some good photos of yourself.
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text: Heya Peeps!! Kitty here! Hmm... what should I write? Well, firstly I love reading, always have done + probably always will! My favourite books are definitely the Twilight saga, they are soo good; but i don't get how stephanie meyor can make a story funny, scary, adventurous and so romantic at the same time and the qualilty is so amazing too! Not Fair! I also love loads of other books, Cherub series, Harry Potter, Any Michael Morpurgo books, and Twilight!!... (I could fill pages and pages!) I also love films! Twilight, New moon, Avatar are all amazing! Better finish this off later cause my laptop is running out of battery! C ya, Kitty


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Can Your Immune System Affect Your Ability to Make Friends?By Jill Suttie | August 8, 2016 | 0 comments
New research reveals surprising ties between our immune systems and our social behavior.
We at Greater Good often write about the importance of social connection in our lives. Many studies suggest that people with stronger social ties tend to be happier and healthier than those without them.
Now, new research may provide a clue about the connection between social functioning and health and well-being. Neuroscientists at the University of Virginia have uncovered a pathway through which immune system molecules involved in fighting off infections impact brain activity and social deficits in mice.
In their experiment, mice bred without normal immune function—known as SCID mice—were found to have dysfunctional social behavior, showing no preference for interacting with other mice when given the opportunity. By monitoring the brain activity of these SCID mice when exposed to other mice, the researchers found a pattern of hyper-connectivity in the prefrontal cortex, which seemed to predict their social resistance.
Interestingly, this particular brain pattern has also been found in humans with autism, schizophrenia, and dementia, says researcher Anthony Filiano, one of the authors of the study, suggesting that a compromised immune system could affect social functioning in humans, too.
"We have more and more evidence linking immune dysfunction with neuronal and behavioral dysfunction," says Filiano. "The potential to target the immune system for neurological disorders is what's most exciting about this work to me."
Interferon-y: The new social molecule?
By testing different molecules involved in immunity, Filiano and his colleagues were able to zero in on interferon gamma (IFN-y), a molecule associated with fighting invasive germs and bacteria. Introducing IFN-y into the cerebral spinal fluid of SCID mice made them interact socially with other mice again, by inhibiting the hyperactivity in their brains that might otherwise impair that normal social behavior. This suggests IFN-y helps regulate social connection, at least in mice—and possibly in humans as well.
"We think interferon gamma is acting like a rheostat, or a break, to control the brain region from over-activating [in social situations]," says Filiano.
Just a few years ago, no one would have been looking for these kinds of interactions between immune system molecules and the brain, because researchers assumed that the blood/brain barrier in mammals prevented such communication. But last year, fellow researchers at UVA published a study blowing away that idea by uncovering hidden lymphatic tissue linking the brain and immune system together.
"We're starting to understand that there's a lot more communication between the brain and the rest of the body than we previously thought," says Filiano.
Immunity and social connection
So, why would the immune system interact with our brains to increase or decrease social behavior particularly?
According to Filiano, it's because social organization is important for survival—for protection, for foraging, for reproduction. But, with increased social interaction there's also an increased risk of infection from contagious disease; so our bodies needed to evolve somehow to mitigate the risk. IFN-y flowing in the blood stream basically alerts the brain that it's OK to be close to others, because it's there fighting infections.
"What we're thinking is that interferon gamma has evolved to more effectively control that anti-pathogen response as organisms are aggregating," says Filiano.
What might this mean for the rest of us? Filiano says that while it's fun to speculate how the immune system controls our behavior in general, the radical re-engineering of mice is something one could never do with humans. But, he thinks that small changes in immune systems and molecules could, perhaps, influence our behaviors, and we would probably never know it.
The research has only just begun. Filiano is especially intrigued by the possibility of harnessing the immune system to help people with neurological diseases. There are literally hundreds of immune cells and immune system molecules with disease-fighting actions that may hold the key to behavior, he says.
"Thinking about big picture and moving forward, there are a lot of different molecules, pathways, and circuits that we're just starting to understand and study. So, it's all pretty exciting."
Greater Good wants to know:
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Jill Suttie, Psy.D., is Greater Good's book review editor and a frequent contributor to the magazine.
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Aberdeen Caledonian Thistle Celtic Dundee Hamilton Academical Hearts Kilmarnock Motherwell Rangers Ross County St Johnstone
Aston Villa Barnsley Birmingham City Blackburn Rovers Brentford Brighton & Hove Albion Bristol City Burton Albion Cardiff City Derby County Fulham Huddersfield Town Ipswich Town Leeds United Newcastle United Norwich City Nottingham Forest Preston North End Queens Park Rangers Reading Rotherham United Sheffield Wednesday Wigan Athletic Wolverhampton
Sheffield Wednesday 1 - Watford 4: Zola thrilled at thumping win
GIANFRANCO ZOLA can remember November with a happy feeling after Watford completed the month unbeaten.
Watford boss Zola said: "That was a very good performance, especially in the second half.
"I'm delighted because in the first half Wednesday had some good spells."
Three goals in the last half-hour from Alex Geijo, sub Troy Deeney and Mark Yeates secured Watford's win after Chris Lines had missed a penalty for the Owls.
Star man Fernando Forestieri had cancelled out Antonio's opener before Watford raced away.


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At the Houston Center for Contemporary Craft, furniture-maker Jim rose shows us his award winning pieces that are inspired by the designs of a 19th century religeous sect and fashioned out of materials he found in a 21st century scrap-metal yard and we hear from author Leann Sweeney about her latest Abey Rose mystery novel, Shoot From The Lip . . .
TFR Producer Bob Stevenson talks with furniture-maker Jim Rose. He's the winner of the 2005 Founder's Prize and the artist whose work is featured in the current exhibition Transformation 5. It's currently on view at the Houston Center for Contemporary Craft. Listen Download
Author Leann Sweeney talks about her novel Shoot From The Lip with KUHF's Catherine Lu. It's the fourth in a series of Abbey Rose mystery novels and is published by Signet. Listen Download


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Dr. Mario 64 Credits (Nintendo 64)
Published by
Developed by
Critic Score
100 point score based on reviews from various critics.
User Score
5 point score based on user ratings.
Dr. Mario 64 Credits
|Executive Producer
|Hiroshi Yamauchi
|Genyo Takeda, Takehiro Izushi
|Hitoshi Yamagami, Yoshiyuki Kato
|Assistant Director
|Atsushi Tejima
|Main Program
|Yasunori Kobayashi, Kazunori Haseguwa
|Art Director
|Toyō Ashida
|Graphic Design
|Akio Saito, Yohei Fujigawa, Shinichi Takehiro, Takehiro Ishikawa, Nozomi Kawai, Tomoki Oda, Toshiyuki Matsuda, Yukio Tanaka, Toyohide Andō, Taichi Sasaki, Takatoshi Anbe, Tomoaki Yamaguchi
|Character Design
|Yukio Ebisawa, Toyō Ashida, Hiroshi Takeuchi, Ayako Kurada, Hatsue Koizumi
|Sound Composition
|Seichi Tokunaga, Manabu Fujiki
|Product Debug & Testing Unit
|Super Mario Club
|North American Localization
|William Trinen, Tim O'Leary, Jeff Miller, Leslie Swan
|Special Thanks
|Masao Yamamoto, Sakae Yamazaki, Minoru Arakawa
Other Games
In addition to this game, the following people are listed as working on other games. No more than 25 people are listed here, even if there are more than 25 people who have also worked on other games.
Jeff Miller, 155 other games
Leslie Swan, 150 other games
Hiroshi Yamauchi, 128 other games
William Trinen, 116 other games
Hitoshi Yamagami, 93 other games
Tim O'Leary, 70 other games
Minoru Arakawa, 61 other games
Takehiro Izushi, 56 other games
Masao Yamamoto, 28 other games
Hiroshi Takeuchi, 20 other games
Atsushi Tejima, 16 other games
Sakae Yamazaki, 10 other games
Manabu Fujiki, 10 other games
Genyo Takeda, 10 other games
Yoshiyuki Kato, 4 other games
Toshiyuki Matsuda, 4 other games
Tomoki Oda, 4 other games
Toyohide Andō, 3 other games
Toyō Ashida, 3 other games
People who have worked on this game have also collaborated on the creation of the following games:
F-Zero: Maximum Velocity, a group of 10 people
Paper Mario, a group of 7 people
Advance Wars, a group of 7 people
Guilty Gear X2: The Midnight Carnival #Reload, a group of 7 people
Super Smash Bros.: Melee, a group of 6 people
Mario Party 3, a group of 6 people
Mario Tennis, a group of 6 people
Pokémon Puzzle Challenge, a group of 6 people
Golden Sun, a group of 6 people
Fire Emblem, a group of 6 people
Kirby Tilt 'n' Tumble, a group of 6 people
Mario Tennis, a group of 6 people
Mario Kart: Super Circuit, a group of 6 people
Game & Watch Gallery 4, a group of 6 people
WarioWare, Inc.: Mega Microgame$!, a group of 5 people
The Legend of Zelda: Majora's Mask, a group of 5 people
Metroid Fusion, a group of 5 people
Advance Wars 2: Black Hole Rising, a group of 5 people
Pokémon Puzzle League, a group of 5 people
Fire Emblem: The Sacred Stones, a group of 5 people
Advance Wars: Dual Strike, a group of 5 people
Fire Emblem: Radiant Dawn, a group of 5 people
Fire Emblem: Path of Radiance, a group of 5 people
Tetris DS, a group of 5 people
F-Zero: GP Legend, a group of 5 people
Credits for this game were contributed by TReMMoR (335)


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Kamal Haasan plays ten characters in ' Dasavatharam '
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Chennai, Apr 28, 20087 : India's southern superstar Kamal Haasan is all set to don the role of ten different characters in his forthcoming film 'Dasavatharam' meaning Ten Incarnations. Regarding the film, Haasan said that 'Dasavathaaram' was one of his most ambitious projects. Besides acting, Kamal Haasan has also written the story, screenplay and the dialogues for the film. Bollywood super star Amitabh Bachchan also congratulated Kamal Haasan on his Herculean effort.
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GBP/USD: the Pound has corrected
On yesterday's session the Bears attempted the resumption of downtrend. The negative sentiment supported by a dead cross and a falling cloud. But the oversold market is not allowed for sellers to update the lows of a last week. A falling has stopped in the area of 1.2850 and the market has began correction in the direction of the clouds.
At this morning we're seeing testing the lower bounds of the Ichimoku cloud. We expect a downward rebounding from Senkou Span A.
Technical levels: support – 1.2970; resistance – 1.3100.
Trade recommendations:
1. Sell — 1.3100; SL — 1.3120; TP1 — 1.3000; TP2 — 1.2970.