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***This shop has been compensated by Collective Bias, Inc. and its advertiser. Readers must be 18 years of age or older. All opinions are mine alone. #bluForYou #CollectiveBias****
I have tried a few 'e-cigs' and vaping products since they first hit the market. There are so many products around that the market can seem; to the new user very confusing.
Basically there are two different types - the type where the nicotine and flavour is in an encapsulated 'filter cartridge' that screws onto the battery and the type that takes a liquid into a 'tank' chamber.
I have had issues with the tank version where you have to tip it upside down to fill it can cause issues - specifically leaking and mess, also it can damage your product if you accidentally put liquid down inside the central chamber!
I've followed blu on Twitter for some time, I like the feed, concept and the design. The products look stylish and at long last I have the opportunity and the inclination to try a product out!
I decided to opt for the liquid version - which come in 5 delicious flavours:
Blueberry, Cherry, Menthol, Mint and Tobacco
at 5.99 each
The really great design benefit is that you load your liquid from the top = NO mess! Instant plus from me plus the fact the battery is really long lasting and the hit you have to have at the back of the throat, - well it is just a win win all 'round!
The blu PRO kit is a really reasonable 19.99 and looks awesome with its sleek black body and the blu signature LED it has a very cool aura about it. It comes as standard with a bottle of tobacco flavour liquid (10ml 1.8% Nicotine) and a blu micro USB charger.
Ordering couldn't be simpler the whole process took me minutes and it was delivered within 48hrs so the service was super quick and just really simple!
As you can see from the pics; the website is clear and crisp. It is instructional, fast & easy to use.
There is an option of registering or quick guest checkout. Shipping is free on all orders over £35.
A really good option is the Auto Shipping which you can use to deliver your liquid weekly so you never run out!
I also don't feel uncomfortable using it in public, unlike actual smoking - which instantly makes you a pariah! Gone will be the days of standing outside in the rain! So more quality time with your family - it is just a win win all around!
You also NEVER need a lighter EVER again!
My favourite things about the product are that you fill it from the top. The blu LED lights, Ultra smooth feel to the unit, realistic throat hit.
As you can see from my unboxing it is compact and practical to carry around:
I used it today during lunch and had no strange looks, no comments and felt relaxed and at ease. I will say though it will take me a few days to get used to holding it as in this pic I think I look like I'm playing the flute!
I am however thrilled with my blu* and can't wait to try other flavours! Smoking really has grown up.
- Twitter: @blucigsUK
- Facebook: facebook.com/blucigsuk
- Instagram: @blucigsUK
Song for this POST


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Mp3 Attack
Why is everyone on the subway listening to Mp3 players? Okay... Now why are they coming at me with headphones??
I put my token in the machine and step through the metal doors of the subway. Grabbing a newspaper from under my arm, I sit down on a red plastic seat.
I scan through the paper. Tragedy, tragedy, tragedy. That's all the newspapers seem to write about these days. Without reading the last page, I place it on the seat next to me.
Tapping my foot, I observe the people around me.
My foot stops. Eyes widening, I realize something strange going on.
Everyone's wearing headphones.
As if they knew my sudden realization just occured, all heads turn towards me. Like one big body, the whole crowd stands up at once and closes in on me. Ear bud headphones are shoved into my ears and electronic music fills my mind.
As I glance at the last page of my newspaper, It seems to say, "Stupid girl."
Because smack in the middle, in black letters of sure death, a headline reads:
Now I'm omnipresent, waiting for your urge to turn on your music.

subset: commoncrawl


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Will rising home prices spur an increase in buying activity from Canadians and other foreigners looking to grab bargains in the U.S. while the grabbing is still good?
Some real estate experts think so — at least in markets such as Florida, Arizona, Texas and Southern California that foreign buyers have long favored.
Apparent bargains are still available in these states. But from rock bottom in recent years, prices are rising as the housing market recovers. This could give foreign buyers an incentive to buy homes now.
Much of the activity is expected to come from Canadians, long the largest single group of foreign purchasers of U.S. residences.
Canadians accounted for 24% of U.S. home sales to foreigners in the year ended in March, according to a report out last month from the National Association of Realtors. China ranked No. 2 at 11%.
A couple factors might spur Canadians to rev up their buying. First, the Canadian dollar is strong, worth $1.019 U.S. dollars. Second, the difference between home prices in Canada and U.S. this year is at its highest in decades, data from BMO Capital Markets show.
Trade group data show that Canadian homes sold for an average price of $350,192 (Canadian) in August.
The median U.S. home price in August was $187,400, according to NAR.
"As the (U.S.) market bottoms and prices edge up, you're more likely to see more activity from foreign and Canadian buyers," said Sherry Cooper, chief economist at BMO Financial Group. "The strength of the Canadian dollar vs. the U.S. dollar has been another big incentive for Canadian buyers."
Canadians are especially partial to Florida and Arizona, says Jed Smith, a NAR economist.
"They buy for vacation purposes and like to have a place in the sun," he said.
Florida, Arizona, California and Texas account for more than half of all foreigner home purchases, the NAR says.
Besides Canada and China, large numbers of U.S. homebuyers come from Mexico, India and the U.K. These five nations accounted for 55% of international buying.
Most Chinese buyers purchase on the West Coast, Smith says. Those from India and the U.K. tend to buy on the East Coast. Mexicans buy more homes in Texas than anywhere else.
Canadians split along geographic lines. Those from eastern Canada favor Florida, while those from western Canada buy in Arizona.
In Arizona, activity from Canadian buyers has been heavy for several years, says Diane Olson, a real estate agent with United Brokers Group in the Phoenix area. Just about all of her business comes from Canadians, most of whom hail from western provinces.
"Canadians have really made an impact in this market because the Canadian dollar is pretty much at par with the U.S. dollar, and U.S. prices have come down," she said. "People are coming in with cash, which also helps, since you don't have the hurdles you face with financing. When the (Canadian) dollar is high and prices are low, it's very enticing."
Meanwhile, BMO's Cooper says her real estate contacts in Florida tell her that foreign purchases have "increased sharply" in recent months, and that "Canadians are the No. 1 component of that."
Cooper also says real estate agents in "sun and sand" states such as Florida, Arizona and Nevada are aggressively targeting Canadians through direct mail, email and newspaper ads.
The push coincides with rising home sales and prices here.
Last week NAR said sales of previously occupied homes rose 7.8% in August from July, to a seasonally adjusted annual rate of 4.82 million — the highest level since May 2010. Meanwhile, the Commerce Department said construction of homes and apartments rose 2.3% to a seasonally adjusted annual rate of 750,000 in August.
Although NAR reported the median home price was down slightly in August from July, it still represented a 9.5% increase from August 2011 — the biggest year-over-year price increase since January 2006.
The S&P/Case-Shiller U.S. National Home Price Index showed all three of its headline indexes ended the second quarter with positive annual growth for the first time since the summer of 2010. The national price index rose 1.2% year over year, while the 10- and 20-city composite indexes in June showed annual growth of 0.1% and 0.5%, respectively.
Cities in Arizona and Florida did particularly well. Phoenix logged a 13.9% year-over-year gain to lead all cities in the 20-city composite. Miami prices rose 4.4%, while Tampa's increased 3.4%.
Rising prices might create a greater sense of urgency among consumers both in the U.S. and abroad to buy homes, Cooper says.
"As long as they think prices are still falling, they are in no hurry to buy," she said. "But when they think prices are turning around, they will be in more of a hurry."
As more foreign buyers gobble up homes, the purchases have a ripple effect on local markets. Phoenix area real estate agent Olson says she has received a growing number of calls from local sellers because they know she does business with Canadian buyers who pay in cash.
Cash Is King
"It makes a big difference when you have people paying cash for homes," Olson said. "People who had been sitting on the sidelines are now willing to put their homes up on the market."
But while an increase in international buyers might bolster key markets in sun and sand states, it probably won't do much to move the needle in the U.S. market as a whole.
Only about 2.5% to 3% of overall buying activity comes from foreign buyers of vacation and investment homes, the NAR's Smith says. Another 2% to 2.5% comes from foreign buyers who are moving here.
Those percentages don't change a great deal from year to year, Smith says, although they fluctuate month to month.
NAR data show a general decline in the share of U.S. transactions by nonresident foreigners since March 2011, when the percentage hit a three-year peak of about 3.7% of overall transactions. In August, that percentage was 1.75%. Some observers say purchases by Canadians tend to dry up in the summer.
Smith expects the figure to return to normal levels in coming months.
"As we see the housing market go up, and as foreign currencies go up, we will move back to 2.5% to 3% of the overall U.S. housing market," he said.
In terms of dollar value, foreign buyers of nonresident vacation or investment homes typically account for about 4% to 5% of the U.S. total. Foreign buyers who are moving here account for another 4% to 5%.
One reason the dollar value is higher as a share of the total is that foreign buyers tend to go after more expensive properties than typical U.S. buyers, Smith says. More than 60% pay in cash.
"We have many multimillionaires moving into southern Florida buying trophy properties," he said.
Big-Ticket Purchases
NAR estimates the total U.S. home market at $928.2 billion for the 12 months ended in March 2012. International sales during that period are estimated at $82.5 billion, or just under 9%.
Still, that dollar value represented a 24% jump from the $66.4 billion in foreign sales for the 12 months ended in March 2011.
"There was a significant increase in the price of the houses during that time, and (foreign) purchasers went more upscale," Smith said. The increase "just tells you that more money is being spent.
"I think it shows that during that time frame the foreign currencies had a little more value," Smith added. "Many international markets were also in turmoil, so the U.S. was a good place to put your money."
NAR data show that 26% of international home sales in the U.S. are located in Florida. Other leading states are California, at 11% of the international total; Texas, 7%; and Arizona, 7%.
Gradual Growth Seen
Smith doesn't expect international sales to have a huge impact on the overall housing market, though he does figure the share will grow, if only slightly, in coming years.
"What we will see is a gradual increase of purchases by foreigners in this country," Smith said. "They buy here for a number of reasons: They want a second home, or to earn a profit and to diversify their assets.
"As foreigners become increasingly wealthy, we will see a little bit more of that. But I don't think you'll see it become a major market here."


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All reader reviews by Big Al
Pizza Paradiso
I had a meal with two friends at this restaurant on a Wednesday evening (10/01/07).
The Staff were very polite the meal was very tasty and the profitiroles were fantastic.
Friday, January 26, 2007
Overall rating
Food 9 | Service 9 | Atmosphere 9 | Value for money 9


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Prominent legal and police figures have derided the proposal as ineffective and political demagoguery.
The Attorney-General, Janet Reno, has voiced fears about such a blanket response to frequent offenders, and in Congress, some black Democrats have tentatively raised civil rights concerns.
Several versions of the 'three strikes' provision are under consideration but, in essence, anyone found guilty of a committing a violent, federal offence, who has been convicted of two previous crimes, not necessarily violent in nature, would be incarcerated for good.
By embracing such a proposal, Mr Clinton deliberately identified himself with the hard-line conservative school on combating crime.
He is not only following the popular trend - crime is overtaking the economy as the main object of anxiety among Americans - but is also stealing some thunder from the Republicans.
That the response from liberals within the President's own party has been so muted is testament to the strength of public support. Momentum behind the 'three strikes' provision seems unstoppable, and no fewer than 30 states are considering introducing such legislation.
It did not go unnoticed, however, that while both sides of the chamber gave a standing ovation to the proposal, members of the congressional black caucus remained seated. Before his speech, caucus members wrote to the President asking him to 'blend the need for certain and severe punishment for today's most serious offenders with the need for compassion and community-building'.
The black New York Democrat Charles Rangel fears that 'small-time punks, mixed-up kids' could be ensnared. And similar worries have been raised by the American Civil Liberties Union, which is leading opposition to the provision.
Eric Sterling of the Criminal Justice Policy Foundation dismisses the measures as 'a vote-getting, headline-getting policy'. 'This provision, instead of targeting rapists, armed robbers or serial killers, will send to prison for life the punk who has a fight outside a bar after his team loses the Super Bowl, the drug-addict burglar and a host of penny-ante offenders.'Reuse content


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flexplate torque
What is the correct torque to install my flexplate, and should I use a star washer or is the red loctite good enough?, also what is the proper torque to install my torque converter? Thanks, Dana
I used locktite on mine (forgot which color) and it worked, I could not tighten them to stay on and that was my answer.
The converter will click twice pushing it on.
Use this site, it has about all the Chevy torque specs:
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This gorgeous 3 bedroom + finished room above the garage boasts with tons of features! The living room has high ceilings and a cozy fireplace. The master suite is amazing with two huge walk in closets, dual separate vanities, separate shower and a whirlpool tub! Head outside through the relaxing screened porch and in to the neatly landscaped backyard with a privacy fence and shed for extra storage. Added extra protection with a security system installed as well as a six switch portable generator system wired throughout! Make an appt to see this home today- you won't be disappointed!


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When Sebastian Faulks first published Birdsong, it was met with a muted reception. The year was 1993 and it was not exactly fashionable to be writing about the things that the novel describes so viscerally: the battle of the Somme, the terror of the trenches, the claustrophobic terror of the tunnels beneath those trenches, and the assault on the souls and spirits of the men who saw wave after wave of slaughter on the battlefields of the Great War.
Not many others were looking back to 1914 at the time. Pat Barker had written the second of her Regeneration trilogy, and Helen Dunmore was soon to give us Zennor in Darkness (1994) when Faulks put out his contribution, but by and large, it was perhaps assumed that stories of the First World War had been told. When Birdsong was published, it got scant attention, Faulks recounted some years ago. "I see from diary that I did my sole interview at 2pm that day on a local radio station; I also did an interview with the London Evening Standard, but it appeared only in the racing edition, under the headline 'Does this look the sort of man to write a book to make you feel sick?'".
Now, 21 years after its publication (and 3 million copies sold) 100 years after the start of the war, six weeks before hostilities began in 1914, it seems as if we've begun to tell the untold stories in fiction and in history, yet for some, the questions that Birdsong posed remain to be answered; so when it drew our eye to the profligate waste of young life, asking obliquely, whether it was worth it, and when protagonist, Stephen Wraysford, grappled with his dismay over policies delivered to the trenches from Westminster: "This is not a war, this is an exploration of how far men can be degraded." The question of whether it was better to die than to live was also one that preoccupied many characters in the light of witnessing death, and such despicable, violent death.
Among the recent plethora of Great War fictions, we will soon see the re-publication of Birdsong, and with it, another question posed by Faulks that hangs in the air. In a collection of writings from the war, A Broken World, which he has co-edited with Hope Wolf, he says that the bigger questions have remain unanswered. "To me the greatest of these is as follows. Did Europe's enthusiastic discovery of genocide in 1914-18 make a mockery of the preceding five hundred years, rendering such terms as the 'the Renaissance' and 'the Enlightenment' simple self-delusion; and if this war showed the true nature of the human creature, its limitless capacity for killing once the means are in its hands, how are we to deal with our revised knowledge of what we are?"
The latter question resounds across the century, from the atomic bombing of Nagaski and Hiroshima to chemical warfare in Syria, but it is a moot point whether the discovery of this barbaric aspect of human nature was made in the Great War. Didn't we know this side of ourselves, long before 1914, though we might not yet have had aerial and machine-gun weaponry at our disposal? I will be in discussion with Faulks this Saturday evening, at Foyles, in London, about Birdsong, so I suppose I can ask him this myself. The mode of battle may have changed in 1914 but the savagery was already there, especially in the colonies where many of the new weaponry was being tested against a far weaker "enemy". Some of the questions that Faulks mentions are beginning to be asked publicly. But perhaps there are some questions about human nature and its capacity for destruction that will always remain unanswerable.Reuse content


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Dennis, Anyone?
Were ready to move on. Honest. We wont mention "his" name again because, like a bad relationship, weve had time to forget him. Instead, well swoon over the new man in our pigskin lives, a dude that aint all talk and no action like some ex-field generals we know.
Were talking about new ASU Sun Devils football coach Dennis Erickson. The Erickson who led the Miami Hurricanes to two national championships and put the bite back in the Beavs at Oregon State. A proven winner who has, in his corner, eight home games -- marquee matchups include a Turkey Day showdown with preseason No. 1 USC and an early-December Territorial Cup game versus the Tucson Mildcats -- and a five-deep running-back corps that may just be the best in the nation. Aw, we think were already in love.
The Devils open the ´07 season and a four-game home stand against the San Jose State Spartans, not a cupcake by any means, especially because they're led by a familiar nemesis in ex-UofA trickster Dick Tomey.
Sat., Sept. 1, 7 p.m.
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RENNtech Downpipes are constructed from T304 High-Strength Stainless Steel and are equipped with 200 Cell Sport Catalytic Converters.
With the replacement of the stock downpipes we improve performance, reduce back pressure, increase initial turbo spooling and enhance sound output.
RENNtech products are manufactured to perfectly match the stock C 63 AMG exhaust system, as well as the RENNtech Sport Muffler System and include all necessary mounting hardware and clamps.
Our downpipes are designed and manufactured at the RENNtech Headquarters in Stuart, Florida.


text: The U.S. Department of Labor (DOL), offers a resource called eLaws Advisors, to help employers and employees understand the many federal employment laws. The website is actually more of an interactive tool that guides users through a series of question to provide specific information relevant to their particular circumstances. There are eLaws Advisors on wage and overtime issues, workplace poster requirements, health benefits, federal contractor compliance, and other topics.


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TRUSTe is yet another must have alternative party endorsement of the website�s persistence for protecting your important information. However, it is also clear that getting national certification through PTCB can help your career. People may think about using homeopathic treatments just since they're quite low-cost.
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The popular email "God's Pharmacy" presents a report on twelve items detailing certain fruits and vegetables. Progression and cancer risk factors can therefore be safely assumed for similar conditions existing in NSCLC. Their recommendations about medicines and dosages needs to get adopted on, that they can need to become acquainted with medicines and that's consequences.
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Morris Arboretum of the University of Pennsylvania
- 100 E Northwestern Ave
- Philadelphia, PA 19118
- (215) 247-5777 Ext. 121
Offering a variety of room set ups for daytime meeting. Audio-visual equipment and LCD projector available. Food service available for 15 or more. Or choose an outdoor setting with access to the grounds and carriage house.
- Booking Notes: Guided golf cart tours for people with physical disabilities must be scheduled in advance.
- Credit Cards Accepted:
- Days & Hours of Operation: Open every day 10am - 4pm, except for the following holidays: New Years Day, Thanksgiving, Christmas Eve, and Christmas Day.
- Public Restroom(s):
- Seasonal Days & Hours of Operation: April - October weekends until 5pm. June - August Wednesdays open until 8pm. Weather emergencies may require us to close the garden or limit access to some garden features.
Group Tours
- Guided Tour - Min/Max Size: Group Rates for 10 or more people.
Guided Tour for Groups:
- Both
- Motorcoach Parking:
- Description Our facility offers a variety of room combinations and set ups available for daytime meeting rentals, from 9am until 4pm. Our Meeting Rental rates are effective Monday through Friday only. Quality audio-visual equipment is provided for your use, and we can offer an LCD projector available for additional fee. Food service is available for clients bringing 15 or more guests. Rental facilities are located in the Widener Visitor Center, a restored Victorian carriage house. Garden Rentals are available for special events from 6pm-11:30pm, Monday through Thursday. Weddings are not offered during this time.
- Space Notes 175 is the maximum that can comfortably be seated in our tented reception area attached to the Widener Visitor Center carriage house. Within the Widener Visitor Center, the Upper Gallery can accommodate 65.
- Preferred vendors
McLean Room
- Classroom Capacity: 12
Gates Hall Conference Room
- Classroom Capacity: 13
Upper Gallery
- Theater Capacity: 80
- Banquet Capacity: 64
Side Tent
- Theater Capacity: 50
- Classroom Capacity: 22
Widener Visitors Center
- Banquet Capacity: 175


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Human SOCS2 Primary Antibody for AP, AA - ABIN1320927
Sen, Peng, Woods, Wistuba, Bell, El-Naggar, Lai, Johnson: STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
The upregulation of SOCS-1 (show SOCS1 Proteins) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
Overexpression of SOCS-2 is associated with hepatocellular carcinoma.
focus on SOCS2 and review its biological function as well as its implication in pathological processes
SOCS2 may improve outcome of TBI (show TBPL1 Proteins) in mice by regulating aspects of the neuroinflammatory response
This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains.
crystals of SOCS2 in complex with its adaptor proteins, Elongin C (show TCEB1 Proteins) and Elongin B (show TCEB2 Proteins), underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.
miR (show MLXIP Proteins)-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression.
our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML (show RUNX1 Proteins).
This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity.
The SOCS2 polymorphism (rs3782415) has an influence on the adult height of children with Turner syndrome and growth hormone (show GH1 Proteins) deficiency after long-term therapy.
SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.
Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin.
Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection.
Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (show GHR Proteins)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (show IGF1 Proteins)) level.
GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (show IGF1 Proteins).
comparison of murine wt and Socs2(-/-) HSC (show FUT1 Proteins) gene expression in response to 5-FU revealed a significant overlap with the molecular programs that correlate with SOCS2 expression in leukemias, particularly with the oncogenic pathways
Studies indicate the critical role of suppressor of cytokine signaling 2 (SOCS2) in ontrolling the local growth hormone (GH (show GH1 Proteins)) anabolic bone effects.
Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 Proteins) signal pathway.
SOCS2 immunoprecipitates with TrkA (show NTRK1 Proteins) and a juxtamembrane motif of TrkA (show NTRK1 Proteins) is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA (show NTRK1 Proteins) expression. SOCS2 regulates neurite outgrowth.
Results show that CISH (show CISH Proteins) has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish (show CISH Proteins) during pregnancy.
SOCS2-mediated feedback regulation of the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway is deficient in BCR (show BCR Proteins)/ABL1 (show ABL1 Proteins)-induced chronic myeloid leukemia (show BCL11A Proteins).
hepatic growth hormone receptor (show GHR Proteins) and suppressor of cytokine signaling (SOCS (show CISH Proteins))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
suppressor of cytokine signaling-2
, suppressor of cytokine signaling 2
, suppressor of cytokine signaling 2 variant 1
, STAT induced STAT inhibitor-2
, STAT-induced STAT inhibitor 2
, STAT-induced STAT inhibitor-2
, cytokine-inducible SH2 protein 2
, cytokine inducible SH2-containing protein 2
, suppressor of cytokine signalling 2


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It's a task each and every one of us are looking forward to, and with senior leaders on the offensive side of the ball -- guys like Alex Brink, Michael Bumpus, Bobby Byrd, Charles Dillon and Jed Collins -- I feel we are very capable of having an excellent season.
Each one of those men, in preparation for the upcoming season, stayed in Pullman during our four week summer vacation in May. They have invested over four years of blood, sweat, and tears into Cougar football, and I feel it is only fair to send them off as victors. I am proud to say that I go into battle beside them on Saturdays.
As many Cougar fans know, the offense got pretty scrappy during spring ball because of injuries, but it also allowed many of the younger guys to step up and create depth for the upcoming season. My high school coach used to preach you are only "a sprained ankle away from being a starter." And because of that, each Cougar player must be prepared to play at anytime.
Time to talk about the big boys down in the trenches.
While across the roster you don't see many 315-pound plus type of players like we've had here at WSU in the past, we make up the weight difference with our athleticism. Coach George Yarno is simply the best at what he does -- he doesn't teach us by individual position, he teaches the line how to work together as a whole.
Each one of our guys has the capability of playing four or five positions in any game. Last year, for instance, Kenny Alfred and myself saw time at three different spots, but we were able to make the necessary changes without missing a beat because of the knowledge of the game instilled in us through and through by coach Yarno.
It's exciting to watch the younger guys mature throughout the year. Cougs like Micah Hannam, Vaughn Lesuma, Jake McKinney, Grady Maxwell, Joe Eppele and Scott Friberg have already made huge strides learning the offense -- and once it "clicks" in their minds, it's great to see how quickly everything slows down and becomes easier to understand. I know each one of these guys will be ready when their name is called.
I also wanted to make special mention about the leader on the line, Bobby Byrd.
A four-year starter, he moved back inside to left guard for spring ball and looked very impressive doing it. You can tell Bob's taken this summer to heart. He's worked his tail off, added quickness and dropped some weight off his 6-foot-7 frame -- and take it from me, he's going to be a force to deal with this year. He fits to a tee our focus for this season: "One play at a time, One series at a time, One game at a time."
And not to forget about who is playing next to him at center -- a returning freshman All-American in Kenny Alfred, (Scout.com Freshman AA second team and '07 Rimington Trophy Watch List member), and he's added 10 pounds to his frame and has probably one of the best upsides of any player on the team.
We have the weekend off, and with this heat wave blistering Pullman the last few days, I'm sure many of us will be getting together, catching some sun and then gearing up for the final push before fall camp.
Feel free to post any questions you might have here on the Cougfan.com message boards and I'll answer as many as I can next week. Until then, as always, GO COUGS!!!
Dan Rowlands finished the '07 spring session as WSU's starting right tackle. A versatile lineman who started at both right and left guard last year, the 6-5, 290-pounder will be a fourth-year-junior in 2007. He hails from Seal Beach, Calif., where his senior year he was the top o-lineman for Los Alamitos High, a perennial powerhouse in California's Southern Section. After a redshirt season at WSU in '04, he's played in 22 games the past two years, starting 9 last season. Against UCLA in 2006, he was helped off the field twice with injuries only to return to the line each time, and he started the following week. He graciously volunteered this summer to give CF.C readers an inside look at the world of pre-season football preparations with a weekly diary.


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hey everyone, im new to cyburbia and have been poking around some threads tonight but couldnt quite find an answer to this question. sorry if it has already been discussed!
i have been interested in radical urban planning for a while, but just recently started looking into grad school prospects. it seems most programs have at least some bit of an environmental aspect built into them, but i really want to focus on environmental issues and planning internationally.
in my dream world, for instance, i would work in central and south america, helping create sustainable areas that really foster the idea of community, tradition, etc. i am open to attending grad school abroad, as well, but unfortunately am not fluent enough in any other language to be studying at that level.
i would really appreciate any feedback on schools with good international specialization programs, or any instructors with knowledge in that field with whom i could put together an independent study.
also, as i have no background or experience with planning (ba in anthropology), i have been thinking this spring and summer would be a good time for an internship. that is something i would REALLY like to be able to do abroad, if possible/affordable. does anyone know of a good place to look for an opportunity like that? or have experience with something similar through americorps? (im thinking the grad school stipend will come in handy)


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Crush ten almonds in coffee grinder and mix this powder to yogurt. Make sure that yogurt is natural without any additives. The paste is applied and on the face and left for the twenty minutes. After that wash it off with either cold or warm water.
[Read more…] about Natural Beauty tips for aging gracefully from Ten Countries


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Port of Collingwood to Canada's west.
Oct 3, 2015, from 10 am to 4 pm Tours and displays of artifacts including the rarely seen second floor offices which housed Canada Customs and Transport Canada Shipping offices and the caretakers quarters. View the amazing architecture and stained glass ceiling and windows and more.
As well on display will be memorabilia of the RCMP and models of ships which carried the first NWMP officers (later renamed the RCMP) who sailed from Collingwood in Oct 1873 to Canada's west.
Be sure to be a part of one of Canada's most historic events. Hosted by the Collingwood and District Historical Society.


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Get in-depth analysis of current trends in the legal community, profiles of fascinating professionals, academic issues and lifestyle discussions for law school students, and a few out-of-the-ordinary goings on in the world delivered to your inbox.
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Charles F. MacKelvie has joined the Chicago office of McDonald Hopkins as a member in its healthcare and healthcare restructuring process. MacKelvie...
Summary: There are endless reasons as to why attorneys are risking their jobs at law firms, often without even realizing it. Here are just 10 reasons. Were you aware that there are hidden dangers that jeopardize your current job or […]
2017 State of the Lateral Law Firm Market


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MEMBERS of an alleged sex gang threatened to kill a young victim — telling
her: "You know what we do with pigs? Slit their throats," a court heard
Nine men stand accused at the Old Bailey of charges including raping,
torturing and pimping out six vulnerable underage girls who were plied with
booze and drugs.
They are said to have subjected the 11 to 15-year-olds to a "living hell" over
eight years of abuse from 2004.
Some girls allegedly endured sex attacks described as "perverted in the
extreme", which were said to have lasted days.
And one gang member allegedly forced a victim to have a backstreet abortion at
just 13.
The defendants, including two sets of brothers, yesterday faced 51 charges.
The list was so long it took half an hour to read out.
The court heard the alleged abuse took place in Oxford, where all but one of
the men on trial lived and worked.
One victim was driven to woods at night after lying to gang members in a bid
to escape abuse, the court heard.
Prosecutor Noel Lucas QC said: "They threatened her, saying, 'You know what we
do with pigs? Slit their throats'.
"Another car then turned up containing four other men. They threatened to cut
her head off."
The girl was told she would only be spared if she performed sex acts, it was
said. She and other victims were plied with alcohol plus cannabis, cocaine
and even heroin so they couldn't escape, it was claimed.
Some were used as prostitutes and the gang took the cash, it was said. Victims
were told they and their families would be targeted if they fled.
Mr Lucas told jurors: "The depravity of what was done to the complainants was
"Much of what the girls were forced to endure was perverted in the extreme."
Anjum Dogar, 30, brother Akhtar, 32, Kamar Jamil, 27, Mohammed Karrar, 38, his
brother Bassam, 33, Assad Hussain, 32, Mohammed Hussain, 24, Bilal Ahmed,
26, and Zeeshan Ahmed, 27, deny charges including rape, arranging child
The trial, which is expected to last three months, continues.


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Shanghai Olympic Stadium is the second-largest (just after the Beijing National Stadium) in scale stadium with the most advanced facilities in China. The stadium will host for football preliminaries in Beijing Olympics 2008. It meets all the functional and technical requirements of an Olympic National Stadium: the world's longest cantilevered steel truss roof structure with fabric canopy and span of 300 meters; design as per the directives of International Olympic Committee (IOC). The stands, with 80,000 seat capacity, evoke the image of a bowl. The shanghai Olympic Stadium is used for Football Preliminary rounds of the 2008 Olympic.
Solo Adventure Tips:
In Xujiahui District of Shanghai
How to Get There?
Take Shanghai Metro Line 4 to the Shanghai Stadium station
Ticket Price:
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Information accuracy:
We try to make the information on China Travel accurate when we write/edit it. If you find any outdated information, please inform us.


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a novel (1910) by E M Forster. It describes the relationships between two very different middle-class families in Edwardian England. Howards End is the name of the house in which one of the families lives. There was a film version by James Ivory in 1992.jump to other results
Howards End
BrE ; NAmE
Check pronunciation: Howards End


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|Reviews for Coppercurls
| Purple Majestic chapter 7 . 10/8/2015
This s such an exciting start! I look forward to reading more!
| anon chapter 7 . 9/25/2015
Yayy an update!
Some fixes:
bauble bubble, lightening lightning, snap-ish snappish
| Trisbriarock chapter 6 . 6/25/2014
Pls continue
| cdg12 chapter 6 . 11/11/2012
Sorry, I'm new to the Circle world and only read the series a few months ago, thats why i'm commenting now.
Your ideas are great! I mean using Keth's globes again!
| Andy chapter 6 . 7/13/2012
First congrats on your marriage and big move. And now FINISH. I always wanted Briar and Tris to get together and I love Tris anyways because she is just awesome. I like her entire story including Keth and now I need to know what is gonna happen. This is really good so hurry, hurry, hurry. Please! :D
| SpangleyPony chapter 6 . 2/1/2012
glad your back. Congrats on your marriage. Where did you move to? I'm surprised you have an inclination to write after all that :-)
| AzurexJen S chapter 5 . 5/29/2010
I'm too curious! PLEASE UPDATE! XO plz plz plz plz plz plz plz plzplzplzplzplzplzplzplzplz!
| AzurexJen S chapter 4 . 5/29/2010
Poor Tris, being stuck with two cute boys while heartbroken. A shame really.
Is it just me or do/did other people feel like smacking Berenene over the head while reading this story and/or The Will of The Empress?
| SpangleyPony chapter 5 . 11/30/2009
I'd actually forgotten about this story, I hope you can update soon.
| L.A.H.H chapter 5 . 11/29/2009
Update again sooner please! This chapter was very good, and interesting. I'm looking forward to more. x
| queenofspades19 chapter 5 . 11/29/2009
Something tells me Keth isn't going to help as much as hurt.
| crossxavier chapter 4 . 8/5/2009
A surprising addition there at the end of the chapter to be sure. I truthfully didn't see that one coming. The story seems to be progressing smoothly so far. You managed to get me curious about a few things so I'll just list them as they are various questions that cross my mind as I read and by no means do you have to answer them. They are just for input so if they bore you too much feel free to skip them. Are exhaustion and fatigue the only symptoms of the disease (it seems fever at least should be added) or did the Duke just not have a chance to say other symptoms? Is this a disease brought on by normal means or by magic (or could it just be a curse made by a mage)? Are Briar, Tris, and the others not even the least bit suspicious about the letter from Berenene or is it just because of the situation that they aren't thinking too coherently? Where are Tris and Briar when Keth meets up with them (I believe he was working in the far borders of Namorn in the city he originally met Tris at) and is meeting him a coincidence or did he seek them out for some reason? Enough with the questions and on to some other things on the story. The misunderstanding between Briar and Tris is quite heartbreaking but creates the drama and just makes the story that much more entertaining to read. It was interesting to see Briar go all jealous and protective when Stormbringer caught Tris as I actually think it fits his character quite well. One suggestion that is a bit nit-picky to be sure but thought I'd point it out. In this chapter (chapter 4) after Briar reads the letter from Berenene you have him referring to Tris as "Trisana" which I don't think I've ever even heard other people call her besides Crane and a few nobles. It is most definitely not something major so by no means should you change it if you think it unnecessary but just thought I'd let you know. Anyway I enjoyed your story thus far and I am looking forward to reading more from you.
| L.A.H.H chapter 4 . 4/21/2009
This was very good! Thanks for writing it so far - please don't leave it here. x
| Em Rose chapter 4 . 4/11/2009
aw i love the tris/briar pairing i think they are perfect for each other! thanks so much for writing this, it's a really good read and I will definitely look out for updates in the future, the story is really shaping up...and scandal with keth?
so exciting! hehe
thanks again, and i'll keep reading!
| Georgina chapter 4 . 4/11/2009
Very well written and please update soon!


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|"Amar Kamat (JIRA)" <j...@apache.org>
|[jira] Commented: (MAPREDUCE-1316) JobTracker holds stale references to retired jobs via speculated tips
|Sat, 19 Dec 2009 09:21:18 GMT
[ https://issues.apache.org/jira/browse/MAPREDUCE-1316?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12792829#action_12792829 ] Amar Kamat commented on MAPREDUCE-1316: --------------------------------------- I think this scenario can be generalized further failed/killed jobs too. Consider the following 1) a job is running and the jobtracker schedules some tasks 2) even before the tasktracker with the newly scheduled task reports back, the job gets killed or is failed because of errors 3) jobtracker goes ahead and launches cleanup task (if any) which also completes before the task-tracker with scheduled tasks report back 4) the job completes and later retires 5) the tracker with newly launched task reports back The jobtracker simply ignores the updates as the job is retired. I think the problem is in general with the tasks that are scheduled but the tasktacker reports only after the job retires. Thoughts? > JobTracker holds stale references to retired jobs via speculated tips > ---------------------------------------------------------------------- > > Key: MAPREDUCE-1316 > URL: https://issues.apache.org/jira/browse/MAPREDUCE-1316 > Project: Hadoop Map/Reduce > Issue Type: Bug > Components: jobtracker > Reporter: Amar Kamat > Assignee: Amar Kamat > > JobTracker fails to remove speculative tasks' mapping from _taskToTIPMap_ if the job finishes and retires before the tracker (running the speculative tasks) reports back. In such cases a stale reference is held to TaskInProgress (and thus JobInProgress) long after the job is gone leading to memory leak. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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Oakland, Berkeley, And East Bay News, Events, Restaurants, Music, & Arts
Whatever safeguards the app needs, don't kill it. A couple of us rode BART Sunday afternoon. At the Embarcadero stop, a gang of several youth in hoodies on a hot day, no more than 14 years old, made two attempts to snatch purses in our crowded car - one of them from the person I was with. The robber gangs do not operate only at Coliseum station, they do not operate only at night. It would be great if someone caught good snaps of these thieves and passed them on to BART - and posted them publicly.
With a surveillance equipment regulation ordinance, aka a comprehensive privay ordinance, BART would have been required to vet this app to the public and say exactly what kind of information it was gathering, to whom it would go to and for how long it would be stored. Based on this information and public input the BART Board could have then decided to go ahead with the app, change some parameters about how it had to operate, or nix it.
This is not a radical idea! It's what oversight and transparency means. The BART board needs to step up and pass the ACLU/Oakland Privacy surveillance equipment regulation ordinance that's been worked on with staff and privacy advocates since last year now.
If you go to:
They have some reports in there, which are full of references of real-world studies from the US and other countries, concerning impaired driving and what not..
There's some good info and the references within...
Also, the www.globaldrugpolicy.org has some good info and cross references.
The Journal of Drug Policy and Practice - Volume 10, issue 3 - fall 2016
Why a 5 ng/ml THC Limit is Bad Public Policy - and the Case for Tandem per se DUID Legislation:
To quote some sections (formatting may be off, sorry)...:
Page 4:
marijuanas THC is unlike alcohol chemically, biologically, and metabolically. As a result, what works for alcohol does not necessarily work for THC. There is no level of THC in blood above which everyone is impaired and below which no one is impaired. This is not due to a lack of research. It is due to chemistry and biology. It is not due to politics. It is due to science.
Neither THC nor alcohol impairs blood, breath, urine, or oral fluid. These drugs impair the brain.
We test for alcohol in blood as a surrogate for testing the brain. Blood tests are very easy, and breath tests are even easier. Testing the brain requires an autopsy which is far less convenient, to say the least. For alcohol, blood is an excellent surrogate because it is a small water soluble molecule that rapidly establishes a concentration equilibrium in highly perfused tissues throughout the body.
For some drugs, especially marijuanas THC that is of great popular concern, blood is a terrible surrogate to learn what is in the brain. That is because THC is not highly soluble in blood. THC prefers fatty tissues like the brain, heart, lungs and liver. THC is quickly removed from the blood stream as it is absorbed into the brain and other fatty organs and tissues. Even though the metabolic half-life of THC is estimated to be over four days, more than 90% of THC is cleared from blood within the first hour after smoking marijuana (Huestis et al. 1992; Toennes et al. 2008). See Figure 1. Furthermore, that clearance rate is so highly variable from one individual to another that retrograde extrapolation to estimate blood levels of THC at a prior time cannot be done reliably, as is commonly done with alcohol.
Page 6:
2. Blood levels of THC are lower than brain levels of THC Mura compared THC levels in blood and in the brain in a series of autopsies. There was more THC in the brain than in the blood in 100% of the subjects. Significant levels of THC were
found in the brain even when none could be detected in the blood (Mura et al. 2005). So even if we knew the blood level of THC at the time of the incident, this would tell us absolutely nothing about the drug level of THC in the brain, the only place where it really Matters.
3. Tolerance results in varying levels of impairment at the same blood level
So even if we knew the drug level in the brain, this tells us nothing about the level of impairment of the individual.
Page 7
4. Polydrug impairment renders individual drug per se levels meaningless Most drug-impaired drivers responsible for vehicular homicide and assault are polydrug users (Wood and Salomonsen-Sautel 2016). That is, they have at least two drugs in their bodies at the same time. Drug combinations act differently than drugs individually, sometimes with additive effects, sometimes with synergistic effects, sometimes with complementary effects.
Page 8
Proving drug impairment The best way to prove drug impairment is to focus on measurements of drug impairment, rather than measurements of drug levels. After all, impairment is what were worried about, not lab tests. Impairment kills and maims people. Unfortunately, impairment measures are more subjective than laboratory tests.
Page 11
England and Wales recently did the same thing by establishing drug per se levels for a panel of drugs using two different criteria. For illegal drugs, such as marijuanas THC, they set the levels based upon laboratories quantification abilities. For THC that was 2 ng/ml. For legal prescription drugs, they set the per se levels based upon impairment levels chosen by a panel of experts.
Drug per se laws Impairment-based Although some variation on zero tolerance is the preferred way of meeting the demands for drug per se levels, Washington, Colorado and Montana have taken the scientifically invalid approach of establishing what they believe are impairment-based per se levels.
By ignoring all drugs other than marijuana, these states suggest a belief that drug-impaired driving is all about marijuana-impaired driving. Nothing could be further from the truth. For example, a court record study of Colorados 2013 vehicular homicides and vehicular assaults due to DUI revealed that at least 30%, or 51 of those cases, involved drugs. Yet only three of those cases identified marijuana as the sole intoxicant. The other 48 cases involved other drugs or more commonly combinations of drugs, the most common of which was alcohol combined with marijuana (Wood & Salomonsen-Sautel, 2016).
Colorado, Washington and Montana ignore the chemical, biological, and metabolic differences between drugs and alcohol. They ignore the fact that scientific evidence does not support impairment-based per se blood levels of drugs.
Page 13
Fallacies from 5 ng/ml THC supporters
Colorados 5 ng/ml compromise satisfied neither the public safety constituency nor the marijuana lobby.
Only the following constituencies benefit from this poor compromise of 5 ng/ml limit:
1. THC-impaired drivers who test below 5 ng/ml
2. Legislators who can convince poorly educated constituents that they did something to
address the problem of marijuana-impaired driving.
3. In a 5 ng/ml per se state, prosecutors benefit by being able to notch prosecution victories without needing to prove impairment.
Although 5 ng/ml was certainly a compromise, only a handful can claim it was a good compromise.
Page 16
Conclusion Autopilot mentalities and a lack of scientific understanding have caused many state legislators to support scientifically-invalid 5 ng/ml THC per se laws. Impairment by other drugs is thereby ignored, as is polydrug abuse...
Page 17
The American Automobile Association concluded, The data do not support science-based per se limits for THC (Logan, 2016).
50yrs ago? What does that have to do with today? It costs $2 for a bus ticket. And parks in slums will not bring in business, so how do you expect a city to survive? Welfare checks?
Institutional racism? Awww... Pretty bird. Yes, can you say pretty bird? Pretty bird, yeah pretty bird...Hobart want a cracker?
As I recall the Bay Area chapter of an environmental organization instituted a program to get minority children to local natural areas. This was 50 years ago in San Francisco where it was established that many impoverished kids in S.F. had never seen the Pacific Ocean.
The redlining and institutional racism continues in "diverse" and oh-so-sensitive Oakland. Instead of devoting bayside parcels to parks and other open spaces for the children who live in poor neighborhoods nearby, Oakland is fostering fancy high-rise developments for the affluent.
The outlook of the privileged class doesn't change so the living conditions of the poorest never get better.
The Nazi George Rockwell has plenty of allies in Oakland's city hall, whether they are conscious of it or not.
As always, if there's not enough crime, law enforcement will invent crime. That's what the war on drugs is for.
Christopher Fallis
Oakland, CA
i have a? i have 2 Mothers 4 foot tall ( for cloning before they went outside ) they look good and they flowering like crazy! i cannot do light deprevation is that may be harvest in july? yor opinion appriciated thank you
Yes, lack of green spaces and not laziness and sodium rich diets is the contributing factor to health problems for non-whites.
I know of a couple large land masses where there is plenty of green spaces. I hear the cost of living is quite cheap too!
The article mentions hogs apothecary as good for the neighborhood but neglected the fact that the owner of hogs steals from his employees by forbidding them from taking legally mandated breaks. This is actually extremely bad for the neighborhood and the workers.
Additional resources:
Denise Valenti
Like all the junk science pushing the idea of marijuana impairment, your "studies" only say a certain percentage of drivers in accidents tested positive for marijuana.
That says NOTHING about impairment or the actual cause of the accidents - just that a some were marijuana consumers. - What actually happened in those accidents was some unfortunate NON-impaired marijuana consumers were crashed into by drunk, texting, or otherwise REALLY impaired drivers.
The preponderance of the legitimate studies actually looking at impairment (like the National Highway Traffic Safety Administration research of 2015 cited below) show that marijuana is NOT a significant cause of auto accidents.
Shame on you for pushing this deceptive propaganda.
Levels of active THC, inactive THC and CBD or any combination are not enough to determine functional impairment to drive. Consumer tests such as DRUID and MyCanary are excellent tools to raise awareness within the marijuana consuming community about their individual response and impairment with marijuana use.
It is SOOOO biased, uneducated and reactionary to make the assumption that any person concerned with marijuana and public safety (including driving) are not in favor of legal adult use of marijuana. It is not safe to drive after marijuana use. Data in all states with recreational use are suffering with an increase in harm and death.
The data is indicating that one of the more tragic outcome of legal and potentially the medicinal use of marijuana are more drivers using marijuana and driving under the influence. The state of Washington recognized this and worked with private agencies to survey the crash and fatality rates. What is clear is that the fatality rate specific to cannabis has increased.
Another chilling statistic: Those testing positive for marijuana alone, not alcohol or other drugs, are FIVE TIMES more likely to kill someone other than themselves compared to a driver testing positive for alcohol.
Tests of function are desperately needed so as to obtain convictions and remove these dangerous drivers from the road. IMMAD - Impairment Measurement Marijuana and driving is a simple app for a tablet that objectively measures functional impairment. It measures the visual field deficits (HUGE BLIND SPOTS or TUNNEL VISION) that occurs with marijuana use. Marijuana has been shown to significantly impair the eye retinal ganglion cells. IMMAD - Impairment Measurement Marijuana and Driving, measures this. IMMAD and other tests of function need further development and studied so as to have better tools for law enforcement to use in dealing with marijuana impaired driving.
So Glad he's finally being charged. Illegally evicted me, lied in court. This man deserves to rot in hell
He's an cold hearted human who deserves to be locked up in the Pen. He kept boosting our rent from $1200 to 1,650 in three months with no fixing any of our carpets, lights or doors. Finally came and fixed it after 9 months of begging!!! He deserves to get locked up. There are poor elderly people who lives in his other property who went from 1,000 to 2,800 on rent. Mr. Marr deserve the toilet in prison. Then serve me eviction notes not even on the day of rent but before. His daughter is a cold hearted just like him. Her name is Jessica and she runs her father business located at Community Realty. Take their @$$3s to prison!!!
Why does most everyone jump to the automatic, knee-jerk, and FALSE assumption that cannabis impairs drivers much the same as does alcohol? Why let uninformed opinions be the basis of new laws? It took me very little time to do a search, and find actual scientific studies which indicate just how incorrect such an assumption is. Examples follow.
Studies Show Marijuana Consumption Not Associated With Dangerous Driving, May Lead to Safer Drivers
Anyone who consumes cannabis on a regular basis knows that it doesnt make you a dangerous driver. Many people find that it makes them a safer, more focused driver; one thats more aware of their surroundings and the dangers associated with controlling tons of gasoline-filled metal. Not only has this been an anecdotal truth for as long as cars and cannabis have been paired, science has also been clear that consuming marijuana doesnt make you a dangerous driver, and may make some people safer drivers. More research is needed, but its hard to deny that of the research we have, marijuana hasnt been found to increase a persons risk of an accident. To back this claim up, heres a list of studies and research conducted on this very topic, some of which were funded by national governments in hopes of different results.
Marijuana and Driving: A Review of the Scientific Evidence
"Marijuana has a measurable yet relatively mild effect on psychomotor skills, yet it does not appear to play a significant role in vehicle crashes, particularly when compared to alcohol. Below is a summary of some of the existing data."
The incidence and role of drugs in fatally injured drivers
"There was no indication that cannabis by itself was a cause of fatal crashes."
REFERENCE: Washington, DC: US Department of Transportation, National Highway Traffic Safety Administration,
Report No. DOT HS 808 065, K. Terhune. 1992.
Marijuanas effects on actual driving performance
Evidence from the present and previous studies strongly suggests that alcohol encourages risky driving whereas THC encourages greater caution. .. Drivers under the influence of marijuana retain insight in their performance and will compensate when they can, for example, by slowing down or increasing effort. As a consequence, THCs adverse effects on driving performance appear relatively small.
REFERENCE: University of Adelaide study, 1995
Role of cannabis in motor vehicle crashes
"There is no evidence that consumption of cannabis alone increases the risk of culpability for traffic crash fatalities or injuries for which hospitalization occurs, and may reduce those risks.. The more cautious behavior of subjects who have received marijuana decreases the impact of the drug on performance, whereas the opposite holds true for alcohol.
REFERENCE: Marijuana: On-Road and Driving-Simulator Studies; Epidemiologic Reviews 21: 222-232, A. Smiley. 1999.
"Both simulation and road trials generally find that driving behaviour shortly after consumption of larger doses of cannabis results in (i) a more cautious driving style; (ii) increased variability in lane position (and headway); and (iii) longer decision times. Whereas these results indicate a 'change' from normal conditions, they do not necessarily reflect 'impairment' in terms of performance effectiveness since few studies report increased accident risk."
REFERENCE: UK Department of Environment, Transport and the Regions (Road Safety Division). 2000.
Cannabis And Cannabinoids - Pharmacology, Toxicology And Therapy
"At the present time, the evidence to suggest an involvement of cannabis in road crashes is scientifically unproven".
REFERENCE: G. Chesher and M. Longo. 2002.
Cannabis: Our position for a Canadian Public Policy
Cannabis alone, particularly in low doses, has little effect on the skills involved in automobile driving. Cannabis leads to a more cautious style of driving. However it has a negative impact on decision time and trajectory. This in itself does not mean that drivers under the influence of cannabis represent a traffic safety risk
REFERENCE: Canadian Senate Special Committee on Illegal Drugs. 2002.
"The evidence to suggest an involvement of cannabis in road crashes is scientifically unproven."
REFERENCE: Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential, 2002
Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential, edited by Franjo Grotenhermen, MD and Ethan Russo, MD (Haworth Press 2002).
The Prevalence of Drug Use in Drivers, and Characteristics of the Drug-Positive Group
"There was a clear relationship between alcohol and culpability. In contrast, there was no significant increase in culpability for cannabinoids alone."
REFERENCE: Accident Analysis and Prevention 32(5): 613-622. Longo, MC; Hunter, CE; Lokan, RJ; White, JM; and White, MA. (2000a).
In a 2008 case study published by the International Association for Cannabis as Medicine that explored the potential for THC to have positive effects on attention-deficit disorder, the report's authors concluded that cannabis use could mitigate problems with inattention and lead to "enhanced driving related performance."
The Effect Of Cannabis Compared With Alcohol On Driving
Although cognitive studies suggest that cannabis use may lead to unsafe driving, experimental studies have suggested that it can have the opposite effect. U.S. National Library of Medicine, 2009
Why Medical Marijuana Laws Reduce Traffic Deaths
No differences were found during the baseline driving segment (and the) collision avoidance scenarios,
REFERENCE: Research published in the Journal of Psychoactive Drugs, 2010
Top 10 Reasons Marijuana Users Are Safer Drivers
20 years of study has concluded that marijuana smokers may actually have fewer accidents than other drivers.
Risk of severe driver injury by driving with psychoactive substances
"The study found that those with a blood alcohol level of 0.12% were over 30 times more likely to get into a serious accident than someone whos consumed any amount of cannabis. .. The least risky drug seemed to be cannabis and benzodiazepines and Z-drugs."
REFERENCE: Accident Analysis & Prevention; Volume 59, October 2013, Pages 346356
Cannabis: Summary Report
Cannabis alone, particularly in low doses, has little effect on the skills involved in automobile driving.
REFERENCE: Canadian Senate Special Committee on Illegal Drugs
Acute cannabis consumption and motor vehicle collision risk
"There is no evidence that consumption of cannabis alone increases the risk of culpability for traffic crash fatalities or injuries for which hospitalization occurs, and may reduce those risks."
REFERENCE: British Medical Journal, 1999; M. Bates and T. Blakely
Marijuana-DUI Case Tossed by Arizona Supreme Court in Metabolite Ruling
"Because the legislature intended to prevent impaired driving, we hold that the 'metabolite' reference in [the law] is limited to any of a proscribed substance's metabolites that are capable of causing impairment . . . Drivers cannot be convicted of the . . . offense based merely on the presence of a non-impairing metabolite that may reflect the prior usage of marijuana."
Landmark Study Finds Marijuana Is Not Linked to Car Crashes
Stoned drivers are a lot safer than drunk ones, new federal data show
Study of Fatal Car Accidents Shows Medical Marijuana May Help Curb Opioid Use
Since Passing Medical Marijuana Laws, States Have Seen Lower Numbers of Fatal Car Crashes Involving Opioids
US Traffic Fatalities, 19852014, and Their Relationship to Medical Marijuana Laws
Results. On average, MML states had lower traffic fatality rates than non-MML states. Medical marijuana laws were associated with immediate reductions in traffic fatalities in those aged 15 to 24 and 25 to 44 years, and with additional yearly gradual reductions in those aged 25 to 44 years.
"Stick all *that* in your pipe and smoke it!"
Update: In Preventing Drugged Driving Must Become a National Priority Equivalent to Preventing Drunk Driving, 2015 National Drug Control Strategy ended up admitting that The study found that marijuana users are more likely to be involved in accidents, but that the increased risk may be due in part because marijuana users are more likely to be in high-risk groups for becoming involved in crashes (e.g., young males).
Update 2: "Study: Driving Stoned Wont Make You Much More Likely to Crash"
A new study from the National Highway Traffic Safety Administration says smoking pot does not have a significant effect on a persons ability to drive.
Researchers in Norway say past studies about THC-positive drivers involved in motor vehicle accidents have failed to adequately control for other variables. In other words, authors have been quick to jump on cannabis as the cause - even when it may not have been. The researchers, who are set to publish their findings in the journal Addiction, reviewed more than 20 driving culpability studies and two meta-analyses published between 1982 and 2015. They adjusted the numbers and found acute cannabis intoxication increased crash risk only moderately - by about 20 to 40 percent, or an odds ratio of between 1.2 and 1.4.
By comparison, the U.S. National Highway Traffic Safety Administration reported that driving with legal amounts of alcohol in ones system increases crash risk almost fourfold (an odds ratio of 3.93). Fun fact: Even the National Highway Traffic Safety Administration, a federal agency, acknowledges its difficult to establish a relationship between a person's THC blood or plasma concentration and performance impairing effects.
@Michael Milburn - You say:
>>>"DRUID allows marijuana users (or others who drink alcohol, use prescription drugs, etc.) to self-assess their own level of impairment and (hopefully) decide against driving if they are impaired. Prior to DRUID, there was no way for an individual to accurately assess their own level of impairment. "
Not true. - Marijuana consumers already do a good job of "assessing their level of impairment." - That's part of the reason this is a non-problem. - Marijuana doesn't affect judgement as alcohol does. - Consumers know how impaired they are and usually OVER COMPENSATE for it if it exists - choosing NOT to drive or driving extra cautiously if they have to drive.
Bottom line - marijuana is not a significant cause of auto accidents.
The Prohibitionists are going to push a "per se" level of 5 ng/mL of THC in the blood--legislation like this must be opposed, since the NHTSA acknowledges that blood THC does not predict impairment. We need impairment testing to stop per se laws.
That is why I have developed a new public health app that measures impairment--it is called DRUID (an acronym for DRiving Under the Influence of Drugs) available now in the Apple App Store (Android version coming soon). DRUID measures reaction time, decision making, hand-eye coordination, time estimation and balance, and then statistically integrates hundreds of data points into an overall impairment score. DRUID takes just 5 minutes (and the 2-minute version will be part of the DRUID app in a week or two).
Our website is www.druidapp.com
DRUID allows marijuana users (or others who drink alcohol, use prescription drugs, etc.) to self-assess their own level of impairment and (hopefully) decide against driving if they are impaired. Prior to DRUID, there was no way for an individual to accurately assess their own level of impairment. DRUID also demonstrates that it is feasible to measure impairment reliably by the roadside, not just exposure to a drug.
DRUID was recently featured on NPRs All Things Considered: http://www.npr.org/2017/01/25/511595978/can-sobriety-tests-weed-out-drivers-whove-smoked-too-much-weed
Also on television: http://sacramento.cbslocal.com/2017/02/28/science-lags-behind-marijuana-impairment-testing/
After obtaining my Ph.D. at Harvard, I have been a professor of psychology at UMass/Boston for the past 40 years, specializing in research methods, measurement and statistics.
Michael Milburn, Professor
Department of Psychology
One of the most respected researchers in traffic safety is the National Highway Traffic Safety Administration. - In 2015, they produced the Drug and Alcohol Crash Risk report which found that while drunken driving dramatically increased the risk of getting into an accident, there was no evidence that using marijuana heightened that risk.
In fact, after adjusting for age, gender, race and alcohol use, the report found that drivers who had recently consumed marijuana were no more likely to crash than drivers who were not intoxicated at all.
This has been confirmed by the preponderance of the research, which shows marijuana consumption is NOT a significant cause of auto accidents.
What studies have been done using car simulators? Reaction times are surely quantifiable under these conditions so given enough subjects in straight & stoned states we can build up a reasonable objective database.
It's a serious subject that requires serious study.


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small and cosy. great coffee, nice atmposphere during the day. probably a nice place to go for a night drink (havent been , so not sure about the music) . one of the best little corners in the center of athens with a very nice yard.
Address: | Delfon, Athens, Greece
Location: Europe > Greece > Attica > Athens
Phone Number: +30 21 0363 4583


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Get an overview of this hotelAdults-only Brighton guesthouse in Kemptown, walk to Brighton Sea Life Centre
Collect 200 Nectar points!
Simply enter your Nectar card number when you check out. Your points will be credited 35 days after you return from your trip.*Offers may apply
Popular property highlights
Located in Kemptown, this guesthouse is within a 10-minute walk of Brighton Wheel and Brighton Sea Life Centre. Brighton Royal Pavilion and Brighton Pier are also within 15 minutes.
This smoke-free guesthouse features a bar/lounge, coffee/tea in a common area, and a front-desk safe. Free continental breakfast and free WiFi in public areas are also provided.
Property Features
Room Amenities
All 14 rooms offer free WiFi, TVs, and free bottled water.Information missing or incorrect? Tell us!Opens in a new window
Fab Guest
Guest House Amenities
Guest House Amenities
A bar/lounge is on site where guests can unwind with a drink. Guests can enjoy a complimentary breakfast each morning. Public areas are equipped with complimentary wireless Internet access.
This Brighton guesthouse also offers coffee/tea in a common area and a safe deposit box at the front desk. A total renovation of this property was completed in August 2013.
Fab Guest is a smoke-free property.
- Total number of rooms - 14
- Number of floors - 5
- Bar/lounge
- Coffee/tea in common areas
- Free breakfast
- Free WiFi
- Safe-deposit box at front desk
- Year Built 1830
- Smoke-free property
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Free bottled water
- Daily housekeeping
- Private bathroom
- Hair dryer
- Bathtub or shower
- Television
- Iron/ironing board (on request)
- Free WiFi
Where to Eat
Guests are offered a complimentary continental breakfast each morning.
Guest House Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-in time ends at 7 PM
Special check-in instructions:
Check-out time is 11 AM
Payment types
Children and extra beds
- Children 18 and younger are not allowed at this adults-only property. All guests older than 18 are welcome.
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
Minimum guest age is 18
Caters to adults only
No rollaway/extra beds available
No cribs (infant beds) available
Optional extras
- Early check-in fee: GBP 20.00
- Late check-out fee: GBP 20.00
- Onsite credit card charges are subject to a surcharge
Guest house Name
- Fab Guest
- Fab Guest Brighton
- Fab Guest House
- Fab Guest House Brighton
We should mention
Guests under 18 years old are not permitted at this adults-only property. Only registered guests are allowed in the guestrooms.


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Mura Masa Tickets
Mura Masa Tickets Tickets Rated 0.00/5 based on 0 customer reviews 100 0
Alex Crossan (aka Mura Masa), an 18-year-old UK-based beat-slayer heart-breaker, showcases his minimalist, yet effective approach to UK trap music by combining the energy of electronic production and club culture with the rustic and organic sounds and timbres of traditional sample beatmaking. He manages to create soundscapes that are fresh and unique. His moniker is inspired by the Japanese legend of the sword smith, Mura Masa. You can listen to his tracks on his official soundcloud page, https://soundcloud.com/muramasamusic Read more on Last.fm. User-contributed text is available under the Creative Commons By-SA License; additional terms may apply.
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Ear Wax removal
I'm afraid of cleaning my ears! Its hurts sometimes! I don't have a ear filled with wax but i want to get each and every bit of it removed.
Answers (2)
Like the answers? Chat privately for 24 hours with the doctor of your choice
Hello. I think you should know that a pain from ear canal can occur due to numerous causes like a foreign body( eg- button, seeds etc) stuck in the canal or a live insect crawling in the ear canal. Fungal infection of the ear canal is usually associated with itching. Or it might be infection of hair follicles inside the ear canal. People who swim in unclean water without proper protection, can get inflammation of the ear canal covering due to deposition of that sediments in the canal.in people who have less body immunity to fight infection, tend to have severe form ear canal infection associated with severe pain. There are instances where certain skin illness can also invovle ear canal causing ita inflammation like psoriasis, eczema etc. So kindly consult a ENT specialist for further management.
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Use soliwax ear drops for 1 week and go to a good ENT SURGEON for removal under microscope with suction
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Down on the Island, Up on the Main: A Recollected History of South Bristol, Maine
€ 29,99
Besorgung - Lieferbarkeit unbestimmt
Mai 2003
BeschreibungWhen Ellen Vincent set out to document a working town's history, she hoped to find a place where the families and traditions were part of a generations-old continuum. South Bristol, Maine, a coastal village that spans shore and islands, is just such a place. Sometimes idyllic, at other times laden with hardship, this was a community where self-sufficiency was a virtue and neighbors were as family. The oral history project that Vincent began grew as the community came together to create a collective memory of place, spoken in the words of its people. Their strength of character and unflagging humor has carried them through many decades, and it resonates in the cadence of their tales. These are stories and images that will echo up and down the coast of Maine.
Untertitel: Sprache: Englisch.
Verlag: TILBURY HOUSE PUBL
Erscheinungsdatum: Mai 2003
Seitenanzahl: 320 Seiten
Format: kartoniert


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text: "Whatever you are, be a good one"... and "Oh, silly me. I brought the diet shampoo." umm... hi. I'm 16. I lime to read loads and loads. And I really did just say lime instead of like, didn't I? That's a good start. My favouriye authors include Garth Nix, William Nicholson, James Herriot, JK Rowling, Jean Ure, Edward Lear... etc etc. I'm studying Psychology, Health and Social Care, French and (of course) English Literature at College.