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Pays de Hanau rentals, vacation homes direct from the owners
A good vacation deal to share with family or friends? Destination Pays de Hanau for vacation homes with IHA, the private rental expert. Enjoy the cheapest lodging, promotions and last minute in Pays de Hanau. Book your house, villa, apartment and studio rentals in Pays de Hanau direct by owners without fees nor commissions. Enjoy vacation time and experience an unforgettable stay in Pays de Hanau with vacation home, either short term or seasonal rental. All ads are verified, travel with confidence, your vacations in Pays de Hanau are here!
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Bed and Breakfast for rent in a main farm house
$163* Weekend
Breakfast included
direct by owners
from $82/Night*
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Advert 16565
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Au Fil du Temps Main Farm House 6,500 Sq.ft. in a charming property. country side, courtyard view
2 guest roomsBed and Breakfast Rental in Imbsheim - Bouxwiller in a main farm house #16565 >ParkingHigh chairComfort station
Interior facilities
- Banqueting hall
- Dining room
- Cosy nook
- Tv den
- Bar area
- Reading room
- Countryside vacation
- Ideal for all age groups and conference
- Setting : Quiet, Picturesque
- Forest at 1.25mi.
- Clé vacances : 3 keys
- Festival, Horse riding, Culture
View the advert


text: 177 photos $3,710,000 215 acres 2070 Boonesboro Rd, Winchester, KY 40391 - Clark County 215 acres Winchester, KY 215 /- acres of fantastic raw land available that adjoins with Southwind Golf Course just outside Winchester's Bypass near the Stoneybrook area. Property has been approved and zoned for residential development. Several acres are projected to be positively impacted by the proposed Bypass Extension.

subset: commoncrawl


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Manufacturer: Animal Instincts
Animal Instincts Skin Flings Badger is a terrific soft toy that creates maximum fun and minimal mess.
A squeaker can be found tightly stitched within this plush toy which adds to the limitless fun that this toy creates.
Not only is this toy a boredom breaker that helps stimulate your dog's natural hunting instincts, it also acts as a comforter, due to the super soft material which is luxurious to the touch.
The Skin Fling Badger Dog Toy features a stuffing free interior, giving this toy an advantage over many other toys by not only being less messy, but mimicking that of a hunted animal.


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The Digit is a fascinating brainteaser with very simple rules, endless gameplay and minimalistic design. If you are stuck in a waiting room, listening to a boring lecture or just want to have some fun – start playing and you will soon lose track of time!
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text:
This will be followed by a three-month continuous overtime ban - the first - in an ongoing row over pay.
Mark Serwotka, general secretary of the 300,000-strong Public and Commercial Services Union, said anger among workers subject to a government two per cent pay rise limit had increased after the bail-out of the banks.
He said there was particular fury over Gordon Brown's remark that the Government would "do what it can" to rescue the banks but did not have similar words for the concerns of working families. "This will be the start of a long campaign," he added
The national executive committee of the PCS was meeting this afternoon to approve the strike. It wants to link the action with the National Union of Teachers and the giant Unite union, both of which are holding strike ballots.
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- Banking
- Gordon Brown
- Labour Party
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Need a Cat Allergy Test in Oakland, CA? Simply order online 24/7 and get a fast, affordable Cat Allergy Test at a lab near you (Find More Locations):
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text:
Now, in the taxi, she was approaching the
airport. Sienna felt sick with excitement. She couldn't wait to see Braeden
Sienna spent the flight alternating between
herself and Keir's I-pods. She'd brought them both in her handbag.
Though the flight was tediously long, and she
had to suppress the urge to strangle the couple a few seats away who didn't
seem to be making any effort to shut their three whining and screaming children
up, Sienna managed to get through it.
Braeden was waiting for her when she arrived in
Greece. Sienna was amazed at the heat and fabulous sunshine.
Braeden had acquired a bit of a tan, and had
discovered the trend of large dark sunglasses.
"Go on, tell me everything!"
Sienna grinned, pulling her own sunglasses out
of her handbag and putting them on. They were nice ones, with rhinestone detail
at the corner of the frames.
"Well, the filming of the movie is going
brilliantly! It's sort of cool, because the villain, played by me, wins at the
end. It's sort of a new take on the traditional good verses bad."
Braeden chatted on and on for ages. He was in
his element.
"How'd that interview go?"
He eventually asked.
"It went okay, but some bits were hard. It was
televised, not written, so they couldn't change anything I said. They wanted to
know loads about me and Keir's relationship, quite invasive of our privacy
really. I mean, it was like they wanted to discuss our private life and not
what they'd promised the viewers, the true story of Keir's death!"
Sienna told Braeden.
They talked about the interview for a while.
"They wanted to know about the sort of
religious towns we came from, and seemed genuinely shocked when I told them
some things. I nicely glossed over the fact that Keir shot your dad. I didn't
want a murder crawling out of the woodwork!"
Sienna explained in a lower tone of voice.
"Would you ever get back in touch with your
Braeden asked.
"I'm not sure. I sent them my first book. You
saw in the dedications, one was 'to my parents, your abuse and discouragement
made me all the stronger and more
determined.' I bet they burnt it, like my father burnt the first few chapters
of the manuscript when he and my mother found it in my bedroom."
Sienna told him, sill remembering that most
tragic day of her childhood, the smell of sulphur from the match that had
spread the fatal flame to her writing, the anger in her heart.
"They really burnt it?"
Braeden exclaimed.
"Yeah, totally dismissed it as blasphemy!"
Sienna replied.
"Maybe they'll have got sick of the religion
laws and left?"
Braeden suggested.
"I doubt it. But maybe someday I'll write, or
phone. If their number or address hasn't changed."
Sienna said, thoughtful.


text:
Julies HUGS-(Helping Us Get Safe)
Our Adoptable Pet List
Our Featured Pet...
Biggs and Snoopy, Pit/mixes, They are father and son! They were supposed to go to a different rescue, but on transport from the kill shelter in NC where they came from, the rescue NEVER showed up to pick them up. They couldn't be sent back to the shelter to die, so they are in a friend's home, but they really need a home of their own! You don't have to adopt both, but If you think you'd like to adopt, just send me an email to firstname.lastname@example.com or give me a call for questions at 570-773-3077. If you'd like an application I'll be happy to send you one. Their adoption fee is $200 each. Very nice boys they are. They lived with children previously and were fine with them. They get along well with each other. THANKS for looking!
Click to see our pets!
I'm not a 501c non-profit organization, right now it's just myself and one other Foster Mom rescueing the dogs that we can and trying to find them new, loving homes. I would love to have people willing to foster a dog or cat so that more animals could get a second chance at finding a loving, forever home. My breed of choice is English Springer Spaniels, but I don't feel that they are the only dogs worth saving. Even mixes are wonderful companions! If someone would like to help foster, you can pick the animal that you want to assist, I won't tell you what you are to foster. Also since I'm not 501c, I can only rescue 1 or 2 dogs at a time as I have 3 dogs of my own and my fosters are kept inside the home as if they were my own dogs. I've had to turn dogs away because I'm full with the fosters that are here and our own dogs. I could truly use foster families! It's really not as hard as you think, and you'd be helping to save lives! More and more people are giving up their pets due to these economic hard times, illnesses, moving to find a job, etc. Please be good to your pet, they depend on you! Also please make sure you spay or neuter your animal to prevent unwanted pregnancies, cancers that develope because the animal is intact, and it helps curb aggression and urinating inside on your furniture/walls! Do you or anyone you know have to give up your pet? If so, PLEASE don't wait until the last week/day to start looking for a home for them and even if you find someone who says Yes, I'll take the dog, get one or two MORE people who will say yes to adopting/taking the dog! Why, when the day comes to actually take the dog, they may have had time to think about it, and said yes too hastily! Then they back out and won't take the dog, what do you do? Pull your hair out! If you have a back-up or two, you may prevent yourself from going bald! Line up a rescue just in case the person changes their mind! Maybe they fell and hurt themselve and is having trouble just taking care of themselves, maybe they got sick, maybe they just became a Grandparent and the dog doesn't like kids, maybe your kids were forced to move back in with you and the dog doesn't like kids. GET A BACK-UP or two! If you have a purebreed dog, you are LUCKIER than the mix breed dog, as purebreds ALL have a rescue willing to help them out! You can find a rescue near you by going to http://www.akc.org under Breed, you will find Rescue, even if it says National or it's not close, WRITE to ANYONE listed, they may know someone in your area, or can get the word out about your dog! They even have purebreed rescue for cats as well! Petfinder has MANY rescues listed, some all breed, usually depending on Volunteers, they are full, but if you don't ask, you don't know! If you are going to post a dog "FREE to GOOD HOME", PLEASE at least ask for a Vet reference, call the Vet and ask if the pet was well cared for, did they bring it in annually for shots? Was it heartworm tested and on prevention? There wasn't any signs of abuse/injuries? 2) Ask for 2 personal references, not family members, as family unless you screwed them over, will give a good eval, ask for non-family references, friends, co-workers, a boss, neighbor, call them to see if they are honest, trustworthy folks, is there any abuse in the family, any drugs, trouble with the law? Call your local shelters and ask if they have been declined to adopt, if so why? Does anyone recognize the name as not being a good adopter? Call the local police dept and see if they know the name, if not at least that's good, better than them knowing the name for bad reasons! ASK to come to their house to see how the animal does at their home, if they say no, don't allow the pet to go there! Ask if you can come back to visit? If no, don't leave the animal there! You've loved that animal for however long you had it, would you like to worry about how's it doing, or know you DID EVERYTHING possible to try and find the bEST home possible for it! WHY YOU SHOULD NEVER GIVE YOUR PET AWAY FOR FREE! There are 3 labs alone in Schuylkill County who will accept animals to be used in their tests, anyone can turn them in and receive money for them, unless the animal has been microchipped, they can not use any animal that is microchipped, usually these people can't don't know if a pet is micro-chipped to prove that they are the true owners of the animal. They can lie about where they got them if they get them free from ads, or steal them from your home/backyard.
Who We Are
I don't have a shelter or shelter hours as these dogs live in my home, so appointments are needed to come and meet the potential new family members. . I get fosters from shelters, owner surrenders, possibly a friend will call me and inform me of a dog in need of a foster home either due to neglect or moving, etc. I can only help 1 or 2 dogs at a time due to owning 3 dogs myself. I will ALWAYS take back any dog that I have adopted out, for any reason! The dog is NOT to be given to someone else, without verifying from me first, and I'd need to give written permission for it to be legitimate. The dog is NOT to be taken to a local shelter and dropped off, nor used for medical experiments! The dogs are to live inside, not outside tied up or living in a dog house.They are to be family members and treated/loved as such. If I help a dog, the dog MUST be good with other dogs and no bite history. But sometimes depending on the circumstances, I will foster the dog and evaluate it myself if it does nip someonet It's not always a done deal. I don't claim to be a behavior trainer, nor a Vet tech with medical training, so each and every one of my foster dogs to be seen at the Ringtown Valley Veterinary Hospital, Dr. Ronald Bernhart, Vet. 570-889-5023 where they are checked over for any medical problems, given any shots they may need, and heartyworm and lyme tested and put on both Frontline for fleas, and Interceptor once they are ruled as heartworm neg.
Adopting a friend
These are my requirements for adopting a dog that I have needing a new home. I require an Adoption Application to be completed, I'll be happy to email you the forms, I require 2 personal, non-family members references, and a Vet reference if you've owned other animals previously, those will be listed on the Adoption Application that I can call to verify your references. I require an Adoption Contract completed if you are the person who will be lucky enough to adopt a dog. You and your entire family have to agree on this particular dog, but the dog must also pick you as his/her new family! A home check will have to be completed prior to adoption, if you live close enough to me, I will come and do the home check myself, bringing along the dog that you're interested in adopting so that I can see if it will be a match for both of you. If you don't live close enough, I'll arrange for someone else to do the Home Check. As, I'm on Social Security Disability, my adoption fees are to recoup the Vet Bills, so each dog could be a different Adoption Fee. If the dog is already spayed/neutered the fee will be less, but if a dog needs to be spayed/neutered, get all of his/her shots, and heartworm tested, this is all costing approx $225.00 or more As The Vet prices increase, so does my adoption fee to help cover the expenses. Also depending on the breed of dog, more expenses to ensure the health of the dog may be required which increases the adoption fee. . But, in return you are getting a dog without parvo, heartworms, and be in good health that without unforseen complications/accidents, you shouldn't need any medical treatment, other than Interceptor and Frontline, for a year.
Come Visit Us!
Our Happy Tails Tales- Pictures of our ALREADY adopted dogs!
Click to see our pets!
Appointments are required as there is no shelter, just my home to view the dogs at. This means though I can usually accomondate hours that are best for you and myself.
Julies HUGS-(Helping Us Get Safe)
30 Vulcan Rd
Barnesville, PA 18214
Phone: 570-773-3077
Click here for a list of pets at this shelter
] [
] [
] [
Happy Tails


text:
Winchester Bulk Pack Rimfire Ammo
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Winchester® Bulk Pack Rimfire Ammo is the perfect commodity for high volume shooters who enjoy plinking, varmint and small game hunting, and target practice. Driving a copper-plated, lead bullet at high velocity, Winchester .22 ammunition cycles in semi-autos, as well as any type of firearm action, leaving minimum lead residue in the barrel, feed ramp, or forcing cone. The clean-burning powder and priming also contribute to maintaining firearm actions clean for reliable function. Winchester Bulk Pack is a great value for accurate and reliable rimfire ammo.
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text:
extemporizeverb [ I ]formal UK usually extemporise uk /ɪkˈstem.pər.aɪz/ us /ɪkˈstem.pɚ.aɪz/
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the action of smoking a cigarette, pipe, etc., or the activity of doing this regularly


text:
|Publication number
|Publication type
|Application number
|Publication date
|Dec 29, 2009
|Filing date
|Apr 14, 2005
|Priority date
|Apr 14, 2004
|Fee status
|Also published as
|Publication number
|Jian-Zhong Qian, Guo-Qing Wei, Li Fan
|Original Assignee
|Edda Technology, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (5), Referenced by (6), Classifications (23), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention claims priority of provisional patent application No. 60/561,893 filed Apr. 14, 2004, the contents of which are incorporated herein in their entirety.
1. Field of the Invention
The present invention relates generally to a system and method for computer assisted medical diagnosis. Specifically, the present invention relates to a method and system for lesion detection procedures in diagnostic imaging.
2. Description of Related Art
A number of areas in diagnostic imaging have advanced rapidly, which makes a large amount of data readily available to medical personnel. However, advantages from these technological advancements also lead to new problems. For example, CT based cancer screening has progressed significantly. Different CT procedures enable large amount of data to be generated, which usually require tremendous effort from radiologists to examine such data to reach medical conclusions. To improve efficiency in processing such information, certain protocols governing medical data interpretation have been put in place. Although such protocols may assist radiologists to perform data interpretation in a more structured manner, performance of radiologists often varies significantly due to the amount of data. Such inconsistency complicates diagnostic decision making.
Second, various lesion/cancer databases have been established to encourage information exchange and sharing. One important application of such databases is to develop, test, and validate computer algorithms designed to detect and characterize different types of lesion/cancer. Effective use of such cancer databases often requires the availability of ground truth for lesion/cancer present in medical images and such ground truth is preferably validated by other means such as biopsies. However, due to the high cost of and extreme difficulty in acquiring ground truth, approximate ground truth is often used, which may be generated using lesion/cancer marks manually created by physicians. Unfortunately, establishing consistent lesion/cancer marks has proven to be very difficult. This is due to the fact that lesion/cancer markings of a patient study created by a radiologist at different times or by different radiologists often exhibit considerable variations. The former is called intra-observer inconsistency and the latter is called inter-observer inconsistency.
Generating consistent lesion/cancer markings has become a critical problem in diagnostic imaging and analysis. Recent research shows that markings created by radiologists at an expert level often have the same problem. Although this problem has attracted much attention, no effective solution has been proposed that adequately addresses the problem.
The invention claimed and/or described herein is further described in terms of exemplary embodiments. These exemplary embodiments are described in detail with reference to the drawings. These embodiments are non-limiting exemplary embodiments, in which like reference numerals represent similar structures throughout the several views of the drawings, and wherein:
The present invention relates to a method and system for quality assurance in lesion marking and characterization. A method and system are disclosed herein for lesion marking with reduced intra and inter-observer inconsistencies. A lesion marking protocol is electronically enforced during the process of creating a lesion marking. Multiple markings created with respect to a lesion may be utilized to allow creation of a consensus lesion marking. Measures of intra-observer and inter-observer inconsistencies are estimated with respect to markings created for the same lesion. Such measures are used for quality assessment and assurance purposes. Information associated with lesion markings and creation thereof can be analyzed to derive statistics and knowledge that can be fed back to direct future lesion marking processes.
Lesion marking refers to a process in which a marking is created with respect to a lesion contained in a patient study such as an image taken from an organ of a patient. A marking may correspond to any representation of an indication. For example, it may correspond to an arrow pointing at a location in an image where a lesion may be present. It may also correspond to a drawing that represents the boundary of a lesion. It may also correspond to a bounding box in which a lesion is present.
During a lesion marking process, the user 101 may interact with the lesion marking mechanism 125 through the user interface 105 to create a lesion marking based on the displayed patient study. For example, the user 101 may make markings or draw on a display screen where the user interface 105 is rendered. Upon receiving the marking coordinates drawn by the user 101 from the user interface 105, the lesion marking mechanism 125 may perform real time detection and quantification of the marked lesion based on the marking received. Measures may be made with respect to the lesion marked and such measures may then be displayed on the user interface 105 so that the user 101 can observe the outcome of the marking created. The user 101 may activate intelligent and interactive lesion analysis tools contained in the lesion marking mechanism 125 to assist marking, for example, suspicious regions in an image as lesion areas. Tools, such as real-time 3D visualization, real-time lesion quantification, and interactive control may be utilized to aid the lesion marking process. In addition, qualitative and/or quantitative properties computed with respect to a marked lesion may be generated. Such lesion properties may be used by the electronic protocol enforcement mechanism 132 to ensure that the created marking complies with a protocol 130 for quality control. In some embodiments, a warning may be issued, if the lesion properties are not consistent with those defined in the protocol 130.
In some embodiments, when a patient study is loaded for lesion marking, a corresponding marking result retriever 120 may automatically search, in a lesion mark database 145, for any previous lesion marking records associated with the same study. Such recorded information related to a previous marking may be used in a current lesion marking process to minimize the inconsistency that may arise under different situations. For example, viewing parameters of a previous lesion marking process may be extracted, by a display parameter retriever 115, and used to reproduce a viewing environment applicable to a previous marking process in which the previous marking is created. In some embodiments, an action sequence taken in the previous lesion marking process may also be recorded and retrieved in a future marking process so that it can be used to replay the entire lesion marking decision process or a portion thereof with respect to any particular lesion.
Features associated with each previous marking may also be utilized for quality assurance purposes. For instance, the location and size of a lesion derived based on a previous lesion marking may be used to compare with similar measures derived from a lesion marking created in a current marking process. A marking property retriever 122 may extract information related to a previously generated lesion marking and forward such information to the electronic consensus panel controller 135 for consistency checking and quality control. Characterization properties of a previously created marking may be compared with that of a lesion of a current marking through the electronic consensus panel controller 135. The e-consensus panel controller 135 may present different sets of features associated with different markings on an electronic consensus panel so that the user 101 can compare the features and examine the discrepancy. In some embodiments, a confirmation of consistency or a warning of inconsistency message may be generated and displayed to the user 101. The user 101 may be given an opportunity to interactively respond to such displayed conclusion.
Through the e-consensus panel, the user 101 may be provided with an opportunity to interactively derive an improved lesion marking in light of the discrepancy between the two markings. Derivation of an improved marking may be based on all available information associated with both the current and the previous marking processes. The user 101 may choose to accept or reject the current marking or specify how the two markings may be combined/fused to generate an integrated marking. When a choice is made, the chosen marking may be treated as a consensus marking. Information related to the accepted marking such as viewing settings, action sequences, and lesion properties, may be automatically archived (if not already done), via a marking archiving mechanism 142, into the lesion mark database 145.
In some embodiments, information stored in the lesion mark database 145 may be analyzed by a marking analysis mechanism 150. Various analyses may be performed to derive statistics and to develop knowledge associated with lesion marking. For example, a benchmark study may be performed based on information stored in the lesion mark database 145 to derive a correlation between different categories of factors (e.g., imaging parameters) and the quality of generated markings. As another example, analysis may be performed based on stored lesion markings to determine typical characterization of different types of lesions (e.g., average size of liver cancer) with respect to, e.g., different race/age groups or stage of the underlying diseases. The analysis may also be carried out with respect to, for example, individual physicians or a group of physicians. From such analyses, collective or individual marking behavior and/or performance may be identified. For example, a specific physician may tend to make a certain kind of mistakes. This behavior pattern may be used in future lesion marking processes, for example, when the specific physician participates or in selection of qualified physicians for marking purposes.
In some embodiments, such derived statistics and knowledge may be stored in a knowledge database 155 and/or can be fed back to the e-consensus panel controller 135 and utilized in a lesion marking process. Details related to various components of the system 100 are discussed below with reference to
The lesion characterization mechanism 220 may be configured to be capable of various operations that can be applied to a given patient study based on a marked lesion position (e.g., a marking). For example, the lesion characterization mechanism 220 may provide the capability of automated or interactive image segmentation. In some embodiments, a given lesion marking position may provide a parameter for a segmentation process. For instance, a marking may be placed at the interior of a lesion and an automated region based segmentation process may use the marking as a seed to continue a region growing process until reaching the boundary of the lesion. In different embodiments, an interactive segmentation process may also be applied, e.g., within a marking that is a bounding box of a lesion, that allows a user to, for example, specify a number of points along the boundary of a lesion and then an automated interpolation process is applied to derive an optimized lesion boundary. In some embodiments, an automated segmentation may also be coupled with an interactive segmentation process. For example, a lesion boundary generated by an automated segmentation routine may be interactively adjusted via an interactive segmentation algorithm by allowing a user to drag and move a portion of the automatically segmented boundary or by adjusting some governing parameters of the segmentation procedure.
In some embodiments, the lesion characterization mechanism 220 may also be capable of provide quantification of a lesion. Quantitative measurements may include, but are not limited to, the size or volume of the lesion, calcification pattern, attachment pattern with respect to other anatomies, a measure indicating how likely it is that a lesion exists, and a measure indicating how likely it is that the detected lesion is malignant.
The interactive control mechanism 240 may facilitate any interactions between the user 101 and the lesion marking mechanism 125. For example, the user 101 may interactively change or refine the lesion boundary. In this case, the interactive control mechanism 240 may facilitate such interactions by activating the lesion characterization mechanism 220 and the real time visualization mechanism 230 to accordingly effectuate the user's intention. For instance, if the user 101 changes a lesion contour segmented by the lesion characterization mechanism 220, such changes, when received by the interactive control mechanism 240, are forwarded to the lesion characterization mechanism 220 so that features with respect to the revised lesion may be derived. Such recomputed features, together with the revised lesion boundary, may also be forwarded to the real time visualization mechanism 230 so that the lesion boundary as well as newly derived features may be re-displayed to the user 101.
In some embodiments, the interactive control mechanism 240 may be configured to provide a user the ability to enter annotations. For example, a user may be provided with the means to select a lesion associated with a marking and to enter relevant comments and/or notes associated with the marking and/or lesion. In some embodiments, the interactive control mechanism 240 may also be configured to provide a user the ability to query. For example, a user may be allowed to query against a database. Such a query may be formulated based on different criteria such as a type of lesion, a size measure, a shape, an attachment pattern, or some statistics such as an average intensity level within a lesion or an average texture measure with respect to a particular type of lesion. The interactive control mechanism 240 may facilitate communications between a user and a database where a query is sent, receive the query result, and display the result to the user. Such a query may be issued against the knowledge database 155 or any other local or remote databases.
The marking process information recording mechanism 250 records different types of information associated with the lesion marking process. Such information, when a marking is accepted, may be sent to the marking archiving mechanism 142 to be stored together with the marking itself. Information related to activities that occurred during a marking process may provide some insight as to the rationale or reasoning that a user relies on to mark a suspicious region. To maximize the consistency between/among different markings, it may be helpful to provide information reflecting such activities. In addition, such recorded information may assist one in reaching an understanding of particular intra- and inter-observer discrepancies.
In some embodiments, information related to marking decision making may include parameter selections made and/or operations performed during a marking process. Conditions under which an image or a specific portion of an image are visually examined may influence a user's decision in marking and characterizing a lesion. To develop consistent marking with respect to the same lesion, it may be helpful to present an image under the same conditions as when a previous marking for the same lesion was created, for instance, viewing parameters a user selects with respect to each region for which a marking and its underlying lesion characterization is performed. Such viewing parameters may include a window level for image display, a magnification factor applied, a viewing mode (e.g., original image, Maximum Intensity Projection (MIP), or volume rendering), and/or a specific orientation (e.g., axial, sagittal, or coronal).
In some embodiments, information about a sequence of actions/operations taken with respect to a lesion marking process may be recorded. For example, a user may use specific interactive segmentation tools coupled with some particular volume rendering tools to examine a region suspected to contain a lesion. Such actions/operations undertaken by a user may influence how and why the user reaches a conclusion associated with a marking and may be recorded with respect to each of the marking positions.
In some embodiments, such recorded action sequences, when coupled with the recorded corresponding viewing parameters, may enable a replay of the entire user interaction process. Such replay may be effectuated via movie clips or by reproducing a previous process by applying a recorded action sequence to a data set. The former usually has a higher space requirement and no future interaction is possible. The latter often yields savings in terms of space. In some embodiments, the latter makes it possible to allow a user to participate in the process in which a recorded action sequence is being reproduced. For example, a previous interactive segmentation process to delineate a lesion boundary may be reproduced base on the recorded tools used and the threshold parameters set in such tools. A user in a different marking process may be allowed to adjust, during the replay, the threshold parameters for the tools used in the previous interactive segmentation process and observe the impact of such threshold change on the segmentation results.
The protocol 130 may refer to one or more criteria to be complied with when a user creates a lesion marking. One of the important factors attributable to reading inconsistencies may be that radiologists often employ different criteria when they create markings. Although sometimes radiologists may agree to use a protocol, when there is no effective mechanism to enforce the protocol in the process of creating markings, the markings generated are still subject to both inconsistency, including both intra-observer inconsistency and inter-observer inconsistency. The former refers to the situation where lesion markings created by a radiologist at different times are inconsistent. The latter refers to the situation where lesion markings created by different radiologists are inconsistent. In the invention described herein, the protocol 130 is electronically enforced during the process when a radiologist creates a lesion marking to reduce both intra-observer and inter-observer inconsistencies.
The protocol 130 may be established in different ways and may be updated over time. In some embodiments, the protocol 130 may be in the form of an electronic file, containing descriptions of criteria to be satisfied during creating a lesion marking. A template file may be used to formulate the criteria for marking a lesion. Such a template may include one or more parts, including, for example, a general description and/or a category matrix. A general description may define what is to be marked such as the type of abnormality to be marked, a feature description such as a size range of the lesion to be marked, whether it should be calcified, and/or whether other abnormalities other than a lesion form should be marked. A category matrix may describe detailed features for lesions to be marked, including, but not limited to, shape, malignancy likelihood, status regarding solidness of a lesion, calcification distribution, a form of connection to other structures, subtlety, and/or treatment categories.
Criteria so defined in the protocol 130 may be enforced against features extracted from a lesion segmented based on a marking. For example, when the measured size of a lesion falls out of the range specified in the protocol, the underlying marking may be considered inconsistent or invalid. Such enforcement decision may be communicated to the user 101 so that, for example, the user 101 may re-examine the patient study and interactively reach a decision as to the validity of the marking.
The protocol 130 may include some criteria that may not be as precisely quantifiable, which may leave room for ambiguities. In some embodiments, the protocol 130 may be enforced in a different mode of operation through a test reading procedure. During a test reading procedure, pre-selected sample patient studies, which may contain both abnormalities that are easily missed and ones that are often over-marked (i.e. cases that should not be marked but are often mistakenly marked by radiologists), may be used to test a user by requesting the user to create a marking. The test marking result may then be compared with corresponding element(s) of the protocol 130 as to whether the marking created by the user is consistent with the protocol 130. The test reading procedure may be viewed as a process to train a user to avoid markings that are not consistent with the protocol 130. In some embodiments, the protocol 130 may include links to such testing samples and such links may be activated when a marking generated by the user 101 is not consistent with the ground truth of the sample images of that category. Therefore, the test reading procedure may serve as a means to inform and educate a user as to the requirements that the protocol 130 intends to enforce.
A different aspect of reducing intra-observer and inter-observer inconsistency in addition to electronic protocol enforcement relates to consistency checking performed when multiple markings are present for a single lesion.
When multiple markings are made for the same lesion, the e-consensus panel controller 135 may check the consistency of the different markings and interact with the user 101 to attempt to reach a consensus. The current lesion property retriever 410 obtains features characterizing a marking created in the current marking process and the previous lesion property retriever 420 obtains features characterizing a previous marking. Both sets of features are forwarded to the consistency check mechanism 450 where the two sets of features may be compared and analyzed in terms of marking inconsistency. The consistency check result reporting mechanism 460 may receive the comparison result and report the same to the user. When a discrepancy exists, the consensus determiner 470 may interact with the user in order to resolve the discrepancy and to reach a consensus.
In some embodiments, both the current and the previous markings may be displayed side-by-side on a display screen for visual comparison and inspection. Inconsistent measurements may also be presented to the user for examination. Furthermore, the action sequences of the two marks may be retrieved. The user may be given the option to reproduce a previous marking process based on the action sequences. Such reproduction may be carried out fully or partially, focusing on the portion where the inconsistency may have occurred.
In some embodiments, the consensus determiner 470 may conduct different interactive processes for intra-observer and inter-observer inconsistencies. For intra-observer inconsistency, a side-by-side quantitative comparison may be performed. If a previous marking is not marked at the current location, a user may be prompted to check the previous marking using recorded viewing parameters and action sequences. If the user decides that both the previous marking and the current marking are acceptable, the user may be given the option of merging the two markings, e.g., by transferring the previous marking to the current reading. If the user determines that the previous marking should not be accepted in the current reading, then the current marking may be treated as a consensus marking.
An inter-observer inconsistency often corresponds to a situation where a patient study is marked on different systems. In those situations, previous marking results may be imported through means such as FTP, web download, or email via network connections such as the Internet, LAN, WAN, etc. There may be more than one previous marking. In some embodiments, the most recent previous marking may be considered to be an integration or consensus of all previous markings. This is a progressive mode of reaching a consensus among different markings. In some situations, there may not be a consensus reached among multiple markings. In this case, to ensure consistency, each marking may be sent to a third party for a benchmark analysis or to other marking creators for inconsistency checking.
There are scenarios where multiple medical centers read the same set of patient studies. Marking inconsistencies among different medical centers may be analyzed at a statistical level instead of at an individual level. For example, comparison of different markings created by different centers may be carried out based on statistics collected at each medical center. Cross-center inconsistency may then be accordingly defined based on such statistics. For example, if a degree of inconsistency is defined based on a difference between corresponding likelihood attributes of two markings, then each medical center may compute a series of statistics such as the percentage of consistent markings, an average degree of inconsistency, a variance of the degree of inconsistency, the percentage distribution of markers with a certain degree of inconsistency, the same statistical measures as above but for consistencies of characteristics of markings. Such statistical measures from different medical centers may then be used to assess levels of inconsistency/consistency across different medical centers.
Flowcharts of different exemplary processes related to the system 100 and different components thereof as described herein are discussed with reference to
An interactive lesion marking process is conducted, at 540, in a manner that is in compliance with the electronically enforced protocol 130. With respect to each marking so created, a consistency check is performed, at 550, between a marking created and one or more previous markings. When inconsistency exists, a consensus is reached at 560 that gives rise to a marking that can be used in a future lesion marking process as a consensus marking. Such a consensus marking is then archived, at 570, together with information associated with it such as viewing parameters and action sequences, etc. The archived markings stored in a database may be analyzed, at 580, to obtain various statistics/knowledge. Details related to interactive lesion marking, consistency checks, and electronic consensus marking are discussed with respect to
While the invention has been described with reference to the certain illustrated embodiments, the words that have been used herein are words of description, rather than words of limitation. Changes may be made, within the purview of the appended claims, without departing from the scope and spirit of the invention in its aspects. Although the invention has been described herein with reference to particular structures, acts, and materials, the invention is not to be limited to the particulars disclosed, but rather can be embodied in a wide variety of forms, some of which may be quite different from those of the disclosed embodiments, and extends to all equivalent structures, acts, and, materials, such as are within the scope of the appended claims.
|Cited Patent
|Filing date
|Publication date
|Jun 3, 1997
|Aug 3, 1999
|Neo Path, Inc.
|Cytological slide scoring apparatus
|Nov 26, 2002
|Nov 13, 2007
|Ge Medical Systems Global Technology Company, Llc
|Computer aided diagnosis of an image set
|Aug 26, 2002
|Feb 13, 2003
|Callaway W. Scott
|Managing images of microscopic specimens
|Sep 30, 2002
|May 22, 2003
|Wood Susan A.
|Graphical user interface for display of anatomical information
|Feb 21, 2002
|Sep 4, 2003
|The University Of Chicago
|Detection of calcifications within a medical image
|Citing Patent
|Filing date
|Publication date
|Oct 17, 2007
|Jun 14, 2011
|Technische Universit�t M�nchen
|System and method for on-the-fly segmentations for image deformations
|Jan 21, 2005
|Sep 18, 2012
|Edda Technology, Inc.
|Method for intelligent qualitative and quantitative analysis assisting digital or digitized radiography softcopy reading
|Jan 21, 2005
|May 4, 2006
|Edda Technology, Inc.
|Method for intelligent qualitative and quantitative analysis assisting digital or digitized radiography softcopy reading
|Oct 17, 2007
|Aug 14, 2008
|Thomas Schiwietz
|System and method for on-the-fly segmentations for image deformations
|Jul 10, 2012
|Jan 31, 2013
|Olympus Corporation
|Image processing device, image processing method, and image processing program
|Jan 9, 2014
|Jul 10, 2014
|Samsung Electronics Co., Ltd.
|Lesion diagnosis apparatus and method
|U.S. Classification
|382/128, 436/43
|International Classification
|Cooperative Classification
|European Classification
|Apr 14, 2005
Owner name: EDDA TECHNOLOGY, INC., NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:QIAN, JIAN-ZHONG;WEI, GUO-QING;FAN, LI;REEL/FRAME:016478/0648;SIGNING DATES FROM 20050412 TO 20050414
|May 29, 2013
|Fee payment
Year of fee payment: 4


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PhosphoSitePlus® Resource
- Additional protein information
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Crizotinib #4401
Western blot analysis of extracts from KARPAS-299 cells, untreated or treated with crizotinib (1 hr) at the indicated concentrations, using Phospho-ALK (Tyr1604) Antibody #3341 (upper) or ALK (D5F3) XP® Rabbit mAb #3633 (lower).Learn more about how we get our images
Chemical structure of crizotinib.Learn more about how we get our images
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Crizotinib is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 2.5 mg in 5.55 ml DMSO. Working concentrations and length of treatments vary depending on the desired effect, but it is typically used at 0.1-1 µM for 2-6 h. Soluble in DMSO at 25 mg/ml with warming; very poorly soluble in water with maximum solubility ~10-20 µM.Storage: Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Molecular Weight:
450.34 g/molPurity:
>99%Molecular Formula:
Crizotinib, also known as PF-02341066, is a novel, ATP-competitive receptor kinase inhibitor, showing high specificity for c-Met and anaplastic lymphoma kinase (ALK) over 120 other diverse kinases (1,2). Researchers have shown that crizotinib inhibits c-Met phosphorylation and c-Met-dependent proliferation, migration, and invasion of human tumor cells in vitro (IC50 values of 5–20 nM) (1). Crizotinib is effective against the constitutively active oncogenic fusion protein nucleophosmin (NPM)-ALK, inhibiting its phosphorylation (mean IC50 of 24 nM), inhibiting cell growth, and inducing G1-S phase cell cycle arrest and apoptosis in the ALK-positive ALCL (anaplastic large-cell lymphoma) cell lines KARPAS-299 and SU-DHL-1 (2).
1. Zou, H.Y. et al. (2007) Cancer Res 67, 4408-17.
2. Christensen, J.G. et al. (2007) Mol Cancer Ther 6, 3314-22.
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.


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Mesopotamia is one of the most ancient civilizations we know to have existed. What predates the wisdom of Mesopotamia is clearly unknown to us. Some could say Atlantis but this is not yet a scientific fact although much effort has been made by Archeologists from all over the World to prove the existence of this Legendary Civilization.
The art of Knot Magic could be an imitation of what the Moirae (and Norns) do. As we saw in depth in a previous article the Triple Goddesses of Fate are constantly weaving the Destinies of Humans and others! The art of weaving can be seen as the symbolic action of dealing with the endless possibilities giving a certain form to what was previously just a cord, thus deciding which will be the fate who mates with each one of us. By practicing Knot-Magic we try to add or maybe alter what the Fates have already decided for us. Modern Practitioners regard the Moirae/Norns/Fates as the personification of the Karma rules and powers. In this case Fate has not been decided yet and every Magical Action can influence Karma as it is a conscious decision to change Reality.


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|Reviews for BotGiOh!
| chitoryu12 chapter 2 . 6/13/2005
Wow! What a fic! And I love the innuendo with the nuts!
| This account exists no more chapter 1 . 1/6/2004
I love BattleBots. This is a darn good story. Hehe... Bil Dwyer vs. Yugi? I'd love to see that...
| Teen Miles Prower chapter 4 . 9/6/2003
XD That was awesome! I had a feeling Mokuba would win.. I don't know why... Anyway, my favorite part was when Yugi looked like he was going Super Saiyan and Kaiba reminded me of Vegeta for some reason. Then Marik felt a great power and got a b- *a train goes by* and then King Kai was talking to Yugi. DBZ is awesome! And I have a headache again... P Thank you, you have made my great day even greater! Keep up the great writing!
| Matthew John chapter 4 . 9/6/2003
Dammit, I was going to do the Mary Sue sequence...oh well. Poor Yami, though - she'll probably be able to use Exodia or something right out of the box...
| Teen Miles Prower chapter 3 . 9/1/2003
Yeah, how will Joey get out of this one? And the way Mokuba acts in here actually doesn't surprise me anymore... I read the manga and he's EVIL in there... Anyway, this chapter was funny too. Yeah, I know what you mean about losing interest. But at least you're not as bad as me. I only have ONE completed story... Keep up the good writing!
| Matthew John chapter 3 . 8/27/2003
The "heart of the cards" sequence really made my day, man!
| Samisnumber1 chapter 2 . 6/6/2003
Funny I can't wait to see the next chapter , you haven't updated for almost a month this next chapter better be real long and real good or else I will sick my God Beast on you, and so you know you can have 5 monsters on the field, but they must be in the monster zone in face up attack or defense mode, or face down Defense mode. U may have up to 5 magic or trap cards out at a time and thats all you nead to correct.
| Teen Miles Prower chapter 2 . 5/26/2003
XD! Geez, this story is insane! When I was reading it, I got a headache laughing! Keep up the good work! Hee hee...
| Random Otaku Boy chapter 2 . 5/16/2003
Silly Barnaby... He's a psycho-geek! Ya know what? Those battlebots have funkitated names! And Yami dude is all like.. Smooth like yogurt; it's kinda scary... Wah! Those Rare Hunter dudes are freakish! ...And me oh my are they stupid! Good thing Mai got away.. Heehee, Kaiba is silly . And Mokuba is getting scary! Poor child getting corrupted by Eminem... Hee . Serenity's so nice and that Sumao kid is creepy.. I hope Tristan kicks his butt! ..Kinda. Not too bad, because Sumao isn't really that bad, just kinda scary. Malik is funny . Poor Mai, now she's gonna get kidnapped! Dunandun... Can't wait for the next chapper! Big smoches! .
| MagicmanSmokegirl chapter 2 . 5/11/2003
If it helps, here's a list of my favourite battlebots.
Bio Hazard
These four rule the battle box!
| Matthew John chapter 2 . 5/10/2003
Jeff the Rare Hunter? That's...wrong.
The Eminem Effect will be a running gag, which is always great.
| Matthew John chapter 2 . 5/10/2003
Jeff the Rare Hunter? That's...wrong.
The Eminem Effect will be a running gag, which is always great.
| Random Otaku Boy chapter 1 . 5/7/2003
I know I've said it before, but yaay! A new story! . I really like the beginning of this one too! Heehee, Yugi's Grandpa is such a perv . I hope he has... uh, fun with Carmen Electra .; Joey's so dumb... 3,0 yen is 20 bucks? I wonder how much yen one dollar is? Hm.. I'll go look that up later. And Tea is so... friendly! I didn't know Tristan had a crush on Serenity.. it's kinda cute! Heehee, and Kidz Bop . Slim shady slim shady slim shady slim shady slim shady.. Ahh, I could sing that all day! How rude of Barnaby.. How rude of Barnaby's parentals to name him Barnaby! Anywho, I wanna see more chappers soon! Soon soon soon! I want to see Barnaby get beat by Yugi! (Even though I feel very sorry for him for having to be named Barnaby...) Anwyho, big smooches! .
| Super Hurricane chapter 1 . 5/5/2003
Son of Whyachi is good, but only when it's spinning, Don't forget, a deck is made of more than monsters, but also with power-ups and traps. I prefer them in a ring as Element Cards and Snare Hazards. I'll review later, as I wish to duel Joey, as he was born in America. As if you forgot that.
| Matthew John chapter 1 . 5/5/2003
"That's different," Kaiba said. "When Eminem loses to Yugi, he can use that word. Until then, he can't, and I don't want you hearing it."
"I'm going to beat you, because I AM THE GAME-AH, AND I AM THAT DAMN GOOD!" Yami Yugi shouted. "It's time to d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d..."
"Yugi, are you okay?" Tea asked.
"D-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-d-duel!" Yami Yugi shouted. "Oh, I just love saying that. I think I'll say it again! It's time to-"
"That's terrible, Yugi!" Yugi's grandpa said. "But, uh... if you give me any cards with Carmen Electra's picture on them, I'll forgive you."
What can I say, I'm cracking up! Somebody better spray Yugi's grandpa with hairspray before he goes beserk...


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What to Get the Kids? High Tech Toys that Teach
These days, shopping for Christmas presents for children can be a little overwhelming.
On top of the usual high-demand gadgets like tablets and smartphones, there are dozens of high-tech toys to pick from—battery-operated puppies, motorized wagons and so much more.
But how do you actually pick out toys that have real educational value? Manoush Zomorodi, host and managing editor of WNYC's New Tech City has a few ideas about how to get out of the iPad rut with tech toys that let kids build and create, and not just push buttons.
She shares her list of toys that teach, promote creativity, and build skills, while managing to be fun too.
Below you'll find a list of some of of the toys recommended by Manoush:
-LEGO Mindstorms
-Rainbow Loom
-Marble Run


text:
The Italians know better than anyone how to build an appetite. A little something stiff and bitter, a few salty snacks and we're off to the main event. An apertitivo and an offering of antipasto is intended to build an appetite, not to extinguish it, making room for a primi, secondi, contorni and a little something sweet to finish off the meal. In this class, we will discuss a range of Italian bitters, lay out a beautiful spread of antipasto and then fire up the wood-fired oven for fresh made, thin crust Italian style pizzas. To accompany our meal, we will whip up a crisp bitter green salad and to finish we'll bake off a flavorful almond brandy cake with a light and tender crumb.
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How to create communications objectives from nonprofit strategic goals
Every morning we decide what we're going to do that day. At work, we have more or less a billion projects on the go and our to do list never gets shorter. The only way nonprofits, and staff, don't implode from the workload is by setting and staying focused on priorities. There will always be… Read More »


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Pimples and scars
I habe got small zits kind of pimple on forehead nd cheeks Forehead p it comes and go,but this time its been month till now nt gone Cheecks p i hve very tiny pimples Please help me
Answers (2)
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Dr. Govind Suresh Mittal
Dermatologist 6 yrs exp Bangalore
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Greetings. Acne is a chronic problem. You may need a few medications and lifestyle changes for long term improvement. The following would help you : 1. Daily use of gel based sunscreen in day time of SPF 30 applied half hour before sun exposure to prevent darkening of spots. 2. Daily bed time use of retinoid cream will reduce acne and oiliness 3. Antibiotic agents short course- prescribed by dermatologist for controlling out bursts .salicylic acid based or benzoyl peroxide based face wash for oily skin. 4. Evaluation by dermatologist for any other trigger or need for oral retinoids- this will indeed help but should be taken only if necessary and under monitoring. Also salicylic acid Peel if needed 5. Procedures like microneedling rf, fractional lasers or just microneedling for scars are helpful and necessary. Chemical peels for acne and spots. Using an anti fungal shampoo will be of great help in reducing dandruff and also pimples on forehead 6. Kindly read my blog on daily skin care on Practo health feed. Daily fitness work out and loads of fruits and veggies will help loads in improving your skin. You may Send further queries on private follow up chat. Hope this helps. Warm regards.
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haldi besan lepa first twice a day .second stop all heat producing substances
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Hong Kong must improve innovation and higher education if it is to enhance its global competitiveness, the Geneva-based World Economic Forum warned yesterday.
The non-profit foundation issued the advice in its annual Global Competitiveness Index report, which found that although Hong Kong moved up two places to rank seventh among 148 economies in overall competitiveness, in terms of innovation and business sophistication it was left languishing in 19th spot - trailing both Qatar and Singapore.
The index was formulated by combining 12 categories of 114 indicators, which measure the economies' institutional quality, infrastructure, health, education, market efficiency and innovation. The figures were obtained either from a survey of 13,638 executives around the world or international organisations.
Switzerland, Singapore and Finland remained the top three in terms of overall competitiveness. Mainland China was 29th.
Hong Kong topped the world in terms of infrastructure and financial-market development, with the report praising the "outstanding quality of its facilities across all modes of transportation", the "high level of efficiency, trustworthiness and stability" of the financial system, and the "dynamism and efficiency of the goods and labour market".
But in terms of education and innovation, Hong Kong trailed behind major economies in the region. Hong Kong ranked 23rd in innovation, up three places from last year - but still behind Singapore (9th) and Taiwan (8th). It ranked 22nd in terms of higher education and training, a category in which Singapore ranked second and Taiwan 11th.
"In order to enhance its competitiveness, Hong Kong must improve on higher education and innovation. In the latter category, the quality of research institutions and the limited availability of scientists and engineers remain the two key issues to be addressed," the report says.
Economist David Wong Yau-kar, the chairman of the Business and Professionals Federation think tank, said the ranking reflected the urgent need for a broad strategy to encourage technological innovation.
"Korea, Singapore and Taiwan were successful because they have a grand policy back-up and government investment."
A spokeswoman for the government's Innovation and Technology Commission said it had been "adopting a multi-pronged approach in promoting research and development as well as technology transfer", with HK$314.9 million in research funding provided to five government R&D centres in 2012-13.


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Ontario Woman Charged For Impersonating Mom To Take Driving Test
SMITHS FALLS, Ont. — An Ontario woman is accused of donning a wig and glasses to impersonate her own mother so she could take a driving test on her behalf.
Police in Smiths Falls, Ont., say the test took place on June 9 at the local Ministry of Transportation office.
The driving instructor allegedly grew suspicious of the 39-year-old woman, who was claiming to be 73, and called police.
They say an investigation revealed the woman had dressed herself to resemble her mother.
Police say she was trying to pass the test on her mom's behalf.
The woman, whose name was not released, has been charged with adult personation with intent.
Also On HuffPost:
We begin with a classic. A Maryland teenager snacking on some special brownies in class is approached by his instructor, who requests a sample. Flustered and surprised, the student obliges. Just a few hours later, the teacher is feeling it, and the student is charged with juvenile counts of administering a dangerous substance, assault and reckless endangerment.
Caroline Cartwright, of Sunderland, England, defied a court order requiring her to stop screaming during sex with her husband after police responded to approximately 30 noise complaints at her home. "It's not as if I'm having sex and think 'Oh, I'm making too much noise. I better be quiet,'" she said. Indeed.
Perhaps Ryan Quinn, 19 of Newport, Rhode Island, has a future in NASCAR? For now, he has to deal with reckless driving and two counts of possession of a controlled drug.
Florida woman France Riney, 60, was hit with a DUI charge after she allegedly sat behind the wheel of a parked car and drank vodka while a St. Lucie County sheriff's deputy tried to question her.
A pair of accused shoplifters in Idaho were caught in a loop when they simply drove in circles during their getaway, making it very easy for police to put down spike-strips and deflate the suspects' tires. Better luck next year.
Forty-nine-year-old Steven Mason and his sons, 21-year-old Stephen Mason and 25-year-old Stevin Mason, were accused of beating another man with pipes and a bat after a funeral reception. One can only assume it was a little tricky to keep the names in order for the booking photos.
An 18-year-old girl, arrested for narcotics possession, wanted to make sure her Twitter followers were aware of one thing: "My mugshot's cute."
The masturbating builder was hired over the summer for renovations on a housing estate in Sutton Common, in the United Kingdom. He was caught with his pants down by a surveillance camera set up by the couple who owned the house. Believe it or not, in a play akin to busting Al Capone on tax evasion, the whacking worker was actually fined for stealing a step ladder, rather than the dirty deed.
Apparently, this guy. Robert Durst, a 71-year-old multimillionaire, mind you, was found guilty of dropping his pants and peeing on a candy aisle in a CVS pharmacy. Gross.
If there's any good that could come of your public display of intercourse going very public across the Internet, it would be the honor of our top dumb crime story of 2014! Right? This couple had an especially memorable St. Patrick's Day in Delaware, as police searched for them using this unflattering photograph.


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Kayla: Dreams to Nightmares
As I left the office I looked back at Artemis with a scared expression but I doubt he saw it. The woman, Rose, held firmly onto my arm. She had a strong grip and refused to let me go. She led me to a building and up a flight of stairs. We stopped at the end of the hall in-front of a door with a number 13 painted on it. She took a key out of her pocket and unlocked the door.
"This will be were you will be staying for a long while so try not to wreck anything." She said as I stepped into the room. There were 6 windows in the room with a queen size bed in the left corner with a night stand beside it. There was a dresser and a small closet. It wasn't the biggest room ever but it was small and cozy, and for me perfect.
"Um, okay thanks?" I said as I turned to look Rose. She threw the key at me and I wasn't able to catch it so I made it levitate before hitting the ground then come up and land in my hand.
"Is that your gift?" The woman asked, looking at the key in my hand.
I shrugged and sat on the edge of the bed, "One of them."
She opened her mouth to try and speak but I interrupted her.
"Well I'm tired." I said with a yawn, "G'night."
And with that I made the door shut and lock in her face. I lay down and remembered leaving my suitcase on the beach. I opened a window and thought about my bag and it came in through the window and landed on the floor. I took out my pj shorts and a tank top and put them on. I crawled into the bed and soon fell asleep.
My dreams soon turned to nightmares though and the bright colours turned to darkness. I saw a big, strong man arrive here at the island. He threatened this place and all that were here. I saw many die and many get injured, and I could do nothing. I saw blood and darkness, then nothing-ness. I had died in the nightmare.
I awoke screaming at the top of my lungs. I had an unbearable pain soon take over me and I soon realized it wasn't a dream or a nightmare but a vision. Dammit! I went over to the open window and breathed in the cool night air. The sun was just starting to come up and I needed to tell someone about what I had just seen. I thought about myself on the ground outside my window and sure enough when I opened my eyes I was there. I only knew one person on this island apart from the office lady. I closed my eyes and when I opened them I was in-front of another dorm looking at a window. I lifted myself up to the window and looked inside. Artemis was sound asleep. So being myself I started to tap on his window.


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Cornea Gumbo
Definition - What does Cornea Gumbo mean?
Cornea gumbo is a term in IT for an overly flashy, garish, overstuffed or overstimulating Web page or site. Cornea gumbo pages are a mass of color, shape, image and video that confuses the user.
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Users Who Downloaded This File Also Downloaded
Users who downloaded this file also searched for
leftover / un-used BMX artwork from the 2012 USA BMX T-shirt collection. Free of charge! Created by gOrk.
This work is licensed under a Creative Commons Attribution-Share Alike 3.0 Unported License. You may redistribute, remix, tweak, and build upon this work even for commercial reasons, as long as you credit this artist by linking back and license your new creations under the same terms.View USA-BMX's Portfolio


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Escape From Alcatraz
A great and mysterious prison break-out.
Read Our Full Review & Parent Discussion Questions Here
Escape From Alcatraz
Rating & Content Info
Why is Escape From Alcatraz rated PG? Escape From Alcatraz is rated PG by the MPAA
Violence: A depressed man chops his fingers off with a knife in a prison workshop—we briefly see the act and the dismembered digits on a table. A fight breaks out and a character is stabbed with a knife—some blood is seen. Other scenes include fights, characters making aggressive verbal comments and some pushing and shoving.
Sexual Content: A number of men are seen naked in a shower room—we mostly see them from the rear. A man makes a sexual overture toward another man, who reacts violently.
Language: Three scatological expletives are heard along with two mild profanities, a couple of religious expletives, and racial and sexual slurs.
Alcohol / Drug Use: A character discuses sniffing glue.
Page last updated October 14, 2015
|Rating Descriptor
|British Columbia
|Not Rated
|Not Rated
|Not Suitable For Children.
|Not Rated
|AA (Adult Accompaniment) - Not Recommended for Children
|Not Rated
|Canadian Home Video
NEW: Listen to our Parent Previews Podcast and take control of media and technology in your family!
News About "Escape From Alcatraz"
Cast and Crew
Escape From Alcatraz is directed by Donald Siegel and stars Clint Eastwood, Patrick McGoohan, Roberts Blossom.
Home Video
The most recent home video release of Escape From Alcatraz movie is October 13, 2015. Here are some details…
Home Video Notes: Escape Form Alcatraz
Release Date: 13 October 2015
Escape From Alcatraz releases to home video on October 13, 2015.
Related home video titles:
A group of imprisoned soldiers attempt to breakout in the classic movie, The Great Escape. After WWII, a young boy flees from a Bulgarian prisoner of war camp in I Am David. And Chicken Run spoofs the escape genre.


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Quality Inn & Suites
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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- Suites
- Swimming pool
- Free High-Speed Internet
- Continental Breakfast
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- Swimming pool
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TripAdvisor Reviews Quality Inn & Suites Northampton
Travel Blogs from Northampton
Stockbridge - Norman Rockwell Museum
... of his illustrations was on the front they had to print an extra 259,000, they were so popular. He still is popular judging from the numbers of people at the museum. It was good to see the originals of so many familiar pictures - to see his actual brush strokes. We also heard background stories to some of his paintings. He used the locals as models. One little boy, Billy Piper, was so excited to be ...
Sturbridge to Springfieldwn
... but they turned up at 3.15, unfed and Graeme was hot n sweaty. The museum was almost an all day thing and he spent the last 15 minutes shooting baskets while Graham was videoing him. Very happy hubby. There is a lot he would like to tell you all about it but I'll let him do that himself. Springfield is also the home of Indian motor bikes. It is also the home of Eleanor Powell, the 1930s movie star. So ...
Rain and falling leaves
... not sure why these small towns exist. We are here because they have a motel - admittedly it is not in the town, if you can call it a town centre. However next to the motel there is a Yankee Candle - it is huge - a candle, Christmas, homeware store - they give you a map to find your way around. They even have a restaurant and that is where we had diner - it was great food - they had jazz musicians - and we even received a candle - what more could you want. Mileage: 165 ...
Almost Home. In Massachusetts
Today was a coming home ride from Burlington VT. to Southwick MA. It was a glorious morning and the perfect temperature. Mt Mansfield was shrouded in haze but I could see Camels Hump. Traffic was light on I-89 S. I decided to head to Waterbury VT. and zig zag through the mountains from US 100 over to 116 and back to 100 heading south. The mountain passes were in rough shape. I hope to be able to down load the ...
Van Buren Historic Site and Tolland State Forest,
1. Tolland State Forest, East Otis, MA Site 23 93 sites
This is definitely forest camping on Otis Reservoir, which is a scenic lake peninsula. No hookups and there are only about 25 sites out of 93 for trailers and RV's. Our site was down a long rocky driveway slanted to the lake with a picnic table and firepit overlooking the lake. We could have put ...


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Mobile App
Institute of Business Management & Rural ...
Total Students
Fees Range
How to reach
Institute of Business Management & Rural Development is situated at Vilad Ghat,Vadgaon Gupta, PO MIDC, Ahmednagar, Maharashtra 414111 in Ahmednagar.
Courses Offered
- 2 Years
- Master of Business Administration-M.B.A.
- Management - BBA / MBA / Diploma
- 3 Years
- Master of Computer Application-M.C.A
- Information Technology - BCA / MCA / Computers
Institute of Business Management & Rural Development - IBMRD
The vision of IBMRD is to be the leading centre of learning and innovation in emerging areas of business and management education. For every course the college imparts practical training to its students that helps them to understand better, improve their demonstrative skills, eliminate hesitation and in this process strives to mould them into industry ready professionals. Mission of IBMRD is 'to foster critical analysis by training students both in theory and practice so as to equip them with skills needed for facing global challenges with team work and human values. And to build quality network with the Industry, educationists and the society for exchanging knowledge'. The modern teaching methodology assists the students in getting an all around view of engineering, technology and the entrepreneur world. The diligent faculty team of the college possesses hands-on experience and up to date knowledge of their subject and area of expertise. The infrastructure and facilities of IBMRD consists of spread-out campus alongside various amenities in the form of library, computer center, classrooms with proper teaching and learning aids, medical facilities etc. The institute seeks to place each of its students in an organization/company of great repute.
Why join IBMRD
This institution's rich nostalgic past, is a saga of dedication to the cause of education.
2 Type Courses Available
- 2 PG Courses
Institute of Business Management & Rural Development Placements
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Student Placement
This college is like an Oasis in the Desert. The teachers of this college are well reputed in their field and are pious mission to inoculate the air of dynamism among the students who are mostly from weaker section. Large numbers of alumna and alumnus from this college are working in the reputed fields in Government and Corporate sectors.
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Some Workers Still Hospitalized After Tyson Chlorine AccidentJun 29, 2011 | Parker Waichman LLP
Investigators in Arkansas are still trying to determine what led to a chlorine leak at the Tyson Foods Plant in Springdale, Arkansas on Monday. Tyson Foods has blamed the accident on "human error" which resulted in the accidental mixing of two chemicals, but the company isn't saying much else.
Initially, 173 of roughly 300 workers evacuated from the Tyson Foods facility were sent to area hospitals after complaining of respiratory problems hospitalizied. As of today, 14 remain hospitalized, with one still in ICU.
According to local media reports, the chlorine fumes were first noticed Monday morning in an area of the plant where chickens are cleaned. A hazmat team was called to the scene, and the Fayetteville Fire Department had to set up a decontamination tent at Washington Regional Medical center to aid patients from the Tyson leak.
At a news conference yesterday, Tyson officials said a health clinic will be set up at the plant to provide follow-up medical attention for employees who return back to work over the next several days. Anyone who did not receive a medical evaluation after the accident on Monday will be able to undergo one there.
Tyson said it will not comment further on the accident until its own investigation is complete.


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Snowboarding Forum - Snowboard Enthusiast Forums (http://www.snowboardingforum.com/forum.php)
- Bindings (http://www.snowboardingforum.com/bindings/)
- - Will Switchback Straps and Highbacks work with my bindings? (http://www.snowboardingforum.com/bindings/124145-will-switchback-straps-highbacks-work-my.html)
Will Switchback Straps and Highbacks work with my bindings?
Just bought the Salomon quantums. I usually try to keep my bindings for a long time but usually the ladders and ratchets get messed up after a while. I called the Salomon warranty number asking them if i can buy extra ones while they still have them lying around and they said that i have to ask the online retailer i bought it from instead because they sometimes send them extras.
So.... i called Evo and they said they don't have any extra parts for bindings at all. They said they usually can only kickstart the warranty process if your binding parts are actually broken in which case they contact a private warranty department of Salomon which I'm not allowed to get ahold of.
Anyways, has anyone tried mix matching straps and parts of different bindings?
I'm wondering in particular if the switchback straps will fit my Salomon quantums.
The ankle strap seems like it probably wouldn't be an issue, but the toe ladders seem kinda particular. They pop out from the bottom like other bindings but they have metal nubs that lock in instead of plastic ones.
Also, the Switchback highbacks look like they attach to the bindings in the same location as the Shadowfit bindings. This way i can probably switch out the stiff carbon highback for a softer one when i'm normally riding in the park.
If no one's already tried this, i might give it a shot.
I'm skeptical, but give it a shot. At least you can buy the switchback base plates afterwards and BOOM you're back in business.
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Hello Jyoti,Good to hear that you have decided to go for IFS (Indian Foreign service) officer. This is a very prestigious job considered in the society.The Indian Foreign Service is a Central Service and premier diplomatic service of our country.Members of the IFS,primarily represent the country in the international arena.The Indian Foreign Service deals with the countries external affairs including diplomacy and cultural affairs.It is responsible for the administration and activities of Indian Missions abroad, and for the framing and implementation of the governments foreign policy. An IFS officer can be posted 160 odd Embassies and Missions abroad. They can be deputed to institutions like United Nations,UNESCO,World Bank,SAARC etc. Back Home,they can be posted in various parts of the country as passport officers.ELIGIBILITY :Age-Candidate should be between 21-30 years of age as on 1st august of the year of examination. Maximum 30 for general category,33 for OBC and 35 for SC/ST.EDUCATIONAL QUALIFICATION-Candidates are required to have degree or equivalent qualification from a recognized university .Candidates appearing at their degree examination with prescribed subjects are also eligible to compete.NATIONALITY:1.A citizen of INDIA or;2.subject of Nepal or;3.subject of Bhutan or;4.a Tibetan refugee who came to India before 1st January 1962 with intention to permanently settle in India.In order to apply for this exam one has to apply online on UPSC website: www.upsconline.nic.in.Registeration for the exam is Rs.100 which can be deposited in State Bank of India or paid through net banking.EXAM PATTERN:The Indian Foreign Service Examination consist of two successive stages:1. Civil Services (Preliminary) Examination(Objective Type) CSAT for the selection of candidates for the Indian Foreign Service (Main)Examination.2.Main Exam -a written test and than an Interview.Prelim EXAM PATTERN:1. General Studies (GS) -200 marks- 2 hours (1/3rd of marks alloted for negative marking for every question.2.Civil Service Aptitude Test( CSAT)-200 marks- 2 hours(1/3rd of marks alloted for negative marking for every question).Main Exam:There is no negative marking as it is a descriptive paper.WEBSITE:www.upsc.gov.in (official website)There has been a tremendous demand in this filed due to the Globalisation.Hope you find this information useful and helpful.Feel free to get in touch.Wish you Good LuckWarm Regards,Prathamesh K.
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Founder And Director At Canvas Career
Mr. Prathamesh is a Certified Career Consultant by Psytech International (bps) UK and is also a Certified Trainer for Life Skills; he is pursuing Narrative Therapy from Adelaide, Australia. He has been in to career counseling for more than 8 years now he practices MINDFULNESS psychotherapy with students. He possesses vast experience in teaching and career counseling. Currently he is associated with FUEL NGO. He had counseled over laces of students and is a founder director of Canvas Career Consultancy, committed to conduct Psychometric assessments for students and do career counseling by making them aware about new career avenues
FreeLancer Academic and Career Guidance Counsellor
Mrs. Halima is a postgraduate in psychology from Osmania University and a International Diploma in Guidance & Counseling in collaboration with COL, Canada. She posses Enormous experience in Academic and Psychological Counseling and had done Project on "Counseling & Guidance using ACA & APA standards ", "Motivation to enhance academic achievements"," Comparative analysis of Self Confidence of undergraduate boys & girls". She had worked as an Academic Research Associate at Indian Institute of Management, Indore. She specializes in educational, career and academic counseling and guidance, Organizational behavior.
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Dr. K.V Anand is a PhD in Counseling Psychology from Fort Jones University USA with MSc In Applied Psychology and MS in Psychotherapy. He is an expert in psychometric tests to facilitate awareness about various psychological traits, personality, skills, aptitude etc. He is a Certified Motivation trainer and personality development trainer. He is experienced in evaluating of psychology or psychiatry cases. Uses Psychometric tests such as personality, bipolar disorder test evaluation, student counseling. He has more than 9 years experience in soft skill training field covering career guidance, education, motivation, personality development, team building, leadership skills, stress management, conflict management, decision making. Beside this he is a active writer and have books related to psychology under his name such as "Adolescence mental Problems" and "Infant and Child Psychology"
Founder & CEO: Discovering Careers India
Dr. Anand has 10+ yrs experience in education and financial sector, 12+ yrs into writing articles and books. He advises on Finance, Banking, Management, Commerce, Engineering, Education. B.Com, M.A. Economics, PGDFB (SIBM), DIT, Ph.D (Education Economics)
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