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Fifty years since the discovery of ibuprofen
- First Online:
DOI: 10.1007/s10787-011-0103-7
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- Rainsford, K.D. Inflammopharmacol (2011) 19: 293. doi:10.1007/s10787-011-0103-7
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This remarkable discovery was undertaken under what by present day standards that are rather basic laboratory conditions and without much knowledge of the mechanisms of inflammation and biochemical targets to use for drug actions. The discovery of ibuprofen was essentially made on an empirical basis. Indeed, there were many the twists and turns that took place during the discovery and development of ibuprofen from initial humble beginnings. It was only in the early 1970s that the actions of prostaglandins and their actions were established in mediating and regulating inflammation. It took longer still before assays for detecting anti-inflammatory activity based on prostaglandin synthesis inhibition were developed, as well as for the conditions for suitable assays understood, refined and validated for screening potential druggable agents.
It is a great tribute to Dr. (now Professor) Stewart Adams and his colleagues that was through their insight and persistence which enabled the pharmacological activities of ibuprofen to be discovered and the clinical potential to be realized at a time when little was known about techniques for quantifying clinical responses in arthritic and other painful inflammatory conditions.
Summary of the history of the discovery of ibuprofen at the Boots co., and subsequent worldwide development
Stewart Adams plans search for replacement for aspirin
Development of guinea pig UV erythema as a potential screening assay for new compounds with anti-inflammatory activity
Initiation of chemical development programme by the late Dr John Nicholson. Initially, screening of >200 salicylate compounds—proved no better than aspirin (Adams and Cobb 1967)
Phenoxy-acid, RD 8402, in clinical trial. New strategy: search for analgesic and antipyretic with anti-inflammatory activity
Phenyl acetic acid, RD 10355, active in clinical trials in RA, but rash in 5/12 patients led to it being abandoned.
Anti-erythemic activity of ibuprofen discovered. UK Patent application February 1961; final specification September 30, 1964.
Iso-butyl-phenyl acetate, Ibufenac, active clinically in RA, with no rash. In 1968, withdrawn in UK because of liver toxicity, but this was not found in Japanese patients. Liver toxicity related to accumulation of radiolabelled drug in liver.
Ibuprofen, a phenyl propionic acid, made product candidate: Compared with aspirin 16–32× more potent as anti-inflammatory, 30× more potent as analgesic (Randall Selitto assay) and 20× more potent as antipyretic. Little accumulation of radiolabelled ibuprofen and low GI toxicity in dogs.
1969 (February)
Ibuprofen launched in UK as Brufen®
First Symposium on Ibuprofen at Royal College of Physicians, London
Ibuprofen developed as product candidate in 1967 by Upjohn Co. (USA) approved by FDA and launched in USA as Motrin®
Ibuprofen approved by the UK CSM for Over the Counter (OTC, or non-prescription) sale. Launched by Crookes Products Ltd (Boots subsidiary) as Nurofen® August 8, 1983
Ibuprofen approved by US FDA for OTC sale on grounds of proven gastric safety. Whitehall Laboratories (Division of American Home Products) by arrangement with Boots, later marketed ibuprofen as Advil®
Present day
OTC ibuprofen approved for marketing in 82 countries
The occurrence of liver toxicity led to efforts to establish if this was due to accumulation of the drug in the liver. Use of radiolabelled drugs, ibuprofen, it was found that this drug did not accumulate to the extent that was observed with ibufenac. With attention to the pharmacokinetics, gastro-intestinal and liver toxicity, ibuprofen was selected after an extensive programme of drug screening. It may not have been the most potent of the drugs evaluated but it had low toxicity. The recognition since that short half-life NSAIDs with little propensity to accumulate systemically has formed a basis for recognizing the safety of these drugs over those with longer half-lives or accumulation in key organs where untoward reactions may develop (Adams 1988). Indeed, subsequent evaluations have shown that the specific accumulation and persistence of some NSAIDs in their sites of action (i.e. "effect" compartment such as inflamed tissues) relative to their fast clearance from those organs ("side-effect compartments", such as the blood, kidneys and liver) in which toxic reactions may occur with the NSAIDs may explain their relatively low propensity for adverse reactions from drugs like ibuprofen especially at low over-the-counter (OTC) doses (Brune 2007). These investigations have proven an important basis for what is known today about the relative safety of ibuprofen.
The early clinical studies with ibuprofen in rheumatic patients were undertaken with cautious approach to dosage (Rainsford 1999). Safety data became available from some 19,000 patients and this was presented to the UK CSM in support of the case for non-prescription use of ibuprofen. Subsequently, the acceptance of its relative safety led to approval by the UK authorities in 1983 and in 1984 in the USA of low dose (<1,200 mg/day) for non-prescription OTC sale direct to the public. In addition to its wide availability as an OTC analgesic, ibuprofen is now widely used in many countries, often as a first line treatment for the relief of symptoms of pain, inflammation and fever at both prescription as well as non-prescription dosage.
In the recent years, a large number of mega-trials in the recent years have focussed on the clinical uses, safety and pharmacological properties of ibuprofen given at prescription level doses (<2,400 mg/day) compared with newer NSAIDs (including coxibs). In many of these studies, ibuprofen was used as the reference drug in view of its established safety and efficacy. These studies have shown that ibuprofen has comparable safety and efficacy with that of the newer drugs, for long-term usage (6+ months).
Spontaneous reports of adverse events and adverse drug reactions (ADRs) in clinical trails from long-term coxib comparator studies as well as in epidemiological studies show that ibuprofen has relatively low risks for gastro-intestinal (GI), hepato-renal and other rarer ADRs compared with other NSAIDs and coxibs (Kean et al. 2008; Rainsford et al. 2008; Rainsford 2009). A relatively low risk of cardiovascular (CV) events has been reported in some, not in all studies, but the risks are in general lower than with some coxibs and diclofenac (Psaty and Furberg 2005; Topol 2005; Antman et al. 2007; Purcell 2007; Strand 2007; Trelle et al. 2011). The possibility that ibuprofen may interfere with the anti-platelet effects of aspirin, though possibly of limited significance, has given rise to caution on its use in patients that are at risk for CV conditions that take aspirin for preventing these conditions (Cryer et al. 2005: Rainsford 2009).
In addition to ibuprofen having unique pharmacokinetics, it also has a broad spectrum of actions on different inflammatory pathways, aside from its affects on pathways of prostaglandin metabolism (Rainsford 2009). This may also be of considerable significance for the actions of the drug in relation to controlling inflammation but also it has relatively low toxicity. The diversity of non-prostaglandin mechanisms, by which, ibuprofen controls inflammation may reduce the dependency on prostaglandin inhibition for controlling inflammation, so achieving a greater overall balance of the regulation of different pathways and mediators of inflammation. The impact of this may be that the relatively low requirement for inhibiting prostaglandin production may reduce the risks of prostaglandin-related side effects (Rainsford 2003).
Since its initial discovery, ibuprofen has been developed in a wide variety of oral and parenteral formulations for use in a variety of indications (Higton 1999; Massey et al. 2010).
In the past decade or so there has been much commercial and clinical interest in developing and use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine, caffeine) (Rainsford 2012). The objective of many drug combinations has been to raise the "analgesic ceiling" to achieve greater or more sustained acute pain relief. While in many cases the "jury may still be out" on most of these claims, there are already some indications of some potential therapeutic benefits of the drug combinations in certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). Further investigations of these ibuprofen–drug mixtures may be required to establish optimal conditions for their uses in various indications as well as their relative safety.
Paediatric use of has shown that the drug is relatively safe especially in comparison with paracetamol, and effective as a treatment of acute pain and fever. In some conditions ibuprofen is probably more effective than paracetamol as an antipyretic and analgesic (Beaver 2003; Rainsford 2009; Sullivan and Farrar 2011). A recent clinical assessment of antipyretic use in children showed there are no substantial differences in the safety and efficacy of ibuprofen and paracetamol in the care of a generally healthy child with fever (Sullivan and Farrar 2011). Although hepatotoxicity is reported rarely with paracetamol at recommended doses, there is a concern when there has been overdose. Ibuprofen appears to have longer clinical effect in reducing elevated temperatures than paracetamol (Sullivan and Farrar 2011). Nephrotoxicity with ibuprofen has been reported to be a concern in children with febrile illnesses (Sullivan and Farrar 2011) and the general advice is to watch for dehydration and ensure that patients receive adequate fluids.
At OTC doses (<1,200 mg/day) ibuprofen has a comparable safety profile with that of paracetamol. Its anti-inflammatory activity is linked to its analgesic effects and this is related to reduction in the ex vivo production in blood of cyclo-oxygenase (COX)-1- and COX-2-derived prostanoids (Blain et al. 2002; Rainsford 2009). Ibuprofen at OTC doses has low possibilities of serious GI events, and little prospect of developing renal and associated CV events. Ibuprofen OTC does not represent a risk for developing liver injury especially the irreversible liver damage observed with paracetamol and the occasional liver reactions from aspirin (Rainsford 2009). One of the successes with ibuprofen since its introduction in a low dose (≤1,200 mg/day) for OTC use that it has proven relatively safe and effective such that it is now licensed and available in over 80 countries worldwide.
Large-scale clinical and epidemiological studies have shown that ibuprofen OTC is safe, especially in the GI tract than aspirin, and has similar GI safety compared with paracetamol (acetaminophen), yet without the risks of liver toxicity seen with the latter drug (Rainsford 2009). This is not to say that OTC ibuprofen is without adverse effects. However, the occurrence of these untoward actions is rare and well understood and most reactions are reversible upon cessation of the drug (indicating reversibility of toxic mechanisms) (Volans et al. 2003).
Research on the diverse pharmacological properties of ibuprofen, like that of some other NSAIDs, has advanced in parallel with understanding of the cell and molecular biology of inflammatory processes, especially those underlying neuro-pathological reactions in pain and neurodegenerative diseases (Townsend and Praticò 2005; Kotilinek et al. 2008) and cancer-related inflammatory reactions (Wynne and Djakiew 2010; Greenspan et al. 2011; Woodman et al. 2011). Consequently, more interest has been shown in the past two decades or so in the potential for ibuprofen to prevent conditions such as Alzheimer's and atherosclerotic dementias, Parkinson's disease and nerve injuries (Townsend and Praticò 2005; Hirohata et al. 2008; Kotilinek et al. 2008), as well as colo-rectal, mammary, prostate and some other cancers (Harris 2002; Rostrom et al. 2007; Brasky et al. 2010, 2011; Mahmud et al. 2011). While these developments are undoubtedly exciting, there will, however, extensive investigations which will have to be performed to understand when ibuprofen should be employed in the various stages of these chronic and complex conditions and at what dose(s). Indeed, special formulations of ibuprofen may need to be developed to ensure optimal biodisposition of the drug (e.g. localized delivery in the colon in colo-rectal cancer) or prolonged pharmacokinetics for specific applications in different chronic diseases (e.g. in cystic fibrosis) or special patient groups (young and the elderly) whose long-term safe use is required (Rainsford 2012). The extensive interest on the effects of ibuprofen in these non-pain conditions attests to the diversity of the pharmacological effects of ibuprofen as well as differences in comparison with other NSAIDs.
Over the years since the introduction of ibuprofen, it has withstood competition from newer NSAIDs and paracetamol and commands a place in the mainstay of therapy for pain and inflammation. Moreover, there have been a considerable number of NSAIDs that have been withdrawn since the development of this class of drugs from the 1970s (Rainsford 1987) and more recently with some of the coxibs (Topol 2005). It is, therefore, notable that ibuprofen has survived where other drugs have failed and been a leading drug for the relief of symptoms of mild-to-moderate pain in various arthritic and other chronic inflammatory conditions where it has been used as a prescription drug and the relief of various inflammatory pain conditions at OTC doses.


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Saturday, September 13, 2008
What A Swell Party We Had!
A very special thanks to our gracious hosts Bob and Eudice Fogel for inviting us into their lovely home and to Peg Roth, our former 43rd Ward Democratic Committeeman, who served as Honorary Co-Chair of the event. Stunning floral arrangements were provided by Dilly Lily - one of our local 43rd Ward businesses.
Many of our local elected officials served as hosts along with numerous friends in the 43rd Ward community. Please take a moment to look at our Unity Event Photos to see the full range of our 150 attendees.
This is a tremendously important time for the Democratic Party, including those of us in the 43rd Ward. The success of our Fundraiser makes it possible for us to continue organizing for the November election. It ensures that we will be able to continue our voter registration drive and implement a precinct operation that will turn out the vote in November. It means continuing to make phone calls and making trips to Michigan to turn out the vote there for Barack Obama. It means we can truly make a difference in this most important race for the White House.
That's why we came together for this Unity Event and that's where you can help. To volunteer in the election effort please contact me at firstname.lastname@example.com.
Sunday, September 7, 2008
Live From The Democratic Convention!
Desperately Seeking Credentials, or Networking Gone Wild!
I arrived in Denver early Monday after only a few hours sleep. After dropping off my suitcase, I spent the day with a friend who is a veteran of conventions. First order of business? Get me a credential so that I can watch the convention tonight!
As I am not a delegate, I have to get new credentials every day of the convention. My experienced friend said to get credentials we have to talk with everyone who might have access to them - party officials, large contributors, and political figures and see if any of them has an extra.
The Illinois Democratic Party is having a lottery to allocate their excess credentials. I put my name in, and we move on. Along the way, I chat with all the people I know - in no particular order, Com. Mike Quigley, State Rep. John Fritchey, Peg Roth, State Sen. Kwame Raoul, my old collegue from the U.S. Attorney's Office Sheldon Zenner, Debra Shore, Jesse White, Jesse Jackson, Jr., Ald. Bob Fioretti, Ald. Danny Solis, Rep. Luis Guitierrez, Sandye Jackson, and many more. We took off for the Ritz, then the Hyatt, the Comfort Inn, back to the Marriott, back to the Hyatt. . .
Finally, about 3:00, credentials appear for me. I'm an "honored guest" of the Democratic National Committee. But boy do my feet hurt!
Finally, we entered the Pepsi Center - and bedlam. My so-called "honored guest" passes were great, but by the time we got there, the place was well over capacity. Up in the bleachers, we were urged to sit on the floor of what I believe was a maintenance catwalk, with nothing more than a 2 foot railing separating us from a long drop to the convention floor. Finally, after a stint of sitting on the steps of the balcony, a seat opened up, and I got a bird's eye view of a magnificent speech by Edward Kennedy, with a full demonstration of support by the crowds of delegates on the arena floor.
Later, we got into a skybox (free hotdogs) to watch Michelle Obama deliver a speech that the delegates on the floor carefully listened to, and enthusically endorsed. Spirits are high.
Day Two:
Women's Day
I thought I had a source of credentials for the day, so I decided to take in a few of these meetings. First up - the Women's Caucus of the Democratic Party. Not truly a meeting, the caucus was a rally of about a thousand women, listening to many prominent Democratic women, including for example, the President of Planned Parenthood, officials of the Democratic Party, and a few television celebrities - Eva Longoria ("Desparate Housewives" and Fran Dresser ("The Nanny") - who are both active in women's issues.
Frankly, after a while the speeches seemed sort of the same ("We need change! We need Barack Obama!) while the spectators cheered and shook tamborines (furnished on each chair courtesy of Lifetime Television). But I sat up straight and listened to businesswoman Sheila Johnson, one of the founders of BET, as she called it straight on the issues of race, sex and age in this campaign. "Women hate negative campaigning . . . We have the power to bring back honor the political process." After dropping in for a buffet by another organization, I moved on to the main women's event of the day - a rally sponsored by Emily's List.
Again - thousands of women in a room (no chairs!), with speeches from incredible women. My favorite - Barbara Mikulski, the first woman elected to the Senate without inheriting the seat from a husband. I remember Barbara Mikulski as a Congressman in 1974, when I was a student intern on the House Subcommittee on the Environment. Mikulski worked hard on those issues, and then walked down the hall to serve on the House Judiciary Committee to impeach President Nixon. She is fiery and passionate. She is very very short and well, stout. She said when she decided to run, she was told "This isn't the way a Senator looks." Well, she remarked, this IS the way a Senator looks. The crowd cheered, and I felt better.
When Hillary Clinton appeared, the place erupted. Ellen Malcolm, the founder of Emily's List, was a chair of the Clinton Campaign, and had already made a passionate endorsement of Barack Obama. Hillary, in a preview of her speech last night, told the crowd "all the hours of work and doors you knocked for me, I want you to do the same for Barack Obama."
The Emily's List event ended at four. I walked back to the Marriott to drop off the buttons, pamphlets and posters accumulated during the day and then marched off to the Denver Performing Arts Center for a reception hosted by Mayor Daley. By the time I got there, the food was all gone (and that reception started at 4:00). But I ran into more people I knew - Aldermen Richard Munoz (nursing a broken foot), Bob Fioretti, State Rep. Barbara Currie, former State Rep. Judy Erwin, and many others.
To avoid a repeat of Monday, many left early to trek over to the Pepsi Center and get in line, where I met Sun-Times columnist Lynn Sweet. And then onto the convention and that great speech by Hillary Clinton. We have to get Barack Obama elected.
Day Three:
All Politics is Local
I haven't yet reported that each day of the convention starts with a breakfast for the Illinois delegates and an hourlong meeting, chaired by Mayor Daley. The Mayor and others address the delegates and the rest of us "hanger-oners" watch or kibbutz in the back of the room.
But today was an amazing experience. We heard from Senator Durbin, Congressmen Bobby Rush (recovering from cancer), Danny Davis (who represents part of the 43rd Ward), Governor Blagovich and finally, Congressman Jesse Jackson, Jr.
As everybody knows, politics down in Springfield are - well - complicated. And troublesome right now. The message of every speaker on the panel was unity - between Hillary and Barack delegates, and among Illinois politicians.
I wish I could report all the terrific remarks and stories. I admire a good political speech and today was filled with them. But Jesse Jackson, Jr. topped it off. You may have already read reports about this in the papers or on the evening news.
Frankly, part of the reason I came to the convention was to meet many people I had not had the opportunity to meet. Rep. Danny Davis graciously spent a few minutes with this newcomer, and I have chatted with a large array of local Democrats (many from the Ward) - Marilyn Katz, Cynthia Kobel, Aldermen Tom Tunney and Joe Moore, Water Commissioner Patricia Horton, and many others.
But I was most amazed by the young reporter I met while talking to someone. He mentioned that he lived in the Ward, and finally admitted that he was a high school student from Lincoln Park High School covering the convention for Pioneer Press. I was so proud - I invited him to our 43rd Ward event on September 4.
I don't mean just on the convention floor - I mean everywhere. Speaker Madigan hosted a reception for Illinoisians at Coors Field. There was more food and drink that I can imagine. Buses to the event from the hotel were sponsored by Peabody Coal Company. Thought you would like to know.
And I just got back from the Illinois delegation's party sponsored by Speaker Jones, State Senator Mattie Hunter (who represents part of the 43rd Ward), and others. I was so fired up from the proceedings on the floor tonight - incredible speeches by President Clinton, Joe Biden and the roll call - that I just wasn't tired.
Day Four:
From the Precinct, to the Ward, to the Nation
Attending this convention has benefited our Ward in so many ways - I have met public officials who are interested in our ward, and met fellow Democrats from whom I am learning.
But more directly, after the morning Illinois caucus, I stopped in for a seminar called "Precinct First" for a seminar on precinct organizing. Here were some progressive Democrats from Denver, teaching a Chicagoan how to organize a precinct. Of course, we think we know it all, but these guys are organizing precincts in places you can hardly find a Democrat. I picked up some nice materials that I'm sure we'll incorporate into our precinct organizing training.
In a terrific turn of credential olympics, my friend Mary gave me her "special guest" credential while she got a better one. That allowed me to sit in the 100 section of Invesco Field, which if you know football stadiums, is right below the skyboxes. The rest of the day was spent getting to and attending the incredible day at the stadium. We took shuttle buses from downtown. People with community credentials (that is, public tickets) were not allowed on the shuttle buses and had to walk from public transportation (like parking at McCormick Place for a Bears game).
Mary and I stood in line behind State Rep. Barbara Flynn Currie and State Senator Julie Hamos, and it took us a long while to realize that we were standing behind actress Jorja Fox, who is on CSI and played Secret Service Agent Gina Toscano on the West Wing (you know, the one who protected Zoe Barlett). I had to take a picture.
When we arrived, we learned Congressman Jan Shakowsky had already spoken. Then followed a succession of Colorado politicians, a salute to Martin Luther King (yesterday was the anniversary of his "I Have a Dream" speech), and many many other politicians and musical interludes - Sheryl Crow and Stevie Wonder each did two numbers. But most remarkable was the text messaging. The Obama campaign asked people to text in their name and city and flashed them on the screen (did anyone see the "43rd Ward Democrats - Chicago" that I texted?). What a tremendous strategy - they collected 30,000 text messages - meaning 30,000 cell phone numbers for the campaign.
At a couple of points, teams of orange t-shirted volunteers appeared in the aisles, distributing the American flags and posters that you saw being waved.
As I watched speech after speech from politicians local and national, some that were terrific and others not-quite-so and then heard the combative and moving speech by our nominee, Barack Obama, I realized that every person on that stage was just a person, an ordinary person, who for some reason wanted to do something, make a difference. I hope I can, too.

subset: commoncrawl


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ED Magedson – Founder
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Dereck England1040 County Road 770 Natalia, Texas U.S.A.
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New Shanghai pilot free-trade-zone policies create favourable business environment - .PDF file.
The Shanghai pilot free-trade zone (SHFTZ) was officially established on 29 September 2013. Its launch is set to bring great business opportunities for both foreign and domestic investors in relation to their inbound and outbound investments. The Chinese authorities have issued various regulations and rules to formulate the detailed policies to be applied in the SHFTZ. Minter Ellison discusses the key developments.
The core content of the innovation within the SHFTZ relates to reform in the financial area. We are pleased to see some of the long-awaited financial policies being tried and implemented in the SHFTZ…
If you are registered and logged in to the site, click on the link below to read the rest of the Minter Ellison briefing. If not, please register or sign in with your details below.


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The exotic look of python embossing adds bold texture to this sophisticated leather wristlet. With a fabric-lined interior that holds all the essentials, the zip-top design can be worn on the wrist or tucked into a larger handbag.
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Reed tells a story...
Reedren leaned against the table, looking all the world like a young man trying to share highly technical concepts with a child. "You have coffee?" he asked, the faintest tinge of hope touching his voice.
Deborah nodded slowly and turned to the coffee-maker. She poured a cup and held it out to Reedren, who politely nodded. "Seven sugar, please."
"Seven? " Deborah stammered, but turned to the cupboard. "Um... sorry. No Sugar. Do you want Sweet & Low?"
"What is that?"
"Artificial sweetener. Aspartane, I think. "
"Black, then."
Reedren took the preferred mug. He lingered over the mug, closed his eyes and inhaled. "There is nothing like coffee on the other side. Sahlab doesn't come close."
Lily smiled up at Reedren. "I like Sahlab." She reached her arms out to her mother, who picked her up. Deborah felt herself begin to sob with the sheer joy of Lily's presence, then calmed herself. "You were talking about the Seasons." She ventured tentatively, one arm protectively around Lily, the other clutching the counter-top.
"The Seasons..." Reedren began, "The seasons are an eternal dance. The courts take turns ruling the realms, fae and mortal, yin and yang, if you will. It has always been so, and it keeps the worlds in balance. But it isn't always polite. Sometimes it is bloody and vicious. There have been changes in the courts, recently. And with new blood comes new politics. The courts are unstable."
"Once upon a time, a beautiful lady ascended to the Summer court. She was fair and lithe and danced every morning and every night. The story goes that she had been captured dancing in the moonlight by a mortal who--of course--fell in love with her. She bore him daughter and they lived happily, though she desperately wished to dance under the summer trees once again. "
"She's pretty." Lily said. "She has green eyes like Daddy's."
Reedren continued, "A Summer Hunters found her with her child. She was compelled to dance again. Lady Verano insists she did not love her husband, but that she was bound to stay with him. Truthfully, her husbands' love for her was strong, but the Hunter severed the tie and orphaned the child, freeing Verano of mortal binds. Since then, Lady Verano has ordered the slip for hundreds of mortal children. She seeks one that carries her blood.
"Why?" Deborah asked.
"I do not know the answer to this." Reedren shrugged. "Perhaps she wishes to reclaim some semblance of her love. Or, perhaps she seeks to distill her power by removing any diluted influence."
Deborah gasped despite herself. Reedren glanced down sadly at Lily, and reached a hand out to smooth a strand of hair from her forehead. Deborah pulled Lily away from his reach.
"The Winter Queens hoped she would grow out of this childish obsession. Now, Summer is glutted with Changelings. Winter has forced the issue, claiming tithe to balance. Summer is in full power now, so close to the Solstice, but as Summers' power wanes, the Winter Court will press its' claim. Unless the changelings are cast out from Summer, there will be war."
"The choices for your child were to be cast out without guidance, to be tithed to Winter or to be sacrificed on the altar of seasons. I..." Reedren stopped and took a heavy pull from the coffee. "I will not let these things happen to her. I forged another choice."
Deborah stood, frowning. "Why?" She asked. "Why forge this other choice and bring her back to me? You still haven't said."
Reedren bestowed upon her such a look of tenderness, that Deborah was honestly confused. "Mrs. Samson." he said. "Lily is of Verano's blood."


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Compact handguns are a hard gun to learn on so be patient. They lack the mass for recoil control, have a short sight radius, and some are finicky about ammo. Take your time, be safe, and enjoy that fine firearm!
This is a discussion on New Shooter at the range with my XDm 9mm Compact... within the General Firearm Discussion forums, part of the Related Topics category; Me and the wife went to the range today and shot 100 rounds of 115 Remington FMJ, 50 rounds of 115 Federal FMJ, and 20 ...
Me and the wife went to the range today and shot 100 rounds of 115 Remington FMJ, 50 rounds of 115 Federal FMJ, and 20 rounds Federal 124 JHPs.
The range we visited did not allow vertical targets, which I found odd. Also, they did not allow rapid fire, so this review is off 3 second rounds. I was not happy about this but I was already there and went through with it.
I feel like I shoot better with the compact magazine, the weight of the full extended magazine and undoubtedly my new shooter grip of death, makes it feel loose. So its ironic I prefer to shoot with the small magazine.
My wife also preferred the small magazine, she shot well at 7 yards but only got about 50% on the paper at 15 yards. We both were too all over the place to say this gun shoots high/low/left/right. We both felt this gun/grip worked the best for the both of us.
I had one Malfunction, exactly what happened I am unsure, I pulled the trigger and it went click, so I just assumed the slide didn't lock back so when I pulled the slide back out came a casing and a round. Could have been a limp wrist or just a fluke, but it did happen. I am going to run another 100 rounds this coming weekend to help build my confidence that it won't Mal again. Maybe as a new shooter I am over reacting?
Also, reassembling after cleaning the recoil/spring mechanism kept protruding about a 1/4" from the muzzle upon locking the slide back on, after about the 5th time of reseting the barrel/recoil spring it finally went back to normal, maybe I didn't have it seated "just right."
So theres a new shooters perspective.
Compact handguns are a hard gun to learn on so be patient. They lack the mass for recoil control, have a short sight radius, and some are finicky about ammo. Take your time, be safe, and enjoy that fine firearm!
Last edited by Rightwing; January 16th, 2011 at 05:14 PM.
"You don't have a soul, you are a soul. You have a body." CS Lewis
S&W .41 Mag - Colt DS - Ruger Single Six - Ruger Security Six - Buckmark-Beretta 21A - S&W 351PD 22 Mag- Spfld XD 9mm -- Plenty Of Long Guns--- Dry Powder and RCBS.
Thank you for posting your experience. It is always refreshing to hear a perspective from someone new. I can relate alot from some of the things you stated, as I look back on when I first started. If I may make a suggestion, in the future I would limit my distance to 7 yards, and concentrate on slow fire. Work on the basics of site alignment and trigger control for each shot. Do not worry about rapid fire, that will come on its own. You will progress much faster and be a much better shot by always concentrating on the basics. Also, when the gun goes off, it should be a complete suprise. A slow steady squeeze while keeping the sites on target is the key to this. If you are suprised when the gun goes off during this process, you will be rewarded by a grouping of holes on paper, and thats how you know you are on the right track. Welcome to the forum, and keep shooting.
Thanks for the advice, I will take it and utilize it. SO am I over reacting on the one malfunction I had?
Yeah I immediatly pushed it back in the magazine and fired it off and it fired fine. I tossed all the casings after the shoot though, didn't think to keep them.
Just wondering Druff. Is your pistol an XDm 3.8 compact? In the 2011 edition of The Complete Book of Handguns, Massad Ayoob has a nice gun review on this pistol. He mentions the "stand off" design whereby "the recoil spring guide rod guide protrudes very slightly from under the muzzle. This will be the first contact point against the opponents body ...". This would allow for an extremely close range body shot without any contact taking the gun out of battery. Just a thought. Maybe that is what you were experiencing with your pistol? I'm also thinking about purchasing one this year.
Yes it is the 3.8 XDM 9mm Compact. I wanted something I could learn on, the wife would also feel comfortable learning on, and something I can eventually Carry. She has small hands and I have large, so the interchangeable back-straps made sense and fit us the best. And Springfield is known for its reliability, and I preferred the grip safety of thew "glock" safe action. This was perfect for us.
And no it was during reassembly the rod that is inside the recoil spring was protruding was about a 1/4 of an inch, so I am assuming I just did not have it seated correctly, as it appears for now I have it corrected. Next time I will take some time to photo it if it happens again. I really like the gun, it is beautiful and comfortable. I will recommend it to my friends but I want to throw another 100+ rounds through it to be sure the Malfunction was a fluke.
Disregard my first post Druff, I assumed it was a Sub Compact... I have the 4" and like it alot. The 3.8 is sweet also, well balanced and very shootable. Good Luck with it!!
"You don't have a soul, you are a soul. You have a body." CS Lewis
S&W .41 Mag - Colt DS - Ruger Single Six - Ruger Security Six - Buckmark-Beretta 21A - S&W 351PD 22 Mag- Spfld XD 9mm -- Plenty Of Long Guns--- Dry Powder and RCBS.
The range that I shoot at bans targets with any drawings of human beings on them, or photos of people. Many years ago targets with the image of Ayatollah Khomeni on them were quite popular, causing the ban. But rough silhouette targets are OK where I shoot.
Are they the only range near you?


text:
By Joe Fleming, USA TODAY
Roger Federer and Serena Williams validated their No. 1 seeds and rankings to claim Australian Open singles titles during the weekend in Melbourne.
For Federer, it was Australian Open title No. 4, and sweet 16 — to extend his record — in overall Grand Slams. Sweet because a year earlier Federer was in tears after a tough five-set loss to Rafael Nadal. Though this final, except for the tiebreaker, lacked the drama of a year ago, on Sunday it was Andy Murray whose voice was cracking after Federer's 6-3, 6-4, 7-6 (13-11) victory.
Federer saved five set points and wasted two match points in the tiebreaker with some uncharacteristic shot selection before clinching it when Murray netted a backhand after 2 hours, 41 minutes.
"I'm over the moon winning this again. I think I played some of my best tennis in my life these last two weeks," Federer said.
Indeed: Federer played in his 22nd Grand Slam final, his 18th in the last 19. And his streak of consecutive Grand Slam semifinals stands at 23. And he's the first father since Andre Agassi in 2003 to claim a Slam title.
Federer seemed relaxed throughout the tournament and was in control for most of the final. But his opponent must have been feeling some weight. Federer, in fact, joked after his semifinal win against Jo-Wilfried Tsonga about what Murray was trying to accomplish.
"I know Andy would like to win this first title in British tennis in, what is it, 150,000 years?" Federer said.
Not exactly 150,000, of course, but it might have seemed that way to Murray.
LOOK BACK: Australian Open in photos
AT THE TOP: Federer, S. Williams stay No. 1
Murray, who still leads his head-to-head with Federer 6-5, couldn't break the British drought in Grand Slams: nearly 74 years and counting (Fred Perry won Wimbledon and U.S. championships in 1936).
"I got great support back home," Murray told the crowd. "I'm sorry I couldn't do it for you tonight, but …" He paused to gather himself, then joked: "I can cry like Roger; it's just a shame I can't play like him."
Federer said Sunday he was just joking with his comments about the British wait.
"It's not easy … to win your first Grand Slam. … It's just a tough thing," Federer said. "(Murray's) game is so good, I'm convinced he'll win one."
On Saturday, Williams raised her total of Grand Slam singles titles to 12 — equaling Billie Jean King— and her Australian Open total to five (2003, '05, '07, '09-10). And it helps put the uproar from last year's U.S. Open deeper in the rearview mirror.
"I've totally moved on," said Williams, who was fined $92,000 in the aftermath of her profanity-laced tirade at a line judge during a semifinal loss to Kim Clijsters in New York last September. "One moment doesn't make one person's career. It's all about the moments you put together."
Other highlights from the season's first Grand Slam:
•Justine Henin is back. Though she came up a few games short in her 6-4, 3-6, 6-2 loss to Williams in the singles final, Henin, 27, delivered some thrills — including a second-round victory against Elena Dementieva — and showed she will be a contender at every tournament all year. She will reappear in the rankings after her next event (three tournaments are required). Even so, the French Open ought to think about seeding her in the top four when the tour gets to Paris for major No. 2.
•Kim Clijsters looked like she was ready to be a factor — until she took the worst beating of her career, a 6-1, 6-0, third-round thrashing at the hands of Nadia Petrova. Hopefully just a hiccup for the reigning U.S. Open champ — who beat Henin in her season opener in Brisbane — should be back in the mix the next time out, however.
•Though not in the vicinity of Britian's situation, the major drought for American men extends to 25 Slams. Andy Roddick's 2003 U.S. Open title is the USA's last. Roddick can still be a threat at Wimbledon and the U.S. Open, and John Isner looked good until he lost to Murray in the fourth round, but that drought no doubt looks likely to continue.
•Americans did fare well in the doubles. Serena Williams teamed with sister Venus to win the women's doubles — their fourth Australian Open crown and their 11th overall in Grand Slams — and Bob and Mike Bryan claimed their fourth title in Melbourne and their eighth Grand Slam title overall.
•The Chinese women made history with Li Na and Zheng Jie reaching the semifinals — the first time China has ever had two players advance to that level in a Slam.
•The Russian women bucked recent history, delivering no semifinalists for the second Slam in a row but for only the third time in the last 24 Slams ('10 Australian Open, '09 U.S. Open, '07 Wimbledon).
Nadal's knees
A year ago, Rafael Nadal had just reduced Roger Federer to tears in the Australian Open final. It was his sixth Grand Slam title, and his third victory in a row against Federer in a major final. By spring, however, Nadal's health — and tendinitis in his knees — was the main story line.
His knees are once again center stage.
Nadal will miss up to four weeks of competition to recover from a right knee injury that forced him to quit last week in the third set of his Australian Open quarterfinal against Andy Murray. After an MRI exam in Spain, doctors' advice was to rest completely for two weeks, then have two weeks of medical treatment before getting back on the court for real.
Nadal was adamant that this is not related to the tendinitis that sidelined for chunks of the latter half of 2009.
"As I mentioned in Melbourne after my match and at the airport as I landed in Spain, I know this is not the same injury I suffered last year,'" Nadal said in a statement. "I feel good, and I am only thinking now of recovering well. My main goal right now is to get ready again and fit to play the upcoming events once I am able to compete."
MRI and ultrasound tests showed a small tear at the back part of Nadal's right knee, which can be treated with physiotherapy and anti-inflammatory treatment, the doctor, Angel Ruiz-Cotorro, said in the statement.
Nadal will miss the ATP tournament starting Feb. 8 at Rotterdam, where he lost the final to Murray last year — and, incidentally, injured his right knee. Nadal should be ready to return in March for the big U.S. hardcourt duo, starting March 11 in Indian Wells, Calif., where he is the defending champ, and then moving to Key Biscayne, Fla.
In the short term, Nadal slides to No. 4 in the latest ATP rankings.
Nadal, who replaced Roger Federer in No. 1 spot for 46 weeks from August 2008 until July last year, said losing a few places in the rankings was not a concern for him. "It is not important for me the ranking issue and losing a few spots, that's normal when you are not able to compete," he said.
In the long term, however, it's hard to ignore the injuries, and hard not to ask what they could mean for his career.
His last title came in early May 2009, in Rome, on clay. Since then he has not been the force that tennis fans have come to expect.
Nadal, still only 23, plays a lot of matches, and his style of play is relentless — long points, wearing down opponents, defensive more than offensive — so he is on court a long time and his knees take a pounding.
"Everybody told (me) this in the past: 'This guy only can play two years like this,' " Nadal said last summer. "And then, it's five now. Five years I am there (in the top ranks). I am there. Still there, no?"
Still there, yes, but only part of the time … and he's not always the same guy who swept past Federer at Wimbledon in 2008 and in Melbourne in 2009.
Tennis shorts
•Fed Cup first-round matches begin this weekend, and just as is usually the case with Davis Cup, some big names will be missing. That starts with Venus and Serena Williams of the USA — part owners of the Miami Dolphins— who will be in Miami for Super Bowl festivities. The USA is not alone, however, in fielding a team without its top-ranked stars. The U.S. opponent, France, won't have No. 11 Marion Bartoli, No. 24 Virginie Razzano and No. 21 Aravane Rezai. Russia will be without No. 2 Dinara Safina, No. 4 Svetlana Kuznetsova, No. 7 Elena Dementieva, No. 14 Vera Zvonareva, No. 19 Nadia Petrova or former No. 1 Maria Sharapova (No. 16). Russia's opponent, Serbia, will have its top two, No. 8 Jelena Jankovic and No. 23 Ana Ivanovic. U.S. captain Mary Joe Fernandez's team, to meet the French on red clay in Lievin, France, will be: Melanie Oudin, Shenay Perry, Bethanie Mattek-Sands and top-ranked doubles player Liezel Huber. It will be good experience for Oudin, ranked No. 53, who has struggled since her surprising run last fall in the U.S. Open.
•China enjoyed unprecedented Grand Slam success at the Australian Open: Two players, Li Na and Zheng Jie, reached the semifinals — the first time China had ever had two semifinalists in a Grand Slam before. Li lost in a tough two-setter two eventual champion Serena Williams, and Zheng lost her semifinal to Justine Henin. Regardless, as the China Daily put it, "Victory in defeat at Australian Open." China's "Golden Flowers" — as the semifinalists were dubbed — brought a lot of excitement back home: Their matches were shown live, and they were replayed. It also was a pretty good bonus for the Sony Ericsson WTA Tour, which recently launched a Chinese-language website. WTA Tour CEO Stacey Allaster calls China "the magical area" for expansion. "We'd like to see more professional tennis in China," she said. … Now the Chinese men need to get with the program.
•Venus Williams served for the match against Li Na in the quarterfinals, but she couldn't close it out. Afterward, some of the questions in the post-match news conference were directed at Williams' lack of success recently in Grand Slam events besides Wimbledon. Williams, who will turn 30 in June, bristled. "Well … like I said so many times before, if I would have … gotten involved in what people said I would have never left the ghetto. So here I am playing pro tennis, playing well. The sky's the limit in this sport. I'm looking for that."
•Speaking of Venus, who knows a lot more about fashion than most, seeing as she is a designer herself and has a associate's degree in fashion: Her choice of the brown (skin-color?) one-piece under her tennis dress created quite a stir in Melbourne … and in the blogoshpere. The consternation forced Williams to respond, first on Twitter— "I am wearing undershorts the same color as my skin, so it gives the slits in my dress the full effect!" — and then in a postmatch news conference — "This is completely my design. When I design, I just try to stay true to me and just try to express who I am in the designs."
•The whereabouts rule — part of the anti-doping program — has caused quite a bit of controversy to open the 2010 season. WTA Tour CEO Stacey Allaster, for one, is not a fan. "There are rules in place and professional athletes have to follow the rules. Do the rules need to be changed? Yes, we are advocating for changes as it relates to (the) whereabouts program," Allaster said. U.S. Open semifinalist Yanina Wickmayer's case is the one that has caused the controversy: Wickmayer was banned in November for failing three times to report her whereabouts for drug testing. She never failed a doping test, and she claimed she was not properly informed of the online reporting requirements for drug-testing that led to her ban. The ban was overturned, and she won her season-opening event in Auckland, New Zealand, and lost in the fourth round in Melbourne to Justine Henin. Colleagues, including Svetlana Kuznetsova, and tennis observers, including John McEnroe, expressed their confusion and dismay at the rule. WADA's "whereabouts" rule requires elite athletes to make themselves available — at times they can specify — for out-of-competition testing on any given day. They must give three months' notice of where they will be so they can be tested at random. "During competition, we know where they are, they're here. They don't know if they're going to win a match or not. They don't know when they're going to get their practice court. It's very difficult to keep that system updated," Allaster said. "What works for all sports doesn't work for our sport procedurally when they are in competition. And they are in competition 10 months of the year."
USA TODAY's look at the world of tennis appears weekly. Contributing: The Associated Press; ATP World Tour; Sony Ericsson WTA Tour
Guidelines: You share in the USA TODAY community, so please keep your comments smart and civil. Don't attack other readers personally, and keep your language decent. Use the "Report Abuse" button to make a difference. Read more.


text:
|Price incl. VAT
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|Extended warranty + 1 year £41.51 Extended warranty + 1 year
|Return products within two months £25.94 Possibility to return products within two months
Enjoy a superior viewing experience with professional WQHD monitor ASUS PB328Q. His most detailed images with perfectly accurate color is ideal for playing games and watching movies is also suitable for working with graphics. Excels exceptionally wide viewing angles (178 ° / 178 °) and anti-glare. As a result, you will see distortion-free images at full quality from anywhere in front of the monitor. From an aesthetic point of view is very attractive extremely thin bezel, which you will appreciate, for example, when using two screens simultaneously. ASUS PB328Q achieves resolution up to 2560 x 1440 pixels, equivalent to four times the standard 720p monitors. This also means that you will have 77% more space on your desktop than is common with traditional Full HD screens. This difference is essential, particularly when working with complex video processing, graphics or audio.
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Use the intuitive controls to easily adjust hue and saturation, or make independent adjustment of red, green, blue, cyan, magenta and yellow, and without affecting the other colors. For the fastest access to the eight most used functions, ASUS OSD PB328Q customize shortcuts OSD by two special buttons. Another nice feature is the support of technology Picture-in-Picture (PIP) and Picture-by-Picture (PBP). They allow you to watch video and listen to audio from two different sources simultaneously, or between them easily and quickly switch.
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Link to Manufacturer's Website: Enter link to the external review


text:
Last Hour to Doomsday
2,570pages onAdd New Page
this wiki
this wiki
enter brief synopsis here
Detailed summary
enter full summary here
Featured Characters
(Numbers indicate order of appearance.)
|G.I. Joe
Featured Vehicles & Equipment
|G.I. Joe
Memorable quotes
"Ohhh, how could you do that to a poor little floppy disk?"
"That's nothing! You should see what Cobra did to ME!"
- --Mainframe and Lady Jaye disagreeing over who suffered more on their last mission.
Other notes
Animation and/or technical glitches
- The Vortex cone countdown starts at 48 hours, shown as 48:00:00. It then goes to 48:59:59. This is wrong as it should tick down to 47:59:59. Moreover, Hawk gives orders to the Joe team a few seconds later, and the clock behind him reads 46:28:94!
- This is even stranger as a clock should never read 94 seconds!
- When Wet-Suit begins to work on the underwater auxiliary panel, his wetsuit changes from the normal aqua to the generic orange and black wetsuits seen in the first mini-series!
Continuity errors
- No errors known.
Miscellaneous trivia
- This particular episode seems to have been written and produced before the " Arise, Serpentor, Arise!" mini-series; in fact, it appears to be a leftover Season 1 Episode! The emphasis is on classic characters Flint, Lady Jaye, Destro, the Baroness, and Cobra Commander; the Joes are using Dragonfly helicopters instead of the newer Tomahawks; Cobra is using Rattlers instead of the newer Night Ravens; Firebats are colored silver instead of the red from Season 2; Blueshirts are the Cobra infantry troopers instead of Vipers; and Cobra Commander appears to still be in charge of Cobra.
- There is no mention whatsoever of Serpentor, and Destro and Baroness report to the Commander throughout the entire episode.
- However, after dispatching the Giant Killer Octopus, Dr. Mindbender appears, but is not named, and both Flint and Lady Jaye seem to recognize him, thus implying that the audience should already know who he is. He also mentions that their demise by the Giant Octopus would have been better than the treatment he has in store for them, to which they seem to agree, thus suggesting they are of aware of his position as "Cobra's Resident Mad Scientist".
- Cobra B.A.T.s are so well-built, they're impervious to most non-laser assaults; in fact they can be severed in half yet continue to crawl forward toward their primary mission.
- B.A.T.s also function underwater with little difficulty; they're weighed down sufficiently enough such that they don't just float away.
- Lady Jaye takes out a B.A.T. by jabbing a hairpin in the back of its neck? Really!?!
- The neck may be a weak point. The stiletto dagger and rondel dagger were designed to penetrate the weak points of a knight's plate armour.
Real-world references
- No references.
- Coming soon
I'm just not seeing the big picture!!!
This cartoon episode article is a stub and is missing information. You can help Joepedia by expanding it.


text:
Helix initiate
this wiki
|I wanted to ask you something. Which is… what's your name?
The title of this article is conjecture. Although canon, no official name for the subject of this article has been given.
- This article is about the Helix user. You may be looking for another Initiate, or the research analyst.
- "Good choice. Welcome to the Assassins, Initiate."
- ―Bishop to the Helix initiate, 2014.[src]
The Helix initiate is an individual who was occasionally contacted by the Assassin known as Bishop. They were tasked by her to relive the genetic memories of Arno Dorian in order to find the Sage François-Thomas Germain and, later, the twins Jacob and Evie Frye to locate the Shroud of Eden.
Exploring the French RevolutionEdit
In 2014, the Helix user was contacted by Bishop after they had completed a playthrough of the memories of a French Templar serving under the Templar Grand Master and a Sage, Jacques de Molay. She explained to them that they were being manipulated by Abstergo Industries to sift through memories, following which she asked them to experience an unsequenced set of Arno Dorian's memories. Once the Initiate had completed the first sequence, Bishop offered them a chance to join the Assassins.[1]
After the Initiate accepted, Bishop sent them a video file of Abstergo's Phoenix Project, explaining that the Templars were searching for Sages both in the present and the past so they could sequence a full Precursor genome. The Initiate was tasked with exploring Arno's memories, as he had reportedly encountered a Sage at some point during his life time. In this way, the Assassins hoped to find out where said Sage's remains had ended up and recover them before the Templars could.[1]
When the Initiate completed certain memory sequences, Abstergo began performing a server sweep, forcing the Initiate's avatar to flee through Helix rifts to avoid being detected, transporting them into other historical periods in Paris.[1]
The Initiate's research eventually revealed that Arno had buried François-Thomas Germain's remains in the Parisian catacombs. This left Bishop satisfied with the results, as the bones would be too degraded for Abstergo to collect genetic memory data from them. She then asked the Initiate to continue searching Arno's memories for any information that could aid the Assassins.[1] An additional sequence of Arno's memories was later explored by the Initiate, who discovered that Arno had found an Apple of Eden underneath Saint-Denis and sent it to Egypt.[2]
Exploring the Victorian EraEdit
In 2015, the Initiate was contacted again by Bishop, this time to help herself and fellow Assassins Shaun Hastings and Rebecca Crane locate a Piece of Eden in London. Through camera drones, the Initiate watched the pair of Assassins conduct their field work and download the memories of Jacob Frye and his twin sister Evie Frye. Later on, the Initiate discovered that the artifact the Templars were after was a Shroud of Eden.[3]
During their explorations of Victorian London, the Initiate was contacted by Juno and sent forward into time, following Lydia Frye as she fought German spies in a war-torn London. Through Lydia's memories, the Initiate found another Sage. Juno spoke of her past, her working to save the world with other members of the Isu and the death of her husband. Though the Assassins saw it as their duty to fight her, she told the Initiate that another Assassin had "sided" with her previously and hoped they would too.[3]
Thanks to the Initiate's work, Shaun, Rebecca and Master Assassin Galina Voronina were able to find the vault where the Shroud had been stored. The Initiate then watched as the group of Assassins engaged Isabelle Ardant and her escorts, Juhani Otso Berg and Violet da Costa; ultimately Violet managed to escape with the artifact during the struggle.[3]
Despite the loss of the Shroud, Bishop was confident they would recover it in time and thanked the Initiate for their efforts. She then sent them a final piece of footage from Abstergo's computers.[3]
- According to Melanie Lemay, Abstergo had trouble finding researchers who could extensively explore the genetic memories of individuals with a high count of Isu DNA.
- ↑ 1.0 1.1 1.2 1.3 Assassin's Creed: Unity
- ↑ Assassin's Creed: Unity - Dead Kings
- ↑ 3.0 3.1 3.2 3.3 Assassin's Creed: Syndicate


text:
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DK scream 2
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Popular property highlights
Comfort Inn At Newport Beach places you within 2 miles (3 km) of popular sights like International Tennis Hall of Fame and Museum and Touro Synagogue. This 55-room hotel has conveniences like free breakfast, an indoor pool, and free in-room WiFi. It's in central Middletown and also close to The Breakers and Beechwood Mansion.
Free buffet breakfast is included with your stay.
The 55 rooms are air-conditioned and have an array of amenities, including microwaves, coffee makers, and free local calls. Guests can expect free WiFi and TVs with cable channels and pay movies. Other amenities include hair dryers, safes, and ironing boards.
Guests of Comfort Inn At Newport Beach enjoy an indoor pool, free WiFi in public areas, and a meeting room. Free parking is available if you drive. The front desk is staffed 24/7 to help with dry cleaning or laundry, and answer any questions about the accommodations. This hotel also has free newspapers.
Property features
- Free buffet breakfast
- Free WiFi in rooms and public areas
- Free parking
- Indoor pool
HighlightsInformation missing or incorrect? Tell us!Opens in a new window
Comfort Inn At Newport Beach
Hotel Amenities
Hotel Amenities
Guests can enjoy a complimentary breakfast. Wireless Internet access is complimentary. This Middletown hotel also offers an indoor pool, complimentary newspapers in the lobby, and dry cleaning/laundry services. Complimentary self parking is available on site.
Comfort Inn At Newport Beach is a smoke-free property.
- Number of buildings/towers - 1
- One meeting room
- Smoke-free property
- Free newspapers in lobby
- 24-hour front desk
- Total number of rooms - 55
- Number of floors - 3
- Free breakfast
- Dry cleaning/laundry service
- Elevator/lift
- Free self parking
- Indoor pool
- Free WiFi
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Microwave
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
Comfort Inn At Newport Beach offers 55 air-conditioned accommodations with safes and coffee/tea makers. Televisions come with cable channels and pay movies.
Bathrooms include shower/tub combinations and hair dryers. This Middletown hotel provides complimentary wireless Internet access.
- Free cribs/infant beds
- Pay movies
- Air conditioning
- In-room climate control (air conditioning)
- Microwave
- Hair dryer
- Coffee/tea maker
- Free local calls
- In-room safe
- Iron/ironing board
- Cable TV service
- Shower/tub combination
- Television
- Free WiFi
Where to Eat
Guests are offered a complimentary buffet breakfast.
Nearby Things to Do
Recreational amenities at the hotel include an indoor pool.
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- In-room accessibility
Hotel Policies
Check-in time starts at 3 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children 18 years old and younger stay free when using existing bedding.
- Free cribs (infant beds)!
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
Hotel Name
- Comfort Inn Atlantic Beach
- Comfort Inn Atlantic Beach Hotel
- Comfort Inn Atlantic Beach Hotel Middletown
- Comfort Inn Atlantic Beach Middletown
- Comfort Inn Newport Beach Hotel Middletown
- Comfort Inn Newport Beach Hotel
- Comfort Inn Newport Beach Middletown
- Comfort Inn Newport Beach
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


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Skaliey – Shinpaka Story [AuDio]
Singer, Skaliey has dropped his much anticipated EP 'Shinpaka Story'.
'Dadubule' crooner surprised fans by dropping the EP Surprisingly.
'Shinpaka Story (EP Tracks)' has two tracks and no features 'Story' and 'Shinpaka' (All Tracks Produced by TP Flex).
Listen Up & feel the Vibe!
Click for Trending DownLoads this Week
Categories: Music


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You Are here > Home > North America > USA > Florida > Haines City > Listing 576
Located in Davenport
Bedrooms: 4
Sleeps Max: 13
Bathrooms: 3
Year Built: 2007
Storeys: 1
Internal Area in m2:
Plot Size in m2:
Car Parking: off-road
Is Car Hire Advised: Yes
Rental Rates - per weekLow Season: £ 800.00 - EUR 918.00 - USD 1,027.00
Mid Season: £ 0.00 - EUR 0.00 - USD 0.00
High Season: £ 0.00 - EUR 0.00 - USD 0.00
Notes to the prices
A 10% deposit + the security fee will secure your booking
The villa in Haines City, Florida is fully furnished to a high standard and is an excellent place for your Orlando vacation. There are 4 generous bedrooms, as well as a sleeper sofa in the living room. For extra entertainment, there is a games room with pool table, air-hockey and foosball.
This is an excellent opportunity to be one of the first to stay in this luxury villa.
Brand new, built in July 2007.
Villa Features:
*4 bedrooms - 2 master bedrooms with queen beds & 2 bedrooms each with 2 single beds
*Wireless Internet access
*Free local, national & international calls
*Cable TV in all bedrooms, living room & den
*DVD players in all bedrooms, living room & den
*32" LCD HD TV in living room
*Playstation 3 in living room
*Playstation 3 games & Blu-Ray movies
*Games room with:
-pool table
-electronic darts
-kid's multi-games table - pool, ping pong etc.
-board games
-table & chairs
*fully equipped kitchen:
-fridge freezer with ice-maker
-oven & hob
*Sleeper sofas in living room & den
*Travel cot
*Pool & spa
*Patio table & 4 chairs
*4 loungers
Comments from previous guests
"I enjoyed my stay, The owner welcomed our family when we arrived that was very nice . The home is very beautiful and had lots of things to keep my kids busy . It was like home away from home . Thanks Mark"
The Blocker Family, July 2008 USA
"Big rooms, well furnished and equipped, far better than expected for a rental property. Wish we had walk-in wardrobes at home! Highly recommended. Everything clean and well presented. The sat-nav loan was really helpful."
The Lomax Family, June/July 2008 UK
"We would highly recommend this amazing house to anyone visiting Orlando. It is equipped with everything you could possibly need(and more). Our favourite things at the house included the pool (of course), Playstation 3, walk in wardrobes and the biggest corner bath ever seen! If we get the chance to go back to Florida we will definitely use this house again.
Thank you Mark & Debbie x"
The Gilbert Family, June 2008 UK
"We had a fantastic time in florida which was made more welcoming by this lovely home. After long days at the parks it was great to come back relax in the hot tub whilst the children had pool competitions in the games room. Bliss!!
Thanks again"
The Whitaker Family, March 2008 UK
"Just a short note to thank you for letting us use your villa. The kids had a great time in the play den, pool and on the PS3. We also had a good time in the villa. It is lovely.
Once again many thanks."
The Culmer Family, March 2008 UK
"An excellent villa in a great location.It has everything you will ever need to make your stay superb.We had a fantastic time and if a cynical,bitter and twisted old bu**er like me enjoyed it then it must be good!"
The Dugmore Family, February 2008 UK
"It felt like home! Our family loved your villa. This was our first Christmas family vacation with all children and your villa was the perfect place to make memories for us all. Thank you so much for putting up the Christmas tree. It was also an oasis for my husband who has been serving overseas for the last six months. Our children ages 15-22 loved the game room, pool and each having their own room. The villa was cozy, yet spacious. We will definitely look forward to staying with you again and refer our family and friends."
The Filsoi Family Christmas 2007 USA
"Our stay was wonderful. The twins loved the pool/hot tub/and Disney room and teens found plenty to do in the game room. We would definitely rebook with you in the future = thanks for your personal service and a wonderful stay in Orlando. "
The McCall & Barndt Families Nov 2007 USA
"The villa was great, comfortable, clean and it was like home from home! (except i don't have a swimming pool in my garden!) and the location was also very good close to all the theme parks.
We had a really good time and will most definetly consider booking with yourselves again if we re-visit florida."
The Holden Family Oct 2007 UK
"We had great time and villa was excellent.
A luxury 5 star villa in a good location with easy access to Disney via H27&I4.
Games room ideal for kids and adults. South facing pool with 4 sunlougers.
Wall Mart, other shops,restraunts and South Dunes golf course minutes away.
An ideal base to explore Orlando which I would highly recommend."
The Oliver Family Sep/Oct 2007 UK
Property Benefits
General FeaturesAir Conditioning, Cable/Satelite TV, Carpeted Floors, Central Heating, CD Player, DVD Player, Furnished, Games Console, Hair Dryer, Internet, Jacuzzi, Pool Table,
Outside FacilitiesHot Tub, Loungers, Outside Dining, Pool, Shade, Table/Chairs,
Local Activities and SuitabilityClubhouse, Disney, Restaurants/Bars, Theme Park,
Kitchen and Dining FacilitiesCooker, Cutlery, Dishwasher, Dining Table, Freezer, Fridge, Gas Fuel, Grill, Microwave, Pots/Pans, Toaster, Washing Machine,
Bedroom and Bathroom Facilities4 Bedrooms, 4 Double Beds, 4 Single Beds, 1 Cots, Free Linen, 3 Bathrooms, 2 Ensuite, Free Towels,
Unsuitable For
More Information...
Contact the owner direct, to get a great deal on a vacation in Haines City.
Advertiser since: Aug 2007
Date Added: Sun 05 Aug 2007
Updated: Wed 11 Aug 2010
More Information...


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3 reviews | 5 out of 5
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The lip is dry in winter. But when i own this, it's not a problem. Good smell and shine . Before sleep I put this on my lip and happy to have a dream.!Recommond this to you! I love it.


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Industrial and commercial lighting at wholesale prices
The central design element of the traditional Northbrook Collection is inspired by a turned spindle in delicate contrast with the soft, clean curves of the glass, creating an impactful overall look.
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Isobel: Surprise PartyMature
'Did you want to come round mine tonight?' Elijah asked me after school. 'You can meet my mum.'
'Oh God,' I laughed. 'Is she gonna be nice to me?'
'Sure, she'll love you.'
'I don't see why not,' I grinned. 'Have you seen Chrissy today?'
'Yeah, I saw her briefly in the hallway talking to Rhea earlier. Rhea looked pretty upset but Chrissy wasn't having any of it.' He pursed his lips slightly. 'I hope this isn't gonna cause awkwardness.'
'It won't,' I squeezed his hand. 'We'll all be fine.'
The walk to Elijah's house was short and as I found myself wandering onto his road, I did a double take. This was the estate that I walked past every day before school, admiring the huge houses and the vast stretches of immaculately decorated gardens. I had always pretended I lived in one of these houses, that my family were incredibly rich and we all lived together happily.
Sad, right?
But now Elijah led the way through a set of heavy iron gates, up a patio driveway and straight through a heavy wooden door. I was instantly hit with the aroma of strawberries and cookie dough.
'Something smells good,' I noted.
'My mum likes to bake,' Elijah pulled a face, much to my amusement.
He guided me through a long hallway decorated with a cream carpet and beige coloured walls. Photographs hung in a neat line, various school pictures, some family shots and an old black and white one of a stern looking woman with steely eyes and a thin line for a mouth.
A woman who looked a lot like Elijah was wearing an apron and had a mixing bowl tucked in one hand and a wooden spoon held in the other. Her face was dusted with powder and the worktop was littered with empty packets and plastic wrapping. She turned to face us and broke out into a friendly smile. She had very dark hair that was now pulled away from her face in a loose ponytail and laughter lines etched around warm blue eyes.
'Hello dear,' she spoke. 'You must be Isobel.'
'Hello,' I grinned, all feelings of apprehension and dread soon melting away.
'You've made my son quite smitten, he's told me a lot about you.'
'Mum, please,' Elijah muttered beside me. I giggled. 'Well anyway, we'll be upstairs.'
'Okay dear. It was nice meeting you Isobel.'
After a little wave, I followed Elijah back down the hallway and up the stairs.
'She seems lovely,' I said fondly.
'Yeah,' he smiled. 'She is great. She's always been there for me, especially after...well, after my father left us.'
'Oh,' I frowned. 'I'm sorry to hear that. Do you still...speak to him?'
'Nah,' he shook his head quickly. 'Waste of space anyway.'
I decided not to pry any further. I could tell he didn't want to speak about it and it saddened me greatly to know that someone would just pack up their things and leave Elijah without so much a glance behind them.
Elijah pushed open a door to reveal his room. It was how I had imagined it. The carpets were a shade darker and the walls were painted a light blue. A big double bed sat in the corner of the room, directly beneath a large window that overlooked the front garden. A large bookcase took up the majority of one of the walls, stuffed with books I had never even heard of before.
'You have a really nice room,' I began, but was shortly interrupted by my phone ringing. 'Sorry, I'll just be a second.'
'That's okay,' Elijah smiled easily.
'Hey Isobel.' It was Tom. 'Listen, it's Rhea's birthday today and I feel kinda bad. I think we should all do something, like a surprise party for her.'
'Oh,' I said, completely surprised. 'I didn't know it was her birthday. Um.. I'm with Elijah at the minute, I'll see what he thinks about it.'
'Hey Elijah,' I covered the mouthpiece of my phone. 'Tom's saying it's Rhea's birthday today and he wants to do a surprise party for her. I don't think anyone realized it was today and he's feeling pretty bad. Is that alright?'
'Of course it's fine! Did he want us to meet him somewhere or...'
'Hang on. Hey Tom, did you want us to meet you?'
'Yeah, Chrissy said she'll swing by Elijah's house to pick you guys up and then we'll head over to Rhea's. We've picked up a few things, a birthday cake, a few bits of food and some presents. I was thinking we could have a mini party type thing.'
'That sounds great. Do you know where Elijah lives?'
'Nope. You'd need to give us the address.'
* * * *
Fifteen minutes later and we were all stood on Rhea's doorstep. We had a bag full of food, including the birthday cake, some shots and bottles of alcohol - Chrissy's idea - and a few presents that Tom and Chrissy had picked up.
'Do you think she'll want this?' I whispered.
'Why are you whispering?' Chrissy arched an eyebrow. 'She'll love this. Well, she'd better do anyway.'
It was obvious Chrissy was still bitter about the whole situation with Tom and Rhea, but she had every right to be. I couldn't imagine how I'd feel if Elijah kissed someone else..
'Guys, we should hide round the corner, so Rhea thinks it's just Isobel,' Tom suddenly piped up. 'Then we can surprise her.'
'That's a good idea,' I chipped in. 'Go away.'
I watched them all head round the corner before tapping on the door. It swung open seconds later to show Rhea looking miserable. She tried to smile, for my benefit, but I could see beneath it.
'Isobel?' she was surprised.
'Hey Rhea. Tom said it's your birthday?'
'Yeah, but..what are you doing here?'
'Oh come on, you can't expect us to not do anything for your birthday.'
Right on cue, Tom, Elijah and Chrissy rounded the corner with a chorus of Happy Birthday. Cheesiest thing I had ever seen in my life, but it certainly seemed to please Rhea.
'Wow,' she gasped, laughing slightly. 'Chrissy? You turned up. Does that mean that we're okay?'
'We're good,' she nodded, a smile playing on her lips. 'We allowed in then or are we just gonna stand here all night?'
'Yeah, come in,' Rhea stepped to the side and we all filed in.
'We brought some DVDs, some alcohol and a birthday cake. We didn't know what you'd like so um, take your pick I guess,' Elijah chuckled.


text: GST interaction Entities can only claim ITCs on deductible entertainment expenditure and entertainment expenditure that is subject to FBT. If, throughout the year, entities expect to use one method of calculating FBT on tax-exempt body entertainment and at year end the entities use another calculation method, they will be required to process an adjustment to the BAS. For example, if an entity expects to use the 50/50 method for valuing tax-exempt body food and drink entertainment fringe benefits, throughout the year it will claim 50% of the ITCs attributable to tax-exempt body food and drink entertainment expenditure. If at year end it decides to use the actual method because it determines that only 45% of expenditure relates to employees, it will have to process an adjustment to the BAS equal to the ITCs on 5% of expenditure. The adjustment should be made in the next BAS following lodgment of the FBT return in accordance with Subdivision 69-B of the A New Tax System (Goods and Services Tax) Act 1999. Last modified: 17 Jul 2012QC 21998


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19 Creative Portfolio Websites to Inspire You
- Details
- Created on Tuesday, 11 October 2016 10:47
- Last Updated on Saturday, 04 March 2017 17:17
- Written by Terrence
- Hits: 3543
Creating portfolio website is one of the most challenging task for web designers. Beautiful portfolio not only displays the outstanding talents up for hire, it is also makes design works sparkle and grabs visitors attention immediately. Did you check our roundup with 10 Beautiful & Clean Web Designs Inspiration 2015 and also our previous list with 12 Creative Photography Websites to Impress You?
10 Beautiful & Clean Web Designs Inspiration 2015
- Details
- Created on Monday, 11 May 2015 03:03
- Last Updated on Monday, 07 November 2016 06:57
- Written by Terrence
- Hits: 3750
Web design grows and so many awesome things are being published daily and web design has changed dramatically. Modern design trends have rapidly improved. Flat color scheme, web typography has got much better. Below I have listed 10 clean sites will impress you.
12 Creative Photography Websites to Impress You
- Details
- Created on Tuesday, 28 April 2015 09:58
- Last Updated on Tuesday, 02 May 2017 06:24
- Written by Terrence
- Hits: 3139
If you want to become a successful photographer you should have an online beautiful online portfolio. Most clients believe only what they see. You portfolio site is a visual proof for them to witness your personality, skills and creativity. I have listed most beautiful and Photography websites that you could find, analyzing the design trends.
19 Creative and Fresh Green Websites for Your Inspiration
- Details
- Created on Tuesday, 07 January 2014 15:42
- Last Updated on Tuesday, 07 January 2014 16:14
- Written by Terrence
- Hits: 2408
Green background websites are giving yourself relax and refreshing. That's why it is became one of the preferred colors of web designers today. In this post I will showcase collection of fantastic website designs featuring the color Green using many creative ways! Green often conveys nature/environment which can be handy for a business of that field. If you're designing a site with a lot of green, take a look at the sites shown here and you'll get some ideas of other colors that could complete your color scheme.
19 Beautiful Flat UI Web Designs for Your Inspiration
- Details
- Created on Wednesday, 18 December 2013 04:46
- Last Updated on Wednesday, 18 December 2013 14:22
- Written by Terrence
- Hits: 2226
Flat web design is a growing trend in 2013 and that shows no sign of stopping. With the Apple iOS7 and windows 8, web designers do not want to miss out on the move towards flat design. Flat UI will make responsiveness easier. With the growing trend in responsive web design, Flat UI make the website more fun. In this post I have put together collection of the best of what has been produced recently in the area of flat web design. I hope you enjoy the collection and find inspiration too.


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Financial Translation
Rosetta Translation specialises in providing financial translations for a wide range of well-known financial institutions and corporate. Financial translation is a very specialised area, and we are one of the leading experts in the field.
Financial Translations of the Highest Quality
Having originated as a financial translation company, we have wide-ranging experience across the whole spectrum of the financial services industry, from banking, i-banking and insurance to asset management.
Our blend of experienced, skilled language professionals, industry experts, and project managers makes Rosetta ideal for even your most complex and specialist financial translation needs.
For a free instant quote, please contact us at any of our local offices in London, Shanghai, New York, Paris or Luxembourg.
Highly Acccredited Financial Translators
Rosetta has been ISO 9001 qualified for over a decade now, providing its customers with the piece of mind that we have very robust processes. We have also achieved the DIN EN 15038 norm, the only certification that specifically focuses on quality in translation services.
Recent Financial Services Translation Clients
Our greatest argument for the consistent quality of our financial translation services is perhaps the number of high profile clients across the whole spectrum of financial services, for which we provide regular translation. Thus, we are a preferred supplier for American Express worldwide, for the European Investment Bank in Luxembourg as well as for ACCA (Association of Chartered Certified Accountants), the global body for professional accountants. We obviously also complete financial translations for a large number of non-financial corporates.
Selected Companies that Rosetta Provides Financial Translations for
American Express
Barclays Bank
European Investment Bank
Jardine Lloyd Thomson Group
JP Morgan
Legal & General
Lloyd's of London
Oliver Wyman
National Australia Bank
National Bank of Greece
National Bank of Kuwait
Royal & Sun Alliance
Royal Bank of Scotland
Translators Experienced in the Finance Industry
Linguistic and technical accuracy is arguably more important in financial services than in any other business.
We achieve a consistently high standard in our financial translations by using only the most highly qualified translators and proofreaders who will either have an extensive background in the financial services industry or will have undergone specific financial translation training.
Different specialisations within finance obviously have their own linguistic usage. We carefully assemble the most appropiate team of translators, proofreaders and editors for each document and client. This approach is particularly important in multi-disciplinary assignments, such as the translation of derivatives contracts, marketing material for investment funds or a feasibility study.
Client-tailored Project Management
In order to facilitate clear and direct communications, each client is assigned a single project manager. The latter works closely with our financial translators and proofreaders to ensure that any arising linguistic issues are promptly resolved and that the timeline of each translation is respected.
Glossaries play an integral part of our quality assurance cycle and are built and maintained centrally. For regular clients, these glossaries reflect any specific client-internal terminology or usage, so that each translation is stylistically identical to the client's existing corporate communications.
This translation process ensures high quality and consistency throughout the translation of individual documents, which may have to be split between multiple translators, and across multiple documents for the same client.


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Subject 14: unleashing powerMature
Subject 14 (Kishto)
I make sure fifteen was on his feet against the wall before darting into the cafeteria to join the fight. Inside the cafeteria, havoc reigned. The few guards were desperately trying to fire their M4, they wanted to aim at the rebelling subjects but it was difficult because the scientists were scrambling in fear. Thus making it hard to have a clear aim at the subjects to sodomize them. The only things the guards could do was physical fight, that was, whack the weapon on the various subjects head. The rest of the subjects were either running and hiding in confusion or joining the fight as well, many sought the scientists whom they had seen after the operation (they had the idea that they had done something to them and seek revenge). The scientists ran for cover, they had no weapons with them, they pleaded mercy before falling into the mob of choleric subjects.
I shun out the chaos and confusion out of my mind and set it to the most important goal: escape. Just in front of me, a guard was batting its M4 on a defenseless subject, I thrust my hands forward causing the air molecules surrounding the M4 move faster, creating friction between the molecules and finally the friction caused a spark. It was like making fire out of air, the spark ignited a flame that enveloped the guard. I helped the subject stand up.I felt light-headed after my first use of molecular manipulation, breath seem to falter, my heart was beating hard in my chest.
"Fourteen!" subject 42 had approach me, "I took care of the entrances, they are well shut. We got some minutes before reinforcement comes along."
I nodded, "Let's go to the upper levels, we need to get that window open." I ran to the upper levels of the hanging floors, some scientists had committed suicide by jumping off the hanging floors into the main floor, some chose suicide rather than being torture on behalf of the madden subjects. The guards had made it imperial to kill the subjects, gunshots erupted from their automatic weapons and it was aimed directly at the subjects. The firing would not cease, they would kill regardless of who was in the way. I darted bullet after bullet, we were so close to liberty.
I jumped from hanging floor to hanging floor, all of them were shaking, the suspension cables were weakening and they were swinging from the roof. Screams were continuous and increasing in volume. When I reach the upper level, only the window separated us from freedom. That was when the alarm blasted to life. I placed my hand upon the windowpane, it sure was a thick window. I knocked on it, it was bulletproof too, to lock whatever it was beyond these walls to keep it inside. The upper levels highly contrasted what was going on below me. The upper level was quite calm, with little scientists and subjects. The subjects who had made it so far were banging, scratching, hitting, striking the windowpane, a futile effort because the window seem unbreakable.
I heard a shot from my left, pain shot through my arm, I heard myself screaming in agony. I fell on my knees, blood was trickling from the wound inflicted by a fire weapon on my left arm. I turn to see the shooter, it was a guard, he was laying on the ground with shaky hand grasping the gun. He too was bleeding from his leg, apparently he had been in a mortal fight with another subject and was just barely alive. My mind was slowly taking in my surroundings, my thoughts slipping from my mind, beyond reasoning.
I was lost in this power, lost in this spell. I closed my eyes and the moment I opened them they weren't green anymore, but shining white. I breath with difficulty, preventing my life breath from leaving my body. My teeth gritted from the anger, the guard was frightened to see who I had become, his fire weapon fell to the floor. I was enraged, blood drops from my wound were being soaked by the clothes every subject had been provided. Without thinking, I outstretch my right hand, with a swift and simple movement of my wrist I lifted the guard and send him flying toward the abyss of confusion down below. He guard fell, his screams were drowned by the turmoil in which he had fallen.
I was not under control anymore, my heart beat faster and it ached every second, but I did not pay any attention to it. My powers, and not my mind, were in control of my whole body, they were feeding from my anger. Consciousness was slipping away, I was at the mercy of the wrath of my powers.