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|1,120 sq. ft.
|Property type
|Minimum Stay
|7 - 14 nights
Siesta Dunes is one of the most desired complexes on Crescent Beach. Our condo is on the third floor of Building 1 and has been updated with cherry wood cabinets, granite counter tops and stainless steel appliances. Sleeping accommodations feature a king bed in the master bedroom and a full plus a twin in the guest bedroom. There is also a queen sleeper sofa in the living room.
Our kitchen is fully outfitted if you feel like cooking, or you can go out to one of the many nearby restaurants.
Crescent Beach is considered one of the top beaches in the world (rated America's best beach in 2011) due to its soft white sand that never gets hot. If you don't care for the sand, you can enjoy the sun on the sun deck overlooking the beach or at the pool. At the end of the day you can catch some of the most magnificent sunsets from the deck or the beach.
Keywords: Condominium
Owner Gregg David
Gregg David purchased this condo in 1999
My family had vacationed on Siesta Key for many years prior to my brother and I purchasing our condo. We bought at Siesta Dunes because it is one of the finest complexes on Crescent Beach.
From our building (building 1) it is just a short walk to the tennis court, the pool area, the sun deck or the gorgeous white powder sand and gulf.
This is my first time at the condo and Siesta Key and I can't say enough good things about it. Wish I could have stayed longer!!! The condo was clean, comfortable and everything we needed to make our stay absolutely wonderful. The salt water pool was refreshing after a day on the private beach. A true home away from home. The sunsets were spectacular at the end of every day. The condo was very spacious. It had all linens, beach towels, kitchen utensils, great BBQ outside on the grounds. . Free WiFi was was great. The golf courses were close and some even gave you breakfast and lunch with your green fees.The area is close to all restaurants, and even Costco.The grounds are well kept and well lit at night. It is very quiet and a great place to relax. I highly recommend this condo for your beach vacation. I am looking forward to staying here again.
Thanks Greg!!
This is a really nice condo in Siesta Dunes. The description is accurate and the condo is well-maintained, however the condo is nicer than the photos reflect. The kitchen and master batch are excellent. Although the unit is located by the elevator, it is very quiet. The coin-operated laundry room is right around the corner. We also thought the shopping cart was a great idea for assisting with moving in/out.
We have a 6 and 3 year old and this condo was perfect for our agenda...beach, pool and repeat. We enjoyed Walt's Fish Market & Restaurant along with using the complex's gas grills.
Would definitely recommend this unit to family and friends.
This is the second time I've stayed in this condo and I would definitely stay here again! I love the location with private access to the most beautiful beach on Siesta Key! The condo is very clean with a nicely remodeled fully stocked kitchen, has plenty of room for a family, several beach towels and even some beach toys. Siesta Dunes is very well maintained with a nice warm saltwater pool, clubhouse and beach chairs. The location is very close to a small grocery store and a few restaurants (City Pizza is very good!) and just a couple miles from the village and Big Olaf's ice cream (which is a must stop). We walked down the beach to get ice cream which was good exercise and helped justify eating the ice cream in their homemade waffle cones. We drove the first time we visited (they have a nice carport), but just took a cab to/from airport and didn't rent a car this time. We could easily get around by either walking or calling the Surfside Free Ride (tips only) service. We liked them much better than Siesta Key Free Ride. The public beach is crazy crowded which made us appreciate the beach even more on this property! I'm always sad to leave this wonderful place to come home, but will definitely return!
We had a wonderful time at this condo in Siesta Dunes. Very clean and well appointed kitchen amenities. Had everything we needed for the week stay. The only comment would be; it would have been nice to know that it included beach towels. We would not have brought ours and used extra space in the suitcases if we had known. It turned out to be a bonus that future clients might find useful. All in all, we would certainly recommend this property.
The condo was beautiful! Loved the new kitchen. The master bedroom bed was the most comfortable. Our highschool seniors had the most memorable spring break, thanks to Siesta Key, and this awesome condo!
This year my wife and I decided to take our Christmas holiday on the road and we could not have had a better time! This property was outstanding and the condo unit itself was perfect! I would like to thank the owner personally for all his help during the booking process. In one breath I want to recommend this place to everyone but selfishly I want to keep this jewel my own little secret...... All kidding aside I recommend this place highly. The area offers so many places to eat its almost impossible to pick one out however rest assure there is something for every taste from fast food to high end steakhouse and more! Last but not least the beach!!!!!!! Only one word can accurately describe it "breathtaking"
We will be back again soon!!!
|Rate Period
|Weekend Night
Mid-Summer 2017
Jul 1 2017 - Aug 5 2017
7 night minimum stay
Dec 23 2017 - Dec 30 2017
7 night minimum stay
Jan 13 2018 - Apr 28 2018
14 night minimum stay
My Standard Rate
7 night minimum stay
|Refundable damage deposit
|Tax Rate
Reservations are confirmed upon receipt of security deposit.
Jan. 16 - Apr. 30
- $800 security deposit ($400 applied to prepaid rent), $400 will be refunded 30 days after departure
May 1 - Jan. 15
- $400 security deposit, refunded 30 days after departure
A 60-day cancellation prior to the date of arrival is required for a refund of deposit
Upon arrival, the remaining balance of the rent and tax is due. Payment in full is required prior to arrival for all Guests arriving after business hours and/or on Sundays. All rates are subject to applicable Florida Sales Tax. Payment can be made by cash, money order, personal check, Visa, MasterCard, Discover, or traveler check in U.S. funds only.


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Much has been written about the myriad industrial applications for silver, and even more since announcements from China and Japan of plans to accommodate increased reliance on solar power by 2015 in satisfying their growing energy needs.
Last month, according to Jeff Clark of Casey Research:
China raised its target for solar generating capacity to more than 35 gigawatts (G W) by 2015, a stunning increase of 67% above its previous target.
Take note: I am not a financial planner, adviser, accountant, economist or alchemist. I started investing late and I'm not a millionaire. I am a logical thinker looking for answers. I won't spin a bunch of numbers, won't argue shrinking global mine output, and I will not talk Fed money printing, however this article does intend to make a case for silver surpassing gold in future demand.
I know, you might think I wear a tin foil hat, but add this to your thought process. Silver remains the most reflective, heat resistant and electrically conductive material on earth. Its beauty and resilience makes it perfect for jewelry, and the shiny metal enjoys rising popularity among retail investors because of its close relation to money and value as a hard asset.
Silver has something special going for it
The Casey Research chart below does not include future silver demand associated with the new solar panel initiative. It only illustrates industrial demand in year 2012.
(Pie Chart Courtesy Casey Research)
Nothing beats silver for use in everything electronic from smartphones to computers to television screens to, well, generating electrical power by converting solar radiation into direct-current electricity through the use of semiconductors in photovoltaic technology used in the manufacture of solar panels. And each solar panel contains near two-thirds of an ounce (20 grams) of silver.
The Jeff Clark piece is very informative and a suggested read. He continues:
It's estimated that over 50 million ounces of silver will be devoted to just the solar industry this year. China's proposed boost from 7 to 35 GW in capacity would translate into a global increase of 27%, from 102.2 GW last year to 130.2 GW in 2015. Meanwhile, Japan is expected to overtake Germany as the world's largest solar energy user. An estimated 5.3 GW of generation capacity-the equivalent of five nuclear reactors-will be added this year, according to a report from HIS Inc., a US-based research firm.
What most concerns me is this: in most all consumer applications, i.e. smartphones, computers, etc., the silver used is used. As in, never-to-be-recovered. Though scientists say there is 16 times more silver occurring in the earth's crust than gold, this will inevitably come to pass at our current rate of consumption.
Also, considering how much is made about the use of silver by the industrial complex, one major user of silver is rarely ever discussed - the military industrial complex. The military uses silver in everything from communications devices to medical applications, to weapons launch systems to weapons themselves. It is widely believed, though not confirmed, each Tomahawk and Cruise missile contains over 500 ounces of silver. Which suggests every time one of these missiles is deployed another unrecoverable pile of silver is used up. Gone.
Not to make this a geopolitical discussion, but how many missiles were lobbed into Libya in 2011? I've read different accounts of 168 up to 200 depending on what page you turn to. But if you do the math here I've furthered my point.
If war remains a booming business we can expect more silver to be wiped off the face of the earth while tons of mined gold remains safely inside someone's vault, or safely in transit between one vault, to another.
It is my belief silver will outperform gold over the long run. How do we benefit?
There are several "good choice" silver mining investments including those I've detailed before such as Endeavour Silver (NYSE:EXK), First Majestic Silver (NYSE:AG), McEwen Mining (NYSE:MUX), Paramount Gold and Silver (NYSEMKT:PZG), as well as Silver Wheaton (SLW) and others, but let's not get ahead of ourselves.
Even though shares of the miners, explorer and streamer mentioned here are selling at attractive prices, nothing will beat physical hold-in-your-hand silver when the world supply is near depleted or runaway inflation shows up at the party.
And when silver does turn scarce or the market does hit another volatility speed-bump as was the case during this mid April past, bullion dealers will raise their premiums. Not only that but, in many cases forced to delay shipments, put items on back-order or show in-stock items as "out of stock."
In the case of spot prices surging due to increased demand and the eventuality of scarcity of silver, dealers will in fact be out of stock. But even now with higher premiums due to lower spot prices (inherent volatility) vendors are put in a position of having to sell inventory for less than they paid for it. And if it is scarce, not sell it at all. In either case OUT OF STOCK will become in style.
I can speak to this. It happened to me. Did this happen to you?
Smelling smoke after market close Friday, April 12, 2013, I made an online purchase that I had been waiting on and price measuring; a 20-ounce mint tube of one-ounce .999 pure silver, Austrian Philharmonic bullion coins I was to give as a wedding gift.
Sure I could have locked in a lower price had I waited even longer as spots continued downward in the days following, but if I had waited and made my purchase on April 15, or later, my wedding gift would not have arrived until after the wedding, two months later. As it turned out it took almost four weeks for delivery (just in time) when normally it would have taken 10 days or less. Availability became an increasing concern.
This is what will happen again when silver scarcity or real inflation hits the mainstream media's breaking news desk and people who thought before they couldn't afford gold will be shocked at its new price as everyone pours into silver only to find it out of stock.
Silver's surge will be spectacular, realizing much higher percentage gains than gold.
In conclusion, if you've kept up with me over time you've seen me write "silver could be good as gold one day." And this I do believe. But maybe I should just keep quiet. After all, I don't need more competition securing the last grams of silver on earth. Go ahead, I can hear you now sharpening your pencils readying even sharper remarks for me in the comments section below. But, that's, OK I'm inviting you aren't I?
Good advice here is simply to buy your silver now.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

subset: commoncrawl


text:
Which digital camera should you buy?
I recommend CANON A650 or CANON SX100, both of them are great .I recommend canon a650.I recommend CANON SX100It depends how much money do you have? For example for around 200 $ i recommend canon a5...
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Which Canon digital camera body should you buy in order to use old lenses from a Digital Rebel XTI?
Any Canon camera with the EF-S lens system will work. That includes but isn't limited to all of the rebels (XT, XtI, XS, XSI, and the new T1I). The only cameras that WON'T work with your Rebel XTI...
Read More »
Which Digital SLR Camera Should I Buy?
There are a number of good brands so don't be sold on the idea one brand is better than another. I would keep your costs down. I would get a DSLR with a short zoom (like a 18-55mm) to start. No r...
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Which digital camera should I get?
Hi. To take the kind of pictures you want to ( concerts) and to do a good job .. you may have to spend a little more than you mentioned .... but not much. I use my Canon EOS Rebel digital slr camer...
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Which digital camera should I buy?
go with sony. it has all the features, better durability, better picture quality and overall best performance than others.Sony-DSC-S730Rs 7,450/-7.2 mega pixel digital camera comes with a CCD senso...
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College of Central Florida
Page content Main links Local links User links Search Social links Footer What is this view?
Visual & Performing Arts
Logic will take you from A to B. Imagination will take you everywhere. ~Albert Einstein
Dance | Music | Theatre
Current CF Arts Brochure
2017 Spring Lecture Series
All lectures are free and open to the public.
Monday, Jan. 9, 12:30 p.m., Bldg. 4, Digital Lab, 4-205
"Digital Media and Design" by Zach Castedo
Castedo is a LEGO model designer at Merlin Entertainments and former digital media instructor.
Wednesday, Jan. 18, 12:30 p.m., Bldg. 4, Band Room, 4-122
"MusicReach Educational Outreach at UM" by Dr. Melissa Lesniak
Dr. Lesniak is director of outreach for the Donna Shalala MusicReach Program at the Phillip and Patricia Frost School of Music at the University of Miami. The lecture is funded by the Gladys Webber Memorial Chair.
Thursday, Jan. 19, 1 p.m., Dassance Fine Arts Center
"Of Ebony Embers" a lecture/demonstration by Core Ensemble.
Learn the "behind the scenes" of the show which will be presented this evening at 7:30 p.m.
Wednesday, Feb. 15, 12:30 p.m., Bldg. 4, Band Room, 4-122
"Life After the AA: Transferring to a Four-Year Institution" by Mutlu Citim-Kepic
Citim-Kepic is director of Music Admissions and Undergraduate Student Services at the University of Florida.
Wednesday, March 29, 12:30 p.m., Bldg. 4, Band Room, 4-122
"Growing Up Bel Canto: The Effects of the Italian Style and Repertoire on the Young Voice" by Wes Hunter
Tenor Wes Hunter will explore the vocal music of Rossini, Donizetti and Bellini in relation to how this repertoire and technique benefits young singers.
Students enjoy a rich experience learning, practicing and performing for the enjoyment of their audiences. CF boasts a bevy of award-winning productions and scholarship and competition winning students. Explore the links above, or view the calendar of events below. We look forward to you joining us in class or at one of our performances.
Visual and Performing Arts
Scholarships | Faculty and Staff | Frequently Asked Questions
The Arts at CF
- Acquire Tickets to CF Events
- Appleton Museum of Art
- Community Arts Partners
- Community School of the Arts
- Dassance Fine Arts Center
- Debra Vazquez Memorial Poetry Series
- Dinner Theatre at CF
- International Film Series
- Permanent Art Collection
- Second Sunday Film Series at the Appleton
- Student Publications
- Student Visual Arts
- Visual & Performing Arts Department
- Visual Artists' Society
- Webber Gallery
- CF Visual & Performing Arts Homepage
- Arts at CF Homepage


text:
Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors
Assays of multiple tumor samples frequently reveal recurrent genomic aberrations, including point mutations and copy-number alterations, that affect individual genes. Analyses that extend beyond single genes are often restricted to examining pathways, interactions and functional modules that are already known.
We present a method that identifies functional modules without any information other than patterns of recurrent and mutually exclusive aberrations (RME patterns) that arise due to positive selection for key cancer phenotypes. Our algorithm efficiently constructs and searches networks of potential interactions and identifies significant modules (RME modules) by using the algorithmic significance test.
We apply the method to the TCGA collection of 145 glioblastoma samples, resulting in extension of known pathways and discovery of new functional modules. The method predicts a role for
We have developed a sensitive, simple, and fast method for automatically detecting functional modules in tumors based solely on patterns of recurrent genomic aberration. Due to its ability to analyze very large amounts of diverse data, we expect it to be increasingly useful when applied to the many tumor panels scheduled to be assayed in the near future.
Tumor characterization projects are beginning to produce a large volume of data about genomic, epigenomic, and gene expression aberrations in tumor samples. This unprecedented volume of information has the potential to transform our understanding of cancer biology, reveal new biomarkers and drug targets, and accelerate the development of new cancer therapies. One recent genome-wide tumor characterization effort revealed recurrent somatic aberrations in 91 glioblastoma (GBM) tumors
A key question is how to extend integrative analysis of somatic genomic aberration data to expand known cancer pathways and interactions, or discover completely new modules (sets of related genes). Such inference has been done extensively using gene expression arrays, both in yeast and humans
Specifically, we focus on patterns of recurrent and mutually exclusive aberrations (RME patterns). Previous analyses of large tumor panels have discovered that alteration of genes comprising a specific functional module are often observed across a sample collection, but are almost never concurrently found in the same tumor. Examples of these modules include
The key insight is that these RME patterns may be used to identify groups of genes that are functionally related. This concept was explored in 2008 in the context of cancer by Yeang et al., who utilized data from the Catalogue of Somatic Mutations in Cancer (COSMIC) to identify functional relations among mutated genes
To address these issues, we developed a new method for detecting RME patterns, which we formalized by using structural reliability models
Figure 1
Overview of RME Module Detection
Overview of RME Module Detection. a) An example of a structural reliability model of progression of a particular tumor type. Cancer progression in this example requires aberrations in each of the three distinct functional modules (three horizontal lines). If mutated genes (crossed out in red) occur in all three modules, the connection between the left and right part of the structural model will be lost, indicating failure (cancer). b) A module may be disrupted by different aberrations in distinct tumor samples. One measure of an RME pattern is coverage, defined as the percentage of samples that contain at least one aberration within the module. Another measure of the pattern is exclusivity, defined as the percentage of covered samples that contain exactly one aberration within the module. An aberration in one of the genes within a specific RME module removes selective pressure of aberrations in other genes within the same module, giving rise to the exclusivity. c) Example network where nodes represent genes and edge thickness represents the level of exclusivity. The search for RME patterns starts by constructing such a graph using the Winnow algorithm. This graph indicates three potential RME modules. The node colors and numbers correspond to those in panel a. d) The significance score for RME patterns is dependent on both exclusivity (y-axis) and coverage (x-axis). Shown is the RME algorithmic compression score, d, for a three-gene RME module across 100 samples with aberrations equally distributed, assuming background frequency of 13.38 aberrant genes per sample (see section 2.3 andAdditional file
Creating a mutation matrix
We designed our algorithm to be capable of utilizing many disparate sources of mutational data, including single-nucleotide polymorphisms, copy-number alterations, and epigenomic modifications. In a pre-processing step, these diverse data types were converted into a single two-dimensional binary "mutation" matrix (Figure
Figure 2
Analysis Pipeline
Analysis Pipeline. In a preprocessing step, validated SNPs and focal CNAs are combined into a mutation matrix. This matrix is fed into the winnow algorithm, which scores each gene pair by exclusivity, indicated by edge scores in a graph. This graph is then searched for modules up to a specified size and the algorithmic significance is calculated for each potential module. Finally, the most significant modules are reported.
Data was obtained from the The Cancer Genome Atlas Data Portal (
Additional file 1
Supplemental Methods and Results.
Click here for file
These two forms of data were then merged into a two-dimensional mutation matrix. Each gene in each sample was checked against these single nucleotide and copy number mutations and a matrix was created such that if sample
Constructing a gene network with Winnow
The first step in our module detection pipeline was to filter the mutation matrix and retain only genes that meet a set frequency of recurrence, as genes altered in only one or a few samples do not contain enough information to calculate meaningful exclusivity scores.
A possible next step would be to calculate the exclusivity score between each pair of genes, defined as the number of samples where exactly one of the pair is mutated divided by the number of samples where at least one of the pair is mutated. (Figure
Thus, we used an online-learning linear threshold algorithm called Winnow to detect signals of exclusivity against the noisy background of passenger mutations in many irrelevant genes
The Winnow algorithm was run in an online setting, using one gene as a classifier and the rest of the mutation array as training data. In the first winnow run, all the bits in the array were flipped, such that we calculated how well each aberration in the classifier is predictive of non-aberration in each gene of the matrix. Then, we flipped the bits of the classifier, such that we calculated how well each non-aberration in the classifier was predictive of aberration in each gene of the matrix. The resulting weights were used to score the edges of the graph, then low-scoring edges were removed.
Since the range of weights for each run was determined by how quickly Winnow finds an optimal classifier, we did not use an absolute threshold value when removing edges. Instead, for each classifier gene, we took the second highest weight and retained all edges with a score greater than or equal to that value.
Identifying candidate modules
We then used each gene in the network as a starting point in a greedy local combinatorial search for RME modules, such that we evaluated all possible connected modules with size below the specified limit. We report those that have algorithmic significance above a predetermined threshold, based on the size of the input data (Figure
Evaluating modules by performing an algorithmic significance test
The problem of determining whether a module (subset of genes) contains a significant RME pattern of aberrations can be addressed using probabilistic models or heuristic scores. Both approaches would generally require establishment of extremely low significance values (pre-Bonferroni correction), which would in turn require many cycles of computationally demanding permutation testing. To eliminate this bottleneck, we employ a new implementation of the computationally much less demanding algorithmic significance test
The presence of an RME pattern (Figure
The algorithm then examines the sorted matrix row by row in a left to right order, keeping track of how many aberrations have been observed, and calculates a probability of observing an aberration in the next cell of the matrix and encoding the bit optimally according to the calculated probability. To describe how the probability is calculated, we first introduce additional notation. Let
Then, we can encode elements of X according to the following probability distribution: If
else we estimate that the probability is very low (but not equal to zero in order to avoid infinitely large penalties):
In contrast, the Null algorithm encodes optimally assuming that the
The encoding length difference between the null and RME algorithms and the algorithmic significance are calculated in the following two steps:
Step 1. Encode the binary aberration matrix.
where log denotes binary logarithm.
Step 2. Account for additional information (including implicit correction for multiple testing) and calculate significance.
Calculate significance value 2-
Whole-genome simulations
In order to benchmark the performance of this algorithm, we ran simulations on synthetic data sets. When generating sets with the same size as the current glioblastoma data (145 samples, 1290 genes), the actual distribution of mutations from the TCGA data was used to create random matrices. We simulated larger data sets using the knowledge that the current gene list is heavily biased towards known and frequently-altered oncogenes, so we compensated by assuming that 0.1% of newly considered genes will have a mutation frequency greater than 0.2, 0.9% will have frequency between 0.2 and 0.1, and 99% will have frequency less than 0.1.
We then used a binning procedure, where we started with the empirical GBM distribution, and calculated the proportion of mutations in each bin. To compensate for the fact that the distribution is heavily biased towards low-frequency mutations, we used bins of size 1% until we reached the tenth percentile, then used bins of size 5% to allow for some variability. We then distributed the specified proportion of aberrations randomly within each bin. We tested coverage levels between 50 and 100%, and generated RME Modules such that the number of alterations matched the given coverage level, exclusivity was 100%, and each gene was altered in a random number of samples that exceeded the minimum threshold.
Determination of prognostic significance
Affymetrix HG133-based GeneChip mRNA expression profiling data from two published datasets, the TCGA ("TCGA", n = 260) and the Erasmus Medical Center, Netherlands ("Erasmus", n = 153) were obtained as raw intensity files (.CEL files) and normalized
Implementation and availability
Implementation of the algorithm was done using Ruby and Bash. The core algorithm is available for download at
Discoverability of RME modules using current and anticipated TCGA project data
To determine how well our method detects RME modules over the background noise of passenger mutations, we ran experiments on synthetic data using several different parameter sets. As described in the methods, we created a randomized mutation matrix then added an RME module consisting of two to five genes. One thousand simulations were run for each parameter set to determine whether the seeded RME module could be detected. We measured sensitivity by the fraction of simulations where the seeded module was detected above the significance threshold. We measured precision by the fraction of simulations where the algorithm detected the seeded genes as more significant than any other module.
Genes altered in only a few samples did not contain enough information to calculate meaningful exclusivity scores, so we tested two different recurrence thresholds. When considering only genes that are altered in at least 10% of the samples, the algorithm had high sensitivity and precision, with smaller modules being more susceptible to false positives that arise by chance (Figure
Figure 3
Simulation Results
Simulation Results. One thousand simulations were run using varied numbers of genes and samples, for 5% and 10% recurrence thresholds. As sample size and the number of genes assayed increase, our algorithm retains the ability to detect RME modules with high sensitivity and precision.
We then evaluated the characteristics of pathways that are discoverable using the data that is to be generated by future stages of the TCGA project. We increased the number of samples to 500 and increased the number of resequenced genes to either the 6000 currently being evaluated in TCGA Phase 2, or the ~18000 that may be examined with whole-exome coverage (Figure
Comparison to other methods
We also compared the performance of our algorithm to previously published methods based on calculating p-values for exclusivity from a hypergeometric test or from a log-likelihood ratio
This can be explained as follows: The formula for calculating the likelihood ratio between the frequency of joint mutations relative to the best simpler model, as given in Yeang, is:
where the denominator is the empirical frequency of mutations in the first and second genes respectively, and the numerator is the empirical frequency of co-mutation. Thus, for two genes that are not mutated in the same samples, the likelihood ratio is 0 whether they each have one mutation, or they both have many mutations. Because of this characteristic, the likelihood method almost always reports false positive modules of genes that are exclusive by chance. Such modules usually have much lower coverage than the true seeded module. Since our algorithmic significance test considers recurrence as well as mutual exclusivity, it much more reliably excludes these false positives. The hyper-geometric p-value calculations described in Yeang suffer from a similar problem.
These other methods are also orders of magnitude slower than algorithmic significance, since they require many rounds of permutation testing to do multiple testing correction. Averaged across ten trials, the likelihood-based method had an average runtime of 899.377s, the hypergeometric method had an average runtime of 409.543s, and the algorithmic significance method had an average runtime of 0.779s. As described in the Methods section, algorithmic significance handles the problem of multiple testing using a penalty that takes very little time to compute. In contrast, both of the other methods require a step where the input data is permuted 1000 times and the number of combinatorial patterns is assessed. Unsurprisingly, this step makes these methods much slower.
Application to glioblastoma tumors
We next applied this method to data from genomic assays run on 145 primary GBM tumor samples, using a conservative recurrence threshold of 10%. The modules were ranked by their algorithmic significance scores. The top six modules listed in Figure
Figure 4
Pathway context for RME modules found in glioblastoma
Pathway context for RME modules found in glioblastoma. Genes colored red are recurrently mutated in such a way that we expect loss of function, and those colored green are amplified or contain putatively activating mutations. The d-score is the algorithmic significance value, with significance being equal to 2
Rediscovery and expansion of known modules
The highest-scoring rediscovered module consisted of alterations to the genes
We expect that alterations in any of these three module components would disrupt the tumor-suppressive activity of
We also observed that the pattern of regulation in this module is concordant with our knowledge about the tumor-suppressive activity of the
The second rediscovered module consists of the genes
The first module that does not directly map to a known pathway consists of the genes
Newly Discovered Modules
In addition to finding RME modules that are components of known pathways, we discovered modules that are previously unreported. Several have intriguing functional similarities, such as the pro-apoptotic roles of both
To show how one might leverage our gene module discovery process to produce clinically useful results, we decided to investigate EP300 further. Our method suggests that EP300 plays a role in the p53 pathway, which is strengthened by previous studies that show its interaction with
Figure 5
EP300 expression predicts survival for patients with glioblastoma
EP300 expression predicts survival for patients with glioblastoma. The role of
We have developed a sensitive, simple, and fast method for automatically detecting functional modules in tumors based on patterns of recurrent genomic aberration alone. The results indicate that integrative analyses of genome characterization data have the potential to identify groups of genes that have related roles in producing cancer phenotypes. Furthermore, it is possible to generate hypotheses about pathway membership, or about the functional relevance of unexpected or uncharacterized genes by using co-occurrence in an RME module as an indicator of function.
Our experiments do show that RME patterns are not perfect. The fact that 30-70% of samples are not covered by individual modules may be explained by several factors, including low-frequency mutations that fall below our recurrence thresholds, the small proportion of genes that were assayed for somatic point mutations, and lack of comprehensive epigenomic assays, which could give information on gene silencing. As the costs of massively parallel sequencing drop, we expect more complete coverage of a larger number of samples, which may resolve the first two issues. A larger number of genes are also slated to be assayed for abnormal methylation patterns soon, and this algorithm can incorporate such data into future analyses. These comprehensive whole-genome data will undoubtedly improve our ability to detect functional modules and eliminate any bias that comes from operating on a reduced gene set.
We also note that while our method does not use pathway, interactome, and other network information, we do not suggest this method as a complete replacement for analyses that do use these data. In fact, we envision extensions of this method that may use background knowledge in a controlled and explicit way. At this point, we also do not make use of aberration co-occurrence, which may suggest a lack of functional similarity. Such overlapping aberrations do not lend themselves to the same kind of clear and compelling interpretation as RME patterns, but may be nonetheless useful in future expansions of this method.
As the throughputs of technologies and the capacity of data producing projects increases, so will the significance and abundance of RME patterns. In anticipation of this trend, this method has been designed at the outset to accommodate an increasing diversity and volume of genome characterization information. We therefore anticipate that the method will be increasingly useful in generating hypotheses that will drive specific experiments and increase understanding of cancer progression.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
CM and AM: project conception, algorithm design. CM: implementation, simulations, and application. SS, ES, KA: survival analysis. CM and AM manuscript preparation. AM project leadership and supervision. All authors read and approved the final manuscript.
We gratefully acknowledge Dr. Pim J. French, Dr. Lonneke M. Gravendeel, and Dr. Peter S. Smitt of the Erasmus Medical Center, The Netherlands for providing raw intensity files for the Erasmus dataset. We also thank Dr. Chen-Hsiang Yeang of the Institute of Statistical Science of Academia Sinica for providing code that enabled us to do algorithmic comparisons.
The results published here are in whole or part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at
Funding: This research has been funded by the NIH grants R01-HG004009 and R21-HG004554 from the National Human Genome Research Institute and R33-CA114151 from the National Cancer Institute to AM.
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Cluster analysis and display of genome-wide expression patterns
Reverse engineering of regulatory networks in human B cells
A module map showing conditional activity of expression modules in cancer
Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression
Microarray reality checks in the context of a complex disease
Global Mapping of the Yeast Genetic Interaction Network
Mutations and addiction to
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Combinatorial patterns of somatic gene mutations in cancer
Introduction to Probability Models, Seventh Edition
Circular binary segmentation for the analysis of array-based DNA copy number data
Functional Copy-Number Alterations in Cancer
Learning Quickly When Irrelevant Attributes Abound: A New Linear-Threshold Algorithm
Discovering simple DNA sequences by the algorithmic significance method
Using markov models and hidden markov models to find repetitive extragenic palindromic sequences in Escherichia Coli
Statistical significance in biological sequence analysis
A Probabilistic Model of Local Sequence Alignment That Simplifies Statistical Significance Estimation
Textual data compression in computational biology: a synopsis
Discovering Dependencies via Algorithmic Mutual Information: A Case Study in DNA Sequence Comparisons
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Nonparametric estimation from incomplete observations
Regression models and life tables
p53, the cellular gatekeeper for growth and division
DNA-dependent acetylation of p53 by the transcription coactivator p300
Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
Beyond Grade: Molecular Pathology of Malignant Gliomas
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Delta Cycle Botticelli FS Bike Rack - $109.00
The Delta Botticelli FS (Free Standing) bike rack holds 4 bikes. Patent-pending Easy-Adjust(TM) arms adjust to accommodate any bike size. Easy assembly; all tools are included. Premium-quality powder-coat finish means years of service. Suitable for indoor or garage use. Maximum load: 120 lbs. - $109.00


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Happy Birthday, Mark Twain.
copyright © 2011 Wyatt Doyle
Wednesday, November 30, 2011
Thursday, November 24, 2011
"Thanksgiving at McDonald's in Times Square" by Josh Alan
To watch on YouTube, click the image above. To watch via Vimeo, click below.
Josh Alan's first 45.
To purchase your digital copy of the original "Thanksgiving at McDonald's in Times Square" single, click here.
© 1988, 2011 Josh Alan Friedman
Video by Wyatt Doyle & Josh Alan Friedman, with artwork by Drew Friedman. Visit DrewFriedman.net
Josh plays "Thanksgiving" live here.
Tuesday, November 1, 2011
All Crooked Birds
Jolie Routine, Dumbo
photo © 2011 Sarah Nankin
photo © 2011 Sarah Nankin
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Game View;
Bounty Hunter: Black Dawn "is a role-playing (RPG) fusion first-person shooter (FPS) games, game settings a bit special, RPG + FPS gameplay will give gamers a fresh feeling. The game has storyline, lots of challenging tasks and the BOSS, makes shooting game to play together more special. Has four career games, players can choose any one of them. There are 21 kinds of each occupation unique skills, you can choose one of nine kinds to equip your character. And to support multiplayer gaming, there are two modes 1V1 and 4V4.
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beryl raffa 21 Jul, 2013
Source: http://bbapk.blogspot.com/2013/07/free-download-bounty-hunter-black-dawn.html
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We, CEE India Manufacturing Company, have carved a niche in the market as a manufacturer, supplier, distributor, wholesaler, and trader of a wide range of Welding Equipment and other related products.
The product range offered by us encompasses Welding Cables, Welding Hose pipe, Welding Equipment & Machinery, Safety Equipment, Welding Electrodes etc.
Our products are fabricated using high grade raw material and advance technology that assure immense strength and durability to the structure. The products offered by us are available in industry-specific grades and other specifications, keeping the application requirement of the customers in mind. There are various other factors such as proficient team and robust infrastructure that enable us to design and develop products in accordance with the industrial parameters of quality and other related norms. We also make sure that these products are efficient, durable, high performing, corrosion resistant, and dimensionally accurate.
Manufacturing Quality Cables since 1996
The prime aim of our business endeavors is to offer premium quality products to the customers at competitive prices. For the same, we make use of high grade raw material for the product development process and advance technology to the processing of raw materials. We have a proficient team of engineers, supervisors, project managers, and skilled & semi-skilled labors to fabricate the products in compliance with the industrial norms of quality and other related parameters. These professionals ensure that the entire range is durable, efficient, and high performing.


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About Holly Energy Partners, L.P.:Holly Energy, headquartered in Dallas, Texas, provides petroleum product and crude oil transportation, tankage and terminal services to the petroleum industry, including HollyFrontier, a subsidiary of which currently owns a 42% interest (which includes a 2% general partner interest) in Holly Energy. If the transaction described in this release closes as anticipated, subsidiaries of HollyFrontier Corporation will own a 44% interest (including a 2% general partner interest) in Holly Energy. Holly Energy owns and operates petroleum product and crude pipelines, tankage, terminals and loading facilities located in Texas, New Mexico, Arizona, Oklahoma, Washington, Idaho, Utah, Kansas and Wyoming. In addition, Holly Energy owns a 25% interest in SLC Pipeline LLC, a transporter of crude oil in the Salt Lake City area. Information about Holly Energy Partners L.P. may be found on its website at http://www.hollyenergy.com. About HollyFrontier Corporation HollyFrontier Corporation, headquartered in Dallas, Texas, is an independent petroleum refiner and marketer that produces high value light products such as gasoline, diesel fuel, jet fuel and other specialty products. HollyFrontier Corporation operates through its subsidiaries a 135,000 barrels per stream day ("bpsd") refinery located in El Dorado, Kansas, a 125,000 bpsd refinery in Tulsa, Oklahoma, a 100,000 bpsd refinery located in Artesia, New Mexico, a 52,000 bpsd refinery located in Cheyenne, Wyoming and a 31,000 bpsd refinery in Woods Cross, Utah. HollyFrontier markets its refined products principally in the Southwest U.S., the Rocky Mountains extending into the Pacific Northwest and in other neighboring Plains states. Subsidiaries of HollyFrontier also own a 42% interest (including a 2% general partner interest) in Holly Energy. If the transaction described in this release closes as anticipated, subsidiaries of HollyFrontier will own a 44% interest (including a 2% general partner interest) in Holly Energy. Information about HollyFrontier Corporation may be found on its website at http://www.hollyfrontier.com. The following is a "safe harbor" statement under the Private Securities Litigation Reform Act of 1995: References in this statement to "we" or "our" refer collectively to HollyFrontier and Holly Energy. The statements in this press release relating to matters that are not historical facts are "forward-looking statements" within the meaning of the federal securities laws. Forward looking statements use words such as "anticipate," "project," "expect," "plan," "goal," "forecast," "will," "intend," "could," "believe," "may," and similar expressions and statements regarding our plans and objectives for future operations. These statements are based on our beliefs and assumptions and those of Holly Energy's general partner using currently available information and expectations as of the date hereof, are not guarantees of future performance and involve certain risks and uncertainties. Although we and Holly Energy's general partner believe that such expectations reflected in such forward-looking statements are reasonable, neither we nor Holly Energy's general partner can give assurance that our expectations will prove to be correct. Such statements are subject to a variety of risks, uncertainties and assumptions. If one or more of these risks or uncertainties materialize, or if underlying assumptions prove incorrect, our actual results may vary materially from those anticipated, estimated, projected or expected. Certain factors could cause actual results to differ materially from results anticipated in the forward-looking statements. These factors include, but are not limited to:
- the possibility that the proposed transaction is delayed or does not close, including due to HollyFrontier and Holly Energy failing to reach agreement on definitive terms, the inability of HollyFrontier and Holly Energy to obtain all approvals necessary or the failure of other closing conditions;
- risks and uncertainties with respect to the actual quantities of petroleum products and crude oil shipped on Holly Energy's pipelines and/or terminalled in Holly Energy's terminals;
- the economic viability of HollyFrontier, Alon USA, Inc. and Holly Energy's other customers;
- the demand for refined petroleum products in markets HollyFrontier and Holly Energy serve; and
- other risks and uncertainties detailed from time to time in HollyFrontier's and Holly Energy's Securities and Exchange Commission filings.


text: nice article was intersting to read. i just bought a bushmaster ar15. xm15 e2s model. and i have shot about 200 steel tula through it and about 300 brass. i have mostly brass in my ammo stock but have about 60 steel tula. if a shtf scenario i really wouldnt care if i was using brass or steel. for range ill shoot the cheapest stuff i can get. if it ruins my rifle in a few years ill buy 2 more.


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ED Magedson – Founder
Ripoff Report
FWM Labortories - Acai Berry Detox3007 Green Street Hollywood, Florida U.S.A.
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Take a look at our stuff
Going to a job day to day can be tedious when its not something you love. But here at Creative Colossal, we absolutely love design. Spending hours and days on something you love for happy clients is one of the most rewarding feelings a designer can have. Below is a few examples of our most recent projects.


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Crews with the City of Pocatello Street Operations Department will be sand sealing a section of Pocatello Creek Road Wednesday, May 25. Work will get underway around 6:30 a.m. and crews will be sealing Pocatello Creek Road from Booth Drive to the city limits. During the project, there will be single lane closures and flaggers will be on site to direct traffic in the construction area. Motorists are encouraged to use an alternate route to avoid the area if possible. Workers should complete the job the same day but in the event of inclement weather or unforeseen circumstances, the schedule may be revised. Officials would like to thank the public for their understanding and cooperation.


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Children's - Sunflower Russian Giant by Thompson and Morgan seeds. I could be the tallest flower in your garden. Can you grow the tallest, sunniest sunflower? When I have finished flowering leave the flower heads out to feed the birds over the winter. Height: 2m+.
Did You Know? - Not all sunflowers are yellow or tall. Look for furry-looking teddy bear types, different colours and ones with several flowers on one stem.
Sowing Instructions
Sow me indoors from February to April. Fill some 7.5cm pots almost to the rim with some moist seed compost. Push 3 seeds into the centre of each pot and cover with the compost. Place in a warm place in a light position. Keep the pots well watered until my seedlings appear - about 7 days. Move the plants to a bright windowsill, water regularly until I am well grown.
Sow me outdoors from May to early June Choose where you want me to grow. Rake the ground so it is nice and fine and remove any big stones. Sow me 20mm deep and 40cm apart. Make sure the rows are 45-60cm apart.
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For indoor sown plants - when all risk of frost has gone, plant me outside somewhere sunny and well-drained.
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10 Brilliant World Records in Sports
Most of us have an idea of what a human being can seemingly achieve and very few times, do we get to see an astounding act pulled off by a human. In the world of sports, we have had such brilliant world records that made many people reassess what was considered humanly impossible earlier that now seemed possible.
Here is a list of 10 brilliant world records in sports:
Yelena Isinbayeva is one of the best pole vaulter the world has ever seen. With 20 world records (9 of them were set in 2005) she went almost unbeaten in the Olympic Games of 2004. Pole vaulting in the late 1990s was said to be revolutionised by Emma George by pushing the world record from 4.23m to 4.60m in about four years. But Isinbayeva, in July 2005, became the champion of champions by passing 5m record (becoming the first woman to do so) and a month later she touched 5.01 m.
You May Also Like: Top 10 most Inspirational Athletes of All time
In 1984, when the wind was blowing high Uwe Hohn Javelin made an astounding throw of 104.80m. That day Hohn set a record of being the first man to throw the javelin more than 100m. It is a rare world record. And what followed next made this record an 'eternal world record'. The surprisingly vast distance that the javelin covered prompted the IAAF to redesign the javelin to purposefully under-perform.
You May Also Like: Top 10 Most Popular Athletes in the World
In the Olympic Games of 1988, American sprinter Florence Griffith-Joyner won 3 gold medals in the 100m, 200m & 4x100m relay. She was known as a 200m runner, but when she made a record of 10.49 in 100m in the quarter-finals of the US Olympic Trials, the world was stunned. Earlier that day she had run 10.60 which would have been considered a record had the winds not favoured her. Shattering the world record by an incredible 0.17 seconds was one of the most phenomenal achievements in athletics history.
You May Also Like: 10 Athletes with Terrible Criminal Records


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Welcome to The Kitchen Pantry!
The Kitchen Pantry is Canon City's Premiere Commercial Kitchen for homemade product production and cooking classes! Call The Kitchen Pantry at 719-357-1796 to book our space and follow us on Facebook for more information.
The Kitchen Pantry is the perfect place for:
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- Baking breads, cakes and other baked goods for fundraisers or to sell in The Kitchen Pantry retail store
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- Creating FDA approved labels
- Entrepreneurs wanting to start their own business
- Caterers needing kitchen space to rent
- Group cooking and food competitions
- Cooking, dinner and birthday parties
- Cooking and preserving classes
- All types of food production
For more information please see this video:


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Round Diamond rug
- Product range:
- Emma Elizabeth
- Supplier:
- Designer Rugs
Designed by Emma Elizabeth this rug is handmade from New Zealand wool and viscose, and can be custom made to any size and colour.
It was a winning entry in the Evolve Awards 2010, and is now part of the running I.D. collection.
All designs in the I.D. Collection are limited to an edition of 30 pieces per design and are available in the standard sizes of 200 x 300cm and 250cm dia. Designs can be custom coloured and sized upon application.
Round Diamond is suitable for commercial and residential interiors.
Request more information
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Itch (disambiguation)
From Wikipedia, the free encyclopedia
|Look up itch in Wiktionary, the free dictionary.
An itch is an unpleasant sensation that evokes the desire or reflex to scratch
Itch or Itching may also refer to:
- Jonny "Itch" Fox, British musician
- "The Itch" (House), an episode of the US TV series House
- Itch (EP), a 1994 Radiohead EP
- Itch (Kim Mitchell album), a 1994 solo album by Kim Mitchell
- "Itchin'", a single by Jimmy Jones
- ITCH (gene), an ubiquitin-activating enzyme
See also[edit]
- itch.io, an online videogame distribution marketplace
- Eetch, a traditional Armenian side dish made principally from bulgur
|This disambiguation page lists articles associated with the title Itch.
If an internal link led you here, you may wish to change the link to point directly to the intended article.


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CnD is a software that is made to demonstrate thermal analysis and design calculations required for designing shell and tube condensers. This software can design, horizontal shell side condensers, horizontal tube side condensers, vertical shell side condensers, vertical tube side condensers and reflux condensers.
This software tool is made to demonstrate the thermal design calculations and analysis of Kettle type reboilers. The software is user friendly and can be used to make preliminary sizing calculations that will help to give a clear outlook of the initial design.
Composite Design for Autodesk Revit 2014 is a program that enables you to perform basic structural analysis and design calculations of composite steel beams in a Revit Structure model. You can quickly design and check the behavior of composite beams or you can design an entire composite floor system on a floor by floor basis within a single Revit Structure model.
Combined3D is a general purpose spread and combined (two load points on a single footing) foundation design software for use on many different types of foundation design projects.
Whether you are designing foundations for your industrial, residential or other commercial projects, Combined3D will help you complete them in minutes.
It is to design reinforced concrete pile cap (in rectangular shape with main bar and secondary bar direction perpendicular to each other) and determine each pile load for a designed pile group, which is arranged either in symmetrical and unsymmetrical for either/both axis, with an axial compressive column load with or without bending moment.
GROUP has been well accepted as an useful design tool for analyzing the behavior of piles in a group subjected to both axial and lateral loadings. The program was developed to compute the distribution of loads (vertical, lateral, and overturning moment in up to three orthogonal axes) applied from any multiple locations in the pile cap to piles arranged in a group.
Condenser design (CnD) is a software tool that is made to demonstrate the thermal design calculations of Shell & Tube condensers. The software can design, horizontal condensers, vertical condensers including reflux condensers. Many features....etc
The Steam97 Excel Add-In library calculates 30 thermodynamic and transport properties of water and steam in SI and English units. It allows 16 different combinations of input variables to be used for calculations. The library is fully integrated in Excel, and available functions can be used in the same way as any other Excel function.
GWTools Excel Add-In is an add-in for Excel that provides specialized functions commonly used in hydrogeology. As an add-in, you need not copy the data to prescribed locations nor enable any macros. Nor are any extra worksheets required to process the data. All calculations are done quickly and efficiently just as with any other Excel function.
TraceCalc Pro TM is a Windows desktop application that provides heat-tracing design calculations for heat management systems.TraceCalc Pro also allows custom reports to be created depending on your specific needs. It is recommended that the user should be experienced in the design of heat tracing applications before using TraceCalc Pro.
DerivaGem is Excel-based.
Main features:
- It now carries out calculations for credit derivatives and interest rate derivatives, as well as for options on stocks, indices, currencies, and futures
- It calculates prices, implied volatilities, and the Greeks etc.
MicroSurvey CAD 2014 is a powerful desktop survey and design program that can be used by surveyors, contractors and engineers. The program includes features such as Complete Survey Drafting, COGO, DTM, Traversing, Volumes, Contouring, Point Cloud manipulation and Data Collection.
A comprehensive suite of tools to perform your electrical design calculations:
- Conduit fill
- Conductor sizing
- Motors
- Transformers
- Power factor
- Voltage deop
- Fault current
- Box fill and sizing
- Lighting design
- Panel Directories
- Quick reference tables
- Custom conductors
- Detailed reports
- Full NEC Compliance
AMETank enables the rapid configuration, design, and detailing of above-ground shop-built and field-erected storage tanks. The program features design calculations conform to API 650. Calculations include seismic, internal and external pressures, and wind loading.
FireCAD SuperHeater design module is a windows based user friendly design software. Using this module, Engineers can design SuperHeater for Fired Boilers, Waste Heat Boilers, HRSGs and for other hot gas sources of Chemical plants.
Main features:
- Extensive Waste gas database is provided. Users can select any listed gas from database or add their custom gases to database.
Electrc 2014 is a set of tools for electrical design calculations. It can be used for various applications such as conduit fill, conductor sizing, motor selection, transformer selection, power factor calculation, voltage drop measurement, fault current, etc.
A software Research Express runs a Microbiology Reader Bioscreen C, generates microbiological growth curves (turbidity versus time graph) and performs microbiological calculations. Microbiological growth data is collected directly into MS Excel workbook, to more than 20 graphical and microbiology formula sheets.


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Имена участников (разделяйте запятой).
Тема в разделе "Archive", создана пользователем john, 6 дек 2011.
do innova make events like double xp weekend,rabit event etc like ncsoft did?
they rly hard working to fix everything and make us happy while we play
so please be patient and wait till server goes live ;>
hopefully they will not. only standard events without free dynasty weapons or 2x exp, was good on dead ncshit servers.
i like the rabit event so you can get lot atribute stone.
question redirected to innnova team . make sure to check this for answers: https://forum.4game.com/showthread.php?t=752
closing old/inactive thread.
for information: events will be announced here - https://forum.4game.com/forumdisplay.php?f=17
past events that are no longer running can be found here - https://forum.4game.com/forumdisplay.php?f=129


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Episodes (BBC2) | iPlayer
Thalidomide: The Fifty Year Fight (BBC2) | iPlayer
Vikings (History Channel) | History
Coast Australia (BBC2) | iPlayer
Episodes shouldn't, perhaps, work. The tale of a husband-wife writing team (Stephen Mangan and Tamsin Greig) who are persuaded, with a refreshing lack of reluctance, to sell out and take their fictionally Bafta-winning (and very British) comedy to Hollywood, thence to have it "made over" with gleeful disregard for such restrictive critical concerns as, for instance, taste – is surely too close to the experiences of many homegrown authors and film-makers for the memories to be anything other than vile at best. The Greig/Mangan original comedy, for instance, fictionally starred Richard Griffiths as a tweedy teacher in his twilight: transposed, the writers are both starstruck and horrified to find the grinsome Matt LeBlanc, Joey from Friends, in his place.
But it does work – and how. Partly through the subtlety of the writing, by Jeffrey Klarik and his partner David Crane, also of Friends fame: Friends, of course, wasn't written with British audiences in mind, but might as well have been, and its appreciation of "our" sense of humour (and our preconceptions about how the Americans could never quite "do" it) meant it became a crossover dream. As Episodes is now proving: it's been garnering much critical praise over there. Partly, too, thanks to the chemistry between Greig, Mangan and Matt LeBlanc, who's playing a lightly fictionalised version of "Matt LeBlanc" – kindly, vainglorious, deeply shallow to the extent that he has drunkenly invited his crazed stalker into his bed.
And one of the simple delights lies in seeing how far Tamsin Greig has come, from stoic work as Debbie Aldridge in The Archers, to a revelatory gift for comedy as Fran in the sublime Black Books, to – ta-dah! – sunny La-La-Land: Toto, we're not in Ambridge any more. This is just telly that makes you smile. Incidentally, one of the gags involves Matt, arrested on a borderline DUI charge, to be met with a beaming desk-sergeant who proudly boasts that his sister was nurse No 4 or something in one Friends episode. Matt does his winning best to pretend to remember her. (He's still booked.) On Good Morning Britain the other day, Matt popped up, only to have Ben Shephard remind him that he, Ben, had once "played" an interviewer in one Friends episode. Matt did his winning best to pretend to remember him. A trouper.
I can't see a facile link, my usual speciality, from smilegood telly to the most harrowing documentary of the week, so I'll just say quiet thanks again for the fact I wasn't a thalidomide baby, as I was smack-bang in the at-risk group. Thalidomide: The Fifty Year Fight told many stories about this, the worst disaster ever inflicted by medicine, but chiefly that of David Mason, whose baby daughter Louise he first met as "a torso with little… little flowers… where her arms and legs should be."
It was a tough call (it was a tough watch) over who suffered the worst unwarranted repugnance – the children, the mothers, David himself? But the mothers, I think: not only heartbroken, and with severely disabled babies, later children, to care for daily, but also facing perennial guttersniping from neighbours, "friends", family about how it had been the mother's fault. There were suicides. Those were no less kind days: in some areas, significantly worse.
I had never understood the grim specificity of thalidomide's effects on a newly pregnant mother. Take a pill on day 20, and the baby was likely to suffer central brain damage. Day 21 – eyes. Day 22 – ears, face. Day 24 – upper limb damage. In one day, the taking of one little tablet, famously marketed just to ameliorate morning sickness, was capable of rewiring the genome code for, say, a complete set of arms. And David Mason suffered in a differently cruel way: his own lawyers ganged up on the establishment side against him and he was vilified by fellow parents of thalidomide sufferers for refusing to give up his battle against Distillers Company, who'd marketed the German drug in Britain without sufficient testing. There were tears, near fights, as these people, who had suffered so much, bickered violently over whether to take the early derisory settlement or, David's choice, hold out. With the help of the Sunday Times, and Ralph Nader – I have to say clever Harry Evans, seen here in his finest moment, has aged better – David won. This was the ugly story of a good battle: of a man of principle, and fine journalism, and a feisty proprietor: Rupert was fresh enough off the boat to still loathe the establishment, and unleashed a splenetic guerrilla poster campaign against Distillers, and there was a result. But cases continue.
Vikings is hokum, but terrific hokum. The tale of the handsome Ragnar Mufflebeard or some such, and his rebellious dreams of travelling westwards, where the sun sets, it features longships, crossbows, sunstones, sunboards, gore, looting, roasting-halls and plaited maidens, and is as loosely based on the true Viking story as were the Mr Men books on the writings of Gertrude Stein. So far, though, it's marvellous fun.
Coast made, in its nine charming domestic years, demi-semi stars down the pub of the likes of Neil Oliver, Miranda Krestovnikoff, Alice Roberts and Nicholas Crane's umbrella. Not quite Hollywood A-listers, however – yet it was one of those, Mr Billy Bob Thornton (currently continuing to wreak delightfully wicked havoc over in Fargo) to whom my strange mind was unerringly drawn, specifically a quote of his in the movie Armageddon. "Well," he tells the president, as the meteor looms, "our object collision budget's a million dollars, that allows us to track about 3% of the sky, and, begging your pardon sir, but it's a big-ass sky out there." Australia is frankly a big-ass continent. So why, when Coast Australia is on for just under an hour, did they allow Neil Oliver to timewaste with a full 5.22 minutes of foreplay-filler-guff before the nice theme tune even schlepped in?
We know what it is. It's Coast. Gone to Australia. Not that hard to get one's head around, certainly not as hard as getting your head around the impossible skies, nor the setting sun over the Kimberley, for which a new colour-word and several new adjectives must urgently be invented. Nor frankly the glowing pulchritude, furnish'd and burnish'd by Adelaide sun, of forensic anthropologist Xanthé Mallett, just one of a cracking new team of specialists: so just let us get on with watching the bloody stuff.
This was absorbing – but, don't come the raw prawn with me, it was basically travel porn. Crucial difference is most of us had a faint chance of going to the domestic Coast places, and few have the chance, as is the lot of Xanthé and co, to view these forlorn otherwordly landscapes in real time, with shorts and a tinny. But I flew to Broome once, in a tiny plane, and watched all this with both joy and lump-in-throat heartache.


text: LAS VEGAS, March 20, 2012 /PRNewswire/ -- Pinnacle Entertainment, Inc. (NYSE: PNK) announced today the election of Desiree Rogers and Jaynie Miller Studenmund to the Company's Board of Directors effective March 19, 2012. Ms. Rogers is chief executive officer of Johnson Publishing Company, LLC. Ms. Rogers joined Johnson in August 2010, and has revitalized the company's EBONY and JET magazine brands, and its Fashion Fair Cosmetics business. Prior to joining Johnson, Ms. Rogers served as Special Assistant to the President of the United States and Social Secretary of The White House. Ms. Rogers holds a B.A. in Political Science from Wellesley College and an M.B.A. from Harvard Graduate School of Business Administration. Ms. Studenmund's current corporate boards include Orbitz Worldwide, Inc., Western Asset, Forest Lawn Memorial Parks, and until recently, eHarmony and MarketTools. Ms. Studenmund brings over 30 years of executive operating experience in the internet and financial services industries. Her last position was the chief operating officer for Overture Services, Inc., the creator of paid search, which is today the dominant form of online advertising. Overture was acquired by Yahoo! in 2004. Ms. Studenmund also served as president and chief operating officer of PayMyBills.Com as well as executive vice president for retail and executive committee member of First Interstate Bank. Ms. Studenmund holds a B.A. in Economics from Wellesley College and an M.B.A. from Harvard Graduate School of Business Administration. The addition of Ms. Rogers and Ms. Studenmund expands the number of directors on the Company's board from seven to nine directors. As previously disclosed, Lynn P. Reitnouer is retiring from the Company's Board of Directors following the conclusion of the 2012 Annual Meeting of Stockholders and the Company's Board of Directors will be reduced to eight members following the conclusion of the 2012 Annual Meeting of Stockholders. Richard Goeglein, chairman of Pinnacle Entertainment's Board of Directors, commented, "On behalf of our board, I would like to thank Lynn Reitnouer for over 20 years of service to Pinnacle Entertainment as a member of the Company's Board of Directors. Lynn has made significant contributions to the board's deliberations and will be greatly missed in the boardroom after his retirement. I am also very pleased to welcome Desiree and Jaynie to the Company's board. The experience of these two very highly accomplished individuals strengthens our board and improves its composition with the addition of two independent members." Anthony Sanfilippo, president and chief executive officer of Pinnacle Entertainment, commented, "Desiree adds depth to our current board with over 25 years of experience in marketing and operational roles in consumer-centric businesses and recent success revitalizing the core brands of Johnson Publishing. Her prior experience in the gaming industry as director of the Illinois Lottery will bring unique experience to our board. "Jaynie has over 30 years of comprehensive executive management and operating experience across a diverse set of businesses, including start-ups, rapid growth, turnarounds and mergers and acquisitions in the internet and financial services industries, making her a valuable addition to the board. Within these environments, she has served as a successful president, chief operating officer and director of both public and private companies."


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A new Downtown Cairo building discovery for me: The Credit Foncier Egyptien bank building or as it is known now as Arab international bank "AIB".
Built in 1903 in its current location, the Credit Foncier Egyptian or the Egyptian Credit Foncier bank was active till its nationalization in the 1950s.
Originally Founded by Karl Heinrich and Raphael Suares in 1880 in Alexandria, it predated the National Bank of Egypt "NBE" so yes it was the oldest and first bank in Egypt. Reading more about it the Credit Foncier Egyptien Banque represented the French interests whereas the NBE represented the British interest for dominance on the Egyptian economy then.


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Download: 7-Zip 4.62 - Powerful freeware file archiver
After a long time of development the new version 4.62 of the freeware archiver 7-Zip is available for download.
A couple of years ago nearly no Windows user could do without Winzip - the commercial software was the quasi-standard of all packing programs. Today numerous alternatives are available for free and their functionalities match the charged suites in almost every way.
7-Zip is not only for free but also an open source software and therefore in constant development. The small, fast and reliable tool unpacks all popular formats (from ZIP via RAR to ISO and CAB) and among other things compression into the ZIP format is possible. Furthermore a proprietary standard called 7z is supported. To some extent it offers an even higher compression ratio than the very efficient RAR.
7-Zip runs under all Windows versions from 98 to Vista. The download of the released final version 4.62 is available on the developer's website (Download 7-Zip 4.62) or directly on our server. The change log can be found here.
MSI Afterburner 4.3.0 Final: Geniales Tweak-Tool für Grafikkarten im Download


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The 26-year-old trained for a week and is gearing up to fight for a place in Sir Alex Ferguson's starting XI. Rooney suffered a nasty gash on his right thigh during the game against Fulham at Old Trafford.
In case he is not fit for the clash against Newcastle, he could well make the squad for the match against Tottenham on Saturday. But will Ferguson reshuffle his squad with Rooney's return?
Ferguson should be content with his sides performance so far in the new season. However, the win against Liverpool was unlike Red Devils usual style of play.
United's £24 million signing Robin van Persie, the Premier League's top-scorer so far with five goals in five games, has cemented his place upfront ahead of other strikers Danny Welbeck and Javier Hernandez.
Rooney was also dropped on the bench against Fulham last month, following a poor performance at Goodison Park which United lost 1-0 against Everton on opening day.
With four to five strikers fighting for a place upfront along side Van Persie, Rooney can only hope to find his best form sooner than later and convince Ferguson that he can still be a great threat to opponents.
OneIndia News


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Since 2010 the Dallas Cowboys have done a better job of finding talent. As a core of Tony Romo, Jason Witten, DeMarcus Ware, Miles Austin, Jason Hatcher, Anthony Spencer and Doug Free inch closer to the end of their careers, the Cowboys need a group of young players heading into their primes to take ownership of the team. Cowboys reporters Calvin Watkins and Todd Archer analyze those players from the class of 2010 on.
Dez Bryant emerged as the Cowboys' No. 1 offensive threat in 2013. He finished the season leading the team in catches (93), receiving yards (1,233) and first downs earned (62).
For his efforts, Bryant was named to his first Pro Bowl, and to think his numbers would have been better if not for a one-catch performance at New Orleans, three-catch day at Detroit and a few games where he wasn't targeted on several possessions.
Bryant also caught a touchdown pass in his last five games.
The biggest issues for Bryant going forward is how he deals with different types of coverages and how he handles his emotions.
Quarterback Tony Romo isn't one to just target a receiver for the sake of doing that -- he throws the ball to the open man -- hence the impressive 44-catch season by rookie Terrance Williams and the 39-catch effort by second-year receiver Cole Beasley in 2013. However, there are times when the Cowboys have to find ways to get Bryant open regardless of the coverage.
Moving him around the line of scrimmage is key and you can't use the excuse that Bryant doesn't know the offense, because he has a command of it, not like Miles Austin, but he's trustworthy enough for Romo to make adjustments with him on the fly.
Playcaller Bill Callahan has to get Bryant going early because he can have such a big impact in the game. But when it doesn't happen, this is where things go haywire.
Bryant's outburst in the loss at Detroit made national news, something he wasn't trying to do, and while it later was revealed Bryant was being a positive light on the sideline, the perception was he was out of control. Bryant is an emotional player and one of the tough guys on this team. Bryant, however, has to be mindful of how he acts on the sideline.
He's everything the Cowboys need and his future says he'll get a contract extension because at his age, 25, he's somebody this team needs to move forward.


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tranny mount squeaks when stepping on gas because the metal part of the tranny mount is rubbung on the crossmemeber(confirmed by both ford and tranny shop) and both say "that's just the way it is." Is this infact the case or am I right in thinking new mount? Also, have drive line vibs...can mount cause this as well? Lastly, what are the pinion angles suppose to be on rear drive shaft because my truck doesn't appear to have any.
(1) Answer
Start with having the transmission mount replaced, then see if the vibration and squeak goes away and unless someone changed the rear end the pinion angle should be fine.