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Liberation Coaches Pvt. Ltd.
No. of Franchise Outlets: 1
Investment: Rs. 5lac - Rs. 10lac
Liberation Coaches Pvt. Ltd. – Your opportunity to become a leading entrepreneur in education sector...Read On!
Liberation Coaches Pvt. Ltd. provides organizational solutions & transforms people through training, consultancy and coaching. We identify and provide solutions for the most critical and challenging problems that organizations face today.
This could be related to low morale, low performance, resistance to change, scattered documentation system, issues related to lack of teamwork, vision and leadership or human resources management issues. We provide end to end solutions for every organizational challenge using diagnostic & scientific tools, methods and training.
Founded on 4th April 2006, we are:
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Franchise Facts:
- Investment: Rs. 5lac - Rs. 10lac
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Liberation Coaches Pvt. Ltd. Team
Liberation Coaches Pvt. Ltd. Investment Details
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Liberation Coaches Pvt. Ltd. Training Details
Liberation Coaches Pvt. Ltd. Agreement & Term Details
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Challenge level:
What does the overlap of these two shapes look like? Try picturing it in your head and then use the interactivity to test your prediction.
Draw three straight lines to separate these shapes into four groups
- each group must contain one of each shape.
Can you work out what shape is made when this piece of paper is folded up using the crease pattern shown?
This practical problem challenges you to make quadrilaterals with a loop of string. You'll need some friends to help!
Can you cut a regular hexagon into two pieces to make a
parallelogram? Try cutting it into three pieces to make a rhombus!
What shape is made when you fold using this crease pattern? Can you make a ring design?
What shape is the overlap when you slide one of these shapes half way across another? Can you picture it in your head? Use the interactivity to check your visualisation.
Billy's class had a robot called Fred who could draw with chalk
held underneath him. What shapes did the pupils make Fred draw?
A group activity using visualisation of squares and triangles.
Can you visualise what shape this piece of paper will make when it is folded?
Have a go at making a few of these shapes from paper in different sizes. What patterns can you create?
Can you describe a piece of paper clearly enough for your partner to know which piece it is?
Can you fit the tangram pieces into the outline of Little Ming and Little Fung dancing?
Here's a simple way to make a Tangram without any measuring or
ruling lines.
A hundred square has been printed on both sides of a piece of paper. What is on the back of 100? 58? 23? 19?
Can you fit the tangram pieces into the outlines of the workmen?
A game for 2 players. Given a board of dots in a grid pattern, players take turns drawing a line by connecting 2 adjacent dots. Your goal is to complete more squares than your opponent.
If you split the square into these two pieces, it is possible to fit the pieces together again to make a new shape. How many new shapes can you make?
Can you fit the tangram pieces into the outlines of the lobster, yacht and cyclist?
What happens when you turn these cogs? Investigate the differences
between turning two cogs of different sizes and two cogs which are
the same.
This article looks at levels of geometric thinking and the types of
activities required to develop this thinking.
Can you fit the tangram pieces into the outline of these convex shapes?
Can you fit the tangram pieces into the outline of the child walking home from school?
If you can post the triangle with either the blue or yellow colour face up, how many ways can it be posted altogether?
These points all mark the vertices (corners) of ten hidden squares.
Can you find the 10 hidden squares?
Can you fit the tangram pieces into the outline of this goat and giraffe?
Can you fit the tangram pieces into the outline of this sports car?
Can you fit the tangram pieces into the outlines of the chairs?
Can you fit the tangram pieces into the outlines of the candle and sundial?
How can the same pieces of the tangram make this bowl before and after it was chipped? Use the interactivity to try and work out what is going on!
Use the three triangles to fill these outline shapes. Perhaps you can create some of your own shapes for a friend to fill?
A shape and space game for 2,3 or 4 players. Be the last person to be able to place a pentomino piece on the playing board. Play with card, or on the computer.
You have been given three shapes made out of sponge: a sphere, a cylinder and a cone. Your challenge is to find out how to cut them to make different shapes for printing.
Can you arrange the shapes in a chain so that each one shares a
face (or faces) that are the same shape as the one that follows it?
An extension of noughts and crosses in which the grid is enlarged
and the length of the winning line can to altered to 3, 4 or 5.
Each of the nets of nine solid shapes has been cut into two pieces. Can you see which pieces go together?
Investigate how the four L-shapes fit together to make an enlarged L-shape. You could explore this idea with other shapes too.
Here are shadows of some 3D shapes. What shapes could have made
Can you fit the tangram pieces into the outlines of the watering can and man in a boat?
Can you fit the tangram pieces into the outlines of Mai Ling and Chi Wing?
Which of these dice are right-handed and which are left-handed?
Can you fit the tangram pieces into the outline of this shape. How would you describe it?
Investigate the number of paths you can take from one vertex to
another in these 3D shapes. Is it possible to take an odd number
and an even number of paths to the same vertex?
Where can you put the mirror across the square so that you can still "see" the whole square? How many different positions are possible?
Reasoning about the number of matches needed to build squares that
share their sides.
A game for two players. You'll need some counters.
What is the total area of the four outside triangles which are
outlined in red in this arrangement of squares inside each other?
Think of a number, square it and subtract your starting number. Is the number you're left with odd or even? How do the images help to explain this?
What shape has Harry drawn on this clock face? Can you find its
area? What is the largest number of square tiles that could cover
this area?
I've made some cubes and some cubes with holes in. This challenge invites you to explore the difference in the number of small cubes I've used. Can you see any patterns?

subset: commoncrawl


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And in this modern generation people get tattoos on their body parts for their life styles and some people get tattoos on their body not only for style but also for different believes.
And in these generations tattoo has become the new style of fashion for fashion lovers for both men and women. The beauty of tattoo is not the design only but the placement of tattoos should be in the right place.
Due to the thin and sensitive skin of the girls, it has to be very careful for the artist while making tattoo on their body. And as the skin of the girls are very sensitive, making tattoos in the lower back tattoos for girls is little bit risky but it looks pretty cool and looks very beautiful in the lower back part of the body.
Some of the Merits of lower back tattoos for girls are:
- One of the most important things of making tattoo is the design of the tattoo and where to place that design on your body parts because the tattoo should look attractive, interesting and beautiful too.
- And another best thing is that in the lower back part of the body there is a lot of free space which you will be able to make the tattoo very wide and large which will make the tattoo very attractive and visible to the people.
- And another main advantage for making tattoos on the lower back part of the body is that tattoo can be hidden easily and while going to office or any interview for jobs you can easily hide it if you don't want to show your tattoo then lower back tattoo is the best place for the girls to make tattoo.
- The Design with round shape is normally one of the most popular tattoos for girls and the lower back part of the body is the best place for that type of tattoos.
- As designing the tattoos there is a no risk about someone to give attention on the tattoos, and it is good to have the lower back tattoos other than any other parts of the body.
Along with the advantages, there is also a disadvantage of lower back tattoos for girls:
- As the skins of the girls are very sensitive, it has to be very careful for the artist while making tattoo on their body.
- Making tattoos in the lower back body parts of the girls may also leads to side effects. It might lead to different type of dangerous diseases like skin disease, skin cancer, blood cancer, etc.
- As the skin of the girls are much sensitive as compared to boys they can't bear the pain while making tattoo and the tattoo may become invisible after few years if it is not properly done by the artist, So it is very important for the girls to bear the pain otherwise it may become vanished after some few years.
Some of the popular designs of lower back tattoos for girls are given below:
- Bird design:
This is one of the best popular designs for the girls in their lower back part of the body.
- Tribal design:
This type of design is mainly done by the girls who believe in cultural and traditional identification.
- Flower design:
Flower is also one of the most popular designs of lower back tattoos and it refers the meaning of beauty.
There are many more designs which will make your tattoo attractive and you can find thousands of images for the lower back portion of the girl's body in every tattoos website.
As the skin of the girls are very sensitive and it might leads to some dangerous diseases also. So while making tattoos you need to be very careful and If you are very interested in making tattoos and arts you can do that but make sure that they give you some safety precautions while making your tattoo. And if want you can freely give comment and share your feelings about tattoos.


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|"Gary Tully (JIRA)" <j...@apache.org>
|[jira] Commented: (AMQ-2826) Look at the possibility of incorporating a cassandra persistence adapter from http://github.com/ticktock/qsandra
|Thu, 15 Jul 2010 10:25:52 GMT
[ https://issues.apache.org/activemq/browse/AMQ-2826?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=60674#action_60674 ] Gary Tully commented on AMQ-2826: --------------------------------- Sure, it is of interest, what is the 1.6 dependency, any chance that it can be worked around? > Look at the possibility of incorporating a cassandra persistence adapter from http://github.com/ticktock/qsandra > ----------------------------------------------------------------------------------------------------------------- > > Key: AMQ-2826 > URL: https://issues.apache.org/activemq/browse/AMQ-2826 > Project: ActiveMQ > Issue Type: New Feature > Components: Message Store > Affects Versions: 5.3.2 > Reporter: Scott Clasen > > I am the author of http://github.com/ticktock/qsandra, which is a cassandra persistence adapter for activemq. I am willing to donate it if it is something that is of interest to ActiveMQ.. > Only current trouble with that is it needs JDK 1.6, so it would probably need to wait until (if and when) ActiveMQ 5.x is built with JDK 6. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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Stone Ruination IPA was the first full-time brewed and bottled West Coast double IPA on the planet. As craft beer has evolved over the years, so too have techniques for maximizing hop flavors and aromas. For the second incarnation of our groundbreaking India pale ale, we employed dry hopping and hop bursting to squeeze every last drop of piney, citrusy, tropical essence from the hops that give this beer its incredible character. We've also updated the name to reflect the imperial-level intensity that's evident in every sip. Join us in cheering this, the second stanza in our "Liquid Poem to the Glory of the Hop."Paganism at its best!
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Local deliveries are available in the Glasgow area for orders over £20. Deliveries are every Wednesday from 6pm to 9pm. Orders must be received by 10pm on Tuesday. To check if your postcode qualifies please refer to the Local Deliveries spreadsheet.
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We are an independent boutique retailer who fulfil online orders directly from shop stock. Occasionally items purchased online may be unavailable if sold in-store that day. In such cases a member of our in-store team will contact you to recommend a suitable alternative from our range or offer a refund.


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SJ Berwin EU and competition head Stephen Kon has won the race to be the firm's next senior partner, defeating litigation partner Hilton Mervis in a two-man contest.
Kon will take over on 1 May, replacing Jonathan Blake after the funds partner spent two three-year terms in the role.
Blake decided last month not to stand for a third term, with Kon widely tipped as a likely successor (3 February 2012).
SJ Berwin was originally expecting to announce the result by the end of March, but the fact that there were only two candidates and no need for a second round of voting meant the result could be announced today (14 March 2012).
Kon, one of the firm's most senior figures, was the favourite for the role, with Mervis – who also stood unsuccessfully for managing partner in 2010 – seen as an underdog (16 February 2012).
He surprised the market last year by quitting SJ Berwin to join Milbank Tweed Hadley & McCloy but was persuaded to stay on (14 July 2011).
Kon has been elected for a three-year term, with the partnership agreement requiring another poll every three years. There is no limit to the number of terms a senior partner can serve.
It follows corporate partner Rob Day's election as managing partner in 2010 following a three-way contest (1 November 2010).
Kon follows in the footsteps of Herbert Smith senior partner Jonathan Scott, another competition partner running a top 20 UK firm.
Kon said in a statement: "I'm very proud of this firm and everything we've achieved over the last 30 years. Our success is attributable to the quality of the people in our firm and the deep relationships we enjoy with our clients. I'm focused on driving the firm forward to achieve its full potential with energy, enthusiasm and determination."
Day commented: "[Kon] is a man of great experience, authority, judgment and integrity. I'm really looking forward to working closely with him to continue to develop this great business."


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A large proportion of human T cells are autoreactive to group 1 CD1 proteins, which include CD1a, CD1b, and CD1c. However, the physiological role of the CD1 proteins remains poorly defined. Here, we have generated a double-transgenic mouse model that expresses human CD1b and CD1c molecules (hCD1Tg) as well as a CD1b-autoreactive TCR (HJ1Tg) in the ApoE-deficient background (hCD1Tg HJ1Tg
Sreya Bagchi, Ying He, Hong Zhang, Liang Cao, Ildiko Van Rhijn, D. Branch Moody, Johann E. Gudjonsson, Chyung-Ru Wang
Despite the benefit of insulin, blockade of autoimmune attack and regeneration of pancreatic islets are ultimate goals for the complete cure of type 1 diabetes (T1D). Long-term consumption of ω-3 polyunsaturated fatty acids (PUFAs) is known to suppress inflammatory processes, making these fatty acids candidates for the prevention and amelioration of autoimmune diseases. Here, we explored the preventative and therapeutic effects of ω-3 PUFAs on T1D. In NOD mice, dietary intervention with ω-3 PUFAs sharply reduced the incidence of T1D, modulated the differentiation of Th cells and Tregs, and decreased the levels of IFN-γ, IL-17, IL-6, and TNF-α. ω-3 PUFAs exerted similar effects on the differentiation of CD4+ T cells isolated from human peripheral blood mononuclear cells. The regulation of CD4+ T cell differentiation was mediated at least in part through ω-3 PUFA eicosanoid derivatives and by mTOR complex 1 (mTORC1) inhibition. Importantly, therapeutic intervention in NOD mice through nutritional supplementation or lentivirus-mediated expression of an ω-3 fatty acid desaturase, m
Xinyun Bi, Fanghong Li, Shanshan Liu, Yan Jin, Xin Zhang, Tao Yang, Yifan Dai, Xiaoxi Li, Allan Zijian Zhao
Genetic variations in the
Mohd Hafeez Faridi, Samia Q. Khan, Wenpu Zhao, Ha Won Lee, Mehmet M. Altintas, Kun Zhang, Vinay Kumar, Andrew R. Armstrong, Carmelo Carmona-Rivera, Jessica M. Dorschner, Abigail M. Schnaith, Xiaobo Li, Yogita Ghodke-Puranik, Erica Moore, Monica Purmalek, Jorge Irizarry-Caro, Tingting Zhang, Rachael Day, Darren Stoub, Victoria Hoffmann, Shehryar Jehangir Khaliqdina, Prachal Bhargava, Ana M. Santander, Marta Torroella-Kouri, Biju Issac, David J. Cimbaluk, Andrew Zloza, Rajeev Prabhakar, Shashank Deep, Meenakshi Jolly, Kwi Hye Koh, Jonathan S. Reichner, Elizabeth M. Bradshaw, JianFeng Chen, Luis F. Moita, Peter S. Yuen, Wanxia Li Tsai, Bhupinder Singh, Jochen Reiser, Swapan K. Nath, Timothy B. Niewold, Roberto I. Vazquez-Padron, Mariana J. Kaplan, Vineet Gupta
B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell–specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet–expressing B cells may be a potential target for therapy for autoimmune diseases.
Kira Rubtsova, Anatoly V. Rubtsov, Joshua M. Thurman, Johanna M. Mennona, John W. Kappler, Philippa Marrack
MicroRNAs (miRs) are tightly regulated in the immune system, and aberrant expression of miRs often results in hematopoietic malignancies and autoimmune diseases. Previously, it was suggested that elevated levels of miR-27 in T cells isolated from patients with multiple sclerosis facilitate disease progression by inhibiting Th2 immunity and promoting pathogenic Th1 responses. Here we have demonstrated that, although mice with T cell–specific overexpression of miR-27 harbor dysregulated Th1 responses and develop autoimmune pathology, these disease phenotypes are not driven by miR-27 in effector T cells in a cell-autonomous manner. Rather, dysregulation of Th1 responses and autoimmunity resulted from a perturbed Treg compartment. Excessive miR-27 expression in murine T cells severely impaired Treg differentiation. Moreover, Tregs with exaggerated miR-27–mediated gene regulation exhibited diminished homeostasis and suppressor function in vivo. Mechanistically, we determined that miR-27 represses several known as well as previously uncharacterized targets that play critical roles in controlling multiple aspects of Treg biology. Collectively, our data show that miR-27 functions as a key regulator in Treg development and function and suggest that proper regulation of miR-27 is pivotal to safeguarding Treg-mediated immunological tolerance.
Leilani O. Cruz, Somaye Sadat Hashemifar, Cheng-Jang Wu, Sunglim Cho, Duc T. Nguyen, Ling-Li Lin, Aly Azeem Khan, Li-Fan Lu
Alterations in the apoptosis of immune cells have been associated with autoimmunity. Here, we have identified a homozygous missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 (
Michel J. Massaad, Jia Zhou, Daisuke Tsuchimoto, Janet Chou, Haifa Jabara, Erin Janssen, Salomé Glauzy, Brennan G. Olson, Henner Morbach, Toshiro K. Ohsumi, Klaus Schmitz, Markianos Kyriacos, Jennifer Kane, Kumiko Torisu, Yusaku Nakabeppu, Luigi D. Notarangelo, Eliane Chouery, Andre Megarbane, Peter B. Kang, Eman Al-Idrissi, Hasan Aldhekri, Eric Meffre, Masayuki Mizui, George C. Tsokos, John P. Manis, Waleed Al-Herz, Susan S. Wallace, Raif S. Geha
Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined. Here, we have demonstrated that the pseudokinase mixed lineage kinase domain–like protein (MLKL), which plays a key role in the execution of receptor-interacting protein (RIP) kinase–dependent necroptosis, is upregulated and activated in human autoimmune hepatitis and in a murine model of inflammation-dependent hepatitis. Using genetic and pharmacologic approaches, we determined that hepatocellular necrosis in experimental hepatitis is driven by an MLKL-dependent pathway that occurs independently of RIPK3. Moreover, we have provided evidence that the cytotoxic activity of the proinflammatory cytokine IFN-γ in hepatic inflammation is strongly connected to induction of MLKL expression via activation of the transcription factor STAT1. In summary, our results reveal a pathway for MLKL-dependent programmed necrosis that is executed in the absence of RIPK3 and potentially drives the pathogenesis of severe liver diseases.
Claudia Günther, Gui-Wei He, Andreas E. Kremer, James M. Murphy, Emma J. Petrie, Kerstin Amann, Peter Vandenabeele, Andreas Linkermann, Christopher Poremba, Ulrike Schleicher, Christin Dewitz, Stefan Krautwald, Markus F. Neurath, Christoph Becker, Stefan Wirtz
Patients with mutations in
Tineke Cantaert, Jean-Nicolas Schickel, Jason M. Bannock, Yen-Shing Ng, Christopher Massad, Fabien R. Delmotte, Natsuko Yamakawa, Salome Glauzy, Nicolas Chamberlain, Tuure Kinnunen, Laurence Menard, Aubert Lavoie, Jolan E. Walter, Luigi D. Notarangelo, Julie Bruneau, Waleed Al-Herz, Sara Sebnem Kilic, Hans D. Ochs, Charlotte Cunningham-Rundles, Mirjam van der Burg, Taco W. Kuijpers, Sven Kracker, Hideo Kaneko, Yujin Sekinaka, Shigeaki Nonoyama, Anne Durandy, Eric Meffre
Studies of the genetic factors associated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these factors interact and through which tolerance pathways they operate generally remain to be defined. One key checkpoint occurs through the activity of the autoimmune regulator
Irina Proekt, Corey N. Miller, Marion Jeanne, Kayla J. Fasano, James J. Moon, Clifford A. Lowell, Douglas B. Gould, Mark S. Anderson, Anthony L. DeFranco
Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder predominantly caused by gain-of-function mutations in the protein tyrosine phosphatase SH2 domain–containing PTP (SHP2), have been shown to develop SLE, suggesting a functional correlation between phosphatase activity and systemic autoimmunity. To test this directly, we measured SHP2 activity in spleen lysates isolated from lupus-prone MRL/
Jianxun Wang, Masayuki Mizui, Li-Fan Zeng, Roderick Bronson, Michele Finnell, Cox Terhorst, Vasileios C. Kyttaris, George C. Tsokos, Zhong-Yin Zhang, Maria I. Kontaridis
Multiple sclerosis (MS) is an inflammatory disease of the CNS that is characterized by BBB dysfunction and has a much higher incidence in females. Compared with other strains of mice, EAE in the SJL mouse strain models multiple features of MS, including an enhanced sensitivity of female mice to disease; however, the molecular mechanisms that underlie the sex- and strain-dependent differences in disease susceptibility have not been described. We identified sphingosine-1-phosphate receptor 2 (S1PR2) as a sex- and strain-specific, disease-modifying molecule that regulates BBB permeability by destabilizing adherens junctions. S1PR2 expression was increased in disease-susceptible regions of the CNS of both female SJL EAE mice and female patients with MS compared with their male counterparts. Pharmacological blockade or lack of S1PR2 signaling decreased EAE disease severity as the result of enhanced endothelial barrier function. Enhanced S1PR2 signaling in an in vitro BBB model altered adherens junction formation via activation of Rho/ROCK, CDC42, and caveolin endocytosis-dependent pathways, resulting in loss of apicobasal polarity and relocation of abluminal CXCL12 to vessel lumina. Furthermore, S1PR2-dependent BBB disruption and CXCL12 relocation were observed in vivo. These results identify a link between S1PR2 signaling and BBB polarity and implicate S1PR2 in sex-specific patterns of disease during CNS autoimmunity.
Lillian Cruz-Orengo, Brian P. Daniels, Denise Dorsey, Sarah Alison Basak, José G. Grajales-Reyes, Erin E. McCandless, Laura Piccio, Robert E. Schmidt, Anne H. Cross, Seth D. Crosby, Robyn S. Klein
Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE) have multiple defects in lymphocyte signaling and function that contribute to disease pathogenesis. Such defects could be attributed to alterations in metabolic processes, including abnormal control of lipid biosynthesis pathways. Here, we reveal that CD4+ T cells from SLE patients displayed an altered profile of lipid raft–associated glycosphingolipids (GSLs) compared with that of healthy controls. In particular, lactosylceramide, globotriaosylceramide (Gb3), and monosialotetrahexosylganglioside (GM1) levels were markedly increased. Elevated GSLs in SLE patients were associated with increased expression of liver X receptor β (LXRβ), a nuclear receptor that controls cellular lipid metabolism and trafficking and influences acquired immune responses. Stimulation of CD4+ T cells isolated from healthy donors with synthetic and endogenous LXR agonists promoted GSL expression, which was blocked by an LXR antagonist. Increased GSL expression in CD4+ T cells was associated with intracellular accumulation and accelerated trafficking of GSL, reminiscent of cells from patients with glycolipid storage diseases. Inhibition of GSL biosynthesis in vitro with a clinically approved inhibitor (N-butyldeoxynojirimycin) normalized GSL metabolism, corrected CD4+ T cell signaling and functional defects, and decreased anti-dsDNA antibody production by autologous B cells in SLE patients. Our data demonstrate that lipid metabolism defects contribute to SLE pathogenesis and suggest that targeting GSL biosynthesis restores T cell function in SLE.
Georgia McDonald, Shantal Deepak, Laura Miguel, Cleo J. Hall, David A. Isenberg, Anthony I. Magee, Terry Butters, Elizabeth C. Jury
Autoantibodies against cytokines, chemokines, and growth factors inhibit normal immunity and are implicated in inflammatory autoimmune disease and diseases of immune deficiency. In an effort to evaluate serum from autoimmune and immunodeficient patients for Abs against cytokines, chemokines, and growth factors in a high-throughput and unbiased manner, we constructed a multiplex protein microarray for detection of serum factor–binding Abs and used the microarray to detect autoantibody targets in SLE. We designed a nitrocellulose-surface microarray containing human cytokines, chemokines, and other circulating proteins and demonstrated that the array permitted specific detection of serum factor–binding probes. We used the arrays to detect previously described autoantibodies against cytokines in samples from individuals with autoimmune polyendocrine syndrome type 1 and chronic mycobacterial infection. Serum profiling from individuals with SLE revealed that among several targets, elevated IgG autoantibody reactivity to B cell–activating factor (BAFF) was associated with SLE compared with control samples. BAFF reactivity correlated with the severity of disease-associated features, including IFN-α–driven SLE pathology. Our results showed that serum factor protein microarrays facilitate detection of autoantibody reactivity to serum factors in human samples and that BAFF-reactive autoantibodies may be associated with an elevated inflammatory disease state within the spectrum of SLE.
Jordan V. Price, David J. Haddon, Dodge Kemmer, Guillaume Delepine, Gil Mandelbaum, Justin A. Jarrell, Rohit Gupta, Imelda Balboni, Eliza F. Chakravarty, Jeremy Sokolove, Anthony K. Shum, Mark S. Anderson, Mickie H. Cheng, William H. Robinson, Sarah K. Browne, Steven M. Holland, Emily C. Baechler, Paul J. Utz
Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction (NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) and a kinase critical for NMJ formation, MuSK; however, a proportion of MG patients are double-negative for anti-AChR and anti-MuSK antibodies. Recent studies in these subjects have identified autoantibodies against low-density lipoprotein receptor–related protein 4 (LRP4), an agrin receptor also critical for NMJ formation. LRP4 autoantibodies have not previously been implicated in MG pathogenesis. Here we demonstrate that mice immunized with the extracellular domain of LRP4 generated anti-LRP4 antibodies and exhibited MG-associated symptoms, including muscle weakness, reduced compound muscle action potentials (CMAPs), and compromised neuromuscular transmission. Additionally, fragmented and distorted NMJs were evident at both the light microscopic and electron microscopic levels. We found that anti-LRP4 sera decreased cell surface LRP4 levels, inhibited agrin-induced MuSK activation and AChR clustering, and activated complements, revealing potential pathophysiological mechanisms. To further confirm the pathogenicity of LRP4 antibodies, we transferred IgGs purified from LRP4-immunized rabbits into naive mice and found that they exhibited MG-like symptoms, including reduced CMAP and impaired neuromuscular transmission. Together, these data demonstrate that LRP4 autoantibodies induce MG and that LRP4 contributes to NMJ maintenance in adulthood.
Chengyong Shen, Yisheng Lu, Bin Zhang, Dwight Figueiredo, Jonathan Bean, Jiung Jung, Haitao Wu, Arnab Barik, Dong-Min Yin, Wen-Cheng Xiong, Lin Mei
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity. Heterozygous mutations in the gene encoding the tumor necrosis factor receptor superfamily member TACI are associated with CVID and autoimmune manifestations, whereas two mutated alleles prevent autoimmunity. To assess how the number of
Neil Romberg, Nicolas Chamberlain, David Saadoun, Maurizio Gentile, Tuure Kinnunen, Yen Shing Ng, Manmeet Virdee, Laurence Menard, Tineke Cantaert, Henner Morbach, Rima Rachid, Natalia Martinez-Pomar, Nuria Matamoros, Raif Geha, Bodo Grimbacher, Andrea Cerutti, Charlotte Cunningham-Rundles, Eric Meffre
Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. B cells have recently emerged as major contributors to disease pathogenesis, but the mechanisms responsible for the loss of B cell tolerance in patients with MS are largely unknown. In healthy individuals, developing autoreactive B cells are removed from the repertoire at 2 tolerance checkpoints during early B cell development. Both of these central and peripheral B cell tolerance checkpoints are defective in patients with rheumatoid arthritis (RA) and type 1 diabetes (T1D). Here, we found that only the peripheral, but not the central, B cell tolerance checkpoint is defective in patients with MS. We show that this specific defect is accompanied by increased activation and homeostatic proliferation of mature naive B cells. Interestingly, all of these MS features parallel defects observed in FOXP3-deficient IPEX patients, who harbor nonfunctional Tregs. We demonstrate that in contrast to patients with RA or T1D, bone marrow central B cell selection in MS appears normal in most patients. In contrast, patients with MS suffer from a specific peripheral B cell tolerance defect that is potentially attributable to impaired Treg function and that leads to the accumulation of autoreactive B cell clones in their blood.
Tuure Kinnunen, Nicolas Chamberlain, Henner Morbach, Tineke Cantaert, Megan Lynch, Paula Preston-Hurlburt, Kevan C. Herold, David A. Hafler, Kevin C. O'Connor, Eric Meffre
Multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus, are associated with an allelic variant of protein tyrosine phosphatase nonreceptor 22 (
Xuezhi Dai, Richard G. James, Tania Habib, Swati Singh, Shaun Jackson, Socheath Khim, Randall T. Moon, Denny Liggitt, Alejandro Wolf-Yadlin, Jane H. Buckner, David J. Rawlings
The ability to selectively inactivate immune cells with immunosuppressants is a much sought-after modality for the treatment of systemic lupus erythematosus and autoimmunity in general. Here, we designed and tested a novel nanogel drug delivery vehicle for the immunosuppressant mycophenolic acid (MPA). Treatment with MPA-loaded nanogels increased the median survival time (MST) of lupus-prone NZB/W F1 mice by 3 months with prophylactic use (MST was 50 weeks versus 38 weeks without treatment), and by 2 months when administered after the development of severe renal damage (MST after proteinuria onset was 12.5 weeks versus 4 weeks without treatment). Equivalent and greater doses of MPA administered in buffer were not efficacious. Nanogels had enhanced biodistribution to organs and association with immune cells. CD4-targeted nanogels yielded similar therapeutic results compared with nontargeted formulations, with protection from glomerulonephritis and decreases in IFN-γ–positive CD4 T cells. DCs that internalized nanogels helped mediate immunosuppression, as they had reduced production of inflammatory cytokines such as IFN-γ and IL-12. Our results demonstrate efficacy of nanogel-based lupus therapy and implicate a mechanism by which immunosuppression is enhanced, in part, by the targeting of antigen-presenting cells.
Michael Look, Eric Stern, Qin A. Wang, Leah D. DiPlacido, Michael Kashgarian, Joe Craft, Tarek M. Fahmy
Mice with a DC-specific deletion of the transcriptional repressor B lymphocyte–induced maturation protein-1 (
Sun Jung Kim, Peter K. Gregersen, Betty Diamond
Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of damage to the axons and soma of neurons. Here, we show that dendritic impairment is also involved in these diseases. Deimination, a posttranslational modification, was reduced in the retinal ganglion cell layer of MS patients and in a transgenic mouse model of MS (ND4 mice). Reduced deimination accompanied a decrease in inner retinal function in ND4 mice, indicating loss of vision. Local restoration of deimination dramatically improved retinal function and elongation of neurites in isolated neurons. Further, neurite length was decreased by downregulation of deimination or siRNA knockdown of the export-binding protein REF, a primary target for deimination in these cells. REF localized to dendrites and bound selective mRNAs and translation machinery to promote protein synthesis. Thus, protein deimination and dendritic outgrowth play key roles in visual function and may be a general feature of demyelinating diseases.
Mabel Enriquez-Algeciras, Di Ding, Fabrizio G. Mastronardi, Robert E. Marc, Vittorio Porciatti, Sanjoy K. Bhattacharya
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It's been a hell of a ride for the boys in Motley Crue. Although the band said farewell with 3 fantastic shows at LA's Staples Center on the last days of 2015 - the ride is not over yet.
Right after the band's final tour, the four members continue to work hard on their endless quest to conquer the world. The most exciting news coming from the Crue is the production of the band's biopic - 'The Dirt'. The movie, based on their crazy autobiography, will reach theatres next year.
According to singer, Vince Neil, in the Las Vegas Magazine: "Making music and making movies is two different things. We're involved in it, but, we just got a new script about three or four months ago, the rewrite of the old script, and it's way, way better. It's such a great script. This movie should be out in the summer of 2016. It does stay pretty close to The Dirt, so if you've read The Dirt, it's really something to look forward to."
Besides the movie production, Neil keeps busy all the time. According to TMZ, The singer signed up for a new season of the reality TV show, 'Celebrity Apprentice', this time hosted by Arnold Schwarzenegger instead of Donald Trump. The show will air on NBC, September 2016.
But what takes up most of Neil's time is the work on his new solo album. "I'll say that we're recording some stuff for a new record this year," He Told The Michigan City News-Dispatch. "Some of the things we are working on will be in that same vein. The music is exciting. It's good, fun, nasty, raw energy and good songs. That's what is so important — good, fun songs. I mean, who wouldn't want to go out and not have a good time? Not me. So I'm thankful to be playing everywhere I am."
And what about Nikki Sixx? You got to hand it to this master mind of a bassist rocking non stop. Sixx keeps touring the world with his band, 'Sixx:A.M.'. They will hit the US in April, playing lots of festivals in Europe by June and then Canada in July. You can follow all dates and details on the band's website. In between, Sixx still finds the time to host his great radio show, 'Sixx Sense', together with co-host Jenn. You can listen to the show on iHeartRadio.
Writer(s): Nikki Sixx, Tommy Lee
Mötley Crüe - Home Sweet Home
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Writer(s): Nikki Sixx, Tommy Lee
Mick Mars also keeps playing music. The guitarist is busy in the studio with former Motley Crue singer, John Corabi. "What a great great time I'm havin creating new, fresh, greasy LOUD ASS, slamming music", wrote Mars on his Facebook page, posting a picture of Corabi and him working together.
And Tommy? Mr. Tommy Lee is having the time of his life, as always. Following up on his Twitter and Instagram profiles, the drummer is having fun working on his electronic music, traveling the world and getting ready for the Superbowl. Life has never been better.


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by La Mart
Order now to get it by: Saturday June 10 - Monday June 12
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Made from heavy duty clear plastic with netting.its a overall protection for your hairstyle. It's a one size fits all.


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VIDEO: Homeless In The Inland Empire
So I was browsing the Internet earlier today and I came across this video shot in downtown Riverside. This video really speaks out for all the homeless veterans, patients, and of course alcoholics and substance abuse adults who have been living on these streets since their teenage years. Touching and some surprising stories. Thanks to the person who shot and edited this video for an amazing job!


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No5 Chambers barrister Paul Marshall recently joined Slaughter & May's Ben Kingsley and Federico Busatta of Gianni Origoni, Grippo, Capelli & Partners to moderate IBC Legal's Global Legal Compliance Forum on anti-money laundering and investigations.
IBC Legal's Global Compliance and Ethics Forum addresses the real issues and challenges currently faced. The event has been created from discussions with compliance professionals from all industry sectors and from organisations across the spectrum. The event was interactive and focused on an honest, real-life approach.


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You're skeptical because you're visiting the website on my business card and you don't see a portfolio. I'll make it even worse: A few months ago, I made the decision to quit my stable full-time job. I didn't have another job lined up, and I wasn't even looking. And I didn't care.
What a nutcase, you're thinking.
Yeah, it was a crazy move–the best crazy move I ever made. Because I don't have a job to go to–I make my job. Every day that I wake up, I have to create a reason why someone would want to give me a paycheck. And people do. This life has given my heart a new pitter patter, because it means I'm always creating. Creating keeps me alive.
I'm getting to the point, so stay with me.
The past 4 months have been some of the busiest and the most stressful that I've had. I started a business, quit my job, got married, moved, spent 3 weeks in India, and found myself without 2 strong (or at least I had thought strong) friendships that I had expected to last for a small lifetime. Along with a few other things too. I didn't have time to create a website, and I was starting to kick myself. But when I finally got some time I realized that I don't need a full-blown website, at least not yet. I'm busy enough.
How can I be so busy? I don't have an online portfolio. There's no way people are hiring me.
The thing is, a lot of the work I've done is confidential. Increasingly now, I work with clients who prefer to remain confidential, or who only have confidential projects for me. I can't display any of that work, so a portfolio would look empty and odd. But I'm busy enough, with room for more.
There's an upside to keeping a low profile, it seems. And because it's fun, I'm continuing to "blog," which seems to have become a verb from the last time I tweeted. When I have enough public work, I may start a website.
Till then, you can always email me and find out more about how my writing can help you, your company, or your amazing cause that I would totally fall in love with, and work for free on. (Yep, I said work for free. But you have to be really amazing.)
Hope to see you on the inside of creative.


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If this program is free, than what's the catch?
3 Replies
Feb 16, 2007 at 9:23 UTC
I see you started a new thread for this.
Directly from their website:
And, Spiceworks is really free. No trials. No time or device limits. Simply free. All thanks to sponsorships by top technology vendors.
Also, check out the ComputerWorld article also linked from their website at:
It's all advertising supported. It's not an entirely new business model. Spyware companies have been doing that for years -- NOT to equate Spiceworks with spyware! But when you're talking about advertising as a source of revenue and you're looking at the SMB market, there's a ton of us out there. Spiceworks has a great model and business case for going this route.
Apr 18, 2010 at 6:11 UTC
Niagara Technology Group (NTG) is an IT service provider.
It ad-drive. Television is free, paid for by ads. What's the catch?


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Home of the vibrant Miami Beach, the "city within city", Miami is an extraordinary place, built on holiday, hype and a myriad things to do by boat. The weather seldom dips below balmy, beaches are gorgeous, and people are simply beautiful. Hop aboard your yacht charter in Miami and go snorkeling, join the non-stop party at the sandbar, and end your day with a dockside dining experience with a breathtaking view.More about Miami, FL


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For leg spinner Amit Mishra, Thursday was a busy day. Released by the Indian team management from the squad for the second test match in Vishakapatnam, Mishra celebrated his 34th birthday -- first by picking three wickets in the second innings in his Ranji team Haryana's match against Goa in Ghaziabad. Then he made a quick dash to Badarpur border, New Delhi, to spend quality time with the inmates of Guru Vishram Vridh Ashram.
Mishra, cut the cake with senior citizens, many of whom were lost in their own little world. Majority of the inmates in the old age home suffered from Alzheimer and were in critical condition.
A dinner was specially arranged by Mishra before he headed for Mohali to join the Indian cricket team for the third test starting from Saturday against the visiting England team.
Speaking on the occasion, Amit Mishra said, "I feel very happy spending time with people who are in need of help. It is painful to watch them being abandoned by their own children at a time when they are in need of utmost care. I feel blessed to be spending quality time with them and celebrating my birthday."
The old age home is a ray of hope for the helpless elderly people suffering from various diseases and disorders, including those who are mentally and physically ill, apart from the destitute elderly people who are admitted by Delhi police as well as government hospitals and social workers.
Currently, the ashram has 100 beds and provides free food for all the inmates. They are provided with 24 hour medical aid with the presence of a doctor and nurse around the clock.


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Don't forget to register for the Second Shot offer and take your first exam by May 31. Then if you fail, you have until the end of June to retake that same exam for free.
Just heard this from Todd about bootcamps this month in 10 cities in Canada: "…Canadian IT Pro event…Windows 2008 Certification. At their sessions across the country, they are giving away one free MS Press book (choice of 70-640,70-642,70-643 or 70-299) and an exam voucher." Get the scoop.
If you're in Chicago, Illinois, you can save 10% on any of ChicagoCon's bootcamps (May 12-18, 2008…additional five-day boot camps (ISA Server 2006, CISSP, CEH, Forensics, Advanced Hacking, Net+/Sec+). E-mail Collin Walsh and let him know you're an MCP to get the discount.
Speaking of Illinois, I'm excited because I'm taking the train to Portland, Oregon this evening for the Official Bridge Club National Convention*. I am representing the Seattle Chapter.** I love taking the train. The Cascades line train from Seattle to PDX is one of the best, too–it is a beautiful ride along the water, then through some fields, with views of mountains, and, when one feels racy, there's a Bud Light to be had in the dining car. Then you arrive at Portland's rad, old-school station with clock tower and wood seating and marble walls and Go by Train! sign.
I like it so much!
- Famous MCT Ron Beekelaar happened to be on my same flight home from Heathrow. That was fun.
- Look, it is Niall Merrigan, talking about his company's certification program.
- Mark Shea, a Microsoft Learning guy, is studying for MCTS: Sharepoint Configuration, if you want to follow along…
* There are not very many members of the OBC. All but two of them live in Portland, Oregon.
** In fact, I am the sole member of the Seattle Chapter.


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Your Buick dealership isn't the only place to buy trusted parts to repair your Apollo. Make no mistake, you didn't buy your Apollo unless you knew that you wanted efficiency and American style both rolled up into one car, truck, or SUV. It's not all the time that you realize that you have to buy a replacement Spark Plug to repair your vehicle. The vehicle in your driveway is head and shoulders above the rest compared to all the other cars, trucks, and SUVs currently being driven today.
There are ignition parts in your engine so small that they aren't considered when there's a performance problem. The job of detonating the air/fuel mixture in the combustion chambers in the engine is your Buick Apollo spark plug. Basic spark plugs use a copper electrode, while performance spark plugs use platinum or iridium on all current models. When one of the spark plugs does not fire when it should, the engine in your Buick Apollo will not turn as hard; reducing power and gas mileage while increasing harmful emissions.
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Xperia™ ray offer
1. General Terms and Conditions for the Xperia™ray 12-month magazine subscription promotion.
- 1.1 Offer open to residents of the UK, Channel Islands and the Isle of Man except employees and their immediate families of the Promoters, their subsidiaries or affiliated companies, or anyone professionally connected to the promotion.
- 1.2 Offer applies to consumers purchasing a Sony Ericsson Xperia™ ray handset on Pay Monthly or Pay As You Go in any UK O2 channel (store, online, telesales, retention and upgrades) from 30th September 2011 to 27th October 2011 ("the Promotional Period") who will be eligible to claim a complimentary 12-month magazine subscription to one of the following titles: Men's Health, Company, GQ or Glamour.
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- 1.10 The Promoters' decision is final and no correspondence will be entered into. This promotion is governed by English law.
- 1.11 By participating in this promotion, entrants agree to be bound by the terms and conditions.
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- 2.1 After purchase, all Sony Ericsson Xperia™ ray handsets will be distributed with a promotional leaflet directing you to sonyericsson.com/o2freemag. To enter the promotion, you will be required to submit personal details and validate your purchase by entering your phone's IMEI number and unique promotional code from the promotional leaflet.
2.2 The IMEI number is located on the side of your Xperia™ ray handset box. Alternatively you can do the following:
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The Promoters: Sony Ericsson Mobile Communications AB of Nya Vattentornet, SE-22188 Lund, Sweden.


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Posted by anonymous
she doesnt call you back, she doesnt keep you informed, she isnt very considerate, she says things before she even knows, she has been rude, and in my case isnt allowing me to a trail shes only stated an excuse why she wont, theyll add more charges if we take it to trial, i dont have a defense. she is very unprofessional considering her job title. i would not EVER recommend her and i am hoping i can get difference defense.


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Andre Fischer <awf....@gmail.com>
|Re: [VOTE][DISCUSS]: Release Apache OpenOffice 3.4.1 (incubating)
|Sat, 04 Aug 2012 14:38:17 GMT
On 02.08.2012 13:36, Rob Weir wrote: > On Thu, Aug 2, 2012 at 2:42 AM, Andre Fischer <email@example.com> wrote: >> On 01.08.2012 14:56, Rob Weir wrote: >>> On Wed, Aug 1, 2012 at 3:37 AM, Andre Fischer <email@example.com> wrote: >>>> Hi Joe, >>>> >>>> >>>> On 30.07.2012 19:19, Joe Schaefer wrote: >>>>> Please be sure to decouple the source builds >>>>> from downloading artifacts directly from svn.apache.org. >>>>> I trust that has been done by now as what 3.4.0 >>>>> did constitutes an infra policy violation, besides >>>>> complicating eventual graduation moves of your svn tree. >>>> >>>> Good point. Thanks for reminding me. I have created bug 120425 [1] for >>>> copying the category-A tarballs to an external server, apache-extras. I >>>> am >>>> doing this on trunk because, as I hope you will agree, a micro release is >>>> not the right place for such a change. >>>> >>> The issue is our svn tree will move after graduation, but there is no >>> redirection like there is with the website. >>> >>> So instead of being in https://svn.apache.org/repos/asf/incubator/ooo/ >>> we will be in https://svn.apache.org/repos/asf/openoffice or something >>> like that. >>> >>> So those who have downloaded the AOO 3.4.1. source tarball will find >>> that their script breaks. >> >> Not necessarily. There are simple technical solutions for this problem: >> >> - Copy, don't move, at least the ext_sources/ tree of the repository. The >> incubator copy can be deleted on our next release. >> >> - Use an SVN link to keep the old incubator URL for ext_sources/ alive until >> the next release. >> >> - Wait with the transition of the repository until the next release. >> > I don't see how this solves the Infrastructure policy issue. If I > understand it correctly, it is not merely about where in SVN we store > these dependencies. The issue is that we have our build script hitting > SVN at all. Joe could confirm that. I just wanted to point out that if we find a political consensus then we also have a technical solution for the problem. Besides, I don´t think that the downloading of the tarballs by the build script is a big problem. Most tarballs are checked out together with the rest of the source code from SVN. The build script basically makes sure that none of the tarballs has been deleted in the meantime. The exception, of course, are builds from the source release, that does not contain any tarballs. But with the few downloads of the source release I can not see a problem here either. Last, but not least, bug 120425 is already fixed. All tarballs of the branch and most of trunk are now downloaded - from their original download servers (where I have found them) - first fallback is apache-exrtras - second fallback (will be removed shortly) is the SVN repository. -Andre > What if we bundled the cat-a dependencies in the source tarball? > Would that work? Same net downloads, but the bandwidth then comes > from the mirror network. > >> Independently from this problem, it might be a good idea to have a >> transition phase after graduation during which both URLs are valid. >> >> -Andre >> >> >>> -Rob >>> >>> >>> >>>> Andre >>>> >>>> [1] https://issues.apache.org/ooo/show_bug.cgi?id=120425 >>>> >>>> >>>>> Thanks. >>>>> >>>>> >>>>> >>>>> >>>>>> ________________________________ >>>>>> From: Rob Weir <email@example.com> >>>>>> To: email@example.com >>>>>> Sent: Monday, July 30, 2012 1:17 PM >>>>>> Subject: Re: [VOTE][DISCUSS]: Release Apache OpenOffice 3.4.1 >>>>>> (incubating) >>>>>> >>>>>> I plan on testing the Release Candidate 3.4.1 on WinXP/SP3, and >>>>>> verifying installing over OOo 3.3.0, AOO 3.4.0 and LO 3.5.5. >>>>>> >>>>>> It would be good if others could mention what they intend to look at, >>>>>> so we can avoid unnecessary duplication of effort. >>>>>> >>>>>> Also, is the RAT scan results online anywhere? It would be good to >>>>>> review that. >>>>>> >>>>>> Also, if anyone has handy a diff of the NOTICE and LICENSE files from >>>>>> 3.4.0 to 3.4.1, that would be good to review as well. >>>>>> >>>>>> -Rob >>>>>> >>>>>> >>>>>>
|View raw message


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Popular property highlights
Novotel Aix en Provence Beaumanoir Les 3 Sautets places you within 2 miles (3 km) of popular sights like Place des Precheurs and Cours Mirabeau. This 102-room, 4-star hotel has a restaurant along with conveniences like an outdoor pool and free in-room WiFi. Also nearby are Saint-Sauveur Cathedral and Granet Museum.
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Novotel Aix en Provence Beaumanoir Les 3 Sautets's 102 soundproofed rooms provide sofa beds, refrigerators, and coffee makers. Guests can expect wired Internet, free WiFi, and flat-screen TVs with satellite channels. Bathrooms have hair dryers and free toiletries. Other standard amenities include free bottled water, safes, and phones.
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Property features
- Free WiFi in rooms and public areas
- Free parking
- Onsite dining
- Outdoor pool
HighlightsInformation missing or incorrect? Tell us!Opens in a new window
Novotel Aix en Provence Beaumanoir Les 3 Sautets
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary wireless Internet access. 6 meeting rooms are available. This family-friendly hotel also offers an outdoor pool, a terrace, and barbecue grills. Complimentary self parking is available on site.
Novotel Aix en Provence Beaumanoir Les 3 Sautets is a smoke-free property.
- Babysitting or childcare (surcharge)
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Family Friendly Amenities
- Family Hotel
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- Soundproofed rooms
- Babysitting or childcare (surcharge)
- Playground on site
- Sofa bed
- Refrigerator
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi , Wired internet access ( EUR 10 per night )
Available in some public areas: Free WiFi
Free self parking
Room Amenities
Novotel Aix en Provence Beaumanoir Les 3 Sautets offers 102 air-conditioned accommodations with safes and complimentary bottled water. These individually decorated accommodations include sofa beds. Flat-screen televisions come with satellite channels. Refrigerators and coffee/tea makers are provided. Bathrooms include bathtubs, complimentary toiletries, and hair dryers.
Guests can surf the web using the complimentary wireless Internet access. Business-friendly amenities include desks and phones. Housekeeping is offered daily and irons/ironing boards can be requested.
- Air conditioning
- Soundproofed rooms
- In-room climate control (air conditioning)
- Phone
- Refrigerator
- Coffee/tea maker
- Free bottled water
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Bathtub only
- Satellite TV service
- Desk
- In-room safe
- Iron/ironing board (on request)
- Sofa bed
- Blackout drapes/curtains
- Flat-panel TV
- Free WiFi
- Wired high-speed Internet access (surcharge)
- Room service (limited hours)
- Individually decorated
- Free cribs/infant beds
Where to Eat
Novotel cafe - Overlooking the pool and garden, this restaurant serves breakfast, lunch, dinner, and light fare. A children's menu is available.
Room service (during limited hours) is available.
Breakfast is available for a surcharge each morning.
Nearby Things to Do
Recreational amenities at the hotel include an outdoor pool.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Playground on site
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- Roll-in shower
- In-room accessibility
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Free cribs (infant beds)!
- Pets allowed for an extra charge of EUR 9 per pet, per stay
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
- A tax is imposed by the city: EUR 1.6 per person, per night. This tax does not apply to children under 12 years of age.
Optional extras
- Breakfast fee: EUR 16.50 per person (approximately)
- Fee for in-room wired Internet: EUR 10 per night (rates may vary)
- Pet fee: EUR 9 per pet, per stay
Hotel Name
- Beaumanoir
- Novotel Aix Beaumanoir 3 Sautets
- Novotel Aix Beaumanoir 3 Sautets Hotel
- Novotel Aix Beaumanoir 3 Sautets Hotel Provence en
- Novotel Aix en Provence Beaumanoir 3 Sautets
- Novotel Beaumanoir
- Novotel Aix en Provence Beaumanoir 3 Sautets Hotel
- Novotel Beaumanoir 3 Sautets Hotel
- Novotel Beaumanoir 3 Sautets
- Aix-En-Provence Novotel
National Rating
This property has received its official star rating from the French Tourism Development Agency, ATOUT France.


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ED Magedson – Founder
Ripoff Report
Retama Ranch Apartments12900 East Loop 1604 North Cibolo, Texas U.S.A.
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This report was posted on Ripoff Report on 11/28/2007 11:46 AM and is a permanent record located here: http://www.ripoffreport.com/reports/retama-ranch-apartments/cibolo-texas-78108/retama-ranch-apartments-apartment-stole-stolen-cibolo-texas-287398. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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It's easy to leave but harder to stay. This is the part 2 series of Marriage: Is it Really an Outrageous Commitment. Last week we talk about the Vow and Commitment and the meaning, now let's talk about how we keep the vow, commitment and not break it. We will have a special guest on the show, Dr. Michael Woods. He is a Marriage, Family Therapist and a Professor at California State University of Sacramento. He has his own private practice for the past 12 years. He will be answering many of the questions we have about marriage therapy and how it works and much much more. So come prepared to write, listen and have an open mind. This is a show you don't want to miss.
Come join the conversation.
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The song was released sometime back and is breaking the internet right now
The makers of Katrina Kaif and Sidharth Malhotra's Baar Baar Dekho, released their first song, Kala Chasma sometime back and the song has been on loop since then. This song is the latest one to join the list of songs which are remakes of popular albums in the past.
Sorry Sidharth, nothing against you but we just couldn't take our eyes off Katrina who has made us sweat with her hotness. This seems to be the season of abs as Katrina is seen flaunting her killer abs after Parineeti showed off her abs in Jaaneman Aah in Dishoom.
Now since we know how difficult it was for us to check out her best moves from the song considering all are splendid, we thought of making it easier for you. We bring to you five of the killer moves by Katrina in the song where her abs might just kill you, so beware.
#Where she outshines Sidharth
Katrina, you can't make it so difficult for Siddharth. This killer move by her with Sid makes us wonder if the actor preferred having this as a solo number for Katrina.
#Where you wonder if Geometry has any better curves!
This move reminded us of Deepika Padukone in 'Lovely' from Happy New Year. She starts the song with grooving and later flaunts her abs whereas Katrina has better moves to concentrate and flaunt.
#Where she made us conscious
Ouch! She just made us wonder if we should exist in this world. After watching this particular move, we wanna ask Katrina, what's her waist size?
# When she prefers going solo
And she goes solo. Probably even the choreographers realised, it's better to make her do it solo to increase the oomph factor in the song. Katrina just tell us, how many days did you starve for this killer look.
#When she makes a basic step look HOT
This is the classic move of this song. Now actually we don't care for the moves any longer as long as her abs are visible. Way to go girl.
Check them out and if you faint, blame it on Katrina!
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Afternoon audio analysis 07.04.2015:
The market is talking about Greece again. What can happen in the upcoming days, and when will Athens be financed again? Russian rouble is unusualy strong. Is there a chance for further enforcement?
Marcin Lipka, analityk Cinkciarz.pl
This audio analysis is not a recommendation within the meaning of Regulation of the Minister of Finance of 19 October 2005. It has been prepared for information purposes only and should not serve as a basis for making any investment decisions. Neither the author nor the publisher can be held liable for investment decisions made on the basis of information contained in this commentary. Copying or duplicating this report without the written permission from Cinkciarz.pl Sp. z o.o is prohibited.
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Hilton Ponce Golf & Casino Resort
Select your stay dates to check availability at Hilton Ponce Golf & Casino Resort
Hilton Ponce Golf & Casino Resort
About the Hotel
Property Location
When you stay at Hilton Ponce Golf & Casino Resort in Ponce, you'll be on the beach and close to La Guancha and Parque de Bombas. This 4-star resort is within close proximity of School of Fine Arts and Pontifical Catholic University of Puerto Rico.
Make yourself at home in one of the 255 air-conditioned rooms featuring refrigerators and LCD televisions. Rooms have private balconies or patios. Wired and wireless Internet access is complimentary, while MP3 docking stations and cable programming provide entertainment. Private bathrooms with showers feature designer toiletries and hair dryers.
Practice your swing on the golf course or dip into one of the 2 outdoor swimming pools or 2 spa tubs. Additional features at this resort include complimentary wireless Internet access, concierge services, and an arcade/game room.
Enjoy a meal at one of the resort's dining establishments, which include 4 restaurants and a coffee shop/café. From your room, you can also access room service (during limited hours). Relax with a refreshing drink from a poolside bar or one of the 3 bars/lounges. Buffet breakfasts are available daily for a fee.
Business, Other Amenities
Featured amenities include complimentary high-speed (wired) Internet access, a business center, and express check-in. Planning an event in Ponce? This resort has 26910 square feet (2500 square meters) of space consisting of conference space and meeting rooms. A roundtrip airport shuttle is provided for a surcharge (available on request), and self parking (subject to charges) is available onsite.
Hotel Facilities
- Express check-in
- Outdoor tennis courts - 4
- Arcade/game room
- Number of spa tubs - 2
- Year Built 1992
- Snack bar/deli
- 24-hour front desk
- ATM/banking
- Garden
- Golf course on site
- Children's pool
- Spa tub
- Dry cleaning/laundry service
- Sauna
- Porter/bellhop
- Waterslide
- Concierge services
- Conference space size (feet) - 26910
- Breakfast available (surcharge)
- Beach sun loungers
- Conference space size (meters) - 2500
- Number of outdoor pools - 2
- Coffee shop or café
- Accessible bathroom
- Gift shops or newsstand
- Multilingual staff
- Free wired high-speed Internet
- Billiards or pool table
- Total number of rooms - 255
- Beach umbrellas
- Free water park access
- Poolside bar
- Luggage storage
- Shopping on site
- Elevator/lift
- Free newspapers in lobby
- Self parking (surcharge)
- Water park
- Business center
- Laundry facilities
- Number of meeting rooms - 18
- Valet parking (surcharge)
- Conference space
- Number of floors - 5
- Smoke-free property
- Wedding services
- Roll-in shower
- Fitness facilities
- Tennis on site
- Number of bars/lounges - 3
- Casino
- Airport transportation (surcharge)
- Number of restaurants - 4
- Meeting rooms 18
- Express check-out
- Pool umbrellas
- Free WiFi
- In-room accessibility
- Beach towels
- Number of buildings/towers - 3
Room Facilities
- Cable TV service
- Free wired high-speed Internet
- In-room climate control (air conditioning)
- Daily housekeeping
- MP3 docking station
- In-room safe (laptop compatible)
- Free toiletries
- Phone
- Designer toiletries
- Free WiFi
- Air conditioning
- Desk
- Private bathroom
- Refrigerator
- Balcony or patio
- Access via exterior corridors
- Hair dryer
- Iron/ironing board
- Free cribs/infant beds
- Room service (limited hours)
- Ceiling fan
- Shower only
- Blackout drapes/curtains
- Coffee/tea maker
Hotel Policy
Know Before You Go
- This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details 24 hours prior to arrival, using the contact information on the booking confirmation.
- Reservations are required for massage services. Reservations can be made by contacting the resort prior to arrival, using the contact information on the booking confirmation.
- Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.
- Only registered guests are allowed in the guestrooms.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Fee for buffet breakfast: USD $22 for adults and USD $11 from 6-12 years old for children (approximately)
- Self parking fee: USD $10 per day (in/out privileges)
- Valet parking fee: USD $18 per day (in/out privileges)
- Early check-in fee: USD $75
- Late check-out fee: USD $75
- In-room microwave fee: USD $15 per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Mandatory Fees and Taxes
You'll be asked to pay the following charges at the property:
- Resort fee: 14 percent of room rate
- Pool access
- Beach access
- Beach loungers
- Beach towels
- Fitness center access
- Shuttle service
- Internet access
- In-room coffee
We have included all charges provided to us by the property. However, charges can vary, for example, based on length of stay or the room you book.Show all hotel policy Show less hotel policy


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Fade + Restylane Q&A
Does hydroquinone usp 4% fade discoloration of under eye restylane?
How long does hydroquinone usp 4% skin bleaching cream fade discoloration from under eye restylane? READ MORE
My results after a syringe of Restylane are fading fast, is this normal? (photos)
Had a full syringe of Restylane injected into tear troughs, nasial folds & marionette lines. Restylane tear trough results fading at 3 month mark. READ MORE
Day 13/14 Restylane fillers on nose. Is this a bruise and will it fade soon? (photo)
It's been 13/14 days since I got restylane fillers in my nose and lips. My nose has a red/pink/brown mark above where the filler was injected (mark is... READ MORE
How to know that I have biofilm infection ?!
Am 28 yrs and Before 2 yrs i had restylene under my eyes ( i can feel the product )and at the same time i dont wanna try vitrase because am affraid to... READ MORE
After Restylane injection on chin, dark bruise, am I in danger? (photos)
This is my first time to have Restylane injected on my chin . I had it around more than 48hrs. The bruise are getting darker . But the pain is fading ... READ MORE
Drinking water and filler.
I would like to know if I drink like 100oz or more daily could make the filler (restalyne tear troughs area) fade it?or not long lasting? READ MORE
Can I get rid of the darkness caused by filler under my eyes and around my mouth? Could this be hemosiderin staining? (photos)
About 4 weeks ago I received Restylane and Restylane Silk to fill under my eyes and Juvederm and Restylane Silk to fill in marionette lines.... READ MORE


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City leaders have suggested the police chief become the temporary leader of the Wauwatosa Fire Department come January.
A letter has been submitted to the city's Police and Fire Commission by the city administrator, mayor and chairman of the Common Council's Budget and Finance and Employee Relations committees. The message to the commission is that Police Chief Barry Weber already has experience overseeing emergency services and managing emergency situations so his role could be expanded for a few months while a permanent fire chief is found.
The city will not release information on how many people have applied for the interim chief position. The Fire Department has two assistant chiefs and four deputy chiefs working under Fire Chief Dean Redman.
Redman has announced he will retire Jan. 4.
The commission will meet Wednesday at 3 p.m. at the Police Department, 1700 N. 116th St. The fire chief recruitment process and consideration of interim candidates is on the agenda.
More from News and Features
- Anodyne Coffee plans to open location in Wauwatosa Village
- Wauwatosa Meetings: Aug. 4
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- Wauwatosa News and Notes: Hands-only CPR training offered; Firefly Art Fair is Aug. 6-7
- Wauwatosa Ask Now: Why are there barriers and fencing along the North Avenue bridges over the Menomonee River?
- Mystery Photo Contest: July 28
- Wauwatosa gears up for National Night Out event, this year at the zoo
- Election 2016: Wisconsin's 4th District candidates weigh in
- Wauwatosa's Luther Manor residents share smiles through flower delivery
- Wauwatosa Police Report: July 17-23


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New Braunfels Herald Zeitung (Newspaper) - December 17, 2004, New Braunfels, Texas MIXED ADC. 781 1000571 05-16AJ5 S0UTHUF3T H.ItROPllGLIbHERo 2o£ I ANDELL Ok a MSO TX WO? 111 It i111 I I I' ^' FRIDAY, DECEMBER 17,2004 erald-Zeitung SPORTS ALL STATE Four New Braunfels players, one from Canyon are named to the AP's Class 4A all-state football teams. Page 7A FORUM LETTERS Readers sound off on downtown merchants and how CISD trustees must lead by foresight. Page 4A Serving New Braunfels and Comal County since 1852. Vol. 154, No. 28 16 pages, 2 sections B50C herald-zeitung.com I a 56825 00001 v Mostly sunny High Low 60 37 Details .... 1B DEAR ABBY 4B CLASSIFIEDS 4B COMICS 2B CROSSWORD 2B FORUM 4A OBITUARIES 3A SPORTS 7A TV GRIDS 4BCommissioners take look at tax district By Ron Maloney Staff Writer Comal County commissioners Thursday got an in-depth look at the funding scenario for a proposed hotel and convention center and appeared to like what they heard. And if Michael Coker, the former Dallas planning director who proposes the revital ization of the vacant Mission Valley Mills site into a $50 million, 200 to 300 room hotel and convention center had attended commissioners' court, he'd have liked what he heard. Commissioners listened to presentations by New Braunfels City Manager Chuck Hnto, and Coker Corp. Project Manager Richard Boyd, asked questions about the project and its l ax Increment Financing District funding scenario, and expressed support for the concept. No vote was taken because the presentation was part of the county's workshop agenda. If the city votes to establish a TIF district at its Jan. 24 city council meeting, the question See DISTRICT, Page 3A Casteel previews legislative issues By Scott Mahon Staff Writer State Rep. Carter Casteel said school finance, worker's compensation and Child Protective Services would be among the top issues facing the 79th Texas Legislature. Casteel, R-New Braunfels, gave a legislative preview Thursday at I lonors I jail to the Greater New Braunfels Chamber of Commerce Legislative Affairs Committee. "Who is going to be Texas' next governor will have an impact on the session," Casteel began. "Personally, I don't have a clue, although State Comptroller Carole Keeton Carter Casteel Strayhorn will develop a lot of issues, and I ve heard that Sen. Kay Bailey I futchison will run." The 79th Texas Legislature convenes in regular session Jan. 11,2005. Casteel, who was first elected to represent District 73 in November 2000, will begin her second term as a state legislator. District 73 includes Gillespie, Comal, Kendall and Bandera counties. Because state District Judge john Dietz of Austin ruled in September that Texas must create a new school finance See CASTEEL, Page 6A Made from scratch Recent class at The Sophienburg offered tips on how to make tamales. 2004 CHEER FUND Donations are still being accepted for the 2004 Cheer Fund. To donate— ■ Stop by the Herald-Zeitung office at 707 Landa St. between 8 a.m. and 5 p.m., Monday through Friday or mail a check made out to the New Braunfels Herald-Zeitung to Cheer Fund, New Braunfels Herald-Zeitung, 707 Landa St., New Braunfels, 78130, before Dec. 18. ■ To volunteer to deliver for the Cheer Fund - Call 625-9144, ext. 203 or show up at the Herald-Zeitung printing plant on Industrial Drive at 8 a.m. Saturday, Dec. 18. Mighty Ranger Band prepares to cheer on football team at state game Thanks to the following for their support: ■ Mr. and Mrs. Adrian Goodson ■ Carmen and John Malcolm ■ S.L. Phillips By Leigh Jones Staff Writer Andrew Motley, a senior drum major with the Mighty Ranger Band, is having a very busy week. In the middle of studying for his AP final exams, Motley has had to find time to make preparations for the band's long road trip to Dallas for Saturday's state championship football game. "It has been crazy this week," Motley said. "We've had to get sign-up lists for the charter bus es and coordinate meal stops." Motley is one of 195 band members who will make the trip to Texas Stadium. While the logistics are a nightmare, Motley said the roar of the crowd would make it all worthwhile. Bands do not always get the crowd appreciation their hard work deserves. Most people come to see the football team and do not appreciate the technically difficult routines the band performs. But last week, crowds in the Alaniodome gave the Rangers musicians a standing ovation for doing something a little different. After the instrumentalists marched into a "SV #1" formation, they began to fall down, domino style, while yelling at the top of their lungs. The straight formation connected together and turned into a cursive display, while the band members continued to play, finishing the Smithson Valley I ligh See SVHS, Page 3A SVHS 2004 POSTSEASON SCORES « SVHS 38, San Marcos 21 ■ SVHS 48, San Antonio Clark 20 ■ SVHS 51, San Benito 0 ■ SVHS 42, San Antonio-Taft 24 m SVHS 18, Houston Clear Lake 10 FAT f ridays, the Herald-Zeitung will feat Ute a different house of worship. CHRIST INTERNATIONAL TABERNACLE B Pastor: Carolyn Stovall Gilbert g Denomination: nondenominational g Attendance: Under 50 g Meeting time: 7 p.m. Thursday ■ Location: Landa Park Recreation Center, second floor, 164 Landa Park Drive ■ Phone: (830) 822-6988 ■ Worship style: nontraditional ■ Mission: Unity, love and reconciliation Christ International Tabernacle works to bring unity By Leigh Jones Staff Writer Four years ago, Carolyn Stovall Gilbert was driving through New Braunfels when she felt moved to pray for the city. As with most places she looks, Gilbert saw a need for reconciliation. "We all live in our own little worlds and cultures,'' she said. "I want to see walls broken down." Gilbert prayed for the city for two years, continuing to drive through it on Interstate 35, until she felt compelled to start a mission church. Christ International Tabernacle New Braunfels had its first meeting in June 2003, in Landa Park. During the praise service, Gilbert and the small congregation received a sign. "Three ducks walked up to us — a yellow duck, a white duck and a black duck," she said, laughing. "I took that as a strong sign of reconciliation.'' Christ International Tabernacle jumped right in to local mission work, partnering with the Parks and Recreation Department to serve the city's youths. T hey hosted basketball and dodge ball tournaments at the Landa Park recreation center, providing food for aftergame gatherings. Knowing her small congregation cannot meet ail of the city's needs, Gilbert believes strongly in collaborating with other churches in the area. Twice a month, she meets with six other pastors from New Braunfels anti die Canyon I ake area to pray for unity. "We can make progress if we work together to make our community better," she said. Alter the beginning of the year, Gilbert and her congregation are planning a concentrated evangelical push into the city's housing projects. "We are in the early stages of planting now, but we are expecting a great harvest See CHURCH, Page 6A MANDY REARY Herald-Zeitung Carolyn Stovall Gilbert, pastor of the Christ International Tabernacle, at the Landa Recreational Center, where services meet in an upstairs room. DAVID INGRAM/Herald-Zeituny As Smithson Valley High School assistant band director MarkWatley (left) supervises Ranger Band drum majors Andrew Motley, Amanda Johnson andTom Anderson prepare to load up the band's trailer with equipment for their performance in Texas Stadium at the Class 5A Division ll State Football Championship Saturday. DRUMMING UP SPIRIT Christ International Tabernacle ;
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text:
Spyro was in the arena, trying out a new type of breath that he had got when he traded an old rock at the Fountain of Life. This breath was bullet breath. It shot bullets and silvery wisps of mist at enemies.
Spyro had decided that he liked this breath a lot better than the others. The arena wood suddenly had holes in it. Spyro coughed. His dragonfly, Sparx, tutted. "Spyro. You shouldn't use coughing as an excuse to use a breath."
"I know," Spyro said in his high-pitched voice, and glided down to the ground. He hated the area being two metres in the air because he was afraid of heights. He was alright when gliding but it was when he was alone, on a platform or a cliff, that all of his troubles started to show.
"And dragons shouldn't be afraid of heights," Sparx continued, fluttering around his head. "Especially young dragons like you who the elders rely on to keep the Realms safe from Ripto."
"I know," Spyro muttered.
His claws sank into the mud and he treasured the feeling for a few seconds, until Sparx brought him back from his dream world with a rather violent stabbing attack. "It helps to keep focused, Spyro."
"I can keep focused without you stabbing me with your tail, Sparx," he whispered without taking his eyes off the ground. "I just wish my parents were here to teach me. Why did Ripto take them?"
Sparx didn't say anything because he couldn't. His eyes were too wet from tears. Dragonfly tears.
- - - - -
Hunter was shooting apples in a tree when Spyro came to visit him, a short hour after the young dragon had been testing his new breath. Hunter was a cheetah and a good friend for Spyro. Not many people had believed Spyro when he said that he had stopped Ripto from carrying out his evil plans, but Hunter had always been there for him and believed everything he said.
It was these characteristics that made Hunter such a brilliant friend.
"Hunter, can I confide in you?" Spyro asked. Hunter put down his bow and arrow to make sure he was listening to what Spyro wanted to tell him. "The thing is, both my parents are missing and I think Ripto took them away to his cave. The next thing is that I have no idea where to find the cave."
"Ripto?" Hunter spat. "Where is he? Why has he taken your parents to a cave? Why do you want to find out where the cave is?"
Spyro frowned. So much for Hunter understanding and respecting him. Hunter had no idea what he was talking about. "Same as always, Hunter. I want to defeat Ripto. And I want to find my parents."
"Ripto is far too dangerous for a young dragon like you to fight," Hunter told him. "I think you should stay where you are, or at least let your parents fight him instead. Do you understand?"
Spyro froze in his tracks.
Why was Hunter being like this? Was he perhaps replaced with a robot that Ripto had constructed?
"But all those years, you helped me," Spyro yelled. He clawed at Hunter's foot in frustration. "You helped me defeat him by showing me fighting moves, and now you tell me to stay put?"
"Yes," Hunter said.
"But Hunter, my parents can't fight him for me. They're trapped with him. I've got to save them." Spyro's tears were trickling down his face. When they touched the ground the tears turned to ice.
"You're too late," Hunter said. "They perished two days ago. Maybe if you had learned of their capture earlier, you could have saved them. There is nothing you can do. Just go home."


text:
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