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March 8, 2013
Coach Beilein | Tim Hardaway Jr. | Trey Burke
Game Notes | Game Central
ANN ARBOR, Mich. -- The University of Michigan men's basketball team will enter Sunday's (March 10) matchup with second-ranked Indiana just one win away from earning a share of the Big Ten regular-season title for the second year in a row.
In a conference which has seen at least two teams ranked in the top 10 all season and as many as six teams ranked in one week, coming out on top after a grueling 18-game conference schedule is no easy feat -- and doing it in back-to-back seasons is even more remarkable.
Sunday's matchup could prove to be extra special if Michigan secures the win and a share of the conference title, but it will be memorable regardless for the Wolverines' five seniors, who will run down the tunnel for the last time and be honored prior to tipoff.
In addition to Michigan's five seniors -- Eso Akunne, Josh Bartelstein, Blake McLimans, Corey Person and Matt Vogrich -- the program will also honor members of Team Maize, as well as its senior managers.
Senior Day will be bittersweet for three managers who have been a part of the program since their freshman year at Michigan. Seniors Danny Ackerman, Matt Sawyer and Brandon Verlinden each earned their roles as managers soon after stepping foot on campus for the first time. Three complete strangers, who migrated to Ann Arbor from three different states, soon developed a strong friendship and gained the trust of the players and staff.
After two years of hard work and dedication to the program, the three gained more responsibility and began traveling to all road games with the team. They have seen the highest of highs and lowest of lows throughout their four years and are hoping their final game at Crisler Center is a memorable one and ends with Michigan cutting down the net for the first time in their careers.
The Wolverines held a media roundtable on Friday (March 8) prior hosting Indiana on Sunday at 4 p.m. inside Crisler Center. Fans are encouraged to wear maize-colored clothing for the official "Maize Out" and arrive early for the senior recognition ceremony.
In addition to Coach Beilein, Trey Burke and Tim Hardaway Jr. speaking with the media, the three senior managers sat down for brief interviews.
U-M Senior Manager Danny Ackerman
On his experience as a manager for the U-M men's basketball team ... "My experience working as a manager for the men's basketball team has been invaluable. Coming in as a freshman when we were 15-17, I have learned so much as I have watched and helped the coaching and support staff bring the program back to where it should be. Sometimes I have to pinch myself when I think about my college experiences -- whether it was traveling to Maui or winning a Big Ten championship -- because I have been so lucky to experience all of it, especially to experience it alongside the great friends I have made within the program."
On his favorite game/favorite moment as a manager ... "Our coaching staff starts every meeting or film session with the same responsive greeting that ends in Coach Beilein saying 'We are going to be ...' and the players responding 'champions.' The best moment of my four years so far was when we gathered for a meeting after we celebrated clinching the Big Ten championship last year. Instead of the usual ending to the greeting, Coach Beilein said 'And we ARE ...' with a thunderous reply of 'CHAMPIONS!' Nothing feels better than accomplishing a goal you focus on for over a year. I only hope there is more to come before it is all said and done."
On what he's learned and what he will take away from his time as a manager... "I have learned so much from our staff and players, as well as the other two head managers, Brandon (Verlinden) and (Matt) Sawyer. My time as a manager leaves me confident and prepared for whatever tasks and goals are in front of me because I have learned so much about hard work and what it takes to succeed. Throughout the highs and lows of my four years, I have learned how to both soak in the good times and weather the bad times."
U-M Senior Manager Matt Sawyer
On his experience as a manager for the U-M men's basketball team ... "My four years as a manager have been incredible. This experience has lived up to every bit of the hype I associated with it when I started in September of 2009. The highs and lows of the season have been exhausting each year, but all of the moments that have nearly made my heart stop made this job all the more fun. Even more, I have a brotherhood in Michigan basketball that will last a lifetime."
On his favorite game/favorite moment as a manager ... "College Game Day in 2012 was the most memorable experience for me. I am an Ohio kid, so every game against Ohio State is personal for me. Being able to play the Buckeyes on the biggest stage in college basketball, while being such an integral part of the team, was awesome. More importantly, we won the game on our way to a Big Ten championship."
On what he's learned and what he will take away from his time as a manager... "I have learned so much during my time as a manager, but the most significant takeaway has been the importance I have learned to place on each moment with the special people in your life. 'Make today your priority' has become my mantra, and it has become such after so many small moments that have had a huge impact on me as a member of this program. I've come to appreciate the commonplace occurrences now, knowing that they may not seem so common when it is time to reflect on them."
U-M Senior Manager Brandon Verlinden
On his experience as a manager for the U-M men's basketball team ... "My experience with the team has been great. I felt part of the Michigan basketball family from the very first practice and over the past four years have met friends and made memories I will remember forever."
On his favorite game/favorite moment as a manager ... "My favorite moment as a manager was when Coach Beilein gave me the opportunity to dress for the Michigan State game my sophomore year. It was the final home game of the season, and I had been practicing with the team for a few weeks when Coach Beilein allowed me to suit up and run down the tunnel wearing the Maize and Blue uniform. Dressing for the University of Michigan was something I used to only dream of and because of this opportunity, it is now something that I will never forget."
On what he's learned and what he will take away from his time as a manager... "There is so much that I have learned since I first became a manager as freshman. I learned a great amount about the game of basketball from the coaches and players, but I also learned many off-the-court lessons, and that is something that I never expected. Our Michigan basketball core values are really something that has stuck with me these past four years, and I am sure that they will not be forgotten as I transition to life after Michigan."
Contact: Tom Wywrot, Whitney Dixon (734) 763-4423
» Learn about Michigan men's basketball season tickets for the 2017-18 season.


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Neuro-linguistic programming is most commonly known as NLP. So, what does it mean? How does it work? These are the most important questions which require proper answers.
To begin with, you need to understand that NLP is an approach to personal development, psychotherapy and communication. It was created in the 1970s in the United States of America. The idea is as follows: the process how top people from different fields achieve such outstanding results is viewed. What it means is that it is possible for anyone to master those skills. In such a way, the person will be able to improve their productivity and effectiveness.
As soon as you start researching the issue in detail, you will realize that the subject has quite rich history. Thus, it presupposes that you will need to allocate a lot of time in order familiarize yourself with all necessary information regarding the subject in question. In order to make this process simpler, feel free to take a look at all available materials on the subject of neuro-linguistic programming here … Neuro-linguistic programming
This is a great example of the way one should write a top-notch PhD level essay. Nevertheless, you may not employ the parts of this article into your piece of writing as your paper will appear as plagiarized. It is highly recommended to avoid the usage of free samples or any Internet content that cannot be cited properly. Using such information may threat you academic performance or even be a reason of expulsion. Therefore, a great idea is to turn to the online writing service, which provides the papers written from scratch by the professional writers. Our writers specialize in a great variety of subjects and grant 100% originality. Moreover, every order goes through the plagiarism detection software, which lets us spot the plagiarism before the assignment is sent to you and resolve the issue immediately. Get started now and you will never regret it!

subset: commoncrawl


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You can watch Father Brown Season 05 Episode 09 online for free on megashare by clicking the play button above. This movie is hosted on vidtodo-com and was not uploaded by us or any person affiliated with us. If the stream is too slow, try another link found on the left. Here you can see other hosters which might be faster! If you're trying to watch Father Brown Season 05 Episode 09 and it isn't loading, please check our Help section before reporting it as a broken link.
is a comedy series set in Ancient Rome. Not likey to be immortalised in history, Marcus, Stylax and Grumio are just everyday plebs. The series follows three desperate young men from the suburbs as they attempt to get laid, keep their jobs and climb the social ladder in Ancient Rome.
The first leg of the USS Enterprise's five year mission takes them into uncharted territory. There the Enterprise is nearly destroyed and strands Kirk and his crew on a remote planet with no means of communication. Kirk must then work with the elements to reunite his crew and get back ...
Comedy that goes behind the scenes of a telenovela and its star, whose off-camera life rivals the drama of her onscreen story lines.
The survival of the human race depends on two strangers forced to come together despite their differences.


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These are all amazing. Great job on their outfits and for making their personalities shine through.
I love how before you even look at the picture, while you're reading the post, you seem to create your own picture for each of these lovely girls, then when you finally look, of course Inslee has them look exactly what you pictured them to be…but better.
I love all the poses, especially Margaret on the stool! And great descriptions, I love "occasional lapses into a British accent." lol
Kelly's pic is divine! Love the colors!


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Status: Closed
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
George I. Karp, MD provides oncology services in New Brunswick, NJ. Oncology includes the diagnosis and treatment of breast cancer, skin cancer, prostate cancer, and many other forms of cancer.
Contact George Karp, MD at (732) 828-9570 for specific information about cancer treatment in New Brunswick, NJ.
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George Karp, MD practices as an Oncologist in New Brunswick, NJ.


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Being able to review something outside of my normal scope and by such a talented author was a real treat, but before I say more, here are the cover and synopsis:
Some stories are based in true events, some are inspired by true events. I believe the discrepancy lies in 50%. If more then half the story is based in fact it is based on a true story. If less the 50% of the story is based in fact it is inspired by true events. I think the reader needs to decide that for themselves because some stories should never be told.
The perspective of the narrator is captivating. The emotions and fervor in this style cannot be imitated.
I wanted to include that particular note of praise because it struck such a chord with me. THE FARM contains something that most novels lack these days. Was it his rawness that struck me so deeply? Was it the coldness of his main character? Was it the depth of unresolved struggle?
One thing is for certain, Burrows knows no fear. His writing will strike you. It will choke you. I had to read the book in sections because I would be so overwhelmed by the gravity of the characters' situations, their reactions to those situations, and the shifting story that I would need to take periodic breaks and remember how to breathe.
In a world of stories with characters who embody what we might want to be, Burrows writes dark, real characters who will scare you. He also addresses relevant topics in our society in a fearless manner--like being transgender, dealing drugs, and growing up in a distant and dysfunctional family.
I have to say again though, to my typically young adult audience, this novel is not for the faint of heart. There are graphic scenes of violence, massive amounts of drug use, gang wars, sexual exploits, and more. And Burrows deals with these scenes in an unapologetic and beautifully brutal manner.
For my readers who are seeking something that pushes the envelop, that will make you dream in the color of blood, and will make you questions literature as we know it, this novel is for you. If you are looking for those qualities in your next read, then I dare you to pick up a copy of this book and let it burn you.
You can pick up a copy of THE FARM here.
Be sure to leave your comments on this review, as well as to leave a raving review for the author!
I'll see you next month, readers! Until then...


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Also, for whatever reason, the non-standard (?not sure what those are.
.jpg I think) attachments don't always make it into the Mallorn photo
archives (where a lot of folks do their reading). None of Al's
attachments are there as photos. I wasn't brave enough to try to
download them for fear of those sneaky evil lurking worms...
I sent an enormous attached file photo of PACIFIC DESTINY that went into
limbo before I learned how to make smaller file sizes. Apologies to all
who were stuck waiting for that one to download!
Linda Mann Tennessee
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America's Dirtiest
There's a program on one of the Discovery channels, hosted by Mike Rowe, called America's Dirtiest Jobs. One of the jobs featured in the series was cleaning up the hog yards, running the slop and the streaming, excrement and urine filth down a chute. Rowe, in fishing waders, surgical mask and goggles, was waste deep in the stuff, shoveling the terrible mixture onto the chute that sent everything into a huge vat, where something was done to it and I don't know what because I changed the channel because I didn't want to know. I could easily imagine an emotion akin to "just make it go away."
The story in today's (July 3) paper, "Panel Questions State Dept Role in Iraq Oil Deal" (http://www.nytimes.com/2008/07/03/world/middleeast/03kurdistan.html?_r=1&th=&emc=th&pagewanted=print), illustrating the Bush administration's involvement in A-N-O-T-H-E-R — "Oh Lord, how many have there been now?" too-dirty-to-even-want-to-want-to-touch scandal sent my mind immediately to that hog slop episode. The stench and excreta indelibly and intimately associated with these past seven years-but-seems-like-seven-centuries any more leaves me retching in anticipation of when — "Oh please God make it be over" — it might all finally come to its end.
While you can click on the link to the story, suffice it that it involved Ray L. Hunt, a Texas multi-kazillion dollar oil magnate and a strong supporter and very close friend of George W. Bush, had negotiated an oil deal with the Iraq Oil Ministry, in knowing violation of the laws of Iraq and with the full knowledge of Bush's State Department.
The violation of Iraq law is because Iraq law forbids making such a deal prior to the conclusion of oil-revenue sharing legislation and without the approval of the Iraq central government, neither of which to date have occurred.
Within the past few days, it was reported that Chevron, Exxon-Mobil, and British Petroleum are also set to ink no-bid contracts for Iraqi oil.
And 4,200 American soldiers and marines died for this? At least 30,000 American soldiers and marines have been savagely mutilated for this? The United States has gone into debt perhaps as much as $3 TRILLION for this? Perhaps a couple hundred thousand Iraqi civilians have died, more than a million seriously permanently wounded, and a few million have been forced to flee the country, their country, the land of their birth . . . for this?
And you know someone who voted for George Bush, you know someone who yet claims to apologetically support this president, and you know someone who claims to support John McCain, the aspirant to the presidency of your country, of my country, of our dear and beloved country, and you have not told this person he or she is "dead to you"? And why, in the name of all on earth and heaven that is decent and good and just have you not?


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New Delhi, Jan 8(ANI): Union Road Transport and Highways Minister Kamal Nath has appealed to all the stakeholders to join hands with the government in its effort to make the roads safer and develop sustainable transport system across the country.
Speaking at the valedictory function of the 22nd Road Safety Week here today, Nath said: "Indeed, this is the time to review and plan for all our road safety related activities not only for the year 2011, but also for the new decade, which has been rightly proclaimed by the United Nations General Assembly as decade of action for road safety".
Talking about the challenge thrown by the tremendous growth of transport infrastructure and services in the country, the Minister enumerated the various steps and initiatives taken by the Ministry, as well as many other measures to ensure road discipline and road safety.
At the occasion, Nath also gave away the Transport Minister's Trophy to the winners and runners up for the year 2007-08 and 2008-09.
The winners for 2007-08 are State Transport Haryana (in the Mofussil category), Himachal Road Transport Corporation (Hill Service) and Bangalore Metropolitan Transport Corporation (Urban Service).
The winners for 2008-09 are Punjab State Bus Stand Management Co. Ltd. (in the Mofussil category), Himachal Road Transport Corporation (Hill Service) and Delhi Transport Corporation (Urban Service).
The Transport Minister's Trophy has been instituted by the Road Transport and Highways Ministry to recognize the State Transport Undertaking (STUs) with the lowest accident rate record. (ANI)


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The Elliott House Bed & Breakfast
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
Travel Blogs from Beulah
Small side trip - State and Bijou Theatres.
... br>
I wasn't actually aware of the Bijou until I arrived, and it is certainly unique. In a building in the park by the bay, it was built as a museum/gallery, but the Festival leased the building from the city and converted it into a smaller cinema than the State, but really helping them with programming ...
Bear Lake, Idaho
... his lofty perch, his hand to the bank & his back to the church!"
Careful observation of the statues orientation confirmed this limericks veracity.
Beautiful drive from Ogden to Bear Lake today with fall colors turnings the trees a riot of brilliant colors against an achingly blue sky.
A walk to the lake, crisp apple picked from the tree here at the B&B, and fish dinner ends our day.
Time to head South.
... MI to attend Art Prize for a couple of days, then on south. I am not sure at this point what other stops we will make. That's one of the good things about being retired and traveling in an RV, you can travel when and where you like. ...
T-minus 9 hours and counting!
... Since then we have had Senior pictures, college visits and fall sports tryouts. After a difficult decision Pearson decided to run Cross Country instead of playing soccer this year......too many conflict with Band and his Drum Major commitments. It's lots of work but he is enjoying being with his many friends on the team. It's too bad that he wasn't able to play ...
Yesterday (1963)
... with colorful psychedelic patterns. In the mid-60's, when "The Beatles" wore the Nehru jacket named after the Indian prime minister, I had to have a hip-length tailored coat with a mandarin collar also. In 1980, my heart ached when I learned that John Lennon was shot and killed at the entrance of the building where he lived in New York City. He and his wife, Yoko Ono, were returning ...
Other places to stay in Beulah
Windermere Inn7723 Crystal Dr, Beulah | B&Bfrom $89


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John Elkington
Founding partner and executive chairman of Volans (2008 to date), also co-founder of SustainAbility (1987–2008, where he remains a non-executive member of the board) and of Environmental Data Services (ENDS, 1978), John Elkington is a world authority on corporate responsibility and sustainable development. In 2004, BusinessWeek described him as "a dean of the corporate responsibility movement for three decades." His first involvement in the field: raising money for the newly formed World Wildlife Fund (WWF) in 1961, aged 11.
Focus: Business, Ethics, Sustainability, Global
Link: http://www.volans.com/people/team/john-elkington/
Related Resources:
- Sustainable Civil Society Is the Economy's Immune System (Innovations)
Last Updated: Jun 05, 2012


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The digital landscape has been dispersing rapidly over the last 12-24 months and with ever more scattered audiences and fragmented social platforms, brands face a bucketful of challenges. To thrive in this highly competitive environment, digital marketers need to constantly be on their toes and stay up-to-date with the latest trends. In this deck we share 130 stats around the 7 social media trends that we see dominating 2015. To read the full blog and to understand the full scope of these developments visit http://www.emarsys.com/en/resources/blog/the-7-social-media-trends-dominating-2015/
Download 130 stats about the 7 social media trends dominating 2015
- 1. sCommerceStartupsFMSocial commerceis the evolution and maturation ofsocial media meets shoppingHeidi Cohen


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JA's mission is to prepare and inspire young people for success in the global economy. Founded in 1949, Junior Achievement began by teaching the skills of entrepreneurship to high school students. Now JA helps students from kindergarten through high school learn skills related to financial literacy, workforce readiness and entrepreneurship. JA is able to accomplish its purpose with the financial and volunteer support of a diverse pool of donors. Donors feel their gifts to Junior Achievement are a solid investment in the future of our young people.
JA of Kentuckiana serves students in 26 Kentucky and Southern Indiana counties
Ms. Debra Hoffer
Education, Economics, Children, Business, Entrepreneurship, Elementary, Free Enterprise, Job Skills
Also Known As
See more addresses
Main Address
aka Junior Achievement of Kentuckiana, Inc 1401 W Muhammad Ali Blvd
Louisville, KY 40203
Elementary, Secondary Ed (B20)
Education N.E.C. (B99)
Secondary/High School (B25)
IRS Filing Requirement
This organization is required to file an IRS Form 990 or 990-EZ.
How does this organization make a difference?
Self-reported by organization
What are the organization's current programs, how do they measure success, and who do the programs serve?
Program 1
Thousands of volunteers help the Junior Achievement program by reaching out to nearly 50,000 students every year. Classroom volunteers use the age-appropriate themes and hands-on activities of Junior Achievement's elementary program to help young students recognize their place in this world. Students learn how each person and each family play a part in our economy, and how cities, states, and businesses work. In the high school programs, students translate abstract classroom theory into real-life applications. They also learn how economics affects the world as a whole. When presented with problem-solving situations, students sharpen their decision-making and leadership skills to become ready for the real workforce.
Program long term success
We are a growing number of volunteers, educators, parents, and contributors who reach out to 7 million students each year, in grades K-12.
Program success monitored by
Not available
Program success examples
Not available
Population(s) Served
Program 2
Financial Literacy, Work Readiness and Entrepreneurship Programs
The mission of Junior Achievement of Kentuckiana is to inspire and prepare young people to succeed in the global economy. JA's age-appropriate classroom and experiential programs begin at the elementary school level, teaching children how they can influence the world around them as individuals, workers and consumers. The learning continues through the middle and high school grades, as students prepare for the economic and workforce issues they will face in the future. Program content is correlated with state and local learning standards. JA uses classroom lessons taught by volunteers and teachers, as well as hands-on experiences in learning laboratories to help young people understand the economics of life.
Program long term success
Participants will be statistically more likely to complete their education through grade 12 (the graduation rate for students with two JA program experiences is 93% vs. 55% nationally); Participants will be more likely to attend college immediately following high school (per national evaluation).
Program success monitored by
Student pre-post tests; student surveys, volunteer surveys; educator surveys.
Program success examples
Serving 48,000 students this year, JA of Kentuckiana is the region's largest organization dedicated to educating students about workforce readiness, entrepreneurship and financial literacy through experiential, hands-on programs. Our area office strives to serve students four times during their school careers, twice in elementary school, once in middle school and once in high school. A close working relationship with local schools, the generosity of area contributors, 3,200 enthusiastic volunteers, a dynamic board of directors and a passionate staff have allowed us to experience dramatic growth in recent years. We are pleased to report that JA currently reaches:
· 94% of students in the Louisville Metropolitan Statistical Area with a JA elementary classroom program;
· 93% of local 5th grade students with Sam Swope JA BizTown;
· 80% of 7th or 8th grade students with Chase JA Finance Park, the area's deepest impact, experiential programs;
· 33% of high school students; JA is poised to dramatically increase its high school programming this fall by serving all of Jefferson County Public Schools' 9th grade students with a new, locally-developed career exploration program, JA Real Jobs, Real World (see enclosed brochure).
Junior Achievement of Kentuckiana delivers an average of 15.4 instructional contact hours per student per year, compared to the national JA average of 7.6 hours. With an annual operating budget of $1.5 million, we believe that we are giving the community a big bang for its buck!
Junior Achievement is committed to ongoing evaluation and quality assurance of all JA programs. In the past 4 years, 96% of JA's current programs have undergone a comprehensive, nationwide evaluation by a third-party evaluation firm. Findings prove that JA, at all levels, is preparing students to develop successful financial management habits, empowering them to explore the potential of becoming an entrepreneur, and providing them the skills necessary to succeed in a global workforce. The research also shows that JA programs positively impact students' ability to work together in groups and, when compared to their non-JA counterparts, JA students have significantly-improved critical thinking skills.
Population(s) Served
Children Only (5 - 14 years)
Youth/Adolescents only (14 - 19 years)
JA of Kentuckiana serves students in 26 Kentucky and Southern Indiana counties
Funding Needs
Junior Achievement needs $1,400,000 in donations from the private sector or foundations in order to serve 48,000 students each year. The need will grow as JA serves new groups of students. Each year teacher requests for programs go unmet because of limited resources.
External Reviews
Source: greatnonprofits.org
The review section is powered by Great Nonprofits
The people, governance practices, and partners that make the organization tick.
Ms. Debra Hoffer
Debra Hoffer, President, has served children in the Louisville Metro Area more than 29 years. Before appointed president to Junior Achievement of Kentuckiana she held the positions of Executive Director of the Louisville Ballet and Managing Director for Stage One, the Louisville Children's Theatre. Hoffer earned an MA in Arts Administration from Indiana University and a BA from the University of Strasbourg, France.
Donald J. Kelly
Wyatt, Tarrant & Combs LLC
GuideStar worked with BoardSource, the national leader in nonprofit board leadership and governance, to create this section, which enables organizations and donors to transparently share information about essential board leadership practices. Self-reported by organization
Does the board conduct a formal orientation for new board members and require all board members to sign a written agreement regarding their roles, responsibilities, and expectations?
Has the board conducted a formal, written assessment of the chief executive within the past year?
Have the board and senior staff reviewed the conflict-of-interest policy and completed and signed disclosure statements in the past year?
Does the board ensure an inclusive board member recruitment process that results in diversity of thought and leadership?
Has the board conducted a formal, written self-assessment of its performance within the past three years?


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Tuesday, May 23, 2017
- The end of Taiwan's most controversial death penalty case this week has "punctured the myth that the judicial system never makes mistakes in death penalty cases," Judicial Reform Foundation (JRF) executive director Lin Feng-cheng told IPS.
A panel of three High Court judges overturned murder convictions and capital sentences Aug. 31 against the so-called 'Hsichih Trio' after 21 years of legal battles. Supporters of human rights and opponents of the death penalty gathered at the Taiwan High Court Criminal Appeals building cheered after Su You-chen, chairman of the Chinese Association for Human Rights, announced the "not guilty" verdicts for Su Chien-ho, Chuang Lin-hsun and Liu Bin-lang.The case began on Mar. 23, 1991 when a couple, Wu Ming-han and his wife Yeh Ying-lan, living in Hsichih township near Taipei City were found robbed and murdered, having been stabbed 79 times.
On Aug. 13 1991, Wang Wen-hsiao, a neighbour then serving in Taiwan's Marines, was detained and then formally arrested two days later, based on a fingerprint found at the murder scene.
Wang initially confessed to have conducted the killings alone, but police doubted that Wang could have killed the couple by himself.
During interrogations by Hsichih precinct police, Wang named three other 19-year-old associates, Su Chien-ho, Chuang Lin-hsun and Liu Bin-lang for helping him murder the couple after robbing their home and raping Yeh.
The three suspects confessed to the crimes to the police and were charged with murder under the Act for the Control and Punishment of Banditry at the time, which provided for mandatory death sentences.
Wang was convicted in military court and executed on Jan. 11, 1992 and never directly faced Su and the other two suspects.
After judges refused to accept their claims to have made false confessions under torture, Su, Liu and Chuang were convicted in the Shihlin district court on Feb. 18, 1992 and lost two appeals to the High Court before the Supreme Court finalised their guilty verdicts and imposed death sentences on Feb. 9, 1995.
Although they would normally have been executed within three days, then justice minister (and now president and ruling Chinese Nationalist Party chairman) Ma Ying-jeou refused to sign the execution orders, returning the case to the Supreme Court due to the lack of direct evidence.
The Control Yuan, Taiwan's watchdog branch of government, launched a probe into the Su Chien-ho case in March 1995 that found numerous errors in the investigation and trial proceedings by the Hsichih police bureau, the Shihlin district court and the High Court.
The "Hsichih Trio" or "Su Chien-ho" case became the focus of a major global human rights campaign, and spurred the drive by Taiwan civil society groups to push for the abolition of the death penalty.
A turning point came in June 2008 when renowned criminologist Henry Lee Chang-yi undertook a detailed investigation of the crime scene and forensic data on behalf of the defendants and concluded that "it is extremely likely that this case was committed by Wang Wen-hsiao alone."
"This critical forensic research came about because of civil society efforts and not the court," Judicial Reform Foundation executive director Lin Feng-cheng told IPS. "It was only because this case attracted too much attention and even became the subject of an international campaign were we able to persuade Henry Lee to come here."
Speaking for the trio, Su Chien-ho said "21 years of trials and retrials has turned us into middle-aged men and our youth is long gone, but we now only have feelings of gratitude and hope to return to normal lives."
"Senior judicial officials continue to attempt to persuade society that the judicial system never makes mistakes and this myth has blinded many people, but the Su Chien-ho case is an example of a finalized death penalty verdict that was overturned and shown to be wrong," the JRF spokesman told IPS.
"If their death penalty verdicts had been implemented, they would have been executed just like Chiang Kuo-ching" – an Air Force private wrongfully executed in August 1997 after confessing under torture to a rape-murder, said Lin. "This fact shows how frightening the death penalty truly is."
President Ma, who as president has overseen the ending of a nearly five-year moratorium on the death penalty with nine executions, told reporters Aug. 31 that he hoped that there would never again be such a case and that there would no longer be cases in which confessions were obtained through improper means from suspects.


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For @sevenwaystosunday
Something for sevenwaystosunday
(I know I am not a poet but i thought some poetry might cheer you up ^_^)
The holiday season has come knocking on your door
So staying optimistic shouldn't be a chore
No matter what life throws through your door
Your family will provide love and support
Your Protag friends will provide the warmth
No matter what walks through your door
We will be there to hold your hands
In reality and in words or phrases or better yet in story telling
Rely on us, you are not alone
So watch some "Holiday in handcuffs"
And we will watch it with you!
Hugs to Sevenwaystosunday !
January 15, 2014
That one moment in time
A first memory of childhood that I remember
Is not all fuzzy and lovey do vie.
It's not the gazes filled with love of family
It's not the dolls or plush toys that my parents could buy on their salary
It's not the quarrels with my sister over broken colored pencils
That one moment in time
A first memory of childhood that I remember
Is about a gun held to my face by a laughing lunatic
Who laughed at how he was in power and I was fearful
He tied my father with heavy ropes and went through the house
Taking what pleased him all the while making his friend stand before a small child
Who was holding a doll and looking at the scene before her
With a gun straight at her face
That one moment in time
A first memory of childhood that I remember
Is not all fuzzy and lovey do vie.
It's something that I pushed away
Deeper and deeper into my mind
I took out a key and locked it away
Locked it away in a chest, leaving the key in
But sometimes with trips down memory lane
The key moves on its own twisting inside until the chest bursts open
Bringing back that moment in time
A first memory of childhood that I remember
A moment that I will never be able to forget
January 22, 2014
You have one wish that your heart desires
Or maybe two or three or four…should I go on?
Light a candle for each wish you have
Keep it close to your heart and wish it so
Wish your wish in rhyming tone
Ending with a wanting need
Each candle of different color creating a rainbow in your heart that
Absorbs all the negative
All the pain and suffering
All bad thoughts
Replacing with your heart's desires
Replacing with song and dance in heart
Replacing with warm feelings and happy thoughts
With a need to write about the Sun, Moon and the stars
Don't forget to add asteroids and planets too
But if you forget about planets next time
Just think "Moon Prism Power!!!"
(Sailor Moon Anime-let me know if you need a link if you haven't seen it….it was one of the shows I watched in English when I came to US at 9)
In all to an end
The point this poem tries to say
Is Happy Birthday Dear
May all your wishes come true
Keep the candles in your heart
For @sevenwaystosunday


text:
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An honest, friendly, reliable ex-military central heating engineer and plumber based in New Romney, serving the Romney Marsh and surrounding areas.
I am Natural Gas (mains) and LPG qualified with Gas Safe registration (No. 550381). I am also qualified to work on Unvented Hot water systems.
I strive to accommodate customers and understand that 8-5 isn't convenient for everyone so am happy to make calls in the evening or weekends if necessary. I install, maintain and repair boilers and central heating systems along with the hot water tanks, install gas cookers, maintain and repair gas fires, carry out Landlord Gas safety inspections, Caravan gas safety inspections, install full bathrooms (with Meljen Tiling) or just individual items like dripping taps and leaky toilets as well.
For more information, please visit my Facebook page.
Ashford, Romney Marsh, Rye, New Romney, Folkestone, Hastings, Canterbury, Kent


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Home > Archives > Healthy Recipes > 2005 > Chocolate Eclair Graham Cracker
Chocolate Eclair Graham Cracker Recipe
Just plain healthy recipe...
Chocolate Eclair Graham Cracker is a scrumptious version of the delicious eclair dessert with fewer calories and less fat. Plus this recipe adds calcium - it's a definite keeper!
Recipe Ingredients
1 box low-fat honey graham crackers
3 cups cold skim milk
2 3.4-oz packages vanilla fat-free instant pudding (do not use sugar-free)
1 8-oz. package fat-free cream cheese
1 8-oz container fat-free Cool Whip whipped topping, thawed
1/4 cup skim milk
2 tablespoons butter or margarine, softened
2 tablespoons honey
2 ounces unsweetened chocolate, melted
1-1/2 cup sifted powdered sugar
Cooking spray
Recipe Directions
Coat a 13 x 9-inch baking pan with cooking spray. Arrange 7-1/2 graham cracker sheets in bottom of the pan.
Make creamy filling by combining 3 cups milk, pudding mix and cream cheese with a mixer for about 1 minute, until thick. Fold in Cool Whip.
Spread half of filling mixture over the graham crackers, then top with another layer of graham crackers and repeat with filling and graham crackers (ending with a third layer of graham crackers on top).
Recipe makes six servings.
For the chocolate topping, combine 1/4 cup milk, butter, honey and chocolate with a mixer until well blended. Gradually add powdered sugar, beating until blended well.
Spread chocolate topping over graham crackers and cover loosely with foil. Chill for at least 4 hours. Cut into 18 squares.
Nutrition Information
Yield: 6 servings
Serving size: 1 portion (1/6th of dessert)
Calories: 234; Total Fat: 5.8g; Cholesterol: 3mg; Carbohydrates: 41.5g; Protein: 5.4g; Fiber: 0.8g; Sodium: 352mg


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Long Black Kidskin Leather Half Finger Gloves, Silk Lined, 16-bt
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The simple elegance and the softness make these women's Goldenrod / Light Orange-Yellow Italian leather gloves a "must have" for every occasion, Lined in Cashmere.
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Cast your home in vibrant light with Natural Spectrum illumination from Verilux. These frosted, dimmable halogen bulbs are made with neodymium, an abundant earth mineral extracted from sea water. It filters out unnatural yellow hues seen in illumination from standard bulbs – hues that compromise the integrity of your view. And, because they're more energy efficient, you'll be saving money over the life of the bulb, compared to standard incandescents.
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- Description
- Data Sheet
- Suitable for (2)
- Reviews
Italian tuning specialists Polini are introducing their outstanding P.R.E. racing kit (Polini Racing Engine), and this is the matching exhaust: Polini Exhaust P.R.E. 70cc. The expansion chamber is made of thin sheet metal pieces (rolled and welded) with a protective clear coat, the silencer is made of aluminium.
The exhaust was specifically designed for the new 70cc P.R.E. cylinder by Polini to support the engine's considerable torque and power, especially at high rpm. It was also designed as integral part of the entire P.R.E. engine / crankcase (70cc) for Piaggio Zip SP.
Name Polini Exhaust P.R.E 70cc Piaggio Item No. P200.0401 Brand Polini Homologation No Product Line Hyper racing Silencer Finish Aluminium Silencer Mount 3 screws
Your product goes with the following manufacturers and their models:
Zip 2 SP 50cc LC
Zip SP 50cc LC


text:
Wellington Square is designed to meet the needs of children aged 7-13+ who are having difficulty in learning to read. It provides straightforward progression through all 5 levels of the scheme, from wordless picture books to storybooks with full-text.
"synopsis" may belong to another edition of this title.
£ 25.32
From Spain to U.S.A.
Book Description Looseleaf. Book Condition: Muy Bueno / Very Good. Bookseller Inventory # 100000000669542
More Information About This Seller | Ask Bookseller a Question


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New Delhi, Feb 12 (PTI) Maintaining that no "proper"consultations were held with stakeholders before finalisingthe Press and Registration of Books and Publication Act, theIndian Newspaper Society today said concerns of the industryshould be addressed before the Bill is tabled in Parliament.
Clarifying its position, INS President Kundan R Vyassaid that the Ministry of Information and Broadcasting startedworking on effecting certain changes in the PRB Act in 2005and subsequently followed it up in early 2010 and the purportof the amendments at that time was only to provide efficientand better service to the newspapers.
However, the newly named Act contain many provisionsand clauses which "are impediments to the smooth functioningof the fourth estate of our democracy.
"The draft of the new Act was sent for comments to thePress Council of India at a time when members of the councilwere preparing to hold their last meeting during their term inoffice," he said in a statement here.
The members, therefore, could not devote time todiscuss the issue and they clearly indicated to the Ministryof Information and Broadcasting that the new council whenconstituted some time in February 2011, will take up thisissue for discussion and send their detailed comments andsuggestions, he added.
Vyas said that the INS after studying the new Act nowcleared by the Union Cabinet, will shortly send itssuggestions and comments to the Ministry of Information andBroadcasting. He urged the Minister to await INS response andaddress concerns of the industry before placing the Bill inthe Parliament.
The I and B Ministry had yesterday said it hasconsulted all stakeholders, including Indian Newspaper Society(INS), and incorporated their suggestions before the UnionCabinet cleared a bill on registration of books andpublications.


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ED Magedson – Founder
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Item description for Where Is Heaven? What's It Like There? What Do You Do There? by Steve McKenzly...Overview
What's It Like There? What Do You Do There? What is heaven? According to the Bible it's a beautiful place in the spiritual world, beyond imagination, where our Lord and Savior resides. Others reside there also according to the Bible. Christians who die go there in spirit until the resurrection, at which time, they will receive new bodies.With these new bodies they will be able to come and go from the spiritual to the physical at will.They will have a body like Christ,without restriction, unlike the bodies they dwell within now. Heaven is peace, love, joy, serenity, happiness and so on. We can feel any or all of these qualities as long as we keep our hearts and minds on the Lord. In fact, if we dwelled on God's love we would immerse into a heavenly aura that would emanate us into a luminous state of bliss. There will be biblical phrases as well as my own personal views to describe "WHERE IS HEAVEN?""WHAT'S IT LIKE THERE?""WHAT DO YOU DO THERE?" The Bible is a very reliable informative source to use because no part of it has ever been proven false and that's where every true Christian's faith lies. The metaphysical principles to understanding the mechanics of "how" is another source used in compliance to recognize scientific procedures to merge with biblical truths. Hopefully, this book will find it's way into every home, Christian and non-Christian alike, and help all to understand that God and His Word are the most important source for eternity and where we choose to spend it.
Promise Angels is dedicated to bringing you great books at great prices. Whether you read for entertainment, to learn, or for literacy - you will find what you want at promiseangels.com!
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Kryptek Cadog Shield Jacket - $99.88
This soft, quiet jacket boasts quick-drying, polyester construction, ample pockets for storage and ventilation in key areas for long-wearing use, regardless of temperature. Fleece lined to seal in warmth. Ample ventilation with water-resistant, wind-blocking exterior. Jacket has pit-zip vents, adjustable cuffs and a heat-sealing drawcord hem. 100% polyester. Imported.Sizes: M-2XL.Camo pattern: Mountain Mimicry 1.0. - $99.88


text:
Webcarmonitor.com is a 1 year old domain, situated in United States. The domain is linked to the IP address 126.96.36.199 which is provided by the hosting company Microsoft.
It was registered by roberto marcio arruda fernandino , who can be reached at . The site is owned by roberto marcio arruda fernandino. Registration details show that it was registered on 08 Jan 2016 through universo online s/a and will expire on 08 Jan 2017.
The site returns a status code of 200. It is being generated using qTranslate-X 188.8.131.52.


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UNB Varsity Reds Thread (Part 2)
View Single Post
Better Red than Dead
Join Date: Mar 2009
Location: Freddy Beach, NB
Posts: 1,089
vCash: 500
UNB Schedule
The AUS Site has published the 2012-13 schedule.
UNB opens the season at home vs STU - only the second time in almost 40 years that they have opened the season. The first time for UNB as host (UNB was the visitor in the first game - 97/98 Oct 15 (M. Kelly) UNB -8 vs STU -6)
This is followed by a home game vs UdeM - which is strange as they would have normally played that game on the road.
The next two(2) weekends are on the road in NS (SMU/X followed by ACD/DAL)
UNB's first game against STU in the GHC is Fri. Nov. 9th.
The season is a 16/12 split, so it's more of 3/5 - 2/5 split than a 50:50.
UNB is playing 2 games every weekend except for the last weekend where everyone (all 8 teams) are just playing on Friday (UNB hosts UdeM in that game). So, exhibition has to be done before Oct. 12th as there are no gaps in the schedule (other than Christmas).
UNB has only one(1) Wednesday game (hosting STU) between two road weekends (at X & SMU, then host STU, then visit PEI & UdeM) in mid January - not a good time to have a slump. I wonder if they will stay on the road or return home to turn around the next day?
So - getting off to a good start is important as there are 4pts for every team each weekend.
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HVD (holographic versatile disc)
Holographic versatile disc (HVD) is a holographic storage format that looks like a DVD but is capable of storing far more data. Prototype HVD devices have been created with a capacity of 3.9 terabytes (TB) and a transfer rate of 1 gigabit per second (1 Gbps). At that capacity, an HVD could store as much information as 830 DVDs or 160 Blu-Ray discs.
Letters from the Editor: 2016 State of Storage
Rich Castagna – the VP of Editorial, Storage – shares his candid, expert, and often very funny view on today's storage market. In these six "Letters from the Editor," originally featured in our monthly Storage magazine, Rich covers topics such as flash, data storage, SDS, storage hardware, data protection, convergence, and more.
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To increase capacity, holographic storage uses laser beams to store digital data in three dimensions, rather than in two dimensions as in CD and DVD media. HVD is, essentially, a holographic layer built on top of a conventional disc. The HVD process uses a blue-green laser beam, used for reading and writing data, collimated (made parallel) with a red laser beam, which is used for servo and tracking.
In the recording process, the initial laser is split into two beams. One of the beams passes through a device called a spatial light modulator (SLM) and combines with the direct beam to produce a hologram in the physical medium. To recover the data, another 532-nm laser is directed into the hologram, which diffracts the laser beam. The resulting image constitutes an optical reproduction of the original recorded data. A photosensitive semiconductor device converts this optical data into the original digital files.
The first working HVD systems for the enterprise are expected to be shipped in 2006, with consumer HVDs and drives to become available in 2008 or later. The initial target market is high-volume mass storage, such as digital television (DTV) broadcasts and document libraries in large businesses and government agencies.
Members of the HVD Alliance include Fujifilm, Konica Minolta and Mitsubishi. According to the Alliance, HVD will eventually replace DVD.
Continue Reading About HVD (holographic versatile disc)
Dig Deeper on Disk drives
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Notes on privacy taken by Dai Griffiths.Professor of Educational Cybernetics Institute for Educational Cybernetics (IEC) Bolton University "I have a hunch. Students will have a backlash against maintaining themselves in digital wolds. We are all public now... The kids will get to the point where they recognise that these are not authentic relationships. Is this a plausible hunch? "One now has the expectation to be able to track others. Kids grow up with an expectation of this reality. Our perception of reality won't be the same as theirs." "I've had conversations with 18-19 year olds, and heard that they want to get away from that constant ability to get away from that need to craft themselves." "My hunch would be that a deviant position will develop of anti social tracking. Drop out." "Most young people know the risks of having material on facebook. But they don't accept it is as a real threat to them" "Email is a public system, are we aware of it? If you are aware of that, you can just carry on... or you may be in a position to have another system. The way things are is made up by the data processing rules of Google et. al. Could you not get to the point where you get back to circa 1985 when the exchanges around the internet were not being monetised, or being used for monitoring and surveillance?" "Universities use if for data analytics. I as a teacher find that very uncomfortable. The institution wants to help the student, but they are distancing the learner from their own learning." "How can we subvert that system with the students? How much are we working with digital technologies in collaboration with students, how much are they surveillance technologies?" "There is a parallel between Taylorism and digital programming. Is this significant?" "Or is this an over-simplification of how we see 'digital' and 'models'." "I teach IT at University level, and many of my students are on Facebook, and they have no contacts outside it. This is bad for them. Digital technology has not brought anything radically new to education. It is very undermining for teachers, who undergo character assassination online. The students are playing games, or fighting, or doing nothing online. Or sending SMS messages." "Is it a matter of misunderstanding what we do in the classroom. Is the efficacy actually the modelling of the teacher and their use of the formal models? But that discussion is hard to have in the context of eductional metrics as they stand." "How could we understand the relationship between personal models and intellectual models?" "In the real world everything is an object, with material characteristics. In the virtual world they are not. So we can't have the same models. Engineering is a real world matter. Putting together the components of software is equivalent to what happens in life." "I would like to teach my students to think about what they are doing, many of them. I would not turn off Facebook. Children need to learn to contrast sources of information."
People and projects are in silos.
@font-face { font-family: "Courier New"; }@font-face { font-family: "Wingdings"; }@font-face { font-family: "Wingdings"; }@font-face { font-family: "Cambria"; }p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0cm 0cm 10pt; font-size: 12pt; font-family: Cambria; }p.MsoListParagraph, li.MsoListParagraph, div.MsoListParagraph { margin: 0cm 0cm 10pt 36pt; font-size: 12pt; font-family: Cambria; }p.MsoListParagraphCxSpFirst, li.MsoListParagraphCxSpFirst, div.MsoListParagraphCxSpFirst { margin: 0cm 0cm 0.0001pt 36pt; font-size: 12pt; font-family: Cambria; }p.MsoListParagraphCxSpMiddle, li.MsoListParagraphCxSpMiddle, div.MsoListParagraphCxSpMiddle { margin: 0cm 0cm 0.0001pt 36pt; font-size: 12pt; font-family: Cambria; }p.MsoListParagraphCxSpLast, li.MsoListParagraphCxSpLast, div.MsoListParagraphCxSpLast { margin: 0cm 0cm 10pt 36pt; font-size: 12pt; font-family: Cambria; }.MsoChpDefault { font-family: Cambria; }.MsoPapDefault { margin-bottom: 10pt; }div.WordSection1 { page: WordSection1; }ol { margin-bottom: 0cm; }ul { margin-bottom: 0cm; } Looking at relevant methodologies Recorded by Professor Averil Loveless from University of Brighton Kick off – Matthew's interest …..e-learning background, dissatisfied with methodologies for evaluating. What is the extent to whihc it is possible to make defensible knowledge claims around technology? If we wish to progress and accumulate knowledge of different experience an take more effective control of these different situations…. It's as if the research community has acquired a pathological dynamic in which the discussion is sefl- containing… Possibility of making objective statements about learning and technology are not that difficulty … there are fundamental patterns in institutions using technology. There are issues in understanding causal efficacy … what we do and their emergent impacts. Trying to escape the reductionist thinking…. GT implies a certain reality What do we think the world of education is really like? Discussions … – This is an ontological question. – Research methods in this area have not been critiqued (Bridget and Cathy??) – Rom Harre - Roy Basker? – wrote critique of social science methodology – critique of Hume and constructions of causes. – Discussions of ontological positions, identification of research question and appropriate methods. How do we identify these questions, methods and interventions initially? How might we building models in the process? – Can we mix methods and/or methodologies? How do we explain what's going on? Was Hume wrong and causes are real. Basker talks of causal mechanisms – transitive and intransitive. Human agency reproduces and transforms social structure… Other powerful ways of posing reality? Where is the discussion happening? What might be radical methodological approaches? Cues from Kant…. Given that this is the case, what must the world be like? Look at phenomena and 'play around' and theorise. Answer … modelling. Dynamic, emerging mechanisms .. when we take a snapshot which loses the dynamics about what is going on. Do social sciences aspire to condition of pharmacology – how do we close the gap? Our thinking about open systems is limited. There is so much complexity, the pragmatic way is the only way to navigate through, in order to recognise that holistic picture is built up from different ways of looking that things in the process. The technologies enable us to model and simulate. Teacher education futures ….. Shall we set up our own inspection service to set up 'future teacher ed'? Australian initiative.. 4 big projects, 1 was teacher ed institutions .. expected to work with a few subjects in integrating technology into the subject e.g TPCK model. Developing sets of standards. Some caution about potential success – short amount of time to change attitudes and practice (less than a year). Imagine if we set higher standards than governments. The more secure universities could change the way they do admission … e.g. instead of A levels only, use 21st century characteristics. Send shocks through the system. What are the pieces that have to be in place in a system so that the core value isn't squashed? System wide change starts with the innovators and early adopters. What about the ones that don't make it? UCET needs ICT literacy folk working in the council. Internationalizing is a key theme in our funding of research in UK. Could we use work of others beyond UK to leapfrog? E.g. ISTE standards in the US. Might allow is to progress a little further. UNESCO – teacher education ICT curriculum. Used quite a lot. Where are other 'standards' …. Do people know about them? How do we as a community own our knowledge and resources? Are politicians interested in evidence? Or only in evidence that supports their policies? Politics is about the newspapers. How do we influence the editorial class? Identities of professions. E.g. English nurses gave vote of no confidence. Would teachers? Do we have a shared valued and knowledge in the profession? Would we find a global view across the profession e.g. reading? Is the understanding of the purposes of education shared? Time, context, generation, economy, capital? Would the discussion 70 years ago be similar or different? In 80s politicians attacked education and professional knowledge. How do we have a systemic view? Should we model the system to figure out the small steps that can contribute to change? Cf Ian Gibson's Sydney Symposium. Ken Kay says he knows what needs to be done. 4 Cs.
Ros Sutherland
Reference George Auckland, Some discussion about this on the ITTE Mailing list (see http://itte.org.uk/) and of course CAS is addressing this in more specific ways (see http://www.computingatschool.org.uk/)
Group discussion recorded by Anne Jones: Open University
Richard Noss, Presumably this means we should NOT be obsessed with creationism, but instead with evolution?
Neil Selwyn, Just read Net Delusion: that's a good start
Return to Sin City? Living and Learning with Digital Technology Jean Underwood (notes taken during her lecture) Children are obese because they are playing with computers more and not exercising enough?. BBC news Jean Underwood asks, "Are researchers asking the right questions?". A key finding from the Test Bed project (Somekh et al. 2003-2007). After the technology was introduced results fell markedly in schools in disadvantaged areas but after three or four years they were above the national average. Longitudinal studies are very important. Treasure Island? We are now a risk averse society and do not allow children to grow up. Age differences and cultural differences in childrens computer use. Difference between biological and chronological age is a bigger worry. Hazard, risk, harm Illegal music downloading Cyberstalking Identity theft The most vulnerable are the ones who begin puberty earlier than their peers. Because you begin to show off and start smoking early…. We have puberty starting earlier than cognitive development. Nintendo thumb- carpel tunnel injury and repetitive strain injury The lies we tell and what they say about us; using behavioural characteristics in Social Networking uses Communicators..broadcasters are about promoting lies about themselves… Conclusions We need to accept that one size does not fit all. Treating all children the same is not necessarily giving them equal life chances. What does this mean? Risk is either knowable and therefore learnable, and unknowable and difficult to prepare for- you must give children a chance to take risks…use social networking but discuss the risks and give them risk intelligent… We need to discuss risks in a safe environments…. The World is much more complex than we thought… and what we do is there for life… EU are about does the technology work? We need to look at the round from the perspective of different subject areas…
Jean Underwood
Ros Sutherland
A narrative of hope:
People in CAL do get 'social justice' but this does not come out in the research narrative which has a very instrumentsalist approach.


text:
Illinois Public Media News
In-depth reporting from WILL, NPR, the Associated Press, and other sources
Contact WILL News at firstname.lastname@example.com
February 17, 2014
(Ed Jones/AFP/Getty Images)
February 17, 2014
U.N. Report Details North Korea's 'Crimes Against Humanity'
(Sue Ogrocki/AP)
February 17, 2014
A Push To Boost Computer Science Learning, Even At An Early Age
Page 474 of 1155 pages ‹ First < 472 473 474 475 476 > Last ›
WILL Newscast audio
NPR News
'Like A God,' Google A.I. Beats Human Champ Of Notoriously Complex 'Go' Game
Chinese Student's Commencement Speech In U.S. Isn't Going Over Well In China
'Peace Is A Choice,' Trump Says During Appearance With Palestinian Leader
Poll Shows Increased Support For NATO On Both Sides Of The Atlantic
He Called Himself 'One Lucky Bastard': Sir Roger Moore Dies At 89
Manchester Concert Bombing: What We Know Tuesday
Dina Merrill, Actress, Heiress And Philanthropist, Dies At 93
British Police Confirm 22 People Dead After Explosion At Manchester Arena
U.S.-Turkey Dispute Over Washington Protest Heats Up
Ethics Agency Rejects White House Move To Block Ethics Waiver Disclosures
More NPR News
WILL Highlights
A short film series examining the severe underrepresentation of African-Americans in the sciences.
Classic Mornings
Get more out of your classical music experience and check out Vic Di Geronimo's blog.
The 21st
21st century radio for the 21st state. Weekdays at 11 am on WILL-AM 580.


text:
What will be the role of I-123 MIBG in improving the outcome of medically treated heart failure patients?
- First Online:
DOI: 10.1007/s12350-012-9612-z
- Cite this article as:
- Waqar, F., Dunlap, S.H. & Gerson, M.C. J. Nucl. Cardiol. (2012) 19: 1198. doi:10.1007/s12350-012-9612-z
- Citations
- 927 Downloads
Heart failure (HF) remains the most common cause for hospital admissions in the Medicare age population.1 In recent decades, major advances in medical treatment of HF patients have resulted in longer survival and improved quality of life. Randomized clinical trials have documented that beta-adrenergic blockers (β-blockers), angiotensin-converting enzyme inhibitors (ACE-inhibitors), angiotensin receptor blockers (ARBs), and aldosterone inhibitors have provided improved outcomes for HF patients. Although widely used, these medications have frequently not been used in the doses validated in large clinical trials. This likely reflects concerns about using the full doses of β-blockers in patients with baseline bradycardia and/or using increasing doses of β-blockers, ACE-inhibitors, or ARBs in patients with low baseline systolic blood pressure. Maximum benefit of pharmacologic therapy is limited by inadequate data for drug selection for individual HF patients and inadequate data documenting the optimal therapeutic target for blood pressure and heart rate.
Excessive activity of the sympathetic nervous system is a major contributor to HF progression, by increasing cardiac work, promoting myocardial fibrosis, and causing down-regulation of post-synaptic adrenergic receptors.2 The impact of the sympathetic nervous system in HF patients can be assessed non-invasively by imaging cardiac neuronal uptake and retention of the norepinephrine congener, I-123 metaiodobenzylguanidine (I-123 MIBG). A growing literature addresses the potential role of I-123 MIBG for identifying HF patients at high risk for sudden cardiac death, in whom implantation of a cardioverter-defibrillator may be life-saving.3 Relatively little attention has been focused on the potential role of I-123 MIBG in guiding medical therapy of HF and avoidance of HF progression. Therefore, this review focuses on the question of whether sympathetic cardiac neural imaging with I-123 MIBG has the potential to guide medical therapy of properly selected patients with advanced HF, thereby improving symptoms and outcome.
Target Doses of β-Blockers
Treatment with β-blockers has been shown to reduce cardiac work, up-regulate post-synaptic adrenergic receptors,4 and with carvedilol, for example, reduce proliferation, possibly through antioxidant properties.5 β-blockers reduce the risk of death in patients with chronic HF (CHF).6-9 They are a mainstay of HF management for patients with stages B, C, or D HF. According to the ACC/AHA 2005 guideline update for the diagnosis and management of chronic HF, there are few contraindications to their use.10 More than 20 placebo-controlled trials recruiting over 20,000 patients have demonstrated the benefit of long-term β-blockers in improving symptoms and quality of life in HF patients as well as reducing mortality and the frequency of hospitalization.
Initiation, target and mean doses of various β-blockers in major trials
Study (investigation drug)
Initiation dose
Target dose
Mean dose (mg/day)
CIBIS I (bisoprolol)11
1.25 mg daily
5 mg daily
US CHFS (carvedilol)6
6.25 mg BID
25-50 mg BID
CIBIS II (bisoprolol)7
1.25 mg daily
10 mg daily
MERIT-HF (metoprolol CR/XL)8
12.5-25 mg daily
200 mg daily
MDC (metoprolol)12
5 mg BID
75 mg BID
CAPRICORN (carvedilol)13
6.25 mg BID
25 mg BID
COPERNICUS (carvedilol)14
3.125 mg BID
25 mg BID
Target Doses of ACE-Inhibitors and Angiotensin Receptor Blockers
Pharmacologic inhibition of the renin-angiotensin system can be achieved via inhibition of conversion of angiotensin I to angiotensin II (ACE-inhibitors) or blockade of angiotensin receptors (ARBs). A meta-analysis of randomized, placebo-controlled trials, assessing over 7,000 patients with varying degrees of left ventricular (LV) dysfunction, showed improvement in cardiovascular outcome and mortality with the use of ACE-inhibitors.16 However, patients with low blood pressure (<90 mm Hg systolic) and/or impaired renal function (serum creatinine >2.5 mg/mL) were commonly excluded from these studies.17-22
Initiation, target and mean doses of various ACE-inhibitors and ARBs in major trials
Study (investigation drug)
Initiation dose
Target dose
Mean dose (mg/day)
SAVE (captopril)23
12.5 mg TID
50 mg TID
CONSENSUS (enalapril)22
2.5 mg daily
40 mg daily
SOLVD Prevention (enalapril)24
2.5 mg daily
20 mg daily
SOLVD Treatment (enalapril)21
2.5 mg daily
20 mg daily
AIRE (ramipril)25
2.5 mg BID
5 mg BID
CHARM (candesartan)26
4 mg daily
32 mg daily
From these and other studies, it is apparent that β-blockers, ACE-inhibitors, and ARBs have provided substantial benefits for HF patients in clinical trials. It is not clear that the full benefits of these agents are provided when they are used in reduced doses compared to the doses used in the major clinical trials. In a study of HF subjects treated in an outpatient setting, Peters-Klimm et al34 found that 75% of patients received β-blockers and 80% received an ACE-inhibitor or ARB. Nevertheless, adherence to guideline recommendations for target therapeutic dose was only accomplished in 8% of patients for β-blockers and 16% for an ACE-inhibitor or ARB. Even with adjustment for contraindications for drug therapy, including chronic obstructive lung disease, hypotension, hyperkalemia, and renal dysfunction, only 46% of HF patients received β-blockers and 49% received ACE-inhibitors or ARBs in the targeted doses. Thus, inadequate HF drug dosing may be a common problem faced when trying to optimize HF therapy. This suggests a potentially important role for testing that could provide a metric to determine which drug is the most important to maximize in the patient with low baseline systolic blood pressure and what level of blood pressure lowering provides benefit, whereas further blood pressure lowering may be detrimental. Imaging the response of cardiac sympathetic nerve function to therapy may provide this type of metric.
I-123 MIBG Uptake in HF Patients Reflects Cardiac Sympathetic Nerve Activity and Improves Following Treatment with β-Blockers, ACE-Inhibitors, and Aldosterone Inhibitors
Background of I-123 MIBG-Based Imaging
Sustained hyperactivity of the cardiac sympathetic nervous system observed in HF is a consequence of increased central sympathetic outflow, altered neuronal norepinephrine (NE) reuptake, and facilitation of cardiovascular response to sympathetic stimulation by angiotensin II. Myocardial beta-adrenoceptor density is reduced in patients with HF. With progressive HF, there is reduced uptake of NE into presynaptic cardiac nerve storage vesicles via the NE uptake-1 transporter. Chronic over-exposure of post-synaptic beta-adrenergic receptors on the cardiomyocyte to NE in the synaptic cleft results in beta-receptor desensitization and eventual catabolism and loss of beta-receptors.
I-123 MIBG is the most widely used imaging agent for studying cardiac sympathetic hyperactivity. Uptake of I-123 MIBG into presynaptic sympathetic neurons occurs through the same uptake-1 transporter mechanism responsible for the reuptake of NE. Reduced function of the uptake-1 mechanism may lead to abnormally high levels of catecholamine in the synaptic cleft.
Imaging of Cardiac Adrenergic Activity as Predictor of Outcome
Many studies have demonstrated that impaired cardiac adrenergic innervation assessed by I-123 MIBG imaging is strongly related to adverse cardiac events and mortality in patients with HF.36 The AdreView Myocardial Imaging for Risk Evaluation in HF (ADMIRE-HF) trial37 evaluated 961 HF patients (NYHA class II-III, LVEF < 35), using a prospectively selected HMR of 1.6 to separate low- from high-risk patients. The combined adverse event rate was found to be 15% for patients with an HMR ≥ 1.6 and 37% for HMR < 1.6 (hazard ratio [HR] 0.40, P < .001). A late HMR ≥ 1.6 was independently associated with a reduced risk for HF progression (HR 0.49, P = .002), cardiac death (HR 0.14, P = .006), and potentially life-threatening arrhythmic events (HR 0.37, P = 0.02).
Cardiac I-123 MIBG Imaging in Predicting Effect of Medical Therapy
As clinical status and LV function improve in response to β-blockers, ACE-inhibitors, ARBs, and/or aldosterone antagonists, there is a parallel improvement in cardiac sympathetic nerve function as assessed by I-123 MIBG. In 30 NYHA class II or III HF patients treated with 16 ± 4 mg/day of carvedilol for 12 ± 1 months, Kasama et al.38 noted that an improvement from baseline in B-type natriuretic peptide from 270 ± 249 to 148 ± 125 (P = .002) and in LVEF from 33 ± 6 to 39 ± 6 (P = .003) was paralleled by an improvement in late I-123 MIBG HMR from 1.66 ± 0.16 to 1.88 ± 0.23 (P < .001). Similar concordant improvement in cardiac sympathetic nerve function with improvement in clinical status and/or LVEF has also been observed in response to treatment with metoprolol,39 carvedilol,40,41 bisoprolol,42 enalapril,43 candesartan,44 and spironolactone.45
Improvement in LVEF in response to β-blocker therapy has been documented in HF patients with a broad range of baseline sympathetic neural impairment.46 For an individual HF patient, the cardiac sympathetic neural response to drug intervention may provide insight into the amount of benefit provided compared to other HF treatments. Neural imaging studies may have a role in differentiating patients likely to benefit from medical therapy from those that are likely to show poor long-term response and thus might be better candidates for non-medical therapy (e.g., device therapy and cardiac transplantation). Furthermore, neural imaging may help identify patients in whom aggressively increasing medical therapy, despite mild hypotension or other mild side effects, might produce a more favorable clinical outcome.
What is the Lower Limit of Systemic Blood Pressure That Should be Targeted with β-Blockers, ACE-Inhibitors, and angiotensin receptor blockers?
The majority of HF trials have used arbitrary lower limits of systemic blood pressure (e.g., 85-100 mm Hg) to determine the target therapeutic dose, without clear evidence of poorer outcome at lower systolic blood pressures. On the other hand, evidence of worsened outcome with or without treatment in HF patients with low systolic blood pressure has been well established.47
Because adrenergic stimulation plays an important role in maintaining both blood pressure and cardiac contractility in patients with impaired LV systolic function, the administration of adrenergic blocking drugs can cause both hypotension and worsening HF. The risk of these adverse circulatory reactions is most marked in patients with the lowest BP or most advanced disease before treatment.48 Such patients have generally responded poorly to treatment and have frequently been excluded from participation in clinical studies using beta-blocking drugs.7,8 An important exception is the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study9,14 that evaluated the effects of carvedilol in patients with severe HF, including those with a very low SBP (85-100 mm Hg). This study demonstrated a reduction in the risk of death (P = .0014) and combined risk of death or hospitalization (P < .001) in these patients using carvedilol, but did not explore whether pretreatment BP influenced the presence or magnitude of these benefits. A follow-up study by Rouleau et al.47 confirmed that progressively lower systolic blood pressure is associated with progressively worse outcomes. Nevertheless, β-blocker therapy improved outcome significantly for patients across the range of baseline systolic blood pressures. The benefits of beta-blockade appeared to be the greatest in the patients with chronic stable HF with the lowest baseline blood pressure. Baseline systolic BP does not appear to be a determinant of the response to ACE-inhibitors16 or ARB's in large-scale trials. In the CHARM study, similar improvement in outcome with low, medium, and high doses of candesartan was observed regardless of baseline systolic blood pressure.26
By Assessing Impact on Sympathetic Nervous System Function as Assessed by I-123 MIBG Imaging, Can an Optimal Target Systemic Blood Pressure be Identified for β-Blocker, ACE-inhibitor, and Aldosterone Antagonist Therapies?
The benefits of therapies that ameliorate the effects of neurohormonal imbalance in the failing heart are well established. For patients who respond well to HF therapy with full therapeutic doses of β-blockers, ACE-inhibitors or ARBs, and aldosterone antagonists, there is currently no potential advantage to an addition of neural imaging to monitor the response to proven therapy. Yet, it is clear that a significant proportion of HF patients are not receiving full, proven-to-be-effective doses of these HF drugs due to concerns about resultant hypotension. Although it is known that low baseline systolic blood pressure portends an adverse prognosis in HF patients, it is not clear to what extent doses of proven HF drugs should be up-titrated to improve prognosis in these patients. In the patient with a baseline systolic blood pressure of 95 mm Hg, does the outcome improve or worsen when a β-blocker, ACE-inhibitor, or ARB is increased and the blood pressure falls to 85 mm Hg? The symptomatic response of the patient may determine the treatment endpoint in some patients, but in patients who remain asymptomatic or minimally symptomatic, the blood pressure endpoint on treatment is often undefined. Does cardiac sympathetic innervation and activity improve or worsen as HF drug therapy is maximized to relatively low (e.g., <90 mm Hg) systolic blood pressure levels? By identifying the target blood pressure that maximizes sympathetic nerve function, can HF outcome in response to medical therapy be optimized?
Alternative Methods for Assessment of Cardiac Sympathetic Neuronal Function in HF Patients
Elevated plasma norepinephrine levels are associated with increased sympathetic nervous system function and unfavorable outcomes in HF patients.49 Serial measurements might provide a method for assessing the response of the sympathetic nervous system to selection and dosing of HF medications, but have not entered into wide clinical use. Plasma norepinephrine levels are altered by a wide variety of physical and emotional stimuli that affect norepinephrine release, as well as changes in cardiac output and regional blood flow that vary the rate of removal of norepinephrine from the plasma.50 Heart rate variability is an indirect method for assessing cardiac sympathetic nerve activity and has been associated with HF outcomes in several studies.51 Reduced heart rate variability reflects sympathetic autonomic activity, but is also influenced by parasympathetic tone, chemoreceptor function, respiratory rate and tidal volume, mechanical factors (e.g., stretch of the atria from changes in cardiac filling and thoracic pressure), and level of physical activity. These multiple variables affecting heart rate variability, as well as the technical limitations in heart rate variability measurement, limit its potential to detect changes in cardiac sympathetic activity that may alter response to adjustment of medical therapy.52,53 In studies directly comparing heart rate variability to I-123 MIBG imaging, I-123 MIBG imaging was predictive of all-cause mortality54 and for either cardiac death or hospitalization for HF,55 whereas heart rate variability was not.
Cardiopulmonary exercise testing, with measurement of maximum oxygen consumption (VO2 max), and the 6-minute walk do not focus specifically on cardiac sympathetic neuronal activity, but are well-validated and accepted procedures for measuring the functional response to HF treatment. These tests are important comparators for future studies to assess a potential role of serial neuronal imaging in the assessment of clinical response to modifications in HF therapy.
What is Needed to Validate a Meaningful Role of Cardiac Neuronal Imaging in the Selection of Medical Therapy and Optimal Therapeutic Doses in HF Patients?
- (1)
It must be determined if the reproducibility of the I-123 MIBG HMR measurement is adequate to accurately identify a significant change in response to a selection of medication or dose adjustment. The HMR is highly reproducible in normal subjects,56 however, HF subjects have low I-123 MIBG cardiac count statistics and HMR reproducibility is not well established. Nevertheless, the studies cited earlier show an increase in HMR in response to known effective HF drugs, indicating that improvement in neural function by HMR is measureable with I-123 MIBG. Whether these demonstrable changes in HMR reported in populations of HF patients will be paralleled by demonstrable changes in HMR in response drug dose changes in individual HF patients remains to be proven.
- (2)
The hypothesis requires testing that I-123 MIBG can identify differences in neuronal function in HF patients treated to moderate treatment goals (e.g., systolic blood pressure 95-105 mm Hg with no symptoms) versus aggressive goals (e.g., systolic blood pressure 85-95 mm Hg and/or mild symptoms).
- (3)
The hypothesis also requires testing that patients with LVEF ≤ 35% and NYHA class II or III HF randomized to I-123 MIBG guided medical treatment have improved survival compared to patients treated by guidelines-based conventional HF treatment alone.
- (4)
Similarly, testing is needed to determine if severe HF patients with a poor versus favorable neuronal response to maximal medical therapy have a more favorable outcome with left ventricular assist devices compared to continued medical therapy alone.
With the growing burden of HF in our society, improving outcomes by optimizing HF medical therapy is a priority, and measuring the response of the cardiac sympathetic nervous system to treatment may help provide answers to difficult therapeutic questions.


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Cats Claw Benefits
Uncaria tomentosa
Griffe du Chat, Liane du Pérou, Life-giving Vine of Peru, Samento, Uña de Gato, Uncaria guianensis, Uncaria tomentosa.
Mostly Peru; Pan Amazon Basin in general.
Bark, roots and Leaf.
Because the reputation of Cats Claw has spread far and wide there are a great many different medicinal qualities attributed to it. Numerous different Amazonian tribes use this plant for a number of varied complaints. This is why the Cats Claw vine has generated a reputation as a panacea over a period of around 2,000 years. Listed below are some of the traditional benefits the bark of the Cat's Claw has been given by the tribes of native Amazonian Indians.
The Asháninka Indians use the Cats Claw bark for these illnesses and bodily complaints: a kidney cleanser, to cure deep wounds, help alleviate arthritis, asthma, inflammations of the urinary tract, rheumatism, inflammation in general, gastric ulcers and recovery from child birth.
In Colombia some Indian tribes use the Cats Claw as a remedy for gonorrhoea and dysentery.
Where as in Surinam the Cats Claw is used to stop intestinal infections, dysentery and for the treatment of wounds.
Interestingly there are also a number of tribes who use the Cats Claw as a female contraceptive. A very strong Cats Claw root concoction is prepared to be taken during the menstrual cycle for three consecutive months. This treatment is apparently used to halt the menstrual cycle for three to four years.
In general, all of the Amazonian tribes mentioned above, consider the Cats Claw to be a tonic that can be used to bring anyone back to health. Even if suffering from acute illnesses the Cats Claw is thought to be able to rebalance the immune system so that it can better fight any sickness.
There have been several studies completed that have looked into the alkaloid content of Cats Claw bark to see how it interacts with the body. Extensive research is ongoing since this particular plant holds so many varying phytochemicals that have possible interactions with human physiology.
The studies that have been completed show that for joint pain, specific arthritis of the knees/legs and rheumatoid arthritis, Cats Claw treatment might help individuals cope with pain and also enabling more fluid movement. There is also some evidence that Cats Claw could have antiviral properties, helps bolster the immune system and also helps with bowel and colon complaints.
The bark of the Uncaria tomentosa is considered to be the most medicinally useful. Both Leaves and roots have been proven to hold significant phytochemical content but not in such concentration as is found in the bark.
Traditionally the bark of Cats Claw is made into a tea or powder to be consumed over a given period depending on illness.
For the Asháninka Indians Uncaria tomentosa is the totality of their culture. It is depended on so much that traditionally every adult from this tribe carries around Cats Claw bark in a little woven pouch. It is not just the plant they harbour as sacred but what the plant has done for their ancestors. The Asháninka are one Amazonian tribe that live very deep in the jungle, far from habitation and other tribes. It is thought that the Asháninka were the tribe that taught all other Amazonian Indians in the area about the qualities of this amazing plant. Noted by the Polish missionary Father Edmund Szeliga, the Uncaria tomentosa vine was very holy to the Incan people as it is now today to the Asháninka. The latter consider the plant a god incarnate called 'kug – kukjagui' and the father of all other forest gods. The high reverence paid to the Cats Claw vine by the Asháninka shows its potent quality as all other medicinal plants are given a lower status. Even for the Incan royal families the Cats Claw was considered only fit for those of royal blood. Not only are the roots, bark and leaf made into concoctions but the bendy vine is also used to make a variety of baskets and rattan furniture. The lower parts of the thick base of the vine are whittled into carvings of other gods showing that the Asháninka regard even the wood as having sacred qualities.
The legend concerning Cats Claw that comes from the Asháninka tells of how Tasurinchi, the first of their people, came to know of the healing qualities of the vine. In the tale Tasurinchi lives in seclusion since there were no other people to help him. He does all the hunting, domestic chores as well as make his home secure which makes his life heavy and unbearable. One day Tasurinchi is rushing through the jungle and meets one by one a puma, a capybara and a tapir. To each he complains of having an ailment; a stomach ache, headache and a deeply cut hand respectively. Each of the animals tells him to use the kug – kukjagui in a different manner to heal his body. Tasurinchi's life is suddenly transformed from the medicinal Cats Claw properties the animals had shown him. From this moment on the knowledge of the Cats Claw was given to the Asháninka Indians to use for a great many things in their lives. Even today the Cats Claw is of major economic importance to the Asháninka Indians.
Cats Claw has many phytochemical elements that consist of oxidole alkaloids, quinovic acid glycosides, antioxidant chemicals, plant sterols and carboxyl alkyl esters. All of these are thought to have, in varying degrees, an action that can be attributed to the many benefits that Cats Claw is attributed with. Listed below are the known chemical elements of Cats Claw.
Ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, loganic acid, lyaloside, mitraphylline, oleanolic acid, palmitoleic acid, procyanidins, pteropodine, quinovic acid glycosides, rhynchophylline, rutin, sitosterols, speciophylline, stigmasterol, strictosidines, uncarine A thru F, and vaccenic acid.
In some individuals Cat's Claw has been known to thin blood. If taken in large quantities (3/4 grams in one serving) Cat's Claw can cause stomach upset because of the large number of tannins in the bark. It is recommended to increase dose in increments to lessen the symptoms of detoxification. It is not recommended to take Cat's Claw if you have scheduled surgery.


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