text:
Open-Xchange: More Components Released under GPL
Following the server component, groupware specialist Open-Xchange has now released administrative and installation tools under thee GPLv2.
The GPL-licensed components are referred to as the Open-Xchange Community Edition which offers email, to-do, contact and task management features. The Ajax front-end, which acts as a browser component is still released under a Creative Commons License (Attribution-NonCommercial-ShareAlike 2.5).
The new license gives corporations the ability to deploy Open-Xchange. The Open-Xchange company earns money on system maintenance, support and Microsoft Outlook integration. The latter is a popular feature of the Open-Xchange solution. The Community Edition can be downloaded.
Issue 199/2017
Buy this issue as a PDF
Red Hat Announces OpenShift.io
Red Hat takes its IDE online.
Microsoft Bakes Linux into Windows Server
Microsoft is slowly becoming a Linux vendor.
Fearless Coyote, Linux Kernel 4.11 is Out
The new kernel makes swap implementation more scalable, which will help cloud providers.
Docker Appoints Steve Singh CEO
The new CEO comes from a very strong SaaS background.
Docker Announces Linux Kit and Moby Project
Both projects help organizations build their own containerized systems.
Ubuntu Returns to Gnome as Its Mobile Plans Shatter
Mark Shuttleworth has resumed the position of CEO of Canonical.
Microsoft is Shutting Down CodePlex
Microsoft's open source code hosting platform CodePlex will come to an end after a more than 10-year stint.
Fedora 26 Alpha Released
Comes with Gnome 3.24
Old Linux Kernel Bug Discovered
The bug was introduced back in 2009 and has been lurking around all this time.
OpenSSH 7.5 Released
The new release deprecates the sshd_config UsePrivilegeSeparation option.


text:
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subset: commoncrawl


text:
Bathroom exhaust question
Does it make sense to exhaust a bathroom exhaust fan through the attic and to the vent in the gable? It would seem to me that overtime the moisture would eventually rot the wood, or cause mold. That plus the run from the floor of the attic to the vent is about 4 feet up.
As long as you don't lesson the air flow of the gable vent and restrict it's intended use I don't see a problem. Getting the moisture out of the building is the key. Unless the outside is dead air space the moisture should evaporate fine.
This generally means you cannot vent a bath exhaust into an attic and expect it to passively vent via attic vents.
Under most circumstances, MinConst is wrong and in violation of most building codes....
It's not hard to take it through the roof, then you don't have to worry about condensation up there.
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text:
Finally something to cheer about:
Please note that search results will vary w.r.t time and may not be same all the time. Google's search algorithm sorts the results based on numerous criteria and is a highly dynamic phenomenon. Whatever I'm writing is based on the inputs available and validated while writing this post and over a period of time things may change)
For me this is an assurance for the quality of the content in my post and will inspire me to write much better articles. It's an assurance that what I've written has been identified as highly useful for rest of the world. This boosts my spirits and encourages me to write more and more quality articles.
Your encouragement keeps me writing. Thanks. Just sharing my joy.
Sunday, December 03, 2006
On top of the world
Finally something to cheer about:
1 comments :
- Shrinidhi Hande said...
Pls ignore this post for the time being. After updating my blog with new post the search results are not showing my blog as it used to. Trying to figure out why..
- Monday, December 04, 2006 9:40:00 AM


text:
Business FAQs:Frequently asked questions
If you are a business professional interested in working with HealthRight, use this page to find answers to business FAQs questions about our unique iCare program.
What business services do you offer?
With HealthRight's comprehensive iCare program, we can provide your employees or members with access to a wide array of health solutions that can improve their health, increase productivity, and cut costs for them and your organization. We partner with companies to find the right combinations of services, including but not limited to: on-demand doctor visits, unlimited access to licensed nurses, plus discounts on prescriptions, dental care, lab work, and more. Our flexible approach makes it possible for us to help almost any business or organization. Whether you want to supplement your existing benefits package or add HealthRight as a "thank you" to your employees or members, we have a program that can meet your needs.
How can you save my company money?
Using iCare from HealthRight can help save your company or organization money in several ways. The most direct way is by offering fast, convenient, dependable, and affordable health care solutions to your employees or members. By being able to access a doctor or nurse remotely to deal with their health concerns, your staff won't have to take as much time away from the office. Being able to save money on a wide array of health solutions also leads to healthier employees, which thereby increases productivity and reduces lost work hours. In the long term, offering this service to your employees can increase job satisfaction and retention, reducing the need to hire and train new staff.
How do I get HealthRight for my business or organization?
To find out about our iCare services and how to get started, the fastest way is to contact our Business Relations department. You can call us at 888-738-5574 or email us at email@example.com. A service specialist will answer your questions, review our programs, and help you initiate the process as soon as possible.
Why does HealthRight work so well for businesses and organizations?
Our unique approach goes beyond merely contacting potential members and signing them up for our programs. HealthRight is dedicated to forming personal and enduring relationships with everyone whom we serve. We utilize a unique approach that reaches, educates, profiles, matches, engages, and retains our members with a customized health car experience. Our members know that we care about their health and well-being … and by extension … that you do, too.
What types of businesses do you work with?
We work with a wide range of businesses and organizations from all types of industries. We provide our HealthRight iCare services to large and small companies, member organizations, and non-profits alike. Because we implement a unique and flexible approach to providing the solutions we offer, it is possible for us to help almost any type of business or organization.
What types of businesses do you work with?
We work with a wide range of businesses and organizations from all types of industries. We provide our HealthRight iCare services to large and small companies, member organizations, and non-profits alike. Because we implement a unique and flexible approach to providing the solutions we offer, it is possible for us to help almost any type of business or organization.
What types of health solutions do you offer?
Through HealthRight iCare, your employees or members can access a comprehensive collection of health solutions. With the free membership model, they can get access to:
- On-demand tele-consults with board-certified physicians
- Unlimited, 24/7 consults with licensed nurses – always for free
- Savings of up to 60% or more on prescriptions, lab tests, dental care & more
- Join a wellness program for weight management, vitamin recommendations, and more
Your employees and members can also upgrade to a paid subscription (either iHealth or iHealth Plus), which expands their savings, provides access to a larger network of doctors and also provides a Medical Bill Advocacy program to help them save more money.
I'm a medical professional. Why should I join HealthRight?
HealthRight is committed to being the most trusted provider of web-based, personalized health solutions. Our proven platform enables concierge care for the consumer by accelerating their engagement with licensed U.S. healthcare providers and utilizing our innovative technologies for improved health awareness and service experience. As a HealthRight provider, you will have the ability to set your own hours, be compensated for the services you provide, and know that you are helping patients in need. To join our clinical network, please contact our Provider Relations Department at 888-738-5574 or email us at firstname.lastname@example.com
How do you know if a HealthRight member is from my business or organization?
Working with HealthRight means having a healthcare partner. Our implementation teams work side by side with your organization to ensure that member eligibility occurs seamlessly and accurately, that our HealthRight iCare services are communicated effectively, and that your members or employees experience excellent service every day. Because of this collaborative approach, we are able to easily identify participants in our programs based on their unique profiles.
Didn't get your business FAQs answered?
Call us now or send an email.
One of our Business Relations Specialists will be happy to answer your business FAQs as soon as possible.


text:
The Best Day of my Life
I woke up at 8:00 AM Saturday morning from the sound of the door slamming downstairs. I was tired from waking up the night before, but too awake to get back to sleep. So I moseyed on down the stairs in my ratty t-shirt and gray sweatpants to meet my Aunt.
"Good morning, Jenn," my Aunt Amy groaned in an exhausted voice from the kitchen. I observed her. She was still dressed in her doctor's lab coat. Her hair was ruffled and her name tag was upside down. She dragged her feet as she laid the morning mail on the kitchen counter and then went to the pantry for a coffee pack.
"Wait, Aunt Amy," I said, hurrying over to the pantry and taking her hand, "let me make you some coffee."
"Oh, thank you," she gasped placing her hand on her forehead. "I have such a migraine." She plopped down on a stool in front of the counter and rested on her elbow. Her head soon fell on the granite counter and she was resting. I continued with the coffee and at the same time got her some Advil and a glass of water and laid it by her head. She could take it when she woke up.
After pouring some hot coffee in a mug and setting it next to my sleeping Aunt, I began to open our mail which had arrived unusually early that day. Most were for her, bills and hospital things, but I came across one letter that was, in fact, for me. I slid my finger under the adhesive glue and pulled out a yellow paper. Progress reports already? I complained to myself. I hesitantly unfolded the report and discovered an overall grade of D-. I shook my head.
"How did I get a D-? No way!" I scanned the grades;
A, A+, A, A-, for the first week of school.
A, B-, B, C+, for the second.
D+, Missed Test, Missed Test, Missed Test, for the last.
"Dang it," I muttered.My grades had definitely decreased in the past days I had been thinking about Ben and Martha's disappearance. I knew this to be a fact, because I had noticed it myself but didn't really care. I threw the paper back on the counter and mentally screamed at myself. Then the doorbell rang.
My Aunt's head snapped up an looked around. I groaned.
"Sorry Aunt Amy, the doorbell just rang. Maybe you should go up to your room now, so you could get some real sleep?" I suggested. So she picked herself up without a word and clambered up the stairs. When she was out of sight I went to the sitting room to open the door. I took the metal knob in my hand, twisted it, and pulled the door open.


text: A man and a woman in Casco were injured, after the snowmobile they were riding crashed on a lake. Game Wardens say the pair was riding a snowmobile on Thomas Pond near the man's home Sunday.They hit the shoreline and the snowmobile tipped.The 47-year-old man hit his head on an aluminum boat lift. He suffered a broken neck, broken collarbone and head lacerations.He's now hospitalized in critical condition.A 41-year-old woman from Naples was bruised in the crash. According to two ice fishermen, the man was sitting behind the woman on the snowmobile but was driving. Authorities say the man was summonsed for operating under the influence and refusing to submit to a blood-alcohol test.


text:
IK Multimedia Amplitube 3 - DiscontinuedAmpliTube 3 by IK Multimedia contains over 160 pieces of gear, more than double the amount of other packages, including models from the most sought-after vintage collections and modern-day workhorses. You'll get 51 individual stompboxes and effects, 31 amplifier, preamp & power sections, 46 speake Learn More£148.99 £124.16 (ex. vat)
Contact us to discuss sourcing this or similar products
Softube Metal Amp Room Plug-InSoftube Metal Amp Room was designed to bring you the most brutal, evil and aggressive guitar sound that is possible to squeeze out of your DAW. Run it in mono for a tight and focused sound, or let it take up your entire stereo width by the use of two panned microphones. Learn More£93.00 £77.50 (ex. vat)
IK Multimedia Total Guitar & Bass BundleIK Multimedia Total Guitar & Bass Bundle Learn More£372.00 £310.00 (ex. vat)


text:
MARKET PULSE-Goodrich Petroleum, Blackhawk Network, Biolase, Yandex
(For more market insights, including options activity, click on ; for the Day Ahead newsletter link.reuters.com/mex49s; for the Morning News Call newsletter, link.reuters.com/nex49s) U.S. stocks edged higher in volatile trading on Thursday, as a strong read on manufacturing offset weak results from Wal-Mart and geopolitical and economic uncertainty around the world. The Dow Jones industrial average was up 0.54 percent at 16,127.54, the S&P 500 was up 0.51 percent at 1,838.06 and the Nasdaq Composite was up 0.38 percent at 4,253.888.
** FACEBOOK INC, $67.18, -1.29 pct
** BLACKBERRY LTD, $9.52, +5.66 pct
Facebook's purchase of fast-growing mobile-messaging startup WhatsApp for $19 billion stunned the markets but analysts said the deal made strategic sense as it will solidify the social network's position as a leader in mobile.
For a graphic on price paid per user, (link.reuters.com/mej96v)
The stunning bid pushed up shares of BlackBerry Ltd as investors placed bets that the smartphone maker's own messaging platform has been undervalued.
** WAL-MART STORES INC, $73.52, -1.78 pct Continued...


text: Audio offers a variety of options for your next event. Our team will work closely with you to figure out dining, décor and technology to create your next event. If you are interesting in hosting your event at Audio, please fill out the form below and our event manager will be in touch shorty. To reach our events director directly, please contact Kyla Naegle at 415-741-0447 / email@example.com


text:
Elan Chainsaw Ski - $299.98
As the storm takes aim on your home range, you dream of hucking cliffs, throwing smooth 3s, and destroying pillows. But since the landings are best in the backcountry, let the Elan Chainsaw Ski get you there and keep you stomping everything in sight. With this fat and deliciously curvy board under your foot you can't escape that feeling of floating, that feeling that every flake fell for you, and that it's time to send that cliff you've been eying for months. Though lightweight and flexible for skinning and backcountry butters, this reinforced twintip keeps you solid while speeding out of a landing or while encountering variable snow between storms. - $299.98


text:
The final hours of build up to the most eagerly but most nervously anticipated sporting event in decades began with tear gas, rubber bullets and stun grenades fired down the streets of Sao Paulo, as the promised and much feared protests materialised, where there was hope that they wouldn't.
At least 200 protesters clashed with riot police as they sought to block a road five miles from the Arena Corinthians, and sabotage an event that has cost billions of pounds of public money in a nation fraught with poverty and inequality.
At least one person was detained by police, and six people injured, three of them journalists.
In the arena itself, the scenes in the stands were more enchanting than the short opening ceremony, as the 65,000 seats turned slowly into a sea of yellow, for the first World Cup in Brazil in 64 years.
World Cup 2014: Protests before opening ceremony
World Cup 2014: Protests before opening ceremony
1/10 World Cup 2014 protests
A masked man throws a stone towards riot policemen in Sao Paulo, Brazil, 12 June, 2014, hours before the first World Cup match was to be played.
AP Photo/Rodrigo Abd
2/10 World Cup 2014 protests
Masked anti-World Cup protesters rip apart a Brazilian national team soccer jersey during a demonstration, in downtown Rio de Janeiro
AP Photo/Leo Correa
3/10 World Cup 2014 protests
Masked men work to uproot a street sign to add to a makeshift barricade during a protest by people demanding better public services and against the money spent on the World Cup in Sao Paulo
AP Photo/Rodrigo Abd
4/10 World Cup 2014 protests
A protester is detained by police during a demonstration by people demanding better public services and against the money spent on the World Cup
5/10 World Cup 2014 protests
The protester is restrained on the ground. Brazilian police clashed with anti-World Cup protesters trying to block part of the main highway leading to the stadium that hosts the opening match of the tournament
AP Photo/Nelson Antoine
6/10 World Cup 2014 protests
A protester holds a sign that reads in Portuguese "There won't be a Cup!" during a demonstration demanding better public services in Sao Paulo
AP Photo/Nelson Antoine
7/10 World Cup 2014 protests
A masked protester returns a tear gas canister to riot police during a demonstration by people demanding better public services and against the money spent on the World Cup soccer tournament in Sao Paulo
AP Photo/Rodrigo Abd
8/10 World Cup 2014 protests
A protestor argues with police during the demonstration in Sao Paulo
AP Photo/Rodrigo Abd
9/10 World Cup 2014 protests
Passengers await their flights during a partial work slowdown at Rio de Janeiro's Santos Dumont airport on 12 June
REUTERS/Lucas Landau
10/10 World Cup 2014 protests
Construction workers listen to a protest leader speak during their demonstration against the World Cup outside the hotel where the media is staying in Fortaleza, Brazil
AP Photo/Fernando Llano
You can forgive Brazil for keeping its ceremony powder dry. They have the rather larger affair of the Olympics Opening Ceremony to consider in two years time. At 3pm local time, over a luminous polyethylene carpet, dancers dress as lilac teardrops ran in concentric circles around a glowing 'living ball' - which then opened like a Terry's Chocolate Orange to reveal Jennifer Lopez, the rapper Pitbull in worrisomely tight white trousers and the Brazilian pop singer Claudia Leitte, who sang the World Cup theme tune, We Are One.
A total of 660 dancers paid tribute to the country's 'nature and people', but those in the stands were hard pressed to comprehend quite how, as school boys did keepy uppy with balls on ropes, and the usual cast of gymnasts in medieval jester style outfits somersaulted over one another and bounced up and down on trampolines.
If it all felt a little short, it was in no small part because neither the Brazilian President Dilma Rousseff nor Fifa President Sepp Blatter made speeches, fearful of the loud booing that met them at the Confederations Cup last year.
Ms Rousseff has pleased for Brazilians to welcome visitors just as Brazil has been welcomed at other tournaments.
Meanwhile workers at Rio de Janeiro's three airports announced a strike over pay and World Cup bonuses, causing tanks to be dispatched to the international terminal fearful of angry scenes with thousands of passengers likely to be affected.
But the city's metro system was packed with fans in the yellow of Brazil and the red and white of Croatia, after workers called off a strike planned for Thursday that had the potential to seriously damage the opening match.
The influential Homeless Movement, who were planning major protests at all 64 of the tournament's matches have also called off their plans.
Below the 20,000 seat temporary stands, which were just about finished in time, Brazil fans milled about in the concourses like bees in a hive, electrifying stuff. On the pitch, there were men dressed as trees turning in circles, bright humanoid flowers in pink and green, and women in dresses so wide, short and lace-covered they were less meringue, more coconut biscuit. But it is that Brazilian yellow - the colour they only after adopted after the Maracanazo - the disaster of the Maracana - when they lost the 1950 World Cup final wearing blue and white.
And there can be no doubting the most electrifying moment of all - at least in the build up. When living ball was dismantled, the pitch covering rolled away, and the Selecao, as the Brazilian team likes to call itself ran on the pitch, many with their fingers pointed first to the stands and then to the sky, the noise suddenly loud, intense and expectant.
There are protests planned at each of the 64 matches of this year's tournament, which has cost around £7bn, the most expensive World Cup in history. But many, if not most Brazilians are just as intent as the protesters are on enjoying the football - they have certainly paid for it. In Sao Paulo, many residents approached the riot police to offer congratualtions for their zero tolerance tactics.
President Rousseff has defended the money spent on the tournament, citing the infrastructure improvements and lasting legacy it will bring. But many such projects were never started, and some are unfinished now the tournament is under way, not least the Sao Paulo monorail, on which a worker was killed on Tuesday.
The country built twelve new stadiums to host the tournament, all largely from scratch. Previous hosts have had more to begin with, and then staged the tournament in fewer venues.
The build up has also been set against unprecedented levels of scandal and criticism levelled at Fifa, as yet more corruption allegations have emerged. The football has felt a long time in coming. Not before time, it is underway.Reuse content


text:
When I saw the title I thought it would be a good laugh to hear Bob Costas talk to us about guns.
This is a discussion on Chris Costa on shotgun vs. handgun for home defense within the Home (And Away From Home) Defense Discussion forums, part of the Related Topics category; I like the way he makes his case. Agree or not, I believe this is a good example of how to argue your point. That ...
I like the way he makes his case. Agree or not, I believe this is a good example of how to argue your point. That said, I think he's on to something here.
Last edited by CR Williams; April 9th, 2014 at 09:38 PM.
Si vis pacem, para violentus.
When I saw the title I thought it would be a good laugh to hear Bob Costas talk to us about guns.
I would say his home defense weapon is ideal
He does make a good argument. My bedside is a 1911 with an 870 standing by if needed.
House layout and alarms/lights, etc. would determine it for me. It's all about how much time you really have.
Did I mention have a plan and practice...
"Don't shout for help at night, you may wake your neighbors"
G21 with an X300 and Leopold RDS is my night gun. I think he hit the nail on the head. Sometimes I just put a G21 mag in my G30 with its night sights - green front and orange rear - also makes it easy to see the sights, but no light. I keep a surefire by the bed anyway.
"I've noticed that everyone that is pro-abortion has already been born." - Ronald Reagan
"When governments fear the people there is liberty. When the people fear the government there is tyranny." Thomas Jefferson
You are only paranoid until you are right - then you are a visionary.
I don't have kids at home and I don't like lights or cans on my home-defense gun which is also a daily carry gun. My nightstand gun is a 1911 with night-sights. There are long guns including 12 gauge shotguns loaded with #1 buckshot available if needed.
Second Amendment: The difference between politicians and rulers.
U.S. Army, Retired
NRA Benefactor Life Member
I totally agree with his thinking in almost every aspect.
" Blessed is that man, who when facing death, thinks only of his front sight"
-Jeff Cooper
I am not going to walk around clearing my house. They have to come up stairs to the 2nd floor and a 20 ft. hallway to get to me, when the reach the head of the stairs they are in the kill zone. My wife is on the floor, behind the bed dialing 911, I am prone at the bedroom door with my shotgun. I have an alarm system and a dog that barks at noises.
With long guns available, my M&P45 with a TLR-1 has been my home defense firearm of choice. Before that it was an HK USP .45 with a TLR-2. For me to use a long gun for home defense, thing have to gone very, very bad.
Think like a man of action - Act like a man of thought


text:
Paul: Apostle to the Nations, An Introduction
Who was Paul? What did he do? What did he write? Walter F. Taylor Jr. sets out to bring together a wealth of contemporary perspectives in a clear and accessible synthesis, bringing to bear on his subject the best of recent social-scientific and cultural-anthropological thinking on Paul.
- Format Paperback
- Pages 398
- Textbook Survey Texts
- Dimensions 6 x 9
- Publication Date Sep 15, 2012
Part One: Who Was Paul and What Did He Do?
Introduction: Why Study Paul?
1. How Can We Study Paul?
2. What Sources Can We Use to Study Paul?
3. Who Was Paul?
4. What Did Paul Do?
Part Two: What Did Paul Write?
5. First Thessalonians: The End is Near
6. Galatians: Free To Be Children of God
7. First Corinthians: Life in the Body
8. Second Corinthians: Treasure in Clay Jars
9. Romans: God Justifies the Ungodly
10. Philippians: Citizenship in Heaven
11. Philemon: Life in the Christian Family
12. How Did People Develop What Paul Wrote?
Endorsements"Professor Taylor has provided a clearly written and highly informative account of Paul's life, his world, and his letters. The presentation is well organized, comprehensive, and insightful, making the apostle and his work accessible to the reader. The book can be recommended highly for students and others who want a reliable guide to one of the most important figures and collections of New Testament writings at the dawn of Christian origins."
—Arland J. Hultgren
Luther Seminary, St. Paul, Minnesota
"This extremely well-written study combines an effective exposition of Paul's identity with an effective exposition of Paul's seven undisputed letters. Professor Taylor is remarkably sensitive to the Roman imperial context of Paul's ministry and the impact of Paul's Roman chains upon his letters to the Philippians and to Philemon."
—Richard J. Cassidy
Sacred Heart Major Seminary, Detroit, Michigan
ReviewsReview in Interpretation: A Journal of Bible and Theology
Review on Talmindimblogging
Chapter 1


text:
Drogba signed for Shanghai Shenhua from Chelsea this summer and says he is enjoying life there.
"I wanted to experience another culture, another world," he told Le Sport 10.
"This experience is unlike anything I have known, you look around and it is skyscrapers galore – but also not too far away most of the population is farmers.
"Playing in China is very rewarding and I enjoy it – even if it is different to London, where my children remain and that means I have to stay up late [to talk to them]."
More about...
What is your opinion? Feel free to discuss the article under. You have to comment by using your Facebook profile. Be fair and have respect for other people and opinions!
Being an amiable guy is good for you and Jurgen Klopp is living proof.
Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.


text:
It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is up to you but will dramatically increase your chances of people actually reading your profile and contacting you. Write a few sentences about yourself, your hobbies and attach a nice photograph of yourself.
Use our website's sophisticated search to spot members who match your criteria. Or just scan through listings and spot daters that attract you.
Found someone who looks right? Send them a message or just a wink and see what develops from there. With a little luck you'll be on your way to finding your proper match.
It only takes a few minutes


text:
Core i7
Last week MSI introduced its new X99A Workstation motherboard, part of the X99 refresh we've seen over the past couple of months following the launch of the Broadwell-E processor line. Despite the name 'workstation', this board is based on the consumer-grade Intel X99 PCH rather than the server oriented parts, and as a result it supports overclocking. Part of the 'Workstation' feature set means that it has qualified support for NVIDIA Quadro PCIe cards, compatibility with ECC memory, and a U.2 connector for storage. The manufacturer claims that the mainboard uses special components that can improve the endurance of the board, although the warranty is still listed as three years. Typically, workstation-class motherboards for Intel Xeon E5 v3/v4 processors in LGA2011-3 packaging are based on...
Price Check May 2016: The Intel Core i7-6700K Is Finally Available at Its MSRP
Nine months. This is how long it has taken the retail price of Intel's Core i7-6700K processor to drop to the level recommended by Intel. Despite slow sales of...37 by Anton Shilov on 5/20/2016
Intel Adds Crystal Well-based Skylake-R Processors: 65W with 128MB eDRAM
Intel has added three new microprocessors for embedded and highly-integrated applications into its lineup. The new CPUs are based on the Skylake microarchitecture and feature high-performance integrated graphics cores...66 by Anton Shilov on 5/2/2016
Price Check: Prices of Unlocked Intel Core i7-6700K, i5-6600K Continue to Drop
When Intel first introduced its high-end Skylake-S CPUs with unlocked multiplier about half a year ago, it was not easy to get them and for a long time the...49 by Anton Shilov on 3/29/2016
Price Check: Intel's Unlocked Skylake Processors for Desktops Are Getting More Affordable
Due to unprecedented demand, Intel's latest Skylake processors with unlocked multiplier were significantly overpriced late last year. However, it would seem that more units are coming into retail as...54 by Anton Shilov on 2/16/2016
Compulab Rolls-Out Passively-Cooled Airtop Systems
Compulab, a maker of miniature and small form-factor computers, is introducing its first desktop system called Airtop today. The new computer can be equipped with rather high-performance components, but...35 by Anton Shilov on 1/14/2016
MAINGEAR Rolls-Out 34" All-in-One PC with 18-Core Xeon, GeForce GTX Titan X
The concept of the all-in-one desktop personal computer was created to save space and simplify design of PCs. While there have been a number of traditional AIO desktops available...14 by Anton Shilov on 1/5/2016
Price Check: Intel's Core i7-6700K CPU In Short Supply
Demand for Intel's Skylake CPUs has been very high since the introduction of the company's latest processors in August. Even though the manufacturer has ramped up the supply of...104 by Anton Shilov on 12/30/2015
The Lenovo Yoga 900 Series Launched: The 'Thinnest' Core Laptop and a 27-inch Portable All-In-One
Lenovo's Yoga line has been consistently at the forefront of attempting to define exactly what a combination clamshell laptop 'that's also a sort of tablet' should be. Over the...50 by Ian Cutress on 10/20/2015
The Intel Skylake i7-6700K Overclocking Performance Mini-Test to 4.8 GHz
At the time of our Skylake review of both the i7-6700K and the i5-6600K, due to the infancy of the platform and other constraints, we were unable to probe...107 by Ian Cutress on 8/28/2015
The Intel 6th Gen Skylake Review: Core i7-6700K and i5-6600K Tested
It's the Intel review you've been waiting for. Today is the launch of the first two CPUs from Intel's Skylake architecture, the 6th Generation Core i7-6700K and the Core...475 by Ian Cutress on 8/5/2015
Investigating NVIDIA's BatteryBoost with MSI GT72
BatteryBoost initially launched with the GTX 800M series earlier this year, and our first look at the technology came with the MSI GT70 with GTX 880M. That may not...26 by Jarred Walton on 10/23/2014
Dell XPS 13: A Different Kind of Ultrabook
Late last year, before CES, we had the opportunity to check out Dell's then-upcoming entrant to Intel's nascent ultrabook market, the XPS 13. Dell has been refocusing their XPS...85 by Dustin Sklavos on 3/13/2012
The Ivy Bridge Preview: Core i7 3770K Tested
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text:
(soe ma TROE pin)
Index Terms
- Growth Hormone, Human
- hGH
- Human Growth Hormone
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Subcutaneous:
Norditropin FlexPro: 5 mg/1.5 mL (1.5 mL); 10 mg/1.5 mL (1.5 mL); 15 mg/1.5 mL (1.5 mL); 30 mg/3 mL (3 mL) [contains phenol]
Norditropin NordiFlex Pen: 30 mg/3 mL (3 mL [DSC]) [contains phenol]
Nutropin AQ NuSpin 5: 5 mg/2 mL (2 mL) [contains phenol]
Nutropin AQ NuSpin 10: 10 mg/2 mL (2 mL) [contains phenol]
Nutropin AQ NuSpin 20: 20 mg/2 mL (2 mL) [contains phenol]
Nutropin AQ Pen: 10 mg/2 mL (2 mL [DSC])
Nutropin AQ Pen: 20 mg/2 mL (2 mL [DSC]) [contains phenol]
Omnitrope: 5 mg/1.5 mL (1.5 mL) [contains benzyl alcohol]
Omnitrope: 10 mg/1.5 mL (1.5 mL) [contains phenol]
Solution Reconstituted, Injection:
Humatrope: 5 mg (1 ea)
Humatrope: 6 mg (1 ea); 12 mg (1 ea); 24 mg (1 ea) [contains glycerin, metacresol]
Saizen: 5 mg (1 ea); 8.8 mg (1 ea)
Saizen Click.Easy: 8.8 mg (1 ea)
Saizenprep: 8.8 mg (1 ea) [contains metacresol]
Solution Reconstituted, Subcutaneous:
Genotropin: 5 mg (1 ea); 12 mg (1 ea) [contains metacresol]
Nutropin: 10 mg (1 ea [DSC]) [contains benzyl alcohol]
Omnitrope: 5.8 mg (1 ea)
Serostim: 4 mg (1 ea); 5 mg (1 ea); 6 mg (1 ea)
Tev-Tropin: 5 mg (1 ea [DSC])
Zomacton: 5 mg (1 ea) [contains benzyl alcohol]
Zomacton: 10 mg (1 ea) [contains metacresol]
Zorbtive: 8.8 mg (1 ea) [contains benzyl alcohol]
Solution Reconstituted, Subcutaneous [preservative free]:
Genotropin MiniQuick: 0.2 mg (1 ea); 0.4 mg (1 ea); 0.6 mg (1 ea); 0.8 mg (1 ea); 1 mg (1 ea); 1.2 mg (1 ea); 1.4 mg (1 ea); 1.6 mg (1 ea); 1.8 mg (1 ea); 2 mg (1 ea)
Brand Names: U.S.
- Genotropin
- Genotropin MiniQuick
- Humatrope
- Norditropin FlexPro
- Norditropin NordiFlex Pen [DSC]
- Nutropin AQ NuSpin 10
- Nutropin AQ NuSpin 20
- Nutropin AQ NuSpin 5
- Nutropin AQ Pen [DSC]
- Nutropin [DSC]
- Omnitrope
- Saizen
- Saizen Click.Easy
- Saizenprep
- Serostim
- Tev-Tropin [DSC]
- Zomacton
- Zorbtive
Pharmacologic Category
- Growth Hormone
Somatropin is a purified polypeptide hormones of recombinant DNA origin; somatropin contains the identical sequence of amino acids found in human growth hormone; human growth hormone assists growth of linear bone, skeletal muscle, and organs by stimulating chondrocyte proliferation and differentiation, lipolysis, protein synthesis, and hepatic glucose output; stimulates erythropoietin which increases red blood cell mass; exerts both insulin-like and diabetogenic effects; enhances the transmucosal transport of water, electrolytes, and nutrients across the gut
IM, SubQ: Well absorbed
Vd: Somatrem: 50 mL/kg; Somatropin: 70 mL/kg
Hepatic and renal (~90%)
Urine (0.1%, as unchanged drug)
Duration of Action
Maintains supraphysiologic levels for 18 to 20 hours
Half-Life Elimination
SubQ: Somatrem: 2.3 ± 0.42 hours; Somatropin: 3.8 hours; IM: Somatropin: 4.9 hours
Special Populations: Renal Function Impairment
Patients with chronic renal failure (CRF) and end-stage renal disease (ESRD) have decreased clearance.
Use: Labeled Indications
Treatment of growth failure due to inadequate endogenous growth hormone secretion (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Saizen, Tev-Tropin, Zomacton)
Treatment of growth failure associated with Turner syndrome (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope)
Treatment of growth failure due to Prader-Willi syndrome (PWS) (Genotropin, Omnitrope)
Treatment of growth failure associated with chronic renal insufficiency (CRI) up until the time of renal transplantation (Nutropin, Nutropin AQ)
Treatment of growth failure in children born small for gestational age who fail to manifest catch-up growth by 2 years of age (Genotropin, Omnitrope) or by 2 to 4 years of age (Humatrope, Norditropin)
Treatment of idiopathic short stature (nongrowth hormone-deficient short stature) defined by height standard deviation score (SDS) ≤-2.25 and growth rate not likely to attain normal adult height (Genotropin, Humatrope, Nutropin, Nutropin AQ, Omnitrope)
Treatment of short stature or growth failure associated with short stature homeobox gene (SHOX) deficiency (Humatrope)
Treatment of short stature associated with Noonan syndrome (Norditropin)
HIV patients with wasting or cachexia with concomitant antiviral therapy (Serostim)
Replacement of endogenous growth hormone in patients with adult growth hormone deficiency who meet both of the following criteria (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Saizen):
Biochemical diagnosis of adult growth hormone deficiency by means of a subnormal response to a standard growth hormone stimulation test (peak growth hormone ≤5 mcg/L). Confirmatory testing may not be required in patients with congenital/genetic growth hormone deficiency or multiple other pituitary hormone deficiencies due to organic diseases.
Adult-onset: Patients who have adult growth hormone deficiency whether alone or with multiple hormone deficiencies (hypopituitarism) as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma
Childhood-onset: Patients who were growth hormone deficient during childhood as a result of congenital, genetic, acquired, or idiopathic causes, confirmed as an adult before replacement therapy is initiated
Treatment of short-bowel syndrome (Zorbtive)
Hypersensitivity to somatropin or any component of the formulation; growth promotion in pediatric patients with closed epiphyses; progression or recurrence of any underlying intracranial lesion or actively growing intracranial tumor; acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma or acute respiratory failure; evidence of active malignancy; active proliferative or severe nonproliferative diabetic retinopathy; use in patients with Prader-Willi syndrome without growth hormone deficiency (except Genotropin) or in patients with Prader-Willi syndrome with growth hormone deficiency who are severely obese, have a history of upper airway obstruction or sleep apnea, or have severe respiratory impairment.
Dosing: Adult
Note: Nutropin (lyophilized powder) has been discontinued in the US for more than 1 year.
Growth hormone deficiency: Adjust dose based on individual requirements: To minimize adverse events in older or overweight patients, reduced dosages may be necessary. During therapy, dosage should be decreased if required by the occurrence of side effects or excessive IGF-I levels.
Weight-based dosing:
Norditropin: SubQ: Initial dose ≤0.004 mg/kg/day; after 6 weeks of therapy, may increase dose up to 0.016 mg/kg/day
Nutropin, Nutropin AQ: SubQ: ≤0.006 mg/kg/day; dose may be increased up to a maximum of 0.025 mg/kg/day in patients <35 years of age, or up to a maximum of 0.0125 mg/kg/day in patients ≥35 years of age
Humatrope: SubQ: ≤0.006 mg/kg/day; dose may be increased up to a maximum of 0.0125 mg/kg/day
Genotropin, Omnitrope: SubQ: Weekly dosage: ≤0.04 mg/kg divided into equal doses 6 to 7 days per week; dose may be increased at 4- to 8-week intervals to a maximum of 0.08 mg/kg/week
Saizen: SubQ: ≤0.005 mg/kg/day; dose may be increased to not more than 0.01 mg/kg/day after 4 weeks
Non–weight-based dosing: SubQ: Initial: 0.2 mg/day (range: 0.15 to 0.3 mg/day); may increase every 1 to 2 months by 0.1 to 0.2 mg/day based on response and/or serum IGF-I levels
Dosage adjustment with estrogen supplementation (growth hormone deficiency): Larger doses of somatropin may be needed for women taking oral estrogen replacement products; dosing not affected by topical products
HIV-associated adipose redistribution syndrome (HARS) (off-label use): Serostim: SubQ: Induction: 4 mg once daily at bedtime for 12 weeks; Maintenance: 2 mg or 4 mg every other day at bedtime for 12 to 24 weeks. Note: Every-other-day dosing during induction has also been studied. Although a greater response was seen with daily dosing, it was associated with an increased incidence of adverse events.
HIV patients with wasting or cachexia:
Serostim: SubQ: 0.1 mg/kg once daily at bedtime (maximum: 6 mg/day). Alternately, patients at risk for side effects may be started at 0.1 mg/kg every other day. Patients who continue to lose weight after 12 weeks should be re-evaluated for opportunistic infections or other clinical events; rotate injection sites to avoid lipodystrophy. Adjust dose if needed to manage side effects.
Daily dose based on body weight:
<35 kg: 0.1 mg/kg
35 to 45 kg: 4 mg
45 to 55 kg: 5 mg
>55 kg: 6 mg
Short-bowel syndrome: Zorbtive: SubQ: 0.1 mg/kg once daily for 4 weeks (maximum: 8 mg/day)
Fluid retention (moderate) or arthralgias: Treat symptomatically or reduce dose by 50%
Severe toxicity: Discontinue therapy for up to 5 days; when symptoms resolve, restart at 50% of dose. If severe toxicity recurs or does not disappear within 5 days after discontinuation, permanently discontinue treatment.
Dosing: Geriatric
Patients ≥65 years of age may be more sensitive to the action of growth hormone and more prone to adverse effects; in general, dosing should be cautious, beginning at low end of dosing range.
Dosing: Pediatric
Note: Nutropin (lyophilized powder) has been discontinued in the US for more than 1 year.
Growth hormone deficiency:
Genotropin, Omnitrope: SubQ: Weekly dosage: 0.16 to 0.24 mg/kg divided into equal doses 6 to 7 days per week
Humatrope: SubQ: Weekly dosage: 0.18 to 0.3 mg/kg divided into equal doses 6 to 7 days per week
Norditropin: SubQ: 0.024 to 0.034 mg/kg/day, 6 to 7 days per week
Nutropin, Nutropin AQ: SubQ: Weekly dosage: 0.3 mg/kg divided into equal daily doses; pubertal patients: ≤0.7 mg/kg divided into equal daily doses
Tev-Tropin, Zomacton: SubQ: Up to 0.1 mg/kg/dose administered 3 days per week
Saizen: IM, SubQ: Weekly dosage: 0.18 mg/kg divided into equal daily doses or as 0.06 mg/kg/dose administered 3 days per week or as 0.03 mg/kg/dose administered 6 days per week
Note: Therapy should be discontinued when patient has reached satisfactory adult height, when epiphyses have fused, or when the patient ceases to respond. Growth of 5 cm/year or more is expected, if growth rate does not exceed 2.5 cm in a 6-month period, double the dose for the next 6 months; if there is still no satisfactory response, discontinue therapy
Chronic renal insufficiency (CRI): Nutropin, Nutropin AQ: SubQ: Weekly dosage: 0.35 mg/kg divided into daily injections; continue until the time of renal transplantation
Dosage recommendations in patients treated for CRI who require dialysis:
Hemodialysis: Administer dose at night prior to bedtime or at least 3 to 4 hours after hemodialysis to prevent hematoma formation from heparin
CCPD: Administer dose in the morning following dialysis
CAPD: Administer dose in the evening at the time of overnight exchange
Turner syndrome:
Genotropin, Omnitrope: SubQ: Weekly dosage: 0.33 mg/kg divided into equal doses 6 to 7 days per week
Humatrope: SubQ: Weekly dosage: 0.375 mg/kg divided into equal doses 6 to 7 days per week
Norditropin: SubQ: Up to 0.067 mg/kg/day
Nutropin, Nutropin AQ: SubQ: Weekly dosage: ≤0.375 mg/kg divided into equal doses 3 to 7 days per week
Prader-Willi syndrome: Genotropin, Omnitrope: SubQ: Weekly dosage: 0.24 mg/kg divided into equal doses 6 to 7 days per week
Small for gestational age:
Genotropin, Omnitrope: SubQ: Weekly dosage: 0.48 mg/kg divided into equal doses 6 to 7 days per week
Humatrope: SubQ: Weekly dosage: 0.47 mg/kg divided into equal doses 6 to 7 days per week
Norditropin: SubQ: Up to 0.067 mg/kg/day
Alternate dosing (small for gestational age): In older/early pubertal children or children with very short stature, consider initiating therapy at higher doses (0.067 mg/kg/day) and then consider reducing the dose (0.033 mg/kg/day) if substantial catch-up growth observed. In younger children (<4 years) with less severe short stature, consider initiating therapy with lower doses (0.033 mg/kg/day) and then titrating the dose upwards as needed.
Idiopathic short stature:
Genotropin, Omnitrope: SubQ: Weekly dosage: 0.47 mg/kg divided into equal doses 6 to 7 days per week
Humatrope: SubQ: Weekly dosage: 0.37 mg/kg divided into equal doses 6 to 7 days per week
Nutropin, Nutropin AQ: SubQ: Weekly dosage: Up to 0.3 mg/kg divided into equal daily doses
SHOX deficiency: Humatrope: SubQ: Weekly dosage: 0.35 mg/kg divided into equal doses 6 to 7 days per week
HIV patients with wasting or cachexia (off-label use): Serostim: SubQ: Limited data; doses of 0.04 mg/kg/day were reported in five children, 6 to 17 years of age; doses of 0.07 mg/kg/day were reported in six children, 8 to 14 years of age
Noonan syndrome: Norditropin: SubQ: Up to 0.066 mg/kg/day
Dosing: Renal Impairment
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Dosing: Hepatic Impairment
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Genotropin: Reconstitute with diluent provided.
Genotropin MiniQuick: Reconstitute with diluent provided. Consult the instructions provided with the reconstitution device.
Cartridge: Consult HumatroPen User Guide for complete instructions for reconstitution. Dilute with solution provided with cartridges ONLY; do not use diluent provided with vials.
Vial: 5 mg: Reconstitute with 1.5 to 5 mL diluent provided. Swirl gently; do not shake.
Nutropin: Vial:
5 mg: Reconstitute with 1 to 5 mL bacteriostatic water for injection. Swirl gently, do not shake.
10 mg: Reconstitute with 1 to 10 mL bacteriostatic water for injection. Swirl gently, do not shake.
Omnitrope powder: Reconstitute with provided diluent. Swirl gently; do not shake.
Saizen: Vial:
5 mg: Reconstitute with 1 to 3 mL bacteriostatic water for injection or sterile water for injection. Gently swirl; do not shake.
8.8 mg: Reconstitute with 2 to 3 mL bacteriostatic water for injection or sterile water for injection. Gently swirl; do not shake.
Serostim: Vial: Reconstitute with 0.5 to 1 mL sterile water for injection.
Tev-Tropin, Zomacton: Note: Only use the provided diluent for the 5 mg and 10 mg vial; diluents differ, do not interchange.
5 mg vial: Reconstitute with 1 to 5 mL of provided diluent (bacteriostatic 0.9% sodium chloride for injection [benzyl alcohol preserved]). Swirl gently; do not shake. Use preservative-free NS for injection for use in newborns. When reconstituting with NS for injection, use only one dose per vial; discard unused portion.
10 mg vial: Reconstitute with 1 mL of provided diluent (bacteriostatic water for injection [metacresol 0.33% preserved]). Use the 25-gauge mixing needle provided. Swirl gently; do not shake.
Zorbtive: 8.8 mg vial: Reconstitute with 1 to 2 mL bacteriostatic water for injection. Swirl gently.
Do not shake; administer SubQ or IM (not all products are approved for IM administration); do not inject IV. Rotate administration sites to avoid tissue atrophy. When administering to newborns, do not reconstitute with a diluent that contains benzyl alcohol; sterile water for injection may be used as an alternative.
Norditropin cartridge must be administered using the corresponding color-coded NordiPen injection pen.
Omnitrope: Solution in the cartridges must be administered using the Omnitrope pen; when installing a new cartridge, prime pen prior to first use.
Humatrope: When administering for growth hormone deficiency, SubQ route is preferred.
Tev-Tropin, Zomacton: Administer SubQ injections with standard sterile disposable needle or Tjet Needle-Free (Tev-Tropin) or ZOMA-Jet Needle-Free (Zomacton) injection device.
Dietary Considerations
Prader-Willi syndrome: All patients should have effective weight control (use is contraindicated in severely-obese patients).
Short-bowel syndrome: Intravenous parenteral nutrition requirements may need reassessment as gastrointestinal absorption improves.
Genotropin: Store at 2°C to 8°C (36°F to 46°F); do not freeze. Protect from light. Following reconstitution of 5 mg and 12 mg cartridge, may store under refrigeration for up to 28 days.
Genotropin Miniquick: Store in refrigerator prior to dispensing, but may be stored ≤25°C (77°F) for up to 3 months after dispensing. Store in original carton to protect from light; do not freeze. Once reconstituted, solution must be refrigerated and used within 24 hours. Discard unused portion.
Vial: Before and after reconstitution, store at 2°C to 8°C (36°F to 46°F); do not freeze. When reconstituted with provided diluent or bacteriostatic water for injection, use within 14 days. When reconstituted with sterile water for injection, use within 24 hours and discard unused portion.
Cartridge: Before and after reconstitution, store at 2°C to 8°C (36°F to 46°F); do not freeze. Following reconstitution with provided diluent, stable for 28 days under refrigeration.
Norditropin: Store at 2°C to 8°C (36°F to 46°F); do not freeze. Avoid direct light. When refrigerated, prefilled pen must be used within 4 weeks after initial injection. Orange and blue prefilled pens may also be stored up to 3 weeks at ≤25°C (77°F).
Nutropin: Before and after reconstitution, store at 2°C to 8°C (36°F to 46°F); do not freeze.
Nutropin vial: Use reconstituted vials within 14 days. When reconstituted with sterile water for injection, use immediately and discard unused portion.
Nutropin AQ formulations: Use within 28 days following initial use.
Powder for injection: Prior to reconstitution, store under refrigeration at 2°C to 8°C (36°F to 46°F); do not freeze. Protect from light. Reconstitute with provided diluent. Swirl gently; do not shake. Following reconstitution with the provided diluents, the 5.8 mg vial may be stored under refrigeration for up to 3 weeks. Store vial in carton to protect from light.
Solution: Prior to use, store under refrigeration at 2°C to 8°C (36°F to 46°F). Once the cartridge is loaded into the pen delivery system, store under refrigeration for up to 28 days after first use.
Saizen: Prior to reconstitution, store at room temperature 15°C to 30°C (59°F to 86°F). Following reconstitution with bacteriostatic water for injection, reconstituted solution should be refrigerated and used within 14 days. When reconstituted with sterile water for injection, use immediately and discard unused portion. The Saizen easy click cartridge, when reconstituted with the provided bacteriostatic water, should be stored under refrigeration and used within 21 days.
Serostim: Prior to reconstitution, store at room temperature 15°C to 30°C (59°F to 86°F). When reconstituted with sterile water for injection, use immediately and discard unused portion.
Tev-Tropin, Zomacton: Prior to reconstitution, store at 2°C to 8°C (36°F to 46°F). Following reconstitution with the provided diluents, should be refrigerated and used within 14 days (5 mg vial) or 28 days (10 mg vial); do not freeze. Some cloudiness may occur; do not use if cloudiness persists after warming to room temperature.
Zorbtive: Store unopened vials and diluent at room temperature of 15°C to 30°C (59°F to 86°F). Store reconstituted vial under refrigeration at 2°C to 8°C (36°F to 46°F) for up to 14 days; do not freeze.
Drug Interactions
Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. Monitor therapy
Cortisone: Somatropin may diminish the therapeutic effect of Cortisone. Growth hormone may reduce the conversion of cortisone to the active cortisol metabolite. Consider therapy modification
Estrogen Derivatives: May diminish the therapeutic effect of Somatropin. Shown to be a concern with oral hormone replacement therapy in postmenopausal women. Management: Monitor for reduced growth hormone efficacy. A larger somatropin dose may be required to reach treatment goal. This interaction does not appear to apply to non-orally administered estrogens (e.g., transdermal, vaginal ring). Exceptions: Ethinyl Estradiol; Mestranol. Consider therapy modification
PredniSONE: Somatropin may diminish the therapeutic effect of PredniSONE. Growth hormone may reduce the conversion of prednisone to the active prednisolone metabolite. Consider therapy modification
Adverse Reactions
Cardiovascular: Peripheral edema (short bowel syndrome: 69% to 81%; HARS: 19% to 45%; HIV with wasting/cachexia: 26%), facial edema (short bowel syndrome: 44% to 50%), chest pain (short bowel syndrome: ≤19%), edema (≤13%)
Central nervous system: Pain (short bowel syndrome: 6% to 19%), hypoesthesia (HARS: 9% to 15%; HIV with wasting/cachexia: 5%), headache (≤14%), malaise (short bowel syndrome: ≤13%), paresthesia (8% to 13%), dizziness (short bowel syndrome: 6% to 13%)
Dermatologic: Diaphoresis (short bowel syndrome: ≤13%), skin rash (short bowel syndrome: 6% to 13%)
Endocrine & metabolic: Dehydration (short bowel syndrome: ≤19%)
Gastrointestinal: Nausea (short bowel syndrome: 13% to 31%; HIV with wasting/cachexia: 9%), flatulence (short bowel syndrome: 25%), abdominal pain (short bowel syndrome: 13% to 25%), vomiting (short bowel syndrome: 19%)
Infection: Infection (short bowel syndrome: ≤19%), candidiasis (short bowel syndrome: ≤13%)
Local: Pain at injection site (short bowel syndrome: ≤31%), injection site reaction (short bowel syndrome: 19% to 25%, idiopathic short stature: <1%)
Neuromuscular & skeletal: Arthralgia (HIV with wasting/cachexia: ≤78%; HARS, short bowel syndrome: 28% to 44%; idiopathic short stature, SHOX deficiency: 11%), arthropathy (HIV with wasting/cachexia: ≤78%; idiopathic short stature: 11%), myalgia (HIV with wasting/cachexia: ≤78%, idiopathic short stature: 24%; HARS, short bowel syndrome: ≤13%), scoliosis (idiopathic short stature: 19%; SHOX deficiency: 4%), limb pain (HARS: 5% to 19%)
Otic: Otitis media (Turner syndrome: 43%; idiopathic short stature: 16%), ear disease (Turner syndrome: 18%), auditory disturbance (short bowel syndrome: 13%)
Respiratory: Rhinitis (short bowel syndrome: ≤19%)
Miscellaneous: Surgery (Turner syndrome: 45%)
1% to 10%:
Cardiovascular: Hypertension (idiopathic short stature: 3%)
Dermatologic: Nevus (excessive; SHOX deficiency: 7%)
Endocrine & metabolic: Hyperlipidemia (idiopathic short stature: 8%), gynecomastia (≤8%)
Neuromuscular & skeletal: Hip pain (idiopathic short stature: 3%)
Frequency not defined:
Cardiovascular: Lower extremity edema (adults; growth hormone deficiency)
Central nervous system: Depression (adults; growth hormone deficiency), fatigue (adults; growth hormone deficiency), insomnia (adults; growth hormone deficiency), seizure (children; growth hormone deficiency)
Dermatologic: Acne vulgaris (adults; growth hormone deficiency), exacerbation of psoriasis (children; growth hormone deficiency)
Endocrine & metabolic: Decreased glucose tolerance (adults; growth hormone deficiency), glycosuria (growth hormone deficiency), hyperglycemia (mild; growth hormone deficiency, small for gestational age), hypertriglyceridemia (children; growth hormone deficiency), hypoglycemia (children; growth hormone deficiency), hypothyroidism (growth hormone deficiency), insulin resistance (adults; growth hormone deficiency)
Gastrointestinal: Gastritis (adults; growth hormone deficiency)
Genitourinary: Hematuria (children; growth hormone deficiency), precocious puberty (small for gestational age), urinary tract infection (Turner syndrome)
Hematologic & oncologic: Elevated glycosylated hemoglobin (children; growth hormone deficiency), eosinophilia (children; growth hormone deficiency), hematoma (children; growth hormone deficiency), leukemia (children; growth hormone deficiency), meningioma (children, growth hormone deficiency), neoplasm (intracranial; children; growth hormone deficiency)
Hepatic: Increased serum ALT (adults; growth hormone deficiency), increased serum AST (adults; growth hormone deficiency)
Immunologic: Antibody development (children; growth hormone deficiency)
Neuromuscular & skeletal: Back pain (adults; growth hormone deficiency), leg pain (children; growth hormone deficiency), lipoatrophy (children; growth hormone deficiency), muscle rigidity (adults; growth hormone deficiency), skeletal pain (adults; growth hormone deficiency), slipped capital femoral epiphysis (small for gestational age; children, growth hormone deficiency), weakness (growth hormone deficiency)
Ophthalmic: Papilledema (children; growth hormone deficiency), retinopathy (adults; growth hormone deficiency)
Respiratory: Bronchitis (adults; growth hormone deficiency), cough (adults; growth hormone deficiency), flu-like symptoms (adults; growth hormone deficiency), pharyngitis (adults, growth hormone deficiency), respiratory tract disease (Turner syndrome), upper respiratory tract infection (adults, growth hormone deficiency)
<1%, postmarketing, and/or case reports: Aggressive behavior (idiopathic short stature), alopecia (idiopathic short stature), carpal tunnel syndrome (small for gestational age), diabetes mellitus (idiopathic short stature, small for gestational age), enlargement of facial features (jaw prominence; small for gestational age), increased growth of pre-existing nevi (growth hormone deficiency, small for gestational age), pancreatitis (growth hormone deficiency), pseudotumor cerebri, scoliosis progression (small for gestational age)
Concerns related to adverse effects:
• Fluid retention: May occur frequently in adults during use; manifestations of fluid retention (eg, edema, arthralgia, myalgia, nerve compression syndromes/paresthesias) are generally transient and dose dependent.
• Hypersensitivity: Reactions are possible; monitor closely.
• Intracranial hypertension (IH): IH with headache, nausea, papilledema, visual changes, and/or vomiting has been reported; symptoms usually occur within the first 8 weeks of therapy and IH signs and symptoms may rapidly resolve after discontinuation or reduction of dose. Funduscopic examination prior to initiation of therapy and periodically thereafter is recommended. Treatment should be discontinued in patients who develop papilledema; resuming treatment at a lower dose may be considered once IH-associated signs and symptoms have resolved. Patients with Turner syndrome, chronic renal failure and Prader-Willi syndrome may be at increased risk for IH.
• Neoplasm: Use in contraindicated with active malignancy. Preexisting malignancy should be inactive and treatment complete prior to instituting therapy; discontinue therapy with evidence of recurrence or progression. Monitor patients with preexisting tumors or growth failure secondary to an intracranial lesion for recurrence or progression of underlying disease. An increased risk of second neoplasm has been reported in childhood cancer survivors treated with somatropin; the most common second neoplasms were meningiomas in patients treated with radiation to the head for their first neoplasm. Patients with HIV and pediatric patients with short stature (genetic cause) have increased baseline risk of developing malignancies; consider risk/benefits prior to initiation of therapy and monitor these patients carefully. Monitor all patients for any malignant transformation of skin lesions.
• Pancreatitis: Has been rarely reported; incidence in children (especially girls) with Turner syndrome may be greater than adults.
• Slipped capital epiphyses: Patients with endocrine disorders (including growth hormone deficiency and Turner syndrome) or in patients undergoing rapid growth may develop slipped capital epiphyses more frequently; evaluate any child with new onset of a limp or with complaints of hip or knee pain.
Disease-related concerns:
• Acute critical illness: Initiation of somatropin is contraindicated with acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma, or acute respiratory failure; mortality may be increased. The safety of continuing somatropin in patients who develop these illnesses during therapy has not been established; use with caution.
• Childhood-onset adult growth hormone deficiency (GHD): Children with epiphyseal closure who are treated with somatropin replacement therapy should be reassessed before continuation of therapy at reduced dose recommended for GH deficient adults.
• Diabetes mellitus: Use with caution in patients with diabetes or with risk factors for impaired glucose tolerance; may decrease insulin sensitivity. New-onset type 2 diabetes mellitus has been reported. Risk factors for diabetes in this population include obesity, Turner syndrome, or a family history of diabetes. Adjustment of antidiabetic medications may be necessary.
• Hypoadrenalism: Patients who have or are at risk for pituitary hormone deficiency(s) may be at risk for reduced serum cortisol levels and/or unmasking of central (secondary) hypoadrenalism with somatropin therapy; patients with previously diagnosed hypoadrenalism may require increased dosages of glucocorticoids (especially cortisone acetate and prednisone) due to somatropin-mediated inhibition of 11 beta-hydroxysteroid dehydrogenase type 1. Excessive glucocorticoid therapy may inhibit the growth promoting effects of somatropin in children; monitor and adjust glucocorticoids carefully.
• Hypopituitarism: Closely monitor other hormonal replacement treatments in patients with hypopituitarism.
• Hypothyroidism: Untreated/undiagnosed hypothyroidism may decrease response to therapy; monitor thyroid function test periodically and initiate/adjust thyroid replacement therapy as needed.
• Noonan syndrome: Safety and efficacy have not been established for the treatment of Noonan syndrome in children with significant cardiac disease.
• Obesity: Increased incidence of adverse events may occur when using a weight-based dosing regimen.
• Prader-Willi syndrome: Fatalities have been reported in pediatric patients with Prader-Willi syndrome following the use of growth hormone. The reported fatalities occurred in patients with one or more risk factors, including severe obesity, history of upper airway obstruction or sleep apnea, respiratory impairment, or unidentified respiratory infection; male patients with one or more of these factors may be at greater risk. Monitor for sleep apnea, upper airway obstruction and respiratory infections. Treatment interruption is recommended in patients who show signs of upper airway obstruction, including the onset of, or increased, snoring and/or new onset sleep apnea.
• Scoliosis: Progression of scoliosis may occur in children experiencing rapid growth.
• Turner syndrome: Patients with Turner syndrome are at increased risk for otitis media and other ear/hearing disorders, cardiovascular disorders (including stroke, aortic aneurysm/dissection, hypertension), and thyroid disease; monitor carefully.
Concurrent drug therapy issues:
• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
Special populations:
• Elderly: Elderly patients may be more sensitive to the actions of somatropin; consider lower starting doses.
• HIV patients: Patients with HIV infection should be maintained on antiretroviral therapy to prevent the potential increase in viral replication.
Dosage form specific issues:
• Benzyl alcohol and derivatives: Diluent may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity ("gasping syndrome") in neonates; the "gasping syndrome" consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer's labeling.
• M-cresol: Some products may contain m-cresol as a preservative.
• Multiple dose injection pens: According to the Centers for Disease Control and Prevention (CDC), pen-shaped injection devices should never be used for more than one person (even when the needle is changed) because of the risk of infection. The injection device should be clearly labeled with individual patient information to ensure that the correct pen is used (CDC 2012).
Other warnings/precautions:
• Administration: Not for IV injection. Subcutaneous administration sites must be rotated to prevent tissue atrophy.
Monitoring Parameters
Growth curve, Tanner staging (children), periodic thyroid function tests, bone age (annually), periodical urine testing for glucose, somatomedin C (IGF-I) levels; funduscopic examinations at initiation of therapy and periodically during treatment; serum phosphorus, alkaline phosphatase and parathyroid hormone. If growth deceleration is observed in children treated for growth hormone deficiency, and not due to other causes, evaluate for presence of antibody formation. Periodic blood glucose monitoring; strict blood glucose monitoring in patients with diabetes. Progression or recurrence of pre-existing tumors or malignant transformation of skin lesions. Note: Practice guidelines recommend monitoring for efficacy and adverse effects every 1-2 months during dose titration and semiannually, thereafter (TES, 2006).
CRI: Progression of renal osteodystrophy
Prader-Willi syndrome: Monitor for sleep apnea, respiratory infections, snoring (onset of or increased)
Turner syndrome: Ear disorders including otitis media; cardiovascular disorders
Noonan syndrome: Prior to use, verify short stature syndrome.
Pregnancy Risk Factor
B/C (depending upon manufacturer)
Pregnancy Considerations
Adverse events have not observed in animal reproduction studies, however, reproduction studies have not been conducted with all agents. During normal pregnancy, maternal production of endogenous growth hormone decreases as placental growth hormone production increases. Data with somatropin use during pregnancy is limited.
Patient Education
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience headache, loss of strength and energy, muscle rigidity, insomnia, or nausea. Have patient report immediately to prescriber signs of high blood sugar (confusion, fatigue, increased thirst, increased hunger, polyuria, flushing, fast breathing, or breath that smells like fruit), signs of pancreatitis (severe abdominal pain, severe back pain, severe nausea, or vomiting), signs of adrenal gland problems (severe nausea, vomiting, severe dizziness, passing out, muscle weakness, severe fatigue, mood changes, lack of appetite, or weight loss), signs of severe cerebrovascular disease (change in strength on one side is greater than the other, difficulty speaking or thinking, change in balance, or vision changes), shortness of breath, mood changes, depression, vision changes, angina, numbness or tingling of hands or feet, swelling of arms or legs, bone pain, severe muscle pain, severe joint pain, mole changes, hematuria, injection site redness or edema, skin thinning, injection site skin breakdown, or signs of increased intracranial pressure (vision changes, severe headache, nausea, or vomiting) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
More about somatropin
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 20 Reviews – Add your own review/rating
- Drug class: growth hormones
Consumer resources
Professional resources
Other brands: Genotropin, Omnitrope, Norditropin, Humatrope, More... (7)


text:
Red Hat Bugzilla – Bug 241395
FC6 -> F7 anaconda upgrade traceback
Last modified: 2013-09-02 02:20:44 EDT
# RPM anaconda-22.214.171.124-1.x86_64.rpm
# ARCH x86_64
Probing for video card: nVidia Corporation NV44 [Quadro NVS 285]
Traceback (most recent call last):
File "/usr/bin/anaconda", line 949, in <module>
File "/usr/lib/anaconda/kickstart.py", line 1056, in setSteps
AttributeError: 'bool' object has no attribute 'setSteps'
Attaching anaconda-logs.tgz (not the tmp/anaconda.log includes several attempts
to recreate the failure in order to capture the output)
(~)> tar -ztvf ~/Desktop/anaconda-logs.tgz
-rw-r--r-- root/root 23134 2007-06-01 20:58:34 tmp/syslog
-rw-r--r-- root/root 65056 2007-06-01 21:16:35 tmp/anaconda.log
-rw------- root/root 1017 2007-06-01 21:15:19 tmp/ks.cfg
-rw-r--r-- root/root 338 2007-06-01 21:16:35 tmp/trace.txt
I believe this is the RC2 tree (.treeinfo below):
family = Fedora
timestamp = 1180061782.66
variant = Fedora
totaldiscs = 1
version = 7
discnum = 1
packagedir = Fedora
arch = x86_64
Created attachment 155469 [details]
Fixed in head, and I think we're going to pull this into an updates.img.
I'm hitting this - is the updates.img available?
This bug is now addressed by an updates image. It is available for download at:
Instructions for using updates disks are located at:
If possible, please test this image out and report if it fixes your issue or
not. Once we are confident that your issue is solved by this image, we are
going to announce it more publicly. This fix may also be included in an updated
anaconda package later for people who are making custom Fedora distributions.
Thanks for your time.
update bombs with:
/tmp/updates/kickstart.py line 30
import pykickstart.commands as commands
ImportError: No module named commands
Thanks for the report. Please try it now.
Anaconda starts up okay, but then it asks how I want to partition the disk
rather than upgrading the existing install.
Sounds like anaconda is not detecting your existing installation and therefore
doesn't give you the option of install vs. upgrade. What's your layout? What's
in the anaconda log files? This may be better served with a different bug, in fact.
Opened bug #243159 for the upgrade issue.
Chris -
Any chance that the anaconda fixes for this will be released as a F7 update so
that respins of an updated F7 work?
I've committed the fixes in the updates.img to the F7 branch of anaconda. We'll
probably build a new one in a few weeks to give more time to see what are the
really common bugs. Then, anyone who wants to make a new F7 can take advantage
of the fixes.
Excellent! Thanks!
*** Bug 248596 has been marked as a duplicate of this bug. ***
*** Bug 253227 has been marked as a duplicate of this bug. ***
I am trying to do a kickstart upgrade from a custom FC6 to a custom FC7 distro.
After encountering the known issue (line 949), I downloaded the f7-updates.img
file, renamed it to updates.img and put it under the images/ folder of my custom
distro cd. The installer then continues till it displays the 'transferring
install image to harddrive' message. I then get the error show below. Is it at
all possible to use the updates like this (in the images/ folder of the cd), as
the wiki states that is is possible to do this with network install.
Traceback (most recent call first):
File "/tmp/treedir.27118/instimage/usr/lib/anaconda/isys.py", line 244, in
_isys.lochangefd(loop, targ)
File "/usr/lib/anaconda/image.py", line 188, in systemMounted
isys.lochangefd("/tmp/loop", self.loopbackFile)
File "/tmp/treedir.27118/instimage/usr/lib/anaconda/yuminstall.py", line 1107,
in doPreInstall
if self.method.systemMounted (anaconda.id.fsset, anaconda.rootPath):
File "/tmp/treedir.27118/instimage/usr/lib/anaconda/backend.py", line 230, in
File "/usr/lib/anaconda/dispatch.py", line 203, in moveStep
rc = stepFunc(self.anaconda)
File "/usr/lib/anaconda/dispatch.py", line 126, in gotoNext
File "/usr/lib/anaconda/text.py", line 605, in run
File "/tmp/updates/anaconda", line 955, in <module>
SystemError: (6, 'No such device or address')


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text:
Car GoesMature
Inspired by 'Cargoes', by John Masefield - a poem I remember fondly from primary school.
Japanese Toyota car from distant Essex;
Driver having trouble reading French road signs;
With a cargo of bottled ale
And cans in six-packs,
Blonde beer, alcopops, and cheap red wines.
Stately Ford Mondeo coming from the Carrefour,
Cruising back to Calais Port in the slow lane,
With a cargo of Kronenbourg,
Stella Artois,
Hoegaarden, and Grolsch and Becks and Castlemaine.
Dirty Stena ferry with a grime-caked funnel,
Butting through the Channel in the hot June sun,
With a cargo of bargain booze
In cars and white vans,
Stocking up for barbecues and summer fun.


text:
From 21st November to 30th December 2016
Christkindelsmarkt Baden-Baden:
Situated at the start of Baden-Baden's world-famous green corridor, the Lichtentaler Allee, visitors will encounter small streets of festive stalls, where the romantic atmosphere is heightened by the thousands of shimmering Christmas lights. The entire experience is capped with a choice program of entertainment, catering for both young and old.
In front of the impressive Kurhaus building, where festively decorated stalls run parallel to the exclusive colonnade boutiques, the scene is aglow with twinkling lights and candles.
As one of the region's largest and prettiest Christmas markets, it invites you until 30th December to marvel, browse and shop. Around 100 stalls await you with a selection of arts and crafts, Christmas decorations, handcrafted nativity scenes and much more. Younger visitors can look forward to tasty Christmas treats, a children's bakery, merry-go-rounds and a program of Christmas entertainment on the open-air stage.
Best hotels for Christmas
in Baden-Baden
Christmas in Baden-Baden
image gallery
Top things to do
for Christmas in Baden-Baden
Visit of the Casino Baden-Baden
Germany's oldest casino and "most beautiful casino in the world" due to the words of Marlene Dietrich is located in the Kurhaus. With a history of more than 250
years the beautiful halls - fashioned on the lines of French royal palaces – have always been a temple to the alluring game of chance. The Casino Baden-Baden rounds off a perfect
day in a playful manner and entices international guests to try their luck at the roulette table.
The Caracalla Spa and the "Friedrichsbad"
Over 2.000 years ago the Romans discovered the healing powers of the 12 springs and built the first thermal baths. Today the modern Caracalla Spa offers 4.000 sqm of soothing relaxation in curative thermal water.
For over 130 years Roman traditional bathing culture has been combined with the habit of Irish hot-air bathing in the historic "Friedrichsbad". Floating in the healing thermal water surrounded by artful frescoes of the historic bathing temple guarantees relaxation at the highest level.
The "Festspielhaus" - Europe's second largest opera and concert hall
Cultural pleasure at the highest level is offered at the "Festspielhaus" – Europe's second largest opera and concert hall. With its world acclaimed acoustics,
the "Festspielhaus" offers over 300 top class events yearly such as "The Magic Flute", "Swan Lake" or "The Nutcracker" with world famous artists like Anne-Sophie Mutter, Lang Lang, Anna Netrebko,
the Mariinsky-Ballett or the Berlin Philharmonic Orchestra.


text:
Locations with one appearance
Category page
12,401pagesAdd New Page
on ESB
on ESB
Pages in category "Locations with one appearance"
" Bikini Bell is a telephone company in Bikini Bottom. It was only mentioned by SpongeBob in the...
Bikini Bell
One Appearance Category
The following is an one appearance category. The purpose of this category is to gather articles in which something has appeared once in the series, and may require additional information that would be easy to find, as there is only one appearance.


text:
People at Savannah: Olivier le Monnier Profile
Follows the Profile of Olivier le Monnier <olm>.
Open Items submitted by Olivier le MonnierNone found
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General Information
|Real Name:
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|Login Name:
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|This user did not enable his/her Resume & Skills.
|Download GPG Key
Project/Group Information
- GNU French Translation Team
Member since Mon Feb 13 20:36:28 2012
You Could Send a Message if you were logged in.


text:
Poorer households that rely on Economy 7 tariffs face some of the steepest rises to energy bills in the coming weeks, with some customers paying 35% more for their night-time electricity than they were 13 months ago.
In the week that energy bosses appeared in the House of Commons to defend their 8%-10% "average" price rises, it has emerged that some SSE customers on the Economy 7 tariff will see part of their bills rise by 17% later this month. The increase comes on top of a 15% increase imposed this time last year.
SSE's managing director, William Morris, told MPs this week that he profoundly regretted having to put prices up by an average of 8.2%. SSE has 500,000 households on Economy 7 bills.
Scottish Power and Npower also imposed night-time tariff hikes of around 13% in the eastern region alone when they put up prices last month.
The increases will particularly affect vulnerable households that rely on electric storage heaters, many of which are installed in social housing.
Around 10% of UK households are thought to use the Economy 7 tariff, which offers significantly cheaper electricity for seven hours at night. Users typically heat hot water cylinders and recharge storage heaters at the lower rate, but pay more than standard customers for electricity used during the day.
One SSE customer who contacted the Guardian this week said he was appalled when he opened a letter from SSE announcing the price increase, which takes effect on 15 November. "There was no mention of the previous price or the percentage that the Economy 7 rate would go up by. Only when I looked at what I had been paying did the true size of the price increase emerge," he said.
The customer, who wished not to be named, said SSE's Economy 7 tariff night-time rate in his area had increased from 5.98p per unit to 6.92p per unit on 15 October 2012 and is about to increase to 8.11p per unit: a 35.6% increase in 13 months.
"This tariff is used especially by people with storage heaters, where it will constitute their major energy cost. I guess that this will include a disproportionate number of both poor people and old people – this is exactly the politically sensitive group whom you might think energy suppliers would try to hit less, not more," he said.
On Thursday, SSE again blamed the steep price increase on government levies, which it said were beyond its control.
The company added: "SSE has capped the rate increase, however, to ensure that the Economy 7 tariff remains cheaper than the general domestic tariff wherever off-peak usage accounts for more than 30% of the total."
SSE said it was campaigning against "the unfair penalisation of electricity-only customers due to the disproportionate way in which the cost of government schemes are levied on electricity usage, [which] often means that customers who can least afford it end up paying the most towards government schemes".
Mark Todd of Energyhelpline.com said: "The price announcements by the energy firms are always averages and invariably disguise some bigger increases, and it looks as though Economy 7 customers are being harder hit than others."


text:
Earlier posts from the SG1 Series:
What, Why, Who, How – Questioning Formula?
Many writers learn to emulate or procreate success by following or developing a specific formula. We begin the journey of a writer in the footsteps of our favorites, the classics and contemporaries who walked these hallowed halls before us, but in time we learn to strike out on our own. We develop our own voice, our own techniques and our own formulas.
Television Series are almost entirely dependent on formula. Formula allows multiple writers to follow steps to create a consistent product. Category Romance are often formulaic as well. Indeed many aspects of business (writing or otherwise) coexist around formula, from business models to time management and of course content.
Formula is about reusing what has proven to work. While there is little point in repeating actions that were unsuccessful, we know that success can often be recreated by following similar steps. The Stargate Series continued to produce successful seasons, year after year, thanks to their carefully structured formula. Category Romances are enjoyed by thousands of women around the world because we all know they have happy endings, it's part of the formula. Success, developed into a success formula can recreate success.
For first time novelists this might seem like information you can't use. After all, we need to have those first successes to create a success formula, right? Nope, not at all. That's where emulation plays a significant role in the early success of writers. It is one of the reasons a love of reading is almost a prerequisite for writers. The more you read the more you will absorb the method and technique, the formulas, of other writers.
Worship at the Author Altar by Reading
Books should obviously be our first love. After all, as novelists we are determined to spend hour upon hour in company with them every single day. When we aren't writing our own we are, hopefully, kicking back with one of the many books that gather in teetering piles on any available flat surface (or stacked neatly on a bookshelf if you're the rare mythological being, a neat writer).
The books we read offer lessons to all writers. With time and experience writers develop an eye that tends to transform the reading process. The luckiest of us don't find this dilutes the joy of reading but sometimes it can feel like we are still working in our off hours.
Read as much as you possibly can. Don't be afraid to deviate from your favorite authors, genres, or first publication dates. Read classics, thrillers, fillers, any book that stumbles into your hands both fiction and non-fiction. Become your libraries most loyal visitor and steal moments to read whenever you can. This firm foundation of language and technique is the cement pad on which you'll build a house of writing.
Pester, Prod, Ask Questions, and Be Interested
We have a surprising number of opportunities throughout life to learn. Writers' conferences, talk shows, podcasts, blogs, writers' groups, book readings, etc. all provide a marvelous chance to pick apart the brains of other writers. Don't be afraid to ask questions. If you show a true interest and a willingness to learn most writers will be available for you (to a point). You can learn a great deal about writing and success from published authors, interviews, and the media. Absorb and question, analyze and compare. Become an avid busy-body and learn to ask the right questions to get the answers you can use.
Recreate a Success Formula – Write!
With what you learn from reading and questioning, from watching television and movies and listening to the world you will have found consistencies you can use to begin to develop your own success formula. Publisher guidelines and writing magazines are another place to dig. By pulling these threads of knowledge together you can structure the walls of your success.
Recreate and emulate the successful techniques you've discovered but be prepared to grow and adjust. A formula never works perfectly if it is identical every time. You must change as needed. This takes practice and the only way you will succeed is to learn to fail. Writers never get it right every time. We get better with failure, we learn, we develop, we grow into success.
The Book's Formula
Just as you've created a formula for success many books can follow a formula that also aids their success. It is done in much the same way. By learning what works and working what you've learnt. Remember to adjust when needed and to practice. A Book Formula is most common for book series and some very specific genres. Many of the most prolific writers have learnt to use formula to produce multiple books that stand alone on their own merit but follow consistent patterns that fans enjoy and come to expect.
Don't be afraid to emulate formula while you begin as a writer but don't forget how vital it is to discover your own voice, and walk the path in your own shoes. Yes, you can learn to be successful by following in the footsteps of successful people but the most successful learn to strike out on their own, they take paths less traveled and that makes all the difference.


text:
Is this restaurant appropriate for Kids?
Is this restaurant wheelchair accessible?
Is this restaurant family-friendly?
Does this restaurant accept bookings?
Are the prices at this restaurant mid-range / moderate?
Is this restaurant good for lunch?
Is this restaurant good for dinner?
Is this restaurant good for brunch?
Can a gluten free person get a good meal at this restaurant?
Does this restaurant offer free wifi?
Thanks for helping!
You get a choice of three curries I love their yellow curry best. And they have a nice variety of other Thai foods.
Excellent Pad Thai! Great service! Wonderful Thai Iced tea! Highly recommended. All of the menu items looked excellent. I had the Pad Thai with sea food. More food than I could finish.
I never tried their food but their service is not nice! Went there on Wednesday (8/31) and try to pre order some food for a party on Sunday. The lady come out and say if it is on Sunday I can come back again to order on Saturday and her excuse they will get busy and may forget my order....
Have eaten here a couple of times in a group, and been equally disappointed with the food both times. Food, service, and ambiance are mediocre.
We moved to the Castro Valley area three months ago. This restaurant was recommended by a Coit carpet cleaner who cleaned our carpet before we moved in. When we moved, we were still in boxes, we wanted to take a chance and try Pad Thai. We have been a return customer several times in the last three months. They ARE...
With a couple of decent Thai restaurants in CV, I'd put Pad Thai right up there at the top. Clean and comfortable, good menu selection, affordable prices, and excellent service. Tom Kha Gai soup is very good - one of our favorites. My wife and I both had spicy dishes --- and they were SPICY! But you can also tone...
Our friends and family members have been eating here for many years and always have a good experience. Their lunches and dinners are fantastic value !
We were in the mood for something Asian on a Sunday night. Our usual places were closed. We tried this place for the first time and were disappointed. The service was slow and the food was not impressive. We will not go back.
On the busy street of Castro Valley Blvd, lies a house with parking in the back. My co-worker brought me here for lunch for a quiet and healthy meal. So small, I would believe, this would be primarily word of mouth to eat here. Well worth it.
Walk up the front porch and enter what used to be the living...
We have been eating at this little place for years, through several changes in the kitchen. Fair to say, the service was ALWAYS friendly and caring, while the cooking may have ranged from great to merely OK+. As of the current regime, 2013, I rate it at an all time high. They have, I think, arrived at the level of...
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.
Do they deliver? What is their phone number?
See all questions


text:
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text: High-end Quality Anti-fatigue Kitchen Mat Waterproof And Anti-slip Comfort Kitchen Sink Mats Anti-tr - Quanzhou Shunjie Trade Co., Ltd. Toggle navigation TRADE DEALS Products Companies Product Company Search LOGIN E-mail Password Remember me Join Free JOIN FREE HomeAgriculture Rubber & Plastics High-end Quality Anti-fatigue Kitchen Mat Waterproof And Anti-slip Comfort Kitchen Sink Mats Anti-tr PRICE: contract price Product Description As one of the leading kitchen mat suppliers in China, Shunjie Trading Co.,Ltd has professional factory, welcome to get ergonomic floor mats, kitchen fatigue mats, kitchen mat anti fatigue at a good price from us.High-end Quality Anti-fatigue Kitchen Mat Waterproof and Anti-slip Comfort Kitchen Sink Mats Anti-tress Cushion Pad Chef Mats In Size 20*30*3/4 Inch Product SpecificationItem NameAnti Fatigue Kitchen MatsItem NO.SP-KM306Place of OriginFujian, ChinaMain MaterialPUSize20"*30"*3/4" (customized)ColorBlack or any color your prefer.StylePuzzlePatternPrintedTechnologyHandmadeAge GroupAdultsDesignOrientalFeatureAnti-Bacteria, Anti-Slip, Corrosion-Resistant, Waterproof, Wrinkle-ResistantUsageIt can be used as exercise mat, floor mat, outdoor mat, kitchen mat, door mat, stand mat, and so on.CertificationTUV, SGS, ISOCustomizedYesSampleAvailableSample Time7-15daysProducts Function 1.Adopt advanced technology and high-grade material to make this anti fatigue kitchen mat to meet modern people's high requirement of comfort and health. 2.This kitchen mat is easily cleanable and movable. It will not affect the normal working environment. 3.The main material of this kitchen mat is just perfect soft for relieving pressure on back, waist, legs and feet effectively. Simultaneously reduces 50% fatigue of human bodies. It is also able to improve blood circulation and prevent from Varicose veins which is mainly caused by prolonged standing. 4.The special 4 layers structure can transfer the weight masterly and facilitate the legs muscles relaxed.Products PicturesTUV CertificationFactory InformationRelated ProductsAnti Fatigue Office Standing MatAnti Fatigue Door MatAnti Fatigue Salon MatAnti Fatigue Fitness MatAnti Fatigue Kneeling MatAnti Fatigue Yoga MatAnti Fatigue Medical Mat Anti Fatigue Floor Mat Payment TermPacking&Shipping1.PackingMOQ:500PCS per colorPacking Detail: 1pc/ploy bag 10pcs/carton2.Delivery Time30-50days after deposit receiving.3.ShippingFAQ1.Q:How many pieces of kitchen mats can your factory produce every month? A:It is about 15000pieces/month.2.Q:Can you customize this kitchen mat in size, color or design? A:Yes, any your size, color or design is welcome. Just feel free to contact us and advise.3.Q:Can you tell me how to clean this kitchen mat? A:It is very easy. Just use wet clothing and light wipe it. Other products New arrival exercise folding pu anti fatigue mat natural workout best fitness mats Price: contract price Best gym floor mats pu sport mats for fitness equipment in customized size, with good anti-tear func Price: contract price High quality foam nbr kneeling mat portable anti-slip industrial anti-fatigue mat in size 20*36 inch Price: contract price New arrival anti-fatigue office floor mat for office anti-slip standing table pads in size 20*30 inc Price: contract price Company Info Quanzhou Shunjie Trade Co., Ltd. Contact Person: meizong zhang Phone: 86-0595-28272266 Contact now × Contact form Your name: Your E-mail: Your Phone: Subject: Enter a message: Close


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MLS #1690693 Official listing information! neighborhood - 812 Nashville Hwy located in Columbia TN 38401, priced at $950,000, with bedrooms.812 Nashville Hwy Columbia TN - MLS #1690693 Close
Commercial for sale in Columbia, TN at 812 Nashville Hwy. This commercial is priced at $109/sqft.
American Legion Hall.
Listing information last updated on May 28th, 2017 at 1:47am CDT.
Have any comments or questions about 812 Nashville Hwy, Columbia, TN? Ask your question and/or share your thoughts about this property.


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Helios Underwriting (HUW) has made a further acquisition in its continuing strategy to increase capital via acquisitions.
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Helios, Nameco, Lloyd's, Nigel Hanbury, Insurance, Europe