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July 18, 1749
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Issue Date:
Friday, July 18, 1749
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Previous Edition:
Thursday, July 17, 1749
Next Edition:
Saturday, July 19, 1749
Daily Advertiser
Publication Name:
Daily Advertiser
London, Middlesex
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Years Available:
1743 - 1848
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Daily Advertiser (Newspaper) - July 18, 1749, London, Middlesex The Daily .Advertifef. T U i: S D A Y, J iLY IS. i-.ir r:i RRIVI). the nihopfioinc. AyrfS f'io.;� trilU^i. Ttic i:iir$ ai per ia:�, letiuin. Wind S W. VeftcrJay arrived a Miil ffoin M/tiri-^, Jafj a Tbc Coatt �.as f.T.t 9n fxpjxlj to Or.n, wiU Ol-Jcrj to tJio Governor relative t)> inc great f ic^ , J"b '^'"^ MirnnJerflandiog trifcn between tbis Court, and the IIc!y S^. in regard to the Dcfertcrs ivho have taken Refuge io Iknerento. is not yet determined, ind'li* M^jcR/ has given 0.-tler� to reinforce il-e TfOOJp* ^*hich form the Blockide of thit Place, wi'h (cVeril t''* Workmea employed at I'ortici to finifli'tiic pifcdvcry of the \'etlrgc3 ot the anttcnt City ^f HeMclee. fiaving foucd therein fcrcral more Statues of fine Marble, have lent them to the Ro^al Palace. ttghorn, yufy 4. The Q;;arantine which fcvcral l'owcr$ bate imj-ofcd ujo" Ships coming from hence, occaiions tkis iVrt to be lcf� fre cci Ake the necrflaty Ivlealurcs 10 prevent it. Patnw, "July 8. M:Kianie ^-aipcncro, the Ladr of �kc Prime iVlinillcr of ihc Iii;�nt Dukc. and wt;o u&s rcpoitetT to-have been taken l>y ^ Baibary l*"atc. and ca.ri.ti into Atricrs, is arrived tic:c \t:i>-g 10 cx:in-U^dit, the Heads of ihc Conipiiacy were 10 nave caas'd tor. 8co artncd Pcafantf to Lave enter*ti >he City, eichcr tf ^Surprize, or under Pretence 01 *lli:'ing to extin^uifii fiJ^^vcK, who were 10 have been joined by the Coalpira-(m-in the City ; tt they hare made b ce the Year bomg rciaiburs'd the Su.tu they paid for them, and the thargcj they have been at in improving them. 1 ne Dcii^u ol ihi^ Ordinance :s to prevent thelc Cunvent . &c. Iroin becoming too powerful, to the Pnjudice of tiic Laity, and the Kcvcnue of the Court. Berlin, July 19. On the i^thMaifliil Saxc faw fcvcral Regimenls excrcifc at I*o;iJani, whofc Bc2u'y \ti :tr;/ he very much admind He atier-.vi>rds dined ui:.. :i c King at his Palace callJ C,u.i-Sanfy. We ILutercd ouii.lvc^ that Count Saxe would h:�vc ini.tlc a longer Stay tviiii u�, hut on the lyih he dcpertcd, with Icveral iVfioiis o* DiitiniUon in his Retinue, in order to return to DniJen. Brnffdt, July to. An �n^li!huian ciUbliJhed in this City, tvai taken up iitll Week, and fent to Pnlon, being accufcd of having fcrvcu ilic French as a Si>v, during tbc MWar. LONDON According to the Acco-jift received z\ Rome of the ConfpiraCy again.l Malta, it was formed by the Bachi of Rhodes, who was carried in Pmbocr dicre loiUe Time aijo : He bad brought into his Dciign all tlic Slaves in thelfiar.u, to the Number of 15300, who a certain Hour were 10 maflacre each his Waller. They expecled to meet wi:U little Difficulty in making theailctve^ Matters ot the Uland, > it is ill fortified, many of the Knights and Suluiert uuc Crulzinij, and were aiFaied of fpcedy Aiuftancc from the Algeriucs, vwho had been let ir:a the Plot. It was difco Ver'd by a Greek, who un icrflood the Turkilh Language, and overheard a Conveifa ion of fome of the Riojlcadus. Other Letters fay, that one of ihefe Ui^ iia\iug fccurctl lu hiotfelf a Patdun, bcia^ed the whole to the Cr>i:d Mailer when it was v.-ithin eigh*. Mours of bcii.g j>j: in Fxecutii*� By a Letter frdin ope ol ifcc Gentlemen �.: l^e Orkney* feat out in the Baltimore Sloup, Capt. Walker, to I x upon proper Place* to eilabhiU the Fiii.cries, �e are informed, that feveral i'lans of Places had been taken, and wuc thea ttadcr ConUdcraiiou ; that ihxec patiivwLu PLiui 1^1 been ��'(^'icd or, and up^vards of Ms Perrons �.crc eigigtd i-. Iciclirng the Giaund, and tnjkug l"t!"|>.>:i ady ftU'd i and that t.ic in geiutai fcfm*d traafjjoitid wi;h Jo;.- in Evpo.M.c.trri n the great ticncfii It unduub cd'y in..;l be to \S.,jlt Kin>i.jm ^V'e are ali\;:v-l, i.ijt N;en uf VVjt o! \%-\y. iti-i three of l�er.?v Gu >�, v�i� be il*.i..n d on �}'..�t v.i...l. ut tvhOm arc to be Lru.^crs, lu oidcr to >..v't .,>' c F:ili^iies in th.ir infaiicy, Lnd give ihcm pi.j-o' 'a ci. Hi, Majcily has bicl�iu'f* .imoiij; them, a.td to t.-ikc 11. a much grtarcr t^-iinnty ot Prov i-fiv'iis an� Stores for the Utc ff the Seiiirrs ulreadv j one there, and to t.ike on board alfo a Conb.Ur.d le rvimnbcr ot Scotch a.id lulh, who have pciitioii'd thiS Loid� of Tr^e and Plantations fur ilm 1V> jxrfc. Yctlcrdiy his ExCvlloncy the Ma:qlis de Minopei.v had a great Levee at his \\ efc i-j Gu�lvc(ior-Sq'.:aic. n.o.*l of the foreign Aii.baffadots being tiinre to �ilit hi� Kxc;liency. His Servants make a vrand Ap;^�rai^e, their Livv-ries b.-ing icariet laced With &ilver. Yeftcrday his Geacc the Archbifhop of Canterbury rcarov'd from I.is Hcv-fc in KojiUcgto.i-Squire to his fahtcc ar Lambcii), to rciide there l".a ly this Moining .he Cofps of the la;c P.Ue r>f V'oi.ugj-was-xarrtcd from ht*-4�fa�;-j--44T?a>o in i'rivy ' G.iKfcrts, ip otJer to be intend .^incii^il his Aiiceilois ut bou^hJrii m Northaii'po. llirt j the Corps uill. it's taid, lu; �;ci l.-a: t'lacc by up.vards ol ;oo of his v, i ace s Tenants A Prefcntftuoa pafs'd the Gre.it Scd. fir the Rev. Leoaard lloivard D. U. of the Rrclory of St Gvorg^, Souili.vark. hv. ... prcfcnt.d thereto by the iloa. ttic Lo.-d High taaav.tl!or. Ytlkrday Ilorni^ig was married at the P.triflt Cliuich of ^t. A. il;: �v Ho'boru. Mr. W alsh, c-f Thf jadn. ciilc-i'lr" to Mifs Pcarce. of Cnaunjj-Lrofs: an .igrtvabic )ou)ig Lady, of great Ment. and uptvUrds of ol. On S-Joday d)ed at his Hnufe at Hadley, Mr. 1 humas Chandler, forratrrly an eminent Lianrn-Draper in Hia>v-Kadder-Strect. Ycllcrday Morning an Ox. over heated by driviDg, X'A great Damage to fcveral Pcifoos; in Chcajfidi: h; wlf^d a Gcntieman that v/as croUing the Way, and by the .Mauiian Houfc he gored ar rldcily Woman, and toifvda Gfnd.ai^n v.ith fuch Violence, that it was ibungM ibe t.�o bll could not pofiibly get over the Hurt ihcy rccciv'J, more particularly ttie Woman, who was got d in U�o Ceatl. Oo Sniuby Itvcuing. a Man in a Scaf.iring Ortts was found call on tiic l>4)Oie by l.iaichoufe i in his Pockets were feveral Guineas ar.d fome ."^lUcr; and by fome Papers fuund about hiin. it appear'd il.at he wajr,lj;ciy diKhargtd from the Cornaall, which artivd a few We^s fther io the Head and Ptiroat in (o dangerous a Manner tb^t her Life is defpair d of She was direflly t'ccur'd and cariied bcfoic Jullice Fielding, and by him committed to BiidencU. I iie tw� Tl ie\cs who n bb'd the Footboy by Sadla's Wells, Ifli-^ton, !all Friday in tbc Afte noon, and were lodg'd in New Prifon, found .Mcaiu to cfi-ape the fame N ijjnt. On Saturday Night a Soidicr wa; taken in Whitrch.nptl, and coRimuicU 10 iha: C>aol. for llcabng a Silver hilled Srturd out of liie Ili^etc of Col. Lalcrl!.:* in the Tower, at the lime of the fif� which haj'pcned there on Friday Moriiin^. Ve.'.crday Moitii g another SoMicr was taken in Cheap fide, a? an Acat were tiied for taSiinor p from a Uuich Ship, cail.d the lioop, laicl' llraudcd ou Po(t'.�ful-Bc4Lb, arc aci]ajii.;d Uooy Corr.cli.ir, of .AmUcrdani, was Ca, lain. Biijicl, July .5. On i tiuiiJay twenty-fcvcn Pcif>ns conf.n'd far lJci�i (under lul. caciij id Ncwgne, wuc dii'cha'g'd, tbiu'.igh tUe chaii,�blc and C'liriiUan fieuc-volctce of ihtf Rij;i-.t Honour^tl/lr lueCoutittfs of Huoung-don 'i'hcre arc fe^cn utlur Diltiuis, and icvrn Pvrlons (detained for ihur f:w.'Je be dilckirged tt.roug'> the f.mc i.obl� Dil'pofuion and Bounty. Elnk^irgh, July 1 1. Y^llerJjy nas rcfunied, before the ju^l Ciary C�u(i li^rr. i!.c (Hal ot job" t>nii h aid I'Iki iaa:> BrauihAV/, ioiaicilji nici-iioiicd, lor eauiaei frtii�{> the current Com of ih>> Ki.alin. wl.ci: two B-lb ot lutiK'luicni wcrv prtfcired aginil SxiMt 1, cnv' lor eounici(. 1 ii.g itiv C�li>, aud the Otr.it iji ti-i.:..^ lJlf.i i^i the (. mc ; k>hcn after fevc.al Wumif.s were raaiLiiicd. ll.c July having inc'ofcd for fome I'lu'. rerurt.d a U.iiu in a a^aliill fa:d bn>iih for toon'.cifciui'g i!.. Cvm. b^t an I|;uo;amui aa to m-ki.ig the DiCi. r^oiU"^ u >ct done k.uh lajxd to Bxadfhaw. ..V,!.l i;� j oor tinfortiinafv! U btorr 01 tUa Cv>ni.iuin m ii'iier; tin, P.r.ijfafh, purcl) for S.iccour and Kc� l.t;. i>.tiig nov.' more f, r.lir.id fioji Air tlian Pelotu ; ihroi^h v.iiuli wo ur^' (lipiiveJ of l)r^(; .till', at ilic Riqjvll ot icvorqil ol iJic Nii'ilny an! lii-ntry, T'liiiotrow vi.l be n 11,^11 Uicak'aling i;ir tho If :>iaiiin_'. Part oft 'C .Sptiou Will be oit Tucfeays^ and M-ifuk foi Damiiigyi ufual, Ihc lin-crtaiiiiuc i.s of Ol,pur's GarcU'ns. Will contintt4 thi*tn�ti cvciy r.voiiitlij >_uriiij^ [h^'^aiV.oicr i5��( i vv.VhJit kM^I coiiiill it a coinujoic I'.i.td of Mufiik: Th�: Miifu'lc dividcvl ino liireo Art�, two Songs beuvreh eavh Art hf S:^,not.r Sv billa ; .ind ilw vvliolo 10 cutKlddi; will) neW .ind biv.sitif.il !,^irc%votk^, t!ic fiat ever c.xidbUcd in PiibHckc The L>o.->ri vail be opened cx.'dily at Five oVl^ik, alttl gicat Care will be taken to keep out PeVrons Pt* ill Repute,., At tic iS'iVV Vvclli in t,UHnlman's I'li^.ldf, ihiy Fveuing, will be ftvefal iv.'w I'erfon-innccJ by ^''i i>i". J'artfe/.ami Nir. nfiKl,i^.k, .>nJ fi;vi.i,il new Dances \>f hlr � J.>;j Gia- ' nicr, .Mif> Gra'ier, I'r. Mile*, Mrs. Mihi;, 4nd otIicrSi Mr. Rooker and Milt Agnctta will I'lni', f;vtr.tl t^c\K,Spngt. Tu-:b'ing. by Mr, licidrak, Mir. Tmiley, Mr JsntiO* Mr M:!c�, and uhcrs J o ivhich will be adv.td, WKUfan Ho'diy, or H.rrlcj]jin at Greenwich Tha whu'e ti coiit.li!d* [I c F i.iinpli* uf Peace- Eaeh Action to be liyniittcd for a Pint of Wine or Punch. Ai Sadler's Wc'.U, l!l-.�gton. this Evening. Mr. HenifAirk, M � S,iii.!i, and Mif- Lowe, will ling feycral new Sonps 1 \�i;h \'.Mir,y ol new Da-^ttrs by Mr. Harvey, Mr. Vnndcf-ll.iys. . ?iri Baiter. Mfi. Houf,h,. aiid other*. 3evc/al ne�r fruk' in Tunibltng. by Kir. Do�intque. Mr. WilUaw*,-Mr. I'cJro, and Mr Frances. The whole'0C3Nctud 7 ..'''ll*. . Lottery 1-47, no Price, bank Annutiit� 17^8, u/f). Ditto 1749, iq6. Three per Ctrni. Annaities, 101 3 Sti^s li 5 8.h'. Mdlion Bank, no Price. l�i;unal�iii, no: I nci. Ro,al Affjrante, no Price. London Alluioiice, no Price. Fiiglifli Copper, 5I, {s. Seven per c'c. t Biupcror'i Loao^ no Price, five per Cent, ditto, no Price. B^nk Cuctl* lation, 5I, ics. Prcm 1ml a llondi 4I 3� 4*-___ M I D 1) I. iL- Gr'irra/ :i^ii.'it,i Sfji" r/ t/.c I'ltiif 0/ tnr Scvifnirit Lii.l fl'f Kiiiy, l>-i^uJ/am l.Unth 0/.l^i-il, ill tbt i'l.ii ifjrtfuid. i\nJ uu ihifumt Dty h'-h'ily /.Jyuinmit.t .It liin. llull in St JchlliSlUst, im i.njj'j/ rl), j.iiJ L:uiiy, Il>u/nm Lntic, A'/yj Sir Jata i ll..rt. Jil'ii A.ilrur JiiMiri CJitKroiK, l.ukt Rtjiin/j-!i:ie dizen F.lj'do, lrtj/ajfit, umt il/jcr MiJ'dtcdi ihit:iii:tidi/i litfami County: IT btiiig irprcfenttd uut > this Court, that feveral e( ii.ni>>ii I'layert of Jh'crludes, Gameilers. and other IojI.-, lolc and diforduily Perloin, have for feveral Vear� 44.;d and ac^ulloined to jiB>.iiible iriid matx icgethvt at l� .eial fair, or prttcude�l I'liri, held in this Cotiniy of Middlifc*. nut warraiurd by Luw, 10 wit, Tottenham* Ccurt Fair, I'ampdcad lai , and Paddington Fatf ia Ho.buin Divift o, ho jhcpi'cid's QuQl Fair in KcnGrgoa Oiviiim, the W.tvh t'.ar in I'liiitur) Ofv fion. Milf:-I^nd Fair, and Buw I'air, commonly call'd Green G' fe fair, i 1 itic Towtr Divifjnn, and Miiy F-r in W^HjniuJKr DiMiion i fome of winch i an* contini.c for a I''ort..ig r, and uihris lor Thr.c Wccki, andMlio-.- ^rjat Numb;'> v.f PiO>le flay till One or TrtO of the I Ixk lU Uie Morwi j.; And fucb Pl.i)rM of Jiitriladbs and o(iion tiltfiA to Contf^l^l IvT GroaiJ, aud ihcreiipjn bu'.li Booths aud ^^hed>, v%here ti.ev have a.lied lucti I'ljys at'd Dru Ij, and csrrvtd on ari ct'ioui.,ged divers kr^Js of Unlaw/ui I'lay and G-nii'g. wuich haJi uiAiiilvil'y i.nd�d (g (hf trfiwoiaia^eixcn: ^ ;
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BMW Forum - BimmerWerkz.com (http://www.bimmerwerkz.com/forum/)
- Z3 / Z4 /ZM (http://www.bimmerwerkz.com/forum/z3-z4-zm/)
- - New Z3, where too start tuning? (http://www.bimmerwerkz.com/forum/z3-z4-zm/new-z3-where-too-start-tuning-75676.html)
New Z3, where too start tuning?
Hi guys, I pick up my 98 2.8 roadster on sat. It's got 48k on the clock.
I want to start tuning it up pretty much straight away. New wheels first. What's the best size to go for? Obv I want wider at the rear but not really sure what size to start looking at. It's gotta 'look' good over performance!
And where is best to start with engine mods.
I'll post pictures as soon as I get home to laptop...
What are your overall goals for the car?
Do you plan to track it? or Just trying to build a fun daily driver?
Give us a little insight about what you use it for and we can give you some better recommendations about where to start!
Congrats on the new purchase by the way and welcome to the site!
Hi, it'll just be a weekend cruiser. I plan to fit subtle body mods, lower it slightly. Fit a fat set of shiny wheels and then get set on making it go faster. I won't be using it for track days... Ever! Haha. The wheels are my first change. How big can I 'sensibly' go? I want to be comfortable when I go out.
I'd recommend 17" or 18" wheels anything more than that and your ride quality may start to suffer.
We also have tons of options to lower that car too so give us a call when you're ready to drop it right!
Welcome to Bimmerwerkz!
Before you start modding the car too excessively how is the maintenance on the car? All the fluid changes up to date? How are the bushings? Rear Shock Mounts? rear Trailing Arm bushings? Before you dump a bunch of money into flashy wheels make sure your not going to have something break and leave you stranded. With any "new" car you should give it a thorough look over.
As for wheels, the lighter the better. 17"s are better for performance, 18"s are just for looks. A 17" rim and low profile tires will retain the same tire profile as stock so you won't have to have your speedometer adjusted. 18"s are heavy and require a fair bit of energy to spin taking away from overall performance. And will also increase stopping distance slightly. More wheel to turn is also more wheel to stop.
'18"s are just for looks.'
18"s it is then! Haha.
Thanks for that Vader. That is sound advice. I will drive it about for a month or two to she how she runs and get a feel for her before spending out like you say. I'll also be putting her in for a good service and thorough check over with my mate the BMW god.
I'll let you know how it all goes.
Be advised though, that of you get the 18"s you may have to roll your fenders. I have 18"s on my E36 and they rub the fenders when cornering. And I have 18"s cause the store I ordered them from screwed up and ordered me 18"s instead of 17"s. I didn't novice until after they were installed! I don't track the car so I jut kept them.
Great advice Vader, maintenance is always super crucial with BMW's, especially the cooling systems, keep an eye on that fan and thermostat housing. As long as your on top of proper maintenance the cars are always a joy to drive.
I have 18x8.5 on my e36 and mine wont rub under hard cornering or while autocrossing, but like Vader said i have rolled my fenders ever so slightly. Its not really difficult to do with the right equipment..
I actually really like the way 17's look on these cars too but it basically all comes down to how much you lower the car and the tire size you go with.
I lowered my E36 with Koni springs and shocks. About a 1"~ drop. It rubs but not that bad. Enough to make me need to roll my fenders. No drop and they har no issues
I should point out that I'm pretty cool with any work that needs carrying out. I've been an engineer for 15 years haha. Was more thinking about order of engine tunes. But knowing I'll have to roll the arches for 18"s is deffo worth knowing. No real biggy but might be worth just going 17". I'm also going to build a mould for in between seat sub mount as that'll be easy to do at work. Also been looking into the whole double din stereo issue. Should be a way around that I reckon...?
Engine wise theirs a fair bit you can do. It shares the same 2.8L M52 engine that's in the E36. Examples are CAI, exhaust, under drive pullies, M50 manifold, fan delete, S52 cams, conforti shark injector/tuning.
2 Attachment(s)
Here She is...
Looks great! It will be nice to see how you progress with her
i just got mine sat too 99 z3 coupe 98k and im loving it:)
its got 19s on it and im not sure about them but ill let you take a look
The black rims look great! How is the ride with the 19"s?
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LifeBridge Health is a regional health care organization based in northwest Baltimore City and Baltimore County, consisting of three hospitals...
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Situated opposite the rapidly expanding Tianfu Software Park, the Hilton Chengdu hotel is within 10 minutes of the New International Exhibition & Convention Center, and offices, shops and entertainment in the New Century Global Center. Chengdu Shuangliu Airport is just 20 minutes' drive from the hotel, and we are only two minutes' walk to the exit of Metro Line 1, which connects to the city center.
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- the close of business on March 14, 2014;
- the time at which these rights are redeemed or exchanged under the Rights Agreement;
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- such time as Capital Trust's Board of Directors determines that a limitation on the use of the Tax Benefits under Section 382 would no longer be material to the Capital Trust; or
- The issuance of the rights will not affect Capital Trust's reported earnings per share and is not taxable to Capital Trust or its stockholders.
NEW YORK, March 3, 2011 /PRNewswire/ -- Capital Trust, Inc. (NYSE: CT) today announced that its Board of Directors has adopted a tax benefits preservation rights agreement designed to preserve certain of its tax assets (the "Rights Agreement"). The Rights Agreement is similar to tax benefits preservation rights agreements adopted by other public companies that also have significant, similar tax assets. By adopting the Rights Agreement, Capital Trust's Board of Directors is seeking to protect Capital Trust's ability to carry forward its net operating losses and certain other tax attributes (collectively, the "Tax Benefits"). Capital Trust has experienced and may continue to experience substantial net operating losses for federal and state income tax purposes. In general, Capital Trust may "carry forward" net operating losses in certain circumstances to offset current and future taxable income, which would reduce federal and state income tax liability. However, if Capital Trust experiences an "ownership change", as defined for purposes of Section 382 of the Internal Revenue Code of 1986, as amended, its ability to use the Tax Benefits could be materially limited. Generally, for Capital Trust, an "ownership change" occurs if there is a change in ownership of more than 50% of its common stock during any three year period. For this purpose, determinations of ownership changes are generally limited to shareholders deemed to own 5% or more of the Company's common stock. Effective today, if any person or group acquires 4.9% or more of the outstanding shares of Capital Trust's common stock (subject to certain exceptions), there would be a triggering event under the Rights Agreement resulting in significant dilution of the ownership interest of such person or group in Capital Trust's common stock. As part of the Rights Agreement, Capital Trust's Board of Directors authorized a dividend of one right for each outstanding share of Capital Trust's common stock. The rights will be distributed to stockholders of record as of March 14, 2011, but will only be activated if triggered by the Rights Agreement in order to effect the aforementioned dilution. Capital Trust's Board of Directors has the discretion to exempt any acquisition of common stock from the provisions of Rights Agreement. The Rights Agreement may be terminated by the Board at any time prior to the rights being triggered. The rights will expire upon the earlier of:


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Google slashes Nexus 4 price
Google has slashed the price of its Nexus 4 Android smartphone by $100 in Australia, fuelling suggestions the device is due for an upgrade in the near future.
Google has slashed the price of its Nexus 4 Android smartphone by $100 in Australia, fuelling suggestions the device is due for an upgrade in the near future.
LG's new white Google Nexus 4 will be sold "exclusively" through Harvey Norman from mid-June, the company announced today.
Leaked press images have all but confirmed that Google is set to launch a white variant of its Nexus 4 Android smartphone.
Google is once again taking Australian orders for its hard to come by Nexus 4 smartphone, after selling out of the device for the second time last week.
Google has exhausted stocks of its Nexus 4 Android smartphone in the Australian Play Store for a second time, just hours after the device went back on sale yesterday following a two month long hiatus.
LG has today announced that its Google Nexus 4 Android smartphone will be available "exclusively" through Harvey Norman retail stores from Friday 1 February.
Google has exhausted initial stocks of its Nexus 4 Android smartphone less than an hour after the device went on sale yesterday.
Although Google had to call off its formal Android event due to a historic hurricane slamming into the Eastern Seaboard, all of the major announcements it had been planning were nonetheless made online.
The latest business news, reviews, features and whitepapers
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HP OfficeJet Pro 8730
A smarter way to print for busy small business owners, combining speedy printing with scanning and copying, making it easier to produce high quality documents and images at a touch of a button.
HP OfficeJet Pro 8730
I've had a multifunction printer in the office going on 10 years now. It was a neat bit of kit back in the day -- print, copy, scan, fax -- when printing over WiFi felt a bit like magic. It's seen better days though and an upgrade's well overdue. This HP OfficeJet Pro 8730 looks like it ticks all the same boxes: print, copy, scan, and fax. (Really? Does anyone fax anything any more? I guess it's good to know the facility's there, just in case.) Printing over WiFi is more-or- less standard these days.
HP OfficeJet Pro 8730
As a freelance writer who is always on the go, I like my technology to be both efficient and effective so I can do my job well. The HP OfficeJet Pro 8730 Inkjet Printer ticks all the boxes in terms of form factor, performance and user interface.
Windows 10 for Business / Dell XPS 13
I'd happily recommend this touchscreen laptop and Windows 10 as a great way to get serious work done at a desk or on the road.
Windows 10 / HP Spectre x360
Ultimately, I think the Windows 10 environment is excellent for me as it caters for so many different uses. The inclusion of the Xbox app is also great for when you need some downtime too!
Windows 10 / Lenovo Yoga 910
For me, the Xbox Play Anywhere is a great new feature as it allows you to play your current Xbox games with higher resolutions and better graphics without forking out extra cash for another copy. Although available titles are still scarce, but I'm sure it will grow in time.


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SteelSeries developing eye-tracking controller for gamers
Gaming accessory maker SteelSeries has partnered with Tobii Technology to develop a device that will let gamers use their eyes to control game play.
Gaming accessory maker SteelSeries has partnered with Tobii Technology to develop a device that will let gamers use their eyes to control game play.
Tobii Technology will soon start shipping a device that allows users to control a PC using their eyes. Developers will be able to buy the REX next week, and Tobii will make it more widely available in the second half of the year, the company said Wed...
The latest business news, reviews, features and whitepapers
Visit our shop for the best deals on hot products
Watch our video news and reviews from around the world
Comprehensive buying guides, features, and step-by-step articles
HP OfficeJet Pro 8730
A smarter way to print for busy small business owners, combining speedy printing with scanning and copying, making it easier to produce high quality documents and images at a touch of a button.
HP OfficeJet Pro 8730
I've had a multifunction printer in the office going on 10 years now. It was a neat bit of kit back in the day -- print, copy, scan, fax -- when printing over WiFi felt a bit like magic. It's seen better days though and an upgrade's well overdue. This HP OfficeJet Pro 8730 looks like it ticks all the same boxes: print, copy, scan, and fax. (Really? Does anyone fax anything any more? I guess it's good to know the facility's there, just in case.) Printing over WiFi is more-or- less standard these days.
HP OfficeJet Pro 8730
As a freelance writer who is always on the go, I like my technology to be both efficient and effective so I can do my job well. The HP OfficeJet Pro 8730 Inkjet Printer ticks all the boxes in terms of form factor, performance and user interface.
Windows 10 for Business / Dell XPS 13
I'd happily recommend this touchscreen laptop and Windows 10 as a great way to get serious work done at a desk or on the road.
Windows 10 / HP Spectre x360
Ultimately, I think the Windows 10 environment is excellent for me as it caters for so many different uses. The inclusion of the Xbox app is also great for when you need some downtime too!
Windows 10 / Lenovo Yoga 910
For me, the Xbox Play Anywhere is a great new feature as it allows you to play your current Xbox games with higher resolutions and better graphics without forking out extra cash for another copy. Although available titles are still scarce, but I'm sure it will grow in time.


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Save.ca has a great new coupon available for you to save $4.00 on select Asprin products.
*Available by Mail order
Click here to request this coupon from Save.ca today!
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From Our Editors
The Holy Cow's electrified hues of blue and purple cascade across revelers dancing and drinking inside the upscale nightclub dappled with chandeliers and private booths. Live DJs provide an ongoing cadence for dancing or rhythmic staring contests, and Sunday evenings unite patrons with live-house-music parties hosted by Honey Soundsystem. The Holy Cow's full bar can provide premium bottle service for parties of up to 10 guests, and its semiformal dress code aims to keep crowds in articles of their finest revelry regalia, such as collared shirts, clean shoes, and neon cravats.


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Need an IgE Blood Test in Cottonwood, AZ? Simply order online 24/7 and get a fast, affordable IgE Blood Test at a lab near you (Find More Locations):
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OpenSUSE Seeks Successor for ATI Driver Script Maintenance
Developer Stefan Dirsch is responsible for maintaining the openSUSE build scripts of the fglrx driver. In a message on the openSUSE developer mailing list, he appeals for a successor to take over the maintenance.
Users with ATI graphic cards have to rely on ATI/AMD proprietary drivers for 3D acceleration. The scripts are found in packages/SUSE when the ATI installer is extracted manually.
Among the benefits for the new maintainer are access to ATI's beta mailing list and early releases of the beta driver. The files are currently hosted in a git repository at phorox. Dirsch hopes to find someone whith not only the time to update the scripts, but who can also introduce new features.
Issue 199/2017
Buy this issue as a PDF
Red Hat Announces OpenShift.io
Red Hat takes its IDE online.
Microsoft Bakes Linux into Windows Server
Microsoft is slowly becoming a Linux vendor.
Fearless Coyote, Linux Kernel 4.11 is Out
The new kernel makes swap implementation more scalable, which will help cloud providers.
Docker Appoints Steve Singh CEO
The new CEO comes from a very strong SaaS background.
Docker Announces Linux Kit and Moby Project
Both projects help organizations build their own containerized systems.
Ubuntu Returns to Gnome as Its Mobile Plans Shatter
Mark Shuttleworth has resumed the position of CEO of Canonical.
Microsoft is Shutting Down CodePlex
Microsoft's open source code hosting platform CodePlex will come to an end after a more than 10-year stint.
Fedora 26 Alpha Released
Comes with Gnome 3.24
Old Linux Kernel Bug Discovered
The bug was introduced back in 2009 and has been lurking around all this time.
OpenSSH 7.5 Released
The new release deprecates the sshd_config UsePrivilegeSeparation option.


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Sleeps 4
Bedrooms 2
Bathrooms 2
Pets Yes
"We had a lovely time on Valentia ..."We had a lovely time on Valentia island,the property was in a good location,right opposite the harbour.If we needed anything Sandra was on hand.All in all a great holiday.
- Off road parking
- Smoke-free
- Garden / Patio
- Cot available
- Highchair available
- Pub/shop < 1 mile
- Washing machine
- Dishwasher
- Seaside
- Broadband / WiFi
Search property
The property
A delightful, mid-terrace cottage situated on the harbour in the pretty village of Knightstown on Valentia Island, County Kerry.
This beautiful Knightstown cottage is perfect for spending time together as a family or with your loved one.
Open the front door of this Knightstown cottage and you are immediately greeted by the bustling harbour and pier with a multitude of activities available.
This charming Knightstown cottage has two bedrooms, two bathrooms, and an open plan living area with kitchen, dining area and sitting area.
Outside this charming Knightstown cottage is a rear courtyard, ideal to relax in with a drink, or why not sit out at the front of your holiday home and watch the fishing boats return from the ocean, before sampling the catch yourself at one of the quality restaurants nearby?
Just a short distance from this lovely Knightstown cottage, there are impressive mountains including Geokaun Mountain, Fogher Cliffs, and the lighthouse at Cromwell Point, together with spectacular walking trails.
Just a short distance away from this charming County Kerry cottage, and running every ten minutes, you can take a short ferry ride to the mainland, or if you prefer, take the bridge and arrive on the famous Ring of Kerry, Ireland's most renowned scenic drive.
On this stunning stretch of the Wild Atlantic Way, you will find a multitude of interesting villages and unspoilt beaches.
The popular town of Killarney is within driving distance with many festivals and events, family-friendly amenities, and a selection of shops, cafés and bars to enjoy.
The picturesque National Park and Gap of Dunloe are perfect spots for a bike ride and golfers will love the challenging courses around the area.
Whatever you're looking for, this welcoming Knightstown cottage is a great choice for a memorable Irish holiday.
Two bedrooms: 1 x double, 1 x twin. Bathroom with bath, shower over, basin and WC. Ground floor wet room with shower, basin and WC. Open plan living area with kitchen, dining area and sitting area.
- Electric central heating
- Electric oven and hob, microwave, fridge, freezer, washer/dryer, dishwasher, TV with Free-to-air channels, DVD, CD/radio, WiFi, selection of books and games
- Fuel and power inc. in rent
- Bed linen and towels inc. in rent
- Travel cot and highchair
- Off road parking for 1 car
- Courtyard garden with furniture
- One well-behaved dog welcome
- Sorry, no smoking
- Shop, pub and beach 1 min walk.
About the location
Cahersiveen 15 miles; Kerry Airport 53 miles.
Knightstown is the main village on Valentia Island, which lies off the coast of the Iveragh Peninsula in County Kerry. It is accessible from the mainland by ferry from Reenard Point, or via the road bridge at Portmagee. Knightstown provides restaurants and Irish pubs as well as entertainment and local shops. It is also the departure point for a variety of sightseeing boat trips and fishing trips. Take a trip to the magnificent Skellig Islands, the site of a 6th century monastic settlement, and home to a large colony of gannets and puffins. With around 650 residents Valentia Island stands out as one of the westernmost inhabited locations in Europe, and was the site of the first permanent communications link between Europe and the United States. The Island is famed for its magnificent 'Fogher' sea cliffs, which rise majestically from the Atlantic Ocean on the northern side of the Island, and the subtropical gardens at Glanleam House, which are a unique delight for visitors of all ages.
This property offers the following short breaks:
- Off-season


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The picture demonstrates a sick spinal nerve. It is circled. This is the result of a subluxation. In this case, the nerves above and below are unaffected.
subluxation (sub''luk-sa'shun) - Any vertebrae which has lost its proper juxta-position with the bone above, below, or both, which impinges on a nerve and interferes with mental impulses. That is, a spinal misalignment or malfunction that doesn't allow your body's communication system to work properly.
For the technically inclined:
There are several components of a subluxation. They include:
- spinal kinesiopathology - (ki-ne"se-o-pah-thol'o-je) bone misalignment and joint malfunction such as in hyper or hypo-mobility.
- neuropathophysiology - (nu"ro-path"o-fiz"e-ol'o-je) nerve malfunction and nerve pathological changes resulting from the nerve being stretched, pinched, impinged upon, or irritated.
- myopathology - (mi-o-pah-thol'o-je) dis-ease of the muscles, seen as muscle spasms, contractures, atrophy, and/or weakness. This can cause a change in the makeup of the muscle by replacing healthy contractile tissue with fibrotic and less elastic tissue.
- histopathology - (his'to-pah-thol'o-je) changes of the involved soft tissues of the vertebral subluxation complex including discs, ligaments, blood supply and lymph supply.
- pathophysiology - (path"o-fiz"e-ol'o-je) cummulative degenerative arthritic changes that occur to the soft tissues and bones of the involved vertebrae.
These terms are used to describe the changes that take place with the involved tissues of the vertebral subluxation complex. Pathophysiology also occurs at the innervated tissue level. The malfunctioning nerves will result in less than normal function in the tissues they innervate. This means that a subluxation can cause an organ to work less than 100% and become sick. For a list of some of the effects of subluxations, please see the Chart.


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Nyx: A New Face.Mature
I wandered down to the human realm. I could sense a God down there I hadn't encountered before and the isolation of the Other realm was starting to grate on me. As always, when I decended, the sky grew dusky indigo. I settled in a quiet park somewhere, sending my mind out to find out a little more about who I was about to meet.
Someone rounded the corner, and lowered the hood covering his face. I instantly brought my focus to the figure in front of me. His crimson eyes were a tell-tale sign that this was indeed the God that had atteacted my attention in the Other. He stood very tall, and his brooding presence suggested him to be some kind of Underground or Underworld God. I flicked my psychic powers towards him and confirmed my suspicions. I also got an overwhealming sense of lonliness from this stunning yet forbidding God. I instantly symapthised with him. Us darker Gods are not the most popular bunch and tend to get chewed out no matter what pantheon. I smiled at him, holding out my hand.
"Pleased to meet you Than, my name is Nyx" I spoke softly, my voice turning lyrical.
He shook my hand with a firm grip that told me he possesed great strength. "Erm hello Nyx but how did you know my name?" I met his eyes, supressing the urge to giggle. I loved my powers sometimes.
"Oh sorry, I didnt tell you. I'm psychic." I replied, "So I knew I was going to meet you, I know you're the God of the Underground and very lonely and depressed..."
I trailed off, reading his bemusement. I had said enough to prove I was psychic. I didn't want to spook him.
"I'm the Godess of the Night... and Ive been lonely. Do you mind if we chat?" I lgave him the full force of my violet eyes. My voice had turned soft again, causing him to look down at me. The corner of his mouth flicked up in a crooked smile that made him even more handsome than before.
"Sure why not?" he replied, settling on the bench beside me. Talk drifted to our past.
"There's not much to know about me." I said. "I tend to stick to the shadows. I'm from the Greek pantheon, although not many people know that. I used to be one of the major Gods, running alongside Zeus, Hera and the others.. But Hera, grew jealous of my beauty and powers, as they outshone her own. She feared I would replace her as Queen of the pantheon. She got together with Artemis(Goddess of the hunt) and Apollo, and they together turned Zeus against me. Some, notably Hades, tried to help me but I was cast out to live in the Other. I have been there since, unable to return fully to the pantheon. I have returned before, but always seem to leave a war in my wake.." I trailed off again.
"What is your story Than?" I asked gently. "Your name is like that of Thantos...he loved me once.. Before Hera used Hypnos (God of Sleep) against him so that he would not protect me..." I shook my head. "Sorry, Than. What is your story?"


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Always on my mindMature
As soon as school ended and we got home I went to my room. I had to be alone so I could clear my head, but when I opened my door I took a step back. It was a different colour, red, just what I wanted it to be, and there was a box on my bed filled with stuff from my house, favourite books, music, posters. There was a note on top of it. Surprise! Hope you like your new room. F
It had to be him! I gave a small squeal of delight and began to spin, arms outstreached. I felt on top of the world, I was in love.
I spent the rest of the afternoon getting my stuf out of the box and putting posters up. The room started to feel more personal and homely.
Ebony knocked on my door and called me for dinner. I didn't want to leave my room, I wanted to be alone, listen to music and read, but I had to eat.
Dinner was very quiet. Something had obviously happened between Sparkle and Ryan because they could barely keep their eyes off each other. Ebony was moody as usual and I couldn't stop smiling so we made an interesting picture.
'I'm going for a walk after dinner.' I felt I had to break the silence, but Ryan was immediately alert.
'Where were you going to go?'
'Just down to the beach, I could do with some sea air.'
'OK.' I could see he wasn't comfortable with it but he couldn't stop me. 'Just don't stay out too long.'
I ran down to the pebbly beach and along the water's edge. I felt so free, I loved being outdoors, the feel of the wind on my face and the smell of the sea. I took a deep breath and started to sing.
Never knew I could feel like this,
like I've never seen the sky before.
Want to vanish inside your kiss.
Everyday I love you more, and more.
I was so focused on my singing I did hear anyone come up behind me until a hand was on my shoulder.
'You have a beautiful voice.' It was Falcon.
'Um.. thanks.' What do I say? 'What are you doing here?'
'Just came to check that you were all OK in your new home. 'He smiled. 'And to check you liked your new room.'
'I love it, thank you so much.'
'It was my honour. Would you sing a bit more for me, it's my favourite song and you sing it so well.'
'Um.. yeah...sure.' I cleared my throat, God I was so nervous, I had never sung for anyone properly before.
Come what may,
Come what may,
I will love you until my dying day!
'Beautiful.' For a moment I thought he was going to kiss me. 'Shall we go back in? It's getting a bit chilly.' I didn't want to go in but I was shivering, it had been colder than I thought. 'I would offer you my jacket but I didn't bring one.'
'That's OK, I was going to start heading back soon anyway.' We walked slowly back up towards the house as the stars started coming out overhead.


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Bank Holiday Monday 29th May we will be closed and we will reopen on Tuesday 30th May.
Buy on line or just call us: 01162404464, ask for Jackie, Chloe, Gill or Tony
-Quantity Discount! our order procedure will automatically charge at the lower price when you exceed 6 cones or more.
-Orders over £25.00 free p & p under £25.00 we charge £2.95 additional postage.
-You can register for future ordering or simply check out without registering
-Mill Shop in Kibworth. Mon-Fri 9-4pm, Fri 9-2pm Sorry closed weekends.
-Need help or advice?..we love to help if we can, please call 01162404464 or e-mail. email@example.com
-Export..we sell worldwide. Within EEC our order process automatically calculates carriage. Outside Europe, carriage supplements vary but as a guide add 20-25%, When you order we will calculate the exact extra carrage cost, contact you seeking permission to proceed, and unitl you approve this we cannot proceed with your order.
-Do you want to pay in Euros?if so ,when you place your order on-line, write in the special instruction box,"I wish to pay in Euros" and when your order is ready we will contact you with the Euro value, and will ask you to pay by Bank transfer or Paypal
-No order is charged to your card until the moment of despatch.


text:
Need an LH Test in Thompson, CT? Simply order online 24/7 and get a fast, affordable LH Test at a lab near you (Find More Locations):
What is an LH Test?
The LH Test, also known as a Luteinizing Hormone test, is a lab test that measures the LH level in the body. The LH Test is used to help guide fertility decisions for people in Thompson, CT.
How much does an LH Test cost?
Our LH Test price includes the doctor's order that you need to get tested in Thompson, CT, all lab fees and taxes, and a pdf copy of your results. For current prices, CLICK HERE.
What does an LH Test report look like?
For an example of an LH Test sample report, please CLICK HERE.
We are delighted to offer the LH Test in Thompson, CT.
LH Test in other cities near Thompson, CT:Abington | Danielson | Dayville | East Killingly | East Woodstock | Fabyan | Grosvenor Dale | North Grosvenordale | Pomfret | Pomfret Center | Putnam | Quinebaug | Rogers | South Woodstock | Woodstock


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Seiko Solar Ladies Watch - White Dial - Stainless with Gold-Tone - 50M WR
A classic two-tone design, this Seiko Solar watch features a versatile white dial that is perfect for any occasion.
- White dial with gold-tone hands and markers
- Stainless steel case and bracelet with gold-tone accents
- Hardlex mineral glass crystal
- Bracelet features a push-button release clasp
- Water resistant to 50 meters (165 feet)
Because we are authorized Seiko Retailers, you will receive a US Seiko 3 Year Manufacturer's warranty with your purchase
In stock items ordered by 4pm Eastern time ship the same day.
All orders $50.00 or more qualify for FREE UPS Ground delivery. Watch orders $149.00 or more qualify for FREE UPS 2nd Day Air delivery. Please note that FREE 2nd Day Air Delivery does not apply to clocks.


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It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is discretionary but will greatly enhance your chances of your profile being viewed by interested members. Write a few sentences about yourself, your interests and upload your nicest photo of yourself.
Utilise our website's advanced search to spot over 60s members who match your desired criteria. Or just flip through listings and spot daters that you find attractive.
Identified someone who looks right? Send them a word or two or just a wink and see how you get along. With a little luck you'll be on your way to uncover your soulmate.
It'll only take 30 seconds


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2 Recommendations
embrace-hope's recommendation
Purple, Kat Von D, & Eyeshadow. What else could you want? Stunning on Green or Hazel eyes. =)
I love all things Kat and purple. Is it good eyeshadow? I was thinking about buying it in Sephora the other day.
- lahutter
mellietastical's recommendation
I can't lie, at first I was slightly disappointed with this shadow. I didn't feel that it gave up enough product when I swiped my brush over it. Then I realized that I was probably being a moron and not trying hard enough to get product. Personally I think the monogram slightly gets in the way of product retrieval. After I finally figured out that I needed to try a little bit harder to grab product, I wasn't so disappointed with the product. I like how the two different finishes on the color can take you from both night and day. I own Groupie and Riff-Raff and am looking to invest in King Cobra in the near future.
My Collections:


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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is voluntary but will drastically boost your chances of having members look at your profile. Type a little about yourself, your pasttimes and upload any nice photos of yourself.
Use our website's advanced search to uncover members who match your desired criteria. Or just browse through listings and uncover people that appear interesting.
Discovered someone who ticks all the boxes? Send a message to them or just a wink and see what happens next. With a little luck you'll be on your way to finding your perfect partner.
It doesn't take long


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Chapter VII : Daphne - The Right Place to Look for a Friend ☷
Chapter VII
Daphne - The Right Place to Look for a Friend
The air was cool, scented with touches of the nature that surrounded Daphne as she sat still on the ground, experimenting with her injured foot. Almost two hours had passed, with no avail to Daphne as she'd been trying to hop around, or move an inch but everytime she tried, it would only hurt further.
Sighing, she muttered to herself in a tone of disappointment, "What have I done?"
She'd been overconfident, thinking that fending for herself would be much easier. But she'd under-rated everything. Her plan had been an epic failure - leading her to the last place she'd thought of ever going to.
Excluding the fact that it was rather peaceful, and quiet, and unusually comforting to her - she couldn't push the fear out of her mind that some rabid animal might come and tear her limbs apart. Or the scenario of her slowly wasting away in hunger.
This was no home to Daphne, she had no idea where to go to get some food that won't have her skin break out in rashes.
If only I had a friend...
Sighing, she rested the back of her head against the tree, and looked up at the wide branches, past which shone the moonlight. The 'lord of the night', as she personally referred to the moon, was high in the mass blanket of darkness. It appeared larger almost, rounded. She admired its beauty, and smiled to herself.
But then, out of nowhere, popped a small brown head.


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The Rick and Tracy Ellis Show
Saturdays 4pm-5pm & Sundays 10am-11am
Rick & Tracy Ellis have been in real estate for almost 20 years and lived in both St. Louis & St. Charles County for over 40 years. Rick & Tracy have been together for 30 years, have 4 Sons and a Daughter-In-Law. Tracy is a member of the RE/MAX Hall of Fame and The Rick & Tracy Ellis Team are ranked #1 Team at RE/MAX Edge in Chesterfield and have a 2nd office in St. Charles. Tracy has been recognized for her success by RE/MAX, LORE/Real Trends, Who's Who in Luxury Real Estate, St. Louis Post Dispatch & Suburban Journals. Rick & Tracy also created and publish their own luxury magazine, "Tracy Ellis, A Guide to Luxury Real Estate". You can find the magazine distributed through out over 100 businesses in the St. Louis & St. Charles County area.
To learn more about The Rick & Tracy Ellis Team watch this short video!
TErevisedpic from Split Media on Vimeo.
The Rick & Tracy Ellis Team realize the importance of marketing their listings to the largest possible audience and that is one reason why they started doing radio shows over 5 years ago. Each week Rick & Tracy are joined with businesses in the community, celebrities and charitable organizations. Tune in on Saturday's and you'll hear information about home trends and home improvements with co-host Sandy Miller from FOX 2 NEWS. When you tune in on Sunday, it will be a whole new show discussing buying & selling real estate with special guest such as; Vinson Mortgage and Flat Branch Home Loans.
BUYING or SELLING a home is one of the largest investments you'll ever make, so choose a Realtor who will work hard to earn their commission. Rick & Tracy are full time Real Estate Agents who pride themselves with customer service being the MOST important part of their job, next they go above and beyond with marketing and branding your home. Check out their web site at tracyellis.com to see The Rick & Tracy Ellis Team DIFFERENCE! You can always stop by their office in Chesterfield anytime at:
RE/MAX Edge
699 Trade Center Blvd.
CONTACT Tracy direct at 636-299-3702 or Rick at 636-699-2197 or visit their website to search ALL homes in the MLS at tracyellis.com.


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I'm going to have Buffy watch this video over and over and over until she's inspired to have her teeth brushed, too. Buffy would bite the fingers giving her a taste, grab the toothbrush and chew it to bits, go hide in the bathtub and shred the wrapping from the toothbrush kit. Buffy does understand 'sit' and does it very well.
What's the Difference Between Martha Stewart's Mid July Garden at her Farm and Mine? - I'm finding drafts that I never published, some that I just failed to go back and click the button: How Does Martha Stewart's Garden at her Farm Differ fro...
2 months ago


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wikiHow to Make a Curled Corner Effect in Paint
Want to make a simple curled corner for a paper? Do it in Paint!
1Open Paint.
2Make a curved line. Curve it so it looks like a V on its side but not as sharp. Start the line close to a corner and end it right above the starting point.
3Make a straight line from the top of the curved line to the closest side. Hold SHIFT while holding the left mouse button and drag to the sides to make straight lines.
4Make a straight line from the bottom of the curved line to the end of the straight line touching the edge.
5Color the shape you made with the curved line a dark color, like gray. That's it. Enjoy your corner!
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- Save a template of this corner with a blank canvas. Then, when you need it go to Edit>Paste From and choose the file.
- You can also cut out the corner with the selection tool, then save that by itself. Use the same method above to load it.
- Occasionally you will find a few spots where the color won't fill. Just use the pencil tool to fix those small areas.
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Name: Aubri Ebony
Age: 23
Location: Daytona Beach Florida
Facebook: Www.Facebook.com/aubriebony
Instagram: @aubriebony
Twitter: @aubriebony
Photographer: Anthony James
IG: @so_mcfresh
1. What inspired you to get into this industry?
Wanting to be comfortable being myself and show that it's okay to be different.
2. How long have you been modeling?
Since 16 but consistently since 2014
3. Who is your favorite model?
Ebonee Davis
4. Tell us something random about yourself.
I have a stuffed animal that's a pig who's name is Gip.
5. What are you most proud of?
The fact that I'm working on my master's degree .
6. When it's all said and done, what do you want to be remembered as?
Pretty girl with a good heart. I'm definitely a lover.


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V-Day: Most men want to date Lara Croft, Bridget
Most men want to date Angelina Jolie's alter-ego Lara Croft and Renee Zellweger's Bridget Jones on Valentine's Day.
London: Most men want to date Angelina Jolie's alter-ego Lara Croft and Renee Zellweger's Bridget Jones this Valentine's Day, a survey has found. The tough 'Tomb Raider' heroine scooped the majority of votes in a survey by movie and TV streaming service blinkbox, followed by Zellweger's unlucky-in-love character at No 2, reported Sun online.
Scarlett Johansson's Black Widow from 'Avengers Assembles' came third, while Cameron Diaz as Tina Carlyle from 'The Mask' and Mila Kunis' 'Black Swan' ballet dancer Lily rounded out the top five.
Women too voted for their dream film date, with Johnny Depp's swashbuckling 'Pirates Of The Caribbean' character Jack Sparrow taking the top place. George Clooney in 'Ocean's Eleven', Matt Damon in the Bourne movies, Robert Pattinson in the 'Twilight' franchise and Ryan Gosling in 'Crazy, Stupid, Love' completed the list.
As for the romantic movie scenes women would most like their partners to re-enact, majority picked out the moment Patrick Swayze lifts Jennifer Grey into the air in 'Dirty Dancing'.
Men chose the scene showing Bo Derek jogging along the beach in her yellow bikini from the 1979 movie '10'.
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Un nido: ¡Perfecto para 2 enamorados!
My flat is in a very calm street and has a beautiful view on the Père Lachaise cemetry (trees, birds, and direct sun from midday to sunset...). It is 20 mn away from Pompidou museum and city center with the metro. It's 5mn from Place Gambetta, where you will find every shop you need for food, cinema, restaurants and bars. It is a very nice and cosy place to stay in.
Para organizar un intercambio de casa, debes ser miembro


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LIFESAVER's Michael Pritchard has been invited to be Patron of Aidex, the world's largest humanitarian exhibition, currently taking place in Brussels until 25th October.
For the second year running Michael has been invited to be Patron and use his knowledge to be a judge on the Aid Innovation challenge panel. He will also address the challenges he and the world faces regarding the eradication of water poverty.
Michael Pritchard is "honoured to play a pivotal role at such an important exhibition for the humanitarian and development sector. By talking to other experts I can share my knowledge and encourage others seeking to innovate and transform the humanitarian field."
LIFESAVER also has a presence at the show where they will be talking to key charities and NGO's about the logistical and end user burden when using current clean water solutions.
For further information on Aidex please click here.


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pond microbial culture News
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A microcosm test is conducted to obtain information concerning toxicity or other effects of a test material on the interactions among three trophic levels (primary, secondary, and detrital) and the competitive interactions within each trophic level. As with ...
Austria 4 projects (14.5 million) LIFE+ Environment Policy and Governance (1 project – 3.6 million) LIFE-URBANLAKE (Stadt Wien – Magistratsabteilung 45 – Wiener Gewässer): This project intends to define strategies to reduce the vulnerability of the "Alte Donau" from effects of climate ...
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Then sign up for the free resource list today and I'll show you 4 of the MUST-HAVE resources I've used to build my online business.
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The Mind is Out Of's entry level. Based on a classic construction that uses a cylindrical lens, it has an accessible price and it is very solid and very well ventilated.
The frame is important and protects the lens from eventual shocks, reducing the scratching probabilities.
The Smoke is a lens with a neutral smoked pigmentation without coating. It is a filter classified as S3, best suitable for nice and sunny weather conditions, but not for foggy or covedered days.
It' s perfect for good wheather conditions, while it isn' t adapt for fog or strongly cloudy conditions.
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Popular property highlights
Thunderbird Inn is located within a mile (2 km) of Animal Tracks Adventure Golf and Mackinaw City Dock. This 48-room motel has conveniences like free breakfast, an indoor pool, and free in-room WiFi. Also near this Mackinaw City motel are Mackinaw Manor Haunted Mansion and Spy Quest Laser Maze.
Start your day off right with a free continental breakfast, served each morning from 6:30 AM to 9 AM.
All 48 air-conditioned rooms feature refrigerators, coffee makers, and free local calls. Guests can expect free WiFi and cable TV. Pillowtop beds grant a restful night's sleep, and bathrooms offer hair dryers and free toiletries. Rooms also include ironing boards.
Property features
Thunderbird Inn features an indoor pool, free WiFi in public areas, and a business center. You can take advantage of free parking, along with a free ferry terminal shuttle. Front-desk staff can help with tours or tickets, and provide local restaurant recommendations. Additional amenities include coffee/tea in a common area, express check-in, and express check-out.
- Free continental breakfast
- Free WiFi in rooms and public areas
- Free parking
- Indoor pool
HighlightsInformation missing or incorrect? Tell us!Opens in a new window
Thunderbird Inn
Renovations & Closures
- Swimming pool
Hotel Amenities
Hotel Amenities
Public areas are equipped with complimentary wireless Internet access. This motel offers access to a business center. A complimentary breakfast is offered each morning. This Mackinaw City motel also offers an indoor pool, tour/ticket assistance, and a picnic area. Onsite self parking is complimentary.
Thunderbird Inn is a smoke-free property.
- Number of buildings/towers - 1
- Total number of rooms - 48
- Express check-out
- Number of floors - 2
- Business center
- Smoke-free property
- Coffee/tea in common areas
- Free breakfast
- Front desk (limited hours)
- Free ferry terminal shuttle
- Tours/ticket assistance
- Express check-in
- Laundry facilities
- Picnic area
- Free self parking
- Indoor pool
- Free WiFi
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Laundry facilities
- Playground on site
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
Thunderbird Inn offers 48 air-conditioned accommodations, which are accessible via exterior corridors and feature coffee/tea makers and hair dryers. Beds feature pillowtop mattresses. Televisions come with cable channels. Bathrooms include shower/tub combinations and complimentary toiletries.
Guests can surf the web using the complimentary wireless Internet access. Business-friendly amenities include phones along with free local calls (restrictions may apply). Housekeeping is provided daily.
- Free WiFi
- Hair dryer
- Air conditioning
- In-room climate control (air conditioning)
- Access via exterior corridors
- Phone
- Free local calls
- Refrigerator
- Coffee/tea maker
- Daily housekeeping
- Private bathroom
- Free toiletries
- Shower/tub combination
- Cable TV service
- Iron/ironing board
- Pillowtop mattress
- In-room climate control (heating)
Where to Eat
A complimentary continental breakfast is served each morning between 6:30 AM and 9 AM.
Nearby Things to Do
Recreational amenities at the motel include an indoor pool.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Cross-country skiing nearby
- Snowmobiling nearby
- Snowshoeing nearby
- Hiking/biking trails nearby
- Skydiving nearby
- Parasailing nearby
- Playground on site
Hotel Policies
Minimum check-in age is 18
Check-in time ends at 11 PM
Check-in time starts at 4 PM
Special check-in instructions:
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children 12 years old and younger stay free when using existing bedding.
- Pets not allowed (service animals welcome)
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Only service animals are allowed
No rollaway/extra beds available
No cribs (infant beds) available
No elevators
- Resort fee
Hotel Name
- Thunderbird Inn Mackinaw City
- Thunderbird Mackinaw City
We should mention
A resort fee is included in the total price displayed. Children 12 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


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Racing here at Ascot yesterday afternoon survived a precautionary inspection at 12.30pm after a morning of heavy rain. But the eight-race meeting could not beat a coded warning, apparently phoned to Charing Cross Hospital, about the presence of a suspect package within the racecourse grandstands.
Racing here at Ascot yesterday afternoon survived a precautionary inspection at 12.30pm after a morning of heavy rain. But the eight-race meeting could not beat a coded warning, apparently phoned to Charing Cross Hospital, about the presence of a suspect package within the racecourse grandstands.
Although the first race was run the warning caused the rest of the meeting to be abandoned for the day. Racing was suspended just before the second race at 2pm with the crowd being urged to evacuate the stands and make their way out into the paddock or on to the racecourse. The riders for the second race, who were already down at the start, were told about the bomb warning and then ordered to bring their horses back to the paddock.
By 2.35 all the stands and private boxes had been duly evacuated, with the estimated crowd of 6,000 being moved further away into the car parks. Shortly after this the announcement was made that racing had been abandoned for the day on the advice of the police. It was thought the suspect package had been located in the ground floor of the main stand and that the Metropolitan Police Bomb Squad had been summoned to assess the seriousness of the threat.
A discreet search of the Press Room by a steward had alerted journalists to the fact that this might be yet another race-day disrupted by the threat of a terrorist act.
Three years ago the Grand National at Aintree had to be abandoned after an IRA warning was phoned through less than half an hour before the big race. And last Boxing Day, racing at Kempton Park was curtailed by another coded warning, allegedly from Continuity IRA.
Racing is a soft target for threats such as these with large open spaces and a constantly mobile crowd. However, most punters left the course with stoic resignation yesterday, consoled not just by the guarantee of a refund but also by the sight of the new favourite for next year's 2,000 Guineas winning the first race.
Nayef, owned by Sheikh Hamdan-al-Maktoum, had been a doubtful runner according to some reports thanks to the deterioration in the courses official going from "soft" to "heavy".
But this brawny half brother to double classic winner Nashwan stood his ground in the Listed Autumn Stakes over the round one-mile course and, idling in the early stages, moved confidently clear of his five rivals in the final furlong to win by a long-looking six lengths. Nayef's previous victory over Tamburlaine at Newbury, on fast ground, had been franked as genuine by the second's subsequently six-lengths victory at Newmarket ten days ago. With this emphatic win on heavy ground Nayef soon had the bookmakers scurrying for cover as the ante-post bets rained in from telephone and on-course punters alike.
Victor Chandler offered Nayef at 10-1 just after the race, but a bet of £100,000-£10,000 soon saw the colt cut to 7-1. Further wagers began to force the price even lower and the frenzy only eased off at around 4-1. "He's a lovely horse and a beautiful mover with a flowing stride," trainer Marcus Tregoning said after the race. He'll go on anything too as he showed today. Richard Perham, who rides him at work, told me not to worry about the ground and was right."
Nayef will not race again this season and though the 2,000 Guineas is his obvious first target next year, the bookies were also fielding bets on him for the 2001 Derby for which he is now favourite at a general 10-1. Whether such a big, long striding horse can handle the track at Epsom might be open to doubt and there was much less money for Nayef's Derby prospects than for the 2,000 Guineas. "He'll stick to a mile to begin with next season," Tregoning said without outlining the colt's eventual plans. He'll probably stay one mile two furlongs and we'll gradually move him up in distance to see how far he stays."
Because Nayef is a son of Gulch, an American champion, there was some speculation (among Press rather than connections) that the colt might be aimed at next year's Kentucky Derby. The Maktoum family have coveted this race for several years now without coming up with a credible contender.
With Nayef, however, the Dubai brothers look to have a horse who, in racing parlance, "could be anything". We'll have to wait until next spring to find out precisely what.Reuse content


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Al Patra
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Al Patra Damascus
Travel Blogs from Damascus
Surviving Syria
... class)! However, the windows all had holes in them and the glass was quite shattered. I spent most of the five hours trying to work out if the holes were from stones or gunshots. Meanwhile, the train rolled through towns that were supposedly under siege, but who would know. Nothing is exposed in this country. That evening the train arrived in Damascus.
My hotel in Damascus had the address of Via Recta and while on the train I already envisaged the problems I ...
The Road to Damascus
... for 2 years and discussed a great deal about the city and Syria with us.
Besides relaxing in Damascus for a few days I decided to take a few day trips. My first destination was the crusader fortress named Crak des Chevaliers. Perched on a steep hill high above the surrounding countryside this impenetrable looking fortress, surrounding an even more fortified castle, was one of the most ...
Ramadan Kareem
... to conduct business and even in a secular country such as this, it is wise to stay away from those times and leave the hungry people to their breakfast. In such 50 degree dry weather, I couldn't imagine not eating or drinking during daylight and it is really quite remarkable what the devoted will do for their faith. Of course, tempers do flair and people get tired-we noticed in the tourist heavy souk of Aleppo, it was better and easier to shop in ...
Our "Road to Damascus"
... you see an array of wares that the locals think you may want to buy literally on the pavement. Our top three were guys selling only gaffa and masking tape, another Moulinex hand blenders, and finally a bloke who was selling just jock straps.... an interesting combination!
After our first painful border crossing, almost 3 hours of bureaucracy we arrived in Amman in Jordan. Tim was by then not in a good mood. Most of you ...
Damascus, days two and three.
... portion of the wall where Paul was lowered to escape the city.
It was a good feeling to not have to race off to a bus terminal to get to the next city.
Sleeping in tends to be a good way to start a birthday.
After breakfast, we headed over to the National Museum. Now, neither of us are necessarily museum people, but for some reason we both had enough interest ...


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La Serenaia B&B
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TripAdvisor Reviews La Serenaia B&B Milan
Travel Blogs from Milan
Visiting a friend in Milano
... lives in Milano. Una visita molto piacevole!
With perfect weather(warmer than usual temperatures) the Piazza del Duomo is filled with people, kids, and pigeons fluttering by. Even with the piazza brimming with people, the Cathedral is center ...
First Day @ Milano
... was "Hotel Bernina"
This is a simple hotel, with simple rooms, with a simple breakfast, that will do job.
If you want a pool, a breakfast with 3 miles and a runaway to put the car...this is not what you are looking for.
to be continued...
Lots of help from friendly Milanese on 1st night
... style hotel called Affittacamere Scacco Matto, was located. The ticketing officer at the station could communicate in English and we bought our tickets without hassle.
On the train, there are limited luggage compartments near the doors for huge luggage, and racks above the seats for smaller luggage. The seats are mostly arranged in fours with two front-facing seats and two back-facing seats.
But the ...
Zurich by train from Lugano, returned with Albert
... champers that I like.
We then drove back into the city for dinner at Zeughauskeller, a traditional Swiss restaurant being an old arsenal building, known for their veal dishes and sausages. There were guns of all types on the walls, crossbows, some type of Gatling gun from WWII. Veal was served with a giant Rosti (hash brown) or egg noodles. Very filling and worth the price. One of the meat dishes is served up on a sword. Very special place.
Goodbye Levanto, hello Lads.... And Milan
... that day so I knew their flight was in. We saw them from a distance and my true nature snuck up behind them and threw my jacket over Adam to make him think he was getting robbed. Haha. Didn't work as planned. I missed his head with my jacket. It was great to see the boys and we headed to the hotel chatting the whole way. Once we dropped their bags off as well, we headed to a cafe for lunch, wine and to catch up. A couple of bottles later ...


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Mental Health Cops Help Reweave Social Safety Net In San Antonio
Joyce Park stashed this in Modern problems
Stashed in: #health, Po Po!, Texas
Incredible idea from San Antonio: special cops that have been trained to evaluate and help people who are suffering from mental problems.
Wow, that's cool. I hope they figure out how to make this part of a lot of police programs!
Seems like the real magic is that all the agencies in San Antonio -- police, hospitals, jails, homeless, mental health, etc. -- pooled some of their resources to make the program work.
That's what it sounds like.
San Antonio and Bexar County have transformed their mental health system into a program considered a model for the rest of the nation:
Today, the jails aren't full, and the city and county have saved $50 million over the past five years.
The effort has focused on an idea called "smart justice" — basically, diverting people with serious mental illness out of jail and into treatment instead.


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AMD Tech Day
While AMD may not have executed well recently, they have long been an innovator, and have some interesting products launching and in the planning stages. They're bringing Crossfire technology to the notebook, even marrying integrated and discrete graphics (PowerXpress). In 2009 will have the first integrated GPU+CPU or APU (Accelerated Processing Unit).
We're excited to be in Austin, Texas at AMD's new campus for a day of presentations involving current and evolving technologies from both the marketing folks and engineers. A lot of time will be spent with their new Puma mobile platform. Sessions are also planned for graphic and chipsets, Accelerated Computing, Cinema 2.0, performance and measurements, and a facility tour. We'll be bringing detailed articles and images in future days.


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Southern California High Tech Event Calendar
|View By:
|View By:
|The Israel Conference
|Date: June 03, 2010
|Location:Los Angeles
|The Israel Conference is an interactive forum to bring Israel-facing companies together to increase business and investment opportunities between Israel and California in High Tech / Clean Tech / Medical Tech / Media / Consumer Products. The Israel Conference showcases leaders of significant businesses that were founded in Israel / have R&D in Israel / do business in Israel / and investors in Israeli companies. See http://theisraelconference.org
|More information: http://theisraelconference.org
|Download to Calendar


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And start dating


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Discovered someone who interests you? Send them a word or two or just a wink and find out if they're interested in you. With a little luck you'll be on your way to true love.
It'll only take 30 seconds


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Systems and synthetic biology approaches to cell division
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s11693-014-9132-z
- Cite this article as:
- Mashaghi, A. & Dekker, C. Syst Synth Biol (2014) 8: 173. doi:10.1007/s11693-014-9132-z
- Citations
- 1k Downloads
Cells proliferate by division into similar daughter cells, a process that lies at the heart of cell biology. Extensive research on cell division has led to the identification of the many components and control elements of the molecular machinery underlying cellular division. Here we provide a brief review of prokaryotic and eukaryotic cell division and emphasize how new approaches such as systems and synthetic biology can provide valuable new insight.
KeywordsCell division Systems biology Cellular dynamics Biological networks Synthetic biology Bioengineering Origin of life
Cell division: one of life's key processes
"Any system capable of replication and mutation is alive", wrote Alexander Oparin in 1961 (Popa 2004). Indeed, replication is one of the central features that defines a living object (Trifonov 2011). Through replication, copies of a living organism are generated. An important principle in biology is that cells replicate by division. Unicellular organisms typically replicate by symmetric division while multi-cellular organisms often replicate by an initial cell fusion followed by development of a multicellular individual through many cycles of cell division, starting from that primary cell.
In eukaryotic cells, the vast majority of the genetic material is located within the membrane-encapsulated nucleus. Next to doubling the genome, cell division involves the distribution and the organization of the chromosomal mass (in a process called mitosis) and the formation of two new nuclei, as well as the distribution of the cytoplasm among the two daughter cells (Fig. 2b–d). Segregation of the chromosomes is conducted by an apparatus called the mitotic spindle which is composed of a large set of proteins. During mitosis, the chromosomes are tightly controlled to evenly segregate so that the resulting daughter cells have the same amount of chromosomes. In exceptional cases (e.g. in the formation of sperms and oocytes), division occurs without chromosome duplication, which leads to the formation of cells with half the amount of chromosomes of the primary cell (in a process called meiosis).
While the above modes of division are the most common, cell division can also occur asymmetrically, leading to the generation of daughter cells with a molecular composition that is different from the mother (Gonczy 2008). Under physiological conditions, asymmetric cell division involves a symmetric division of the genetic material followed by an asymmetric division of the cytosol. Asymmetric division of the genetic material is typically pathologic and occurs in cancer cells.
While cell division—symmetric or asymmetric—typically yields two daughter cells, multi-daughter cell division also occurs in biology, though with low occurrence. For instance, protozoans of the genus Plasmodium commonly undergo division into three or more cells. In engineered environments, multi-daughter divisions can be induced by confinement (Tse et al. 2012). Such daughter cells often suffer from chromosomal abnormalities, so-called aneuploidy. Multi-polar mitosis and aneuploidy are frequently observed in cancer cell divisions (Kops et al. 2005; Vitale et al. 2010). Here the spindle apparatus adopts a multi-polar configuration, in contrast to a typical bi-polar structure. Multi-polar segregation of genetic material may be associated with multipolar cytokinesis, bipolar cytokinesis or no cytokinesis (Gisselsson et al. 2010).
Dissecting cell division
Timeline of key discoveries in cell division
Symmetric chromosomal division
Mitotic spindle
DNA replication
Dynamic instability
Cell-cycle control
Cdc mutants
Maturation-promoting factor
Actomyosin system in cytokinesis
The restriction point
Yeast centrosome
Cell-cycle observation
Cyclin characterization
Replication origin
Checkpoint control
Mitotic checkpoints
APC and proteolysis
CDK inhibitors
SCF and F-box proteins
Par proteins
Sister-chromatid cohesion;
In vitro assembly of microtubule aster
Min oscillations
Division genes in C. elegans
Self organization of Min surface waves
Reconstitution of contractile FtsZ rings in liposomes
Division genes in humans
In vitro assembly of centromere and kinetochore
Bottom-up reconstruction of cell cortex
New approaches to biology, namely systems biology and synthetic biology, have recently emerged that are also increasingly used to study cell division. The systems biology approach relies on the usage of statistical physics, probability theory and kinetics to understand the structural and dynamical complexity of biology at the full system level. Systems biology integrates large data sets to capture how function is generated from its components. Synthetic biology, on the other hand, involves building and engineering biological or biology-inspired components that are subsequently studied inside or outside of the cell. In this way it aims at developing a range of useful applications as well as at understanding how biological complexity emerges from its components. A common approach in synthetic biology is to build in vitro synthetic systems. Synthetic variants of biological systems provide a great opportunity to decode the constraints imposed by the complexity of natural evolved biological systems. The two approaches provide important complementary information about cell division.
Systems biology approach to cell division
Traditionally, biochemistry and molecular biology examine the properties of the biomolecules in bulk. With single-molecule techniques, biophysicists can now study the properties of even single biomolecules in details. To understand the supramolecular functional properties of living organisms, of which replication is an example, one needs to know, however, not only which molecules are involved and how they function, but also which are the many interactions between them (Jeong et al. 2001; Mashaghi et al. 2004). In the systems approach to biology, properties of biomolecular networks are studied with an emphasis on the dynamics of the molecular networks at the system level.
Another important topic in systems biology of cell division is the connection between the cell cycle and cell growth. For some cell types, the cell size increases to a threshold, beyond which division occurs (Leslie 2011). For other cells, however, there is no critical size but rather a critical growth rate (Son et al. 2012) at which cell division occurs. Furthermore, on rare occasions, cells duplicate their genomes, sometimes even multiple times, without dividing. These cells are called polyploids and are commonly seen in plants, the animal kingdom (Sher et al. 2013) and in human cancers (Storchova et al. 2006). With the development of new technologies (such as microfluidics systems with a mass sensor), precise monitoring of cell size has become possible (Son et al. 2012). Considering the ongoing systems biology research on cell growth (Ferrezuelo et al. 2012) and metabolism (Slavov et al. 2011), a better understanding of the interplay between cell growth and division can be expected in the near future. The systems approach can also be used to address epigenetic factors. Recent evidence, for example, indicates a connection between cell cycle dynamics and circadian rhythm (Kowalska et al. 2013). For example a nuclear protein is found to convey circadian gating to the cell cycle (Kowalska et al. 2013). Importantly the circadian clock is known to govern processes such as sleep, functioning of the gastrointestinal, respiratory and cardiovascular systems (Gachon et al. 2004). The discovery of the circadian gating of the cell cycle thus raises questions about connections between irregular sleep, meal times and health.
Synthetic biology approach to cell division
As one of the fundamental processes of life, cell division is of immediate interest to synthetic biologists. There are many interesting questions: What is the mechanism of cell division? Can engineering the components of the divisome help disentangling this? What are the minimal requirements for a cell to divide? Could we even engineer cellular division from the bottom up? And if so, how can we ensure high fidelity and multiple-cycle continuation in engineered cell division?
Concluding remarks
With the rapid progress in systems analysis of cell division as well as bottom-up engineering of this process, there is growing confidence for new insights into cell division, yielding hope that this will lead to better therapeutics and improved treatment of human pathologies. Cell division is impaired in many diseases such as cancer, neurodegenative disorders, cardiovascular and rheumatologic pathologies (Zhivotovsky and Orrenius 2010). Drugs targeting cell division, such as those targeting mitotic entry and the mitotic spindle, have been proposed and tested in animal models of cancer with remarkable success. An even better strategy turned out to be targeting mitotic exit and cytokinesis (Manchado et al. 2012; Domenech and Malumbres 2013). So far, none of these strategies have gained clinical success in humans, but the potential of this approach is clear. Cell division inhibitors are also obvious potential antibacterial drugs (Lock and Harry 2008). A number of molecules have recently been designed and successfully used to selectively target FtsZ, leading to division impairment and antibacterial activity (Ruiz-Avila et al. 2013). It is our hope that systems and synthetic biology of cell division will furthermore lead to new cell-cycle based therapeutic strategies for cancers, antibiotics-resistant bacterial infections and other relevant pathologies.
This special issue on cell division provides scientists with an up-to-date selection of papers from internationally leading laboratories that, through their diversity of backgrounds, help to display the interesting complexity and variety of cell division. We hope that this thematic issue will serve as a platform that will provide insight and stimulate further discussion and follow-up research. Finally, we wish to express our sincere gratitude to the authors of the articles in this special issue.
The authors are grateful to Dr. Bertus Beaumont for a critical reading of the article. One if us (C.D.) is supported by the European Research Council ERC Advanced Grant #247072 (NanoForBio).


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As the climate warms, moss growth dramatically spreads on the continent's peninsula.
December 17, 2014|
Microbial species found in pubic hair samples could help track down criminals.
December 17, 2014|
Microbial species found in pubic hair samples could help track down criminals.
December 1, 2014|
By horizontal gene transfer, an antibacterial gene family has dispersed to a plant, an insect, several fungi, and an archaeon.
December 1, 2014|
The guts of cows and termites harbor microbes that are renowned complex-carbohydrate digesters, but the human gastrointestinal tract has flora that just might measure up.
December 1, 2014|
Researchers discover a new subunit of a bacterial RNA polymerase—as well as hints of its potential role in defending against viruses.
November 19, 2014|
A murine norovirus appears to recover some of the functions of commensal bacteria in the guts of germ-free or antibiotic-treated mice.
November 19, 2014|
Researchers discover a densovirus that is associated with sea star wasting disease.
November 17, 2014|
Researchers in Europe are universally dismayed over the decision to eliminate the European Commission's Chief Scientific Advisor role.
November 17, 2014|
A single intimate smooch can transfer upwards of 80 million bacteria.
November 14, 2014|
Funding for African science; microbiome studies may have contamination worries; mind-controlled gene expression; DNA record keeper
November 11, 2014|
Sequencing study reveals low levels of microbes in lab reagents that can create big problems for some microbiome studies.


text:
Jack revealed
Footsteps moved towards her slowly. A light flickered in front of her eyes, and the visage of the guide to the underground was suddenly splattered with light, alarmingly close to her own.
For a few seconds, Lizabeth was mesmerized by the deep blue of his eyes. They looked almost soft, like velvet, as though they were something you could slide into. His crooked eyebrows drifted down into a frown and he blinked.
"For God's sake!" she scrambled backwards, brandishing her pistol. "Keep your distance!"
"Whaddya want?" he replied, scratching his unruly black hair. "I'm busy."
"I need you to open the grate to the mortuary."
"And why would I do that fer you, Elizabeth?"
"Because I'm asking you to."
She stared at him, not quite looking at him in the eye. An angry scowl sunk into her features.
"Listen. If it suits me to open it up, and it might, it'll be because I was in a good mood today, not because you told me to."
Jack shrugged, his worn tuxedo lifting and falling stiffly. He rubbed his face with the back of his hand, revealing a patch of lighter skin beneath the soot.
"Filthy animal." Lizabeth scowled at him. "Get on with it."
"You'll hold your tongue, Elizabeth Marie Renard. I'm in charge down 'ere, so you'll wait."
Jack turned his back to her and slunk off into the darkness again, his torn coattails trailing behind him.
Lizabeth let out an annoyed hiss, but sat down on the ground next to a fat-looking rat and fed it crumbs from her pocket while she waited for the Underground guardian to return.
It had been many years since she had last crossed paths with Jack. The fact that she had found him alive today had surprised her. She had known him since she was a girl—since he had been exiled to the sewers with the rest of the so-called afflicted—and never once had she seen him get out of a jam successfully.
The rat nibbled her finger gently, and she rubbed its greasy head while staring off into the distance. Jack had been her closest confidant, her only friend for four years. She had kept him alive, feeding him off scraps that had floated by in the sewage water, or rats they found skulking about near their blankets. Sometimes Jack risked going up into the daylight to find food the city dwellers had thrown into the trash, but not too often. They had seen many go, and much fewer return.
It was a number of things that set the afflicted--Jack and his kind--apart from those above. Deep eyes, the kind that hypnotize, black hair, pale skin. A sort of aura about them that made the city dwellers inch back in terror. A patience that ran deeper than seas, but an anger that, left unquenched, could prove self-destructive. It wasn't that they were special in any tangible way. They were just eerily different. Lizabeth could sense it on occasion, when she met certain underground dwellers. This feeling of foreboding, or sometimes terror, that crept up on her when she stared into their eyes.
Lizabeth, on the other hand, was neither City nor Underground. She was dead, the hired middleman between above and below.
"All right." Jack's voice echoed off the walls, his disheveled form appearing once again in the light of her candle. "It's open. But if you're going in there, I'll be takin' you."