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About the Expert
Expert Bio
Stewart M. Patrick is James H. Binger senior fellow in global governance and director of the International Institutions and Global Governance (IIGG) Program at the Council on Foreign Relations (CFR). His areas of expertise include multilateral cooperation on global issues; U.S. policy toward international institutions, including the United Nations; and the challenges posed by fragile and post–conflict states. Patrick is the author of the forthcoming book Sovereignty Reimagined: America and the World, as well as Weak Links: Fragile States, Global Threats, and International Security. He also writes the blog, The Internationalist.
From 2005 to April 2008, he was research fellow at the Center for Global Development. He directed the center's research and policy engagement on the intersection between security and development, with a particular focus on the relationship between weak states and transnational threats and on the policy challenges of building effective institutions of governance in fragile settings. He also taught at Johns Hopkins University's School of Advanced International Studies.
From September 2002 to January 2005, Patrick served on the secretary of state's policy planning staff, with lead staff responsibility for U.S. policy toward Afghanistan and a range of global and transnational issues, including refugees and migration, international law enforcement, and global health affairs. He joined the staff as an international affairs fellow at CFR.
Prior to government service, Patrick was from 1997 to 2002 a researcher at the Center on International Cooperation at New York University, where he ran two multi-scholar research programs on post-conflict reconstruction and on multilateralism and U.S. foreign policy.
Patrick graduated from Stanford University and received two master's degrees and his doctorate in international relations from Oxford University, where he was a Rhodes Scholar. He is the author, coauthor, or editor of five books. He has also authored numerous articles and chapters on the subjects of multilateral cooperation, state-building, and U.S. foreign policy.
Patrick lives in Bethesda, Maryland. He has three children.
Current Projects
Given today's global crisis, when international institutions are operating under increasing strain, the time is ripe to look back to the 1940s, when a previous generation of U.S. policymakers helped create the bedrock institutions of world order that have lasted for six decades. Please join us for a discussion of Stewart M. Patrick's new book, The Best Laid Plans: The Origins of American Multilateralism and the Dawn of the Cold War, and its lessons and implications for today's world order.


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In this week's podcast, host Josh Nathan-Kazis is joined by Orthodox rabbi, Steve Greenberg, who recently wrote for the Forward about his decision to conduct a same-sex commitment ceremony. Then Josh talks with Nathan Guttman, the Forward's Washington correspondent, to discuss how the US and Israel are trying to handle Iran. Finally, Forward editor Jane Eisner stops by to discuss why women's voices continue to be excluded from panel discussions in the American Jewish community.
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subset: commoncrawl


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I don't know the exact rights and wrongs of the dispute, though it seems unlikely that a company the size of Centrica would sign such an agreement unless it was concerned about the legal action with which it was being threatened (BT has already won one such action this year).
What I do know is that the market for home phone services is lucrative, especially for the salesmen employed by the large suppliers. Such staff are generally paid on commission, which must make it tempting to bend the rules to get more contracts signed.
We've been here before. In the late Nineties, when the Government deregulated the gas and electricity markets, an army of cowboy salesmen descended on the country, conning people into switching energy supplier, or simply transferring them without their knowledge. The scandal took years to clear up and undermined the original point of deregulation, to enable people to hunt down a better deal.
Now something similar is happening in the market for home phone services. BT faces hot competition from rivals, which want to break its stranglehold on the market. No doubt some of its fury about its enemies' tactics is motivated by a desire to retain its dominance. But BT says it gets 21,000 complaints a month, and an independent investigation by the regulator Ofcom earlier this year confirmed evidence of mis-selling in at least half the cases BT passed to it.
The scale of the problem is too large to be shrugged off as sour grapes - something sinister is going on. It is increasingly clear that rogue sales staff - with or without the knowledge of the companies that pay them - are using underhand tricks to persuade people to sign up to new phone suppliers.
The question is what Ofcom intends to do. It has told BT it must not phone customers who switch to rivals. The regulator says BT would simply try to persuade them to return to the fold, damaging competition. Fair enough, but the rule does mean BT can't check whether customers have made a genuine decision to leave, or been mis-sold.
I don't suppose BT is acting entirely altruistically in taking action against its rivals - this is self-preservation - but if Ofcom won't allow it to find out whether switches are kosher, the regulator itself should take a stronger line. In May, Ofcom was given powers to fine companies caught breaking the rules, but has not done so yet.
There's good news for Norwich Union policyholders who want to dump with-profits savings plans they hold with the insurer. It has cut the market value reductions (MVRs) on many of its funds. These reductions are penalties that savers must pay if they want to get at their money ahead of schedule - they reflect the fact that such plans smooth out poor market performance over several years, so those who withdraw early may get an unfair advantage.
Let's hope other insurers follow its lead. The stock market is 60 per cent higher than when it hit its low-point in 2002, so with-profits providers no longer have a justification for charging whacking MVRs, which are close to 30 per cent of your fund value in some cases.
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Localisation and weighted inequalities for spherical Fourier means
- Received:
DOI: 10.1007/s11854-008-0004-x
- Cite this article as:
- Carbery, A., Soria, F. & Vargas, A. J Anal Math (2007) 103: 133. doi:10.1007/s11854-008-0004-x
- Citations
- 98 Downloads
In this work, we establish certain equivalences between the localisation properties with respect to spherical Fourier means of the support of a given Borel measure and the L2-rate of decay of the Fourier extension operator associated to it. This, in turn, is intimately connected with the property that the X-ray transform of the measure be uniformly bounded. Geometric properties of sets supporting such a measure are studied.
Copyright information
© The Hebrew University of Jerusalem 2007


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Nathanial Ponn - David Ponn - Mark Ponn Cynthia Onet, Laptops And Such, Sititea-tru-ponn-corp,26 Annunciation Rd Roxbury, Massachusetts U.S.A.
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nathanial ponn, david ponn, mark ponn, Cynthia onet, laptops and such, sititea-tru-ponn-corp i am now out $700 intell i get my refund from paypal which may never come this is all one person i am not sure of their real name they claimed to be a drop shipper of ps3's Xboxes and other electronics but really he or she is just a scammer i had this person send out 3 Xboxes for 349.99 at the start then 349.99 when i had the tracking numbers and then i was supposed to send 349.99 on delivery but they sent out phone books and phone cables lucky this was all on pay pal but they told paypal that i told them to ship the phone books for 349 lol Here is the pay pal info Fom Seller: Laptops and such on 5/15/2007 09:31 PDT 791298899109,791298890112 here are the two track numbers of the packages i sent. I recive a email from stating that he/she had to deliver 3 packages to three clients in the usa. he/she also atated that it would cost him/her to much in customs fees to dleivery with profit and that where i came in she told me if i send them the packages that he or she would pay me 350 each package for my troubles. i sent two of the package becuase he or she only payed for two i assumed the last one would come shortly and this came up and here we are now. From Buyer: on 5/15/2007 09:06 PDT hello i sent this guy 2 payments of 349.99 he was supposed to send out Xbox elites but he sent out phone books and stuff he took my money his other a account is under firstname.lastname@example.com under the name Cynthia onet please stop this guy From Buyer: on 5/16/2007 16:29 PDT the seller statement is a complete lie he contacted me telling me he was a drop shipper he agreed to sell and drop ship 3 Xbox 360's elite for me i had them shipped to 3 friends in the us to test him he sent them phone books and cords his story doesn't even make sense how did he get the packages if i didn't send them to him from Canada? Then why wouldn't have i just sent them to my friends or if they were customers why would i care if they pay customs and why would he send a payment request for 3 Xbox 360's if he just send random packages that appeared out of thin air this guy is obviously not very smart if he's trying to scam people on pay pal i have tons of proof to back up my story just email me pay pal people if you need any more proof please get my money back i don't have time to waste on these scammers please help with my 2 transactions with this scammer thank you so this guy told me his name was mark ponn he was using this email@example.com email he then sent me a payment request from firstname.lastname@example.com which is registered to Cynthia onet he then had me send the payment to email@example.com claiming it was his business pay pal i was very suspicious but i really needed the Xboxes shipped the refund is still pending with pay pal sense then he has sent packages all over the place trying to trick pay pal with tracking info i really hope i get me refund but with paypal u never know whos side they will take West Vancouver, British Columbia
This report was posted on Ripoff Report on 05/23/2007 08:04 PM and is a permanent record located here: http://www.ripoffreport.com/reports/nathanial-ponn-david-ponn-mark-ponn-cynthia-onet-laptops-and-such-sititea-tru-ponn-corp/roxbury-massachusetts-02120/nathanial-ponn-cynthia-onet-mark-ponn-sititea-tru-ponn-corp-david-ponn-ripoff-laptop-250007. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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I stared at the path. I blinked, regaining my presence and glanced backward to make sure that Beau or Luke hadn't followed me. There was no one there. I knew that walking down the dirt path would cause more memories so I continued down the correct path.
There it was. My house, right in front of me waiting for someone to enter it, although, the door was ajar and I realised that mum probably hadn't left the house since I left, although that wasn't unusual for her.
I walked up the path slowly. I pushed the door fully open to reveal a dark and dusty house. The usually red carpet in the lounge room was a dusty, stained brown colour and there was a stench of alcohol in the air. I sighed. I knew what this was.
When our father died, mum lapsed into a silent place where she drank all the time, expecting me and Ali to supply her alcohol and she slept all day. I don't know what happened, but one day, a grandma of ours who lived in Connecticut flew over and stayed with her for the day.
After that, mum got a new job and changed completely. But she always stayed home. The only times she had gone out was to the gym, to Ali's funeral and to get certain items from Coles and Woolworths. Now, it looked like she had relapsed into that place.
If only she knew what it was like for me.
"Mum?" I called. There was a groan from the kitchen. I was prepared for most things, already having called my sisters name and then finding her dead.
"Ali? Dear me I must be really drunk, usually you only come into my dreams and remind me of happier times." She hummed a few bars of the Lion King theme song and I sighed. I looked at her and brought a tea towel down to her mouth. She grabbed it and wiped her mouth. Then she pulled me down to her for a hug. "Ali, I miss you so much."
She opened her eyes and then looked into my eyes with a certain spark in hers. The spark dulled when she saw my blue eyes.
"Oh, it's you." She said harshly. It was like she took a brand from the fireplace (if we had one) and shoved it into my heart. I felt the metaphorical fire die as she stood up and embraced me again. I didn't embrace her back. "You want shelter? Go to a homeless shelter." She slurred. I gaped at her.
"Why would you say something like that?" I asked her. She looked down at me and put a hand through her hair.
"I'm selling the house. I'm going to Connecticut to live with your grandma. You can either come or stay with one of those ugly little friends you always talk to. Little Ali loved it in Connecticut." She crooned, stroking a little heart necklace that she had on. She opened the heart necklace and I saw a picture of a little Ali. I frowned and bit my lip, wondering why she didn't have one of me.
"But….." I argued without any real argument behind me.
"Don't complain- it's not like you even remembered your Daddy. Shut up, get your stuff out or help me pack." She snarled. I was taken aback and I stepped back from her.
"I came to apologise, but sure. I'll get my stuff and go." I muttered. She smiled sickly at me and I ran up the stairs one at a time.
I could never get the hang of going up stairs two at a time. Ali could, but I couldn't.
I fished around upstairs for a suitcase or two, but I could only find a spare one of Ali's. It seemed like I had nothing anymore and the only stuff left was Ali's. It made me remember of all the times that we shared.
I looked at Ali's clothes, all folded up and nice, turned to mine and shoved most of them in the suitcase.
I looked up at Ali's bed and blinked the tears away. I couldn't believe that I was actually leaving for good this time.
I sat down on my bed which was still really neat and folded myself up on the bed to pull myself into my last memory. I said a silent sorry to Ali for immersing myself into this memory. I was quite certain that she would be in this memory. If I could have something that triggered this memory, I would have been in it all the time. I wish I could have seen this memory more. But sometimes, the happiest memories were the hardest to come by.
I closed my eyes and let my mind wander into the memory.


text: Visited here for a overnight stay.Because of vacation season only families were allowed. In the rest season only gents are also allowed and allowed to drink booze and all. Rooms were very poorly maintained..A/c and Television was not working properly due to voltage problem.Food was very poorly cooked .Beware of drinking the resorts water , carry your drinking water from... More


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Welcome everyone back to my blog. The NBA season is fast approaching, and I'm excited about that. The experiences that I've had this summer have pushed me even more to continue to play.
Right now, I'm just in it. I love the game no matter what. It's not about the money for me because I've made enough money in my career where I can walk away if I wanted to. I just want to continue to play and end my basketball career the way I want to end it.
The opportunity is there. A couple of teams have asked about me and told my agent they were pleased with the way I played in summer league. So for that to even be said from a team, with no negatives, means things are looking up.
While I was in Las Vegas for summer league, we had a couple of meetings and listened to a couple of speakers. One in particular stuck out to me because he said when his NBA career ended when he was 34, the phones weren't ringing. Nobody was calling him to put him on a summer league team or anything like that.
That put a lot in perspective for me, knowing that I still have a team like New Orleans that called and gave me a spot on their summer league team, as well as other teams who have checked up on me through my agent.
I just have to continue to work to earn an opportunity. I have places at home in Winston Salem and in Dallas where I can get a good run in. But I'm also going to get back out to Vegas to continue to go to Impact and work out. Hopefully, one of these teams will let me come work out with some of their vets like in August, early September, which I know that won't be a problem as long as I can get out there, and continue to focus.
I hadn't played in summer league since 2004, and I kind of forgot what it was like. But it was pretty cool to have that experience again, and I made the most of it by having fun and enjoying the game.
I want to say thanks again to New Orleans Pelicans for giving me that opportunity.
We started with a short summer league training camp in New Orleans, and I went in there ready to compete. I prepared myself to come into a summer league training camp in shape, so I wasn't lagging behind anybody.
I went out there and played hard, busted my tail, led by example, and let the young guys know that a 34-year-old vet can still do it.
That focus allowed me to earn a starting spot on the team, and once we got to Las Vegas, I did what they wanted me to do in the games that I played, which was for me to get out there, play and produce. I think I showed the Pelicans, along with other NBA teams, that I can still play. That's what they wanted to see.
The first game was pretty cool because we played the D-League Select Team, which featured some guys I played with and against last year in Austin.
Tre Kelley, who was our starting point guard in Austin before he got traded, was on that team. Devin Ebanks was on their team. My young fella, Terrel Harris, was on their team as well, but he was injured. So to see those guys who I've made relationships with in the D-League out there was cool. To have them out there still pushing made it even more fun and exciting in that game. It was good competition.
I ended up with 14 points in 20 minutes and that was fun. That's what I wanted to do with New Orleans through summer league training camp and all those practices. I wanted to go out there and have fun. That's what I had to take myself back to. It's about having fun, and doing something you love.
After that first game, I knew I wasn't going to get to play that much because the Pelicans wanted to get a look at the young guys as well.
The second game, our two other wing guys, Courtney Fells and DeQuan Jones, had great games, so there was no need for me to play. The third game that I got to play in was against the Spurs, and I think by then, the Pelicans already decided they had seen what they wanted to see from me.
The summer league is a different kind of NBA atmosphere, because the main purpose is getting those young guys geared up for the league. But it's also really good competition. It kind of takes you back to the NCAA tournament. Guys have to get ready from one day to the next. You might have an off day in between, but for the most part, it's pretty much back-to-back, so the mental aspect plays a big part in that tournament format.
I think Sacramento won, and I know they had a lot of second-year players on their team, which is pretty good for them as far as getting those guys ready for this upcoming season.
It's a very important part of the development of a young NBA player to get that experience. If the young fellas don't develop, it's tough for the vets as they get older and things of that nature.
I remember back in 2004, Marquis Daniels and I took our curves early on, but after that we took the opportunity and ran with it. When the opportunity presents itself to lead a team and grow as a player, you have to take it seriously. I think that's what helped Marquis and I have long careers in the NBA.
Outside of the games we played, I hung around the gym and watched a couple of games and got a chance to see some great young players from around the league.
I was impressed with the point guard that came from UCLA that's with Minnesota, Zach LaVine. I didn't really get a chance to see him that much in college since UCLA is based on the West Coast, so I didn't know much about him. But the way he handled the ball, the way he shot the jump shot coming off the dribble, he kind of reminded me of Deron Williams. I wasn't expecting to see a Deron Williams in the league anytime soon. But that kid right there I think is going to have a great NBA career.
Andrew Wiggins also showed some flashes of greatness. Ultimately, it's up to him to be as good as he wants to be, but to see the type of things he was out there doing already was pretty cool. I know he's probably worried about getting traded due to the Cleveland situation, but if there's any advice I can give him, it's just don't worry about it. That's a part of the NBA. You are the number one pick. Where you play from there doesn't matter.
The Pelicans have a great base of talent, and they also have a great coaching staff. Monty Williams has done a great job with those guys. Bryan Gates, Freddy Vinson and those guys took me in and let me play. They also let me play a veteran's role, talking to some of the players and stuff of that nature.
As a vet playing in the summer league, I recognized that some of the younger guys coming in didn't know what to expect and saw that kind of "deer in headlights" look, where they're just overwhelmed with the opportunity to play in the NBA. When I saw that in some guys, I just tried to mentor them a little bit and get them to remain confident in their game. I try to let the ones who will take it in know the right roles to take in the NBA, and just to be mindful of what's going on around them. It was great to speak with some of those young guys because I've been in their position before.
I also got to spend time with Anthony Davis, and talk to him about some things. He's a very humble young man, and he understands his surroundings. He's just focused on the game of basketball. That's good to have a young fella like that at the base of your organization that you can build upon and around.
As a player, Davis is really impressive. For his height, he kind of plays like a three-man. He's capable of handling the ball, he can post, and he can also knock down the face-up jump shot. So to have all those weapons and to be almost seven feet is great upside. I hope to see him go a long way, and just lead with those skill sets. It could happen.
New Orleans has a winner in him, a future all-star, and hopefully, a Hall of Famer one day. He might produce a championship or two for the Pelicans.
I also talked a lot with Russ Smith from Louisville, who was our point guard, and Pat Young from Florida, who was our power forward. I just tried to keep them motivated and confident even when they made mistakes like turning over the ball or not making the right play. It's tough coming from college to the NBA. I wanted them to stay focused. Overall, they did a great job. I was proud of them. Those two guys have tremendous upside.
When I wasn't playing, I tried to be as vocal as possible and help the guys learn.
I spent time talking to some of the guys coming in off timeouts, keeping them motivated. Summer league can be a drag as far as the length you'll be away from your family and those young guys are not really used to that. So keeping those guys motivated was my number one thing. Trying to keep a smile on their face I think is important, because if you're happy, you're going to go out there and perform.
I'm kind of a jokester so I had a good time keeping those guys laughing. I also had one of my teammates from the Toros, Courtney Fells, on the team, so he and I kind of teamed up and just led by example and tried to carry the young guys along.
I think highly of a lot of those guys. Many of them came from great programs. Even Jeff Withey, who is a second-year player from Kansas — he showed me flashes, things I knew he could do. But just to play alongside him, to see him develop from one year to the next, is a great thing to see.
After summer league ended, I was splitting time between Dallas and my hometown in North Carolina, where I held my camp from July 28th through August 1st.
This was the first year that I held the camp at two different sites, Hanes Hosiery and what was formerly Reynolds Park, now known as William Roscoe Anderson Recreation Center.
I noticed the last two years that some kids couldn't make it some days and other days they could. I knew a lot of those kids were from the side of town that I grew up on.
Even though it's a free camp, I got a lot of feedback from parents who were having a hard time getting kids from one side of town to the other, and it wasn't a problem for me to split time, go from one center in the morning and then go to the other center in the afternoon.
So we decided to split it up. To add some fun to it, we added a rivalry Friday when we hosted a championship with the two camps coming together for a showdown in the big finale. I think it added some excitement. I was hyping up both sides, and the kids were actually looking forward to that. It's cool to see talent from each side of town go head-to-head.
I think the kids also like the split camp even more because it gives them more space at each gym to do more drills and things of that nature, to hone in on their skill set instead of worrying about lines and stuff like that. It was a plus for both.
So it made a lot of sense to do it that way and the turnout reflected that. It was even better than we had in the past, which is amazing. To still have the draw that I get for a free camp here like I do in Dallas speaks volumes as far as what people think about me, and how I give back to community.
I honestly and genuinely care about these kids and what they do, and their future. If it wasn't for basketball with me, there's no telling what would have happened. But to stay focused and use basketball and the things I learned from basketball in every day life has really, really helped me a lot. And if I can get that message across to kids, I think they'll go a long way with or without sports.


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... but certainly not least, if you circle enough times you will eventually find what you are looking for.
Time for lunch. How about Cracker Barrel? Oops, looks like we did not beat the Baptist as there is quite a wait. What's our next choice? Let's see what we find. We are circling a shopping center and it offers lots of options. Nope let's go back to Steak n Shake. Sounds good to me. While we ...
Game Day
... but we got our dozen hot glazed doughnuts, and started eating. We even got to watch them being made. Time to see if we still fit in the car. We arrived back at the hotel, and Charles decided it would be in our best interest to take the remaining donuts to the desk crew at the hotel. Good call. She was excited to get them and was taking them home to her kids. We are headed home tomorrow but it has been a fun trip, in spite of the rain. Till ...
A Day in Rainy Durham
... fun place called The Blue Note Grill. On the way in we passed a train trestle that went absolutely nowhere. Blue Note is a barbecue place with live music. We did not have a reservation so we could not sit in the room with the music but we could go in to listen if we wanted to. Our dinner was BBQ sandwiches, salad and ribs. The BBQ was really spicy but good. My salad was big enough to feed a family of 4, but it too was good. After dinner we went to ...
In and around Durham
... up with some of his friends. Sunday saw us at the Washington Duke Golf Club and Inn for brunch - such a beautiful environment to enjoy brunch out on the deck. After such a lovely brunch there was time for Peter and Cam to chainsaw and pack some wood ready for the fire pit as September 1 heralds the first day of fall and the cooler days ahead. The leaves are beginning to fall and as the house is in a forested area there are plenty of leaves and it is a daily task to sweep ...
To the warmth of North Carolina
... by Cam using the remote control and watched on the relayed video on the attached I-pad. The video is so clear it is amazing. We soon attracted the few people who passed as they were keen to watch the drone and see the video. I can see lots of adventures with that toy and can think of others who would like one too. In the early evening we headed off to the American Tobacco Historic District - this area was originally the Lucky Strike Tobacco factory ...


text: Kaspersky Lab, in collaboration with international organisations, law enforcement agencies and Computer Emergency Response Teams (CERTs) is continuing its investigation of Rocra by providing technical expertise and resources for remediation and mitigation procedures.Kaspersky Lab would like to express their thanks to: US-CERT, the Romanian CERT and the Belarusian CERT for their assistance with the investigation. The Rocra malware is successfully detected, blocked and remediated by Kaspersky Lab's products, classified as Backdoor.Win32.Sputnik. Read the full research report of Rocra by Kaspersky Lab's experts please visit Securelist. Kaspersky Lab Newsroom Kaspersky Lab has launched a new online newsroom, Kaspersky Lab Newsroom Europe ( http://newsroom.kaspersky.eu/en), for journalists throughout Europe. The newsroom is specifically designed to serve many of the media's most common requests, making it easier for journalists to find product and corporate information, facts and figures, editorial copy, images, videos and audio files, as well as details about the appropriate PR contacts. About Kaspersky Lab Kaspersky Lab is the world's largest privately held vendor of endpoint protection solutions. The company is ranked among the world's top four vendors of security solutions for endpoint users*. Throughout its 15-year history Kaspersky Lab has remained an innovator in IT security and provides effective digital security solutions for consumers, SMBs and Enterprises. The company currently operates in almost 200 countries across the globe, providing protection for over 300 million users worldwide. Learn more at http://www.kaspersky.co.uk. For the latest on antivirus, anti-spyware, anti-spam and other IT security issues and trends, visit: http://www.securelist.com/. * The company was rated fourth in the IDC rating Worldwide Endpoint Security Revenue by Vendor, 2010. The rating was published in the IDC report Worldwide IT Security Products 2011-2015 Forecast and 2010 Vendor Shares - December 2011. The report ranked software vendors according to earnings from sales of endpoint security solutions in 2010. © 2013 Kaspersky Lab. The information contained herein is subject to change without notice. The only warranties for Kaspersky Lab products and services are set forth in the express warranty statements accompanying such products and services. Nothing herein should be construed as constituting an additional warranty. Kaspersky Lab shall not be liable for technical or editorial errors or omissions contained herein. Follow us on Twitter


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Recent publications
Reference: Östermalm's temporary market hallArticle: Carbon storagePlan B competition: Explore all designs
Completing the courses is easy: just register for the Timber Academy service, sign in and study.
The material covers all main product families and the courses have an interactive element – you study a product range and then answer questions.
One of the most important ways to mitigate climate change is to find new ways of capturing carbon from the atmosphere. As the building sector contributes up to 30% of global annual greenhouse gas emissions, it plays a vital role in battling climate change. Wood construction is a part of the solution, as timber products lock approximately 1 ton of CO2 per 1 m3 of wood."We need to search for the big picture solutions of today's vast climate, environmental and world housing needs. This requires looking at the fundamentals of the way we build – from the material choices of large urban buildings to the details of energy performance", Dr. Frank Werner from Frank Werner Environment & Development says.
The Hurlingham project in London involved the construction of a sports complex including four indoor tennis courts and four squash courts. The racquet hall, designed by David Morley Architects, is 35 metres wide and 55 metres long. The main span consists of suspended steel beams. To give the courts space and reduce the costs, the beams are spaced with large gaps of 12.9 metres. To fill these gaps, the architect wanted to see wood.
Architect Fabienne Bulle has been working enthusiastically with wood since her time in architecture school. Now she wants to share the story of how she "discovered" Kerto® LVL.
Watch video
Leading professionals who share our passion for engineered wood, specifically Kerto® LVL (laminated veneer lumber), have their say in the Talking Wood videos. Each expert talks about a subject close to the speakers' heart. If you'd like to share your story, please contact us.
As the climate is cold, trees grow slowly and this is why the wood fibres become dense, making the wood particularly strong but light, and visually consistent.
The wood we use at Metsä Wood comes from sustainably managed Nordic forests.
Benefits of sustainable Nordic wood
Nordic wood is sustainable
Metsä Wood's Kerto® LVL is a laminated veneer lumber product used in all types of construction projects, from new buildings to renovation and repair. Kerto is incredibly strong and dimensionally stable. Kerto delivers its high strength from the homogeneous bonded structure.
In an increasingly responsible world, wood gains in importance every day. Metsä Wood wants to play a crucial part in the development and growth of this global market.
Metsä Wood


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Animal Cracker Mailbag Express
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I'm Cameron Callahan, an indie comic creator from Southern California. I started making comics in January of 2009 after having lost my job. Since, I've released a handful of print comics, contributed comics to anthologies and magazines, and have had my comics reviewed on The Comics Journal website. The Animal Cracker Mailbag Express aims to provide updates once or twice a month on new projects by me and friends - Mostly comic book related but sometimes we like to dabble in other storytelling mediums.
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Hotel Margherita
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- Beach
- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
- Beverage Selection
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Day 3
We began our third day in Italia by waking up early and catching the vaporeto to which would take us to the train station at St Luchia stop in Venezia, we would then catch a train to Milan. When waiting for our vaporeto we were a little concerned as we thought we missed it as the time was extremely past its predicted arrival time. As we worried a little some people next to us informed us that the vaporeto service starts at a certain time each morning resulting in the early boats not ...
... of canals and therefore a city of hundreds of bridges, all with lots of steps. Don't waste time and energy and money getting to another part of the city with your luggage. A water taxi costs upwards of $75 US. Vaporettos, or water buses cost $7 each trip. We read and saw YouTube vids of miserable tourists lugging too much **** up and down lots of bridges. Walking through this city is part of the charm, but only if you are ...
No Map Required
... at her to get off, which she did. I tell you we have seen some extremely rude people who really just don't have any consideration of others. It is the survival of the fittest and every man or woman for themselves.
We wandered up and down the market stalls and saw all the same rubbish that we'd seen in other cities. However, for all you fashionistas, the stores have started displaying the winter styles. If anyone wants to know, it's fur, fur and more ...
Piazza San Marco & Water Taxi Adventure
... the Grand Canal at San Marco and proceeded to window shop some more in preparation for our, or I mean my, much anticipated ghost walk of Venice. The tour began under rainy skies as we ventured to the deep, back alleys of Venice. I always find it interesting the people who are in ghost tours. They're probably the people you would expect but with a number of normal people like us...wait, are we normal? The tour consisted of gripping tales ...
... that she had some distant friends to catch up with.
she gave an invitation for me to come, I declined because I wanted to see if my old mate would give me the recipe for his home brewed beer.
We both parted our own ways and I managed to get the recipe for the home brew beer. It didn't take all that long to get.
Then I just strolled home and had a rest until I went had got some take out pasta for dinner.


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Motel 6 Grand Rapids North Walker
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Fish and Chips, Haggis, and Black-pudding...Oh My!
... further, the pound is just too expensive. The meal from start to finish was excellent including the wine, you have to do this at least once on vacation:-) Honestly I enjoyed the food and we never had a bad meal, they have perfected even the hearty meals with excellent ingredients and flavors. The experience you have in regards to meals is completely up to you. I don't usually take this many photos of my food but I think this is a good documentation of our ...
The long drive for a short distance
Ty and I got home after baseball at 1 am Tucson time.. Isaac is soon getting up and headed over to load 20 min away at 5 am Michigan time.. But there is a catch; gps on his end goes down, truck won't move in drive, no coffee, no food; dads not a happy camper...it is now apparent that mom shouldn't be either.. Lol,. From ...
Rain jacket...check...or should I say Mac check...
... we are there so that we can pack lighter. I say lighter because we are still American come on now! Honestly it is pretty easy to find a laundry (launderette) in most towns and for a little higher rate they will wash, dry, fold and deliver your clothes back to your hotel/B&B in one day. Something to think about before you pack all that stuff you will never wear:-)
http://septicscompanion.com/showcat.php ?cat=clothing
Hi Lo
... our hotel room at the residence inn LO- daddy almost not letting us eat at Philip's diner Ben: HI- Swimming in the pool at the residence inn LO- Tommy: HI- swimming LO- none Walnut Grove: Scott: HI- getting home LO- the alarm in the middle of the night Melissa: HI- getting home LO- getting up so early Edie: HI- Seeing Oscar LO- wanting to get home so badly Ben: HI- Seeing Oscar LO-it taking so long to get home Tommy: HI- getting treats from Burger King ...
... to learn from this experience for the rest of my life. It's difficult for me to sum up what I learned right now because I know I will only continue to learn from it. My hope is that I will be less stressed out by day-to-day life and that I will try to enjoy it to the fullest. At the end of placement, I was teaching at a school with normal teenagers and having normal relationships with them. Although I ...


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Super 8 Pekin/Peoria Area
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First Night Out
Now that I have no where to be there is no reason to make 500 miles a day. We decided to pull off about half way to Iowa. Having driven in rain for an hour it looks like it is coming back. We have stayed in this park some 20 years ago, but it looks like there are many improvements. As we pull into our site it starts to rain. It is always fun setting up in the rain. As the day turns to night the rain gets heavy and I am thankful we ...
Day 39 Just when you thought it was safe!
... the bike on his trailer and drop it at his workshop and he would check it out tomorrow morning (Sunday). So Ron bundled me into his truck with Lucky, his lovely old cross border collie, and off we went to get the trailer.
To get the bike up the trailer's ramp when we got back to the bike, Ron said we needed at least 3 people - no problem - before we knew we had about 5 locals pitching in the get the bike secured. ...
Cultural Opp. 1- Concert
... br> Don't stop believing
Hold on to that feeling
Streetlight people
Margaretville- The man JIMMY BUFFET
Nibblin on sponge cake
Watchin the sun bake
All of those tourists covered with oil
Strummin my six-string
On my front porch swing
Smell those shrimp they're beginnin to boil
Wastin away again in margaritaville
Searching for my lost shaker of salt
Some people claim ...
My Unexpected education
... mystifying but unfortunately he was unable to delve into his audiences imaginations and make them want to believe that what they saw happening before their eyes was real, even though it actually was, they still disbelieved. For you see, or maybe you don't, Michael at that point was unable to comprehend most emotions that we feel and deal with daily. Love, faith, laughter these were alien ...
Old Magic by Marianne Curly
... standing at the head of the class, looking as awkward as any new kid would look. Several of the girls in the class were eyeing him as if they found a new favorite flavor of Ice Cream. That probably came with being in such a small town. I would be eye balling any new guy walking into class, too, if I was held up in a small town on the top of a mountain all my life with the same faces to stare at day after day… ...


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The immigration department has attempted to cover up alarming rates of children's mental health problems in detention, an Australian human rights commission inquiry has heard.
Former and current detention centre workers gave evidence to the inquiry into children in detention that conditions were substandard, unsafe and inappropriate.
Doctors who worked on Christmas Island recounted shocking details of medical neglect, including stripping asylum seekers of basic medication when they arrived, as documented in a letter of concern written by 15 doctors working on Christmas Island and reported by Guardian Australia.
Former workers in detention centres on Nauru also gave harrowing accounts of the conditions for children, including the case of sexual assault on a teenage boy, first reported by Guardian Australia in June.
A former departmental official described the purpose of immigration detention as "to remove hope" for asylum seekers.
The inquiry heard that the immigration minister, Scott Morrison, has agreed to appear before the panel, making the prospect of another public hearing likely.
Mental health statistics covered up, says senior doctor in immigration detention:
Dr Peter Young, the former medical director for mental health for IHMS – the private healthcare provider in immigration detention – was compelled to attend the hearing in Sydney, where he said data presented to the department within the past two weeks had received a "negative" response and that the department "asked us to withdraw the figures from our report".
His evidence drew gasps from the gallery as a projected image of the statistics showed that 15% of children in detention on the mainland and on Christmas Island were scored three-four on the HoNOSCA (Health of the Nation Outcome Scales for Child and Adolescent mental health) for symptoms of emotional distress – Young said a score of two was "clinically significant".
Young said statistics compiled by IHMS showed a third of people held in detention had mental health problems, and it was "clearly established" that such problems were caused by prolonged time in detention.
The inquiry has published statistics showing that between January 2013 and March 2014 there were 128 incidents of self-harm involving children in Australia, constituting of 62% actual self-harm within the detention centres where children are held.
Young told the commission he was aware of self-harm incidents involving asylum seeker children, including poison attempts. He told the inquiry that there was no full-time child psychiatrist on Christmas Island or on Nauru, but that staff rotated the role.
Later three representatives from the Department of Immigration and Border Protection – department secretary Martin Bowles, deputy secretary Mark Cormack and assistant secretary Katie Constantinou – told the inquiry they were unaware of the request to withdraw the figures.
Bowles said if any department staff had acted "inappropriately" he would "deal with that".
The department conceded on a number of occasions that prolonged detention had adverse affects on asylum seekers' mental health. Asked about the rate of self-harm, Cormack said the department was "not contesting" research that found prolonged detention produced a "whole range" of effects.
Immigration department overriding officials and delays in treatment:
Young said the immigration department often overrode medical advice for the treatment of asylum seekers in detention, which he described as "troubling".
This experience was backed by two former Christmas Island doctors, John-Paul Sanggaran and Grant Ferguson, both of whom signed the Christmas Island letter of concern.
Sanggaran and Ferguson relayed a number of details documented in the letter, including issues with medical diagnosis on the island, shocking facilities and the inability to transfer patients needing urgent treatment.
An epileptic girl had her medication stripped on arrival at Christmas Island – as is standard practice – and doctors could provide only one of two necessary pieces of medication.
"She started having seizures," Ferguson said. "She was left on that one medication. We eventually got supply of that medication she arrived with, but they only ordered a month's worth, so in a few weeks' time they ran out and she was back to one [medication] again, and this whole time she was having seizures."
He said the girl was eventually transferred off the island after repeated requests by medical staff.
Sanggaran reiterated his criticism that IHMS had not adequately responded to criticisms articulated in the letter.
Ferguson described conditions on Christmas Island as a "disaster zone".
Elizabeth Elliot, a paediatrician who accompanied the human rights commision on a three-day visit to Christmas Island earlier in the month, said she observed children unable to get treatment for conditions including an undescended testicle, abscesses and skin problems.
She said many children were suffering serious mental health issues. One girl had withdrawn to her room, stopped eating and told Elliot "it would be better to be dead than living here".
"Almost every child we spoke to, that could articulate their feelings, expressed distress," Elliot said.
Elliot confirmed that unaccompanied minors had recently been transferred from Manus island – highlighting, as Guardian Australia revealed, that children were on Manus during the violent unrest that left one asylum seeker dead in February.
Elliot said 15 women had been placed on self-harm or suicide watch on Christmas Island and rejected claims by Tony Abbott that those who self harmed were attempting to hold the government over a "moral barrel".
"Take a step back – what woman would self-harm unless they were absolutely desperate?" Elliot said.
Bowles rejected claims about the conditions on Christmas Island and said the characterisation presented was "quite disturbing".
Asked how many children and infants were among the 157 Tamil asylum seekers now held at Curtin detention centre he said the department was still addressing the "biodata". The response drew derisive laughs from the gallery.
Bowles was asked if detention conditions were designed to "break people". Visibly frustrated, he said: "I'm actually quite offended by these statements." He suggested they prevented detention centre staff doing their jobs properly.
Shocking conditions for children on Nauru:
Kirsty Diallo, a former social worker employed by Save the Children on Nauru, recounted numerous examples of the poor state of care for children.
She told the inquiry children had begged her for shoes with no holes in, for books and for clean clothes. Diallo said one mother had become so desperate for clothes for her daughter that she stitched a dress from a mosquito net for her.
Diallo also documented cases of abuse, including the sexual assault of a teenage boy by a detention centre cleaner on Nauru. She said she had observed teenage asylum seeker girls in the centre engaging in "flirtatious behaviour with adult guards", of guards stroking girls' hair and of guards holding a three-year-old on their lap. She said an asylum seeker child had been threatened by a detention centre staff member with a cricket bat.
"You can't do trauma recovery work when children remain unsafe," Diallo said. Nauru was "completely inappropriate for children".
Ai-Lene Chan, a doctor who practised on Nauru, said she encountered shortages of anti-depressants and antibiotics, meaning asylum seekers' medications were often "abruptly stopped".
She spoke of one child, a teenage boy who had a "complete loss of hope".
"He had no appetite or will to live. He lost over 10kg of weight, about a quarter of his body weight," Chan said.
Chan said the doctor employed in the Royal Nauru Hospital as an antenatal specialist did not hold the correct qualification and was trained in PNG. He eventually lost his job.
"I believe that Nauru is absolutely not a safe environment for children to be detained. I believe the detention environment creates the overwhelming majority of physical and psychological ailments," Chan said.
She knew of unaccompanied minors and teenagers on Nauru who had been placed on suicide and self-harm watch.
A former immigration department official, Greg Lake, who worked as the centre manager on Nauru until the middle of 2013, said the purpose of detention, as he understood it, was to "construct an environment where people are used as examples … to remove hope".
Lake, who also served as the director of offshore processing and transfers when the centres on Manus and Nauru were reopened by Julia Gillard in 2012, said he was instructed by the government to pick "children who looked the youngest" to be on the first flight to Manus. This, Lake said, reflected the government's desire to send a strong message to people smugglers.
Outside the hearing:
At a break in proceedings, the human rights commission president, Gillian Triggs, said: "The inhumanity, the cruelty of these processes is very apparent and when it's repeated without any conditions attached by all of these medical experts, as Australians we have to ask: have we gone too far?
"The minister [Morrison] has a responsibility to be much more transparent about what is happening.
"We're trying to get facts right when frankly it would be much simpler for the minister to provide the Australian public with this information in the first instance."
Abbott told reporters in Hobart no one wanted children to be held in detention, but the best thing the government could do was stop the people-smuggling business.
"What could be more horrific than the idea of children perishing at sea because their parents have fallen for the false promises of the people smugglers?" the prime minister said.


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QuestionClick here to send us a question
I want my baby girl to be named Inaya, while surfing net I found alternate spellings and meanings of name Inaya, Inayah etc.
Inaaya - meaning Gift of Allah, however I couldn't find any Quranic orgin of this meaning.
Complete name of my baby will be Inaya Aamir, please inform us that combination of twos names will appropriate and well suited to my baby girl and correct spelling to be used for the name.
This is an official answer by QuranicNames.com Staff
Inaya, which can also be spelled as Inaaya and Inayah, is an Arabic name that means "help", "care". Some people interpret this to mean "help that comes from Allah", which can also be considered to mean "gift from Allah".
You can read more about this name here:
Inaya Aamir is an acceptable name and the spellings are acceptable. There is no official spelling for Arabic names, you can choose any spelling you like. You can write her name as Inayah Amir, Enayah Aamer, or any other spelling you prefer.


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International Centre for Mathematics and Computer Science in Toulouse
March-July 2017
Invariants in Low Dimensional Geometry and Topology Semester
Low-dimensional topology and geometry are inextricably linked and faced an impressive growth in the last thirty years.
March-July 2017
Decision Making Semester
Researches around Decision Making can be seen in two categories.
12-15 June 2017


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Testing iOS app HelloMind
This project was awarded to sanaakhlaq for $11 USD / hour.Get free quotes for a project like this
Project Budget$11 USD / hour
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We need you to test our app HelloMind. It is a test of the whole app with a detailed testrail. The app is a mental health app, that uses hypnosis to break bad patterns in the users life. We have released the app but feel like we could use a good solid testing of it anyways. check it out on [url removed, login to view]
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Posted March 23, 2011 by Global Vito in Media
Living Proof with Sway Part 2
Part .2 of ALMG with Sway, they discuss some of his most notable interviews of the past 10 years. Specifically, with an emerging 50 Cent, who was on the come up. ALMG also talked about Sway's interview with HEavy Hitters own Kanye West, which happened right after the Roc-A-Fella break up. Finally, his interview with Solar after the death of Guru. Big Thanks to ALMG & Sway for Sharing this on Thatsenuff.com.


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Genetic epidemiology and genetic associations
Mutations in the cyclin-dependent kinase-like 5 gene (
We performed mutation screening of
Six previously unidentified DNA changes were detected, two of which were disease-causing mutations in the catalytic domain: a frameshift mutation (c.509_510insGT; p.Glu170GlyfsX36) and a complete deletion of exon 10. Both were found in patients with seizures that started in the first month of life.
This study demonstrated the importance of
Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of spoken language and hand use, hand stereotypes, and mental retardation
The cyclin-dependent kinase-like 5 gene (
The clinical overlap between patients with mutations in
Patients were referred to our diagnostic laboratory for investigation of
These patients were referred by various paediatric neurologists and clinical geneticists throughout Spain, and were included in the present study after signed informed consent forms were obtained from the patients' parents.
One hundred DNA samples from anonymous healthy female individuals were used as normal controls for exons 1, 12, 17 and 21 (200 X chromosomes). The samples were obtained from the Basque Centre for Transfusions and Human Tissues. The samples and associated data were processed and released by the Basque Biobank for Research-OEHUN (
Screening for
Rearrangements studies
Genomic rearrangements were examined using multiplex ligation-dependent probe amplification (MLPA) kits (P189-A2 and P189-B1, MRC Holland, The Netherlands), according to the manufacturer's protocols.
RNA isolation and reverse-transcriptase PCR
We used cDNA to study mutations/variations in exons 8 and 12. Total RNA isolation and cDNA synthesis were performed as described previously
In both cases, the PCR products were directly sequenced on both strands using a BigDye Terminator Kit (Applied Biosystems) in a 3130xl automated sequencer (Applied Biosystems).
X chromosome inactivation
X-chromosome inactivation was studied by examination of the highly polymorphic small tandem repeat within the human androgen receptor gene, using previously described protocols
The pathogenic mutations, variants, and polymorphisms identified in the current study are listed in Table
The first of these two new mutations was a pathogenic frameshift mutation in exon 8 (c.509_510insGT; p.Glu170GlyfsX36) producing a truncating protein in the catalytic domain that contains only 206 amino-acids on the 1,030 that has CDKL5 protein. The patient was the first child of healthy parents. She was born in a private clinic, and we were unable to obtain all the details related to the delivery, but established that resuscitation had not been required and the infant's birth weight was 3,450 g. The infant started to have seizures at 4 weeks of life, with facial flushing, vomiting and crying. The family contacted us when the patient was 11 years old with a clinical diagnosis of RTT, with severe mental and psychomotor retardation, poor social contact, axial hypotonia, spastic tetraparesis and epilepsy refractory to numerous treatments.
The second new mutation was a complete deletion of exon 10 (p.745-?_825 + ?del) detected by MLPA (Figure
Figure 1
Complete deletion of exon 10 detected by MLPA (A) and confirmed by cDNA analysis (B).
Complete deletion of exon 10 detected by MLPA (A) and confirmed by cDNA analysis (B).
Four other new DNA variants were identified, including c.1455_1460delGGCCAA (loss of lysine and alanine amino acids) in exon 12. This patient was referred to us at 3 years 2 months old by a paediatric neurologist because of developmental delay, absence of speech, seizures, and difficulty in walking (possible ataxia), though her initial psychomotor development was normal. She was the second child of healthy parents, and had a healthy 13-year-old sister. She had her first febrile seizure at the age of 11 months, and her mother reported that her development "stopped" after this episode, including with respect to her speech (possible regression). We initially classified this DNA variant as non-pathogenic because her asymptomatic mother had the same variant, and both the mother and infant showed the same cDNA and random X chromosome inactivation. However, this variant was not present in the 10 genomic databases consulted, or in the 100 normal control samples, and we therefore reclassified it as an unknown variation.
The second DNA variant was c.2389 G > A (p. Asp797Asn) in exon 17. This was inherited from the father and was therefore not a pathogenic mutation. Six other females in the healthy control group also showed this change, indicating that it represents a newly-described polymorphism in Spain.
The remaining two novel DNA changes had no clinical significance: c.−426 C > G and c.403 + 27A > G. The first was also found in five healthy female controls, and thus represented another novel polymorphism for Spain.
Finally, we detected three previously reported variants. The variant c.2995 G > A (p.Val999Met), first described by Nectoux
This complete genetic study of
The two new mutations were found in girls with severe encephalopathy, autistic characteristics, severe deterioration of psychomotor development and onset of seizures within the first month of life, although there were some phenotypic differences between the two cases. These characteristics are in agreement with Bahi-Buisson
Recent studies have focused on better characterising the relationships between genotypes and phenotypes, given that phenotypic heterogeneity caused by mutations in
There is evidence that CDKL5 interacts with MeCP2 and modifies its phosphorylation. Castrén
X-chromosome inactivation is known to impact on the clinical manifestations of X-linked disorders; however, this point cannot be investigated in studies that use blood, rather than brain cells
Finally, this study highlights the importance of analysing rearrangements of the
The results of this study confirm that
Competing interests
The authors declare no conflict of interest.
Authors' contributions
MTC, RD, FR, AGR, MJM and MALA acquired and provided clinical data and samples from their patients. HM, CMB, NP and IR produced and analysed the molecular data. HM wrote the manuscript. MIT designed, supervised and directed the project and revised the manuscript. All authors read and approved the final manuscript.
This project was financially supported by Grants 2007111045 and 2011111090 from the Health Department of the Basque Country Government. We are indebted to the patients for their participation in this study and to the Basque Biobank for Research-OEHUN for providing normal control samples. We are also grateful to Ainara Revilla and Cristina Prieto for their help with the normal control population study.
Rett syndrome: revised diagnostic criteria and nomenclature
The story of Rett syndrome: from clinic to neurobiology
CDKL5, a protein associated with Rett Syndrome, regulates neuronal morphogenesis via Rac1 signaling
The three stages of epilepsy in patients with CDKL5 mutations
A novel mutation in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene associated with a severe Rett phenotype
CDKL5 belongs to the same molecular pathway of MECP2 and it is responsible for the early-onset seizure variant of Rett syndrome
Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes
Mutational spectrum of CDKL5 in early-onset encephalopathies: a study of a large collection of French patients and review of the literature
Identification of a novel CDKL5 exon and pathogenic mutations in patients with severe mental retardation, early-onset seizures and Rett-like features
CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms
Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation
Early onset seizure and Rett-like features associated with mutations in CDKL5
Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling
Xq28 duplications including MECP2 in five females: Expanding the phenotype to severe mental retardation
Maternal origin of a novel C-terminal truncation mutation in CDKL5 causing a severe atypical form of Rett syndrome
Mutation screening of the CDKL5 gene in cryptogenic infantile intractable epilepsy and review of clinical sensitivity
Mutations in the X-linked Cyclin-Dependent Kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation
Clinical phenotype of 5 females with a CDKL5 mutation
A girl with early-onset epileptic encephalopathy associated with microdeletion involving CDKL5
Key clinical features to identify girls with CDKL5 mutations
A novel p.Arg970X mutation in the last exon of the CDKL5 gene resulting in late-onset seizure disorder
Epilepsy caused by CDKL5 mutations
Genes of early-onset epileptic encephalopathies: from genotype to phenotype
Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic encephalopathy
Early-onset seizure variant of Rett syndrome: definition of the clinical diagnostic criteria
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Demrin crouched next to the bed Adder lay on. His injuries were severe, the marks and wounds where the shadows had hit him clearly evident on his pale skin. The vampire's eyes had rolled back into his head, and his breathing was coming in ragged gasps. Demrin checked his heartbeat; it was beating nearly two hundred times a minute.
"He is close to death, Calla, but I think I can save him".
"He better not fucking die, he better not" Calla said, taking the vampires hand as a tear formed in the corner of her eye.
Demrin reached into his cloak, delving into the many inside pockets and he withdrew a large glass vial, several herbs and four potions.
"I will need your help, Calla if this is to work".
"Yes, yes anything", she replied, dropping the vampire's hand and turning to Demrin who had opened one of the potions.
"Have him drink this, all of it now. It will start the healing process by slowing his heart almost to a stop and calming his breathing".
The succubus took the substance, an orange coloured one and poured it down Adder's throat. The difference was noticeable immediately; his chest falling regularly, his heartbeat almost non-existent. Demrin was readying s salve, crushing herbs and mixing them with another of the potions, a green one this time.
"Dab each of his wounds six times with that mixture, and they shall start to heal".
Calla did so, making sure to get every last wound on the vampire's body. Demrin held his hands over Adder's body and began uttering few words. He took his hands away after a moment.
"The shadows which attacked him cannot be healed with a normal spell, it's going to require me to use the shadows. I will have to pump new ones into him, while drawing the ones which are killing him out, channelling them through my body, and into this", he said, indicating the large, empty glass vial.
"No Demrin! You can't... That could kill you".
"It is a risk I am willing to take. Normally I would not go to these lengths for a vampire, especially one who had tried to kill me, but you and he have a special bond and I don't think you would ever forgive me if I let him die. You are the only friend I've got, Calla. Maybe that girl, Ana will become a friend, if she accepts my offer, but I damn well aren't going to let you suffer the loss of someone you have fallen in love with. I myself experienced it many years ago, and now, whenever I see her, the feelings are rekindled but I know I can do nothing. It is one of the worst pains anyone can experience, losing the one they love. You shall not experience it".
Demrin grasped the vial in his left hand, held his right hand over the vampire's chest and readied himself.
"When the vial is half full, feed him the purple potion, when it is completely full, the yellow one".
Then he formed a ball of shadow around his hand. He lowered it onto Adder's chest, and began forcing the shadows into the vampire's body. As he did so, he felt tightness in his chest. The shadows from Adder were travelling through him, attempting to kill him. There was every chance they would succeed, and then he and Adder would both die.
He gasped as a piercing pain racked his entire body. He began convulsing, as did Adder. A steady flow of shadow had sprouted from his left hand, entering the vial. The flow of shadows from his right was wavering, and through his pain, he forced more into the vampire, pushing himself to his limits. He glimpsed Calla pouring a purple substance down Adder's throat. They were only halfway, and it was beginning to get difficult to sustain the flows.
His flesh seemed to be burning, visions flashed across his eyes, horrifying visions to terrible to describe. Adder's body bucked, leaping a full two feet off the bed. Demrin's body mimicked the action soon after. His hand was locked to the vampire's chest. He could not move it a millimetre.
Shadows exploded in Demrin's mind and he screamed. An identical scream issued from Adder's now open mouth. Demrin again glimpsed Calla. She was pouring a yellow liquid down the vampire's throat. The shadows ceased to flow, and Demrin slumped next to the bed, exhausted. He could barely move. Someone arrived at his side, holding a large mug of vodka. They poured it down Demrin's throat and as the spirit burned its way through him, Demrin felt refreshed. He saw that it was Calla crouched next to him, tears flowing down her face.
"You did it, Demrin. He is fine, you are both fine". She hugged him. "I thought you were both going to die when you started bucking and screaming, but you did it".
"Yes, I guess I did", Demrin said still slightly groggy.
"Adder will be so grateful, you putting your life on the line for him like that".
"I did it for you" Demrin said, then collapsed in a heap. The last thing he saw before he fell completely unconscious was the arrival of two more people to the room, a girl and a man in a suit.


text: The drug marijuana is derived from the leaves, stems and other parts of the hemp plant Cannabis sativa, contains delta-9-tetrahydrocannabinol, or THC, a psychoactive chemical which affects areas of the brain associated with pleasure, memory, thinking and coordinated movement. Although Federal law prohibits marijuana possession, distribution or use, 18 states and the District of Columbia now permit marijuana use for medicinal purposes and Colorado and Washington permit recreational use of marijuana among adults.Quest Diagnostics is a leader in prescription and workplace drug monitoring by diagnostic testing. The company's Drug Testing Index™ is widely considered a benchmark in national trends of drug use by American workers. The company extended its drug monitoring services with the addition of a new portfolio of prescription drug monitoring services for clinicians in 2010. A separate press release issued last week by Quest Diagnostics provides additional information on the report's findings on overall prescription drug misuse rates. Study Strengths and LimitationsThe study's strengths are its size and national scope; use of an objective laboratory method, versus surveys or polls, which may be subject to user misrepresentation or error; confirmation of all positive drug screens by mass spectrometry, the most advanced drug testing method; and inclusion of patients under care by clinicians in a primary care or pain-management setting, but exclusion of those in drug rehabilitation or addiction treatment settings, where unusually high rates of drug misuse may be expected. Study limitations include geographic disparities; inability to confirm drug misuse through access to medical records or clinical evaluation; and technological factors and patient variations, such as drug metabolism and hydration state, that may affect the reliability of a minority of results. Quest Diagnostics does not provide services to all clinicians in the U.S., so results are not broadly representative of all patients taking prescription medications in the U.S. It is also possible some clinicians tested patients due to appropriate suspicions of drug misuse, and that some clinicians omitted to specify all drugs prescribed for the patient on a test order, skewing some results.


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Costume Photos
Costume Information
|Dave and I have always liked Animal Crossing and I'd been thinking for a while that Tom Nook might be a fun cosplay. We've been playing New Leaf and I decided to make the Tom Nook costume, along with a Redd one for Dave.
Just a simple costume to wear as a floor costume, along with some little props that were fun to make.


text: Boston Market : 50% Off Any Family Meal Purchase on 5/27 Coupon See Deal Flag this deal Edit deal What's the matter? Choose a reason Dead deal Duplicate Bad link Spam Inaccurate No value Alive again Comments (1) themoneyman1113 May 22, 2013 They do this every year on Memorial Day, I worked at Boston Chicken aka Boston Market as it is now called and Memorial Day weekend is one of the slowest 4 days ever, except for those rare rainy weekends. Reply Cancel Load More Comments


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Working at a company that builds websites we get this question all the time, "When should a business update or redesign it's website?" Well there are several factors one needs to consider such as: the number of visitors, where they are going when visiting and how long they staying; what kind of conversion rate is the site getting; what kind of functionality is your business getting from the site; is the site integrated with your other marketing activities; and, how does your site compare to competitors (aka, does your site look dated or ugly). During this webcast, we are going to cover the several major concepts that are related to ensuring a smooth redesign project. Some topics include: Technology considerations; Business Analysis and User Experience; Design Trends; Development and Architecture; and, Quality Assurance. Register - http://bit.ly/YZ51sz
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Arrest made in Maine 3-county burglary spree
WAYNE, Maine — Kennebec County sheriff's deputies say they are working with two people they think are connected to a string of burglaries in Kennebec, Franklin and Somerset counties.
Police think the suspects are responsible for at least 30 and maybe as many as 50 or more burglaries in the last three months that have netted "tens of thousands" of dollars in goods.
Justin Ross of Wayne was arrested last week on charges of burglary and theft.
|The article you requested is no longer available on BostonHerald.com.
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- Justin Ross


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I let out a laugh when I saw last week's Onion article, 8.4 Million New Yorkers Suddenly Realize New York City A Horrible Place to Live. It seemed especially silly to me, as I'd just finished Elizabeth Currid's, The Warhol Economy– a book that identifies the unique characteristics that have made NYC an international mecca of creative production. Despite the fact that the book raves about the benefits of NYC's unique environment for artists and the career development of creatives, the Onion article got me questioning the future of this city.
Some of the key social and economic qualities that have made New York City so successful as a place for creative and cultural career development have been (and, I would guess, will continue to be) replaced by online social networks. "Every generation has its own neighborhood," Zac Posen said of NYC to Currid during an interview mentioned in the book. I predict that for Generation Y, and perhaps increasingly for the generations following us, that neighborhood will not be Chelsea or the West Village. It will be online.
Here's how social media and online networks match up to the key elements that secured NYC's reputation as an international center for creative development:
1. Low economic barriers to entry in the community
Utilizing social media is catching on quick, and is a relatively cheap endeavour. The rise of New York City as an international hub of creativity also arose from low barriers to entry. Namely, the recession of the 1970s created cheap rents that allowed artists to focus more time and energy on their artwork instead of taking up second jobs to make ends meet. Artists bought up low-rent spaces in many of the same neighborhoods, resulting in communities of creatives with a little more time on their hands and getting a little more bang for their buck. All you needed then was a little bit of money (to afford rent), something to say, and the ability to relocate to New York. In order to enter an online community today, the barriers for entry are even lower. You don't need to move to New York. You just need a little bit of money (to afford a computer) and that same something to say.
2. Production with no real regard for economic growth
There are more than 900,000 blog posts put up on the Internet every 24 hours. Why do we blog? The answers may be shockingly similar to those of "why do we make art?" Some people blog for emotional release or to create a connectedness with the world. Some people blog to make money, but a lot more people (including myself), blog to create symbolic capital. In other words, to gain or maintain regard as a professional in the field you're writing about. (I utilize my human capital to discuss social capital on this blog to build my symbolic capital! Yes, these are the things your brain comes up with when you are in grad school…) In fact, according to Pew Internet and American Life Project, to make money is the least common reason why people blog. The main reason? Creative expression. Social media and online expression share the same emotional (and similar economic) fuel that drives NYC's creative community.
3. Utilizing and building weak ties
In her book on NYC's creative economy, Currid cites the work of Dr. Mark Granovetter who has published significant studies on the importance of "weak ties." He found that the ties that were farther away from us (versus our close-knit friends) were most influential in creating success. People with the most weak ties are in the greatest position to "diffuse innovation." While having social exchanges with random folks on the street in New York City does create weak ties, it's much less hard to imagine how social media promotes these kinds of relationships. Also, social media makes it easier to track weak ties. One needs only to check their @replies on Twitter to get a good sense of the weak ties they've created. Social media is a large network of these weak ties. And more than that, they are more easily tracked and weak ties can more easily grow stronger through social networks than meeting someone on the street in NYC- a method that has worked for generations before.
4. The ease of peer review and access to gatekeepers
Listen to the story of any great artist in NYC and they will tell you the stain of people that they met that helped them get to the top. In NYC, there are places where 'the cool kids' hang out. There are places to see and be seen. It's not a stretch to say that there are a hierarchy of sites upon which bloggers and social medialites aim to be mentioned or linked. My boyfriend's startup sees a greater rise in visitors when it's mentioned on Mashable than when it's mentioned on a random blog. The higher the site is on the totem pole, the more likely your work is to be seen by gatekeepers- key people in your industry with the power to aid you in achieving success. This is the same way it works in posh nightclubs, bars, and museum events in NYC. The reason online interactions may have the upper-hand? They are remote.
5. More creative people leads to economic productivity
You don't need to be in New York anymore to have access to the most influential gatekeepers, or to get attention for your cause or story. The game is changing. In New York City, the above factors created ideal conditions for the spread, sharing, and development of creatives. Similarly, on web, the above factors create ideal conditions for the spread and development of creatives– but also for non-creatives. In a sense, New York just got bigger. Now it's the entire world. Or rather, anyone with a computer or access to the library.
Social media networks have other advantages that NYC (or any physical location) lacks. This may change our idea of location as ideas are spread freely with no regard to physical region. For instance, time plays a different role. You don't have one chance to hand over your business card- as you might when running into an ideal client on the street that you may never see again. You can send a message (or respond to that message) at your leisure. This may lead to more strategic communications. Also, places with more people see more economic activity, and for that very fact, it is a good idea to know what's happening online.
*These five points are based upon select points in Currid's The Warhol Economy: How Fashion, Art and Music Drive New York City. Check out the book to learn more about how they relate to NYC's economy and social structure.
About the author
MPA. Chief Market Engagement Officer at IMPACTS Research & Development. Nonprofit marketer, Generation Y museum, zoo & aquarium writer/speaker, web engagement geek, data nerd, marathoner, nomad, herbivore


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Originally posted on NESN.com | Last updated 6/25/13
Anybody looking for a quick fix to the Celtics' opening for a head coach to help them move on from the Doc Rivers era will be disappointed. The Celtics are in no rush. With the NBA Draft just days away and summer league tipping off in a matter of weeks, the Celtics plan to take their time with hiring a new coach. Do not expect Rivers' replacement to arrive before mid-July, when the Celtics' summer league wraps up, according to Steve Bulpett of the Boston Herald. Source: Celtics prepared to take time w/coaching hire. Could take until after summer league, which, for Celts, ends July 12.— Steve Bulpett (@SteveBHoop) June 25, 2013 At least one prime candidate came off the market on Monday, when the Nuggets hired Brian Shaw as their coach. The list of experienced and up-and-coming candidates is shrinking every day, with Philadelphia also looking to fill the vacancy left by Doug Collins. The Grizzlies, who parted ways with Lionel Hollins, reportedly plan to promote assistant coach Dave Joerger. Check out some top candidates to be the next Celtics coach>>
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text: Jerk Salmon with Yoghurt Potatoes Recipes By Helen Schofield 10 May 2016 What's your plans for dinner this evening? If you need some inspiration for a healthy home-cooked meal, why not try this scrumptious "Jerk Salmon with Yoghurt Potatoes" recipe by food guru Helen from Scrummy Lane. According to Helen, "This recipe has a little bit of heat and a lot of taste. Just marinate the salmon in a spicy herb mixture, then pan fry and serve on a bed of yoghurt-y potatoes. With so many fresh and zingy flavours, this is one dish you simply have to try". Ingredients 350 grams / 12 ounces baby potatoes, sliced into about 1cm slices 1 small bunch each of parsley and coriander ⅔ teaspoon dried chili flakes 1 teaspoon allspice 2 cloves garlic, chopped or crushed 1 teaspoon black pepper ½ teaspoon salt a thumb-width-sized piece of fresh ginger, peeled and grated juice of 1 lime, plus lime segments to serve ¼ cup (60ml) olive oil 2 x salmon filets, skin on (each of mine were about 120 grams / 4.25 ounces) ¼ cup (70 grams) Greek yogurt 1 shallot, chopped finely (or 2 spring onions, sliced) Instructions Cook the potatoes until just tender (I boiled them for about 10 minutes), then drain, tip back into the pan and cover to keep warm. Put most of the parsley and coriander, the chili flakes, allspice, garlic, pepper, salt, ginger, lime juice and olive oil in a food processor and process to a chunky wet rub. Pour half of the mixture over the raw salmon and leave to marinate for about 5 minutes. Gently fold the rest of the mixture through the potatoes together with the yogurt and the shallot / spring onions. Cook the salmon in a frying pan / skillet on a medium heat, skin-side first, for a few minutes on the first side and about a minute on the other*. Divide the potatoes between two plates, and serve the salmon on top. Sprinkle with the remaining herbs and serve with lime wedges. Notes Adapted very slightly from Express by Australian Women's Weekly *Cook the salmon (undrained) until it's just cooked all the way through. You can see whether it's cooked by watching how the colour changes on the side of the fish. * Quick tip - place the salmon skin-side down in a hot pan, then reduce the heat to medium immediately. That way the skin gets nice and crispy without the salmon overcooking. Then when you flip it over you let it cook on the other side for about another minute only. If you remove it from the pan when it's just cooked it'll continue cooking slightly and be perfect by the time you've dished up. Enjoy! Tags: Healthy Tips Dinner Protein Category: Recipes « Back


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Spacious apartment well situated
Size106 m²
Floor No.4
- Family/child friendly
- Internet/WiFi
- Kitchen
- Washer/dryer
- Dishwasher
- Towels
- Parking available
Accommodation summary
|Præstøgade, 2100 Copenhagen, Denmark
|Property type
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
|A month ago
The apartment is located in the inner-most part of Østerbro (Embassy Quarter), a short walk from Østerport Station, Kastellet and Langelinie - providing you no real excuse not to pay the Little Mermaid a brief visit while you're here.The city centre is 15 mins. away on foot (or five minutes on bike - after all, this is Copenhagen!).
Østerbro is a safe and calm neighbourhood, but Rosenvængets Allé and Nordre Frihavnsgade (both just around the corner) offer a full range of cafés, shops, restaurants and wine bars (and the odd dive, should you wish to drink a Tuborg with the few remaining harbour workers in the area).
All-in-all a great apartment for two who enjoy plenty of space or four who'd like to be able to remain friends after having stayed in the same apartment on their holiday.
House rules
|Check-in after
|On arrangement
|Check-in before
|On arrangement
|Check-out before
|On arrangement
|Cancellation Policy
Reviews of this property
Luise is very good stuff. The location of the apartment is super, very clean and comfortable. Thank you for everything.
the contact with louise was very nice, very reliable and the appartment was very fine! anytime again!
Wonderful apartment and wonderful host. The apartment is very stylish and Louise was so helpful. I would stay again for sure!
Very friendly answered quickly ... I recommend for sure, the apartment is very comfortable ... close to everything ... Thank you very much Louise!
Very friendly answered quickly ... I recommend for sure, the apartment is very comfortable ... close to everything ... Thank you very much Louise!
Our stay in Copenhagen was absolutely the best! The apartment was spacious, clean, and felt like home. Everything was there that we might have needed. Even the wifi worked great. It is in a wonderful neigborhood and close to the Osterport train station. We walked into Indre By (center) no problem, if you enjoy a good walk.
Louise was a fantastic host. Everything went very smooth considering we arrived late due to delayed flights from the US. And had limited wifi to communicate.
It was a very special experience and I left wishing I lived there...
Thank you again Louise xo
A great apartment in a lovely safe area, welcomed by Louise who pointed us in the right direction and we where able to walk to all the main attractions. Loved the city and loved the apartment, thanks Louise
The apartment met our expectations fully and we have
the amenities enjoyed. The rooms are very well and lovingly
equipped. Neat and tidy. Its location in the district and especially the
Street are a very good starting point for urban enterprises.
Die Wohnung hat unsere Erwartungen voll und ganz erfüllt und wir haben
die Annehmlichkeiten sehr genossen. Die Zimmer sind bestens und liebevoll
ausgestattet. Ordentlich und gepflegt. Die Lage im Viertel und vor allem die
Straße sind ein sehr guter Ausgangspunkt für städtische Unternehmungen.
We had a great holiday in Apartment Louise Muffs. Beautifully appointed
Altbauwohnung. The apartment really looks like the pictures.
Had 2 nights booked and were with our 2 children there.
We liked it very much. The sights and the downtown
are well within walking distance. (Especially the little mermaid).
Even with the parking we had no problems. Directly in front of the house,
However, with a parking permit.
Wir hatten eine super Urlaub in Louise Muffs Wohnung. Schön eingerichtete
Altbauwohnung. Die Wohnung sieht wirklich so aus, wie auf den Bildern.
Hatten 2 Übernachtungen gebucht und waren mit unsern 2 Kinder dort.
Es hat uns sehr gefallen. Die Sehenswürdigkeiten und die Innenstadt
sind gut zu Fuß zu erreichen. ( besonders die kleine Meerjungfrau).
Auch mit dem Parken hatten wir keine Probleme. Direkt vorm Haus,
allerdings mit Parkschein.
Very nice apartment, bright, beautifully furnished and decorated, with all amenities; near the Little Mermaid and the promenade along the waterfront into the city center. Central enough location to do everything on foot (or by bus back, if necessary) ... Thanks Louise ..
Appartement très agréable, lumineux, joliment meublé et décoré, avec toutes les commodités; proche de la Petite Sirène et de la promenade le long des quais jusque dans le centre-ville. Emplacement suffisamment central pour faire tout à pied ( voire revenir en bus, si c'était nécessaire) ... Merci Louise..
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Measure, cut, and shape wood or other materials to assemble or repair structures. Some carpenters build larger-scale building frames. These projects require them to work effectively and efficiently with cranes and other large machinery to raise, level, and fix the skeleton in place. Other carpenters may install particular fixtures, including cabinets, siding, drywall, and wainscoting. The exact materials they use depend on the companies they work for.
All carpenters must be competent at reading blueprints and building plans in order to properly complete construction to the client's specifications. They may also be responsible for inspecting and replacing damaged frameworks or fixtures. They rarely work from an office, and are almost always performing labor on-site.
Tradesmen International - Trumbull, CT
We are looking for Journeyman Carpet Installers in Connecticut area PAYS: $18-20/hr HOURS: 8 hr days/ 40+ hours a week. *Must have a valid driver's license and reliable transportation* Experience...
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20 days ago
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The concepts of green building and sustainability are very popular right now in construction and elsewhere, but they go beyond installing new windows or smart thermostats.
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BI Developer at Quiglies Solutions
Permanent Intermediate position
Bellville, Western Cape
Market Related cost to company
Job 1596841 | Ref SS0016
Posted 09 Jan 2017 by Quiglies Solutions
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