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Title: If You're Not Breathing, Why Am I?
Author: Bernarde
Rating: NC17
Summary: HARDYCEST. Jeff knows his time is short, and he has a confession for Matt.
Note: The title for this song, and indeed the inspiration, came from the song "House Carpenter" by Hurt. I can't listen to it without tearing up.
Disclaimer: I own nothing and claim no knowledge of anyone's sexual preferences other than my own.
He sat staring at the sight before him, his body barely noticing the plush chair beneath him or the sobs of the others. The words of the priest whispered through his head, and he didn't feel Shannon's hand on his shoulders. He didn't know if he was crying or not. He didn't know anything, really. It felt like every emotion he could possess was now stored in the elaborate box before him. No, not a box. Casket.
The images in his head swirled and melted together, forming pictures for a brief moment before dissipating again. None of them lasted more than a few seconds, until one stayed: the last time he had seen his brother alive.
He had come back to the house from the grocery store with eggs and vanilla extract because Jeff had expressed a vague desire for French toast. They both knew he wouldn't be able to eat it, but it was the thought that counted.
"I'm back," he called as he set the eggs in the refrigerator. He heard shuffling from the spare room, "Jeff...?" Matt walked over and ducked his head into the door. Jeff was on the bed, as he had been for awhile now, a teal bandanna wrapped around his head, and his face buried in a handful of blankets. Immediately concerned, Matt sat beside him and placed a hand around his shoulders. Jeff shrugged him away and then let out a gut-wrenching sob that Matt didn't know was possible of coming out of him. It tore at his heart and he tried again to take his weeping brother into his arms.
"Jeffrey... talk to me," he whispered softly, but Jeff actually slapped him away this time. It wasn't a hard movement - Jeff wasn't capable of that much anymore - but it was intentional.
"No. No. I'm a horrible fucking person," Jeff wiped his eyes on the back of his hand and refused to look at Matt, instead staring to the other corner of the room.
His face, like the rest of his body, was gaunt, the skin taut and pale. He looked nothing like he had even a year ago. The cancer had set upon him fast, furious, and unexpected, the way Jeff himself had always been. Chemo had left him completely hairless and weak, and had failed to destroy the malignant cells within him. Told that he only had a few months left to live, he refused to stay at the hospital and asked to stay with Matt. He had his painkillers, lots of them, but that was it. People visited them often, especially Shannon and Shane; usually they brought marijuana to help Jeff relax and actually eat something without throwing it back up.
Matt felt his heart sink at seeing Jeff so upset, trying to stay the strong one, trying to be the rock for his brother like he always had been. He set a hand gently on Jeff's arm, "Do you want me to leave you alone? Talk to me."
"Stay," Jeff whispered. He looked down, and then let his hand rest on Matt's. "Matt... there's something we need to talk about." The older one nodded, rubbing his fingers on Jeff's skin. Jeff swallowed thickly. "I love you." There was a pause.
"Well, I love you too... I mean, you're my brother," Matt's brows knitted together as he studied the blank look that came over Jeff's face.
"It's... it's more than that, Matt."
"Don't tell me you've never felt it!" Jeff's mood switched 180 and he finally faced his brother, eyes blazing in a way that Matt hadn't seen in months, "Don't, Matt. I know you have!"
Matt stared at him, his face a mixture of confusion and perhaps a trace of fear.
"Felt what, Jeff?"
Jeff rubbed his forehead and tried several times to talk, each attempt ending in an exasperated sigh. He looked at Matt with frustration written all over his face, and the anger in his eyes sparked again.
The younger brother then snarled like an animal and grabbed Matt by the hair, pressing their lips together in a quick, brutal kiss. Matt didn't pull away, but he didn't respond either. They ended up still staring at each, Matt with his mouth slightly open, and Jeff shaking with emotion.
Matt's eyes became glassy and he turned away, and Jeff knew that he had him.
"I have, Jeff... I have felt it. And I've ignored it," Matt paused, "It's wrong."
"And you know what else is wrong? Us bathing when others have nothing to drink. Us living here in the goddamn lap of luxury while others live on the street. Hell, this fucking cancer is wrong. But we can't change that. Matty..." as quickly as it had come, the anger went out of Jeff again, "I've loved you since I was born. I've always hidden it, because I knew you wouldn't accept it... but Matt, I couldn't bear dying without letting you know." His stopped, choked up with tears, "It's nearly the end for me. I know it, you know it. Please... just..." Jeff couldn't talk anymore, and he let his sorrow run down his hollowed cheeks.
Matt sat there, eyes clenched shut, listening to his brother cry, and felt all the feelings he had kept bottled up for decades pull at him. They had been buried so deep he had nearly forgotten about them, but Jeff's confession and the kiss... it was all brought back.
The two of them had always been quite close, and he knew it had been abnormal, but he had just dismissed it... until he realized it was deeper than that, and then he closed it up all the more fervently.
He was thrust out of his reverie when he felt Jeff trying to climb onto his lap. He shifted to take Jeff's place on the bed, letting Jeff crawl onto him. His strong arms wrapped around the slight frame, and he held his beloved tightly to his chest.
A cool cheek pressed to his and he felt Jeff's lips on his own once again. This time he fully accepted the chaste kiss, letting himself return the action. Jeff whimpered softly and broke it, then nuzzled Matt's neck, pausing to brush his lips against Matt's ear.
"Please... make love to me, Matt..." he whispered, "This one and only time." Matt didn't answer, and Jeff feared that his brother might leave. But then he felt hands on his sides and Matt was kissing him again, slowly and passionately. A warm tongue stroked his lip and he opened, letting Matt taste him.
Finally allowed to touch the man he had always loved, Jeff let his hands roam over Matt's face, neck, shoulders, thread through his hair... he pulled the elastic out and relished the feeling of the silky smooth strands running through his fingers.
It took only a few minutes for Matt to lay Jeff down on the bed, kneeling above him as he kissed him tenderly. His own callused fingers ran over Jeff's cold flesh, somewhat unnerved at the feeling, but there was a fulfilling sensation at knowing it was Jeff. His Jeffrey. The man that he had protected for his entire life, the boy that he had been there for, until something neither of them could see took his little brother over from the inside.
They kissed softly for what felt like hours until Jeff's fingers started pulling at the hem of Matt's t-shirt. He looked up into Matt's face, his eyes pleading, until Matt obliged and took it off. From there it was like a candle melting, and their clothes fell away piece by piece until both were nude.
Matt kissed down Jeff's collarbone, tracing his hands over the thin chest, before shifting down. He felt somehow alive and yet numb, knowing that this would be the one and only time they would ever be able to do this.
Jeff spread his legs to let Matt kneel over him properly. Clammy palms clasped over Matt's shoulders and Jeff looked deep into his brother's eyes.
"I love you."
"I love you, too."
The sun had set during their fondling, and the room was dark now. The only light was from a dim lamp in the other corner of the room; it was too cloudy for the moon to shine through tonight. There was a breathy gasp as Matt slid saliva-slicked fingers into Jeff's willing body, finding heat within that he didn't imagine was still possible. They kept eye contact as he stretched his brother, emerald melting into obsidian. Jeff kept his breath as steady as possible, then shifted.
"Please," he whispered. Matt nodded and they moved again, Jeff lifting his legs to rest his calves on Matt's strong, broad shoulders. Matt wrapped a hand around his shaft, pumping so that he was fully hard, then moistening himself with as much spit as he could. Finally, resting his weight on his arms, Matt pressed himself forward.
"Relax, Jeff..."
"I'm trying."
A keening sound echoed as Matt slipped in, slowly and steadily. Jeff cried out again as Matt nestled fully into his body. The older brother moaned at the warmth surrounding him, the sheer tightness enough to drive him mad, but he forced himself to remain still. Then Jeff moved his hips and he knew it was okay, and started to thrust gently.
"I love you so much, Matthew. I can't..." Jeff's voice dissolved into sobs, and he clung to Matt's body tightly. Matt could feel his resolve breaking, could feel it weakening bit by bit under waves of pure emotion. Every tear he had wanted to shed during this whole situation stung at his eyes, and he couldn't hold it back anymore.
Then it broke, and the stone angel cried at last.
Jeff forced himself to take Matt deeper, begging his brother to break him. He marveled at the sight of Matt crying, and knew deep within himself that this was the end.
When Matt came, Jeff had become so weak that he could barely move anymore. He snuggled into Matt's powerful chest, feeling arms wrap around him and hands stroke his neck and bare scalp; the bandanna had fallen off long ago. He clung tightly to his beloved, and kissed him one last time as sleep beckoned him.
"I love you, Jeffrey," Matt said, strong and sure.
"I love you, Matthew. Forever."
The next morning had found Matt entwined with a body; Jeff had departed in the night.
They both knew he would.
He had called Shannon first. There was no immediate family left to call - Gilbert had passed on years ago. Shannon had come over and made the rest of the necessary plans. Matt had withdrawn so deep into himself that it seemed there wouldn't be any way out for a long, long time.
"Matt? Are you ready?" Matt came to looking into Shannon's face.
"Yeah." His voice was cold and hollow. There were no more tears left. He stood slowly, and saw that everyone else had left. They were the only two there. Them and Jeff's casket.
Matt stepped forward and kissed the smooth wood.
"I love you, Jeffrey," his voice stayed true, and he let Shannon lead him to the car.


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PRESS DIGEST - Wall Street Journal - July 9
July 9 (Reuters) - The following are the top stories in the Wall Street Journal. Reuters has not verified these stories and does not vouch for their accuracy.
* President Barack Obama is seeking $3.7 billion in funding and legal changes to stem the surge in children and families illegally entering the United States, creating new tensions within his party as he works to confront a crisis that is overwhelming the government's ability to hold young migrants. (on.wsj.com/1jnW60X)
* Israel stepped up its attacks in what it called the beginning of a prolonged assault on Palestinian militants and their infrastructure in the coastal enclave. (on.wsj.com/1xPSRlO)
* Medicare allowed $1.7 billion in 2010 payments to clinical laboratories for claims that raised red flags, according to a report to be released Wednesday, the latest example of how the federal insurance program for the elderly and disabled is susceptible to misspending and abuse. (on.wsj.com/1ncG2P0)
* The Justice Department and Citigroup are close to a deal for the bank to pay about $7 billion to settle allegations the bank sold shoddy mortgages in the run-up to the financial crisis. (on.wsj.com/TRFG4t) Continued...

subset: commoncrawl


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Rue Mouffetard Vacation Packages
To appreciate the many textures of Paris, pull on some comfortable shoes and discover surrounding areas like Ile de la Cite, Paris, and Ile Saint Louis.
Travelers come from near and far to see the Eiffel Tower, one of the most photographed sites in the country. It is only 3 miles (5 kilometers) from the middle on the city.
Investigate the Arc de Triomphe and Louvre Museum and spend a while longer in Paris's city center.
Rue Mouffetard has plenty of cultural attractions nearby that make great places to visit. Visit the various museums and galleries of Picasso Museum, the Arab World Institute and the Musee du Luxembourg. Enjoy seeing local and touring talent live on stage at Bobino, Opera Bastille and Bataclan. The area is a dream destination for art lovers. Visit the Cartier Foundation for Contemporary Art and the Gallery of Comparative Anatomy and Paleontology.
If the weather is good get outdoors and make the most of the nearby parks and reserves. Rest a while and enjoy the sunshine in public parks and gardens such as Parc Montsouris.
Sights such as Palais Royal, the Luxembourg Gardens and the Pont des Arts make great places to visit while you are in the area. See some places of worship such as the Notre Dame Cathedral, Eglise Saint-Eustache and the Church of Saint Germain l'Auxerrois. Admire the beautiful craftsmanship and get a deeper understanding of the role of religion in the area.
For some retail therapy, visit the Le Bon Marche, the Forum des Halles and Bercy Village.
At the end of a busy day exploring the streets of Rue Mouffetard, relax for the night at one of the area's bed-and-breakfasts, hotels or short-stay apartments. Check out the rooms and rates at the Pullman Paris Montparnasse, the Novotel Paris Gare Montparnasse, or the Novotel Paris Les Halles.


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Stock Image
Bibliographic Details
Title: la protection sociale complementaire ...
Publisher: LAMY
Book Condition: New
New. Free USPS tracking number for US destinations. This item is shipped from France. Bookseller Inventory # 2721214926-9782721214928
Payment Methods
This bookseller accepts the following methods of payment:
AbeBooks Bookseller Since: 16 December 2015
Bookseller Rating:
We accept returns up to 30 days after reception of the item. DVD, CDs, Blu-rays must be unopened (please pay attention to the region of the item)
We deliver in the US within 2-3 weeks.
Store Description: Dear customers, we are at your service if you have any questions. We hope you will enjoy the item(s) you receive from us. Best regards, Mike


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Flora, fauna, and folks on San Luis Rey River bike trail
A quiet ride along the river
The Canyoneers 10 a.m., May 24
Paul Barbano explains the basics of backyard chickens. Discussion includes legality; breeds; where to start; housing and outdoor pens; feed, water, sunlight, and shade; and common chicken problems. Handouts provided.
230 Quail Gardens Drive, Encinitas, 92024
Get directions
Please log in to submit event corrections


text:
|Taking The Headaches Out
of Internet Marketing
|In this issue:
I've been working this week on report designed to help you make money with your blog.
Regardless of your particular blog focus, this report will help you understand how money is made and how you can apply it to your blog.
Check out the free report here:
Blog Tips… To Help You Make Money Blogging!
Pre-Announcement for T.E.A.M. Ebook Giveaway Series
This is an upcoming community project that I sincerly hope you will come take part in!
A chance for some viral exposure, some quality content to give to your list and a chance to get to know some bloggers you probably haven't met!
Click the link to find out more!…
MaxBlogPress Is Celebrating Christmas With A SALE! With the start of Holiday Season, MaxBlogPress has their most INSANE DEAL of 2010
From 7th Dec till 14th Dec Midnight, you can get the best selling MaxBlogPress products [worth $475.00] at 70% OFF.
Check it out http://just-ask-kim.com/recommends/mbpxmas(affilliate link)
Random Facebook trivia:
60+% of people online use Facebook to stalk their ex! Now are you one of them? You can minimize stalking behavior by temporarily tightening your security permissions and reducing the revealing information you post as wall posts or replies on mutual friends pages/posts.
Most Common Commentluv Mistake.
Be sure you make plans to get your blog up onto 3.0.3 THIS WEEK…
The last two updates have been moderately serious security updates due to exploits (ie: "hackings") occurring!
Please get those blogs upgraded and if you have questions just ask!
Two Posts To Help:
How To Back Up WordPress Correctly!
Making PLR Make Sense – A Guide For Bloggers
Nicole Dean Shares Answers To The Most Common Questions About PLR – which stands for "Private Label Rights" and is one of the biggest timesavers! read more
The Most Common Question About Ad Swaps
Ad Swaps Should ALWAYS Be Mutually Beneficial The most common question I hear among my friends and students about ad swaps is a fear that they will end up getting put into a bind to mail something to their list that is not up to the right quality, caliber or even just not being a … read more
Do Pop-Ups & Pop-Unders Affect SEO Ranking?
Google Answers The Tough Question… About How Pop-Ups Impact SEO There is a lot of mis-information floating around about the impact that pop-ups have on SEO so this is an important video!… read more
The Official Top 50 MLM Blogs for 2010
Meet Network Marketing's Best of the Best! The final tally is in and the top 50 blogs of the network marketing (MLM) industry are in!… read more
Facebook Profile Picture Box
The new picture boxes at the top of the new profiles work by displaying photos you are tagged in.
To add photos, tag yourself in some.
To delete (from the picture box only) a particular photo (useful to find the ones you want!) hover over the image and select the little "x" that appears.
I invite you to connect with me throughout social media! Lets get to know each other!
"Pray that success will not come any faster than you are able to endure it."
– Elbert Hubbard
|Copyright © Just-Ask-Kim.com Kimberly Castleberry
Just Ask Kim Newsletter 12-13-10


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ED Magedson – Founder
Ripoff Report
Kleargear.comInternet USA
Kleargear.com Klear Grear is responsible for taking what is not theirs, they are currently sue an individual that complained about their service. Klear Grear seems to be following in the footsteps of Monsantos Corporation ion stealing land and livelihood from the common citizen. Internet
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
Kleargear.com is acting irresponcible and taking things that are not theirs to take. The company is sueing a customer for complaining about their service.
It is recomended that NO business be done with this company.
You will order and they will not deliver. You complain and they sue you. For thousands of dollars; much more than you spent.
This company is decietful in practice and should be avoided.
This report was posted on Ripoff Report on 11/18/2013 09:46 AM and is a permanent record located here: http://www.ripoffreport.com/reports/kleargearcom/internet/kleargearcom-klear-grear-is-responsible-for-taking-what-is-not-theirs-they-are-currentl-1100265. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
Click Here to read other Ripoff Reports on Kleargear.com
If you would like to see more Rip-off Reports on this company/individual, search here:Search Tips
In order to assure the best results in your search:
#1 Consumer Comment
Update on Terms of Use
SUBMITTED: Friday, January 03, 2014POSTED: Friday, January 03, 2014
They no longer have this clause in the terms of use. They must have removed it after the small "controversy."
Are you an owner, employee or ex-employee with either negative or positive information about the company or individual, or can you provide "insider information" on this company?
#2 General Comment
SUBMITTED: Wednesday, December 04, 2013POSTED: Wednesday, December 04, 2013
I find it incredibly funny actualy. Its in the ToS. Which NO ONE READS!!! So once again the American Consumer has allowed themselves to be boned. Basically anyone that uses that site has the potential for the fine. Mainly because they didnt read the ToS and blanket agreed to it. So in essence, the users of that site have given the permission to sue.
Are you an owner, employee or ex-employee with either negative or positive information about the company or individual, or can you provide "insider information" on this company?
Advertisers above have met our
strict standards for business conduct.


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Microsoft is reportedly testing an Office Outlook client for Windows RT devices which will bring the functionality of Outlook software of Office to Windows RT users.
Although, Windows RT has its own Office known as Office RT but, it doesn't include the Outlook application which leaves the Windows RT users with the pre-installed Mail app which comes with limited functionality only.
Now, ZDNet reports through sources that Microsoft is testing a Windows RT version of Outlook which will bring all the functions of Outlook for x86 devices to ARM based Windows RT.
Although, Microsoft is testing the Outlook on Windows RT devices but, it's still unknown whether it's an Windows 8 style app or it would be included in Windows RT like Office RT.
ZDNet also reports that there is a debate going on in internal Microsoft divisions where some wants to bring Outlook to Windows RT while others don't. But, the software giant isn't disclosing anything officially and also, there are chances that these Outlook testing may remain internal forever and public may never see Outlook on Windows RT devices.
Source: ZDNet


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Career Opportunites at Advanced Integrative Medicine:we are looking for a Physician Assistant or a NP for our after hours and weekends.
Advanced Integrative Medicine is excited to announce:Extended hours! We will now be open until 8pm Monday-Friday and Saturdays 8am-12pm New Providers! We are pleased to announce the addition of Dr. Christine Jones, DO, Dr. Raquel Litherland, DPM and Dr. Diana Milling, ND. New Services! We have added Podiatry, Naturopathic Medicine, and Allergy Testing. Make Your Appointments Now!
Advanced Integrative Medicine is looking to grow!
We are very excited at how well we have been received in our community and we are now looking to expand! We are now interviewing for Internists, Physician's Assistants and Osteopath's wanting to be involved in a leading medical office that offers alternative options to our patients. This is an excellent opportunity for someone who wants an unlimited possibility for income. Please call the office at (303) 708-0246 or email us your resume at firstname.lastname@example.com if you are interested. We are also OPEN to New patients!
Mission Statement
Advanced Integrative Medicine's primary goal is to provide our patients with team based health services that combine Western (Allopathic) medicine with complementary treatments in a modern setting emphasizing integrated treatment modalities.
We believe that your active involvement with our providers who are Board Certified in Internal Medicine and Family Practice along with two highly trained Physician Assistants are essential to your personal health and wellness.
In addition, our professionally licensed health care providers in Clinical Psychology, Diet and Nutrition, Chiropractic, and Acupuncture services work closely together with our traditional medical providers…MORE
Contact Details
Advanced Integrative Medicine
10455 Park Meadows Drive
Building 1, Unit 102
Lone Tree, CO 80124
Phone: 303.708.0246
Fax: 303.708.0247


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So you fancy yourself the technical advisor out of your clique? Are you the person your friends and family call when anything technical is hurting their head? Maybe you just love free applications! If either or all three of these statements are true then The Tech Toolkit 2.0 is for you!
I am talking everything here. They have the best free applications for everything including anti-virus, virus/spyware removal, password recovery and even DVD burning. The magic behind this baby is that it comes with a downloader so that you can use your jump drive to launch a program. That program grabs the latest and greatest versions of a whole bunch of portable tools. With that same program (Ketarin) you can keep your applications updated as well.
Once you download the zip file from here you then extract those files to your memory stick. Then you launch the application called Ketarin.exe which you can see it below in this screenshot.
After launching Ketarin you will get a screen that looks like this:
You can right click on any of the items and delete it. The right click context menu looks like this:
You add a new web application by hitting Add new application. You need either the URL or a FileHippo ID (I wrote about File Hippo here FileHippo Update Checker Keeps Your PC Software Updated FileHippo Update Checker Keeps Your PC Software Updated Read More )
Once your list is set up the way you want, click the Update Now button. These are your available options:
I hit Check for updates and download. The program took off and grabbed all my applications. Some of them are password crackers and most antivirus programs will tag them as Trojans. They are in a way – they can harvest passwords but for good and not evil. But if that scares you do not download these applications! The downloads completed and my stick was ready to go.
I opened up my memory stick and saw a launcher application. I double clicked on it and was greeted with this:
When you expand all the categories there are a HELLAVA lot of applications here is the full list:
Everything but the kitchen sink! From Malware Bytes Stop & Delete Spyware With Malwarebytes for Windows Stop & Delete Spyware With Malwarebytes for Windows It may not be as feature-laden as Spybot Search and Destroy, which has a ridiculous number of tools, but it is a very lightweight alternative with good spyware coverage. Read More to FoxIt 4 Very Light Alternatives to Adobe Reader 4 Very Light Alternatives to Adobe Reader Are you still using Adobe Reader for PDF documents? It's time to move on to an alternative PDF reader that is lightweight, launches quickly, and yet keeps your documents save. Read More and back over to Gspot Play Any Movie You Donwload Using Gspot & Klite Play Any Movie You Donwload Using Gspot & Klite Read More . I can use my jump drive to do almost anything with this kit, from recovering a system to burning a CD/DVD. If you love free software, this one is for you! Every application downloaded, I totaled 270 MB of power packed tools.
What do you have on your memory stick? Share it with us in the comments!
Leave a Reply
interesting article
A-squared FREE USB Stick version is an outstanding virus and malware scanner, designed to be run from a USB stick:
Since the large download contains all of the updated signature files, I download afresh version frequently.
Freeware! Contains a-squared Free and a-squared Commandline Scanner files. Unpack the zip to a USB Stick to make an easy to use scanning and removal tool.
This file is kept always up to date with the latest program and signature files. For Windows XP, 2003/2008 Server and Vista, limited functionality on x64, 53 MB
Best way is build your own - but that does take time. I took three days to load almost 250 apps on one of my 4GB USB keys. But I've got a lot more than this list, including the full OpenOffice. I've got pretty much everything on this list, minus a few password viewers and the like, but I've got a lot more from my collection of over a thousand utilities.
But this is a good way to go for people who don't want to take the time to manually build an "all-in-one" utility key.
Next step for me is to put UBCD4Win on a key, plus a Linux distro, plus a Linux security distro. Those, plus my "reference" key with tons of ebooks, plus my "standard installs" key, will keep me prepared for anything I run across in doing tech support.
Can you share your list of apps? I have actually done quite a large research but while most of the apps that are included in the list are known, there are as well surprises. Currently I´have use as sources (besides my own searches):
the suites, like liberkey, lupepensuite, winpenpack, winizio
as well as other collection like the stated above, and finally worth mentioning the techsupportalert-gizmo selection of portable apps.
In my stick I got 200+ apps but they are strictly selected.
PD: can you make a list with directory lister?
I'll admit I've heard similar stuff about Liberkey - but to be honest it is a brilliant app - the auto updater is second to none!
@jgh : First time i hear about that..
Actually, what's illegal in turning free apps into portable ?
I like the way Liberkey apps can be updated. Much more easier than Portableapps for instance..
I also use Cody with their apps. http://codyssey.com/products/codysafe.html
Do you have any justified reason to smear this bullshit? I do not use Liberkey, but not because some morons are saying that they are bad.
Did you ever read the source code of any open source apps? Or you trust the world "open� Does it make you feel better?
Liberkey have made mistakes in the past, no doubt about it. Also it can´t give you the same trust a closed source. I have read the source code of some open source apps, and more important, I trust the comunity of developers who check them and yes it gives more trust and transparency.
Anyway, beside that I think Liberkey is a very good contribution to the portable world, and no, I don´t think neither their closed source is crapware.
Ugh, Franck. Don't use liberkey. Most of the apps in there are included illegally and they've stolen code from portableapps.com many times in the past and then lied about it. Who knows what other nasty things lie in their closed source crapware.
Also check out portableapps
I use KSPF (Kitchen Sink Freeware Collection). http://kitchensinksoftware.blogspot.com/
It includes every single useful application that is portable and strictly follows the rules given in http://www.portablefreeware.com/
Actually there's three programs, TightVNC Client and Server and WinSplit Revolution, which has not been accepted by the PFC community.
So its about 98% compliant.
Thanks for posting about it. :)
Thanks that looks really useful!
I use liberkey also & like this one too - Codyssey
Nice one !
I love USB + free apps too so i'm using Liberkey : http://www.liberkey.com/en/


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The central role played by the City in international finance has, over the years, led many law firms from around the world to establish offices in London.
For Irish law firms, the motivation to establish in London has been all the stronger given the substantial trading links between the two countries and their geographical proximity.
Irish firms flourished in the city during the boom years of the 1980s. They were largely insulated from the worst effects of the early 1990s recession because they had expanded less rapidly than their UK counterparts and were also helped by the development of new initiatives in Irish financial and industrial fields.
The successful establishment and growth of the International Financial Services Centre in Dublin, for example, led to a new flow of work from clients, in the UK and elsewhere, wanting to establish themselves in and operate out of the centre.
Broadly speaking, there are three primary functions performed by the London offices of Irish firms. They advise Irish clients doing business in the UK or with international institutions based in the UK; they advise UK-based clients doing business in Ireland; and they also play an important role in maintaining contacts with existing clients and developing new relationships.
The emphasis placed on each of these three areas differs from firm to firm. For example, this firm opened its London office in the mid-1980s to cater for the rapidly expanding volume of work it was doing for institutional and other clients in the UK. It concentrates on advising UK-based clients doing business in Ireland, so its lawyers only practise Irish law. And although business development is an important part of the firm's overall role, it is secondary to its client work.
The London office concentrates solely on commercial work, but the range of that work is very broad, encompassing mergers and acquisitions, general corporate, corporate finance, venture capital, securities, banking and financial services.
Over the past year the office has experienced a marked upturn in corporate finance and mergers and acquisitions work, including its involvement as Irish lawyers to Atlantic Richfield Company (ARCO), which attempted to take over Aran Energy last summer.
While the office operates independently of the main office in Dublin, work flows can be regulated either by referring matters back to Dublin or, alternatively, bringing additional lawyers over to the office to work on matters requiring additional manpower. This is all part of the flexibility essential to the efficient functioning of a branch office.
One of the main advantages of having an office in London is the ability to meet with clients at short notice. The firm has found that many clients prefer having their lawyers present at important meetings rather than them being on the other end of a phone line.
The London office operates as a satellite of the main practice in Dublin and has the benefit of its administrative, accounting and library facilities. The use of a modem link also facilitates the immediate transmission of documents between the two offices.
The firm rotates the lawyers working in the office as new people every two to three years bring fresh impetus and enthusiasm to the role.
A&L Goodbody's London office plans to continue much as it has done since its foundation. The set-up works well within the overall direction of the practice and has proved it has the necessary flexibility to adapt to changes in the market.


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Simple, Sophisticated Valet Tray
You've got your keys, jewelry, loose change and wallet that all have to be stored somewhere. Why not get this Simple, Sophisticated Valet Tray? Not only is it the perfect tray for all of those things, it is also a great Father's Day Gift.
This is a classic, no-nonsense, handmade, desk accessory statement piece that is fabulous in either cherry wood or walnut.Tags: office, mens, work, professional, gadgets, desk, home office, organizers, organizeAdded 9 Years Ago from Delight.com


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From the Asthma and Airways Centre, University Health Network, (Drs L. G. Fritscher, Marras, and Chapman and Ms Bradi), and the Asthma Education Clinic, Mount Sinai Hospital (Dr Balter), University of Toronto, Toronto, ON, Canada; the Pontifícia Universidade Católica do Rio Grande do Sul (Drs L. G. Fritscher and C. C. Fritscher), Porto Alegre, Brazil; the Universidade Luterana do Brasil (Dr L. G. Fritscher), Canoas, Brazil.
Correspondence to: Leandro G. Fritscher, MD, MSc, Avenida Ipiranga, 6690/501, Porto Alegre, RS, Brazil; e-mail: firstname.lastname@example.com
Funding/Support: The study was partially funded by an unrestricted grant from the Imperial Oil Foundation, which provided funds in order to explore new diagnostic methods in asthma and airways diseases.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).
© 2011 American College of Chest Physicians
Symptomatic disease due to nontuberculous mycobacteria (NTM) is known to occur commonly in the presence of structural lung disease, but is not described in association with asthma.
This was a case-control study nested in a cohort. We identified 22 patients with difficult asthma referred to a tertiary academic referral center and subsequently found to have infection with NTM. We matched each case with two control subjects (next two consecutive patients referred for asthma management).
It took on average 2.1 years from the onset of new or worsening symptoms to NTM diagnosis. The most common symptoms were worsening cough (77%), sputum production (40.9%), and frequent exacerbations (31.8%). Mycobacterium avium complex accounted for 63.6% of the infections, Mycobacterium xenopi the balance. Case subjects were older (59.8 ± 8.9 vs 42.6 ± 18 years; P < .001) and had more severe airflow obstruction (FEV1, 57% [40%-74%] vs 89.5% [80%-98%]; P < .001). There was no difference between case and control subjects in the proportion using inhaled corticosteroids (ICS) or the average daily dose at the time of presentation, but case subjects had used ICS for a longer period (17 [6.2-20] vs 4 [0.75-6.0] years; P=.002). Six subjects with NTM were being treated with daily oral steroids, whereas none of the control subjects was. Of the 22 cases, 10 were treated with antibiotics for NTM, seven demonstrating clinical improvement or resolution of the presenting symptoms.
NTM infection can be associated with asthma and should be considered in difficult-to-treat disease, especially in older individuals with more severe airflow obstruction and greater exposure to inhaled or systemic corticosteroids.
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You are here
The cost per patient of deviations from evidence-based standards of oncology care.
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^).
Background: Practice variation contributes to the high cost of healthcare and wasteful spending; by contrast, adherence to evidence-based (EB) clinical guidelines is advocated to improve quality and potentially lower cost. We sought to estimate the average cost per patient associated with unjustified deviations from EB national standards for use of chemotherapy, supportive drugs, and radiotherapy. Methods: The ITA Partners/eviti, Inc. database of oncology treatment plans (TPs) reviewed for payers for adherence to national guideline recommendations (e.g. ASCO, ASTRO, NCI, NCCN Compendium, FDA) was used to calculate the variance in cost between submitted TPs with unwarranted deviations from EB standards and EB care. For prospective reviews, the final EB treatment given was known and for retrospective reviews, the variance was estimated based on the EB alternative with the lowest cost. AWP pricing was used to calculate chemotherapy and supportive drug costs, and Medicare pricing for radiotherapy. First order savings were calculated. An annual trend of 8% was applied from the mid-data period to 2013 (Milliman Client Report 2010). Results: From March 2009 to March 2012, a total of 2775 consecutive patients had TPs submitted and of these, 730 patients had unjustified, non-EB TPs. All cancer types, stage and treatment intent (curative, non-curative) were included. The cost of EB treatment was less than the submitted TP for 622 (85%) patients, more for 9 (1%), and zero (could not be taken due to payer plan definitions) for 99 (14%). Descriptive statistics for the cost per patient of non-EB TPs trended to 2013 showed: mean $25,579, median $13,882, standard deviation $40,958. Conclusions: In this unselected population comprising all cancers, 26% had TPs that did not conform to EB standards or could not be medically justified. Our conservative estimate of the average per patient overspend (first order) on inappropriate treatment validates the potential for quality care to lower cost and deliver huge value to patients, physicians, and payers.
|Lower bound
|Upper bound
|Radiation therapy
Abstracts by A. A. Forastiere:
- Meeting: 2011 ASCO Annual Meeting | Abstract No: 5576
p16 protein status and response to treatment in a prospective clinical trial (ECOG 2303) of patients with head and neck squamous cell carcinoma (HNSCC).Meeting: 2011 ASCO Annual Meeting | Abstract No: e16032


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The short-short story is an exercise in virtuosity that tightens the circle of mystery surrounding what we know. John L'Heureux
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Will My Lower Poles Fill Out? (photos)
Doctor Answers 6
Lower poles not filling?
The lower poles do not fill out that fast. It takes more time for things to drop and fluff. You do look great for just 3 weeks. Continue to massage and speak with your plastic surgeon about your concerns.
Best wishes, Dr. ALDO
Breast Implants/Breast Augmentation/Anatomic Gummy Bear Implants/ Silicone Implants/Breast Implant Revision Surgery
I appreciate your question.
Right now, you are very early on in the post op recovery period. It will take 3-6 months for you to feel comfortable having implants in your body and for them to settle. This time allows for you to physically and psychologically adapt to your new body image. There are many variables that contribute to a breast augmentation's final result. Preop size and shape, IMF location, location of the implants and type of implant. Patients heal at different rates and each breast will sometimes heal at a different rate. Rest, relax, recover and heal. Express your concerns to your surgeon so he/she can examine you. Then reassess final result at 6 months.
The best way to assess and give true advice would be an in-person exam.
Please see a board-certified plastic surgeon that specializes in aesthetic and restorative breast surgery.
Best of luck!
Dr. Schwartz
Board Certified Plastic Surgeon
Web reference: http://beverlyhillsbreastandbodyinstitute.com
Will My Lower Poles Fill Out?
ONY 3 weeks! Best to allow 3 to 6 moths of healing with constant downward pressure using strapping option. Appears as a very good early rest. Quokkas to Dr Hartog
You might also like...
Lower pole fullness
Since you are only 3 weeks massage is good plus wearing a velcro bra strap above your upper poles to puish the implants lower if this is what you want.
Web reference: http://beautybybrueck.com
Breast Augmentation - Post Op Swelling?
Thank you for your question and photos. You are still early in the post-operative period. It typically takes 3 - 6 months for the swelling to subside and and implants to settle into proper position. Please discuss your concerns with your board certified plastic surgeon. Also, make sure you follow all of your plastic surgeons post-operative instructions regarding level of physical activity and use of a support bra. Hope this helps and good luck with your recovery.
Web reference: http://www.rottmanplasticsurgery.com/before-after-breast-augmentation-baltimore/
Will My Lower Poles Fill Out After Breast Augmentation?
Although no one will replace your own plastic surgeon when it comes to accurate assessment, advice, and meaningful reassurance, I think that you are doing well at this point. I also think that you have a good understanding when it comes to additional time being "helpful" when it comes to breast implant movement. Best wishes for an outcome that you will be pleased with long-term.
Web reference: http://www.poustiplasticsurgery.com/Procedures/Procedure_breastAugmentation.htm
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Unable to sleep one night, I decided that a bit of nocturnal shopping might be novel. I tapped "Filson" - the Seattle-based company whose motto is: "Might as well have the best" - into my laptop (www.filson.com). I browsed the heavy-duty canvas luggage (right) before popping my order into the basket in the corner of the screen. I ordered a bag and, being of an impatient nature, asked for it to be sent express, by UPS.
Warming to my new on-line shopping experience, I also looked up LL Bean (www.llbean.com) and ordered a pair of blucher moccasins as a replacement for a pair that had served me well for more than 10 years. Then, I just held off from ordering some new Oxford shirts from Brooks Brothers (www.brooksbrothers.com).
The problem with this type of shopping is that it is so easy and it doesn't feel like you are spending any money. So finally, I went back to bed. A few days later, the man in brown duly delivered my Filson parcel, whereupon I realised that not only was the freight a hefty $90 (pounds 48) but that I was also required to pay a whopping amount in duty and government charges. And this in the bicentenary year of the Battle of Trafalgar. It seems that England still expects that every man will pay his duty.
Next week: Mr CoolReuse content


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- First Online:
- Cite this article as:
- Scott, L.J., Dunn, C.J., Mallarkey, G. et al. Drugs (2002) 62: 1503. doi:10.2165/00003495-200262100-00006
- Citations
- 208 Downloads
Esomeprazole (S-isomer of omeprazole), the first single optical isomer proton pump inhibitor, generally provides better acid control than current racemic proton pump inhibitors and has a favourable pharmacokinetic profile relative to omeprazole.
In a large well designed 8-week trial in patients (n >5000) with erosive oesophagitis, esomeprazole recipients achieved significantly higher rates of endoscopically confirmed healed oesophagitis than those receiving lansoprazole. Respective healed oesophagitis rates with once-daily esomeprazole 40mg or lansoprazole 30mg were 92.6 and 88.8%. Overall, esomeprazole was also better than omeprazole, although these differences were not always statistically significance. Ninety-two to 94% of esomeprazole recipients (40mg once daily) achieved healed oesophagitis versus 84 to 90% of omeprazole recipients (20mg once daily). Esomeprazole was effective across all baseline grades of oesophagitis; notably, relative to lansoprazole, as baseline severity of disease increased, the difference in rates of healed oesophagitis also increased in favour of esomeprazole. Resolution of heartburn was also significantly better with esomeprazole 40mg than with these racemic proton pump inhibitors. Long-term (up to 12 months) therapy with esomeprazole effectively maintained healing in these patients.
Once-daily esomeprazole 20 or 40mg for 4 weeks resolved symptoms in patients with symptomatic gastro-oesophageal reflux disease (GORD) without oesophagitis. Symptoms were effectively managed in the long-term with symptom-driven on-demand esomeprazole (20 or 40mg once daily).
Eradicating Helicobacter pylori infection is considered pivotal to successfully managing duodenal ulcer disease. Seven days' treatment (twice-daily esomeprazole 20mg plus amoxicillin 1g and clarithromycin 500mg) eradicated H. pylori in ≥86% of patients (intention-to-treat), a rate that was similar to equivalent omeprazole-based regimens.
Esomeprazole is generally well tolerated, both as monotherapy and in combination with antimicrobial agents, with a tolerability profile similar to that of other proton pump inhibitors. Few patients discontinued therapy because of treatment-emergent adverse events (<3% of patients), with very few (<1%) drug-related serious adverse events reported.
Conclusions: Esomeprazole is an effective, well tolerated treatment for managing GORD and for eradicating H. pylori infection in patients with duodenal ulcer disease. In 8-week double-blind trials, esomeprazole healed oesophagitis and resolved symptoms in patients with endoscopically confirmed erosive oesophagitis and overall, provided better efficacy than omeprazole. Notably, in a large (n >5000 patients) double-blind trial, esomeprazole 40mg provided significantly better efficacy than lansoprazole in terms of healing rates and resolution of symptoms. Long-term therapy with esomeprazole maintained healed oesophagitis in these patients. Esomeprazole also proved beneficial in patients with symptomatic GORD without oesophagitis. Thus, esomeprazole has emerged as an option for first-line therapy in the management of acid-related disorders.
Pharmacodynamic Properties
Esomeprazole inhibits the activity of the H+/K+-ATPase enzyme (the proton pump), and thereby reduces secretion of hydrochloric acid by gastric parietal cells.
Superiority of esomeprazole 40mg daily over omeprazole, lansoprazole, rabeprazole and pantoprazole in terms of elevation of intragastric pH has been shown in a number of randomised, crossover trials (most of which were nonblind) in healthy volunteers and patients with symptoms of gastro-oesophageal reflux disease (GORD). On the fifth day of treatment intragastric pH was >4 for a mean 59.4 to 69.8% of the monitored 24-hour periods in individuals receiving esomeprazole 40mg daily. These percentages were significantly greater than those with comparators (43.7 to 62% for esomeprazole 20mg, omeprazole 20 or 40mg, rabeprazole 20mg, pantoprazole 40mg, lansoprazole 30mg daily). Similarly, esomeprazole 20mg daily was superior to omeprazole 20mg or lansoprazole 15mg daily in the maintenance of intragastric pH >4. Higher percentages of patients receiving esomeprazole 20 or 40mg compared with recipients of other agents maintained intragastric pH >4 for periods ranging from at least 8 hours to more than 16 hours. In one nonblind study in 35 patients with GORD receiving esomeprazole 40mg or rabeprazole 20mg daily, pH was >4 for 23.2 and 11%, respectively, of the first 4 hours after administration of the first dose of study medication, indicating a more rapid onset of reduction of intragastric pH with esomeprazole.
Esomeprazole has no apparent effect on a variety of endocrine and metabolic functions, but the drug increases fasting serum gastrin levels in a dose-related fashion.
Pharmacokinetic Profile
Esomeprazole is absorbed rapidly after oral administration, with areas under the plasma concentration-time curves (AUCs) increasing in a nonlinear dose-related fashion after single doses. Systemic exposure to esomeprazole [as shown by mean AUC extrapolated to infinity (AUC∞)] increases with repeated administration of the drug (by 90% with 20mg daily and 159% with 40mg daily relative to day 1 after 5 day's treatment in healthy volunteers). This effect is attributed to reductions n total body clearance and first-pass metabolism with repeated doses. Binding to plasma proteins of esomeprazole (97%) is similar to that seen with omeprazole and other proton pump inhibitors.
Metabolism of esomeprazole is via hepatic cytochrome P450 (CYP) isoenzymes, chiefly CYP3A4 and CYP2C19, with approximately 80% of each dose being excreted as metabolites in the urine. A small proportion of the population lacks a functional form of the CYP2C19 isoenzyme and are therefore poor metabolisers of esomeprazole. AUC data indicate that dosage adjustments are not necessary in these individuals.
Comparative pharmacokinetic data obtained in patients with GORD show similar times to attainment of peak plasma concentrations with esomeprazole and omeprazole (approximately 1 hour). However, after 5 days' treatment, the geometric mean AUC∞ for esomeprazole 20mg was approximately two times higher than that for omeprazole 20mg daily, whereas that for esomeprazole 40mg daily was over five times higher than omeprazole 20mg (p < 0.0001 for both differences) in a study in 36 evaluable patients. There was also less interpatient variability in AUC∞ values with esomeprazole than with omeprazole, although statistical significance was not stated for this finding.
Systemic exposure to esomeprazole is not increased sufficiently to warrant tolerability concerns in patients with mild to moderate hepatic insufficiency; maximum plasma concentrations increased 28% in 12 patients with mild (Child-Pugh class A) to severe (Child-Pugh class C) hepatic insufficiency. There are no clinically significant gender effects on the drug's disposition. The potential for interactions between esomeprazole and other drugs is reported to be low and similar to that with omeprazole.
Clinical Efficacy
In patients with erosive GORD: In randomised, double-blind, multicentre trials of 8 weeks' duration (the usual duration of these trials), esomeprazole effectively healed oesophagitis (primary efficacy endpoint) and resolved heartburn (secondary endpoint) in patients with GORD. Patients received oral esomeprazole 20 or 40mg, lansoprazole 30mg or omeprazole 20mg once daily before breakfast. Patients who showed endoscopically confirmed healed oesophagitis were discontinued from studies at 4 weeks.
Overall, esomeprazole was better than omeprazole in terms of endoscopically confirmed healed oesophagitis and resolution of symptoms, although these differences favouring esomeprazole were not always statistically significant. Notably, in a large (n >5000 patients) well designed trial, significantly more recipients of esomeprazole 40mg once daily than lansoprazole 30mg once daily showed healed oesophagitis at 8 weeks (92.6 vs 88.8% of patients; p < 0.001). Similarly, 92 to 94% of esomeprazole (40mg once daily) recipients achieved healed oesophagitis at 8 weeks compared with 84 to 90% of those receiving omeprazole 20mg daily. Of these double-blind trials, one evaluated both esomeprazole 20mg and 40mg; a significantly higher percentage of patients achieved healed oesophagitis in both the esomeprazole 20 (89.9% of patients; p < 0.05 vs omeprazole) and 40mg (94.1%; p < 0.001 vs omeprazole) groups than in the omeprazole 20mg group (86.9%). Evidence-based analysis using pooled data from two trials confirmed that esomeprazole was more effective than omeprazole in healing erosive oesophagitis; 11 patients would need to be treated with esomeprazole 40mg once daily rather than omeprazole 20mg once daily to prevent one treatment failure.
The higher response rates with esomeprazole treatment relative to omeprazole occurred across all baseline grades of disease severity (based on Los Angeles Classification grades). Furthermore, relative to lansoprazole, as the baseline severity of disease increased, the difference in rates of healed oesophagitis also increased in favour of esomeprazole.
Esomeprazole also proved effective in patients with erosive oesophagitis according to secondary efficacy endpoints (e.g. percentage of heartburn-free days and nights, and the time to sustained resolution of symptoms). Heartburn resolution with esomeprazole 40mg was significantly better than that of omeprazole for all secondary efficacy endpoints, with a significantly reduced time to complete resolution of symptoms. Furthermore, esomeprazole recipients experienced significantly more nights without heartburn relative to lansoprazole, (87.1 vs 85.8% of nights heartburn-free; p ≤0.05), with complete resolution of symptoms occurring sooner in the esomeprazole group (7 vs 8 days; p ≤0.01); there was no between-group difference in the number of days without heartburn.
Resolution of symptoms matched healed oesophagitis rates in a post-hoc analysis of pooled data from 8-week randomised, double-blind trials evaluating 4877 patients. After 4 weeks' treatment with esomeprazole 40mg once daily, 83.4 and 81% of recipients who had healed oesophagitis were asymptomatic for heartburn and acid regurgitation, respectively, compared with 75.4 and 71.6% of those receiving omeprazole 20mg once daily (p < 0.001 for both comparisons).
Maintenance therapy in patients with GORD: Esomeprazole 20 or 40mg once daily was significantly more effective than placebo in maintaining healing, prolonging the time to recurrence of erosive oesophagitis in two 6-month randomised, double-blind, multicentre trials. Healed oesophagitis was maintained in 79 and 93% (esomeprazole 20mg), 88 and 94% (esomeprazole 40mg), or 29% (placebo) of patients. Subgroup analyses indicated that maintenance of healing with esomeprazole treatment was not influenced by gender, age (≥65 years vs <65 years of age), initial treatment during the healing phase, time to healing in this phase (4 vs 8 weeks) or baseline severity of erosive oesophagitis. Similar results were reported in a noncomparative trial of 12 months' duration.
Although there was no statistically significant difference in the percentage of patients who were heartburn-free at 6 months with esomeprazole and placebo treatment, this most likely reflects the fact that only patients with maintained healing remained in the study at 6 months.
A significantly higher percentage of esomeprazole (20mg once daily) than lansoprazole (15mg once daily) recipients remained in remission (primary end-point) at 6 months in a large, randomised, double-blind trial (83 vs 74% of patients; p < 0.001). Esomeprazole recipients showed higher rates of remission across all grades of baseline disease severity than lansoprazole-treated patients. Furthermore, significantly more esomeprazole than lansoprazole recipients were asymptomatic at 6 months [heartburn-free (78 vs 71% of patients), acid regurgitation-free (81 vs 72%) and epigastric pain-free (80 vs 75%)].
In patients with symptomatic GORD without oesophagitis: Esomeprazole 20 or 40mg once daily for 4 weeks effectively resolved symptoms in patients with symptomatic GORD without oesophagitis in two randomised double-blind trials. Thirty-three to 42% of patients achieved complete resolution of heartburn (no heartburn during the final 7 days of the 4-week studies) with esomeprazole versus 12 and 14% of placebo recipients. Additionally, 63 to 68% of days were heartburn-free with esomeprazole (20 or 40mg once daily) therapy compared with 36 and 46% with placebo. Respective median times to sustained resolution of heartburn were also significantly shorter in patients receiving esomeprazole (12.1 to 17.3 vs 20.8 and 22.3 days).
Symptom-driven on-demand therapy (esomeprazole 20 or 40mg once daily) was effective in the management of patients with symptomatic GORD without erosive oesophagitis in two 6-month randomised, double-blind, multicentre studies. Log-rank analysis indicated that the time to discontinuation because of unwillingness to continue therapy (primary endpoint) was appreciably longer in those receiving esomeprazole 20 or 40mg than in placebo recipients (p < 0.0001 all comparisons in both studies), with markedly fewer patients having discontinued treatment at study end in the esomeprazole than the placebo groups (8 to 15% vs 42 and 52% of patients). The vast majority of patients in both treatment groups who discontinued treatment did so because of inadequate control of heartburn.
Eradication of Helicobacter pylori infection: Seven to 10 days' treatment with triple therapy regimens that included esomeprazole (20mg twice daily or 40mg once daily) or omeprazole (20mg once daily), plus twice-daily amoxicillin 1g and clarithromycin 500mg, effectively eradicated H. pylori infection in patients with duodenal ulcer disease.
In over 400 patients with endoscopically confirmed duodenal ulcers, eradication of H. pylori occurred in 86 to 90% of recipients of triple therapy regimens including esomeprazole 20mg twice daily for 7 days in two randomised, double-blind, multicentre trials. These eradication rates were similar to those achieved with omeprazole-based triple therapy regimens (eradication rate of 88% in both studies; intention-to-treat analyses).
As expected, 10 days' treatment with triple therapy including esomeprazole 40mg once daily was significantly (p < 0.001) more effective in eradicating H. pylori infection than 10 days' dual therapy (esomeprazole plus clarithromycin at the same dosages) [77 vs 52% of patients; intention-to-treat analysis].
Currently, data evaluating the efficacy of esomeprazole-based triple therapy regimens on ulcer healing are limited. Nevertheless, in a well designed trial, triple therapy including esomeprazole (20mg twice daily for 1 week) followed by 3 weeks' treatment with placebo was as effective for ulcer healing as a similar twice-daily omeprazole-based triple therapy regimen followed by omeprazole 20mg once daily for 3 weeks (91 vs 92% of patients experienced ulcer healing; intention-to-treat analysis).
In general, recipients of esomeprazole-based triple therapy regimens showed an improvement in the frequency and severity of epigastric pain and heartburn from baseline levels in two double-blind trials. In the largest study, markedly fewer patients were experiencing epigastric pain (14 vs 96% of patients at baseline) and heartburn (10 vs 66%) after 4 weeks' treatment (1 week of esomeprazole-based triple therapy, followed by 3 weeks of placebo) than at baseline. Similar symptomatic improvements from baseline were also experienced in those receiving omeprazole-based triple therapy for 1 week followed by omeprazole 20mg once daily for 3 weeks (epigastric pain experienced by 95% of patients at baseline vs 15% at 4 weeks; heartburn by 68 vs 5%). These improvements were maintained in both treatment groups at 8 to 10 weeks' follow-up.
Pharmacoeconomic considerations: Pharmacoeconomic studies of esomeprazole are currently limited to preliminary cost analyses based on clinical trial results and/or patient databases.
A decision-analysis model based on pooled data from three 8-week clinical studies in 4877 patients with endoscopically confirmed reflux oesophagitis showed a 14% reduction in direct medical costs with esomeprazole 40mg over omeprazole 20mg daily. The cost saving of £1290 over 8 weeks was increased to £2064 when treatment failure costs were accounted for. Direct medical costs for primary care visits, gastroenterologists visits and upper gastrointestinal endoscopy were based on 1998 UK values, and those for the acquistion of drugs on 2000 values. A further decision-analysis model has shown an apparent saving relative to omeprazole 20mg daily in direct medical costs from a UK National Health Service perspective when esomeprazole 40mg daily is given to patients with a diagnosis of GORD without endoscopic confirmation.
Application of results from two 6-month studies in 770 patients receiving on-demand treatment of GORD with esomeprazole 20mg daily or placebo to a Markov model showed reductions in direct medical costs with esomeprazole of 16 and 35%, respectively, relative to intermittent acute 4-week treatment or continuous therapy with omeprazole 20mg daily. UK direct medical costs for primary care visits, gastroenterologists visits and upper gastrointestinal endoscopy were based on 1998 values, and those for the acquistion of drugs on 2000 values. In addition, an annual cost advantage for esomeprazole 20mg daily over omeprazole 10 or 20mg daily has been shown on the basis of UK drug costs, clinical trial data and drug usage statistics derived from a 1028-patient UK general practice database.
Like other proton pump inhibitors, esomeprazole is well tolerated as reported in both clinical trials and in pooled tolerability data (n = 6682). In two large 8-week randomised trials (n = 2405 and 1957), a similar proportion of patients (≈1 to 2.6%) receiving esomeprazole 20 or 40mg once daily or omeprazole 20mg once daily discontinued treatment due to an adverse event. There was no difference in the nature or frequency of individual adverse events (1.8 to 8.7% of patients) in these trials; headache, diarrhoea, nausea, abdominal pain and respiratory infection were most commonly reported. No treatment-related serious adverse events were reported with esomeprazole or omeprazole therapy in these studies. There were also no clinically relevant changes in laboratory parameters or vital signs with either treatment.
There were no between-group differences in the tolerability profiles of esomeprazole 40mg once daily or lansoprazole 30mg once daily in a large randomised, double-blind trial in >5000 patients with erosive oesophagitis. Ten percent of patients in each treatment group experienced at least one adverse event considered to be drug-related; the most frequently reported adverse events with either esomeprazole or lansoprazole treatment were headache (5.8 vs 4.5%), diarrhoea (4.2 vs 4.7%), respiratory infection (2.8 vs 3.8%), abdominal pain (2.9 vs 2.9%), flatulence (2.3 vs 2.4%) and nausea (2.1 vs 2.5%). Serious adverse events considered to be treatment related occurred in 0.7 and 0.5% of patients in the esomeprazole and lansoprazole groups, respectively, with 1.8 and 1.9% of recipients discontinuing treatment due to adverse events. There were no clinically relevant changes in laboratory parameters or vital signs in either treatment group.
Triple therapy with esomeprazole plus amoxicillin and clarithromycin for 7 or 10 days for the eradication of H. pylori infection was most commonly associated with diarrhoea, taste perversion and abdominal pain according to pooled tolerability data (number of patients not reported). The esomeprazole triple therapy regimen was associated with a similar tolerability profile to that of an equivalent omeprazole-based regimen.
Maintenance therapy with esomeprazole 20 or 40mg once daily for 6 months was generally well tolerated in patients with healed GORD in two randomised, double-blind trials in 318 and 375 patients. The nature of drug-related adverse events experienced with maintenance treatment was no different from that experienced with 4 to 8 weeks' treatment. A 12-month noncomparative study in 807 patients with healed oesophagitis confirmed that esomeprazole 40mg once daily was well tolerated.
Patients who received esomeprazole as maintenance therapy remained in randomised studies for a much longer time than placebo recipients (mean values: 116 to 161 vs 59 and 61.5 days). Therefore, direct comparisons of adverse event ncidences were difficult to make. After 1 month of treatment, the incidences of the most common adverse events and the proportions of patients who experienced at least one adverse event were similar in the esomeprazole and placebo groups. Over the 6 months' duration of these trials, esomeprazole was generally associated with higher rates of discontinuation due to adverse events and higher overall frequencies of adverse events than placebo, possibly because of the longer treatment time with the active drug.
Considerably more patients receiving esomeprazole 20mg as required (up to 20 mg/day) than placebo recipients completed a study of symptom-driven on-demand maintenance therapy in patients without erosive oesophagitis. More esomeprazole than placebo recipients experienced adverse events; however, the frequency of events was similar in the two treatment groups when adjusted for exposure to treatment. Respiratory infection was the most common event in both treatment groups.
No enterochromaffin-like cell dysplasia, carcinoids or neoplasia were reported in pooled tolerability data from noncomparative and randomised studies in 1326 patients with healed erosive oesophagitis who received esomeprazole 10, 20 or 40 mg/day or placebo for up to 6 or 12 months. Gastric histological scores with both esomeprazole and placebo fluctuated to a minor extent and there were no concerns relating to development of atrophic gastritis or clinically significant changes in enterochromaffin-like cells.
Dosage and Administration
Dosage recommendations for esomeprazole differ between countries. In the UK, esomeprazole 40mg once daily for 4 to 8 weeks is indicated for the healing of erosive oesophagitis associated with GORD, with a further 4 to 8 weeks at the same dosage considered if oesophagitis is not healed; the recommended dosage in the US is 20 or 40mg once daily for 4 to 8 weeks, with a further 4 to 8 weeks' treatment considered if oesophagitis is not healed. Esomeprazole 20mg once daily is recommended in both countries for the maintenance of healed erosive oesophagitis. Currently, no controlled studies of >6 months' duration have been carried out; a noncomparative trial of 12 months' duration has been conducted. In patients with symptomatic GORD, esomeprazole 20mg once daily for 4 weeks is recommended in both countries. In the UK, subsequent symptom control can be achieved using an 'on-demand' regimen of 20mg once daily as required.
For the eradication of H. pylori in patients with duodenal ulcer disease, triple therapy with esomeprazole 20mg twice daily plus twice-daily amoxicillin 1g and clarithromycin 500mg for 7 days is recommended in the UK, whereas in the US triple therapy consists of esomeprazole 40mg once daily plus amoxicillin 1g twice daily and clarithromycin 500mg twice daily for 10 days.
Esomeprazole dispersable tablets (multiple unit pellet system) should be swallowed whole at least one hour before eating; the pellets may be mixed with apple sauce for patients who have difficulty in swallowing. In nursing mothers, a decision should be made whether to discontinue nursing or to discontinue treatment. Although animal studies have shown no evidence of fetal abnormality, there are no well controlled trials in pregnant women (category B rating); thus, the drug should be used during pregnancy only if clearly needed. Dosage adjustments are not necessary in patients who are elderly or those with renal or mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dosage of esomeprazole should not exceed 20 mg/day. The tolerability and effectiveness of esomeprazole have not been established in paediatric patients.
Concurrent administration of esomeprazole with warfarin, quinidine, clarithromycin or amoxicillin does not produce any clinically significant interactions. Esomeprazole may, however, interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g. ketoconazole, itraconazole, digoxin and iron salts). Plasma concentrations of phenytoin should be monitored when initiating or discontinuing coadministration of esomeprazole.


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Sir: Being a young member of the Charismatic Movement, I must make a defence. The Rev Bown (Letters, 25 August) tells mainstream churches to ward against such people as me, because I am in a situation where I can suffer profound psychological and spiritual damage. However, I think that John Wesley, who professed to have been "strangely warmed" in his heart by the Holy Spirit, would have been flattered by the title "charismatic".
Emotion in our services is also criticised. Why is it that when a tragic play produces tears, a comedy laughter, a football match excitement, they are labelled "good", yet when a congregation is moved by the glory of God, it is called "unhealthy".
In expecting miracles, we follow Jesus' example, who obviously advocated "quick-fix" religion. Being addicted to Jesus is no bad thing - the Psalmist tells us to delight in Him, and the Bible tells us to be filled with the Spirit.
If you see a blind dog, do you presume that all dogs are blind? Neither can you call the Charismatic Movement all bad because of one incident.
Yours faithfully,
Andrew Thomas
(Student, aged 17)
Umberleigh, DevonReuse content


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Despite the versatility of a scrambler-style bike, there are very few factory-built scramblers on the market but soon there will be another. This week at the Intermoto expo in Cologne, Ducati unveils its new 803-cc Scrambler in 4 different trims, ranging from the 70s-inspired Classic edition to the dirt-craving Urban Enduro edition. Starting at $8595, the new Scrambler is the lowest priced bike in the Ducati lineup.
Roland Sands Design took a sparkling new 2014 Indian Chieftain and completely desconstructed the 800 pound beast to create a nimble 1930s race-inspired board tracker. This meant building everything but the engine from scratch: a new frame with a single-sided rigid rear-end, new hand-built titanium exhaust, gas tank, & springer front-end, electrical overhaul, etc.
If you want a one-off custom Harley, here's another compelling reason to choose Taiwan-based Rough Crafts for your build. What was once a stock Dyna Street Bob is now called Urban Cavalry. On top of loads of performance mods, the RC crew gave this bike a new front-end, a handmade tail section, a titanium 2-into-1 exhaust and more. via
The Hellcat Speedster looks more like a normal motorcycle than any bike Confederate Motorcycles has ever made. But it's definitely a cut above. Surrounding its 2163cc V-twin powerplant is a sculptural mix of billet aluminum and carbon fiber. Each bike is handmade to order in limited numbers in Alabama, USA.
Aside from the engine, which comes from a Honda 125 SuperSport, nearly every piece of this new bike from Bandit9 is handmade. The metallic unibody is made from a single block of aluminum & for the creation of the high-gloss, waterproof, burl wood side panels, the Bandit9 boys recruited a guitar luthier & a yacht maker. It's all bespoke, from the suede seat to the alloy exhaust and only 9 of these little city-street rippers will be made.
The newest Polaris-built Indian is The Scout, a model that hadn't been revamped since it was dubbed "the world's fastest Indian" back in 1967. Unveiled this week at Sturgis, the man-sized classic cruiser weighs in at a hefty 562-pounds, powered by a 1133cc V-twin that churns out 100 horsepower.
Inside a motorcycle helmet seems like maybe the best place yet for a heads-up display. The Skully AR-1 is it, the world's 1st HUD-enabled helmet. A 180º camera eliminates blindspots, it also features internet, phone, & music capabilities via voice-command, a push button tinted view activation & stacks of other features. Currently seeking beta testers.
Through a partnership with Honda, Britain's foremost custom track car maker Ariel builds bikes like the Ace one-at-a-time to individual customer specs. Powered by a Honda 1237cc V4 and based around their trellis frame, your Ace can be built up in any way you like, as long as what you want is the highest quality components.
Harley-Davidson is putting the company's first electric motorcycle on the road; the LiveWire is a sport bike that looks like nothing HD has ever made before. It does 0-60 sub 4 and makes a sound like a jet turbine. A fleet of LiveWire demo bikes is currently touring the country allowing riders to test them out while HD gauges interest before putting them into production.
It looks a lot like its big brother, the 1200S, but Ducati's newest Monster is a bit smaller; powered by a more compact water-cooled, 821-CC Testastretta 11° V-twin. It also got 8-level traction control & ABS from its big bro and will be offered 2 models: the regular 821 in red & white & the blacked-out 821 Dark.


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ALAN PARDEW was left gobsmacked by Chelsea's decision to sack Roberto Di
Blues parted company with the Italian this morning despite winning the
Champions League and FA Cup during his short tenure.
And Newcastle boss Pards reckons RDM's exit underlines how no manager in the
Premier League can take their position for granted.
He said: "I'm astonished, really.
"It just goes to show you how precarious we are as Premier League managers —
and you can't take anything for granted.
"The shock that should be there for the fans and the media should sound
something to the owner of that football club because I don't know if that's
the ninth manager or whatever it is in so many short years. It's just not
"As far as I am concerned, he has done absolutely nothing wrong.
"His philosophy was to perhaps change the look of the team, which he has
tried to do — that doesn't happen overnight — and he's won two competitions
in less than a year, so it's unbelievable.
"He should walk straight into another job — probably at someone else's
misfortune, unfortunately."
In stark contrast to the managerial merry-go-round at Stamford Bridge, Pardew
was handed a mammoth eight-year deal at Toon earlier this season.
Pards' shock echoes that of Manchester United defender Rio Ferdinand, who
described Roman Abramovich's axe wielding as "madness".
Benitez and Pep Guardiola are two of the names in the frame to succeed Di
Meanwhile, Pardew insists Magpies owner Mike Ashley is well aware of the
strains European football is placing on his injury-hit squad.
The Toon have seen their Premier League form suffer as the rigours of the
Europa League take their toll, having signed just one senior player in the
summer Dutch midfielder Vurnon Anita.
Pards said: "We are all concerned. It's not like it's just heaped on myself
and 'Get on with it'.
"The managing director and the owner are very conscious of where we are and we
are trying to make sure that we look at the period and events leading up to
the next window, and we will react from there."


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Lauren Cohan Credits
Lauren Cohan Movies
All Eyez on Me
- June 16th, 2017
Tupac centers on the life of the charismatic yet controversial artist. Rapper, poet, actor and political activist, Tupac shot to fame with 2Pacalypse Now, lauded for its seminal underground vibe and still an inspiration for major artists today. Tupac's politically charged lyrics, inspired by his parents' activism as Black Panthers in the 60s & early 70s, condemned governmental intrusion in black communities. Tupac's increased participation in the East Coast-West Coast Rap rivalry became well documented and avidly followed by his fans. On September 7, 1996 he was gunned down on a street corner in Las Vegas, where he died 6 days later. His murder was never solved.
Young Alexander the Great
- December 1st, 2010
- 90 mins
The coming of age of young Alexander, future world conqueror, from his boyhood in Greece to his assumption of Regent of the Land, after proving his worth to his father, the demanding King Phillip.
The Boy
- January 22nd, 2016
- 98 mins
- 27%
Greta is a young American woman who takes a job as a nanny in a remote English village, only to discover that the family's 8-year-old is a life-sized doll that the parents care for just like a real boy, as a way to cope with the death of their actual son 20 years prior. After violating a list of strict rules, a series of disturbing and inexplicable events bring Greta's worst nightmare to life, leading her to believe that the doll is actually alive.
Batman v Superman: Dawn of Justice
- March 25th, 2016
- 151 mins
- 27%
Fearing the actions of a god-like superhero left unchecked, Gotham City's own formidable, forceful vigilante takes on Metropolis's most revered, modern-day savior, while the world wrestles with what sort of hero it really needs. And with Batman vs Superman at war with one another, a new threat quickly arises, putting mankind in greater danger than it's ever known before.
Death Race 2
- January 18th, 2011
- 110 mins
In the world's most dangerous prison, a new game is born: Death Race. The rules of this adrenaline-fueled blood sport are simple, drive — or die. When repentant convict Carl Lucas (Luke Goss) discovers there's a price on his head, his only hope is to survive a twisted race against an army of hardened criminals and tricked-out cars. Also starring Danny Trejo and Ving Rhames, Death Race 2 tells the explosive story of how the legendary race began. Strap yourself in for an insane thrill-ride!
Reach Me
- November 21st, 2014
- 95 mins
A motivational book written by a mysterious man (Tom Berenger) goes viral and quickly gains popularity, inspiring a group of people to re-evaluate their choices by confronting their fears in hopes of creating more positive lives.
Law & Order: Special Victims Unit
- 1999
- 60 mins
This show delves into the dark side of the New York underworld as the detectives of a new elite force, the Special Victims Unit, investigate and prosecute various sexually oriented crimes, while trying to balance the effects of the investigation on their own lives.
- Written by
Brian Barjenbruch
National Lampoon's Van Wilder: The Rise of Taj
- December 1st, 2006
- 97 mins
"Van Wilder Deux: The Rise of Taj" is the sequel to the successful 2002 release, National Lampoon's "Van Wilder." Taj (Kal Penn) from the first film, heads to England's prestigious Oxford University to further his studies while in the process, showing the uptight student body how to party.
- December 25th, 2005
- 112 mins
- 43%
He was the world's most notorious seducer. A swashbuckler, master of disguise and wit - it was said no woman could resist Casanova's amorous charms. Until now.
Lauren Cohan TV Shows
The Mindy Project
The Mindy Project is a new single-camera comedy from Emmy Award-nominated writer/producer and New York Times best-selling author Mindy Kaling ("The Office") that follows a woman who, despite having a successful career, desperately needs to break bad habits in her personal life. After all, how many doctors make inappropriate toasts at their ex-boyfriend's wedding, nearly drown at the bottom of a stranger's pool and get arrested for disorderly conduct just moments before having to deliver a baby? Funny, impatient and politically incorrect, Mindy Lahiri (Kaling) can quote every romantic comedy starring Meg Ryan that exists. She loves the good ones and the bad ones, because the girl always gets the guy. Mindy is determined to be more punctual, spend less money, lose weight and read more books – all in pursuit of becoming a well-rounded perfect woman…who can meet and date the perfect guy. Mindy is a skilled OB/GYN and shares a practice with a few other doctors, none of whom make life any easier for her. Jeremy Reed (British writer/comedian Ed Weeks) is the walking definition of total bad news. He not only shares a practice with Mindy, but sometimes her bed as well – despite her best efforts to resist. He is funny, self-absorbed and super sexy. In contrast, Danny Castellano (Chris Messina, "Damages") is a hothead and guys' guy who has a habit of stealing Mindy's patients. Danny criticizes her for everything, including her struggling love life and her lack of professionalism – even though it's obvious to everyone except Mindy that he secretly admires her work. His blue-collar childhood gives him a big chip on his shoulder, but he is a dedicated physician, which Mindy can't stand to admit because he's always getting on her case. Rounding out the office staff are the receptionists – Betsy Putch (Zoe Jarman, "Huge"), young, earnest and easily excitable, who thinks the world of Mindy and is always trying to impress her; and Shauna Dicanio (newcomer Dana DeLorenzo), a self-assured Jersey Girl who is indifferent to Mindy, always knows where the cool party is and carries a poorly concealed torch for Danny. Mindy is in constant communication with her beloved best friend from college, Gwen Grandy (Anna Camp, "The Good Wife"), who also happens to be the governor's daughter. Gwen is a hilarious, sometimes too-blunt friend, and secretly a former carefree party girl (which only Mindy seems to remember). Although Gwen is now happily married to a financial analyst, with a six-year-old daughter, this lawyer-turned-Pilates mom remains squarely in Mindy's corner. As Mindy attempts to get her career off the ground and meet a guy who passes her red flag test (no drug habits, no skinny jeans and no secret families, among others), only time will tell if she gets her romantic comedy ending.
The Vampire Diaries
The Vampire Diaries is based on a novel series penned by L.J. Smith about two vampire brothers - one evil and one good -who vie for the soul of Elena Gilbert, a young woman, her friends and her family.
The show is being produced by Alloy Entertainment in association with Warner Bros. Television.
Twenty-three years ago, Sam Winchester (Jared Padalecki) and Dean Winchester (Jensen Ackles) lost their mother to a mysterious and demonic supernatural force. Subsequently, their father John (Jeffrey Dean Morgan, "Grey's Anatomy") raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America...and he taught them how to kill it.
Cold Case
Cold Case stars Kathryn Morris (Minority Report, Mindhunters) as Lilly Rush, the lone female detective in the Philadelphia homicide squad who finds her calling when she's assigned to "cold cases" -- crimes that have never been solved.
Childrens' Hospital
This hospital drama set in a hospital for children airs on thewb.com.
From executive producer, Josh Schwartz and executive producer-director McG comes a one-hour, action-comedy series about Chuck Bartowski -- a computer geek who is catapulted into a new career as the government's most vital secret agent.
The Walking Dead
The six-episode first season — written, produced and directed by three-time Academy Award-nominee Frank Darabont (The Shawshank Redemption, The Green Mile) and executive produced by Gale Anne Hurd (The Terminator, Aliens, Armageddon, The Incredible Hulk) — follows a group of survivors, led by police officer Rick Grimes, traveling in search of a safe and secure home after a zombie apocalypse.
The third edition of the "CSI" franchise sets up shop in the Big Apple, where taciturn Detective Mac Taylor (Gary Sinise) and his partner, Detective Stella Bonasera (Melina Kanakaredes), lead a crime-solving team. Like his counterparts in Las Vegas and Miami, Taylor knows that people may lie, but the evidence rarely does. In the city that never sleeps, CSI: NY never rests.
FX steps into the animation arena with this comedy series about an international spy agency called ISIS.
Whose Line Is It Anyway?
Hosted by comedian Aisha Tyler, WHOSE LINE IS IT ANYWAY? features the return of cast members Ryan Stiles, Wayne Brady and Colin Mochrie, who helped make the original U.S. version of this comedy improve series such a hit. Along with a special guest comedian in each episode, the cast members must put their comedic skills to the test through a series of spontaneous improv games.
Prompted only by random ideas supplied by the studio audience and host Aisha Tyler, our four performers must use the little information they have and their wild imaginations to depict different characters and an array of scenes, as well as perform songs. After each round of improvisation, Aisha will dole out points to our four performers and declare a winner at the end of every episode.
Based on the wildly successful U.K. format, which also spawned a previous incarnation in the US that ran for eight seasons on ABC, WHOSE LINE IS IT ANYWAY? is executive produced by Dan Patterson, Mark Leveson, Jimmy Mulville, Ryan Stiles and Wayne Brady. Co-created by Dan Patterson and Mark Leveson, "Whose Line Is It Anyway?" is from Angst Productions and Hat Trick Productions.
Greek deities Aphrodite and her son Eros have settled here on Earth and are in the matchmaking business in this romantic dramedy from The CW.
Modern Family
This mockumentary explores the many different types of a modern family through the stories of a gay couple, a straight couple, and a multi-ethnic couple. These three types of families are being taped by a Dutch documentary crew who are using them for an upcoming reality-based television series due to air in The Netherlands.
Law & Order: Special Victims Unit
"In the criminal justice system, sexually-based offenses are considered especially heinous. In New York City, the dedicated detectives who investigate these vicious felonies are members of an elite squad known as the Special Victims Unit. These are their stories."
The Chew
The Chew will focus on food from every regard - as a source of health, happiness, family, friendship, fitness, romance, weight loss, travel and adventure. Viewers will get the dish on anything everything related to food. It will focus on new food trends, pesticides in food and urban gardens. Hosts include Mario Batali, Carla Hall, Clinton Kelly, Michael Symon and Daphne Oz.
Damien Lewis stars as a former police officer who, after years of false imprisonment, returns to the force with a decidedly different philosophy. Deadwood's Robin Weigert has been added to the cast of the series. She'll play the boss of Lewis' character, Lt. Davis. Brooke Langton will play the lawyer who got him out of prison that despite the fact that she is married, has a spark with Lewis.
Talking Dead
A live after show about The Walking Dead. Hosted by Chris Hardwick. Talking Dead features Hardwick spending time with fans, actors, producers and tv enthusiasts, recapping that most recent Dead episode, and taking questions and comments from viewers.


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Neko Case: The Tigers Have Spoken 12" (new)
Anti- Records
The Tigers Have Spoken is a 2004 live album by Neko Case. The album was recorded at several live shows inChicago and Toronto in the spring of 2004. Neko's backing band featured The Sadies and Jon Rauhouse. Guest performers included Carolyn Mark, Kelly Hogan, Jim & Jennie and the Pinetops, Paul Morstad and Brian Connelly.[2] The album was produced by Case and Darryl Neudorf.Tags: 00's 65804 indie melodic yoobl


text: Posted by Bob Condotta http://seattletimes.nwsource.com/ht...015523936_uws_five_most_indispensable_pl.html I'm never averse to, well, ripping off a good idea for a blog post --- especially in July. So I figured I'd do my own take on a series that ESPN.com is currently running, naming what it views as the Most Indispensable Players for each college football team. Simply put, it means the players the team can least ill afford to lose for any significant period of time. But instead of naming just one, I'll go them a little better and name the five Most Indispensable Players on the UW roster for 2011, in ascending order.


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Frequently asked questions
Development and re-development projects in the Northeast Ohio Regional Sewer District service area are subject to review and require District approval prior to beginning construction. Depending on the nature of the project, one or more types of review may be required. These include:
To determine if a project is subject to Northeast Ohio Regional Sewer District review, submit your project information form to: email@example.com.
To request plans for NEORSD infrastructure in your project area or to arrange for conflict review and resolution, please submit your project information form to: email@example.com.
In order to receive a determination letter to satisfy requirements of the Cleveland Planning Commission, email email@example.com or contact the Permit Program Manager at 216-881-6600 extension 6466. The information required include project location, disturbed area, and applicant contact information.


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The Arcadia Motor Inn is in the delightful town of Corowa, the birthplace of federation, and is an ideal getaway for a holiday or a short weekend break sitting on the banks of the mighty Murray River.
We are situated just minutes from the world acclaimed Rutherglen winery region ...
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