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Propagating semantic information in biochemical network models
Networks analysis
To enable automatic searches, alignments, and model combination, the elements of systems biology models need to be compared and matched across models. Elements can be identified by machine-readable biological annotations, but assigning such annotations and matching non-annotated elements is tedious work and calls for automation.
A new method called "semantic propagation" allows the comparison of model elements based not only on their own annotations, but also on annotations of surrounding elements in the network. One may either propagate feature vectors, describing the annotations of individual elements, or quantitative similarities between elements from different models. Based on semantic propagation, we align partially annotated models and find annotations for non-annotated model elements.
Semantic propagation and model alignment are included in the open-source library semanticSBML, available on sourceforge. Online services for model alignment and for annotation prediction can be used at
Systems biologists aim to understand the dynamic behaviour of cellular pathways with the help of quantitative models. To construct large-scale models flexibly from existing parts, models need to be retrieved, compared, and combined. For this purpose, modellers need to find and match equivalent model elements, for instance, variables describing identical metabolites. In the future, such alignments should be automated or, at least, sensible suggestions should be provided by software.
A simple way to match model elements is by comparing their names or identifiers as they appear in the model's code. Greedy alignments and model combination based on element names have been used in
Obviously, such comparisons will fail if annotations are missing. However, there are also algorithms that compare biological networks by their structures and can therefore handle missing annotations. Since the comparison of graph structures is computationally hard
In this article, we propose new heuristics for aligning network models with missing annotations. The basic idea is simple: a reaction, for instance in an SBML model, refers to its substrates and products. If two reactions are not annotated but their reactants are, we can trace the reactants, evaluate their annotations, and use this information for comparing the reactions. This logic can be applied whenever model elements show cross-references. Instead of collecting and combining this information step by step for each element, we developed a method to propagate all semantic information simultaneously across the network. Starting from an original
Two applications of semantic propagation are presented in this article. The first one is the improved alignment of systems biology models. The second one is a method for predicting missing annotations in a model by aligning it to fully annotated network models. Our present implementation, which is a part of the tool semanticSBML
We have developed methods for aligning partially annotated biological networks and implemented them for SBML models with MIRIAM-compliant annotations. A model alignment is based on two kinds of knowledge: similarities between model elements, which are computed from semantic annotations, and references between elements within each model (called here the "network structure").
The alignment of two models is computed in two steps. In a first step, semantic information is propagated across both network structures. This ensures that all elements, even elements lacking annotations, obtain semantic information, which makes them comparable between models. This claim of improved comparability is illustrated with an example of a propagation of "colour information" shown in Figure
Figure 1
Propagation of colour features
Propagation of colour features. Feature propagation in a small example network (circles: compounds; squares: reactions). A: Network nodes carry feature vectors
In the second step, the actual model alignment, elements are matched between two or more models according to their inferred similarities. We use a greedy heuristic that arranges similar elements into tuples, supposed to be matched: all elements in a tuple have the same type (e.g. reaction), stem from different models, and each element is part of one tuple (possibly of size 1). Elements within a tuple have to show a high similarity, while elements in different tuples are supposed to be dissimilar.
Feature propagation
The semantic propagation can be carried out in two ways, as feature propagation (FP) or as similarity propagation (SP). For feature propagation, each element has to be associated with a feature vector. The components of this vector (usually numbers between 0 and 1) describe how closely the element resembles certain biological concepts. A model species describing a phosphorylated MAP kinase, for example, could carry annotations referring to UniProt entry P28482 (MAPK1) and KEGG Compound entry C00562 (Phosphoprotein). The feature vector corresponding to this species would contain mostly zeros except for the two entries specifying the relation to these web resource entries. Two elements are similar if their feature vectors point to similar directions, i.e. if they are related to similar biological concepts like a phosphorylated and a non-phosphorylated MAP kinase. The size of the feature vector depends on the number of biological concepts considered, e.g. the entries of all web resources being referred to in BioModels Database
In feature propagation elements inherit semantic information from their neighbour nodes, which might contribute to the definition of the elements' identity. The inferred feature vectors do therefore not only characterise the model element itself, but also its surrounding elements in the network. In the case of a reaction element, they do not only describe the reaction, but also its reactants, enzyme, or regulators. The transition from the original to the inferred feature vectors is shown by an abstract example in Figure
Similarity propagation
The second approach, similarity propagation, is computationally harder, but also applies to similarity measures that are not based on feature vectors. In contrast to FP, we do not consider single model elements, but pairs of elements from different models to be compared, e.g. the reactions
Figure 2
Similarity propagation
Similarity propagation. A: Alignment of two models describing the same biochemical reaction (circles: compounds; squares: reactions). The reactants a and p have a known similarity
Additional file 1
Appendix. Text document containing details on the implementation, a further comparison of the methods, an additional numerical example, and further analyses.
Click here for file
Annotation prediction
Model alignments can be used to complete missing annotations in a model. To do so, one may align the model to a large, annotated map of all physiological pathways and copy annotations from elements in the map to the model elements they have been aligned to. Even if not all of these annotations are correct, they may still be presented to users as suggestions during manual model annotation.
Our semanticSBML web page for model annotation (
Self-alignment of a linear chain
To illustrate how semantic propagation can improve model alignment, let us consider a linear metabolic pathway in which only the first and the last species are annotated (see Figure
Figure 3
Alignments of computational models
Alignments of computational models. A: Linear pathway; only the first and the last species are annotated. B: Self-alignment of the linear pathway. Depicted are the pairwise element similarities according to the three different similarity measures. Each table entry contains six numerical values. The entries in the upper line denote the direct similarity
Alignment between MAP kinase pathways
As a real-world example, we aligned two well-annotated signal transduction models, model 9
Figure 4
Alignment of MAP kinase cascades
Alignment of MAP kinase cascades. Alignment of BioModels 9
In practice, models are often less carefully annotated than these example models and the quality of a model alignment will depend on the fraction of annotated elements. To study this in detail, we considered the same two models, removed some of the annotations in BioModel 9 randomly, aligned the models, and scored the quality of the alignments by precision and recall with respect to a manually chosen alignment. This procedure was repeated 25 times for each number of removed annotations. Figure
Figure 5
Assessing the quality of model alignments
Assessing the quality of model alignments. The quality of model alignments increases with the fraction of annotated model elements. Alignments between BioModel 9 and BioModel 11 (see Figure 4) were compared to a manually chosen, correct alignment and scored by their recall (left boxes) and precision (right boxes). When annotations are randomly removed, recall and precision (y-axis) decrease with the fraction of removed annotations (x-axis). Boxes in different rows show results from alignments with direct similarities, FP similarities, and SP similarities, as well as a comparison of their three mean values. The straight lines in the three topmost boxes show trends and stem from a linear regression.
Despite the indifference of the results with respect to the models which are compared, the quality of the results varied in between examples in which only species or reaction annotations had been removed. The more detailed the annotations in a specific subset of model elements was, the more dramatic the decline in matching quality has been after their removal. For a deeper analysis of the matching quality after the removal of either species or reaction annotations from BioModel 9, the reader is referred to additional file
Automatic suggestion of element annotations
In order to test the quality of our annotation prediction heuristic, we applied it to BioModel 61, a well-studied model of glycolysis
To study this systematically, we randomly removed annotations from some of the elements, predicted new annotations for them, and checked if the correct annotation appeared in the top results. As shown in Figure
Figure 6
Evaluation of the annotation prediction in BioModel 61
Evaluation of the annotation prediction in BioModel 61. Probability to find a correct annotation within in the first
We have implemented both propagation methods in Python. The source code of this implementation is included in our library semanticSBML, which is freely available (GPL 3) from SourceForge (
Furthermore, we have included the semantic propagation methods into our web tool semanticSBML
Annotating the elements of systems biology models is laborious. Interactive software can facilitate this work by keyword searches and by proposing annotations based on element names. Our software semanticSBML
As the examples have shown, element matchings based on our inferred similarity measures perform well in practice. In our tests, semantic propagation increased the recall of correct element pairs, but at the price of a lower precision if less than half of the elements were annotated. Our two approaches, feature and similarity propagation, differ slightly in their quality, but also in their computational costs. While similarity propagation tends to yield better results, the computational effort is much higher than in feature propagation
We furthermore showed how new annotations for model elements can be suggested based on the annotations already present in a model and an annotated pathway map. For our predictions, we have selected the BioModels Database as a resource for highly curated annotation data. Analyses using other resources (see additional file
The details on how information is transfered during semantic propagation depends on the choice of propagation weights. In our tests, changing their values within reasonable ranges had little influence on the model alignment. In any case, the scaling factor
Compared to existing approaches, our methods for model alignment have three advantages. First, by processing semantic annotations instead of
Semantic similarity
The biological meaning of a model element can be described with the help of annotations, which point to entries in different web resources. Since different web resources overlap in their content (e.g. ChEBI
Propagation of semantic information
To compare non-annotated model elements by their biological meaning (e.g. the reactions in Figure
Feature propagation applies to all similarity scores that are computed from feature vectors. For each
After choosing a scaling factor
The series expansion shows that the inferred feature vectors can be obtained by summing up a number of terms, describing how the direct features are propagated step by step through the network, e.g. from compartments to molecular species, from reactants to reactions, and so on. If information is propagated only in one direction on an acyclic graph, these contributions can be computed successively and the infinite series contains only a finite number of non-zero terms. Moreover, the series expansion shows that the inferred feature vectors are non-negative as long as the direct feature vectors and the propagation weights are nonnegative. By collecting the vectors v
In analogy to Eq. (1), the element similarity with inferred features reads
Similarity propagation
Our second scheme, similarity propagation (SP), works for any similarity score. Given the direct similarities
The idea is analogous to Eq. (2): the inferred similarity
Like in Eq. (4), if
Analogy to diffusion processes
Feature propagation resembles a diffusion process on the reaction network. Unlike diffusion in the strict sense, our process is not symmetric and does not conserve mass. Methods with a similar background idea have already been successfully applied to assign protein functions in protein-protein interaction networks
Likewise, similarity propagation can be seen as a diffusion-like process on a
Figure 7
Similarity propagation resembles diffusion of a graph
Similarity propagation resembles diffusion of a graph. A: Propagation graph from Figure 2, redrawn with labels for element pairs (diamonds). B: Similarity propagation on a
whose stationary distribution is given by Eq. (8).
The structure of the pair propagation graph determines how information about element similarities can spread during propagation. For instance, the graph in Figure
Model alignment
A main task in model merging is to detect and combine corresponding elements between models. In such a model alignment the element matching has to be non-ambiguous (an element cannot be matched to several elements in another model) and transitive (if
Given two models
Instead of maximising the score exactly (which would be computationally hard), we employ a greedy algorithm: first, it chooses the element pair with the highest
For aligning three or more models, we use the same matching score (for element pairs), but consider the transitivity constraint: Whenever we match two elements, we also match all their previously determined matching partners (and consider the respective mutual similarities in the score function).
Finding element annotations based on model alignments
Semantic propagation can be used to suggest annotations for non-annotated model elements. For this purpose the considered partially annotated model is aligned to a fully annotated large pathway map. Afterwards, annotations are transferred from elements in the map to the corresponding, non-annotated elements in the model.
As a prerequisite, we collected many annotated model elements appearing in BioModels Database, which served as a replacement for the large, annotated pathway map, and calculated their propagated feature vectors. For each element (
To find annotations for a non-annotated element of interest, we calculate its propagated feature vector within its model and check if there are similar vectors in our collection. Afterwards, the annotations associated with these vectors are presented to the user. The general idea is that given a model from the BioModels Database that lacks annotations for a single feature on a given element, this method would be able to predict annotations for this element with perfect accuracy.
For annotation prediction on the semanticSBML website, the feature propagation algorithm has been slightly modified. To reduce the number of annotations suggested, we set the propagation values
Authors' contributions
MS and WL developed the semantic propagation and wrote the paper. MS implemented the algorithms and analysed the data. MS, EK, and WL designed computational experiments. All authors read and approved the final manuscript.
The authors thank Isabel Rojas for suggesting the idea of semantic propagation, Falko Krause for implementation work in semanticSBML, Ron Milo for kindly hosting W.L. at the Weizmann Institute of Science, and an anonymous referee for valuable suggestions.
This work was supported by the German Research Foundation [CRC 618 and GZ: LI 1676/2-1], the International Max Planck Research School for Computational Biology and Scientific Computing, and the European Commission [grant number LSHG-CT-2006-037469].
Biochemical network matching and composition
Model aggregation: a building-block approach to creating large macromolecular regulatory networks
KEGGconverter: a tool for the in-silico modelling of metabolic networks of the KEGG Pathways database
PINT: Pathways INtegration Tool
Minimum information requested in the annotation of biochemical models (MIRIAM)
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
Correlation between gene expression and GO semantic similarity
Retrieval, alignment, and clustering of computational models based on semantic annotations
A graphical method for reducing and relating models in systems biology
Path matching and graph matching in biological networks
PathBLAST: a tool for alignment of protein interaction networks
QPath: a method for querying pathways in a protein-protein interaction network
Alignment of metabolic pathways
Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways
A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy
Investigating semantic similarity measures across the Gene Ontology: the relationship between sequence and annotation
GOSAP: Gene Ontology-Based Semantic Alignment of Biological Pathways
Simple and fast alignment of metabolic pathways by exploiting local diversity
Biological Network Querying Techniques: Analysis and Comparison
Annotation and merging of SBML models with semanticSBML
BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems
Ultrasensitivity in the mitogen-activated protein kinase cascade
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
Full-scale model of glycolysis in Saccharomyces cerevisiae
SBMLmerge, a System for Combining Biochemical Network Models
ChEBI: a database and ontology for chemical entities of biological interest
KEGG for linking genomes to life and the environment
Topic-based vector space model
Whole-proteome prediction of protein function via graph-theoretic analysis of interaction maps
Global alignment of multiple protein interaction networks with application to functional orthology detection


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Global yuan: a true blessing or a burden for the Celestial Empire?
On 1st of October, the Chinese yuan will join the International Monetary Fund's basket of elite reserve currencies (commonly known as Special Drawing Rights currency basket). At first glance, this piece of news may appear insignificant, you may even wonder why Chinese government exuberates over it. Let us explain why.
The SDR is an international reserve asset, created by the International Monetary Fund in 1969 to supplement its member countries' official reserves. A basket of the SDR currently includes four major currencies – the US dollar, euro, the Japanese yen, and pound sterling. To join the basket, each currency must meet the criterion of being "a freely usable currency". In other words, it must be widely traded in the main exchange markets and widely used to make payments for international transactions. China is well-qualified under one of the two criteria: it is a major global exporter of goods and services. But the yuan does not meet the other criterion – it's not a 'freely usable' currency. Despite this missing characteristic, the yuan managed to become an integral part of the IMF's basket.
Now, when we learnt what lies behind the concept of the SDR currency basket, you may say: "What a cheering piece of news for the People's Republic of China! Yes, indeed, this country need to be rewarded for the years-long efforts to raise its status in the international financial community". But what the yuan's prominence will entail for the Chinese economy? Let's delve into solving this conundrum.
Actually, the inclusion of yuan in the basket of international currencies offers no privilege to the currency issuer. It bears no tangible benefits for the country. China's voice in decision-making process of the IMF remains unchanged so far. Therefore, the fact that yuan has become an official reserve currency is just a symbolic victory of China, a sort of recognition of the country's role in the global economy, and it comes with a string attached to it.
China will have to transform its economy into market-oriented one. It is a subject to less government intervention and broader, more liquid and better-regulated financial markets. China will also need to undertake reforms that engender the trust of foreign investors and make its currency more attractive for investors' asset portfolios. This includes a more open and transparent government, primacy of the rule of law and an independent central bank. Without them China will never gain the trust of foreign investors. Will the Communist Party of China agree to alter its current political line and introduce a package of political, legal, and institutional reforms? I would doubt it. Therefore, the yuan will unlikely replace the US dollar and other SDR currencies from their leading positions.

subset: commoncrawl


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Hair transplant after 45 days now but hair is fallen; why is it? Can I get hair again and density? (Photos)
Doctor Answers 4
Hair is fallen
you would have new growing hair follicles 3-4 mo after HT and normal hair dansity can be obtained in 12-14 months . So it is normal lphase of HT surgery
It is normal to have transplanted hairs fall out weeks after surgery before new hairs grow out. Your doctor
It is normal to have transplanted hairs fall out weeks after surgery before new hairs grow out. Your doctor should have told you this. If you're concerned about this, follow up with your doctor.
Web reference: https://newhair.com
Lost hair after a hair transplant
This is a known condition called Shock Loss which causes the native hair to fall out. The use of the drug finasteride can prevent this from happening
You might also like...
Hair Loss after Hair Transplant #hairtransplantinseattle
- After hair transplantation, the transplanted hair shafts will fall out, and this is normal and expected.
- BUT, the hair follicle under the skin remains.
- Over the next 6-12 months these hair follicles will sprout new hair.
- Hair transplantation results take many months, up to a year, to see your final results.
- Thanks for sharing!
Web reference: http://www.seattlehairclinic.com
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Hey guys!
I just recently got myself hooked up with my first BMW.. 54 plate 318Ci Sport and I'm delighted with it!
I'm looking to get a few parts cleaned up/repaired on it pretty soon and I was wondering if anyone could tell me the best place to get some replacement glass for the wing mirrors as mine are quite faded?
I've had a look on ebay and it looks like you could pick a pair up for around £20 + P+P.
I was also wondering if anyone has feedback about the interior LED kits you can get and also where the best place to get them would be.. I've heard mixed stories about them.
I look forward to hopefully sharing my experienced with the new motor through the forum with you guys and any feedback on the aboce would be appreciated!


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The Old Trafford captain, who has played through enough European campaigns to separate the good from the bad, has given a thumbs down to the latest never-ending format.
Keane and his United team-mates won through as the Group B winners without finding their best form - mainly because they did not have to. "The buzz hasn't been the same. If you lose a game you can still get back into the competition," the Manchester United midfielder said.
"In the past if you lost that was it, you were out. The intensity isn't there any more in these matches. It's been hard to get going. The home games have been disappointing. We've had to grind out results.
"If we play like we did against Sturm Graz when we meet the top teams we would be beaten. We've not been firing on all cylinders but we're in the next stage in Europe. However, we know we need to improve."
Keane predicts that United's slow-burn season will ignite when the opposition provides a bigger challenge. "We've not played great so far but we've not played badly either," he said. "But remember there is a lot left in the team. There are one or two [injured players] to come back. Our training is designed to help us hit our peak later in the season. I don't mind the number of games, because we would only do more running if we weren't playing. We know we will have to raise ourselves against the better players. You don't get the ball back so quickly if you give it away.
"But those games bring out the best in all players and they also excite the fans. It's been quiet at times in Europe this season, but it's also up to us to get the crowd going. United are now in the last 16 as one of the top four seeds and have avoided a draw against Barcelona or Lazio, the two sides we fear most."
However Keane, who has a massive few months ahead of him concerning his future at the club, knows United will have to beat that calibre of side eventually to hold on to their trophy. "Barcelona will be there or thereabouts at the end," he said. "They seem to be hitting form, but hopefully we will do the same later on. We're pleased not to meet them just now but I'm sure they will be happy to avoid us, too. If we had been in the same group it wouldn't have bothered us."
Ole Gunnar Solskjaer, the Norwegian striker who produced his first European goal since last season's final against Bayern Munich in Barcelona when he netted in the 56th minute of Tuesday's 2-1 win over Sturm Graz, said: "Of course it was a nice feeling to score again. I enjoyed myself and had a few chances and should have scored before. But who cares now? I hit it quite cleanly, and it was great to see it go in. We had to win tonight and we want to be the best and win every game.
"As for the next stage, if you want to win it you have to play the best anyway at some stage, so it doesn't really matter who we meet in the next round - so let's just wait and see."
Solskjaer, a spectator for most of this season, needed a lift and says his volleyed goal has done the trick. "Obviously it gives me confidence," he said. "I've been training hard, and so this helps my morale.
"You want to play in as many games as possible. But it is a squad game, and I will play my part whenever I'm needed. You always want to be called up for every game, but that's the manager's decision."
The BBC will broadcast live coverage of United's World Team Championship challenge in Brazil. Sir Alex Ferguson's team will play the Brazilians Vasco da Gama, the Mexicans Necaxa and South Melbourne of Australia in the group stages of the new Fifa event, which begins on 5 January. All three games will kick off at 8.15pm UK time and will be shown on BBC1.
The BBC's Controller of TV Sport, Mike Miller, said: "We are delighted to be bringing Manchester United's quest for world domination to millions of British fans in prime time."Reuse content


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Experts in the epidemiology of diseases in humans are often the frontline of disease research. This branch of medical science investigates and describes the causes and spread of disease and develops the means for prevention or control. Epidemiologists may study many different illnesses, often focusing on major infectious diseases or chronic illnesses.
At a minimum, epidemiologists need a master's degree in public health. In many cases a PhD is required.
Research epidemiologists work at colleges and universities, schools of public health, medical schools, and independent research firms. Clinical epidemiologists work primarily in consulting roles at hospitals, informing the medical staff of infectious outbreaks and providing containment solutions. These epidemiologists sometimes are referred to as infection control professionals.
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|This is a discussion on Poker sponsors within the online poker forums, in the General Poker section; Anyone have experience about poker tournaments and sponsors? Im interested about live tournaments and how to get sponsors and are there some rules for sponsoring. If
Poker sponsors
Anyone have experience about poker tournaments and sponsors? Im interested about live tournaments and how to get sponsors and are there some rules for sponsoring.
If you have personal experience about tournaments and sponsors, let me/us know, share your details and knowledge in this thread, tell your story, im happy to hear it
You need to be a proven and successful winner before anyone would approach you about sponsoring you. And even then you also need to be a professional poker player.
Unless you know someone personally who is interested it is just going to happen.
I know many successful professional players who don't have sponsors. They are looking for people who will get their brand out there in a big way.
Once in a blue moon you might run across an unknown player who is sponsored by a company - in every case they have some kind of connection to them.
Yeah Dakota is right, While I was at the WSOP circuit here in N.C , We had multiple conversations at the tables about this.. And we came to the conclusion, that most of the time if someone is being sponsored, they have already won and are famous enough for people to know that they are good.. and at the same time, sometimes casino's are looking for house pro's who will play for the house, and return a percentage if they win... They are rare, but they are out there.. and they are really good.. You just have to keep your fingers crossed and eyes peeled... maybe wear some logo's of stuff without being sponosored yet, then they may approach you at the table....
Speaking of which im off to the casino now.. good luck
re: Poker & Poker sponsors
Thanks for answers so far. This pretty much same what I thought. I searched world poker tours internet site and there are some rules about sponsoring, exsample in this page (file what need to load first and view then): http://www.worldpokertour.com/Shared..._Montreal.aspx
Someone in that tournament or going to join?
Would be awesome to be in that tournament and win it, there are already 1,173 persons registered and prize pool looks pretty good, so far $3,387,930.


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Ewan McGregor is gearing up make his Broadway debut, it was announced on Thursday. The Trainspotting actor will star in a revival of Tom Stoppard's The Real Thing at American Airlines theatre next year. McGregor will play Henry, a glib and unhappily married playwright, in the Roundabout Theatre Company production, which will run from 2 October 2014 until the following January.
It is a role – and, indeed, a play – with serious calibre on Broadway. Stoppard's drama has been produced twice before on Broadway, picking up Tony awards for best new play and best revival. Both productions delivered best actor and actress wins for its leads, with Glenn Close and Jeremy Irons scooping Tonys in 1984 and Stephen Dillane and Jennifer Ehle following in their footsteps in 2000, after the Donmar Warehouse revival transferred to New York.
McGregor has had a single major nomination for his stage work. In 2006, he was put forward for an Olivier award for his performance as Sky Masterson in the West End revival of Guys and Dolls. Three years later at Donmar Warehouse, he played Iago opposite Chiwetel Ejiofor (now appearing on screen in 12 Years a Slave), who scooped best actor at the Oliviers, while McGregor missed out.
However, he will no doubt be hoping for success in 2015, not least because the production will be directed by Sam Gold, one of the most hotly rated young directors in the US. Gold, who made his Broadway debut in 2011 in Theresa Rebeck's Seminar (starring Alan Rickman), has received enormous acclaim for his productions of Annie Baker's plays, including Circle Mirror Transformation, The Flick and an adaptation of Uncle Vanya.
McGregor's co-star, to play the role of his wife Charlotte, has not yet been announced. The role was originaally played by Felicity Kendal in London, who starred opposite Roger Rees.


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If Theo Walcott or Santi Cazorla hope to get anything in Arsenal's match against Bayern Munich tomorrow, they'll have to do something no player has done since last year: score past Manuel Neuer.
The Bayern and Germany stopper is in fine form, conceding only seven goals in 22 games this season, and hasn't let in any in his last six. His last concession came in a 1-1 draw against Borussia Monchengladbach, and even that was a penalty.
But clearly he thinks there's room for improvement, because he's adopted the weird innovation of a four-fingered (or three-fingered, depending on how you define the thumb bit) glove.
Neuer debuted the weird glove in his side's 2-0 win away at Wolfsburg, and they will make their Champions League debut against the Gunners tomorrow.
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- Arsenal
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The Top 6 Sights To See In Berlin
The German capital is one which epitomizes the changes and the history that the country has experienced over recent decades and centuries, and is a cosmopolitan and vibrant place to visit with a real historic heart. Whether you are looking for cutting edge art, ancient monuments and artistic masterpieces or great views, Berlin certainly has something for you.
Brandenburg Gate
Built at the end of the eighteenth century as an ornate city gate leading on to the impressive boulevard 'Unter den Linden', this is one of the most important historic sites in the city, and is now an attractive monument again after significant restoration. With six impressive pillars and the grand statue of a Roman chariot drawn by four horses, it is one of the most iconic sights in Berlin.
Checkpoint CharlieDuring the years when the Berlin Wall divided the East and West of the city, the main crossing point between the two areas was dubbed 'Checkpoint Charlie' by the allies helping to maintain peace. While the original booth that stood at the checkpoint has since been removed, its popularity as a tourist site meant a replica was erected, and nearby sections of the Berlin Wall are used as a gallery tracing the history of the checkpoint.
Kollhoff TowerLocated on a prominent plot on Potsdamer Platz, this tower was designed by Hans Kollhoff in his New Classical style which uses red brick to help the building stand out. There is a viewing platform that offers some nice views across the city, but it is also noted for having the fastest elevator in Europe to take visitors up to the viewing platform which is over 100 meters above street level.
Berlin Philharmonic OrchestraBerlin is a city that is known for its vibrant cultural scene, and one of the musical highlights of a visit to the city is the chance to see the orchestra in action. Located in the impressive Philarmonie building that was completed in 1963, it is a truly wonderful experience and it is often possible to pick up last minute bargain tickets if the show is not a sell out.
Street Art In Berlin
The German capital is at the forefront of modern art in the country, and outside the main tourist center there is a wealth of art and graffiti to be seen. While it is possible to research beforehand and to walk around many of these sites yourself, joining a tour is a great way to get a quick look at the main modern art pieces, and to see the work of several artists in a relatively short space of time.


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You missed it This great deal for Maderas Golf Club is over. But don't despair, we've got more great deals every day.
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Maderas Golf Club
Give Dad the Gift of Golf this Father's Day with 18 Holes for Two or a Membership Package
99% recommendedin LivingSocial customer ratings
Play one of San Diego's only courses on Golf Digest's Top 100 list for 2013 -- we're talking about the breathtaking Maderas Golf Club in Poway. Take in the gorgeous sights, including lakes, waterfalls, and 40 acres of wildflowers:
• $175 ($420 value) for a a golf package for two people
• $89 ($187 value) for 2013 Maderas Advantage Program Silver Membership
• Other impressive accolades from Golf Magazine, Golfweek, and more
The golf package welcomes two people to play 18 holes of golf any one weekday or weekend day through August 31. You and your guest (we recommend you consider taking Dad) will receive a cart, driving range access, and unlimited range balls.
2013 Maderas Advantage Program Silver Membership treats you like a VIP by offering you discounted weekday, weekend, and twilight rates; one guest per visit at your membership rate; three-day advance booking window; the ability to earn a free visit for every seven rounds played; discounts on shop merchandise, lessons with a PGA pro, food, and beverages; and more.
PAID VALUE EXPIRES ON May 29, 2022
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From the launch event on September 25th 2014 in Trieste (IT) to the presentation of the Roadmap 2016 on March 1oth in Amsterdam (NL), ESFRI has carried out an important refinement of its method and has produced a new strategy document identifying new projects and consolidated landmarks as well as a thorough analysis of the European Landscape of Research Infrastructures accessible to European scientists and developers.
On 28 January 2016, scientists of the KM3NeT Collaboration have publicly announced KM3NeT 2.0, their ambition for the immediate future to further exploit the clear waters of the deep Mediterranean Sea for the detection of cosmic and atmospheric neutrinos. The published Letter of Intent details the science performance as well as the technical design of the KM3NeT 2.0 infrastructure.
In December 2015, scientists and engineers started the installation of KM3NeT.. Once completed, it will be the largest neutrino detector in the Northern Hemisphere. Located in the depths of the Mediterranean Sea, the telescope will be used to study the fundamental properties of neutrinos and map the high-energy cosmic neutrinos emanating from extreme cataclysmic events in the Universe.
A "Deep Ocean Cabled Observatories" workshop – examining potential synergies between astroparticle physics and marine and earth sciences – was held at NIKHEF, in Amsterdam, on 24-25 May this year.
The conference revealed many areas in which physics can collaborate with other disciplines – with the deep-ocean physics installations providing the perfect opportunity to accommodate such devices as seismometers and hydrophones, to gather data for varied researches…
The "Deep Ocean Cabled Observatories" workshop will be held at NIKHEF, in Amsterdam, on 24-25 May this year. The event will bring together marine scientists and astroparticle physicists to discuss the research potential of cabled observatories.
The first day of the workshop will focus on current research being undertaken in Canada, the Mediterranean and the United States; the second day, however, will concentrate on the future – looking at what answers…


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Food, Festivals, Music: What To Do Labor Weekend in St. LouisThe fun starts tomorrow, don't miss the food and fun happening this weekend around St. Louis.
12 Ways to Fall Asleep When You Can't Stop Tossing & TurningWhat is your go-to method for falling asleep?
The Best Places To RetireRetirement can mean a time to travel and relax. Find out the best places to retire in America.
Top 10 Ways To Relax On Labor Day Weekend (On The Cheap)


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Tulkinghorn has participated in many a dull conference call, but has never quite had the courage to pass the time in the same way as some Linklaters associates.
It has reached Tulkinghorn's attention that a traditional game called 'conference call roulette' has done the rounds for many years, providing a forum for young lawyers to prove their strength and bravery among peers. To play, the willing candidate apparently hammers the mute button while on a conference call until they no longer know whether the mute function is active.
At this point, the candidate takes a deep breath and roars an obscenity down the phone at full blast. If silence follows, accompanied by a partner's heavy footsteps down the corridor, then the associate can be assured that their tale will be the stuff of legend – even if they don't have the longest of careers.


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BBC Merlin: Revenge Chapter Eight
"What happened?!" Merlin shook himself.
"Welcome back to the land of the living!" Arthur said, pleased to see his friend was ok.
"He won't be for long and nether will you!" Benjamin shouted.
Both Merlin and Arthur had witnessed the power this boy possessed and knew not to take this threat lightly.
"Look, just calm down. I know your upset about your sister's death but it wasn't Merlin's fault. He didn't kill her!" Arthur tried desperately to reason with the boy.
Merlin quickly gathered his thoughts that were still swimming wildly around his head. Arthur must have been informed on the fact that he had killed Nimueh but the problem was whether he should deny it or not. Deny it and maybe Arthur would belive him but except it and Arthur might lop his head off. Arthur wouldn't do that though. The head loping that is. However Merlin decided not to risk it.
"How are you so sure?" Benjamin asked.
"Because I just know." Arthur said rather rubbishy.
"Enough of this! I will kill you!"
"Wait! Think about what your doing Benjamin. Do you really want to become a murderer? Could you live with yourself? Think about it." Merlin told the boy, even surprising Arthur with this new found wisdom.
"I…of course I…I'm not a kid!" Benjamin stuttered.
"Yes you are. Don't do this." Arthur said, taking a few steps towards Benjamin.
Benjamin stumbled off the rock and shrunk away.
"Back down! I'm warning you!"
Arthur had learnt in the short time he had known the boy that his threats were by no means hollow and stopped in his tracks.
"I am sorry about your sisters death. I truly am." Merlin said. Meaning every word of what he said. He was not proud of killing Nimueh even though she had been evil and had almost killed Gaius and countless others.
"What do you mean?! You killed her!" Benjamin cried, falling back a few steps.
Merlin knew that down right denying the fact he had killed Nimueh would only angry Benjamin more but admitting to it would cause Arthur to loose his trust in him so he just stayed silent.
"Stop saying that! Merlin didn't kill her! Did you?" Arthur directed the last question at Merlin.
"I…umm…" Merlin flicked his eyes from Arthur to Benjamin, not knowing what to do.
"What? You did?!" Arthur frowned, assuming that Merlin's silence was guilty, though not truly believing it.
Merlin thought quickly. Keep his magic secret and possibly anger Benjamin so much he would kill them both or admit the truth and die anyway. He had decided.
"No, of course not." He told Arthur, feeling hatred coming off Benjamin in waves.
"Do not lie warlock! You killed her!" Benjamin yelled.
"No, I did not. Don't call me a warlock ether. I don't have magic." Merlin said, hating that he was having to lie to Arthur about his magic yet again.
"Well that settles it. We are leaving!" Arthur said turning to go.
"Fine! Go!" Benjamin shouted, "But Merlin's staying!"
"Leave us alone! He said he didn't kill your sister!"
"He is a liar, soon to be a dead one."
"No chance." Arthur pointed his sword at arms length at Benjamin.
"No, wait Arthur! Benjamin, you don't have to do this. You can come back with us. Start a new life. Forget everything! Revenge won't bring your sister back." Merlin tried desperately to persuade Benjamin to change. He hated seeing a boy so young like this and he wanted to help him.
Suddenly Benjamin seemed to listen for once and appeared to be mulling this offer over carefully. Merlin marvelled at the mature attitude the boy had suddenly adopted that was so unlike a child.
"Do you really think that Nimueh would want you to be like this?" Merlin knew the answer was probably yes but maybe Benjamin wouldn't see it like that.
"I…I…don't know…I…"
"Merlin! We can't have a sorcerer come back with us! Are you mad?" Arthur declared suddenly.
Benjamin looked up from his thoughts, looking suddenly scared and venerable.
"No it's all right. No one needs to know he's a sorcerer." Merlin took a few steps towards Benjamin, holding out a hand.
"Come on. You can come with us." He said.
Benjamin shrunk away from Merlin's hand like it was a poisonous snake. Merlin suddenly noticed that the boy was getting closer and closer to the edge of the platform.
"No! It's ok. Don't move." Merlin stretched his hand out further, trying to coax the young child towards him.
"No…stay away…" Benjamin took another step towards the edge, a few stones rolling off and falling into the endless darkness below.
Arthur had noticed to and tried to help Merlin.
"Don't move!" He yelled as Benjamin took a step that wasn't there and fell with a shout.
"No!" Merlin cried and leapt to the edge, kneeling down and peering over the side in a frenzy. Benjamin was clinging onto a small jutting out rock by one arm, his legs failing around in the air, a look of complete terror on his face, all traces of maturity gone. He just looked like any other frightened little boy.
"Grab my ankles!" Merlin yelled to Arthur, preparing to go over the edge.
"Just do it! I'm going to save him!"
"Wo-" Arthur began to protest but Merlin looked as though he was going over the side, Arthur holding him or not, so reluctantly he grabbed Merlin's feet and lowered him over the ledge, jamming his own feet into two small holes in the rock for support. Immediately his bad arm, the one the wolf had got to, began to hurt.
"Grab my hand!" Merlin shouted to Benjamin, reaching down for all he was worth.
"I can't!" Benjamin cried, tears of terror streaming down his face.
"Swing! Reach!"
Benjamin did as advised and began to swing precariously on his hand, reaching up with the other. Their hands touched briefly but the sweat on both of them caused them to slip away again.
"Lower me down further!" Merlin shouted up to Arthur.
Arthur bent his knees to achieve the maximum of his ability, flinching as his bad arm throbbed with the strain.
"I can't hold on!" He yelled, his feet slipping slowly out of the dents in the rock.
"Come on!" Merlin said, extending his arms to lengths he didn't even know were possible.
Benjamin had both hands on the jutting out rock but as he tried again to grab Merlin's hand one of them slid off, a few small pebbles falling off the ledge.
"MERLIN!" Arthur puffed. Hs arm wasn't going to take much more of this.
Benjamin's face suddenly took on a calm serenity. He knew he wasn't going to be able to reach Merlin's hand and he also knew that Arthur couldn't hold on forever and it would all end up with them all going over the edge. Merlin read the thoughts that were clear in Benjamin face.
"No." He chocked so quietly it was barely audible, shaking his head gently.
Benjamin's face briefly twitched with something that Merlin didn't have time to register and then with a final tear rolling down his face he let go.
Everything went into slow motion, time seemed to stop and Merlin lost all acknowledgement of everything around him, even sound. All he saw was Benjamin's body falling until the overwhelming blackness encased him. He didn't want to breath. He didn't need to breath. He didn't need to do anything. He just needed to stare, as if that would bring the boy back.
Arthur gave the final ounce of his energy and heaved Merlin onto the platform. His first concern was his arm, which had opened up again and needed rewrapping which he did. He looked at Merlin who seemed to have frozen, a glazed expression on his face.
"…Are you alright…?" Arthur asked. Merlin took a moment to turn his head.
"I could have saved him." He croaked. He could have done. He could have used his magic to help him but he hadn't. It hadn't occurred to him. He hadn't had enough time.
"It's my fault he's dead." He looked down at the floor.
"No. It's my fault." Arthur said, slumping down beside Merlin. "I should have lowed you down more."
"Don't blame yourself."
"I won't if you won't"
Merlin smiled.
Arthur got up and offered a hand down to Merlin.
"Come on. Lets go home."
The End


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Oxnard Pet Adoption – Adopt a Preloved Dog or Cat in Oxnard CA
Oxnard pet adoption listings. Pet Rehoming Network showcases dogs and cats for adoption in Oxnard and area.
The dogs and cats listed for adoption are being placed directly by their owners, who can no longer care for them due to a variety of understandable reasons.
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While Oxnard's animal shelters and pet rescue organizations provide a much needed service for pets in need, they are really no place for pre-loved family companions that are used to being pampered. Pet Net Oxnard helps facilitate home-to-home pet adoptions, so that family pets need never "set paw" in a shelter or rescue.
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Bold digital prints, like Seventh Wonderland's black and white floral silk-twill pants, will give your summer wardrobe the wow factor. Team this tapered style with a simple tank to complete a monochromatic power pairing.
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Ubuntu 10.04 Alpha 2 Removes HAL
The development of Ubuntu 10.04 is taking another turn. Lucid Lynx now has a second alpha version that gets rid of HAL.
"HAL" unfortunately isn't the heinous supercomputer from Kubrick's film 2001, but Ubuntu's Hardware Abstraction Layer between Ubuntu's hardware and software. It has now disappeared entirely from the current Ubuntu 10.04 test version, it's function being taken over among other things by DeviceKit. The advantage to this, according to the official announcement, is that Ubuntu has a faster boot and startup from hibernate time.
Alpha 2 provides Kernel version 2.6.32-10.14 and has the newest GNOME and KDE packages on board. The GNOME desktop is version 2.29.4 and KDE is 4.4 RC1. Interestingly, the three proprietary versions of NVIDIA graphics drivers (190.53, 173 and 96) can be installed at the same time without a problem, provided only one is configured for use. In the past the automatic installation of the wrong driver version via Jockey could lead to a failed graphical interface in some applications. Further enhancements went into Ubuntu's Enterprise Cloud (UEC) that is now based on Eucalyptus 1.6.2.
As usual, the announcement warns about known issues with implementing Alpha 2. Removing HAL has the consequence that Wacom drivers can no longer be used for drawing tablets. Desktop ISOs from Kubuntu no longer fit on a CD, so they need to be burned to a DVD or USB stick. A LiveCD reboot can freeze on the boot logo on systems supporting Kernel Mode Setting (KMS), which may indeed be a Plymouth error. The workaround is to boot from USB stick instead of CD. The notification bubbles are rather hideous at the moment, as the notification system is still in debug mode during the development phase.
Debug mode is more or less the state of all of Ubuntu 10.04. The usual message is that the alpha is an unstable system not to be deployed in production. Nevertheless, downloads come in a variety of flavors:
more to linux than ubuntuthis is frustrating. it's not 'ubuntu's HAL'; HAL is distribution agnostic.
quit using ubuntu to mean linux!
Cloning Linux systemsStomfi, I think you'll find that has more to do with the Linux kernel and available modules than HAL.
HAL was already removed in the RC1This post says that HAL was actually removed in the RC1 itself to make the boot faster. Apparently, there were some performance regressions because of that. It would be interesting to know if the regression has been sorted out.
Cloning DrivesI run a not for profit that refurbishes donated hardware with Ubuntu and gives it away to the digital divide.
HAL made it relatively easy to clone a configured and updated source drive and install it in different hardware.
Will DeviceKit give the same functionality?
I'd hate to have to go back to a base install.
HAL is/was NOT heinous...Despite what many say about the beloved HAL9000, he was not a heinous psychotic computer that went nutty and killed the crew of the discovery. As you find out in 2010, the second movie, he was PROGRAMMED to do what it did - it was not something HAL did on his own.
As a sidebar, c'mon people - it's 2010 and no HAL. Let's get with it! HAL should already exist. Of course, he would be Linux-based... Yes, I admit it - I am sickly infatuated with the HAL9000, and also admit that he is my inspiration behind choosing a career of computer programming...
Issue 199/2017
Buy this issue as a PDF
Red Hat Announces OpenShift.io
Red Hat takes its IDE online.
Microsoft Bakes Linux into Windows Server
Microsoft is slowly becoming a Linux vendor.
Fearless Coyote, Linux Kernel 4.11 is Out
The new kernel makes swap implementation more scalable, which will help cloud providers.
Docker Appoints Steve Singh CEO
The new CEO comes from a very strong SaaS background.
Docker Announces Linux Kit and Moby Project
Both projects help organizations build their own containerized systems.
Ubuntu Returns to Gnome as Its Mobile Plans Shatter
Mark Shuttleworth has resumed the position of CEO of Canonical.
Microsoft is Shutting Down CodePlex
Microsoft's open source code hosting platform CodePlex will come to an end after a more than 10-year stint.
Fedora 26 Alpha Released
Comes with Gnome 3.24
Old Linux Kernel Bug Discovered
The bug was introduced back in 2009 and has been lurking around all this time.
OpenSSH 7.5 Released
The new release deprecates the sshd_config UsePrivilegeSeparation option.


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One in Four U.S. Hackers is an Informer
So successful are the FBI and Secret Service at turning U.S. hackers, that as many as one in four of all hackers are, or have at some been, working for the government.
So says The Guardian which says the threat of long prison sentences is enough to turn cybercriminals into cybergrasses.
So ubiquitous has the FBI informant network become that Eric Corley, who publishes the hacker quarterly, 2600, has estimated that 25% of hackers in the US may have been recruited by the federal authorities to be their eyes and ears


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ED Magedson – Founder
Ripoff Report
Benefits USA - Consumer Health Care - Alliance Health3150 N. 7th Street Phoenix, Arizona U.S.A.
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
This report was posted on Ripoff Report on 04/16/2008 11:00 AM and is a permanent record located here: http://www.ripoffreport.com/reports/benefits-usa-consumer-health-care-alliance-health/phoenix-arizona-85014/benefits-usa-consumer-health-care-alliance-health-slippery-representation-misleadin-326500. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
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SUBMITTED: Thursday, April 17, 2008POSTED: Thursday, April 17, 2008
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María Elena González: Tempo
February 9th - March 18th 2017
February 9th - March 18th 2017
In Tempo, Cuban-American artist María Elena González explores the translation between the acoustical and the physical. Riffing off of her celebrated "Tree Talk" series, González creates new work in wood and in porcelain that simultaneously function as both sculpture and musical instrument – addressing the inherent sound of the materials and sound as a material for sculpture.
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Seems so long ago, and yet just like yesterday.
Looking down on my family and sending love.
Knowing they still remember and miss me.
Aloha, Pupster
Today is Martin Luther King day and also the holiday that I went to the Rainbow Bridge 7 years ago. That year the actual date was the 21st. Mom usually uses the 21st, but just happens to be off work today and wanted to do my diary. Not that she ever forgets.
Peanut, her 1st Chi is coming up on her 14th B-day in May.
Lovey will be with her 7 years in 2 & 1/2 weeks.
Aloha' Pupster :-)
Today would have been my Birth day.
Mom never forgets.
I feel special.
Love and aloha to her, Peanut, Lovey.
Thank you for always remembering me.
Copyright © I-5 Publishing, LLC. All rights reserved.
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Grizzly | Model: H8361
60" x 30" Heavy-Duty Birch Workbench
Price: $515.00
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Sized to fit the needs of any shop, this super heavy-duty Birch Workbench has a solid 3" thick top that measures 60" long x 30" wide and stands 38" above the floor. The end vise measures 14-3/4" wide and has a 7" maximum capacity. Stable laminated birch provides strength and durability. Includes a non-toxic Durakryl finish, which is food safe, resistant to mars/stains, and cleans up with warm soapy water. You'll be proud to have this workbench in your shop! Approximate shipping weight: 254 lbs.
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By the time I had recovered from the mutant animal attack, breakfast was being served. I sunk to the floor with shaky legs, waiting for my stomach to stop turning. How many more surprise attacks could we take? It was just pure luck that we were alive now.
'So um where are you from?' I heard a voice beside me and I glanced over to find Robbie leaning against the wall, a bag of fruit loops in his hand.
'Urm, Nottingham. Have you heard of it?'
Robbie's expression turned thoughtful. 'I've heard the name but I can't for the life of me figure out where it is.'
'It's in the East Midlands,' I told him, fighting a smile. 'What about you?'
'Oh, that's in London right?'
He nodded, munching on some cereal.
I decided to open my own and as soon as I caught a whiff of the sugary loops, my stomach growled furiously at me and I realized I was starving. We didn't have any milk and so we had to eat them as they were, but I didn't mind.
'Um, why is there a hairbrush beside me?'
'Oh,' Robbie laughed. 'I saw it and thought you might want it.'
'Oh,' I grinned. 'Thanks.'
I was beginning to feel comfortable in front of Robbie, he was extremely easy to get along with as soon as his walls were down. I sensed he had some trust issues, the way he kept glancing nervously at the others told me this, but I noted he seemed okay with me.
We ate in silence for a few minutes until Tyler stood up.
'We should probably make a move now,' he declared, stretching.
Madelyn picked up Cookie, who mew'ed in content and Robbie stood up, offering me his hand. I took it shyly, noticing how warm his skin was against mine. Tendons along his arms stood out as he helped me up and I blushed furiously, appreciating his well muscled body.
'So where to now?' I asked, fighting to keep my voice steady.
'I'm not quite sure,' Tyler frowned. 'We should probably just check each room as we go and see if there's a way out.'
'Sounds good to me,' Madelyn smiled.
Tyler lead the way out of the room with Madelyn following closely behind.
'After you. It's probably safer if I go at the end, in case someone decides another surprise attack.'
I smiled my thanks and followed the other two out of the room and back into the hallway.
Doors loomed ahead of us on either side. There was no way to distinguish between any of them; they were all completely identical.
'Which door should we try first?'
'The one closest to us perhaps?' I suggested.
'It's probably better to do them in order,' Tyler agreed.
As we made our way over to the first door, the floor began trembling ever so slightly beneath our feet. Small, uneven tremors spaced out every two seconds or so, until they gradually morphed into one, long shudder.
'What the...'
Before any of us could do anything, something rounded the corner with a ferocious growl. We all whirled round, guns at the ready to find this incredibly large beast bounding it's way towards us. When I say large, I mean huge, it had to be the size of a horse. Sharp fangs coated in saliva hung out of snarling muzzle, paws that created resounding thuds each time they hit the floor pushed this terrifying animal towards us.
The beast didn't flinch at the bullets that were now raining down on it. It was getting much closer. I didn't notice it until it was only a few yards away, but the terrifying yellow eyes were focussed on me. Me alone.
I was going to be killed!
Glued to the spot, I willed myself to move but my muscles had frozen and now refused to work.
In one last ditch attempt, Robbie threw himself in front of me and the beast pummelled into him. They both fell to the floor with a grunt and Robbie instantly began fighting off the creature. We could all see it was futile though, Robbie was an ant compared to the animal who was much stronger and much bigger. He was going to be killed.
However the animal wasn't interested in Robbie. It's snarling head turned to face me and it hissed, trails of saliva shooting out of it's mouth.
The next few moments to me are a bit of a blur. All I remember is the animal charging towards me, a shrill, high pitched scream and then absolute darkness.


text:
Men standing in loblolly pine stand after thinning
Item information
- Title:
- Men standing in loblolly pine stand after thinning
- Topics:
- Subjects:
Agricultural extension work
Loblolly pine
Forest thinning
Forest management
- Original Format:
- Black-and-white print (photograph)
- Item identifier:
- ua023_007-008-bx0031-013-003
- Photographer:
- Graeber, R. W., 1888-1967 more info on Graeber, R. W. (Robert Walter), 1888-1967
- Created Date:
- Description:
- Transcribed from back: A 31-year-old stand of loblolly pine from which 8.5 cords of thinning have been cut and leaving 185 choice trees per acre--farm of R. H. Moore, Edgecombe County.
- Genre:
- Location:
Edgecombe County (N.C.)
- Digital Project:
University Archives Photographs
Source information
- Repository:
- Special Collections Research Center at NCSU Libraries
- Collection:
- Agricultural Extension and Research services (UA023.007) held by Special Collections Research Center at NCSU Libraries
- Note field:
- Not all materials from the physical collection may have been scanned. Images may have been enhanced for web access.
- Rights:
- For questions regarding copyright or permissions, please refer to our Reproduction, Use, Citation, and Copyright page (http://d.lib.ncsu.edu/collections/about).


text:
Tips galore
Avoiding the 'just an extra handful'
Compost and chickens
One of our Challenge Champions, Kirsty Phillipson-Lowe, has sent in some lovely photos via Twitter to show us what happens to leftovers that aren't made into other meals.
Here are the compost bins - made by Kirsty's husband reusing old pallets - where most of the family's vegetable waste goes...
... and the chickens get the leftover cabbage!
Ageing fruit
Leftover risotto
And now for the savoury...
On Twitter, Valerie Wong has shared this photo of her delicious-looking savoury bread and butter pudding, which used up leftover baguette, garlic and thyme from Sunday's roast.
Kirsty's Bread and Butter Pudding
Kirsty Phillipson-Lowe - who writes the blog Hijacked by Twins - has sent in this recipe for Chocolate Orange Bread and Butter Pudding, which she made use up some home-made fruit loaf. (We think that's double frugal points!)
Bread (as much or as little as you've got - I had about 10 slices of fruit loaf and brioche)
Orange marmalade
400ml milk
2 eggs at room temperature
25g caster sugar
100g chocolate
Spread butter on one side of the slices of bread
Spread marmalade over the buttered slices of bread
Layer the slices, butter and marmalade side up, in an oven-proof dish. Leave to one side
Melt the chocolate in a glass bowl over a pan of boiling water
Place the milk in a pan and heat to just below boiling point
Whisk the eggs with the caster sugar
Remove the milk from the heat and stir in the eggs and sugar mix
Stir in the melted chocolate
Gently pour the chocolate custard over the bread allowing the bread to soak up the custard
Leave for half an hour to soak up more custard and add extra as needed (depending on the amount of bread you have used you may not need all of the custard made)
While the pudding is standing pre heat the oven to 180C
Spoon on some extra marmalade onto the top of the pudding and place in the pre-heated oven and bake for 20 minutes
This pudding is delicious served hot with ice cream, fresh cream or custard. It is also just as good the following day cold and a great way to use up and enjoy what otherwise would have been thrown in the bin.
Banana update from Betty Bee
I have been trying to use up those things which always seen to get left behind. Namely two bananas who were going soggy in the fruit bow. Putting them in the freezer makes their skin goes black but means that they can be used to make banana bread or blitzed into a milk shake but I decided to try a no fat, no dairy ice cream recipe. Just take the bananas out of the freezer, peel them and put them in a blender or food processor with some honey and blitz. It's as easy as that and does taste incredibly creamy even though it's never been near a cow!
Salmon fishcakes
Here's one food waste challenge going well...
An ingenious answer to the small bean question
One of our commenters suggests:
Leftovers fajita-style
Spag bog all week?
Emesdawn is wondering how far she can stretch some mince - will spag bog every night lead to revolution?
Where can you buy small tins of beans?
Marjorie Hodson has a small broccoli stalk confession - and wants to know where she can find small tins of beans:
This week I have thrown away half an orange and some old broccoli stalks which I should really have used but they somehow didn't fit in. They went into the compost so weren't completely wasted. We have an allotment so don't usually need to shop for veg. In fact our most frequent shopping is for fresh fruit and milk, although we also freeze some milk. I keep one drawer of the freezer for left overs, veg for soup, pasta also for soup or just for one portion meals.
We like to add beans, any really, cannellini, butter, haricot to single helpings of stew or casseroles so that they do another meal for both of us. Any leftover beans can make a winter salad with onion, herbs, apple or anything you have. If anyone knows where I can buy small tins of beans I would be very happy.
'Everything but the kitchen sink' meatloaf recipe
Siobhan McGuinness - who writes the blog Vohn's Vittles - has kindly let us post her recipe for meatloaf which, as its name suggests, leaves no leftover ingredient unused.
75g pancetta
1 tsp oil
1 onion, finely chopped
5 garlic cloves, crushed
450g chicken livers, trimmed
350g beef, minced
350g pork sausagemeat
50g breadcrumbs
25g ground pistachios
25g chopped hazelnuts
1 tsp Season-All
½ tsp ground sea salt
½ tsp freshly ground black pepper
50ml milk
2 eggs, beaten
Fry the pancetta until crispy, then remove from pan. In the same pan, add 1 tsp oil and fry the onion over medium heat until soft. Add garlic and fry for another ½ minute, then remove pan from heat and leave to cool.
Purée chicken livers in a blender. (Mmm – meaty milkshake!)
Pour blended chicken livers into a bowl and add pancetta, onions, garlic, minced beef, sausage meat, breadcrumbs, nuts, seasonings, milk and eggs. Mix well. (It will look thoroughly disgusting!)
Pour the mixture into a 2lb loaf tin, cover with foil and then place loaf tin in a roasting tray containing an inch of hot water.
Bake at 180ºC for an hour and a half, removing the tin foil for the last 15 minutes and topping up the water in the roasting tray if necessary. Don't worry about the burnt-looking edges – they are very tasty!
Leave to cool slightly before turning out and slicing.
We had it served with boiled potatoes and winter greens, then another night with chips & gravy. For National Toast Day I had the leftovers for lunch on oat and barley toast topped with green olives!
One-pot, 'clear out the fridge' meal
Lisa's Tagine
Lisa Bennison used Sunday dinner leftovers to make this lamb and apricot tagine, accompanied by flat breads from her store cupboards.
Tips from Teacher100
One commenter shares some personal tips for avoiding food waste.
If use by, best before and display until labels on food packaging leave you puzzled, read our handy guide to food date labels.
The Flexitarian
Annabelle Randle - who writes The Flexitarian blog - has sent in two great recipes for using up leftovers
Panzanella Salad
200g country crusty bread (1 to 2 days old)
3 large tomatoes
1 cucumber
1 small red onion
175ml olive oil
2-3 tbsp of red wine vinegar
1 small bunch of basil (shredded)
jar of 290g of kalamata olives (optional)
salt & pepper
Cut the bread into 2.5cm (1 inch) cubes
Cut each tomato into 8 slices
Cut cucumber in 1cm (1/2 inch) cubes
Slice red onion finely
Mix all the vegetables and the bread in a large salad bowl
In a separate bowl prepare the dressing by mixing olive oil and vinegar and season with salt and pepper
Add the dressing to the vegetable and bread mix.
Toss well so that the bread is well coated
Add olives plus shredded basil
Toss well to mix and leave to rest for 30mins before serving
Banana Spelt Bread
4 large over-ripe bananas
200g currants
100g caster sugar
250g plain flour
250g spelt flour
2 tsp baking powder
2 tsp bicarbonate soda
150g walnut pieces
Place the currants in a bowl and cover with boiling water
Pre-heat the oven to 180C/350F/Gas 4
Grease and flour a rectangular cake tin (approx. 25 x 11x 7cm)
Put all the dry ingredients in a large bowl. Mix well. Mash the bananas with a fork until puréed
Add bananas to the dry ingredients
Mix thoroughly - It might look dry at first but it will blend together, and you might find it easier to use a food processor
Drain currants and add them to the mixture alongside the walnuts
Mix well
Pour mixture into the cake tin and even the dough
Cook for around 55 mins or until an inserted cake skewer comes out completely clean
Check from 45 mins onwards
Cool completely before serving
Keep up to 3 days in an airtight container
Cooking for one
Siobhan Davis
On the first day of her challenge, Siobhan cooked this delicious-looking pizza from scratch using flour from her cupboards, passata, garlic and herbs for the sauce, some sad looking veg, and mozzarella.
Laura Radford
Now I will openly admit that I am terrible when it comes to wasting food. If I don't finish a plate, it's straight in the bin and the thought of: 'What could I do with these leftovers?' doesn't even cross my mind. I might be good at freezing batches of food but when it comes to portion size, I've never been a good judge and I am sure lots of you will say the same.
I live on my own and in all honesty it is very difficult to prepare a meal for one person from scratch. Even the vast majority of ready-meals, in my opinion, have a big enough portion of food to share. So naturally when I came across the Guardian Live Better challenge I thought: 'What a good way to try and cut down my food waste and actually be conscious and aware of what I am wasting, and how I can stop it.' I even kept a newspaper clipping of the Guardian Live Better advert from on my fridge to remind myself.
I made sure that I adhered to the rules of no additional food shopping being allowed, and I even took it a step further by not buying any food whatsoever for the house throughout the week. The Guardian Live Better rules state that you can buy milk, bread and they even stretched the allowance to eggs (quite right too as it was Shrove Tuesday last week).
I did well in preparation because I had already done a food shop and I didn't need any of the above basics. I also had a well stocked freezer of meats, some oven food and decent dry goods in my cupboards. I was fully prepared for the week ahead and to eat only from my cupboards. I have to say I found it a lot easier than I thought.
Initially when I took on the challenge, I had very little faith in myself. I thought I'd either forget I was doing it or just continue to waste food, because it really was about changing habits for me. I rarely think when I am throwing leftovers in the bin so I had to work to change my mind set around that. I really think this challenge will have a positive effect for me not to waste food in the future. After all there are millions of starving people in this world; the least I can do is finish a plate.
Diane West
Betty Bee
I very rarely throw away any food. My two top tips are not to stray too far from people's likes and if you have a freezer learn to use and manage it. I find my biggest food challenge is using up the storecupboard contents especially those random purchases that somehow end up in there.
So far during the challenge I have made a rice pudding using up a can of evaporated milk which I don't remember buying, along with some UHT milk, sugar and a stray vanilla pod.
There's been a lentil and coconut milk stew which wiped out half a bag of sorry looking lentils, a tin of long forgotten coconut milk, as well as some random spices. It wasn't that bad all things considered.
However, my biggest achievement so far was the grapefruit jelly cobbled together from two left over gelatine leaves and some sorry looking fruit.
It's certainly been a worthwhile challenge so far and it has inspired me to cook from scratch using what I have rather than what I need to buy.


text:
|Price incl. VAT
|£25.58 £21.90
|Price excl. VAT
Innovative headset system in size medium, with which you can lavaliere microphones and smartLav + used as a headset. You talk to them with a smaller distance and your recitation will be cleaner. Gripping you the freedom for other activities during the call. Thanks ergonomic shape to set well-worn microphones and on it are firmly seated.
The design of a flexible steel excels in its simplicity and therefore durability. Long retains its shape and its weight is only 5 grams of it because you will not know for a while.
Functions and features:
Innovative System
Ergonomic shape
Flexible steel
Suitable for: lavalier microphones, smartLav +
Dimensions: 100 mm x 140 mm x 200 mm
Weight: 5 g
Specifications can be changed without notice. Images are for illustrative purposes only. Retail Price (MSRP) means the manufacturer's/supplier's suggested retail price.
Link to Manufacturer's Website: Enter link to the external review


text:
Chapter 7.1Mature
"Did anyone see you?" Matteo asked as they ran along the road away from Adrianna's house.
"I don't think so," she replied, trying to get her words in between breaths. "And if they did, nobody came out to stop me."
"That's good. Was it difficult getting away?"
"Fooling my father was the easy bit. It turns out escaping from a bedroom window and climbing down a tree is slightly more complicated than I had first thought."
"I'm not surprised," Matteo laughed breathily. "You're wearing a tent."
"I'll have you know this is the height of fashion," Adrianna exclaimed, pretending to be mortified. "Matteo, can we slow down?" Her pace slowed, dragging her companion to a quick walking pace. "I've done enough running for this evening. How far is it to the meeting? Are we walking all the way?"
"Only part of the way. I have a carriage waiting for us on the edge of town. We should be at the meeting in fifteen minutes at the very most."
"Good," Adrianna said quietly, nodding to herself like she had to make sure she fully understood. "Are we very late?"
"Only a bit, but no one will mind. The meeting can't start without us anyway."
"I don't want people hanging around for my sake," Adrianna protested.
"I think you're going to have to learn that not everything is about you," Matteo teased. "It's not you they're waiting for."
"They're waiting for you?"
"No need to sound so surprised," Matteo chuckled. "I think you'll find I can give quite the inspirational speech when the occasion calls for it."
"I don't doubt it," Adrianna replied, smiling to herself and looking wide-eyed up at her companion's face. "So what are you speaking about tonight?" She asked, snapping herself out of the dreamlike state she had allowed herself to slip into.
"Now if I told you then it wouldn't be a surprise. No one knows what my speeches will be about beforehand, not even me."
"You mean you haven't written it?"
"Not in so many words, no."
"Are you mad?" Adrianna exclaimed. "Making up a speech, on the spot, in front of a group of people. That would terrify me."
"But that's the thrill of it. Once you feel their eyes on you and the blood starts pumping faster through your veins; there's no other experience like it."
"It's my idea of torture."
"Is it any different from talking to the group of people you met last night?" Matteo asked, one eyebrow raised questioningly. "Because that's all it is. Sharing your ideas with like-minded people. There is just a little more added pressure when you give a speech because everyone is listening to you, but the chances are they will all agree with you."
"I'm not sure. I don't know many people who share my opinions."
"Well you're about to be introduced to quite a few more." Matteo smiled affectionately at his companion, a smile that sent ripples of warmth through Adrianna as she smiled shyly back. "Here we are," Matteo suddenly said, his focus shifting in an instant.
He led Adrianna over to a small buggy, just big enough to fit the two of them, the horse standing patiently tied to a hitching post at the edge of the rough road.
"I didn't dare bring her all the way up to your house," Matteo explained, "because I was scared I would draw attention to myself, and there were no hitching posts nearer to you so I had to leave her here. We wouldn't want our transport wandering off without us."
"Of course not," Adrianna replied, laughing a little at Matteo's half-joke. She approached the buggy, wondering how she would be able to get in without appearing unladylike, when Matteo offered her his hand.
"Allow me," he said. Adrianna gratefully took his hand and stepped gracefully up and onto the seat, trying as hard as she could to stop her skirts from spreading too much.
Matteo bounded up elegantly beside her, taking his seat quickly and picking the reigns up from their position wrapped around the handrail in front of him.
"Hold on tight," he said, winking at Adrianna before he urged the horse forward. He managed to pick up a lot of speed very quickly, making Adrianna grip tightly to the edges of the buggy, a wild grin on her face. In any other situation she might have felt scared, but now her stomach was filled with excitement as they flew along the road. Somehow, Matteo's presence next to her made her feel safe. She trusted him with her life.
The streets flew by, going first towards the centre of town, then away again, heading for the suburbs. Adrianna lost track of where they were going, just enjoying the ride.
When they finally stopped they were in a part of town Adrianna did not know. There were no gaslights on the streets and she could see very little as Matteo tied the horse to a hitching post outside a tavern. A sign swung above the entrance, a golden lion on its hind legs, and the letters underneath the image declared that this wasThe Prancing Lion.
"It doesn't pay to linger too long out here," Matteo said, quickly helping Adrianna down from the buggy. "I'll have the doorman watch our horse. He's a trustworthy fellow and I know he'll stop anyone who dares steal it."
Adrianna immediately felt fear return to her chest. She was clearly in a part of town her father wouldn't even consider her going to and if she was discovered then it wouldn't be worth her living any longer.


text:
Richmond's Knee and Shoulder Specialist
Thank you for voting Dr. Goradia and G2 Orthopedics and Sports Medicine in this year's Best Bedside Manner in Our Health Magazine! We are humbled, appreciative and proud to serve Richmond.
Get The Right Treatment
Every patient and injury is different. We take the time to provide the right diagnosis and individualized treatment plan. We care for all patients the same way we care for professional athletes, using advanced treatments to get them
back to peak levels in sports, work and day-to-day life.
Knee Pain
Common Knee Problems:
Shoulder Pain
Common Shoulder Problems:
Stem Cell & PRP
Read More:
Some Plans Include:
Ashley Wells, Vollyball Player
"I have had trouble with my knees for years and got to the point of constant pain. My parents took me to other surgeons but they were skeptical about being able to fix my knee.
After spending hours online researching numerous physicians throughout the area, Dr. Goradia's experience really stood out. I'm happy I took the time to choose the best place for my care. After surgery and rehab I'm now able to play high school volleyball."
Leon Sydnor, Firefighter
"I had a great experience at G2. Friends that went to other doctors were out of work for months.
Because of Dr. Goradia's skill I made a full recovery just 4 weeks after removal of a torn meniscus in my right knee. I would highly recommend him to anyone!"
Katie Duncan, Student Athlete
"I tore my ACL during a high school All-Star Soccer game. After 2 months of conditioning at college, my knee was giving out and causing a lot of pain. A friend recommended Dr. Goradia.
I was able to get an appointment quickly and an MRI the very same day I saw him. Six months after ACL surgery I was back to playing soccer!"
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I have since returned to Dr. Goradia for other orthopedic needs because of the speed and accuracy of his treatment."
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I had put off having surgery for years because I was concerned about the recovery time and how it would impact my business but with the limitations of my injury beginning to impact my livelihood, I finally reached a point where I had to do something.
I specifically chose Dr. Goradia based on his experience and credentials in sports medicine. I had surgery on a Friday and returned to work the following Monday. As for my procedure, Dr. Goradia 'rocked it' and I would gladly recommend him to any of my clients."
See more Patient Success stories here.
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