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Deep Learning/Machine Learning (General): Companies that build computer algorithms that operate based on their learnings from existing data. Examples include predictive data models and software platforms that analyze behavioral data.
Deep Learning/Machine Learning (Applications): Companies that utilize computer algorithms that operate based on existing data in vertically specific use cases. Examples include using machine learning technology to detect banking fraud or to identify the top retail leads.
Natural Language Processing (General): Companies that build algorithms that process human language input and convert it into understandable representations. Examples include automated narrative generation and mining text into data.
Natural Language Processing (Speech Recognition): Companies that process sound clips of human speech, identify the exact words, and derive meaning from them. Examples include software that detects voice commands and translates them into actionable data.
Computer Vision/Image Recognition (General): Companies that build technology that process and analyze images to derive information and recognize objects from them. Examples include visual search platforms and image tagging APIs for developers.
Computer Vision/Image Recognition (Applications): Companies that utilize technology that process images in vertically specific use cases. Examples include software that recognizes faces or enables one to search for a retail item by taking a picture.
Gesture Control: Companies that enable one to interact and communicate with computers through their gestures.
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Surfers Beach Resort One
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Is this the same place?!!!
... malls/restaurants etc… and plenty of people out and about and out on the beach – which stretches as far as the eye can see in either direction.
Our room at the Hilton wasn't ready when we checked in so we headed up to the Executive Lounge for some refreshments whilst we waited. (We purchased a voucher online for our 3 night stay here – didn't even realise ...
Off to Disneyland today going to be so much fun. I travelled by taxi. I've already been to Hong Kong Disneyland and I loved it and I'm glad I'm back. The students are really going to be stoked to go to Disneyland. Some of them have never been outside of Australia. The first ride I go on is called the Pitch Black Roller Coaster. It is 2 minutes ...
Australia. Melbourne to Brisbane
... views. Me and Jill opted for a Steak, Charlie had some revolting looking seafood pasta thing which seemed to go down a treat and Anthony had pasta bolognaise. We met Claire who is one of Charlies friends for a drink at Opera bar afterwards and after a long catch up and talk about her new life in Sydney which sounds pretty amazing we all headed back to the Vibe which we had to ourselves again as the girl band had flown back to America! Our time in Sydney was coming to an end. We had ...
Rollercoasters & high rise buildings
Me & Catherine hired a car-she was a bloody marvellous driver and I was too much of a scaredy cat to get behind the wheel-so I essentially had a chauffeur for the weekend, thanks lady-you were awesome. We went from Brisbane to Surfers paradise, for the sole purpose of scaring ourselves shitless on some awesome roller-coasters. As she was driving I did the navigating- really badly and got us driving around in circles at least 5 times in the first ...
19-21 January: Two nights in Surfers Paradise
... two new pairs of flip flops, a shorts and two new tops. The sun luckily came out shortly after noon, so I spent the whole afternoon relaxing on the beach, while Julia continued shopping. Julia joined me on the beach a few hours later, and I tried to go for a swim, but the waves were simply way too big. In the evening we went for a walk and decided to spend some time just enjoying the luxury of our hotel-like hostel room. On Wednesday ...


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हेर्नुहोस भिडियो
She sang loads of well known society tunes like 'Pirati mama Dum chha', 'jimmal baauki chhori', 'Uhi Mulako Sinki Uhi Mulako Chana' and numerous others including teej Songs. She is known as a glamorous,hot and intense, disputable vocalist in Nepali lok Dohori melody industry. She is beautiful,attractive and pleasant entertainer on the stage.
There are numerous discussions yet her most recent video got debate because of her over presentation on a society music video. She has dependably been scrutinized by open that she wears too short dresses while performing on the stage or whether offering meeting to media.
Tune Title : Suhaulaa ra Dohori Ma Rap
Vocal : Khuman Adhikari and Samjhana Magar
Verses : Baburam Bohara
Music : Khuman Adhikari
Creation and Distribution : Tirsana Music Pvt Ltd
Acting : Baburam Bohora and Jyoti Magar
Course : Shankar B.C.
Camera : Suresh Shrestha
Altering : Nabin Gharti Magar
Video Made by : Krishana Filims PVt LTd


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Possibly the most powerful custom Window API for Microsoft Windows yet... It is a C++, MFC extension that aids not only creating but dynamically changing all of the user-interface furniture of your application, e.g. menus, buttons, windows, etc.
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It's time to ask something very important for me:
I'm from Italy and I work as musician, or, I try, with a lot of problems. Here in South italy, it's all so narrow-minded that is impossibile to grow as artist, the best you can achieve is to take part of a cover band (a lot of Tribute bands..) investing hundreads of euro for 40 50euro per live, or create you own project but almost all clubs don't want unreleased music, and if you join a Festival, is, of course, without any payment.
And I don't want to talk about "quality of life" cause I feel ashamed.
I'm planning to leave this place and try a long, or short experience in another city of Europe. I'm ready to find a job to sustain, but with the awareness that music is seen with respect and not just as hobby. I'm reporting a lot about the most important cities in Europe, London, Berlin, Paris, but it's also recomended to consider also other cities, cheaper, not so much crowded.. so..help me..I think Aj could be the right place to ask this kind of suggestion.. Hope you can help me, and thank you so much for your time
Amsterdam has a pretty cool music scene from my experience. I haven't been to many other European cities. I am personally planning to move to London within the next 2 years and I would definitely say it has an awesome music scene. Every band that comes to England will at least play London. Lot's of film, media, music stuff going on there too for aspiring composers But like you said, London is very crowded, but I like that.
Wow, in these last weeks I was really impressed by Amsterdam and that's the first choiche for the time being. About England I'm attracted by Brighton..can you say something more about it?
LucaFormicola said
Wow, in these last weeks I was really impressed by Amsterdam and that's the first choiche for the time being. About England I'm attracted by Brighton..can you say something more about it?
I'm not surprised, it's a lovely chilled out city, which is really fun to ride bikes around! ha.
Ah yeah I really like Brighton, great music scene too, lovely seaside. I can't tell you much more, but I've been there several times just because it's a nice place to walk around. I'm not sure how much is going on there in terms of multimedia/film companies etc though. Google can help you out there
Thanks I'll google it..
Some other suggestions?
There's TONS of musicians here in The Netherlands and we are certainly not narrow-minded. You will find countless gigs all over the country, medium and huge festivals in about all the music styles you can think, not even counting the mini-gigs in all the local pubs. That certainly is plenty. People are passionate about it, but then again it also matters to what type of people you talk to. Really, I could be visiting 2 partys/gigs per day, 365 days per year, if I really wanted to. And that's probably just within 1 or 2 music-styles
But make a living out of it? I doubt so. The Netherlands rather gives their money to Greece, to playing USA's lapdog on supporting their military missions, to huge bonusses for managers, to design-hats for our queen, etc. The money-flow towards cultural & artistic things has been closed to a great extend. Local TV stations rather buy cheap stuff on stock-sites like this one, instead of hiring a local expensive composer.
Amsterdam, Praque, Hamburg…Barcelona maybe
I've been living in Dubai for about 3 years. Don't want to be disrespectful to that place but maaaaan that was some narrow minded music stage. I was teaching music and playing in the national philharmonic there. Tried my best to form a band and do something but nothing came out. They did pay insane amounts of money for short gigs…playing either jazz standards or classical music. Not so much creativity in the process…
Now I moved to Germany (my wife is from here) since about 1 year. I totally love it. I live in a medium size city. Besides teaching, I play in 2 established bands and collaborate for different gigs with others. First 2-3 months were quite hard but after I made some connections, things began to flow soooo good. There is a stage for any kind of music and any kind of music is totally appreciated. In Germany I easily found people to share musical ideas with and work on lots of projects.
Another way of making some good money and get creative was to get in touch with theater people. It always works. Just went on the site of the local theater company, found an email adress, submitted some of my previous works and within some weeks I was contacted and asked if I can come up with some music for a show.
So…I totally recommend Germany…I wouldn't recommend the bigger cities though. Maybe for later. Regarding language, of course its always nice when you speak it at least on a small conversational level but in this line of bussiness…english works great. As a teacher I even had more students because people wanted to practice also their language skills
And as a last piece of advice…Don't feel shy on doing research, get in touch with people, write emails, ask questions, send your music,etc.
Hope it helped a little bit at least. Best of luck and do let us know about how things work out
Dubai!... That is where I lived for a very long time. not 3 years not 5 not even 10 but 14+, I got to agree with you it has a narrow minded music stage, but you can make money there from music. Being from a European descent. Just playing in a hotel lobby could get you a lot of money. I've never did that, but there were things like battle of the bands where local rock bands competed against each other. Finding a drummer for me as a kid was the hardest thing to do though he he


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From the Department of Infection and Immunity (Drs Dockrell and Whyte), University of Sheffield Medical School and Sheffield Teaching Hospitals, Sheffield; and the School of Immunity and Infection (Dr Mitchell), College of Medical and Dental Sciences, University of Birmingham, Birmingham, England.
Correspondence to: David H. Dockrell, MD, Department of Infection and Immunity, The University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, England; e-mail: firstname.lastname@example.com
Funding/Support: This work is supported by a Wellcome Trust Senior Clinical Fellowship to Dr Dockrell (076945) and by Wellcome Trust and Medical Research Council (MRC) grants to Drs Dockrell, Whyte, and Mitchell. Drs Dockrell and Whyte are also funded as part of the MRC-Association of the British Pharmaceutical Industry COPD consortium and the TJM laboratory by the European Community's Seventh Framework Programme under Grant Agreement No. HEALTH-F3-2009-223111 (CAREPNEUMO).
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Information for commercial entities is available online.
Vaccination and antimicrobial therapy remain the cornerstones of the management of pneumococcal pneumonia. Despite significant successes, the capacity of the pneumococcus to evolve in the face of the selective pressure of anticapsular immunity challenges immunization programs. Treatment focuses on antimicrobial therapy but ignores the central role of the dysregulated inflammatory response during pneumonia. Future therapeutic approaches need to build on the considerable recent advances in our understanding of the pathogenesis of pneumococcal pneumonia, including those from models of pneumonia. Enhancement of the essential components of the host response that prevents most colonized individuals from developing pneumonia and strategies to limit inappropriate inflammatory responses to lower respiratory tract infection are approaches that could be exploited to improve disease outcome. This review highlights recent discoveries relating to the microbial and host determinants of microbial clearance and regulation of the inflammatory response, which provide clues as to how this could be achieved in the future.
Streptococcus pneumoniae (the pneumococcus) is the leading cause of community-acquired pneumonia. The incidence of pneumococcal pneumonia is greatest at the extremes of age and in individuals with medical comorbidity. Pneumococcal infection causes approximately 2 million deaths globally and costs hundreds of billions of dollars per annum. Streptococcus pneumoniae frequently colonizes the nasopharynx and from the nasopharynx, pneumococci can spread directly via the airway to the lower respiratory tract, causing pneumonia, or to the sinuses or middle ears, causing medical morbidity. Bacteria may also penetrate the epithelial cell surface, resulting in local infection or bacteremia. The pleura and meninges can be seeded by local spread of infection or by bacteremia. Invasive pneumococcal disease (IPD) is defined as isolation of bacteria from a normally sterile site, such as blood, cerebrospinal fluid, or pleural space, and results from invasion of the respiratory epithelium.
Antimicrobial therapy and vaccination have been central to the clinical approach to pneumococcal disease, but efforts to enhance the host response, other than through immunization, have received limited attention. This is somewhat surprising because colonization with the pneumococcus is widespread and development of pneumonia is a comparatively rare event. This review focuses on recent findings relating to the microbiology and pathogenesis of pneumococcal pneumonia and includes data from murine models of pneumococcal disease. Murine models of pulmonary infection have provided valuable insights because they have allowed the manipulation of molecules or specific cell populations to test their role in a model system of pneumococcal pneumonia.
Streptococcus pneumoniae demonstrate transformation and horizontal gene transfer, ensuring a high rate of variation in the genome. Pneumococci acquire environmental DNA from a number of sources, including the extracellular matrix of pneumococcal biofilms, which contain DNA,1 and via microbial fratricide, whereby noncompetent siblings are lysed, facilitating release of chromosomal DNA.2 The "distributed-genome hypothesis" posits that pathogenic bacteria have a large number of noncore genes (the "bacterial supragenome") not present in all strains, maintaining diversity. Analysis of eight pneumococcal strains colonizing children, and comparison with nine freely available strains, revealed that 54% of genes were not found in all strains and that any individual strain possessed only 21% to 32% of these noncore genes.3 Whole genome sequencing of 240 isolates of serotype 23F, strains associated with multidrug antimicrobial resistance, has revealed that 74% of the genome was altered in at least one of the sequenced strains.4 Recombination hot spots were not just related to genes encoding antimicrobial targets, but were also concentrated in genes encoding capsular biosynthesis and adhesins, targets of the immune response. These findings suggest that current vaccine strategies provide, and future vaccine strategies should provide, a potent selective pressure for pneumococcal genetic evolution and that pneumococci will likely continue to evolve in response to the selective pressure exerted both by the immune response to vaccines and by antimicrobials.
At least 92 different serotypes of pneumococcal polysaccharide capsule exist, the most recently described being serotype 11E.5 A systematic review and meta-analysis compared the risk of death with specific serotypes, using serotype 14 as the reference strain.6 Results were compared with adults with low comorbidity scores to reduce confounding by host factors. Serotypes associated with an increased risk of death during bacteremic pneumonia included serotypes 3, 6A and B, 9N, and 19F, whereas serotypes 1, 7F, and 8 were associated with a lower risk of death. The serotypes associated with an increased risk of death were those strains that cause lower rates of IPD following pediatric colonization.7 These strains are less likely to invade but when they do, IPD results in a higher mortality than observed for other strains (Table 1). Colonizing strains behave as "opportunistic infections" in individuals with medical comorbidities, whereas strains with a higher propensity to cause IPD when carried in the nasopharynx behave as "primary pathogens" in medically fit individuals.11
Serotypes of Streptococcus pneumoniae were grouped as either associated with colonization and relatively low rates of IPD per 100,000 acquisition events or as being associated with relatively high attack rates of IPD per 100,000 colonizing events, as described by Sleeman et al7 in a pediatric population, and the relative frequency of various characteristics compared. IPD = invasive pneumococcal disease.
The behavior of serotype 14 has some features of strains associated with low and some features associated with high attack rates.
The ability of pneumococci to colonize and invade has been related to a variety of factors, including phase variation. In this process, the colony morphology for an individual serotype can vary between transparent and opaque when viewed on transparent agar with oblique transmitted light. Transparent phenotypes colonize the airway readily, whereas opaque phenotypes are well able to survive in the bloodstream and resist phagocytosis.12 Opaque phenotypes have a number of characteristics favoring survival following tissue invasion, one of which is the presence of increased encapsulation.13
Differences in the capsule among serotypes are also an important determinant of the variation in biologic behavior among serotypes. Colonizing strains are more resistant to nonopsonic killing by neutrophils,8 a key determinant of nasopharyngeal carriage.14 Capsular switch studies, in which different serotype capsules are swapped onto an otherwise identical genetic background, confirm that differences in capsule account for much of the variation in biologic behavior. Capsular serotype also influences tissue invasion; serotype 6A or 23F capsule is associated with reduced accessibility of adhesins, including pneumococcal surface protein, choline-binding protein A, and pneumococcal serine-rich repeat protein (PsrP), resulting in decreased adherence to epithelial cells and increased ingestion by alveolar macrophages (AMs), when compared with the more invasive serotype 4 capsule.9 Capsules from invasive serotypes, such as serotype 4 and 7F, are more resistant to complement deposition and opsonin-dependent phagocytosis than are capsules associated with colonization, such as 6A and 23F,10 although variation in complement deposition is not mediated solely by capsular serotype.15
Thus, colonizing and invasive strains have evolved to exploit unique ecologic niches and have acquired the necessary adaptations to evade the key immune responses controlling bacterial replication in their location (Fig 1). The colonizing strains with reduced invasive potential escape nonopsonic neutrophil-dependent phagocytosis but, when they do translocate into the distal airway, are more easily cleared by AMs and more readily cleared in the lung or bloodstream by complement-dependent mechanisms. This may explain why they less commonly cause invasive disease. In contrast, the strains of greater invasive potential are readily cleared from the upper airway by neutrophils but if they escape neutrophil-mediated clearance they can more easily bind to epithelial cells via adhesins and translocate across the epithelium, as suggested by Weinberger and colleagues.8 They are also more resistant to AM- and complement-mediated clearance, explaining their relative success as invasive strains.
Strains associated with colonization have thicker capsules produced at lower metabolic cost.8 Serotype replacement is a well-recognized phenomenon after protein conjugate vaccination,19 and colonizing capsular serotypes that evolve with the selective pressure of vaccination are predicted to be those with the larger and less metabolically costly capsules.8
A cholesterol-dependent cytolysin named pneumolysin is a critical virulence factor for pneumococci,18 but recent work has highlighted that both the direct effects of the toxin on cells and the immune response to the toxin may influence pathogenicity. Moreover, an increasing number of pattern-recognition receptors are shown to be involved in the innate immune response to pneumolysin. The capacity of pneumolysin to form membrane pores that lyse cells and to activate complement T cells, neutrophils, or macrophages at sites of infection is well established. Recent attention has focused on the pattern-recognition receptors involved in sensing pneumolysin.
Toll-like receptor (TLR) 4 was the first pattern recognition identified to interact with pneumolysin.20 However, not all innate responses could be linked to TLR4 engagement; a recent study identified TLR4-independent pneumolysin responses, including dendritic cell activation and production of interferon (IFN)-γ and IL-17A by T cells. This study noted the ability of pneumolysin to synergize with TLR engagement to stimulate cytokine production by macrophages and dendritic cells.21 Pneumolysin stimulated caspase-1-dependent processing of IL-1β, which is required to secrete the leaderless protein IL-1β. The authors observed PLY-dependent caspase-1 activation is dependent on the nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) P3 inflammasome and the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) adaptor protein (Fig 2),22 thus implicating a pattern-recognition receptor other than TLR4 in pneumolysin recognition. The authors also established a requirement for pore formation by pneumolysin and activation of the lysosomal protease cathepsin B for IL-1β release.
These results have been extended by another group, who showed that a number of strains of pneumococci that express a pneumolysin, which lacks pore-forming activity, are impaired in their capacity to induce NLRP3-dependent IL-1β secretion.25 These strains include the highly prevalent serotype 1 strain ST306, which causes empyema and disease outbreaks. These findings suggest that some strains' success at causing invasive disease is related to their capacity to evade pattern-recognition receptors such as NLRP3. They also suggest, however, that the lower mortality associated with these strains might be linked to their lower potential to induce proinflammatory responses. The highly virulent serotype 1 strain 4496 (ST3018, lineage C) expresses pneumolysin of reduced hemolytic potential, which shares some of the mutations associated with other strains of reduced pore-forming activity but also has some unique mutations.26 In a murine model of invasive disease, a mutant-expressing pneumolysin from strain 4496 resulted in increased levels of bacteremia in the first 15 h of infection but also increased survival as compared with an isogenic mutant-expressing toxin of full hemolytic potential. In murine models, NLRP3-associated responses enhanced pulmonary clearance of pneumococci from the lung and moderately reduced lung injury and mortality.21,25 Another group have suggested that the impairment in IL-1β and IL-18 secretion and the host response to pneumolysin is more markedly perturbed in the absence of ASC, as opposed to NALP3, and have implicated a further inflammasome receptor that also uses ASC, absent in melanoma 2, as contributing to the host response to pneumolysin.27 In conclusion, NALP3 and potentially other inflammasome receptors have emerged as important mediators of host immunity to pneumococci. Strains that do not engage this recognition system may have a survival advantage that facilitates their spread into the bloodstream but, once in this location, their reduced capacity to generate inflammatory responses may result in improved survival.
Multiple other virulence factors contribute to pneumococcal pathogenesis.28,29 Two recent findings merit emphasis. PsrP is a pathogenicity island-encoded adhesin, which has emerged as contributing to lower respiratory tract virulence and in binding to the lung epithelium but does not contribute to colonization or sepsis. Recently, PsrP has emerged as playing an important role in bacterial aggregation and the maturation of biofilms.16 Murine models demonstrate biofilm formation in the lung, and mutants lacking PsrP induce less biofilm formation, potentially impacting biofilm-mediated resistance to phagocytosis and to antimicrobials. The second finding relates to another pathogenicity island-expressed virulence factor, the production of pili. Pili were not recognized as virulence factors in pneumococci until relatively recently and are only expressed by certain strains.17 Their expression, however, enables bacteria to survive in the lung and to bind to epithelial cells. In addition, piliated strains trigger a greater tumor necrosis factor-dependent inflammatory response, with the potential to cause lung injury and facilitate tissue invasion.
Upper airway colonization is thought to precede the development of pneumonia. Colonization is, however, a frequent event in comparison with pneumonia and in most cases does not lead to the development of clinical disease. T helper cell (Th)17 T-cell responses are key in clearing colonizing bacteria.14 The phagocytic effectors of Th17 T-cell-dependent bacterial clearance will, however, vary, depending on whether the host has been previously exposed to pneumococci. In naive mice, recruitment of macrophages aids clearance of colonizing bacteria, whereas in mice with prior colonization, neutrophils mediate more rapid bacterial clearance. Key events in the innate recognition of colonizing bacteria have also been defined. Nod2-mediated recognition of peptidoglycan fragments degraded by lysozyme M is critical for macrophage-mediated clearance of colonizing pneumococci and enables CCL2 chemokine production and recruitment of further macrophages.23 The macrophage response also requires the presence of pore-forming pneumolysin, and Davis and colleagues23 suggested that this could aid the cytosolic translocation of peptidoglycan fragments into the cytosol. TLR2, which recognizes lipopeptides expressed by pneumococci, made a smaller but additional contribution to CCL2 production. Nod2-dependent responses were also required for the development of Th17 responses and for adaptive immune responses to colonizing bacteria.
Type 1 IFN signaling reduces pneumococcal carriage because IFN-α/β receptor knockout mice are more heavily colonized with pneumococci compared with wild-type control mice.24 Type 1 IFN signaling is initiated by pneumococcal DNA that gains access to the cytosol via pore formation by pneumolysin and activates IFN-β production via the cytosolic sensor DNA-dependent activator of IFN regulatory factors. Influenza A virus triggers a synergistic enhancement of type 1 IFN to that produced during pneumococcal colonization, and this can inhibit the macrophage-driven CCL2 response required to clear colonizing bacteria.30 These studies illustrate how sensing of bacteria by a range of pattern-recognition receptors (eg, TLR2, Nod2, DNA-dependent activator of IFN regulatory factors) in the upper airway leads to Th17 and type 1 IFN responses and clearance of bacteria by macrophages and neutrophils. They also provide clues as to how viral infections can subvert innate responses to colonizing bacteria (eg, by inhibiting the early CCL2-dependent macrophage responses). TLR responses to colonization can, however, modify epithelial integrity, favoring translocation of bacteria. Recent work has shown that p38 mitogen-activated protein kinase- and transforming growth factor-β-mediated responses lead to upregulation of SNAIL1, a transcriptional repressor of claudin-7 and claudin-10, which are required to maintain epithelial cell tight junctions.31 This illustrates the key concept that the inflammatory response must be carefully matched to the host's requirements and that, although underproduction of key cytokines can hinder bacterial clearance, excessive production can favor tissue invasion and paresis of key effector functions, including phagocytosis.
Colonization and microaspiration of upper airway contents are frequent events, and clearance of colonizing bacteria can take a few weeks.14 The comparative infrequency of pneumonia suggests that efficient host responses must operate in the lower airway to protect against pneumonia. A number of components, including the cough reflex, the mucociliary escalator, and mucous and humoral factors in the lower airway, protect the airway from bacteria; however, cell-mediated host defense is critical. AMs are the resident phagocytes that clear bacteria from the lower airway and clear finite numbers of bacteria when these reach the lower airway.32 The capacity of the AMs to clear bacteria can be overwhelmed in the face of medical comorbidities that alter their clearance capacity for bacteria, such as COPD.33 They are also compromised by coexistent viral infections, in particular HIV.34 Factors such as cigarette smoking that result in alternative as opposed to classic activation of AMs also compromise the macrophages' capacity to clear bacteria.35
Differentiated tissue macrophages have a large lysosomal compartment36 and, when the killing capacity of AMs is exhausted, lysosomal permeabilization and activation of cathepsin D leads to apoptosis-associated killing of bacteria.37 Cathepsin D activation leads to a reduction in protein translation and enhanced proteasomal degradation, with the result that levels of proteins with short half-lives, such as a key regulator of macrophage survival, the antiapoptotic protein Mcl-1, are reduced, allowing induction of AM apoptosis.37,38 Bacterial killing in AMs undergoing apoptosis involves reactive oxygen species (ROS) and nitric oxide (NO) and occurs at a stage when conventional microbicidal killing has become exhausted. Enhancement of the conventional mechanisms of intracellular killing, such as the generation of NO via inducible NO synthase, reduces the requirement for apoptosis-associated killing and can be achieved in animal models by administration of granulocyte-macrophage colony-stimulating factor.39 Thus, it seems that apoptosis-associated killing becomes essential in settings in which the macrophages' capacity to control ingested bacteria is stressed and ensures a bacterial clearance process, minimizing the inflammatory response.37 Enhancement of the AM capacity to clear bacteria is, therefore, an attractive, but so far unexploited, aspect of the therapeutic approach to pneumonia.
If the initial inoculum of bacteria cannot be contained by AMs and other elements of the lung's innate host defenses, then neutrophils are recruited to control bacterial replication. Macrophages and epithelial cells co-operate to generate CXC chemokines and other factors that activate a neutrophilic response (Fig 3).43 Although neutrophils are potent effectors of bacterial clearance, their recruitment results in the clinical features of pneumonia and runs the risk of causing lung injury. There is considerable scope, therefore, to manipulate neutrophilic inflammation during pneumococcal pneumonia. Neutrophil recruitment during pneumococcal infection requires the β2 integrin Mac-1, but not lymphocyte function-associated antigen, and also involves the α4/β1 integrin (CD49d/CD29).43 Neutrophil killing of pneumococci does not require NADPH oxidase-dependent generation of ROS but is dependent on the generation of the neutrophil serine proteases cathepsin G and neutrophil elastase.44,45 In the absence of NADPH oxidase-generated ROS, mice tolerate greater numbers of neutrophils in the lung without a concomitant increase in lung injury.46
In addition to modulation of neutrophil recruitment or generation of antimicrobial molecules, the neutrophilic inflammatory response might also be modulated by manipulation of the cytokine network. Deletion of myeloid-expressed phosphatase and tensin homolog deleted on chromosome 10 enhances macrophage phagocytosis and killing of pneumococci. Deletion of phosphatase and tensin homolog deleted on chromosome 10 also reduces proinflammatory cytokine production and neutrophil recruitment, resulting in reduced lung injury and improved survival with pneumococcal pneumonia.47 Turning off proinflammatory cytokine responses at the appropriate time is also key to ensuring the appropriate resolution of neutrophilic inflammation. For example, an important role for triggering receptor expressed on myeloid cells-1 has emerged in both amplifying early inflammatory responses but also downregulating the later phase of the inflammatory response via upregulation of IL-1R-associated kinase M, a negative regulator of TLR signaling.48 Matrix metalloproteases 2 and 9 cleave IL-17A, also reducing neutrophil recruitment to the lung.49
A further critical part of the resolution phase of pneumococcal pneumonia is the clearance of apoptotic neutrophils by macrophage efferocytosis. In addition to enhancing neutrophil function, galectin 3 enhances macrophage efferocytosis and ensures less lung damage arises during pneumococcal pneumonia.50 The manipulation of neutrophilic inflammation is an important goal because a subset of individuals with pneumococcal pneumonia die with a dysregulated inflammatory response despite complete clearance of bacteria.
The adaptive arm of the immune response is also critical to the host response to pneumococci. B cells are critical for antibody responses to naturally occurring infection and immunization, but review of their role is beyond the scope of this article. T cells contribute to the pathogenesis of pneumococcal pneumonia. T-cell numbers increase in the peribronchiolar region early during the evolution of pneumonia.43 Nevertheless, the exact role of T cells in pneumococcal pneumonia has been debated. Recent experiments suggest that CD4+ T-cell numbers or activation may adversely impact the cytokine network and survival during pneumococcal pneumonia.51 Conversely, CD8+ T cells may play an important role, regulating Th17 T-cell numbers in the lung, production of CXC chemokines, and neutrophil recruitment, and in their absence, survival is impaired during pneumococcal pneumonia.52 Nevertheless, a certain level of CD4+ T-cell responsiveness is required for an optimal response to pulmonary pneumococci in many settings; Th17 responses improved bacterial clearance in immunized mice53 and monocytes primed Th1/Th17 responses to pneumococci via IL-12 production.54 These findings suggest that the composition and activation state of T-cell populations must be tightly regulated in the early stages of pneumonia to maximize bacterial clearance but to ensure that the inflammatory response is kept to a minimum. Invariant natural killer T cells are also emerging as contributing to the host response to pneumococci and, following IL-12 or glycolipid-driven activation, contribute to IFN-γ production and bacterial clearance, enhancing early microbial clearance and limiting inflammation.41,42
The ongoing evolution of pneumococci will continue to challenge immunization protocols. An improved understanding of how early immune responses can be enhanced and how neutrophilic inflammation can be more tightly regulated will lead to the development of more rational therapeutic strategies. In order for this to occur, the wealth of information derived from basic science and animal studies needs to be translated to patient groups, and novel therapeutic approaches manipulating the host response must be developed, building on these findings. Areas of attention should include building a more accurate molecular understanding of the basis of susceptibility. This can be achieved through application of findings relating to the early steps in the immune response to subclinical infection and the early stages of pneumonia. Such knowledge could be used to better stratify patients who are at risk for enhanced immunization programs or other preventive strategies. In addition, a better understanding of the core components of a successful inflammatory response to pneumococcal pneumonia is needed. This can inform therapeutic approaches that maximize bacterial clearance but minimize the inflammatory consequences both to the lung and systemically. These aims may seem aspirational, but the constant evolution of the pneumococcus demands that we develop innovative approaches to combat a major global cause of medical illness.
Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Whyte has received travel support for scientific meetings from Boehringer Ingelheim GmbH. She has received competitive external grant funding from a number of noncommercial sources, including the Medical Research Council (MRC) and the Wellcome Trust. Dr Dockrell has received grant support from the Wellcome trust and the MRC. He has received financial support to attend clinical meetings from ViiV Healthcare, Gilead, Bristol-Myers Squibb, Merck Sharp & Dohme Corp and Janssen-Cilag Pty Limited, and has received grant support from Novartis AG. Dr Mitchell has reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Role of sponsors: The sponsors had no role in the design of the study, the collection and analysis of the data, or in the preparation of the manuscript
alveolar macrophage
apoptosis-associated speck-like protein containing a caspase recruitment domain
invasive pneumococcal disease
nucleotide-binding oligomerization domain-like receptor
nitric oxide
nucleotide-binding oligomerization domain
pneumococcal serine-rich repeat protein
reactive oxygen species
T helper cell
toll-like receptor
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Phim Tâm lý - Tình cảm Elles - Elles Trailer VietSub HD Anne (Juliette Binoche), a well-off, Paris-based mother of two and investigative journalist for ELLE, is writing an article about student prostitution. Her meetings with two fiercely independent young women, Alicja (Joanna Kulig) and Charlotte (Anais Demoustier), are profound and unsettling, moving her to question her most intimate convictions about money, family and sex.
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Cyber security and internet freedom statistics by country. Which are most and least safe?
Archive by Author
Happy Birthday to The Collider – Mar 18th
Celebrate The Collider's 1st birthday at a fundraiser promising delicious food, craft brews, fine wines, live jazz, and more!
Zenposium 2017
A second chance to see some of Zenergy's most popular agile and QA presentations from their internationally renowned speakers and thought leaders.
The Future of "Tech" in Our Region: UniteWNC
Getting seriously legit around Tech takes more than a derivative, knock-off moniker…
WordCamp Asheville 2017, June 2-4, 2017
Speaker submissions are now being accepted – through March 14.
Mobile Technology Conference
BRCC Small Business Center 'Call for Speakers' on mobile technology.
Listen in: advancing climate change issues in Trump era
The federal government's role in studying climate change will change under President Donald Trump. One of the many controversies during the first two weeks of his administration is a push to prevent federal agencies that are studying the climate from publicizing their research.
Backpacks to Briefcases (paid internships)
Mountain Area Workforce Development Board announces Backpacks to Briefcases, a paid internship program for recent college graduates who are unemployed or underemployed. If you know of recent college graduates who would like to participate or if you know of local businesses who would like to host the internships, contact Nathan Ramsey at firstname.lastname@example.com. The cost […]
'Civic hackers' help build community solutions for Asheville
ASHEVILLE – Everything changed when the members of Code for Asheville started going to the public instead of inviting the public to them.


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Police Assist U.S. Marshals with Fugitive Arrest
14.03.2012 [Patch.com] - William Thomas O'Sullivan, 49, of 35 Davis St., was arrested on a warrant. At 11:19 am, police responded to Rainbow Avenue at North Road for a report of a woman walking in the street. At 11:39 am, police assisted US Marshals with an arrest.
Barber's success inspires launch of barber school
06.03.2012 [Reading Eagle] - George Ortiz Jr., owner of New Style Barber Studio, 1340 Lancaster Ave., gives former Philadelphia Eagles linebacker William Thomas a haircut in his shop. Ortiz is planning to open a barber academy with the receipt of a city microloan.
fotocommunity: William Thomas Mulvany
6 Pictures with 10 Comments, since 05/2009
fotocommunity: Thomas William
Ingersheim, 23 Pictures with 11 Comments, since 12/2005
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William Thomas Evans is credited as Performer.
Danielle Arci, William Thomas Evans, Felicia Finley, et al. Set for...
- Jun 14, 2011 by Brian Scott Lipton in Theater News.
William Thomas, OLB at NFL.com
William Thomas . Height: 6-2 Weight: 225 Age: 45 Born: 8/13/1968 Amarillo , TX College: Texas A&M
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No one in his low-key Brooklyn neighborhood would have guessed this father of four was allegedly a pimp responsible for running four brothels in Manhattan. Fort
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William Thomas, 6 Church Court, Richmond upon Thames - Hairdressers near Richmond Tube Station - All In London
Lieutenant William Thomas Dartnell | Australian War Memorial
William Dartnell, born at Collingwood, Melbourne, was only 15 years old when he enlisted for service in South Africa with the Victorian Mounted Rifles in 1901.
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Register @ Baseball-Reference.com · Players · Affiliates · Leagues · Leaders · Teams · Ballparks · Support us without the ads? Go Ad-Free! William Thomas ...
William Thomas Evans Theatre Credits
William Thomas Evans Theatre Credits - Broadway: Camelot; The Scarlet Pimpernel (occasionally the title role)versions 1 and 2 ;A Tale of Two Cities. National ...
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Until I put up my tree. I like to put it up the weekends after Halloween.
Until I put up my tree. I like to put it up the weekends after Halloween.
Wow, that's awesome! I can't put my tree up that early, because I get a real one. It would be dead by Christmas!
Less than 2 weeks for me as well
I have never put anything Christmassy up before Thanksgiving. Thats because I always have company for Thanksgiving and want to give that holiday its due. This year I may put up my new white tree before Thanksgiving! It will be out of the way - in the den - so won't be on display!
I'm Dreaming of a White Christmas
hello! im new to site/forum! but i wanted to say we are putting ours up early as well. november 12th they have a christmas parade in my city and we put our tree up that night the kids love it
I love Outdoor Christmas Lights!!


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Adorable and delightful set of two Soapcakes (designed after the popular Mooncake) in a variety of scrumptious fragrances.
Triple Coconut Care Formula. We've combined non-greasy, highly hydrating coconut oil, refreshing coconut water and deeply nourishing coconut milk for the ultimate in skin pleasure.
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We have no old photos of Allt y Bwbach available currently. However you can browse old photos of these nearby places:
Historic maps of Allt y Bwbach and the local area, hand-drawn by Ordnance Survey cartographers and Samuel Lewis.
Browse 6 photo books on Allt y Bwbach and the surrounding area.


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Item description for When Women Become Priests: The Catholic Women's Ordination Debate by Kelley Raab...While numerous provocative works have sought to justify why women should be ordained as Catholic priests, "When Women Become Priests" is the first sustained reflection on the differences that would obtain with women at the altar. In the face of a centuries-old tradition of a male priesthood, what are the implications for the Catholic church of ordaining women? Would women priests become co-opted into the male clerical caste, particularly in relation to celebrating the sacraments? In an analysis that deftly unites feminist criticism, psychoanalysis, and Catholic theology, Kelley A. Raab explores the symbolic implications of women at the altar, providing rich insight into issues of gender, symbolism, and power.
"When Women Become Priests" addresses critical issues about the effect of a female priest on the parishioners she would serve, on the sacrament of communion, and on the significance of the symbolism of Jesus that priest maintain during certain ceremonies. Rooted in her firm belief in the place of women within the Catholic priesthood, Raab's work is one that -- rather than reducing religious convictions to psychological construct -- seeks to re-invigorate these convictions for the contemporary world.
Supported by interviews with women in the Episcopal priesthood (which has ordained women since 1977), Raab draws upon object-relations theory, Freudian concepts of the unconscious, and French feminist thinkers Julia Kristeva and Luce Irigaray to show how the celebration of mass by women priests would require a constructive reenvisioning of core dimensions of Catholic theology.
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The Library is pleased to announce that we've added a new database to the library collection! It's called Writer's Reference Center.
The Writer's Reference Center database is contains essays and materials to support the writing process including: grammar, style, and research. It also contains reference books for writing topics such as: allusions, clichés, American regionalisms, words often confused, foreign words, literary terms, and more!


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Free Shipping & ReturnsBurberry Nail Polish - No. 100 Nude Beige
Burberry Beauty nail polish features a protective, long-lasting, high-gloss finish with accelerated drying and hardening times so you can get the gorgeous nails you want without having to wait for ages to let them dry. The formula contains strengthening and moisturizing elements, including vitamin B5 and myrrh extract to help protect and care for nails and prevent damage.How to use: The rounded brush design makes applying nail polish a breeze. Apply one to two coats. Nail polish will dry in under 2 minutes and will completely hardening within 6 and a half minutes. 100 nude beige, no. 101 nude pink, no. 102 english rose, no. 103 ash rose, no. 104 stone, no. 105 mink, no. 106 dark trench, no. 108 honey, no. 109 camel, no. 201 graphite, no. 202 metallic khaki, no. 203 storm grey, no. 204 khaki, no. 205 khaki green, no. 206 cadet green, no. 220 coral pink, no. 223 pink azalea, no. 299 poppy black, no. 300 military red, no. 301 poppy red, no. 302 polish red, no. 303 oxblood, no. 304 black cherry, no. 306 ruby glitter, no. 400 rose pink, no. 402 hydrangea pink, no. 405 dusty mauve, no. 407 elderberry, no. 410 pale grape, no. 414 bright coral red, no. 415 pale yellow, no. 416 daffodil, no. 418 aqua green, no. 420 sage green, no. 423 dark bottle green, no. 425 ink blue, no. 427 teal blue, no. 429 imperial blue, no. 431 stone blue, no. 440 optic white, no. 445 antique gold, no. 451 gold glitter, no. 453 silver glitter, no.200 steel grey. Brand: BURBERRY BEAUTY. Style Name:Burberry Beauty Nail Polish. Style Number: 35489. Available in stores.
Free Shipping & ReturnsBurberry The Kensington Mid Cotton-gabardine Trench Coat - Sand
Developed by Thomas Burberry in 1879, Burberry's signature cotton-gabardine is lightweight and breathable yet offers protection against inclement weather. Part of the 'Kensington' range, this mid-length trench is tailored with a fitted waist and slimline sleeves - what the brand calls the modern silhouette. Wear it with your favorite jeans and a sweater.
Free Shipping & ReturnsBurberry Nail Polish - Silver Glitter No.453
Inspired by the Fall '16 show, Burberry Beauty's polish is part of the limited edition 'Runway Nails' collection. It's packed with hundreds of flecks of silver glitter in a high-shine clear lacquer. Apply it as a light-catching top coat or wear it alone for a mirror-like finish. - Formulated with patent-pending technology- Contains antioxidant Pro-Vitamin B5 and Myrrh Extract to protect nails and prevent breakages -Instructions for use: - A high-precision rounded-end brush ensures easy application- A two coat layer dries in under two minutes - 8ml/ 0.27fl.oz.- Made in the UK
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A face-framing funnel collar adds elegant drama to a wool-blend trench softened with a whisper of cashmere and cinched with belts at the waist and cuffs. A hidden-button placket delivers a sleek effect, and logo-etched buttons at the epaulets, storm flap and pockets add understated branding. Brand: BURBERRY. Style Name:Burberry Gibbsmoore Funnel Collar Trench Coat. Style Number: 5195709. Available in stores.
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Burberry's black shell trench coat is lightweight, showerproof and comes with a detachable hood - perfect for changeable weather. It's detailed with the label's classic heritage features, such as buttoned epaulettes, storm flaps and a 'Haymarket' check lining. Use the belt to add definition to your waist.
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Fresh Glow BB Cream is the beauty balm that helps recreate the fresh, healthy-looking glow of a youthful complexion. Combining makeup and skincare benefits, the formula helps instantly minimize imperfections without hiding and moisturizes without weight. 01 fair, no. 02 medium, no. 03 dark. Brand: BURBERRY BEAUTY. Style Name:Burberry Beauty 'Fresh Glow' Bb Cream. Style Number: 734617. Available in stores.
Free Shipping & ReturnsBurberry Leather-trimmed Checked Canvas Hobo Bag - Brown
Burberry's hobo bag is an effortless way to integrate the label's signature check into your weekend wardrobe. This durable canvas style features a tan leather base and handles for added structure, as well as a detachable shoulder strap.
Free Delivery & FR: USAFREEBurberry Floral fil coupé silk crepe de Chine gown
Burberry Prorsum's red silk crepe de Chine gown is an elegant option for evening. Fresh from the AW16 runway it's cut to a slinky fit-and-flare shape with delicate details - note the front slit low-cut back and pretty metallic fil coupé florals. Snakeskin-print panels define the silhouette while topstitching nods to the label's military inspiration. Simply complete the look with black heels.
Free ShippingBurberry Sandringham Mid-Length Heritage Trench Coat
Cut from fine cotton gabardine and lined the house's signature check twill, the slim-fitting Sandringham features a fitted waist and narrow set-in sleeves. Notched collar. Epaulettes. Gunflap. Long sleeves. Belted cuffs. Double-breasted horn button front. Self belt. Side button pockets. Rainflap. Back vent. Signature check lining. About 34" from shoulder to hem. Cotton. Dry clean. Made in England.
Free Shipping & ReturnsBurberry The Kensington Long Cotton-gabardine Trench Coat - Beige
Burberry's long-length cotton-gabardine 'Kensington' trench coat has been meticulously crafted in England, going through 300 separate processes during production. This style has what the brand calls a modern silhouette - it is slim-fitting at the bust and waist but looser through the hip for easy layering. Knot the belt for added definition.
Free Delivery & FR: USAFREEBurberry Townhill wool and cashmere-blend pea coat
There's always a sense of refinement to Burberry Prorsum's outerwear. This midnight-blue Townhill pea coat is crafted from a warming blend of cashmere and wool and tailored to a classic silhouette with elegant fluted sleeves. The domed black buttons at the double-breasted front lend a modern finish. Layer it over one of this season's tie-neck blouses for a sophisticated result.
Free Shipping & ReturnsBurberry Women's 'Sandringham' Slim Trench Coat
Rich buffalo-horn buttons pop against the golden background of this signature Burberry London trench. A double-breasted placket, epaulets and belted cuffs add classic military-inspired style to the timeless silhouette, cut slim to flatter the feminine figure. Pop the convertible collar to flaunt a bit of House check. Brand: BURBERRY. Style Name:Burberry London 'sandringham' Slim Trench Coat. Style Number: 1014474. Available in stores.
Burberry Check Cotton Shirt Dress
A smart yet comfortable cotton shirt dress. In an iconic check pattern, the design references the signature details from our classic trench coat, from the epaulettes to the belted waist. Pair with heeled sandals for work or trainers on more casual days.
Up to 50% OffBurberry Leather And Checked Canvas Espadrille Sandals - Black
Burberry's sandals are set on jute platforms with gripped rubber soles. They're detailed with leather and cushioned canvas straps that showcase the brand's instantly recognizable heritage check. Wear yours with an oversized shirt and jeans.
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This taupe-brown Townley trench coat is woven from Burberry's iconic weatherproof cotton-gabardine and purposely washed for supreme softness. Shoulder epaulettes a bucked waist belt and adjustable cuff straps are classic touches while the structured ruffled collar and storm flap lend a flourish of femininity. Leave the top buttons unfastened to reveal the signature House-check lining.
Burberry Hooded Cotton Blend Parka with Detachable Warmer
A technical cotton blend parka with heritage-inspired epaulettes, cuff belts and check undercollar. Suited to protection against the elements, that design includes functionalities such as a detachable lightly padded warmer and drawstrings at the hem, waist and detachable hood. Finished with leather piping, it's a smart choice for colder days.
Free Shipping & ReturnsBurberry Balmoral Packaway Hooded Shell Trench Coat - Neutral
Coats and jackets can take up valuable room in suitcases, but not Burberry's lightweight trench. This taupe waterproof style is cut for a timeless, flattering fit and comes with a detachable hood. Wear yours with the accompanying belt for a defined, feminine silhouette.
Free Shipping & ReturnsBurberry The Sandringham Mid Cotton-gabardine Trench Coat - Beige
Burberry's trench coats are inspected approximately 26 times during construction. Expertly crafted from cotton-gabardine - a light yet durable fabric invented by Thomas Burberry in 1879 - this style is tailored for a slim fit through the body. It's finished with black leather trims, horn buttons and signature checked lining.
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Burberry's 'Tempsford' coat is cut from crimson cashmere in the brand's signature trench silhouette. This style has classic shoulder epaulettes and a waist-cinching belt. Pop the collar to reveal the iconic checked backing.
Up to 50% OffBurberry Denim Jacket - Mid denim
Though cut for a slim fit, Burberry's denim jacket nips in slightly at the waist to create a more feminine, flattering shape. This blue style has gilded embossed buttons, flap pockets and topstitched seams. Raise the collar to catch a glimpse of the iconic check print underneath.
Free Shipping & ReturnsBurberry Women's Check Merino Wool Scarf
Extra-fine merino wool lends unmistakable style to a lush scarf that's both lightweight and cozy. Brand: BURBERRY. Style Name:Burberry Check Merino Wool Scarf. Style Number: 594367. Available in stores.
Free Delivery & FR: USAFREEBurberry Sandringham long cashmere trench coat
Burberry re-imagines its iconic Sandringham trench coat in beautiful powder-pink cashmere for Resort 2017. It's crafted to the classic military-inspired silhouette with a double-breasted front and finished with storm flaps and a buckle-fastening waist belt. Flip the collar to showcase the tonal-grey house-checked underside.
Free Delivery & FR: USAFREEBurberry Minstead suede fringed wedge sandals
Burberry London's brown suede Minstead sandals offer a contemporary riff on the label's iconic house check. The vertiginous wedge heel is covered in the instantly recognisable pattern while the front straps are trimmed with fringing for a bohemian vibe. Style them with everything from distressed jeans to cotton shirtdresses.
Free Delivery & FR: USAFREEBurberry Leveson cashmere trench coat
Burberry London's Leveson trench coat is expertly crafted from light-grey cashmere ribbed-knit to a feminine and sophisticated silhouette. It's elevated with neat storm flaps and perfectly finished with a matching belt that's accented with metal D-rings. Effortlessly style it with your workwear staples.
Free Delivery & FR: USAFREEBurberry Maythorne mulberry-silk trench coat
This nude-beige silk Maythorne trench coat is a minimalist interpretation of an iconic Burberry design. It's cut to a loose-fitting shape with dropped shoulders and puffed sleeves and finished in signature style with buttoned epaulettes storm flaps and buckled straps. Slip it over a polished city edit to complete endless workweek looks.
Up to 50% OffBurberry The Sandringham Cashmere Trench Coat - Gray
Burberry reworks its iconic trench coat in Italian cashmere – prized for its warmth and exceptional softness. This elegant double-breasted design features all the traditional heritage details synonymous with the original, including buttoned epaulettes, a storm flap and D-ring hardware. Use the belt to cinch your waist.
Free 2-Day Shipping + FRBurberry Hodgeson Women's Slip on Shoes
Textile upper with patent leather accents. ; Watercolor print. ; Round jute covered cap toe. ; Leather and textile lining. ; Cushioned footbed. ; Burberry embossed accent at the side. ; Jute woven outsole. ; Made in Spain. ; This item may ship with an attached security tag. Merchandise returned without the original security tag attached or a damaged tag may not qualify for a refund. Measurements: ; Weight: 7 oz ; Product measurements were taken using size 38 (US Women's 8), width B - Medium. Please note that measurements may vary by size.
Burberry The Medium DK88 Top Handle Bag
Named after the house code for our signature honey-coloured gabardine, The DK88 is a tribute to the fabric at the heart of Burberry's history and is crafted in our exclusive new Trench Leather. Designed in England, the timeless silhouette reflects British sensibility through its classic and enduring shape and is defined by a structured top handle and a distinctive oversize lock. Carry it in the hand or over the shoulder using the crossbody strap.
Up to 50% OffBurberry Asymmetric Off-the-shoulder Cotton-blend Sweatshirt - Navy
Burberry's cotton-blend sweatshirt references the curved shapes seen in artist Henry Moore's iconic sculptures. It's cut with exaggerated sleeves and an asymmetric neckline that's designed to be worn elegantly off one shoulder. Wear yours with the brand's pants from the instantly shoppable February '17 runway collection.
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Burberry's sneakers are topped with a sizable gold buckle and midnight-blue strap in homage to the brand's iconic trench coat. They're crafted from clean white leather and have a contrasting navy patent heel tab. Wear them with jeans or dresses.
Free Delivery & FR: USAFREEBurberry Malthouse leather platfrom espadrille sandals
Use Burberry's brown calf-leather Malthouse espadrille sandals to ground crisp summer whites. They're crafted with tonal-brown and black crossover straps complete with perforated patterns and gold tone metal studs and set on a natural braided jute platform. Add drama with statement-making earrings and an embellished bag.
Up to 50% OffBurberry Pintucked Cotton-chambray Mini Dress - Mid denim
Burberry's 'Michelle' dress is an effortless choice for balmy evenings whether in the city or on vacation. Cut from blue cotton-chambray, this mini style is pintucked along the front and has fluttery bell sleeves - the brand's signature check peeks through as you move.
Up to 50% OffBurberry Buckled Stretch-crepe Mini Dress - Black
Burberry's streamlined dress is punctuated with a gold buckle that's reminiscent of those seen on the label's iconic trench coats. Cut from stretch-crepe in a shift silhouette, it's detailed with a lightly pleated split skirt. Accessorize yours with sandals and a clutch.
Free Shipping & ReturnsBurberry Canvas-trimmed Patent And Textured-leather Shoulder Bag - Black
Burberry's bag is perfect for nights out - the interior is outfitted with card slots and offers enough room for your cell phone and lipstick. This compact design is trimmed with patent-leather, heritage checked canvas and a polished buckle embellishment. Detach the chain strap to carry it as a clutch.
Up to 50% OffBurberry Printed Silk-georgette Dress - Green
Burberry's Spring '17 collection is inspired by Virginia Woolf's novel, Orlando . Lined for opacity, this dress is cut from floral-print silk-georgette in an A-line silhouette. Wear yours layered over a turtleneck top.
Free Shipping & ReturnsBurberry The Kensington Long Cotton-gabardine Trench Coat - Sand
Cut in the brand's modern silhouette, Burberry's 'Kensington' trench coat is inspected 26 times during production and is worked on by expert tailors. It's been crafted in Yorkshire, England from tightly woven cotton-gabardine that protects you against wind and rain. We love the 'House' check that decorates the undercollar and lining.
Burberry Medium Rucksack
This lightweight **Burberry** rucksack features cushioned and polished metal chain shoulder straps and leather trims. Inspired by the fabric of the Burberry trench coat the bag is crafted from a weatherproof nylon blend.
Free Shipping & ReturnsBurberry Women's Ashurst Quilted Jacket
A trim-fitting jacket exudes heritage polish with diamond quilting, shoulder epaulets and buffalo-horn buttons. An attached half-belt shapes the back waist and classic checks line the multi-season style. Brand: BURBERRY. Style Name:Burberry Ashurst Quilted Jacket. Style Number: 1099140. Available in stores.
Free Delivery & FR: USAFREEBurberry Point-collar cotton double-breasted cape
This khaki-green Burberry cape is a fresh take on the house's heritage-rich trench coat. The double-breasted front is designed to effortlessly drape over the body and punctuated with classic details such as the storm flap and epaulettes. Wear it to refine casual day looks.
Free Shipping & ReturnsBurberry Mini Leather-trimmed Checked Canvas Shoulder Bag - Brown
Burberry's canvas bag is woven in the brand's signature check. Trimmed with tan leather tassels, this mini design is sized to hold just the essentials and includes a small internal pouch that's perfect for storing cards, keys and coins. Adjust the shoulder strap to carry it cross-body.


text:
ED Magedson – Founder
Ripoff Report
Internet Cash MachineInternet United States of America
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
The telephone contact listed on the credit card statementstatedmy Mastercardcharge of$ 68.71was for a Biz Membership account that was not closed within 30 days. The person stated that she worked for a third party and was not authorized to provideinformation as to the name, address or person to contact relative to the Biz Membrership Charge. She also stated that she could close the account but that she was not authorized to issue a refund.Even though nowas received from this company.
This report was posted on Ripoff Report on 01/13/2011 08:12 PM and is a permanent record located here: http://www.ripoffreport.com/reports/internet-cash-machine/internet/internet-cash-machine-reward-zone-biz-membership-contact-advised-they-are-a-3rd-party-ca-682407. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
Click Here to read other Ripoff Reports on Internet Cash Machine
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In order to assure the best results in your search:
#1 Consumer Suggestion
SUBMITTED: Friday, January 14, 2011POSTED: Friday, January 14, 2011
Don't waste your time calling and speaking with idiots.
Just do a dispute for all unauthorized charges directly with your credit card company. Legally you have 60 days from the date the charge first appeared on a billing statement.
Call to initiate, and then they will send forms to you that you will need to complete. Send these back via certified mail, return reciept requested. Put the certified# on the form somewhere and keep a copy for your records.
Dispute for reason "Not authorized".
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#2 Author of original report
SUBMITTED: Thursday, January 13, 2011POSTED: Thursday, January 13, 2011
They charged me another $68.71 on December 20 in addition to the $ 68.71 they charged on November 20. All of this and I received nothing of value.
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MVD: leading
of CKCS deaths
Heart mitral valve disease (MVD) is a terminal illness which may afflict over half of all cavalier King Charles spaniels by the age of 5 years and nearly all Cavaliers by age 10 years. It is CKCSs' leading cause of death.
- More: Cavalier King Charles spaniel MVD
- Mitral valve disease breeding protocol
- A few words about pimobendan (Vetmedin)
- ACVIM cardiologists consensus statement
- Research news
- Find a cardiologist in the USA and Canada
The Latest in
Cavalier Health Research
& Upcoming Events
- May 2017 -- OUR BLOG: EPIC study's bluster about pimobendan unravels as critical analysis finally takes hold.
- May 2017 -- Cardiologist Mark Rishniw says "Not so fast!" in prescribing pimobendan to all heart-enlarged MVD dogs.
- May 2017 -- Dr. David Williams finds pain from corneal ulceration causes increased tear production and may mask dry eye.
- May 2017 -- Cardiologist Philip Fox claims EPIC Study makes echocardiography optional in prescribing pimobendan before heart failure.
- May 2017 -- Columbian researchers find a variation of gene COL1A2 may play a role in causing MVD in canines.
- May 2017 -- Detroit hospital physicians find Neladenoson may reverse hind leg weakness in dogs in heart failure.
- May 2017 -- Mayo Clinic engineers a designer natriuretic peptide to mediate kidney impairment by furosemide.
- May 2017 -- Synthetic BNP injections potentially can offset RAAS activation in dogs in CHF.
- May 2017 -- Nationwide insurance reports cavaliers and other brachycephalic breeds are more often affected by common health conditions.
- April 2017 -- Texas A&M cardiologists fine tune cardiac troponin I measurements of MVD progression.
- April 2017 -- Cavaliers are over-represented in UK survey of over-weight, less exercised dogs.
- April 2017 -- UK Kennel Club spokesman trashes the MVD Breeding Protocol.
- April 2017 -- Analysis of UK cavalier breeders' compliance with the MVD Breeding Protocol shows breeders' hypocrisy.
- April 2017 -- Inventors seek US patent for chronic pancreatitis drug camostat mesilate.
- April 2017 -- U. of Ga. pathologists find T-zone lymphoma in a cavalier King Charles spaniel.
- April 2017 -- CKCS with histiocytic sarcoma of his spleen has deceptive signs and pathology.
- April 2017 -- Brazilian researchers find a quality of life questionnaire can accurately predict approaching cardiac deaths of dogs.
- March 2017 -- Cummings School (Tufts) researchers need DM-affected dogs for an engineered adenovirus study.
- March 2017 -- Lung ultrasound exams can accurately diagnose early signs of pulmonary edema and may predict onset of congestive heart failure.
- March 2017 -- Slovenian researchers report correlations between NT-proBNP and CoQ10 concentrations in dogs receiving cardiac treatment.
- March 2017 -- Korean researchers find that serum homocysteine concentrations increase as MVD progresses in dogs.
- March 2017 -- Italian researchers find 70% raw beef diet bests dry kibble in producing healthy gut functions.
- March 2017 -- NEW TOPIC: Plants -- toxic, poisonous -- including the sago palm.
- March 2017 -- Thai researchers find long-term treatment of Stage B dogs with sildenafil (Viagra) prevented progression of MVD.
- March 2017 -- Japan's Masami Uechi reports 92% success rate in 600+ open heart surgeries for MVD.
- March 2017 -- OUR BLOG: Will general practice veterinarians cut corners to prematurely prescribe pimobendan to MVD-affected cavaliers?
- March 2017 -- Tricuspid valve replacement with cow or pig valves has significant complications.
- March 2017 -- 3-D echocardiograms show differences in shapes of mitral valves of MVD-affected dogs versus healthy dogs.
- February 2017 -- USA researchers find promising CSF biomaker for early diagnosis of degenerative myelopathy.
- February 2017 -- Austrian heart clinic offers mitral valve repair surgery on MVD-affected dogs in heart failure.
- February 2017 -- Serum proteins are found to be differentially expressed in cavaliers with MVD.
- February 2017 -- OUR BLOG: Does detecting heart failure in MVD-affected cavaliers matter anymore?
- February 2017 -- Japanese researchers find left atrium strain can predict heart failure in MVD-affected dogs.
- January 2017 -- Nutri-Plus Gel stimulates the appetite of a cavalier in Stage C mitral valve disease suffering severe weight loss.
- January 2017 -- Italian researchers find cavaliers as the main represented breed for nuclear glycogen inclusions in the stomach's gastric glands.
- January 2017 -- Dr. Borgarelli seeks cavaliers in heart failure for minimally invasive mitral valve repair.
- January 2017 -- UK study identifies characteristics that cause painful Chiari-like malformation and syringomyelia in cavaliers.
- January 2017 -- UK study uses MRI scan measurements of hindbrain and craniocervical junction angles and distances to compare Chihuahuas, Affenpinschers and cavaliers with and without syringomyelia.
- January 2017 -- Phenobarbital and potassium bromide are effective supplements to imepitoin treatment of idiopathic epilepsy.
- January 2017 -- N-terminal BNP predictions of MVD status get more complicated.
- January 2017 -- OUR BLOG: All that cavalier owners need to know about spironolactone.
- January 2017 -- UK Kennel Club reports 2013-2014 compliance rate with its CM/SM breeding protocol was 0.28%.
- January 2017 -- UK researchers rate successful medications for Episodic Falling Syndrome in CKCSs.
- January 2017 -- UK study of 8,860 cavaliers shows that MVD Breeding Protocol works but breeders' compliance was poor.
- December 2016 -- Whole genome, next generation sequencing detects new muscular dystrophy mutation in a cavalier.
- December 2016 -- Study shows healthy cavaliers' mitral valve structure differs markedly from other breeds.
- December 2016 -- OUR BLOG: Why do any veterinarians prescribe useless drugs to MVD-affected cavaliers before heart failure?
- December 2016 -- Tufts' researchers test mesenchymal stem cell (MSC) treatments to improve MVD-affected dogs in heart failure.
- December 2016 -- NEW PAGE: Anesthesia and Sedatives in the Cavalier King Charles Spaniel.
- December 2016 -- UK study finds that cavaliers' cardiac-caused syncope collapses have increased troponin concentrations.
- December 2016 -- Polish researchers find four cell markers signal left atrium enlargement in MVD-dogs.
- December 2016 -- NEW PAGE: Patent Ductus Arteriosus (PDA) and the Cavalier King Charles Spaniel.
- November 2016 -- NEW TOPIC: Inflammatory bowel disease (IBD) in the cavalier King Charles spaniel.
- November 2016 -- NEW TOPIC: Glaucoma in the cavalier King Charles spaniel.
- November 2016 -- Cavalier eye sizes are large for small dogs but fit in the medium dog group.
- November 2016 -- UK Kennel Club approves MVD testing scheme for cavaliers.
- November 2016 -- Cavaliers were 15+% of dogs with erosive immune-mediated polyarthritis (IMPA).
- November 2016 -- Electronic von Frey aesthesiometer (eVF) testing fails to distinguish pain levels in 70 cavaliers.
- November 2016 -- French study of 1,668 cavalier bitches shows birth, still-born, and post natal mortality rates.
- November 2016 -- Cavaliers with ventriculomegaly may also have normal pressure hydrocephalus.
- November 2016 -- To feed or not to feed the pancreatitis patient? Who knows?
- November 2016 -- Simon Swift calls for parents/ grandparents of UK show cavaliers to meet MVD breeding protocol -- only 4% of CKCSs have been meeting that protocol.
- November 2016 -- UK and US researchers investigate links between epilepsy, drug-resistance, and affective disorders.
- November 2016 -- Pig bladder grafts successfully return sight to two cavaliers with corneal ulcers.
- November 2016 -- Brazilian researchers use digital video imaging to determine eye blink rates in cavaliers.
Breeding policy would
end early-onset MVD
Veterinary specialists have designed breeding guidelines to eliminate early-onset mitral valve disease in cavalier King Charles spaniels.
RUPERT'S FUND pays for MRIs of older dogs, to aid the Syringomyelia Genome Research Project.
Rescue a Cavalier!
Donate to Cavalier Rescue USA
& Lucky Star Cavalier Rescue
Rescue Trust
Health Clinics
Updated Weekly
Over 100 Clinics Listed!
How to Find a Cavalier Breeder
Donate to the Cavalier Health Fund
Syringomyelia can cause
pain in cavaliers
Syringomyelia (SM) is reported to be "very widespread" in the cavalier King Charles spaniel breed. Syringomyelia is a disorder of the brain and spinal cord, which may cause severe head and neck pain and possible paralysis.
- More: CKCS syringomyelia
- SM breeding protocol
- Research news
- Reduced rate MRI clinic locations
- MRI screening protocol for SM
- Find a neurologist in the USA and Canada
- Use harnesses instead of leashes for CM/SM dogs
- Estimated Breeding Values (EBVs)
- "Pedigree Dogs Exposed"
- "Pedigree Dogs Exposed - Three Years On"
Hip dysplasia afflicts
up to 1 out of 4 CKCSs
Hip dysplasia reportedly afflicts up to one out of every four cavalier King Charles spaniels. It is a genetic disease which can cause the dogs pain and debilitation.
Low blood platelet counts are
not a problem for cavaliers
Low blood platelet counts in cavaliers usually are not a health problem. Many veterinarians are misled by low platelet counts to wrongly diagnose anemia or other serious disorders.
Brachycephalic Airway
Obstruction Syndrome (BAOS)
The size and shape of its head can cause serious breathing problems for the cavalier King Charles spaniel. Elongated soft palates, stenotic nares, everted laryngeal saccules, and laryngeal collapse are inherited developmental defects in the breed.
CKCSs are pre-disposed
to cerebellar strokes
Cavalier King Charles spaniels appear predisposed to develop cerebellar infarcts, or strokes.
Deafness is a double whammy for cavalier King Charles spaniels
Cavaliers are predisposed to a form of congenital deafness, which is present at birth, and also to a progressive hereditary hearing loss, which usually begins during puppyhood and worsens, or progresses, until the dog is completely deaf, usually between the ages of three and five years.
- How to Find a Cavalier Breeder in U.S.
- 10 Questions for Cavalier Breeders
- TOP TEN: Breeders Worst Excuses
- Genetic Eye Disorders in CKCS
- SM Healthful Breeding Protocol
- Progressive Deafness in Cavaliers
- Cerebellar Infarcts -- Brain Strokes
- Diabetes Requires Daily Treatment
- Masticatory Muscle Myositis (MMM)
- Fly Catchers: Biting Imaginary Flies
- Cavalier's Knees -- Patellar Luxation
- Cavaliers' Sudden Collapsing Explained
- Dry Eye Syndrome Means Constant Care
Campaign to Improve the Health of Pedigree Dogs
The Cavalier Tissue Collection Scheme
... to build a sustainable breeding program for the breed.


text:
Lengthy Church Services
Expand Messages
- Dear All,
As Pope Francis is going on making news these days, one of the recent headline was 'he shortened Holy Week Easter vigil service - short to the point'. He shortened the service!?
After reading this news, I was thinking about our Church services. Especially, the recent Good Friday service I attended.
In most of our Churches in the USA, Good Friday service starts at 9 AM and ends at 3PM or 4PM. This is 6-7 hours of service, excluding the kanji afterwards.
What is an ideal time for the church service? Does a Church service stretched more than three hours provide any spiritual value to the participants? Is it spiritually edifying for an average church goer?
In any Church, people with different time constraints and spiritual persuasions attend the public services. Are we respecting them or don't we care about their needs? Are we turning them off? Should we need open ended service, where participants have no clue when it ends? Or should we do our public services 'short to the point', as Pope did?
Without being judgemental, I was just curious to hear what you think.
~ Abraham Chirackal, Davenport, Iowa
- Some of our church members always complains that our service is lengthy. A normal Sunday service with sermon may be arround 2 1/2 hrs only. Most of the members skip the one hour prabhatha namaskaram and some may reach for last half our only. I like to point about a family who always complain about this long service. The aunty was not willing to sit for the marthamariyam samajam after the church. The uncle always cries about giving the nominal monthly collection for the church and skips the other charity collections. Now this family is a member of Heavenly Feast. Aunty goes for whole day Friday prayers even early to participate in the kanji and payar preparation. Uncle knows to pay the monthly deshamsham. Those who complain against the leangthy service, please rethink. Once you participate in holy Qurbana whole heartedly, you will not feel that it is lengthy. God save our church.
Regards, B V Chirathalattu, Vakathanam
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As genes help create enzymes that make antioxidants, break down toxins, error in those genes lowers the enzyme level or makes it overactive. This affects its pathway, causing chronic diseases (e.g., lack of certain digestive enzymes causes low nutrient absorption and deficiency). Find faulty DNA pathways in a salivary lab test. Confirm by checking organic acid level in urine via urine test. Take prescribed supplements.
Do you experience chronic symptoms that persist no matter what you do? Have you been diagnosed with a chronic degenerative disease such as Parkinson's or multiple sclerosis (MS)?
Gene Error Affects Enzyme Function
We all have genes within our DNA that provide instructions to make certain enzymes. These enzymes are crucial in carrying out vital physiological functions such as breaking down toxins or making antioxidants such as glutathione.
If there is an error with a gene (single nucleotide polymorphism or SNP), then the enzyme it was instructed to make will be deficient or perhaps overactive. Depending on that enzyme's job, that pathway will be faulty, leading to a myriad of downstream consequences.
A Few Examples
Not having enough of an antioxidant such as glutathione results in an increased risk for certain neurodegenerative diseases and cancer, not to mention a myriad of chronic symptoms. This is due to the buildup of certain toxins that are not being cleared appropriately. Not having enough of the enzyme that makes nitric oxide increases your risk of cardiovascular diseases.
One can also see how well a patient absorbs their nutrients. Perhaps you eat a great diet and still feel tired all the time or after meals. Certain pathways help you get energy from your food. If a particular digestive enzyme isn't working, you may continually be deficient in that nutrient despite eating foods high in that nutrient. For example, dry skin, hair, etc., are the signs of deficiency of good fats in the body, even though you supplement with fish oil, etc.
This can be very discouraging to a patient, not to mention all the money spent to overcome a nutrient deficiency, with minimal results.
Treatment And Cure
You can test your DNA for these SNPs in a simple salivary lab test. It is also recommended that you do a urine test to measure certain organic acids present in your urine. This can verify that the faulty pathways found in the DNA results are indeed expressing and causing consequences in the body (buildup of certain toxins). This will confirm to the doctor doing the interpretation that the patient needs a supplement to help correct the imbalance and scavenge the resulting toxins.
DNA mapping is becoming more widespread and is available directly to consumers. There are software programs for licensed professionals to not only interpret the DNA results but also guide the patient to the right supplements, custom made for the genetic pathways that have errors.
With these supplements, you can now reduce your risk for cardiovascular disease, certain neurodegenerative diseases, and cancer. You can influence the way you feel by getting the most out of your food and clearing the toxins from your system effectively.


text:
It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is noncompulsory but will drastically increase your chances of getting interest from other over 50s members on the site. Tell people about yourself, your pasttimes and upload your best photograph.
Use our website's cutting-edge search to pinpoint over 50s members who match your needs. Or just leaf through listings and pinpoint daters that arouse your interest.
Found someone who looks like a good match? Send them a message or just a wink and see how you get along. With a little luck you'll be on your way to uncover your perfect date.
It doesn't take long


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Jim Evans (umpire)
James Bremond Evans (born November 5, 1946, in Longview, Texas) is a former umpire in Major League Baseball who worked in the American League from 1971 to 1999.[1] He has operated the Jim Evans Academy of Professional Umpiring since 1990.
Evans began umpiring Little League games at age 14, where his playing experience as a catcher helped in judging balls and strikes.[2] Evans graduated from the University of Texas in 1968, and served in the National Guard.[3] He then worked as an umpire in college games and in the Florida State League.[2]
Evans attended the newly formed Umpire Development Program in 1969, and then worked in the Texas League (1969–70) and American Association (1971) before joining the AL staff in late 1971.[2] Evans became an AL crew chief in 1981. He wore uniform number 3 starting in 1980 when the AL adopted uniform numbers.
He umpired in 4 World Series (1977, 1982, 1986 and 1996), and in 7 American League Championship Series (1975, 1979, 1983, 1985, 1990, 1993 and 1998), tying a record set by Larry Barnett.[1][4]
Evans also umpired in the All-Star Game in 1976, 1989, and 1999, serving as the home plate umpire in the last two contests.[1] He worked in the American League Division Series in 1981, 1995 (Games 3-5) and 1996, and also in the single-game playoffs to determine the Eastern division champion in 1978 and the Western division champion in 1995.[1][5][6]
Evans is one of few umpires in history who have worked in two perfect games, having been the third base umpire for Mike Witt's perfect game on September 30, 1984, and the second base umpire for David Cone's perfect game on July 18, 1999.[7][8] Evans was also the home plate umpire for the first of Nolan Ryan's record 7 no-hitters on May 15, 1973, and worked behind the plate for Don Sutton's 300th victory on June 18, 1986.[2]
See also[edit]
- ^ a b c d "Jim Evans". Retrosheet.org. Retrieved 18 May 2012.
- ^ a b c d Grady, Jason. "Behind the Mask Q&A". baseballprospectus.com. Prospectus Entertainment Ventures, LLC. Retrieved 18 May 2012.
- ^ "Jim Evans". jimevanseurope.com. Retrieved 18 May 2012.[permanent dead link]
- ^ "Umpire records". mlb.com. MLB Advanced Media, L.P. Retrieved 18 May 2012.
- ^ "Retrosheet Boxscore: New York Yankees 5, Boston Red Sox 4". retrosheet.org. Retrieved 18 May 2012.
- ^ "Retrosheet Boxscore: Seattle Mariners 9, California Angels 1". retrosheet.org. Retrieved 18 May 2012.
- ^ "Retrosheet Boxscore: California Angels 1, Texas Rangers 0". retrosheet.org. Retrieved 18 May 2012.
- ^ "Retrosheet Boxscore: New York Yankees 6, Montreal Expos 0". retrosheet.org. Retrieved 18 May 2012.
External links[edit]
- Retrosheet
- BaseballLibrary.com - career highlights and list of articles
- Jim Evans Academy of Professional Umpiring - biography
- Baseball Prospectus - interview


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Are scrambled or hard boiled eggs easier to cook?
if you set a timer for them, hard boiled eggs are easier because you just pop it on the stove and let it sit. scrambled eggs are still easy and they prepare quicker but require more cleanup because...
Read More »
How long do you cook hard boiled eggs?
Bring water to a bail, add eggs, turn off water and let sit for 20 minutes. Yes, you can eat them right away.
How long should you cook 2 eggs for (hard boiled)?
everyone who said about ten mins. is right. also those who said put eggs in cold water let it boil and sit for ten mins. are right. aany shorter and you have a soft boiled egg. those who said 20min...
Read More »
How to Cook Hard Boiled Eggs in a Microwave Oven?
For years there has been a misconception doing the rounds that hard boiled eggs cannot be made by using a microwave oven. This wikiHow will show you just how you can make hard boiled eggs in this s...
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How to Cook Hard Boiled Eggs Without Cracking?
Do your eggs keep cracking when you try to hard boil them? Here are some tips to prevent that from happening. For a more general tutorial, read How to Hard Boil an Egg


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TyView in iTunes
To preview a song, mouse over the title and click Play. Open iTunes to buy and download music.
Mild-mannered British rapper Ty lacks the ragga flow and quick patois of most rappers from the Big Dada label; he's more the big brother, with clever, mature themes that commonly go far beyond the usual shot-callers involved in rap music. Born Ben Chijioke in London to Nigerian immigrants, Ty began recording during the mid-'90s, and appeared on tracks produced by IG Culture's New Sector Movement, MC Mell 'O', DJ Shortee Blitz, and DJ Pogo. He also hosted a hip-hop night called Lyrical Lounge, and worked with the Ghetto Grammar poetry workshop. His Ty debut came on Big Dada in late 2000 with the single "Break the Lock." His first full-length, Awkward, appeared early the following year and earned kudos from dozens of musical sources. His sophomore album, Upwards, dropped on Big Dada in late 2003 and received numerous end-of-year honors. An American release came the following spring. Closer, released in 2006, featured collaborations with heroes De La Soul and Arrested Development's Speech, while 2010's Special Kind of Fool -- his first release for BBE -- involved input from over a dozen guest vocalists. ~ John Bush
Top Albums
Top Songs
Birth Name:
Benedict Chijioke
17 August 1972 in London, England
Years Active:
'00s, '10s


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Famished, you eat into the fruit with abandon.
Too hungry to care about any possible danger, you bite into the unknown red fruit. The skin splits easily, and the sweet juices and pulp flood your mouth. How can something that tastes this good be dangerous? you think as you gather more of the fruits and wolf them down until you are sated.
When you are finally full, your long and sleepless night takes its toll. Making a better shelter will have to wait. For now, the ferns will again have to suffice. You have barely settled beneath their meager protection before sleep rolls over you like a dark wave with a froth of dreams on its crest.
After a timeless time, you slowly come to realize you are no longer alone in the dappled shade of the ferns. The warmth of another body lies against your side. Without opening your eyes you know, by scent and by touch, that it is Atai'aj who lies beside you.
"You cannot stay here. You must seek forgiveness in the Guldaj." When you start to protest, she lays her fingers across your lips to silence you. "The covenant is broken and there must be foregiveness. The breaking of the covenant bears with it a curse. With forgiveness, I will bear you a son and he will be chief. When you return, your place here will be one of honor. Fail, and he will not live a year. Nor will you."
"Why not just stay here? There's food, water, and we can build a shelter. You can have our son here, and we will raise him. Why follow me here unless this is what you wanted?"
"But I'm not here. Open your eyes and you will see."
Opening your eyes is surprisingly hard, as if the lids are weighted. With a great effort, you force your eyes to open at last.
Morning has passed into afternoon as you slept. There is no sign of Atai'aj, no hint that she was ever there.
You grasp at the already-fading memory of the dream, but it is gone. All that remains of it is a new sense of need to find the peaks of Guldaj.


text:
"I will try to express myself in some mode of life or art as freely as I can and as wholly as I can, using for my defense the only arms I allow myself to use -- silence, exile, and cunning." -- James Joyce
Chaos Theory Now Online!
That's right kids, for those of you who just shelled out $6 (+$2 s&h), if only you'd waited... The critically acclaimed Chaos Theory is now available online. Now just how would Gene and Wabulon have repelled a Panzer division armed only with their sarcasm and liquor breath? Find out this and so much more!
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Italian Inflation Rises To 0.2% In August
RTTNews - Italian consumer prices including tobacco rose 0.2% year-on-year in August after posting zero growth in July, a preliminary report from the statistical office Istat showed Monday. Economists had expected the consumer price index or CPI to rise 0.1%.
On a monthly basis, the CPI climbed 0.4% in August versus 0.0% growth in July, while it was forecast to rise 0.2%.
The harmonized index of consumer prices or HICP rose 0.3% on a monthly basis and grew 0.2% on an annual basis.
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