text:
New York Medical College, Valhalla, NY
PURPOSE: To investigate in patients undergoing coronary angiography for suspected coronary artery disease (CAD) the association of 3-vessel obstructive CAD with severe or moderate decrease of glomerular filtration rate (GFR).
METHODS: In a prospective study, 1007 patients had coronary angiography performed. The patients included 672 men and 335 women, mean age 66 ± 8 years. Obstructive CAD was diagnosed if the patient had >50% narrowing of at least 1 coronary artery. Glomerular filtration rate (GFR) was calculated prior to coronary angiography using the Modification of Diet in Renal Disease equation. Severe renal insufficiency (RI)was diagnosed if the GFR was <30 ml/min/1.73 m2. Moderate RI was diagnosed if the GFR was 30-59 ml/min/1.73 m2. Mild or no RI was diagnosed if the GFR was 60 ml/min/1.73 m2 or higher. Age, gender, race, smoking, hypertension, and hypercholesterolemia were similar in patients with moderate or severe decrease in GFR versus mild or no decrease in GFR. Diabetes was present in 112 of 259 patients (43%) with moderate or severe decrease in GFR versus 206 of 748 patients (28%) with no or mild decrease in GFR (p<0.001).
RESULTS: Obstructive CAD was present in 225 of 259 patients (87%) with moderate or severe decrease in GFR versus 533 of 748 patients (71%) with mild or no decrease in GFR (p<0.001). 3-vessel obstructive CAD was present in 138 of 259 patients (53%) with moderate or severe GFR decrease and in 170 of 748 patients (23%) with mild or no GFR decrease (p<0.001). Logistic regression analysis showed that patients with moderate or severe GFR decrease had a 4.1 times higher risk of developing 3-vessel CAD after controlling the effect of diabetes than patients with mild or no GFR decrease (relative risk = 4.1; 95% CI, 3.0, 5.5).
CONCLUSION: Moderate or severe reduction in GFR is a significant risk factor for obstructive CAD and for obstructive 3-vessel CAD.
CLINICAL IMPLICATIONS: Patients with moderate or severe reduction in GFR should have intensive modification of coronary risk factors.
DISCLOSURE: Omar Khalique, No Financial Disclosure Information; No Product/Research Disclosure Information
Tuesday, October 23, 2007
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Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.


text:
Ship to
Wireless RF (radio frequency) 2.4GHz
Operation distance: 10 meters ( 32.8 feet )
Power conservation mode during times of no movement
PC USB connector
Compatible with Windows 2000/XP/VISTA
With slim link office keyboard
Built-in trackball for optical mouse or outfit single slim optical mouse
Tracking ball resulution: 800DPI
Powerful office function 78 keys and 35 hotkeys
Optical frequency: 2.4Ghz radio frequency
Operating current : keyboard: 8mA max, receiver: 30mA max
FN: Num local change function
Powered by 2 AAA batteries (included)
Color: Black
Dimension: 272 x 110 x 25mm(LxWxT)
Net Weight::431g
Shipping Methods:
When you order from TOMTOP.com, you will receive a confirmation email. Once your order is shipped, you will be emailed with the tracking information for your order's shipment. You can choose your preferred shipping method on the Order Information page during the checkout process. TOMTOP.com offers different shipping methods for you:
|Shipping from Chinese Warehouse:
|Shipping Type
|Shipping Time
|Airmail and register airmail
|United States,Canada
|10-20 business days
|Australia, New Zealand, Singapore
|15-25 business days
United Kingdom, France, Spain, Germany, Netherlands, Japan, Belgium,
Denmark, Finland, Ireland, Norway, Portugal, Sweden, Switzerland
|20-30 business days
|Brazil and Mexico
|20-35 business days
|20-35 business days
|Other countries
|10-25 business days
|Singapore & China (EMS)
|All countries except those listed below
|6-10 business days
|Brazil and Russia
|10-25 business days
|Expedited Shipping(DHL)
|3-7 business days
|Shipping from Local Warehouses:
|Shipping Type
|Shipping Time
|UK Warehouse
|Royal mail without tracking number
|5-12 business days
|Can be delivered to UK & other EU countries.
|3-7 business days
|USA Warehouse
|Air mail with tracking number
|5-12 business days
|Can only be delivered to America.
|3-7 business days
|DE Warehouse
|3-8 business days
Can be delivered to worldwide. (But its shipping cost varies from
different countries. Recommend to choose if you are in Europe.)
The transit time depends on where you're located and where your package comes from. If you want to know more information, please contact our customer service. We will settle your problem as soon as possible. Enjoy shopping!
Payment Methods:
TOMTOP.com accepts PayPal, Credit Card, Western Union, Wire Transfer, QIWI and Yandex as secure payment methods:
1. PayPal
1) Login To Your Account or use Credit Card Express.
2) Enter your Card Details, the order will be shipped to your PayPal address. And click "Submit".
3) Your Payment will be processed and a receipt will be sent to your email inbox.
2. Credit Card
1) Choose your shipping address OR create a new one.
2) Enter your Card Details and click "Submit".
3) Your Payment will be processed and a receipt will be sent to your email inbox.
3. Wire Transfer
For orders more than $500, please contact us and provide us with the following information: your order number, the total amount paid, and the exact date of the wire transfer.
4. Yandex
Вы можете заплатить из кошелька в Яндекс.Деньгах или с привязаннойк нему карты. Комиссии нет.
1) Выберите страну, где был открыт ваш счет
2) Введите номер вашего QIWI кошелька
3) Введите номер, ваш пароль и нажмите на кнопку оплаты
4) Нажмите на "оплатить с QIWI", Вы будете перенаправлены на страницу с деталями платежа через QIWI
5) Введите номер ваш пароль и нажмите на кнопку оплаты
6) Ваш платеж будет обработан
7) Вы будете направлены на страницу с деталями заказа для подтверждения
Вы будете перенаправлены на сайт QIWI, чтобы произвести оплату с вашего QIWI Wallet.
1.Does TOMTOP check the products before shipping them to me?
Yes, for sure.
We have a professional Quality Control team. They will check carefully for each item we received from suppliers and manufacturers to avoid sending defective goods to our customers.
If a item is found defective in our QC test, it will be returned to the supplier / factory. So please don't worry about receiving a defective item because we are committed to being a trustworthy and reliable seller on international on-line shopping market.
2.Are Products Guaranteed / Is There A Warranty?
Yes, everything you buy from TOMTOP has a guarantee of quality and will exactly match the description on the website.
Factories that supply TOMTOP are strictly evaluated by us, and we provide you an even better reassurance of consistent high quality thanks to our in-house QC team. We double-check the contents of all orders carefully before dispatch to our customers. You can be confident about ordering from TOMTOP just as much as any western retailer.
3. How long dose it take to have my orders shipped after the payment is made?
1.Processing time 1-2 business days normally: During this period, we do strict quality-control tests and get the items carefully packed.
2.Sometimes the item in your order is really a hot seller and it may be just sold out at that time. It will take us 1-2 more days to get it available in stock again. In this case, The processing time will be 3 business days.
If you don't receive any shipping confirming over three days after the payment is made, please kindly contact our customer service . They will check for you.
4. What should I do if my items arrived damaged?
Rarely, rough handling by the courier can lead to physical damage to your goods, e.g. broken screen.
If this has happened, please follow these steps:
If possible, raise a complaint directly with the delivery representative of the courier company before you sign for the goods. They will advise you on the complaint procedure.
If you already signed for the packet, take photos showing the damage and contact the local office of the courier/delivery company to complain. They will have a complaining procedure which will enable you to get compensation.
Next, contact TOMTOP immediately with your order number and a full description / pictures of the broken item issue. We will contact the courier company from our end.
Once the courier company confirms that the case is valid, they will compensate TOMTOP, and we will pass on this compensation to you. The compensation varies from case to case and is different for each delivery company. In some cases you will need to pay to post the broken item back to TOMTOP in order for us to send out a new piece.
5. What should I do if my products go broken after a period of use?
If you encounter quality issues within the warranty period, you can ask for us. Every product has a specific warranty period(If it is not stated in the product listing, contact us).
In this case, please kindly provide us with proof as below:
The photos of original TOMTOP package with front and back sides
The photos or video of the defective item(s)
The photos, video or screenshot showing the malfunction of the defective item(s)
We will usually offer you a refund or send a replacement as soon as the problem is confirmed.
Sometimes you may need to ship the defective item back to us for free repair service or a new replacement. Customer should cover the return shipping fee, and TOMTOP is responsible for the shipping costs of arranging reshipment by air mail.
Monday to Friday, 09:00 AM - 06:00 PM, (UTM+8)
Monday to Friday, 09:00 AM - 06:00 PM, (UTM+8)
Question & Answer
Average Rating:
based on 3 Customer Reviews
Share your thoughts with other customers and get Tomtop Points, the first 5 reviews get DOUBLE Tomtop Points!Write a Customer Review
By s***2 March 29, 2012
Pros: This Wireless Office Mini keyboard looks quite well. And it can turn to conservation mode if I stop using it for a period without turning it off. the tracking ball is quite good. Cons:The receiver is sometimes not responsive. Bottomline:This Wireless Office Mini keyboard works quite well for me.
By 2***8 October 27, 2010
Pros:It came very well packaged. I was intending to use it on my bed, and a regular mouse is not an option for that. So it works exactly how I intended. The wireless range is good for my use. The built quality is surprisingly good. The keyboard is very light and slim. I simply loved it. Cons:The touchpad sometimes seems to be less responsive but it works fine. I just use it to open some video file or something that I am unable to do just with the keys. Bottomline:Very nice keyboard, I am very pleased. From Brazil.
By h***e August 26, 2010
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subset: commoncrawl


text:
Cloud Microphones Cloudlifter CL-1 Mic Activator
1-Channel Level Amplifier
- +25 dB for dynamic or passive ribbon microphones
- To be used in conjunction with a microphone amplifier with standard phantom power on mixers/preamplifiers/audio interfaces with mic input
- Requires phantom power
- XLR input and output
- Metal casing
- Band for fixing to microphone stand included
Customers that were interested in Cloud Microphones Cloudlifter CL-1 Mic Activator, have then bought these products
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text:
The 4k advantage was a little less obvious with the Sintel animation than it was with the Italian time lapse footage, partly because of the amount of PC-induced screen tearing the trailer suffered with, and partly because there's inevitably less chance for 4k detailing to 'shine' on a rendered animation. But there are some closeups of two characters towards the end which reveal an astonishing amount of texture mapping and clarity in their hair and clothing.
Almost unbelievably good though real 4K looks on the VW1000ES, real 4K content is currently going to take up precious little of your viewing time for the forseeable future. So we're fascinated to see how the projector's 4k upscaling system shapes up.
Upscaling wonder
Thankfully - crucially, in fact - it shapes up exceedingly well. During previews of the VW1000ES we'd seen obvious unwelcome processing side effects, but these have been almost completely abolished on the finished product. So if you engage the Reality Creation system while watching a Blu-ray, the VW1000ES now adds bags of extra detail, texture and clarity without generating seemingly any unwanted side effects such as motion 'haloes', colour striping or unnatural levels of grain or dot crawl. The mind boggles at just how much power Sony has had to throw at its upscaling engine to deliver such high quality results given how many pixels are involved.
It's important to stress that the impact the upscaling has on Blu-rays is so strong that it can clearly be seen from a normal viewing distance; you don't just have to have your nose stuck up against the screen again to appreciate the projector's 4k efforts.
This upscaling talent is, of course, crucial if the VW1000ES is to justify its price ahead of more true 4K sources arriving, given that its price pitches it against full HD projectors from the likes of Sim2 and Runco.
Excellent colour response
With these rival machines in mind, along with, inevitably, JVC's 4k 'e-shift' X70 and X90 D-ILA models, we need to shift our focus away from simply ogling the VW1000ES's astounding fine detail and sharpness. Looking at its colour response, though, it holds its own very nicely thanks to both the vibrancy of its tones and the almost infinite subtlety of its blends - driven by onboard 12-bit processing.
The VW1000ES's pictures are reasonably bright, too. Not as bright as Sim2's (30 grand!) Lumis or £16k Nero 2 models, but markedly brighter than JVC's projectors and bright enough to look punchier and more dynamic than mainstream projectors or any previous Sony SXRD models.
Given how bright it is, we were also very impressed by how quietly the VW1000ES runs, even when using its lamp on High for 3D viewing.
3D excellence
Talking of 3D, this is another area where the VW1000ES (comfortably) outguns JVC's models. For as well as its 3D pictures looking notably brighter, they also suffer much less from crosstalk ghosting noise. In fact, we struggled to see any crosstalk at all.
Sim2's Lumis 3D and Nero projectors deliver a bit more brightness with their 3D images than the VW1000ES does, but nonetheless Sony's 3D efforts can be considered outstanding.
There are only two areas where the VW1000ES comes second to both Sim2 and JVC projectors. First, its upscaling engine, while outstanding with Blu-rays, can struggle with standard definition sources - as might be expected, really, given how much new picture information is having to be calculated.
Second, intensely dark sequences like the one where Lord Voldemort and his army look down on Hogwarts from a hillside show a little grey clouding over parts of the picture that should look black - a slight black level shortcoming that can also lead to such images also losing some shadow detail.
Hot on the heels of its spectacular success with its 46HX853 TV, Sony has struck again with the VW1000ES. This is a genuinely groundbreaking projector which, even with its minor black level issues, remains a scintillating performer.
Especially as, of course, it introduces us to the emphatic joys of 4k. Yes, these ultra-high definition pictures look at their mind-blowing best when your source is a native 4k one. But with such sources not likely to be widespread for years, perhaps the single most important thing about the VW1000ES is that its 4K upscaling also makes Blu-rays look better than normal. So its 4k talents don't just have to sit there unused until Hollywood finally gets its home 4k2k act together.
Isn't the idea of 4K images a bit silly considering the size of the screen one would need to see the added detail provided by the increased resolution? For example, I sit about 10 feet away from a 92" projection screen, which is supposed to allow me to see the added detail provided by 1080p content. For a 4K image, I'd probably have to sit about 5" away from the same sized screen. Either that, or I'd have to go to a 150" screen and sit 10' away. How many people will want to do this in their homes? Maybe I'm missing something...
I agree with Dr Maustus. The article doesn't mention the screen size, distance it was viewed from or the throw ratio. I think glasses-less 3D will be more important than 4k. Is it possible to have glasses-less 3D with a projector?
Your comments system is awful.
Why do you moderate posts if you're going to publish something like my comment above without response? The problem I am having is any comment more than a few lines just hangs at the submit stage. You need to sort this out - it's pretty poor from a professional editorial site, especially one dedicated to tech. I am on IE 8 on Win 7 by the way.
Hi John, I guess there was no reply as there was little to reply to. I haven't heard of this problem before. Are you saying shorter comments post okay? How long is too long? Is it intermittent? Have you tried other browsers? Cheers, Ed
You do have a fairly large source of 4k content...PC games!
Ok you'll need a hell of a PC to power some games at the res, but still!
Mozzila Firefox on PinguyOS
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text:
Re: generating the TLS cert
Expand Messages
- On 01/03/2013 10:10 PM, Viktor Dukhovni wrote:
> On Thu, Jan 03, 2013 at 11:05:42AM -0500, Robert Moskowitz wrote:It was a warning. More likely it would be the clients that would
>> An update on creating self-signed certs.
>> On 12/20/2012 09:32 AM, Viktor Dukhovni wrote:
>>> On Thu, Dec 20, 2012 at 02:15:35PM +0000, Viktor Dukhovni wrote:
>>>> People who want a more compact recipe for a self-signed cert on
>>>> a single SMTP server can use my "one-liner" (for machines whose
>>>> hostname is an FQDN):
>>>> $ tmp=$(mktemp smtpd.pem.XXXXXX) &&
>>>> openssl req -new \
>>>> -newkey rsa:1280 -keyout /dev/stdout \
>>>> -x509 -days $((365 * 10)) -subj "/CN=$(uname -n)" >> "$tmp" &&
>>>> mv "$tmp" smtpd.pem
>>> With the "-nodes" option in most cases:
>>> $ tmp=$(mktemp smtpd.pem.XXXXXX) &&
>>> openssl req -new \
>>> -newkey rsa:1280 -nodes -keyout /dev/stdout \
>>> -x509 -days $((365 * 10)) -subj "/CN=$(uname -n)" >> "$tmp" &&
>>> mv "$tmp" smtpd.pem
>> I was noticing an error in /var/log/httpd/ssl_error_log about the
>> cert having basicConstraints: CA=TRUE
> If some HTTP server does not like self-signed SSL certs with CA=TRUE,
> that's its own problem. Postfix will not force you to jump through
> such pointless hoops.
object. Postfix may be happy with such a cert, but some other MTA or
client might not accept such a cert from Postfix.
One of the IETF mantras is "be conservative in what you send and liberal
in what you accept". So a client SHOULD accept this, but not MUST
accept it. A server MAY send it, but SHOULD avoid it.
So I was just sharing my experience in working with the cert and what
warnings I have been getting that are, based on the standards, correct
But I think this is a pernicious problem as the localhost.crt created
during firstboot on my Centos 6.3 system has CA=TRUE. I need to look
into this more before I submit a bug report upstream to Redhat.
- On Fri, Jan 04, 2013 at 12:30:50PM -0500, Robert Moskowitz wrote:
> >There is nothing wrong with "CA:true" in a self-signed SSL certificate.What meetings you happened to attend is of no consequence.
> By some definitions of 'wrong' :)
> You may not have attended the same sort of PKI policy meetings that
> I lived through! But since this is in large measure a policy issue,
> we will leave it there.
> I will test with user_cert over v3_req that I learned about over onIt is "usr_cert", not "user_cert". The difference in the resulting
> the OpenSSL list. See how they compare.
extensions is:
X509v3 Basic Constraints:
X509v3 Key Usage:
Digital Signature, Non Repudiation, Key Encipherment
X509v3 Basic Constraints:
Netscape Comment:
OpenSSL Generated Certificate
X509v3 Subject Key Identifier:
X509v3 Authority Key Identifier:
default (v3_ca):
X509v3 Subject Key Identifier:
X509v3 Authority Key Identifier:
X509v3 Basic Constraints:
Perhaps of the three "v3_req" is the closest to a sensible set of
extensions for an endpoint certificate.
Your message has been successfully submitted and would be delivered to recipients shortly.


text:
The Zendesk family of products work together to help you improve customer relationships
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text:
CHERYL Cole is planning her first face-to-face meeting with Simon Cowell since
she was sacked from US X Factor.
It has taken months for the singer and music mogul to get speaking again after
Cheryl was ditched from the show in May.
And although they're on talking terms, they haven't seen each other since.
A source said: "It had been pretty frosty for a while but Cheryl has mellowed
and they've turned a corner.
"Simon has always wanted to remain friends with her but it's understandable
how she needed time to calm down. Now they're on talking terms and banter is
in full swing, they're discussing a meet, which is likely to be in LA."
The least he can do is buy lunch.


text:
Part 85961pb01
31,030pages onAdd New Page
this wiki
this wiki
Brickipedia is currently undergoing a change with the naming of part articles and this article's name may be outdated.
This article should be brickified to fit within the style of Brickipedia.
|Design ID: x190
|Years in production: 2008
| Available Colours:
Part 85961pb01 is the Agents breastplate.


text:
Food & Wine
2013 Duckhorn Vineyards Napa Valley Merlot
Petrossian Sliced Smoked Salmon
The Cook's Illustrated Cookbook
Los Angeles
by David Latt
La Sandia Mexican Kitchen and Tequila Bar shares the top floor of Santa Monica Place with half a dozen other restaurants, the Food Court and the Market.
You'll recognize La Sandia by the crowded...
Los Angeles
by Anna Harari
Three weeks into all night shoots in Chatsworth on a low-budget indie movie with the same caterer twice a day serving us burgers for "breakfast" every single day (not even I can eat a burger...Read more...
by Kitty Kaufman
Seiyo Sushi & Wine Shop in Boston's South End on Washington Street has a patio where you can eat as well as watch ambulances shrieking their way to Boston City Hospital but all in a good way. Our...Read more...
by Lisa Dinsmore
For the past decade, my husband and I seem to find ourselves in Scottsdale Arizona every Spring. Most years it's to celebrate the arrival of another baseball season by talking in as many...Read more...


text:
It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is up to you but will seriously increase your chances of your profile being viewed by others. Type a little about yourself, your interests and upload your best photograph.
Use our website's sophisticated search to pinpoint members who match your desired requirements. Or just browse through listings and pinpoint people that arouse your interest.
Identified someone who looks suitable? Send them a word or two or just a wink and see if they're interested. With a little luck you'll be on your way to locating your soulmate.
It only takes a few minutes


text:
You are currently using an unsupported web browser.
We support the latest versions of these browsers:
If you have any problems while attempting to download a browser, you should contact your organization's system administrator.
For any questions related to Cvent, feel free to contact our Customer Care team.
The JUFA Sigmundsberg is situated near Mariazell and is set in picturesque surroundings below a small chapel in the very heart of the unspoiled natural environment. There are impressive views of the Mariazell Basilica 3 kilometres away.
The large sports field provides a safe envi...
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text:
CHRIS HUGHTON admits Norwich are already fighting to beat the drop after failing to win any of their opening seven league games.
The Canaries confounded the critics with a comfortable mid-table finish in their first season back in the top flight.
But it may not be quite so easy this time as they continue to leak goals at an alarming rate. Hughton said: "We shot ourselves in the foot by conceding poor goals and that's always a recipe for disaster against a team of Chelsea's quality.
"For a club like Norwich, the season is always about making sure we retain our Premier League status. We're seven games without a win but there is an awful lot of football still to be played."


text:
1896 House - Barnside Inn
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this b&b rated in the past?
- Restaurant
- Continental Breakfast
- Swimming pool
- Free parking
Photos of 1896 House - Barnside Inn
Travelers also looked at:
- Restaurant
- Swimming pool
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TripAdvisor Reviews 1896 House - Barnside Inn Williamstown
Travel Blogs from Williamstown
Exploring the Berkshires in Massachusetts
As we crossed over into the State of Massachusetts, (ok, from here forth it's going to be referred to as Massa as it's too long a word to keep writing and I'm bound to mis-spell it at some point!)
So as we crossed over into Massa, most things remained the same, the rolling hills, the pretty houses and the winding country roads.
The only obvious change was the re-introduction to ...
Van Gogh and Nature
... those times when you go for it because this confluence of paintings all in one place may never happen again. This Van Gogh and Nature exhibit features nearly fifty paintings and drawings from thirty museums and private collections around the world. And Van Gogh is one of my most favorite artists! So how could we not go!
No photography was allowed – but interesting enough is that if you want to ...
Mechanicville stop
... diesel at a tank outside- we will bring our gerry cans since it's not too far from the wall. Mechanicville is a convenient stop- you don't even really leave the channel you just push off a bit to the side and onto the wall. There is a lot of wake from passing boats but luckily for us there has not been much traffic at all and the locks close at 6 pm anyway. There looks to be an Italian restaurant or two ...
Back Roads to Albany
... It is a quaint little town with refurbished buildings and beautiful flowers in urns and borders. We stopped for a few minutes to stretch and I walked through several of the shops. I was surprised at the number of ladies, mainly ladies, shopping the area. We continued through the hills of the Vermont countryside to Albany. It was a good ...
Our time in Vermont
... bring some samples home with us. While downtown Saint Johns is nothing to write home about, the surrounding areas are really beautiful. Rolling hills and beautiful lush/green scenery. We were happy when Josh & Jamie came to spend a day/night with us. We really enjoyed their visit.
8/12-8/15....Not that far away from St. Johns we headed to Thetford, VT. The ride down was pleasant and again, beautiful landscapes all along ...


text:
ED Magedson – Founder
Ripoff Report
Auto Gallery of Springfield, Missouri1579 US Hwy 60 E Republic, Missouri United States of America
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A secret stash of research papers has been uncovered that gives new hope to families fighting for compensation after they claimed a pregnancy test resulted in their children being born with deformed limbs.
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One of my favorite sites, creditboards.com, is great for a lot of reasons. That's why I contribute in the forum all the time. I'm giving back to a place where I have taken so much. It's called paying it forward. But another reason I hang out there is so that I can keep my finger on the pulse of the credit landscape. What I've noticed during the past two days is that American Express is wielding its sickle with a lot more frequency now. It seems to be stepping up its campaign of exposure reduction aka lowering limits.There are at least five threads at the creditboards forum that illustrate my point see the threads here, here, here, here, and here. A couple of the people who have suffered adverse action in the past 24 hours are, what I would imagine, very low-risk customers. Doesn't matter, apparently. American Express is taking a knife to these limits. Also, make no mistake. I am referring to American Express cards that are underwritten by the American Express Centurion Bank. This column is not applicable to American Express-branded cards that are underwritten by banks such as Citibank, Bank of America, HSBC, USAA, etc.Users at creditboards aren't the only ones suffering adverse action, either. A lady who was interviewed by the Los Angeles Times saw her $30,000 limit card cut to $1,000. See story here. A quick search on Google will likely turn up other stories as well. There is also a thread at creditboards.com regarding a RUMOR that American Express may be getting out of the credit card business as opposed to the charge card biz. I don't know where this information is coming from, so I cannot give the rumor any credence. Could be a poster simply trying to scare people for all I know. Update: the poster said this about the rumor: 'A friend of mine from California works at a bank and that is what they talked about at the water cooler…it is just a RUMOR.'Notwithstanding that rumor, it would not shock me if Amex was getting out of the credit card business though it's unlikely. American Express has its roots in the charge-card biz. Amex seems to have a real disdain for customers who carry a balance on credit cards that can be revolved each month. As I've said before, if American Express wants these people to pay in full each month, why is it even in the CREDIT card business?A couple of months ago, when I applied for my Amex card, I wrote a very lengthy article about my game plan for American Express link here. After the last couple of days, I'm convinced that my rationale for getting a charge card instead of a credit card was spot on. American Express, at the end of the day, seems to be struggling with its decision to be a credit-card company in addition to being a charge-card company. Most of the slashing during the past 24-48 hours has centered around credit cards though I have seen some charge cards get their exposure limits reduced as well. By and large, though, I think that American Express — for now — is going after credit card customers first no proof, it's just my hunch. After that, maybe they make a run at charge-card customers. I'll keep saying this until I am blue in the face: diversify, diversify, diversify. You never know when a creditor will start taking a torch to credit limits. Have backups to your other creditors.We're living during a very uncertain time right now. People are on edge. I imagine these latest American Express moves are not helping things.Related Articles:American Express to Cut 7,000 JobsAmerican Express Customers: Don't Try This At HomeAmerican Express Rates Credit Risk By Where You Live, ShopAmerican Express — The Game PlanAre Your Shopping Choices Hampering Your Ability to get Credit Line Increases?American Express's Financial Review System is Flawed, But I Respect Its Right To Request A Financial Snapshot From Time to Time
American Consumers Are More Likely Than Ever To Default On Loans, Bills, Study Finds
Mary Pilon, who holds down the fort at The Wallet, takes a look at data that were released by TransUnion today. According to the Credit Risk Index, which TransUnion created about a decade ago, extending credit to American consumers is nearly 25% more risky than it was just ten years ago. From the Wallet:Lenders use the Credit Risk Index to determine creditworthiness in different geographic areas. The index baseline is 100, but it rose to 124.79 at the end of 2008 — meaning that consumers are defaulting on accounts, loans and so on with greater frequency and in bigger numbers.The data is used at a broad level and has no bearing on individual loans and lines of credit. But for consumers, this number helps explain why it's much harder to secure a loan these days, and might hint at why more people are receiving notices from their credit-card company, informing them that their credit limit's been cut.Read the rest of Mary's story here.You can read TransUnion's press release here.
All In One Place: Citibank Coverage
Given how much Citibank coverage there is at CreditMattersBlog.com, it's become a necessity to put all of it in one place. During the past four weeks, I'd guess that half of my search traffic has been related to Citibank and the recent interest-rate increase that it smacked millions of customers with. I can only imagine how difficult it must be for a new reader — looking for specific information — to find what he or she is looking for. Let this blog entry, then, serve as an attempt to make life easier for those looking for information on Citibank.If you suffered a Citibank rate hike you might be able to get your APR reduced. A few of us have converted our cards, which resulted in lower APRs. Did You Suffer A Citibank Rate Jack? You May Be Able To Do Something About It—Maybe Citibank went too far with the rate jacks. Maybe too many people opted out. Citibank is sending letters to customers who opted out of a proposed rate jack — in an attempt to win them back. Unfortunately, Citibank doesn't seem to be offering any incentives to come back.Citibank To Customer Who Opted Out Of Proposed Rate Jack: Let Us Win You Back—Citibank's interest-rate hikes are not set in stone. Before opting out, you should give Citibank a call and make your pitch. This story tells you how to do it.Don't Accept Your Citi Hike Laying Down—Has Citibank recently increased your interest rate? Looking for an opt-out letter to send to Citibank? This story is for you.Opt-Out Letter For Citibank Credit Card Customers—What happens if you opt out of Citibank's interest-rate increase? How will your FICO score be impacted? What if this is your oldest account? This story looks at some of the issues that Citibank card customers will face.The Citibank Opt-Out Decision — Everything You Need To Know—CNN's Drew Griffin took Citibank to task for its rate-jack strategy. The timing of the hike, meanwhile, came right on the heels of a government bailout. Anderson Cooper 360 video on Citibank rate jack—Citibank's interest-rate increase impacts a wide range of customers. Some will opt out; some won't. What I want to know, and what I aim to figure out, is what Citibank will look like down the road — after the dust settles. Citibank's Rate-Hike Strategy — Where To From Here?—Michelle Malkin, blogger extraordinaire and Fox News contributor, highlighted one of her readers, who was miffed about an interest-rate increase she received from Citibank. In the process, Michelle used one of my stories to illustrate that her reader wasn't alone.Citibank Tells Cardholders To Take A Hike—If Citibank is raising interest rates on 20% — or fewer — of its cardholders, why is my interest rate being doubled?Citibank To Raise Interest Rates On CreditMattersBlog.com—Before Citigroup received a government bailout, the company — and its stock price — was on the ropes. In the meantime, Citibank card customers were feeling the pain. I highlighted a number of reader comments from my site, showing the breadth and impact of Citibank's interest-rate hike. Citigroup On The Ropes — Credit Card Customers Feeling The Pain—Citibank isn't the only card company sending change-of-terms letters to credit-card customers. If you receive a change in terms, and don't like the new ones, how do you reject them? That's what this story is about.Change of Terms in Your Credit Card Agreement — How Do You Reject The New Terms?—This is the story that kicked everything off. The Wall Street Journal was the first news publication to mention Citibank's interest-rate increase. Citibank customers, meanwhile, flocked to my site in droves. Indeed, this blog entry alone has received more than 230 comments.Citibank To Raise Interest Rates On Its Plastic—Other Citigroup/Citibank Odds and EndsA Conversation With Vikram Pandit, CEO of CitigroupShould Citi Field Be Renamed Taxpayer Bailout Field?Citibank Pulling A Large Number Of Its Credit Cards Out Of The Affiliate Marketing ChannelCartoon Of The Day: No. The Fed Will Not Give You $20 BillionU.S. Agrees to Rescue Struggling CitigroupCitigroup Plans To Cut An Additional 53,000 Jobs
Advanta Shuts Down Credit-Card Lending Amid Surging Charge-Offs
Beginning next month, Advanta credit-card customers will no longer be able to use their credit cards to make purchases. The card issuer says that customers will be able to pay their existing balances over time. The halt in credit-card lending, which takes place on June 10, will affect some 1 million customers. From Bloomberg:Advanta has reported three consecutive quarterly losses and has seen its shares plunge from about $30 in June 2007 to $1.13 at the close of New York trading yesterday. The U.S. jobless rate reached 8.5 percent in March, a 25-year high, squeezing sales for small business owners. The economic slowdown affected Advanta's customers across the country, Chief Financial Officer Philip Browne has said."We'll be shutting down accounts for future transaction activities, but many of the customers will maintain balances and pay us off over time," Browne said yesterday in a telephone interview. "We'll have to service and collect on that, and that will be the first order of business for the company." Desperate times call for desperate measures. Advanta hopes the halt in lending is temporary. However, my prediction is that Advanta will not survive. The card issuer caters to small-biz owners. Small business has been ripped during this economic downturn. Still, Advanta's business tactics likely didn't help matters either. The company reported a charge-off rate of 20% back in March. Given the card issuer's penchant for hiking rates to 30%+ on customers who are in good standing — and who have not missed any payments — it's not surprising that Advanta is now getting killed. You reap what you sow. Read the full story here.
5 Tips For Talking To Elderly Parents About Credit Card Debt
For many of us, this day is coming. At some point, we'll have to address the credit-card debt that our parents hold. Creditcards.com has a how-to piece, which offers some advice on how to approach the situation. Seniors, 65 and over, represent the fastest-growing group when it comes to rising debt. Better to tackle the conversation earlier rather than later, I say. From the story:For some senior citizens, credit card debt is a way of life that gets more difficult to handle as they get older. Julie Murphy Casserly of Chicago spent her whole life watching her parents struggle to pay the bills. By the time she was old enough to take a peek at their financial issues, they had $72,000 in consumer debt, including unpaid credit cards and old orthodontia bills. Even after Murphy Casserly, the author of 'The Emotion Behind Money: Building Wealth From the Inside Out,' helped her parents tap a home equity line of credit to pay off debt, bad health and poor money management skills soon created another mountain of debt in its place. 'It was a chronic problem,' she says.Many older people, even frugal ones, are simply unable to make ends meet on a pension or Social Security check, so they turn to plastic to pay for daily living expenses, like groceries and gas. Other seniors plunge into debt when their health takes a turn for the worse. A stroke, a heart attack or a bout with cancer can create thousands of dollars in medical bills, which elderly patients may be pressured to pay with a credit card.By the way, the kids might have something to do with elderly parents — and rising debt levels. I wrote a story last year about children moving back in with their parents. You can read that story here link.Read the rest of today's story here link.
Weeklong Series: Different Paths, Same Result: Good Credit Scores
During the week of August 18-22, 2008, I ran a series of question-and-answer interviews with people who had achieved credit success — even if getting there wasn't always easy. Instead of finding people with perfect credit I could have done that without a problem, who have never had a blemish or setback during their entire credit lives, I figured that I would find a mix of people to interview. And this note: with the exception of one, all of my interviewees requested that I not use their entire name for these interviews. In one case, one of my interviewees insisted that I use an alias, as he didn't feel comfortable putting his real name on the Internet. That said, given the current credit climate, I don't blame any of them for wanting to retain some anonymity. Credit card company employees read my blog on a regular basis, so I can understand their concern. In this weeklong series, you'll certainly see people who have led perfect credit lives. But you'll also find people who stumbled along the way. Regardless, what I hope to do with this series is show you that there is more than one way to slice and dice a credit portfolio — and score.What's more, I'm hoping that these stories will inspire you. We're all at different stages in our credit journey. Some lead charmed lives and have never experienced financial setbacks. Others may be in the middle of a financial firestorm even now. Others may be on the road back from financial trouble. Still others may be heading down the wrong path even as they're reading this series.Whether you are moving up, down, or sideways, I'm hoping that you enjoy this series. I'm hoping that you'll take something away from it — something that helps you achieve all of your credit goals.I'd love to hear your feedback from these stories. Feel free to comment on any and all of them.Monday: One Man's Struggle to Overcome Bankruptcy — and Reach FICO 800 link here2 For Tuesday: 1 Have a Plan if You Want to Keep Your Scores High link here; 2 Patience is a Virtue but Paying in Full is Divine link hereWednesday: Bigger, Better, and Smarter — How Rebecca Bounced Back From Consumer Credit Counseling link hereThursday: Who Needs FICO 800? Scores of 760 to 799 Work Just as Well link hereFriday: Having a High FICO Score is Nice — But it's Just One Piece of the Financial Puzzle link here
3rd Circuit Deals Blow To Class-Arbitration Waivers
Good news for credit-card users. Bad news for the credit-card industry. The 3rd Circuit Court of Appeals held that arbitration clauses may be struck down — as unconscionable — when they prevent the use of class actions in cases where a large group of consumers have claims that would normally yield small sums of money for individuals litigating on their own. From The National Law Journal:The unanimous three-judge panel concluded that state courts as well as federal courts applying state law are free to declare that such class-arbitration waivers are unconscionable — even if the contract included a choice-of-law provision that called for applying the law of a state that is decidedly amenable to such pro-business provisions.The ruling is a victory for attorney F. Paul Bland Jr. of Public Justice in Washington, D.C., and Gary S. Graifman of Kantrowitz Goldhamer & Graifman in Montvale, N.J.Bland hailed the ruling as a major victory for consumers and said it clarified an important area of 3rd Circuit law by underscoring the power of state courts to reject arbitration and anti-class action provisions they deem unconscionable.In the suit, a proposed class of New Jersey consumers claim that American Express cheated them by falsely promising rebates of up to 5 percent of purchases made with the Blue Cash Card, and that, in reality, the rebates proved to be much smaller than originally promised.The 3rd Circuit remanded the case. On remand, the district court judge will have to decide whether New Jersey state courts would deem such a class-arbitration waiver provision unconscionable. 'We hold that, if the claims at issue are of such a low value as effectively to preclude relief if decided individually, then … the application of Utah law to the class-arbitration waiver is invalid and the class-arbitration waiver is unconscionable,' U.S. Circuit Judge Franklin S. Van Antwerpen wrote. Given that most of these credit-card disputes involve relatively low-dollar amounts, not worth a single individual's time, money, or effort, I'm hopeful that the district court judge will find these class-arbitration waivers unconscionable. You can read the rest of the story here link.
The 100 Most Useful Web Sites — All Money Related
Liz Pulliam Weston, one of the best personal-finance writers extant, has compiled a list of what she calls 'the 100 most useful Web sites.' I'm constantly on the prowl for information — as are most of my readers — so I figure this will make a great Saturday blog entry. By the way, Liz included CreditMattersBlog.com on the list. Thanks, Liz! I was included in the 'Best sites for managing your credit' category. From the column:AnnualCreditReport.com. This is the government-run clearinghouse to get your legally mandated free credit reports — you get one per year each from Experian, TransUnion and Equifax. Accept no imitations.CardRatings.com. This site does more than highlight some of the best available credit card offers. It also advises users on how to best manage their credit, pay off debt and deal with credit crises. LowCard$.com and Index credit cards are good to check, too.Credit.com. Two of my favorite credit experts, John Ulzheimer and Gerri Detweiler, contribute to this site, which educates users about all things credit-related.CreditCards.com. Former Bankrate.com editor Dan Ray has added smart, timely content to what was once just a collection of credit card offers. You can search for those here too, of course, but also check out the breaking news stories, the advice and the expert Q&As.CreditMattersBlog.com. Run by a former Wall Street reporter and soon-to-be lawyer, this blog tracks changes in the credit markets and has broken more than a few stories, including the one about American Express paying some customers $300 to close their accounts.myFICO. If you're going to pay for a credit score as opposed to a credit report, which you should never pay for, you might as well get a FICO, which is the scoring formula most lenders use. This is where you can buy FICOs for Equifax and TransUnion. The third credit bureau, Experian, no longer sells FICO scores to consumers. The site also has a lot of great information about how your scores are figured, what interest rates your scores qualify you for and how to improve your scores.I visit quite a few of the sites on Liz's list. Still, that's just the credit section of her list. Looking forward to exploring some new ones outside of the credit area. Do yourself a favor and check out the other 94 sites that made Weston's list.Read Liz's story here.
The 10 Most Important Stories Written By CreditMattersBlog.com
This blog entry is inspired by a comment that one of my readers made to me a few days ago. This reader, Zach, said that a particular story I did more than three months ago was one of my more 'educational and unique' blog entries see Zach's comment here. That got me to thinking. I've written a lot of stories during the past five months. Indeed, there are now some 235 stories on this site. Of those 235 stories, there are some really fundamental stories. Some more important than others. In light of Zach's comment, though, I thought it would be a worthwhile project to highlight ten of the most important stories that I've done at CreditMattersBlog.com since July. My list moves from ten down to one with one being the most important. 10. When it Comes to Credit, it's Always Business link9. Lowering Your Credit Limit is Stupid plain and simple link8. Why You Need a Credit Union Relationship link7. When Should We Start Teaching Our Kids About Credit?link6. Want to be a FICO High Achiever? Do What They do link5. If Your Relationship Ended Today, Would you be Prepared?link4. Paying in Full is Not Only Good For Your FICO Score — It's Good For Your Piggybank Too link3. During the Credit Crunch, Work That FICO Score link2. If You Don't Have A Credit Plan, You're Doing Something Wrong link1. Utilization: What It Is And Why It Matters link
10 Credit Questions and Answers at CreditMattersBlog.com (October 30, 2008)
As I have said before, I can see how my readers find CreditMattersBlog.com. I don't collect any personal information, but I can see search terms that people use to find the site. This information is like the center of Lifesavers candies. Or doughnut holes. Rather than letting them fall by the wayside, I figure that I should put these search queries to good use. Here are the game rules: I will edit search queries for syntax purposes. Otherwise, I will leave them alone. I'll also phrase queries in the form of a question whenever possible. By request, these Q&As will now be published whenever I have received 10 questions through Google, Yahoo, and AOL searches.Q: How to keep credit card companies from reducing limits on inactive cards?A: That's not your biggest worry with inactive cards. What most people should worry about is having the account closed. While I am sure that inactive cards can see a reduction in limit, I would think that the more common result would be an account closure. If you don't want the account closed, be sure to use the card periodically.–Q: Keep getting denied for credit card — serious delinquency.A: In this credit environment, get used to it. Card companies are finally doing some real underwriting and risk management. During 2006, you could get a card with a serious delinquency. Now, though, it's a much different situation. Card companies are reining in credit limits and they're taking adverse action on those who have blemishes. There is also a compound problem here. The serious delinquency is preventing you from getting a new card, but the new inquiries are now damaging your chances as well. Those new inquiries make it look as though you are seeking new credit. If you have enough new inquiries, it will make it look as though you're desperate, too.–Q: Should I call Nordstrom after applying for a credit card?A: Nordstrom takes its sweet time with card approvals and denials. Expect to hear something from Nordstrom within 7-10 days. However, if you are eager to find something out, feel free to call three to four days after you submit your application. Nordstrom may be able to give you the status of your application at that time. You can call using this phone number: 800-964-1800.–Q: My credit is shot.A: Sorry to hear that. I wrote a story a few months ago regarding shot credit link here. Some of my readers may find it useful.–Q: How to reduce credit limits without hurting credit score?A: While I don't generally advise people to lower their credit limits, if you are intent on doing it here's what you do: You'll need to reduce your spending. The key is to keep your utilization down. You can only keep your utilization down when you spend less. When people reduce their limits, they're essentially making it more difficult on themselves. I wrote a story on reducing limits link here back in July. Give it a read. –Q: What interest rate is better — .99% for a limited time or 5.99% until balance is paid off?A: This is where the calculator comes in. If you can pay off your balance quickly, then the 0.99% interest rate will likely work best. However, if you KNOW that you won't be able to take advantage of the 0.99% rate — because your repayment schedule is going to be drawn out — it may be that your 5.99% rate will do the trick. Figure out what the 0.99% rate will go to when the promotion ends. Then figure out how long you think it will take to pay off the balance. If you estimate that you'll save more money with the 0.99% rate plus the go to rate, then opt for that. If the 5.99% rate pencils out, then go for that.–Q: TrueEarnings American Express vs. USAA American Express? A: I am finally starting to see more questions like this. People are getting more shy about American Express, so they are looking for cards that use the American Express payment network. USAA underwrites the American Express card that it issues. The True Earnings American Express is underwritten by American Express in New York. The American Express in New York is the one that loves to do credit limit decreases and financial reviews. USAA, on the other hand, doesn't roll like that. Now, there are differences between the cards. And they're big differences. The TrueEarnings card is geared toward Costco shoppers. 'The TrueEarnings Card serves as both your American Express Credit Card and your Costco membership Card,' according to American Express. What's more, there is no annual fee on your TrueEarnings card if you have a paid Costco membership. Additionally, you get a rebate of 3% for gasoline, 3% for restaurants, 2% for travel, and 1% everywhere else, including Costco, with your TrueEarnings card. The USAA American Express card, though, doesn't offer a lot of rewards. But it will allow you to shop where American Express is accepted, including Costco. For people who don't want to do business with American Express in New York, but who still need an American Express card to shop at Costco, the USAA American Express will do the trick. Just don't expect a whole lot from the USAA card in terms of rewards and rebates. –Q: Should I request a credit line increase or get a second credit card?A: I always prefer to get a credit-limit increase. If I get a second card instead, the new account will bring the overall age of my credit history down. I'll also get a hard inquiry for the trouble. With a credit-limit increase, there is a chance that the card company won't pull a hard inquiry check with your card company to see what its policy is. And I won't have to worry about a new account showing up on my credit report. Therefore, my general rule is this: go for a credit limit increase first. If that doesn't satisfy your need for more credit, then perhaps you might go for a second card.–Q: Preselector HSBC?A: Yes. HSBC has a card preselector that will point you to cards that HSBC thinks you would likely qualify for be warned, though, that there are no guarantees of an approval. The HSBC preselector will ask you for some basic information and it will require a credit pull though it will be a soft pull that won't hurt your credit score. You can find the preselector here link here.–Q: Authorized user on maxed out account.A: If you are an authorized user on a maxed-out credit card, your FICO score is likely being harmed. Rather than go into a long spiel about the perils of this situation, you should read my primer link here on authorized users. READER ALERT: For more credit questions and answers, the entire 10 Credit Questions & Answers index can be found here link.


text: The Story of VELCADE™ A Biotech Love Story The Life-Cycle of Intracellular Proteins Synthesis Proteins Degradation Amino Acids Ubiquitin-Proteasome Pathway Ub Ub Ub Ub Ub Ub ATP Ubiquitination Enzymes ATP Peptides 26S Proteasome Complex Ubiquitin-Proteasome Pathway The Nobel Prize in Chemistry 2004 "for the discovery of ubiquitin-mediated protein degradation" Aaron Ciechanover 1/3 of the prize Israel Avram Hershko 1/3 of the prize Israel Irwin Rose 1/3 of the prize USA Crystal structure of the 20S proteasome Central cavity built by two rings of beta subunits cut open along the sevenfolfd axis: O H 3C N H O H N N H O H O NH2 H 3C O R OH Ac-Leu-leu-norleucinal inhibitor bound to the N-terminal threonine of the beta subunity Aldehyde Surrogates O O O H N N H N H O MG-132 N H B OH OH H O Proteasome Inhibitors: Mechanism of Inhibition Boronic acids R2 General structure:P N H O H2 N H OH H N B R1 NH 3 H O H H 3C H O R B OH OH R B OH OH H O O H 3C OH PS-341: In Vitro Activity • Cytotoxicity involves multiple mechanisms of action – Stabilization of cell-cycle regulatory proteins – Inhibition of NF-B activation – Anti-angiogenic – Induction of apoptosis – Override of bcl-2 resistance O N N N H H N O – Weak mdr substrate – Hypoxic cells are hypersensitive Ki=0.6 nM OH B OH How Proteasome Inhibition Works Normal Cells: less Normal Cells: sensitive than cancer cells to proapoptotic effects can recover Proteasome inhibitors block the proteasome, producing conflicting regulatory signals and interfering with critical cellular functions Cancer Cells: have Cancer Cells: can difficulty processing overload lead to apoptosis 1995 to 1997 Preclinical Work in Cancer • ProScript teams up with the NCI to test tumor cell lines (CRADA) – Ed Sausville • Lewis lung carcinoma model in mice tested at Dana Farber – Beverly Teicher • Multiple mouse models of cancer, including prostate, colon – Al Baldwin/Jim Cusack/Ken Anderson/ David McKonke 1998 VELCADE Clinical Development Begins • June 8th NCI officially endorses package – Unanimous vote • July 24th IND submitted (#56,515) – >3,000 pages (Matthew Smith, MD) • October 7th first clinical trial (prostate) at MDACC – Supported by a grant from CapCURE (Howard Soule) – Chris Logothetis Development of PS-341 > Bortezomib > VELCADE™ PS-341 finished drug product (lyophilized) ca. 4000 vials (February 1999) Antitumor Activity (Objective Measures) Disease n Evaluation Prostate (1x/wk x 4; 0.4 mg/m2) 1 Radiographic Prostate (1x/wk x 4; 1.6 mg/m2) 3/16 Renal (2x/wk x 2; 0.75 mg/m2) 1 Radiographic Head & Neck (2x/wk x 2; 1.3 mg/m2) 1 Radiographic Lung (2x/wk x 2; 1.56 mg/m2) 1 Radiographic Melanoma (Lung Mets) (2x/wk x alt. wk; 1.0 mg/m2) 1 Radiographic PSA reduction; Radiographic Antitumor Activity (Objective Measures) Disease n Evaluation Follicular NHL (2x/wk x 4; 1.38 mg/m2) 1/2 Radiographic Mantle Cell NHL (2x/wk x 4; 1.38 mg/m2) 1/3 Radiographic AML (2x/wk x 4; 1.25 mg/m2) 1 Multiple Myeloma (2x/wk x 4; 1.04 mg/m2) 7/10 Bone Marrow & IgG Waldenstrom's (2x/wk x 4; 1.2 mg/m2) 1/1 Bone marrow; IgM Reduction in circulating blasts PS-341 in Multiple Myeloma • Multiple myeloma demonstrates a strong dependency for NF-B and NF-B-dependent genes as growth factors and adhesion of plasma cells in the bone marrow (IL-6, VEGF, VCAM-1) • PS-341 potently down-regulates these genes • PS-341 is pro-apoptotic at 1-10 nM range in human MM isolates with and without stromal cell environment T. Hideshima et al., Cancer Res. 61, 3071-3076 (2001). 2000, continued • Oct 12th MMRF invites Dr. J to participate at their round table with MM investigator "dream team" • Oct 12th (Dr. J pulls a fast one!) MMRF president, Kathy Giusti agrees to a closed door meeting with investigators: Summit protocol is designed … – Michael Kauffman, Dixie Essletine Multiple Myeloma: 2000 32,000 Newly Diagnosed per year (14K/yr US, 15K/yr EU, 3K Japan) 5-year Mortality, 75%, 10-year Mortality, 95-98% Diagnosis •Survival 3-5* yrs •Survival <6mo without therapy First-Line: • VAD or CVAD • MP •*Transplant 50 - 75% Response Rate All patients relapse Relapsed Disease •Transient Response to Therapy •Survival 1-3 years Second Line: • VAD or CVAD • Dexamethasone • Transplant • Investigational Therapy Refractory •Resistant to all therapy •Universally fatal •Survival 6-9 months Refractory: • Supportive or palliative care • Investigational Therapy • Deaths 12,000/yr. Unmet Medical Need PS-341 Focus Previous Therapies 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% • Median lines of prior therapy = 6 (range 2-15) • 91% had progressed on last therapy before entry Overall Survival and Time to Progression (N=202) 1.0 0.9 Median Survival: 16 months 0.8 Proportion 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 0 6 Months 12 18 Conclusions • In 202 patients with relapsed and refractory multiple myeloma bortezomib achieved – – – – – Documented CRs (4% Blade, 6% IF+) Overall response rate (CR+PR+MR) of 35% Median duration of response (12 mo) Overall survival (16 mo) Improvement in other disease parameters observed in responding patients, including hemoglobin and quality of life. – Well-tolerated and manageable side effects – VELCADE approved May 13, 2003 (Dr J is happy!) Bortezomib: First Proteasome Inhibitor Approved • Full approval, in second line relapsed MM(Bort vs Dex) 2004 • Mantle cell lymphoma approval, 2006 • Front line approvals in combination with Melphalan/prednisone, other regimens as well, 2008 • Re-treatment with Bortezomib leads to re-response to treatment (~50% of patients) Thank You: Patients and Caregivers Michael Kauffman David Schenkein Ken Anderson Paul Richardson and the Myeloma Investigators NCI, CapCure (PCF), MMRF, IMF ProScript Inc. (Peter Elliott and Vito Palombella) Millennium Pharmaceuticals Inc. Collaborations! Patient Advocacy Industry Academic Institutions Government Patients and Families So where do we go from here? The Hedgehog Pathway in Cancer: Targeting the Cancer Environment and Prolonging Remissions to Make Cancer a Chronic Disease… The Hedgehog signaling pathway *Chen et al., 2002 G&D 16:2743 The Hedgehog signaling pathway *Chen et al., 2002 G&D 16:2743 The Hedgehog signaling pathway Cyclopamine *Chen et al., 2002 G&D 16:2743 Cyclopamine Sourcing Veratrum californicum primarily found in western United States Source: PLANTS database, USDA Veratrum californicum is readily found in the wild 33 Cyclopamine: Starting Point for an Oral Hh Antagonist? Sourcing of material H HN 27 22 18 23 13 11 19 H 1 H HO 3 17 5 6 O H Poor pharmaceutical properties: Solubility 12 (5 mg/mL in pH 7) H Chemical stability (low at pH 1.9) Low potency 34 Overview of Cyclopamine Sourcing Biomass sourcing • Veratrum californicum • Primary collection sites: Idaho and Utah USFS agreement Drying & Milling • Alkaloids Extraction Extraction Isolation • Chromatography • Crystallization • Typical purity > 95% Cyclopamine isolation is efficient and scalable Keeler RF. Phytochemistry. 1968;7:303. Oatis Jr JE, et al. Chemistry Central Journal. 2008;2:12. 35 IPI-926: Potent and orally active Smo inhibitor from the natural product H O cyclopamine NH H H H HO H ↑ Solubility ↑ Chemical stability ↑ Potency ↑ Selectivity ↑ Metabolic Stability H O Cl N H HH H O H3C S N H O H H H IPI-926 36 Malignant Activation of the Hedgehog Pathway in Cancer Ligand dependent Ligand Independent Target tumor cell Target tumor cell Ptc mutant tumors ? Inhibit oncogenic signaling Tumor cell apoptosis Advanced BCC, Medulloblastoma Inhibit autologous signaling ? Target microenvironment Target residual disease Desmoplastic tumors Solid Tumors Heme Malignancies Decrease fibrosis Improve drug delivery Improve survival Maintenance after debulking Improve PFS Elimination of progenitor Potential cure Pancreatic cancer SCLC, OvCa, NSCLC CML, CLL, ALL, AML, MM IPI-926 in Minimal Residual Disease (MRD) Small cell lung cancer LX22 primary xenograft model • LX22: Chemo naïve, patient-derived primary tumor established subcutaneously and maintained in mice • Sensitive to etoposide/carboplatin Primary xenograft model IPI-926 delays LX22 tumor recurrence following chemotherapy Tumor size (mm3) Vehicle IPI-926 E/P → Vehicle E/P → IPI-926 End E/P Days LX-22 – Primary small cell lung cancer xenograft model treated with Etoposide/carboplatin. IPI-926 is initiated 24 hours after the last dose of chemotherapy. Chemotherapy Upregulates IHh Ligand and Signaling to Stromal Cells Human IHh expression 12 7.5 5 2.5 0 Naïve Vehicle IPI-926 Pre-treated with E/P Fold change mGli-1 Fold change hIHH 10 Murine Gli-1 expression 9 6 3 0 Naïve Vehicle IPI-926 Pre-treated with E/P Travaglione AACR 2009 Primary ovarian tumor xenografts • Primary tumors passaged mouse-to-mouse • Preserved serous histology throughout transplant generations Growden and Rueda, SGO 2009 IPI-926 Delays Regrowth of Ovarian Cancer Following Carbo/Taxol Treatment 120 Carbo/Taxol Carbo/Taxol/926 Relative tumor volume (%) 100 80 Last C/T dose 60 40 Last 926 dose 20 0 D1 D4 D9 D12 D16 D19 D23 D26 D30 D33 D37 D40 D44 D47 D51 Day (post treatment) Carboplatin 50 mg/kg IP, Paclitaxel 15 mg/kg IP q 7d; IPI-926 40 mg/kg PO, QOD ; Growden, Rueda MGH SGO 2009 A Phase 1 study of IPI-926 in patients with advanced and/or metastatic solid tumor malignancies • Clinical sites – Glenn Weiss, MD – TGEN – Charlie Rudin, MD – Johns Hopkins – Antonio Jimeno, MD – Univ. Colorado • Trial design – Accelerated phase followed by standard dose escalation • Objectives – Safety, pharmacokinetics, PD, and dose-ranging study Recommend Phase 2 starting dose • Markers of response – Response by RECIST criteria, PET, and disease specific tumor markers, tumor biopsies – PD assay - skin biopsy Acknowledgements W. Matsui N. Watkins R. Vessella B. Rueda C. Dierks T. Lin Ken Olive, Dave Tuveson Johns Hopkins University Johns Hopkins University University of Washington MGH University of Freiburg LSU Cambridge University The Infinity Team


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Telephone & Addresses
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Louise Griffiths
44145 Westlake OH
Louise Griffiths
90036 Los Angeles CA
Louise Griffiths (Age: 58)
84093 Sandy UT
Louise Griffiths, Los Angeles, S Genesee Ave
View Louise's social profiles and photos on Facebook, MySpace, and +40 Networks.
Yellow Page contacts
Network Profiles
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Jesse Spencer and Louise Griffiths Reportedly Split
After dating for a year and a half, Jesse Spencer and singer girlfriend Louise Griffiths allegedly have gone their separate ways.
Louise Griffiths hot photos, hot pictures, videos, news, gossips,...
Louise Griffiths hot photos, hot pictures, news, videos, movies, songs, lyrics, music albums, filmography, discography, biography and many more!
lastFM: Louise Griffiths — Free listening, videos, concerts, stats and...
Louise Griffiths on Last.fm. People who like Louise Griffiths also like Carolynne Good, Audley Anderson, James Fox. Discover more music, concerts, videos, and...
Jesse Spencer and Louise Griffiths Reportedly Split - House M.D. ...
09.04.2010 A link to an external website Jesse Spencer and Louise Griffiths Reportedly Split submitted by a fan of House M.D.. (11383107)
Business Profiles
Laura-Louise Griffiths, Model, Oxford, England, United Kingdom
Official model mayhem page of Laura-Louise Griffiths; member since May 17,2010 has 8 images, 180 friends on Model Mayhem.
Louise Griffiths | Purple Co Freelance Consultant at | ZoomInfo.com
Find business contact information for Louise Griffiths, Associate Director, Insight Research Group and see work history, affiliations and more.
Private Homepages
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Home - Louise Griffiths
I work with coaches & consultants to produce an effective marketing strategy to boost leads & conversions allowing you to get on with what you love doing.
Emma Louise Griffiths – Fashion Stylist
I am a London based Fashion Stylist and Writer, and have always held a strong interest in the fashion industry. In my spare time I write my own fashion and...
LAY'S® Chip Love Commercial - Louise Griffiths Online Gallery
Louise Griffiths Online is an unofficial fansite dedicated to Louise Griffiths. We are no way affiliated or connected with Louise Griffiths nor with her relatives or
Gabrielle - Gabrielle's Gala fundraiser | 39 Pictures |...
Gabrielle and Louise Griffiths Wednesday 7th May 2014, Gabrielle's Gala fundraiser - Contactmusic photo 4184249
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classmates: Louise Griffiths
Avon High School, Avon, IN, 1940-1944
classmates: Louise Griffiths
Rockbridge County High School, Lexington, VA, 1936-1940
classmates: Louise Griffiths
Beacon High School, Beacon, NY, 1992-1996
classmates: Louise Griffiths
Elizabeth High School, Elizabeth, NJ, 1974-1978
Celebrities & Politicians
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IMDB Filmography: Louise Griffiths
Producer, I Can Do It
IMDB Filmography: Louise Griffiths
Self, The One Show
Bad news
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legacy.com: Louise Griffiths
ASHLAND — Louise Griffiths, 90, formerly of Ashland, died Sunday, May 17, 2009, at Mount Carmel Nursing and Rehabilitation Center. Born in Ashland on Dec. 4, 1918, she was
legacy.com: Louise Griffiths
May 17, 2009 Louise Griffiths, 90, formerly of Ashland, died Sunday at the Mount Carmel Nursing Center. Born in Ashland, Dec. 4, 1918, she was a daughter of the late John
legacy.com: Louise "Weezy" Griffiths
Louise Griffiths, 92, passed away peacefully on November 1, 2011 surrounded by her family and loved ones at the hospice center following a battle with lung cancer. Weezy was a
findagrave: Griffiths, Louise Burgess
12/1/1923 - 04/1/2011, Salt Lake City (Salt Lake County, Utah)
Louise Griffiths (1897 - 1975) - Genealogy
Genealogy for Louise Griffiths (1897 - 1975) family tree on Geni, with over 140 million profiles of ancestors and living relatives.
Mary Louise Griffiths (1870 - 1944) - Genealogy
Genealogy for Mary Louise Griffiths (1870 - 1944) on Geni with over 100 million profiles of ancestors and living relatives. Page updated May 24, ...
kelly-louise griffiths is fundraising for Stand Up To Cancer in ...
Share on Facebook; Tweet; Email. Page owner kelly-louise griffiths. kelly-louise griffiths's Just Giving Page. Event: Stand Up To Cancer on ...
Books & Literature
The New Cosmology - Google Books
I thank Louise Griffiths for producing Fig. 10 and Patrick Leung for producing Figs. 12 & 13. The HEALPix package (Górski, Hivon and Wandelt 1999) was used ...
Louise Griffiths Films on iTunes
Preview and download top songs and albums by Louise Griffiths on the iTunes Store. Songs by Louise Griffiths start at just .
Louise Griffiths Movies on iTunes
Preview and download movies by Louise Griffiths, including The Devil's Chair, Chastity Bites and Unknown Caller.
Related Documents
File:Louise Griffiths 2008.jpg - Wikimedia Commons
English: Louise Griffiths attending the second issue release of "Girls Gone Wild Magazine" Party at Les Deux, Hollywood, June 4, 2008. Photo by Glenn Francis ...
The Revenant (2012) - Movie | Moviefone
The Revenant - Search for movie plot, trailers, cast and crew, photos, reviews, and tickets online at Moviefone
Video & Audio
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BlinkX Video: Red Alert 3: Uprising - Soviet Cinematics (HD)
Soviet Campaign Cinematics. Cast: Gemma Atkinson - Lt. Eva McKenna Jamie Chung - Takara Ric Flair - Commander Hill Louise Griffiths - Lydia Julia Ling - Izumi Bruce Locke -... - 04.01.2009, YouTube
BlinkX Video: Tekken (Film Cast)
Lee Chaolan: Heihachi Mishima's adopted son, and rival of Kazuya. Other appearances includes Mircea Monroe as Kara, David Pitt as Jack, Louise Griffiths as Sapphire, Randal Reeder... - 03.18.2009, YouTube
BlinkX Video: Red Alert 3: Uprising - Empire of the Rising Sun Cinematics (HD)
Empire of the Rising Sun Cinematics. Cast: Gemma Atkinson - Lt. Eva McKenna Jamie Chung - Takara Ric Flair - Commander Hill Louise Griffiths - Lydia Julia Ling - Izumi Bruce Locke... - 04.01.2009, YouTube
Películas que contengan louise griffiths, Filmografías que contengan...
Busqueda de Louise Griffiths, pelicula Louise Griffiths filmografia de Louise Griffiths, estreno de Louise Griffiths, premios de Louise Griffiths, fotos de Louise Griffiths, comentarios de Louise Griffiths, curiosidades de Louise Griffiths
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Google News: Ex de Button vira-se para o "Ídolos"
21.10.2012 [Record] - Não, Louise Griffiths não vai experimentar o palco de um dos concursos de talentos mais conhecido do Mundo. Na verdade, a ex-noiva de Jenson Button está de namoro com Simon Cowell, o inglês que ficou conhecido como o mais irascível jurado das
Jenson Button's ex Louise Griffiths 'dating' Simon Cowell
20.10.2012 [Newstrack India] - London, Oct 20 (ANI): Simon Cowell, who is known for living life in the fast lane with his busy schedule, making his many relationships end as quickly as they started, is reportedly dating F1 ace Jenson Button's former fiance, UK singer Louise Griffiths.
Google News: Simon Cowell is 'dating' Jenson Button's ex fiancée Louise Griffiths
19.10.2012 [Daily Mail (blog)] - Simon Cowell is well known for living life in the fast lane with his busy schedule making his many relationships end as quickly as they started. However, the X Factor supremo has become smitten after he began dating the ex fiancée of Formula 1 driver
Simon Cowell heeft een nieuwe vriendin
19.10.2012 [Het Laatste Nieuws] - De 53-jarige Brit is naar verluidt samen met Louise Griffiths, de ex-verloofde van Formule 1-ster Jenson Button. "Het is allemaal nog heel pril maar er is zonder enige twijfel heel wat chemie tussen die twee", vertelt een vriend van Louise aan de
Reports & Statements
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Twitter Posts: Łῧçʞϔ (lucky0824)
2012.07.02 Hey Louise Griffiths!! I want you on My face RIGHT NOW!
Simon Cowell Is Romancing Button's Ex
19.10.2012 [San Francisco Luxury News] - The 53-year-old music mogul has enjoyed a string of dates with Louise Griffiths – who was previously engaged to Formula 1 star Jenson Button until 2005 – and even invited her to his Beverly Hills home to celebrate his recent birthday. A friend of
Twitter Posts: Łῧçʞϔ (lucky0824)
2012.07.01 Louise Griffiths http://t.co/TT9UVO0B via @youtube
Twitter Posts: Łῧçʞϔ (lucky0824)
2012.07.01 Louise Griffiths -- lady can you please sit on my face
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Simon Cowell has ANOTHER new lady! Jenson Button's ex, Fame ...
19.10.2012 [Yahoo! omg! UK] - Just the other day he was caught snogging the face off Carmen Electra, however Simon Cowell already reportedly has a new lady friend in the form of Louise Griffiths. Louise is reported to have been spotted out on dates with Simon. Copyright: [rex/wenn]
Cowell dating Button's ex fiancee?
20.10.2012 [Hindustan Times] - The X Factor boss Simon Cowell is reportedly dating Formula 1 driver Jenson Button's ex fiancee Louise Griffiths. The 53-year-old has been seen going to a number of dates in the recent past. "It is very early days but there is certainly a chemistry
Íme az X-Faktor atyjának nője
20.10.2012 [Paraméter] - A barátnő castingból pedig az utóbbi, név szerint Louise Griffiths került ki győztesen. A Cowell-től csaknem két évtizeddel fiatalabb modell már hetek óta randizgat a zenei guruval. Louise egyébként öt esztendőn át ugyanis Jenson Button párja volt. A
Louise Griffiths Profile - Metacritic
Reviews and scores for films involving Louise Griffiths.
Happy Birthday Darcie Odom!! - Celebrity Pictures, Celebrity ...
14.08.2011 ... Lonelygirl15 (1); Louie Anderson (1); Louis Carreon (1); Louise Griffiths (1); Lucy Devito (1); Lucy Liu (2); Madeleine Stowe (1); Madonna (3); Maksim Chmerkovskiy (1); Mandy Moore (3); Marc Chamberlain (1); Marcia Cross (5) ...
The social media measurement smackdown
19.02.2012 http://www.facebook.com/louise.griffiths Louise Griffiths. "However there are many meaningful leading indicators and non-financial measures that can be tied to stakeholder value." – I couldn't agree more! At the end of the day when you begin ...
Louise Griffiths In Hollywood! - Celebrity Pictures, Celebrity Videos ...
26.09.2007 Louise Griffiths In Hollywood! Posted Wednesday, September 26, 2007 by PukeMeister. cp-england1.jpg. Uk actress Louise Griffths arrives at the Intermix party in Beverly Hills! Photo:CelebrityPuke.com ...
Beauties of the Month: Louise Griffiths, Helen Mirror, Veronica Lake,...
Beauties of the Month: Louise Griffiths, Helen Mirror, Veronica Lake, Sanaa Lathan, Aditi Shankardass, & Sara Rue! November 16, 2014 by CT Esthetic Leave a ...
ClippingBook - Louise Griffiths (Jesse Spencer's chick)
ClippingBook - View Louise Griffiths (Jesse Spencer's chick) book, created by Lachony Puntocom in Celebrities category.
Emma Louise Griffiths : Birthday : St Helens Star
(15th May 2008) EMMA-LOUISE GRIFFITHS 14th May 2008 Lots of love and kisses Mummy and Daddy x x x.
Louise Griffiths - Bloody Disgusting!
Olson's Unknown Caller, a new indie thriller starring Louise Griffiths, David Chisum.
Louise Griffiths Biography, Wiki, DOB, Family, Profile, Movies,...
Read about Louise Griffiths Biography, birthday,age,family,affairs,spouse and kids,Louise Griffiths's first movie and upcoming movies details,profile,movies...
Louise Griffiths - The Yoga Practice, Herefordshire & Powys
Louise Griffiths. The full benefit of a yoga practice was revealed to me when I discovered yoga in the tradition of TKV Desikachar, widely known as viniyoga.
Louise Griffiths Explained
What is Louise Griffiths? Louise Griffiths is an English pop singer-songwriter, fashion model, and actress.
Louise Griffiths Knows "You Can't Eat Just One"!
That beautiful woman seductively eating those tater chips is actress and pop star Louise Griffiths. She's a beautiful Brit transplanted to L.A. and ...
Louise Griffiths Looks - StyleBistro
1+ Louise Griffiths looks, including Medium Curls and more.
Louise Griffiths - results | Raru
Louise Griffiths (7 results). Sort by. Relevance, Alphabetical, Priced Low to High, Priced High to Low, Release Date. Cover ...
Jenson Button enjoys a friendly catch-up with ex-fiancee Louise...
F1 driver chatted to former Fame Academy singer over lunch in LA, six years after they called off their wedding.
Louise Griffiths Wiki, Bio, Married, Husband or Boyfriend
Know more about Louise Griffiths Wiki, Bio, Married, Husband or Boyfriend. Louise Griffiths is an English fashion model; pop singer-songwriter as well as an...
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The Hotel Mercure San Sebastián Monte Igueldo is ideally located on Mount Igueldo, offering panoramic views over the Bay of La Concha. It is connected to the city by a fully functional century-old funicular railway. The hotel has an outdoor swimming pool,which is open during the summer months, meet...
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It's not a regular occurrence that you discover you need a replacement Headlight for your car or truck. Obviously, you didn't buy your 535i unless you understood you would be getting best-in-class service and a trusted brand both impeccably combined into one car, truck, or SUV. You picked your 535i because its sporty handling and European styling struck a chord inside you; so why would you settle for second rate when it comes to superior quality auto parts? BMW automobile owners have grown accustomed to a certain level of a reputation for performance when driving their 535i around town.
When it comes to safety devices on our vehicles, all parts should be functioning at maximum potential. Perhaps the most important safety parts on your BMW 535i are your headlights. It is impossible to drive at night without your BMW 535i headlights. All the headlight bulbs must be working properly and replaced when you notice a lack of illumination at night. And if your car or truck gets hit in the front by another vehicle, new headlights should be installed because of potential damage.
Given all the trouble that can be involved with repairing damage to your car or truck, let www.carpartsdiscount.com be the number one store you go to make buying it easy. At Car Parts Discount, we have real customer support agents here with enough expertise to help you purchase the appropriate BMW 535i part for your project or repair. Get your 535i back on the road with the best new or rebuilt parts from the experts at Car Parts Discount. If your car or truck was built in 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 1993, 1992, 1991, 1990, 1989, 1988, 1987, 1986, 1985, then you will find the correct BMW 535i Headlight parts right here.


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Find where you're going and take the most convenient route with our GPS Navigation System.
Built on the banks of the River Thames, London is one of the world's largest cities. Its many neighbourhood and boroughs are home to an abundance of culture, history, shops and museums. With its expansion and modern development, London's skyline has greatly changed over the past couple of decades, especially in the financial hotspot area of the city. If you don't mind heights, take a trip to the top of the Shard or have a tour on the London Eye. The famous Tate Modern remains contemporary with its excellent lights and if rent a car from London City Airport you can visit the Olympic Park.
East London has undergone extensive development during the 20th and 21st centuries, and is now one of the cultural hotspots of the city. Grab some food on the iconic Brick Lane, or visit the world's first pop-up mall, Boxpark. Hire a car from London City airport and you can explore Westfield Stratford City Shopping Centre, one of Europe's largest shopping centres in Europe or take a trip to Sutton House, a Tudor house built in 1535. If you venture into the centre of London, you can find the more famous sights of the city including Buckingham Palace and the Houses of Parliament.


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Ripoff Report
Gary, Best Rate Rent-A-Car4964 Starr Street SE Grand Rapids, Michigan U.S.A.
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This report was posted on Ripoff Report on 02/07/2005 09:08 AM and is a permanent record located here: http://www.ripoffreport.com/reports/gary-best-rate-rent-a-car/grand-rapids-michigan-49546/gary-best-rate-rent-a-car-ripoff-dishonest-fraud-illegal-removing-switching-of-vin-s-dr-130387. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Ladies and gentlemen, put your donuts and cookies aside, and let's talk about how sugar feeds your cancer. Yes, sugar is bad for your cancer, as cancer loves sugar, and we certainly don't like cancer.
Several studies and researches have come to a mutual conclusion, that consuming more sugar can raise the risks of cancer, especially breast cancer. Though we have come across many doctors stating that it doesn't matter what you eat after you are diagnosed with cancer, but the truth suggests the opposite. Along with tobacco, an unhealthy diet, and lack of exercise, a Western style diet is a major risk factor for many types of cancer.
Various researches also show that consumption of refined sugar is one of the few things which feeds your cancer, and makes it worse. Those patients who eat more sugary foods are more likely to have advanced cancer.1
But how does this work?
As we know that table sugar is composed of two sugars, glucose and fructose. Fructose is processed more by the liver, while the glucose in the pancreas. Studies show that cancer thrives on fructose; fructose is the driver of the tumorigenic process. Though any sugar can make your cancer bad, fructose makes it worse.
What are the foods that make your cancer bad?
Sweetened soft drinks are the largest single source of sugar in the Western diet. A WHO study says that we get no more than 5% of calories from sugar. Processed sugar kills a large number of people across the world every year than we can imagine.
So the solution to the problem? Switch to fruits for natural sugars and a nutritious meal. You will find that almost all the fruits ward off some or the other kind of cancer for sure.
So what are you waiting for?
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Picture Japan: Inside Fukushima Daiichi
Tokyo Electric Power Co. on Tuesday released grainy but vivid stills from a video taken on May 6 that illustrate the steps being taken to resolve the crisis at the Fukushima Daiichi nuclear power plant.
Japan unveiled new plans on Tuesday to contain the crisis at the crippled nuclear plant after admitting it faced greater challenges than first disclosed, but kept to its goal of bringing the reactors under control by January.
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Professor of Religion
Chair of Religion Department
Kanbar Hall - 111
Robert Morrison
Begins by showing how Judaism, Christianity, and Islam in the modern Middle East are intertwined closely with politics and with their local contexts. Case studies include modern Iran, Israel, and Lebanon. Investigates how the foundational texts of Judaism, Christianity, and Islam were politically and socially constructed. Considers throughout the influence of other Middle Eastern religions.
Robert Morrison
Surveys the history of science, particularly medicine and astronomy, within Islamic civilization. Pays special attention to discussions of science in religious texts and to broader debates regarding the role of reason in Islam. Emphasizes the significance of this history for Muslims and the role of Western civilization in the Islamic world. Students with a sufficient knowledge of Arabic may elect to read certain texts in Arabic.
Robert Morrison came to Bowdoin college in August, 2008. His courses lie in the academic study of both Islam and Judaism, but address, in addition, comparative topics. His research has focused on the role of science in Islamic and Jewish texts, as well as in the history of Islamic science. Robert has contributed the chapters on Islamic astronomy to the New Cambridge History of Islam and the Cambridge History of Science. He was previously a faculty member at Whitman College (in Walla Walla, WA) from 2001-8.
The Intellectual Career of Niẓām al-Dīn al-Nīsābūrī (Oxon, UK: Routledge, 2007); 301 + viii pp. Awarded the 2009 World Prize for the Book of the Year of the Islamic Republic of Iran in Islamic studies.
Astronomy in al-Andalus: Joseph Ibn Naḥmias' The Light of the World. University of California Press, 2016.
"Quṭb al-Dīn al-Shīrāzī's Hypotheses for Celestial Motions," in Journal for the History of Arabic Science XIII (2005): 21-140
Co-edited Book
Texts in Transit in the Medieval Mediterranean
"Conceptions of the Soul in Abraham Ibn Ezra's Poetry"
Edebiyat XI (2000): 239-59
"The Portrayal of Nature in a Medieval Qur'an Commentary"
Studia Islamica XCIV (2002): 115-38
"The Response of Ottoman Religious Scholars to European Science"
Archivum Ottomanicum XXI (2003): 187-95
"The Role of Portrayals of Nature in Medieval Qur'an Commentaries"
Arabica LII (2005): 182-203
"The Solar Theory of Joseph Ibn Nahmias"
Arabic Sciences and Philosophy XV (2005): 75-108
"Science and Theodicy in Q 2:6/7," in Jitse M. van der Meer and Scott Mandelbrote (eds.): Nature and Scripture in the Abrahamic Religions (Leiden: E.J. Brill, 2008)
"Discussions of Astrology in Early Tafsīr," Journal of Qur'ānic Studies XI (2009): 49-71
"Islamic Astronomy and Astrology," in Robert Irwin (ed.) New Cambridge History of Islam (Cambridge University Press, 2010), vol. 4: pp. 589-613
"Islamic Astronomy and Cosmology," in David Lindberg and Michael Shank (eds.): Cambridge History of Science, vol. 5 (Cambridge University Press, 2011): 109-138
"An Astronomical Treatise by Mūsā Jālīnūs alias Moses Galeano," Aleph: Historical Studies in Science and Judaism X/2 (2011): 315-53
"Natural Theology and the Qur'ān," Journal of Qur'ānic Studies XV (2013): pp. 1-22
"What Was the Purpose of Astronomy in Ījī's Kitāb al-Mawāqif fī 'ilm al-kalām?" in Judith Pfeiffer (ed.): Tabriz after the Mongol Conquest (Brill, 2013): pp. 201-29
"A Scholarly Intermediary Between the Ottoman Empire and Renaissance Europe," Isis (3/2014): 32-57
ISIS and Islam: A Conversation with Bowdoin's Elias and Morrison (VIDEO) (December 16, 2015)
"Uncomfortable Voices," 2015 Convocation Address (September 3, 2015)
Bowdoin Islamicist Wins Top Iranian Book Prize (February 19, 2009)
New Faculty Scholar Deepens Study of Islam, Judaism (August 29, 2008)
Wiegand Memorial Lecture at University of Toronto, 2011
Big Ideas: Robert Morrison on Islam and Science
Comparative Theology lecture at Harvard Divinity School on Islam and science, 2013
What Can the Christian Category of Natural Theology Tell Us About Islam?


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Reduce flinching instantly by reducing recoil up to 70% with this easy-on, easy-off pad. Use for hunting or target shooting. It will not harm your stock, won't harden in cold weather or become brittle with age, and takes the sting out of even the hardest kickers. - $19.88