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WB: Rains lash Kolkata; waterlogging, traffic jams in many areas
Many schools and colleges remained closed owing to the incessant rains that continued since Tuesday.
Kolkata: Heavy rains on Wednesday disrupted normal life in Kolkata after various parts of the city have been waterlogged following incessant rains. Traffic movement and train services have also been partially hit at the Sealdah station.
"Heavy to very heavy rains will occur at isolated places in Gangetic West Bengal till Thursday noon," regional MeT director GC Debnath said on Wednesday. Though the weather may temporarily improve in the metropolis and adjoining areas tomorrow afternoon, it is likely to continue to remain bad for the next two days in South Bengal, Debnath said.
A well-marked low pressure concentrated into a depression over Gangetic West Bengal and adjoining northwest Bay of Bengal, north Odisha and Jharkhand and lay centred at about 150 kms southeast of Jamshedpur and 150 kms south-southwest of Bankura, according to the MeT department.
The system would move gradually in a west northwestward direction and weaken into a well-marked low pressure area during the next two days. The metropolis experienced 91.6 mm rainfall in the since Tuesday till this noon, MeT sources said.
While several low lying areas in different parts of the city and adjoining areas were inundated, water receded fast in the main thoroughfares, reducing the woes of people going outdoors.
Many schools and colleges remained closed owing to the incessant rains that continued since Tuesday and a good percentage of office-goers also decided to remain indoors. Public vehicles were lesser in number on the streets due to the inclement weather. There was, however, no mishap related to the heavy downpour, city police sources said.
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Call us at 317-867-2737
Since 2001, CSI Signs has produced quality customized sign solutions such as custom banners, for clients in and around Indianapolis. From small businesses to large corporations, CSI Signs creates custom signs for all types of businesses and organizations. At the core of our company are honest, friendly and hard-working individuals who strive to provide our customers with top quality custom car decals, vehicle wraps, trade show displays and much more!

subset: commoncrawl


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April 9, 2013
Notes Packet | Saturday Fan Guide | Victors Trio Details
Coach Paul on WTKA Insider
Saturday, April 13 -- vs. No. 13 Ohio State - Battle at the Big House (Michigan Stadium), 3:30 p.m.
Follow the game: Free Admission | Live Video | Live Stats
The University of Michigan men's lacrosse team (0-11, 0-5 ECAC) will take on the No. 13 Ohio State Buckeyes (7-3, 2-2 ECAC) Saturday (April 13) in the second Battle at the Big House at 3:30 p.m. inside Michigan Stadium. The matchup follows the annual U-M Spring Football game, which commences at 12:30 p.m.
The game is part of the Victors Trio. Fans that go to the football, men's lacrosse and baseball games this Saturday receive one $5 M-Den gift card, one free hot dog & one free hot chocolate and one entry to win two tickets to the Michigan vs. Notre Dame football game next season.
Kyle Jackson continues to lead the team in goals with 13 and in points with 20, while Mike Hernandez leads the assist category with eight. Both Hernandez and Jackson also pace the team in shots, as Jackson has 64 to 53 for Hernandez. Gerald Logan leads the team in ground balls (28), while Chase Brown has caused 11 turnovers to lead the squad. Sophomore Will Meter has a point in seven of the 10 games he has played in this season (8g, 4a) and has tallied at least one point in 22 of the 26 games he has played in during his Michigan career.
Against Delaware (April 6), two players, Evan Glaser and Tom Sardelli, had their first goals in Maize and Blue. Glaser is a freshman, and Sardelli is a transfer from Sacred Heart who arrived prior to the 2013 season, giving U-M 13 players with at least one goal this season. Michigan's three-goal fourth quarter output tied a season best; the number was previously set against High Point (March 6).
Logan had 15 saves against the Blue Hens to mark the seventh game this season he has stopped at least 15 shots, and he holds a save percentage of 57 to go along with 169 saves. He leads the nation with 15.36 stops per contest and is No. 2 in total saves.
He established a new program record with 25 stops against Army on March 2 in Miami. It is the top save number in the NCAA this season. For his efforts, he took home ECAC Rookie of the Week honors. He was the second Wolverine ever to win the award, as Emil Weiss earned the award last year. Logan tied the previous record with 19 stops against Penn State (Feb. 9), keeping U-M in the game in an 11-6 loss.
The Wolverines have played the 20th-most difficult schedule in the country thus far, according to LaxPower.com. U-M has squared off against a trio of ranked opponents in No. 13 Penn State, No. 4 Johns Hopkins and No. 6 Loyola. Ohio State will enter the contest as the No. 13 team in the country. Following the Ohio State matchup, U-M's final ranked opponent will be Denver, which currently comes in at No. 3 in the poll.
In the 10-6 loss against Air Force (March 30), U-M outshot the Falcons by a 37-36 margin and beat them 29-28 in ground balls. It marked the first time this season the Wolverines have won a ground ball battle and the second time they have outshot an opponent (Colgate). Three players accounted for the six scores, as Jackson, who had a career-high 12 shots, joined Meter and Hernandez with two scores apiece. Freshman Evan Glaser earned his first career point in the contest, assisting on a Jackson goal in the fourth quarter. U-M also tied a season high with 11 caused turnovers, matching its total against Penn State (Feb. 9).
Michigan's man-down and man-up units have excelled this season, as the Wolverines are killing off 76 percent of opponent opportunities, allowing eight goals in 34 chances to rank No. 3 in the conference. U-M is No. 4 in the ECAC in man-up goals with 11, scoring on 28 percent of its chances.
The loss against Johns Hopkins (Feb. 23) featured U-M going up against the No. 4 Blue Jays, the highest-ranked opponent U-M has ever faced. After being outscored 11-3 in the first half, U-M rallied in the second stanza and was outscored by a 6-5 margin. Michigan is now 0-7 against ranked opponents all-time and has been outscored by a 105-44 margin against those opponents.
Freshman Brad Lott is 72-of-162 in faceoffs this season, good for a 47.5-percent mark and No. 49 nationally. The No. 1 faceoff specialist in last year's recruiting class according to ESPNHS, he went 25-of-40 at the X (63 percent) during Michigan's road games against Fairfield and Colgate (March 14-17).
U-M went 17-of-17 on clears against Colgate (March 17), marking the first time in program history the Wolverines were perfect on clears in a contest as a varsity program. It is also believed to be the first time a team coached by John Paul has gone perfect in the clearing game dating back to the team's club lacrosse days. In total, U-M is clearing at an 83.9-percent success rate this season.
The Metropolitan Lacrosse Classic (March 17) featured Holy Cross vs. Navy followed by Michigan vs. Colgate at Citi Field, home of the New York Mets. The attendance number of 15,656 is the 26th-most fans to ever watch regular-season NCAA lacrosse. The Metropolitan Lacrosse Classic was the second men's lacrosse event in history played at a Major League Baseball stadium. The first was Navy vs. Johns Hopkins in 1971 at the Houston Astrodome, then the home of the Houston Astros.
Overall, 16 Wolverines have made their debuts this season, most recently Brendan Riefberg and Kevin Wylie against Hobart (March 9). Five newcomers have found themselves in the starting lineup for U-M: sophomore Mike Francia, junior Tom Sardelli, and freshmen Gerald Logan, Kyle Jackson and Mike Hernandez. Others who have played their first games for the Wolverines include Paxton Moore, Chris Walker, Charlie Keady, Dan Kinek, Sam Martorella, Chase Brown, Brad Lott, Riley Kennedy and Peter Kraus.
|Will Meter
Beverly Hills, Mich.
Q: You have been one of the most consistent offensive players for the team since forming as a varsity program. What do you attribute that to?
A: I think that this comes from being one of the few freshmen that were called upon to have a significant role in the first season at the varsity status last year. It was not always consistent, but being in this situation was a great learning experience, and it helped me mature on the field right away. After last year, we graduated our two offensive captains, and this forced some of the younger but more experienced guys, such as myself, to step up in a big way. Although only a sophomore, there are times this year that I am the oldest guy on the field, and being placed in this leadership role has really forced me to step up and be more consistent.
Q: Talk about the Ohio State rivalry. What is it like playing in the second Battle at the Big House?
A: The Michigan/Ohio State rivalry is unlike any other in sports. It is the one game that both teams circle at the beginning of their seasons. This is the biggest game of our season, and therefore there is always something different about Ohio week. Having the opportunity to play in the second ever Battle at the Big House is a great honor for all who are involved. There is such a rich history with the Michigan/Ohio State rivalry in all sports, and everyone understands that the lacrosse rivalry will grow to that point one day. We are some of the first people to ever take part in this rivalry, and it is something that we will certainly never forget.
Q: What are your family connections to U-M?
A: I have very strong family connections with the University of Michigan and the athletic program in general. My uncle, Jerry Meter, was a linebacker for the great Bo Schembechler from 1976-1978. In his senior season, he was elected co-captain, and recovered the fumble in the famous phantom touchdown play during the 1979 Rose Bowl. He would later return as an assistant coach for the Wolverines for eight years.
Q: The team is heading into the final stretch of the season. What are you looking to get out of the final contests of 2013?
A: Although there are only four games remaining in our 2013 season, we still have an outstanding opportunity in front of us. As I alluded to earlier, the Ohio State game is the biggest game of our season, and a win against the Buckeyes would change our entire season. We have been so close throughout the entire season, and in every game we are just off in one area. As a team, we are looking to put together some complete games and finish our season off on the right foot with a couple of wins for Team Two.
Q: Yourself, as well as several other teammates, met Mike Tyson in the airport on the way home from Delaware. What was that experience like?
A: It was crazy meeting Mike Tyson at the Detroit Airport. We had just landed and a few of us were headed to baggage claim to meet up with the rest of the team. As we were walking we were kind of caught off guard as we looked up and saw Mike quickly passing us. To our surprise, he stopped us and asked what team we were apart of, and thankfully he was willing to pose for a picture with myself and a few other teammates.
Ohio State enters the contest with a 7-3 overall record and is 2-2 in ECAC play. Most recently, the Buckeyes knocked off Hobart on April 6 by a 10-6 score. The Buckeyes have started the season off with a 4-0 record and have alternated wins and losses over the last six contests. OSU is 1-3 against ranked opponents this year, beating No. 11 Penn State, 10-9, in overtime on March 2.
Offensively, the Buckeyes are led by Teewaraton Trophy candidate Logan Schuss, who has 22 goals and 14 assists for 36 points, which leads in all three categories. Schuss is also No. 2 in the ECAC in man-up goals with five. Freshman Carter Brown, one of the favorites for ECAC Rookie of the Year along with Logan, is second on the team in goals (16), assists (13), and points (29).
Trey Wilkes is the man at the faceoff dot for the Buckeyes and is No. 3 in the ECAC in the category at 57 percent (95-73). The goalie spot is in flux, as Scott Spencer stepped up and beat Hobart in the team's most-recent contest against the Statesman, making 12 saves in the win. Greg Dutton started the nine previous contests, making 80 saves and holds a save percentage of 52. The team also boasts a superior close defender in Joe Meurer, who has 19 ground balls and has caused 14 turnovers.
Ohio State enters the game in the driver's seat to earn the Creators Trophy, which is decided between the three men's lacrosse programs at Big Ten Conference schools -- Ohio State, Michigan and Penn State, with the school that goes 2-0 claiming the prize. OSU is 1-0 with a win over defending champion Penn State, while the Nittany Lions were 1-1 with a win over Michigan earlier this season.
Last season in Ann Arbor, the Wolverines were downed by the Buckeyes, 12-9, on April 14, 2012. Senior Alex Vasileff tallied a trio of scores, while classmates Trevor Yealy and Brian Greiner scored twice. Goalie Emil Weiss made 12 stops in net. Ohio State led by as many as five goals in the fourth quarter and closed the gap 12-9 prior to the final whistle sounding. Schuss had three goals and two assists for five points, while Dutton made nine stops in the win.
Saturday, April 17 -- vs. Detroit (Michigan Stadium), 7 p.m.
» Beginning with the 2017 season, entry to regular-season home events will be free of charge..


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Trevor Siemian Post-Practice
Purple Wildcats Top Stories
The Opening Finals 2017 Official RosterThe official 2017 roster of the Nike+ Football The Opening Finals featuring the participants selected from The Opening Regional camp stops...
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Scout FootballYesterday at 7:00 AM
Broncos On The Brink: Bennie FowlerChad Jensen is spotlighting young Broncos on the brink. But are they players on the brink of stardom or obscurity? Today, we focus on wideout Bennie Fowler.
Mile High HuddleYesterday at 5:59 AM
4-star power forward eyeing June visitsFour-star 2018 power forward Race Thompson discusses his recruitment, where Indiana stands with him and what schools he's looking to visit in June.
Peegs.comSaturday at 9:44 AM


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Sliding Puzzle
by: BO Software • 9
All Android applications categories
by: BO Software • 9
This is a classical sliding puzzle game. It consists of a puzzle that has been divided in N x N tiles that have been shuffled. One tile is taken out and the tiles are shuffled. The objective is to move the tiles using the empty tile space in a specific sequence to rearrange the puzzle into its correct original order.
This application allows the user to pick among several puzzle images, the number of tiles (3x3, 4x4 or 5x5) and the difficulty level (easy, normal or hard).
You can do that by going to the menu and selecting the "New Settings" option.
At anytime you can restart the puzzle using the same puzzle settings by clicking the refresh button icon on the top right corner of the screen. You can also enable or disable application audio at all times by toggling the sound button on the left of the refresh button.
The application keeps track of the total number of moves made and the total amount of time taken to complete the puzzle. A guide checkbox will toggle the labels of the correct order of the puzzle tiles. You can compare with the labels on the reference small image at the top left corner of the screen.
Anytime the puzzle game is paused (back button or home button pressed or another application interrupts the current puzzle), the order of the puzzle as well as the progress so far is retained. Whenever you launch the puzzle application again, you will resume exactly where you stopped with the same order, number of moves and timer.
Every time you complete the puzzle and you achieve a high score, you are eligible to add it to the top scores also accessible via the "Top Scores" option in the menu.
Finally, a fun "Auto Solve" feature was added to the menu to have the puzzle solve on its own automatically.
Overall this is a great time killer and a good brain exercise.
I hope you enjoy it!
Tags: sliding puzzle , sliding puzzle number of moves 15
from 9 reviews
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Inquisition Tuesday: Working with Children
A friend of mine sent me a message I wanted to share here to spark some discussion.
I've been thinking a lot lately about childcare and working mothers. It just strikes me that of all times in history, I think this is the time in history where women have more "opportunities" but less opportunity to actually be women. We have more access to jobs similar to men, but we have to work like men, when it's not necessarily in our nature to do so. This is why you see so many women make the choice to be stay at home moms, because they don't want to be away from their children at this important stage of development. But why should that be the only choice they have? It seems to me that through the ages, women who have worked have worked with their babies and children right along side them, and there is something broken now that has brought us to a place where that can't be done. You're a feminist, but to me, a feminist the way feminism should be, fighting for the rights of mothers, not just trying to get us to be able to be men. And it strikes me that this is the logical next step. Why should people have to choose to stay at home to be with their children? Why can't women work with their babies? I'm really interested to hear your thoughts on this, especially having children, since I don't have a great idea of how the every day aspect of it would go. Anyway, I just think it is worth starting a discussion about, and getting the idea out there, so that more people can join the discussion and find solutions that would work for different situations.I have lots of thoughts on this issue. I think it depends on the job and the baby/child. Babies are very portable and I think many workplaces can accomodate a baby. Blacktating wrote about this and included at picture of Licia Ronzulli with her baby in a wrap. And even when her daughter was older, she brought her to work. There are obvious safety concerns in some workplaces, but a baby in a wrap could be feasible in probably a lot more situations than we think. Mail carriers, many retail associates, lecturers, and many more could wear a baby, especially if the baby was sleeping or nursing. As a child gets older and more mobile, that might be a little more difficult, but even kids Isaac's age (2.5) enjoy back carries. And if you work with other people who have small children, you might be able to set aside and block off a room or area for the small kids to play or set up an on-site daycare. Where I live in Oakland/Berkeley, there is an art space for moms to work on their projects and can bring their children along with them called Hackermoms. Small babies are free in the space and older kids cost a little for the babysitter. It's a great idea and everywhere needs a place like that.
And lest this seem like only a problem for small children, you can't really leave kids at home alone until they are 11 or so. For more than a decade, if your work schedule means weekends, you homeschool, or if your kids have holidays or vacations from school, you need to find supervision or watch them yourself. If you have to bring a 9 year old to work, she can probably keep herself occupied or even help out with small things like sweeping or washing windows (though... I guess you need to be careful about child labor laws). When I was a preteen, my dad would take us to work occasionally and I vacuumed and cleaned the microwave and other odd jobs.
For what I do right now, I either bring my children with me when I go help moms breastfeed, have the mom needing breastfeeding help come to me, or bring my work (knitting) with us to the parks or classes. Some design work and my own classwork needs a computer, so I have to do that work at home. McKay and I have been discussing options of me working outside the home in the future and depending on schooling options for the kids, I might seek out support groups for homeschooling and working or other transportation options for local schools.
I think society needs to be less childist and learn how to be patient with people who are learning how to speak and understand their emotions, who walk at a slower pace than most people, and who need to be taught about how to interact with people. Kids don't need to wait until they are 16 to learn how to talk to customers and sales people, or where money comes from and how to manage it.
It wouldn't would for every situation, but I think it'll work for many more than we think.
Some other reading:
PhDinParenting: Adult privilege is exacerbated when children are a minority
HoboMama's Two part post on having a home business with kids, part 1, part 2
What do you think? Do you think you could bring your child to work? What changes would need to be made for that to happen? If those changes happened, would you take advantage of them?
And if you know of good articles or posts on this topic, share those as well!


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UserVoice brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 97 Designs von 24 Designern wurde eine Gewinner gewählt.
UserVoice is the premier online feedback and idea generation tool being used on the web today. Having launched in 2007, we are at a point where we are looking to step up our company brand and would love to start with a new logo.
Our users are anyone with a website, from small startups to large enterprise companies. We also work with Government agencies and Nonprofits. Anyone who wants feedback and ideas, can use UserVoice.
We are looking to "revamp" our current logo utilizing the same Bullhorn theme (not the same bullhorn) and colors. The design should be simple and sleek, yet elegant. This is probably the easiest $150 you could make, as it is a simple redesign.
Please only submit original artwork.


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Rob R. wrote:What did you chose for cylinder heads?
freetown fred wrote:what a cute word--"TRICKS"-- I came up with two better ones
SMITTY wrote:Well so much for my leftover Subway grinder. ..............................
Was planning on eating it for supper tonight. It was in my cooler tucked away in my luggage box during the ATV excursion -- apparently an ice pack & constant bouncing are a bad combo ....
Rick 386 wrote: so I carried a full quart of 2 cycle oil in the back as a spare
Rob R. wrote: The switch was from the pre-Romex era, so I'm guessing it was 50-60 years old.
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"I confided in total strangers all over the world," he offers by way of excuse. "I was dealing with people who aren't experienced. This isn't their life's work. They aren't trained actors."
Joey Skaggs, is, of course, the Joey Skaggs, the most accomplished hoaxster of our time. Two years ago, he convinced CNN and countless other media organizations that he had developed a computer program, named the Solomon Project, that could replace human juries. Before that, he fooled reporters into believing he was a Korean-American businessman offering to buy animal-shelter dogs for his cannery. Before that: an American Indian doctor who transplanted people's scalps to treat hair loss.
For the past 30 years Skaggs has been assembling hilarious hoaxes that have made fools of journalists, poked fun at cultural conceits, and generally provided a good time for Skaggs fans around the world. His Web site, produced by San Francisco's Maria Marchetti, details a third of a century of sublimely fraudulent genius. He's been profiled in The New Yorker, The New York Times Magazine, and other print media, and been a guest on Entertainment Tonight, Geraldo, and other television shows -- often represented by an impostor stand-in.
But Skaggs' latest effort, a complicated prank called "Stop BioPeep," suggests he's in a slump.
Skaggs distributed press releases worldwide a couple of months ago representing himself as Dr. Joseph Howard, an Australian conspiracy theorist hot on the trail of governments and corporations secretly planning to alter the genetic code of the human race. The release claimed spiked soft drinks would be distributed at the Sydney Olympic Games, targeting consumers' DNA to make them crave certain brand-name products.
Since we're fond of absurd conspiracy theories, after reviewing Skaggs' press release, we bit. The purported conspiracy-buster, Dr. Joseph Howard -- aka Joey Skaggs -- responded to our e-mail inquiry with a detailed reply inviting us to contact evil conspirators in Hawaii, Santa Fe, and Slovenia.
We called a telephone number in Hawaii that Howard claimed belonged to publicist Warren Dastrup, of the blandly sinister-sounding Pacific Research Associates.
"Err, how did you get my name? I'm not at liberty to talk about that right now," Mr. Dastrup said, before we managed to get a word in edgewise.
So we passed the phone to investigative reporter David Pasztor, who placed a second call to Mr. Dastrup.
"Err, how did you get my name? I'm not at liberty to talk about that right now," Mr. Dastrup said. Hawaii's telephone company described Dastrup's number as belonging to a residential address.
Disappointed, we went back to doing real work.
Skaggs explains that he was on vacation in Australia when he and some pals cooked up the genetic spiking scenario, then recruited more friends around the globe to help them pull it off.
But nobody seems to have bitten, with the exception of a few newspapers in Slovenia, where Skaggs had a cohort who helped perpetrate the prank. "The news media was going nuts in Slovenia," boasts Skaggs. "There's this big daily news-paper in Slovenia that wants me to go talk with them."
Slovenia? Joey Skaggs, court jester for a generation, is reduced to picking on journalists from a country with only four years of free press to its credit?
Skaggs claims his mistake was depending on those untrained in the art of quality hoaxing -- Mr. Dastrup for example. Though Skaggs scheduled an elaborately planned phony protest march in New York on the same day as President Clinton's State of the Union Address, he got paltry U.S. coverage.
In his own defense, Skaggs says he considers the BioPeep prank a success, because, like his other gags, it caused people to ponder issues of great import in today's changing world.
"STOP BioPeep was a complex performance piece that touched on many issues that face humanity and that deserve serious contemplation," he wrote in a follow-up press release.
We're still hoping Skaggs will return to simple, elegant, brilliant pranks, like his classic "Cat House for Dogs," a phony canine brothel where pet owners took randy dogs for relief at $50 a pop. Or "Fat Squad," in which he conned his way into an appearance on Good Morning America by claiming to be the owner of a company that kept people on their diets using physical force.
After all, Joey Skaggs fans don't need civics lessons. We need hoodwinked talk-show hosts, preposterous falsehoods perpetrated as truths, absurd lies crafted into national headlines.
We need Joey Skaggs, keeping ushonest.


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A Family in Bloom Adoption is a licensed, Hague Approved International and Domestic Adoption Agency in Colorado. We help create and grow families through domestic and international adoption. Our mission is to accomplish this goal through quality personalized service, with a commitment to high ethics and financial integrity. Central to the agency's philosophy is the belief that every child deserves a loving, secure and permanent family. Respect, care and understanding are integral to our work with birth parents. The agency works with any applicant, birth parent or adoptive child regardless of race, ethnicity or national origin.
A Family in Bloom Adoption facilitates adoptions in many countries throughout the world through one of our agency's own established country programs or by acting as Primary Provider in others where there are few options otherwise for international adoptions.
Our agency offers international adoption programs in Nicaragua, Uganda, Bulgaria, Jamaica and Nigeria. Some of the countries where we have acted as Primary Provider are Cameroon, Benin, Ghana, Zimbabwe, Iran, The Philippines, Bangladesh and multiple Caribbean nations.
Within the US, A Family in Bloom Adoption has experience with different kinds of domestic adoptions with a Domestic Infant Program, waiting children from the adoption exchanges, designated adoptions, second parent adoptions and kinship adoptions. We are licensed for adoptions in the age range of 0 to 18 years. Children with special needs can be placed by the agency.
To learn more about our adoption services, please contact us.


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I'm doing some remodeling for my SIL. She has become disabled and has to use a wheel chair. Her house has a small bathroom and the location of the lavatory makes it necessary to use a shallower than standard cabinet.
I will take care of building The cabinet and doing the install. MY problem is trying to find a small vessel sink about 12 to 13 inches in diameter or a oval one that the narrow measurement is 12 or 13 inches. Any one know of any that will fit the needs of this project.


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Filled with in-depth insights, practical examples, and a number of anecdotes, Commodities Rising is an invaluable informational resource for today's serious investor or trader.
Written in a straightforward and accessible style, Commodities Rising analyzes the current commodity environment and looks out over the next few years to identify potential profit situations for investors and traders. More importantly, it will show you how commodities can be used to reduce risk and increase returns in a balanced investment portfolio. You'll be introduced to a variety of ways in which you can gain exposure to commodities - through both direct and indirect means - as well as discover some specific strategies that will allow you to use the instruments you choose effectively and manage your positions with confidence.
Commodities Rising also works hard to debunk much of the misinformation currently circulating about this market, and provides a reasoned and authoritative reality check. Some of the more widely circulated myths are addressed, including the concept of a long-lasting supercycle in rising commodity prices and the idea that China will be a massive consumer of commodities whose actions will drive prices even higher.
The second half of this book takes a deeper look at sixteen specific commodities grouped under the following headings:
- Precious Metals: gold, silver, platinum, and palladium
- Energy: petroleum, natural gas, and uranium
- Tropical agriculturals: cocoa, coffee, and cotton
- Grains: corn, soybeans, and wheat
- Base Metals: copper, lead, and zinc
Each chapter includes critical background information needed to assess the attractiveness of these individual commodities as investments.


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Sold out for 2016. Check back again in Summer 2017 for a new delicious blend!
Composed of coffees hailing from the major coffee regions of the world, the Summer Blend is a medium to medium dark roast that has perfect balance for summer!Cold-brewed coffee is one of the best ways to enjoy coffee, especially in the summer!
Here's how to make it:1. Place 2 rounded tablespoons of ground coffee per 8oz cup into a French Press.2. Add fresh COLD water (filtered or bottled water is best) and stir well.3. Cover and refrigerate overnight (or for at least 12 hours).4. Plunge coffee and serve, adding milk and sweetener to taste.For a great dessert, try adding some of your favorite ice cream and blend to make the perfect iced coffee milkshake! You can experiment with the amount of coffee - if it's not strong enough, try adding more coffee a little at time. If it is too strong, you can use less coffee or dilute with cold water to taste.
I am loving the summer blend! It is fantastic hot as well as cold-brewed in a French Press.... Yummy!
A good, strong coffee flavor with a distinctive taste. The taste is smooth.
I love the rich but mellow flavor of this coffee. It is a great afternoon coffee with absolutely no bitter aftertaste. I think that I would drink this year round.
I cold brew a large pitcher of Summer Blend weekly. It is light and flavorful. Wish it was available year round.


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|23rd November 2007, 02:52 PM
diyAudio Moderator
Join Date: Oct 2002
Location: Chicagoland
Blog Entries: 2
Daan, if I were to guess, I'd guess that Sound Lab's film supplier is using one of the fluorocarbon-based extrusion process aids like Dyneon. These are added at very low quantities and end up mostly on the surface of the film in (indeed) micro quantities. It's nothing unusual, I even use those process aids in extruding wine corks, but, hey, it's a feature.
As I said, it's just a guess, but I've gotten a bit cynical about technology claims in high end audio and have seen that kind of puffery over and over again.
"You tell me whar a man gits his corn pone, en I'll tell you what his 'pinions is."
|8th April 2009, 02:24 PM
diyAudio Member
Join Date: Mar 2007
Sorry to resurrect this topic, but I'm researching coatings, and specifically suitability for a high humidity, and dusty environment. Indeed, whether ESLs are suitable at all in high humidity (daily swings from 40-50% to 80%, and frequently to 95-100%).
The options I see discussed are:
1) graphite power
3) hand soap, etc
4) elvamide (nylon in alcohol), or calaton as used originally by Quad
5) EC-coating (what is this, and where can I get it?)
6) Licron
I appreciate there are all kinds of other possibilities, which have been raised in this thread, but I'm looking for a proven solution, if I go ahead with a regular ESL (probably a hybrid using eggcrate and wire, crossed at 200-300Hz).
Also, for membrane, 12u (microns) or thinner mylar or hostaphan seem to be the recommendation with 6u, 4u, and lower mentioned as preferable, and saran also a possibility but not recommended. However, I see shackman are using a polypropylene film rather than PET. Are there better film choices than mylar now?
On ESL design, I've been doing plenty of reading, and the standard ESL approach is to bias the membrane, and put the audio signal on the stators, out of phase with each other. However, there is another way, used by Beveridge, which is to put the audio on stators AND membrane. This way seems to have plenty of merits, especially re: dust, etc.
Is there a reason ESL's follow the "static membrane" pattern? Even the reverse, ie biasing high-resistance stators, and sending the signal to a low-resistance membrane seems better for dust, etc.
The Beveridge stators appear to be a mixture of carbon and epoxy, with a foil backing on the outside; away from the membrane. Not entirely dissimilar to a PCB, in seems. Has anyone experimented with a DIY version of the Beveridge approach? I know he states in a thread that their method is not suitable for DIY, but I think their life production is only a few hundred units, so they must be using relatively DIY, or at least, small-run, production techniques. Not meaning to rip anyone off (I can't, and probably never will, afford $65k speakers), but I'm intrigued by their different approach.
|9th April 2009, 07:04 AM
diyAudio Member
Join Date: Nov 2004
Location: close to Basel
All the named coatings have been extensively discussed before and from this list the EC-coating should meet Your demands best, if not the only usable one.
Mylar and Hostaphan (at least certain makes of these) are the best materials for diaphragms. I haven´t heard of a PP-material yet, that could hold the mechanical tension over a long time.
Any ESL applying the audio-signal to the membrane is of so called constant-voltage-type. Driving forces are highly non-linear and so distortion is high. It is only really usable at very small excursion levels, so maybe as Tweeter-panel.
Biasing the membrane and applying the audio signal to the stators leads to a constant-charge-type. Here the driving forces are highly linear and exceptional low distortion values are possible. Sonically its a vastly superior system.
To my taste the casted epoxy stators are very much DIY-style.
The clue behind these stators is the doping with a very high epsilon-valued doping agent to get a high-epsilon-dielectric. This allows for low voltage losses in the thick stator whilst lowering flashover problems by the sheer distance between conducting surface and membrane. As a sideaffect the high mass and strength of the panel should be work in favour too. It must be kept in mind though that a very smooth distribution of the doping agents is needed and that the voltage-current-relationships within the stator might not be linear anymore.
For a first step it might be much easier and more success-promising to use PCB-material and drill and etch a certain hole-pattern into this.
|9th April 2009, 03:18 PM
diyAudio Member
Join Date: Mar 2007
Thanks Calvin, yes I know this has been done to death, but there wasn't so much discussion about which, if any, coatings were suitable for high humidity.
About ESL design, I don't understand why it matters whether the stator, or the membrane is "active", so long as whichever surface has the varying signal has low resistivity? ie a "reverse" esl should be just as effective as a standard one, partcularly in the case where there is just a single stator. I think the Beveridge have both stator and membrane variable though, I don't fully understand the system.
I think I will follow your advice and look at a fairly standard design - there is plenty to read and think about just with that.
|10th April 2009, 07:30 AM
diyAudio Member
Join Date: Nov 2004
Location: close to Basel
the trick with a constant charge ESL is that it ´takes the membrane out of the electrical circuitry´. By this I mean, that the membrane is regarded as a ´piece of constant charge´. It wouldn´t need any electrical connection to a bias-supply or any other part of the electrical circuit at all. This is the case for so called electret materials which are used in electret microphones and electret Headphones.
The music signal which is connected out of phase to the two stators creates a homogenous electrical field between the stator-plates. This means that the force acting on a probe-charge is the same at any point between the stators! The system is perfectly linear as long as the stator plates remain fixed. The value of the charge has a influence on the forces acting upon the charge/membrane, but it can be shown, that this doesn´t effect the linearity of the system, but just creates a mechanical offset of the membrane off of the middle position.
If You change to a low resistance coating (constant voltage type) the membrane becomes an ´active part´ of the electrical system which is constantely charged and discharged. The forces acting upon the membrane are not linear any more since the membrane behaves like a moving stator itself. The forces vary quadratically with the distances of stator and membrane, hence non linearity, hence distortion. Distortions can only be kept small if the excursion can be kept very small.
The real expalanation is of course more complicated, but this should give You a rough idea.
|10th April 2009, 09:43 AM
diyAudio Member
Join Date: Jun 2006
Hi Jackpipe,
The coating I used successfully in Thailand is graphite powder. Humidity in Thailand is quite high all year round.
Wachara C.
|16th April 2009, 03:38 PM
diyAudio Member
Join Date: Feb 2008
ER Audio in Australia sells a proprietary conductive coating that works very well in high humidity conditions; although do not know of any ESL's that can stand up to near 100% humidity conditions for years on end without quirks.
Calvin gives you some excellent advice on ESL designs.
Good luck.
|15th May 2009, 08:01 PM
diyAudio Member
Join Date: Apr 2009
Does anyone have a comparison between the ER coating and the one that Martin supplies? What effect does altitude (if any) have
|11th July 2009, 09:25 PM
diyAudio Member
Join Date: Jul 2008
Hi folks,
A modern coating works fine forever in any altitude, moisture and applied voltage.
The progress in electro-chemical substrates is far beyond that what is discussed since decades, especially about that "Nylon Myth", and, on the opposite, the ESL63 kind of graphite coating with Nylon pre-base coating.
That was yesterday. Today we have coating substrates light-years beyond all those discussions. So why live in the past. Better refer to the latest science developments. At least we do so since very quite a while.
|12th July 2009, 10:30 AM
diyAudio Member
Join Date: May 2008
Location: Malmö
Reromanus, I understand that You make a coating that works, could it be possible to receive a free sample?
regards, Jonas
There are 10 kinds of people. Those who understand binary numbers and those who don't.
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At Furstenfeldbruck, a camp for displaced persons in Germany, Spellman began composing his Rhapsody in 1947. It comprised three sections: The first, a loud and martial passage meant to recall the brutal noise of war; the second, a quieter, piano-heavy passage conveying suffering; and the third, an upbeat, joyful movement. "We are liberated," Spellman explained, "and we start to sing Jewish life songs."
"I always dreamed that I have to survive the Nazis, Hitler, to tell the world what happened," he told David Hoffert. "I always say to myself, 'How did I survive this? I have no answer.'"
Listening to the piece was painful for Spellman, and when he and Mania and their young son Les immigrated to Canada in 1948, he put it away in his garage and moved on. (Along with a new life, the couple was given a new name, and their family surname Szpilman was anglicized for a Canadian palate.) Leo was reunited with his sister Chana, who had also moved to Toronto and remarried. Daughter Helene arrived in 1950.
After a brief stint as a dishwasher, Leo found his way back to a piano, founding the popular Leo Spellman Orchestra, which played more than 1,000 weddings and parties over the decades. He also had a successful sideline in property development.
Music and family were the constants in his life. He was charming and strong-willed but sometimes bossy, making the party guests when Helene turned 60 sing Happy Birthday a second time because they had been off-key. In the 1990s, Wronski, the student who had sheltered the Spellmans, tracked them down and they had an emotional reunion in Toronto.
But Spellman never opened the suitcase in his garage.
Then, in the late 1990s, the Holocaust Museum in Washington approached Szpilman about providing some music for Life Reborn, a conference for survivors and their families.
"I've never written Jewish music," he told them. "But my cousin Leo in Toronto did. You should try him."
In his garage, he found the work he had written half a century earlier, dusted it off and took it to Washington, where it had its North American premiere at the conference in January, 2000. "The reception was amazing," says Shifman, "and it meant so much to my father."
Over the next few years, Rhapsody 1939-1945 was performed in the United States to equally enthusiastic receptions, but never in Canada.
The fact that his composition had received no attention in his own country rankled Spellman somewhat, but he didn't dwell on it: An active man – he drove until he was 97 and lived on his own for two years after that – he had family and music to keep him busy. (He also spoke on the phone to Chana, now 105, several times a day.)
Still, his family – two children and seven grandchildren – nagged him to record Rhapsody, and to have it performed in Canada. Spellman finally caved and three years ago reached out to Hoffert, the award-winning composer and co-founder of the band Lighthouse, to see if his Holocaust composition might be captured for posterity.
"He made me audition," Hoffert says with a laugh. "He wanted to make sure he had the right guy. I understood that. I have high standards, too – you should if you're an artist and composer."
Hoffert realized, when he sat down to listen to Spellman play, what an incredible story the music was telling, and he was surprised it wasn't better known. "I thought how awful it was that here was this person who was a great artist, and nobody knew that he'd written major pieces of music in the 20th century."
He gathered musicians and, following the precise and rigorous instructions of its composer, began to record. (Spellman didn't play on the CD, but was more than happy to provide directions from the sidelines.)
Along with the record, Paul Hoffert and his wife, Brenda, began to make the documentary about Spellman's life, although speaking about the war was difficult. At one point, he wipes tears from his face with a handkerchief: "When I listen to the Rhapsody, I'm crying, because it reminds me of how I made this. I remember those years."
Spellman's health began to fail only in recent months. In September, he was well enough to attend the Canadian premiere of his composition, held as part of the Ashkenaz Festival in Toronto. After the concert, people lined up to buy the CD.
"My father's Rhapsody captured the enormity of this tragedy, and his own personal sense of sorrow and loss," Shifman says. "It became his healing."
Editor's note: An earlier version of this story incorrectly identified Brenda Hoffert as the wife of David Hoffert. Ms. Hoffert is the wife of Paul Hoffert. This version has been corrected.Report Typo/Error
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8680 SADDLEBACK CIR Park City, UT 84098
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Take advantage of this location on a quiet culdesac with only a few other homes and up against protected open space and build your own custom home with Icon Homes. They have provided an initial design for you to either use, change to meet your specific needs, or scratch it all and start fresh. Their design takes advantage of the spectacular westerly views with a huge deck overlooking the adjacent protected land. The design is based on the Scandinavian A-frame homes and utilizes the vaulted ceilings to provide both an incredible open concept living area and a master retreat second to none. Additional 2 bed 1 bath on the main floor as well as 2 bed 1 bath in the lower level make this design perfect for the growing family. Typical custom homes start at $200/sq. ft. Renderings have been completed on this home for marketing purposes only. Renderings may or may not be accurate. Products and specifications in renderings are not necessarily used in finished product.
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Information deemed reliable but not guaranteed accurate. Buyer to verify all information.The multiple listing information is provided by Wasatch Front Regional Multiple Listing Service, Inc. from a copyrighted compilation of listings. The compilation of listings and each individual listing are © 2014 Wasatch Front Regional Multiple Listing Service, Inc., All Rights Reserved. The information provided is for consumers, personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.


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Patriot girls beat Tigers in soccer 'friendly'
Andrew Grassey
When Tiverton High School girls soccer head coach Joseph Gill called Portsmouth High Schools head coach Jim Blaess to schedule a game between their teams, both coaches knew what to expect. For Tiverton, the hope was for a good test against a division one opponent. For Portsmouth, it was a chance to play some of their younger players who don't get too much playing time during their competitive season. With no impact on the record or standings for either team, the
purpose of the game was to build experience.
"When I scheduled the game it was to get us ready for the tournament because Portsmouth has a great team year in and year out," Gill said. "It will help us come tournament time so that is the main reason why we scheduled it."
Portsmouth won the game over Tiverton on Saturday night by a score of 3-0. The Patriots controlled the possession for the majority of the game, which led to many scoring chances.
"Our style of play is a possession style of play. The fitness level and fitness demands are much greater in division one," Blaess said. "We emphasize a lot of fitness and a lot of off-the-ball movement to keep things going."
Tiverton's sophomore goaltender Amber Silva was able to hold off the Patriots offense at bay with multiple saves early in the game. The closest chance came when Portsmouth senior Jessica Kaufman drilled a ball toward the corner of the goal but Silva was able to knock it away with her hands.
"Amber has been rock solid all year long," Gill said. "Ever since the beginning of the season, there have been games that we possibly could have lost but she has been solid and has really had a great season so far."
Portsmouth finally scored its first goal of the game 26 minutes into the first half when junior Kelley Coyne kicked one off the hands of Silva and into the net.
In the second half, Portsmouth was able to convert on a couple of chances early. The first came off a shot from Kaufman that was hit perfectly out of the reach of Silva and into the top corner of the net. The next goal came from senior Kristina Caragianis who, after having a goal taken away minutes prior because of a hand ball, was able to knock one into the net to give Portsmouth the 3-0 lead. Although Tiverton suffered the loss, Gill was pleased with his team's efforts.
"I thought we played pretty well," Gill said. "It's a friendly rivalry, it's not like there is any animosity."
Tiverton is hoping to get healthy again as they only played 13 of their 26 players on Saturday night because of injuries. On top of that, four of those 13 players usually play on their JV roster. This created an even greater challenge for a Tiverton team that was already playing a team from a higher division.
After Saturday night, both teams are now starting to get ready for playoff time. For Portsmouth, the aim is to get their players ready for the tournament and make a deep playoff run. Tiverton, on the other hand, still has to fight to make the playoffs as the team is on the bubble as of now. With only a few games remaining in the regular season, each game is crucial for both teams.


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With free-to-play models all the rage for aging and/or struggling PC MMOs, it's with little surprise we learn today that NCSoft and Paragon Studios have opted to go that route for one of the more popular MMOs of the last several years, City of Heroes. Though the game has maintained subscribers in the low hundreds of thousands over the last few years (around 125,000 as recently as earlier this year), the title, which originally launched all the way back in April of 2004, was probably due for a bit of a shake-up, and this new F2P model looks designed to do precisely that.
With the new model, any player can create a hero or villain and play all the way up to level 50 for free. That said, there are also Premium and VIP subscriptions that offer a bit more in the way of content for more dedicated players. Anyone who has previously paid for a City of Heroes account is automatically labeled a Premium member, and by jumping back in with the new game client, you'll retain all of the veteran rewards, super boosters, and other various things you've acquired over the course of your play time. New players can also become Premium members by purchasing any amount of Paragon Points, AKA the in-game microtransaction currency.
VIP players will still pay a monthly subscription fee, but will get free access to the Going Rogue expansion content, specific VIP servers, and also a monthly allocation of free Paragon Points to spend on whatever superheroic bric-a-brac their heart demands.
You can find a full breakdown of the different subscription models at the official City of Heroes website, if you're thinking about jumping back into the battle of good spandex versus bad spandex. Maybe now might be a good time to bust out my old villain, Captain MonkeyPants. He was quite the scourge, that one.


text:
News & Events
Testimony by Mark Al Elengold on Anthrax Vaccine Adsorbed, October 3, 2000
Statement of
Mark A. Elengold
Deputy Director, Operations
Center for Biologics Evaluations and Research
Food and Drug Administration
the House Committee on Government Reform
October 3, 2000
Mr. Chairman and Members of the Committee, I am Mark A. Elengold, Deputy Director, Operations, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA or the Agency). I appreciate the Committee's interest in the Anthrax Vaccine Adsorbed and the opportunity for FDA to update the Committee of the regulatory status of BioPort Corporation (BioPort), and the Agency's experience with adverse event reports for the anthrax vaccine. Let me assure you that we will continue to help ensure that only safe and effective products are marketed and that these products meet high standards of quality.
As previously stated before the Committee, anthrax is an infectious disease caused by spores of a bacterium known as Bacillus anthracis. Human infection may occur by three routes of exposure to anthrax spores: cutaneous, gastrointestinal, and pulmonary (inhalation). Breathing in airborne spores of anthrax bacterium may lead to inhalation anthrax. Experience has shown that inhalation anthrax has a very high mortality rate, with estimates ranging from 80 percent to 90 percent or higher. Prior to the use of anthrax vaccine, cases of human anthrax infection in the United States (U.S.) were much more prevalent. The only FDA approved medical prevention against anthrax is the anthrax vaccine. According to data from the Centers for Disease Control and Prevention (CDC), there were approximately 130 reported cases of anthrax infection per year at the start of this century.
The clinical trials on the anthrax vaccine were conducted by Philip S. Brachman et al., during the 1950's1 and CDC in the 1960's. The Michigan Department of Public Health (MDPH) (now BioPort) manufactured four lots of the vaccine used in the CDC study. On April 14, 1966, CDC submitted an investigational new drug (IND) application for anthrax vaccine to the Division of Biologics Standards, which was then part of the National Institutes of Health (NIH) and later transferred to FDA (now CBER). The Division of Biologics Standards determined that the data submitted by CDC supported licensure of the vaccine. On November 10, 1970, the Division of Biologics Standards issued a product license to MDPH to manufacture anthrax vaccine.
Based upon their review of available data, a 1985 Advisory Review Panel recommended that the anthrax vaccine manufactured by MDPH be classified as a Category I product (safe, effective and not misbranded) and that appropriate licenses be continued based upon substantial evidence of safety and effectiveness of this product. These findings were published in the Federal Register (December 13, 1985, Vol. 50, No. 240 p. 51002-51117).
There are also relevant non-human primate efficacy data. Previously, data had been provided to FDA indicating that anthrax vaccine protects non-human primates against a high challenge of inhalation anthrax with the Ames Strain (which is non-homologous, or dissimilar, to the vaccine strain). More recent data on animal efficacy was published in summary form by Arthur Friedlander, M.D., et al., in the Journal of the American Medical Association on December 8, 1999. This publication noted that non-human primates had a high level of protection against two more non-homologous strains, in addition to the Ames Strain. The Department of Defense (DoD) has committed to submit the new data to FDA under an existing IND.
There is currently only one FDA-licensed facility for the production of the anthrax vaccine. The MDPH originally operated the facility, which then was transferred to the Michigan Biologics Products Institute (MBPI), and finally, in September 1998, the facility was sold to BioPort.
FDA has inspected this facility on many occasions during the past decade, identifying a number of deficiencies requiring correction. In particular, FDA conducted a surveillance inspection of MBPI in November 1996. During that inspection, FDA investigators documented numerous significant deviations from the Food, Drug, and Cosmetic (FD&C) Act, FDA's regulations and current good manufacturing practices (GMPs). Based upon the documented deviations, FDA issued a Notice of Intent to Revoke (NOIR) letter to MBPI in March 1997. The NOIR letter did not mandate the closure of the facility or lead to seizure of finished product. The letter, however, did state that if MBPI's corrective actions proved to be inadequate, the facility would run the risk of license revocation. MBPI responded to the NOIR with a "Strategic Plan for Compliance" presented to FDA in April 1997.
In February 1998, FDA conducted a follow-up inspection of the MBPI facility to evaluate MBPI's compliance with its strategic plan. The February 1998 inspection disclosed significant deviations from FDA's regulations.
FDA also noted in the February 1998 inspection that MBPI had made progress in achieving its compliance goals, but additional work remains in order to correct the deviations related to the manufacture of the anthrax vaccine. Pursuant to its purchase of the MBPI facility in September 1998, BioPort agreed to abide by the strategic plan and other commitments for corrective actions made by the management of MBPI. During the October 1998 inspection of BioPort, FDA found continuing improvement.
FDA believes that the previously manufactured and CBER released products, not presently quarantined by BioPort, are safe and effective for the labeled indications. FDA found that the firm had made progress toward meeting objectives under its strategic plan in bringing the facility into full GMP compliance. Based on BioPort's progress to date, FDA is hopeful that the company will continue to demonstrate improvement. We will continue to work closely with BioPort to ensure that the goals outlined in their strategic plan are met.
It should be noted that MBPI halted production of anthrax vaccine sublots in January 1998, prior to MBPI sale to BioPort, to begin a comprehensive renovation of the anthrax production facility. Although there has been a resumption of manufacturing in order to produce lots in support of the license application supplement to include the renovated facility, no lots of anthrax vaccine manufactured in the renovated facility have been released.
Due to the rules of confidentiality, FDA cannot generally disclose details of, or even acknowledge the existence of, a pending application or supplement unless that information has already become public. In the case of BioPort, press reports and information made public by BioPort have disclosed various aspects about anthrax vaccine. Because the information has been made public, FDA can disclose that BioPort does have a pending supplement for renovations to their anthrax vaccine manufacturing facility. BioPort may not release product produced in the renovated facilities until this supplement is approved. FDA will generally assess manufacturing renovations by a review of a prior approval supplement and by performing a pre-approval inspection.
In order to examine the manner in which BioPort implemented the renovations to the manufacturing facility, FDA conducted a pre-approval inspection from November 15 through November 23, 1999. It should be noted that the November 1999 pre-approval inspection was more focused in scope and purpose from the February and October 1998 surveillance inspections. At the conclusion of the November inspection, BioPort received a Form FDA 483 with observations and possible deviations in some of the following areas: validation, failure to investigate, manufacturing deviations, deviation reporting, aseptic processing, filling operations, standard operating procedures, stability testing, and environmental monitoring. All observations on the Form FDA 483 must be addressed adequately before FDA will approve this supplement.
Because of the complex manufacturing processes for most biological products, each product lot undergoes thorough testing for purity, potency, identity, and sterility. The anthrax vaccine is subject to lot release. Before a lot of anthrax vaccine can be used, the manufacturer must submit a sample of the vaccine lot and a lot release protocol to the Agency. The lot release documents contain the results of the manufacturer's tests for potency, safety, sterility and any additional assays mandated by their license and a summary of relevant manufacturing details. FDA reviews the manufacturing and testing information provided in the lot release protocol and may elect to perform confirmatory testing on submitted samples. The manufacturer may not distribute a lot of the product until CBER releases it. The lot release program is one component of FDA's multi-part strategy that helps assure products quality.
No lots of anthrax vaccine manufactured in the renovated facility have been released.
Following FDA issuance of an approved license, there is continued post-marketing surveillance of the product by monitoring adverse events. For vaccines, this is accomplished through the Vaccine Adverse Event Reporting System (VAERS), which was initiated in 1990 and is jointly managed by FDA and CDC. VAERS receives reports from vaccine manufacturers, private practitioners, State and local public health clinics, and vaccinees themselves (or their parents or guardians). VAERS accepts all reports of suspected adverse events after administration of any U.S. licensed vaccine to individuals in any age group. Vaccine manufacturers, however, must report to FDA all reports of adverse events of which they are aware.
VAERS is a "passive" surveillance system. This means that it relies on health professionals, patients or guardians to submit reports of adverse reactions following vaccination. (An "active" surveillance system, in contrast, would follow all individuals in a defined population to determine their responses to vaccination.) To encourage reporting of any adverse event suspected of being vaccine-induced, the criteria for reporting to VAERS are non-restrictive. In effect, the system accepts and includes any report submitted, no matter how tenuous the possible connection with vaccination might seem.
Generally, VAERS does not establish causality but is essential to the discovery of potential rare adverse consequences of medical products that may not become evident until many thousands or millions of people have been exposed to them.
FDA receives adverse event reports on the anthrax vaccine through a system similar to other adverse event reporting systems within the Agency. They are filed directly by health professionals as well as by patients or families. Reporting of adverse events associated with the use of anthrax vaccine is voluntary for individual healthcare providers but, as stated above, the vaccine manufacturer must report to FDA all reports of adverse events of which they are aware. It should be emphasized that adverse event reports can be made by a healthcare professional, a patient or anyone. If a patient's physician does not file a VAERS report, the patient can do so. FDA protects the confidentiality of patients reporting adverse events. FDA encourages individuals to report to VAERS any clinically significant adverse event occurring after the administration of any vaccine licensed in the U.S. Reports to VAERS may be made in writing or by calling a toll-free number, 1-800-822-7967. Reporting instructions are available on the FDA website.
CBER handles numerous inquiries from individuals concerning the anthrax vaccine. Individuals who believe they have experienced an adverse reaction are encouraged to report and provide information on filing a VAERS report. Forms are mailed and faxed to individuals upon request and individuals also are referred to FDA's website.
Since the beginning of VAERS operations in 1990, through September 15, 2000, 1561 reports of adverse events associated with use of the anthrax vaccine have been reported to VAERS. FDA understands, based upon information from BioPort, that from 1990 to present, approximately 2,000,000 doses of the vaccine have been distributed.
Of those reports, 76 are considered serious events, which are events considered either fatal, life threatening, or resulting in hospitalization or permanent disability. These reports are for diverse conditions, such as hospitalization for severe injection-site reaction, Guillain-Barr' syndrome, widespread allergic reaction, aseptic meningitis and multi-focal inflammatory demyelinating disease. There are no clear patterns emerging at this time. The remaining reports describe a variety of symptoms, including injection site hypersensitivity, injection site edema (swelling with fluid in tissue), injection site pain, headache, joint pain and pruritus (itching).
None of these events, except for the injection site reactions, can be attributed to the vaccine with a high level of confidence, nor can contribution of the vaccine to the event reported be entirely ruled out. With the exception of injection site reactions, all of the adverse events noted above occur in the absence of immunization.
While the data gathered from the VAERS system can serve as a useful tool in identifying potential problems, the reports on anthrax vaccine received thus far do not raise any specific concerns about the safety of the vaccine. With all vaccines, as the number of people that receive the vaccine increases, so will the number of adverse events reported to FDA. Thus, our knowledge of the vaccine will grow accordingly. FDA continues to view the anthrax vaccine as safe and effective for individuals at high risk of exposure to anthrax, when used in accordance with the approved labeling.
THE ANTHRAX VACCINE IMMUNIZATION PROGRAM OF DoD
FDA did not have an official role in the development or operation of the DoD's Anthrax Vaccine Immunization Program (AVIP), including the AVIP tracking system or the program's adverse event reporting system. In March 1997, DoD briefed FDA about their draft plan for the possible use of the anthrax vaccine to inoculate U.S. military personnel according to the FDA-approved labeling for six doses administered on a specified schedule over 18 months. Subsequently, FDA learned that DoD had formally adopted this plan.
In July 1998, DoD requested that the Department of Health and Human Services (DHHS) organize and coordinate a program to evaluate VAERS reports for the anthrax vaccine. In response to the request by DoD, a group of non-government medical experts was convened by DHHS in the fall of 1998 as the Anthrax Vaccine Expert Committee (AVEC). AVEC has met approximately every three to six weeks since fall of 1998. These experts have been reviewing all VAERS reports for the anthrax vaccine. Representatives of National Vaccine Injury Compensation Program (VICP), FDA, CDC and DoD have attended meetings, and FDA has provided information to assist the committee in its deliberations. AVEC is unique in that it provides an independent civilian expert assessment of adverse events reported for the anthrax vaccine.
We appreciate the Committee's interest in the Anthrax Vaccine, Adsorbed and BioPort. FDA will continue to work with BioPort, as we would with any manufacturer, in an appropriate manner to resolve all situations involving pending submissions and inspectional issues. By manufacturing products in a facility that is operating in a full state of GMP compliance, FDA can help assure that any product that is released by the company is safe and effective. Additionally, we will continue to monitor adverse event reports that are submitted through VAERS. FDA continues to believe that the vaccine is safe and effective protection for those individuals at high risk for exposure to Bacillus anthracis when used in accordance with the label.
1Philip S. Brachman, M.D., Herman Gold, M.D., Stanley A. Plotkin, M.D., F. Robert Fekety, M.D., Milton Werrin, D.V.M., F.A.P.H.A., and Norman Ingraham, M.D., F.A.P.H.A., Field Evaluation of a Human Anthrax Vaccine, AJPH Vol. 52, 632-645, 1962.
FDA/Office of Legislation
Web page created by frw 2000-OCT-03


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Photo Comments (2)Age: 22 Years Sex: Male Weight: 19 lbs.
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Yesterday was a big day for me. It was the death of my cat. I have had him for about five years give or take a moment. And it was time for him to go. I find it funny how I can cry for Charley more then I can cry for people. Because for me he was a person. He got grouchy like and old man and cuddley like a child. His expressions were so sophisticated it was fun. Towards the end it was sad. He "cried" more then he "sang" and it was just a hard time. I can say towards the end not a real complaint was heard. I loved him and I hope he is resting in peace.
Ugh, it is hard to be parted from anyone for long, but the hardest part is allowing my mother to leave me and travel to germany for the summer with her brother and other family. I don't care for her brother,but I want them back now. Whenever she is talking on the phone with her parents I can hear her and I keep trying to say hello, but she doesn't say hello back... =( She tells them she will be home soon and that she hopes I will remember her... but I wonder if she will remember her baby boy? I can't wait to sing for her and have her pet me and feed me when she gets back!
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The Aeolian Master - Book One - Revival HTML version
do anything necessary to save him, even if it meant putting his life on the line.
They ran up the stairs to the entrance of the crossover tube. The guard punched in the code and as the door
started to slide back they squeezed through the opening and started running down the walkway.
When they got to the other end, the guard punched in the code and the door slid back. They stepped out of
the tube and onto the prison-wall walkway. The phasors were firing random shots and melting whatever they
hit including the ground. The prisoners were below the rim on the embankment of the pit holding on for life.
The guards on the wall were running for their lives as Roqford sauntered along behind them. The guards
weren't stupid enough to try to fire on Roqford. It was known that these cats from a distance of thirty feet and
sometimes further depending on their size were so fast and so maneuverable that they could have you in their
jaws before you could pull the trigger. And if you did pull the trigger it wasn't likely that you would hit
anything but air.
To the left, about ten feet away, the warden was lying on the walkway with his head partly turned to the left.
There was a large pool of blood forming under his neck and chest, and running over the side.
The first thing Jacob thought as he looked at the warden was, unemployed. He wasn't sure, but he didn't
think he had enough money to get back to his home planet.
What have you done? he asked Roqford. And then he added, You've gotten yourself into a terrible mess.
Don't worry, answered Roqford. In actuality, I have saved the warden from a long and horrible death in the
Zi Pitsss. He stopped, turned, and laid down with his head hanging over the edge, facing the prisoners.
Jacob and the guard watched the firing phasors. Jacob wondered what started the whole affair and then
wondered why Roqford was so confident. And what did he mean he had saved the warden from a long and
horrible death?
And then the tower disappeared.
The top of it, along with the men inside, was gone instantly and then the rest of it, like a sandcastle beneath a
wave, crumbled into nothingness. And the phasors blinked out.
"By the curse of the Zorg," whispered Jacob. He didn't normally talk with this kind of language—being a
dignified manservant, but at the moment he was in the middle of a battle with phasor bolts flying everywhere.
His master was dead. He had been unable to save him, and more than that a friend of his was the culprit who
killed him.
"What now?" asked the guard.
"Yeah," answered Jacob. "What now?" He didn't know what to do. At the moment he was without a
So, the two of them just stood and watched.
Frostadeem, a tall, but lithe and agile man, was watching out the window as the sonic bomb disintegrated the
control tower. He was alarmed when the phasors first started firing at the prisoners and shocked when the cat
ripped out the warden's throat, but when the tower fell into a little pile of fine powder, he knew that the time he
had dreaded and hoped would never come had now arrived. He could not stop the movement of fate, and now
he would have to take action—dangerous action.
As his hand slipped to the butt of his phasor his finger inched its way up to the safety catch and flipped it off.
Frosty, as his friends called him, was not afraid, for he knew about danger and had known about danger his
entire life. By the time he was eight years old he was being trained by his father to be an asteroid miner.
When he was older his mother told him that people would gasp in horror when they heard that an eight-year-
old boy was being taken to the asteroid fields. But that was his father's way. "Teach 'em young and let them
become learned in the ways of life and in the ways of their profession, then they'll be successful, like me."
In terms of asteroid miners his father had been very successful. Most miners were able to eke out a living,
but would seldom hit the big one. His father, on the other hand, hit it big, not once, but twice and had enough
money put away to keep his family comfortable for three generations. So why did he keep mining? Because, as
he put it, "I love my work."
But Frosty knew that what he really loved was the danger. The asteroid belt, which is not common to most
solar systems, orbited between the fourth and fifth planet and contained hundreds of millions of asteroids. It


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LIVE: Yahoo CEO Carol Bartz SpeaksRob Hof
At the Morgan Stanley technology conference, analyst Mary Meeker is interviewing Yahoo CEO Carol Bartz. I'm listening on the Web, since media wasn't invited to the conference. I think it's Bartz's first major public appearance. And outgoing CFO Blake Jorgensen is here too; obviously, he hasn't checked out yet.
The upshot by the end: Not a lot of news, but it's clear Bartz has jumped deep into operations, and many changes are afoot. Some operations sound like their days are numbered. But she remained coy on whether she'd sell search to Microsoft. Even if she does, she'd want to keep access to the search data.
Here's the blow-by-blow:
Meeker: What has surprised you on the upside and on the downside? Bartz: Every week, I'm pleasantly surprised. I want the users to wake up in the morning, log onto Yahoo, check out what's important, and do the same at night, and as many times in between as possible. We owe them an easy, fun, non-frustrating experience. And no abandoned products floating like debris in space.
Advertisers want ease of use, they want our ad networks to work. Employees--we're ahead of the curve at Yahoo. We're on the way up, while others are on their way down. They want to work for a winning organization.
Stockholders want the stock up. So do I.
This is a whole new space for me. Internet advertising has gotten kind of same-old, same-old the last couple of years. Advertisers want better targeting. Nobody has the answer. They're asking us (what to do).
Meeker: Prospects for ad market--are they coming to Yahoo hoping online will save them, or are they pulling back? Bartz: Certainly the ad market is under pressure. They're looking for more bang for the buck. TV gets way too much of the spend. Print just gets worse. There's a rush to value. Damn straight it's a tough market.
Jorgensen: Yahoo saw Class 1 ad prices (premium, branded ads and sponsorship programs on major Yahoo sites) stabilize so far in the first quarter. (Problem is, at a pretty low level.)
Bartz: I think Class 1 will come roaring back. People want the big experience. They're not abandoning that.
What they (chief marketing officers) have told me is, "We'll experiment with anything. We've gotta see what works now."
Meeker: What's the response to the recent management reorg? Tone of morale on scale of 1 to 10? Bartz: The hope is a 10. The skepticism naturally is there because Yahoo--what a name... What was most broken was how people made decisions and getting product and editorial moving fast. Too many "two-in-a-box" management setups.
Jorgensen: Morale is clearly better than it has been. Over the last four or five years, there's been a lack of clear decisionmaking. People welcome that. Even if the decisions are not in their favor.
Meeker: What's core now for Yahoo? Bartz: Front Door, sports, news. And the brilliant sales force. Everything's up for evaluation. (She has a "wall of shame" of products that aren't up to snuff or were essentially abandoned.)
Let's make sure we have a very fine-tuned operation. Figure out where we should do M&A.
Meeker: No draconian moves necessary? Bartz: I'm not afraid of it for a second. But ... smart isn't just cutting expenses or prices. It's cutting bad expenses.
Jorgensen: Looking at whether the user experience is the best it can be. Is there a way to improve the user experience by removing ads?
Bartz: For instance, cutting ads on Yahoo Mail on low-bandwidth connections in international markets.
Meeker: Any new inventory to be found? Bartz: I hope so.
Meeker: Why is Yahoo gaining market share in search? (Barely, it must be said.) Bartz: They're staying with. We have absolutely stabilized search. We have been investing. The technologists are good. And we'll continue that.
Meeker: What's the latest thinking on the calls for Yahoo to get out of search (via a deal with Microsoft)? Bartz: Search data is extremely important. I said this to Mr. Ballmer: I'm not going to negotiate with my 50,000 favorite friends. We are going to negotiate as companies negotiate, and that is privately.
Meeker: Why aren't Yahoo ads more effectively targeted? Bartz: On behavioral targeting: Being able to watch what a user does as he roams around the site ... say a mom with a baby--let's serve up relevancy to her. We're going to get better and better at that.
It's a long slog. But I like the long slog. If it was an easy path, we'd have to dream up something else. We want to be able to follow them around and have some ideas. Who wants the blue link (search)? That's not fun anymore.
Questions from audience now: Q: Something about U.S. vs. international Bartz: Europe has been managed too many times by too many people. Frankly, a lot of the European properties and content were some of the abandoned ones. Plans M&A, some partnerships, but mostly getting best-of-breed people on the ground.
Jorgensen: Many mobile partners--trying to establish the user platform and integrating into core product (on Web/PC).
Q: Similarities in management organization between Autodesk and Yahoo? Bartz: There's many ways you can go. Management reorgs fix yesterday's problems and create tomorrow's problems. Yahoo had gotten fairly convoluted. Organizations were built around people, not the best organization. There's a lot of my experience I can draw on, definitely.
Another Meeker question: Can outside services, especially social media, be integrated into my Yahoo experience? Bartz: That certainly would be high on my "wouldn't it be wonderful" list. Social media very important. I'm not a big NIH--I don't believe we can (do) the next Facebook.
Jorgensen: Testing new version of home page, opening up to other providers. You'll see much more interaction with outside partners.
Bartz: Our (current) home page is very old-fashioned.
Meeker: Will Yahoo's newspaper consortium be material in the next few years? Bartz: Doesn't answer directly. Met with three leaders of the consortium. 30,000 sales people in these newspapers. They are turning to selling online like gangbusters.
Q: What have you learned in the first 35 days about linking search and display ads? Bartz: While optimization is good, they are linked in the minds of the top 200 advertisers. We have to have the information that search tells us the customers intended--regardless of whether we manage it or someone else manages it.
Meeker: It sounds like you're saying Yahoo has gone from a weak position to a strong one in search (vs. Microsoft, though not mentioned by name). Bartz: Yes, ma'am.
Q: Guy with a young company (who says he once worked with Bartz at Autodesk) says consolidating ad spending on Google AdSense and Yahoo, just those two properties. Bartz: Sounds happy with this comment, no surprise.
Q: What about Yahoo Mail and Yahoo Maps? Bartz: Mail is really important to us. That's a core property for us. Maps? I don't use Yahoo Maps. I use Google Maps, I'm just telling you.
Jorgensen: Part of the challenge on Maps is ... we chose to partner a long time ago. I don't see that we would jump in to go much deeper on the map side.
And that's it.


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Washington state must reform its overly generous pension system. The Seattle Times editorial board favors pension reform of the type proposed by state Sen. Joseph Zarelli.
IN the work to balance the state budget, short-term gains are nice, but the long term is critical. One of the most fruitful areas for saving money long term is public-employee pensions. This cannot mean taking away a benefit already promised, which is illegal. Surely it will mean changing what is promised to new employees.
An example is Senate Bill 6378, sponsored by Sen. Joseph Zarelli, R-Ridgefield. Under the bill, new state employees would no longer get a full pension at 62 after 30 years service or an 80 percent pension at age 55 — a benefit light-years away from what most private-sector workers have…
LINK – seattletimes.nwsource.com


text:
Discussion in 'Fan Zone' started by WoodysGirl, Feb 12, 2013.
Water is wet
I'm catching it on the ticket1310 on I♥radio.
I'm on delay, but fully 20 minutes into this filibuster he still hasn't taken a question.
So far, a whole lot of nothing to report, basically introducing the coaches. Went over the offense and avoided a lot except he stated how good the offense was over the years, stats and such.
Made good points about the defense in relation to take-a-ways. He is doing his best to avoid the play-calling topic though.
Calvin Watkins @calvinwatkins
Jason Garrett jokes he leads the league in scout team reps as a QB
Garrett said his respect level for Monte Kiffin is "off the charts".
The playcaller might not be named until August.
Garrett said it wouldn't be hard to give up the playcalling duties.
Garrett won't get into the specifics of the mechanics of what needs to be done to make the change
Clarence Hill @clarencehilljr
Garrett said monte kiffin is as good a defensive coordinator as this league has seen in a long, long time.
Garrett said likes kiffin's "demand for detail at getting it right. My respect for him is off the chart. We are fortunate to have him as DC
Nick Eatman @nickeatman
Jason Garrett explaining his own ties to Tampa bay coaches back in 2004. He's more familiar with kiffin, marinelli than most people realize
Tim MacMahon @espn_macmahon
Jason Garrett has talked for 10 minutes without taking a question or saying anything newsworthy. Lots of talk about '04 Tampa training camp.
Garrett on play-caller decision: "We'll probably play preseason game in early August and hopefully we'll have it all worked out by then."
Carlos A. Mendez @calexmendez
Garrett told a Kiffin story. Now he has a Marinelli story.
First question: did you initiate these changes? Starts to talk about collective decisions.
Garrett says he and Callahan are trying to figure out new direction. Says Cowboys have had a system with a 'primary play-caller.'
Asked when play-caller will be decided, Garrett punts it a long way. Says by the first preseason game in Augusta.
Define 'breakthrough' season. Garrett: To get to the point where they were last season and win that last game and make playoffs.
Garrett says he wants 'shared values' with his assistant coaches. And if they have a personal connection, that's a plus.
Rowan Kavner @KavnerDC
Garrett talking about his experience w/ Kiffin as a backup qb in Tampa. Built a relationship with Kiffin then and knew he wanted to coach
Jon Machota @**********
Did Jason Garrett initiate the changes? Garrett said he, Jerry Jones, Stephen Jones and entire staff made collective decisions.
Garrett on who will be calling plays: There's a lot of time between now and first preseason game. "Hope to have it all worked out by then."
Maybe Jason Garrett's most common response since becoming Cowboys head coach: "I don't want to get into the details on all of that."
Will it ultimately be Jason Garrett's decision on who calls the plays? Garrett: "Yes."
Jason Garrett "very disappointed" in Jay Ratliff's arrest. "We'll just have to let that situation play out."
Jason Garrett says he prefers using the word "urgent" not "uncomfortable" when describing the mood at Valley Ranch.
105.3 The FAN @1053thefan
Garrett not answering if he or Callahan will call plays: "I don't want to definitively say that one way or another." http://bit.ly/SJRWjZ
Charean Williams @NFLCharean
Garrett said he and Callahan "will work through mechanics" about play calling. No final decision has been made.
Mike Garafolo @MikeGarafolo
After all that, Garrett doesn't give a full answer on play calling. Said they're "trying to move in that direction" of having Callahan do it
Albert Breer @AlbertBreer
Jason Garrett invoked Schembechler -- "The Team, The Team, The Team" -- when the play-calling question came up again. Says no decision yet.
Garrett ran through a list of teams -- New Orleans, Green Bay -- that have won with head coaches as play-callers.
Jason Garrett mentions that they don't need a decision on play-calling until preseason games begin. But seems resigned on this one.
Jason Garrett on whether or not Jerry wants him calling plays -- "You'll have to ask him that". Says Jerry always like play-calling HCs.
Brandon George @dmn_george
#Cowboys coach Jason Garrett still won't say definitively that OC Bill Callahan will call the offensive plays. Says still working through it
Garrett says final decision might not be made on who the "primary" play-caller will be on offense until early in the preseason.
Jason Garrett says that ultimately it will be his decision who calls the offensive plays for the #Cowboys next season.
#Cowboys coach Jason Garrett says that the switch from a 3-4 to 4-3 defense will put them in a position to "absorb" injuries better.
Jean-Jacques Taylor @JJT_ESPNDallas
Red J just lumped the Cowboys with the best offenses in NFL. "We have played good offensive football," he said. Hmmmm.
Derek Eagleton @derekeagleton
Garrett mentions takeaways under Marinelli. In 3 years as DC in CHI: 44, 31 & 35 takeaways. Most DAL had in 10 yrs is 31. Averaged 24/season
Jon Machota @**********
Jason Garrett on Bill Callahan: "Bill wouldn't be on this staff if we didn't have shared values."
Jason Garrett on deciding who will call plays: "We trust the process. We're confident we'll get it right."
Would Cowboys be switching to 4-3 if they had won in Washington? JG: "Don't know. We'd have to see how the rest of the season played out."
Rowan Kavner @KavnerDC
Garrett also says media makes too much of who will be named playcaller since all coaches are involved in gameplanning
At one point I wasn't sure Garrett would take questions. He did so, but I'm still left wondering what substantial answers were there
Albert Breer @AlbertBreer
Summary of Garrett presser: No decision on play-caller, yet. System on O will have Callahan influence. Kiffin/TB coaches won JG over in '04.
Tim MacMahon @espn_macmahon
We might have to wait almost 6 more months for answer to a really simple question: Who's calling plays for the Cowboys? Unless Jerry slips.
Play-calling duties could be determined by preseason opener coin flip. Heads, it's Garrett. Tails, it's Callahan.
Brandon George @dmn_george
#Cowboys coach Jason Garrett: "Bill [Callahan] wouldn't be on the staff if we didn't have shared values."
Only the #Cowboys can hold an hour press conference and leave everyone walking away with more questions than answers.
I may not think Garrett is a very good coach overall, but I love how he never lets press conferences get out of hand. A lot of the questions he gets asked would send pressers into a bad place with a lot of other coaches.
Good lord
Shaun sharif, Clarence hill and Calvin Watkins are stupid.
Who invited Shaun sharif? What a joke.
Hopefully his comment on Ratliff means he's gone! Get him outta there
What did he say?
This is depressing. They obviously are not going to install a new offense, if they are wating for August.
Hello to the lowest scoring first half team in the NFL, AGAIN
Nothing really. He got a stern look on his face and said "we will let it play out" or something like that.
He said he was "very disappointed."
Yep. Listening to him, you'd think we really were right there with the Saints and Texans and Packers, just as he said.
In fact, if our offense was as excellent as he's saying, why change anything?
What ur seeing is not a future head coach but a future Political figure. Reminds me of many politicians who never gives u a direct answer but skirts around the question. Sometimes they go as far as telling falsehoods in order not to give the correct answer. Future Politician.
After listening to todays PC, I feel strongly that JG will remain, no matter what JG states, the Playcaller and our season will be much the same as the last two years--SAD!!
Just let Tony call all the plays. He changes almost everyone that is sent in anyway.
I bet he doesn't want to change anything. Jerry is who is forcing any change. Now, with all the backlash against Jerry and his "forcing" Garrett to give up playcalling, I'm afraid to prove the point Red is still in charge, Red might very well remain the playcaller next season.
Honestly at this point it really doesn't matter to me who calls the plays. If the Cowboys have another yr like the last 2 jg is gone regarless who is calling the plays. I've never really had a problem with the play calling. I just have a problem with his playbook.
Lord have mercy!
Maybe so, Stretch Smith is saying he thinks Jason will still call plays when it's all said and done...
And kirk -- dead on about the politician part. That's one reason I don't care for him, to put it politely.


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Medications and the Risk of Sudden Cardiac Death
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Cardiovascular Diseases
Heart Diseases
Death, Sudden, Cardiac
Ventricular Fibrillation
|Study Type:
|Study Design:
|Time Perspective: Retrospective
|Study Start Date:
|September 2005
|Study Completion Date:
|May 2010
There are more than 400,000 sudden cardiac deaths annually in the U.S, of which 85% or more are caused by ventricular tachyarrhythmias. Medications are an important modifiable risk factor because many have effects that can provoke lethal arrhythmias. There is increasing suspicion that several drugs in four widely used classes of non-cardiovascular medications-fluoroquinolone and macrolide antibiotics, antipsychotics, and antidepressants- are pro-arrhythmic and thus increase the risk of sudden cardiac death. Published epidemiologic studies have quantified the risk conferred by older antipsychotics and antidepressants as well as oral erythromycin. The current project will extend these studies to newer medications that are used by an estimated 20% of adults in the U.S. Studies of surrogate markers suggest that the pro-arrhythmic effects of these drugs vary markedly.
This retrospective cohort study has three specific aims in testing the relationship between certain non-cardiovascular medications-fluoroquinolone and macrolide antibiotics, antipsychotics, and antidepressants- and sudden cardiac death.. Specific aim 1 tests the hypothesis that there is corresponding variation in risk of sudden cardiac death. In vivo data suggest that concurrent use of study drugs with other common medications that inhibit their metabolism could markedly increase drug concentrations, and thus risk of arrhythmias. Specific aim 2 tests the hypothesis that these pharmacokinetic interactions, defined a priori, increase risk of sudden cardiac death. The hypokalemia caused by the commonly used potassium-wasting diuretics may amplify the pro-arrhythmic effects of medications. Specific aim 3 tests the hypothesis that concurrent use of study drugs and these diuretics increases risk of sudden cardiac death. The investigators will conduct a retrospective cohort study in TennCare, Tennessee's expanded Medicaid program. Computerized TennCare files, linked with death certificates, provide the information necessary to define the cohort, classify followup according to medication exposure and potential confounders, and identify cases of sudden cardiac death using a validated computer case definition we have developed. The cohort will include an estimated 800,000 persons with 15,000 sudden cardiac deaths during 5,000,000 person years of followup and thus will have excellent power for risk estimates. The study will provide data that clinicians need to prescribe these widely used medications in a way that minimizes the risk of sudden cardiac death.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Please refer to this study by its ClinicalTrials.gov identifier: NCT00241800
|Wayne Ray
|Vanderbilt University Medical Center
|ClinicalTrials.gov Identifier:
|NCT00241800 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 17, 2005
|Last Updated:
|April 26, 2012
Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Death, Sudden
Death, Sudden, Cardiac
Ventricular Fibrillation
Pathologic Processes
Heart Arrest
Arrhythmias, Cardiac
ClinicalTrials.gov processed this record on May 25, 2017


text:
Press Release
April 23, 2012Cascade Microtech to Announce First Quarter Results on April 30, 2012
BEAVERTON, Ore.— April 23, 2012— Cascade Microtech, Inc. (NASDAQ:CSCD - News) will release financial results for its first quarter ended March 31, 2012 at approximately 4:00 p.m. EDT, on Monday, April 30, 2012. The company will host a conference call beginning at 5:00 p.m. EDT (2:00 p.m. PDT) that same afternoon to discuss these results.
A simultaneous audio cast of the conference call may be accessed online from the investor relations page at www.cascademicrotech.com. A replay will be available after 7:00 p.m. EDT at this same internet address. (For a telephone replay available after 7:00 p.m. EDT dial: 888-286-8010, international: 617-801-6888, Passcode: 29128983)
About Cascade Microtech, Inc.
Cascade Microtech, Inc. (NASDAQ: CSCD) is a worldwide leader in precision contact, electrical measurement and test of integrated circuits (ICs), optical devices and other small structures. For technology businesses and scientific institutions that need to evaluate small structures, Cascade Microtech delivers access to electrical data from wafers, ICs, IC packages, circuit boards and modules, MEMS, 3D TSV, LED devices and more. Cascade Microtech's leading-edge stations, probes, probe cards, advanced thermal subsystems and integrated systems deliver precision accuracy and superior performance both in the lab and during production manufacturing of high-speed and high-density semiconductor chips. For more information visit www.cascademicrotech.com.


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on sale!
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Posted by Amanada on 25th Aug 2014
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