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Re: st: nonlinear growth curve in xtmixed
"Stas Kolenikov" <email@example.com>
Re: st: nonlinear growth curve in xtmixed
Fri, 12 Dec 2008 14:54:21 -0600
As of version 10, Stata provides -xtmelogit- and -xtmepoisson- for
logistic and Poisson models, respectively. I believe Singer & Willett
only talk about logistic models there, right? You can say those are
nonlinear models since the mean functions are nonlinear in x's; to me
those are extensions of generalized linear model, and hence there is
at least some linear flavor to them. PROC NLMIXED can fit some crazy
models with direct integration of the random effects (as far as I
know), and full functionality of that is not available in Stata (at
least in the easily available commands; you can write anything you
want in Mata!)
On 12/12/08, josemaria <firstname.lastname@example.com> wrote:
> Dear Statalisters:
> Judith D. Singer and John B. Willet, in their book "Applied Longitudinal
> Analysis", Oxford University Press, 2003, present, in pages 225-232,
> analysis for nonlinear growth curve using the PROC NLMIXED of SAS, and
> explain that, at the time of writing the book, Stata did not have yet the
> same capability.
> This is also informed at the end of the page: "Stata Textbook Examples
> Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence
> by Judith D. Singer and John B. Willett
> Chapter 6: Modeling Discontinuous and Nonlinear Change",
> site
> http://www.ats.ucla.edu/stat/stata/examples/alda/chapter6 :
> "Table 6.6 on page 231.
> * Skipped these for now. Stata does not yet do nonlinear mixed models." Is
> it possible now to do such analysis in Stata?
> Than you for any orientation.
> José Maria
> Jose Maria Pacheco de Souza, Professor Titular (aposentado)
> Departamento de Epidemiologia/Faculdade de Saude Publica, USP
> Av. Dr. Arnaldo, 715
> 01246-904 - S. Paulo/SP - Brasil
> fones (11)3061-7747; (11)3768-8612
> fax (11)3714-2403
> www.fsp.usp.br/~jmpsouza
> *
> * For searches and help try:
> * http://www.stata.com/help.cgi?search
> * http://www.stata.com/support/statalist/faq
> * http://www.ats.ucla.edu/stat/stata/
Stas Kolenikov, also found at http://stas.kolenikov.name
Small print: I use this email account for mailing lists only.
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Alice, 107 yo Holocaust Survivor's BD
Shalom, one and all. Special request: Please help make a very wonderful Birthday Greeting avalanche to Alice, who Jerusalem Connection has an article about, today.
Watch Video of Alice's story: http://www.thejerusalemconnection.us/blo...
Alice is going to be 107 years old, on the 26th, and the oldest Holocaust survivor alive, etc, and so on. So, Please?
Send BD email to: firstname.lastname@example.com Pass the word.
The Poem, I am sending to her (first part, tonge in cheek, humor intended):
Alice Herz-Sommer 107 BD
By Arley Steinhour 112010
On this Twenty of November, two thousand years, plus a ten,
Woke up this very Sabbath, praising God, with love, and grin.
After prayer, and chat with Him, I rustled up breakfast that be mine,
Eggs, potatoes, apple sauce, covered with white onion, chopped fine.
Sat down at my computer, for a day of witness, eating my confection,
Munching on my breakfast, saw an a message from, 'Jerusalem Connection.'
Presented was a story about a girl I know I'd love, but I need to state;
At seventy two, I'm feeling old, but at her age, I think I be too Late.
This shining, lovely, person, plays piano, oh so well,
Her lips would never tell a villain, he should go to Hell.
She's kind of thin, but I don't mind, my waist has some excess girth,
What love this tiny woman shines, from eyes, and heart, from birth .
I did believe she'd do just fine, to fill my lovelorn plate,
But on the twenty-sixth, she's beyond, what I dare ask her wait.
If only I were one year older, or she be one year less,
I could have a chance of being, not too young for her to bless.
Oh, sorry, didn't I tell you, Alice Herz-Sommer, be her name,
One-Oh-Seven, makes me too young, to play in her life game, what a shame.
So, I guess I'll just have to worship her, from a distance, never meeting,
But maybe, when I get to Heaven, she will bless me with a word of greeting.
Just think, not even Holocaust, could rip away her life of Love,
Alice Herz-Sommer I'd offer, is truly blessed by God above.
I do not know her full story, only bits of her experience to date,
But we will have eternity, to learn, should she wish, to us relate.
So, HAPPY BIRTHDAY, Alice, may you have a grand, grand party,
May those who come, to celebrate your day, share with you my Hale and Hearty:
Respect, and God Blessed Love, for YOU.
Arley Steinhour, a Christian Brother. AMEN
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- If you already have an account, follow this link to login
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subset: commoncrawl


text:
He has proven to be one of the most divisive figures in politics, but Nigel Farage has risked alienating half the population with his latest outspoken comments.
In a series of controversial remarks, the Ukip leader has claimed that working mothers are "worth less" than men to employers in the City.
Mr Farage, who worked in the City for 20 years at a brokerage firm, said women who take time off to take care of their children become less "valuable" to employers, and therefore get paid less than men, because they are not as committed to their clients.
Speaking at an event in the City, he said: "In many, many cases, women make different choices in life to the ones that men make simply for biological reasons.
"If a woman has a client base and has a child and takes two or three years off work, she is worth far less to the employers when she comes back than when she goes away because her client cannot be stuck rigidly to her."
Mr Farage insisted that there is "no discrimination" against women as long as they are willing to sacrifice their family life and remain childless to get ahead.
He added: "I don't believe that in the big banks and brokerage houses and Lloyds of London and everyone else in the City, I do not believe there is any discrimination against women at all.
"I think that young, able women who are prepared to sacrifice the family life and stick with their careers do as well, if not better, than men."
Mr Farage went on to reject the idea that men should stay at home to facilitate a woman's career ambitions.
"I have to admit I was never going to be one of them myself," he added.
- More about:
- Banking
- Biology
- Career Path
- Family And Parenting
- Lloyds TSB


text:
Hey everyone. Just started Simplefit yesterday. I am 29 years old, almost 30. I am 5'10" and weigh 190 lbs. I have gained a lot of weight in the last 2 years . I hope this program will give me strength, endurance and change my current physique.
Day 1, Level 1 - 18 rounds
I was somewhat disappointed with my results, but I was really sweating at the end of the workout, so it must have been good!
I was able to do pullups during the the first 10 rounds, but couldn't do anymore. However, there is a machine at the gym that assists with the pullups. I put it on the lowest setting (50 lbs) and was able to do the last 8 rounds. Is this OK or do I need to stop once I am unable to continue with regular pullups?
Also, I was really being deliberate and paid close attention to my form during each round. Should I be less concerned with that and just try to do as many rounds as quickly as possible?


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|MK3 Focus The place to chat about general questions, window tinting, exterior body, interior and lighting upgrades for the third generation 2012-Current Focus.
|Topic Review (Newest First)
EDIT: What I'm reading says that Ti-VCT eliminates the need for an EGR because exhaust gas temperature control can be done in timing. Sources: [1] [2] [3]
RockAuto and FordParts.com tell me otherwise...
EDIT: Although, ShopKey doesn't tell me anything about its existence or whereabouts.
One point is EGR.. The little devil EGR usually ruins engine braking.
Most manual transmission cars in my recent past have needed to block the EGR valve in order to get ANY engine braking..
I wonder if the Mk3 setup is shutting the EGR so there really IS some engine braking.
In my manual 2012 if I am using cruise control on a long downhill (Here we have a long hill going up to the local water divide on I94 from Milw to Waukesha) with cruise on.. the car does maintain the speed limit.
In neutral on the same downhill the car gains over ten mph.
|I agree with Roman5.8 on his description of the DCT. Yes it will downshift while going downhill and living in a mountainous area, Vancouver Island, I like it. Going down mountain passes I deselect cc and go to S and manually control the gear selection. While following other vehicles down the passes with most on them hard on the brakes coming to curves I drop one or two gears and normally don't have to touch the brakes. Yes the engine revs up, but this engine is redlined over 6000 rpm. My previous vehicle an Escape will a TC type auto would also downshift going downhill on a long grade with cc on. It would do much faster if the downhill control button was depressed. Some of us are much more automatic dependant as we have aged and our knees are shot. Just loved that six speed manual tranny in my old HD 5.9 diesel pickup, but it could not engine brake going downhill without the exhaust engine break activated. Happy Cruising.
|Personally I never run CC while in Sport mode, that is reserved for spirited driving, especially on the twisties. Cruise is reserved for highway with the car set to Drive.
That was mostly just jest. I prefer a manual, but that's just because I prefer it! Some prefer an automatic.
For the sake of argument though; most of those cars are not automatics; they are automated manuals. Pedantic I know, but, there's an important difference and that's in the clutch. The 'slushbox' term, as you probably know, comes from the torque converter. And I know you know how they work (judging by your knowledgeable posts elsewhere) but for the benefit of others reading, basically (put very simply), it's pumping fluid across two turbines. One attached to the engine, the other to the transmission. The end result is reduced power transfer to the transmission, 'softer' shifting and performance, and other disadvantages. Those 'slushbox' automatics are still popular among drag racers in 2 and 3 speed variations because at WOT some of the disadvantages are minimized and the lack of a need to shift is handy. (Though top fuel dragsters only have one gear, and use a series of clutches!). Torque converters also have a huge disadvantage in engine braking. The transmission needs to be in a low lower 'gear' in order for engine braking to take effect. That's why you can take your foot off the gas and coast with an automatic (though an automated manual may mimick that by releasing the clutch during coasting). That was the intent of what I was saying, most true automatics do not do any real engine braking with cruise control because they are at a disadvantage there. An automated manual though, might.
A clutch connects nearly all of the power to the engine. Take advancements in clutch technology, computer technology, and transmissions, and you can take a standard manual transmission and connect it with a computer controlled clutch for fantastic performance. (There's a 'hybrid' variation of this in a lot of big rigs, where the driver selects the appropriate gear to start with and the clutch pedal is used when stopped and to take off from a stop, but is no longer needed once moving; the computer takes over shifting and the clutch functions).
No doubt that dual-clutch 'automated manuals' are the pinnacle of performance when done right. Though they are very different. This thread is further evidence of that. People not expecting it to behave like it does; because it behaves a lot more like a manual, because it is! The Ford DCT, for example, is a 6 speed manual transmission. It is! The difference is between the transmission and the engine; what makes it an 'automatic' is the automated dual-clutch system. (Okay, there are some internal changes if you get really technical, but the idea is the same).
As for MY preference, I won't notice 1mpg difference, and sometimes performance arguments get silly. Half a second on 0-60? A couple mph in top speed? Ultimately, those things are useless. Kind of like guys arguing who has the highest top speed. Aside from an oval NASCAR track, even a race car on a track rarely sees it's top speed. In fact, much of the track is done below 100mph!
For me, it comes down to fun to drive. I don't care if a car can do 160, 180, or 200. That's not where the fun is. The fun is in the handling and the 0-60 acceleration. The fun is also being in control of the car and having the fun of a manual transmission (which isn't for everyone, some prefer an automatic). After all, it's a focus. There are much faster cars for similar, or a little bit more money. Or, heck, you can get a used low mileage Mustang GT for under $20k. But no reason not to have something that is fun to drive, and reliable! The manual transmission makes that more of a reality, IMO. Plus, automated manuals and slushbox automatics alike are generally less reliable than a manual. A manual transmission has less parts and the parts are simple!
Kudos to Ford though. I think the DCT is awesome. I do think Ford should educate the customers though. Like, calling it an automated manual in the book instead of an automatic. Elsewhere they call it that, but I think they do a disservice telling customers they have an automatic transmission; because they really don't, and they should be educated in how it will behave differently than the automatics they are used to. They could also be educated on how to get the most out of it!
I test drove one with a DCT (nothing with a manual in stock). It was a great transmission! But I still prefer a manual.
I used to think automatic transmission = slushbox.
These days there are a number of cars with an optional automatic outperforming a manual.
Also keep in mind that a GT-R (one example of many) is only available with an automatic.
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Answers Home
» Adoption & Rescue
I want to get a dog, but have been putting it off as I would be out of the house 9-7 Mon- Fri. Any Suggestions?
I live in the west of Ireland, perfect for long walks and jogging. I am an active guy and would like to get a dog to come alone for those walks etc and also for companionship. Due to the hours I work, I don't know if it would be fair to get a dog and not give it the attention it needs during the week? (Leaving it alone for most of the day) Is there a particular breed that would be suitable for my situation or is it just not suitable?
Asked by
Member 1105606
on Apr 13th 2012
in Adoption & Rescue
- Cast your vote for which answer you think is best!
It would be ok if you hired a dog walker or put him in doggie daycare.
Jax (earned her wings 5/30/12) answered on 4/13/12. Helpful? / 0
I would agree with using a dog walker or day care especially if you go with a high energy breed. Perhaps an older dog vs a puppy as they might fare better being home for longer periods of time. Try using of the breed finders online which will match breeds with lifestyles.
Callie (Calliope) answered on 4/13/12. Helpful? / 0
i wouldnt get a puppy since they wouldnt be potty trained. Your house would become a potty for the dog.
Carter answered on 4/13/12. Helpful? / 0


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A dirty house is often called a "pigsty," which is an insult to cows because they're also disgusting. Farm out your chores with this Groupon.
The Deal
- $1,499 for exterior painting for a whole home up to 1,700 square feet ($2,500 value)
1508 Bay Road
Miami Beach, FL 33139
+19545532401Get Directions


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Campanile Brive La Gaillarde Ouest
Select your stay dates to check availability
Campanile Brive La Gaillarde Ouest
About the hotel
Property Location
Located in Brive-la-Gaillarde, Campanile Brive La Gaillarde Ouest is connected to a shopping center and close to Eglise Saint-Robert and Collégiale St-Martin. This hotel is within close proximity of Maison Denoix and Les Jardins de Colette.
Make yourself at home in one of the 43 air-conditioned rooms featuring LCD televisions. Rooms have private balconies. Complimentary wireless Internet access keeps you connected, and digital programming is available for your entertainment. Private bathrooms with bathtubs feature complimentary toiletries and hair dryers.
Take in the views from a terrace and a garden and make use of amenities such as complimentary wireless Internet access.
Enjoy a satisfying meal at a restaurant serving guests of Campanile Brive La Gaillarde Ouest. Buffet breakfasts are available daily for a fee.
Business, Other Amenities
Featured amenities include express check-out, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite.
Hotel Facilities
- Television in common areas
- In-room accessibility
- Free WiFi
- Multilingual staff
- Express check-out
- Garden
- Free newspapers in lobby
- Terrace
- Free self parking
- Smoke-free property
- Number of buildings/towers - 2
- One meeting room
- 24-hour front desk
- Restaurant
- Total number of rooms - 43
- Number of floors - 1
- Accessible bathroom
- Breakfast available (surcharge)
- Year Built 1985
Room Facilities
- Connecting/adjoining rooms available
- Premium bedding
- Access via exterior corridors
- Iron/ironing board (on request)
- Digital TV service
- Coffee/tea maker
- Electric kettle
- Blackout drapes/curtains
- Free cribs/infant beds
- Desk
- Private bathroom
- Air conditioning
- Hair dryer (on request)
- Free toiletries
- Bathtub only
- Free WiFi
- Free newspaper
- Daily housekeeping
- Balcony
- Phone
Hotel Policy
National Rating
This property has received its official star rating from the French Tourism Development Agency, ATOUT France.
Know Before You Go
- One child 10 years old or younger stays free when occupying the parent or guardian's room, using existing bedding.
- The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Fee for buffet breakfast: EUR 9.90 for adults and EUR 4.95 for children (approximately)
- Pet fee: EUR 5 per pet, per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Mandatory Fees and Taxes
You'll be asked to pay the following charges at the property:
- A tax is imposed by the city: EUR 0.95 per person, per night
We have included all charges provided to us by the property. However, charges can vary, for example, based on length of stay or the room you book.Show all hotel policy Show less hotel policy


text:
It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is up to you but will greatly enhance your chances of your profile being viewed by interested members. Write a little something about yourself, your hobbies and upload some good photos of yourself.
Utilise our website's state-of-the-art search to discover over 60s members who meet your requirements. Or just leaf through listings and discover folks that seem interesting.
Located someone who tickles your fancy? Send them a word or two or just a wink and wait for their response. With a little luck you'll be on your way to locating the love of your life.
It's quick and easy


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Could somebody helpme ?… Any idea will be highly apreciated!!
Kind regards!
Post By:user_9387 | Reply
Hello friends,
I need to create a structure like this http://www.gfii.com/pc_product_detail.asp?key=91ABD7E01A8A4A689F2C7EE460C17396 . If you see there is a main product, and inside we got a table with many variations of the product like Thread Form, Decimal Eq (in), Decimal Eq (mm), Width / OD (in), etc.
And if you make click in one of the SKU's from the table you can open the variation in a detailed page. Can Magento handle a configurationn like this ?.. Is this possible with a configurable or grouped product?..
Is there a extension for this?
Kind regards!
Could somebody helpme ?… Any idea will be highly apreciated!!
Kind regards!
Well I saw the extension and it doesn't seems to be what I'm looking for. I think I can solve this with related products?.. Maybe showing them in a table?…
Could somebody helpme?
Kind regards!
Hi ricardoinvent,
Sorry we don't have demo yet but you can purchase and we will send you the instructions if it will not help you we have 14 days Money Back Guarantee policy.
So do Risk-free purchase.
Check this extension Import Configurable and Grouped Products
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Costume Information
|finally figured out how to make most of the costume, so I'm about to start as soon as I can afford the materials ;)
Oh my gosh yes!!!!!! >3<
I think I love you >w< I did Broadway Ariel last year. This will be amazingly awesome!!!!!! XDDD
YES!!!!!!!!!!!!!!!!!!!! I LOVE this version of Ursula!!
lol thanks girls....I hope I can find a way to make this, it's really complicated and time affording...we will see...;)
I love Ursula, the little mermaid is my fav ever and Ursula is just the most bad ass baddie. I hope you get to do this i really do i would love to see it.
Beautiful dress and incredible make-up!
Thank you! I love the dress too, but that will be the hardest part to get right, especially all the tentacles...
oh my word that would be a challenge, did you see the youtube video of the leg contraption she had under the costume?
the construction is crazy!!! ;)


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Contact us 24/7: +1 877 678 9627
View product details
Zoom In
- - Measurements can be found in the link above
Étoile Isabel Marant's sturdy leather belt is stitched with red and black embroidery. Channel the French designer's inimitable sense of style by wearing yours with a printed blouse and skinny jeans.
Shown here with: Étoile Isabel Marant top, Maria Rudman bracelet, Chan Luu bracelet and bracelet, T by Alexander Wang jeans, Isabel Marant shoes, Maison Martin Margiela clutch.
- - Black leather (Calf)
- - Red and black embroidery
- - Silver buckle fastening
Product Code: 407871
Shop more:
For alternative suggestions, contact our Fashion Consultants
Help & Advice
Product Code: 407871


text:
Man flu is a medical condition that causes men to proclaim they are gravely ill and possibly at death's door with the flu, when they in fact only have a cold. But new research has revealed an astounding fact - women are just as likely to exaggerate their symptoms and claim to have the flu as their male counterparts.
A poll by Panadol Cold and Flu showed almost half the people complaining of flu to their doctor had misdiagnosed themselves. Pharmacists said 61 per cent of their customers were guilty of the "crime". However, only 54 per cent of those claiming they were suffering from the flu were men.
Anecdotal evidence highlights men's ability to indulge in extreme theatrics when struggling with a sniffly nose and sore throat. Aucklander Billie Hawley said: "While I'm happy to take some cold and flu remedies and carry on, my husband just loves to curl up on the sofa so if anyone calls round they can see he's sick (the bedroom's far too private). He then proceeds to tell them he has pneumonia and that he is close to dying."
Another woman said her man "dies a very noisy death", and another wrote that her hubby "has a whisky, curls up and acts like a big baby".
And the difference between a cold and the flu? A cold is generally a nose and throat problem, while the flu is more severe with fever, headache, muscle aches, chestiness, and loss of appetite.


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This Blue and White Vase measures approx. 12" tall and 6" wide. The handles on the top half are of dragon heads. The front and back center area show a dragon under a phoenix. There is a patterned design around the top rim. The bottom has an oriental stamp in blue. Please feel free to contact me if you have any questions. Thank you for shopping with us at Something Wonderful.
4 other shoppers have this item in their Cart or Wish List .
Quality Antiques and Fun Collectibles at Reasonable Prices
Antiques, collectables, Oriental, sports, books,Christmas year around, and more


text:
I have faith that Elvis is alive, Oswald did not act alone, and individuals shiny satellites up on the horizon should be the dirty government attempting to hijack the brain. It is a frightening, misleading world available, folks.
But worse than everything, there's one conspiracy that actually has my tulsi inside a chiffonade commercial eateries want us to fail. You heard right. Why else would restaurants, bars, and frozen treats shops setup business right beside gyms and weight reduction centers? They already know we packed around the Pounds this holiday which we are scrambling to those places to fix the issue. Hey, the putting on weight is not totally your fault. This friggin' blog has you creating a new recipe virtually every day. The Finnish sauted reindeer, bourbon eggnog, and pork and cheese casserole made you body fat, however your New Year's resolution (exactly the same one you have made within the last 10 years) may have you in your tapered skinny jeans very quickly.
To demonstrate my conspiracy theory, I drove around (in disguise with changed license plates, obviously) and located a couple of companies which are to enable you to get.
LA FitnessOn the best way to boxing class in the LA Fitness in Coconut Creek, you'll pass four eateries pleading for the business. Following a Cheesecake Fantasy frozen treats waffle cone, Ropa Vieja, a Smokehouse Poultry sandwich, along with a slice of pepperoni pizza, you ought to have plenty of energy to roundhouse up bad weather.
Shuck N Dive really wants to fill your core with Cajun evil.
Bikram yoga is actually great for your core. Guess what happens else is? Cajun Creole Southern soul food goodness in the Shuck N Join in Fort Lauderdale.


text:
Sometimes when I see all the beautiful quilts on here, I think, I would never have thought of those colors together, and somehow they work. Maybe I am just color challenged.
Welcome to the Quilting Board!
Sometimes when I see all the beautiful quilts on here, I think, I would never have thought of those colors together, and somehow they work. Maybe I am just color challenged.
Me too! I think coordinating fabrics is the hardest for me.
instead of worrying about colors try making a quilt with just values...light-medium- and darks with no regard to color what so ever...you may find it liberating and learn alot about putting colors together. i know in fashion we would (laugh) about someone wearing plaid pants with a flowered shirt and a striped vest...but in quilting you can put all of those together just fine and beautifully.
I feel the same. I think scrap quilts would be the hardest...I see some here that are just beautiful though.
That's why I make scrap quilts because I have a hard time coordinating colors.
Get the book "Color Magic for Quilters" . It's great and helps a lot. Check amazon for a used one.
I was in retail- both fabrics & ready-to-wear & I always thought I was pretty good at putting colors together, but I felt a lot of my quilts were pretty blah. I tend to try to coordinate too much & am beginning to concentrate more on contrast. Still learning, I guess!
This was the hardest part for me too, when I started quilting, and that was less than 5 years ago. I read Color from the Heart by Gai Perry and did some of the exercises in the book. (Okay, I admit I only did one exercise, but I read the others and did them in my head, LOL)Originally Posted by trueimage
Then I just practiced, and looked at other quilts, and practiced some more, and now people tell me I am good at putting fabrics together. Me! I thought I had no color sense at all. Now I love putting fabrics together. This is a skill that can be learned, and if I could do it then anyone can.
Also, I find that scrap quilts are the easiest - IF you let them be scrappy. Just put the fabrics together without looking at the color, paying attention only to lights and darks, and it WILL work out.
I stink at putting colors together - so scrap and monotone is the only comfortable thing for me. I also have a problem with lights - I think they "come forward" too much. I'm trying ... have read all the books ... but still tend to stay in the "medium" range no matter what. Scared? Not enough selection at Joann's? Need to branch out - any suggestions?
Find a piece of fabric that has a lot of different colors in it that you just love.
Then look for all of those different colored fabrics in different sized prints/designs/tonals etc...
Just use these pieces in a quilt, not the original fabric that you pulled the colors from. If they all look good together in that fabric, they will all look good together in a quilt too :D:D:D


text:
ISIS (ISIP): Lou Gehrig's Disease Antisense Drug Has Reached Clinical Trials
Isis initiated a Phase 1 study of its antisense drug ISIS-SOD1Rx in patients with an inherited, aggressive form of Lou Gehrig's disease also known as familial amyotrophic lateral sclerosis. (ALS). As ISIS-SOD1Rx selectively inhibits the production of SOD1, it is expected to benefit the cases of familial ALS that are related to mutant forms of superoxide dismutase, or SOD1, which constitutes approximately 20% of ALS patients suffering from familial ALS.
In preclinical studies, using the drug ISIS-SOD1Rx, Isis, in collaboration with Timothy Miller, Don Cleveland (University of California, San Diego), and Richard Smith (Center for Neurological Study) were able to lower the production of SOD1 in neurons and surrounding cells, which seemed to have prolonged life in rats that showed many symptoms of ALS. In December 2007, the FDA granted ISIS-SOD1Rx Orphan Drug designation for the treatment of ALS.
Because antisense drugs do not cross the blood-brain barrier, Isis is administering the drug through a small pump directly into the cerebral spinal fluid - a drug delivery procedure known as intrathecal infusion.
Professionals demonstrating enthusiasm to the news include:
Merit Cudkowicz, M.D., Co-Chair of the Northeast ALS Consortium and a Professor of Neurology at the Massachusetts General Hospital of Harvard Medical School.He said, "There is a desperate need for new and more substantive treatments for ALS patients. The mission of the Northeast ALS Consortium is to help advance new therapeutic options for patients with ALS, and I am very pleased to be a co-chair on this important study evaluating ISIS-SOD1Rx in people with familial ALS."
Timothy Miller, M.D., Ph.D., Assistant Professor of Neurology at Washington University School of Medicine and Director of the Christopher Wells Hobler Laboratory for ALS Research at the Hope Center for Neurological Disorders said, "This is the first study to administer an inhibitor of SOD1 directly into the central nervous system. Having been involved with Isis in the research and now the clinical development of ISIS-SOD1Rx, I am looking forward to co-chairing this study with Dr. Cudkowicz and the Northeast ALS Consortium." Commenting on the drug, Dr Miller said, "It is evident that certain cases of familial ALS are related to mutant forms of SOD1. Therefore, the selective inhibition of SOD1 production could provide a way to improve the outcomes of these patients with ALS. "
ISIS-SOD1Rx is the firm's first antisense drug to enter clinical trials to treat a neurodegenerative disease and its first antisense drug to be administered directly into the central nervous system. Based on earlier preclinical studies, the firm expressed its belief that ISIS-SOD1Rx could offer an effective treatment for patients with familial ALS.
Prohost Biotech considers good news any successful efforts that bring rational evidence-based treatments for ALS into clinical trials. The disease is deadly and still eluding scientists, researchers and drug developers. There seems to be various etiologies for this disease with abstracts published about some discoveries, which we will tackle later in a future article. As we see with Isis' drug ISIS-SOD1Rx, it is a fact that no one single targeted drug will help all Lou Gehrig's disease victims.
We appreciate Isis news.
To learn more about the study click the following link: ISIS Initiates Phase 1 Clinical Trial of ISIS-SOD1Rx in Patients With ALS
Genzyme has a right of first negotiation to license ISIS-SOD1Rx from Isis.
The ALS Association and the Muscular Dystrophy Association are providing funding for the development of ISIS-SOD1Rx.
ISIS is still trading at less than $9, with a market cap of 876.63 M.


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Gold, frankincense and myrrh are all very well, but will they bolster your investment portfolio in 2004? Peter Weekes reports.
You've bought the gifts to put under the tree, but what about those last-minute stocking fillers? Why not try coffee beans, a gold coin or two, or shares in the unloved Mayne Group.
These are some of the suggestions from financial planners, stock watchers, financial astrologers and futurists.
With only five shopping days until Christmas, author and financial planner Harold Bodinnar says that whether the gift is for a man, woman or child, you can't go past the international bestseller The Richest Man in Babylon by George Clason.
Based on the famous "Babylonian principles", it's been hailed as the greatest of all inspirational works on thrift and financial planning. "In short," says Bodinnar, "it can set you up for life." Distributed in Australia by Penguin books, it sells for $18.95.
For the studious, the president of the Australian Shareholders Association, John Curry, recommends Don Watson's Death Sentence: The Decay of Public Language, as it highlights the jargon in companies' annual reports that is designed to baffle, and the more straightforward The Essays of Warren Buffett: Lessons for Corporate America.
If books are not your thing, KPMG partner, futurist and best-selling author Bernard Salt has drawn on his research into Australia's changing demographics to find ways for savvy investors to make a buck or two from the oldies.
He suggests buying a property in Northcote, after media reports that actress Sigrid Thornton may stand for the safe Labor seat.
"Sigrid Thornton has demographic form," Salt says. "She kick-started a property boom in Echuca after she starred in All the Rivers Run, which was filmed there in 1987. She did the same to Barwon Heads when her SeaChange series was first released in 1998."
The so-called Sigrid Effect, in which the population of a town booms after she visits, may just catapult the value of residential property in Northcote, Salt says.
And at the other end of the age scale, he predicts babies will become the "petrol-guzzling four-wheel-drives that well-to-do baby boomers lusted after in the 1990s."
He argues that as boomers continue to distort the social agenda in favour of middle-aged youth - 40 is the new 30 - babies are becoming increasingly rare.
This scarcity will make them the fashion item of the upwardly mobile, much the same way that the success of the anti-smoking lobby made cigars and even yuppie cigar bars popular.
Be prepared for the future and give stock in Johnson & Johnson, he says.
Needless to say, Pfizer shares are high on his list of gift ideas. Weight loss, hair replacement, cosmetic surgery and dentistry will flourish as we try to confuse mutton with lamb, and of course there will be a constant need for Viagra to stave off flagging masculinity.
Talking about flagging, astrologer Lorraine Rubin predicts the stockmarket will have a rough time next year, particularly in October, as it heads to the bottom of an astrological cycle, but some shares will perform better than others.
Using companies listing dates as their birth dates, Rubin has done the charts and recommends shares in Adelaide Brighton, Structural Systems and Ross Human Directions.
Her US colleague Ray Merriman, who will speak at the Australian Astrologers conference in Melbourne next month, says that with Uranus moving into Pisces next year, it's time to emulate the Wise Men and give gold this Christmas.
Jason McIntosh, the co-founder of stock watchers Fat Prophets, agrees, though for different reasons. He says you should fill your stockings with as many pieces of gold as you can as they will increase in value next year.
He also predicts the price of coffee beans will jump in 2004, along with shares in mid-sized gold producer Empire, down-on-its-luck blue chip Mayne Group and debt collector Collection House. But if you would rather bulk out the stocking, financial planner Warrick Dickson of Haines Muir Hill suggests a bottle of 1991 Hill of Grace. "Even if it doesn't appreciate, it will still be fun to share with friends," he says.
Then there is always the safe option - cash. Financial planner Kevin Bailey says people should consider holding their cash balances in a highly liquid form, particularly when further interest rate rises are expected. He says ING is now paying 5 per cent on "at call" money, with no entry or exit fees.
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Trinity Episcopal School seeks a highly qualified Marketing Coordinator.
Trinity Episcopal School is a progressive, independent day school with approximately 500 students in kindergarten through eighth grade located in Westlake Hills, close to downtown Austin, Texas.
Provides day-to-day marketing support to the Marketing and Communications team in their work to create integrated marketing campaigns. This position reports to the Director of Strategic Marketing and Communications and works closely with the Content Marketing Manager.
The role requires responsive customer service, outstanding project management skills and attention to detail.
To apply:
Send resume and cover letter to Human Resources at Trinity Episcopal School, 3901 Bee Cave Road, Austin, TX 78746, or email to email@example.com. Applications will be reviewed upon receipt and accepted until the position is filled. No phone calls please.
Trinity Episcopal School provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws.
Trinity Episcopal School complies with applicable state and local laws governing, non?discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence.


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Turquoise bay really is a gr8 place for snorkeling, with the right camera you can get some pictures fo the glittery fish. Take a guided tour for diving in the Great Barrier Reef if you havn't done any diving before.
The Coral Coast
Trip Start Mar 02, 2010
82Trip End Oct 29, 2011
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My fishing charter turned out to be both good and bad. We took the boat all the way out past the reef and began fishing, but the water was so choppy that the captain couldn't achor properly and fishing was too difficult so we turned around and went back
After everyone had got their fill of diving, and snorkelling, etc. we headed off further up the peninsula to Cape Range National Park. This is a park right in the heart of the Ningaloo Reef so there were good beaches and snorkelling to be had. It's a bit competitive to get camp sites since it's all done on a first come first serve basis. So we stayed at a caravan park, called Yardie Creek the night before heading to the park. It was also a good spot to do some laundry and have a BBQ! The next morning, we got up early and got in line for a camp site which we ended up getting without any trouble.
In the park we did a couple hikes, such as the Mandu Mandu Gorge, but mostly spent our time swimming and snorkelling because that's the real attraction. Turqouise Bay, which looks as nice as it sounds, was probably the best spot to go snorkelling. There were some other good spots, like Oyster Stacks, but at most other places there was either a bit too much current, or it was a bit rocky getting in and out, so we spent most of our time at Turqouise Bay.
The park was also good (or maybe bad, depending on how you look at it) for wildlife
After we'd got our fill of Cape Range, we headed back to Exmouth, where Brooke and I decided to crash at a caravan park. This was a pretty good deal for the $15 a night we paid. We had all the essentials like laundry and a BBQ as well as a huge and very refreshing pool just a minute from our tent! So it was good for us to stay here for a few nights and BBQ, swim and relax with a few drinks before heading off to Karratha and then Karajini National Park.
Post your own travel photos for friends and family More Pictures
Turquoise bay really is a gr8 place for snorkeling, with the right camera you can get some pictures fo the glittery fish. Take a guided tour for diving in the Great Barrier Reef if you havn't done any diving before.


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Life's in a hurry. Blink and your babies are starting school, getting married, and presenting you with grandkids. Turn around and that great party is in the history books. Barb Bergeson Studio Gallery wants you to push the Pause button. We know that life is fun and wonderful and we are passionate about using our camera to give you a moment you'll always be able to celebrate. We are a full service studio, let us help you remember your life in vivid detail.
How would you like to Pause Life today?
- I would like to capture the beginning of life for my sprouting baby, or belly.
- I would like to capture my children or family as I see them.
- My business head shot doesn't fit me anymore, I need a new one.
Our Philosophy
We don't have a fluffy saying of why we started in photography, we just love what we do and because of our experience, professionalism, and creativity, we will create stunning portraits that can be hung on your wall.


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|473 sq. ft.
|Property type
|Minimum Stay
|2 - 7 nights
New Barn has a downstairs double bedroom and twin beds upstairs. The property also has a fully fitted kitchen, bath and shower and a small living room area. Enjoy wonderful walking, cycling and nature rambling directly from the property. The pretty village offers a pub and shop.The property is an excellent base to visit historic Salisbury, Stonehenge, Bath and the coast. Additional attractions further afield include Longleat, Stourhead and Winchester.
We have 3 children and a friendly black labrador. We live next door to New Barn but there is plenty of space for everyone in the large garden.
Emma Flint purchased this house in 2011
We have lived in the area for many years but we moved to Broad Chalke in 2011 so that we could be closer to Salisbury and schools for our 3 children. The village is a very friendly community and we quickly found ourselves involved with the village tennis club, shop and village hall. One of our daughters spent Easter helping a local farmer with lambing.
New Barn and Mead House are located in a wonderful setting facing due south. We have beautiful views over the water meadows across the River Ebble to the village church. You can walk or cycle direct from the property with a choice of dozens of different tracks and paths to explore. Alternatively, take a stroll through our enchanting village to the watercress beds to buy fresh watercress and some free range eggs or local honey.
Emma and her husband could not do enough to make our stay more comfortable. The barn is clean, cosy and felt just like home.... lovely gardens to relax in were a bonus
Broad Chalke itself offers a great country U.K. experience. Thatched houses, nice pub and stunning views.
Fab location and house. Perfect for a family of 4. Owners very friendly. Perfect for access to many towns, villages and attractions including Salisbury and Stonehenge.
Spent 2 nights at this lovely property. Emma couldn't have been more helpful and we really appreciated the little extras, bacon and eggs, toiletries in the bathroom etc. Also thank you for access to all the toys, our 3 year old was in heaven! Hope to stay again next year.
A lovely, well maintained cottage with modern kitchen and bathroom, containing everything we needed. The children's bedroom in the loft was spacious and comfortable, as was the master bedroom downstairs. No real living-room, but lots of outdoor space. The owner was generous and accommodating, supplying an extra bed at no extra charge. Great location with fantastic walks and very near Salisbury too.
My wife and I and my wife's parents stayed for one week. New Barn was excellent, clean and comfortable and a perfect base for touring the Salisbury area. Emma managed to retain a low profile yet was always available if we needed help. Lots to do and see and when it rained (which it did quite a lot) there were some interesting stately homes within a relatively short drive. Would highly recommend.
New Barn had everything that we could have asked for as a base for our young family for our trip away over the bank holiday. It was clean, spacious and light with lovely views all around and cows at the end of the drive which the children loved. Emma was very welcoming, accommodating and available, all in all a wonderful host, who even left some liebnitz for us in the welcome pack! I would highly recommend New Barn to anyone looking to spend some time away in Wiltshire.
New Barn is situated on the edge of the picturesque village of Broad Chalke in the renowned Chalke Valley. Visitors can walk, cycle or drive from the property along a variety of tracks and paths into the surrounding hills and explore the chalk downland. The medieval city of Salisbury is little more than 10 minutes away and attractions here include Salisbury Cathedral, independent shops and market, theater, cinema and restaurants. Stonehenge and Salisbury Plain are located just 25 minutes away and are popular with visitors.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
High Summer
1 Jul 2017 - 2 Sep 2017
7 night minimum stay
for 7 nights
My Standard Rate
2 night minimum stay
for 2 nights
|No additional mandatory fees
|Refundable Damage Deposit


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Miller & Carter Ruislip
154 Bury Street, Ruislip, Greater London, HA4 7TH
154 Bury Street, Ruislip, Greater London, HA4 7TH
Steak isn't the only thing we're selective about at Miller & Carter Ruislip. We also take great care in crafting a drinks list that perfectly complements all of our dishes.
Whether it's a rich barolo with an intensely flavoured ribeye, or a silky smooth pinot noir to partner a subtly flavoured fillet, when it comes to matching wine with steak it just has to be red.
That's not to say our wine list doesn't include plenty of well-chosen white, rosé and sparkling wines by the glass and bottle. And there's no better way to break the rules than with champagne and chateaubriand to share
Cocktails are also a speciality. Our bar tenders mix a mean Steakhouse Sour, alongside other classics and their own modern creations. Or if beer is your preferred tipple, you'll find premium continental lagers on tap as well as a good bottled selection. Plus we've a variety of spirits, soft drinks and coffees.


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|Irish Coffee: Celtics weary, even on rest
|04.12.11 at 11:44 am ET
Mercifully, the Celtics have no more back-to-back games. After recording an 8-11 record in 19 back-to-backs this year — including a 2-8 record in their last 10 — the C's won't be playing on consecutive nights in the playoffs. So, just how much better are the Celtics with one or more days rest?
Before we attempt to answer that, it's important to consider these three things:
- 1) The Celtics have allowed an NBA-best 91.0 points per game, and even in back-to-back games they held opponents to an average of 92.3 points, which still would've ranked third in the league this year.
- 2) The Celtics scored 96.3 points per game, ranking 24th out of 30 NBA teams. In back-to-backs, they averaged just 91.6 points a game, which would've ranked last in the league this season.
- 3) While the 2011 NBA Playoff schedule hasn't been released yet, in their 24 playoff games last season the Celtics played 14 on one day rest, six on two days rest and four on three or more days rest.
- 4) The Celtics will go as far as the Big Four take them. Plain and simple. And considering Paul Pierce, Ray Allen, Kevin Garnett and Rajon Rondo are the only C's to play 30-plus minutes a night, they're in need of the most rest.
Now, let's compare the Big Four's performances on one, two, three or more days rest as opposed to their numbers in back-to-back games. How significant is their improvement with fresher legs (individual bests in bold)?
- Totals (80 games): 34.7 min, 18.9 pts, 49.7 fg%, 37.4 3p%, 86.0 ft%, 5.4 reb, 3.3 apg, 2.1 to
- 0 days rest (18 games): 35.7 min, 19.0 pts, 46.4 fg%, 41.4 3p%, 88.9 ft%, 5.9 reb, 3.2 apg, 2.3 to
- 1 day rest (42 games): 34.0 min, 18.9 pts, 50.5 fg%, 36.3 3p%, 83.4 ft%, 5.2 reb, 3.0 apg, 2.2 to
- 2 days rest (14 games): 36.4 min, 17.6 pts, 47.0 fg%, 26.3 3p%, 87.0 ft%, 5.1 reb, 4.2 apg, 2.1 to
- 3+ days rest (5 games): 31.6 min, 22.0 pts, 61.2 fg%, 57.1 3p%, 94.1 ft%, 4.8 reb, 3.2 apg, 1.2 to
|Game Preview: Celtics vs. Pacers
|02.27.09 at 1:24 am ET
On Friday the Boston Celtics (46-13) will return to the TD BankNorth Garden to take on the Indiana Pacers (25-35). It has been nearly three weeks since the Celtics played on their home court, and since then a lot has changed:
- February 13-15: Big Three participate in All-Star Weekend
- February 17: Sam Cassell traded to the Sacramento Kings
- February 19 (day): Patrick O'Bryant traded to the Toronto Raptors
- February 19 (night): Kevin Garnett strains right knee; Celtics lose 90-85 to Utah Jazz
- February 22: Rajon Rondo celebrates 23rd birthday with 32 points in 128-108 win over Phoenix Suns
- February 23: Brian Scalabrine suffers cervical strain; Celtics beat Denver Nuggets 114-76
- February: 24: Stephon Marbury is bought out by the New York Knicks; Mikki Moore signs with the Celtics
- February 25: Moore debuts; Paul Pierce dislocates right thumb; Celtics lose 93-91 to Los Angeles Clippers
- February 26: Gabe Pruitt is arrested in LA for suspicion of DUI; Marbury tells New York Times he will sign with Celtics and be in uniform on February 27
The actual game between the Celtics and Pacers is overshadowed by the question of whether or not Marbury will be a Celtic prior to tip off. While the Celtics may make an addition, both teams are shorthanded. Garnett (knee), Tony Allen (thumb), and Brian Scalabrine (neck) are unavailable for the Celtics. Danny Granger (foot) and Mike Dunleavy (knee) will not play for the Pacers. The Celtics are 2-1 since losing Garnett. The Pacers are 3-1 without Granger.
Tip-off is at 7:30 EST.
|Nike All-Star Kicks
|02.10.09 at 8:33 pm ET
Nike is rolling out a special line of sneakers for the 2009 NBA All-Star Game, including a pair for Paul Pierce. The shoes will be red and blue to match the Eastern and Western Conference uniforms. There will also be artwork to represent the host city of Phoenix, Arizona. Check out the shoes and a list the players who will be wearing them, from NiceKicks.com.
Eastern Conference: Chris Bosh (Nike Huarache 09), Danny Granger (Nike Zoom Phenom, not pictured), LeBron James (Nike Zoom LeBron VI), Rashard Lewis (Nike Hyperdunk), Paul Pierce (Nike MAX P2 V, not pictured)
Western Conference: Kobe Bryant (Nike Zoom Kobe IV), Pau Gasol (Nike Hyperdunk), Dirk Nowitzki (Nike MAX Spot Up), Brandon Roy (Nike Zoom Phenom), Tony Parker (Nike Huarache 09), Amare Stoudemire (Nike Foamposite Lite), David West (Nike Foamposite Lite)
|Pierce's D Helps Celtics Earn the W
|12.03.08 at 9:24 pm ET
The stat line will tell the story of Rajon Rondo's triple-double, Ray Allen's 31 points, and Kevin Garnett's 14 rebounds. But what it won't show is the stifling defense Paul Pierce imposed on Danny Granger. Pierce held Granger to just six second half point (20 total) and shut down the Pacers leading scorer.
'Paul's always been a good defensive player,' Granger said after the Pacers 114-96 loss. 'KG's a candidate for Defensive Player of the Year and I think that's one of the things that makes this team good. They can score the ball but they also play good defense.'
Granger scored 14 points in the first half with the majority coming while Ray Allen was guarding him. The defensive switch worked for the Celtics and Granger finished the night shooting 7-for-15, including just one basket in the paint. Pierce's tough defense combined with the Pacers' exhaustion from Tuesday's overtime win against the Lakers was too much for Granger to overcome.
'I just got a little tired,' he said. 'It's hard playing back to back games sometimes, especially when you fight so hard to win one game. You have lapses and your legs give out but that's still no excuse. Everyone plays back to back games. You've just got find a way to find through. Tonight we couldn't.'
|Preview: Boston Celtics vs. Indiana Pacers
|at 9:25 am ET
On Wednesday night the Boston Celtics (17-2) will take on the Indiana Pacers (7-10) at the TD BankNorth Garden. The Pacers already upset the Celtics once this season and are riding the momentum of stunning the Los Angeles Lakers on Tuesday. It will be up to the Celtics to halt this series of shockers.
What Went Wrong
On November 1 the Pacers defeated the Celtics 95-79 in Indiana. It was the Celtics first loss of the season, quickly proving their championship didn't make them immortal. The Pacers jumped out to a 10-point first quarter lead and went up by as many as 25 in the fourth. The Celtics looked sloppy on the road (24 turnovers) and were off the mark all night (34.6% FG, 4-for-20 3PG, 60% FT). Kevin Garnett and Paul Pierce's combined 33 points and 24 rebounds were not enough. Kendrick Perkins went scoreless while Rajon Rondo hit just one basket. Danny Granger scored 20 points, Marquis Daniels posted 13 points and 11 boards, and T.J. Ford contributed 19 points. When asked to explain the 18-point loss, Garnett told the media, "I don't even know what to call it."
In the Last Five Games …
The Celtics have the offensive edge over the Pacers, stretching their margin of victory up to 14.2 points per game over the last five contests while the Pacers have been losing by an average of 4.4 points. Their offense is back on pace with their defense (51.4% FG, 40.3% 3PG) as the Pacers have ranked in the bottom half of the league (43.8% FG, 34.8% 3PG). But in spite of the Celtics stifling D, the Pacers are the best rebounding team in the NBA and average nearly 10 more boards (49.0 to 40.0 rpg). The Pacers have also been the better ball handling team (23.0 to 21.8 apg) as of late despite Rajon Rondo's impressive play.
More than Meets the Eye
The Pacers 7-10 record is deceiving. This team has individual talent and has proved they can be threatening when playing together. Danny Granger is one of the hottest players in the league today and he and Paul Pierce will challenge each other on the perimeter all night. Force him behind the arc, though, and the Celtics could stifle his game. He is shooting just 24% from long range on no days rest. The Pacers traded Jermaine O'Neal for T.J. Ford this summer for backcourt leadership. Ford is just as dangerous as Ray Allen from the line and is capable of dropping 20 points on any given night. Troy Murphy (11.0 ppg, 11.8 rpg) will challenge the Celtics on the glass as one of the league's underrated big men. Marquis Daniels is also having a breakout season (16.1 ppg, 6.2 rpg) after recovering from a foot injury.
Hitting the Bench
While Jeff Foster and Jarrett Jack have been reliable for the Pacers off the bench, the Celtics reserves have the advantage. The Cs bench is filled with championship winners whereas the Pacers bench includes inexperienced rookies and unproven journeymen. Tony Allen has been explosive at the basket and scored 14 points in the first game against the Pacers. After suffering their first loss in Indy, the Celtics starters will look to come out swinging and that intensity will trickle down the bench.
Check back tonight for WEEI's Live Celtics Game Day Blog from the TD BankNorth Garden.
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HOMER-CENTER: History Bowl team advances to national competition
HOMER CITY — It's that time again; the time where we get to recap all of the events that have happened at Homer-Center High School recently.
In history-related news, Homer-Center High School's junior varsity History Bowl team earned a trip to the National History Bowl in Akron, Ohio. They earned second-place honors in the regional qualifier on March 22, a job well done. Homer-Center's Nick Silveri, a member of the History Bowl team, was selected as MVP for the team and as a result, he will compete in the National History Bee in Washington, D.C., later this month, as well as the U.S. Geography Challenge in Washington, D.C.
[PHOTO: Members of the junior varsity History Bowl team, from left, are Ben Wolford, Steve Novak, Nick Silveri and Rick Orr. (Stephanie Myer photo/Homer-Center High School)]
Homer-Center's indoor percussion band, Homer-Center Nuclear Percussion, has made some quite impressive feats of accomplishment as well. On March 22, the band placed first for the second time this season in a Johnstown competition. The percussion group is ranked at a solid sixth place out of all other percussion groups from various eastern states such as Delaware, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Virginia and West Virginia. That's more states than their own ranking. This is certainly a very special accomplishment for Homer-Center's musical department, and the support for their continued efforts beats onward.
Emerie Stagner, a member of Homer-Center Nuclear Percussion, said, "It's been a lot of hard work for us, as we have been putting a lot of hours into each week for practice. However, it's been well worth it, especially when we heard that we're sixth out of many different teams across several states. Also, seeing the looks on many of my friends' faces after hearing the news was priceless."
Raising Drug awareness
A few weeks back, an assembly was held in order to raise awareness. Raise awareness for what, you might ask? Well, it has been said that narcotic drugs, specifically heroin, have been on the rise in our area. That statement is as scary as it is real, and so Homer-Center High School held an assembly for all students. This assembly wasn't just about heroin though, as it also stressed the importance of staying away from any drugs. So, on March 20, students and faculty were gathered in the auditorium in the afternoon to share some words.
The assembly started off with a video that included many interviews and perspectives on certain scenarios where teens and young adults were living a life around heroin. The video really showed how far these victims went in order to live with their addiction. Those who started the drug said that, as many others would agree with, it wasn't about getting high after some time. Those who do drugs such as heroin are known to experience a term that was often coined as "dopesickness." This was a way to describe the pain and sickness one feels when they are not putting the drug into their system.
Another point that was brought up was that many people lost their life, as an addiction to heroin can be just as deadly when you're sober. Many victims would eventually get help, but then relapse. They would get high off the same drug, but the tolerance they had built up before wouldn't be as high, so when they took the drug, they would take enough that harmed them more than usual. In several cases, the amount they took was enough to cause death. All it took was one injection, from the very first point, and these heroin addicts began living their life on a downward spiral; however, some managed to fight through the addiction.
In addition to the video that stressed the importance to never even try a drug like heroin, some guest speakers came in to talk about their own stories. Carmen Capozzi, of Irwin, the president of Sage's Army and the father of Sage Capozzi, who lost his life due to heroin, spoke of his own experiences with many people who struggle with addiction. In addition, two past users came to tell their personal stories.
Haley and Matt, both in their early-to-mid-20s, spoke about how they got involved with heroin and what they have been doing to stay sober.
One thing they kept referring to, though, was that they noted their addiction as a disease. It wasn't something that they were done with, and both Matt and Haley feel as if they are diseased as a result. Thankfully, the two are doing much better than they were before, as Matt has been sober for about six months and Haley for about two years.
When asked about why they refer to their addiction as a disease, both responded with, "We call it a disease because it has become a disease. We have to watch it and regulate it, and take proactive steps in order to prevent a bad reaction. We use the term disease to remember the consequences that had occurred, and to remember that if we're not careful, the consequences can come back."
The constant tug-of-war battle with addiction that many people face in their lives is certainly not a cheery one, but it is good to see more steps being taken in order to prevent more lives lost in such acts.


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If you have Medicare or are eligible for Medicare
Centers for Medicare and Medicaid Services
Website: www.medicare.gov
Toll-free number: 1-800-MEDICARE (1-800-633-4227). English- and Spanish-speaking staff are available at this number 24 hours a day, 7 days a week.
Medicare is the United States' health insurance program for people age 65 or older, although certain younger people with disabilities might also qualify.
This federal government website can help you sign up for Medicare (if you're 65 or older) and choose the right Medicare-approved prescription drug plan (called the Part D plan) based on where you live, your income, and the drugs you take. You can join a Part D plan during open enrollment if you already have Medicare Part A and/or Part B. If you had prescription coverage and recently lost it, you may be able to enroll at times other than open enrollment. Contact Medicare or check online to see if you can do this.
You may qualify for "Extra Help" if you have very limited income and assets but don't get Medicaid. If you qualify for Extra Help, you may not have to pay a premium, deductible, or co-payments for Medicare Part D. You can apply or get more information about this by calling Social Security (see the " To learn more" section). Some people automatically get Extra Help and don't need to apply, such as those who get Supplemental Security Income (SSI), or those who already have full Medicaid and Medicare.
If you're enrolled in a state pharmacy assistance program, including Medicaid, you will probably also be enrolled in Medicare Part D. If you have prescription drug coverage through your current health insurance or get discounts on your prescriptions through other programs, review your coverage closely to see if the Medicare drug plan will save you more money on your prescriptions.
If you don't qualify for Extra Help, Medicare also keeps a list of drugs that are on private prescription drug assistance plans. You can find the list on their website at www.medicare.gov/pharmaceutical-assistance-program/index.aspx. You can search by the drug name and find details on the programs and their contact information.
You can learn more details about the Medicare Part D drug plans and how to choose one in our document called Medicare Part D: Things People With Cancer May Want To Know. You can read it on our website, or call us to have a free copy mailed to you.
Medicare Access for Patients Rx
Website: www.maprx.info
Medicare Access for Patients Rx, called MAPRx, links you to information about Medicare Part D, also called the Medicare Prescription Drug Program. It answers common questions about Medicare Part D, and has a state-by-state listing of other possible resources and programs.
MAPRx does not directly serve Medicare recipients, but it's a good, easy-to-use source of information about Medicare and drug coverage. Free fact sheets can be downloaded from the website or from related website links.
Prescription Drug Assistance Programs
- Prescription Drug Assistance Programs
- To get help paying for your prescriptions
- If you are 55 or older
- If you have Medicare or are eligible for Medicare
- If you have limited income and no drug coverage
- If you have health insurance
- If your income is low: Look into Medicaid
- Tips to save money on prescription drugs
- If you're thinking about buying drugs online
- Other ideas to explore
- Applying for a patient drug assistance program
- If you don't live in the United States
- To learn more
Last Medical Review: October 28, 2014 Last Revised: November 13, 2014
American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.


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Wrestling Forum : WWE, TNA, Indy Wrestling, Lucha Underground, Women of Wrestling Forums (http://www.wrestlingforum.com/forumindex.php)
- Mafia Archive (http://www.wrestlingforum.com/mafia-archive/)
- - Space Jam Mafia Discussion Thread (http://www.wrestlingforum.com/mafia-archive/410976-space-jam-mafia-discussion-thread.html)
Space Jam Mafia Discussion Thread
All discussion for the game will go in here. Most of the other relevant gameplay posts will go in the Gameplay threa. I'll keep the list of players here, and in the other thread, as well as the current phase of play (day or night).
Player List
11 2Slick - Replaced by DDJ
12 DHoop6
19 Postage
Here are a brief couple of rules and pointers:
- No rep begging. I'll hand out rep (+106) when the servers are back up frequently if you are playing well.
- Stay active! Don't sign up if you don't plan to be active. If not, -53 and a very bad player review for you :no:
- Role revealing is allowed, character revealing isn't. However, if it is specified you can't role reveal, then don't, or you'll be modkilled. Make one up if necessary, check the role thread. It is wise not to role reveal unless it is the only thing that can stop you being lynched.
- The obvious idea of the game is to convey yourself as innocent. The majority of the players are innocent, so for God's sake if your Mafia or Individual, don't tell anyone.
- No communication outside the thread, full stop. Obviously Mafioso are allowed to do so, but innocents and individuals are certainly not allowed.
Space Jam – 25 players
Toon Squad (Innocents)
The Monstars (Mafia)
NBA Allstars (Individually aligned)
Current Phase: Day 1
Have fun and enjoy the game. Make sure you stay active. If you're interested in becoming a reserve, please state so. We do need reserve players and certain people will be inactive. Keep this thread active!
Re: Space Jam Mafia Discussion Thread
When should I expect to receive my role?
Re: Space Jam Mafia Discussion Thread
Roles are being sent out at the moment. Will take me up to 40 minutes to send all 26.
Re: Space Jam Mafia Discussion Thread
Ok good stuff and all that jazz.
Sending out them role pm's must be a real bitch:p
Re: Space Jam Mafia Discussion Thread
Surely your gonna have to do it though CF :p?
Re: Space Jam Mafia Discussion Thread
Great to see this game up and running so quick Seb, I feel this will be a very well moderated game on your part.:)
Re: Space Jam Mafia Discussion Thread
Re: Space Jam Mafia Discussion Thread
He has a point, no clues, who would be lynched?
Re: Space Jam Mafia Discussion Thread
It's usually Postage :p
I'm going through the sign up thread, so those who signed up quickly will get their roles first.
You're right, it is a fucking bitch. Especially seeming as it's 1 PM per minute so I can' do a load at once :(
Re: Space Jam Mafia Discussion Thread
He has a point is so far as there's no clues.
I really don't trust/like clues anyway. No lynch rarely helps town either.
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text: As a young mother I used to feel that way, the wash never stayed clean, the dishes dirtied faster that I could wash them and my 2 little girls always needed a piece of me. Those were the days when I tried to be all things to all people and that is a very draining position to hold. Years have passed and besides getting older, I have learned that dirty dishes and wash will continue to accumulate just like the leaves falling from the tree BUT the people that want a piece of me are now my grandchildren and they take priority. I will not always be around, they will grow up and move on with their lives which is the natural cycle of things...but for now, I have them, they have me...as for the leaves, let em fall!


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March 8, 2012
Bodybuilders know the price of physical perfection is pain. They know that rough sets, aching muscle bellies and torturous cravings are all part and parcel of being big and lean. But sometimes this pursuit can have much more damaging effects. The dog-eat-dog nature of the industry can be unforgiving, leading many to take shortcuts via the use of anabolic steroids. And while the side effects are always fodder for debate, there's a clear and medically proven tie between the use of such drugs and one particular condition.
Gynecomastia, or the unsightly enlargement of male breast tissue, has a wide range of causes but chief among them is steroid use.
"While it's estimated that somewhere between 40–75% of the male population has some form of this condition, and most of the time the cause is unknown, it generally occurs from an imbalance in hormones where there's an excess of estrogen and a decrease in androgen," says Sean Rice, MD, FRCSC, a Toronto-based cosmetic surgeon.
There's no easy fix or wonder drug that can help mitigate this condition in adults. You may be willing to suffer the daily toil of the gym but unless you're prepared to endure the physical and psychological fallout of a C-cup existence, it's time to educate yourself on the pectoral scourge of a generation.
In bodybuilding, building big pecs is part of the assault in the gym, why you spend hours on the bench press. There is, however, a wide difference between big pecs and the more unpleasant appearance of gyno, or "bitch tits."
"Gynecomastia can occur in one or both breasts," says Rice. "This enlargement can be due to excess of glandular tissue or excess fatty tissue. In my experience it's generally a combination of the two."
How do you separate cases of gyno from plain old, saggy, underdeveloped chest muscles? There are a few telltale markers.
"There can be great variability in the appearance of the breasts," says Rice. "Those with mild conditions generally have some puffiness just under the areola, the dark area that surrounds the nipple. Those with more extreme cases can have breasts that closely resemble those of a female. The great majority of cases lie somewhere between the two extremes. In my experience those with very large breasts have an overabundance of fatty tissue. In mild cases it almost feels like a golf ball under the nipple — firm and hard. And in these cases, it's almost always due to an excess of glandular tissue."
While it's true that some cases are just the result of losing the genetic lottery, there's a high incidence of gynecomastia in the drug-using bodybuilding population. It all has to do with your body's hormonal responses.
"There's a long list of drugs that have been associated with the development of gynecomastia," says Rice. "But steroid use is a common reason for gynecomastia in bodybuilders. Generally what happens is that steroids are androgenic, or male-hormone based. When someone takes steroids, the body senses the abundance of male hormones and then turns down or stops its own natural production. Then when the person stops taking the steroids, it takes the body some time to start producing its own testosterone again and [previously existing low levels of] female hormones take over, causing gynecomastia. For some people, this abundance of breast tissue never goes away."
Rice says that bodybuilders needn't worry about the heightened risk for gyno, that is, as long as they're clean. "Using steroids would increase your odds of developing gynecomastia significantly, particularly if you're sensitive to female hormones," he says, adding that said sensitivity is pretty impossible to predict.
Some guys might think the condition can be hidden, but indeed, even the most minor case can have huge psychological consequences.
"Gynecomastia can have drastic psychological ramifications on some men," says Rice. "This can be manifested in issues of body image and self-esteem. Some men don't want to take their shirts off in public places such as the beach. It can also affect sexual relations with one's partner as the man feels embarrassed by his appearance. This is generally not a condition that men talk about, but I feel that it's important for men to know these feelings aren't uncommon amongst a good percentage of their peers."
Some men will choose to shroud the problem socially by keeping their shirts on whenever possible. If no one else brings it up then it's not really problematic, they rationalize. But gynecomastia can be a symptom of a problem that goes beyond the kits they keep in their gym bags or the way they look in fitted Ts.
"The first point men need to know is that there are medical conditions that need to be assessed and ruled out by anyone who has this disorder," says Rice. "Men should first seek out the assistance of their family doctor to make sure there aren't underlying serious medical conditions such as breast cancer or testicular disease and also assess whether some of the medications they're taking may be a contributing factor of the disorder."
If you pass snuff with your doc and neither breast cancer or testicular disease are the cause then, Rice says, it's time to take a hard look in the mirror.
"Once all medical conditions have been ruled out, then the individual needs to look at his lifestyle," he says. "If they use steroids or recreational drugs and don't want to exacerbate the condition, then they need to ask themselves if this is something they should stop."
It's wrong to think that actual gyno can be corrected by simple dieting or doing more cardio. While fat can be reduced through proper food intake and regular exercise, gyno is a different case.
"As the fatty component of the breast decreases, even small amounts of glandular breast tissue can be noticeable," says Rice. "This can be very troublesome to some men as they work hard on their appearance."
So what's the answer? Stop taking your anabolic cocktail, if you're willing and able, seems like an easy first fix, but even then you may not be out of the woods.
"Even in certain cases when these drugs are stopped, existing gynecomastia may not regress," says Rice. "When all medical causes are ruled out the only treatment left is surgery."
Going under the knife may not seem like a viable or desirable option — no one likes being cut into and, at the very least, such a procedure will keep you out of the gym for some time. But Rice sees surgery as a safe and effective way to correct the condition.
"Once all medical causes of gynecomastia have been ruled out, the condition is now an aesthetic one," he says. "If the man decides against surgery, there's generally no danger in leaving the condition alone."
So what are the surgical options, and does the severity of the case dictate the approach by the surgeon?
"There are many different surgical treatments for it," he says. "In my personal experience, the treatment depends on two main factors. First, the ratio between the amount of fatty tissue and breast tissue and second, the amount of excess skin. In my experience, for the majority of men I've had in my clinic, we've had excellent results using a combination of laser-assisted liposuction and water-assisted liposuction."
This technique uses a combination of laser energy to melt the more troublesome glandular tissue as well as the fatty breast tissue, and then uses the water to wash it away.
"In cases of solid breast tissue alone, sometimes only a direct, surgical excision of the glandular tissue works," says Rice. "This is performed by making an incision from the 3 o'clock to the 9 o'clock position around the areola. This way the scar is generally well-hidden. I find the toughest conditions to treat are those men with very large breasts that closely resemble those of a woman. In these cases there's generally an excess of skin, fat and glandular tissue and in extreme cases a mastectomy procedure may need to be performed."
"I treat a lot of men who are hardcore gym users who want to return to pumping weights as soon as possible," says Rice. "They need to remember they just had surgery and they need to give their body time to heal and recover. The biggest issue with returning to the gym too early is that it may cause bleeding or excessive swelling that can prolong their recovery time and affect the aesthetics of their results."
So those chest-crushing loads on the bench taken to just below your nipple may not be such a good idea for several months — unless you want to revisit the emotional stress and physical pain caused by having gynecomastia.
The good news is that if you do have to have breast tissue removed, chances are you're out of the woods, barring extreme weight gain or a return to the use of substances that may have contributed to the gyno in the first place.
"Once the glandular tissue is removed, the recurrence rate for gynecomastia is low," says Rice. "On the other hand, if someone was to put on excessive weight there's a chance that'll increase the fatty component of the breast again."
So while there are many cases of men who had no choice in the matter, Rice's warning is clear: If you use anabolic substances, then you may have to cope with the consequences. And that may mean keeping that torso you're working so hard to show off under wraps … permanently.
Sean Rice, MD, FRCSC, is a Toronto-based cosmetic surgeon. For more information on his scope of practice, visit www.doctorseanrice.com.
Find out what category your man boobs fall into with this quick guide
The following is a condensed list of products have been linked to a increased incidence of gynecomastia:
Growth Hormone
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Swap Whole Grains for Refined and Reap Greater Health Benefits
Whole grains (WG), comprising wheat, oats, rice, barley, and quinoa, among others, are a major food group recommended by international dietary guidelines because of grains' association with reduced risk of type 2 diabetes and cardiovascular disease.
More Evidence That WG Are Good for You. New evidence from a study at Tufts


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CORAL GABLES, Fla. - The University of Miami's home finale Sat., Nov. 17 at Sun Life Stadium will be "First Responders & Military Appreciation Day". In appreciation of all first responders, Miami is offering them special discounted ticket prices.
UM invites all first responders, including police, sheriff's department, fire personnel, emergency medical technicians and military personnel to the Hurricanes' home finale against USF. To show our support, tickets regularly priced at $29 are now available for just $9. In addition, lower-level seats typically priced at $59 are available for only $28.
Each department who participates will be recognized on the stadium video board during the game. Simply tweet your photo to @HurricaneSports or email your photo to email@example.com. Kickoff time for the game is 3 p.m.
To purchase the specially-priced tickets, simply click HERE and, when prompted, enter the Special Offer Code: firstresponders.
Step-by-step instructions:
1) Go to: http://bit.ly/UMFRDay
2) Click "Find Tickets"
3) Under "Special Offer Code," type: firstresponders and click "Verify"
4) Under "Create an Account" (right of screen), type your email address
5) Follow the instructions to create your account
6) Enter the number of tickets you would like
7) Confirm Will Call as the ticket delivery method (You can print your tickets from home or pick them up at the game)
8) Enter your billing information and click "Submit Order"
Please call 305-284-2263 or email firstname.lastname@example.com if you need any assistance.