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On the August 5, 2014 primary ballot, you will see "Ballot Proposal 14-1, a referendum on public act 80 of 2014 which allocates use tax revenue for various local purposes."
The Michigan Legislature voted to phase out or eliminate the personal property tax (PPT) on certain business equipment and to replace the lost PPT revenue to local governments, school districts, libraries and other entities by allocating part of the existing use tax to those entities. The Michigan Constitution requires a vote of the citizens to enact changes to the use tax, so the Michigan Legislature voted to place this proposal on the ballot.
Frequently Asked Questions About Ballot Proposal 14-1
Would this proposal raise taxes?
No. This referendum is not a tax increase.
How does this proposal protect local communities?
This proposal creates a stable funding stream for communities in Michigan to pay for police, fire, ambulance, jails, schools, roads, libraries, and other community services. 100 percent of the funding for community services will be returned directly to Michigan communities for these community services. This dedicated funding for community services is no longer subject to the uncertainty and instability of annual legislative appropriations or politics in Lansing.
Does this proposal amend the constitution?
No. This is not a constitutional amendment. The state constitution requires that this bold effort to reduce taxes by eliminating double taxation on Michigan businesses and stabilizing local funding be approved by a vote of the people—or else the tax cut will be repealed.
How will this proposal affect small business?
The proposal provides an immediate tax cut for small businesses. Small businesses stopped paying the double tax on personal property effective January 2014. If the proposal fails, small businesses would immediately go back to paying the double tax on equipment that businesses in many others states don't have to pay.
How will this proposal affect manufacturing?
The proposal establishes a statewide Essential Services Assessment that is only paid for by manufacturers that receive a Personal Property Tax (PPT) reduction. Large and small manufacturing businesses will see the PPT phased out over time, beginning in 2016.
How is this funded?
It is paid for by eliminating special corporate tax breaks the Legislature had already voted to end, and by establishing a statewide Essential Services Assessment paid only by manufacturers receiving a personal property tax reduction. This proposal does not raise taxes for anybody.


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ED Magedson – Founder
Ripoff Report
Professional Credit ServicesSpringfield, Oregon USA
Professional Credit Services wierd, wrong, statute of limitations Springfield Oregon
Does your business have a bad reputation?
Fix it the right way.
Corporate Advocacy Program™
Today (December 10, 2013) I recieved a bill from Professional Credit Service. It is over a city owned municiple (water) bill. The bill is from 2005, and they say the last payment is from 02/07/2007.
I don't believe (though it's been a long time) that I have any unpaid bills from that time period. And even if I did, it's past the Oregon Statue of Limitations (right?).
It's not a lot of money, but at this point I am on SSI, and my husband is disabled with NO income. We don't have money for this now.
I just find this very, very odd because we never ran from any debt, and were sure we had paid all debts off.
Thanks, Peg
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Watch Sakura Trick
You are viewing Episode list with English Subbed. Navigate the episode to watch the video..
Total of Episodes: 12
Best friends Haruka and Yuu have just entered their first year at Misato West High School, a facility scheduled to be shut down in three years. The duo have been inseparable since middle school, but moving to a new school means making new friends. So together, the pair decides they'll share something special that they won't do with the other girls: they'll share a passionate kiss. Now, the two, along with new companions Kotone, Shizuku, Kaede and Yuku, begin their high school days together, having plenty of fun - and sharing plenty of intimate kisses - along the way.
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Conway Police Searching for Murder Suspect
CONWAY, AR -- The search for a capital murder suspect lead police officers to a Conway hotel early this morning.
Police were looking for 30-year-old Steven Swanigan for the murder of Garland County Woman April 30th.
According to the police, Swanigan ran from the Economy Inn on East Oak Street and got away by escaping down a creek bed.
Sean Cannady of the Conway Police Department says his escape has a lot of people worried.
"Definitely a lot of people showing concern because of toad suck...worried that he may show up down there again. I find it highly unlikely that he would go to such an area but we have several extra officers on patrol," Cannady said.
Garland County deputies say Swanigan shot three people Wednesday -- including a 20-month-old infant.
The baby survived and another victim sustained only minor injuries. A 26-year-old woman died from her injuries.
Anyone with information of Swanigan's whereabouts is asked to call law enforcement.
More Stories
Saline County Sheriff Deputies are looking for a murder suspect after…
Sunday a group of pastors react to the rising number of homicides in…
Storm damages businesses in Pottsville.


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It was registered by On behalf of mjradalegal.com OWNER , who can be reached at . The site is owned by c/o whoisproxy.com Ltd.. Registration details show that it was registered on 07 Jan 2016 through Google and will expire on 07 Jan 2017.


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Home › Forums › Gear Forums › Gear (General) › Brainstorm: Tyvek + Never Wet?
Aug 19, 2013 at 10:37 am #1306697
So I don't live in the USA and can't buy that new-ish Never Wet super waterproof double spray stuff. Tyvek is hard to get a hold of where I live too. But ever since the Never Wet stuff came out, one of the first things I thought of doing if I had it was to make a flat tarp with Tyvek, and then spray the heck out of it with NW.
Anyone done this yet? Or something similar? Or is this where someone (probably Anna) links to a thread and makes me look foolish…
… but HA! I already did a quick search and read all of this thread:
No tarp test there.
It just seems that because Tyvek is very water resistant and fairly cheap, that add this spray and it would be really good for things like tarps. Though I hear that it rubs off easy, but a tarp does not get that much abrasion. Maybe someone has a TT Sublite they could spray with it?
I want to read about more experiments and see more nerdy pictures people!
Edit: typos :/Aug 19, 2013 at 10:41 am #2016582
Link .BPL Member
That's funny Cesar,thanks for making me laugh :)Aug 19, 2013 at 11:07 am #2016586Aug 19, 2013 at 11:18 am #2016589
Link .BPL Member
I like it :)Aug 20, 2013 at 10:01 am #2016908
steven franchukMember
Tyvek 1443 has a hydrostatic head of 7622mm while Tyvek 1460 is 1270mm. That is enough to stop most rain.
Tyvek is made from polyethylene which is naturally hydrophobic. Neverwet is Superhyrophobic and probably will not change the hydrostatic head like all other DWR treatments.
Adding neverwet to tyvek will probably not make much of a difference. It will however add weight.Aug 20, 2013 at 11:14 am #2016936
Henry SBPL Member
My take is that anything you apply to Tyvek will reduce its breathability and if you do that then you've destroyed its best quality. I agree that Tyvek 1443R–the material we use in the Sublite–is remarkably water resistant. However, it does absorb some water and takes much longer to dry out than a coated fabric. For that reason you would want to think twice about using it in wet environment, at least if you intend to carry it.
-HAug 21, 2013 at 4:14 am #2017216
Yeah, I can see why one would not want to spray a Sublite considering the issue of breath-ability–thanks Henry. A tarp on the other hand, I would still be interested in seeing if this would be an effective thing to do. While Tyvek is very water resistant, NW could in theory make it waterproof and unable to absorb any water. And cheap to boot.
Just a brainstorm I had. I am surprised there seems to be not as much experimentation with NW now that it has been on the market for some time.
You must be logged in to reply to this topic.


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From the Editors
The Spring issue of the Arab Studies Journal is out! Click here.
Don't miss Tadween Publishing's latest blog entries at Al-Diwan. Click here.
Want to find out about new books? Visit our expanding NEWTON page. Click here.
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The New York Times says Jadaliyya "Brings New Life to Arab Studies." Read about it by clicking here.
Jadaliyya was featured in the Chronicle of Higher Education. Click here for the story.
Ahram Online and Nada Hussein Rashwan
Thousands Bid Farewell to Fallen Religious Cleric Killed in Tahrir Square
A funeral march for Emad Effat, a prominent Azhar cleric shown on video dying of gunshot wound sustained during attack by military police on the Cabinet protest, buries a new martyr. The funeral procession for Emad Effat, member of the Dar Al-Ifta religious authority, who died on Friday of a gunshot wound he sustained when military police violently dispersed a sit-in at the Cabinet headquarters, is currently on its way to the cemetary in Sayida Aisha ...Keep Reading »
Ahram Online is the English-language news web site published by Al-Ahram Establishment, Egypt's largest news organization, and the publisher of the Middle East's oldest newspaper, the daily Al-Ahram, in publication since 1875. Ahram Online was launched 26 November 2010.
Nada Hussein Rashwan writes for Ahram Online.


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The ski and snowboard world is a tight-knit community. When someone is badly injured or loses their life on the slopes, chances are you have shared a lift line with them, have met them at a bar, know them personally or are related to them.
Deaths at the snow in beach-obsessed Australia hits deep - and there have been a few already this season. A season that has been heralded for big powder storms and some of the best conditions in over a decade - conditions few of us are used to so accidents are bound to happen.
Excitement has been contagious and a fervor to be the first to get the most of each storm has infected already over-excited skiers and boarders who have attempted terrain outside of their skill level, ducked under closed ropes or hit the side and back country without appropriate equipment or knowledge.
Skier Mike Grace and snowboarder Nick Bennett, both from Sydney, were lucky to survive when they triggered an in-resort avalanche at Thredbo in late June this year, after ducking under closed ropes into 'Hipcheck', a run that took the life of a young male skier in 1998. Grace was buried under metres of snow for over an hour and only survived thanks to a freak air pocket and the skills of Thredbo Ski Patrol.
But avalanches don't happen in Australia, right? Wrong. They do and they occur regularly in the backcountry, especially after large dumps of snow. A 22-year-old-skier died in an avalanche triggered by a fractured cornice at Blue Lake in the Snowy region in 2008.
Social media has been filled with skiers and boarders snapping pics of slides they have triggered in places they shouldn't be this season. But there's nothing cool about setting off a slide, nothing, unless you are deliberately cutting a slope in an effort to reduce avalanche risk.
Even those who have the experience, equipment and knowledge have found themselves, sadly, in trouble. Experienced backcountry boarders Martin Buckland and Daniel Kerr died in a backcountry avalanche on Mount Bogong not far from their camp in mid-July.
Heavy snow - which June and July had lots of - can kill in insidious ways and you don't have to be on skis or on a snowboard. The death of a child hits to the very core and left a family devastated at Mount Buller early in the season. A mammoth snow fall turned roof tops into ticking time snow bombs that fell upon seven-year-old Haadi Akhtar who was playing nearby. There are no words.
In Thredbo, more recently, we heard the chopper blades before we saw them, the ominous sound of whirring air that signals the change in someone's life circumstance. Helicopters only land in New South Wales ski fields for one reason - to rescue.
I knew the chopper would be for the out-of-control snowboarder without a helmet that had run into a tree a mere ninety minutes prior, attended to by an off-duty patroller who was part of our skiing crew. She held his hand while he regained consciousness and struggled to remember his name, as ski patrol made their way to his aid.
Witnesses said he was out-of-control, out-of-his-depth, without a helmet, and his mates who were better boarders than him, had naturally ridden ahead, unaware of what was left behind. There are no winners in this story (or any of these stories), just devastated mates worried about the state of their buddy as he was intubated and airlifted to Canberra hospital. A snow trip gone horribly wrong.
It begs the question, why aren't helmets mandatory and what of the Alpine Responsibility Code? How many of the ten parts of the code do you honestly know or will stick to, including 'taking lessons from professional instructors to learn or progress', 'keep off closed trails', 'always stay in control' and not being under the influence of alcohol on a mountain that sells it come lunch time.
Surely both the code and basic avalanche knowledge should be taught in ski school, maybe even tested in order to gain lift access and definitely clearly signed throughout the mountains of Australia. Should we go as far as gates to the backcountry that are only open when you have a detected transceiver and no helmet no chairlift ride?
New Zealand are more used to avalanches and have thankfully been luckier this year when it comes to deaths at the ski fields, but only due to the lack of snow. This may all be about to change as snow storms this past week have heralded the final and late arrival of winter. Treble Cone received over 1.6 metres in the past seven days. That's a lot of snow.
So it is time to be extra alert across the ditch. The avalanche centre of New Zealand (Australia doesn't have one but should for education purposes alone) lists the Queenstown region as on a red high avalanche alert.
Yet this didn't stop more social media snaps of people hitting the unpatrolled out of bounds back bowls of Coronet Peak without avalanche gear. The same slopes that took the life of a thirty-year-old man in 2009.
When will we learn, or more importantly when will we be taught?
Do you think the Alpine Responsibility Code should be mandatory teaching in ski school? Have you been caught in avalanche conditions in Australia and survived a slide?
We are so excited about our #misssnowitall Instagram competition this year and with a trip to Japan up for grabs who wouldn't be? Did your instagram make our gallery this week?
Thanks to the Japan experts at Liquid Snow Tours and Hakuba Hotel Group we have a trip for two to Hakuba in Japan flying direct with Jetstar from Sydney, Brisbane or Melbourne with seven nights at the conveniently located Hakuba Springs Hotel, daily breakfast, five of nine day multi-resort lift passes for the Hakuba Valley, welcome drinks, transfers, in resort assistance and concierge service. Now that's how you do Hakuba in style.
To enter just tag your winter inspired Instagrams with #misssnowitall.
We will choose five finalists each week for our gallery above, and come September, our guest judge will choose our finalists from the gallery and you get to judge the ultimate winner of this fantastic week in Japan. Click here for full terms and conditions.
Follow Miss Snow It All on Facebook, Twitter and Instagram.
Email Miss Snow It All firstname.lastname@example.com


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The Bullitt County Retired Teachers Association delivered school supplies to principal Sheri Hamilton of Nichols Elementary School.
Carolyn Dennison, president of the BCRTA, and Janet Richardson, chairman of the community services committee of BCRTA, made the presentation of items.
SHEPHERDSVILLE - Work is underway to restore a former church in hopes of restoring broken lives.
The Apostolic Church of Restoration has opened at 233 Fifth Avenue in Shepherdsville, a former day care facility that began originally as a church.
Pastor David Mackowiak and church administrator Roy L. Darst are still in the process of renovating the facility, but they are ready to help community members now.
CLERMONT – Southern Living Magazine has named Bernheim Arboretum and Research Forest among the South's 10 best places to enjoy fall color ( http://www.southernliving.com/travel/souths-best-fall-colors/bernheim-aboretum-research-forest )and October is the perfect time to experience all of the forest's beauty while enjoying some of Bernheim's great programs and events.
Thanks to contributions collected by volunteer fire departments in the county, the WHAS Crusade for Children was able to give back to the Bullitt County community.
Crusade director Dawn Lee presented a $12,000 check to the Bullitt County CASA program.
The funds will be used to operate the program, which provides assistance to help juveniles who are in the justice system for reasons that they have no control over.
(StatePoint) With classes, sports, homework and other activities, weekdays are action packed for kids. Unfortunately, some students deal with an unwelcome addition to their daily routine -- bullying. An estimated 13 million students are bullied annually, according to government statistics.
(StatePoint) Halloween trails only behind Christmas when it comes to spending on decorations. Americans spent an estimated $6.9 billion on Halloween in 2013, according to the National Retail Federation.
SHEPHERDSVILLE - The Shepherdsville Police Department showed that their commander is a true grinder.
Col. Doug Puckett visited with local citizens during a "Coffee with the Chief" event at Cedar Grove Coffee House.
For one hour patrons received a free cup of coffee along with an opportunity to discuss issues of their choosing with Puckett or one of the other department members in attendance.
The topics ranged from specific issues within neighborhoods to overall city traffic situations.
LOUISVILLE - Bullitt County author Amy McCorkle will make a special appearance at an upcoming writer's convention in Louisville.
Imaginarium will take place Sept. 19-21 at the Crowne Plaza Hotel in Louisville. The event is a creative writing convention.
McCorkle will be featured as a guest speaker during the premier of her film, "Letters to Daniel," based on her book of the same title. The event will include a Q&A session with McCorkle, who will also sign copies of the book.
Parents can learn everything about their child's breakfast and lunch at school thanks to the new Nutrislice link available at www.bullittschools.org.
On the website, look for School Meal Menus in Nutrislice on the For Parents, For Staff and BCPS Community pages.
District School Food Services Manager Angela Voyles said Program Assistant Becky Willoughby invested quite a bit of time downloading information.
"There is a lot of information for the public thanks to Becky's efforts," she said.
Mount Washington Quilting Bees members Carol Heil, Diane Kisner, Carol Larkin, Beverly Gradisek, Pat Glass and Linda Gentry showed off their Kentucky State Fair winning entries.
(Not pictured are: Tedi Nunn, Kathy Sheehan and Carol Portman, Lee Hartnett.)
Kisner won second place in the two person quilt category and a first place ribbon with her granddaughter Tedi Nunn for a quilt made by a group.
Larkin won honorable mention for unfinished quilt top and first place for the two person quilt.
CLERMONT - Residents and businesses in the Clermont area consider themselves members of a full-time community.
The U.S. Postal Service, however, doesn't seem to agree.
As of Aug. 25, the Clermont Post Office officially changed to part-time open hours for customers, from noon to 4 p.m. weekdays and 8-10 a.m. Saturdays.
The change was part of a two-year plan implemented by USPS in 2012 to keep smaller community post offices and zip codes in place.
CEDAR GROVE - At the conclusion of Saturday's Schmid Funeral Home Bluegrass Invitational Golf Tournament at Heritage Hill Golf Course, the Bullitt East Lady Charger team, as well as the team from Presentation Academy, took the Ice Bucket Challenge to Support ALS.
With a little help from the team from Notre Dame Academy, there was plenty of ice water to go around which wasn't too bad on a hot and humid day. The Lady Charger team sent out a challenge to the Bullitt East boys' golf team to support ALS research.
The following youngsters were honored at the Bullitt County 4-H Fair:
*Jamisen McCrary -- red ribbon in junior leather arts and crafts class; and a red ribbon for wood science made from kit
*Lilly Mooney -- red ribbon in junior scrapbooking; red ribbon in junior paper crafts; red ribbon in junior color drawing; white ribbon in junior black and white drawing; white ribbon in needlework items with small amount of embroidery; white ribbon in horticulture black and white photograph; and blue ribbon in let's learn to sew/Unit 1/non-clothing option
FERN CREEK--Metro Louisville Mayor Greg Fischer returned to his roots recently as he was a guest speaker at the Fern Creek Community Association and Chamber of Commerce. The native of the Fern Creek community spoke about some of the accomplishments during his tenure and his plans for the future. The luncheon was sponsored by The Pioneer News, which is a member of the organization.
SHEPHERDSVILLE--Louisville artist Dylana Music brought her musical talents to Shepherdsville last weekend during the first Color Your City event at the park. There were various activities to bring awareness to the many types of art.
HILLVIEW - The father-son bowling team from Bullitt County didn't bring home the international trophy, but they did receive great memories and a little bit of college funding.
Zoneton Middle School seventh grader Eric S. Dezarn and his father, Eric V. "Bam Bam" Dezarn, paced 28th out of 38 teams in the International Family Tournament presented by the Bowling Proprietors' Association of America.
The pair earned their way into the international championship by winning the state qualifier at Fern Valley Strike and Spare in Louisville.
LOUISVILLE –The Kentucky State Fair offers discount admission on select days of the Fair, including Military Monday, Humana Seniors' Discount Day and Early Bird Special day.
PIONEER VILLAGE - Maryville Elementary students plan to have green thumbs next semester in the school's new community garden.
Maryville received a Lowe's Community Toolbox Grant in the amount of $3,600 to purchase the garden, first planted in April by administrators, students and families.
The earliest opening day in Bullitt County Public Schools history has arrived.
Students experienced a beautiful summer day as they arrived at school on Wednesday, Aug. 6.
The Pioneer News will visit each BCPS school location during opening week. Continue to check the multimedia section of www.pioneernews.net for photos.
SHEPHERDSVILLE - They sat at Bullitt Lick Middle School to learn how to sit better.
Thirty local girls, age 11-13, participated in two Safe Sitter educational programs, a one-day event designed to share safe and nurturing child care techniques, behavior management skills and responses to emergency situations.
The program was hosted by Bullitt County Health Department educator Liz McGuire and Bullitt Lick Youth Services Center coordinator Tara Davis.
Copyright © 2017
The Pioneer News Online is your source for local news, sports, events and information in Bullitt County and Shepherdsville, KY, and the surrounding area.


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Dash in the Desert!
Leave your prediction of "Who's Gonna Win" in the comment section below and if you guess correctly, you will have a chance to win a large die cast car autographed by Michael Waltrip AND a $25 Best Western Travel Card®! Make your prediction now.
*Entries must be in before the start of the race on 11/14, and winner will be announced on 11/15.
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Hill Street Blues
253 Fans
Hill Street Blues is a combination of drama and comedy. Set in the ghetto area of a large, unnamed East Coast US city. Each episode is a day in the life of the precinct from early morning roll-call to a late-night rehash of the day's events, usually by Captain Frank Furillo, head of the unit, and Joyce Davenport, his secret lover and later wife.
Played by:
Character Bio
[No description found for this character]
Episode Screenshots
Sgt. Lucy Bates Quotes
|Season 7 / Episode 12: - A Wasted Weekend
Sgt. Howard Hunter: [during Roll Call] Sgt. Stanis Jablonski, Metro Police, retired, is going hunting with several of our colleagues.
Sgt. Lucy Bates: They're going out to kill Bambi. [laughter and murmering from the other cops] They're going out to slaughter poor defenceless creatures.
Officer J.D. LaRue: Hey, if you can eat it, you can kill it.
Sgt. Lucy Bates: Wanna keep your personal life to yourself, LaRue?
|Season 4 / Episode 5: - Doris in Wonderland
Dr. Stuart: So, officer Bates... you come here often? [Lucy's look indicates she's in no mood for flirting] What happened?
Sgt. Lucy Bates: I knocked this kid out with my ribs.
Sgt. Lucy Bates Photos
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Drawing On Science
A pseudo-science consists of a series of hypotheses said to be true, but actually lacks any supportable evidence or observations. Astrology is an example of a pseudo-science. It can be traced back some 3,000 years when the ancient Chaldeans and Assyrians, among others, began looking toward the patterns of stars. They believed that such patterns influenced the lives of humans. The belief that patterns found in nature influence human behavior most likely began when man first became aware of the world around him. It was also accepted that the stars and other celestial bodies have an effect on a person's life and behavior. Read the words in the 1941 movie, "The Wolfman": Even a man who is pure in heart, and says his prayers by night, may become a wolf when the wolfbane blooms and the autumn moon is bright. Although written for the movie the words are based on ancient beliefs; things in nature control a man's personality.
If one event follows another then, surely, the first one influenced the second. For example, if a comet was spotted at the time of a person's birth, then that person must be destined to be famous. This was the case with Sitting Bull, born around 1831 with the appearance of Halley's Comet. Sitting Bull was one of the masterminds of Custer's defeat. Was it the comet that accounted for his success? Or was it just a series of events throughout his life that led to the moment of the Little Big Horn battle? Now if the series of events were due to the comet also, then that must have been one heck of a rock! By the way Mark Twain's death in 1910 was accompanied by the same comet.
Now let's cut to the chase and see why astrology is a business and a joke rather than a true science.
Ancient observers tracked the paths of the planets each night. They discovered that the stars seemed to remain in a given zone in space. They called this zone the zodiac. They determined that groups of stars formed patterns, which were called constellations. They also found that the planets, sun and moon have various positions within a constellation during the year. A horoscope consists of a chart showing the positions of the celestial bodies at a given time. Their point in space is related to the constellations at the moment one's horoscope is being determined. Now here's the problem: the original astrologers fixed the stars to represent twelve zodiacal constellations; each constellation having a sign and a given personality trait. In 1867 BCE the twelve signs were measured from a point where the sun crossed the celestial equator on March 21, the spring equinox. This point was the constellation Aries. So, a person born between March 21 and April 20 was born under the sign of Aries with a given personality and future. The other signs are Taurus, Gemini, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius and Pisces.
Each sign is associated with, among other things, an element, a house and a planet. An astrologist would tell me I was born under the sign of Taurus, April 24. My element is Earth and my planet is Venus. And, because of this, I was destined to have a specific personality and future; the same personality and future along with millions of others born on April 24; before and after as well!
But astrologers hadn't counted on precession (=the angle of the earth's axis changes in space so that the north and south poles move in a small circle). Precession was discovered by Hipparchus around 130 BCE. As a result the apparent positions of the stars are slowly changing. One precession circuit occurs every 26,000 years. Because of precession the first point of Aries relative to the constellations has shifted and is shifting in space. The original signs no longer correspond to their appropriate constellations today! You see the sign for Aries is now in Pisces. As for me, I was born under the sign of Aries not Taurus. Shocking! All my past horoscopes have steered me in the wrong direction. Beam me up Scotty!
How did the astrologers repair such a contradiction based on scientific fact? Easy. They said that the signs were more important than the constellations. So they set the signs at 30o intervals measured from the spring equinox of March 21. But, by Zeus, the sun, today, is still in the constellation of Pisces most of this time. Ridiculous, isn't it. You can't mold science facts to fit your supernatural beliefs. To make matters worse for astrology, the stars are in constant motion. As a result the constellations, themselves, are changing patterns. Astrologers can solve this problem too. Come up with new constellation patterns and characters. Astrology, you see, is one step removed from the realities of science. Yet millions of people read their daily horoscopes looking for the way to success in a number of things including marriage, making money and avoiding problems.
Here's another thought: the planets Uranus, Neptune and Pluto (poor dwarf Pluto) were discovered in 1781, 1846 and 1930 respectively. This means that all of the horoscopes before 1930 had to be incorrect! Besides why didn't pre-1930's astrologers know that there must be more planets somewhere out there. Couldn't they sense their influences? Even today astrologers are in conflict regarding the right way to make and read horoscopes.
Not convinced? Here's the simplest challenge of all: have a friend go to the page in this paper (or any paper) where the horoscope appears. Have him/her choose any horoscope at random and read it to you. Then read another and then a third. Which one would you choose as your horoscope? If that doesn't convince you, I have a job for you: go out and make sense of the new traffic patterns in the Rockaways. Maybe the patterns mean something written in the stars...something only an astrologer knows. Questions/comments? E-mail Steve: email@example.com


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Research Topics
Genomes and Genes
Gene Symbol: FANCB
Description: Fanconi anemia complementation group B
Alias: FA2, FAAP90, FAAP95, FAB, FACB, Fanconi anemia group B protein, Fanconi anemia-associated polypeptide of 95 kDa
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications756 found, 100 shown here
- Volume sensitive hypertension and the digoxin-like factor. Reversal by a Fab directed against digoxin in DOCA-salt hypertensive ratsH Krep
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Am J Hypertens 8:921-7. 1995..To examine that possibility, we assessed the depressor responses to Digibind, an antibody Fab directed against digoxin, in a volume-dependent model--DOCA-salt-induced hypertension in rats...
- [Use of abciximab during coronary angioplasty]F Philippe
Service de cardiologie, , Paris
Arch Mal Coeur Vaiss 90:1645-50. 1997..Abciximab is a Fab fragment of the chimeric monoclonal antibody (c7E3) interfering with the glycoprotein receptor...
- Direct determination of E2020 enantiomers in plasma by liquid chromatography-mass spectrometry and column-switching techniquesK Matsui
Department of Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co, Ltd, Ibarak, Japan
J Chromatogr A 694:209-18. 1995..This system employs two avidin columns and fast atom bombardment (FAB)-MS. A plasma sample was injected directly into an avidin trapping column (10 mm x 4.0 mm I.D.)...
- Enzyme amplification as detection tool in continuous-flow systems. I. Development of an enzyme-amplified biochemical detection system coupled on-line to flow-injection analysisM R van Bommel
Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
J Chromatogr A 855:383-96. 1999..Biotin possesses a high affinity to both streptavidin and anti-biotin Fab fragments, which are both tested...
- Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administrationJ Mordenti
Department of Experimental Therapeutics, Genentech, Inc, Souty San Francisco, California 94080, USA
Toxicol Pathol 27:536-44. 1999..humanized rhuMAb HER2 antibody (148 kD) and of 125I-labeled humanized rhuMAb vascular endothelial growth factor Fab antibody (48.3 kD) following bilateral bolus intravitreal injection on day 0 (5 animals/group)...
- The 1.85 A resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: revisiting the solvation of antigen combining sitesK Faelber
Forschungsgruppe Kristallographie, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Str 10, 13092 Berlin, Germany
J Mol Biol 313:83-97. 2001..We report the crystal structure of the complex between tissue factor (TF) and the humanized Fab fragment D3h44 at a resolution of 1.85 A together with the structure of uncomplexed D3h44 at the same resolution...
- [Good response to ganciclovir in a patient of cytomegalovirus (CMV) interstitial pneumonitis and gastric ulcer following allogeneic bone marrow transplantation for acute lymphoblastic leukemia]S Mizuno
Bone Marrow Transplantation Group of Miyazaki Prefectural Hospital
Kansenshogaku Zasshi 69:213-7. 1995..initially treated with vincristine, prednisolone and L-asparaginase for acute lymphoblastic leukemia (ALL, L1 by FAB classification) in 1988 and entered into complete remission...
- Orientation of cholera toxin bound to model membranesD Cabral Lilly
Biophysics Department, Boston University School of Medicine, Massachusetts 02118
Biophys J 66:935-41. 1994..The A-subunit may also extend into the pore of the pentamer. In addition, Fab fragments from a monoclonal antibody to the A-subunit were mixed with the toxin prior to binding to GM1...
- Role of high-performance liquid chromatographic protein analysis in developing fermentation processes for recombinant human growth hormone, relaxin, antibody fragments and lymphotoxinF S Jacobson
Department of Fermentation and Cell Culture Process Development, Genentech, Inc, South San Francisco, CA 94080, USA
J Chromatogr A 763:31-48. 1997..coli, allowing the separation and quantitation of the desired Fab' and Fab'2, as well as the unwanted products of glutathione addition and translational read-through...
- Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator geneA Minelli
Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
Cancer Genet Cytogenet 124:147-51. 2001..A trisomy 8 was also present in one of them, who later developed an acute myeloid leukemia (AML) of the M0 FAB-type and died, whereas the other died with no evolution into AML...
- Effects of digoxin-specific antibody Fab fragment (Digibind) on blood pressure and renal water-sodium metabolism in 5/6 reduced renal mass hypertensive ratsJ Kaide
Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
Am J Hypertens 12:611-9. 1999..renal mass hypertensive rats (RRM), we studied the effects of acute administration of digoxin-specific antibody Fab fragment (Digibind) in the early phase and the chronic phase of hypertension in RRM...
- Reversal of sodium pump inhibitor induced vascular smooth muscle contraction with digibind. Stoichiometry and its implicationsH H Krep
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Am J Hypertens 9:39-46. 1996..Our second goal was to examine the ability of Digibind, a Fab fragment of antisera directed against digoxin, to reverse VSM contraction induced by both agents...
- Ultrastructural abnormalities of bone marrow erythroblasts in refractory anemiaT Sakura
Third Department of Internal Medicine, Gunma University School of Medicine, Japan
Ultrastruct Pathol 22:173-80. 1998Ultrastructural abnormalities of erythroblasts in 30 patients with refractory anemia (RA) according to FAB classification were studied...
- Fab antibody fragments: some applications in clinical toxicologyRobert J Flanagan
Medical Toxicology Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
Drug Saf 27:1115-33. 2004This review provides current information on the use of antigen-binding fragments (Fab) from cleaved antibodies to treat poisoning with digoxin and other potent, low formula mass poisons, such as colchicine and tricyclic antidepressants...
- Identification of unlawful food dyes by thin-layer chromatography-fast atom bombardment mass spectrometryH Oka
Aichi Prefectural Institute of Public Health, Nagoya, Japan
J Chromatogr A 674:301-7. 1994A thin-layer chromatographic-fast atom bombardment mass spectrometric (TLC-FAB-MS) method incorporating an analyte condensation technique was established for the identification of the 27 food dyes consisting the twelve dyes permitted for ..
- High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer modelT M Behr
Department of Nuclear Medicine, Georg August University, Gottingen, Germany
Cancer Res 59:2635-43. 1999..efficacy of RIT with the alpha emitter 213Bi/213Po, as compared to the beta emitter 90Y, linked to a monovalent Fab' fragment in a human colonic cancer xenograft model in nude mice...
- [Cytogenetic analysis on 1058 cases of acute nonlymphocytic leukemia]Y Xue
The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Suzhou, Jiangsu 215006 P.R. China. ublic1.sz.js.cn
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:247-50. 2001..may be found to have clonal chromosomal abnormalities which are predominantly specific chromosomal rearrangements correlated with specific FAB subtypes. Thus, karyotype is an important indicator for diagnosis and classification of ANLL.
- Radioimmunotherapy with 90Y-labeled monoclonal antibodies in a nude mouse ovarian cancer modelK Kairemo
Department of Clinical Chemistry, Helsinki University Central Hospital, Finland
Acta Oncol 32:801-5. 1993..We treated nude mice bearing human ovarian carcinoma xenografts with 90Y-labeled monoclonal antifibrin antibody Fab fragments administered intratumorally. The survival time vs...
- Chronic blockade of brain "ouabain" prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failureB S Huang
Hypertension Unit, University of Ottawa Heart Institute, ON, Canada
Can J Physiol Pharmacol 78:45-53. 2000..Animals were treated with 200 microg x day(-1) i.c.v. or i.v. Fab fragments (which bind brain "ouabain" with high affinity), or treated with 200 microg x day(-1) i.c.v...
- Diagnostic and prognostic relevance of the immunophenotype in acute myelocytic leukemiaV Callea
Divisione di Ematologia, Ospedali Riuniti, Reggio Calabria, Italy
Tumori 77:28-31. 1991..When the morphologic criteria of the FAB classification was compared with the normal myeloid and erythroid pathway of differentiation identified by MoAbs, a ..
- Clinical utility of radioimmunoscintigraphy of non-Hodgkin's lymphoma with radiolabelled LL2 monoclonal antibody, LymphoSCAN: preliminary resultsM Gasparini
Nuclear Medicine Department, National Cancer Institute, Milan, Italy
Tumori 81:173-8. 1995..The objective of this study was to evaluate the efficacy of an antilymphoma antibody in the Fab' fragment form, labelled with 99mTc, to detect malignant lesions...
- Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomationJose Maria Gutierrez
Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
Clin Pharmacokinet 42:721-41. 2003..are made of: (i) whole IgG molecules (150 kDa), (ii) F(ab')(2) immunoglobulin fragments (100 kDa) or (iii) Fab immunoglobulin fragments (50 kDa)...
- Characterization of carbohydrates using a combination of derivatization, high-performance liquid chromatography and mass spectrometryX Shen
Department of Chemistry, University of Manitoba, Winnipeg, Canada
J Chromatogr A 811:47-59. 1998..PMP- and PA-monosaccharides produced abundant ions by either fast atom bombardment (FAB), electrospray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)...
- An objective approach to antivenom therapy and assessment of first-aid measures in snake biteR D Theakston
Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine
Ann Trop Med Parasitol 91:857-65. 1997..with a monospecific as opposed to a polyspecific antivenom has been demonstrated, and new, smaller fragment, Fab antivenoms have been developed and are now under clinical assessment...
- Anti-immunoglobulin responses to IgG, F(ab')2, and Fab botulinum antitoxins in miceCarl N Mayers
Microbiology, Dstl Chemical and Biological Sciences, Porton Down, Salisbury, Wiltshire, UK
Immunopharmacol Immunotoxicol 25:397-408. 2003..To investigate the immunogenicity of different immunoglobulin fragments, whole IgG, F(ab')2 and Fab botulinum antitoxins were administered to mice by either the intravenous or intramuscular route...
- On-line solid-phase extraction liquid chromatography-continuous flow frit fast atom bombardment mass spectrometric and tandem mass spectrometric determination of hydrolysis products of nerve agents alkyl methylphosphonic acids by p-bromophenacyl derivatizM Katagi
Forensic Science Laboratory, Osaka Prefectural Police H.Q, Japan
J Chromatogr A 833:169-79. 1999..acid and pinacolyl methyl phosphonic acid was explored by using continuous flow frit fast atom bombardment (FAB) LC-MS and LC-MS-MS...
- [Indium III monoclonal antimyosin antibody scintigraphy for the detection of chronic myocardial infarction apart from the acute phase]C Adrie
Service de cardiologie, , Paris
Arch Mal Coeur Vaiss 88:1863-8. 1995b>Fab antimyosin scintigraphy has been shown to be sensitive and specific in detecting acute myocardial necrosis...
- Antibody immobilization to high-performance liquid chromatography supports. Characterization of maximum loading capacity for intact immunoglobulin G and Fab fragmentsW Clarke
Department of Chemistry, University of Nebraska, Lincoln 68588-0304, USA
J Chromatogr A 888:13-22. 2000This study examined various factors that affect the maximum amount of intact immunoglobulin G (IgG) or Fab fragments that can be covalently immobilized to silica and other HPLC-grade supports for use in immunoaffinity chromatography or ..
- Molecular analysis of simple variant translocations in acute promyelocytic leukemiaJ Borrow
Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, UK
Genes Chromosomes Cancer 9:234-43. 1994The primary cytogenetic abnormality in acute promyelocytic leukemia (APL; FAB M3) is a reciprocal translocation, t(15;17)(q22;q12), which serves to fuse the PML gene on chromosome 15 to the retinoic acid receptor alpha (RARA) gene on ..
- Kinetic analysis of the interaction between the monoclonal antibody A33 and its colonic epithelial antigen by the use of an optical biosensor. A comparison of immobilisation strategiesB Catimel
Ludwig Institute for Cancer Research. PO Royal Melbourne Hospital, Parkville, Victoria, Australia
J Chromatogr A 776:15-30. 1997The interaction between the humanised A33 monoclonal antibody and the corresponding F(ab)'2 or Fab' fragments with the colonic epithelial A33 antigen, purified by micropreparative HPLC from membrane extracts of the colonic carcinoma cell ..
- A new screening model for safety evaluation of superantigen-antibody recombinant fusion proteins (mAb Fab-SEA/E) using telemetric monitoring in conscious rabbitsNils Gunnar Ilback
Toxicology Division, National Food Administration, Uppsala, Sweden
J Pharmacol Toxicol Methods 48:31-9. 2002..bacterial staphylococcal enterotoxin A/E (SEA/E) have been combined in single hybrid constructs (mAb Fab-SEA/E)...
- Crotalidae polyvalent immune Fab (ovine) antivenom is effective in the neutralization of South American viperidae venoms in a murine modelWilliam H Richardson
Department of Emergency Medicine, Palmetto Richland Memorial Hospital, Palmetto Poison Center, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Ann Emerg Med 45:595-602. 2005Crotalidae polyvalent immune Fab (ovine) (CroFab; FabAV) is used in the treatment of symptomatic crotaline envenomations in North America...
- Quantitative analysis of methionine enkephalin and beta-endorphin in the pituitary by liquid secondary ion mass spectrometry and tandem mass spectrometryD M Desiderio
Department of Biochemistry, University of Tennessee, Memphis 38163, USA
J Chromatogr A 794:85-96. 1998..Liquid secondary ion MS (LSI-MS), also known as fast atom bombardment (FAB), is used to desorb and to ionize the peptide...
- P-glycoprotein and terminal transferase expression identify prognostic subsets within cytogenetic risk classes in acute myeloid leukemiaG Del Poeta
Cattedra e Divisione di Ematologia, Universita Tor Vergata, Ospedale S Eugenio, Roma, Italy
Leuk Res 23:451-65. 1999..5% and 24% of cases, respectively. There were strict correlations either between UIC2 negativity and FAB M3 or between TdT and FAB M0-M1 (P = 0.001 and < 0.0001, respectively)...
- [Evaluation of direct immunoperoxidase technique using F(ab')2 fractions of anti-cytomegalovirus human monoclonal antibody for enumeration of cytomegalovirus antigen-positive leukocytes]T Minematsu
Department of Microbiology, Miyazaki Medical College
Kansenshogaku Zasshi 68:1278-84. 1994..horseradish peroxidase (HRR)-labeled F(ab')2 fractions of C7 antibody were found to be superior to the equivalent Fab' fractions, because the former was much more stable than the latter...
- Digoxin and digoxin derivative induced arrhythmias: in vitro binding and in vivo abolition of arrhythmias by digoxin immune Fab (DIGIBAND)D Cambridge
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
Cardiovasc Res 26:906-11. 1992..compare the binding characteristics of a highly purified digoxin specific antigen binding fragment (digoxin immune Fab: DIGIBIND) with digoxin and with two commonly used derivatives of digoxin, beta methyl digoxin and beta acetyl ..
- Survival of Enterococcus faecalis in mouse peritoneal macrophagesC R Gentry-Weeks
Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
Infect Immun 67:2160-5. 1999..faecalis 418 and two isogenic mutants [cytolytic strain FA2-2(pAM714) and non-cytolytic strain FA2-2(pAM771)] was compared with that of Escherichia coli DH5alpha by infecting ..
- Design, synthesis, and evaluation of [188Re]organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levelsTomoya Uehara
Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Bioconjug Chem 18:190-8. 2007..We have reported that Fab fragments labeled with 3'-[131I]iodohippuryl Nepsilon-maleoyl-lysine (HML) showed markedly low renal radioactivity ..
- Minimally differentiated acute myeloid leukemia: a morphologic, cytochemical and ultrastructural studyS S Alurkar
Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
Tumori 78:185-9. 1992..specific antigen analysis were carried out in all these patients and they were classified as AML-MO, as per the FAB criteria. Morphologically these blasts resembled ALL-L2/AML-M1...
- Isolation and structure determination of the main related substances of teicoplanin, a glycopeptide antibioticA Cometti
Merrell Dow Research Institute, Centro Ricerche Lepetit, Gerenzano VA, Italy
Farmaco Sci 43:1005-18. 1988..M.R. spectra and homonuclear CO-SY 2D experiments, FAB-MS spectrometry, and GC-MS of the esters of the fatty acids obtained by hydrolysis...
- The chronic lymphocytic leukemia antigen (cCLLa) as immunotherapy target: assessment of LD50 and MTD of four ricin-based anti-cCLLa immunotoxins (ITs) in Balb/c miceG B Faguet
Department of Medicine, Medical College of Georgia, VA Medical Center, Augusta 30910, USA
Leuk Lymphoma 25:531-7. 1997..in Balb/c mice of four anti-cCLLa immunotoxins (ITs) derived from the intact monoclonal antibody (MoAb) or its Fab fraction, each conjugated to either ricin chain-A (RTA) or its deglycosylated derivative (dgA)...
- Studies on the red marrow dosimetry in radioimmunotherapy: an experimental investigation of factors influencing the radiation-induced myelotoxicity in therapy with beta-, Auger/conversion electron-, or alpha-emittersT M Behr
Department of Nuclear Medicine of the Georg August University of Göttingen, Germany
Clin Cancer Res 5:3031s-3043s. 1999..doses (MTDs) of several murine, chimeric, and humanized immunoconjugates as complete IgG or fragments (F(ab)2 and Fab), labeled with beta(-)-emitters (such as 131I or 90Y), Auger electron-emitters (such as 125I or (111)In), or alpha-..
- Preparation of recombinant human monoclonal antibody Fab fragments specific for Entamoeba histolyticaH Tachibana
Departments of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Clin Diagn Lab Immunol 6:383-7. 1999Genes coding for human antibody Fab fragments specific for Entamoeba histolytica were cloned and expressed in Escherichia coli. Lymphocytes were separated from the peripheral blood of a patient with an amebic liver abscess...
- Correlation of red marrow radiation dosimetry with myelotoxicity: empirical factors influencing the radiation-induced myelotoxicity of radiolabeled antibodies, fragments and peptides in pre-clinical and clinical settingsThomas M Behr
Department of Nuclear Medicine of the Philipps University of Marburg, Marburg Lahn, Germany
Cancer Biother Radiopharm 17:445-64. 2002..and doses (MTDs) of several murine, chimeric and humanized immunoconjugates as complete IgG or fragments (F(ab)(2), Fab), as well as peptides, labeled with beta(-)- (such as (131)I or (90)Y), Auger electron- (such as (125)I or (111)In),..
- Structural comparison of different antibodies interacting with parvovirus capsidsSusan Hafenstein
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
J Virol 83:5556-66. 2009..5 to 18 A. The crystal structure of one of the Fab molecules and the sequence of the variable domain for each of the Fab molecules have been determined...
- Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study InvestigatorsC W Hamm
Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany
N Engl J Med 340:1623-9. 1999..We investigated whether serum troponin T levels identify patients most likely to benefit from therapy with this drug...
- Renal metabolism of 3'-iodohippuryl N(epsilon)-maleoyl-L-lysine (HML)-conjugated Fab fragmentsY Fujioka
Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Bioconjug Chem 12:178-85. 2001..In mice, HML-conjugated Fab demonstrated low renal radioactivity levels from early postinjection times...
- Construction of human Fab (gamma1/kappa) library and identification of human monoclonal Fab possessing neutralizing potency against Japanese encephalitis virusMitsue Arakawa
Department of Infectious Diseases, Faculty of Medicine, Oita University, Japan
Microbiol Immunol 51:617-25. 2007A combinatorial human Fab library was constructed using RNAs from peripheral blood lymphocytes obtained from Japanese encephalitis virus hyper-immune volunteers on pComb3H phagemid vector. The size of the constructed Fab library was 3...
- Tryptic peptide mapping of sequence 299-585 of human serum albumin by high-performance liquid chromatography and fast atom bombardment mass spectrometryS Fisichella
Dipartimento di Scienze Chimiche, , Italy
J Chromatogr A 693:33-44. 1995..bromide fragment A) of human serum albumin (HSA) by chemical and enzymatic cleavages and combined use of HPLC and FAB-MS is described...
- c7E3 Fab inhibits low shear flow modulated platelet adhesion to endothelium and surface-absorbed fibrinogen by blocking platelet GP IIb/IIIa as well as endothelial vitronectin receptor--results from patients with acute myocardial infarction and healthy coA J Reininger
Anatomisches Institut, Technische Universitat Munchen, Germany
Thromb Haemost 83:217-23. 2000The c7E3 Fab reduces ischemic complications in patients undergoing high-risk coronary angioplasty or atherectomy...
- Optimizing bispecific antibody pretargeting for use in radioimmunotherapyRobert M Sharkey
Center for Molecular Medicine and Immunology, Belleville, New Jersey 07109, USA
Clin Cancer Res 9:3897S-913S. 2003....
- High expression of urokinase plasminogen activator receptor (UPA-R) in acute myeloid leukemia (AML) is associated with worse prognosisMichaela Graf
Medical Department III, Klinikum Grosshadern, University of Munich, Munich, Germany
Am J Hematol 79:26-35. 2005..Expression of UPA-R was heterogeneous in different FAB types, however, with the highest expression rates in monocytic subtypes (FAB M4/M5): 18%/19%/30% of UPA-R+ cases ..
- Radioimmunotherapy of colorectal carcinoma xenografts in nude mice with yttrium-90 A33 IgG and Tri-Fab (TFM)P Antoniw
Celltech Therapeutics Ltd, Slough, Berks, UK
Br J Cancer 74:513-24. 1996..1994) J. Clin. Oncol. 12, 1561-1571]. A33 and an A33 tri-fab fragment (TFM) were labelled with 90Y via a stable macrocyclic ligand for biodistribution and therapy studies in ..
- TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reactionL R Fraser
Anatomy and Human Biology Group, King s College, Strand, London, United Kingdom
Mol Reprod Dev 48:375-82. 1997..When epididymal spermatozoa were incubated in the presence of anti-TCP-11 IgG Fab fragments for a total of 120 min and assessed using chlortetracycline fluorescence, we observed a stimulation of ..
- Secondary leukemias induced by topoisomerase-targeted drugsC A Felix
Division of Oncology, Department of Pediatrics, Abramson Research Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1400:233-55. 1998..The mean latency period is about 2 years. While most cases are of French-American-British (FAB) M4 or FAB M5 morphology, other FAB AML subtypes, myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL)..
- Intradermal anti-loxosceles Fab fragments attenuate dermonecrotic arachnidismH F Gomez
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0305, USA
Acad Emerg Med 6:1195-202. 1999..The authors used a rabbit model of dermonecrotic arachnidism to address the therapeutic efficacy of intradermal (id) polyclonal anti-Loxosceles Fab fragments (alphaLoxd Fab) raised against Loxosceles deserta spider venom.
- Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleedingChristoph Kleinschnitz
Department of Neurology, University of Wurzburg, Wurzburg, Germany
Circulation 115:2323-30. 2007..In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice...
- Brain imaging agents: synthesis and characterization of (N-piperidinylethyl) hexamethyl diaminodithiolate oxo technetium(V) complexesL A Epps
Johns Hopkins Medical Institutions, Baltimore, MD 21205 2179
Int J Rad Appl Instrum A 38:661-4. 1987..99Tc(NEP-DADT) complexes were prepared and characterized by HPLC, TLC, fast-atom-bombardment mass spectrometry (FAB MS) and other analytical techniques...
- Experimental studies on the role of antibody fragments in cancer radio-immunotherapy: Influence of radiation dose and dose rate on toxicity and anti-tumor efficacyT M Behr
Department of Nuclear Medicine, Georg August University, Gottingen, Germany
Int J Cancer 77:787-95. 1998..The aim of our study was, therefore, to determine the therapeutic performance of (131)I-labeled Fab as compared to bivalent conjugates and to analyze factors that influence dose-limiting organ toxicity and anti-..
- FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemiaJ M Nørgaard
Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
Eur J Haematol 67:221-9. 2001In 145 adult patients diagnosed with non-M3 acute myeloid leukaemia (AML) the relevance of FAB-subtype and immunophenotype to in vitro cellular drug resistance towards the anthracyclines aclarubicin (Acla) and daunorubicin (Dau), and the ..
- Factors influencing survival in myelodysplastic syndromes in a Brazilian population: comparison of FAB and WHO classificationsIrene Lorand-Metze
Department of Internal Medicine, Hemocentro State University of Campinas, PO Box 6198, BR 13081 970, Campinas, SP, Brazil
Leuk Res 28:587-94. 2004..Our aim was to examine the predictive value of the WHO and the FAB classification compared to parameters of peripheral blood, bone marrow and IPSS...
- How protein recognizes ladder-like polycyclic ethers. Interactions between ciguatoxin (CTX3C) fragments and its specific antibody 10C9Mihoko Ui
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277 8562, Chiba, Japan
J Biol Chem 283:19440-7. 2008..Using the crystal structures of anti-ciguatoxin antibody 10C9 Fab in ligand-free form and in complexes with ABCD-ring (CTX3C-ABCD) and ABCDE-ring (CTX3C-ABCDE) fragments of the ..
- Antigenic determinant of trichosanthin peptide fragmentsY P Ke
Shanghai Institute of Cell Biology, China
Immunopharmacol Immunotoxicol 10:131-9. 1988..Studies using fluorescence quenching measurements by titrating anti-TCS Fab with TCS and fragment I and II showed that four epitopes were present in intact TCS and one each epitope in ..
- Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive ratsB S Huang
Hypertension Unit, University of Ottawa Canada Heart Institute, Ontario, Canada
Hypertension 28:1005-12. 1996..sodium diet and concomitant intracerebroventricular infusions via minipumps of the following compounds: antibody Fab fragments (200 micrograms/d), which bind ouabain and related steroids with high affinity; the angiotensin II (Ang ..
- Molecular characterization of mutants of the acetate regulatory gene facB of Aspergillus nidulansR B Todd
Department of Genetics, The University of Melbourne, Parkville, Victoria, 3052, Australia
Fungal Genet Biol 22:92-102. 1997The facB gene of Aspergillus nidulans encodes a DNA binding transcriptional activator required for growth on acetate as a sole carbon source...
- Acute myelocytic leukemia and chronic myelomonocytic leukemia simultaneously with resectable breast cancer: a report of two casesL Cavanna
1a Divisione Medica, Ospedale Civile, Piacenza, Italy
Tumori 78:356-8. 1992..2 patients who developed acute myelocytic leukemia (AML) type M2 and chronic myelomonocytic leukemia (CMML) of the FAB classification, respectively 2 months and 2 weeks after diagnosis of operable breast cancer...
- Chemical design of radiolabeled antibody fragments for low renal radioactivity levelsY Arano
Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Cancer Res 59:128-34. 1999..3'-[131I]Iodohippuryl N(epsilon)-maleoyl-L-lysine ([131I]HML) was conjugated with a thiolated Fab fragment because the glycyl-lysine sequence in HML is a substrate for a brush border enzyme and metaiodohippuric ..
- Complementary roles of antibody affinity and specificity for in vivo diagnostic cardiovascular targeting: how specific is antimyosin for irreversible myocardial damage?B A Khaw
Northeastern University, Center for Cardiovascular Targeting, Boston, Massachusetts 02115, USA
J Nucl Cardiol 6:316-23. 1999..To characterize the role of antibody affinity, we performed studies in dogs with acute coronary occlusion followed by reperfusion using 3 monoclonal antimyosin antibodies with different affinities...
- Immobilized antibody orientation analysis using secondary ion mass spectrometry and fluorescence imaging of affinity-generated patternsFang Liu
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, USA
Anal Chem 82:2947-58. 2010..side-by-side copatterning of protein A (antibody Fc domain affinity reagent) and fluorescein (antibody Fab domain hapten) was achieved photolithographically on commercial amine-reactive hydrogel polymer surfaces...
- Cloning and expression of human V-genes derived from phage display libraries as fully assembled human anti-TNF alpha monoclonal antibodiesS M Mahler
Department of Biotechnology, University of New South Wales, Kensington, Sydney, Australia
Immunotechnology 3:31-43. 1997..After selection, Fabs and scFvs may need to be expressed as complete antibodies in mammalian cells for further characterisation, or if effector functions are required...
- Repeated treatment with antibody-targeted superantigens strongly inhibits tumor growthA Rosendahl
Pharmacia and Upjohn, Lund Research Center, Sweden
Int J Cancer 76:274-83. 1998..a novel approach for cancer immunotherapy by genetically fusing the SAg staphylococcal enterotoxin A (SEA) to a Fab-fragment of a tumor-specific antibody...
- A comparative review of classification systems in myelodysplastic syndromes (MDS)John M Bennett
James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
Semin Oncol 32:S3-10. 2005..The French-American-British (FAB) classification scheme for MDS was described in 1982 and has become the reference standard for subsequent MDS ..
- Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatinationD Scott Wilbur
Department of Radiation Oncology, University of Washington, Seattle, Washington 98195, USA
Bioconjug Chem 18:1226-40. 2007..in vivo stability toward deastatination when (relatively) rapidly metabolized proteins, such as monoclonal antibody Fab' fragments, are labeled...
- Direct observation of adsorption-induced inactivation of antibody fragments surrounded by mixed-PEG layer on a gold surfaceKeitaro Yoshimoto
Graduate School of Pure and Applied Science, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8573, Japan
J Am Chem Soc 132:7982-9. 2010To examine the adsorption behavior of antibody fragments (Fab') directly immobilized on a gold surface through S-Au linkage, analyses by surface plasmon resonance (SPR), fluorometry, and atomic force microscopy (AFM) with an excellent ..
- Efficient production of an antibody Fab fragment using the baculovirus-insect cell systemTakanori Furuta
Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1 1 Rokkodai, Nada, Kobe 657 8501, Japan
J Biosci Bioeng 110:577-81. 2010The production of an Fab fragment of the catalytic antibody 6D9 in lepidopteran insect cells infected with a recombinant baculovirus that contained both the heavy chain (Hc) and light chain (Lc) genes of the Fab fragment was investigated...
- Application of ion chromatography to the semiconductor industry. I. Measurement of acidic airborne contaminants in cleanroomsS J Lue
Department of Chemical Engineering, Chang Gung University, Kwei-Shan, Taoyuan County, Taiwan
J Chromatogr A 804:273-8. 1998..measurement of various acidic airborne contaminants in class 1 cleanrooms of a semiconductor fabrication facility (Fab)...
- Mass spectrometric analysis of tetracycline antibiotics in foodsH Oka
Aichi Prefectural Institute of Public Health, Nagoya, Japan
J Chromatogr A 812:309-19. 1998..mass-analysed ion kinetic energy spectrometry (CAD MIKES), thin-layer chromatography (TLC)- fast atom bombardment (FAB) mass spectrometry (MS), particle beam (PB) liquid chromatography (LC)-MS, LC-fit FAB MS, thermospray (TSP) LC-MS, ..
- Construction of bacteriophage expressing mouse monoclonal Fab fragments directed against the human MN glycophorin blood group antigensM Czerwinski
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Transfusion 35:137-44. 1995..The construction of combinatorial immunoglobulin libraries displaying antibody Fab fragments on the surface of bacteriophage (Fab-phage) represents a novel approach for developing monoclonal ..
- Hemodynamic effects of the Fab fragment of digoxin antibody (digibind) in corticotropin (ACTH)-induced hypertensionM Li
Department of Medicine, St. George Hospital, Kogarah, New South Wales, Australia
Am J Hypertens 10:332-6. 1997To determine whether the immune Fab fragment of digoxin antibody (digibind) attenuates established corticotropin (ACTH) hypertension, rats were given ACTH sham control (0...
- Cytogenetic profile in de novo acute myeloid leukemia with FAB subtypes M0, M1, and M2: a study based on 652 cases analyzed with morphology, cytogenetics, and fluorescence in situ hybridizationMirjam Klaus
Department of Internal Medicine III, Laboratory for Leukemia Diagnostics, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Cancer Genet Cytogenet 155:47-56. 2004..To determine a pattern of cytogenetic abnormalities within the French-American-British (FAB) subtypes AML M0, M1, and M2, we analyzed 48 AML M0, 179 AML M1, and 425 AML M2 and compared cytogenetic data to a ..
- Production of a recombinant antibody fragment in whole insect larvaeElena Kovaleva
U S Army Edgewood Chemical Biological Center, AMSRD ECB RT BM, 5183 Blackhawk Road, Aberdeen Proving Ground, MD, 21010, USA
Mol Biotechnol 36:44-51. 2007..As a test model, we produced a recombinant mouse anti-botulinum antibody fragment (Fab) in Trichoplusia ni larvae...
- Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodiesFrancesco Latrofa
Department of Endocrinology, University Hospital of Pisa, Via Cisanello 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 93:591-6. 2008....
- Amperometric immunosensor for detection of celiac disease toxic gliadin based on Fab fragmentsHossam M Nassef
Nanobiotechnology and Bioanalysis Group, Department of Chemical Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain
Anal Chem 81:5299-307. 2009..on the development of an electrochemical gliadin immunosensor based on the spontaneous self-assembly of antigliadin Fab fragments (CDC5-Fab) on Au surfaces...
- Synthesis, characterization and biodistribution of the cationic technetium(II) 1,10-phenanthroline chelateK Schwochau
, , Germany
Int J Rad Appl Instrum A 43:1079-82. 1992..of pertechnetate with sodium borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry, magnetic susceptibility measurements, and i.r./vis/u.v. spectrophotometry...
- Alternative technologies to generate monoclonal antibodiesT Stigbrand
Department of Medical Biochemistry and Biophysics, University of Umea, Sweden
Acta Oncol 32:841-4. 1993..Different proteolytic procedures have been used for the fragmentation of intact antibodies to Fab2' and Fab fragments and recombinant DNA techniques have made it possible to obtain chimeric, humanized, Fv fragments and ..
- Labeling of ethambutol with 99mTc using a new reduction procedure. Pharmacokinetic study in the mouse and ratJ E Causse
Institut de Biologie, , Montpellier, France
Int J Rad Appl Instrum A 41:493-6. 1990..The complex was then analyzed by paper and cellulose F chromatography and by FAB mass spectrometry...
- Toward the production of bispecific antibody fragments for clinical applicationsP Carter
Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
J Hematother 4:463-70. 1995..three technologies appear suitable for the production of BsAb fragments for clinical applications: BsF(ab')2 assembled from Fab' fragments expressed in Escherichia coli, BsF(ab')2 assembled using leucine zippers, and diabodies.
- A pyoverdin from Pseudomonas sp. CFML 95-275R Sultana
, Germany
Z Naturforsch C 55:857-65. 2000..pyoverdin is identical with one obtained from Pseudomonas fluorescens BTP 7 for which a lactone structure had been deduced from the interpretation of a FAB spectrum. The elucidation of the correct structure of the pyoverdin is described.
- Separation and detection of 4-hexadecylaniline maltooligosaccharide derivatives with packed capillary liquid chromatography-frit fast atom bombardment-mass spectrometryL Johansson
Department of Medical Biochemistry, , Sweden
J Chromatogr A 712:149-54. 1995..The LC system is based on slurry-packed capillary columns. Frit fast atom bombardment (frit-FAB) is used as the LC-MS interface and ionisation technique and the column is connected to the frit via a 50 microns I...
- Lung cancer in acute myelomonocytic leukemia: a report of two casesR Marra
Istituto di Semeiotica Medica, , Roma, Italia
Tumori 74:553-4. 1988The authors describe two cases of acute nonlymphoblastic leukemia, FAB subtype M4, who developed a lung cancer while in complete remission of the leukemia. The possible interrelations between the two diseases are discussed.
- The synthesis of protective fragments of alpha-human atrial natriuretic polypeptide (alpha-hANP)M S Cai
Department of Organic Chemistry, Beijing Medical University
Sci Sin B 31:444-56. 1988..The sequence of amino acids of all the protective polypeptides is confirmed by FAB-MS.
- Purification and characterization of the MUC1 mucin-type glycoprotein, epitectin, from human urine: structures of the major oligosaccharide alditolsV P Bhavanandan
Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey 17033, USA
Glycoconj J 15:37-49. 1998..The O-linked saccharides of epitectin were fractionated by HPLC and analyzed by permethylation and FAB-MS...
- Reactive arthritis: the result of an anti-idiotypic immune response to a bacterial lipopolysaccharide antigen where the idiotype has the immunological appearance of a synovial antigenJ R Kennedy
West Bradenton, Florida, USA
Med Hypotheses 54:723-5. 2000..where a bacterial lipopolysaccharide (LPS) epitope is recognized by idiotypic (Id) T cell receptors and antibody Fab immune recognition surfaces (IRS) which have the immunologic appearance of an antigen on the synovial surface...
- Treatment of childhood acute myelogenous leukemia with allogeneic and autologous stem cell transplantation during the first remission: a report from the Kyushu-Yamaguchi Children's Cancer Study group in JapanA Matsuzaki
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pediatr Hematol Oncol 17:623-34. 2000A total of 64 newly diagnosed acute myelogenous leukemia patients (except FAB M3 and/or Down syndrome) under 18 years of age were consecutively enrolled into the study...
- In vivo evidence for a dependence on interleukin 15 for survival of natural killer cellsMegan A Cooper
Department of Internal Medicine, Division of Hematology Oncology, The James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
Blood 100:3633-8. 2002..Furthermore, mice with severe combined immunodeficiency treated with the Fab fragment of a blocking antibody recognizing a signaling subunit of the IL-15 receptor, IL-2/15Rbeta, had a ..
- Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II)Hui Xiang
J Chromatogr A 978:153-64. 2002..In this study, by using His6-tagged protein Fab OPG C11 from Escherichia coli fermentation as a model, we found that the presence of low concentrations of EDTA-Mg2+..
- Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stabilityAhmad Waseem
Programme in Oral Oncology, Oral Diseases Research Centre, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Biochemistry 43:1283-95. 2004..The keratin filaments in human epithelial cells were also disrupted by a monovalent A45-B/B3 Fab fragment, suggesting that the binding of the antibody, rather than cross-linking, collapses the filaments...
- Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibodyYiwen Li
Department of Immunology, ImClone Systems, 180 Varick St, New York, NY 10014, USA
Blood 104:1137-44. 2004..development and characterization of a fully human anti-FLT3 neutralizing antibody (IMC-EB10) isolated from a human Fab phage display library...
- Application of antigen retrieval by heating for double-label fluorescent immunohistochemistry with identical species-derived primary antibodiesHidetoshi Ino
Department of Neurobiology C1, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
J Histochem Cytochem 52:1209-17. 2004..Among them are methods using monovalent secondary antibodies, such as Fab fragments. Soluble immune complexes consisting of primary and monovalent secondary antibodies are first formed...
- Risk factors of myelodysplastic syndromes: a case-control studyS S Strom
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Leukemia 19:1912-8. 2005..The distribution by French-American-British (FAB) type was 67 (19%) refractory anemia (RA), 38 (11%) refractory anemia with ringed sideroblasts (RARS), 43 (12%) ..
- Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulinMartin S Zand
Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
Blood 107:2895-903. 2006..b>Fab'2 fragments of rATG had reduced proapoptotic activity, which was restored by coincubation with Fc fragments, and ..
Research Grants76
- Chimeric IgG/A Tumor ImmunotherapyKEITH WYCOFF; Fiscal Year: 2013..As proof of concept we will link the Fab domains of an anti-HER2 antibody to a fusion of the Fc ?1 CH1-CH2-CH3 domains and Fc ?2 CH2-CH3 domains...
- JEFFREY VICTOR RAVETCH; Fiscal Year: 2016..project goals are to discover the mechanisms by which anti-HIV antibodies can prevent or treat infection (through Fab-mediated neutralization and Fc-mediated effector functions) and how HIV can escape through mutation, critical ..
- A new technology for preclinical development of functional bispecific antibodiesLee A Henderson; Fiscal Year: 2010..In particular, next generation therapeutics derived from monoclonal antibodies (e.g. Fab, scAb, scFv, immunotoxins, etc) show great clinical promise in treating a range of human disorders including ..
- Rapid isolation of high-affinity human antibodies from large synthetic librariesMatthew P DeLisa; Fiscal Year: 2010..In particular, next generation therapeutics derived from monoclonal antibodies (e.g. Fab, scAb, scFv, immunotoxins, etc) show great clinical promise in treating a range of human disorders including ..
- Infant immunoprophylaxis against a primate lentivirusRUTH MARGRIT RUPRECHT; Fiscal Year: 2012..3. Isolate novel nmAbs through screening of Fab libraries obtained from bone marrow aspirates of monkeys with high-titer, cross-clade neutralizing antibody (nAb) ..
- Elderly Immune Response to Pneumococcal PolysaccharideM A JULIA WESTERINK; Fiscal Year: 2010..1B. Cloning and expressing the paired variable regions obtained in Specific Aim 1A into identical Fab expression vectors...
- Stuart J Frank; Fiscal Year: 2014..We will characterize inhibitory properties of two anti-GHR antibodies and Fab fragments in signaling studies, also assessing impact of PRLR expression...
- Study of the structure, function and regulation of gB, the fusion protein of HSVRoselyn J Eisenberg; Fiscal Year: 2013..In collaboration with Dr. A. Steven (NIH) we will visualize WT gB and mutant proteins bound to Fab fragments of gB Mabs...
- Zibo Li; Fiscal Year: 2016..The feasibility of these approaches will be tested with EphB4 antibody, F(ab')2, and Fab. The success of these novel imaging and therapy approached could enable breast cancer diagnosis, make possible ..
- Targeting RAGE/Abeta interaction with single chain monoclonal antibodiesEstelle Leclerc; Fiscal Year: 2012..We have recently generated a Fab fragment antibody phage display library targeting RAGE...
- Structural Basis of Antibody-Mediated Neutralization of HIVPamela J Bjorkman; Fiscal Year: 2012..The following specific aims will be pursued: 1) Solve crystal structures of bNAb Fabs and bNAb Fab-gp120 complexes to define the essential features of broad and potent HIV neutralization...
- Novel Methods for Dissolving Blood ClotsGUY LELAND REED; Fiscal Year: 2010..In Aim 1 we will engineer and express a chimerized antibody and antibody fragment (Fab)...
- Lisa A Cavacini; Fiscal Year: 2016..It is also known that Fab fragments or scFv molecules of CD4i antibodies are significantly more effective at neutralizing HIV than the intact ..
- Protective Human Anti-Candida AntibodiesMason X Zhang; Fiscal Year: 2013..the classical pathway in an Fc-dependent manner or through the alternative pathway in a novel Fc- independent Fab-dependent manner. However, M1g4, an IgG4 variant of M1g1, activates the alternative pathway only...
- Arturo Casadevall; Fiscal Year: 2014..program proposes four aims: 1) To determine the structures and antigen contact residues for V-region identical Fab fragments derived from IgG1, IgG2a, IgG2b and IgG3;2) To identify the amino acid that mediate isotype-related ..
- Technology to Optimize scFvs for Targeting TherapeuticsMARK FEDERSPIEL; Fiscal Year: 2007..have greatly facilitated the initial identification of a variety of antibody reagents, including scFv and Fab antibodies, with virtually any possible specificity...
- Arthur A Vandenbark; Fiscal Year: 2014..RTL treatment of EAE will be evaluated after blocking cell binding with RTL-specific Fab. Early and downstream T cell activation will be evaluated after ligation of the TCR with cell bound cognate and ..
- Chaperone Assisted CrystallographyAnthony A Kossiakoff; Fiscal Year: 2012..g. DNA-protein interactions) and stabilize such complexes. v) "co-chaperones" in the form of Fab-binding proteins that can be engineered to introduce anomalous atom types for MAD phasing and alter surface ..
- EDWARD FRANKLIN PLOW; Fiscal Year: 2015..has been developed, have been shown to be specific for their target Plg-R, and can be administered in vivo as Fab fragments to inhibit inflammatory responses...
- Discovery of antibodies that bind G protein-coupled receptorsMatthew P DeLisa; Fiscal Year: 2012..g., fab or fv)...
- Michael G Rossmann; Fiscal Year: 2016..We plan to use three types of labels: Fab fragments of antibodies, heavy metal clusters;and the removal of the more exposed glycans on the E protein surface...
- Monobody for Renal InflammatonJames W Larrick; Fiscal Year: 2011..For example, the anti-Fc-alphaRI Fab A77 blocks renal inflammation induced by ureteral obstruction or anti-glomerular basement membrane antibodies (..
- STEVEN ELIAS MANSOOR; Fiscal Year: 2014..will be performed in the presence of two toxins that are known to stabilize the desensitized state as well as with Fab fragments from conformation-specific antibodies...
- Engineering Hetero-Bivalent Ligands to Inhibit IgE Clustering on Mast CellsZIHNI BASAR BILGICER; Fiscal Year: 2013..via designing hetero-bivalent molecules that simultaneously target two nearby binding sites located on the Fab domain of an IgE: the antigen binding site;and the not-so-well-known "nucleotide binding site"...
- KATHARINA LUISE DUERR; Fiscal Year: 2015..Furthermore, co-crystallization with FAB fragments from conformation-specific antibodies will be tested to reduce conformational heterogeneity in the ..
- Antibodies Recognizing Quaternary Differences in HIV Envelope Glycoproteins (K08)MARK DANIEL HICAR; Fiscal Year: 2013..I will study these novel native human Ab sequences by cloning them into Fab and full-length Ab expression systems...
- PAUL STEPHEN MARINEC; Fiscal Year: 2014..Subsequently, I will genetically fuse non-human leucine zippers onto the carboxy-terminal ends of the Fab scaffolds...
- FAB LIBRARIES TO DISCOVER VACCINE LEADS AGAINST HIV-1Jamie Scott; Fiscal Year: 2000..The repertoire will be expressed and displayed as Fab-fusions to filamentous phage, and will be screened against recombinant HIV-1 envelope protein to find binding Fabs...
- Development of Novel Immunoconjugates for Application in Cancer TherapeuticsDOUGLAS DEAN YOUNG; Fiscal Year: 2010..The incorporation of p-acylphenylalanine into the Fab (fragment, antigen binding) region of an antibody can provide a convenient way to rapidly and efficiently generate ..
- Intramolecular Immunoassay for Probing Paracrine SignalingRobert G Lowery; Fiscal Year: 2010..We will achieve this by tethering a fluorescent tracer on a flexible polypeptide linker to IgG and Fab fragments engineered with seleno cysteine residues for site specific modification...
- JINDRICH H KOPECEK; Fiscal Year: 2016..The system is composed of a pair of complementary coiled-coil peptides forming antiparallel heterodimers;Fab'fragment of the 1F5 anti-CD20 antibody;and HPMA copolymer...
- Alex Y Strongin; Fiscal Year: 2015..Design and evaluate the anti-tumor activity of the highly selective and potent, active site- targeting, inhibitory Fab/scFv human antibodies to MT1-MMP...
- Structure-based expansion of neutralization ability of KD-247, an anti-V3 mAbStefan Sarafianos; Fiscal Year: 2011..In preliminary results, we have solved the crystal structure of the unliganded antigen-binding fragment (Fab) of KD-247 at the highest resolution (1.55 E) reported for any humanized antibody to date...
- CHARACTERIZATION OF SEXUAL PHEROMONES IN APLYSIASHERRY PAINTER; Fiscal Year: 1993..The active factors will be characterized by compositional and microsequence or FAB/MS analyses, and the sequences synthesized for use in HPLC coelution studies (to verify the native sequence) and in ..
- PROTEOLYTIC ANTIBODIES FOR TREATMENT OF PSORIASISROBERT BALINT; Fiscal Year: 2009..proteolytic activities with potentially unprecedented catalytic efficiencies from large libraries of antibody Fab fragments containing proteolytic V( domains...
- NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIESKeith Mostov; Fiscal Year: 1999..In either case, the antibodies should be efficiently taken up by the pIgR at the apical surface. Fab fragments of these antibodies will be used to study transcytosis from the apical to the basolateral surface...
- ANTIGEN SPECIFIC RESPONSES TO BORRELIAJorge Benach; Fiscal Year: 2007..have been discovered that can kill Borrelia burgdorferi without[unreadable] the assistance of complement, and the Fab fragments of the antibodies have[unreadable] the same bactericidal activity...
- SMALL HOLLOW NANODELIVERY VEHICLES FOR CANCER TREATMENTRichard Baldwin; Fiscal Year: 2009..The efficacy of NDVs functionalized with HER2 targeting Fab'fragments and containing two different types of chemotherapeutic drugs will be tested in cell culture and in a ..
- Towards a Model of Fanconi AnemiaBEVERLY JO TOROK STORB; Fiscal Year: 2010..To assess the role of disrupting FANCB in canine cells we will use AAV mediated HR...
- Structural studies of PKR regulation by viral non-coding RNAGRAEME LESLIE CONN; Fiscal Year: 2013..receptors, and incorporation of specific binding sites for other proteins (U1A or a recently developed RNA Fab) that can promote crystallization...
- Synthetic Fabs for Crystallization of Chemokine:Receptor ComplexesTracy M Handel; Fiscal Year: 2013..To this end, the use of Fab (fragment antigen binding) and other scaffolds has emerged as an important approach for crystallization of ..
- Polysaccharide Antibody RepertoiresAlexander H Lucas; Fiscal Year: 2010..B cells or their clonal products will be sequenced and affinity analyses will be performed on monoclonal Fab fragments...
- Low pH-mediated membrane biosynthesis in S. mutans.Robert G Quivey; Fiscal Year: 2010..fatty acids;2) we will use biochemical and molecular tools to determine the mechanism of genetic regulation of fab genes and the role of fabR in regulating the fab gene cluster;3) we will use biochemical and genetic tools to ..
- Membrane Protein Expression CenterRobert M Stroud; Fiscal Year: 2013..4) presentation of membrane proteins for optimization of Fab fragments as crystallization chaperones...
- ROBERT GERD SALOMON; Fiscal Year: 2014..via TLR2 receptors on endothelial cells contributes to choroidal neovascularization ("wet AMD"), and that anti-CEP Fab or soluble TLR2 fragment "decoy receptors" can therapeutically block this angiogenesis;and (2) T- and B-cell ..
- HIVRAD: Structural approaches to vaccine developmentEllis Reinherz; Fiscal Year: 2009..In conjunction with the hsCD4-HIV-1 gpl20-17b Fab complex, the information offers structural insight into how the AIDS virus has morphed its envelope protein to ..
- JOEL BARRY BASEMAN; Fiscal Year: 2015..TX three dimensional structure in the presence and absence of its cofactor NAD;neutralizing monoclonal antibody Fab fragments;and surfactant protein-A (SP-A)...
- Timothy J Ley; Fiscal Year: 2014DESCRIPTION (provided by applicant): Although most patients with Acute Promyelocytic Leukemia (APL, FAB M3 AML) have good outcomes, 15% still die from relapsed disease...
- Toll-like Receptors and Innate Immune Activation in Alzheimer's DiseaseBRENT DAVID CAMERON; Fiscal Year: 2013..Pathological hallmarks of the disease are the deposition of beta amyloid (fA2) protein as insoluble, extracellular fibrillar amyloid plaques in the brain parenchyma and intraneuronal ..
- TAUSEEF TAHER CHARANYA; Fiscal Year: 2015..Conjugation of the Fab fragments with an NIR dye would further allow for deeper tissue penetration complimented with higher detection ..
- Retinoic Acid Paradox and Promyelocitic LeukemiaEthan Dmitrovsky; Fiscal Year: 2013Acute promyelocytic leukemia (APL;FAB M3) has a balanced t(15;17)(q22;12-21) that rearranges theretinoic acid receptor[unreadable] (RAR[unreadable]) and promyelocytic leukemia (PML) genes...
- JOSEPH ANTHONY PICCIRILLI; Fiscal Year: 2016..application, we propose a potentially transformative approach to RNA crystallography in which we use recombinant Fab (antigen binding fragment) technology to develop an integrative pipeline for application of chaperone assisted RNA ..
- Bispecific antibody pretargeted immunoPET of prostate cancerWilliam A Wegener; Fiscal Year: 2012..The key features of this imaging system is the use of a unique recombinant, humanized tri-Fab bsMAb with divalent binding to the tumor-associated antigen, TROP-2, and another monovalent-binding Fab reactive ..
- IgE-guided RNAi silencing of FceRIb expression as a novel allergy therapeuticKe Zhang; Fiscal Year: 2013..molecules targeting for FceRIb expression silencing are complexed with the conjugates composed of the anti-IgE Fab fragment coupled to the positively charged cationic polymer polyethylenimine (PEI)...
- F-18 Labeled Peptides for Pretargeted PET Imaging of Pancreatic CancerWILLIAM JOHN MCBRIDE; Fiscal Year: 2010..g., Fab'or scFv)...
- Timothy A Springer; Fiscal Year: 2016..states, will be examined by employing different mutations, and measuring affinities for ligand and six Fab specific for the closed headpiece, open headpiece, or extended conformations...
- Achieving Therapeutic Antigent-Specific Tolerance in Type 1 DiabetesMatthias G Von Herrath; Fiscal Year: 2011..of hyperglycemia can occur at lower dosages of the systemically acting immune modulator, in our case anti-CD3 Fab'2...
- Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian CancerJINDRICH H KOPECEK; Fiscal Year: 2011..Each construct will contain multiple copies of two anticancer drugs (paclitaxel and gemcitabine) and of Fab'fragment of the OV-TL16 antibody (complementary to OA-3 antigen expressed on the majority of human ovarian ..
- CHARACTERIZATION OF THE PEMPHIGUS FOLIACEUS ANTIGENGrant Anhalt; Fiscal Year: 1993..The investigators have recently shown that monovalent Fab fragments of the autoantibodies (AAb) are pathogenic and produce the disease faster and more efficiently than the ..
- FLUORESCENT AND LARGE METAL CLUSTER COMBINATION PROBESRichard Powell; Fiscal Year: 1999..8-3.6 nm) that are covalently linked to multiple fluorescent entities and to Fab' antibodies; 2) Fab' antibody conjugated Nanogold clusters (1...
- Chemical Models of Protein beta-Sheet InteractionsJames Nowick; Fiscal Year: 2009..The investigators will study the binding of cyclic chemical models of the CH1 domain of Fab to protein G domain III, to gain insight into interactions between protein beta-sheets and to determine what is ..
- Anti-Flavivirus ImmunotherapeuticsEILEEN NAKANO; Fiscal Year: 2001..In Phase I a combinatorial human Fab library will be constructed, and Fab fragments which recognize either E or NS1 proteins will be identified...
- Characterization and Development of a Coiled-Coil to Treat Non-Hodgkin LymphomaMichael Jacobsen; Fiscal Year: 2013..For application in the apoptosis induction system, the CCE peptide was covalently attached to an anti-CD20 Fab', while multiple CCK peptides were conjugated as multiple grafts to a water-soluble polymer: N-(2- ..
- FAA AND FAD GENES AND PROTEINSManuel Buchwald; Fiscal Year: 1999..Intragenic complementation will be investigated by introducing FAB and FAA mutations into cDNA expression constructs, co-transfecting the FAB and FAA mutants into FA-A cells and FA-B ..
- POLYCLONAL ANTIBODY LIBRARIES FOR C PARVUM THERAPYJacqueline Sharon; Fiscal Year: 1999..To generate the polyclonal antibody libraries, Fab phage display libraries will first be created by recombinant Dna techniques from mice immunized with various ..
- Dissecting the functions of a novel cis element Promoter Targeting SequenceJumin Zhou; Fiscal Year: 2007..gene where the regulatory region is organized into segmental-specific domains by insulator DNAs such as Fab-7 and Fab-8...
- 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASEJAMES STOOPS; Fiscal Year: 2002..A 3-D structure of anti-bait domain Fab-labelled native alpha2M will locate this important functional site and make it possible to compare it with the ..
- 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASEJAMES STOOPS; Fiscal Year: 2001..A 3-D structure of anti-bait domain Fab-labelled native alpha2M will locate this important functional site and make it possible to compare it with the ..
- ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSISReginald Chukwuocha; Fiscal Year: 2000..test this, we plan to do the following: 1) Generate by the combinatorial library approach a large panel of IgG APA Fab fragments from APS patients with elevated titers of serum APA and recurrent thrombosis; classify these Fab ..
- Complement-fixing Bi-Specific Antibodies Against HIV-1ROBERT BOACKLE; Fiscal Year: 2007..These spatial distributions limit the ability of adjacent lgG1 antibodies to deposit in a manner that allows the Fab regions to maximally expose the Fc region and obtain a high affinity interaction with C1q globular heads...
- ROLE OF SUGARS IN PHAGOCYTOSIS OF ROD OUTER SEGMENTSEDWARD KEAN; Fiscal Year: 1991..Interference in this process has been observed upon coating the membranes with Fab fragments obtained from polyclonal anti-rhodopsin IgG...
- Role of GPI-Anchored CD52 Glycoprotein in Sperm FunctionAlan Diekman; Fiscal Year: 2003..S19 Fab fragments were shown to inhibit human sperm-zona pellucida tight binding implicating CD52 itself or a CD52-..
- PEMPHIGUS AND PEMPHIGOIDLuis Diaz; Fiscal Year: 1999..in the pathogenesis of acantholysis; d) we have demonstrated the pathogenic nature of PF IgG4 autoantibodies and PF Fab' fragments in PF...
- STRUCTURAL ANALYSIS OF THROMBIN SPECIFICITY SITSHENRY JAKUBOWSKI; Fiscal Year: 1991..The approach used will be to raise polyclonal and cloned Fab antibody fragments to synthetic peptides derived from the 3D structure of thrombin...
- 10-BORON LABELED ANTIBODIES IN CANCER THERAPYM Hawthorne; Fiscal Year: 1992..MF-(20 mer)n], is monofunctional and is reacted (one each) with free thiol functions in fragment species such as Fab or an engineered Fab-SH, both of which are derived from anti-CEA T84.66 hybridoma...


text:
Positioning and stabilization of the cargo position for jib cranes
€ 36,90
Lieferbar innerhalb von 2-3 Tagen
Dezember 2014
BeschreibungThe monograph deals with selected issues associated with steering of working movements of the jib cranes. Three methods of final positioning of the cargo crane in the slewing of the upper structure have been proposed. They vary not only with the algorithm and the structure of the control system but also with the required measurement equipment. In case of cranes founded on the moveable base, in particular the offshore cranes, the problem of stabilization of the cargo position is important. A way to solve this problem is presented in the book. It assumes the simultaneous use of drives: drum winch and special auxiliary system. The work contains description of the crane models: the basic one, taking into account flexibilities and damping in the selected subsystems, its modifications and simplified models used in the optimization tasks. The results of the indirect verification of the basic model are also presented. A physical model of the rotary crane has been used, to carry out experimental verification of one of the methods of final cargo positioning.
PortraitAndrzej Maczynski is an academic teacher of the University of Bielsko-Biala. His research interests are mainly connected with the dynamics and control of machines, in particular the dynamics of cranes. He is interested also in the Intelligent Transport Systems. He is the author or co-author of approximately 80 publications.
Untertitel: Selected problems of steering jib crane's working motions. Paperback. Sprache: Englisch.
Verlag: LAP Lambert Academic Publishing
Erscheinungsdatum: Dezember 2014
Seitenanzahl: 144 Seiten
Format: kartoniert


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