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The 2013 AMA All Star National Flat Track Series gains support from European tire manufacturer GoldenTyre through US importer, CC4 LLC. This agreement will insure competitors with great tires at more reasonable prices, with contingency money opportunities for amateur competitors, and an increase in the points fund for professional racers at all 2013 AMA All Star National Flat Track Series rounds. GoldenTyre will also assist the Series with unique and engaging marketing strategies while introducing their brand to the American market.
GoldenTyre is officially the Spec Tire for the 2013 AMA All Star National Flat Track Series in the amateur and professional classes utilizing 19′ wheels. The new CC5 and CC4 tires were inspired through rigorous testing by Chris Carr, 7-Time AMA Grand National Champion. Competitors wishing to pre-order their tires can contact Chris Carr, owner of CC4,LLC, at (610) 888-3518 or via e-mail at: email@example.com.
Chris Carr, CC4 LLC: "I can think of no better place than the AMA All Star National Flat Track Series to introduce the GoldenTyre Brand of flattrack tires to the amateur and pro flattrack market. Steve Nace and his crew have done more to promote amateur flattrack racing than any single organization in recent memory. I look forward to providing additions to the pro points fund as well as contingency programs for the amateurs in what has become a great series of races".
Marco Cavallini, Goldentyre President: " We are extremely excited to start this collaboration with Steve Nace and Chris Carr. We believe that Flat Track is the root of American Motorcycle Racing and we are happy to be able to work with the All Star Flat Track series and Chris Carr to bring innovation and a fresh push to this discipline."
Steve Nace, All Star Series President: "We believe this collaboration will be positive for the sport of flat track. We are excited to bring a new, affordable product to the racers. GoldenTyre & CC4 LLC have put forth great effort in the design & developement of their competition tires. We are thankful for the opportunity to introduce both the professional and amateur competitors of American flat track racing to this new competitive tire through the AMA All Star National Flat Track Series by GoldenTyre. Not only will this initially double the professional points fund, it will also give the amateur racers a chance to earn tires through a contingency program."
For more info on Goldentyre and All Star Flat Track Series check out www.goldentyreusa.com – www.stevenaceracing.com


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If Nicks can't go again, we still have Cruz, Hixon, Randle, and Barden as well as Eli's ability spread the ball around
As long as we win, I dont care if Nicks played or not.
keith rivers is gonna be vital against the run
Can't we just crush up some Doan's pills and Tussin' and mix it up in their oatmeal or something?.....lol....tough guys though, I think they will all be playing very soon! :)

subset: commoncrawl


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Im gonna be going in this!
Anyone else gonna be there?
Reposting the info from the page above here.
Well be hosting our fourth annual Quattro de Mayo celebration at GoodSpeed Performance Lab on May 5th (Saturday), 2012. A big thank you to GoodSpeed for hosting us again this year. For those of you that couldnt make it last year, we had over 50 Audis in attendance ranging from R8s to a Coupe GT from the 80s and everything in-between. So bring your Audi and get ready for a nice day of chatting with fellow Audi owners, checking out some nice cars, a BBQ lunch, and a nice tour of GoodSpeeds facilities.
Who is invited:
Anyone that appreciates Audis. We do ask that non-Audi cars are parked behind the shop as there is limited parking space and we typically take up the entire front lot. Your car doesnt have to be a show car to attend, any Audi new or old will be appreciated and enjoyed.
Well start at noon and it will continue all afternoon long. Around 5 or so some folks will head over the Scottsdale Pavillions car show for the after party
15001 N. Hayden Road
Suite 101
Scottsdale, AZ 85260
The Audi parking will be in the front lot. Please sign in at registration as you pull-in to be entered in the raffle.
Why attend?
Great cars & great people
Raffle for prizes from GoodSpeed Performance Lab, Audi North Scottsdale and others
Free to attend
Family friendly
We do please ask you respect the facilities and the neighboring businesses and do not peel out or drive irresponsibly when entering/exiting the parking lot.
Likewise, if youre interested in volunteering, wed love help registering people, grilling, and other miscellaneous tasks. Wed also gladly accept anything donated for the raffle to give away. Please contact us if youre interested in helping or donating using the form found here: http://www.audiclubaz.org/contact


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Don't just take it from us! We have tens of thousands of satisfied patients, hear from some of them below.
I had my surgery done 3 weeks ago and conducted two follow-up exams, and I must say that I am overwhelmed with gratitude toward these people. People at this office are very friendly and accommodating. They made me feel comfortable to discuss all my issues. They are all very knowledgeable and attentive. I had never Continue Reading »
Dear Dr.Benjamin, The staff at the Laser Eye Associates was great! The whole surgery took less than fifteen minutes and most importantly, was almost painless. I was able to go back to work in two days following the surgery. My procedure was a life changing experience. I can now fully enjoy my life with 20/20 Continue Reading »
Thanks for making me look picture perfect! I love being glasses free.
Dear Marina, Dr. Benjamin, and entire staff: I want to thank the Benjamin Eye Institute for restoring my 72 year old eyes to such fantastic 20/20 vision. Being a very active senior pro tennis player and coach, seeing 20/20 is very important. The Institute's and Dr. Benjamin's tremendous ability to do such accurate work on Continue Reading »
I was -16 and now I can see 20/20 thanks to my cataract operation with Crystalens peformed by Dr.Benjamin. Many Thanks!
I was unsure about having cataract surgery even though i knew i needed it. When my driver's license exam came up, I finally decided to do it. I didn't realize what a difference it would make, everything was brighter. I decided to have the Crystalens and now I can read without reading glasses and work Continue Reading »
Thank you Dr.Benjamin for helping me to see again. I will tell anyone that I meet about your professionalism and your genuine caring for your patients.
Read about Dr. Benjamin's own LASIK Experience. It feel like I was born again. LASIK changed my life as a patient and as a doctor. Guys, I highly recommend it to anyone who does LASIK and cataract surgery for a living! Without glasses or contacts Right Eye (OD) Left Eye (OS) Before the procedure 20/800 Continue Reading »
My name is Jean Manibog and I am 72 years young. I was referred to Dr.Benjamin by my ophthalmologist at UCLA. He stated that Dr.Benjamin was certainly the best physician for my procedure, removal of cataracts for both eyes. My left eye had a severe visual problem including a cataract. I could not read from Continue Reading »
Dear Dr.Benjamin, After dealing with the burden of glasses for many years, I am very glad to be glasses free. The entire process from start to finish was easy and your staff made me feel totally comfortable. My only regret is not having LASIK sooner!


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Iran cracks down on media before election
By Yeganeh Torbati
DUBAI (Reuters) - Iranian authorities have arrested more than a dozen journalists in the past two days over their links to "anti-revolutionary" media, Iranian media reported, in what appeared to be a coordinated crackdown on the press.
With a presidential election five months away, Iran's clerical leadership appears to be tightening its grip on the media to avoid a repeat of the widespread protests that erupted after the disputed election in 2009.
Journalists working for reformist newspapers Arman, Bahar, Etemaad, Shargh, and the Aseman weekly - and Iran's economy-focused ILNA labor news agency - were arrested on Sunday for cooperating with Persian-language "anti-revolutionary" news outlets, Mehr news agency reported late on Sunday.
The exact numbers were not known, but several outlets reported the arrests, with Fars news agency saying around 11 journalists were arrested on Sunday on the orders of the judiciary. In addition, the opposition Kalame website said a reporter for Bahar and a journalist for ILNA were detained on Saturday.
While not calling for outright dissent, the outlets have reported on an economy struggling under Western sanctions imposed over Iran's disputed nuclear program, and often feature criticism of Iranian government policies.
Shargh was banned for several months in 2012 for publishing a cartoon deemed insulting to veterans of the Iran-Iraq war, while ILNA closely follows news of layoffs in Iran's factories - bad news for the leadership in the run up to June's election.
The economy has taken a battering since the introduction of U.S. banking sanctions a year ago that virtually severed links to the global financial system. Iranians have seen the price of food and goods soar and their spending power slump, especially on imports that are directly affected by the weakening rial.
HOUSE ARREST Continued...


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Judgment of the Court (Ninth Chamber) of 21 March 2013.
European Commission v Italian Republic.
Failure of a Member State to fulfil obligations - State aid - Aid granted by the Italian Republic to the Sardinian shipping sector - Commission Decision 2008/92/EC declaring that aid incompatible with the common market and ordering its recovery from the beneficiaries - Failure to implement within the prescribed period.
Case C-613/11.
published in the electronic Reports of Cases (Court Reports - general - 'Information on unpublished decisions' section)


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America Ferrera Moving To New York For Life After 'Ugly Betty'
As the canceled Ugly Betty shoots it's final episodes, the show's star, America Ferrera, has been focusing on her next career moves. She's done a couple of movies recently including an animated film and a comedy.
While the show has been shooting in New York, Ferrera still had a home on in Hollywood. Now she's planning on selling it and moving to New York full time "for career reasons." Sounds like Ferrera has a plan. Does that mean she won't be focusing on TV?
Here's some photos of the cast filming some of their final scenes (tear).


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New Home 3678452-????
Welcome to the Quilting Board!
New Home 3678452-????
A few more....some of these are already rehomed.
Kenmore 29
Kenmore 43
Singer 9W
Eldredge B
Its treadle irons refurbished
Singer 27 Godzirra
Singer 24
Singer 328K future repaint and treadled
Time for another German machine - Frister and Rossmann transverse shuttle from 1937. The date is actually stamped on the underneath of the cover. Believe me, this machine weighs a ton, it's an absolute monster if you see it side by side with the Vesta. It's bliss to use, and of all my machines it winds the tightest most even bobbin. As for the porcelain handle, it keeps your hand nice and cool while you're sewing.
Note the seam guide in place
On the Singer 185j, where is the serial number? I have tried locating it on mine and I just can't seem to located it. I have quite a sewing machine collection too. I love sewing machines. I started out with a singer treadle that was my mother in-law's godmother's. It need some refinishing to the cabinet. It all went down hill (according to my husband) from there. I have portables and machines in cabinets. I display them all over the house. Well, some of them anyway, others are in a shed waiting to be refinished and the machines cleaned and oiled.
Muv that machine is drop-dead gorgeous!!! You are so lucky t have that beauty.
Oh wow! This is the best thread ever. I love looking at everyone's beauties. Can't wait to see more.
I know Billy said only pictures here and info on machines, but Muv's German machines are gorgeous! Muv please keep the pictures coming of your collection and join our chatting about vintage machines on this thread: http://www.quiltingboard.com/t-43881-1202.htm
And welcome!
Singer 401G (German) and Singer 411G (German) - notice the knock out for a treadle on the lower right corners. Also notice they are a bit different from the 401A (American) http://www.quiltingboard.com/t-43881-1202.htm#3520792
Singer 401A and Singer 411G with 401G behind the 411G
Singer 401 and Singer 401G
Singer 411 with extended bed - attachment drawers slightly open
i can't send pics , think something messed up when put reuter on computer . machine kinda looks like the '27' on page 6 except for modern stuff it looks like somebody took old machine &parts of 1952 era & made this machine .


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Or can I just sandwich it inside out, stitch three edges, turn it right side out and blind stitch the last edge? I'm trying to save some time..Or will that look stupid?
Printable View
Or can I just sandwich it inside out, stitch three edges, turn it right side out and blind stitch the last edge? I'm trying to save some time..Or will that look stupid?
Sure you can do it like that, but I wouldnt leave the entire last side undone., just leave an opening big enough to turn the quilt back through. When done like this they are usually tied, but I think some have quilted them this way too.
It feels like cheating..lol..But This quilt has to be done in the next 3 days..So I'm trying to shave some time off..Plus I've never done the binding before..My hubby is loving it already and the top is not quite together yet..Close though
Sure hope to see pictures of it :wink:
Once you turn the sandwich & close it, if you stitch all the way around, about 1/2" to 3/8" from the edge, it will look similar to binding. A faux binding! :D
Originally Posted by zyxquilts
I done several just the same way.
You can also leave 1-2inches of the backing extended and turn the back to the front and machine stitch down. I have done that in the past. M
The no-binding method is called "birthing a quilt" and, to my way of thinking, if a technique has a name, it isn't cheating! Here is just one of many sites with instructions. http://www.fabriclandwest.com/quilte...hing_quilt.htm
I've seen them with ruffles around it and boy was it nice.
Last year at the wings falls quilt show they had a display of old quilts, and some of them were finished this way...others appeared to be turned under and sewn


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Wed, Dec 21, 2011 at 9:33 AM
It's better to give than recieve
♥:: It's better to give than recieve, So I decided to get all the clothes and shoes that my daughter and I are not wearing and *GIVE* it to the Religious Center. Why hold on to it if we not wearing it?? When its people out there that need it!!! SN:: 4 days till Christmas :) ♥ Happy Holidays Barbz :)) ♥ *ABM&NELLY*
No one has commented yet.


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Member News
Winter Culinary Salon at Dorsey!
- Monday, 18 February 2013
What an exciting weekend at Dorsey Culinary Academy! Chefs from around the Midwest and East Coast traveled on a snowy Friday evening to participate in the Winter Culinary Salon II hosted by Dorsey Culinary Academy in conjunction with the Michigan Chefs de Cuisine Association! Read More.


text: I got in my truck last night and my screen said service traction control. I read in the manual on how to reset it however I couldn't get it to work. A guy I work with knows more about those model chevys than I do and I'm going to get him to see what he can do. Any info will be greatly appreciated! Also if I have to take it to the dealer any ideas on how much it will cost? Thanks in advance!


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Torque Reaction Arm/Assembly Arm
Product Announcement from FlexArm/Tapping & Torque Arms
See our demonstrational VIDEO at www.flexarminc.com
FlexArm's Torque Reaction Arm provides added value as an articulating arm that supports assembly tools used in repetitive operations. Increase productivity and reduce operator fatigue by adapting assembly tools to the Assembly Arm. Maintain quality levels by accurately positioning the tool and reduce the chances of damaging or scrapping parts.
Ergonomically beneficial, the FlexArm absorbs the motor torque instead of the operator's arm and counterbalances the weight of the tool. The Torque Reaction Arm rotates a full 360 degrees and covers large work areas without expensive fixturing and excessive physical strain.
- Counter Balance Tool Weight
- Absorb Motor Torque in Torque Arm
- Custom Tool Mounts: Mount Any Tool
- Light Duty and Heavy Duty Arms up to 800 Ft/Lbs Available
- 30 Day Free Trial
Part Saved
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For more information:
|More Info


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Create a free account to check out faster, store multiple shipping addresses, view and track your orders in your account, and much more.
Please enter your password to continue.
This is one of my favorite nail polishes! I use a cobalt blue as my base color with 2 coats of Across the Universe. Super sparkles! I'm almost distracted while typing!5


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Linking up with Amy today from At the Pink of Perfection for the first ever Saw Pinned Conquered!
This was such a great idea and I can't wait to share some of the recipes we've tried recently!
A couple of weeks ago, I found the Healthy Beef and Black Bean Enchiladas recipe...
Source: canyoustayfordinner.com via Savanah on Pinterest
These were so good and flavorful... it was hard to believe they were pretty healthy too!
2tsp olive oil
2 cups slice bell peppers (any color)
1 medium onion sliced
2 cloves garlic minced
8oz lean ground sirloin
1 15oz can black beans drained and rinsed
1T chili powder
1T ground cumin
1/2 tsp papricka
pinch cayenne pepper
1/2 tsp salt
12 6" whole wheat tortillas
1 16oz jar hat salsa divided
1 cup shredded Monterrey jack cheese or any blend you like
1. Preheat oven to 350.
2. Heat a large skillet over medium high heat. Add olive oil, swirling to coat. Add the peppers and onions and saute for about 5 minutes, until softened. Add the garlic and stir for 30 seconds.
3. Add ground beef and use a fork to crumble it. Cook for about 4-5 minutes, or until the mixture is no longer pink.
4. Stir in the chili powder, cumin, paprika, cayenne, salt, black beans, and ¼ cup of the salsa. Mix well.
5. Spread half of the remaining salsa over the bottom of a 13×9" baking pan.
6. Lay your tortillas on a clean work surface and spoon a heaping ¼ cup onto the center of each. Roll tightly and line them up, closely packed into the baking pan, seam side down.
7. When all of the tortillas have been filled and placed into the pan, evenly pour the remaining salsa over the top.
8. Sprinkle the pan with the cheese.
9. Bake for 20 minutes. Allow the enchiladas to cool for about 10 minutes before serving. Garnish with sour cream and fresh cilantro.
My final product...
Changes I made:
-We used a whole pound of ground beef. I don't like to save ground beef and we buy them buy the pound so it was just easier to use all of it. I ended up saving some of the beef/black bean mixture and just eating it the next day with some tortilla chips and it was really good!
-Because we used extra meat, we had extra enchiladas. We ran out of them, that's why there's an empty space.
Things I would do different:
-Stupid me didn't double the spices for this when I doubled the meat. It was still good, but probably would of had a lot more flavor had we doubled the spices for more meat.
-I really think a packet of taco seasoning could do the trick... Instead of adding all the spices, I think next time I'll try adding taco seasoning to see how it turns out!
-Use a bigger skillet! :) I made a huge mess because the skillet was not big enough for a pound of meat plus all the add ins!


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eGov Services • 1300 Perdido St, New Orleans, LA 70112 • (504) 658-4000
Home » Mayor's Office » Press Releases
Subscribe to the Mayor's Press Release feed
NEW ORLEANS — TODAY, Mayor Landrieu will welcome leaders of the International Association of Francophone Mayors (A.I.M.F.) who are visiting New Orleans as part of their annual conference that brings together French-speaking mayors from the United States, Canada, Europe, the Middle East and Africa to discuss major initiatives of the A.I.M.F., including the development of tourism in Francophone cities and the contribution of the French language in political, economic and artistic development.
NEW ORLEANS – The City of New Orleans has been selected as a finalist for the City Accelerator, an initiative of Living Cities and the Citi Foundation that works with cities to help accelerate the adoption of innovative practices to improve the quality of life for residents.
NEW ORLEANS —Tomorrow, City officials will host a media availability to discuss a new initiative that will use data analytics to target homes in New Orleans that are least likely to have smoke detectors and most likely to have fire fatalities, and then distribute free smoke detectors to those homes.
NEW ORLEANS – This week, the City of New Orleans successfully sold $65 million in taxable public improvement bonds to improve streets, parks and playgrounds, public libraries and other public buildings. The sale came on the heels of Standard & Poor's (S&P) upgrading the City's credit rating to A- from BBB+ due to economic growth and sound fiscal management by the Landrieu Administration.
NEW ORLEANS – Today, Mayor Mitch Landrieu announced he has appointed two senior officials to help lead the City's efforts to strengthen economic development and create more economic opportunities for New Orleans residents. Landrieu appointed Rebecca Conwell to serve as the Mayor's senior advisor for economic development and Ashleigh Gardere as the Mayor's senior advisor for economic opportunity and director of the City's Network for Economic Opportunity.
NEW ORLEANS – Today, the City of New Orleans issued a traffic advisory to temporarily close portions of Washington Avenue and Drexel Drive in the Gert Town neighborhood near Xavier University. The City is currently constructing an elevated pedestrian crossing over Washington Avenue, the Washington Avenue Drainage Canal and Drexel Drive.
NEW ORLEANS– Mayor Mitch Landrieu and the NOLA FOR LIFE Services Collaborative today unveiled a 12-month pilot project to promote opportunity and health for at- and high-risk boys and men of color, and announced that the City will begin accepting applications from providers for the project.
NEW ORLEANS – Government Technology magazine has named Oliver Wise, director of performance and accountability for the City of New Orleans, to its Top 25 Doers, Dreamers & Drivers – 25 individuals or teams who exemplify transformative use of technology that's improving the way government does business and serves its citizens.
NEW ORLEANS—The City of New Orleans Health Department has issued notices of noise variances to New Orleans residents in the Iberville neighborhood for Thursday, March 26, 2015. Residents are advised to be patient and expect to hear loud noises outside of the normal hours outlined in the City's noise ordinance.
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The Marshall County Community Foundation is accepting applications until Monday, Feb. 2 for the first of two 2015 Community Fund grant rounds.
Grants are awarded from this fund twice a year with money going to nonprofit organizations. The funds support projects or programs in Marshall County focusing on the arts, education, health and human services, recreation and the environment.


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Pearland United is a recreational and competitive soccer club serving Pearland, Texas and surrounding communities. Pearland United also offers a TOPSoccer program for the disabled and mentally challenged. At Pearland United, the club offers affordable soccer development programs.
- Professional training provided by experienced & licensed trainers
- Group academies for U5/U6, U7/U8, and U9/U10s
- Team training for D3, D2, S2, and D1 levels
- Goal Keeper training
- Experienced & licensed coaching with Regional & State playoff experience,
- Overall personal development for the player,
- Soccer skills – technical and tactical
- Sportsmanship,
- Teamwork,
- Physical and mental readiness,
- Preparation for high school or collegiate programs,
- Other Club activities
- Soccer camps,
- Internal friendlies,
- Pearland United – competing and succeeding, plus we make it fun!
Mission Statement
Our mission is to provide a challenging and enjoyable soccer experience for all players and coaches. Our purpose is to promote and advance the game of soccer among our youth by providing affordable soccer development programs for the youth of Pearland and surrounding communities. We strive to develop fundamental and advanced technical skills among our players to enable them to participate at both competitive and recreational levels while instilling sportsmanship, teamwork, and physical health. As such, we employ experienced coaches and trainers with the utmost respect for our youth and adherence to ethical and quality standards.
Pearland United … Good for our youth!


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You missed it This great deal for The Eye Doctors is over. But don't despair, we've got more great deals every day.
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The comprehensive eye exam uses state-of-the-art equipment to check for nearsightedness or farsightedness, and also looks for systemic diseases that can affect your eyes. Optomap imaging will be used to get a full picture of your retina.The optical staff has received numerous clinical honors, so you're in good hands.
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text:
|Número de publicación
|Tipo de publicación
|Número de solicitud
|Fecha de publicación
|7 Jul 2009
|Fecha de presentación
|11 Sep 2002
|Fecha de prioridad
|12 Sep 2001
|También publicado como
|Número de publicación
|Ronald J. Pettis, Frank E. Martin, Scott A. Kaestner
|Cesionario original
|Becton, Dickinson And Company
|Exportar cita
|BiBTeX, EndNote, RefMan
|Citas de patentes (27), Citada por (56), Clasificaciones (25), Eventos legales (3)
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet
This application claims the benefit of U.S. Provisional Patent Application No. 60/318,913 entitled "Microneedle-Based Pen Devices For Drug Delivery", filed Sep. 12, 2001, and U.S. Provisional Patent Application No. 60/318,886 entitled "Microneedle-Based Pen Devices For Drug Delivery And Method", also filed Sep. 12, 2001, both of said provisional applications being incorporated herein by reference.
The present invention relates generally to substance delivery pen devices. Specifically, the invention relates to an injection pen device and method that incorporates microneedle systems for the user interface.
Currently, several pen systems are available for subcutaneous substance delivery. These pen systems typically use 31 gauge needles having a length of about 8 mm and are used to deliver the contents of a cartridge, such as insulin, to patients rapidly and as painlessly as possible. Additional details of intradermal drug delivery have been previously described in U.S. patent application Ser. No. 09/835,243, filed Apr. 13, 1999, and Ser. No. 09/417,671 filed Oct. 14, 1999, the entire content of each application being incorporated herein by reference.
Although currently available pen systems utilize designs manufactured to maximize patient comfort, a need exists for a "microneedle" pen system which can offer an inherent advantage in the reduced pain and sensation to the user resulting from the minimal penetration associated with the extremely small microneedles used. Such microneedle drug delivery systems however, require shorter needles, typically less than or equal to 3 mm, and smaller diameters of 34 gauge or less. Such needle lengths and gauges are required due to depth constraints and bevel edge openings, which are required to access only the deep intradermal or shallow subcutaneous tissue space. Simple modification of current pen systems used for subcutaneous delivery is not possible because of severe engineering constraints associated with the size and volume restrictions imposed by the use of microneedles.
Therefore, a need exists to provide a system and method for the incorporation of microneedle systems as the pen outlet, or user interface. As this results in significant changes in the in vitro and in vivo function of the pen system, additional engineering requirements and methods of use are also required for the effective function of the pen device.
An object of the present invention is to provide an injection pen device that incorporates microneedle systems for the user interface.
Another object of the present invention is to provide an injection pen device which has a sufficiently open fluid path to allow ready transport of a liquid or suspension from a cartridge to a microneedle inlet, without requiring excessive pressure or occlusion.
Another object of the present invention is to provide an injection pen device which has a biological interface composed of one or more hollow cannula which can penetrate the stratum corneum and accurately access the desired tissue depth in skin or in the proximity of skin.
Another object of the present invention is to provide an injection pen device which has a biological interface that can transmit a desired fluid volume through the body of the interface into a specified or targeted tissue depth both accurately, with no fluid loss out of tissue to surface or to untargeted tissue, and efficiently, in a manner that is amenable to the device user and recipient.
Another object of the present invention is to provide an injection pen device which has a fluid delivery mechanism that can provide the high pressures necessary for fluid delivery to the dermal or near dermal space, withstand pressure and compression, inherent in the fluid delivery to the targeted tissue space, and is easily activated by the user to deliver the fluid.
Another object of the present invention is to provide an injection pen device which can be maintained in an orientation or configuration with respect to the patient's skin for a sufficient time period to accomplish delivery.
These and other objects are substantially achieved by providing a system and method for a substance delivery pen device which includes a hub assembly, removably engaged with a pen body housing containing a cartridge for holding a substance to be delivered, and a non-compliant and non-compressible plunger at one end of the cartridge driven by a drive mechanism.
The hub assembly has at least one microneedle suitable for deep intradermal or shallow subcutaneous injection of a substance, and a fluid channel suitable for connecting the microneedle and the cartridge. Activation of the drive mechanism causes pressure to be exerted on the plunger in contact with the cartridge causing the contents of the cartridge to flow from the cartridge, through the fluid channel and the at least one microneedle, and into the deep dermal or shallow subcutaneous region of the patient.
The hub assembly can include a microneedle array having one or more microneedles as required by the application and can removably engage the pen body housing through, for example, a threaded assembly or a Luer lock. The hub assembly can further include a mechanism for skin tensioning during or before use of the pen device. The tensioning mechanism can include a number of member combinations, including skin tensioning rings and depth limiting posts located on the skin contact surface of the hub assembly. The hub assembly further includes a mechanism, such as a backend needle, for piercing the septum of the cartridge, and receiving the contents as driven by the plunger. The plunger can be, for example, a rod or circular screw drive, engaged with an actuator used to exert pressure on the plunger through a linear screw drive, a ratcheting means, a spring, air pressure or other mechanical means.
Further objectives and advantages, as well as the structure and function of preferred embodiments will become apparent from a consideration of the following description, drawings and examples.
These and other objects, advantages and novel features of the invention will be more readily appreciated from the following detailed description when read in conjunction with the accompanying drawings, in which:
In the drawing figures, it will be understood that like numerals refer to like structures.
For pen delivery devices, various microneedle systems can be incorporated to function both as the drug outlet and the biological interface with the patient or enduser. In the embodiments of the present invention described below, the microdevice pen device includes a single or multineedle-array pen needle head, or hub assembly, that is used as a simple screw-on attachment, adaptable to a variety of currently manufactured pen devices.
The embodiments also incorporate a post and ring configuration in which each cannula of the hub assembly protrudes from a member, such as a post, surrounded by a valley, and is then circumscribed by an additional member, or ring of a height relative to the internal post. This arrangement assists in skin tensioning, limits needle penetration, and allows an area for formation of the intradermal bleb or wheal during injection.
The embodiments also include an improved drug cartridge, which minimizes elastomeric compression through the use of a polytetrafluoroethylene, or PTFE stopper. The embodiments include an improved drive mechanism which further decreases elastomeric compression, increases mechanical advantage, accuracy and perception of individual unit increments, and generates end-of-dose locking capabilities. Still other embodiments utilize improved drive or compression mechanisms.
A diagram of an exemplary hub assembly 10 in accordance with an embodiment of the present invention is shown in
A raised skin tensioning member, or ring 12, is located about the contact surface circumference as shown in
The microneedle 14 can include any number of needle gauges, lengths and construction, however, needle gauges less than or equal to 30 gauge (nominal size specification of less than or equal to 0.012 in. outer diameter and 0.004 in. inner diameter) are typically used. The microneedle length is preferably between about 0.3 mm and about 5.0 mm depending upon application. For example, lengths of between about 0.3 and about 2.0 mm are used for intradermal delivery, and lengths between about 2.0 and about 5.0 mm are used for shallow subcutaneous delivery. These values may slightly overlap due to biological variables such that microneedle lengths slightly less than 2.0 mm may be used shallow subcutaneous delivery, and microneedle lengths slightly greater than 2.0 mm may be used for intradermal delivery. The microneedles can include a number of materials, such as stainless steel, silicon or silicon compounds, polymers or plastics. Alternatively, a microneedle pen can utilize larger gauge cannula with appropriate length and bevel characteristics to still maintain accurate fluid instillation to the intradermal space without topical deposition to the skin surface.
As shown in
Proper operation of the pen device requires the backend needle 22 of the hub assembly 10 in
Therefore, the embodiment of assemblies 10 and 40 shown in
In both
When a microneedle system is used for in vivo delivery, such as delivery to an intradermal space, a significant backpressure is encountered due to instillation rate of fluid volume into an essentially sealed or closed space having limited distensibility. This is true even though intradermal delivery of substances, such as medications involve much smaller volumes of liquid, 100 microliters for example, as compared with the volumes used in subcutaneous systems, which can be as large or larger than 500 microliters. The magnitude of backpressure is also proportional to both the instillation rate as well as the volume. This level of pressure is not typically encountered when delivering a substance to the subcutaneous space, which is generally regarded as a region of highly compressible or distensible tissue with a much higher limit for instilled fluid volume. By utilizing a multi-port frontend hub assembly, as shown in
As noted earlier, intradermal delivery via a single 34 gauge microneedle, as shown in
A skin tensioning member, or ring 54, discussed in more detail below, is located about the circumference of the surface 60, and about each limiting post and support hub 52, as shown in
As stated earlier, a significant backpressure is encountered during drug placement due to instillation rate and fluid volume placement into an essentially sealed or closed space. In another embodiment of the present invention, these pressure differentials can be further decreased by the use of microneedles of different lengths in
Additional features, beyond needle specifications, can assist in providing appropriate and efficient penetration of the pen microneedles. The embodiments shown in
In the single needle embodiment shown in
The top view of the hub assembly of
The skin tensioning members of
Other methods of skin tensioning can be incorporated as an alternative to the ring and post system described above. Such methods of skin tensioning can include transiently applying a brief initial vacuum to the injection site, manually or mechanically pulling or stretching the skin, or utilizing a mechanically controlled rapid insertion. For example, ballistic inserters result in brief inertial stiffening of the skin, reducing effective elasticity. These mechanisms can be used either singularly or in combination, or with other techniques readily known to those skilled in the art.
As shown in
In use, a cartridge 68 is located within the delivery pen device 80 and contains a substance to be dispensed. At the end of the cartridge opposite the septum 64, a drug cartridge stopper 70 is in communication with a plunger 72, slidably engaged within the pen body 66 and driven by a known type of drive mechanism 73. The backend needle 42 pierces the drug cartridge septum 64 when the hub assembly 44 is engaged with the pen body 66. The drive mechanism 73 is activated via an external user interface 74, which then causes the plunger 72 to exert a force on the stopper 70. This force moves the stopper 70 within the cartridge 68, forcing the contents of the cartridge toward the exposed end of the backend needle 42, into the fluid pathway 58 and out through the microneedles 50.
Since the in vivo biomechanical requirements for delivery into the intradermal space are significantly different than those for delivery to the subcutaneous space, the physical and mechanical components and mechanisms of pen delivery systems must be considered to insure effective dosage delivery. Particular modifications of the pen structure itself are dictated by the extremely high backpressures generated upon intradermal instillation of even small volumes of fluids.
In particular, systems or components that have the potential for elastomeric compression are not suitable for the microneedle pen systems of
As force per unit area is decreased for larger drug vials or cartridges, a minimal cross sectional cartridge area is preferred for microneedle pen systems as described above. Microneedle pen embodiments typically utilize 1.5 ml insulin-type cartridges, rather than the 3.0 ml versions which are used in other applications. A single unit dose pen for intradermal systems benefits by providing a small diameter dosing cartridge typically having a longer length than larger diameter cartridges. This improves compressive force levels on the fluid bed due to the reduced cartridge cross-sectional area and allows accurate volume quantitation in a manner similar to small volume microliter syringes. Therefore the embodiments of
Additionally, the plunger 72 of the pen device 80 is constructed of a non-compliant and non-compressible material. The material is sufficiently resilient to communicate an appropriate force from the actuator to the stopper 70, however, the plunger 72 will not bend nor tend to be compressed along its axis, leading to "shortening" under the pressures required for operation of the pen. In addition, the end of the plunger 72 in communication with the stopper 70 exerts a substantially even force on the stopper 70 during operation, and prevents leakage from the cartridge around the sides of the stopper or plunger. Suitable materials that fit these requirements include polymeric materials such as rigid plastic materials, and metallic materials such as stainless steel. Additional pen component materials can include metals, plastics, ceramics, and so forth.
Effects of increased pressure also translate to the body and mechanical components of the pen drive mechanism 73, which are also constructed of polymeric components in most current pen devices. For effective delivery, the drive mechanism components must have sufficient strength to translate these forces to the drug reservoir and also to withstand forces translated backward to prevent breakage, malfunction, or other failure. Therefore appropriate materials choices are also necessary in the drive mechanism 73. Typical pen drive mechanisms 73 include circular drive screws, linear drive screws, ratcheting drives, and stored kinetic energy, such as mechanical spring or air pressure.
In the embodiment shown in
As stated above, embodiments of the present invention can incorporate a drive mechanism with minimal elastic compliance of all parts, either singly or together. Other embodiments can incorporate drive mechanisms having well-defined stops, steps or ratchets at each dosing increment to insure dose accuracy. These stops enable ease of use by "locking" the drive in an advanced position, which is especially important to signal end of dose. Still other embodiments utilize a linear or other driving force that confers a significant mechanical advantage when actuated by thumb pressure, or other force generated by the user. Additional embodiments can utilize a mechanical force that can be actuated and forgotten, such as a spring, having a readable gauge to signal end-of-dose.
For embodiments having cartridges that store multiple doses, a unit dose counter 76 can also be incorporated into the device 80 in
With most currently manufactured pen screw drive systems, physical force is applied to the top of the pen to drive an advancing screw. This increases the tendency to push down on the device during use. Reducing downward force levels may be achieved in a number of ways. One solution to eliminate excessive downward force utilizes a user actuated mechanical drive to expel the fluid contents. Another solution utilizes a modified patient contact surface angle.
In one embodiment of the present invention, a user actuated mechanical drive releases stored kinetic energy that is generated in the pen mechanism in a separate step prior to actuation, such as the use of a mechanical spring to actuate fluid flow. The low force spring in the device is able to effectively deliver fluid through both single and multineedle microarrays when used in vitro. Other mechanical means include air pressure generated mechanically, chemically or electromechanically. Mechanical drive systems that have efficient force amplification, such as altering the drive ratio of circular gear drives for physically applied pressure, such as thumb pressure, can also be used.
As described above, pressure generated directly at the site of fluid instillation is another issue unique to microneedle delivery systems that must be considered in the design and manufacture of microneedle pen devices. When tissue immediately above or around the intradermal instillation site is compressed, the already high tissue pressure is increased. This can lead to leakage along the microneedle track, either during administration with needles in situ in tissue, or post administration along the tissue track. In pen based systems, this effect is further exacerbated since the user is trying to maintain a perpendicular orientation of the device to the skin, maintain intimate contact of the microneedles in the tissue, and exert a downward force on the screw drive of the pen to expel the fluid or drug. This effect may be reduced or eliminated by the post and ring components of
Additional reduction of the adverse effects due to excessive pressure can be achieved by angling the patient contact surface of the pen head relative to the axis of the pen device with an offset angle of 0-90 degrees. This reduces the tendency to press too firmly against the tissue face and therefor reduces tissue compression forces. An example of an embodiment of the present invention in which the contact surface of microneedle hub assembly is no longer perpendicular to the center axis of the pen device is shown in
In the hub assembly 82 of
The embodiments described above for a microneedle based pen system for effective drug delivery to the intraepidermal, intradermal, or shallow subcutaneous (hypodermis) space include features such as a sufficiently open fluid paths to allow ready transport of the liquid or suspension from the cartridge reservoir to the microneedle inlet without requiring excessive pressure or occlusion. Also included is a biological interface composed of one or more hollow cannula which can penetrate the stratum corneum, and accurately access the desire tissue depth in skin or in the proximity of skin, and transmit a desired fluid volume through the body of the interface into the specified or targeted tissue space both accurately, with no fluid loss out of tissue to surface or to untargeted tissue, and efficiently, in a manner that is amenable to the device user and recipient.
Other features include a fluid driving mechanism that can overcome the high pressures inherent for fluid delivery to the dermal or near dermal space. A device mechanism, components, and assembly process is provided which withstands the additional physical forces, such as pressure and compression, inherent in the fluid delivery to the targeted tissue space. The device mechanism and configuration which is easily activated by the user to deliver the fluid to the targeted tissue space, can be maintained in an orientation or configuration for a sufficient time period to accomplish the delivery. The delivery pen system described above serves to reduce pain due to instillation, provide better access to the desired tissue space, and provide better or beneficially altered drug pharmacokinetics or pharmacodynamics.
Although only a few exemplary embodiments of the present invention have been described in detail above, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the following claims.
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Owner name: BECTON, DICKINSON AND COMPANY, NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:PETTIS, RONALD J.;MARTIN, FRANK E.;KAESTNER, SCOTT A.;REEL/FRAME:013283/0867
Effective date: 20020911
|7 Ene 2013
|Fee payment
Year of fee payment: 4
|28 Dic 2016
|Fee payment
Year of fee payment: 8


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text: We got our hands on the New Micromax LED40K360 40" LED TV. We tried searching about it online but couldn't find anything, nothing on the Micromax site as well. After much research we got to a conclusion that is actually a Hisense LED TV, which is being marketed in India with the name of Micromax. So, We did a review of it. The Micromax LED40K360 40 LED TV as sits on a rectangular Stand (wall mounting option is also available) and dressed all in Piano black finish weighs 13 kgs. The screen quality is good and does manage to deflect most of the light falling on it from external sources. The 45-degree tilt of the panel makes placing the Micromax LED42K316 42 inch LED TV in the room fairly easy. [TABLE="class: tr-caption-container, align: center"] [TR] [TD][/TD] [/TR] [TR] [TD="class: tr-caption"](1, 2) Input Ports (3) Menu, Channel, Volume, Power Buttons[/TD] [/TR] [/TABLE] The rear of the Television houses all the controls and connectivity post which is laid out in a L shaped manner. What impress us are the 3 HDMI & 2 USB 2.0 options available. When we first received the unit, it was hard to switch it on, why? There is an un-needed power on/off button located on the bottom of the bezel without which the unit will not powering. The Menu, Source, Volume, Channel and power buttons are hidden behind the right hand side of the screen which are relatively easy to spot and access. We were really unhappy with the quality of the remote, which comes with the TV. Its clear that there was no research done and the ergonomics weren't taken into consideration at all. The panel of the Micromax LEF40K360 40 inch LED TV has an aspect ratio of 16:9 and the levels of black are deep giving a nice contrast ratio. Though you could fiddle around with the setting the colors do become deep at certain points and the picture becomes over saturated. With a screen resolution of 1920x1080, videos when viewed in HD do look good on the display but performance cannot be really expected out the Micromax LED42K360 40" LED TV. With a slow 6ms response time and 60Hz Motion rate the pictures tend to blur out on fast action sequences. Motion rate of 150+Hz is considered to be ideal. The problem also arises when you're viewing SD content on the TV, the lack of an upscaling feature delivers pixilated content. Though the backlighting on the panel is quiet acceptable unlike the rest of the Micromax LEDs out there. The basic menu setting and easy to access customization options along with the TV remote make setting the TV according to your preferences a breeze, though the option to change the advanced settings is not available. The Audio of the Micromax LED42K360 40" LED TV failed to impress us as well. The 5.0 SRS WOW inbuilt system fails to live up to the expectation and it is highly advisable to invest in a Speaker system along with the TV. The Panel also features a Standby light at the bottom center of the panel, which we found to be brighter than needed. Many features like Low power consumption, manual tuning, screen freeze on this TV are quite gimmicky and we found them to be useless. Though this TV is just a rebranded Hisense LED TV Micromax has done a good job of introducing with a 40 Inch LED TV in a price range of Rs. 28,000 and that's is its only USP. Our Rating : 7/10


text:
Sunday, 5 May 2013
observer ONLINE
Southern expressway extension from Galle to Matara by
year's end:
By Ranil Wijayapala
"To provide an adequate and efficient network of national highways,
to ensure mobility and accessibility at an acceptable level of safety
and comfort, in an environment-friendly manner for the movement of
people and goods in the socio-economic development of the nation", was
the mission of the Ministry of Highways when it completed the National
Road Master Plan (NRMP) in 2007, after a great effort was made for two
years commencing from 2005.
The preparation of the National Road Master Plan was in conformity
with the Mahinda Chinthana manifesto presented by President Mahinda
Rajapaksa aiming 'to provide accessibility to all population in the
country and to have a high and quality mobility road network for the
transportation of passengers and goods' in its effort to making Sri
Lanka the 'Wonder of Asia'.
The preparation of the NRMP was a timely effort firstly because the
'transport in Sri Lanka is overwhelmingly roads-based and a large
portion of the network is in a poor condition and has become an
impediment to efficient transport'.
Secondly, it is a key input into overall national income generation,
the Government's development strategy has to count on a reliable
transport system and the support from a coherent long-term approach to
transport development. Thirdly, Sri Lanka's integration in the global
economy rests also on efficient transport logistics, which, among other
factors, is a determinant of the country's trade competitiveness'.
Therefore, the NRMP gave strong emphasis for the construction of the
Expressways and Highways and it accounts for the highest share (36
percent) in the NRMP investment and gave emphasis on six major projects
with a length of 594 km and an estimated cost of Rs. 238.3 billion
spread over the entire program period of the NRMP spanning from 2007 to
The construction of Colombo-Katunayake expressway (25.1 km), Southern
Expressway (130 km), Outer Circular Highway (28 km), Colombo Kandy
Expressway (98 km), Colombo-Jaffna Expressway(213 km) and the Extension
Southern Expressway (100 km) were the major projects that have been
given top most priority by the NRMP.
Sri Lanka saw the first outcome of this NRMP prepared under the
directive of President Mahinda Rajapaksa, when it opened the first ever
'E' grade road on November 27, 2011, heralding a renaissance in the
highways sector of the country providing faster connectivity to the
southern part of the country.
However, it was only a part of a bigger project of connecting the
southern town of Matara to the metro Colombo and the balance of the
project is now underway to complete the entire project providing access
to southern city of Matara within one and half hours.
When the first phase of the Southern Highway which was opened on
November 27, 2011 is now operating in full swing with an average of
10,000 vehicles operating on the highway on daily basis earning a daily
income of the Rs. 3 million per day to the Road Development Authority
the second phase of the project is also now going on at a speedy phase
to be completed by the end of this year.
According to Project Director of the Southern Highway, Nimal
Chandrasiri more than 60 percent of the work of the project from
Pinnaduwa to Godagama has been completed by the contractors.
"The project was due to be completed at the end of April but due to
various factors the contractor could not complete the project and now
they have been asked to complete the project by August this year. They
are trying their best to complete the project and we hope that the road
will be ready by the end of this year," Chandrasiri told the Sunday
According to Chandrasiri, the original design of the expressway was
drafted as a two-lane design, previously stretching from
Kurundugahahetekma to Matara, was changed later to expand the highway to
a four lane highway. By the time the design was changed more than 11
kilometres out of the 30 kilometres stretch from Pinnaduwa to Godagama
have been constructed and that section is now being expanded to a four
lane road.
The section from Pinnaduwa (Galle) to Godagama which is about 35km is
financed by the Export and Import Bank of China.
"This stretch of the highway will also have the same features the
first section of the road from Kottawa to Pinnaduwa and there will be
three interchanges to connect the main cities in the south with this
highway", he said.
The first interchange after Pinnaduwa will be at Imaduwa, to connect
the highway with Galle-Akuressa Road. The other interchange will be
there at Kokmaduwa. "Presently we called that interchange as Kokmaduwa
interchange and there is a possibility to change the name as Weligama
interchange. That interchange will connect the highway with
Weligama-Kananke Road", he said.
The last interchange will be at Godagama to connect the southern
expressway to Matara via Akuressa-Matara Road.
"The Godagama interchange will be a temporary one like the Kottawa
interchange which was there at the opening of the highway and it will be
fully changed once the southern highway is extended upto Beliatta", he
This section of the project will have four bridges, 46 underpasses,
12 box culverts and 236 pipe culverts.
He said the extension of the Southern Highway from Godagama to
Beliatta is now at the designing stage and the Godagama interchange will
be fully constructed once the Godagama-Beliatta section of the highways
is constructed under a different project.
According to Chandrasiri, at the final stage the highway will be
extended upto Hambantota and Mattala and that part of the project is
under designing stage.
Asked whether there are any changes in that section of the project
based on the feedback they receive from the motorists he said there were
no major criticism over the first section of the Southern Highway.
"At the initial stages there were criticism that the paved part of
the road is not sufficient for the vehicles to park by the side of the
road in an even of a breakdown of a vehicle. However, this has not
become a problem as yet because the road is not congested. There is no
huge traffic along the road. The road is not having traffic sufficient
for two lanes even. Therefore, that will not be a problem at all since
the road is having four lanes. The traffic of the road will be gradually
build up in the years to come according to the projections we made when
the road was designed", he said.
"When we are calculating the toll for the road we are calculating how
the traffic will increase on the road and we have calculated the traffic
along the road to recover the project cost within 40 years after the
completion of the road. We are taking a traffic projection when we are
doing that calculation and we are within that projections", he said.
"We are targeting to improve this highway into a six lane highway. In
the second section of the road also we are clearing the trace to
accommodate six lanes. We are leaving that stretch for earth filling
when the construction is going on", he said.
"Once completed this highway will enable to reduce the travel time
from Colombo to Matara from four and half hours to one and half hours to
two hours", he said.
The project will help improve transport facilities for future
development of Southern Region and it will act as a catalyst in
encouraging and attracting industries and services for the Economic and
Social development of the region. It will also promote inter-regional
transport facilities by developing this road, considering it as a major
component of the proposed expressway network.
The main objectives of the project are also aimed at reducing the
travel time between Colombo and Matara, reduce traffic congestion on
Colombo-Matara Road, and reduce delay costs, fuel costs there by
contributing to national economy. Attracting private sector investors
and there by contributing to expand the job market, development of
fisheries, agriculture, industries in the region, expanding tourism
presently confined to the coastal belt, along Colombo-Galle-Matara to
more inner areas of the southern province, development of Galle Port,
Development of the towns belong to 11 interchanges as Economic Centres
and enhancing the value of land and property in the region are also
among the objectives to be achieved under this project.
However, the people of the country will be able to enjoy the true
benefit of this expressway once this highway is connected to the other
expressways which are now under construction, through the outer circular
highway which is being built as a ring road to connect all these
expressways together giving easy access to all parts of the country as
stipulated in the National Road Master Plan.
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text:
Black unhittable in Smokies' win
Cubs prospect rebounds from first start with five shutout innings
By Robert Emrich / MiLB.com | April 11, 2014 11:38 PM ET
Corey Black has settled into his new organization and couldn't be happier about it.
The Cubs' No. 17 prospect tossed five no-hit innings Friday night but did not figure in the decision as Double-A Tennessee walked off with a 6-5 win over Chattanooga.
Black struck out two and walked three while facing four batters over the minimum. After struggling through the first two innings, he retired the final 10 Lookouts he faced, throwing 44 of 79 pitches for strikes.
"Really, all I had was my fastball," Black said. "I was throwing a lot of two-seams and missing a lot of barrels. They were popping it up."
His Southern League debut on April 5 was a different story, as the 22-year-old right-hander surrendered two runs on five hits over two innings. Black noted that the biggest change was the difference in conditions between Smokies Park and Pensacola Bayfront Stadium.
"I didn't have anything to push off and I was leaving balls up," he said. "I was really able to keep the ball down [tonight] and give my guys a chance to make a play for me, especially when I wasn't getting ahead of hitters. I think I only had one or two first-pitch strikes."
Black came over from the Yankees on July 26 in the trade for veteran slugger Alfonso Soriano. He made five starts for Class A Advanced Daytona following the deal but was able to use the offseason to get acclimated to the club.
"They invited me to January camp, which was cool to go out to Arizona and get ready for the season," he said. "The organization has been really accepting. It's a good fit and I love where I'm at."
Dustin Geiger went 2-for-3 with a two-run homer and two runs scored. The 22-year-old first baseman has homers in three of his last five games and shares the Southern League lead.
"He's seeing the ball really well, he's getting into good counts and he's making pitchers pay for mistakes," Black said. "Everyone gets into those grooves and he's hitting things on a line and squaring things up left and right."
Stephen Bruno singled home the winning run in the bottom of the ninth after the Lookouts tied the game in the top of the inning.
Armando Rivero (1-0) was credited with the win, despite yielding two runs on one hit in the ninth.
Chris Reed, the Dodgers' No. 6 prospect, tied a career high with nine strikeouts over six innings and gave up two runs on two hits for Chattanooga.
Robert Emrich is a contributor to MiLB.com. Follow him on Twitter @RobertEmrich. This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.View More


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What do 2 euros mean to you?
I have a full wallet.
It contains three hair pins, a shopping list, three phone cards, my driver's license, a credit card, and my metro pass. There's money, too, of course. A whole 2 Euros and 80 cents.
I'm broke. As a college student, I accept my dismal financial situation. Luckily, mom and dad are generously helping me fund my European excursion, and I'm able to make ends meet.
Still, everything seems to revolve around money. It's a perpetual source of relief, frustration, and inspiration. Think about all the hit songs written about money: The Beatles' "Can't Buy Me Love," Pink Floyd's "Money," but if I had to choose a theme song for this blog post, I'd choose "For the Love of Money" by the O'Jays (more commonly known to my generation as the theme song for Donald Trump's TV show, "The Apprentice," but I digress).
We're peppered with mixed messaging. Earn it, spend it, save it, share it. It's just a bunch of paper and metal, but, man, it's attractive and demanding.
Yes, materialism is superficial, but money's power is responsible for a lot of good, too. The World Food Programme is voluntarily funded, relying on donations from governments, corporations, and individuals.
If you're reading my blog, chances are you're a young, monetarily challenged individual just like me. Those of us who share this status understand its restrictions, and I'm guilty of dwelling on the "can't"s associated with empty pockets.
Luckily for me and the rest of the 2-Euro-toting young people, enthusiasm and dedication do a lot in ways money can't.
In this job, I encounter a lot of extraordinary people, many of whom can't legally drive a car. Earlier this week, I met the under-18 winner of the hunger bytes! contest — he's a 14-year-old whose striking, one-minute video calls for awareness of and action against world hunger. I receive letters and e-mails from students wanting to do school projects about hunger so they can teach their classmates about the pressing issue.
For each student who spreads the word, someone else realizes the gravity of hunger issues.
Money remains an important factor in our organisation's success, but you can't buy away hunger. Change takes passion. Progress requires dedication. From what I've seen, it's the young people with a fiery attitude who make the world listen. A bold attitude commands more attention than a big wallet — in the wake of the disasters my generation has seen, I hope we maintain that strength.
Christine DiGangi is from Chicago and is interning with WFP Youth Outreach. She loves running, chocolate, and fighting hunger.


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Trip Start Sep 20, 2007
150Trip End May 16, 2008
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"I went sky diving,
I went rocky mountain climbing,
I went 2.7 seconds on a bull name Fumanchu.
And I loved deeper,
And I spoke sweeter,
And I gave forgiveness I'd been denying,
And (then you say) he said, "Someday I hope you get the chance,
To live like you were dying."
Written by Tim Nichols and Craig Wiseman
Sung by Tim McGraw
To-Do list:
-learn to play the guitar
-go sky diving
-see Machu Picchu in Peru
-cycle through Europe
-walk my daughters up the aisle at their wedding
-hold a grand-child in my arms
-write a bestselling novel
-publish an award winning photo
-date a Famous Hollywood Actress
Done list:
-have amazing children
-have amazing parents
-walked up the Eiffel Tower
-climbed to the top of a mountain in the Rockies (Moose Mountain)
-flew in a Glider
-flew through the mountain peaks in a 4 seat Cessna
-visited Rome
-toured the USA by car (1/2 done)
-danced around like a crazy fool dressed up as Captain Canada
The book I purchased at the Country Music Museum was written by the writers of this song. It is an inspirational book that was written as the authors state..."This song told us it was a book that we would write long before we wondered if we knew how to write a book or who would publish it."
Tim McGraw wrote the forward to the book and what he says about the song is this..."Each person has his or her definition of what it means to "live like you were dying."
I would love to copy every word from this book and have every single one of you memorize them....and LIVE them! But I can't...and I won't. Why? Because you've all already seen them and read them and might...Yes, MIGHT, already be living them. Most of you see these words in the emails that get passed around every week...or passed around Facebook...or see them posted on a bulletin board at work. Sometimes they come with amazing pictures...cute babies...kittens. The words are different...the message the same. Say "I LOVE YOU" more often. Forgive someone. Say "YES" instead of "NO". Take that chance. LEAP! Failure is just a chance to try again!
This book came to me because.....(fill in the blank). If you've read every single one of my blogs you should already know what I would stay.
I am NOT dying. I don't think I am. Even if I was I would have no regrets. I believe I have done some amazing things in my life. The epitaph on my tombstone would be something I would be proud of. At the gates of Heaven Saint Peter would put a pass mark in more boxes then failures. But my life is NOT over. Far from it. My health is giving me more challenges lately. It's all part of the Journey. Every so often small miracles happen as I'll explain later. Not a day goes by where I don't talk to someone who would like to join me on my Journey. My question is, "Why don't you take your own Journey?" And, "Why did I have to wait to get sick to do it?" And finally, "Why wait until you ARE dying?"
A lot of people do, do it. Get on a plane...a train...take that rusted out old jalopy out on the highway and head to Nashville...or Hollywood...or Timbuktu. At 18...25...44 , or 65. Go back to school to get that degree. Learn to play the piano. Fly an airplane. Write that book. What are YOU waiting for?
What's on YOUR To-Do or Dream List?
I feel like I should write something about "Stacy" again. I'm not even sure that's her name. The volunteer at the Museum. Every so often you meet someone and the conversation flows. She was one of those people. That got me thinking about what would happen if I did meet someone during my travels and the "sparks flew"? A friend of mine mentioned that they saw on Oprah the author Elizabeth Gilbert who wrote "Eat, Pray, Love-One Woman's Search for Everything". This woman took off and travelled to various places after a failed relationship and wrote this bestselling novel. I haven't read the book but I checked out her website and in the Q&A section someone asked if she was still with the guy she met during her journey. She is.
I'll probably never hear from "Stacy" again. I do wonder how people start long distance relationships and what happens once they meet and spend more time together.
Small miracles. I had a Vision at the Grand Old Opry.
As a child I had what was called a "lazy eye". For some period of time I had to wear a patch over my good eye so that it would force the "lazy" eye to strengthen. I was a pirate when pirates were NOT in vogue. A plastic eye patch with a rubber band around the back of the head does not make for a cool look. Lucky for me it was not during my teen age years. That corrected, a few years later I fell down the basement stairs and banged the right side of my head on the concrete. Whether that has any correlation to the fact that I have uncorrectable vision in my right eye I don't know, but I think it adds something to the sympathy feelings. It might also explain a few other things about me. As you all can see from the few pictures I post of myself I wear glasses. The lens on the right side is the strongest possible but all it does it make things less blurry. So then, even though the lens on the left side corrects my vision so that things are clear, due to my peripheral vision, things are always somewhat blurry. It's like looking through a window with Vaseline smeared all over it.
My Vision. This is a literal vision, not a spiritual vision. As I was watching the group Restless Heart perform the second song in their set I noticed that my vision was as clear as clear is possible. How was this possible? I looked around and everybody on stage was seen though perfect vision, though corrected with the lenses in my glasses. During the past year or so my eyesight has deteriorated quite a bit when it comes to reading things when I'm wearing my glasses. I'm always squinting above or below the lenses. It also explains the typos in my blog. After staring at the screen for a while my vision is quite blurry. More than usual. I don't know as of yet the meaning of that episode, but I am sure it was a sign of some kind.
Grand Old Opry, Vision-Part II. I mentioned in yesterdays blog about the duet The Wrights. When I saw their name in the program I didn't recognize it. They've been singing together for 10 years and have been married for 6. They've played the club circuit in Nashville for years. They have one album out and the second will be released the day after tomorrow (29th). They played 2 songs at the Opry from their new album. This is where things get freaky. I am positive I've seen them perform the second song in their set before. If the album hasn't been released yet does that mean the song hasn't been played in public before? If that's true then how come I could visualize them playing this song that they wrote before actually seeing them last night?
Finally, this is where my abstract thoughts comes out. Once I wake up from the "pain" in my extremities, I lay awake and my brain goes into overdrive. I can't describe how this sensation in my body feels. Another symptom that's started since my accident is the "ringing" in my ear. The doctor's call it tinnitus. The thing is it's not really a ringing in my ears. It's more like a high pitched short circuit in my head. Something like the sound you hear when you're near high voltage power lines. But different. So one night I start thinking about all my symptoms and how they relate to everything in life. On a side note, did you know that sometimes when they amputate a body part from someone, that individual can often still feel sensations in the parts that are no longer there, as though they were still there. Or something like that. There's a belief "out there" that our bodies are one giant vibrating energy field. At a quantum level we are. Studies have shown that electrical impulses are sent to our brain even before we touch something due to this "energy field" that surrounds us. So my brain that creates all these theories starts correlating the short circuit noise in my head to the "phantom" pains in my extremities. The pains must be phantom because doctors keep on insisting that I am healthy as a horse. Somehow I also think it ties in to my soul. The energy field is somehow tied into our souls. So I have a short circuit to my soul. The "phantom" pain is actually soul pain. My soul is stuck between the physicality of my body on earth and the inspirational life of my soul. Now you get an idea how my brain works. But we're just scratching the surface. My brain has even wilder theories...though they're all stuck in my head trying to get written. Oh! And the "ringing" in my head gets louder the worse my symptoms are.


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The Rev. Dr. Marcia J. Patton is the Executive Minister of Evergreen Association of American Baptist Churches which has churches in Washington state, Idaho, Utah, California and Alaska.
Evergreen Association is unique among American Baptist Churches as it organized by ethnic caucuses and does its work by consensus. Prior to her work with Evergreen, Dr. Patton was Associate Executive Minister for American Baptist Churches of the Northwest and also held pastoral positions in New Jersey, Utah and Pennsylvania. She has taught at Eastern Baptist (now known as Palmer) and Fuller Theological Seminaries. She is the co-author of When the Spirit Moves: A guide for Ministers in Transition, published by Judson Press. Dr. Patton was ordained at First Baptist Church, Salt Lake City, Utah and currently lives in Kent, Washington.
She earned a B.A. from Michigan State University in Business Education, M.A.R. and M.Div. from Eastern Baptist Theological Seminary (now known as Palmer Seminary) in Philadelphia, and PhD from Temple University. (Member since 2007.)


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Joseph 'Joe' Freeman Morton
Joseph 'Joe' Freeman Morton of Chewelah, Washington died June 30, 2006 at the age of 67 years. Joe was born May 13, 1939 in Kinzoo, PA but was raised in the Seattle, Washington area where he attended West Seattle High School and Olympic Junior College. While attending high school Joe broke many state athletic records. Joe retired as a Brewer from Anhauser Busch in Van Nuys California. Joe loved sport, hi pets and his family. Joe is survived by his wife, Anne Morton o Chewelah, Washington, his sons Sean Morton and family of Orting Washington, Joshua Morton and family of Chewelah, Washington, and Kurt Stratmann and family of Lincoln, NE, his daughters Heidi Wulczynski and family of Chewelah, Washington, Katrina Tuttle and family of Cayucos, California, Erika Barnes and family of Morro Bay California and Marie Flores and family of Abilene, KS. He has fifteen grandchildren and one great grandchild. Joe also left behind three sister; Betty Marsh and family, Sue Campbell and family and Mary Hutchings and family plus numerous nieces and nephews. Joe was preceded in death by his two sons; Brock and Gus, his parents and his brother Jack. A family get together will be held to honor Joe at a later date.


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CSJ has just released a new booklet in July covering hot articles in Chem. Lett. & BCSJ selected by CSJ Journal Steering Committee members and it will be distributed to al...
A newly updated CSJ website welcomes you giving wide variety of the CSJ topics. Join us CSJ and become a member!
The Chemical Society of Japan holds the national meeting annually in Spring, which covers all academic fields in Chemistry.
A big meeting held in Honolulu Hawaii every 5 years, where researchers and technical experts all over the world in Chemistry participate is called The International Chemical C...
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Collected lists designated as monthly Calendar helps visitor of our websites to get International Conferences information proposed from various organizations in the world.
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Chemistry Letters is a monthly, online and in print, scientific journal for the publication of Highlight Reviews and Letters focusing on current topics of all aspects of chemistry.


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When we begin to perceive the phenomenal world with a sense of basic goodness, peace, and beauty, conflict begins to subside and we start to perceive our world clearly and...
Chögyam Trungpa Rinpoche (1939–1987) was one of the most influential Buddhist teachers in the West. Visit here to read his biography, watch videos of his talks, and see a listing of his many books, as well as information about ordering them. If you would like to receive inspirational quotes from Trungpa Rinpoche's extensive body of teachings, you can sign up here for the Ocean of Dharma Quotes of the Week, an e-mail newsletter that is sent out twice a week. You'll also find the full archive of Ocean of Dharma quote below!
From time to time, you will find new surprises on this site: book giveaways and other contests, changing photo exhibits, excerpts from new and forthcoming publications, and information on programs that present the teachings of Chögyam Trungpa to new and seasoned practitioners.
If you want further information on any aspect of Chögyam Trungpa's life and teachings, you may contact Carolyn Gimian, who helps to maintain this site. Carolyn has been an editor of Rinpoche's work for the last twenty-five years. She is happy to receive your questions and comments at email@example.com.
Ocean of Dharma
When Anxiety Subsides, We See Clearly
January 1, 2013
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A New Old World
December 27, 2012
Committing yourself to the practice of meditation brings a sense of reality, that the practice is no longer a myth. It's a real experience. And having become part of your...
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The Star of Bethlehem on the Horizon
December 25, 2012
We are gazing at the star of Bethlehem on the horizon. It is far, far away, but still there is hope. A spark of luminosity is there. The land may...
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Here Comes the Sun
December 20, 2012
The sun has a sense of all-pervasive brilliance, which does not discriminate in the slightest. It is the goodness that exists in a situation, in oneself, and in one's world...
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Meditation and Mysticism
December 19, 2012
From the practice of meditation, we can experience ourselves as what we are and who we are altogether. Sitting practice is a way of discovering ourselves. This approach is compatible...
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|Brit wins 2010 CANADIAN OPEN CHESS CHAMPIONSHIP by Eric Malmsten
|Written by Steve Sperry on Tue, Jul 20 2010 (05:31)
Brit wins 2010 CANADIAN OPEN CHESS CHAMPIONSHIP
TORONTO ONTARIO – July 19, 2010. The 9-day long 47th Canadian Open Chess Championship wrapped up Sunday at the Westin Harbour Castle's Convention Centre.
The $6,500 first prize was convincingly won by 26-year-old Grandmaster Luke McShane from England. He won 7 games, and tied 2 other grandmasters.
Just before this tournament he had won $5,000 in Philadelphia so his trip to North America has been very rewarding. McShane is ranked in the top 100 in the world and when he was only eight years he won the World Under-10 Championship. McShane has an Oxford degree in philosophy and math. At the closing dinner he noted that this tournament has one of the best playing conditions he has ever played in.
The $3,500 second prize was won by 19-year-old Nikolay Noritsyn of Richmond Hill. He had 6 wins and 3 draws, he tied two of the grandmasters and in the last round defeated Lithuanian GM Eduardas Rozentalis to surge ahead. Noritsyn was the 2008 Toronto Closed Champion, 2007 Canadian Closed Champion and is a member of Canada's chess Olympiad team.
Tied for third with 7-2 were Vancouver's Jack Yoos and Grandmasters Georgian Merab Gagunashvili, American Alexander Shabalov, and Ukrainian Vladimir Malaniuk. Yoos won the Lexus Brilliancy Prize for his win over local chess teacher Felix Barrios. Yoos also scored 7 points in last year's Canadian Open in Edmonton. Shabalov enjoyed the stronger opposition the accelerated pairings created and played the first chess960 simultaneous in Canadian history.
Among those scoring 6.5-2.5 was Canadian Grade 8 Champion Joey Qin from Nepean who won top Bantam, and top juniors Aman Hambleton and Arthur Calugar. Scarborough's Hambleton had a great tournament, achieving the rare result of defeating two grandmasters and barely missed getting an International Master norm. He won the Deloitte Best Game prize for his win over GM Vladimir Malaniuk and Mark's Best Dressed player.
Tied for Top Senior over 50 with 6-3 were local players Ilia Bluvshtein and Lorne Yee. Ilia's son is a grandmaster who gave a simultaneous at the beginning of the event.
Keith MacKinnon, Saskatchewan's top player, scored 6-3 and won the second Brilliancy Prize for his win over Arthur Calugar.
Top Lady with 5.5 (ahead of 4 Toronto Women with 5) was Alexandra Botez from Burnaby, B.C. Botez was the 2009 Canadian Girls Under 14 Champion and the 2007 North American Girls Under 12 Champion.
Biggest upset prize went to Matthew Perez of Scarborough who defeated two high-ranked players.
Over 80 of the 265 players won part of the $32,000 prize fund.
Hans Jung, the Chess Co-ordinator of the City of Kitchener, gave a simultaneous blindfold but could only score 2.5-2.5. Jung also won the chess trivia contest, scoring 21-3, over 88 others.
Saturday night's 5-minute blitz tournament had 81 players and was won by local IM Artiom Samsonkin and U of T student Bindi Cheng. Cheng also won the second Best Played Game prize for his win over Maxim Dudkin.
Full results, games and photos can be seen at http://monroi.com/2010-cocc-home.html.
And for the chess-player the success which crowns his work, the great dispeller of sorrows, is named "combination."
-Emanuel Lasker (1868-1941)


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Third and final week of BLONDME giveaways and our last Hollywood blonde…
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Last week it was Kate moss celebrating in London. This week it's Claire Danes at the Roma Fiction Fest Awards winning for Best Actress in HBO's Temple Grandin. Did you watch Temple Grandin? I was nagging you to watch Temple Grandin in January. Claire's performance in Temple Grandin is extraordinary. She was just nominated for an Emmy with some very, very impressive company: Maggie Smith, Joan Allen, Judi Dench, and Hope Davis. Is it ok to love her again? Because she really, really hits it hard in this movie. SO good.
This is Claire with Hugh Dancy in Rome accepting her award. The dress is Valentino. It's like celebrities, they never worry about sitting down.
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Interested in giving the BLONDME line a try? Each week we'll be giving away a gift basket full of product courtesy Schwarzkopf Professional BLONDME valued at $99. To enter for a chance to win, email [email protected] with Schwarzkopf BLONDME #3 as the title before 11:59pm Pacific on Friday, July 16th, 2010. One basket is available per draw. Standard contest terms apply. Good luck!
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*celebrity names/images are used for editorial purposes only and have no association with the products featured in this advertorial


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