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Ovarian cancer joins the genome atlas
In the effort to fight cancer, researchers look to the genome for answers. Tumor cells grow uncontrollably, driven by genomic alterations that may hold the keys to improved diagnosis and treatment for this deadly disease. In an attempt to reveal the genetic changes that drive cancer, an international consortium of researchers including scientists at the Broad Institute of MIT and Harvard and elsewhere has been working to characterize the genomes of several cancer types. The pilot phase of the project, known as The Cancer Genome Atlas (TCGA), is now complete with a new release of data on genetic changes underlying ovarian cancer, a disease that lacks successful treatments and is the fifth-leading cause of death due to cancer among women in the United States.
The largest and most comprehensive effort to sequence cancer genomes to date, the work not only uncovers new genetic links to ovarian cancer, but it also demonstrates the power of large-scale sequencing and analysis projects to unravel the complex sources of this disease. Further, the pipeline of experimental methods and analytical tools can now be used to explore the genetic basis of many more cancer types. The work appears in the June 30 issue of Nature.
In the project's first pilot effort, completed in 2008, 600 genes were sequenced in samples from more than 200 patients with glioblastoma, a deadly brain cancer. The study also explored changes in activity levels, or expression, of genes and presence of extra or missing portions of DNA, known as copy number. The work successfully revealed new mutations and core pathways involved in the disease.
Two years ago, as the TCGA team planned the pilot phase's next target, ovarian cancer, they decided to scale up an order of magnitude by sequencing several thousand genes. At the same time, the traditional method of sequencing, known as capillary electrophoresis, was being replaced by "next-generation" technologies that enabled massively parallel sequencing and the generation of volumes of data more cheaply and quickly.
"A remarkable thing about this project was this big transition," said Stacey Gabriel, Head of Cancer and Medical Sequencing at the Broad and a lead scientist of the new study. New capabilities allowed the team to set its sights higher, aiming to sequence not just a few thousand genes, but all the protein-coding segments of the ovarian cancer genome, known as the exome, in hundreds of tumor samples, making this the largest cancer sequencing effort yet. "Now exome sequencing is fully in place due to hard work by people here at the Broad and other places," she said.
DNA misspellings aren't the only genomic modifications in tumor cells, so members of the TCGA team aim to generate comprehensive profiles of cancer genomes, as they did for glioblastoma. In addition to sequencing the exons, or protein-coding portions, of genes in 316 samples of high-grade serous ovarian tumors, along with matching normal tissue from the same patients, the team also gathered and analyzed other types of genomic data in 489 tumors, including the expression of messenger RNA and microRNA, levels of DNA methylation, and alterations in DNA copy number.
"The TCGA is a high-profile project because it brings together a really great community of everyone who's using the latest tools to generate what's the most comprehensive dataset for any cancer project," said Gabriel.
The remarkable amount of data generated in the study was subjected to rigorous analytical methods, many developed here at the Broad. The scientists discovered that the tumor suppressor gene, p53, was mutated in 96 percent of the tumors. "It's shocking that nearly all patients in the study have p53 mutations," said Gaddy Getz, director of Cancer Genome Computational Analysis at the Broad and a leader of the study's analytical effort. "In other tumor types, it's not that high, but here, it's basically all tumors."
In addition to mutations in p53, nine other genes were mutated at much lower rates in tumors, including known cancer oncogenes NF1, BRCA1, BRCA2, RB1, and CDK12, a gene never before linked to ovarian cancer. "Many of the cancer genes are recurrent, known players," said Getz. "But whenever we do these studies, we find some new players as well." Inherited mutations in BRCA1 and 2 are known to play a role in predisposition for breast and ovarian cancer, but this study revealed that some ovarian tumor cells can acquire the mutations, too, suggesting a broader role for these genes in cancer.
Led by scientists at the Broad, the analysis of DNA copy number in the samples yielded some surprising results. In the previous pilot study of glioblastoma, a few chromosomes were either amplified (present in extra copies) or deleted in many samples, but most chromosomes were present in the normal amount. Analysis of the ovarian cancer samples painted a different picture, one of "genomic disarray." Getz said, "Basically the whole genome was either amplified or deleted." Either entire chromosomes or whole arms of the chromosomes were altered. The ovarian cancer genome also held dozens of regions of smaller amplifications or deletions, many of which contain known cancer genes. "It seems that ovarian cancer is very much driven by copy number," explained Getz.
In an attempt to use genomic measurements to further classify these high-grade ovarian tumors, the research team analyzed messenger RNA and microRNA in the samples and revealed four stable subtypes with potential implications for prognosis. The data also showed that a significant portion of samples harbored genomic alterations in elements of known cancer pathways, such as the RB1 and PI3K/RAS pathways. Getz views this approach as complementary to the direct measurements of genetic changes. While individual genes contribute to the picture of a disease, taking a step back to view networks of genes can reveal larger patterns at work. "Pathway analysis is what I see as the route to getting to the additional driver genes," he said. "We find those genes significant in their own right, by copy number or mutations or combining them. But this doesn't give us all the genes that are important in cancer."
The breadth of data also shed light on the role of BRCA DNA repair genes in ovarian cancer. One-third of samples harbored alterations in BRCA1 or 2, but the data showed that these changes – germline mutations, tumor cell mutations, or hypermethylation, which effectively silenced the gene – were mutually exclusive, with samples having only one type of BRCA alteration. For BRCA1, the manner of gene inactivation seemed to influence the patient's survival.
In total, roughly half of the high-grade ovarian tumors displayed defects in homologous recombination, a DNA repair mechanism, through changes to BRCA genes and others, suggesting therapeutic potential for drugs that target this mechanism, such as PARP inhibitors. Common cancer pathways and gene copy number changes uncovered in the study also provide potential opportunities for targeted therapeutics.
Getz explained that only in a comprehensive, large-scale project like the TCGA can effects like the BRCA result be seen, with integrative analysis of several types of genomic data generated on the same samples. "I see this paper as a huge resource of very clean, high-quality data that could be used for building computational models of the relationships between different events, such as copy number events, expression levels, and mutation," he said.
The data is also a starting point for scientists to conduct cellular experiments and explore the role of specific genes or pathways in ovarian cancer. Larger datasets and new sequencing technologies that look beyond the exome may reveal even more genes and pathways involved in the disease and help to build a more complete picture of its genetic basis.
The ovarian cancer study was a collaboration of many research centers in the TCGA network. The Broad was the only institute to serve as a Genome Characterization Center, led by Gabriel and Broad senior associate member Matthew Meyerson; a Genome Sequencing Center, led by Broad director Eric Lander; and a Genome Data Analysis Center, led by Getz and Broad senior associate member Lynda Chin.
Supporting the Broad's heavy involvement in these activities required incredible teamwork by the institute's Biological Samples Platform, Genome Sequencing Platform, and Genetic Analysis Platform, said Gabriel. Now that the pipeline of experimental and analytical methods is well established, the TCGA project is accelerating beyond the pilot phase, with the Broad and other institutes currently generating data on more than a dozen additional cancer types. Gabriel explained that these efforts will be completed more quickly, because they have refined methods for exome sequencing. "Using the exome [sequencing technology] was like building the airplane while you're flying it," she said. "We all had a feeling of that. But ultimately the project took flight and we did very well. We should all be really proud of the data."
Other Broad researchers contributing to the work include Michael Lawrence, Kristian Cibulskis, Andrey Sivachenko, Douglas Voet, Kristin Ardlie, Roel Verhaak, Scott Carter, Craig Mermel, Gordon Saksena, Huy Nguyen, Rob Onofrio, D. Hubbard, Supriya Gupta, Andrew Crenshaw, Alexis Ramos, Rui Jing, Richard Park, Michael Noble, Carrie Sougnez, Wendy Winckler, Jane Wilkinson, Jennifer Baldwin, Toby Bloom, Tim Fennell, Juinhua Zhang, Hailei Zhang, CJ Wu, Sachet Shukla, Yingchun Liu, and Peter Park.
Paper(s) cited:
The Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474,609-615 (30 June 2011). DOI:10.1038/nature10166


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Lee's Summit Parks & Recreation is now taking registrations for the annual "Summer Classic" Open Tennis Tournament to be held June 20-22 in Lee's Summit. The following divisions will compete:
Men's Divisions: Open Singles & Doubles; "A" Singles & Doubles; "35" & Over Singles & Doubles. Women's Divisions: Open Singles & Doubles; "A" Singles & Doubles. Mixed Division: Open Doubles. Junior Divisions (18, 16, 14 & 12 & under): Jr. Girls Singles & Doubles; Jr. Boys Singles & Doubles.
Registration ends on June 17 at 5 p.m. Tournament fees for single events are $12.00/person/event and $20.00/Team/Event for doubles. Participants may compete in a max of 1 singles and 1 doubles event. Ages based on June 20.
Call 816-969-1500 for more information or to register or visit www.lsparks.net.

subset: commoncrawl


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Your Cat, Your Life
The Scoop
Cat News, Politics
Meow-Out-Loud Humor
Cat Chic
Gear and Glam
Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.
Cat Breeds
Foods & Treats
Health & Care
Behavior & Training
Cats & Cleaning
Cat of the Day
Photo Comments
Bari Kitty is here to save the day! No really. I can do it! I am so brave. I can attack the doggie and he whimpers and runs away. Silly boy. He is a big giant wolf looking thing. Mommi calls him a husky. His name is Loki and he is not a dog, he is a skerdy kat!
Mommi keeps getting mail for me. I think I'm getting to be popular! I love having friends. Daddy says I can have tons of friends as long as I don't invite them all over here at once!
For lunch today I gots to have some of Daddy's chicken gumbo. Mommy gave me a taste of her lunch too but spinach is ewww....green!
Now I'm going to sit in my private chair and take a nap.
Mommi is adding a new picture of me to the journal so you can see me in my chair. I was on a date!
Love & Purrs,
Mommi says that I'm the featured diary of the day on Catster. Does that mean that more peoples can come and see how prettiful I am? Will they give me treats? I sure hope so.
Guess what I did yesterday? Mommi took me outside on my leash! I like to go and eat the grass and smell stuff but I hate when she thinks that she is in charge. I'm the one in charge here! I was skered at first cause the last time I went out it was cold and there was this white stuff all over the ground. I thought it would be warm and fluffy like me but BOY was I wrong!!! It was WET and COLD and ICKY!
Well, time to go and pounce ... er I mean love my brothers!
Love and Purrs,
Copyright © I-5 Publishing, LLC. All rights reserved.
Visit Dogster


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The Nevada State Athletic Commission notified ProMMAnow.com that all 18 of the fighters tested on the World Series of Fighting 3 card have come back negative for PED's and recreational drugs. Read More »
Tag Archives: tyson steeleFeed Subscription
World Series of Fighting 3 salaries: Josh Burkman tops $200K payroll
The World Series of Fighting 3 event took place on Saturday night in Las Vegas at the Hard Rock Hotel and Casino. The main event saw Josh Burkman avenge a previous loss to Jon Fitch by submitting him in less than a minute in the main event. The total payroll for the event was $200,000. Read More »
WSOF 3 LIVE results and play-by-play
MMA World Series of Fighting returns to the Hard Rock Hotel and Casino in Las Vegas this evening for their third event. The main card is headlined with a welterweight bout between former UFC top contender Jon Fitch and fellow UFC veteran Josh Burkman. Read More »
World Series of Fighting 3 weigh-in results
The World Series of Fighting 3 card is all set to go as official weigh in's took place earlier today in Las Vegas. The event will take place at the Hard Rock Hotel and Casino and will the main card airing on NBC Sports at 11 p.m. ET. Read More »
The World Series of Fighting 3: Fitch vs. Burkman II full card
The World Series of Fighting 3 card will air Friday, June 14, on NBC Sports at 11 p.m. ET from the Hard Rock Hotel and Casino in Las Vegas, Nevada. Read More »
Pro MMA Now Radio returns tonight at 10 p.m. ET
Your weekly dose of all things mixed martial arts returns tonight with a laundry list for everyone to discuss. Titan returned to the airwaves on AXS TV and UFC on Fuel TV saw a night loaded with submissions. We will touch on those events as well as look forward to the very busy weekend ahead. Read More »
Pro MMA Now Radio is back with Abel Simmons and Tyson Steele tonight at 10 p.m. ET
After a couple week hiatus Pro MMA Now Radio is back tonight with two great guests. We will talk to Stockton UFC fan Abel Simmons who had to use some "UFC moves" to protect his family and property during an attempted carjacking following UFC 161. He's been all over the news, now we've got him on the show. Also joining us his rising Canadian MMA star Tyson Steele, who is coming off a huge win over Gregor Gracie at WSOF 1 and returns at WSOF 3 on June 14 to take on Steve Carl in the co-main event. Read More »
Gruetzemacher injured, Jeff Smith set to fight Jerrod Sanders at WSOF 3
Streaking 25 year-old featherweight (145 pounds) rising star Jeff Smith (10-1) of Harrisburg, Pa. will replace injured Chris Gruetzemacher against Jerrod Sanders (11-1) of Oklahoma City, Okla. in a World Series of Fighting Mixed Martial Arts (MMA) preliminary card bout at Hard Rock Hotel & Casino in Las Vegas on Friday, June 14. Read More »
WSOF 3: Two preliminary fights added to June 14 event in Las Vegas
Surging KO artist Chris "Gritz" Gruetzemacher (11-1) of Glendale, Ariz. will square off with fellow fast-rising star Jerrod Sanders (11-1) of Oklahoma City, Okla. in a World Series of Fighting featherweight (145 pounds) preliminary card bout at Hard Rock Hotel & Casino in Las Vegas on Friday, June 14. Read More »
Tyson Steele vs. Steve Carl to co-main event World Series of Fighting on June 14
World Series of Fighting announced today a new co-main event matchup between welterweight (170 pounds) Tyson "Man of" Steele (10-1) and Steve Carl (19-3) for the professional Mixed Martial Arts (MMA) promotion's highly-anticipated fight card at The Joint at Hard Rock Hotel & Casino in Las Vegas on Friday, June 14, live on NBC Sports Network, beginning at 11 p.m. ET/8 p.m. PT. Read More »
Ryan Ford to make Bellator debut in April
Top Canadian welterweight Ryan Ford expects to make his Bellator Fighting Championships debut in April, the fighter recently told the MMA Outsider podcast. Read More »
The MMA Outsider Podcast Episode 36 – UFC on FX/ProElite 3 Review and Aggression MMA 9 Preview with Ryan Ford and Tyson Steele
In this episode we spoke with two top Canadian fighters: Ryan Ford -- a soon-to-be Bellator fighter looking to prove he can beat the best in the world -- and top prospect Tyson Steele. The two will square off in the main event at Aggression MMA 9 in Edmonton. Read More »
Aggression MMA announces full fight card for February 11th AMMA 9 event
Aggression MMA, one of the very best fight promotions in Canada, today revealed the full fight card for its upcoming AMMA 9 event, which is slated to hit the Shaw Conference Centre on Saturday, February 11th. Read More »
Canadian Promotion Aggression MMA signs top prospect Sheldon Westcott
Aggression MMA, one of the top MMA promotions in Canada, today announced that the promotion has signed rising welterweight star Sheldon Westcott to compete on its upcoming February 11th event. The name of Westcott's opponent will be released shortly. Read More »
Aggression MMA ready to kickoff 2012 with top Canadian stars
2011 was a solid year for Aggression MMA, but it's time to turn the page and get ready for this next year. Top Canadian fight promotion Aggression MMA is poised to make 2012 its best year yet, and is going to kick off the year in style with a fight card on February 11th. Read More »


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Jaws Unleashed
Title Data
- Genre:
- Action > General
- Developer:
- Appaloosa Interactive
- ESRB Descriptor(s):
- Blood and Gore, Intense Violence
- Number of Players:
- 1 Player
Release Data
Data and credits for this game contributed by LordAndrew and odino.
Know Something We Don't?
You can submit or update game data or submit game credits to help us keep our data up-to-date.


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SPG Instant Awards at The Westin Princeville
Starwood Preferred Guests® (SPG®) can enjoy an array of revitalizing experiences at The Westin Princeville Ocean Resort Villas by converting Starpoints® into Instant Awards. Whether you opt for a Late Check Out or a Romantic Escape under the stars, you've earned it!
If you prefer to apply points to your bill, Starpoints® can be used to pay for hotel services starting at just 375 points for a US$5 credit.
See our Instant Awards menu*.
Speak with a front-desk associate or the hotel concierge for redemption options and details.
*Awards are subject to change without notice.


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FOR IMMEDIATE RELEASE Media Contact:
Jan Frank/for Trinity UCC
Celebrate the Christmas Season with Trinity United Church of Christ
Holiday Services throughout December
Brookfield, WI (December 12, 2011): Trinity United Church of Christ invites you to join us in celebrating the Christmas season. The Trinity holiday services schedule is as follows:
Sunday, December 18, 10:00 a.m.: Trinity's Celebration Singers holiday concert
Saturday, December 24: 4:00 p.m. – A family oriented worship celebrating the birth of Jesus
11:00 p.m. – The Christmas message candlelight service with
Sunday, December 25, 10:00 a.m. – Christmas Day worship including the Christmas message and many holiday music selections.
Each service during the holiday season will be unique and will focus on the Christmas message. Plan on attending one of these joyous and inspirational opportunities and invite family, friends and neighbors to attend these services filled with love and joy at this special time of year.
About Trinity UCC
Located at 4435 North Calhoun Road, between Capitol Drive and Lisbon Road in Brookfield, Trinity UCC is an open and affirming church and welcomes all. The church is wheelchair accessible with an elevator to all levels including listening devices available for use. Trinity invites you to discover a neighborhood church that cares for the world. Whoever you are, wherever you are on life's journey. Visit www.trinitybrookfield.org for more information.
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Welcome to the Quilting Board!
I am not a hand quilter, but I made a batik quilt with a wool batt...quilted like BUTTAH! LOVED it..and will use it again!
Beth in AZ
Innova 22' with Lightning Stitch and Pantovision
Keep away from people who belittle your ambitions. Small people always do that, but the really great make you feel that you too can become great. Mark Twain
I've been buying old, all wool blankets at estate sales and I want to use one for batting, but I haven't gotten around to it. They are light weight, they've been washed, so they shouldn't shrink. I can't wait til I have time to quilt something for myself so I can try it!
I know this sounds like a crazy question, but is the wool batting too warm for Texas weather? Thank you.


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Would you like to save as your currency permanently or for this visit only?
Tryp Murcia Rincon De Pepe
Apostoles, 34, 30001 Murcia, Murcia
0.0 km from
฿ 2,075+
Fox was the only english news. Cnn, bbc, EuroNews would all be better
excellent helpful staff lack of bar / restaurant service and opening times
Excellent location and great value,clean and comfortable room and helpful English speaking staff. Lack of facilities for a 4 star hotel-no gym
Convenience of being able to walk everywhere easily. The breakfast in the room service was a bit confusing! Sat morning none arrived due to nobody picking up our 'order sheet' from our door! Had to say at reception - much better Sun A.M.! Plus, no food served in cafe/bar until 8.30pm - we know Spain eats late! But on this occassion, going to a van morrisson concert for 9pm meant we would have welcomed a decent full service. The reception guy was very good and arranged some basic food - unfortunately, the Pork Baguette eaten by my wife made her very ill during the concert!! It was definitely that as I was ok and had not eaten one! We did say at check out and received 7e off bill!
It was a beautiful hotel with friendly staff and an excellent restaurant. no
I felt comfortable N/A
Excellent value and extremely well placed for the historical quarter of the city.
Good location, great breakfast Parking expensive
quality and comfort very helpful at front of desk
Nice and big room.
Great value for the price
Location Unavailability of lugage helper or driver service after 1200h
The hotel is convenient, comfortable and clean. The hotel staff were all helpful, pleasant and accommodating. The room was fine, and the food was excellent (the buffet breakfast did not disappoint). my car was parked by the hotel staff (overnight parking as an extra cost). I would choose to stay here again.
The staff were very helpful, the rooms were big, clean and bright. We were on the top floor and no smoking. And the decor was lovley There were no tea and coffee facilities.
excellent professionality. a very clean place, very central
The hotel was in an excellent location, very near the city centre and the historic area, just across the river from the Cathedral. The staff were very friendly and helpful and the rooms were very clean and comfortable. I thought the charge for the parking garage was a little expensive. Perhaps a gradually reducing fee every 24 hours could be offered, so the first 24 hours could be charged at full price and then reduce the fee by a day to day basis to a minimum price would be more encouraging.
Good size room & bathroom + terrace, value for money
Level of courtesy and service Very difficult to find. Expensive to park the car in hotel garage.
Nice, clean Difficult to find parkingplace outside hotel. The hotel had a garage a few blocks a away. Not a good solution if you need your car during your stay.
Hotel stuff were very polite. Location of the hotel was also very useful to travel around the city. Noises, noises and noises in the room. Noises from outside and noises from inside, from other rooms.
the service, the cost the bathroom was a bit tight, the elevators quite ugly and I don´t think it deserves to be a 4 star (although the deal I got was great)
The staff were very friendly, helpful and obliging Although touted as being a 4*, this was probably awarded some years ago - the rooms could do with a 'refresh'.
nice building, very central and good breakfast slightly tired paintwork
good location parking difficult
Visiting the sights of the city of Murcia Nothing really.
Central, good restaurants very close, very efficient desk and parking service room small, but no problem for short stay
Location and staff friendliness. Pillows were rather flat and uncomfortable.
close to shops Hard to park outside the hotel on first arrival. The hotel could do with redecoration.
pleasant hotel clean,friendly staff very difficult to find,extremely difficult parking,also very difficult to find entrance to parking
We arrived on a public holiday and the hotel was very quiet. Reception staff were most helpful. The room was clean and well appointed. The location of the hotel is such that it is only minutes walk from the historic centre of Murcia and from a wide selection of places to eat. As with many city centre hotels in Spain, the car park is a nightmare with limited space and many obstructions. A public car park is nearby and would have been a better option. Our room on the first floor overlooked the square at the rear of the hotel and it was not possible to obscure the windows to stop being overlooked. The curtains were heavy and almost blacked out the room.
Location of Hotel to main areas of interest Lack of bar facilities, although coffee bar was open on our last day.
Hotel very nice but very hard to find!!
city trip the hotel need to be renovated, it is quite outdated style, but nice price & services
In the middle of town, especially useful during fiesta parking available, but access a bit difficult
The staff were extremely nice and helpful. The location was just perfect in the center of the city, while it was cozy and quite.
very central staff very poor at english.first room given was very poor,I was moved
location convenient for site seeing and shopping. Staff very helpful and courteous .Although we arrived two hours before check in it was no bother to them and we were allocated a room immediately
Close to shopping we did leave after 1 night as was not in walking distance to the arena as we had been told. Were remoldeling so a bit askew. The person in the room next door took a shower at 4am and I thought I was in a raging waterfall as the wall was very thin apparently.
The location was good near the centre of the city and the hotel staff was friendly. Many of the hotel staff did not speak english, but the were though eager to serve in spite of the common language.
Ideal location for exploring the old town and cathedral . Helpful and friendly staff, bedroom clean and bright Bathroom very small with only a half bath. Walls are very thin, you can hear people next door quite easily
Very polite staff, value for money, nice location opposite park and near the river. Asked to changed rooms 3 times before finding satisfactory room - due to broken air conditioning, broken tap, window locks faulty, curtain rail fell off wall etc. Hotel seems run down.
I would use it again Reception staff were very good
reception and lounge area staff all very helpful, esp Maria for breakfast who remembered my first order and made it every day without me even asking, and the blonde waitress at night. Food and drink very reasonably priced. Lovely location, park across the road and train station 10 mins walk away, bus 15 mins. Excellent supermarkets 5 mins away (turn right at the front door).
The staff were fantastic - we´d had a really difficult journey and they were super accommodating. The price - for all that and 35 euros, couldn´t go wrong. Carpark. States it has private parking which it does, but there´s not way as hard as I tried that we could get the X5 in there. That said the staff reimbursed us the cost of the space and eventually we managed to find a space directly outside the hotel.
Staff were very helpful, spacious clean room and location in relation to city centre very good. Parking is in a secure garage a couple of streets away and you can come and go as you please during your stay. Our hotel faced the gardens - lovely view.
It was central and easy to access. We were only staying one night so it was a flying visit. The staff were helpful and friendly. There was, paided for, parking but its a tight squeeze! The room smelt of smoke and as the room was at the front of the hotel the traffic was audible, although not enough to keep us awake. Breakfast was small and was the only time the staff were not overly helpful
Friendly staff. Modern. Clean. There were no tea/coffee making facilities in the room.
Vey friendly staff, who speaks good English and was very helpful with advising interesting places to visit. Very close to the city centre of Murcia (5 min walk) and all the city attractions.
Kindness of administrators (people at front desk); internet connection; room - tiny, but with taste; the view - (Floridablanca) park.
Lovely hotel with a good location. You couldn't get better for the price.


text: Carey Mulligan Born May 28, 1985 London, England Age 31 SHARE THIS PAGE: Sign Up For Alerts: By signing up, I agree to the Terms and to receive emails from POPSUGAR. Never Miss a Story! SWEET! You're all signed up. 706 photos View All » 43 videos View All »


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|Ligand-Based Molecular Design using Pseudoreceptors
|Fayne, D, 2013
|Computational techniques have successfully been utilized to guide drug design projects–particularly when the target protein involved in progression of the disease is known. The quality and applicability of the model is completely reliant on the biological and chemical data available. If known active compounds exist, their structural and physicochemical features can be utilized to design potentially active novel compounds–ligand-based drug design (LBDD). Knowledge of the 3D structure of the protein enables probing of the binding site and prediction of novel small molecule protein modulators–structure-based drug design (SBDD). Frequently, the protein structure is unknown, so pseudoreceptor modeling can be utilized to infer the protein binding site structure based on complementarity between it and the known active compounds, thereby bridging the realms of LBDD and SBDD. This chapter provides an overview of the technique, highlighting successful example of the methodology exemplifying the various algorithms available.
|ICHEC Project:
|Study of Weak Interactions in Protein-Ligand Models using Quantum Mechanical Calculations to Aid the Design of Novel LXRalpha Modulators.
|in De novo Molecular Design (ed G. Schneider), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527677016.ch9
|pseudoreceptors; SBDD; LBDD; structure–activity relationship; m-QSAR; GPCRs


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Former 4-H leader convicted of custodial interference
MADRAS, Ore. - At the end of a three-day trial, a Jefferson County jury deliberated for about 90 minutes Wednesday and acquitted a former Culver 4-H leader of sex abuse charges.
Steven Stoltz, 67, of Culver, was arrested Dec. 30, accused of sexually abusing a teenage club member.
The jury cleared Stoltz of second- and third-degree sex abuse charges, convicting him only on a charge of second-degree custodial interference, lawyers and prosecutors said.
Stoltz's daughter, Savallah Amber Stoltz, 26, and her husband, John Straight, 25, also were tried and acquitted on the custodial interference charge in the trial, heard by retired Circuit Judge Gary Thompson..
Stoltz is due back in court on May 7th for sentencing on the custodial interference charge.
District Attorney Steve Leriche said the presumptive sentence is up to two years probation and 60 days in jail.
The alleged victim, who claimed Stoltz touched her inappropriately, took the stand and "stated all the facts in a clear fashion," Leriche said, but "you never know what a jury is going to do."
The jury "sifted through a pretty complicated situation and came up with a result that we certainly respect," Leriche said.
Stoltz's attorney, Sean Trimble, later issued the following statement on his behalf:
On April 24, 2013 a Jefferson County Jury acquitted Steven Stoltz of one count of sexual abuse in the second degree and three counts of sexual abuse in the third degree. Steven Stoltz's daughter and her fiancé were acquitted on an unrelated charge of Custodial Interference.
Steven Stoltz, who had been a 4H leader for more than 30 years, appeared at trial with Sean Trimble from the Law Office of Angela Lee.
Mr. Stoltz was supported in the courtroom by friends, family, and many of the 4H students he had mentored over the years.
At the end of a three-day trial the Jury returned their verdicts in about 90 minutes. Mr. Stoltz was convicted of one charge of Custodial Interference, but acquitted on all other counts.
Mr. Stoltz, who served as a combat medic during the Viet Nam conflict in the late 1950s, has a long history of helping people in need. Mr. Stoltz took the stand and told the jury about his efforts to try to help a student who was in crisis, and his subsequent arrest for sexual abuse and custodial interference.
Mr. Stoltz would like to take this opportunity to thank his friends and family for standing beside him and believing in him through this dark time.


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Article Preview
Italy's declaration of war against Germany and her acceptance by the Governments of the United States, Great Britain and Russia as a "cobelligerent" have made a clear-cut break with the past and ended the twilight period of confused loyalties under which the Italians suffered following the armistice.
October 14, 1943
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When Cole Huff decided to transfer from Nevada after two seasons, he didn't expect to find himself in Omaha, but that's where he announced he will end up on Sunday.
"It was great," said Huff of his visit earlier in the week. "The coaches were extremely cool; the players were great. I didn't really know too much about Omaha, it's a little different than what I'm used to, but it's a really nice city."
Instead of places like Omaha and Iowa City, where Huff visited over the weekend, the Altadena, California native pictured himself playing closer to home in the Pac-12 or a similar league. The Wolf Pack, however, placed restrictions on where Huff could settle. Most of the schools Nevada ruled out are located on or near the West Coast.
With his options trimmed for him, the skilled forward searched further inland. Creighton, Iowa, Dayton and Michigan emerged as programs that could offer what he was looking for: more success and more exposure.
"I feel like wherever I end up is going to give me a shot, if I perform the way I'm supposed to perform, to play professionally in the NBA or overseas and make a career out of this," said the sophomore. "Also, I want to go to a winning program. I want to win."
After some displeasure with the way he was being used in Reno, Huff is excited to showcase his full skill set in Omaha.
"Just to expand my role on the team, not necessarily in terms scoring and stuff like that, but just for me to expand my overall game, " Huff answered when asked what originally led him to look elsewhere. "I wanted to get out on the perimeter more. I wanted to show more of my skillset and what I have in my bag of tricks."
Although Huff stands 6-foot-8, he considers himself to be an outside-in player; his 40 percent mark from deep a year ago backs the assessment. Creighton has a recent history of allowing guys with post player size to operate on the perimeter, and that resonated with the Campbell Hall and Team Eleate product.
"There's so much movement and fluidity in how they run their offensive sets," Huff said. "I think it's really great. It's a great way to score points, and it's an attractive way to play for someone like me. It was exciting."


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Combine TABASCO® Bloody Mary Mix, vodka, and TABASCO® Steak Sauce in a large shaker or pitcher with lots of ice. Shake or stir well and pour over ice in tall glasses. Garnish with lemon slices and celery sticks or TABASCO® Spicy Beans, if desired.
Makes 4 servings.
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- Name: Jason Campbell
- E-mail: firstname.lastname@example.com
- Age: 31
- Where: Saskatoon, Canada
- Height: 6'
- Weight: 220 Lbs.
- Years Bodybuilding :18
- Favorite Bodypart: I enjoy training all body parts
- Favorite Exercise: basic movements (deadlifts, squats, bench presses)
- Favorite Supplements: Creatine, Protein, and Vitamin C.
How Did You Get Started?
I was introduced to bodybuilding by my father who still works out today. I was 13 years old and started working out in the high school gym before classes started. I would also workout at lunch time to get more sets in. The next few years I progressed rapidly and I've never quit.
What Workout Plan Worked Best For You?
The best workout plan for me is doing one major body part every 5 days. I currently do the following routine:
- Chest/Biceps
- Legs
- Back/Triceps
- Shoulders
- Day off and repeat.
What Nutrition Plan Has Worked Best For You?
What Supplements Have Given You The Greatest Gains?
Supplements that have given me the greatest gains are creatine and huge amounts of protein.
Why do you love Bodybuilding?
What Are Your Future Bodybuilding Plans?
In 2003 I'm planning on winning the overall for Mr. Saskatchewan. The Canadian Nationals will be in my hometown shortly after that Provincial contest. I would love to compete in that one also. My plans are to compete at the same bodyweight but leaner and harder.
What One Tip Would You Give Other Bodybuilders?
The biggest one tip that I feel other bodybuilders must learn is the importance of nutrition. Bodybuilding is one of the toughest sports because there are so many variables to focus on in order to compete and do well.
Who Are Your Favorite Bodybuilders?
Arnold is the King.


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Router table
My second big project.Needed a table and cheaper to build one plus good practice.
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Very clean, I would love to have something like that. For now I'm stuck with my hand held router.
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Congrats to Sydacia Bunbury
Congratulations are extended to Sydacia Bunbury, who was awarded a Master of Science Degree with distinction in Rehabilitation and Mental Health Counseling from Hofstra University, Long Island, New York in December 2012.
Congratulations are extended to Sydacia Bunbury, who was awarded a Master of Science Degree with distinction in Rehabilitation and Mental Health Counseling from Hofstra University, Long Island, New York in December 2012.
Congratulations to Jennifer Cumberbatch who graduated with a Master of Education Degree from the University of Guyana. We are extremely proud of you.
Congratulations are extended to Mohan Samwaru aka 'Sir Mohan' of Area 'Y' Cummings Lodge on his completion of a Masters Degree in Business Administration (MBA).
Congratulations to our beloved son Richard Brendon Kansinally who graduated with a BSc Degree in Civil Engineering (distinction) We are proud of you.
Guyanese Louise Blenman was recently appointed to the position of Justice of the Appeal Court – Eastern Caribbean Supreme Court, after serving nine years as High Court judge in the Eastern Caribbean Supreme Court.
Zola Efuru Maison graduated with Honours with a Bachelor of Arts Degree in Education and also gained the President's Award at the University of St Maarten, Netherlands Antilles on the 16th June, 2012.
Julian Archer (Jnr.) of 4069 Stevedore Housing Scheme. North Rnimveldt on May 13, 2012, graduatcd.Summa Cum Laudc (GPA3.9 or higher), from Embry-Riddle Aeronautical University (ERAU), Daytona Beach, Florida, with two bachelor degrees: (1) B.Sc.
A Guyanese-born woman was last month sworn in as a judge in the Queens Supreme Court in New York and will be presiding over criminal matters.
Dr. Shane Jagan has graduated with a bachelor's Degree in Dental Surgery in Mumbai, India. He is the son or Dr.
Ronald Cumberbatch was awarded a MSC in Environmental Management in December, 2011 from the Queens University, Northern Ireland. Greetings from your parents Raymond and Jennifer Cumberbatch; your siblings Richard and Rianna; relatives and friends, and your church family Kitty Brethren Assembly.
Congratulations go out to Blayne Javid Bacchus on graduating with his M.B.B.S Degree from the Medical Faculty of the University of Guyana.
The Jamaica Information Service says Principal of the Convent of Mercy Academy (Alpha Academy), Guyanese-born Mackran Singh, is to receive the National Honour of Order of Distinction in the Rank of Officer (OD) on National Heroes Day, October 17, for his contribution to education in Jamaica.
Guyanese Dr. Cary F. Fraser, a historian of international relations, has been appointed the new president of the University of Belize, a release from the university said.
Congratulations to Mrs. Ingrid Griffith, Director of Corporate Services, Guyana Revenue Authority and Housing Scheme, L.B.I. E.C.D. who recently graduated with a Masters Degree in Business Administration from the University of Leicester, UK.
A Guyanese has been appointed the new Chief Justice of Belize. 7newsbelize.com has named Kenneth Benjamin as the island's new head of the High Court and said he is expected to take up his appointment on September 15.


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1.800.555.8260 We're here to help
As a registered member, you'll be able to:
So, i am 17 just got my first car (Jeep Grand Cherokee 2001) i put in brand new alpine speakers and a new head. I just need one more thing to bring it all together...a sub woofer. I've been doing tons and tons of research and decided on the Kicker CompVR 07CVR124. I dont want to spend too much seeing as i dont have all that much to work with but i figured kicker is a reliable source for subs and i got a fairly middle of the road sub. But i have no idea where to start when it comes to looking for an amp, i know that can make or break a sub and i want just the right sub to perfect my audio setup. Please help and give me suggestions
"rap-ish" type music or pop or hip-hop type music is alot better with a ported enclosure.
I recommend this sub in a 2.0 cu.ft. ported enclosure, tuned to 40 hz.
Any of these amps will work. The amps without subsonic filter, you can add 40 hz highpass F-Mods.
I'd go with that Alpine you mentioned. For the amp any of these will do the job. For the box I too would recommend you go with a ported box. I'd look for a box tuned to 30 to 35 Hz. Some of those amps have a subsonic filter (Alpine M50, Sound Ordnance, and the MTX TD 500.1 have it, the rest don't). You will want to set the subsonic filter about 5 Hz below the tuning frequency of the box. You should get the best bang for your buck with that Alpine and any of those amps. Also to re-ask what GLH did, are your speakers amped? If not I would suggest amping those too. If you can tell us what they are we can give you some options to look at. You can get some pretty good 4 channel amps for $150 that will do the trick for the speakers just gotta know what you have. Then all you will need are some amp wiring kits. I recommend Tsunami but that's just cause I like them LOL. You could go with anything really just make sure the wires are pure (oxygen free) copper.
GMC Sonoma, JVC KD-A95BT, 2 Pioneer TS-D601P in doors, 2 Pioneer TS-G4644R in dash, 2 JL W3v2-D2 10 inch subs, Lightning Audio B4.250.2, Soundstream TX1.1300D
What kind of music do you listen to? Kicker Comp VR's really don't do well in ported boxes so I'd advise against that. Look at JL, RF, Diamond Audio, and Alpine. The Comp VR's tend to be "cheaply" made IMO. Not say there bad I just don't think there that good. Kicker's higher end stuff is pretty good but it gets more expensive and you said you want to keep it cheap. If you can give us a budget we can show you some different options that you may like.
i listen to basically anything and everything. I was also looking at the alpine swd 1243d i think its called, that one is about 250 and thats all about all i want to spend on the sub, the amp also no more than 250 so total budget between 500 and 600 should be good. anything in that price range would be wonderful
alright, you seem to know exactly what youre doing so let me rephrase that,
for my budget (600 max) what is a really good sub woofer amp setup (excluding enclosure)
Do you think you want a ported or sealed enclosure ? What music do you listen to MOST ? Are your main Alpine speakers also amped ? You can get a nice amp and sub for $600, but we need to know what type enclosure you will have.
i think i was going to go with sealed, and no at this point i dont have an amp. But mostly rap-ish music i suppose
wow, you just blew my mind, i truly know even less about this stuff than i thought, but ill be sure to check that stuff out. My car doesnt have infinity, does that matter at all ?
I am kinda new at this but if im not mistaken a sealed box has a tighter punch where as a ported will have a more loose and flat sound.
And GLH how many cu. ft would you recommed for a single
kicker l7 15" square sub
The subsonic filter should be as close to the tuning freq as possible.
how many cu. ft would you recommed for a single
kicker l7 15" square sub
how many cu. ft would you recommed for a single
Kicker recommends -
Recommended Sealed Box Volume:
Recommended Vented Box Volume:
spartahockeyMy car doesnt have infinity, does that matter at all ?
Flubba, generally what you ask is true. Sealed has tighter more punchy bass and isn't as loud as ported. Whereas ported is loud and boomy. But it all depends on the design of the box. If a ported box is designed right and built right it will sound better than a sealed any day of the week all across the board. If the box is designed poorly you will still get good sound but only on certain frequencies and that is when you run into flatter sound as you mentioned. You know the old saying, "Location, location, location"? Well when it comes to subs I like to say, "Box, box, box" LOL (just made that up but I like it).
Opps for got to mention that the amps without a subsonic filter you will need one of those F-Mods GLH mentioned.
GLH40 hz highpass F-Mods
Not sure you can actually get a 40 hz highpass F-Mod, but this S/O amp should be about right for that sub anyway, and you come in way under budget -
You would just turn the subsonic filter all the way up to 40 hz, turn the bass boost all the way down, set the lowpass, set the input level (gain), Rock Out.
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German Shepherd Dog Forums (http://www.germanshepherds.com/forum/)
- Training Theory & Methods (http://www.germanshepherds.com/forum/training-theory-methods/)
- - New Training Starting Tomorrow (http://www.germanshepherds.com/forum/training-theory-methods/437297-new-training-starting-tomorrow.html)
New Training Starting Tomorrow
Well, a few weeks ago we had a trainer over and discussed training Cruz and decided to go with him. Now tomorrow is our first session. E-collar is utilized. We'll see how he reacts and I'm as in the dark on this as the dog. So it will be a learning experience for all of us. It is in home or where ever we want it to be. He gave us that option. Any where from home to the dog park. He said it didn't matter. I think we'll start out at home so he doesn't get totally stressed out at first intro to the e-collar. That and it's suppose to rain tomorrow. :rolleyes:
Meanwhile, we have been using a prong for walks only. I think I'm starting to see results. We took about a mile and half walk tonight and he only came out of heel twice and at that, it wasn't much out of heel. He seems to be getting the idea now about just walking past the dogs barking at him. He still can't help but react to a few but it's much toned down compared to where it was.
Well, it's been postponed due to severe weather in the area. Sucks. I was really looking forward to getting started.
Bummer, I know how it feels. Hopefully you can reschedule soon. I've never used an e collar myself so it will be very interesting to follow your and Cruz's progress.
Hope I read that wrong. Training is 'training' and a walk should be a walk. Mixing the two is sucking the life out of both....
Merely not pulling on a loose 6' leash isn't heeling and I think (hope?) that's what you meant.
heeling and how happy/fun it should be:
Loose leash walking:
I love and use the e-collar but only AFTER going to classes and teaching the normal way. What happened in your group classes that you are starting with the e-collar? Same instructor to build on earlier classes?
I think it depends on the persons' definition of "heel". For me, when I'm out walking my dogs, a 'heel' is them being by my side. They don't have to be focused on me and they don't have to maintain an EXACT position but they can't lag or forge too much and they can't stop to sniff.
That being said the only time I make my dogs heel on walks is when we are passing people or bikers or crossing a street. Otherwise they are allowed to roam to the end of the leash and explore (as long as they don't pull).
Since we live on 3 acres the dogs get their exercise in our field. Walks are for fun and exploring.
As far as the training classes go, we've been through two 6 week "normal" training classes. While they were some what effective, they were not effective enough either. We honestly worked with Cruz every night on the commands. We took our first session through Petco. It taught us some basics, but it was cramped with other dogs with their issues and some methods just did not work for us. Leave it and the heel or loose leash walking teaching methods just didn't work. We decided to make a change in trainers and venues. We met with a trainer who himself had two GSD's and it went well for awhile. But Cruze seemed to settle back into the same rut. We did exactly what we were told to do. But it seemed the training was not moving along as it should be. We never got a chance to go back. Between my work and the dogs demeanor, it was risky for just my wife to take him because I was working on the scheduled training days. So we never got to go back. It was during this point, we kept working with him with what we knew and were told to do. But it seemed the more we worked with him, the more confrontational he became at times. Not what I call aggression, but like pecking order type. Also in the back of our heads is the idea that we tried to stay away from other tools, prongs and e-collars, but to train positively. But also both trainer were dead set against using those tools. So we beat or heads against the wall doing what they taught us to do kind of plateau out. It got to the point it was becoming a danger to Cruz, us and the public and possibly other animals. Being this was the reality, neither trainer would consider using other methods or tools, it was time to look in another direction.
So here we are.
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Local contractor Charley Toppino Sons, Inc. may win approval to build a parking lot at Horace O'Bryant School at this morning's School Board meeting in Key West.
"We had three competitive bids for the lot," said Superintendent of Schools Mark Porter. "The Toppino's bid was the lowest, and they're able to complete the project before the end of September. [Toppino's] can do it cheaper, and sooner than anticipated, which is good news on both fronts."
Porter's selection of Toppino was made Monday, with a quoted contract value of $331,997.
School Board Chairman Andy Griffiths on Monday bemoaned the fact that Coastal Construction, which built the school itself, did not express an interest in finishing up the last piece of the puzzle.
"I am confident our policies were followed with respect to all bid awards," Griffiths said. "It is a shame that Coastal Construction did not submit a bid, as they were already stationed on site. They may have been the low bid."
That company had expressed interest in finishing the lot, which needed to be modified from its original design, but later threw in the towel on the project, amidst financial probing from District 3 board member Ed Davidson. At one point, Coastal's unofficial bid offer for the lot was in excess of $700,000.
On Monday, Davidson said the lower Toppino bid proved his point.
"I think it totally dispels the myth that Coastal Construction has been trying to sell to the community that they're Boy Scouts doing us a bunch of favors on HOB," Davidson said. "Remember, a few weeks ago they offered to build the parking lot for us for close to $800,000. They would have turned around and hired the same or similar subcontractors, and charged the taxpayers and the school system a near $500,000 markup. It's pretty simple math. Their charm offensive was short on the charm and long on the offensive, and their outrageous offer shows their true colors."
The other two bidders were Douglas N. Higgins, Inc., of Key West, and DL Porter, of Sarasota, Fla.
Also at today's meeting, board members will vote on whether to authorize Interim Director of Finance Jim Drake to advertise notice of the public budget hearings, tentatively scheduled for July 30, Aug. 27, and Sept. 3, a necessary part of the budgeting process. On Sept. 3, board members will vote on the final budget.
At present, Drake proposes spending $83.4 million on revenues of $84.3 million, compared to expenses of $79.5 million, for the 2013-14 budget, which runs through June 30.
The increased revenues raise the possibility that the teaching members of the United Teachers of Monroe may finally see some financial relief, following years of no raises and furloughs, which board members such as Davidson, Griffiths, and District 4 member John Dick, have simply referred to as "pay cuts." All board members have been vocal in recent months about the need to offer a better deal to educators as soon as finances permit.
"We're still in the process of closing out the books on 2012-13," said Drake. "And negotiations between the district and UTM are still taking place. What we do will depend on what gets negotiated. The bargaining will have an impact on everybody else."
Superintendent Porter was optimistic that the final budget would be well-received.
"The ability to present a balanced budget that does not include budget cuts, given where we've been, is a positive statement about the district, going into the school year."


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Out-of-favour Hull midfielder James Harper has joined npower League One strugglers Wycombe on a one-month loan deal.
Wycombe boss Gary Waddock moved for the 31-year-old, who has played more than 400 games in the top two divisions, as his side attempt to avoid relegation.
Harper has made just two appearances for the Tigers this season and will head to Adams Park on a deal which will expire following the clash with Hartlepool on Saturday February 25.
Waddock said: "I'm delighted to be able to bring somebody of James' quality to the club.
"He's played the majority of his career in the Premier League and in the Championship and you don't achieve that without being a very talented footballer.
"He's got a wealth of experience and knowledge and he's ready to give his all for the cause."
Harper should make his debut in Saturday's trip to Brentford.


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This Long Island boy calls Delmarva home. I have been here with Delmarva Broadcasting
and Cool 101.3 for almost 10 years! I grew up with the Eagles, the Police and Earth
Wind & Fire. I Love the music we play on Cool 101.3. When I'm not in the studio or at
Steve's Seaside Saloon, you can find me on anyone of Delmarva's golf courses seeking
to break 90. Thank you for listening to Cool 101.3. And check this blog for my rants,
entertaining videos and anything else I might think you will enjoy!
The Super Golden Friends
Who has this kind of time?
Comments...from Jeanne Bianco
Maybe Batman and Superman will become 'freinds' in their old age.. Depends on Kryptonian DNA and how long Superman is supposed to 'live'. in Batman Beyond.. in the 90's.. there was an episode where Superman was almost as old looking as batman was.
2012-07-10 16:34:18
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what is the annual multiplier of a yearly increase of 5% due to inflation?
1 Answer | Add Yours
If infaltion is involved, the future value of money is given by:
`F = P(1+i)^-1`
where i is the annual interest
P is the present value
So to get the multiplier,
`(1+i)^-1 = (1+0.05)^-1`
`= 20/21 = 0.9524`
Rounded to decimal places. Remember that, during inflation the value of money decreases while the value of goods increases.
Thus, the answer is `20/21 or 0.9524.`
We've answered 320,050 questions. We can answer yours, too.Ask a question


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Los Angeles officer, suspect each shot after chase (Video)
Los Angeles authorities say a suspect was killed and an officer was wounded during an exchange of gunfire following a high-speed vehicle chase during which police were fired upon several times.
Police Deputy Chief Bob Green says officers started pursuing a gray SUV that was driving recklessly south of downtown at around 2:20 a.m. Monday.
Green says two occupants of the SUV started firing shots at the officers. Following a chase on the 110 Freeway and on surface streets, the SUV crashed and two suspects ran off.
One suspect was found hiding in a dumpster and arrested.
At around 5 a.m. the second suspect engaged officers with a rifle, and officers returned fire. One officer is hospitalized with a gunshot wound to the leg.
Officials say the suspect was pronounced dead at the scene.
Read more at KFI News


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Naturalizer Violette
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Dark Brown Bronze Metallic Foil Nappa Le
The Violette slip-on from Naturalizer® is perfect for those casual days in or out of the office. Available in a variety of leather, fabric or suede uppers with pleated detail at the toe and a metal ring ornament for added appeal. Smooth lining which aids in drawing moisture away for a healthy foot environment. N5 comfort system footbed provides the ultimate in comfort and support all day long. to learn more about the N5 Comfort features. Flexible nonslip outsole is durable and textured for sure footing with each step. Measurements: ; Heel Height: 3 4 in ; Weight: 7 oz ; Product measurements were taken using size 9, width M (B). Please note that measurements may vary by size.


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Date of Stay: June, 2010
Lots of room, but the different camps are pretty far apart, so you pretty much have to drive to the pool or to the store or to the pancake breakfast they have each morning. Good location to see everything in the Hills though without ever having to drive very far. Can only have campfires from 5pm-11pm & they diligently enforce it. So no late night around the fire. Would research other places in the area before staying again.
Date of Stay: June, 2010
Stayed one night on our way to the Black Hills. Great location for families. Lots of activities. Friendly staff. Lots of Blue birds. The Eastern part of the state doesn't know what they're missing. Sites are well maintained, but our neighbor complained about our talking so maybe the sites are a little close together. No phone reception. Would stay again for even longer.


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Natalie Reilly
Published: November 20, 2012 - 1:35PM
For those who think there is no comparison I would like to retort with a quiver of my bottom lip and an emphatic, voice-cracking you don't know what the hell you're talking about. Because Homeland's Carrie Mathison, and Sex and the City's Carrie Bradshaw have more in common than just a first name. Both are self-destructive; both have blurred the boundaries between their personal and professional lives too many times to count and both have harboured an almost compulsive love for men who, because of their own baggage, are just not that into them. And so the question must be asked because we couldn't help but wonder - who is the best Carrie on TV?
Category One: Professionalism at Work
Carrie Bradshaw was passionate about her column in the New York Star, often skipping out early on dates with the girls to meet a deadline. Was this really a sacrifice for work though? Apart from Samantha, who else was really bringing it at brunch? Bradshaw wasn't afraid to take her work home with her, either – in both senses of the phrase. In fact that's where she wrote all of her columns, sometimes at the expense of her love life, (we'll get to that cave of wonders later). Bradshaw even scored a book deal out of her columns – so, to quote the African American limo driver who dropped her home after her launch party 'Guurlfriend, gimme high five!' Actually she didn't say that at all but as one of the three people of colour in the entire series I feel like she might as well have. So Bradshaw was dedicated – we get this. Although there was that one time she got drunk at Vogue. And she did call in sick when she thought she might get fired. And she did briefly give it all up in exchange for Petrovsky in Paris but as Miranda screamed to her at the time she was 'living in a fantasy' and quickly recovered. Overall, a solid effort. 8/10
Carrie Mathison, where do we begin? If crying at work was a KPI, she'd be head of the CIA by now. But Mathison also suffers from bipolar disorder and if this wildly talented officer can't - or won't – take proper care of herself then people are just going to have to deal. So what, if, overcome with sleep deprivation and her own unique brand of nostril-flaring desperation, she made the moves on her mentor, Saul? So WHAT. In case you hadn't sleuthed this out, Mathison is a wunderkind. And if her boundaries are a little, shall we say, elastic, that's too bad. Consider this: if she hadn't disobeyed orders and gone upstairs to search around that apartment in Beirut like an epileptic squirrel feverishly gathering nuts for an imaginary snow storm she never would've found Brody's suicide tape, reopened the case and thus earned a second chance on the job. Mathison dresses professionally too, with most of her sartorial choices resembling a Portman's catalogue, circa 2001. Holla conservative pant suits! Finally, and perhaps most compellingly, she makes fantastic use of post-it notes, (and coloured pens, and cork boards) and nothing says 'I'm ferociously dedicated to administrative tasks' quite like an entire map of them. For all of this, Mathison scores an 8 /10
Category Two: Love Life
Carrie Bradshaw had a powerful connection to post-it notes too, having been dumped on one of them. But her colourful, at times, dramatic love life served dual purposes.
1. It provided her with material, and therefore an income.
2. It distracted her from her real neurosis. Don't pretend you're shocked, Bradshaw played out an almost textbook diagnosis of Love Addiction. Allow me to quote now from the self-help bestseller, Women Who Love Too Much
'By being drawn to people with problems that need fixing, or by being emeshed in situations that are chaotic, uncertain, and emotionally painful you avoid focusing responsibility to yourself'.
Which totally explains her attraction to Jack Berger, Alexander Petrovsky and the irrepressible Mr Big, (with whom she had that affair while he was married to Natasha - a woman who bears more than a passing resemblance to Brody's wife Jessica if ya ask me) It also explains at least some of the motivation behind her friendship with Miranda. I mean, come on! Drawing someone that negative and critical into your friendship circle says a lot about a girl's self esteem.
I digress.
According to the book, 'If female, you are not attracted to men who are kind, stable or interested in you.' Remember episode 14, of Season 4, when Carrie was asked by her gay 'boyfriend', Oliver, to describe her then fiancé, Aidan? The man she would not marry? Her first words, after 'very tall' were 'incredibly kind'.
Incredibly kind.
Incredibly kind.
Yes, I'm repeating those words in order to haunt you with them. I think I've made my point. But just in case - Incredibly kind. Score: 5/10
Carrie Mathison's love life also serves dual purposes. 1. Her - dare we say mutual? Oh, hang it, I'm going with mutual– attraction to terrorist Nicholas Brody gives her the edge in the interrogation room. And by that I mean the bedroom. Oh, I'm joking! No I'm not really.
2. It distracts her from her own neurosis. No, I'm not suddenly classifying a mental illness as a neurosis because Mathison is also a textbook Love Addict. Read that quote about being attracted to people with problems from the book again – this time in a shaky voice with a quivering chin. That won't make it any less or more valid, but it will help you to emotionally connect next episode. Also, there are few things more 'chaotic', 'uncertain' or 'emotionally painful' than being in love with a Marine turned prisoner of war turned al-Qaeda terrorist turned double agent, who is married with kids and may or may not turn rogue and kill everyone – as vice president of the United States. On top of all of this let us not forget the most soul-destroying fact of all: Brody is a full blown ginger.
Score: 4/10
Category three: Connection to Reality
Remember when Berger, terrifically insecure man that he was, made fun of Bradshaw's hat? And she spat back that it was 'fabulous'? Well yeah it was fabulous. Everything she wore was fab-u-lous. Bradshaw's clothes punctuated her life in a way that may be described without hyperbole as breathtaking. But guys, there is no earthly way she could afford any of them. As a writer I feel I can say with some authority that while the job provides a comfortable living, it's not at a Gina Rinehart level. It's true that Bradshaw did score a book deal and put in time at Vogue. But 'four dollars fifty a word at Vogue' while almost nonsensically high is not some secret code for 'I'm in a best friends gang with Marc Jacobs, Sonia Rykiel and Christian Louboutin'. That said, they really seemed to love her at Prada. Score: 6/10
Carrie Mathison suffers from bipolar disorder, which is something that's largely out of her control, (I said largely - she doesn't always take her meds, or take care of herself as she should). But I'm discounting that in the tally for this category. What I will not discount however, are her impulse control issues, of which she has legion. What sort of CIA agent tells a terror suspect during an interrogation she wishes he'd leave his wife and kids for her? Then again, looking at the hot mess the head of the CIA General Petraeus just made for himself, maybe it's a cultural thing over there?
And that's not all! Remember when Mathison ran away to a cabin in the woods for a festival of physical intimacy with Brody - a man she believed to be dangerous? Say what you will about Bradshaw, at least she had the nous to reject the cabin in the woods and everything it represented, (ie, Aidan's core value system – shame about that). Bradshaw knew better though, describing a squirrel as just a rat in a better suit. And when it comes to terror suspects, Mathison would be wise to heed that.
Score: 7/10
Category Four: Ability to conceal real life pregnancy
Bradshaw had the advantage here. Her fashion sense was consistently eccentric so if she wore an Amish-style pinafore to the Hamptons or a shapeless, billowing camisole about town or a bizarre baby doll smock to Atlantic City, everyone could just go 'oh yeah, I get it – edgy!' and not worry about the bump underneath. But Mathison is a different creature because when she's not in those pant suits she's roving about in boot-leg jeans and daggy t-shirts. The solution, at least thus far, has been to pop a bag in front of her, or have her lean forward, (which incidentally made her line 'cease and f—ing desist' all that more powerful). So Bradshaw gets 8/10 for her effort while for Mathison it's a flat 6.
Total marks: Bradshaw 27/40 vs. Mathison: 25/40.
And the winner is – Carrie Bradshaw! Surprised? Angry? Hurt? What do you think?
This story was found at: http://www.dailylife.com.au/news-and-views/dl-culture/who-is-tvs-greatest-carrie-20121119-29lev.html


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Date of Stay: July, 2013
I have stayed here several times in the past. The good is that they are within walking distance of the French Quarter and they have brick and flagstone throughout the park. The bad is that they are under the highway which is very noisy. Also, the wi-fi is useless and the cable TV stations are all snowy. The biggest thing to me is that the staff is rude and obnoxious. It was not worth the money. SInce I took a cab back and forth to the French Quarter, I might as well have stayed in another park for half the price.
Date of Stay: June, 2013
Rate is passport. I needed a park in Gulfport and there are many to choose from. I saw a great review from 2013 with much older reviews with lower numbers. I thought it might be a fake review but I needed a late arrival and they took PA. What a pleasant surprise. Nice park with flat cement pads. New hook ups and all is included. Don't pass this one up when going to Gulfport.
Date of Stay: September, 2012
Fantastic place. All modern utilities. Great shade trees. Friendly staff with cookies.
Date of Stay: September, 2012
WARNING. Getting to the park and getting anywhere from the park is extremely difficult. It is 15 miles past Santa Barbara over and around mountains. Then you exit onto the approach road which is smaller and more difficult to maneuver. And then like Disney World, you reach the entrance only to find another mile of harrowing driving. I have a 26 ft class A diesel with a tow and was very concerned most of the way. Once arriving for our 3 night visit we decided that going back and forth to SB would be too difficult even with just a car, so we forfeited our prepayment through RPI and left. The park seemed nice, but the ride was not.
Date of Stay: November, 2010
We actually were looking for a place around the corner but pulled in here by mistake. One look at the TV monitor of the ocean front plus the super friendly staff made my decision. Since we had a cat, county law will not allow a pet in a rig on the beach. We were parked on the side about two rows back and could see the beach from our location. The people were great and the beach was spotless. Sites and services were great. We stayed an extra night and will return.
Date of Stay: November, 2010
The nightly rate does not allow for 3 figures. It was $120. It was very crowded, and the view was OK. There is a bus that goes by every 90 minutes (not 30) and is not dependable. We got a ride to town and took a cab home. Cabs are about $30, but we took an all day trolley to the furthest point (closest to the park) and paid $10. Some of the people who worked there were nice, but there was a young girl who insisted that Florida lobsters were as big as the ones from Maine (I grew up in Maine) and the only difference was that Florida lobsters come from salt water. I kid you not. Most of the other parks farther away from town charged about the same so I can't complain too much about the price, but at least give me a little more space for the money.
Date of Stay: November, 2010
WOW!! All pavers throughout the park including the rig pad. Clean and comfortable. And only four walking blocks from Bourbon Street. My wife's favorite. Will definitely return next year. By the way, they have an electric gate and a guard all night for security. Nice touch.
Date of Stay: November, 2010
I needed a stopover on our way home from Destin to Houston. I read the reviews and figured for one night how bad could it be, espcecially on Thanksgiving. When I arrived, I could not believe this was the same park that was reviewed. Instead of a "typical" KOA (I was not a member but stayed in two others on this trip), I found a really nice park. The people were friendly and the sites were amazing. All brand new cement pads for a pull though with a brand new box for power, cable, and water. It had two sewers depending on where you parked. They had a new rec room which served free breakfast on the weekends. They had a nice 18 hole putting course with all the extras to make it look exciting. They not only had a pool and a separate hot tub, but a wading pool for the kids. A playground was also near by. Wi-fi was free as well as cable and worked very well. Space was bigger than many others I stayed in, and if we were not in a hurry to get home, I would have stayed another night. This was not your "typical" KOA. I joined KOA based on this location because I plan to return.


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Local Marines may protest Baxter's Walmart Saturday
An area Marine Corps League has waged war on the Baxter Walmart.
It's all likely a misunderstanding that may soon be worked out, but as of Thursday, the Marine Corps League, Heartland Detachment, is planning a peaceful protest and boycott of the Walmart in Baxter Saturday.
Heartland Detachment Commandant Kevin Goedker said Thursday that Walmart officials told the Marines last Friday that they would allow them to collect toy donations for their local "Toys for Kids" program but said then a Walmart manager reneged on that offer on Monday, and instead the superstore would still be collecting toys for the "Toys for Tots" program.
But Walmart general manager Kirk Helmberger told the Dispatch Thursday that Walmart has been collecting toys for the local group all week and he didn't understand why the local Marines would protest his store.
Goedker, also a Brainerd City Council member, said the area Marine Corps League has provided Christmas toys to less fortunate children in the Brainerd lakes area for more than 30 years. The league, in conjunction with The Salvation Army, provides Christmas toys to more than 900 Brainerd area children in more than 400 families. The Heartland Detachment, while supportive of the national Marine Corps "Toys for Tots" program, parted ways with the organization in 1997 because the toys collected locally were being sent to Quanico, Va., and then distributed. Now 100 percent of the toys collected for the local "Toys for Kids" program are distributed to local children, said Jerry Wolters, Heartland Detachment senior vice commandant.
Goedker said last year Walmart stopped allowing them to have a drop box at Walmart as part of a corporate policy, which they understood. This year a Marine noticed a "Toys for Tots" drop box at Walmart and two members of the Heartland Detachment visited with Walmart managers, including Helmberger, last Friday, and explained the situation. Goedker said Walmart staff told them they would change the drop box from "Toys for Tots" to "Toys for Kids" and local volunteers would begin collecting the toys for the "Toys for Kids" program.
But when Wolters went to Walmart Monday to collect toys from the bin he said a Walmart manager, not Helmberger, was rude to him and said that the toys weren't going to go to "Toys for Kids" and the "Toys for Tots" sign remained at the bin.
The exchange rankled the Marines and their volunteers, who maintain 55-60 toy collection bins within the Brainerd area. By Thursday they planned a peaceful protest at the store from 9 a.m. to 2 p.m. Saturday and were asking residents to boycott the store at least on Saturday and to do their shopping at businesses that support the "Toys for Kids" program, including Fleet Farm, Kohl's and Best Buy.
Contacted by the Dispatch Thursday afternoon, Helmberger said he had heard rumblings about 20 minutes before a reporter's call that the Heartland Detachment was planning to protest on Saturday but was unsure why. He said "Toys for Tots" was a national program that Walmart has endorsed and since there isn't a Brainerd "Toys for Tots" program, they decided to collect toys for a "Toys for Tots" program in Crosby, the nearest location. But when Helmberger learned from the Heartland Detachment League last Friday about the local "Toys for Kids" program, he had to clear it with the corporation before making the switch. On Monday another manager told Wolters that Walmart was continuing to collect for "Toys for Tots." Wolters said she told him the toys were going to the "Toys for Tots" program in St. Cloud.
Helmberger said Thursday the bin has been filling up and he wished the "Toys for Kids" volunteers would come pick up the toys. Wolters, contacted again by the Dispatch, said he would head over there and see if he could pick up the toys for the program.
Goedker tried to contact Helmberger later Thursday afternoon but he was gone for the day, Goedker said. So Goedker said he would attempt to contact Helmberger Friday morning to see if he could get an agreement in writing so there were no other misunderstandings. As of Thursday, Goedker said the protest was still being planned until he had a written agreement. The Marines had already been creating protest signs. A Facebook event had been created for the protest.
"That makes me very happy," Goedker said, speaking of the possibility that "Toys for Kids" was once again allowed to collect toys at Walmart.
JODIE TWEED may be reached at firstname.lastname@example.com or 855-5858.


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Froch enjoyed arguably the defining night of his career at the Capital FM Arena on May 27, destroying the previously unbeaten Lucian Bute inside five rounds to become the super-middleweight world champion for a third time.
"I'll just do what I do," said IBF title-holder Froch. "The crowd are already turning up, we've got a packed arena and obviously, Lucian Bute is a different opponent. He was an unbeaten fighter and I was the underdog and I shocked the world that night. People know what to expect and I'm expecting a fantastic night."
Froch takes great pride from having won a world title on three different occasions and has a resume that would be the envy of many a champion.
Over the last four years he has taken on a stellar cast of punchers, starting with Jean Pascal, going on to Jermain Taylor, Andre Dirrell, Mikkel Kessler, Arthur Abraham, Glen Johnson, Andre Ward and ending with Bute.
Kessler and Ward were the only ones to better him - the two losses of his 31-fight career - and rematches with the pair, as well as a second shot at Bute, are being eyed up for 2013. Froch, though, knows none of that can be possible without beating Mack.
"I went through one of the biggest tournaments in the world, the Super Six, where I knew who I was fighting for the next five fights, so you've always got your eye on your next opponent," he added.
"That said, you can't take someone like Yusaf Mack for granted. I am looking at the future, but that's nothing new for me.
"I was in the amateur game for many years, boxed at the top level and had a massive pedigree. I've been a professional for 10 years and nothing is going to faze me.
"I'm not going to be complacent or lackadaisical, to take my eye off Yusaf Mack. I know I've got a job to do and I know that job could be a difficult one tomorrow night."
- More about:
- Boxing


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Nov 21, 2013
Fact Check: Coffman's Allies Falsely Claim He's "Consistent" on Immigration Reform
Congressman Mike Coffman's Washington allies falsely claimed his support of immigration reform has been "consistent" in a comment to the Denver Post this week.
In reality, the only thing consistent about Congressman Coffman's record is his opposition to the bipartisan Senate immigration reform, his support for anti-immigrant zealot Tom Tancredo, his opposition to the DREAM Act, and his vote to start deporting DREAMers again.
Denver Post: "No Colorado House Republican" Support the Senate Immigration Bill. In 2013, the Denver Post reported: "The Senate [immigration] bill, which no Colorado House Republican supports, commits $38 billion on border security — 20,000 new agents, 700 miles of new fencing, expensive technology such as drones and infrared cameras." [Denver Post, 11/10/13]
- Congressman Coffman was Concerned about the Senate Immigration Bill because "Promises Were Not Kept" in 1986 on Border Security. In 2013, Coffman said he was concerned about the Senate Immigration bill, because of the promises not kept surrounding the 1986 immigration reform. "I appreciate the effort that my colleagues in the Senate have made in trying to fix a badly broken immigration system but I'm still concerned because the promises made in the 1986 immigration reform bill on enforcement and border security were not promises kept. I will work for solutions in the House that will provide for the reforms necessary to not only secure our borders but to verify that they remain secure," Coffman said. [Coffman Press Release, 6/27/13]
Congressman Coffman Called Tom Tancredo His "Hero" and Had Served "This Country With Honor and Integrity and Courage." In 2010, while speaking at a Tea Party Express event, Coffman said: "It is a great honor for me to introduce, somebody that is my hero. Somebody that has served this country with honor and integrity and courage. Somebody when the republican establishment in Washington went so and violated the principles that got them elected, who did not stand with them and that is former congressman Tom Tancredo." [Tea Party Express Event, YouTube 3/31/10]
- Colorado Independent: "Coffman Adopted Much the Same Rhetoric and Policy Stances" as Tancredo. In 2013, the Colorado Independent reported: "For years the state's deep-red Sixth District was represented by anti-illegal immigration crusader Tom Tancredo and, when he replaced Tancredo in 2008, Coffman adopted much the same rhetoric and policy stances." [Colorado Independent, 6/06/13]
- Congressman Coffman Praised Tancredo for Killing Republican Immigration Bill. At a campaign rally for Tom Tancredo in 2010, Congressman Coffman said: "When the Republican President of the United States with the Republican leadership with Democrat allies came up with a so-called immigration reform bill that did nothing to secure the borders of the United States and provided amnesty for those who have broken our laws, Tom Tancredo refused to stand with those Republicans. Tom Tancredo is the conservative in this race." [Rally for Tom Tancredo, 10/17/10]
Congressman Coffman Voted to Restart Deporting an Estimated 800,000 DREAM Act Eligible Young People. In 2013, Congressman Coffman voted for an amendment to the 2014 Homeland Security appropriations bill that would prohibit the use of Immigration and Customs Enforcement funds to implement President Obama's June 2012 order that protects the "DREAMers" from deportation—those estimated 800,000 young undocumented immigrants who were brought to the U.S. as children and have since led law-abiding lives. The amendment also prohibits other prosecutorial discretion policies that ensure the agency's immigration enforcement resources are targeted at serious criminals, and not at those who pose no threat to U.S. communities, such as victims of domestic violence and other crimes who come forward to seek protection and identify their abusers. The amendment passed, 224-201. [HR 2217, Vote #208, 6/06/13]
- Said DREAM Act Would be a "Nightmare" for Americans. In 2010, Coffman said that the DREAM Act would be "a nightmare" for Americans. "The Dream Act will be a nightmare for the American people. No doubt, we need immigration reform but the Dream Act is written far too broadly and it will only encourage more illegal immigration, promote chain migration, and will be a magnet for fraud," he said. [Office of Mike Coffman, 12/08/10]


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Finance forte
The future of finance leadership
No one expects the top finance job to be easy. When problems get to the CFO's desk, they are inherently difficult ones — otherwise they would have been addressed earlier.
Nevertheless, as organizations look ahead to an uncertain future, the responsibilities of the role will only increase.
Finance forte provides insight on the future of the CFO role and what current CFOs, aspiring CFOs and boards need to do to keep up.
The study is based on a survey of over 530 Group CFOs and their reports across Europe, the Middle East, India and Africa, as well as a series of in-depth interviews with leading CFOs and future finance leaders from across these regions.
It includes:
- Preparing tomorrow's leaders: nine steps that CFOs can take now
to prepare for the future
- Building the talent pipeline
- Career paths of the EMEIA top 100
At a time when the importance of the CFO role has never been greater, the focus on cultivating the pipeline of future finance leaders needs to catch up with the role's evolution.
The future of the top job
Few jobs today can rival the CFO's role in terms of breadth, influence and profile. Indeed, the CFO is now arguably the most influential role in the organization, particularly at a time when economic uncertainty continues to cause unpredictable demand, capital availability and cash flows.
In light of this role stretch, two-thirds of survey respondents agree that the title "CFO" is inadequate. And while only one-third of respondent organizations currently have a deputy CFO, the majority believe that the increasing complexity of the role will mean that more organizations will appoint one.
Seventy-two percent of respondents agree the breadth and profile of the CFO role makes it a more attractive career aspiration. Yet there are also concerns that the pool of individuals with the appropriate skills and experience to succeed in the position is not sufficient.
Seventy-three percent of respondents agree that very few people in their current finance organization have the broad skills required to succeed as Group CFO.
Those leading CFOs we spoke to do not believe that there is a lack of talented finance professionals. Instead, a number point out that structural changes within the finance function may limit the opportunities for talented candidates to develop the right experience for the top job.
In view of this, they argue that formal identification and development of talent is critical to ensure that there is a strong pipeline of candidates with the right credentials for the role.
Percentage of respondents who either strongly agree or agree with these statements


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Latest Stories
IGN Presents the History of Survival Horror0 Comments
October 30, 2009
About This Game
- Summary
- Specifications
- Features
- Game Editions
In Activision's TIME COMMANDO, you play as tech-wizard Stanley Opar, and it's up to you to travel through time in order to save the planet. A mysterious virus has infected the military's top-secret super computer, causing it to wreak havoc with the very seams of reality. In your adventure to repair the computer, you'll explore nine scenarios including the brutal Stone Age, feudal Japan, and the Wild West. You must do battle with Roman Centurions, cyborgs, and other vicious villains on your quest. Beginning each level unarmed, Stanley must find items to protect himself with. Weapons vary according to the era, so you'll wield everything from primitive clubs to futuristic laser pistols. Collect as many unaffected computer memory chips as you can, find the upload terminal, and repair the compromised computer before time runs out. In TIME COMMANDO you'll solve brain-teasing puzzles, enjoy state-of-the-art 3D graphics and hear stunning, realistic sound. Varying skill settings are available as well for added replay value.
- Supported Functions
- Number Of Players: 1
- 20 levels in 9 worlds over 4 time zones, 45 different weapons, 80 types of enemies, variety of power-ups, and challenging puzzles, 3 skill levels
Time CommandoPublisher: ActivisionRelease Date: January 1, 1997MSRP: 55.99 USD
Help us solve the toughest (or most puzzling) game puzzles and challenges.
Our attempt to answer issues which most commonly occur on IGN's wikis.


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SPIN mag must be pulling a late April fools or smoking some serious A-grade as they have just named dubstep producer Skrillex as one of the best guitarists of all time - although having never actually played guitar under the moniker.
Even though he came in at #100 the chart doesn't use his real name Sonny John Moore - and actually points to the bass drop in "Scary Monsters and Nice Sprites"?
Still not convinced? Take a read of the full spiel;
Look, as far as we know, our asymmetrically coiffed party pal has never held a guitar in his life. But no contemporary musician has a more primal understanding of adrenaline-pumping, pulse-raising, chest-caving bulldozer riffs than dubstep mosh ambassador Skrillex. Somewhere between the unfiltered piston-pumps of nü-metal and the twinkling emocore melodies that weaned him is a gaping sarlacc of yawping melodies and buzzsaw edges. The bass drop to "Scary Monsters and Nice Sprites" might just be this generation's "Smoke on the Water" — look no further than the obscene number of "Skrillex guitar cover" videos on YouTube!
Most Heroic Moment: Korn's "Get Up," even if Munky technically plucked the strings.
Nope... we're not convinced.
Shame on you SPIN.


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Zucchini Frittata
If you don't have any leftover vegetables, you can cook (roast, saute, or steam) 4 cups of your favorite vegetables.
- Prep:
- Total Time:
- Servings: 4
Source: Everyday Food, May 2005
- 4 cups Roasted Zucchini, Onion, and Peppers
- 1 teaspoon olive oil
- 10 large eggs
- 1/2 cup grated Parmesan cheese
- 1 1/2 teaspoons coarse salt
- 1/4 teaspoon ground pepper
Preheat oven to 400 degrees. Brush a 9 1/2-inch deep-dish pie plate with 1 teaspoon olive oil. Drain any liquid from leftover Roasted Zucchini, Onion, and Peppers; place in pie plate.
In a large bowl, beat eggs with grated Parmesan cheese, coarse salt, and ground pepper; pour over vegetables.
Bake until top is golden and center is set, 35 to 40 minutes; cool 5 minutes before serving.


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Oscar bar café is one of the most popular gay bar/cafés in Copenhagen. At Oscar's you can have classic café food, coffee brewed with love, friendly service, cool cocktails and a steady stream of chilled draft beer... Daily happy hour fomr 5 till 9 pm.
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Rated 3.7/5 based on 3 user reviews Edit business info This is your business
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Situated by City Hall Square in central Copenhagen, this elegant hotel features Nordic cuisine, a popular bar and individually designed rooms with modern décor, flat-screen TVs and free WiFi.Information / bookMap
Please inform Strøget Luxury Apartments in advance of your expected arrival time. You can use the Special Requests box when booking, or contact the property directly with the contact details provided in your confirmation.Information / bookMap
Located on the main street of Strøget, this property is 8 minutes' walk from Copenhagen Central Station and 50 metres from City Hall Square.Information / bookMap
Just 3 minutes' walk from Tivoli Gardens in vibrant Copenhagen, this boutique hotel offers free WiFi and designer rooms with a flat-screen TV.Information / bookMap
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A popular and nicely furnished café & bar right at the City Hall Square. Good and inexpensive (by Denmark standards) meals, but not cruisy. The level of service is a bit shaky; sometimes excellent sometimes poor, depending on who's behind the counter. Electro/techno music with DJs on Fri & Sat, and no entrance fee.
Large café at a peaceful corner of Copenhagen's busiest square. The outdoor terrace is nice. The interior is modern, but pleasantly designed. Good wine and tea. It's not really a cruising place, but standing at the bar desk you'll easily get into talk with others. As always in Copenhagen, they will be open and interested if you are a tourist - and slightly more uptight if you are a local.
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If the delivery team members in our health insurance example were being held to the metric that my friend was having imposed, they would most likely create a backlog filled with stories that introduce many of the features identified via the impact mapping exercise. However, because they are acting more from the scope/time/cost paradigm, they are likely to commit to a certain number of stories and strive to get those done. Even if they deliver the web-based claim form first, they may actually be incented to keep delivering functionality. Even though the web-based claim form solved the problem, their actual delivered story points may end up being considerably lower than their forecasted points, especially if they have to provide a forecast at the beginning of a quarter. The same would happen if the delivery team assigned value points to their stories. It's true that this relative valuing may help with making priority decisions, but it wouldn't stop the team from potentially delivering more than they needed to in order to meet the specific metrics. The trouble is those specific metrics are looking at the wrong things. The number of value points I deliver in a quarter doesn't tell me whether I helped a stakeholder solve the problem.
My ScrumMaster friend doesn't work at a health insurance company, but she does work at an organization that has just started adopting agile approaches and is typical of many organizations making the move, in that delivery teams seek to understand and utilize all the practices, but their leaders are reluctant to adopt the mindset shift that is necessary for effective efforts moving forward. They tend to ascribe to the idea that you can't manage what you can't measure, and they seek to equate things in agile approaches based on their existing paradigms of managing scope, time, and cost. Unfortunately, that paradigm does not always lead to the best outcome for the stakeholder.
A focus on value—truly seeking to solve your stakeholder's problems—will lead to the best outcome for the stakeholders. By starting with value as defined by solving your stakeholder's problem and seeking to solve it in the most efficient way possible, it is very likely you will be able to keep within scope, time, and cost constraints much easier than when you start with a laundry list of things that you want to do. Starting with value first is truly the way agile approaches can make things cheaper, faster, and better.
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Festivals often struggle to know how to accommodate families. It's expensive and complicated to provide childcare and offering children's entertainment can often mean running two festivals on the same site: one for adults and one for kids (perhaps with a third stream for youth).
Greenbelt Festival (the UK-based art, faith and justice festival that has been going since 1974) grasped the family nettle this year and decided to do away with their drop-off childcare. In its place they offered a range of children's activities — the idea being this would be more flexible and better serve the needs of family revelers.
I was a little unsure how this would work — having the kids in tow for the four days of the festival would make it hard to get to the music, art and talks I wanted to see. But this being Greenbelt — a yearly experience that has become almost pilgrimage-like for our family — we sucked it up and headed hopefully to the racecourse venue in Cheltenham where it has been for the last ten years.
Like any GeekDad worth his salt, I turned to technology to lighten the load. First I ensured I had enough batteries and chargers (I still find the Pebble hard to beat) to last the time in the tent without being cut off. A wind-up lantern, radio and LED torches for each of us complete the preparations. Continue Reading "Greenbelt Festival Engages Families With High and Low Tech" »