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Drop everything cricket has found fever pitch
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The appeal of bat and ball during an English summer has seldom been greater, reports Sue Mott.
IT HAS been quite simply the greatest costume drama, the greatest reality television and the greatest whodunit seen on our screens.
Dr Who's Daleks were pretty scary but they didn't make grown men retreat behind the sofa for an entire afternoon.
All you could hear beyond the chintz in normally sane households was the clink of beer cans and gibbering.
Cricket wonderful, glorious, nerve-racking cricket has truly come of age. Demanding of intellect and redolent of theatre, this Ashes series has provided the most riveting sporting spectacle of the new century.
Add to that the best loved, most charismatic villain since Darth Vader in Shane Warne and you have the ingredients that have left us all drained and spellbound simultaneously.
At its best, as this has been, cricket seems to combine the work of Hollywood scriptwriters and Shakespearean actors.
All that we needed to make the final act of the fourth Test more desperate was the injured Simon Jones to score the winning run by limping the length of the wicket. The hopalong tailender was not called upon but the rest was quite terrifyingly thrilling enough.
A perfectly sensible primary school teacher in her 40s telephoned me at one point to report that if England lost, she was going to hang herself from her apple tree. One might have alerted the Samaritans in such circumstances but that would have meant missing the next ball. She'd have to take her chances.
The key to the series has been its closeness. England is the better team, but the belligerence of the Australians is majestic.
Who could have had any idea how this series would change the way we view the sport? With all due respect to Dr Who, there has been no program this year so compelling. It wipes the bin-worthy bilge of Big Brother off the face of the planet.
The whiteness of the protagonists' outfits hasn't hurt things at all. We can still tell them apart. Warne, with his earrings the size of chicken nuggets and that dangerous little smile playing about his lips, is fully differentiated from his captain Ricky Ponting.
He is a man pouting with a succession of disappointments, fined 75 per cent of his match fee for spitting expletives at the manner of his dismissal and yet big enough to be gracious (eventually) in defeat after Trent Bridge.
Warne has, from first to last, been magnificent, running his hand through his laser-treated hair as every ball has nipped, tucked and dived around the flailing bats of opponents.
It took a while for this cricketing summer to begin and now we don't want it to end. The battle between the sides could not be more ferocious and yet the comradeship between sportsmen could not be more apparent.
This is cricket's finest hour, certainly to a generation that cannot remember Don Bradman, nor even Ian Botham. This is our children's introduction to cricket and if this doesn't spawn a mass rush to pavilions up and down England and Australia, nothing will.
Cricketers may have played finer innings, bowlers may have bowled better balls, batsmen may have conjured truer shots but for sheer, knife-in-the-gut spectacle, we have never seen anything like it.
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With coupons on your phone, it doesn't matter where you left the scissors
November 23rd, 2009 | Published in Google Earth
We know that coupons are a great way for local businesses to drive customers to their stores - that's why we created the option for businesses to add coupons to their Google Local Business Center listing back in 2007. Now, as the holiday shopping season kicks off, we've upgraded the ways that customers can find your coupons.
First up, with more and more people using their mobile devices to find local businesses, we've added a new option for Local Business Center users in the US to display their coupons on mobile devices. Additionally, we've made it simpler to find and print coupons from your desktop, so now it's easy to get discounts wherever you are.
Coupons on a mobile device
If you add a new coupon to your business listing in Local Business Center, by default it will now be available on mobile devices. To make your existing coupons available on mobile, edit them and check the box for Mobile Distribution, as shown here:
When users pull up your business listing on their mobile phone, they'll see a section that lists the available coupons. They can then click to find a specially-formated page which shows all the coupon details they need for redeeming it. Now even when customers are on the go, they can see all the great values and offers available from your business.
Improved interface for desktops
We've also overhauled the printable pages that people visit from a business' Place Page. Now you can be confident that every Google coupon customers bring to your store will look the same, helping you and your staff easily recognize and redeem them. In addition to the re-design, we've made sure that the coupons print out correctly and consistently across all major browsers and operating systems.
To create a coupon now or to claim your business with Local Business Center for the first time, visit google.com/lbc.
Posted by David Armstrong, Software Engineer
Posted by David Armstrong, Software Engineer

subset: commoncrawl


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2008-11-14 / School News
After School Program Tours Jamaica Bay Wildlife Refuge
Students from Rockaway Waterfront Alliance's Environmentor After School Program recently met with Don Riepe of the American Littoral Society to take a tour of the Jamaica Bay Wildlife Refuge.
Riepe, a former national parks manager of the refuge, gave the students the opportunity to experience firsthand some of the native plants and shoreline habitat which they have been studying as part of their work to create the Arverne East Dune Preserve on the Rockaway peninsula. In the fall season, the plants and berries vary in an array of golden colors.


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May the Shwartz be with you brother!
This is a discussion on ...I just don't wear the helmet... within the Off Topic & Humor Discussion forums, part of the The Back Porch category; I'm going to take the day off tomorrow and go see a matinee of Star Wars while all of the children are still in school. ...
I'm going to take the day off tomorrow and go see a matinee of Star Wars while all of the children are still in school. I've got some really odd feelings about these movies.
I saw the first one, now called Episode IV when I was 26 years old. My Dad and I were always fighting about my future. I wanted to pursue my own agenda, while he talked about me joining in a business venture with him.
During the next major portion of my life, I was on my way back from a very bitter period. I was seeking redemption, wondering if I deserved it. When Luke took the helmet off of his Father, there was just a battered old man, working his way back.
An odd journey. When I was eighth grade, I had thoughts of becoming a priest. Less than two years later I was on a motorcycle. Then I wondered where I was going, jumping jobs, and now somewhat at peace.
And while I enjoy Star Wars, I'm always somewhat pained by Darth Vader, a character portraying a person of my age, simply in a story told backwards.
The search for spirituality, the impatience, the anger, the self destruction, the remorse and the redemption often hit very close to home. Even all of the black clothing we wear becomes a self-effacing joke. And in one of life's painful ironies, we sometimes sound the same breathing.
And so tomorrow, over a bowl of popcorn, I go to witness the destruction of a twenty year old boy, twisted by politics and impatience, lashing out in anger for all of the wrong reasons. I saw a clip of Natalie Portman crying, and I also remember my own wife crying for many of the same reasons.
I always wore mirrored sunglasses when I rode, and I still do from force of habit. No one gets to see inside.
But like I said, I just don't wear the helmet.
May the Shwartz be with you brother!
Kimber Ultra CDP Elite STS II
A gun is a tool...the real weapon is between your ears!
Today while all the children were in school I was in school with them.
I received a telephone call in my conference period on my personal line.
On the other end a woman yelled at me in Spanish. Something about a chicken. I know enough Spanish to know the word for a chicken.
"I'm sorry ma'am can I help you?"
Something about money and a chicken. Then I responded very slowly, trying to pronounce each word as correctly as I could.
"Senora, lo siento pero no hablo espanol. Hablo ingles solamente. Que necesita?"
And then she hung up, right as Anakin killed Jar Jar.
Oh, thank you! Thank you, thank you, THANK YOU!Originally Posted by Euclidean
I was thinking about waiting for that to come out on video. Now I think I'll go to the matinee just to watch that little treat!
lol I was joking. I haven't seen the movie.
Mrshonts and I, along with a handful of pals, went to the midnight premiere. We waited in line since around 7:30pm. It was fun seeing all the costumed people, including the guy who spraypainted a garbage can to look like R2D2.
I have a lot to say about this movie, but I'll keep it short so I don't ramble on. Lots of meat and no potatoes. A daytime soap opera has better dialogue than the stuff Anakin and Padme dribbled out. I almost started laughing. And neither one can act, but I guess it pays to be pretty (Insert Toecutter's "but should you lose the pretty face.." quote here). Lots of lightsaber action. Christoper Lee has always scared me. Choppy editing. R2D2's moves were too over the top. Yoda, fighting liked a crazed gerbil, saved the movie. Chewbacca cameo. Jar Jar cameo at the very end; too bad he doesn't die. I'm a big fan of the original three movies. Did I mention I'm irritated at Lucas' edits of the old movies? HAN SHOT FIRST!
"Americans have the will to resist because you have weapons. If you don't have a gun, freedom of speech has no power." - Yoshimi Ishikawa
I saw the movie this afternoon, and then worked for a few hours. It took me a few hours to reflect.
One of these days I'm going to find a way to scan some old black and white pictures I've kept, and post some here. What got me thinking about those photos was the stark contrast in the portraits of Hayden Christensen in just a few short years. He really did look innocent.
For me, the action of the movie was just subtext to advance the plot. The story of people failing and struggling has been where I place my focus.
For example, as the last of 'Anakin' is laid out on the physician's table, I remember my own examination for a seriously broken neck. The thought of your life turning, forever changed, within a few minutes. You cannot live through a "flex extention" test and not feel deep pangs when similar scenes are depicted, no matter how theatric.
And I must admit, that after the surgeries I've had, I try and shake the cobwebs and look for my wife. It was poignant to hear James Earl Jones' voice ask about Padme in such a fragile timber.
I had seen an interview with Lucas who said the story is based on recurrent themes in literature. Stories of pupil and teacher, and of father and son. I also believe that you have to be of a 'reflective' age to feel the parallels as well as draw them.
But let's end on a humorous note. I have asthma and a touch of sleep apnia, especially when I've been on my back for longer periods.
My wife was awakened one night when one of the pups had barked, and then tried to get under her covers. As she came to, she says she listened to an exact rendition of Darth Vader taking several breaths beside her. Even dogs fear The Dark Lord of Sith.
I now offer a 'plasma charge' at some very reasonable prices in my sharpening business. Pardon a few deep breaths.
Coimhéad fearg fhear na foighde; Beware the anger of a patient man.
Silly, Bumper? Look at it from the dog's point of view.
The breathing, the clanking of the water softener late at night. And the fact that Neko and Sasha are from the same litter, and I often ask, "Where is your sister?"
Heck, even I thought that their initial reluctance to use the newspaper was a 'rebel alliance.'
I just never got into the Star Wars thing or gone that overboard on any other movie. I mean, hell, I think that Lord of the Rings trilogy is one of the best movies ever made, but I have never dressed up like Frodo.
I did get prodded into going to one of the Star Wars shows a few years back on opening night and felt like I had been transported into a freakshow (sorry, Freakshow) with all of the people dressed up and acting insane. I always wondered if they really were. Another time I got pretty drunk and went to a Rocky Horror Picture Show. I didn't have to wonder whether they were insane, they were....
Coimhéad fearg fhear na foighde; Beware the anger of a patient man.
The closest I've ever become to being a movie freak is that I've long desired to recreate the shotgun used in the Evil Dead series for no good reason whatsoever.
Oh My Bumper!! You too saw the Rocky Horror Picture Show?? I remember the crowds in Boston...........EVERY Saturday night.....the same people showed up! I can remember the line "Great Scott!" and tons of toilet paper would fly throughout the theater! Thye knew the lines by heart. Including the gentleman when seen narrating the show on screen the shouted......"He has NO NECK!" LMAO
There are movies that seem to speak to the person you are--or from which you are trying to change.
For example, every few years I watch a movie called "All That Jazz." Now, granted, I have no musical talent, but I did lead the same lifestyle. I did come face to face with my own mortality and I did have a lot of messy relationships.
I started watching the moving as a young man, and I was surprised on how the movie and I matured together. Different aspects meant different things to me as I aged.
Same with Star Wars. As a younger man, I was Luke, angry with my Dad and anxious to get on the road on live my own life. Then later in life, after being knocked down a few times, I was Vader; a little more tired, not so eager to view the world in absolutes.
And, of course, the spirituality always keeping in check the anger and lust.
Yes, these movies are clunky with dialog poorly written, acted and felt. But there is a reason I think they are popular. Just about any movie now has CGI. However, everyone has a Father, or a son or a life going in a direction we had not anticipated. We have setbacks, injuries and we make deals with the Devil.
You fight all of these things, either to beat them or just hide them. Then you get sick of the mask, or the mask crumbles. I do not view Vader as the villian, if I ever did. I view him simply as the "every man" character, swept away in the politics and heartbreak of that time in his life.


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We offer a full range of classes to fit your child's age & development
Our facility offers free VPK. Call us for details.
We believe that every child is unique and will grow at his or her own pace. Our teachers spend time nurturing children's strengths and encouraging them to reach new heights.
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The best method for providing overcurrent protection for most circuits is to use a circuit breaker that combines overcurrent protection with short-circuit and ground-fault protection. However, this isn't usually the best choice for motors. With rare exceptions, the best method for providing overcurrent protection in these cases is to separate the overload protection devices from the short-circuit
Discuss this Article 4
Are any of the following statements true for a 1-hp, 120V motor, nameplate current rating of 14A?
Please take a look at some incorrection
1. 1-hp@ 120v motor exists only as DC type (see T.430.27) FLC 9.5A
but you use 1-hp AC current value
2. 1-hp single phase AC motor is related to 115V, not 120V (.430.28) FLC 16A
3.THHN cable relates to 90C group (HH means 90C)
why did you use 60C column to determine wire size? There is no THHN @60C cable.
4. Never said that we have to use in this particular task inverse time breaker,not instaneous trip type,but you choose 250% rate. Why? By common sense?
Per my opinion, this example given in very sloppy (I would say unfair) state and,if you,God forbid, get it diring computer based electrical exam,you will definitely click the wrong answer even your calculation is perfecly correct.
Thanks. Andrew-Electrician
I do not agree with the following statement:
"You must size the short-circuit ground-fault protection device from 150% to 300% of the motor FLC [Table 430.52]."
Table 430.52 gives the MAXIMUM rating meaning that the short-circuit protection device can be sized smaller. Now its true that sizing it too small can prevent the motor from starting but that is not really a safety issue and therefore not a concern of the NEC.
Thoughts anyone?
Now I calculate CB & cable after we get FLC from tables. For example, if I have HP and voltage of 3-phase motor I can go to Table 430.250 to get FLC.
My question:
Now I have 3-phase motor, 5 hp and 380V on nameplate, but this voltage value is not in Table 430.250.
How can I determine FLC?


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Tag: hand
8 Easy but Awesome Beginner Tipswritten by nadinadu on 2011-09-16 #gear #tutorials
Anyone who has spent enough time in the Lomo Society will have a faint idea of some popular tricks people like to do which give you great results! So this Tipster is for all the Lomo-Beginners out there! (Not saying that I am in any way an expert on these! I just happened to see other people doing them and felt like spreading the idea for the newbies!)31 184 Share Tweet
How about a Hand?written by quaisoir on 2010-04-20 #gear #tutorials
Make a paper cut-out of a hand and have fun with it!21 24 Share Tweet
Analogue for a Day: Refreshing My Handwriting!written by shuttersentinel17 on 2012-04-26
My self-imposed handwriting refresher course: exchange the keyboard for a pen and paper! As a disclaimer beforehand, I still know how to write using a pen!5 31 Share Tweet
Gallery of Guilty Pleasures: Double that Hand, Darlingwritten by mayeemayee on 2013-04-07
Sometimes, there are things in life we just can't stop doing. Sometimes these are things we don't want or actions we know have been done too many times but still, jump in the bandwagon that eventually turns into a guilty pleasure.9 23 Share Tweet
The Many Emotions of My Left Hand, Caught in Photoswritten by modern_nmt on 2013-04-15
Do you believe that our left hand can tell emotions? Sometimes, when we're sad, happy, or feeling anything else, our left hand can tell everything.3 7 Share Tweet
How to develop by hand your Instant Miniwritten by jodidopanki on 2011-05-26 #gear #tutorials
After having some little problems with my instant photos, I decided to play with a Fuji Instax film cartridge. This is what happens when you develop by hand this tiny instant photos.1 8 Share Tweet
A Lomographic Carnivalwritten by sye on 2012-04-16 #gear #tutorials
We attend different parties each month. In December: Christmas parties, in January: New Year's parties, and on February: the Carnival!1 8 Share Tweet
Your Hand: The always-ready mask / splitzer for double exposureswritten by mythguy9 on 2011-06-15 #gear #tutorials
Ever wanted to double or multi-expose your shoot but left your mask or splitzer somewhere else? Now here a quick tip about the cheapest (virtually zero-cost!) way to deal with the situation.4 Share Tweet
Twosday Tuesday: Reach for the Lightwritten by cheeo on 2014-09-09
Is it serendipity or shared genius? You decide. This week's Twosday Tuesday piece captures two Lomographers' photographic musings as they reach for the light.2 Share Tweet


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Friedrich Schiller University Jena (FSU) (German: Friedrich-Schiller-Universität Jena, colloquially Uni Jena), is a public research university located in Jena, Thuringia, Germany.
The university was established in 1558 and is counted among the ten oldest universities in Germany. It is affiliated with 6 Nobel Prize winners, most recently in 2000 when Jena graduate Herbert Kroemer won the Nobel Prize for physics. It was renamed after the writer Friedrich Schiller who was teaching as professor of history when Jena attracted some of the most influential minds at the turn of the 19th century. With Karl Leonhard Reinhold, Johann Gottlieb Fichte, G. W. F. Hegel, F. W. J. Schelling and Friedrich von Schlegel on its teaching staff, the university has been at the centre of the emergence of German idealism and early Romanticism.
As of 2009, the university has around 21,000 students enrolled and 340 professors. Its current rector, Klaus Dicke(de), is the 317th rector in the history of the university.
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Home > National News > Article
A Victorian Government audit has found that the state's leading insurance agent engaged in misleading conduct in processing workers' compensation claims.
Three senior executives have left insurance company CGU after the Victorian WorkCover Authority audit.
The conduct identified could have boosted incentive payments to CGU or reduced penalties for poor performance under the company's $40 million workers' compensation contract with the Government.
The audit revealed irregularities in claims files, which showed the company had given wrong information to WorkCover. CGU controls about 35 per cent of Victoria's workers' compensation business.
The revelations will be the subject of a major report to the VWA board this month. The board may consider further action against CGU.
The audit also identified another authorised corporate agent, Cambridge, which has refused to talk to The Age. Four other insurance agents are licensed to process compensation in Victoria.
A group of key union workers' compensation officers, known as CARE Group, has referred the discoveries to WorkCover Minister Rob Hulls, saying the "irregularities" were viewed with deep concern. The group's co-ordinator, Geoff Lewin, has demanded that Mr Hulls refer the discrepancies to the Auditor-General for investigation.
"We believe the irregularities would have had an impact upon the cost of the scheme if they remained undiscovered, which is why we want an investigation," he said. The WorkCover audit, which is still not complete, is monitoring the agents' incentive schemes, which are designed to rehabilitate workers and return them quickly to the workforce.
WorkCover claimed yesterday the CGU audit issues did not affect service to injured workers, saying the "inconsistencies" were confined to only two of the six registered agents.
But the Victorian Chamber of Commerce and Industry raised doubts about the effectiveness of the Government's incentive-based scheme.
Occupational health and safety manager John Smith said the former CGU executives appeared to have acted to improve the company's position by putting in place measures to boost incentive payments that WorkCover made to the company for settling claims.
"I think they (former CGU executives) have looked at the system and said how can we make this work for the company," Mr Smith said.
WorkCover spokeswoman Mandy Frostick said the file inconsistencies related to "procedural matters". She said the irregularities related to CGU giving false information to WorkCover. The information was linked to incentive payments.
Wayne Burns, a spokesman for the IAG insurance group, which owns CGU, said the company had done an extensive audit of its claims files after being advised of inconsistencies.
"It did show that some documents had been altered," he said. "It went to how we carried out our claims. We co-operated fully and we now have new processes in place to make sure this doesn't happen again. But as a result we have three people who are no longer with us."
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United Way 5K and Fitness Walk
Your data is secure. Click here to learn more.
Click here for the overall 5K results.
Click here for the 5K age group results.
Click here for the corporate team results.
Click here to go to the one mile youth run page.
Since 1994, United Way 5K Run and Fitness Walk has been a part of Paducah's BBQ on the River. More than 500 runners and walkers come from across the U.S. to participate in the race where we utilize a chip timing system to produce accurate results. This is a wonderful event that promotes health, fitness and a fun time for everyone; serious runners, kids, corporate teams, running clubs, entire families, or community groups can join in. Since 2001, the race has also offered a 1-mile Youth Run to children ages 12 and under. Day of Race Registration will open at 7:30am and close at 8:30am. The 5K race will begin at 9am and the one mile youth run will take place following the 5K.
Pre-registration for the 5K is $25. Day of Race Registration for the 5K is $35.
Pre-register an adult for the 5K and you can pre-register a child (12 or under) for the one mile youth run for free! Please note this applies to pre-registration only. You cannot redeem a free child registration the day of the event.
Pre-registration for a child for the one mile youth run is $10. Day of Race Registration for the one mile youth run is $15.
The race course for the 5K and the 1-mile Youth Run begins in downtown Paducah at the Paducah Bank main branch, located at 555 Jefferson Street.
5K Corporate Team Division:
- Any corporation, profit or non-profit, may participate
- Both full-time & part-time employees may participate
- 3 employees are required per team (no more, no less)
- All 3 participants must be employed by the same employer
- Multiple teams per employer are allowed and encouraged to register
**Pre-race packet pick up will be on Friday, September 23 from 4:30pm-7pm at Paducah Power, located at 1500 Broadway in downtown Paducah.
Thanks to our 2016 Title Sponsor
Thanks to our 2016 Youth Run Sponsor
Thank you to our 2016 Co-Sponsors
555 Jefferson Street
Paducah, KY 42001
United States
Email: email@example.com
|Event Fee(s)
|United Way 5K Advanced Registration
|$ 25.00
|1-Mile Youth Run Advanced Registration
|$ 10.00


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Hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and hepatitis C virus (HCV)-HCC are the main indications for liver transplantation. We compared differences in survival outcomes between these two conditions.
Methods and Findings
The China Liver Transplant Registry (CLTR) contains data collated from all transplants performed in 86 liver transplantation centers across China. We analyzed CLTR data from January 1999 to December 2010. In all, 7,658 patients (7,162 with HBV-HCC and 496 with HCV-HCC) were included in this study. Clinical characteristics were compared between the HBV-HCC and HCV-HCC groups; Kaplan–Meier analysis was used to calculate the overall, tumor-free and hepatitis-free survival rates. The 1-year, 3-year and 5-year overall survival was significantly higher in HBV-HCC recipients than in HCV-HCC recipients (76.65%, 56.61% and 49.10% vs. 64.59%, 42.78% and 39.20%, respectively; P<0.001). The corresponding tumor-free survival rates (63.55%, 47.37%, 40.99% vs. 56.84%, 38.04%, 35.66%, respectively) and hepatitis-free survival rates (75.49%, 54.84%, 47.34% vs. 63.87%, 42.15%, 39.33%, respectively) were both superior in HBV-HCC recipients (both P<0.001). Multivariate analyses identified hepatitis, preoperative alpha-fetoprotein (AFP) level, size of largest tumor, number of tumor nodules, TNM stage, vascular invasion and preoperative model for end-stage liver disease (MELD) score as independent predictors of overall, tumor-free and hepatitis-free survival.
Citation: Hu Z, Zhou J, Wang H, Zhang M, Li S, Huang Y, et al. (2013) Survival in Liver Transplant Recipients with Hepatitis B- or Hepatitis C-Associated Hepatocellular Carcinoma: The Chinese Experience from 1999 to 2010. PLoS ONE 8(4): e61620. https://doi.org/10.1371/journal.pone.0061620
Editor: James Fung, The University of Hong Kong, Hong Kong
Received: May 19, 2012; Accepted: March 15, 2013; Published: April 16, 2013
Copyright: © 2013 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the National Natural Science Foundation of China [grant number 31140004]; the National Basic Research Program of China (973 Program) [grant number 2009CB522403]; and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China [grant number 81121002]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Hepatocellular carcinoma (HCC) resulting from chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection is an important cause of liver disease worldwide [1], [2]. An estimated 400 million people in the world have HBV infection [3]. In China, HBV infection is the most important risk factor for the development of HCC. Approximately, 130 million people are HBV carriers [4], [5]. In addition, China has the highest incidence of HCC and accounts for 55% of all newly diagnosed HCC cases in the world [6]. HCV infects approximately 170 million individuals worldwide [7]. With an estimated prevalence of 1%–1.9% (approximately 13 million patients), China alone has more patients with HCV infection than all of Europe or the Americas [8]. Patients with hepatitis C are at risk of developing HCC at a rate of approximately 1%–3% per year [9].
Liver transplantation is a life-saving therapy for HBV-infected and HCV-infected patients with HCC. However, recurrence of HCC and hepatitis after liver transplantation has long been recognized in both hepatitis B and hepatitis C patients, which makes these infections the most important risk factors that determine prognosis and outcome after liver transplantation [10], [11], [12], [13].
The differences between HBV and HCV infections may result in different outcomes after liver transplantation. There are currently a number of studies that have been published regarding the different clinical characteristics of HBV-associated HCC (HBV-HCC) and HCV-associated HCC (HCV-HCC) [14], [15], [16], [17] and the transplantation outcomes for each condition [11], [12], [18], [19]. However, few studies have directly compared the survival outcomes of HBV-HCC and HCV-HCC or determined the impact of differences in HCC and/or hepatitis recurrence between HBV-HCC and HCV-HCC patients on overall survival. Given the current liver donor deficit, it seems important to understand the differences in the survival profiles of recipients with HBV-HCC and HCV-HCC, in order to better allocate liver grafts and to maximally benefit patients awaiting liver transplants.
We therefore analyzed the China Liver Transplant Registry (CLTR) data to evaluate clinical characteristics and compare survival rates after liver transplantation between recipients with HBV-HCC and those with HCV-HCC.
Materials and Methods
Ethics Statement
Ethical approval was obtained from Committee of Ethics in Biomedical Research of Zhejiang University. Written informed consent was obtained from all participants.
The research design was hospital-based and retrospective, with all cases being well evaluated. The research was approved by the CLTR (http://www.cltr.org/), which was initiated by the joint effort of the 20 most reputable liver transplant centers across the country in February 2005 and authorized as the only national liver transplant registry in Mainland China by the Ministry of Health in May 2008. Its database warehouse is administered by Center of Study for Liver Disease, Queen Mary Hospital, Department of Surgery, The University of Hong Kong.
The aim of this study was to compare the clinical characteristics and survival rates of HBV-HCC and HCV-HCC patients after liver transplantation in order to provide useful evidence for donor liver allocation.
In all, 18,860 cases of liver transplantation were collected by the CLTR between January 1999 and December 2010 from 86 liver transplantation centers across China. The inclusion criteria for our study were as follows.
- HCC: Pediatric liver transplantation patients and those who had undergone retransplantation, combined transplantation or liver transplantation for acute/fulminant liver failure were excluded. Patients with symptomatic HCC, pre-transplant HCC patients (or HCC patients waiting for liver transplantation) without symptoms, patients with HCC recurrence after primary liver resection, patients who underwent liver transplantation after interventional therapy for HCC, patients with other undefined tumors who underwent radiofrequency ablation (RFA) or transcatheter arterial chemoembolization (TACE) or other interventional therapies for HCC were included.
- Type of liver transplantation: Both whole cadaveric donor liver transplant recipients and living donor liver transplant recipients were included.
- Hepatitis B: Recipients diagnosed with "hepatitis B" according to etiology, and/or recipients who tested positive for "hepatitis B surface antigen (HBsAg)" and/or for "HBV-DNA on branched DNA (bDNA)" and/or "polymerase chain reaction (PCR)" assays were included.
- Hepatitis C: recipients diagnosed with hepatitis C according to etiology were included.
- HCC recurrence: Post-transplant patients with records for definite mentions of HCC recurrence or the date of first detection of HCC recurrence, and/or who underwent treatments for intra- and/or extrahepatic recurrence (intra-abdominal, chest recurrence and others) were included.
- Hepatitis recurrence: The judgment of hepatitis B recurrence was on the basis of the following parameters included in the CLTR database during postoperative follow-up: a) histological change was marked with hepatitis B recurrence during postoperative follow-up; b) postoperative serological status changed from HBsAg or HBV-DNA (bDNA or PCR assay) negative to positive or there was the date of the transition. Post-transplant patients who were diagnosed with hepatitis C recurrence based on post-transplant liver biopsy were also included.
Using the above criteria, we excluded 11,202 patients from this study. We analyzed data pertaining to the remaining 7,658 patients who underwent liver transplantation for HBV-HCC or HCV-HCC (Fig. 1).
The 7,658 patients were divided into two groups according to the type of viral infection: the HBV-HCC group with 7,162 patients and the HCV-HCC group with 496 patients.
We compared the following clinical parameters between the two groups: age, gender, vascular invasion, downstaging, number of tumor nodules, size of largest tumor nodule, sum of tumor diameters and preoperative alpha fetoprotein (AFP) level. In addition, we compared the frequency of major postoperative complications between the two groups, including biliary and vascular complications, postoperative infections, renal failure and graft dysfunction.
The antiviral therapeutic schedules for hepatitis recurrence were mainly judged by the date of commencement of antiviral therapy with lamivudine, entecavir, adefovir, or telbivudine in the "postoperative data-recipient hepatitis serological status" column in the CLTR database. The above four antiviral drugs are all used to prevent hepatitis B. As for postoperative hepatitis C antiviral prevention programs, CLTR database does not include related drugs in a short time.
Patient survival was assessed using the Hangzhou criteria, which are as follows: patients without macrovascular invasion who have one of the two following items: (a) total tumor diameter less than or equal to 8 cm; (b) total tumor diameter more than 8 cm, with histopathologic grade I or II and preoperative AFP level less than or equal to 400 ng/ml, simultaneously. We have previously shown that the Hangzhou criteria are similar to the Milan criteria for defining good prognosis [20]. Of the 7,658 study patients, 3,009 (39.29%) met the Hangzhou criteria, with 38.75% patients (2,775/7,162) in the HBV-HCC group and 47.18% patients (234/496) in the HCV-HCC group. We calculated the 1-year, 3-year and 5-year overall, tumor-free and hepatitis-free survival rates from the operation date and compared these rates between the HBV-HCC and HCV-HCC groups, first for all patients and then for those who met the Hangzhou criteria.
The judgment for hospital mortality of the transplant patient is based on the postoperative information. In the CLTR database, the cases marked with hospital mortality have following features: a) the last follow-up date = the date of hospital discharge = the date of death; and/or b) the last follow-up date = transplant date; and/or c) the last follow-up date is later than the hospital discharge date and transplant date, but only within a few days. The 1-year, 3-year and 5-year overall, tumor-free and hepatitis-free survival rates were also analyzed after excluding cases of hospital mortality.
Statistical Methods
Descriptive statistics were expressed as median (interquartile range). The chi square test or Fisher test was used for univariate comparisons where appropriate. For univariate survival analysis, plots were created and comparisons were made using the Kaplan-Meier method. The multivariate Cox proportional hazards regression analysis was used to identify predictors of recipient survival. Differences were considered statistically significant at P≤0.05. All statistical analyses were performed using SAS software, version 9.2.
Patient Profiles
The patient profiles and overall characteristics are listed in Table 1. Of the 7,658 study subjects, 7,162 had HBV-HCC and 496 had HCV-HCC. Significant differences in sex distribution were observed between the HBV-HCC and HCV-HCC groups; 91.01% of HBV-HCC recipients (6,518/7,162) were male, while only 81.85% of HCV-HCC recipients (406/496) were male (P<0.001). The median duration of follow-up was 12.43 months (range, 3.42–29.61 months) for all patients. The following parameters significantly differed between the HBV-HCC and HCV-HCC groups (differences shown as HBV-HCC vs. HCV-HCC): age, number of tumors (median 1, range 1–3 vs. median 2, range 1–4), size of largest tumor (median 4 cm, range 2.5–7.0 cm vs. median 3.3 cm, range 2.5–5.0 cm) and preoperative AFP level (median 142.66 ng/ml, range 14.45–1,000 ng/ml vs. median 55.78 ng/ml, range 11.95–590.15 ng/ml). However, no significant difference was observed in the sum of tumor diameters (median 5 cm, range 3–10 cm vs. median 5 cm, range 3–9.5 cm, P = 0.631). Downstaging treatments, including TACE, RFA, percutaneous ethanol injection, systemic chemotherapy and combination therapy, were more common in the HCV-HCC group (P<0.001). The incidence of vascular invasion did not significantly differ between the HBV-HCC and HCV-HCC groups (P = 0.471).
Postoperative Complications
No significant differences existed in the rates of postoperative biliary and vascular complications and infections. However, compared to the HBV-HCC recipients, the HCV-HCC recipients showed a high incidence of renal failure and graft dysfunction (P = 0.015 and P = 0.006, respectively; Table 2).
Survival Analysis
In all recipients, the 1-year, 3-year and 5-year overall survival rates were 75.92%, 55.84% and 48.53%, respectively, and the corresponding tumor-free survival rates were 63.13%, 46.86% and 40.67%.
HCC recurrence was detected in 25.27% of all patients (1,935/7,658), 26.39% of HBV-HCC patients (1,890/7,162) and 9.07% of HCV-HCC patients (45/496) (P<0.001). In all, 186 recipients developed hepatitis recurrence, including 173 patients with hepatitis B and 13 with hepatitis C (P = 0.774). In the HBV-HCC group, HCC recurrence was significantly more common in patients with recurrent hepatitis B (75/173, 43.35%) than in patients without recurrent hepatitis B (1,815/6,989, 25.97%; P<0.001). However, in the HCV-HCC group, no significant difference was observed in the incidence of HCC recurrence between patients with recurrent hepatitis C (2/13, 15.38%) and those without recurrent hepatitis C (43/483, 8.90%; P = 0.422).
The 1-year, 3-year and 5-year overall survival rates (76.65%, 56.61% and 49.10%, respectively) were significantly higher in the HBV-HCC group than in the HCV-HCC group (64.59%, 42.78% and 39.20%, respectively; P<0.001). The corresponding tumor-free survival rates (63.55%, 47.37% and 40.99%) were also significantly higher in the HBV-HCC group than in the HCV-HCC group (56.84%, 38.04% and 35.66%; P<0.001). In addition, the corresponding hepatitis-free survival rates were significantly higher in the HBV-HCC group (75.49%, 54.84% and 47.34%) than in the HCV-HCC group (63.87%, 42.15%, and 39.33%; P<0.001).
Pre-transplant status, as judged by number of tumor nodules, size of largest tumor, preoperative AFP level and neoadjuvant treatment, significantly differed between the HBV-HCC and HCV-HCC groups, and may have influenced the survival rates. We therefore repeated the survival analysis for only recipients who satisfied the Hangzhou criteria. HCC recurrence was observed in 16.98% (511/3,009) of all patients who met the Hangzhou criteria, and 17.95% (498/2,775) of HBV-HCC patients and 5.56% (13/234) of HCV-HCC patients who met the Hangzhou criteria (P<0.0001). Moreover, hepatitis recurrence occurred in 80 (2.66%) recipients who met the Hangzhou criteria, including 69 (2.49%) in the HBV-HCC group and 11 (4.70%) in the HCV-HCC group (P = 0.043).
Moreover, among the patients who met the Hangzhou criteria, the 1-year, 3-year and 5-year overall survival rates were significantly higher in the HBV-HCC group (86.89%, 74.71% and 68.99%, respectively) than in the HCV-HCC group (75.08%, 56.32% and 50.46%, respectively; P<0.001; Fig. 2). Similarly, compared to the HCV-HCC group, the HBV-HCC group had significantly higher 1-year, 3-year and 5-year tumor-free survival rates (75.98%, 63.93%, 58.85% vs. 68.89%, 52.55%, 48.92%, respectively; P = 0.002; Fig. 3) and hepatitis-free survival rates (85.52%, 72.40%, 66.69% vs. 73.62%, 55.39%, 51.12%, respectively; P<0.001; Fig. 4).
Hospital mortality was 4.56% in the entire cohort, 4.44% (318/7,162) in the HBV-HCC group and 6.25% (31/496) in the HCV-HCC group (P = 0.0616). Survival analysis was repeated after excluding cases of hospital mortality, and results similar to those shown above were obtained (data not shown).
Multivariate Analysis
Although multiple predictors of survival were identified using univariate analysis (File S1), the important predictors for inferior overall, tumor-free and hepatitis-free survival included in the Cox regression model were as follows: hepatitis, preoperative AFP level ≥500 ng/ml, size of largest tumor >5 cm, number of tumor nodules >4, TNM stage IV, preoperative model for end-stage liver disease (MELD) score of 31–40 and vascular invasion (Table 3). In the HBV-HCC group, multivariate analysis revealed that all of the above parameters (except for hepatitis) were predictors of survival; in the HCV-HCC group, only number of tumor nodules >4, TNM stage IV and vascular invasion were associated with inferior overall, tumor-free and hepatitis-free survival, and none of these parameters reached statistical significance (File S2).
HBV-HCC and HCV-HCC are the main indications for liver transplantation. The early outcomes of liver transplantation for viral hepatitis-related HCC were unsatisfactory [21]. With the introduction of the Milan criteria by Mazzaferro et al. [22], post-transplant survival rates in patients with HCC have become comparable to the rates in patients without HCC. However, the Milan criteria and other selection criteria regard patients with HBV-HCC and those with HCV-HCC as a homogeneous group, implying that donor livers can be allocated equally to both types of patients. However, HBV-associated hepatocarcinogenesis is quite different from that associated with HCV [2], [23], [24]. In addition, recurrent hepatitis after liver transplantation has been greatly reduced in patients with HBV infection [25], but not in patients with HCV infection [26], [27]. Therefore, transplantation outcomes may differ between patients with HBV-HCC and HCV-HCC. Although Mazzaferro et al. [22] included both HBV-HCC and HCV-HCC patients in their study, they did not separately analyze the survival of these two patient groups. Notably, among the 48 HCC patients in their study, 32 (66.7%) had HCV-HCC while only 11 (22.9%) had HBV-HCC. Therefore, the Milan criteria may favor HCV-HCC patients in terms of donor liver allocation. Bozorgzadeh et al. [28] suggested that the Milan criteria might be too restrictive when applied to patients without HCV infection. Yataco et al. [19], in their study, included HCC patients who did not meet the Milan criteria, and obtained excellent, long-term, post-transplant survival in patients with chronic HBV. So it is likely that we should take the different status of virus infection into consideration in decisions about donor liver allocation to HCC patients.
We found that the overall, tumor-free and hepatitis-free survival rates after liver transplantation were significantly worse in HCV-HCC patients than in HBV-HCC patients. In our patients, the pre-transplant status of recipients with HBV-HCC differed considerably from that of recipients with HCV-HCC. The HBV-HCC patients tended to be younger. Comparisons of HBV-HCC and HCV-HCC patients who underwent liver transplantations in the USA, Japan and Italy have revealed similar findings [14], [15], [16], [17]. This difference in age may reflect differences in the timing and sources of hepatitis infections. HBV infection usually occurs during infancy or early childhood because of perinatal or child-to-child spread, whereas HCV infections are usually acquired through blood transfusion or injectable drug use during adulthood. Also, virtually all HCV patients are already cirrhotic at the time of HCC development, whereas for HBV, up to 30% may not be cirrhotic. As cirrhosis takes time to develop, this will likely be another major contributor to the difference in age observed.
We also found a higher male/female ratio, greater size of largest tumor and higher AFP level in the HBV-HCC group, and a greater number of tumors per patient and downstaging treatments in the HCV-HCC group. These clinicobiological differences, which have also been observed in other studies [14], [16], [17], were largely attributable to differences in the mechanism of hepatocarcinogenesis between HBV and HCV. Studies have shown that HCV tends to cause chronic infections (10% of HBV cases vs. 60%–80% of HCV cases) [29], possibly because of immune evasion by HCV quasispecies resulting from high rates of replication errors [29], [30]. Moreover, HCV has a 10–20-fold higher propensity to promote cirrhosis than does HBV, with 5%–10% of hepatitis C patients developing liver cirrhosis after 10 years [29]. As an RNA virus, HCV cannot integrate into host genomes [29], and different gene expression profiles have been observed between hepatitis B and hepatitis C patients [31], [32]; these differences may lead to different protein characteristics between HBV-HCC and HCV-HCC patients [33]. The differences in viral proteins and the chemical nature of the genome will probably result in different molecular events during chronic hepatitis and hepatocarcinogenesis.
In our study, postoperative graft dysfunction was more common in the HCV-HCC group; this finding is consistent with the results of Waki et al. [34]. They analyzed liver graft survival in patients with different types of viral hepatitis, using data from the United Network Organ Sharing (UNOS), and observed that recipients with HBV monoinfection had the highest graft survival, at a 1-year survival of 85.3% and 10-year survival of 63.0%. In contrast, patients with HCV monoinfection had the lowest graft survival, at a 1-year survival of 82.9% and 10-year survival of 46.1%. They also concluded that patients with HCV monoinfection had a higher risk of graft loss. In our study, renal failure was more frequent in the HCV-HCC group. Burra et al. [35] reported that the median 1-year and 5-year glomerular filtration rate was significantly lower in HCV-positive patients than in HCV-negative patients. This finding may be largely attributable to HCV-induced glomerulonephritis. Although HBV is well-known to cause glomerulonephritis [36], Lee et al. [37] found no evidence of HBV-related immune complex glomerulonephritis on kidney biopsy in patients who underwent liver transplantation for HBV-related liver disease. The difference in the incidence of renal failure may also be related to the age differences between the HBV-HCC and HCV-HCC groups. Lee et al. [37] has shown that old age is a predictor for the development of chronic kidney disease after liver transplantation.
In our analysis, the overall, tumor-free and hepatitis-free survival rates were all significantly better in the HBV-HCC group, both when the entire cohort was considered and when only patients meeting the Hangzhou criteria were considered. These findings demonstrated that survival after liver transplantation did differ between recipients with HBV-HCC and those with HCV-HCC, regardless of differences in pre-transplant status. In addition, the multivariate analysis also identified type of viral hepatitis as an important predictor of survival, implying that the difference in virus infection has significantly affected post-transplant survival and recurrence.
The differences in survival between the HBV-HCC and HCV-HCC groups may largely attribute to two factors. First, differences in the prophylactic regimens for hepatitis recurrence between HBV and HCV might lead to differences in graft survival between these two groups of recipients, and therefore to different overall survival. Second, differences in the mechanisms of hepatocarcinogenesis between HBV and HCV may lead to different clinical profiles as mentioned above and affect post-transplantation recovery and HCC or hepatitis recurrence.
Our findings demonstrate that the differences in survival rates after liver transplantation between the HBV-HCC and HCV-HCC groups were attributable to not only differences in tumor recurrence rates but also differences in hepatitis recurrence rates. Hepatitis may recur because of intra- and extrahepatic viral reservoirs [38], whereas HCC recurrence might be caused by pretransplant or intra-operative spread of remnant tumor cells after a long time in a dormant state [39]. Both hepatitis recurrence and tumor recurrence can lead to graft failure and clinical decompensation, which impair recipient survival [12], [40], [41]. Nevertheless, the relationship between HCC recurrence and hepatitis recurrence after liver transplantation remains controversial. Some studies have shown that hepatitis recurrence is a risk factor for HCC recurrence, and that combination therapy for the prevention of hepatitis recurrence significantly improves overall and tumor-free survival following liver transplantation [42]. However, other studies have contradicted these findings, suggesting that HCC recurrence is a critical component for hepatitis recurrence [10], [43], [44] and that impaired immunity due to the cumulative corticosteroid dose and chemotherapy used for HCC recurrence lead to hepatitis recurrence [45]. Li et al. [46] observed a strong correlation between the timing of hepatitis recurrence and HCC recurrence. Our study demonstrated that in HBV-HCC patients, hepatitis B recurrence was associated with a higher incidence of HCC recurrence; however, a similar association was not found in the HCV-HCC patients. This may be because recurrent/metastatic HCC cells may support HBV replication and therefore be the source of HBV recurrence. Whereas in HCV, for those patients who are viraemic at the time of transplantation, almost all might have persistent infection; moreover, HCV-HCC patients who develop hepatitis C recurrence might die early, before they can develop HCC recurrence. Therefore the association with HCC is unlikely to be observed with HCV. However, the underlying mechanisms should be evaluated in future studies. So regarding these discrepancies between HBV-HCC and HCV-HCC patients, the developments of more accurate prediction algorithms based on meticulous evaluation of patient prognosis might be needed.
Our study has some limitations. First, as the study was not randomly assigned and included data from transplant centers all around China, the heterogenous nature of the data due to various criteria, definitions, as well as protocols among different centers - including definitions of HBV recurrence, antiviral therapy, post-transplant screening procedures for HCC, etc. - may have confounded our analysis. Second, because this was a clinical research study, which lacks the strong evidence of basic research studies, we could not fully explain the mechanisms underlying hepatitis or tumor recurrence that probably led to differences in survival between the HBV-HCC and HCV-HCC patients. Thirdly, the large number of missing data in the variable'sum of tumor diameter' may result in a potential bias in statistical analysis. This may be largely due to the factor that many recipients have diffuse tumor nodules, especially for those exceeding Hangzhou criteria, making it difficult to access the parameter accurately in reality. Fourthly, the relative short follow-up period (median of about1 year) makes it difficult to invest the long-term effects of different viruses on liver transplant recipients. Despite these limitations, our study represents the most comprehensive assessment of survival after liver transplantation in HBV-HCC and HCV-HCC patients to date, because we used data from the CLTR, which contains information on all liver transplants performed in China. Therefore, our results remain important in the development of donor liver allocation in patients with different types of viral hepatitis.
In conclusion, HCV-HCC patients have significantly worse overall, tumor-free and hepatitis-free survival after liver transplantation than HBV-HCC patients. Liver transplant recipients with HCV-HCC tended to be older and developed postoperative graft dysfunction and renal failure more frequently than recipients with HBV-HCC. Given the scarcity of donor livers, our findings might be considered to guide the development of future donor liver allocation protocols in transplantation programs, to take recipients with the same secondary diagnoses but with different primary diagnoses/etiologies into different considerations, in order to benefit those candidates who might obtain relatively superior survival rates more and thus improve overall survival in the total transplant population.
Supporting Information
File S1.
Univariate survival analysis for patients with hepatocellular carcinoma.
File S2.
Multivariate analysis for patients with hepatitis B virus or hepatitis C virus -associated hepatocellular carcinoma.
We gratefully acknowledge the China Liver Transplant Registry (CLTR) in data collection and statistical analyses.
Author Contributions
Conceived and designed the experiments: SZ. Performed the experiments: ZL LZ JW MZ. Analyzed the data: ZL SL YH. Contributed reagents/materials/analysis tools: ZH JZ HW. Wrote the paper: ZH JZ.
- 1. Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030–3044.
- 2. Castello G, Scala S, Palmieri G, Curley SA, Izzo F (2010) HCV-related hepatocellular carcinoma: From chronic inflammation to cancer. Clin Immunol 134: 237–250.
- 3. Lai CL, Ratziu V, Yuen MF, Poynard T (2003) Viral hepatitis B. Lancet. 362: 2089–2094.
- 4. Liu J, Fan D (2007) Hepatitis B in China. Lancet 369: 1582–1583.
- 5. Custer B, Sullivan SD, Hazlet TK, Iloeje U, Veenstra DL, et al. (2004) Global epidemiology of hepatitis B virus. J Clin Gastroenterol 38: S158–168.
- 6. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74–108.
- 7. Chisari FV (2005) Unscrambling hepatitis C virus-host interactions. Nature 436: 930–932.
- 8. Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, et al. (2011) A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver Int 31 Suppl 261–80.
- 9. Gane EJ (2008) The natural history of recurrent hepatitis C and what influences this. Liver Transpl 14 Suppl 2S36–44.
- 10. Saab S, Yeganeh M, Nguyen K, Durazo F, Han S, et al. (2009) Recurrence of hepatocellular carcinoma and hepatitis B reinfection in hepatitis B surface antigen-positive patients after liver transplantation. Liver Transpl 15: 1525–1534.
- 11. Feray C, Caccamo L, Alexander GJ, Ducot B, Gugenheim J, et al. (1999) European collaborative study on factors influencing outcome after liver transplantation for hepatitis C. European Concerted Action on Viral Hepatitis (EUROHEP) Group. Gastroenterology 117: 619–625.
- 12. Berenguer M, Prieto M, Rayon JM, Mora J, Pastor M, et al. (2000) Natural history of clinically compensated hepatitis C virus-related graft cirrhosis after liver transplantation. Hepatology 32: 852–858.
- 13. Berenguer M, Ferrell L, Watson J, Prieto M, Kim M, et al. (2000) HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol 32: 673–684.
- 14. Stroffolini T, Andreone P, Andriulli A, Ascione A, Craxi A, et al. (1998) Characteristics of hepatocellular carcinoma in Italy. J Hepatol 29: 944–952.
- 15. Di Bisceglie AM, Simpson LH, Lotze MT, Hoofnagle JH (1994) Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection. J Clin Gastroenterol 19: 222–226.
- 16. Shiratori Y, Shiina S, Imamura M, Kato N, Kanai F, et al. (1995) Characteristic difference of hepatocellular carcinoma between hepatitis B- and C- viral infection in Japan. Hepatology 22: 1027–1033.
- 17. Miyagawa S, Kawasaki S, Makuuchi M (1996) Comparison of the characteristics of hepatocellular carcinoma between hepatitis B and C viral infection: tumor multicentricity in cirrhotic liver with hepatitis C. Hepatology. 24: 307–310.
- 18. Forman LM, Lewis JD, Berlin JA, Feldman HI, Lucey MR (2002) The association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology 122: 889–896.
- 19. Yataco M, Bonatti H, Machicao V, Mendez J, Stauffer J, et al. (2010) Long term survival and complications after liver transplantation in patients with chronic hepatitis B. Ann Transplant. 15: 27–34.
- 20. Zheng SS, Xu X, Wu J, Chen J, Wang WL, et al. (2008) Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation 85: 1726–1732.
- 21. Wong PY, McPeake JR, Portmann B, Tan KC, Naoumov NV, et al. (1995) Clinical course and survival after liver transplantation for hepatitis B virus infection complicated by hepatocellular carcinoma. Am J Gastroenterol 90: 29–34.
- 22. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, et al. (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334: 693–699.
- 23. Neuveut C, Wei Y, Buendia MA (2010) Mechanisms of HBV-related hepatocarcinogenesis. J Hepatol 52: 594–604.
- 24. Farazi PA, DePinho RA (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674–687.
- 25. Cholongitas E, Goulis J, Akriviadis E, Papatheodoridis GV (2011) Hepatitis B immunoglobulin and/or nucleos(t)ide analogues for prophylaxis against hepatitis b virus recurrence after liver transplantation: a systematic review. Liver Transpl 17: 1176–1190.
- 26. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A, et al. (2002) Combination of interferon alfa-2 b and ribavirin in liver transplant recipients with histological recurrent hepatitis C. Liver Transpl. 8: 1000–1006.
- 27.
Belli LS, Volpes R, Graziadei I, Fagiuoli S, Starkel P, et al.. (2012) Antiviral therapy and fibrosis progression in patients with mild-moderate hepatitis C recurrence after liver transplantation. A randomized controlled study. Dig Liver Dis.
- 28. Bozorgzadeh A, Orloff M, Abt P, Tsoulfas G, Younan D, et al. (2007) Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis. Liver Transpl 13: 807–813.
- 29. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5: 215–229.
- 30. Weiner A, Erickson AL, Kansopon J, Crawford K, Muchmore E, et al. (1995) Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A 92: 2755–2759.
- 31. Iizuka N, Oka M, Yamada-Okabe H, Mori N, Tamesa T, et al. (2002) Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res 62: 3939–3944.
- 32. Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, et al. (2001) Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 61: 2129–2137.
- 33. Kim W, Lim SO, Kim JS, Ryu YH, Byeon JY, et al. (2003) Comparison of proteome between hepatitis B virus- and hepatitis C virus-associated hepatocellular carcinoma. Clin Cancer Res 9: 5493–5500.
- 34. Waki K, Sugawara Y, Tamura S, Mieno MN, Yamashiki N, et al. (2011) Outcome of liver transplantation for recipients with hepatitis B and hepatitis C virus coinfection: analysis of the UNOS data. Transplantation 92: 809–814.
- 35. Burra P, Senzolo M, Masier A, Prestele H, Jones R, et al. (2009) Factors influencing renal function after liver transplantation. Results from the MOST, an international observational study. Dig Liver Dis 41: 350–356.
- 36. Johnson RJ, Couser WG (1990) Hepatitis B infection and renal disease: clinical, immunopathogenetic and therapeutic considerations. Kidney Int 37: 663–676.
- 37. Lee JP, Heo NJ, Joo KW, Yi NJ, Suh KS, et al. (2010) Risk factors for consequent kidney impairment and differential impact of liver transplantation on renal function. Nephrol Dial Transplant 25: 2772–2785.
- 38. Seehofer D, Berg T (2005) Prevention of hepatitis B recurrence after liver transplantation. Transplantation 80: S120–124.
- 39. Schlitt HJ, Neipp M, Weimann A, Oldhafer KJ, Schmoll E, et al. (1999) Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol 17: 324–331.
- 40. Han SH, Reddy KR, Keeffe EB, Soldevila-Pico C, Gish R, et al. (2011) Clinical outcomes of liver transplantation for HBV-related hepatocellular carcinoma: data from the NIH HBV OLT study. Clin Transplant 25: E152–162.
- 41. Berenguer M (2002) Natural history of recurrent hepatitis C. Liver Transpl. 8: S14–18.
- 42. Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, et al. (2007) Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Transplant Proc. 39: 3276–3280.
- 43. Chun J, Kim W, Kim BG, Lee KL, Suh KS, et al. (2010) High viremia, prolonged Lamivudine therapy and recurrent hepatocellular carcinoma predict posttransplant hepatitis B recurrence. Am J Transplant 10: 1649–1659.
- 44.
Faria LC, Gigou M, Roque-Afonso AM, Sebagh M, Roche B, et al.. (2008) Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. Gastroenterology 134: 1890–1899; quiz 2155.
- 45. Yi NJ, Suh KS, Cho JY, Kwon CH, Lee KW, et al. (2007) Recurrence of hepatitis B is associated with cumulative corticosteroid dose and chemotherapy against hepatocellular carcinoma recurrence after liver transplantation. Liver Transpl 13: 451–458.
- 46. Li MR, Chen GH, Cai CJ, Wang GY, Zhao H (2011) High hepatitis B virus DNA level in serum before liver transplantation increases the risk of hepatocellular carcinoma recurrence. Digestion 84: 134–141.


text:
Sweet AR. Nice to do an AR assembly after a few AK builds.
Never figured how our economy is in utter ruin and I didn't ever notice. Guess it was like Tipper Gore stating 10% of the population is depressed and don't know it. Hmmmm, go figure, but won't complain about the Feds giving me back some of my tax money they thought they had to have.
AR is a great investment to help strengthen the American economy


text:
LOCATION Found in 1972 by the French Archaeological Mission, buried in the plaza about 150 m west of the group of sculptures assembled by Aurea Cruz, and probably not in its original setting. It remains in the area near the ball court.
CONDITION Except for a loss extending nearly halfway round its upper edge, the altar is intact, but severe erosion is evident over all the periphery and part of the upper surface.
MATERIAL Probably limestone.
SHAPE CylindricaL
CARVED AREAS The upper surface and periphery.
PHOTOGRAPHS Graham.
DRAWING Graham, based on a field drawing.


text:
I, too, like the Springfield XD. Mine was a .40 and was a very accurate gun. In .45 GAP I think the potential is even better....
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I, too, like the Springfield XD. Mine was a .40 and was a very accurate gun. In .45 GAP I think the potential is even better....
the GAP...It's sorta the answer to the unasked question
I agree with this statment for me anyways but i could see where the Mrs could enjoy the Gap in a 1911 she loves 1911 pattern even though she doesnt complain much about grip size but i can see the smaller 1911 would be good for her
The EAA CZ clone is called the Witness, and I have had the full size steel model. I sold it when I got the 1911 bug, but wish I hadn't. Very nice shooting accurate gun, and very reliable. If you get the .45 you can later order new barrel/slide combos for just about any other caliber, not so if you start out with a smaller frame like 9mm. They have multiple barrel/slide lengths to choose from and a polymer version. The gun is a very good value for the price, and there are lots of upgrades to make it into whatever you want it to be.
Mine held 10+1, but it was bought during the ban. There are high/standard caps available, but I don't know how many they hold. It is a double stack mag.
I have heard that EAA customer service is not stellar, but I never had cause to use it.
HK USP45f. I have had a few other 1911 style 45s and this one I like best.12+1 ,suppressable, various aftermarket barrell options and out of the box accurate.I don't know of other pistols you can drop an empty mag out and slam a new one in and it will rack the slide by full mag force.its known to do that and a + I think.the price is not bad,you get what you pay for.
The Hk is known to do this but its not designed to ... My one 1911 will do this as well i know it needs a slide stop though ..Quote:
Originally Posted by USP45
It was designed to do that and most people did not like it so it was changed to be less likely to do it.I cannot consistently do it but I just threw that in as an added feature because there has been only a few times I could not replicate that function,I think I will practice this.but all that aside the only downside to the HK USP I ever hear is price.for the money its well worth it.Bruce Grey used it for a long time before switching to sig 226 in competition.better info @ hkpro.com
My single serious complaint about the H&K's is the really GRITTY trigger action. I dry fired one at a gun show and it felt as if sand had been poured into the mechanism. Anybody have any experience with this? I also think the grips are too abrasive to be comfortable and concealable. Hate to have my cover garment get snagged on the grip and lead to an embarrassing "flash" incident.Quote:
Originally Posted by USP45
No gritty trigger on mine well i take that back after i flushed the frame and reoiled everything no gritty trigger...
I use a hogue handall on mine becuse of big hands but am going to take it off for thinner grip for carry i never had a problem with snaggin b4 or after the hogue handall seems the hogue would grab more with its kind of sticky feeling...
I have a USP in .40 SW and my trigger feels okay, as well. A bit longish, but to be fair, I don't shoot it much. I should.
I like the gun, I just don't really see it as 'my' combat gun.
what budwhite said,exactly.
Gee, I'm glad I read this column, if only for my education. I didn't know anybody made an autoloader besides the 1911 Colt .45 ACP. Did you, Bob? Ive just been buying the same ol' thing, over, and over, and over. Gov't models, Gold Cups, and Officers Model. Don't know about them other new-fangled doo dads. I hear some are made of Tupperware. Zat true?
I actually got this morning a rather long letter from the folks at ParaOrdnance on my "issues" and they gave me a link to the PO LDA that is 14+1 and has the accessories rail, so I can hang a SureFire X200 for the home mode...I can't remember the name of the model, but it looks really good. If I'm going back to a full size 15rds to start with sounds mighty impressive. I'm liking this idea a whole lot more. If I do this and I REALLY like it, I might also pick up a TAC-4 (SpecOps model) for the wife. Well, she'll be my EXCUSE anyway.Quote:
Originally Posted by CLASS3NH
My other complaint with the H&K USP models besides the gritty trigger is a really ABRASIVE finish that is not only uncomfortable, but downright annoying to deal with.
Probably the PXD LDA Models.the Covert Black, the Colonel, the Covert Black Ops.......all with 14+1 cap....they also make the 16 and 18 shot models as well..<not sure if they have the rail or not tho>
Yes, the USPs take a little patience to get accustomed to as well........ :biggrin: Glad to see we're all giving you good input :biggrin:
This is the link: http://www.paraord.com/product/product.html?id=49Quote:
Originally Posted by CLASS3NH
hum 15 shot 45 now that would be sweet not sure if iw ould like LDA trigger though


text: I have one name for you, Trixie Schuba. Many of us know what I am talking about. I remember the absolute fiasco of Trixie Schuba winning because of her superior figures. Unfortunately, she skated a really awful LP but won because of her figures. That's why they changed the system amd I was 100% for it. Still am. That should never happen again. That is the one part of the system I wouldn't change.


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Josh HuffTampa Bay Buccaneers
Wide Receiver
Ht: | Wt:
News | Stats | Stat vs. Team | Targets | Injury | Depth Chart | Roster
|Rec Yds
|Rec Avg
|Rec TD
|Rec 2pt
|Rush Yds
|Rush Avg
|Rush TD
|Rush 2pt
|Fum Lost
|Buccaneers | Josh Huff could help Tampa Bay
Sat, 10 Dec 2016 19:18:30 -0800
Tampa Bay Buccaneers WR Josh Huff is "blazing," according to QB Jameis Winston, and Winston believes Huff's abilities will add to the offense as the two continue to develop chemistry.
Fantasy Tip: Injuries to the receiving corps will likely thrust Huff into a sizeable role in Tampa Bay's passing attack against a weak Saints defense in Week 14, but he will no more than a shot-in-the-dark DFS option in his team debut.
|Comment (0)
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|| Source: Tampa Bay Times - Greg Auman
|Buccaneers | Josh Huff will play Sunday
Sat, 10 Dec 2016 08:43:21 -0800
Tampa Bay Buccaneers WR Josh Huff will be active for Week 14's game against the New Orleans Saints, according to head coach Dirk Koetter.
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|| Source: Sirius XM NFL Radio - Alex Marvez
|Buccaneers | Two roster moves made by Bucs
Tue, 06 Dec 2016 13:25:37 -0800
Tampa Bay Buccaneers WR Cecil Shorts III (knee) was placed on the Reserve/Injured list Tuesday, Dec. 6. WR Josh Huff was promoted to the active roster in place of Shorts.
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|| Source: Tampa Bay Times - Greg Auman
|Buccaneers | Josh Huff won't play
Fri, 18 Nov 2016 20:18:39 -0800
Tampa Bay Buccaneers WR Josh Huff (undisclosed) likely won't be able to play against the Kansas City Chiefs in Week 11 after suffering an injury in practice Friday, Nov. 18, according to head coach Dirk Koetter.
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|| Source: Sirius XM NFL Radio - Alex Marvez
|Buccaneers | Josh Huff added to Bucs
Mon, 07 Nov 2016 08:59:31 -0800
Free-agent WR Josh Huff (Eagles) was signed to the Tampa Bay Buccaneers' practice squad Monday, Nov. 7.
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|| Source: The Tampa Tribune - Roy Cummings
|Eagles | Josh Huff released
Thu, 03 Nov 2016 08:35:33 -0700
Philadelphia Eagles WR Josh Huff was released Thursday, Nov. 3.
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|| Source: PhiladelphiaEagles.com
|Eagles | Josh Huff arrest update
Tue, 01 Nov 2016 22:46:47 -0700
Updating a previous report, Philadelphia Eagles WR Josh Huff has been summoned to appear in court Tuesday, Nov. 15, to address charges from his arrest Tuesday, Nov. 1. In addition to being in possession of an unlicensed firearm and marijuana, Huff also had a magazine with six hollow-point bullets.
Fantasy Tip: Huff's primary value to the Eagles has been special teams, but depending on how the team/NFL react to this incident it could spell more opportunities for Dorial Green-Beckham.
|Comment (0)
|| Share:
|| Source: The Philadelphia Inquirer - Jeff McLane
|Eagles | Josh Huff arrested
Tue, 01 Nov 2016 15:46:45 -0700
Philadelphia Eagles WR Josh Huff was arrested Tuesday, Nov. 1, on gun and marijuana charges. Huff was charged with possession of a 9 mm handgun without a permit and having a small amount of marijuana after he was pulled over for speeding on the Walt Whitman Bridge between Philadelphia and New Jersey.
Fantasy Tip: Huff is a WR3 on his own team, so Dorial Green-Beckham could see more catches if Huff is benched for this incident.
|Comment (0)
|| Share:
|| Source: USA TODAY Sports - A.J. Perez
|Eagles | Special teams might save Josh Huff
Wed, 17 Aug 2016 21:47:13 -0700
Philadelphia Eagles WR Josh Huff is entering his third year with the team, and the clock is ticking on his usefulness as a receiver. His competency in the kick return game might be the only reason he remains on the final roster.
Fantasy Tip: Huff can be avoided in most standard fantasy formats, although he is an intriguing play in deeper leagues which reward individual return yardage.
|Comment (0)
|| Share:
|| Source: The Philadelphia Inquirer - Jeff McLane
|Eagles | Sam Bradford working out with teammates
Wed, 06 Jul 2016 15:30:17 -0700
Philadelphia Eagles QB Sam Bradford is working out with several of his teammates in San Diego leading up to training camp. QBs Chase Daniel and Carson Wentz, RB Darren Sproles, WRs Jordan Matthews, Josh Huff, T.J. Graham and Rueben Randle and TE Zach Ertz are among the players participating in the workouts.
Fantasy Tip: Bradford is trying to build chemistry with his receivers so they can start the season off strong. Bradford should only be considered as a No. 2 quarterback in fantasy leagues. Matthews and Ertz will be among the leaders in targets for the Eagles this season and likely will be selected in the middle rounds of drafts. Sproles should have a role in the running and passing game in 2016 and could be a late-round option who will have more value in point-per-reception leagues. Huff and Randle are only late-round options in deeper leagues.
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|| Source: NJ.com - Eliot Shorr-Parks


text:
Lawyers don't often get an opportunity to really cut loose and say exactly what it is they (or their clients) are thinking. We couch everything in very neutral terms and our threats are often veiled. But apparently there are vanishingly rare occasions where the absurdity of the threatened legal action matches up nicely with the devil-may-care attitude of a client, and then you get the stuff of internet magic: the epic smackdown letter.
We all long to write one, but few of us ever will. Here are some of the best we've found. Some of these were ostensibly written by the clients themselves, but we are just going to pretend that some lawyer somewhere got to give the go-ahead to those as well.


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Clayton, MO, USA < change city >
Photographers (60)
Florists (34)
Caterers (27)
Bands (22)
DJs (20)
Cakes (20)
Limos (17)
Wedding Day Beauty (15)
Wedding Fashion (14)
Videographers (12)
Tuxedos (11)
Coordinators (8)
Officiants (8)
Invitations (8)
Jewelry (6)
Ceremony Sites (378)
Reception Sites (278)
See All Vendors >
Clayton Wedding In May
Ceremony at Immaculate Conception Church
Reception at St Louis Artists' Guild
Clayton Wedding In May
Ceremony at St Joseph's Church
Reception at World's Fair Pavillion
Saint Louis Wedding In May
Ceremony at Cliff Cave County Park
Reception at Genesis Catering
"Our wedding was great! Getting married in St. Louis was wonderful. The c..."
Our Wedding
Ceremony at Piper Palm House
Reception at Mad Art Gallery
"A fantastic day!! Well worth all the effort with the DIY projects. It w..."
Our Wedding
Ceremony at Top of the Met
"Our wedding was beautiful. Everything from the venue, the flowers, the d..."
O'Rourke/Hines Wedding
Ceremony at St Boniface Catholic Church
Reception at The Sheldon Concert Hall and Art Galleries
"Our wedding was absolutely perfect! The vendors and venues could not have been better! All of our guests still rave a..."
Charlie and Marie's Wedding
Ceremony at Saint Vincent DePaul Parish
Reception at Windows Off Washington
"We got married in Saint Louis in May. The weather was beautiful and our ..."
Jennifer and Trent 's Wedding
"Our wedding was great! The folks at Catering St. Louis and the Missouri Botanical Garden were helpful when the weath..."
Kelly and Matthew's Wedding
Ceremony at Old Cathedral
Reception at Windows On Washington
"Incredible Day! We couldn't have had a more perfect wedding and wedding ..."
Carrie and Ryan's Wedding
Ceremony at St Peter's Catholic Church
Reception at The Magic House, St. Louis Children's Museum


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Bronx, NY, USA < change city >
Photographers (160)
Florists (114)
Bands (106)
Wedding Day Beauty (98)
DJs (93)
Cakes (72)
Limos (54)
Wedding Fashion (52)
Invitations (43)
Videographers (42)
Coordinators (39)
Officiants (26)
Favors (22)
Jewelry (22)
Ceremony Musicians (18)
Ceremony Sites (681)
Reception Sites (472)
See All Vendors >
Lyvia and Murice's Wedding
Ceremony at The Greater Holy Tabernacle Church
Reception at The Eastwood Manor
Bronx Wedding In August
Ceremony at Saint Thomas Aquinas Church
Reception at The Sanz
Bronx Wedding In August
Ceremony at Bartow-Pell Mansion
Reception at The Eastwood Manor
Leyda and Lawrence's Wedding
Kristie and Eric's Wedding
Ceremony at The Foundry
Reception at The Foundry
"Our wedding turned out perfectly! New York is absolutely one of the mos..."
Allison and Mario's Wedding
Ceremony at The New York New Church
Reception at Persona
"NYC is the way to go for a wedding that you and your guests will remembe..."
Gina and Keith's Wedding
Ceremony at UN Chapel
Reception at UN Delegates Dining Room
"We had the most spectacular wedding in NYC! It was a warm August night with full moon and all. Had a wonderful short ..."
Christina and Michael's Wedding
Ceremony at St. Thomas Armenian Church
Reception at Rockleigh Country Club
"The Rockleigh Country Club was amazing. It can be pricey in the peak wedding season, but it's totally worth it. Oh, ..."
Erinn and Jeremy's Wedding
Ceremony at The Womans Club of Englewood
Reception at The Women's Club of Englewood
"Our wedding could not have been better. We wanted an inexpensive, yet cl..."
Marlene and Pierre's Wedding
Ceremony at St. Peter Church
Reception at The Surf Club
"We had a beautiful August day, St. Peter's Church is the only church I wanted to get married in, just a beautiful old..."


text:
Member Since: March 21, 2006
Country: United States
Just kidding. My participation depends on whether I can get my design working.
If you get Tiffany Brissette to wave a flag in the start line, I will consider it…
Congrats on choosing a true test of merit in choosing a new Sparkfun team member!
What's the recommended compiler and programmer software for this dev board? I haven't had success with my Pickit 1 and 16F688, it is always "Checksum verify failed" on Classic Flasher 1.31, with a HEX produced by Oshonsoft Basic. I haven't tried flashing from within the Microchip IDE yet because the included ASM and C samples have a degree of difficulty to port from chip to chip.
Hopefully the compiler and programmer for this board are Linux based.
No public wish lists :(


text:
It looks like you're new here. If you want to get involved, click one of these buttons!
Sounds as though you're back on track MadameO.
emzap - managed to miss your marathon news yesterday - which one?
What: swim am/threshold turbo pm
Why: sometimes I do ask myself this
Last hard: 22/1
Last rest: 3/3
Lyrics - don't think they're what initially sprung to mind.
Pammie/LMH it's the Belfast marathon, 7th May. Anyone here doing it?
What: 8 miles
Why: With a friend who also signed up!
Lyrics: No
It's my review at work today. Fingers crossed for good news...
Morning all,
Very foggy here in SE Wales too!
Emzap - good luck with the review!
MadameO - I have only entered one of those races at the moment, but I think that the only one that may get knocked on the head is Liverpool on 1st July. So yes, a busy schedule but I'm one of those that needs something to focus on! And yes, loving being a dad!! 3rd time for me but Mrs AH's first. My elder 2 are 11 and 13 now, so it all feels very new again!
Good training all!
Paddy have you done Belfast before?
Good news re review. Promotion and perm contract
Good luck today Emzap!
Paddy - that would indeed be a doghouse double whammy if you were to disappear on Sunday!! Yes, it is the VLM I'm doing. G and I are going down early on Saturday morning to go to the expo, and staying for two nights - visiting my favourite dress shop on Monday to reward/commiserate myself, depending on race time Whereabouts are you staying?
As for the treadie, most runners I speak to are horrified that I do my speedwork on it, because it does the work for me in keeping the pace... which is true I suppose, but when I'm having difficulty maintaining a constant pace it can help to be forced into it by flashing red numbers and a moving belt. As I get fitter it'll help get me out of the rut I feel stuck in.
A more general observation, that sort of ties in - I've noticed that a lot of advice, whether running-related or other, tends to be very focused on 'ideal' scenarios. This is probably why a lot of people find it so hard to make positive changes; they don't feel in a position to do it completely, so they wait until they feel they can... and that time never comes. Over the last few months I've taken a more gradual approach to sorting my life out (training, finances, diet) and it's really helping.
What: 8-10 miles easy
Why: Midweek long run shifted over a bit
Last hard: Yesterday's session on the Treadmill of Doom
Last rest: Tuesday
Lyrics: No, but feel I should...
Have a good day everyone.
X-post - took me way too long to type that as had too many interruptions!
Well done Emzap
afternoon all
lyrics, no Idont think so
paddy its a bit of a weekend for me too, good old st patricks day is when I was born!
alex h aah thats nice being a dad again!
what: few miles later
why: thursday run
last hard: yesterday morning bike commute, 19.5 miles of slog!
last easy: sat
have a good day all
Still not fully caught up.
Paddy: Enjoy St Paddys Day
Great news Emzap!
Freezing here...well 5 degrees and foggy!
What: will have a walk later.
Lyrics: no not know
Paddy Enjoy Patricks day
Wabo Wahey Good celebrations on Sunay
Emzap Congrats
What: 8 miles
Why: its a nice day -What? ok base and consistant consistency
Last Hard: Sunday
Lyrics Nope
Great news emzap - is the move to Germany no longer on the cards?
Paddy - definitely not on Sunday then!
Something nice planned for your birthday I hope Wabo?
More good miles there Pammie.
Hi Des, I'm the guy who started training really hard and properly after his marathon last year! Then stopped in about August, when my wife was heavily pregnant and could no longer help with dog walking etc. After a hiatus until now and putting a stone back on...I'm back, only to be laid low with sinusitis this week.
Therefore, today's update is
What: nothing
Why: Thought about swimming but no public session in my local on a Thursday night!
Last hard: hahaha
Last rest: this week!
greetings all,
excellent news emzap
been away for 2 days, back from York now, and a slow 4.5m d&d.....
Take care all


text:
The Bourne Supremacy Parent Review
Full of high-octane confrontations The Bourne Supremacy might contain too much explosive action for family viewing.
Movie Review
With the exception of a few bad dreams, black-ops agent Jason Bourne (Matt Damon) has finally settled into a more regular life in Goa, India. Yet Bourne hasn't relaxed to the point where he doesn't notice a man tailing him and his girlfriend Marie (Franka Potente). By the time the morning passes, he's back on the run-both to save his life as well as to try and complete his forgotten past.
NEW: Listen to our Parent Previews Podcast and take control of media and technology in your family!
As he works his way across Europe, the audience is treated to a mosaic of locations and scenery, while the hero dodges CIA agents who may or may not be on his side. Only the screenwriters know for sure, as even confident, takeover agent Pamela Landy can't keep control of Bourne or figure out what went wrong with the original operation. Making matters worse is the belligerent attitude of Ward Abbott (Brian Cox), who resents Landy being put in place as his superior.
But the center of this story is nearly always on Bourne. That keeps us on the edge of our seats wondering how he will escape the never-ending onslaught of police, security teams, and agents who are pursuing him. Thankfully, this script is adept at avoiding the tedium of watching one guy being chased for two hours. By having him turn the tables on his aggressors from time to time, Bourne jumps from defense to offense, making the actor's characterization of a dangerous human weapon very believable.
Yet these high-octane confrontations may prevent The Bourne Supremacy from fitting into the approved lists of summer movies for your teens (it's definitely not for younger children). A couple of scenes feature brutal hand-to-hand confrontations that become deadly when a knife is pulled, and two intense car chases result in numerous crashes with uninvolved drivers. Bloodied faces and a suicidal shot to the head (seen for a split second) are additional content concerns, as is a single use of the sexual expletive in a script that is otherwise low in profanities.
Refreshingly, this film has no sexual content, other than the assumption that Jason and Marie (who is seen in a bikini top) are unmarried and living together. Like other recent action films, it appears creators are trading off sex in favor of more explicit violence in an effort to pump up the testosterone and still stay within the PG-13 rating.
But what pushed this film into our just barely recommended viewing territory is its strong message about deciding who and what you will become, even if everyone else tells you otherwise. Learning of his history as a hired assassin, Bourne's loss of memory leaves him susceptible to believing comments from others, who say he will always be a killer. The struggle within himself to come to terms with his past and take control of what he wants for his future makes this second Bourne a more worthwhile choice than his former outing.Directed by Paul Greengrass. Starring Matt Damon, Franka Potente, Julia Stiles. Running time: 108 minutes. Theatrical release July 22, 2004. Updated May 9, 2016
The Bourne Supremacy Parents Guide
This well-crafted film's dark and dangerous illusions are magnified through the use of long lenses, handheld camera moves (which left a few audience members complaining of motion sickness) and peering through foreground obstacles-all of which add to the credible simulation of spying on our protagonist. If you have a video camera in your home, encourage your children (with your supervision) to experiment with these techniques. Can you turn some houseplants and a family pet into a jungle safari?


text: Posted March 14, 2013 That's interesting. I've never heard of their their early acoustic stuff referred to as a gimmick, but I could see some heavy metal scene kids thinking it was. I have to say I own their first Nemo album and it really isn't that great. The "Oh What a Nightmare" side project is much better, because the brother's songwriting and melodies are much stronger. Congrats on your bands' moderate success. Playing music is awesome, but to get paid for it is even more incredible. What's interesting is most charlotte bands have gotten frustrated at one point or another and considered doing something totally off the wall or ridiculous to get noticed. I knew the Truckstop Preachers pretty well before they started doing all the crazy costume and giant foam hat bits. Nobody noticed them back then, but now if I mention that band to someone who follows the local scene they know who they are, all because of the crazy outfits. Maybe it was a comment in jest by one of the Avett's and it was taken too seriously. Who knows. All I know is it worked for them and that's great. Oh and thanks for the kind words Share this post Link to post Share on other sites


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community involvementBeing a Zipster isn't just about sharing cars. Our members inspire us to reach out into the community and make a difference. We're proud to be working with organizations that are setting examples around the globe.
regional involvement
Zipcar has teamed up with AID FOR AIDS International (AFAI) to pick up unused medication that will be donated to those without access to life-saving HIV drugs in developing countries. AFAI is a non-profit organization committed to improving the lives of people in developing countries and immigrants here in the US who are living with HIV/AIDS. Their work empowers people living with this disease, as well as their caregivers, and the community at large, by providing access to medications, health education, HIV prevention strategies and advocacy.
AIDS Walk
Help support AIDS Walk New York and join the Zipcar team to help raise money to fight this disease! AIDS Walk New York supports the services provided by the GMHC in addition to other organizations representing the entire spectrum of HIV/AIDS services. Zipcar helps this great cause by donating transportation when it's needed. (Although when it comes time to walk, we park and hoof it. We promise.)
Clean Air NY
Clean Air NY is a network of individuals, employers, employees and community organizations in the New York metro area committed to the idea that every person can help clean our air (right up our ally!). The idea is to reduce vehicle miles traveled in the metro area by encouraging simple, alternative travel behaviors such as car sharing (sound familiar?). They even offer real-time Air Quality Action Day Updates, which you can sign up for on their website or by texting CLEAN to 42269 (standard text message rates apply). Clean Air NY is sponsored by the New York State Department of Transportation in support of statewide air-quality efforts, and we also believe in what they are doing.
Zipcar teams up with RightRides For Women's Safety, Inc. to build safer communities by helping to end harassment and sexual assault. With the use of Zipcar, RightRides flagship program offers women, transpeople and gender queer individuals a free, late-night ride home to ensure their safe commute to or through high-risk areas. They also work towards achieving their goals through their SafeWalk program, community organizing and other programs, as well as fostering greater safety awareness and individual empowerment in their related educational programs.
Since its inception in 1957, YAI/National Institute for People with Disabilities Network is the national leader in education and training in the field of developmental and learning disabilities. The YAI/NIPD Network is committed to fulfilling their long-time mission of building brighter futures for individuals with disabilities and their families.
national partners
StartingBloc is dedicated to supporting young professionals interested in using business as a tool for social change. Through their fellowship program, StartingBloc works with college students and recent grads to give them the tools to help drive social, economic, and environmental innovation throughout their careers. They partner with businesses, universities, and other organizations that set an example as a force for creating both profit and positive social change. We are proud to support StartingBloc!
Connect with a community that shares your passion for all things green. Your Garden Show is a social network for gardeners, by gardeners that connects greenthumbs with knowledge, tools and resources for sharing inspiration, best practices for sustainability and real-time environmental observation. They believe that more (and better) gardeners help build stronger local communities. And we happen to agree.


text:
Sale ends 4/24/17. Excludes select manufacturers.
Min. purchase $199.
Sustainable Threads at ATGStores.com
Authorized Dealer
Sustainable Threads
Save on all Sustainable Threads products
Return to TopLearn more about Sustainable Threads
ATG Stores.com is the best place to shop for Sustainable Threads products
Sustainable Threads is a fair trade, eco-focused company, promoting hand crafted life style products.We work in partnership with low income artisan communities in India, with a special focus on women, to provide marketing opportunities for their products.We work to provide these artisans access to fair wages, larger markets and secure, sustainable livelihoods.We collaborate closely with these artisan cooperatives and groups in order to develop mutually-beneficial and long term trade relationships. These relationships allow us to offer customers beautiful and meaningful high quality products. We are approved members of "Fair trade Federation & Green America".
Related Products


text:
Element Full Coverage T-shirt Bra
Item "#736046
fresh ideas
Natori Element Full Coverage T-shirt Bra (736046):
- Delicate animal print
- Memory foam pads mold to your body for an individual fit and natural look
- Embossed printed liner is laminated to the foam for a sleek, seamless look
- Embossed foam center for optimal comfort
- Convertible straps can be worn regular or criss-cross for added support and wardrobe versatility
- 3 column, 2 row hook and eye back closure
- Full fit coverage
A t-shirt essential, update your bra wardrobe with the Element Bra from Natori. Designed with soft memory foam, it molds to your body for an individual fit and natural look. Straps can be worn traditional or criss-cross for versatility.
Materials (fabric): 76% nylon, 24% spandex; (mesh): 87% nylon, 13% Lycra; (memory foam pads): 100% polyester


text:
Pets in Seattle
Even those who aren't crazy about animals will admit that pets occupy a special place in their owners' hearts and deserve to be treated with as much pampering as possible. Seattle pets services include pet grooming salons, pet sitting, pet daycare and parks, and even pet health insurance. Local dogs and cats have sure come a long way from the days when their only trip was to the veterinarian.
Popular PetsCategories | Add Your Listing
Popular Businesses
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61st Ave SE at 226th St SE
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3215 NE 143rd St
Heart 2 Heart Pet Care
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text:
Billie Joe Armstrong
Osheaga Diary, Day 3 by Mark LepageOh. Hello, Victory. On a night when a reunited Westerberg and Stinson celebrated a legacy and Lorde confirmed her preternatural powers, Arctic Monkeys ran the anchor leg of a ridiculously ...
New music review: Foreverly, Billie Joe Armstrong and Norah Jones (Warner Music Canada)Photo courtesy of Warner Music Canada Kudos to Billie Joe and Norah for covering all of Songs Our Daddy Taught Us, an Everly Brothers album recorded well before the pop-punk ...
New music review: ¡Dos!, Green Day (Warner Music)Photo by Felisha White; courtesy of Warner Music Canada; left to right: Tré Cool, Billie Joe Armstrong, Mike Dirnt Bookended by gentle, stripped-down, `50s-styled songs with nothing but soaked-shirt rock ...