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Feb. 27, 2014
LOGAN, Utah - Utah State gymnastics is set for the second of four-straight home meets this weekend as it hosts Sacramento State. The Aggies welcome the Hornets to the Dee Glen Smith Spectrum on Friday, Feb. 28 at 7 p.m.
Friday's meet is HURD Night. In appreciation for the Utah State student section, drawings will be held between each rotation for students to win prizes provided by the HURD. Friday is also Faculty and Staff Appreciation Night. Each Aggie gymnast has selected a professor or mentor who will be announced and recognized during the USU march-in at the beginning of the meet. All Utah State faculty and staff can purchase their ticket to the meet for $3.
Friday's meet will be streamed live and at no cost for fans. Additionally, live scores will be available. Links to both will be posted on the Utah State Athletics website on Friday. Fans can also follow the Utah State gymnastics social media outlets for meet updates.
This week, Utah State is ranked No. 35 in the Troester/Gym Info rankings with a Regional Qualifying Score of 194.315 and an overall record of 6-7. The 35th spot is the highest ranking the Aggies have held since the week of Jan. 17, 2011. Sophomore Miranda Kerr leads the team on vault with a personal RQS of 9.820, senior Paige Jones holds the top spot on bars with a 9.780, freshman Charly Belliston leads on beam with a 9.730, while McIntire is the floor leader with a 9.840.
The Aggies are coming off a strong performance against No. 18 Denver last Friday. Utah State notched a 48.475 on vault, 48.900 on bars, 48.100 on beam and a season-high 49.175 on floor, contributing to the 194.650 total. Freshman Bailey McIntire claimed her fifth event win, taking the floor title with a career-best 9.900.
Sacramento State comes to Logan with a 4-11 record and an RQS of 193.445. The Hornets notched a season-best 194.900 two weeks ago in a tri-meet against California and San José State. Sacramento State is led by junior Kalliah McCartney who is averaging a 38.592 in the all-around. Kim Hughes is in his 31st year at the helm of the Sacramento State program, with Randy Solorio (26th season) and Tanya Ho (second season) as his assistants. As former members of the Western Athletic Conference, Utah State and Sacramento State have a long history of competition. The Hornets lead the all-time series, 14-7. USU is 2-5 at home, 1-5 in Sacramento and 4-4 at neutral sites.
The Aggies will continue the month-long homestand next week, hosting former WAC rival San José State. The March 7 meet will start at 7 p.m. in the Dee Glen Smith Spectrum. That weekend will be the annual alumni celebration. All returning Aggie gymnastics alumni will be recognized at the meet, while there will be a mixer that night and a banquet the following afternoon.
For USU gymnastics ticket information, contact the USU Ticket Office at the Dee Glen Smith Spectrum, by phone by calling 1-888-USTATE-1 or (435) 797-0305, or online 24 hours a day at www.UtahStateAggies.com.
Fans can follow the USU Gymnastics' Twitter, Facebook and Instagram pages - Twitter:@USUGymanstics, Facebook: Utah State Gymnastics and Instagram: @USUGymanstics. Aggie fans can also follow the Utah State athletic program at twitter.com/USUAthletics or on Facebook at Utah State University Athletics.
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In this case, San Francisco-based peer-to-peer car-sharing company Wheelz, which launched a year ago at Stanford University, is adding four LA-area colleges to its stable of locations. Wheelz is expanding to Pomona College, Loyola Marymount, Cal Tech and Occidental College. The company already has operations at UCLA and USC, in addition to UC Berkeley.
Unlike traditional car-sharing companies like Zipcar, which owns its fleet (and have invested in Wheelz), Wheelz lets people rent their own vehicles and arranges the reservation systems as well as insurance. The company says the average car owner generates about $250 a month through Wheelz rentals.
In February, Wheelz received $13.7 million in funding from Zipcar, and its investors include Fontinalis Partners, which was founded by Ford executive Bill Ford. There are other peer-to-peer car-sharing networks, including companies like Getaround and RelayRides,. Check out Wheelz's press release below.
SAN FRANCISCO, CA. – September 25, 2012 Wheelz, the peer-to-peer (P2P) car sharing service that is revolutionizing car ownership and access, announced today that it is launching across four new college campuses in Los Angeles. Wheelz connects students with cars to students who need them and is doubling the number of California college campuses it serves after seeing great traction at Stanford, UC Berkeley, USC and UCLA. By offering a convenient and easy-to-use car sharing solution, Wheelz is filling an important need for students in L.A., who really need a car to access the amazing business, cultural and entertainment options that surround them.
Pomona College, the founding member of the Claremont Colleges, has agreed to officially endorse the program, providing a convenient and reliable transportation option for exploring the city to students at Pomona, Claremont McKenna College, Harvey Mudd College, Scripps College, Claremont Graduate University and Keck Graduate Institute. In addition to the Claremont Colleges, Wheelz is currently launching at Loyola Marymount, Caltech, and Occidental.
Through a seamlessly integrated system of smartphone apps, website and in-car DriveBox TM technology, Wheelz delivers a trusted and hassle-free peer-to-peer car sharing experience. Car owners simply post when their car is available for rent; renters can reserve and instantly access vehicles using either the Wheelz smartphone app or a Wheelz DriveCard. This means renters can unlock Wheelz cars and never have to meet up with the car owner in person to get the keys-the technology takes care of it all. At Stanford, in just the last school year, thousands of students became Wheelz members. The company expects students in L.A. to show rapid adoption as well.
"Car ownership is no longer a priority for millennials; this generation cares about convenience and access," said Wheelz CEO, Jeff Miller. "We've built and refined our service on college campuses because today's students are at the forefront of the shared economy. The result is that we've created the simplest and most efficient P2P car sharing service available anywhere, solving the traditional problems like unreliability and high levels of friction."
While car borrowers get where they need to go to run errands, go on a date, attend interviews or take a trip off campus, car owners earn cash by putting their cars to work. So far, car owners earn an average of $250 per month by renting out their car through Wheelz and can earn as much as $1,000 per month. In addition to letting students earn cash to help with car payments and tuition, Wheelz helps lighten the economic impact of car ownership, alleviating traffic and parking congestion, and reducing environmental impacts.
For Pomona College, "Wheelz offers another way for our students to explore the region beyond our campus, pursue internships, and take advantage of LA," says Miriam Feldblum, Vice President and Dean of Students at Pomona College. "Even better, it is a sustainable, affordable, and accessible solution and is a great complement to our other transportation options, including Zipcars, the Sagecoach and public transportation."
Car owners can turn their vehicle into a cash-generating machine, while having complete peace of mind thanks to Wheelz' innovative permissioning system. Courteous and punctual renters get higher ratings and car owners select whom they feel comfortable sharing with, maintaining complete visibility and control. Car owners may approve every new renter, automatically building a secure network of trusted peers, so they can make more money with more rentals and less hassle.
Universities interested in providing students with a new student-driven transportation option through Wheelz should contact Phillip Carter at email@example.com. To learn more about Wheelz, or to start sharing or renting your car today, visit http://www.wheelz.com/.

subset: commoncrawl


text:
The NEC Jazz Composers' Workshop Orchestra features NEC students performing NEC student–composed works, under the direction of Frank Carlberg.
Jeff Michaels Mental Peace
soloist: Kazemde George, soprano saxophone
Kazemde George Redi's Dilemma/Life Flows On/Souled Out
Kai Sandoval, trumpet (Redi's Dilemma)
Kazemde George, tenor saxophone (Life Flows On)
samples used:
in Redi's Dilemma: "Ready for Love" from The Main Ingredient's album Ready for Love (1980)
in Life Flows On: "Mixed Emotions" from Chris Connor's album I Miss You So (1956)
in Souled Out: "Theme from Shaft" and "A Friend's Place" from Isaac Hayes's album Shaft (1971)
"Ain't No Sunshine" from Isaac Hayes's album Wattstax—The Living Word (1972)
"The Look of Love" from Isaac Hayes's album …To be Continued (1970)
In the 1940s and 1950s, Jazz innovators such as Charlie Parker, Thelonious Monk, and Bud Powell began to use popular dance music and Broadway songs as the basis for a new style of improvisation: Be-Bop. They used these simple forms and harmonies, and the constant beat, as a springboard for improvisations that took the music out of the sole realm of entertainment and into the sphere of intellectual art-music. Throughout the history of Jazz, popular dance music and many other contemporary musical influences have been important reference points in the music's development.
This concept of using existing material as the starting point for creating something new was later applied in the context of Hip-Hop in the 1980s and 1990s. Young black artists in New York City began making music that utilized previously recorded material from their parent's vinyl collections to create new loops and textures that would be arranged into a beats, which a rapper or poet could improvise over, or a break-dancer could dance to. Producers such as J Dilla, DJ Premier, Dr. Dre, and Pete Rock mastered this process of using recorded samples as their materials, and found ways to create music that was truly novel.
This project brings some of this modern Hip-Hop approach to the Jazz big band. I have taken beats that I created by arranging, editing, and altering recorded samples in Logic Pro, and transcribed and arranged them for live instruments. This is my way of bringing Hip-Hop, which already draws so much from Jazz, back to its roots.
Utar Artun Overdub in 7 Takes
Sarah Hughes, alto saxophone
Jeff Michaels, trumpet
Overdub in 7 Takes's title presents the leitmotif (melody) of the tune. The story tells us the hard moments of a recording producer during the overdubbing session of the tune. The melody loses one beat in every exposition. Re-expositions are varied with different orchestrations, harmonies and counter melodies. It starts in 7/4 then turns into 6/4 and 5/4. There is an odd time—7/8 section—which is the B part of the tune. This section has the Turkish maqam "hijaz" without microtones. It's similar to a mix of harmonic minor and Dorian b5 scale. The music is based on a Sonata Allegro form with improvisation sections. Essential of groove is focused on bass and drum parts/riffs.
Lorenzo Marquez Negro Pálido
Henrique Eisenmann, piano
Russell Holzman, percussion
Felipe Durán, percussion
Peter Jonatan Hymn of Hope
soloist: Kazemde George, tenor saxophone
Hymn of Hope is a piece inspired by the simple, yet elegant melody of hymns. The main theme first appears in chorale-like setting and then it develops into 6/8 afro-cuban rhythm. Some transitional rhythmic figures throughout the piece are derived from the polyrhythmic nature of the 6/8 afro-cuban rhythm. The tune is episodic, with contrasting sections of diatonic and chromatic harmony. Section A has the main theme with diatonic harmony, whereas section B has the development of the main theme with chromatic harmony and tonality moving in 3rds.
Steve Bass Excerpts from Swan Lake
Will Bridges, alto saxophone
Kazemde George, Kevin Sun, tenor saxophone
Aaron Bahr Lamb
Kazemde George, tenor saxophone
Jonathan Gaines, trumpet
For a composer, it is always interesting to take material that is very familiar to most people and change its context in order to surprise the listener. In this piece, I have taken the well known children's song "Mary Had a Little Lamb," and transformed it by changing its rhythmic and harmonic context.
The piece also breaks the melody down into smaller melodic samples which are developed on in various ways.
Chase Morrin Settling Grise Fiord
soloist: Kevin Sun, tenor saxophone
In this piece, I hoped to explore some of the raw orchestrational elements of the big band. Not only does this piece develop the motifs in a slightly unconventional way, but it also draws a lot of inspiration in terms of phrasing and timbre from outside of the jazz idiom. Grise Fiord is a remote city in Nunavut, Canada.
Mariel Austin The Erratic Dances of Lower Manhattan Turnstiles
Kazemde George, soprano saxophone
Gabe Gladstein, violin (guest soloist)
Joe Ricard Stale Marshmallows
Thiago Gomes, guitar
Kazemde George, tenor saxophone
Will Bridges, soprano saxophone
Jenn Allen Cosmic Dreams
Henrique Eisenmann, piano
Will Bridges, soprano saxophone
Kai Sandoval, trumpet
the setting sun
(easing out of day
in her twilight dance)
rests cheek against Earth
and dreams (in gold)
Inspired by Six Dances in Bulgarian Rhythm from Béla Bartók's Mikrokosmos
Jazz Composers' Workshop Orchestra
Frank Carlberg, director
Henrique Eisenmann, assistant
Will Bridges, alto saxophone
Sarah Hughes, alto saxophone
Kevin Sun, tenor saxophone
Kazemde George, tenor saxophone
Daniel Sagastume, baritone saxophone
Kai Sandoval
Jon Gaines
Jenn Allen
Jeff Michaels
Elmer Churampi
John Cushing
Eric Stilwell
Rex Bennett
Mariel Austin
Joe Ricard
Rhythm Section
Henrique Eisenmann, piano
Thiago Gomes, guitar
Neil Patton, bass
Michael Dick, drums
Are you an NEC faculty member or student who is giving a school concert? Submit your artist and repertoire information now!
NEC's FREE concerts do not require a ticket, unless stated in concert listing.
Unreserved seating is available on a first-come, first-served basis.
Doors open 30 minutes prior to the concert's start time.


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This project supports the Government of the Philippines in its efforts to improve the productivity and the competiveness of the agribusiness sector. The project helps farmers improve their economic situation by enhancing their business management skills and financial literacy and by providing them with access to better farming practices and to markets for their products. The project helps farmers gain greater access to finance by working with financial institutions to develop financial products and services that meet their needs. It also aims to increase investment in the agribusiness sector by facilitating partnerships between the government and the private sector on agriculture-related infrastructure projects. It also helps government design new/enhanced policies, regulations and procedures that lower the transaction costs of farmers and agriculture enterprises. Finally, the project aims to improve the laws and regulations that govern the sector by eliciting significant input from the private sector on key reform areas affecting agribusiness, through dialogues that bring representatives from the government and the private sector together.
The expected intermediate outcomes of this project include: increased investments in agriculture and the agribusiness sector; reduced compliance and transaction costs for farmers and the agribusiness sector; and improved incomes of smallholder farmers.
Results achieved as of December 2014 include: Partnership arrangements forged with key agencies (Department of Agriculture, Department of Transportation and Communication) and financing institutions (CARD SME Bank, Rizal Micro Bank). IFC also signed a Cooperation Agreement with lead firm Bayer Cropscience to help improve farm productivity and increase farm income through good agronomic and business practices. A Cooperation Agreement was also signed with CARD-Pioneer Microinsurance Inc. (CP), a new joint venture company formed by CARD MRI Insurance Agency Inc. and Pioneer Insurance and Surety Corporation to develop and deploy insurance products to address typhoon-related risks faced by both lenders and farmers. These arrangements have enabled IFC to start its advisory services to these clients which resulted in modest outcome-level results in terms of loan disbursements to agriculture clients, conclusion of the first Post Harvest Processing and Trading Centre Asset Purchase Agreement, and completion of two regulations in domestic shipping reform – (1) the streamlining of the ship licensing process and (2) reducing barriers to market entry of new firms - were completed in March 2014. Both these reforms significantly shorten the average processing time for licensing vessels (from an average of 40 to 20 days), and an estimated cost savings of up to US$ 300,000 for each large vessel.
These results are contributing to increasing investments in the agriculture and agribusiness sector, reducing compliance and transaction costs in the agribusiness sector, and improving gross margin of women and men smallholder farmers.
Information not available
|Recipient Name
|IFC - International Finance Corporation


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Once the head accessories designer at Marc by Marc Jacobs, where she created some of the most coveted bags of the decade - she continues to work there as a creative consultant - Hillier is now the expertise behind Victoria Beckham's phenomenally successful bag line, and a consultant for Henry Holland's House of Holland label and for designer Stuart Vevers, with whom she recently collaborated to re-imagine Loewe's iconic Amazona tote bag.
A British Fashion Awards winner, Hillier's past employers include Stella McCartney, Jonathan Saunders, Gap and Luella Bartley. The 37-year-old Greenford-born designer, who lives in Victoria Park, has also launched her own eponymous line, a fine jewellery collection, designed to encapsulate her trademark "luxury with a wink" approach.
"I do love what I do," says Hillier as we sit down a stone's throw from her studio at Shoreditch's Rochelle Canteen. The fair-haired designer has found a spare hour in a hectic schedule that involves her spending "most weekends" in the studio, 10 days a month in New York and "never ever" seeing her boyfriend who, incidentally, is Patrick Grant, the designer behind successful menswear line E Tautz.
"I've got to a position now where I'm very happy with all the things I'm working on, they're all amazing in their own ways."
Even Victoria? Hillier started work on Beckham's luxury bag line two years ago. The beautifully crafted line of accessories - with a price tag in excess of £2,300 - is reported to have helped the label rake in some £15 million in the first three months of this year.
"Victoria is super-smart," says Hillier, who has been impressed by the former Spice Girl's attention to detail. "People need to rethink their opinion of her, she knows a lot about handbags. In fact, she knows a lot about everything to do with fashion. Working with her is not only really good fun, it's satisfying because the product is so amazing."
The appeal of Hillier's work for Beckham is its subtlety. While the accessories world is littered with heavily branded tote bags, Beckham's range is free of fuss - the bags don't even feature a logo.
"It's hard to design a bag that speaks for itself," says Hillier. "With Victoria, it's all about the quality. I get emails from her saying, 'The little inside pocket doesn't have the right stitching.' Our focus isn't on designing a logo but on finding the right leather. I enjoy working on something that I know means something."
Hillier's journey was a long, occasionally bumpy one that saw her dip into almost every aspect of the fashion industry before arriving in her role as the UK's most exciting handbag designer. After completing a BTEC course at Hounslow College, Hillier went to the University of Westminster's campus in Harrow where visiting lecturers included John Galliano and Clements Ribeiro. It was during this time that she met Love Magazine editor and stylist Katie Grand, for whom she later worked at Dazed & Confused.
"I made Katie a keyring out of beads for her birthday," says Hillier, "and she loved it and was keen to see what else I could do."
As a result, Hillier created a series of beaded belts for a shoot Grand was doing with Sharleen Spiteri. "The rest," she says, "is history."
Luella Bartley's label was just taking off when Hillier scored a job as her assistant. "I learned so much. We did the press together, the sales, I even produced the shows." Hillier seems to have learned from Bartley's errors - the label had to close with financial trouble in 2009. "We had an amazing time of growing and making terrible business mistakes because we didn't know any better."
After Bartley was forced to "let her go", Hillier worked for Marc Jacobs - she describes him as a genius - where she has been for nine years.
But it is on the subject of growing her own label that Hillier talks most passionately. "I get the highest design satisfaction out of Hillier because it's what we want to do. You don't compromise on design."
While the current collection - fine jewellery focused on her love for bunnies - remains a small venture, Hillier has plans for her own line of bags, wallets and sunglasses. Although she remains tight-lipped, "watch this space," she says, her eyes twinkling. "I think - in fact I know - I've got the headspace to do it all." For the sake of handbag lovers everywhere, I certainly hope so.Reuse content


text:
2Wheeler, 3 Wheeler, 4wheeler… etc
Wheel Chair
Pramod harithsa wrote:does this [^]help?
Pramod harithsa wrote:google and Search by image
_AK_ wrote:And indeed it is terrible.
Pramod harithsa wrote:When you try so much to view a terrible stuff.. it makes it more terrible than
it was supposed to be !
_ Kunal Chowdhury _ wrote:you will "like" them:
Arzz kiya heyRoz subha hum karte hai Itne pyar se unhe good morning...
Woh humhe ghoor kar dekhte hain Jaise 0 ERRORS but 5 WARNINGS...
Ek aurMere... Company kee ladkiyaan sunder hain Aur lonely hain...
Problem ye hai ki bus voh READ-ONLY hain...
_ Kunal Chowdhury _ wrote:Good one.
_ Kunal Chowdhury _ wrote:Share more...
Pramod harithsa wrote:You will have them flowing soon. .
Pramod harithsa wrote: 0 ERRORS but 5 WARNINGS
Prerak Patel wrote:That was my
first message[^] in GIT
_AK_ wrote:Why you deleted that.
Pramod Harithsa wrote:That probably was not the right reply i wanted to post.
"Before you start some work, always ask yourself three questions - Why am I doing it, What the results might be and Will I be successful. Only when you think deeply and find satisfactory answers to these questions, go ahead." by :chanakya
General News Suggestion Question Bug Answer Joke Praise Rant Admin
Use Ctrl+Left/Right to switch messages, Ctrl+Up/Down to switch threads, Ctrl+Shift+Left/Right to switch pages.


text:
Reconciliation of Data on Infusions with Temporally Associated Adverse Events - Hizentra, February 26, 2010
Clinical Review Memorandum
Date: February 26, 2010
To: To File (BLA STN 125350/0)
From: Hon-Sum Ko, Medical Officer, HFM-392
Through: Nisha Jain, Acting Branch Chief, HFM-392
CC: Pratibha Rana, RPM, HFM-370
Applicant: CSL-Behring
Product: Immune Globulin Subcutaneous (Human), (IGSC, 20%; IgPro20)
Trade name: Hizentra®
Subject: Reconciliation of Data on Infusions with Temporally Associated Adverse Events
CSLB's BLA on Immune Globulin Subcutaneous (Human), 20% Liquid, (IgPro20, Hizentra) was submitted on 4/30/09. At the mid-cycle review, an Information Request was conveyed to CSLB on 10/23/09, and one of the items (#8) involved infusional adverse events (AEs):
8. Please conduct an analysis of the ratio of the number of infusions with temporally associated adverse events (from start to within 72 hours of the end of infusion) to the total number of infusions, including point estimate and 95% confidence intervals.
CSLB Response on 11/12/09 (Amendment 4). The requested confidence intervals, under inclusion / exclusion of ISRs, are provided in Table Q8.1 in Attachment 6. Confidence limits (CL) were calculated with the same method as described for the rate of infections in the Statistical Analysis Plan (Poisson based CL).
During the discussions on labeling for the package insert with CSLB, it became clear that the data presented in Table Q8.1 of Amendment 4 were not on the ratio of number of infusions with adverse events to all infusions, but rather the rate of infusional adverse events.
CSLB was asked to resubmit Table Q8.1 with proper information. CSLB did so with a submission on 2/22/10.
Revised Table Q8.1
In the revised Table, the number of infusions with AEs has been presented, and may be summarized as follows:
|Total no. of Infusions N=2264
|Including local reactions
|Excluding local reactions
At least possibly related AEs
Serious AEs
At least possibly related serious AEs
Temporally associated AEs (24h)
Temporally associated AEs (48h)
Temporally associated AEs (72h)
At least possibly related, temporally associated AEs (48h)
At least possibly related, temporally associated AEs (72h)
Serious at least possibly related, temporally associated AEs (72h)
AEs, where study drug infusion had to be stopped
At least possibly related AEs, where study drug infusion has to be stopped
AEs leading to withdrawal of the subject
At least possibly related AEs leading to withdrawal of the subject
AEs leading to the death of the subject
At least possibly related AEs leading to the death of the subject
|1396 (0.617)
1308 (0.578)
9 (0.004)
1170 (0.517)
1328 (0.587)
1338 (0.591)
1300 (0.574)
1303 (0.576)
1 (<0.001)
1 (<0.001)
2 (<0.001)
1 (<0.001)
|290 (0.128)
69 (0.030)
9 (0.004)
116 (0.051)
140 (0.062)
173 (0.076)
51 (0.023)
56 (0.025)
1 (<0.001)
Thus, the ratio of infusions with temporally associated AEs (during and up to 72 hrs after the end of infusion), including local reactions, was 1338/2264 (59.1%) with 95% confidence interval of 56% and 62.4%. Excluding local reactions, the corresponding ratio was 173/2264 (7.6%) with 95% confidence interval of 6.5% and 8.9%.
The information is incorporated into labeling. The draft package insert package insert accepted by CSLB as of 2/25/10 is attached to this memo.
This memo corrects my interpretation in the Final Review Memo on BLA STN 125350/0 (dated February 16, 2010) Section 7.1, regarding infusional adverse events presented in Amendment 4.


text:
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Jornal de Pediatria
Print version ISSN 0021-7557On-line version ISSN 1678-4782
J. Pediatr. (Rio J.) vol.84 no.4 suppl.0 Porto Alegre Aug. 2008
Impact of genetics in childhood asthma
Leonardo A. PintoI; Renato T. SteinII; Michael KabeschIII
de Pesquisas Biomédicas, Pontifícia Universidade Católica
do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. Programa de PósGraduação
em Saúde da Criança e do Adolescente, Universidade Estadual de
Campinas (Unicamp), Campinas, SP, Brazil
IIDoutor. Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, RS, Brazil
IIIChildren's Hospital, Ludwig Maximilian's University of Munich, Munich, Germany
To present the most important and recent results of studies on asthma genetics.
These data may help general physicians understand the impact of genetics on
this complex disorder and how genes and polymorphisms influence asthma and atopy.
SOURCES: Data were collected from MEDLINE. Genetic association studies were selected from the Genetic Association Database, which is an archive of human genetic association studies of complex diseases and disorders organized by the National Institutes of Health.
SUMMARY OF THE FINDINGS: Considering the data from several important twin studies on asthma genetics, heritability, which measures the contribution of genetic factors to the variance of asthma, may be estimated in 0.480.79. A huge number of genetic association studies have been trying to identify asthma susceptibility genes. The most replicated results in the genetic association studies involve the following five regions of the human genome: 5q3132, 6p21, 11q1213, 16p1112, and 20p13. Only recently a new asthma susceptibility gene (ORMDL3) has been identified by a whole genome association study, considered to be a major determinant for childhood asthma.
CONCLUSIONS: Genetic contribution to asthma may be estimated ranging from 48 to 79%. Several loci seem to influence asthma susceptibility. Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be determinants of childhood asthma. Diagnostics and pharmacogenetics may be the first clinical implication of extensive studies on asthma genetics.
Keywords: Asthma, genetics, childhood, pharmacogenetics.
It has been recognized that asthma is of hereditary nature, but that inheritance does not follow the classical Mendelian patterns in this disease. Several family studies have showed evidence of a substantial familial aggregation pattern in asthma.1,2 However, the asthma genetics is especially complicated by its polygenic nature and due to the interaction between genetic and environmental factors.3 A better understanding of the genetic mechanisms of both asthma and allergy will enhance our knowledge of their pathophysiology, and represents an important advance for further efforts towards prevention and treatment.
Some aspects of this field of basic research may directly influence our clinical practice. The genetic determination of allergic responses to environmental stimuli and the role of pharmacogenetics in the management of asthma are highly regarded research topics.4 The mapping of complex traits such as asthma is one of the most important areas of research in human genetics.
Although it is known that genetic susceptibility contributes to the risk of asthma, only few linkage or association genetic studies have been performed in nonEuropean populations. Some studies have shown evidence of genetic control that differs between ethnic groups.5,6 However, this evidence is scarce and further studies on asthma genetics in nonEuropean populations are necessary and may help to determine worldwide differences in the role of genetic variations in the development of asthma and allergies.
A classic design to study the impact of genetics on complex traits and to distinguish between genetic and environmental influences is the study of twin pairs, in which the concordance between monozygotic (MZ) and dizygotic (DZ) twins is compared. MZ twins share 100% of their genetic makeup and DZ twins share in average 50% of their genes. These studies allow for calculation of asthma heritability (h2). In genetics, heritability is the proportion of phenotypic variation in a population that is attributable to genetic variation.7 It estimates the relative contribution of genetic and nongenetic factors to the total phenotypic expression in a population.
Twin studies in asthma genetics
If genes influence a particular trait, MZ twins, due to their greater genetic similarity, should share that trait more than DZ twins. An Australian study investigated 3,808 twin pairs,8 and the correlations for asthma were greater for MZ twins than for DZ twins (0.48 for MZ, 0.09 for DZ, male; and 0.33 for MZ, 0.12 for DZ, female) implying a significant proportion of the variance accounted by genetics in asthma pathogenesis (h2 = 0.60). Duffy et al.9 reanalyzed the 3,808 Australian twin pairs in 1990, and the correlation of self reported asthma was 0.65 in MZ twins and 0.24 in DZ twins. Heritability was estimated in 0.60 for females and 0.75 for males.
Nieminen et al.10 published a large populationbased study of > 13,000 adult Finnish twin pairs. The diagnosis of asthma was performed by linking the twin registries with databases on hospital admissions and utilization of medication. Data were collected from a central office for epidemiology. A total of 4,307 MZ and 9,581 DZ twin pairs aged 1870 years were included. The heritability estimation was 0.68 for women and 0.48 for men (aged 2859 years). In this study there was a marked gender difference in heritability and there was a difference in heritability between the various age groups, with heritability decreasing with age, which is in accordance with the clinical and epidemiological evidences.
Another twin study published in 1997 included 1,480 Swedish twin pairs aged 79 years (from the Swedish Twin Registry).11 All twins born in Sweden between 1985 and 1986 were given a detailed asthma questionnaire. The correlation for parentalreport of asthma was 0.79 for MZ male twin pairs and 0.64 for MZ female pairs, with correlations of 0.25 and 0.27 for DZ male and female pairs, respectively. The contribution of genetic factors to variance of asthma in this study was about 0.76 for boys and 0.64 for girls.
In a Norwegian study, all twins born between 1967 and 1974 (5,864 children) were identified through the Norwegian National Birth Registry.12 The prevalence of selfreported asthma was around 5% and there were no significant sex differences. The concordance for asthma was 0.45 for MZ twins and 0.12 for DZ twins. This study showed that genetic effects explained 75% of the variation in both sexes. The remaining 25% was accounted for by environmental influences.
Another Finnish twin study in 16yearold twins and their parents presented combined twinfamily data on asthma genetics. The heritability of asthma was approximately 79% and the remaining 21% were due to environmental influences.13 If only the families with parental asthma were considered, genetic influences explained as much as 87% of the development of asthma in the offspring.
Another largescale study on 11,688 twin pairs aged 1241 years was published in 1999 and the heritability was estimated in 0.73 (Danish population sample).14 A more recent twin study with an estimation of asthma heritability was published in 2001.15 This last asthma twin study estimated a heritability of 0.68 in a population from the United Kingdom.
All these twin studies have shown the importance of the genetics on asthma variance, with results of heritability estimation ranging from 4879%. An important finding is that most of these twin studies in different parts of the world (especially in Northern Europe) showed similar and consistent results and stress the fact that especially childhood asthma has a strong genetic background. Table 1 presents the summary of these important populationbased twin studies.
Although we can estimate to what extent genetic susceptibility contributes to the risk of asthma, the specific loci that influence the clinical phenotypes are yet far from being clearly identified. A significant number of genetic association studies have been describing asthma susceptibility genes, but these data demonstrate the extreme complexity of the disease, and the identification of these genes and polymorphisms may be still considered a difficult challenge.
Candidategene association studies
A widely used approach for the identification of asthma susceptibility genes is the study of polymorphisms in candidate genes. Genetic association studies test whether a specific genetic variant is more common in asthmatics than in nonasthmatics. Controls for association studies should be recruited from a population that shares ethnic or geographic similarities with the cases. The advantages of association studies include their power to detect susceptibility genes and their applicability to the general populations. This approach is powerful if (and only if) the candidate selected for the study is clearly involved in the pathogenesis of the disease.16
However, because of the multitude of potential candidate genes for a complex trait, the work involved in a comprehensive candidategene approach might be overwhelming. In addition, as it is now recognized, results of individual polymorphism studies may be misleading (especially because of linkage disequilibrium), thus the candidategene approach has to include multiple variants that are evaluated simultaneously. Considering this, correction for multiple comparisons or replication in different population samples and/or functional analysis have been required to define causality in these association studies.17,18
Several candidate genes (> 100 loci) have been proposed and studied in asthma. Several factors contribute to this abundance of candidates. Results from genome screens have provided evidence of linkage to multiple sites in the genome. Therefore, there are many positions including several candidate genes. In addition, immunological pathways associated to the asthmatic response involve a large array of inflammatory mediators such as cytokines and chemokines. However, the best replicated results in the genetic association studies involve the following five regions of the human genome: 5q3132, 6p21, 11q1213, 16p1112, and 20p13 (http://geneticassociationdb.nih.gov).19
Genetic Association Database
The Genetic Association Database (GAD) is an archive of human genetic association studies of complex disorders, organized by the National Institutes of Health (http://geneticassociationdb.nih.gov). The objective of this database is to allow the researchers to rapidly identify medically relevant polymorphisms from the large volume of gene variations, in the context of a standardized nomenclature for genes and polymorphisms (rs numbers). The database includes selected published scientific papers. Study data is recorded with the official nomenclature used for the human genome. If a study investigates more than one gene for a particular disorder, there will be more than one record. The submitted records are reviewed before inclusion in the database.19
Using GAD, we have selected eight genes, located in the five above mentioned regions of the genome, for the current review that have been associated with asthma in more than five populationbased genetic association studies. These relevant asthma susceptibility genes are discussed below in detail (Table 2).
Chromosome 5: ADRB2, IL13 and IL4
The beta2adrenergic receptor gene (ADRB2) is a member of the G proteincoupled receptor superfamily. This receptorchannel complex contains a G protein, an adenylyl cyclase and the counterbalancing phosphatase. The assembly of the signaling complex provides a mechanism that ensures specific signaling by this G proteincoupled receptor. Different polymorphic loci of this gene have been associated with asthma diagnosis, nocturnal asthma, asthma exacerbations and response to beta2 agonists in asthma treatment.
Turki found a higher frequency of glycine at position 16 (Gly16, SNP rs1042713), compared to Arg16, in individuals with nocturnal asthma.20 Other evidence has suggested that the presence of Gly16 (aminoacid sequence) of ADRB2 imparts enhanced agonistpromoted downregulation of the type that characterizes this form of asthma.
In a metaanalysis published recently, ContopoulosIoannidis et al. confirmed the association between the Gly16 polymorphism and nocturnal asthma, but found no association between this variant and bronchial hyperresponsiveness.21 Other studies found association between rs1042713 and different responses to beta2 agonists (especially albuterol and salmeterol).22
IL13 encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine upregulates major histocompatibility complex class II (MHCII) expression and promotes IgE isotype switching. IL13 inhibits the production of proinflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergeninduced asthma but operates through mechanisms independent of IgE. IL3, IL5, IL4, IRF1 and CSF2 form a cytokine gene cluster on chromosome 5q, with IL13 located particularly close to IL4.
Howard et al. reported that the promoter variant (C1112T, rs1800925) of the IL13 gene contributes significantly to bronchial hyperresponsiveness and asthma susceptibility but not to total serum IgE levels.23 Heinzmann24 determined that a R130Q variant of IL13 (rs20541) is associated with asthma in casecontrol populations from Britain and Japan (odds ratio, OR = 2.31, 95%CI 1.334.00); the variant also predicted asthma and higher serum IL13 levels in a Japanese pediatric population.
The protein encoded by the IL4 gene is a Th2 cytokine produced by activated T cells that influence allergic immune response. The IL4 receptor also binds to IL13, which may contribute to many overlapping functions of IL4 and IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several regulatory elements on chromosome 5.
Kabesch25 have demonstrated a possible involvement of SNP in the IL4 gene in the development of asthma and the regulation of total serum IgE. In addition, this group has shown in 200626 that especially the combined analyses of genetic alterations in the IL4/IL13 pathway reveal its significance to the development of atopy and childhood asthma. Additionally, other genes harbored in the locus, as CD14 and IRF1, may also contribute to asthma and allergy.
Chromosome 6: HLADQB1 and TNF
HLADQB1 belongs to the human leukocyte antigen (HLA) beta chains. This molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Within the DQ molecule both the alpha and the beta chains contain polymorphisms, leading to four different molecules. Several studies2729 have shown association between HLADQB1 variations and asthma or aspirininduced asthma (Table 2).
The tumor necrosis factor (TNF) gene encodes a multifunctional proinflammatory cytokine that belongs to the TNF superfamily. This cytokine is mainly secreted by macrophages and is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation and apoptosis.
Witte30 evaluated the relation between the G308A (rs1800629) promoter polymorphism of the TNF gene and risk of asthma in 236 cases and 275 nonasthmatic controls. This study indicated that having one or two copies of the 308A allele increased risk of asthma (OR = 1.58), the magnitude of which was increased when restricting the cases to those with acute asthma (OR = 1.86, p = 0.04) or further restricting the subjects to those with a family history of asthma and those of European American ancestry (OR = 3.16, p = 0.04).
Instead, Aoki et al.31 did not find a significant association between this TNF G308A polymorphism (rs1800629) and childhood atopic asthma in two independent Japanese populations; however, metaanalysis of a total of 2,477 asthma patients and 3,217 control individuals showed that the G308A polymorphism was significantly associated with asthma. The combined OR was 1.46 for fixed or random effects (p < 0.001).
Chromosome 11: SCGB1A1 (or UGB; CC16; CCSP)
Clara cell secretory protein (CC16) is a protein primarily expressed in the respiratory tract by nonciliated bronchiolar secretory cells32 and the immunomodulatory activity of CC16 has been well documented. Mice deficient in CC16 expression exhibit a higher susceptibility to lung injury and an excessive inflammatory response.
The CC16 gene was screened for mutations and a polymorphism (A38G, rs3741240) was identified and associated with an increased risk of physiciandiagnosed asthma in a population of Australian children.33 In a study with adults, a moderate risk of asthma was found to be associated with the CC16 38A allele.34 Laing et al. have shown that the 38A sequence was associated with reduced plasma CC16 levels and individuals with lower plasma CC16 levels were more likely to have asthma.34 However, studies with larger population samples are required to confirm this association.
Chromosome 16: IL4R
This gene encodes the IL4 receptor, a transmembrane protein that can bind IL 4 and IL13 to regulate IgE production. Binding of IL13 or IL4 to the IL4 receptor (IL4R) induces the initial response for Th2 lymphocyte polarization. Both IL13 and IL4 are produced by Th2 cells and are capable of inducing isotype classswitching of B cells to produce IgE after allergen exposure.
Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, asthma, or eczema. Howard et al. investigated 5 IL4RA singlenucleotide polymorphisms in a population of Dutch families ascertained through a proband with asthma.35 The authors observed significant associations of atopy and asthmarelated phenotypes with several IL4RA polymorphisms, especially S503P (rs1805015). A significant genegene interaction between S503P in IL4RA and the C1112T promoter variation in IL13, previously shown to be associated with bronchial hyperresponsiveness, was detected. Individuals with the risk genotype for both genes were at almost five times greater risk for the development of asthma compared to individuals with norisk genotypes. These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases a subject susceptibility to asthma.
Chromosome 20: ADAM33
This gene encodes a member of the disintegrin and metalloprotease domain (ADAM) family. Members of this family are membraneanchored proteins and have been implicated in a variety of biological processes including muscle development and neurogenesis. This protein is a transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. This was the first published asthma candidate gene detected by positional cloning.
Van Eerdevegh36 performed a genomewide scan on 460 Caucasian families and identified a locus on chromosome 20p13 that was linked to asthma and bronchial hyperresponsiveness. A survey of 135 polymorphisms in 23 genes identified the ADAM33 gene as being significantly associated with asthma using casecontrol, transmission disequilibrium, and haplotype analyses (p = 0.040.000003). However, these results were not replicated by several other ADAM33 association studies. Studies in Icelandic and UK populations revealed no association when taken in isolation.
Recently, a metaanalysis showed that the rs511898 and rs574174 variants (located on ADAM33 gene) were significantly associated with asthma.37 The additional risk imparted by these variations would account for 50,000 excess asthma cases in the UK alone.
Genomewide association studies
With the completion of the Human Genome Project in 2003 and the International HapMap Project in 2005, researchers have now a set of advanced research tools that may allow identifying genetic contributions to common diseases more easily. These tools include computerized databases containing the reference human genome sequence and a map of human genetic variation. A genomewide association study (GWA) is an approach that involves scanning markers across complete sets of human polymorphisms.
Recently, the first asthma GWA study38 characterized more than 317,000 SNP in the DNA from 994 patients with childhoodonset asthma and 1,243 nonasthmatics, using both family and casereferent panels. The authors showed multiple markers on chromosome 17q21 to be strongly and consistently associated with childhood asthma with a combined p value < 10(12). An independent replication study showed that the 17q21 locus has a significant association with the diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (p = 0.0003) and in 3,301 subjects from the UK's 1958 Birth Cohort (p = 0.0005). This study38 has evaluated the relationship between markers of the 17q21 locus and transcript levels of genes. The SNP (rs7216389) associated with childhood asthma was consistently and strongly associated (p = 10(22)) with transcript levels of ORMDL3, a member of a gene family that encodes transmembrane proteins anchored in the endoplasmic reticulum. Moffat et al.38 concluded that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. In the subset of individuals for whom expression data were available, the T allele of SNP rs7216389 was the marker most strongly associated with disease in the combined GWA (Figure 1).
Conclusions and future perspectives
Several different loci seem to influence asthma susceptibility. Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be major determinants for childhood asthma.
However, there are only a few studies of asthma genetics in Latin America and not many in underdeveloped areas of the world where asthma is highly prevalent. A recent study from the ISAACPhase II group39 has shown that asthma in nonaffluent communities is significantly less associated with allergy in comparison with more socially developed areas.
It is not clear whether the results from genetic studies in European populations can be easily transferred to populations of different ethnicities. Epidemiological genetic studies in Latin America, Asia and Africa are needed to determine the impact of genes and environment in these regions, which may differ dramatically from the findings in population samples from Europe and the USA.
Improvements in diagnostics and pharmacogenetics may be the first clinical implications of these extensive studies on asthma genetics. In a randomized, placebocontrolled study involving 78 patients with mild asthma, 37 with the R/R genotype and 41 with the G/G genotype (rs1042713), Israel22 found that there were significant genotyperelated differences in response to albuterol compared with placebo. Patients with the R/R genotype improved when betaagonist therapy was withdrawn and replaced with ipratropium bromide, whereas those with the G/G genotype did better with regular betaagonist therapy than when it was withdrawn. Genotype at amino acid 16 of ADRB2 significantly affects the response to albuterol. Furthermore, bronchodilator treatments avoiding albuterol may be appropriate for patients with the R/R genotype.22 This is only an example of how genetics may influence our clinical practice in the near future.
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28. Torio A, SanchezGuerrero I, Muro M, Villar LM, Minguela A, Marin L, et al. HLA class II genotypic frequencies in atopic asthma: association of DRB1*01DQB1*0501 genotype with Artemisia vulgaris allergic asthma. Hum Immunol. 2003;64:8115. [ Links ]
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33. Laing IA, Goldblatt J, Eber E, Hayden CM, Rye PJ, Gibson NA, et al. A polymorphism of the CC16 gene is associated with an increased risk of asthma. J Med Genet. 1998;35:4637. [ Links ]
34. Laing IA, Hermans C, Bernard A, Burton PR, Goldblatt J, Le Souef PN. Association between plasma CC16 levels, the A38G polymorphism, and asthma. Am J Respir Crit Care Med. 2000;161:1247. [ Links ]
35. Howard TD, Koppelman GH, Xu J, Zheng SL, Postma DS, Meyers DA, et al. Genegene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet. 2002;70:2306. [ Links ]
36. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002;418:42630. [ Links ]
37. Blakey J, Halapi E, Bjornsdottir US, Wheatley A, Kristinsson S, Upmanyu R, et al. Contribution of ADAM33 polymorphisms to the population risk of asthma. Thorax. 2005;60:2746. [ Links ]
38. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448:4703. [ Links ]
39. Weinmayr G, Weiland SK, Bjorksten B, Brunekreef B, Buchele G, Cookson WO, et al. Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med. 2007;176:56574. [ Links ]
Correspondence: No conflicts of
interest declared concerning the publication of this article. Suggested citation:
Pinto LA, Stein RT, Kabesch M. Impact of genetics in childhood asthma. J
Pediatr (Rio J). 2008;84(4 Suppl):S6875.
Leonardo A. Pinto
Instituto de Pesquisas Biomédicas
Hospital São Lucas PUCRS
Av. Ipiranga, 6690, 2º andar
CEP 90610000 Porto Alegre, RS Brazil
Tel.: + 55 (51) 3384.5104
No conflicts of interest declared concerning the publication of this article.
Suggested citation: Pinto LA, Stein RT, Kabesch M. Impact of genetics in childhood asthma. J Pediatr (Rio J). 2008;84(4 Suppl):S6875.


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One could see him walking with his two daughters, aged three and two, and a smile on his face as they danced on the grass. He had studied sports therapy at a college in the United Kingdom, but now in Sweden, there was a struggle for work and meaning to his life. He had discussed with his wife a desire to get married again and she agreed with the presence of a second wife in the household. But, at night fury at living among the infidels, living among people whose newspapers printed cartoons which mocked the Prophet. How could a good Muslim such as himself allow such terror to be inflicted on the people of his faith. Oh, there was brutality in nations like Egypt which refused to allow the Muslim Brotherhood to be free, but that was a Muslim nation and any true believer knows Muslim nations can kill or oppress, but that was different from western societies which printed cartoons. After all, when it reaches Heaven they will ask what he did about the cartoons.
So, this, as yet, unnamed man blew himself up in Stockholm. Fortunately, he was an incompetent suicide bomber and only one person died. There was little damage to the area, but he is dead. And, two little girls will not longer see their father who is somewhere, but where that locale is, simply is unknown.


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Here we go again.
For the second time in five years, Jay Leno is leaving NBC�s �Tonight Show,� this time in favor of Jimmy Fallon, who takes over on Feb. 17. And Fallon, who will welcome Will Smith and the rock band U2 as his first guests, made sure from the start that this transition would be a smooth � and permanent � one.
�After the whole Conan (O�Brien)-Jay thing went down, I called Jay and told him, �I�m not gunning for your position at all. I�m very happy here at 12:37 a.m. � When you do decide to step down, let�s do it the right way,�� Fallon told reporters at the Television Critics Association press tour on Sunday.
Fallon went on to say that he and Leno spoke via phone often leading up to the change, until one day last year, Leno called to say, �I think this is going to be the year, and I�d love for you to be the next guy.�
Fallon�s reign will begin at midnight after the Winter Olympics. The �Tonight Show� will slip into its regular slot following the local news a week later, with Seth Meyers inheriting Fallon�s old �Late Night� role.
Fallon said the best specific advice he received from Leno about taking over the �Tonight Show� was to double the length of his current monologue to nine or 10 minutes and make it topical. Fallon agreed.
�He told me that people are busy and they may have missed the news, so you have to give them a complete view of the news and make some jokes about it,� Fallon said.
Although Fallon says he�s planning no major alterations for the show, one big change is the venue: He succeeded in persuading NBC to move the �Tonight Show� from Burbank to New York. The show originated in New York, but has been in Southern California since 1972, when Johnny Carson moved it west.
�I think that�s where it should be. You�ve got the lights. Times Square. � The glitz, the glamor,� said Fallon, who promised that the show would make occasional visits to the West Coast.
As for Leno, Fallon hopes he somehow remains in the NBC family.
�The more Jay, the better,� he said. �Maybe he can be the new detective on �The Blacklist.��


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Click on a thumbnail to go to Google Books.
The Last Werewolf (original 2011; edition 2011)
by Glen Duncan
Work details
The Last Werewolf by Glen Duncan (2011)
Top Five Books of 2013 (307)
» 9 more
I really enjoyed the different take on werewolves and vampires, sexy in places and a writing style that really appealed to me.
Good to have a Hollywood-traditional werewolf back, with all the gore and excessive use of the "c" word you could ask for.
Let's hope it's the last.
I posted my review once of this book and it wouldn't leave my currently reading shelf and when I tried to delete it off the shelf it totally deleted my review. So here it is again. I thought this book was boring. The cover said it was terrifying and I didn't think so at all. I was looking forward to a good scare. I wish I hadn't picked it up. I had high hopes for it because it was being listed in my book emails as a book to read. I guess I won't always listen to what is recommended.
Ugh, this was pretty terrible. I kept waiting to care about the protagonist and never did.
It is a horror that never shies from the human side of lycanthropy; it is a disquisition on the nature of werewolf stories; it is a sublime study in literary elegance. It is bloody (and) brilliant.
References to this work on external resources.
Wikipedia in English
Amazon.com Product Description (ISBN 0307595080, Hardcover)Then she opened her mouth to scream—and recognised me. It was what I'd been waiting for. She froze. She looked into my eyes. She said, "It's you."
Meet Jake. A bit on the elderly side (he turns 201 in March), but you'd never suspect it. Nonstop sex and exercise will do that for you—and a diet with lots of animal protein. Jake is a werewolf, and after the unfortunate and violent death of his one contemporary, he is now the last of his species. Although he is physically healthy, Jake is deeply distraught and lonely.
Jake's depression has carried him to the point where he is actually contemplating suicide—even if it means terminating a legend thousands of years old. It would seem to be easy enough for him to end everything. But for very different reasons there are two dangerous groups pursuing him who will stop at nothing to keep him alive.
Here is a powerful, definitive new version of the werewolf legend—mesmerising and incredibly sexy. In Jake, Glen Duncan has given us a werewolf for the twenty-first century—a man whose deeds can only be described as monstrous but who is in some magical way deeply human.
One of the most original, audacious, and terrifying novels in years.
(retrieved from Amazon Thu, 12 Mar 2015 18:02:33 -0400)
Rendered the last of his kind after a colleague's death, two-hundred-year-old werewolf Jake struggles with depression and contemplates suicide until powerful forces that have personal agendas and the power to keep him alive take over his life.
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Metal Roofing Brands
I'm investigating metal roofing for the log home I'm building. Any opinions or recommendations on what brand? I have literature on Fabral but that's about it.
I do mostly copper, so I'm not familiar with all the metal brands. But check out MBCI. https://www.mbcionline.com/shopping/...ageDataDisplay
I always liked Peterson Aluminum Corporation, Pac-Clad, and they sell other metals than just Aluminum.
Also, for budgetarry conscious buyers, Berridge makes a good panel, but get the ones with the better Kynar 500 coating applied.
there are probably companies that will run off panels right on site check your yellow pages atas international is a company iam familiar with .
kynar 500 finish is the top of the line coating
We buy most of our coils and flat stock from http://www.custombiltmetals.com/. We have 4 panel machines and two soffit machines. Having these machines makes it easy to run panels to any length. If you do order panels from a company make sure the measurements are correct. I have seen nice roofs that have an ugly ridge because the panel was the wrong size.
Another company we deal with is http://www.aepspan.com/. Most of these panels we put on commecial buildings though.
Thanks for all the replies! I am limited to the standing seam style since we want to install solar laminate. I'm still debating whether to try the roof myself.
Series 300 by Imetco in Atlanta. Far and away the best engineered SS around
what makes you say that?
For lower-end systems I have a very good relationship with our local custombilt dealer and it is as acceptable a product for those applications as any of the others and more often than not, considerably cheaper. For quality and engineering though, nothing comes close to series 300.
thanks for the info ill have to check it out:)
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Through a series of meetings and guest speakers we learn about art, dance, medicine, history, education, religion and the economy. This is an extensive and intense learning experience built on the foundation of meeting Cubans and creating a meaningful exchange of ideas and information. Explore the old city as we learn about Havana's history and architecture. Meet with farmers and visit an artist community project in the Vinales Valley. See how small private enterprises are growing throughout the island. Converse with students during a visit to the premier art school in the country. Read more »
$4,685 per person, based on double occupancy and including charter air from Miami to Havana. Single room supplement is $450.
Travelers should arrive to Miami the day before any program, so as to ensure making the charter flight to Havana on the first day of the trip. (Airport hotel information will be provided.)
Trip is limited to 25 travelers.
Rob Reiner, Writer, Director, Actor
On political activism, acting, and growing up in Hollywood.
Recorded before a live audience at The Commonwealth Club of California on Feb. 1, 2013.


text:
Let's Plan on February
Alright, lets bring this back in a big way for 2013. I think we shall let the holidays die down a little, I know we have all been super busy.
I am also going to do some research, and see what national book clubs are out there. See if we don't have to reinvent the wheel, and thus we can still choose a book with or without voting participation.
I was also thinking, maybe a series? Anyway, hope you are all doing well. <3
Happy Holidays!


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Dial Up!
Friday, September 27, 2013 7:00 PM
Gotham Comedy Club, New York, NY
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- Show Type: Comedy
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Dial Up comes to Gotham Comedy Club! Having sold out venues all across the country, the hit show is back in New York for a limited time. Featuring comedians from Comedy Central, Sirius XM Radio, VH1, MTV, TruTV as well as on the Late Show with David Letterman.
Brought to you by Executive Lounge Productions
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After relentless attacks on the PM, Australia's Labor Party could confront a leadership spill this week.
On June 24, 2010, Australia's first female Prime Minister, Julia Gillard, was sworn into office by Australia's first female Governor-General, Quentin Bryce. The iconic photographs of that day spoke of an occasion that was a long time coming.
In the three years to have passed since then, Gillard has been the victim of appalling levels of sexism not seen before in Australian public life. With some justification, therefore, she has made her gender a political issue. But has it been a proportional response to the misogynistic attacks meted out, or used simply for her own political gain?
By July, 2011, a Facebook page had been created called "Julia Gillard - Worst PM in Australian history". The iconic photo of the day Gillard was sworn in was now accompanied by obscene suggestions as to what the Prime Minister and the Governor-General would do next.
And in 2012, after cartoons of her naked and wearing a dildo were emailed to all federal parliamentarians, Gillard finally started making public references to the sexism going viral on the internet.
In October she made headlines around the world for her speech to Parliament on sexism and misogyny.
Many in the Australian media reacted with outrage that the Prime Minister was drawing attention to the sexism experienced by women in public life. Critics attacked Gillard for "playing the gender card" - as though she should ignore this sexual vilification. But to remain silent would condemn others to experience the same treatment, just as silence over domestic violence still does.
Gillard had studiously ignored gender issues during the 2010 federal election, going so far as to "forget" to allocate a Status of Women portfolio immediately afterward. She was much more likely to don a hard hat than to identify as a feminist, despite being instrumental in changes of particular importance to women, such as the replacement of WorkChoices by Fair Work Australia.
What happened between 2010 and 2012? Gillard had been subjected to an unrelenting campaign of vilification by a loose coalition of shock jocks, bloggers and newspaper columnists.
The campaign has been rhetorically violent in nature at times. Talkback radio host Alan Jones suggested Gillard be put in a chaff bag and taken out to sea, presumably to drown. His justification was that she was a "liar", having broken a campaign promise not to introduce a carbon tax.
Television watchers also saw a banner reading "JuLIAR ... Bob Brown's bitch" behind opposition leader Tony Abbott while he was speaking to an anti-carbon tax rally at Parliament House in 2011.
This lack of respect contrasts strongly with the treatment of Denmark's first female Prime Minister, Helle Thorning-Schmidt, who took office in 2011. Thorning-Schmidt also headed a minority government and faced numerous accusations of broken election promises - but not of being a "liar" or someone's "bitch". She explained that the Government had made a mistake in not making sufficiently clear that the election result demanded compromises.
In the past fortnight outrage has again been expressed over the Prime Minister's speech to the launch of the Women for Gillard campaign. The speech was largely a summary of policy gains under Labor governments, including the Rudd and Gillard governments. It covered paid parental leave, the equal pay win by community service workers and the increase of the tax-free threshold to A$18,000 ($21,400), of particular benefit to part-time and low-paid women workers.
What was extracted for media headlines was a clumsy warning about "men in blue ties" retaking centre stage in Australian politics, and a single sentence about abortion again becoming the "political plaything of men who think they know better". And yet, there has been little media attention to the drop in women's political representation across Australia since 2009.
Was it outrageous of Gillard to raise the issue of abortion? Given the halt to overseas aid for family planning during the Howard period, the ministerial veto on importation of RU486, and the federal funding of misleading pregnancy counselling services, this hardly seems an irrelevant concern.
No reasonable person could argue that all the policies of the Gillard government have advanced gender equality. Cuts to public expenditure always have a disproportionate impact on women. The shift of sole parents on to the Newstart Allowance was strongly resisted by elements within the parliamentary ALP.
But regardless of the reasons, the issue of gender equality has once again been put on the political agenda - where it should be, as long as women remain underpaid, under-represented and at risk of violence from their intimate partners.
Marian Sawer is emeritus professor at Australian National University and chief investigator on the project Women and Leadership in a Century of Australian Democracy.


text:
Title: Codrescu collection, 1929-2004
Extent: 0.0
Languages: Romanian
Repository: Rare Book & Manuscript Library, University of Illinois at Urbana-Champaign
Access Restrictions: Open to researchers.
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The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted materials.
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This institution reserves the right to refuse to accept a copying order if, in its judgement, fulfillment of the order would damage materials or involve violation of copyright law.
Processing Information: https://wiki.cites.uiuc.edu/wiki/display/librare/Home
Maria Manoliu-Manea business card with handwritten compliments on it; was located in COD 949.8R662
"Romanii in stiinta su cultura occidentala" (pg.87).


text:
Originally Posted by Andrey Limonchenko
I am glad you agree with them that much. This might be helpful to you: http://www.epa.gov/jobs/openings.html
I didn't say I agreed with them. I was just pointing out inaccurate information in your post.
Anyway it would be a long commute from Ireland and it's hard to work properly with jetlag.
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That's pretty good. I am bout tired of the love bugs myself. They swarm my grill when I am cooking.
This is a discussion on If you grew up in South Florida... within the Off Topic & Humor Discussion forums, part of the The Back Porch category; Socks are only for bowling. You never use an umbrella because you know the rain will be over in five minutes. A good parking place ...
Socks are only for bowling.
You never use an umbrella because you know the rain will be over in five minutes.
A good parking place has nothing to do with distance from the store, but everything to do with shade.
Your winter coat is made of denim.
You can tell the difference between fire ant bites and mosquito bites.
You are younger than thirty but some of your friends are over 65.
Anything under 70 is chilly.
You pass on the right and honk at the elderly, but pull over for a funeral.
You have driven through Yeehaw Junction.
You could swim before you could read.
You have to drive North to get to the South.
You know that no other grocery store can compare to Publix.
You got out of school early on Halloween to trick-or-treat before it got dark.
You know that anything under a Category 3 just isn't worth waking up for.
You dread love bug season.
You are on a first name basis with the Hurricane list. They aren't Hurricane Charlie, Hurricane Frances....but Charlie , Frances , Ivan and Jeanne.
You know what a snowbird is and when they will leave.
You think a six foot alligator is actually pretty average.
You were twelve before you ever saw snow, or you still haven't.
"Down South" means Key West .
You think New York drivers licenses should only be valid in New York .
Flip-flops are everyday wear.
Shoes are for business meetings and church.
Sweet Tea can be served at any meal.
An alligator once walked through your neighborhood.
You smirk when a game show's Grand Prize is a trip or cruise to Florida .
You measure distance in minutes.
You have a drawer full of bathing suits and one sweatshirt.
A mountain is any hill 100 feet above sea level.
You think everyone from a bigger city has a northern accent.
You know the four seasons really are.....Hurricane Season, Love Bug Season, Tourist Season and Summer.
It's not soda, cola or pop. It's Coke regardless of brand or flavor, "What kinda coke you want?"
Anything under 95 is just warm.
You have hosted a hurricane party.
You go to a theme park for an afternoon, and know when to get on the best rides ( Space Mountain during the Electric Light Parade)!
You understand why it's better to have a friend with a boat, than to have a boat yourself.
You were 5 before you realized they made houses without pools.
You were 25 when you first met someone who couldn't swim.
You've worn shorts and used the A/C on Christmas.
You recognize Miami/Dade as " Northern Cuba ."
You understand the futility of exterminating cockroaches.
You have to make the shot when fire is smoking, people are screaming, dogs are barking, kids are crying and sirens are coming.
Randy Cain.
Ego will kill you. Leave it at home.
Signed: Me!
That's pretty good. I am bout tired of the love bugs myself. They swarm my grill when I am cooking.
Glock 27
My wife, who grew up in Homestead, related to EVERY one of 'em........she didn't even laugh.
Those are great Miggy
Drove through it? Heck, I've stopped in Yehaw Junction!
When my daughter was in kindergarten, they were learning about the 4 seasons and she was struggling. I couldn't understand why until she explained......
"But Daddy, they say Summer is when it's hot.....but it's always hot. They say Fall is when the leaves turn colors, and the leaves never change color here. They say that Winter is when it gets cold and snows, but it's never cold and I've never seen snow........and they say that in the Spring, the flowers bloom, but Mommy's flowers are always pretty.
Poor kid........
I think we must explain what Yehaw Junction is to those lost in the joke.
Yehaw Junction is that empty crossroads town you see in the movies. Other than a motel and shacks offering discounted tickets for Florida attractions, there is literally nothing but maybe a traffic light and lots of dust.... if it is in season. There is actually more construction in all the road signs you see advertising the place along the highways than in the town itself. I driven at least twice by it, both times at night and both times I missed it 'cause I was not paying attention. Here is the satellite picture of it.
Map of Latitude: 27° 42 Min. 0 Sec. Longitude: -80° 54 Min. 16 Sec., by MapQuest
You have to make the shot when fire is smoking, people are screaming, dogs are barking, kids are crying and sirens are coming.
Randy Cain.
Ego will kill you. Leave it at home.
Signed: Me!
Lifetime Floridian here, can relate to EVERY one of those...
I didn't grow up in florida, but I was stationed there (and VERY close to it in GA) and thought this should be added.
You know that there is no sense in washing your car...if you plan on driving it this week. (BUGS)
They who give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety. Benjamin Franklin
Previously known as "cjm5874"


text:
Thursday, December 9, 2010
Quiet whispers...
14 comments:
- a cup and a cake said...
Thats a gorgeous photo and a beautiful chest of drawers... that style always makes me which I had a beach house to put pretty things like that in :) V xx
- December 9, 2010 at 9:40 AM
- GB said...
Saw this yesterday and thought of you immediately!
- December 9, 2010 at 10:13 AM
- Sound Horn Please said...
I currently have this thing for drawers with colored knobs and the ones in anthropologie make me droool! I'm so glad you stopped by, I got to discover you :) Following!
Also, feel the same way about decor8!
- December 9, 2010 at 3:59 PM
- a Broad said...
Oh sweetie if only I had a day of quiet.
I love this ! I have to go look a decor8 some more !
- December 9, 2010 at 4:32 PM
- Emilies interiør said...
What a beautiful picture! And thank you for your nice comment, that means so much!
Have a lovely weekend:)
- December 9, 2010 at 11:13 PM
- Krystal said...
ohhh that is so pretty. I like the vases.
- December 10, 2010 at 2:58 AM
- time worn interiors said...
The chest is wonderful, love the paint color!
- December 10, 2010 at 4:05 AM
- design traveller said...
simply charming... If I could have a cottage by the lake, that would be my style :)
- December 10, 2010 at 6:43 AM
- PoshAndBroke said...
I love the way that you write - it's almost soothing... So happy I found your site. 'Bookmark' all the way.
- December 10, 2010 at 7:37 AM
- Jenn said...
LOVE Knack Studios! Barb does amazing work. She is hosting a weekly column at Design Sponge ... have you seen it? Great pointers for creating fun furniture.
- December 11, 2010 at 3:59 PM
- knack said...
thank you so much or the knack love! I really appreciate you showcasing miss aziel on your beautiful blog, and for visiting my blog too!
merry christmas!
- December 16, 2010 at 12:16 PM
- Olivia.Dee said...
that chest of drawers is divine.
- December 19, 2010 at 11:33 PM
- Geisslein said...
Oh I love Knack and Barb and her work! Always a great inspiration for me! I like your blog! happy new year for you! greetings from germany, geisslein
- January 5, 2011 at 3:49 AM
- Liv said...
This is such a beautiful dresser. It's the most beautiful piece of furniture I have ever seen. I know because whenever I look at other furniture, online or in my own house, I can't help but think that it's not as good as this one. I found this picture on Pinterest, pinned it right away, and I keep coming back to it. Your blog is amazing, and this is the most amazing thing I've found on it. Thanks for posting it so many years ago! It's fantastic. Where on Earth did you find it? Is it just a picture or really yours? I can't help but ask. It's beautiful.
- July 17, 2013 at 8:03 PM


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With a revamp of fishing rules in Rotorua, anglers will have more chance of catching a fish this summer.
The rules' rewrite has opened up more lake shoreline fishing, which means anglers don't need a boat _ just some spin fishing gear.
Spin fishing or spinning is an easy method using light-weight gear where a spinning lure, which imitates a bait fish, is cast out and retrieved.
Fish & Game's revamp of the rules opens up the whole of Lake Tarawera's shoreline for spinning between October 1 and the end of March every year and some locations after April 1.
Eastern Region Fish & Game officer Matt Osborne said the changes meant more opportunities for holidaymakers this summer.
One of the key aims was to make the rules easier for everyone to understand.
The regulations for shoreline fishing on Lakes Tarawera, Rotoiti and Okataina were identified as particularly complicated. Now, instead of some areas being fly fishing only at this time of year, the whole shoreline is open to spinning and fly fishing.
"Rock on up at any spot along the shore on these lakes and you're safe in the knowledge it's legal to fish there,'' Mr Osborne said.
The changes mean easy spinning methods can be used at some popular holiday spots like The Landing on Lake Tarawera.
Other areas where spinning was previously banned include The Orchard, around the point from The Landing, and the Waitangi Stream mouth.
The new rules bring Tarawera into line with Rotoiti and Okataina.
However, exceptions do remain, such as on Lake Rotoiti where spinning is not permitted within 300m of the Ohau Channel delta's landmark pole.
Mr Osborne said spinning was the perfect choice for holiday makers with families. "It's easy for children to pick up _ they learn quickly and if you're the father, uncle or granddad doing the teaching _ it's also a fast method to teach.
"Children can learn to spin pretty competently in about 10 minutes compared with the 10 hours that might be needed to teach fly fishing skills.''
Meanwhile, Mr Osborne said even though rules had simplified it didn't mean other rules and regulations had been relaxed.
For more information on the rules see the North Island sports fishing regulations booklet or visit www.fishandgame.org.nz
Fish & Game is also reminding anglers of the ``check, clean, dry'' message which applies to both boats and trailers and personal gear such as waders and fishing equipment.
"Rotorua's lakes and streams are free from most pest fish and some aquatic weeds and we need anglers to help us keep it that way.''


text:
Rigorous and precise, creative and curious, experimental and leading edge—each quality contributes to being the best. We embed those qualities in our degrees, cultivate them in our students, and relish them in our facility. You can see them in our national rankings and the caliber of our students and our faculty.
Copyright © 2017 Ball State University 2000 W. University Ave. Muncie, IN 47306
800-382-8540 and 765-289-1241


text:
Very cute quilt.
Welcome to the Quilting Board!
Terrific quilt, great job and thank you for sharing
Have a Blessed day
Great quilt and I love the picture on the label idea.
nicely done, i like the pic on the label idea. i was doing that, but had forgotten. thanks for the reminder
Nancy in western NY
before you speak THINK
T is it True? H is it Helpful? I is it Inspiring? N is it Necessary? K is it Kind?
good way to work with a panel!
enjoyed reading this site..love to sew. quilted for 47 yrs and still love it & learning new ideas
The quilt is so cute and I like how you did your pic on the label. This is a good idea!
God, Wonderful Family, Great Health, Awesome Friends, Quilting & Chocolates - - What more could a girl be blessed with!!
I really like the idea of your picture being on the label!
You don't stop laughing because you grow old. You grow old because you stop laughing.
A smile is something you can't give away; it always comes back to you.
That is very nice, great job.
Malega K.


text:
All posts by Elmer Kelton
Twin Wells
The final chapter of "Twin Wells," by Elmer Kelton.
True Grit
Once upon a time, before the pundits and the politicians hijacked it for their nefarious ends, "cowboy" wasn't a dirty word. The lifestyle and worldview it suggested was seen as completely in line with the very finest Texas values: hard work, independence, honesty, decency, valor. For the sake of today's generation of ranch hands and cattlemen, it's high time we steal it back.
Twin Wells
Chapter One: "A Stranger Comes to Town"
Bone Dry
From water rationing to stricken crops, the current drought may be as devastating as the one in the early fifties—the time it never rained.
Having a Cow
Beyond Beef blames cattle for the decline of civilization—not to mention famine, pestilence, destruction, and death.
My Favorite Place
What do the city of Lubbock, a defunct restaurant, and a submerged neighborhood have in common? They're all places in somebody's heart.
Earth, Rain, Wind, Fire
A wet year followed by a dry one made for one hellacious brush with disaster in the ranchlands of West Texas.
Habits of the Heart
Time-honored Texas rituals.
The Time It Always Rained
The wettest spell in memory has given the people who live in West Texas an unfamiliar topic of conversation.
When the Well Runs Dry
In parts of Texas drought is a steady boarder who may stray but always comes home for supper.


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Wednesday night's dinner at Loggerheads, the rococo mud brick house Len Evans built in the Hunter Valley, was typical of Evans the host. Knowing his wife would be in hospital that day I tried to persuade him to cancel it but anyone who has ever met him will know that I was wasting my breath. That morning at least one other dinner guest,…
Written by 18 Aug 2006
Len's Last Supper
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Hi, IGN bloggers who have drunkenly stumbled upon my post in the hopes of clicking upon someone popular's post. Please, don't be alarmed by the monkey at the top of the page, he means you no harm as he believes he is a human and is poaching monkeys.
I think it's time to bring up something I believe has been brought up before; whether it's A historic or An historic. An historic seems odd to me, because the 'h' negates the need for an 'n'. However, it does bear some similarities to other 'an h____' words, such as 'an hour.' I believe that it should be a historic, because the 'h' and 'n' don't mix. They're like an old married couple; they've been together so long, people start to think they never should have gotten together because they cause so much trouble. My theory is that the 'n' was HAMMER drunk, and the 'h' was in the wrong place in the wrong time.
And one last time, yes, that is a monkey holding a glock.


text:
By: Mehroz Baig Read more »
Timothy Schoechle, Ph.D., Author, "Getting Smarter About the Smart Grid," published by the National Institute for Science, Law and Public Policy, Washington, D.C. Read more »
Patricia Schultz, Travel Journalist; Author, 1,000 Places to See Before You Die Read more »
Mike Korchinsky, Project Developer, REDD+ (Reducing Emissions from Deforestation and Degradation); Founder and CEO, Wildlife Works
TJ DiCaprio, Senior Director, Environmental Sustainability, Microsoft Corporation
Sissel Waage, Director of Biodiversity & Ecosystem Services, Business for Social Responsibility Read more »
Fran Pavley, Senator, California State Senate
Annie Notthoff, California Advocacy Director, NRDC
Paul Deiro, Energy Lobbyist, KP Public Affairs
Governor Brown's signature on a bill regulating hydraulic fracturing upset just about everyone. Industry said it imposed harsh requirements on them and would hurt the economy. Environmentalists said last-minute changes appeased industry and put the state's water and air quality at risk. Read more »
Fred Turner, Associate Professor of Communication and Director of the Program in Science, Technology and Society, Stanford University; Author, The Democratic Surround: Multimedia and American Liberalism from World War II to the Psychedelic Sixties Read more »