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Sep 6, 2013|
John Farrell talked to Joe Castiglione before the second game of the New York series. John told Joe that the Sox use the running game when it's advantageous.
Transcript - Not for consumer use. Robot overlords only. Will not be accurate.
When Johnson a great team win last night but a most unusual script this Italy east. Yeah was Joseph when he when -- think that they're going into the bottom of the seventh inning were up five. Jake. While not. Maybe dominant or overpowering last I -- -- still Pittsburgh a ball game where the bottom part of the order. Felt like even with the -- for -- sort of thrown -- chances you know get recorded Roberts who and then we turn around the top of the order we had Horton waiting and unfortunately. Things didn't work out that way as we went through three pitches that inning they scored six. But down nor the last strike human aptly it's a big base hit and the acquired Quinton Barry. Who we brought in for that specific purpose. Achieved everything we -- of hope today and as we saw the two stole bases in the ninth and -- proved pivotal pivotal and that and that outcome. I was -- Dave Roberts all over again in the course Els with a steal this isn't the mentioned Red Sox themes that I've had -- maybe some of your rep. Best competitors in the yet American League don't have like the tigers. Well I think we we value not only the use the stolen base but but giving us other opportunities and a little bit more diverse on an offensive side of the game so when we're going up against certain pitchers and and in key spots late in the game if we can advance ninety feet either through straight steal or being a little more aggressive on the base that's. Will look to do that to put pressure on the defense and last night with the errant throw viral mind sets things up for for Stephen -- to have to drive you know the -- -- It is our allies that. Give up the lead it looked like it has some great pitches and then some that were well below his standards. Well the frustrating thing about that seventh -- -- is that. I think for the basics that we allowed in the seventh came with a either an -- -- 12 count and that just speaks to the finishing pitch or maybe rushing into things to. To try to finish her off and the -- it was elusive last effort is our particularly. Who was a split finger you know it goes he goes to throw the split finger to overbay -- stays -- metal plate for the two run single. But the at bat before that two -- -- Rodriguez who throws a very good one to strike him out and and right now I think at times he's trying to overthrow that pitch -- throws right through. The depth through the sink to the split finger and -- his grip is getting too tight. And not on that relaxation to allow the bottoming out actions take place. Last night to give up a hit to Soriano with three infielders on the left side you'll be shifted that Soriano came up later drew a walk with Breslow pitching. And day. Did did not over -- that what is the thinking behind that. Well joy against it all the all the information that we go through with -- every hitter that we're gonna face against right handers. Soriano and only hit three balls to the right side of the infield all season long whether that's -- with New York or with the cubs. But against left handers who sprayed the ball around to field a little bit more because left handers will. Will pitch him away a little more regularly. So that's the information news that's what the positioning calls for an unfortunately just -- -- is -- on its. A nice soft ground ball right through the the straight up position of of the normal defense but. We stick with our process we we believe -- it. The the concerning thing would be is if we change on the fly so much of -- players will be -- follow us and the rationale behind why we use the ship so. Unfortunately he hit against that -- and work out our favorite last night. Koji 120 pitches probably double as Norman LaMont but again that perfect and use them tonight. Well we'll check with him as he goes through -- throwing program here today but the twelve pitch at bat overbay it was a it was a tough about four overbay lined him I believe a double off a -- last time that they were up in Boston. And and we played them back home so. Over -- got a swing that he'll stay in the middle of field and he'll be able to guard against that changes speeds a little more regularly than maybe some other hitters he faces. But still a 12310. Clean safe and a and a very good. Hard fought win last night. Clay Buchholz and his final rehab start last night Hannity come through it and what the plans. Physically he came through fine 71 pitches thrown in three and two thirds you know if there was anything you'd like to see more it might have been one more up and down maybe giving into that fifth inning which would have built upon his four up and down. Sessions or innings last time out so physically he's fine. He's back in Boston taking care Lindsay yeah and the birth of their new child just a couple of days he'll he'll rejoin us here tomorrow in New York. Throws open on Sunday and provided he comes with a fine we've been hesitant to just rush into an announcement of any kind of claim is making sure we take every step along the way and and -- ally in -- and others rule talks are on how we look to insert him back. On the activist here force. And did Ellsbury is not in the lineup today that it would issue. Yeah you know he he felt up -- office for the last homestand we have to take mobile game that night last night on that final stolen base when he slid into second -- -- real aggravated it so. He's office feet today getting full day of treatment so were hopeful we'll be back -- -- more. Our -- as manages question. Matchup tonight did do Barack and panic that no they have different. Stuff but they have some similarities to don't think. Well they do I think you can just look at the delivery there's some similarities to it there's a four pitch mix that are similar the velocity might be a little bit different the action might be a little bit different. Certainly the career path and the success that any pettis had is is just outstanding and he's controllable very good. And he -- you know he he pitched a very good game against this back in Boston where he stayed out of a little plate his stuff was -- So that these two guys going up against one another you know you see some similarities but it'll be important for. Once again for for to brought to stay in the bottom of the strike Sony gets is right -- hitters like tonight yes thanks Joseph appreciate it. Our question with a manager was brought to you by Mercedes bans the although Mercedes-Benz CLA is arriving at your local Mercedes-Benz dealers this month. The CO -- superior technology engineering and safety you've come to expect from Mercedes-Benz at a price you'd never -- comic. Is it MB usaid dot com slash CLA.


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If you're a liberal Jew, there are denominations for you. If you're a liberal Christian, you've got them, too. Liberal Muslim? Not so much.HuffPo has a piece about how this might be changing: … [Read more...]
Reform Islam?
What's Sauce For The Goose…
A few weeks back an organization called the Texas Association of Private and Parochial Schools (Tapps) told Beren Academy, an Orthodox Jewish school, that its team could either play its state semi-final game on Shabbat or it could forfeit.Despite pleas from the mayor of Houston and NBA coach Jeff Van Gundy - coupled with a willingness by other teams to re-schedule - Tapps stood firm. Only under threat of a lawsuit did it rescind the decision. … [Read more...]
Sharia Hysteria And Unintended Consequences
In their continuing effort to make false distinctions among fundamentalist Islam, Christianity and Judaism, lawmakers here in Florida have crafted a law intended to block the rapid (imaginary) spread of Sharia law in America. Unfortunately for them, it will also affect the application of Jewish halakha in certain cases (from the Forward): … [Read more...]
Some Thoughts About Islam (And The Israeli-Arab Conflict)
These days, it seems that most critiques of the Islamic world come from American and European wingnuts. Pamela Geller literally makes my skin crawl with her imbecilic bombast about a Sharia takeover of the U.S. and the dangers of a mosque near Ground Zero. David Horowitz hypocritically names his anti-Islamic organization "The Freedom Center" while he endorses a U.S. constitutional amendment to ban same-sex marriage. And don't get me started on the fundamentalist Christian right and their ongoi … [Read more...]
And They're Off! The Race To Bait American Muslims
The only thing more pathetic than listening to the Republican candidates try to top each other on who's more Christian is listening to them talk about Islam.I didn't watch the debate the other night because I'd rather drink a gallon of Drano than spend two seconds with these people on my television set. I did hear some of the lowlights. Take for example Godfather's Pizza CEO Herman Cain (via CNN's site): … [Read more...]
Rockets In Southern Israel. Again.
I am watching the Channel 2 news from Israel. Rockets are dropping in southern Israel again, fired by terrorists in Gaza. I supported Operation Cast Lead and would do so again. I don't make false proportional comparisons between a nation defending her citizens and a bunch of radical Muslim terrorists hiding behind children. If those children die, their blood is on the hands of the terrorists. … [Read more...]
Twin Religious Fanatics Of Different Mothers
Lately I have been spending a lot of time thinking about the relationship between conservative Christians and their Islamic counterparts. These days (especially in the decade since 9/11) conservative Christians have been involved in a non-stop assault on Islam.It's manifested itself in the opposition to building mosques (not just in Lower Manhattan) and banning Sharia law. Imaginative Christians have even managed to create the impression that there is some kind of destructive cabal con … [Read more...]
Post-Theistic Religion©
Another non-theistic reinterpretation of religion has been published by a fellow named Bo Bennett. According to various web sources, he's a young self-made millionaire. His book is The Concept: Introduction to Christian Nontheism. From the publisher: … [Read more...]
Church Of England Declares War On New Atheism
Archbishop of Canterbury Rowan Williams has given his backing to a draft report calling upon clergy to take on the new atheists:Clergy are to be urged to be more vocal in countering the arguments put forward by a more hard-line group of atheists such as Richard Dawkins and Christopher Hitchens, who have campaigned for a less tolerant attitude towards religion.What scares them so much about the new, more vocal arguments of the new atheists? They fear loss of power. Yes, even the Church of E … [Read more...]
Netanyahu Steps In It
Just a day after I praised the Israeli response, Netanyahu undoes any good he might have done:"Our real fear is that you have a situation that may develop of very quick changes taking place" that are devoid of modern democracy and "where you see the form of fundamentalist Islam," Netanyahu said at a news conference to mark a visit by German Chancellor Angela Merkel.On top of this, he's not-so-quietly lobbying EU and U.S. leaders to show more support for Mubarak. … [Read more...]

subset: commoncrawl


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Best Places to Cool Off in Evansville This Summer – Our Top Five
Let's face it, summer is officially here and what that means is crazy Indiana weather phenomena and soul-crushing heat. I'm sure there are plenty of people out there who love getting sunburnt to a crisp and sweating in places that makes it look you had a accident (Swamp Butt is the term I would use). Well, for those that want to keep cool there are a number of places in Evansville to help cool you down during the summertime heat.


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You know … as kinda gross as Cristiano Ronaldo's overtanning makes him look sometimes, there are other times that A.) he don't look all that gross any more and B.) the boy is able to still get some action. Here are a couple pics of the crispy-fried soccer phenom enjoying the attention from a female admirer and a nice view of his wet bum as he got out of the pool:
Yeah … I think he looks much better when he's in the sun (and wet) rather than inside under normal lighting conditions (and not wet) cuz his suntan works better in the daylight. OY! I still fear for the lad's possible run-in with skin cancer down the line but … he's lookin' much nicer this time around.


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Elevate Uganda was started in September of 2013 by a middle school youth group from Community Bible Church in San Antonio, TX. When the pastor challenged the congregation to make a difference, we went with our heart and chose to make a difference in Uganda, Africa.
Our goal is to raise $100,000 to build schools in villages where education is needed. We have partnered with Villages of Hope Africa, who has already done amazing things in Gulu Uganda, to help us with our project.
By 2015 we had raised enough money to build our first school so VOHA found a village named Olee that needed a school. The school pictured to the left (above "Our Story" ) is the completed school. We were blessed to be able to have a small group of 10 go to Uganda in the summer of 2015 for the ground breaking of this school. Please help us spread the word so we can continue to make education a reality in even more villages.
In 2013 our youth group was challenged to "Make a Difference." Click below to find out why we chose to make a difference on the other side of the world.
Villages of Hope Africa is doing amazing things in Uganda by building wells, spreading God's word, and restoring villages. We are happy to partner with them to help Educate the children of Uganda.
**This is not an official website of Community Bible Church
From the beginning of this project, our goal has been to raise $100,000 by asking 100,000 people to donate $1 each. Help us achieve this goal by praying for us, spreading the word, and donating to our project.


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Shasta Lake dive death report spells out cause
REDDING, Calif. - A detailed report regarding the tragic death of a volunteer diver working with a team on a recovery on Shasta Lake in September 2013 shows multiple lapses.
KRCR was able to attain a copy of the lengthy investigation after filing a Public Record Act request with Shasta County.
Volunteer diver Ken Smith died September 8, 2013, while trying to recover a robotic vehicle being used in a search for a person who drowned in Shasta Lake.
A Shasta County deputy was also seriously hurt trying to save Smith.
Now a nearly 200-page report from the L.A. County Sheriff's department reveals exactly what went wrong.
Included are interviews with San Francisco Police Department divers who were also on hand, Shasta County sheriff's deputies at the scene as well as Smith's wife, Cheryl.
Among the pages, a diagram shows how the robotic vehicle became trapped in a large oak tree 143 feet below the water's surface.
And among the findings, the report claims Smith was not experienced enough for the deep dive. Smith had been referred to the sheriff's office by a friend who was requested to help in the search but was out of town.
The report also said he wasn't properly supported by personnel above and was without communication with a safety diver because of poor visibility.
It also said Smith didn't have enough air to make the dive and the air he was using wasn't adequate to support breathing at that depth. It says nitrogen levels in his air were too high and worked as a narcotic at the depth he was diving.
At the level Smith was diving he used his air six times faster than he would at the top.
What's more, Smith's regulator wasn't serviced properly and needed tuning before undertaking such a deep dive.
Smith was found at the bottom of the lake, some 173 feet below, weighed down by his gear and other apparatus meant to allow him to sink into the deep water. The report says the fact that he didn't released weights attached to him is an indication he never even made an attempt at an emergency ascent to the surface.
Smith's wife, Cheryl, filed a claim against Shasta County.
That claim was rejected, setting the stage for a court battle.
Shasta County Sheriff Tom Bosenko declined to comment on the report, citing legal reasons.


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As they say, YMMV, or Your Mileage May Vary. Verizon coverage has been great for me, and when I do have a problem with something, their customer service has been easy to get to and have been able to help. Plus they follow up to make sure that the problem that was fixed has stayed fixed.
On the other hand, VZW isn't cheap. For my family plan with three smartphones I pay about $230 a month. T-Mobile offers an equivalent plan for about $100 a month but I don't know how good their call quality really is. Everybody has a story, no matter which carrier they're on. Anybody care to chime in about T-Mobile call quality in Pleasanton and the Bay Area in general?


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Kid Rock Club Tour Raises $375,000 for Local Charities
Country-rock rebel Kid Rock has raised more than $375,000 for various causes, with a few concerts left for his 12-date club tour in support of local charities. The goodwill outing was inspired by 'Care,' the fifth single from Kid's most recent album, 'Born Free.'
"The song says 'the least that I can do is care' — and I want to put my money where my mouth is," Kid tells Billboard. "Everyone knows that Detroit is hurting. But I want to show that even though we don't have a lot on our own plate, it doesn't mean the people of my hometown don't have compassion to share with others all over the country. At the end of the day we're all Detroit, we're one country, one family."
Kid Rock is scheduled to appear on 'CNN Heroes: An All-Star Tribute,' performing a special version of 'Care' for the live broadcast. Hosted by Anderson Cooper, the star-studded telecast will spotlight the accomplishments of the Top 10 CNN Heroes, with each humanitarian receiving $50,000 in recognition of their achievements. The show will announce the winner of the public-voted CNN Hero of the Year, which is accompanied by a grand prize of $250,000. Click here to vote.
Tune in Dec. 11 at 8:00 PM ET on CNN to catch Kid Rock's live performance.
Kid Rock Charity Tour Dates:
Nov. 29 – Midland Theatre – Kansas City, Mo
Dec. 1 – Fillmore Auditorium – Denver, Colo.
Dec. 3 – The Great Saltair – Magna, Utah
Dec. 4 – Knitting Factory – Boise, Idaho


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Thursday, August 17, 2006
Quest Receives Nasdaq Notice, Faces Delisting
Aliso Viejo-based Quest Software said today that it has received a Nasdaq Staff Determination letter, indicating that the firm is not in compliance with continued listing requirements, and is subject to delisting. The firm received the notice because it did not file its 10-Q for the quarter on time. Quest had delayed the filing of its 10-Q due to an ongoing investigation into the firm's stock options grant practices. The firm said in a statement that it will request a hearing before a Nasdaq Listing Qualifications Panel to review the Staff Determination. Quest currently has a special committee looking into its grant practices, and has already said that it will restate its financials between 2000 and 2005. The firm, which is listed on the Nasdaq as QSFT, is among one of the many dozen high tech companies that has been caught up in an industry-wide, stock options backdating scandal.


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Digital Radio Mondiale (DRM)
Nautel NX50 MW running DRM live
More videos »
Nautel's NX Series & the World's Largest Digital Radio Deployment to Date »
Nautel VS1 puts DRM+ On-Air in India »
International DRM Tutorial Webinar »
DRM+ Completes the DRM Standard »
DRM Introduction and Implementation Guide
Product newsMore Product News »
Digital Radio Mondiale (DRM) is the universal, openly standardized digital broadcasting system for all broadcasting frequencies up to 174 MHz, including LW, MW, SW, band I and II (FM band). It has been endorsed by the ITU, IEC and ETSI. DRM's near-FM audio quality is excellent and the improvement upon analogue AM is immediately noticeable while DRM+ sound quality exceeds that of analog FM broadcasting, providing listeners with near CD quality sound. DRM can be used for a range of audio content, including multilingual speech music as well as offering the ability to integrate data and text. This additional content can be displayed on DRM receivers to enhance the listening experience.
Nautel DRM Solutions
Nautel offers the industry's broadest offering of solid-state DRM models ranging from 1 kW to 2000 kW.
- AM and Medium Wave Transmitters for DRM30 Transmission
What are the Benefits of DRM?
DRM provides the exceptional sound quality and ease-of-use that listeners have come to expect from digital radio as well as a host of additional features:
- Surround Sound
- Journaline text information
- Slideshow
- EPG (Electronic Program Guide)
- Data Serivces
- Diveemo – Motion Video
For broadcasters, especially those broadcasting internationally, DRM means expanded coverage and the ability to provide millions of listeners with improved sound quality and a host of additional features not available with analog broadcasting. With its exceptional reach, DRM can also help broadcasters control their capital expenditure by eliminating the need for a network of transmitters or repeater stations. DRM is an ideal solution for broadcasters aiming for a national audience. Transmission costs for DRM broadcasts are no higher than those of analog Short and Medium wave broadcasts. DRM is also ideal for regional broadcasters who are trying to reach niche markets. The additional features offered by DRM and DRM+ help broadcasters target individual cities or smaller markets and develop additional revenue streams.
The World's Largest Digital Radio Deployment To DateAll India Radio (AIR) is converting all its short wave and medium wave transmitters in India to DRM digital transmission.
All the MW transmitters are supplied by Nautel (NX Series), are configured for DRM30 transmission, and are being used in 27 locations throughout India.
Learn more about All India Radio's High Power DRM-MW-AM deployment >
To learn more about how broadcasters can benefit from DRM and DRM+ technology, go to Digital Radio Mondiale.


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Target's pharmacy division got a big boost early this month when the Industrial Designers Society of America named its ClearRx bottle for prescription drugs the Design of the Decade. The award — coupled with another J.D. Power customer satisfaction award earlier this year — are affirmation that the 1,752-store big-box giant is on the right track as it renews its niche in health and wellness.
Target called it "pharmacy rethought from the bottle up" when it was introduced more than five years ago. Now, the company's breakthrough ClearRx packaging innovation for prescription drugs has been named Design of the Decade by the Industrial Designers Society of America.


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Related links
Brazilian Journal of Medical and Biological Research
On-line version ISSN 1414-431X
Braz J Med Biol Res vol.41 no.3 Ribeirão Preto Mar. 2008 Epub Dec 20, 2007
Braz J Med Biol Res, March 2008, Volume 41(3) 229-234
The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications
C.B. Leitão1, G.B. Nabinger1, A.L. Krahe2, P.B. Bolson1, F. Gerchman1, R. Friedman1, J.L. Gross1 and L.H. Canani1
1Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
2Serviço de Medicina Interna, Universidade Luterana do Brasil, Porto Alegre, RS, Brasil
Material and Methods
Correspondence and Footnotes
The aim of the present study was to analyze the frequency of K121Q polymorphism in the ENPP1 gene of Brazilian subjects according to ethnic origin and to determine its possible association with diabetes mellitus (DM) and/or diabetic complications. A cross-sectional study was conducted on 1027 type 2 DM patients and 240 anonymous blood donors (BD). Ethnicity was classified based on self-report of European and African descent. The Q allele frequency was increased in African descendant type 2 DM patients (KK = 25.9%, KQ = 48.2%, and QQ = 25.9%) and BD (KK = 22.0%, KQ = 53.8%, and QQ = 24.2%) compared to European descendant type 2 DM patients (KK = 62.7%, KQ = 33.3%, and QQ = 4.1%) and BD (KK = 61.0%, KQ = 35.6%, and QQ = 3.4%). However, there was no difference in genotype distribution or Q allele frequency between diabetic and non-diabetic subjects (European descendants: DM = 0.21 vs BD = 0.21, P = 0.966, and African descendants: DM = 0.50 vs BD = 0.51, P = 0.899). In addition, there were no differences in clinical, laboratory or insulin resistance indices among the three genotypes. The prevalence of DM complications was also similar. In conclusion, K121Q polymorphism is more common among Afro-Brazilian descendants regardless of glycemic status or insulin sensitivity indices. Likewise, insulin sensitivity and DM chronic complications appear not to be related to the polymorphism in this sample.
Key words: ENPP1 polymorphism; Ethnicity; Type 2 diabetes mellitus
The ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars. The ENPP family is involved in a variety of processes that range from bone mineralization to insulin action signaling (1).
Several polymorphisms are located in the ENPP1 gene (2,3), the one most frequently analyzed being located in exon 4 and causing an amino acid change (K121Q). The variant allele (risk allele Q) is associated with a stronger interaction of the protein with the insulin receptor compared to the wild allele (allele K), resulting in a reduction of insulin receptor autophosphorylation (4). Due to its effect on insulin signaling, ENPP1 is a candidate gene for insulin resistance and/or development of diabetes mellitus (DM).
The clinical manifestation of this polymorphism has not been well established. Even among Caucasian subjects, the effect of the presence of Q allele varies. Sicilian, Swedish and Finnish carriers of the Q allele have lower insulin sensitivity compared to noncarriers, but this is not the case for Danes or Spaniards (4-8). Other phenotypes possibly associated with this polymorphism may include accelerated atherosclerosis (9), increased proportion of individuals with hypertension (10) or obesity (3) and increased predisposition to diabetic nephropathy (11).
In addition, the frequency of the Q allele seems to be highly dependent on the ethnic group. Dominican Republic subjects have a higher frequency of the Q allele (>0.50) than Caucasian subjects in other countries (~0.15) (12). North American children of African ancestry have an increased prevalence of the Q allele compared to North American children of European ancestry (13). Similar findings were reported recently for African-American adults and adults of Hispanic descent (14). The increased frequency of the Q allele in these ethnic groups might explain their higher risk of developing DM (15) and their higher insulin resistance compared to individuals of European descendent (16). This is also true for other American ethnic minorities (16). However, the distribution of this allele and the possible association of K121Q polymorphism with type 2 DM and its chronic complications in other populations are largely unknown.
Therefore, the aim of this study was to analyze the frequency of the K121Q allele in Brazilian subjects of different ethnic origins, and the possible association of the Q allele with DM and chronic diabetic complications.
A total of 1129 patients with type 2 DM (diagnosis of DM after the age of 35 years and without insulin use during the first 5 years after diagnosis) were identified from a multicentric project aimed at studying risk factors for long-term diabetic complications, which started recruiting patients in the southern Brazilian State of Rio Grande do Sul in 2002. Ethnicity was classified as self-reported skin color and recorded as European descent, African descent, mixed, or "other". Those reporting "other" ethnic origin (N = 5) as well as those reporting mixed origin (N = 97) were excluded. Therefore, 1027 patients were recruited from the outpatient endocrine clinics of the 4 participating hospitals (Grupo Hospitalar Nossa Senhora da Conceição, Hospital São Vicente de Paula, Hospital Universitário de Rio Grande, and Hospital de Clínicas de Porto Alegre). According to the official Brazilian Census of 2000, the ethnic distribution of the adult population of the South Region is 84.5% of European descent, 3.8% of African descent, and 10.4% of mixed origin (17). The European immigration to the State of Rio Grande do Sul was mainly from Portugal, Spain, Italy, and Germany. The subjects reporting African origins descend from people forcibly brought to Brazil between the 17th and 18th centuries, mainly from Angola and Mozambique.
DNA samples from 240 anonymous blood donors (BD) (European descendants N = 149, African descendants N = 91) were also examined for the K121Q polymorphism. The information available for these subjects consisted of age and sex. None of them reported having DM.
The diabetic patients underwent a standardized evaluation consisting of a questionnaire, physical examination, and laboratory tests. Weight (without shoes, light outdoor clothing) and height were measured, and body mass index (BMI) was calculated. Waist circumference was measured at the narrowest point as viewed from the front. Hypertension was defined as blood pressure ³140/90 mmHg or current use of antihypertensive medication. An ophthalmologist performed direct fundoscopy, and diabetic retinopathy was classified as absent, nonproliferative, or proliferative. Ischemic heart disease (IHD) was diagnosed as previously described (18). Briefly, IHD was established in the presence of angina or possible infarct according to the World Health Organization Cardiovascular Questionnaire and/or the presence of resting electrocardiogram abnormalities [Minnesota Codes Q and QS patterns (1.1-2, 1.3); S-T junction (J), and segment depression (4.1-4); T wave items (5.1-3), complete left bundle block (7.1)], and/or the presence of perfusion abnormalities (fixed or variable) on myocardial scintigraphy at rest and after iv dipyridamole. Because of the costs and complexity, this evaluation of IHD was carried out in only 642 patients. The local Ethics Committees approved the protocol and all diabetic subjects signed an informed consent form.
Laboratory analysis
Urinary albumin was measured by immunoturbidimetry (Sera-Pak immunomicroalbuminuria; Bayer, Tarrytown, NY, USA; intra- and interassay coefficients of variation: 4.5 and 11.0%, respectively) (19) in either 24-h timed collections (N = 783) or random spot (N = 244) urine samples. The American Diabetes Association recommended that cut-off points were employed for the timed urine collections (normoalbuminuria: urinary albumin excretion (UAE) <20 µg/min, microalbuminuria: UAE 20-199 µg/min, and proteinuria: UAE ³200 µg/min). For spot samples, urinary albumin concentrations (mg/L) were used as previously validated in our central laboratory (19) (normoalbuminuria: UAE <17 mg/L, microalbuminuria: UAE 17-174 mg/L and proteinuria: UAE >174 mg/L). Glucose was determined by a glucose oxidase method, creatinine by the Jaffe reaction, A1c test by ion-exchange high-performance liquid chromatography (Merck-Hitachi L-9100 glycated hemoglobin analyzer, reference range 2.7-4.3%; Merck, Darmstadt, Germany), and triglyceride and cholesterol levels by enzymatic methods.
Serum insulin (radioassay, ElecsysR Systems 1010/2010/modular analytics E170, Roche Diagnostics, Indianapolis, IN, USA) was measured in a subgroup of patients (European descendants: N = 138, African descendants: N = 51) who were not taking insulin or insulin sensitizers and with serum creatinine <1.3 mg/dL. Insulin sensitivity was estimated by homeostasis model assessment-insulin resistance (HOMA-IR = fasting insulin (mIU/mL) x fasting glucose (mmol/L)/22.5), as recently validated (20). The mean HOMA-IR value of control subjects in our laboratory is 1.84 ± 1.02 (21).
Molecular analysis
DNA was isolated from lymphocytes using standard procedures (22). Subjects were genotyped for ENPP1 K121Q polymorphism in exon 4 aspreviously described (11). Briefly, a transversion from A to C at the first position of codon 121, resulting in an amino acid change from lysine to glutamine (K121Q) was genotyped. PCR was performed using primers: forward 5'-CTGTGTTCACTTTGGACATG TTG-3' and reverse 5' -GACGTTGGAAGATACCAGGTT G-3'. PCR products were digested by the restriction enzyme AvaII and separated on agarose gel. The genotypes were confirmed in a second reaction in 5% of the sample. All PCRs were run in a final volume of 25 µL, containing 50 ng genomic DNA, 20 mmol/L Tris-Cl, pH 8.4, 50 mmol/L KCl, 1.5 mmol/L MgCl2, 0.2 mmol/L dNTPs, 1 unit of TaqDNA polymerase, and 1 µmol/L of specific primer. The allele encoding the K variant appeared as a single fragment of 238 bp, and the allele encoding the Q variant appeared as two fragments of 148 and 90 bp each.
Statistical analysis
Continuous data are reported as means ± SD. Categorical data are reported as number of subjects and percent of individuals affected. The c2 test and one-way ANOVA were used to compare genotype groups in terms of clinical and laboratory characteristics and the Tukey test was used for post hoc multiple comparisons. Hardy-Weinberg equilibrium was calculated using allele frequencies and the c2 test. Variables without normal distribution were log transformed. The power to detect an odds ratio of 1.5 for DM in the presence of the Q allele was 70%, and the power to detect an odds ratio of 1.7 was 90%. A P < 0.05 value (two-sided) was considered to be significant.
Description of the subjects
A total of 1027 patients with type 2 DM (European descendants: N = 830, African descendants: N = 197) and 240 BD (European descendants: N = 149, African descendants: N = 91) were included. The patients of European descent with type 2 DM were older (59.3 ± 10.4 vs 54.3 ± 10.5 years, P < 0.001) and had a longer known DM duration (11.6 ± 9.0 vs 8.7 ± 7.2 years, P < 0.001) than patients of African descent. The BMI was similar for the two groups (28.9 ± 5.3 and 28.8 ± 5.4 kg/m2, P = 0.859). Among BD, mean age was 47 ± 7.8 years and gender distribution was 136 (56.6%) males and 104 (43.4%) females.
Genotype distribution
In both type 2 DM patients and BD, individuals of African descent had a higher frequency of the Q allele as compared to European descendants. In type 2 DM patients, the frequencies of the KK, KQ, and QQ genotypes were 25.9, 48.2, and 25.9% in African descendants, and 62.7, 33.3, and 4.1% in European descendants (P < 0.001). The same pattern was observed in BD (22.0, 53.8, and 24.2% for those of African descent and 61.0, 35.6, and 3.4%, for those of European descent, P < 0.001). However, the genotype distributions (P = 0.808 in European descendants and P = 0.653 in African descendants) and allele frequencies (European descendants: DM = 0.21 vs BD = 0.21, P = 0.966 and African descendants: DM = 0.50 vs BD = 0.51, P = 0.899) did not differ between diabetic and non-diabetic subjects, irrespective of ethnic background. All genotypes were in Hardy-Weinberg equilibrium.
Clinical and laboratory characteristics according to genotype
There were no differences in clinical or laboratory characteristics among the three genotypes (Table 1), except for DM duration that was longer in European descendant heterozygotes (P = 0.033). Systolic and diastolic blood pressure, prevalence of hypertension, glucose and lipid profiles, insulin resistance indices, and renal function did not differ among groups regardless of ethnicity. The prevalence of vascular complications (micro- and macrovascular) was also similar across genotypes.
Figure 1. ENPP1 Q allele frequency according to the ethnic origin. Diamond = mean; horizontal line = 95% confidence interval. *Data from the present study. DM = diabetes mellitus.
[View larger version of this image (135 K JPG file)]
Table 1. Clinical and laboratory characteristics of patients with type 2 diabetes according to ethnicity and genotype.
[View larger version of this table (276 K JPG file)]
In this sample of type 2 DM patients, the Q allele of the ENPP1 polymorphism had an increased prevalence among individuals of African descent. The same pattern was observed in healthy non-diabetic BD, suggesting that the Q allele is not associated with type 2 DM. The presence of the Q allele was also not associated with increased insulin resistance. Furthermore, there was no association of the allele of interest with chronic diabetic complications such as IHD, stroke, DM retinopathy or nephropathy.
The higher frequency of the Q allele observed among African descendants is in accordance with the few studies that evaluated K121Q polymorphism in different ethnic groups to date (Figure 1). In general, the Q allele is more common in populations of non-European origin (12,13). The Q allele frequency observed in African descendants in this sample (~0.50) is similar to that found in Dominican Republic type 2 DM patients (12). The Dominican Republic is a Caribbean island with a predominantly mixed population (European descendants: 16%, African descendants: 11%, and mixed descendants: 73%) (23). Unfortunately, the authors do not make any reference to the ethnic distribution of the Dominican Republic subjects studied. Based on the available information, we tend to assume that the majority may represent the mixed population. On the other hand, the frequency of the Q allele in the Afro-Brazilian descendants was lower than the frequency described in Afro-North American descendants (~0.80) (13). Among European descendants the frequency of the Q allele is relatively constant in the many different populations analyzed so far, with point estimates ranging from 0.10 to 0.21 (3-8,11,24-27).
We have previously described an association between the Q allele and diabetic nephropathy (11) in European descendant type 1 DM patients. In that study, the insulin sensitivity indexes were not assessed. However, the Q allele carriers did not differ with regard to phenotypic characteristics of insulin resistance, such as BMI, blood pressure, lipid profile, or A1c test values.
In this larger sample of type 2 DM patients, there was no association between the Q allele and clinical characteristics of insulin resistance, type 2 DM or chronic diabetic complications. Moreover, the indirect index of insulin resistance, HOMA-IR, was not different between carriers and non-carriers of the Q allele.
In a previous report, we have also found an excess of cases of end-stage renal disease and IHD in African descendant type 2 DM patients (28). The present data show that these excess frequencies cannot be explained by the ENPP1 K121Q polymorphism.
It is not yet clear why some investigators found an association of the polymorphism with insulin resistance and DM chronic complications, and others did not. Even among Europeans, this finding is somewhat heterogeneous (3-9,24). This suggests that, if the association is real, its effect is small and might depend on other polymorphisms or gene interactions.
The present report shares a limitation that is inherent to studies involving ethnicity: the classification of different ethnic groups. In spite of the use of patient self-reported classification, there may be some misclassification due to miscegenation. Nevertheless, the population of Southern Brazil has historically fewer inter-ethnic marriages than the rest of the country, probably preserving more of the original genomic ancestry. As a matter of fact, the Q allele prevalence among European descendants in the present sample is similar to that found in European countries.
The use of an indirect method to measure insulin sensitivity instead of the euglycemic-hyperinsulinemic clamp may be questioned, since it could reduce the accuracy of the results. However, HOMA-IR is widely accepted as an insulin action index (20,29), whereas the clamp technique is complex, time-consuming and not cost-effective for the study of large samples (30).
In conclusion, the ENPP1 polymorphism K121Q is more prevalent among Brazilian individuals of African descent independent of glycemic status or insulin sensitivity indexes. Likewise, insulin sensitivity and DM chronic complications appear not to be related to the polymorphism in this sample.
1. Bollen M, Gijsbers R, Ceulemans H, Stalmans W, Stefan C. Nucleotide pyrophosphatases/phosphodiesterases on the move. Crit Rev Biochem Mol Biol 2000; 35: 393-432. [ Links ]
2. Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, et al. A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities. Diabetes 2001; 50: 1952-1955. [ Links ]
3. Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37: 863-867. [ Links ]
4. Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999; 48: 1881-1884. [ Links ]
5. Gu HF, Almgren P, Lindholm E, Frittitta L, Pizzuti A, Trischitta V, et al. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes 2000; 49: 1601-1603. [ Links ]
6. Kubaszek A, Pihlajamaki J, Karhapaa P, Vauhkonen I, Laakso M. The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia. Diabetes Care 2003; 26: 464-467. [ Links ]
7. Rasmussen SK, Urhammer SA, Pizzuti A, Echwald SM, Ekstrom CT, Hansen L, et al. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. Diabetes 2000; 49: 1608-1611. [ Links ]
8. Gonzalez-Sanchez JL, Martinez-Larrad MT, Fernandez-Perez C, Kubaszek A, Laakso M, Serrano-Rios M. K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population. Obes Res 2003; 11: 603-605. [ Links ]
9. Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, et al. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. Diabetes 2005; 54: 3021-3025. [ Links ]
10. Kubaszek A, Markkanen A, Eriksson JG, Forsen T, Osmond C, Barker DJ, et al. The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. J Clin Endocrinol Metab 2004; 89: 2044-2047. [ Links ]
11. Canani LH, Ng DP, Smiles A, Rogus JJ, Warram JH, Krolewski AS. Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes. Diabetes 2002; 51: 1188-1193. [ Links ]
12. Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LM, et al. The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. J Clin Endocrinol Metab 2004; 89: 1359-1364. [ Links ]
13. Morrison JA, Gruppo R, Glueck CJ, Stroop D, Fontaine RN, Wang P, et al. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children. Metabolism 2004; 53: 465-468. [ Links ]
14. Chandalia M, Grundy SM, Adams-Huet B, Abate N. Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort. J Diabetes Complications 2007; 21: 143-148. [ Links ]
15. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 1998; 21: 518-524. [ Links ]
16. Carter JS, Pugh JA, Monterrosa A. Non-insulin-dependent diabetes mellitus in minorities in the United States. Ann Intern Med 1996; 125: 221-232. [ Links ]
17. IBGE. www.ibge.gov.br. Accessed February 22, 2007. [ Links ]
18. Costa LA, Canani LH, Lisboa HR, Tres GS, Gross JL. Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in type 2 diabetes. Diabet Med 2004; 21: 252-255. [ Links ]
19. Zelmanovitz T, Gross JL, Oliveira JR, Paggi A, Tatsch M, Azevedo MJ. The receiver operating characteristics curve in the evaluation of a random urine specimen as a screening test for diabetic nephropathy. Diabetes Care 1997; 20: 516-519. [ Links ]
20. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63. [ Links ]
21. Seligman BG, Biolo A, Polanczyk CA, Gross JL, Clausell N. Increased plasma levels of endothelin 1 and von Willebrand factor in patients with type 2 diabetes and dyslipidemia. Diabetes Care 2000; 23: 1395-1400. [ Links ]
22. Sambrock JFE, Mariatis T. Molecular cloning: A manual laboratory. Cold Spring Harbor: Cold Spring Harbor Laboratory; 1990. [ Links ]
23. Factbook. www.cia.gov/cia/publications/factbook/geos/dr.html# People. Accessed December 17, 2005. [ Links ]
24. Jacobsen P, Grarup N, Tarnow L, Parving HH, Pedersen O. PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients. Nephrol Dial Transplant 2002; 17: 1408-1412. [ Links ]
25. Abate N, Carulli L, Cabo-Chan A Jr, Chandalia M, Snell PG, Grundy SM. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. J Clin Endocrinol Metab 2003; 88: 5927-5934. [ Links ]
26. Abate N, Chandalia M, Satija P, Adams-Huet B, Grundy SM, Sandeep S, et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 2005; 54: 1207-1213. [ Links ]
27. de Azevedo MJ, Dalmaz CA, Caramori ML, Pecis M, Esteves JF, Maia AL, et al. ACE and PC-1 gene polymorphisms in normoalbuminuric type 1 diabetic patients: a 10-year prospective study. J Diabetes Complications 2002; 16: 255-262. [ Links ]
28. Gerchman F, Burttet L, Nabinger G, Picon P, Zanatta C, Lisboa H, et al. High prevalence of macrovascular and microvascular disease among black patients with type 2 diabetes mellitus. Diabetes 2005; 54: A548. [ Links ]
29. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 1999; 22: 818-822. [ Links ]
30. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487-1495. [ Links ]
Address for correspondence: L.H. Canani, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brasil. Fax: +55-51-2101-8777. E-mail: email@example.com
Research supported by PRONEX, CNPq, Fundo de Incentivo à Pesquisa, Hospital de Clínicas de Porto Alegre, and CAPES. Received June 21, 2007. Accepted September 13, 2007.


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Subaru WRX Forum (http://www.wrxtuners.com/forums/)
- Mid Atlantic WRX Forum (http://www.wrxtuners.com/forums/f79/)
- - WTT 03 RSX Type S for WRX ?? (http://www.wrxtuners.com/forums/f79/wtt-03-rsx-type-s-wrx-23734/)
WTT 03 RSX Type S for WRX ??
Looking to get rid of the rsx for a wrx. Car has about 61,000mi on it.
Mods include:
Megan Street Spec Coilovers,
Eibach Front/Rear Sway
RBC Intake manifold
Injen CAI
Hks Hi Power
Revo SS
BC Power Stabilizer
Located in Arlington VA PM with any offers.
Dude, I'm sorry but, LOL!!!
i'll give you my car + 5 grand for that sweet ride.
It's a legit trade, im trying to get out of hondas, im sure someone would like get out of subbies.
i would just put it all back to stock and trade it in on a subaru. then sell all that shit on acura to buy parts for the subaru
[QUOTE=sifrx;200769]It's a legit trade, im trying to get out of hondas, im sure someone would like get out of subbies.[/QUOTE]
I seriously doubt that second part.
You guys are cold. ;) Listen man, this is NOT the place to try to trade off your RSX. Try your local Craigslist. Or trade it in like said earlier. Then come back to us when you are ready to mod.! !Thumbs Up
Nagy's idea is really probably the best option you have. Doesnt sound too legit to me. I waited for 6 yrs to get into a subie, never going to see me out of them now.
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text:
Article Preview
MOSCOW OUTLINES RED BLOC'S LINKS; Document Hints No Move Against Common Market 'Division of Labor' Vital
By THEODORE SHABAD Special to The New York Times ();
June 18, 1962,
, Section , Page 7, Column , words
MOSCOW, June 17--The basic principles underlying the Soviet bloc's economic integration were published today. The principles are designed to achieve the goal of overtaking the capitalist world in total production.
June 18, 1962
Thank you for visiting The New York Times archive.
New York Times subscribers* enjoy full access to TimesMachine—view 129 years of New York Times journalism, as it originally appeared. 99¢ for your first 4 weeks.
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The 25th Annual Wright Patman Chapter Golf Scramble is May 27
The 25th Annual Wright Patman Chapter of Credit Unions Golf Scramble will be held Wednesday, May 27 at the Texarkana Golf Ranch.
The 25th Annual Wright Patman Chapter of Credit Unions Golf Scramble will be held Wednesday, May 27 at the Texarkana Golf Ranch.
I usually do not get into big political discussions or make soapbox statements regarding the state of our nation but this particular story really hit me as totally inappropriate. Appearances do matter when you are the leader of the free world and jumping into a golf cart within 10 minutes of holding a press conference to tell the nation about the horrible murder of an American journalist at the hands of a terrorist group...well I'm just not sure how to process this information.
Each has been called "Texarkana's Best" at one time or another so we wanted to ask you to make sure... which of these is really Texarkana's Best Golf Course?
What would you do if you where in the middle of a round of golf and a woman streaked through the course?
Texarkana loves golf! Some say it's the strategy which attracts them, but for others it's the element of relaxation. Well here is your chance to enjoy a game and help "Drive Away Hunger."
Golf as you know it is about to change.
There's something about golf carts that just brings out the bad driver in all of us.
The First Tee of Greater Texarkana is raising money by selling Caddy Passports for 2013.
Do you have something that you are passionate about besides your work and family?
A school board member in Tennessee finds himself under fire for creating a new invention he's dubbed the "Buttle Opener".
If you are new to golf or a seasoned pro, here are four public golf courses in Texarkana you need to check out.
Tiger Woods and a star studded field will tee of in The 'Masters' Golf Tournament today in Augusta Georgia.


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We have an old utility sink in our (main floor) laundry room and we'd like to remove it to install a cabinet instead. Question -- where will the washing machine drain into, if we no longer have the sink? We have septic, and a sump pump in basement. Does this kind of job require a plumber? Just wanting to understand the logistics. Thanks.
Christy in NJ


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Definition of devilish
Examples of devilish in a Sentence
She was attracted by his devilish charm.
There was a devilish look of mischief in her eyes.
Did You Know?
In the Septuagint, the Greek translation of the Old Testament, Satan is usually referred to as diabolos or "slanderer" (from the Greek verb diaballein, "to slander," literally "to throw across"). But in the Greek New Testament, the Hebrew word, which is Satanas or Satan in its Greek form, is used as if it were the devil's proper name. The older Latin translations of the Bible retain Greek diabolos as diabolus, but St. Jerome's version, the Vulgate, calls the devil Satan. Both words were borrowed into Old English, and we now call this figure both Satan and the Devil. The derived form devilish first appears in the 15th century.
15th Century
First Known Use of devilish
15th century
DEVILISH Defined for English Language Learners
Definition of devilish for English Language Learners
: evil and cruel
: showing a desire to cause trouble but in a way that is not serious
DEVILISH Defined for Kids
Definition of devilish for Students
1 : evil and cruel
2 : mischievous 2
Learn More about devilish
Thesaurus: All synonyms and antonyms for devilish Spanish Central: Translation of devilish Nglish: Translation of devilish for Spanish speakers Britannica English: Translation of devilish for Arabic speakers
Seen and Heard
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I made AIR Native Extension that can run java applications on Windows AIR.
The following image is a capture.
You can download the sample application on
How to use
- Please set jvm.dll path on your pc. Maybe 64bit Java doesn't work well. So please set 32bit jvm.dll
- Skip class name so far. I will explain
- Push start button. When you can see "java vm start" message, It means java vm start well.
- Push call button, then you can see current time strings on the screen.
The time was provided by java application.
If you access http://localhost:9991/ , then you can see current time strings on your browser.
- Push stop button, then java vm will be destroyed.
Inside a little
Please see the folder you installed the application.
Then you can see the following files or directory.
|- log4j.xml
|- *.jar
ANEj ( I named ) will call the following static method in the class you specified.
static boolean init();
static boolean start();
static boolean stop();
So If you want to try another java program,
Please change or add classes / *.jar.
( If you put some.jar on libs folder, the sample application add some.jar on the java classpath )
I will start ANEj project on Google Code, and add c code and as code in the near term.
Related Posts
One Response to "ane: Sample App for java application runs on Windows AIR"
Looking forward to seeing how you managed to accomplish this.


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Vogel Plant Biosciences Building
Named after pioneering scientist Orville A. Vogel, this building is a state-of-the-art home for researchers from several departments of the University, all focusing on plant science. The plant transformation core laboratory of the Center for Integrated Biotechnology is located here, along with scientists from four departments in the College of Agricultural, Human, and Natural Resource Sciences and a number of USDA-ARS scientists.
Interconnected research laboratories on the top three floors incorporate shared- and common-use equipment areas that encourage collaboration. Informal meeting spaces help people to get together to exchange ideas.
Public space on the ground floor includes four high-tech teaching laboratories. A preparation lab that provides additional flexibility for instruction and conducting experimental procedures supports each teaching laboratory.
View Campus Buildings in a larger map


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Weatherly, who has been with CBS Radio and KROQ for 20 years, has been recognized numerous times for his noteworthy achievements in the radio industry with awards, distinctions and honors from virtually every trade and music publication, including FMQB, Rolling Stone, Los Angeles Times, Entertainment Weekly, Los Angeles Business Journal, and the NAB, among others.
"Im thrilled to renew our commitment to Kevin who has been an integral part of CBS Radio for the last two decades," said Dan Mason, President/CEO of CBS Radio. "It goes without saying that he is one of the most influential and respected programmers in the music industry today. Kevin has guided virtually every station he has worked with to winning levels because of his instinct and willingness to take risks."
"During his time with CBS Radio, Kevin has transformed the landscape of music radio in the Los Angeles market," said Steve Carver, SVP/Market Manager, CBS Radio-Los Angeles. "He has the uncanny ability to cultivate and grow a station into a market leader, as evidenced by his work with KROQ, KAMP and KCBS. I continue to be impressed with Kevins attention to detail, his undying passion for music and loyalty to our audiences."
Nicki Farag, SVP of Promotion, Def Jam Recordings
Copyright © 2017 Friday Morning Quarterback Album Report, Inc. and Mediaspan Online Services - All Rights Reserved
Contact: Mediaspan Online Services
FMQB, 1930 East Marlton Pike, Executive Mews, Suite F-36, Cherry Hill, NJ 08003. (856) 424-9114.


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How to preview .eps files as thumbnails?
This is a discussion on How to preview .eps files as thumbnails? within the Windows XP Support forums, part of the Tech Support Forum category. We have a user who receives many .eps files. She would like to view them as thumbnails in Windows Explorer.
« Upload/Download Limit for different user accounts | What needs to be upgraded to make a slow old computer fast and nice? »


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Trixie91's Blog
Mon, Feb 13, 2012 at 9:41 AM
54th Annual Grammys- NICKI!!!!
I dont care wat anyone says...nicki looks like lil nicki wen she showed up in that red dress. I was like awwwwww!!!! MY TIME NOW!!! lol she looked jus the same to me it was soooooo cute. by the way all haters can suck MAJOR ziiiiicccckk! like Nicki doesnt care!! she does wat she does 4 herself & the fans. Long as her mama, her family, her friends & TEAMMINAJ accepts her FUCK a hater all day!! &...
Fri, Dec 2, 2011 at 12:46 PM
Pink Friday: Roman Reloaded 2.14.12
Fri, Dec 2, 2011 at 12:45 PM
It's been a year
oh yea shout out to me for being a memeber for 13months^_^ & happy anniversary to Pink Friday muuaahh!
Fri, Dec 2, 2011 at 12:44 PM
Roman In Moscow
Damn man.....our bitch is BACK!!! lmaoooo like she went somewhere....shooott haters was hopin she would but nick been had dis shit on lock boooiiii :)
Tue, Jun 21, 2011 at 4:55 PM
6/28/2011 Femme Fatale Concert
O M Gee!!!! Nicki will be here man. 7 days. Thats gona go by so fast!!! im not ready. Im so not. MAn i just dont want to faint. Pleeeaasssseeee. If i miss my moment on that reason I will not orgive myself lol
Sat, Mar 26, 2011 at 2:35 AM
Road block
People are weird now days & not that good weird eitha. Im talking about weird weird. I didnt do nothing to you therefore we should able to be cordial to one another & act like "ADULTS" not kids. I asked a simple question you had the answer but decided to brush me to the side right? Oh but then you need me too like less then 10 mins later tryna act all buddy buddy. Well i can detect fakeness...
Sun, Jan 2, 2011 at 7:19 AM
Fresh Start: The Beginning
Happy New Years! Its a new day symbolizin a fresh start. All the regrets, hate, n negativity of 2010 are thrown out. Time ta step up n make it bigger in 2011. Go afta goals that can be reached but wit hard work n effort put into it. Dont rush it; take it step by step n prepare urself. Follow ur dreams. They'll lead u down the rite path. *hugs & kisses*
Thu, Dec 9, 2010 at 4:04 PM
To All of My Friends
Hey evry1! Thanks 4 addin me. Dont b too shy ta holla at me :) im tryin ta get on more n i'll b comment n msg u guys soon so look out :) okaaayy muahh!
Wed, Dec 1, 2010 at 2:56 AM
yooo i hope i win da signed cd. im gona pass out 4rm excitement. plz plz :)
Sun, Nov 28, 2010 at 6:03 AM
My Time Now
Dont 4get ta watch Nicki's documentary "My Time Now" on MTV at 10pm/ct tonite.


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Princess PonyZ
By DesignZ by DeDe
More By This Designer
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Product Information
- Type: Embellishment Pack
- Designer: DesignZ by DeDe
- Download Size: 36.9 MB (approximate)
Design Elements
- Page Elements: 15
Designer Notes
What if all of your favorite fairytale princesses were ponies? What would they look like? Here's my take on some beautiful ponies with Princess cutie marks! Perfect for all of your Princess layouts and great for the horse-lover in your life!
Image Quality
High-resolution (print quality) JPG and PNG files (with transparency).
Download Options
Easy install directly into My Memories Suite software. Purchase My Memories Suite
General use installer for other software applications (i.e., Adobe Photoshop & Photoshop Elements, Paint Shop Pro, etc.).
Album and Photobook templates are intended for installation in the MyMemories Suite software only.
The General download will still contain all of the digital paper and page element files and template pages in a flat jpeg format so that you can recreate the template.
The layered pre-built pages are not available in the general download.
Download Access
All download options are available after checkout by clicking the "Access Your Downloads" provided on the order confirmation page. You may also access your downloads after logging into the My Account section located at the top right of the website.


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Steve Ballmer is heavily promoting Microsoft's wholehearted embrace of cloud computing, as evidenced by his sending out a memo to all Microsoft employees saying "when it comes to the cloud, we are all in." But that's not really the case. There are plenty of ways in which Microsoft doesn't truly embrace cloud computing, most notably in its upcoming release of Office 2010.
Ballmer recently spoke at the University of Washington, where he laid out Microsoft's vision for cloud computing. Here are what he called five "dimensions" of the cloud:
* The cloud creates opportunities and responsibilities
* The cloud learns and helps you learn, decide and take action
* The cloud enhances your social and professional interactions
* The cloud wants smarter devices* The cloud drives server advances that drive the cloud
He followed that up the next day with an email memo to all Microsoft employees about Microsoft's vision of cloud computing, with the subject line "We're all in." It lays out his five dimension of cloud computing, and is a kind of call to arms to all employees. The memo, first obtained by TechCrunch, includes this statement:
Today, nearly every one of our products has, or is developing, features or services that support the cloud. As I said today, when it comes to the cloud, we are all in. We are all in across every product line we have and across every dimension of the cloud.
However, when it comes to Microsoft's most important and publicized upcoming product launch --- Office 2010 --- there is no "all in" embrace of the cloud. It's more a half-hearted pat on the back.
As I point out in my Computerworld review of the beta of Office 2010, the Web-based version of Office 2010 is somewhat anemic. In Excel, for example, you can't add charts. In PowerPoint, you can't add backgrounds to presentations, and you can't add animations between slides.
True, there are some other very good cloud-based features, such as collaboration tools when using SharePoint. But leaving out basic important features of the Web-based version of Office is far from a whole-hearted embrace of the cloud.
Even worse is that Office 2010 doesn't include automatic synchronization of files between Web-based and client versions. So when you work on the Web version of Office, those files stay in the cloud, and when you work on the client version, those files stay on your local PC. You can save files from one to the other, but can't automatically synchronise them, something that Google Docs does.
This is a major shortcoming of the Web-based version of Office, because it will lead to an enormous amount of confusion, overwriting new files with old ones, and simply not knowing which is the latest version of a document that you're working on.
What's baffling about this is that Microsoft has two excellent, free synchronization tools designed for this very purpose --- Windows Live Sync, and Windows Live Mesh. It could easily tie them to Office, but chose not to. Again, that's not a wholehearted embrace of the cloud.
If Microsoft were fully embracing the cloud, it would also release a consumer version of the Web version of Outlook. Corporations have had a Web-accessible version for a while, but individuals don't. Microsoft could easily create a Web version of Outlook for consumers. If it truly embraced the cloud, it would do just that.
There's no doubt that Microsoft has recognized the cloud is the future, and it's clearly making a serious push into the cloud. But when it comes to one of its flagship products, Microsoft Office, it still has a long way to go.


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ED Magedson – Founder
Ripoff Report
Emerson (Funai)2200 Spiegel Drive Groveport, Ohio USA
Emerson (Funai) still have not sent me my repaired TV. It has been 7 weeks. Every time I call I get a different story. Groveport Ohio
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I purchased a 32" Emerson TV on Black Friday 2012. The TV went bad less that one year later in early October 2013. When I called Funai service they sent me a box to send the TV back in. They said that repairs take 2-4 weeks.
Funai rec'd the TV on November 4, 2013. Every time I called to check the status I was given a different story. When I would ask to speak to a supervisor I was told that a supervisor woud review my file and call me back. They never called back. I called at the end of November and was told that the TV would deliver by December 6, 2013. It never came. When I called to find out what happened they told me that Fed Ex put the wrong serial # on the tracking info and they could not find my TV.
They found the TV and said that the TV would for sure ship on December 16, 2013. When I called to get a tracking number I was told that the TV's were out of stock and that it would be 1-2 weeks before they are back in stock. I asked to speak to a supervisor and the supervisor told me that the TV's were out of stock but they came in on December 13, 2013. My TV should ship in 3-5 days.
I do not believe this. Every time I have called I have been lied to.
This report was posted on Ripoff Report on 12/16/2013 04:51 PM and is a permanent record located here: http://www.ripoffreport.com/reports/emerson-funai/groveport-ohio-43125/emerson-funai-still-have-not-sent-me-my-repaired-tv-it-has-been-7-weeks-every-time-i-1107488. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Success Stories: 2006
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He caught me totally off-guard.
God is so good and We are so blessed!!!!! Greg proposed to me on Saturday September 16, 2006! We are engaged!
We are getting married January 27, 2007!!!a brief story: We met online (catholicmingle.com) I sent him a virtual "smile," two years ago in September 2004 ... We talked online, on the phone, and through e-mail. In May 2005 we met in person (and we really hit it off!) In June 2005 Greg took me up to the foothills to show me his property up there and the next day he asked me to be his girlfriend (I said yes!!!!) We have dated with me living in Southern CA, the Bay Area, and now finally the Central Valley! We laugh a lot and enjoy spending time together. We visit friends and family often and rarely have too much spare time. We pray and go to church together. Our faith lives are very much on the same level. ... We fell in love ... In February 2006 Greg brought me back up to the foothills and told me he loved me!! It was the most romantic time we'd ever had. (I told him I loved him too!!!) We camp and hike and love spending time outside exploring God's creation. We have traveled all over Europe together and have made our way across the country visiting family and friends. We teach together for our church's confirmation students. ... Over the last year or so, we've had our ups and downs like any relationship has...but over that time we've learned what makes each of us tick, we've become friends and fallen in love. And we've learned that we share a common vision of our futures together...as a married couple, as parents of our future children, and as a Christian couple willing to go together wherever and do whatever God wants us to. In August 2006 Greg talked to his family priest and his parents, for a blessing for us to get married. The next weekend, we drove to Oregon to see my family and while I was out shopping with my best friend - Greg spoke with my father about his daughter and marriage. Of course, when my best friend and I came home dad and Greg were hugging in the living room. Two weeks later (Saturday September 16, 2006) - after much research on Greg's part to find the perfect ring, much planning on his part to plan the perfect proposal, and much anxious anticipation on my part!!!! - He caught me totally off-guard and made it a complete surprise!!! He proposed. Many of you have already asked how he did it and please call me if you want the 20 minute explanation! But to be brief - it was perfect! He brought me to our church, to the statues of the Holy Family, to light a candle and pray. He prayed for us and for our future together. It was amazing (ok, now I am all watery-eyed at work writing this!!!) He got down on both knees, said all sorts of sweet things to me, and asked me to marry him! (OF COURSE – I said yes!!) The priest had left a blessing for us and since we were alone in the church we cheered and danced around, very excited! We called around to share the good news and spent the rest of the weekend relaxing and celebrating with family and friends. Prayers are heard (I can't even count how many novenas to St. Joseph I have prayed!!) and dreams do come true!!! Our God is truly an awesome God!Blessings to all of you.
sarina & greengreg
I proposed. And she accepted!!
As a widower, I had decided to stop looking for someone. For several years I had worked hard at trying to find and share my life with the right woman. But, I figured the Lord's message to me was clear - 'This is not the path I have planned for you.' Then one afternoon, not too long after my acceptance of the Lord's will, in July 2005, Pam's profile and picture appeared from Catholic Match with an 87% match (unheard of for me)! [When my profile appeared on her screen it was with a 93% match!!] Also, the personality profile coloring started us off well. I thought, "Wow! Well, maybe He has opened a door. I will take a chance and walk through!"
My first introductory e-mail was on July 14, 2005; Our e-mails were great. Pam revealed herself to be an intelligent, accomplished, Catholic woman of grace and kindness. After several months we met for dinner on Sep 4, 2005. When she walked in the restaurant door, I was smitten - all that and beauty too. From the first there was a great attraction and shared interests. The dating turned into courting, on my part, within no time. We are both grateful for Catholic Mingle for bringing us together.
Even though we live in the same city (30 minutes apart), it is doubtful that we would have ever met if not for Catholic Mingle. The Lord continues to bless us as we build our relationship and learn more and more about each other. The future is in the Lord's hands, but we are counting on His blessings on us.
I proposed. And she accepted!! We became engaged on September 16, 2006. The wedding is scheduled for April 14, 2007. We are very involved in wedding planning at his time.
RichardB & Amazing2U2
We prayed for someone to come into our lives.
Ed (Papa) and Joan (JoanE) will be married on October 28, 2006 in a Catholic Church in VA. We met on Mingle in October 2005. We became engaged on Valentine's Day 2006. We are looking forward to a honeymoon in Rome and Florence, Italy in November 2006. We received tickets to attend a blessing by the Pope for newlyweds that we will attend while in Rome. You can view a picture of us on JoanE profile. We will put a Wedding picture on JoanE profile sometime in the future before leaving this site after we are married. We are older adults and prayed for someone to come into our lives after the death of our spouses. Prayers are answered. We thank Catholic Mingle for bringing us together.
Best Wishes,
Ed and Joan
JoanE & papa
I knew she was a keeper.
Militza and I met through a brief chat session on Catholic Mingle.
Initially, she turned me down. Absolutely gave me the ultimate no-no. She looked at my profile, saw that I had red hair and said, "See ya." Only, her response to decline was a lot more polite. Her decline message came back to me as she was "busy at the time." She tells me now she was trying to be polite, but that she
really didn't care for guys with red, or in my case, auburn hair. Catholic Mingle's site didn't provide an option for my exact hair color, at least not that I can remember when I initially became a lifetime member. Militza says it's almost lighter than strawberry blonde. Either way, it almost cost me the girl of my dreams.
That was when I tried to IM her while we were both online at the same time. After waiting a while following her ultimate shut-down to accept my invitation to start up a conversation, I asked her again, my instincts telling me she had "enough time" to finish what she was doing. This time she accepted.
We hit it off right from the beginning. One of the first things she said to me was she knew if she ever got married she would never get a divorce. When she told me that, I knew Militza was worth pursuing. I knew she was a keeper. I had been saying those exact sentiments to different girls, and never got the same
response back. Or at least the response I was looking for. This time, I didn't have to do the work. Militza did it all for me, and pretty quickly.
We were talking on the phone that night. Initially, when I asked her for her phone number, she said, "I have two. One with a tone and one without." I'm briefly scratching my head, although I knew there was one good phone and one bad. Yeah, I want the one with
a tone, I told her. What she was meaning to tell me was that one worked and one didn't. My thoughts were, yeah, I want you to hear what I'm saying.
So that night we talked until about 2:30 in the
morning. Well, 2:30 a.m. for her -- she lives in
Bethlehem, PA. I lived in Phoenix.
Needless to say, after a couple flights from Phoenix to Philadelphia, which is about an hour away from Bethlehem, some coaxing from her large Puerto Rican family and the right timing, I moved here, where we are now engaged. She flew out to Phoenix to drive back across the country with me, and we made a stop in the Grand Canyon, where we got engaged on Aug. 18, my grandpa's birthday. I was named after my grandpa,
James Francis. I didn't plan it that way
intentionally. It just sort of worked out. We later asked her parents for permission -- something she "politely" insisted, and after staying with her family for about a month while living here, I proposed to her on her 34th birthday, Sept. 20, 2006, following long
day, which included a short trip to Atlantic City.
Already, we've been to Baltimore, New York City,
northern Virginia and Atlantic City together. We've traveled across the country from Arizona through New Mexico, the panhandle in Texas, Oklahoma City and Tulsa into Missouri. At the border of Oklahoma-Missouri, my new car ran out of gas after 1 a.m. and we had to sit for a little over an hour, waiting for roadside assistance. It was a lesson in patience, but the long wait also taught me not to test my tank. We had a great time in St. Louis and then drove up into the metro Detroit area in Michigan, where she met my family. They all love her very much.
We have seen many places together, but so far, the Grand Canyon is very special for obvious reasons. A few of the photos of us were taken in the Grand Canyon.
We are planning a May wedding and beginning our future together now. Living separately, of course.
Hey, we're Catholic.
Militza and I both want to thank Catholic Mingle for making this connection possible.
We'll never forget Catholic Mingle ...
mccurdy & tweetie72
We are getting married September 8
It is with great joy that "seemerun" and I ("cephas101") announce we are getting married September 8, as it is the Birthday of Our Lady. Seemerun, who lives in Tucson, is a RN and will continue her work as a NICU nurse in Tulsa, after we are married. Although I am retired, we will also work together building a combination of a ranch and a farm near by. We will use the ranch in a apostolate for the Lord and Our Lady..
We wish everyone the best. We both want to say, hang in there because God has someone picked out special for you. Just be patient, pray and wait; then everything will fall into place in God's time.
Praise be God!
In Jesus and Mary,
seemerun and cephas101
cephas101 & seemerun
The Mingle is the bomb!
The Mingle is the bomb! Charger and I met last August. Just a day after I had joined, he got an alert in his mailbox that I was a match. Initially, I discouraged him from continuing to correspond. I was 445 miles south in the L.A. area and he was up in Sacramento! How could I hope to have a meaningful relationship with someone at such a distance? I suggested we just swap e-mails as friends.
We e-mailed back and forth for a couple of weeks and the attraction just flourished and grew. It was so compelling. We had so, so much in common - certainly our faith and Catholic values - but also our appreciation for sharp, profound discussion tempered by compatibility and irreverent senses of humor. We shared a complex and magical chemistry from the beginning. It almost felt too good to be true. We were ultimately determined to see if the intellectual attraction and the real life, up-close-and-person reality could actually co-exist . . .
Finally, we agreed to meet in person. We each drove four hours and met in a little town in central California. We talked all night! No one would have imagined that we'd only just met in person for the very first time. From then on, we arranged to see one another every two weeks. Over time, even that wasn't often enough. We have kept Southwest airlines in business between the two of us and our frequent flyer miles.
Inevitably, our discussions turned more serious. We discussed the possibility of marriage on a few occasions. The big day came when Charger popped the question on the shore of the lake at South Lake Tahoe. The sun had just set in the twilight sky. The stars were just beginning to twinkle. We admired the snow-capped peaks surrounding us. Turning to sit on a bench in the sand, I took a seat as Charger surprised me by kneeling down on one knee and proposing marriage. I accepted, and we plan to be married July 8, 2006!
We are so humbled and awed by God's abundant blessings and love upon us and our children in bringing us together. Thank you so very much to Catholic Mingle for providing a wonderful, dynamic and faith-centered environment where like-minded individuals can meet, share and enjoy the kindness and love of others -- and perhaps even find the love of their lives. Wow!
The Mingle is fabulous! I met and married my beloved Charger from right here on the good ol' Mingle this July, 2006! I'm officially happy, hitched and having the time of my life! Best of luck to everyone. Catholic Mingle is wonderful!!!!!
Parizienne & Charger
We were married on January 28, 2006
Celticfan and I started emailing and IM'ing in September of 2005. We quickly realized that we had a great deal in common, thanks in part to the profile system offered on Catholic Mingle. Because we knew about each others likes and dislikes before we ever emailed, it made getting to know each other a lot easier. When we decided to meet for dinner, it was like meeting an old friend, and falling in love at first sight! We knew enough about one another to know that this first meeting was going to be the make or break, and I am very happy to say, we were both very pleased with the results. We were married on January 28, 2006, and have started blending our 2 families and look forward to many years of happiness and joy together.
Kpzolo & Celticfan
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The development and continuous improvement of movements, functional displays and cases has been part of IWC's philosophy since 1868. Complications such as the perpetual calendar, constant-force tourbillon and minute repeater are not only historically significant achievements in the art of watchmaking but also the fruit of the company's in-house design and development efforts. With the video series "The Man's Guide to Haute Horlogerie", which consists of 7 episodes dedicated to iconic complications, IWC gives you an insight into the world of Haute Horlogerie made in Schaffhausen.
Date — 2012-12-19T13:55:52
Haute Horologerie, or High Horology in English, literally means "high watchmaking". In a sense, all fine watchmaking is "high" – producing a fine watch at IWC Schaffhausen requires finesse, skill and meticulous craft. But the finest of the finest of these mechanical watches are the great and intricate complications, which are considered the masterpieces of watchmaking. At IWC, this means Tourbillons, Perpetual Calendars, Minute Repeaters and Grande Complications, which bring together all the highest horological complications in one watch.
These complications require not only hours but also days or even weeks to carefully assemble. Tourbillons counter the effects of gravity by mounting the central movement components, the escapement and balance wheel, in a rotating cage. Getting the movement to essentially revolve around itself is no mean feat; there are minuscule parts that need to be perfectly assembled and adjusted.
The same is true for Minute Repeaters, which are watches that chime the hours and minutes. Tuning the parts so the hammers chime melodiously, and exactly on time, requires skill and artistry. Grande Complications, as their very name indicates, are especially complicated. At IWC, they not only have Perpetual Calendars, plus a Chronograph telling elapsed time, but also a Minute Repeater.
But even these watches are exceeded in complexity by the Portuguese Sidérale Scafusia. It is the most complex timepiece ever created by IWC Schaffhausen, and tells traditional or solar time, plus sidereal or – star time. Beyond having a patented constant-force tourbillion revealed on its dial side, the Portuguese Sidérale Scafusia shows on its reverse side the night sky with hundreds of stars, visible from a precise location on Earth, together with the apparent orbit of the Sun in the course of the year, and the celestial equator. These are joined by a perpetual calendar showing the absolute day of the year, plus the times of sunrise and sunset.
All these complicated watches are at the apogee of fine watchmaking. They are more than complicated instruments, but also they are works of great art. And the watchmakers who make them are not just technicians, but also artists. Their contributions help define the meaning of Haute Horology today.
At IWC Schaffhausen, there is a special department, essentially an atelier-within-an-atelier overlooking the Rhine, that exclusively produces these masterpieces. At the helm is Hansjörg Kittlas, a technical expert, a fine watchmaker, but also a true artist who is refreshingly down-to-earth. Mister Kittlas is an especially approachable person, and perhaps younger than you'd imagine given the sophisticated engineering embedded in these watch movements.
—Hansjörg Kittlas about the love of this life - the minute repeater
Kittlas was born to be a watchmaker. From his early childhood in then East Germany, he aspired to watchmaking. When he was a teenager he was taught by a private watchmaker in Saxony. He attended State school, alternately attending school one week and working the next. On the last day of class in 1994, his teacher wrote on the board "Lange is searching for young people to do more".
But back then, Lange & Söhne apprentices were first taught at IWC, and the young Hansjörg Kittlas didn't wish to spend a year in Switzerland. So he worked for another company in Dresden, until he was invited to apply again at Lange in 1995. He was interviewed in Schaffhausen by Ronald Jäger, Executive Director of Production at IWC Schaffhausen. The test was simple: take apart and reassemble a relatively basic 30110-calibre movement.
The rest is, as they say, history. Hansjörg Kittlas started immediately, and soon became a member of IWC's perpetual calendar department. Apparently Ronald Jäger really knows talent, and Hansjörg Kittlas, in his own self-effacing, quiet way, made an impressive career in Schaffhausen. Today, he heads up the small group of watchmakers who constitute the high complications atelier, producing Grand Complications, Minute Repeaters, Tourbillons and the especially rare Portuguese Sidérale Scafusia.
The small department assembles these technically rich and complex movements. The skill and patience of each watchmaker here, as he or she configures and reconfigures the minuscule parts is extraordinary. The ultimate goal is that every watchmaker in this special department should be able to work on all these movements. But the different watchmakers understandably have their own specialties, and for Mister Kittlas, it's the minute repeater.
Talking to him, you can tell that Hansjörg Kittlas loves these watches. He understands all their intricacies and he's always excited each time that a repeater first chimes as it comes to life. So does he, as a true artist, wear a repeater that he painstakingly created?
Actually, Mister Kittlas wears a simple IWC Porsche Design model from the 1980s –for one outstanding reason. It was the engagement present from his fiancée, now wife, when he was a junior watchmaker. As he so engagingly says "there's no need for champagne for breakfast".
Hansjörg Kittlas is a totally unaffected watchmaker, a charming and forthright guy, who simply makes incredibly complicated and great watches. For the connoisseur, for the haute horologist, these works of art are far better than champagne. Herr Kittlas and his talented team make the best of the best.
The development and continuous improvement of movements, functional displays and cases has been part of IWC's philosophy since 1868. Complications such as the perpetual calendar, constant-force tourbillon and minute repeater are not only historically significant achievements in the art of watchmaking but also the fruit of the company's in-house design and development efforts. With the video series "The Man's Guide to Haute Horlogerie", which consists of 7 episodes dedicated to iconic complications, IWC gives you an insight into the world of Haute Horlogerie made in Schaffhausen.