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Last year at this time I spent a few days as a road racer at La Vuelta de Bisbee, a three-day, four-stage road race in Southern Arizona. I decided to up the challenge this year and gave the Tour of the Gila in Silver City, NM a go. This race is one of the premier domestic NRC races, and a number of the top women's teams are represented. And Kristin Armstrong raced, enough said.
I'll go ahead and lay the racing facts out on the table:
Overall GC: 32nd
Stage 1: 23rd
Stage 2: 34th
Stage 3: 44th
Stage 4: 31st
Stage 5: 22nd
Bee stings: 2
Elevation: 6,000+ ft
I planned for a good ass-kicking (aka training) going into the race. I guess I got what I signed up for. Stage 1 started on the flats with a few rollers and ended on a Category 1 climb 73 miles later. In road racing, there are always critical moments when you have to go or not go. Simple. I usually make a decision, and in retrospect I wonder, "what was I thinking?" Those missed-moments defined my first Gila. The climb on Stage 1 had a mile-long flat windy section on the way up. I wound up chasing the lead group through this section. I didn't really know where the flat section was, and when pace upped another notch beforehand, I decided to "not-go" thinking I wouldn't last. Bummer. Around the next corner, the wind hit, the grade flattened, I had no draft = dropped. I missed my chance to sit in and take a breather.
Stage 2 "The Inner-Loop Road Race" is the beast of the Women's 1-2 race with 3 categorized climbs in 78 miles. A group of 9 women rode away on the first major climb, and I hung on in a chase group of about 15. The groups came back together some time after the infamous "Sapillo" descent. Team Webcor drove the pace since their sprinter was in our group. They also drove the pace through the last feed zone (11 miles to go!) which resulted in my getting dropped #2. Since I was out of water at that point and anxious for more, my thinking was "get bottle." Once I had my bottle, I was dropped. Another reason why road racing is hard: the feed zones are fast. I also got stung by a bee while changing after the race, and that was the first time in my life that that has ever happened.
Kristin Armstrong blew away the existing time trial course record by over a minute. I got stung by another bee 2 minutes in. If I could learn to tolerate the uncomfortable (and painful) position, I think I could learn to like time trials. The criterium was pretty uneventful except I never found the lap counter out racing and never knew how many laps we had left. Carla Swart, a fellow student-athlete won the criterium which is pretty impressive. On the last stage, things went pretty well. Amazingly, I still had something in the tank for the "Gila Monster Stage." I managed my best power output for the week on the last climb and won my group sprint.
The best part of the week was having my sister around to feed me bottles (and cook). She drove all the way down from Vancouver, BC for the event. She took some pictures through the week and I'm still trying to get a hold of a few of them. She's got some talent with a camera. Check it out: shannonforsman.com
Up next: Collegiate Road Nationals in Fort Collins, CO.


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Edwin F. Williams, III, MD
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5 out of 5 stars Rhinoplasty
Rhinoplasty and Chin Implant - Latham, NY
I had considered having my nose done for about five years and finally went to a consultation with another plastic surgeon in another practice and wasn't comfortable with it. About a year later after researching more doctors and practices I met with Dr. Edwin Williams and I finally felt for the first time 100% confident in what I wanted to do. He helped me come up with a plan to achieve the goals I had in mind. He explained how the proportions of my facial features affect one another and I ultimately decided on a rhinoplasty and chin implant. Dr. Williams made me feel absolutely comfortable every step of the way and always listened to me and took my concerns seriously. The staff was also incredible and while very professional also truly down to earth and caring. Before and after my surgery I felt I was very well taken care of and it made the healing process easier. Every time I had a concern or question the staff and Dr. Williams were wonderful. After a couple of weeks when I started to see results and throughout the next year I became more and more satisfied with the results. Dr. Williams knew exactly what I wanted and he made my face look amazing, even better than I had imagined. I am truly grateful to have had him as my surgeon and would never consider going anywhere else. He truly is the best and a year later I am still very grateful to him and his practice. It truly changed my life. You cannot put a price on self confidence and I feel like a new person.
5 out of 5 stars Lower Face Lift
Very Happy :) - Albany, NY
Dr. Williams did an extended weekend lift on me and the results are awesome. I am very happy and it was worth every penny. If you don't like your neck and jowels, book a consultation. He knows what he is doing and you won't regret it. I see a huge difference in my profile and am much more pleased with it now.
5 out of 5 stars Eyelid Surgery
50 and Feeling It! - Latham, NY
Dr Williams was professional, kind and very patient as i asked many questions. We discussed my surgery several times and everything went exactly as he said it would including the recovery. I loved that he offered to let me speak with a prior patient who had the same surgery. That was very helpful. I would highly recommend him to everyone.
5 out of 5 stars Rhinoplasty
23 Year Old Female - Albany, NY
Dr Williams' level of genuine concern and skill was evident from the first appointment thru the entire course of being under his care. He made it clear his goal was my total satisfaction, and after the initial procedure I had two additional visits to tweak things and ultimately things were perfect. He never rushed you and made you feel you were the most important patient he ever had. He is genuine and caring and I couldn't be more pleased with him as my physician.
5 out of 5 stars Facelift
52 Years Old, Lower Face Lift and Neck Lift - Albany, NY
Awesome experience. Would not go to anyone else. Wonderfully professional and still personal experience.
5 out of 5 stars Facelift
I Look the Best I Ever Have! Latham, NY
Dr. Williams has the uncanny ability to be down to earth yet a highly educated and certified surgeon. He comes across as a precise and skilled surgeon. He described the procedure in terms I could understand and answered my questions with such patience - questions I am sure he has been asked a million times!
5 out of 5 stars Neck Lift
Look Like Myself Again. Latham, NY
I was tired of my saggy neck and wanted to look like myself again. I am very pleased with the results. The change is very subtle so I don't look very different, just better. Dr. Williams and all the staff were kind, thoughtful and supportive throughout the whole process. Whenever I had a question or concern I was able to either to be seen in the office or get an answer right away.
5 out of 5 stars Rhinoplasty
Thoroughly Pleased. Latham, NY
Growing up I always thought the shape and size of my nose never fit my face. Dr. Williams made a nose that naturally better flatters my specific facial features to completely change the way I look. If you are considering seeing Dr. Williams for a rhinoplasty I definitely encourage you to do so. He took the time to really listen to what I wanted and answered all the questions I had. It is...
5 out of 5 stars Eyelid Surgery
66 Years Old with Droopy Eyelids. Latham, NY
As described above, Dr. Williams was very involved in all phases of my treatment. He was approachable, sincere and extremely talented. I couldn't ask for anything better. I have recommended him to several friends already.
5 out of 5 stars Facelift
Multiple Procedures. Dr. Williams Worked with Me Until I Was Happy - Latham, NY
Dr. Williams (and his entire staff) was always willing to listen to me. He is a very talented surgeon and a very kind and caring person.
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You missed it This great deal for My Island Spa is over. But don't despair, we've got more great deals every day.
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What You'll Get
Treat yourself to a Complete spa package -- your 90-minute appointment will include a one-hour massage, a soothing facial, and a relaxing scalp massage to bring ultimate relaxation benefits. Or, opt for the Ultimate package, which includes a one-hour massage, 30-minute foot scrub, a reflexology session, and a hot stone therapy treatment. Located inside Nueve Salon & Spa in Honolulu and in Hauula.
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1303 Ivy Road
Bremerton, Washington, 98310
Commute to Downtown Silverdale
Most errands can be accomplished on foot.
A few nearby public transportation options.
About your score
1303 Ivy Road has a Walk Score of 72 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
This location is in Bremerton. Nearby parks include Bataan Park, Stevens Canyon Park and Illahee Forest.
Explore how far you can travel by car, bus, bike and foot from 1303 Ivy Road.
1303 Ivy Road has some transit which means a few nearby public transportation options.
Bus lines:
15A McWilliams Shuttle - All stops to McWilliams.
0.1 mi
13 Parkwood East Limited
0.1 mi
15AC McWilliams Shuttle - All stops to McWilliams. Crossroads P&R.
0.1 mi
15 McWilliams Shuttle
0.1 mi
23 Kariotis/Tracyton
0.1 mi
21 Perry Avenue
0.1 mi
11 Crosstown Limited
0.2 mi
25 East Park
0.2 mi
17 Silverdale East
0.2 mi
View all Bremerton apartments on a map.
Popular apartment searches include fireplace, single family and hardwood floor.
Search for homes in Bremerton or find a Bremerton real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
This location is in the city of Bremerton, WA. Bremerton has an average Walk Score of 48 and has 37,729 residents.Learn More About Bremerton


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Does anyone out there want to be mayor of Vancouver? Anyone? Anyone?
That's the question increasingly making the rounds among political insiders, as three parties are on the hunt for that vitally important, brand-defining, headline-generating leader in this year's election campaign.
That quest is particularly important for the once-dominant centre-right Non-Partisan Association, a party that ruled the city for most of a 70-year period up to 2002, but no one appears to be putting their hand up.
In recent elections, the party suffered painful defeats under mayoral candidates Suzanne Anton in 2011, Peter Ladner in 2008 and Jennifer Clarke in 2002.
It squeaked out a victory under Sam Sullivan in 2005.
This year, city voters are irate over development plans, bike lanes, a nasty community-centre fight and a general sense that no one is listening to them. Some are looking for an alternative to the Vision Vancouver party and Mayor Gregor Robertson, and the NPA is mounting a particularly energetic hunt in a quest to regain status.
"Our top priority now is finding our candidates," acknowledged Natasha Westover, a paid staffer for the NPA. "A lot of people see this as a change election."
"We're looking for somebody who's a leader and will stand up for Vancouver, somebody's who's successful in their own right and somebody who's community-minded."
So far, there appear to be no public takers, at least among the names mentioned by party insiders and close observers of the political scene. That's even though NPA president Peter Armstrong is said to be making extensive recruiting efforts with former Canuck star Trevor Linden, ex-B.C. finance minister Carole Taylor and others.
Among the names circulating, the responses have been mostly negative:
Former Vancouver police chief Jamie Graham, just retired four weeks ago as Victoria police chief, noted: "It's just not in the cards."
Said Tourism Vancouver CEO Rick Antonson, who will be leaving his job of two decades in a few months: "I care passionately about this city but don't have any interest in that." His plan is to become a full-time book writer.
SFU Chancellor Ms. Taylor, a perennial favourite in the mayoral-candidate rumour mill, ends her term there in June. But she said "while I have been approached by a number of people to run for mayor, my answer to everyone is the same: As chancellor of SFU, I am apolitical."
Colin Hansen, another former B.C. finance minister, isn't interested: "After 17 years of that workload, that is enough for one lifetime."
And former Vancouver-Fairview MLA and health minister Margaret McDiarmid said it's not her thing: "It's not the area of politics I was ever interested in."
Three people whose names are currently in rotation didn't respond to requests for comment. They include former Vancouver Olympics organizing committee chief John Furlong, who has been dogged by controversy recently, Mr. Linden and current Vancouver police chief Jim Chu.
Mr. Chu just tweeted a friendly picture of himself with Mr. Robertson on Sunday at the Chinese New Year Parade. Bob Ransford, a former NPA campaign organizer, said he doubted Mr. Furlong would be interested. "I know John and that would be the last thing he wants to do."
Finding a strong mayoral candidate is key for a party that has any serious ambition to get seats on council.
"The mayoral candidate is the flag bearer for his or her party, is able to crystallize the issues and shape the campaign," said Tim Louis, chair of the left-wing Coalition of Progressive Electors. His party decided late last year to run a mayoral candidate against Mr. Robertson. That was an open declaration of war against Vision Vancouver, after two elections where COPE co-operated with Vision and only ran council candidates.
TEAM, a new party, is also hunting for a mayoral candidate – something that will make the difference in whether it is taken seriously on the civic scene.
"It's that star status. It shows weakness in a party if they can't muster a leader," said Mr. Ransford, who ran Mr. Ladner's campaign in 2008 but has been decidedly more Vision-friendly in recent years.
The leader, especially, matters to the big donors.
"They assess the viability of a political force based on their leadership. If you don't have that, they're not going to bet on you."Report Typo/Error
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I believe the concept of a "public nuisance" has a specific legal meaing.
It's more than just annoying an individual person. It really has to be a nuisance to the community at large. It would seem that if your direct neighbors don't feel threatened by your bees that proving a public nuisance could be difficult.
I found quite a few references to definitions of public nuisance on the web. They all seemed to say the same thing. But then I'm not a lawyer and have never even been on TV as a lawyer or anything else.
Maybe there IS a lawyer lurking around the site that could give some better insight.


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BYRD'S LONE VIGIL FEARED BY RUPPERT; Expedition's Backer Sends Radio Message Urging Leader to Return to Base.
Colonel Jacob Ruppert, who has given extensive backing to the Byrd Antarctic Expedition, sent a radio message to Admiral Byrd yesterday urging that the explorer give up his plan of spending the Southern Winter alone in a hut 123 miles south of Little America.
April 07, 1934
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Would you like to save as your currency permanently or for this visit only?
Au 30
30 rue Paul Duez, 59800 Lille, Nord-Pas-de-Calais
0.3 km from
Rp 1,760,000+
Great location, very quiet despite proximity to station. Easy parking underneath. Excellent rooms, clean and functional.
Mattress and pillows very comfortable. Breakfast - scrambled eggs cold. Gluten free choice limited and GF muffins were mouldy. Room temp difficult to regulate.
excellent location near the station and the city center; also very close to Euralille, which is a great shopping center; clean room; good breakfast My room was way too noisy because of the dysfunctional closing system of the window ; I was also very disappointed because the staff at the reception desk was not only unfriendly but also very rude.
Excellent facilities. Very large rooms which were clean and very comfortable. Excellent facilities onsite with bar and good priced restaurant. Internet available. Friendly staff. Good location, only 5 minute walk to center of Lille.
Close to railway station Lille Flandre
The check in was simple and the clerk was very efficient, extremely helpful and polite. The rooms were clean and the bed comfortable, and great stay with the hotel located a short walk from the Old Town and the Christmas Market. Wide range available for breakfast, but the hot food offering was limited and cold
The hotel was fine but nothing more. The location was the best point Very basic. Bed was bad and breakfast awful.
We liked the location of the hotel. The staff were very friendly and helpful
clean modern hotel ,convenient for SNCF/ Eurostar breakfast seemed expensive.
Not very good location and no car park!!
Comfort of the rooms and the vast range of breakfast items
The accommodation was comfortable and the kitchenette well equipped. Despite its location near a major road network, it was surprisingly quiet. This may be, however, because our rooms faced away from this network. We were attending an event at the Grand Palais, for which the location was ideal
Room was a good size, clean and new. Shower and bathroom were excellent. Bed/couch fold up was uneven and therefore uncomfortable.
It is situated close to Grand Palais For us was it very important that it is close to the Grand Palais and that there is a parkingplace availabel
very new hotel / appartment-style accomm. The fittings were new and there is still a new-paint smell to the place. 8 minute walk from the Lille Grand Palis Metro stop. 20 Minute walk from museum of fine arts. Very difficult to find!! It is a new hotel (thus unlisted on any of the guides in town) and it is on a newly constructed road which is not shown on ANY map in town. It took me over 2 hours to eventually get to the hotel from the Metro, and that was because the hotel staff came and (eventually) found me.
Easy to check in, clean and good value for money. The bed was a little too firm
Rooms are equipped with kitchen and kitchen utilities. Sleeping rooms and bathroom are ok. Hotel staff are not very friendly. They are available only on working hours, so if you arrive after 7pm or on weekends, be sure to talk with them by phone before.
Excellent facilities facilities in Studio Directions were useless. From the Metro station It took me over one hour to find the place, which is in the middle of a huge building site. Even the local Police station had never heard of it>
they rooms are nice and clean and your value for money is good. The rooms are nice and quite so you dont hear the traffic from tthe motorway.
They have most of the things we need to make our own meal in the room, giving me feeling of staying home. The place was difficult to find even with the aid of my GPS. Surrounding are all building sites made it quite dangerous to driving in and out from there. Instead of pushing one of the buttons for the following 2 questions, I would give my comments here. To the question of whether I dould recommend this hotel, I can only do so when the surrounding environment is improved. To the question of whether the guest review accurately reflect my experience, since I did not check ose reviews, I could not give any answer.
Hotel was clean, refurbished. Close to the center of Lille. It took two hours driving arround to find the hotel. Then it appered that address was changed. At the main entrance to the street there was a sign --there is no entrance --. No receptionist - you have to call to get the pin code to enter and to get the pin code to get your kee
the room was very good value for the price location was vey "dubious"
Close to center. The heating was on during the night, we are not used to hot bedrooms.
Closeness to Eurorail station, staff very good no problems
Good secure parking, helpful staff, beds were actually comfy and they had decent new showers! right near the metro as well. it was very quiet and therewas no one on the bar!
Location, cleanleness, value
the service at the breakfest was poor. The breakfest too
Shower was good. Out of 4 of us 3 had severe food poisoning after eating in the hotel restaurant, stay away from the fish!!! Only 2 TV stations, location is a bit dodgy.
The hotel was ideally located within a 10 minute walk from Lille's Eurostar station and just 15 minute walk from the City centre. No hot drinks facilities within the room though I know this is common in Europe.
The staff on my arrival was extremely welcoming and nice.


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Items in Cart:
Original oil on board by the well known South African Artist WP Grobler whom is internationally renowned. Painting size: 46 x 30cm - unframed. This artist's work is sought after as an investment!
Wonderful Landscape
More original paintings from Pharos Art
Art as an Investment "click" here.
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It puts so much pressure on us to write this post knowing that Bride Krissy is such an excellent blogger/writer, but what the heck, ha ha! Working on this wedding has been so much fun! Would have been more fun though if we did more things for them, but we think it's enough that we were able to pull off the look and feel that Mark & Krissy want for their wedding. Kudos, too, to MyPhotato for capturing it all so perfectly!
Laid-back, relaxed, and fun: that's the order of the day. We're lucky that the weather cooperated, and how! There was enough warm sun to inspire everyone who attended this celebration. We totally love the DIY elements here: the paper medallions the couple made for their backdrop, both for the reception & the ceremony, and the wooden houses that were inspired by the animated film, UP (A++ for the effort!). Everything pretty much channeled the inner child of every guest (oh, to be young and gay!).
At the end of the day, one thing is for sure though: we're going to remember this wedding for a very long time. ^_^
Boutonnieres: We've been working with Craspedia for many years now, but this is the only time that we fused it with non-floral items. In true SoCal tradition, our DIY team, {etc) Handmade Goodness, made leaves out of cotton and gray felt. We also added buttons and used jute twin to put it all together. They turned out to be so pretty & were such a hit!
Mark & Krissy's Wedding from Kel MyPhotato on Vimeo.
Preps: Astoria Plaza
Ceremony: The Mango Farm
Photographer: MyPhotato
Video: MyPhotato
Ceremony Styling: Vatel Manila
Extra DIY Props: Bride Krissy
Boutonnieres: Cecile Roxas-Padecio for {etc} Handmade Goodness
Entourage Flowers: Dylan Gozum for Vatel Manila


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Yesterday was a very chill day for me … so chill that I stayed in my pajamas/sweats all day, all afternoon, all night long … and it was glorious. I spend the afternoon reading before I settled down to watch a couple of movies. I've wanted to see Sinister since it was in theaters last year so I finally got around to it. Then I watched the new documentary film Sound City and, OMG, was I completely blown away. Both movies were entertaining in their own way and provided me with both sweet dreams … and nightmares.
Sinister is one of those horror films where the scares come from tension, things jumping out at you and loud noises … and damnit, does it work. I watched the movie all by myself and literally jumped out of my seat with every noise I happened to hear both in the building and/or outside my open window. Sinister may not be the best horror film ever but it was sufficient to scare the crap out of me last night so … mission: accomplished.
I've heard so many great things about Sound City that I just couldn't wait to see it any longer. Folks, if it is possible to feel love … like, actual affection … for a movie then that is what I felt for this documentary. Sound City is a doc directed by Dave Grohl that tells the amazing story of a recording studio here in SoCal where some of the greatest albums of our time were recorded. If you are a music fan, you must see this film. Man. I'm not kidding. This is a movie that I plan to see again and again … and I will deffo be seeing it soon in an actual movie theater so that I can experience it the way it was meant to be seen. I loved it so much. I know it's early, but Sound City may very well be the best movie of 2013 for me.
Last thing, that cool piece of art pictured above was created by street artist Col. Wallnuts who is based in NYC (see more of his work HERE). As soon as I laid eyes on this piece, I knew I had to have it. Street Art pieces really speak to me and this one was deffo calling my name. I'm happy to have it hanging in my home now. I really wish all y'all could come over to my place and just hang out for a bit … I got some cool stuff to show off :)
Tonight, I'm hitting the road for San Diego where I will be seeing MORRISSEY in concert. Damn, at last … the man is well enough to perform again so away I go. I'm also seeing Moz at the Staples Center on Friday night and then at Hollywood High School on Saturday night where he will be playing an intimately tiny show. I'M SO EXCITED! I was so bummed when he had to cancel that Michigan show I was hoping to see last month but this weekend should MORE than make up for that delay. Happy Hump Day!!0


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Chaparral took just enough points in a tiebreaker Thursday to win at Desert Pines in a boys tennis match.
The teams tied at nine sets each and at three games apiece in the tiebreaker, which Chaparral won on points, 37-36.
D.J. Grassie and Michael Golightly each went 3-0 in singles for Chaparral.
Roberto Caton and Bryan Cabriales went 3-0 in doubles for Desert Pines.
Rancho 12, Moapa Valley 6 — At Rancho, Luis Delgadillo and Mark Chen went 3-0 in singles to lead the Rams over the Pirates.
Valley 11, Las Vegas 7 — At Las Vegas, Jason Lockard and Mitchell Diesko finished 3-0 in doubles to lead the Vikings over the Wildcats.
Brady Page and Brayden Pikyavit went 3-0 in doubles for Las Vegas.
Eldorado 12, Canyon Springs 6 — At Canyon Springs, the Sundevils dominated doubles play and did just enough in singles.
Eldorado's doubles teams of Kaiden Shakespear and James Sernas, Dalton Carpenello and Jacob Martinez, and Alan Guerrera and Nelson Herrera all went 3-0.
Coronado 15, Basic 3 — At Coronado, Adam Gratz and Michael Seitz went 3-0 in doubles to lead the Cougars to a rout of Basic.
Mitchell Smith was 3-0 in singles for Coronado. Xavier Smith went 2-0 in singles for the Cougars.
Del Sol 13, Boulder City 5 — At Boulder City, Anthony Gugino went 3-0 in singles as Del Sol downed the Eagles.
Foothill 15, Liberty 3 — At Foothill, Chris Clementi went 3-0 in singles to lead the Falcons over the Patriots.
Cody Souza and Drew Mortensen went 3-0 in doubles for Foothill.
Silverado 14, Tech 4 — At Silverado, Justin Estell and Todd Vincent went 3-0 in doubles, and Brandon Lombardo went 2-0 in singles to lead the Skyhawks over the Roadrunners.
Bonanza 16, Sierra Vista 2 — At Bonanza, Craig Whiting was 3-0 in singles to help the Bengals beat Sierra Vista.
The doubles teams of Aashish Daulat and John Grady, and Laurent Gontier and Sean Lettero each went 2-0 in doubles.
Durango 16, Western 2 — At Durango, Jeff Leavitt, Matt Leavitt and Marvin Pagayonan each went 2-0 in singles to lead the Trailblazers over the Warriors.
Clark 14, Spring Valley 4 — At Spring Valley, Clark's doubles teams of Dennis Park and Roger Yee, and Jason Gee and Daniel Won finished 2-0 as the Chargers defeated the Grizzlies.
Joe Miceli went 2-0 in singles for Spring Valley.
Bishop Gorman 18, Desert Oasis 0 — At Desert Oasis, Bishop Gorman completed a sweep of the Diamondbacks.
Centennial 15, Cimarron-Memorial 3 — At Centennial, Travis Beck went 3-0 in singles and Austin Howell 2-1 to lead the Bulldogs over the Spartans.
The doubles teams of Kyle Johnson and Tyler Geitzen, Josh Arias and Tyler Rogers, and Patrick Bolton and Brandon Fish each went 2-0 for Centennial.
Cameron Tatz went 2-1 in singles for Cimarron.
Arbor View 17, Cheyenne 1 — At Arbor View, the Aggies were dominant in their victory over the Desert Shields.
Palo Verde 15, Shadow Ridge 3 — At Palo Verde, Brandon Parker, Stan Breland and Fernando Sunago each went 2-0 in singles to lead the Panthers over the Mustangs.
Kamua Jackson and David Nichols teamed to go 2-0 for Palo Verde.
The Meadows-Faith Lutheran match suspended — At Faith Lutheran, the match between The Meadows and Faith Lutheran was suspended with the score tied at 9-9 as the teams didn't have court availability for the tiebreaker.


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The test results were pretty interesting. Unfortunately I wasn't able to run Half-Life 2 on the X1800 XT, since Valve decided to update the code and break all of the demos that everyone uses for benchmarking. However Far Cry threw up some interesting numbers. As expected the X1800 XT was CPU locked at the lower resolutions, much like the 7800 GTX. However, the 7800 GTX was CPU locked at about 20fps above the X1800 XT. The 7800 GTX remained in the lead up to the point where the CPU ceased to be the limiting factor – then the X1800 XT edged ahead. I quizzed ATI about this and was told that the X1800 XT does have a more significant CPU overhead than the 7800 GTX, but it scales better once the CPU is out of the equation.
Looking at both 3DMark 03 and 05, the X1800 XT edged ahead of the 7800 GTX, except in 03, when there was no FSAA or AF enabled. Doom 3 didn't throw up any surprises, with the 7800 GTX well ahead of the X1800 XT, but then nVidia cards have always performed better under OpenGL.
Unlike the X1800 XT, the XL is a single slot solution, but it retains the twin dual-link DVI ports. It's only available in a 256MB configuration, and as mentioned already, the memory runs a full 500MHz slower than the XT! Theoretically you could put an X1800 XL in a small form factor system, although the card is very long and gets extremely hot during heavy use.
Since I was able to take a Radeon X1800 XL back with me, I was able to run a more extensive set of tests, pushing the resolution a bit harder than I was able to on the XT. I compared the X1800 XL directly with a GeForce 7800 GT, since both cards are one step down from the top end.
The 3DMark scores are almost a carbon copy of the XT vs. GTX results – the X1800 XL edges ahead in all the tests bar 3DMark 03 with no image quality settings. I say almost because once I cranked the resolution up to 2,048 x 1,536 the 7800 GT took the lead in all the 3DMark 05 tests.
Further investigation showed that although the X1800 XL appeared to scale better once the CPU limitation was taken out of the equation, once the resolution was pushed up to 2,048 x 1,536, the 7800 GT gained back the ground and often took over.


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List all partitions of an integer
19 Downloads
Updated 16 Jul 2008
The money changing problem is a simple one to state. For example, how many different ways can one form change of a dollar (100 cents) by using only coins of denomination [1 5 10 25 50] ? (The answer is 292.)
Its an example of a general problem, i.e., in how many unique ways can an integer be partitioned as a sum of smaller positive integers?
I wrote partitions to solve the fully general problem, but it can be used with restrictions too. You can constrain the set of elements in the sum, and the maximum number of times any one elements can appear, as well as fixing the total number of terms that will appear in the final sum.
See the demo for a few examples of use.
Flexible script
Thanks a lot, I was looking for this function.
good work
Suppose I wish to list out the integer partitions of 10, using the numbers [1,2,3,4]? The solutions are easy to delineate. Look at the largest element of the candidate members of the partition, in this case, pivot around the number 4. How many times can 4 potentially appear in that sum? Clearly, we may be able to form the total of 10 by including the number 4 a total of 0, 1, or 2 times. If so, then we can reduce the problem.
If 4 appears twice, then we need to find the list of all partitions of 10 - 2*4 = 2, made from the set [1,2,3].
If 4 appears once, then we need to find the list of all partitions of 10 - 1*4 = 6, made from the set [1,2,3].
If 4 appears not at all, then we need to find the list of all partitions of 10 - 0*4 = 10, made from the set [1,2,3].
I can rigorously argue that this procedure must generate all solutions, and do so rather efficiently, to the extent that is possible.
Now, call partitions to solve the problem. See that the last two solutions in the set have 4 appearing twice. There are exactly 2 ways to solve that problem. Before that, we see there were 7 ways to solve the partitions of 6. And there were 14 ways to solve the problem with 4 never appearing at all.
>> partitions(10,1:4)
ans =
10 0 0 0
8 1 0 0
6 2 0 0
4 3 0 0
2 4 0 0
0 5 0 0
7 0 1 0
5 1 1 0
3 2 1 0
1 3 1 0
4 0 2 0
2 1 2 0
0 2 2 0
1 0 3 0
6 0 0 1
4 1 0 1
2 2 0 1
0 3 0 1
3 0 1 1
1 1 1 1
0 0 2 1
2 0 0 2
0 1 0 2
While partitions has other arguments that complicate the problem slightly by constraining the solution, the basic approach is exactly the same. Simply pivot around the largest member of the set of candidates to form that sum. Once you have determined the number of times 4 may appear in the sum, you can forget about it, and then worry about the rest.
Of course, had I tried to solve the problem partitions(500,1:500) by this approach, this would be a rather time (and memory) consuming task. My vpi toolbox has a tool to enumerate the number of integer solutions:
>> numberOfPartitions(500)
ans =
Or, if you prefer...
>> vpi2english(numberOfPartitions(500))
ans =
two sextillion, three hundred quintillion, one hundred sixty five quadrillion, thirty two trillion, five hundred seventy four billion, three hundred twenty three million, nine hundred ninety five thousand, twenty seven
But then, nothing I could do would solve that problem efficiently.
What algorithm is used or what is the theory behind how the partitions are generated by the program.
Thank you John! Its not an easy problem to solve yourself.
Excellent codes with helpful documentation.
Very helpful!
Very good code! Very helpful!
Excellent !!!!
a very useful snippet distinguished by excellent help (including sources of its algorithm), intuitive examples as well as a demo package, exhaustive error checking, good guidance for programmers, and a sleek computational engine.
Version 1.1: Allow the candidate set to be non-decreasing rather than strictly increasing
Inspired by: partitiontable.m
Inspired: nsumk
Download apps, toolboxes, and other File Exchange content using Add-On Explorer in MATLAB.


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Regal Affairs
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text:
kitchen drawer organizer
This is my 1st post on the forum. We have deep kitchen drawers that are set up for vertical storage of pots, lids,trays, etc. Glass partitions separate the various contents. The partitions are slotted into plastic groves in the front & back of the drawers. I believe the plastic material was originally in rolls with adhesive backing. Over time these have deteriorated. I have looked everywhere but cannot find replacements. I would appreciate any help you can offer or for alternative ideas. I've attached a photo to show the material.
Don't see your photo?
I did attach the photo and it was on the message when I reviewed it but failed to end up on the final post.
Here is the URL again:
It does look like some sort of vacuum formed plastic tape. I wonder if dado cuts in some other material like wood would hold up better. Only problem would be I am guessing your glass shelves are cut fairly snug? The would have to be trimmed to accommodate the base of the wood.
I will see what I can find for you. My curiosity is aroused.
kitchen drawer organizer
Thanks for your interest and help. I have thought about routing some thin wood, but have procrastinated and have continued to hope to find the original. If it helps, the original material was applied about 15 years ago with a kitchen remodel.
Bombed out having tried every search string I could think. Router or dado blade may be your best bet? Resulting base thickness vs shelf length will be your challenge. I guess you just need it long enough to place the strip with Gorilla glue or something. Could then chisle voids away?
Many thanks for your help.
Might be able to duplicate that strip(s) in HDPE (plastic cutting board material). The problems there would be fastening it in place, HDPE is a little tricky to glue. I'd probably machine in a couple of bosses to accept screws from the outside of the draw box. Another issue may be that the, I assume tempered, glass dividers may need to be cut a tad shorter depending on how thin you end up with on the ends.:)
Edited to add: It's sorta hard to see, but it looks like the CD storage in this desk.
kitchen drawerorganizer
HMMMMMM. Good idea. I'll check out what's available.
I bought some U shaped, brass channel strips at Home Depot for a similar application. It came with screw holes for mounting purposes. Perhaps you could use something like this.
kitchen drawer organizer
Could you give me a better description of these? Which department were they in?
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Taylors Hill
Households with children
There are 1,360 couples with young children in Taylors Hill in 2011, comprising 39% of households.
Households with Children require different services and facilities than other household types, and their needs change as both adults and children age. When many families in an area are at the same stage in their individual lifecycles, it creates a suburb lifecycle. Knowing where a suburb is in a cycle of change helps planners make evidence-based decisions about the demand for services both now and in the future.
For Households with Children in Taylors Hill, life stage is based on the age of children in the household. The age of the parent(s) is not taken into account.
- Young children: Children aged under 15 only
- Mixed age children: One or more children under 15 and one or more children over 15 (must have 2 or more children)
- Older children: Children aged 15 and over only
To continue building the story, Taylors Hill's Household data should be viewed in conjunction with Household Size, Age Structure and Dwelling Type.
Derived from the Census question:
'What is the person's relationship (to each other person in the household)?'
Source: Australian Bureau of Statistics, Census of Population and Housing (opens a new window) 2006 and 2011. Compiled and presented by .id (opens a new window), the population experts.
(Enumerated data)
Compiled and presented in profile.id by .id, the population experts.
Compiled and presented in profile.id by .id, the population experts.
Dominant groups
Analysis of the families with children in Taylors Hill in 2011 compared to the City of Melton shows that there was a larger proportion of couples with young children, as well as a larger proportion of couples with older children.
Overall, 39.0% of total households with children were couple with young children, and 13.0% were couples with older children, compared with 25.4% and 11.7% respectively for the City of Melton.
There were a smaller proportion of single parent households with young children and a smaller proportion of single parent households with older children. Overall, the proportion of single parent households with young children was 3.6% compared to 5.7% in the City of Melton while the proportion of single parent households with older children was 3.3% compared to 5.2% in the City of Melton.
Emerging groups
Between 2006 and 2011, the number of households with children increased by 1,105 households or 87.1%.
The largest changes in households with children in this area between 2006 and 2011 were:
- Couples with young children (+676 households)
- Couples with older children (+230 households)
- Couples with mixed-age children (+99 households)
- Single parents with older children (+62 households)


text:
January, 2000
This content was archived on June 24 2013.
Information identified as archived on the Web is for reference, research or recordkeeping purposes. It has not been altered or updated after the date of archiving. Web pages that are archived on the Web are not subject to the Government of Canada Web Standards. As per the Communications Policy of the Government of Canada, you can request alternate formats on the "Contact Us" page.
Help on accessing alternative formats, such as PDF, MP3 and WAV files, can be obtained in the alternate format help section.
Health Canada has notified AgrEvo Canada Inc. that it has no objection to the food use of refined oil from canola lines derived from the genetically modified canola line HCN92, which is tolerant to glufosinate ammonium. The Department conducted a comprehensive assessment of canola line HCN92 according to it's Guidelines for the Safety Assessment of Novel Foods (Sept. 1994). These guidelines are based upon internationally accepted principles for establishing the safety of foods derived from genetically modified organisms.
The following provides a summary regarding the AgrEvo Canada Inc. notification to Health Canada and contains no confidential business information.
Canola (Brassica napus L.) line HCN92 was developed through genetic modification to be tolerant to glufosinate ammonium, which is the active ingredient of the herbicide Liberty®. The modification permits farmers to use the broad-spectrum herbicide for weed control in the cultivation of canola without damaging the crop.
The line HCN92 was produced by Agrobacterium-mediated transformation to introduce DNA into a line of B. napus. The introduced DNA is based on the pat gene which was originally isolated from a common soil bacterium, Streptomyces viridochromogenes, and encodes the enzyme, phosphinothricin acetyltransferase (PAT). Also included with the introduced DNA is the nptII gene which encodes resistance to the antibiotic kanamycin. This biological marker allows researchers to identify the modified plants.
Molecular analysis indicated that two copies of the transferred DNA have been incorporated at a single locus in the plant genome. Analysis of segregation data confirms the stable integration of the DNA into the Brassica genome.
The gene products, phosphinothricin acetyl transferase (PAT) and neomycin phosphotransferase (NPTII), the selectable marker, are present in canola tissues at very low levels (< 5 ppm). The PAT protein mediates the rapid metabolism of glufosinate ammonium. Analysis demonstrated that the PAT and NPTII protein or their enzymatic activity could not be detected in the refined oil, the only canola product used for human consumption.
Human consumption of canola products is limited to the refined oil. The processing of refined canola oil destroys the enzymatic activity of the PAT and NPTII protein. As indicated above (Section 3), PAT and NPTII is not detected in the refined oil. As such, no human exposure to the introduced PAT and NPTII protein is expected as a result of the consumption of refined oil from line HCN92.
Compositional analysis of processed canola oil indicated that no statistically significant differences were noted between HCN92 and current commercial canola cultivars for fatty acids, glucosinolates, chlorophyll and phytosterol content. These comparisons indicated no statistically significant differences for the components analysed. The use of refined oil from line HCN92 would therefore have no significant impact on the nutritional quality of the Canadian food supply.
The PAT and NPTII proteins did not show any meaningful amino acid sequence homology when compared to known allergens or protein toxins. Both enzymes have been demonstrated to be highly substrate specific. In addition, they are ubiquitous in nature and do not possess proteolytic or heat stability. No adverse effects have been reported to be associated with either enzyme.
Health Canada's review of the information presented in support of the food use of refined oil from glufosinate ammonium tolerant canola line HCN92 concluded that such refined oil does not raise concerns related to safety. Health Canada is of the opinion that refined oil from canola line HCN92 is as safe and nutritious as refined oil from current commercial varieties.
Health Canada's opinion deals only with the food use of refined oil from the genetically modified canola line HCN92. Issues related to growing canola line HCN92 in Canada and its use as animal feed are addressed separately through existing regulatory processes in the Canadian Food Inspection Agency.
This Novel Food Information document has been prepared to summarize the opinion regarding the subject product provided by the Food Directorate, Health Protection Branch, Health Canada. This opinion is based upon the comprehensive review of information submitted by the petitioner according to the Guidelines for the Safety Assessment of Novel Foods .
For further information, please contact:
Office of Food Biotechnology
Food Directorate
Health Protection Branch
Health Canada
Tunney's Pasture
Ottawa, Ontario K1A 0L2
Telephone: (613) 941-5535
Facsimile: (613) 952-6400


text:
Oregon Historical County Records Guide
Morrow County Scenic Images
Heppner Barn
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An old barn in Heppner. (Photo No. morDA0212)
About this image
Dimensions: 3675 x 2440 pixels (300 dpi version); Date created: September 2007; Camera: Nikon D80 Digital SLR; Lens: Nikon AF-S DX Zoom-Nikkor 18-135mm f/3.5-5.6G IF-ED; Photographer citation: Gary Halvorson, Oregon State Archives; Keywords/Tags: horizontal, Oregon, Morrow County, Heppner, barn, old building, small town, rural, grass, rustic, weathered, blue sky, hill, fence.
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County guide home | Scenic images home


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Rajaram Nagarajan, MD, MS
Clinical Director, Division of Oncology
Clinical Director, Division of Oncology
Associate Professor, UC Department of Pediatrics
Phone 513-636-0670
Fax 513-636-3549
Email email@example.com
Bone tumors; late effects of pediatric cancer therapy
Outcomes following cancer therapy and bone sarcomas
BA: Pre-Medical Sciences, Lehigh University, Bethlehem, PA, 1991.
MD: Medical College of Pennsylvania, Philadelphia, PA, 1995.
Internship and Residency: Pediatrics, Medical College of Virginia, Richmond, VA, 1998.
Fellowship Training: Hematology / Oncology / BMT, University of Minnesota, Minneapolis, MN, 2002.
MS: Clinical Research, University of Minnesota, Minneapolis, MN, 2002.
Certifications: Pediatrics, Pediatric Hematology / Oncology.
View PubMed Publications
Nagarajan R, Kamruzzaman A, Ness KK, Marchese VG, Sklar C, Mertens A, Yasui Y, Robison LL, Marina N. Twenty years of follow-up of survivors of childhood osteosarcoma: a report from the childhood cancer survivor study. Cancer. 2011 Feb 1;117(3):625-34.
Rayburg M, Towbin A, Yin H, Maugans T, Maurer B, Nagarajan R, Weiss B. Langerhans cell histiocytosis in a patient with stage 4 neuroblastoma receiving oral fenretinide. Pediatr Blood Cancer. 2009 Dec;53(6):1111-3.
Nagarajan R. Quality of life (QOL) in patients with osteosarcoma. Recent Results Cancer Res. 2009;179:339-44.
Nagarajan R, Mogil R, Neglia JP, Robison LL, Ness KK. Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS). J Cancer Surviv. 2009 Mar;3(1):59-65.
Zebrack BJ, Zevon MA, Turk N, Nagarajan R, Whitton J, Robison LL, Zeltzer LK. Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the childhood cancer survivor study. Pediatr Blood Cancer. 2007 Jul;49(1):47-51.
Khan K, Schwarzenberg SJ, Sharp H, Jessurun J, Gulbahce HE, Defor T, Nagarajan R. Diagnostic endoscopy in children after hematopoietic stem cell transplantation. Gastrointest Endosc. Sep 2006;64(3):379-85.
Schultz KA, Ness KK, Nagarajan R, Steiner ME. Adnexal masses in infancy and childhood. Clinical Obstetrics and Gynecology. Sep 2006; 49(3):464-79.
Nagarajan R, Clohisy D, Weigel B. New paradigms for therapy for osteosarcoma. Curr Oncol Rep. 2005 Nov;7(6):410-4.
Nagarajan R, Robison LL. Pregnancy outcomes in survivors of childhood cancer. J Natl Cancer Inst Monogr. 2005;(34):72-6.
Spector LG, Ross JA, Nagarajan R. Epidemiology of bone and soft tissue sarcomas. In Pappo A (Ed.) Pediatric Bone and Soft Tissue Tumors. 1st ed. Berlin: Springer-Verlag, 2006.
John P. Perentesis, MD, FAAP
Director, Division of Oncology
Director, Division of Oncology
Institute Co-Director, Cancer and Blood Diseases Institute
Deb Kleisinger Endowed Chair
Professor, UC Department of Pediatrics
Phone 513-636-8241
Email email@example.com
Young adult cancers; acute myeloid & lymphoid leukemia; Hodgkin lymphoma; new anticancer therapy development
Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development
John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute's Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.
In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children's Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.
Dr. Perentesis has been elected by his peers for inclusion in the Best Doctors in America List from 1998 to 2016.
MD: University of Michigan, Ann Arbor, MI, 1980.
Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.
Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.
Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.
Certification: Pediatrics, 1989; Hematology/Oncology, 1990.
Dorris K, Fouladi M, Davies SM, Perentesis JP, Lawrence JM, Chow LM, Assa'ad A, Uygungil B, Jodele S. . Severe Allergic Reactions to Thiol-based Cytoprotective Agents Mesna and Amifostine in a Child With a Supratentorial Primitive Neuroectodermal Tumor. J Pediatr Hematol Oncol. 2011 Jun 3.
Davies SM, Perentesis JP. Tribute: the American Society of Pediatric Hematology/Oncology (ASPHO), 2011 Distinguished Career Award goes to Dr. William G. Woods. Pediatr Blood Cancer. 2011 Jun;56(6):895-6.
Phillips CL, Gerbing R, Alonzo T, Perentesis JP, Harley IT, Meshinchi S, Bhatla D, Radloff G, Davies SM. MDM2 polymorphism increases susceptibility to childhood acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2010 Aug;55(2):248-53.
Wagner LM, Perentesis JP, Reid JM, Ames MM, Safgren SL, Nelson MD Jr, Ingle AM, Blaney SM, Adamson PC. Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with relapsed or refractory solid tumors: a Children's Oncology Group phase I consortium study. Pediatr Blood Cancer. 2010 Apr;54(4):538-45.
Mehta PA, Gerbing RB, Alonzo TA, Elliott JS, Zamzow TA, Combs M, Stover E, Ross JA, Perentesis JP, Meschinchi S, Lange BJ, Davies SM. FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report. Clin Cancer Res. 2008 Dec 1;14(23):7896-9.
Bhatla D, Gerbing RB, Alonzo TA, Conner H, Ross JA, Meshinchi S, Zhai X, Zamzow T, Mehta PA, Geiger H, Perentesis J, Davies SM. Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia. Br J Haematol. 2009 Feb;144(3):388-94.
Geller JI, Wall D, Perentesis J, Blaney SM, Bernstein M; Pediatric Oncology Group study 9376. Phase I study of paclitaxel with standard dose ifosfamide in children with refractory solid tumors: a Pediatric Oncology Group study (POG 9376). Pediatr Blood Cancer. 2009 Mar;52(3):346-50.
Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J, Cripe TP, Lane HA, Kozma SC, Thomas G, Ratner N. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Mol Cancer Ther. 2008 May;7(5):1237-45.
Bhatla D, Gerbing RB, Alonzo TA, Mehta PA, Deal K, Elliott J, Meshinchi S, Geiger H, Perentesis JP, Lange BJ, Davies SM; Children's Oncology Group. DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group. Leukemia. 2008 Feb;22(2):265-72.
Mo J, Lampkin B, Perentesis J, Poole L, Bao L. Translocation (8;18;16)(p11;q21;p13). A new variant of t(8;16)(p11;p13) in acute monoblastic leukemia: case report and review of the literature. Cancer Genet Cytogenet. 2006 Feb;165(1):75-8. Review.
Joseph G. Pressey, MD
Director, Sarcoma Program
Director, Sarcoma Program
Program Leader, Young Adult Oncology Center
Email firstname.lastname@example.com
Musculoskeletal tumors including rhabdomyosarcoma
and other soft-tissue sarcomas; Ewing sarcoma; osteosarcoma; pediatric
solid tumors; rare tumors including small cell carcinoma of the ovary.
The development of novel therapies for pediatric sarcomas and rare tumors.
Dr. Pressey graduated from the University of Georgia and the Medical College of Georgia before pursuing pediatrics residency training at Cincinnati Children's Hospital Medical Center. He trained in pediatric hematology-oncology at the Children's Hospital of Philadelphia where he developed a keen interest in pediatric sarcomas. He spent 11 years at the University of Alabama at Birmingham School of Medicine and Children's Hospital of Alabama where he functioned as the principal investigator (PI) for the Children's Oncology Group (COG) phase 1 and Pilot Consortium and the Sarcoma Alliance for Research through Collaboration (SARC).
Dr. Pressey joined the Cancer and Blood Diseases Institute at Cincinnati Children's to direct the Sarcoma Program. He is appointed clinical associate professor at the University of Cincinnati School of Medicine and functions as the Cincinnati Children's Institutional PI for SARC. Dr. Pressey's research is focused on the development of novel therapies for high-risk and recurrent/refractory solid tumors. Accordingly, he is developing a phase I trial for the COG phase I consortium and bench to bedside investigator initiated trials in collaboration with other investigators nationally.
MD: Medical College of Georgia, Augusta, GA, 1995.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1998.
Fellowship: Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 2001.
Certification: Pediatric Hematology-Oncology, 2002.
Kaylani SZ, Xu J, Srivastava RK, Kopelovich L, Pressey JG, Athar M. Rapamycin Targeting mTOR and Hedgehog Signaling Pathways Blocks Human Rhabdomyosarcoma Growth in Xenograft Murine Model. Biochem Biophys Res Commun. 2013 Jun 14;435(4):557-61.
P, Karnezis AN, Craig DW, Sekulic A, Russell ML, Hendricks WPD,
Corneveaux JJ, Barrett MT, Shumansky K, Yang Y, Shah SP, Prentice LM,
Marra MA, Kiefer J, Zismann VL, McEachron TA, Salhia B, Bodour S, Prat
J, Clarke BA, Pressey JG, Farley JH, Anthony SP, Roden RBS, Cunliffe HE,
Huntsman DG, Trent JM. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations of SMARCA4. Nat Genetics. 2014 May;46(5):427-9.
Pressey JG, Kelly DR, Hawthorne HT. Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type. J Pediatr Hematol Oncol. 2013 Oct;35(7):566-9.
Pressey JG, Haas MC, Pressey CS, Kelly VM, Parker JN, Gillespie GY, Friedman GK. CD133
Marks a Myogenically Primitive Subpopulation in Rhabdomyosarcoma Cell
Lines that are Relatively Chemoresistant but Sensitive to Mutant HSV. Pediatr Blood Cancer. 2013 Jan; 60(1):45-52.
Pressey JG, Anderson JR, Crossman DK, Lynch JC, Barr FG. Hedgehog
Pathway Activity in Pediatric Embryonal Rhabdomyosarcoma and
Undifferentiated Sarcoma: A Report from the Children's Oncology Group. Pediatr Blood Cancer. 2011 Dec 1;57(6):930-8.
Pressey JG, Pressey CS, Kelly DR, Robinson G, Herron R, Wilson L, Kim H. 2D-Difference Gel Electrophoretic Proteomic Analysis of a Cell Culture Model of Alveolar Rhabdomyosarcoma. J Proteome Res. 2011 Feb 4;10(2):624-36.
Xu J, Timares L, Heilpern C, Weng Z, Li C, Xu H, Pressey JG, Elmets C, Kopelovich L, Athar M. Targeting
wild-type and mutant p53 with small molecule CP-31398 blocks the growth
of rhabdomyosarcoma by inducing reactive oxygen species-dependent
apoptosis. Cancer Res. 2010 Aug 15;70(16):6566-76.
Friedman GF, Pressey JG, Reddy AT, Markert JM, Gillespie GY. Herpes Simplex Virus Oncolytic Therapy for Pediatric Malignancies. Mol Ther. 2009 Jul;17(7):1125-35.
Siegel HJ, Pressey JG. Current Concepts in the Surgical and Medical Management of Osteosarcoma. Expert Rev Anticancer Ther. 2008 Aug;8(8):1257-69.
Womer RB, Pressey JG. Rhabdomyosarcoma and soft tissue sarcoma in childhood. Curr Opin Oncol. 2000 Jul ;12: 337-44.
Brian K. Turpin, DO
Member, Division of Oncology
Member, Division of Oncology
Assistant Professor, UC Department of Pediatrics
Phone 513-636-8790
Email firstname.lastname@example.com
Brian K. Turpin, DO, completed his undergraduate training at the University of Missouri, graduate medical training at the Kansas City University of Medicine and Biosciences, and pediatric residency and hematology / oncology fellowship at Cincinnati Children's Hospital Medical Center where he served as co-chief fellow.
Dr. Turpin's clinical and academic interests pertain to children and young adults with solid tumors, particularly sarcomas and neuroblastomas, with a research focus on the development of new drugs and clinical trials for patients with relapsed cancer.
DO: Kansas City University of Medicine and Biosciences.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center.
Fellowship: Pediatric Hematology / Oncology, Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute.
Trout A, Sharp S, Turpin B, Zhang B, Gelfand M. Optimizing the interval between G-CSF therapy and F18 FDG-PET imaging in children and young adult patients receiving chemotherapy for sarcoma. Pediatric Radiology. 2015 Jul;45(7):1001-6.
Andersson C, Kvist PH, McElhinney K, Baylis R, Gram LK, Pelzer H, Lauritzen B, Holm TL, Hogan S, Wu D, Turpin B, Miller W, Palumbo JS. Factor XIII Transglutaminase Supports the Resolution of Mucosal Damage in Experimental Colitis. PLoS One. 2015 Jun 22;10(6):e0128113.
Turpin*, Whitney Miller*, Leah Rosenfeldt, Keith Kombrinck, Matthew J. Flick, Kris A. Steinbrecher, Eleana Harmel-Laws, Eric S. Mullins, Maureen Shaw, David P. Witte, Alexey Revenko, Brett Monia, Joseph S. Palumbo. (* signifies equal contributors). Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res. 2014 Jun 1;74(11):3020-30.
Wagner L, Turpin B, Nagarajan R, Weiss B, Cripe T, Geller J. Pilot Study of Vincristine, Oral Irinotecan, and Temozolomide (VOIT Regimen) Combined with Bevacizumab in Pediatric Patients with Recurrent Solid Tumors or Brain Tumors. Pediatr Blood Cancer. 2013 Apr 29.
Turpin BK, Morris VR, Lemen L, Weiss BD, Gelfand MJ. Minimizing nuclear medicine technologist radiation exposure during 131I-MIBG therapy. Health Phys. 2013 Feb; 104(2 Suppl 1):S43-6.
Trehan I, Turpin BK. Neonatal respiratory distress due to bilateral dacrocystoceles. J Pediatr. 2008 Sep;153(3):438.
Turpin B, Tobias JD. Perioperative management of a child with short-chain acyl-CoA dehydrogenase deficiency. Paediatr Anaesth. 2005 Sep;15(9):771-7.
Cogar BD, Groshong TD, Turpin BK, Guajardo JR. Chylothorax in Henoch-Schonlein purpura: a case report and review of the literature. Pediatr Pulmonol. 2005 Jun;39(6):563-7.
Joel I. Sorger, MD
Co-Director, Sarcoma Program
Co-Director, Sarcoma Program
Director, Pediatric Joint Replacement Surgery
Phone 513-636-4787
Fax 513-636-3928
Email firstname.lastname@example.com
BS: Biology, University of Richmond, VA, August 1983-May 1987.
MD: Medical College of Virginia, Richmond, VA, August 1987-May 1991. Intern: General Surgery Intern, University of Cincinnati, Cincinnati, OH, July 1991-June 1992. Residency: General surgery resident, University of Cincinnati College of Medicine, 1992-1993; Orthopaedic surgery resident, University of Cincinnati College of Medicine, 1994-1998.
Fellowship: Orthopaedic research fellow, Noyes-Giannestras Biomechanics Lab, University of Cincinnati Department of Aerospace Engineering, 1993-1994; Bone and Soft Tissue Sarcoma Management Fellowship (Orthopaedic Oncology), Harvard University, Massachusetts General Hospital and Boston, Children's Hospital, August 1998-July 1999.
Certification: American Board of Orthopaedic Surgeons.
Zbojniewicz AM, Sorger JI. Posttreatment Imaging of Pediatric Musculoskeletal Tumors.
RadioGraphics. 2014 34:724-740.
Wind, M, Swank, M, Sorger J. Short-term Results of a Custom Triflange Acetabular Component for Massive Acetabular Bone Loss in revision THA.
Orthopaedics. 2013 March 36(3):e260-65.
Squires JH, Emery KH, Johnson N, Sorger J. Tibial nerve interneural ganglion cyst in a 10-year old boy.
Pediatr Radiol. Nov 8, 2012.
Mierzwa ML, McCluskey CM, Barrett WL, Lowy A, Sussman J, Sorger J. Interstitial brachytherapy for soft tissue sarcoma: A single institution experience.
Brachytherapy. 2007 Oct-Dec;6(4):298-303.
Mutema GK, Sorger J. Intraosseous Schwannoma of the Humerus. Skeletal Radiol.
2002 Jul;31(7):414-21.
Hornicek FJ, Gebhardt MC, Tomford WW, Sorger JI, Zavatta, M,Menzner Related Articles JP, Mankin HJ. Factors affecting nonunion of the allograft-host junction.
Clin Orthop Relat Res. 2001 Jan;(382):87-98.
Sorger JI, Hornicek FJ, Zavatta M, Menzner JP, Gebhardt MC, Tomford WW, Mankin HJ. Allograft Fractures Revisited.
Clin Orthop Relat Res. 2001 Jan;(382):66-74.
Hornicek FJ, Gebhardt MC, Sorger JI, Mankin HJ. Tumor Reconstruction.
Orthop Clin North Am. 1999 Oct;30(4):673-84.
Sorger, J, Kirk P, Ruhnke C, Bjornson S, Levy M, Cockrin J, Tang P. Once Daily High Dose Versus Divided, Low Dose Gentamicin for Open Fractures.
Clinical Orthopaedic and Related Research. 1999 Sep;(366):197-204.
Sorger J, Kirk P. Failure of an Implant after Total Shoulder Arthroplasty.
Sorger J, Federle D, Kirk P. The Posterior Cruciate Ligament in Total Knee Arthroplasty.
J Arthroplasty.
Stella M. Davies, MBBS, PhD, MRCP
Director, Division of Bone Marrow Transplantation and Immune Deficiency
Director, Division of Bone Marrow Transplantation and Immune Deficiency
Institute Co-Director, Cancer and Blood Diseases Institute
Jacob G. Schmidlapp Endowed Chair
Phone 513-636-1371
Fax 513-803-1969
Email firstname.lastname@example.com
Dr. Davies has been elected by peers for inclusion in the Best Doctors in America List.
MBBS: University of Newcastle-Upon-Tyne, England, 1981.
Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.
PhD: University of Newcastle-Upon-Tyne, England, 1989.
Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.
Mehta PA, Harris RE, Davies SM, Kim MO, Mueller R, Lampkin B, Mo J, Myers K, Smolarek TA. Numerical chromosomal changes and risk of development of myelodysplastic syndrome -- acute myeloid leukemia in patients with Fanconi anemia. Cancer Genet Cytogenet. 2010 Dec;203(2):180-6.
Jodele S, Bleesing JJ, Mehta PA, Filipovich AH, Laskin BL, Goebel J, Pinkard SL, Davies SM. Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2010 Nov 5.
Marsh RA, Vaughn G, Kim MO, Li D, Jodele S, Joshi S, Mehta PA, Davies SM, Jordan MB, Bleesing JJ, Filipovich AH. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. Blood. 2010 Dec 23;116(26):5824-31.Laskin BL, Goebel J, Davies SM, Khoury JC, Bleesing JJ, Mehta PA, Filipovich AH, Paff ZN, Lawrence JM, Yin HJ, Pinkard SL, Jodele S. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant. 2010 Aug 9.Phillips CL, Gerbing R, Alonzo T, Perentesis JP, Harley IT, Meshinchi S, Bhatla D, Radloff G, Davies SM. MDM2 polymorphism increases susceptibility to childhood acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2010 Aug;55(2):248-53.
Mehta PA, Vinks AA, Filipovich A, Bleesing J, Jodele S, Jordan MB, Marsh R, Tarin R, Edwards S, Fearing D, Lawrence J, Davies SM. Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biol Blood Marrow Transplant. 2010 Oct;16(10):1458-62.
Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte / macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61.
Wang D, Zhang W, Kalfa TA, Grabowski G, Davies S, Malik P, Pan D. Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19958-63.
Davies SM, Wang D, Wang T, Arora M, Ringden O, Anasetti C, Pavletic S, Casper J, Macmillan ML, Sanders J, Wall D, Kernan NA. Recent decrease in acute graft-versus-host disease in children with leukemia receiving unrelated donor bone marrow transplants. Biol Blood Marrow Transplant. 2009 Mar;15(3):360-6.
Myers KC, Davies SM. Hematopoietic stem cell transplantation for bone marrow failure syndromes in children. Biol Blood Marrow Transplant. 2009 Mar;15(3):279-92. Review.
Sonata Jodele, MD
Medical Director, Division of Bone Marrow Transplantation and Immune Deficiency
Medical Director, Division of Bone Marrow Transplantation and Immune Deficiency
Phone 513-636-1565
Email firstname.lastname@example.com
MD: Vilnius University School of Medicine, 1988-1994.
Residency: Pediatrics, Downstate HSC at Brooklyn, Brooklyn, NY, 1998-2001.
Fellowship: Pediatric Hematology Oncology, Children's Hospital Los Angeles and Saban Research Institute, Keck School of Medicine University of Southern California, Los Angeles, CA, 2001-2004.
Certifications: Pediatrics, 2001; Pediatric Hematology / Oncology, 2004.
Licenses: California, 2001-present; Ohio, 2004-present.
Jodele S, Zhang K, Zou F, Laskin B, Dandoy CE, Myers KC, Lane A, Meller J, Medvedovic M, Chen J, Davies SM. The genetic fingerprint of susceptibility for transplant associated thrombotic microangiopathy. Blood. 2015 Nov 24.
Jodele S, Fukuda T, Mizuno K, Vinks AA, Laskin BL, Goebel J, Dixon BP, Chima RS, Hirsch R, Teusink A, Lazear D, Lane A, Myers KC, Dandoy CE, Davies SM. Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Feb;22(2):307-15.
Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP. A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev. 2015 May;29(3):191-204.
Jodele S, Davies SM, Lane A, Khoury J, Dandoy C, Goebel J, Myers K, Grimley M, Bleesing J, El-Bietar J, Wallace G, Chima RS, Paff Z, Laskin BL. Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a prospective study in children and young adults. Blood. 2014 Jul 24;124(4):645-53.
Jodele S, S, Fukuda T, Vinks A, Mizuno K, Laskin BL, Goebel J, Dixon BP, Teusink A, Pluthero FG, Lu L, Licht C, Davies SM. Eculizumab Therapy in Children with Severe Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy. Biol Blood Marrow Transplant. 2014 Apr;20(4):518-25.
Jodele S, Licht C, Goebel J, Dixon BP, Zhang K, Sivakumaran TA, Davies SM, Pluthero FG, Lu L, Laskin BL. Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Blood. 2013 Sep 19;122(12):2003-7.
Chima R, Rodney DC, Mi-Ok K, Li D, Wheeler DS, Davies SM, Jodele S. Improved Outcomes for Stem Cell Transplant Recipients Requiring Pediatric Intensive Care. Pediatric Critical Care Medicine. 2012.
Laskin BL, Goebel J, Davies SM, Jodele S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplant associated-thrombotic microangiopathy. Blood. 2011 May 19.
Smith AR, Majhail NS, Macmillan ML, Defor TE, Jodele S, Lehmann LE, Krance R, Davies SM. Hematopoietic cell transplantation comorbidity index predicts transplant outcomes in pediatric patients. Blood. 2011 Jan 12.
Laskin BL, Goebel J, Davies SM, Khoury JC, Bleesing JJ, Mehta PA, Filipovich AH, Paff ZN, Lawrence JM, Yin HJ, Pinkard SL, Jodele S. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant. 2010 Aug 9.
Rachid Drissi, PhD
Member, Division of Oncology
Phone 513-803-0674
Email email@example.com
BS: University of Rouen, France, 1983.
MS: University of Rouen, France, 1984.
MS: University of Paris VI, France, 1988.
PhD: University of Paris VI, France, 1994.
Hummel TR, Salloum R, Drissi R, Kumar S, Sobo M, Goldman S, Pai A, Leach J, Lane A, Pruitt D, Sutton M, Chow LM, Grimme L, Doughman R, Backus L, Miles L, Stevenson C, Fouladi M, DeWire M. A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas.J Neurooncol. 2016 Mar;127(1):53-61.
Hoffman LM, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani A, Brudno M, Kumar SS, Drissi R, Dexheimer P, Salloum R, Chow L, Hummel T, Stevenson C, Lu QR, Jones B, Witte D, Aronow B, Hawkins CE, Fouladi M. Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun. 2016 Jan 4;4(1):1.
Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DT, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M. New brain tumour entities emerge from molecular classification of CNS-PNETs. Cell. 2016 Feb 25;164(5):1060-72.
Margol A, Robison N, Gnanachandran J, Hung LT, Kennedy R, Vali M, Muthugounder S, Dhall G, Finlay JL, Erdreich-Epstein A, Krieger MD, Drissi R, Fouladi M, Gilles FH, Judkins AR, Sposto R, Asgharzadeh S. Tumor Associated Macrophages in SHH Subgroup of Medulloblastomas. Clin Cancer Res. 2014 Oct 24.
Dorris K, Sobo M, Onar-Thomas A, Panditharatna E, Stevenson CB, Gardner SL, DeWire MD, Pierson CR, Rempel SA, Olshefski R, Goldman S, Miles L, Fouladi M, Drissi R*. Prognostic Significance of Telomere Maintenance Mechanisms in Pediatric High-Grade Gliomas. Journal of Neuro-Oncology. 2014 Jan 30. (*senior author)
Thompson PA, Drissi R*, Muscal JA, Panditharatna E, Fouladi M, Ingle AM, Ahern CH, Reid JM, Weigel BJ, Blaney SM. A Phase I Trial of Imetelstat in Children with Refractory or Recurrent Solid Tumors: A Children's Oncology Group Phase 1 Consortium Study (ADVL1112). Clin Cancer Res. 2013 Oct 4. (*biology chair)
Sturm D, Witt H, Hovestadt V, Quang DK, Jones DTW, Konermann C, Pfaff E, Sill M, Bender S, Kool M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Rizhova M, Tönjes M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald M, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Milde T, Witt O, Lindroth A, Schwartzentruber J, Faury D, Zakrzewska M, Zakrzewski K, Liberski PP, Zapatka M, Hauser P, Garami M, Klekner A, Bognar L, van Sluis P, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM. Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of glioblastoma. Cancer Cell. 2012;22:425-437.
Drissi R*, Bockhold CA, Wu J, Dome JS*. Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human Cells. Cancer Prev Res. 2011;4(12):1973-1981. (*joint senior author)
Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Shwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambroock PJ, Andreassen PR, Wiesmüller L, Wells SI. The human DEK oncogene regulates DNA damage response signaling and repair. Nucleic Acids Res. 2011;39(17):7465-7476.
Sanders RP, Drissi R, Billups CA, Daw NC, Valentine MB, Dome JS. Telomerase expression predicts unfavorable outcome in osteosarcoma. J Clin Oncol. 2004 Sep 15;22(18):3790-7.
Joseph S. Palumbo, MD
Director, Comprehensive Thrombophilia Center
Director, Comprehensive Thrombophilia Center
Fax 513-803-5095
Email email@example.com
Dr. Palumbo has been elected by peers for inclusion in the Best Doctors in America List.
MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.
Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.
Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.
Subspecialty: Pediatric Hematology / Oncology.
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 2011 Jul 25.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011 Jun 9;117(23):6326-37.
Akunuru S, Palumbo J, Zhai QJ, Zheng Y. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PLoS One. 2011 Feb 9;6(2):e16951.
Palumbo JS, Degen JL. Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res. 2010 Apr;125 Suppl 2:S39-43. Review.
Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS. Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen. Cancer Res. 2010 Apr 1;70(7):2634-43.
Palumbo JS. Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination. Semin Thromb Hemost. 2008 Mar;34(2):154-60. Review.
Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008 May;6(5):812-9.
Palumbo JS, Degen JL. Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis. Thromb Res. 2007;120 Suppl 2:S22-8.
Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007 Nov;117(11):3224-35.
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood. 2007 Jul 1;110(1):133-41.
Dao Pan, PhD
Member, Division of Experimental Hematology & Cancer Biology
Member, Division of Experimental Hematology & Cancer Biology
Phone 513-636-6315
Fax 513-636-1330
Email email@example.com
Hematopoietic stem cells; mesenchymal stem/progenitor cells; gene therapy; human genetics; translational research; lysosomal storage diseases
Visit the Pan Lab.
BS: Peking Normal University, Beijing, China, 1988.
MS: Peking Normal University, Beijing, China, 1991.
PhD: University of Minnesota, Minneapolis, MN, 1997.
Wang X, Chiang A, Shin SC, Chen L, Pan D, Rawlings DJ, Miao CH. Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine Hemophilia A. Mol Ther. 2015 Feb 6;23(4):617-26.
El-Amouri SS, Dai D, Han JF, Brady RO, Pan D. Normalization and improvement of CNS deficits of mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted Iduronidase. Mol Ther. 2014;22(12):2028-37.
Dai M, Han J, El-Amouri SS, Brady RO, Pan D. Platelets are efficient and protective depots for storage, distribution and delivery of lysosomal enzyme in mice with Hurler Syndrome. Proc Natl Acad Sci USA. 2014;111:2680-2685.
Wang D, El-Amouri SS, Dai M, Kuan A, Hui D, Brady RO, Pan D. Engineering a lysosomal enzyme with receptor-binding domain of ApoE enables delivery across the blood-brain barrier. Proc Natl Acad Sci U S A. 2013;110:2999-3004.
El-Amouri SS, Cao P, Miao CH, Pan D. Secreted luciferase for in vivo evaluation of systemic protein delivery in mice. Mol Biotech. 2013;53:63-73.
Pan D*, Kalfa TA, Wang D, Risinger M, Crable S, Ottlinger A, Mount DB, Hubner CA, Franco RS, Joiner CH*. KCl cotransporter gene expression during human and murine erythroid differentiation. J Biol Chem. 2011;286(35): 30492-30503. *co-correspondent authors.
Wang D, Zhang W, Kalfa TA, Grabowski G, Davies S, Malik P, Pan D. Reprogramming Erythroid Cells for Lysosomal Enzyme Production Leads to Visceral and CNS Cross-correction in Mice with Hurler Syndrome. Proc Natl Acad Sci U S A. 2009;106:19958-63.
Worsham N, Scheusler T, von Kalle C, Pan D. In vivo gene transfer into adult stem cells in non-conditioned mice by in situ delivery of a lentiviral vector. Mol Ther. 2006;14(4): 514-524.
Nancy Ratner, PhD
Co-Director, Rasopathy Program
Co-Director, Rasopathy Program
Program Leader, Cancer Biology and Neural Tumors Program
Beatrice C. Lampkin Chair, Cancer Biology
Phone 513-636-9469
Email email@example.com
Preclinical testing in neurofibromatosis tumors
Genetic mutations in tumor suppressor genes; development of the nervous system; peripheral nerve tumor formation
Visit the Ratner Lab.
Nancy Ratner, PhD, is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR and MEK as potential therapeutic targets in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST.
Dr. Ratner received her bachelor's from Brown University, her doctorate from Indiana University, and was a postdoctoral fellow at Washington University in St. Louis. She was a member of the faculty at the University of Cincinnati from 1987 to 2004. Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Diseases Institute where she holds the Beatrice C. Lampkin Endowed chair in cancer biology and serves as PI of the NINDS P50 "Cincinnati Center in NF Research."
Dr. Ratner is an active member of the International Consortium on the Molecular Biology of NF1, NF2, and Schwannomatosis and was a member of the advisory board for the National Neurofibromatosis Foundation (now Children's Tumor Foundation) from 1989 to 2007. She chaired the Department of Defense Neurofibromatosis Research Program Integration Panel in 2008, and currently serves as a member of the James McDonnell Brain Tumor Research Advisory Board. She received the von Recklinghausen Award from the Children's Tumor Foundation in 2010 and the Jacob K. Javits Neuroscience Investigator Award (NIH-NINDS MERIT Award) in 2014.
PhD: Indiana University, 1982.
BA: Brown University, 1975.
Fellowship: Washington University St. Louis, 1982-1987.
Mayes DA, Rizvi TA, Titus-Mitchell HA, Oberst R, Ciraolo GM, Vorhees CV, Robinson AP, Miller SD, Stemmer-Rachamimov AO, Ratner N. Nf1 loss and Ras activation in Oligodendrocytes induce NOS-driven Defects in Myelin and Vasculature. Cell Reports. 2013 Sep 26;4(6):1197-212.
Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity B, Beckmann DA, Wolf N, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra S, Ratner N, Largaespada DA. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies novel genes and genetic pathways driving tumorigenesis. Nature Genetics. 2013;45(7):756-66.
Watson AL, Rahrmann EP, Moriarity B, Choi K, Conboy C, Greeley A, Halfond A, Anderson L, Wahl B, Keng VW, Rizzardi A, Forser C, Collins MH, Sarver A, Wallace M, Schmechel S, Ratner N, Largaespada DA. Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance. Cancer Discov. 2013 Jun;3(6):674-689.
Prada CE, Jousma E, Rizvi TA, Wu J, Dunn RS, Mayes DA, Cancelas JA, Dombi E, West BL, Bollag G, Ratner N. Neurofibroma associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta Neurpathol. 2013;125(1):159-68.
Jessen WJ, Miller SJ, Jousma E, Rizvi TA, Eaves D, Wu J, Widemann B, Kim M-O, Dombi E, Dudley AH, Niwa-Kawakita M, Page GP, Giovannini M, Aronow BJ, Cripe TP, Ratner N. MEK Inhibition Exhibits Efficacy in Human and Mouse Neurofibromatosis Tumors Despite Transcriptional Feedback onto ERK. J Clin. Invest. 2013 Jan 2;123(1):340-7.
Patel AV, Eaves D, Jessen WJ, Rizvi TA, Ecsedy JA, Qian MG, Aronow BJ, Perentesis JP, Serra E, Cripe TP, Miller SJ, Ratner N. Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target. Clin Canc Res. 2012 Sep 15;18(18):5020-30.
Hennigan RF, Moon CO, Parysek LM, Monk KR, Morfini G, Berth S, Brady ST, Ratner N. Merlin Modulates Microtubule-Based Vesicle Trafficking via Rac, MLK and p38SAPK. Oncogene. 2012;29(3):368-79.
Mayes DA, Rizvi TA, Cancelas JA, Kolasinski NT, Ciraolo GM, Stemmer-Rachamimov AO, Ratner N. Perinatal or Adult Nf1 Inactivation Using Tamoxifen-Inducible PlpCre Each Cause Neurofibroma Formation. Cancer Res. 2011 Jul 1;71(13):4675-85.
Hummel TR, Jessen WJ, Miller SC, Kluwe L, Mautner VF, Wallace MR, Lázaro C, Page G, Worley P, Aronow BJ, Schorry E, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clin Cancer Res. 2010;16 5048-57.
Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S, Jegga A, Li H, Upadhyaya M, Giovannini M, Muir D, Wallace MR, Lopez E, Serra E, Lazaro C, Stemmer-Rachamimov A, Page G, Aronow BJ, Ratner N. Integrative genomic analyses of neurofibromatosis tumors identify SOX9 as biomarker and survival gene. EMBO Mol Medicine. 2009 1(4): 236-48.
Mitogenic Activities in Neurofibromatosis. Principal Investigator. Sept 2011-2016. NIH-R01 NS 28840-20.
Preclinical Testing: GEM-Neurofibroma. Principal Investigator. Children's Tumor Foundation. Aug 2013-Jul 2016.
Identification of Neurofibroma Growth and Drug Resistance Pathways. Principal Investigator. Neurofibromatosis Therapeutic Acceleration Program (NTAP). Apr 2014-Mar 2016.
Ras Proteins in Nerve Tumorigenesis. Principal Investigator. Apr 2014-Mar 2019. 1R01 NS083580-01A1.
Novel Combinatorial Therapies for Malignant Peripheral Nerve Sheath Tumors. Co-Principal Investigator. Jul 2014-Jun 2016. 1R21NS084885-01A1.
Disordered Wnt/b-catenin signaling in MPNST Development and Maintenance. Co-Principal Investigator. Oct 2014-Sep 2019. 1R01NS086219-01A1.
Can targeted therapy prevent neurofibroma growth in mice? Principal Investigator. Neurofibromatosis Therapeutic Acceleration Program (NTAP). Sep 2014-Aug 2016.
Susanne Wells, PhD
Director, Epithelial Carcinogenesis and Stem Cell Program
Director, Epithelial Carcinogenesis and Stem Cell Program
Phone 513-636-5986
Email firstname.lastname@example.com
Squamous cell carcinoma; mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer; role of specific cellular HPV targets in viral replication and cellular transformation
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Bahassi M, Li YQ, Wise-Draper TM, Deng L, Wang J, Darnell CN, Wilson KM, Wells SI, Stambrook PJ. Rixe O. A patient-derived somatic mutation in the epidural growth factor ligand-binding domain confers increased sensitivity to cetuximab in heck and neck cancer. European J Cancer. 2013 Jul:49(10):2345-55.
Privette Vinnedge LM, Ho SM. Wikenheiser-Brokamp KA, Wells SI. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS One. 2012;7(10):e46985.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI. The Fanconi anemia pathway limits human papillomavirus replication. J Virol. 2012 Aug;86(15);8131-8.
Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI, Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012 Sep;160(3):167-77.
Morrison MA, Morreale RJ, Akunuru S, Kofron M, Zheng Y, Wells SI. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the BPV1 E2 protein stimulates cellular motility. J Virol. 2011 Oct;85(20):10487-98.
Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, Harris RE, Filipovich AH, Kovacic MB, Wells SI, Mehta PA. Impaired immune function in children with Fanconi anaemia. Br J Haematol. 2011 Jul;154(2):234-40.
Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmuller L, Wells SI. The human DEK oncogene regulates DNA damage response signaling and repair. Nucl Acids Res. 2011 Sep 1;39(17):7465-76.
Privette Vinnedge LM, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE, Wells SI. The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene. 2011 Jun 16;30:2741-52.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Toile K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011 Feb 3;470(733):105-9.
Meyer SE, Peace BE, Bahassi el M, Kavanaugh GM, Wagh PK, Robbins SB, Yin M,Wells SI, Zinser GM, Stambrook PJ, Waltz SE. Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice. Cancer Lett. 2010 Oct 28;296(2):186-93.
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Halston Heritage
Color-block georgette gown
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Halston Heritage
Color-block georgette gown
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- - Fits true to size, take your normal size
- - Cut for a loose fit
- - Mid-weight, non-stretchy fabric
- - Model is 177cm/ 5'10" and is wearing a size XSmall
Halston Heritage's clever use of color emphasizes the billowy silhouette of this georgette gown. Adjust the shoulder straps to achieve your ideal fit and keep the drapery in focus with minimal accessories.
Shown here with: Bottega Veneta Clutch, Gianvito Rossi Sandals, Ben-Amun Bracelet, Ben-Amun Bracelet, Hervé Van der Straeten Ring, Arme De L'Amour Ring.
- - Black, chartreuse and white georgette
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- - 100% polyester
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What is in this article?:
- Whether You are Talking Lean or Continuous Improvement, Problems are a Gold Mine
- Workforce Brings Issues Forward
You don't want problems. You want a plant floor or an office or a business process that runs like a well-oiled machine all the time -- in fact you want it to run like a perfectly oiled machine.
That is never going to happen, human nature, equipment and life being what they are. The next best thing, then, is to have an organization fully populated with problem solvers -- better known as a continuous-improvement culture.
"The most powerful thing is to utilize all of your employees as problem solvers and not rely on your one Six Sigma expert or your six lean experts," says Bill Willick, director of lean enterprise at Greatbatch Inc. "The key is to change your culture into a continuous-improvement culture where you're leveraging [everyone] as continuous improvement experts."
Willick leads the lean enterprise center of excellence at Greatbatch Inc., a manufacturer primarily of components for medical devices. During a recent interview with IndustryWeek, he shared some of his philosophies regarding lean and continuous improvement. To begin with, he generally prefers speaking of "continuous improvement" rather than "lean." Lean tools, Six Sigma and general problem solving is what you want to teach the workforce, he explains.
Problems are Good Things
Bill Willick
Willick tells the story of being on the receiving end of some wise advice: No problem is a problem. "If you have no problems, then either you don't see that you have problems or you're hiding problems," Willick says. "Problems are a gold mine. They are our opportunity to get better."
In fact, the director of lean enterprise says a sign that shows you are developing a continuous-improvement culture is when employees are excited about sharing the fact they have a problem, rather than being embarrassed about it. That means not only are they recognizing that "identifying problems is a good thing, not a bad thing," Willick explains, but they also know that public chastisement (or something equally negative) isn't the reward for sharing the problem.
Willick has seen the evolution at his own company. Helping to drive improvement is, obviously, one of the goals of the lean enterprise center of excellence. Early on, however, identifying areas or processes that required help typically came from him or his team having their "antennae up" and seeing issues. Alternatively, an executive leadership team member may have noticed challenges in a certain area and pointed them out.
Where the request for assistance typically didn't come from, however, was the person or process requiring help. That has changed.