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Serevent Diskus
US Asthma Prevalence Plateauing, but Not Among the Poor »
"Rates of asthma prevalence in the United States are leveling off and possibly declining, but not among the poor, according to a study published online December 28 in Pediatrics.
Overall prevalence of childhood asthma doubled fr"...
Read the US Asthma Prevalence Plateauing, but Not Among the Poor article »
Serevent Diskus
Asthma-Related Death
LABA, such as salmeterol, the active ingredient in SEREVENT DISKUS, increase the risk of asthma-related death. Currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control drugs mitigates the increased risk of asthma-related death from LABA.
Because of this risk, use of SEREVENT DISKUS for the treatment of asthma without concomitant use of a long-term asthma control medication, such as an inhaled corticosteroid, is contraindicated. Use SEREVENT DISKUS only as additional therapy for patients with asthma who are currently taking but are inadequately controlled on a longterm asthma control medication, such as an inhaled corticosteroid. Once asthma control is achieved and maintained, assess the patient at regular intervals and step down therapy (e.g., discontinue SEREVENT DISKUS) if possible without loss of asthma control and maintain the patient on a long-term asthma control medication, such as an inhaled corticosteroid. Do not use SEREVENT DISKUS for patients whose asthma is adequately controlled on low- or medium-dose inhaled corticosteroids.
Pediatric and Adolescent Patients
Available data from controlled clinical trials suggest that LABA increase the risk of asthma-related hospitalization in pediatric and adolescent patients. For pediatric and adolescent patients with asthma who require addition of a LABA to an inhaled corticosteroid, a fixed-dose combination product containing both an inhaled corticosteroid and a LABA should ordinarily be used to ensure adherence with both drugs. In cases where use of a separate long-term asthma control medication (e.g., inhaled corticosteroid) and a LABA is clinically indicated, appropriate steps must be taken to ensure adherence with both treatment components. If adherence cannot be assured, a fixed-dose combination product containing both an inhaled corticosteroid and a LABA is recommended.
The Salmeterol Multi-center Asthma Research Trial (SMART) was a large 28-week placebo-controlled US trial comparing the safety of salmeterol (SEREVENT Inhalation Aerosol) with placebo, each added to usual asthma therapy, that showed an increase in asthma-related deaths in subjects receiving salmeterol [see Clinical Studies]. Given the similar basic mechanisms of action of beta2-agonists, the findings seen in the SMART trial are considered a class effect.
A 16-week clinical trial performed in the United Kingdom, the Salmeterol Nationwide Surveillance (SNS) trial, showed results similar to the SMART trial. In the SNS trial, the rate of asthma-related death was numerically, though not statistically significantly, greater in subjects with asthma treated with salmeterol (42 mcg twice daily) than those treated with albuterol (180 mcg 4 times daily) added to usual asthma therapy.
The SNS and SMART trials enrolled subjects with asthma. No trials have been conducted that were primarily designed to determine whether the rate of death in patients with COPD is increased by LABA.
Deterioration Of Disease And Acute Episodes
SEREVENT DISKUS should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. SEREVENT DISKUS has not been studied in subjects with acutely deteriorating asthma or COPD. The initiation of SEREVENT DISKUS in this setting is not appropriate.
Serious acute respiratory events, including fatalities, have been reported when salmeterol has been initiated in patients with significantly worsening or acutely deteriorating asthma. In most cases, these have occurred in patients with severe asthma (e.g., patients with a history of corticosteroid dependence, low pulmonary function, intubation, mechanical ventilation, frequent hospitalizations, previous life-threatening acute asthma exacerbations) and in some patients with acutely deteriorating asthma (e.g., patients with significantly increasing symptoms; increasing need for inhaled, short-acting beta2-agonists; decreasing response to usual medications; increasing need for systemic corticosteroids; recent emergency room visits; deteriorating lung function). However, these events have occurred in a few patients with less severe asthma as well.
It was not possible from these reports to determine whether salmeterol contributed to these events.
Increasing use of inhaled, short-acting beta2-agonists is a marker of deteriorating asthma. In this situation, the patient requires immediate reevaluation with reassessment of the treatment regimen, giving special consideration to the possible need for adding additional inhaled corticosteroid or initiating systemic corticosteroids. Patients should not use more than 1 inhalation twice daily of SEREVENT DISKUS.
SEREVENT DISKUS should not be used for the relief of acute symptoms, i.e., as rescue therapy for the treatment of acute episodes of bronchospasm. An inhaled, short-acting beta2- agonist, not SEREVENT DISKUS, should be used to relieve acute symptoms such as shortness of breath. When prescribing SEREVENT DISKUS, the healthcare provider should also prescribe an inhaled, short-acting beta2-agonist (e.g., albuterol) for treatment of acute symptoms.
When beginning treatment with SEREVENT DISKUS, patients who have been taking oral or inhaled, short-acting beta2-agonists on a regular basis (e.g., 4 times a day) should be instructed to discontinue the regular use of these drugs.
SEREVENT DISKUS Is Not A Substitute For Corticosteroids
There are no data demonstrating that SEREVENT DISKUS has a clinical anti-inflammatory effect such as that associated with corticosteroids. When initiating and throughout treatment with SEREVENT DISKUS in patients receiving oral or inhaled corticosteroids for treatment of asthma, patients must continue taking a suitable dosage of corticosteroids to maintain clinical stability even if they feel better as a result of initiating SEREVENT DISKUS. Any change in corticosteroid dosage should be made ONLY after clinical evaluation.
Excessive Use Of SEREVENT DISKUS And Use With Other Long-Acting Beta2-Agonists
SEREVENT DISKUS should not be used more often than recommended, at higher doses than recommended, or in conjunction with other medicines containing LABA, as an overdose may result. Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. Patients using SEREVENT DISKUS should not use another medicine containing a LABA (e.g., formoterol fumarate, arformoterol tartrate, indacaterol) for any reason.
Paradoxical Bronchospasm And Upper Airway Symptoms
As with other inhaled medicines, SEREVENT DISKUS can produce paradoxical bronchospasm, which may be life threatening. If paradoxical bronchospasm occurs following dosing with SEREVENT DISKUS, it should be treated immediately with an inhaled, short-acting bronchodilator. SEREVENT DISKUS should be discontinued immediately, and alternative therapy should be instituted. Upper airway symptoms of laryngeal spasm, irritation, or swelling, such as stridor and choking, have been reported in patients receiving SEREVENT DISKUS.
Cardiovascular And Central Nervous System Effects
Excessive beta-adrenergic stimulation has been associated with seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, palpitation, nausea, dizziness, fatigue, malaise, and insomnia [see OVERDOSAGE]. Therefore, SEREVENT DISKUS, like all products containing sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.
Salmeterol can produce a clinically significant cardiovascular effect in some patients as measured by pulse rate, blood pressure, and/or symptoms. Although such effects are uncommon after administration of salmeterol at recommended doses, if they occur, the drug may need to be discontinued. In addition, beta-agonists have been reported to produce electrocardiogram (ECG) changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The clinical significance of these findings is unknown. Large doses of inhaled or oral salmeterol (12 to 20 times the recommended dose) have been associated with clinically significant prolongation of the QTc interval, which has the potential for producing ventricular arrhythmias. Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs.
Immediate Hypersensitivity Reactions
Immediate hypersensitivity reactions (e.g., urticaria, angioedema, rash, bronchospasm, hypotension), including anaphylaxis, may occur after administration of SEREVENT DISKUS. There have been reports of anaphylactic reactions in patients with severe milk protein allergy after inhalation of powder products containing lactose; therefore, patients with severe milk protein allergy should not take SEREVENT DISKUS [see CONTRAINDICATIONS]
Drug Interactions With Strong Cytochrome P450 3A4 Inhibitors
The use of strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with SEREVENT DISKUS is not recommended because increased cardiovascular adverse effects may occur [see DRUG INTERACTIONS, CLINICAL PHARMACOLOGY].
Coexisting Conditions
SEREVENT DISKUS, like all medicines containing sympathomimetic amines, should be used with caution in patients with convulsive disorders or thyrotoxicosis and in those who are unusually responsive to sympathomimetic amines. Doses of the related beta2-adrenoceptor agonist albuterol, when administered intravenously, have been reported to aggravate preexisting diabetes mellitus and ketoacidosis.
Hypokalemia And Hyperglycemia
Beta-adrenergic agonist medicines may produce significant hypokalemia in some patients, possibly through intracellular shunting, which has the potential to produce adverse cardiovascular effects [see CLINICAL PHARMACOLOGY]. The decrease in serum potassium is usually transient, not requiring supplementation. Clinically significant and dose-related changes in blood glucose and/or serum potassium were seen infrequently during clinical trials with SEREVENT DISKUS at recommended doses.
Patient Counseling Information
Advise the patient to read the FDA-approved patient labeling (Medication Guide and Instructions for Use).
Asthma-Related Death
Inform patients that salmeterol increases the risk of asthma-related death and may increase the risk of asthma-related hospitalization in pediatric and adolescent patients. Inform patients that SEREVENT DISKUS should not be the only therapy for the treatment of asthma and must only be used as additional therapy when long-term asthma control medications (e.g., inhaled corticosteroids) do not adequately control asthma symptoms. Also inform them that currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other longterm asthma control drugs mitigates the increased risk of asthma-related death from LABA. Inform patients that when SEREVENT DISKUS is added to their treatment regimen they must continue to use their long-term asthma control medication.
Not for Acute Symptoms
Inform patients that SEREVENT DISKUS is not meant to relieve acute asthma symptoms or exacerbations of COPD and extra doses should not be used for that purpose. Advise patients to treat acute symptoms with an inhaled, short-acting beta2-agonist such as albuterol. Provide patients with such medication and instruct them in how it should be used.
Instruct patients to seek medical attention immediately if they experience any of the following:
- Decreasing effectiveness of inhaled, short-acting beta2-agonists
- Need for more inhalations than usual of inhaled, short-acting beta2-agonists
- Significant decrease in lung function as outlined by the physician
Tell patients they should not stop therapy with SEREVENT DISKUS without physician/provider guidance since symptoms may recur after discontinuation.
Not a Substitute for Corticosteroids
Advise all patients with asthma that they must also continue regular maintenance treatment with an inhaled corticosteroid if they are taking SEREVENT DISKUS.
SEREVENT DISKUS should not be used as a substitute for oral or inhaled corticosteroids. The dosage of these medications should not be changed and they should not be stopped without consulting the physician, even if the patient feels better after initiating treatment with SEREVENT DISKUS.
Do Not Use Additional Long-Acting Beta2-Agonists
Instruct patients not to use other LABA.
Immediate Hypersensitivity Reactions
Advise patients that immediate hypersensitivity reactions (e.g., urticaria, angioedema, rash, bronchospasm, hypotension), including anaphylaxis, may occur after administration of SEREVENT DISKUS. Patients should discontinue SEREVENT DISKUS if such reactions occur. There have been reports of anaphylactic reactions in patients with severe milk protein allergy after inhalation of powder products containing lactose; therefore, patients with severe milk protein allergy should not take SEREVENT DISKUS.
Risks Associated With Beta-Agonist Therapy
Inform patients of adverse effects associated with beta2-agonists, such as palpitations, chest pain, rapid heart rate, tremor, or nervousness.
Treatment of Exercise-Induced Bronchospasm
Patients using SEREVENT DISKUS for the treatment of EIB should not use additional doses for 12 hours. Patients who are receiving SEREVENT DISKUS twice daily should not use additional SEREVENT for prevention of EIB.
Nonclinical Toxicology
Carcinogenesis, Mutagenesis, Impairment Of Fertility
In an 18-month carcinogenicity study in CD-mice, salmeterol at oral doses of 1.4 mg/kg and above (approximately 20 times the MRHDID for adults and children based on comparison of the plasma AUCs) caused a dose-related increase in the incidence of smooth muscle hyperplasia, cystic glandular hyperplasia, leiomyomas of the uterus, and ovarian cysts. No tumors were seen at 0.2 mg/kg (approximately 3 times the MRHDID for adults and children based on comparison of the AUCs).
In a 24-month oral and inhalation carcinogenicity study in Sprague Dawley rats, salmeterol caused a dose-related increase in the incidence of mesovarian leiomyomas and ovarian cysts at doses of 0.68 mg/kg and above (approximately 55 and 25 times the MRHDID for adults and children, respectively, on a mg/m basis). No tumors were seen at 0.21 mg/kg (approximately 15 and 8 times the MRHDID for adults and children, respectively, on a mg/m basis). These findings in rodents are similar to those reported previously for other betaadrenergic agonist drugs. The relevance of these findings to human use is unknown.
Salmeterol produced no detectable or reproducible increases in microbial and mammalian gene mutation in vitro. No clastogenic activity occurred in vitro in human lymphocytes or in vivo in a rat micronucleus test. No effects on fertility were identified in rats treated with salmeterol at oral doses up to 2 mg/kg (approximately 160 times the MRHDID for adults on a mg/m basis).
Use In Specific Populations
Teratogenic Effects
Pregnancy Category C. There are no adequate and well-controlled trials with SEREVENT DISKUS in pregnant women. Beta2-agonists have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Because animal reproductive studies are not always predictive of human response, SEREVENT DISKUS should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Women should be advised to contact their physicians if they become pregnant while taking SEREVENT DISKUS.
No teratogenic effects occurred in rats at salmeterol doses approximately 160 times the maximum recommended daily inhalation dose (MRHDID) (on a mg/m² basis at maternal oral doses up to 2 mg/kg/day). In pregnant Dutch rabbits administered oral doses approximately 50 times the MRHDID (on an AUC basis at maternal oral doses of 1 mg/kg/day and higher), fetal toxic effects were observed characteristically resulting from beta-adrenoceptor stimulation. These included precocious eyelid openings, cleft palate, sternebral fusion, limb and paw flexures, and delayed ossification of the frontal cranial bones. No such effects occurred at a salmeterol dose approximately 20 times the MRHDID (on an AUC basis at a maternal oral dose of 0.6 mg/kg/day).
New Zealand White rabbits were less sensitive since only delayed ossification of the frontal cranial bones was seen at an oral dose approximately 1,600 times the MRHDID (on a mg/m basis at a maternal oral dose of 10 mg/kg/day).
Salmeterol crossed the placenta following oral administration to mice and rats.
Labor And Delivery
There are no well-controlled human trials that have investigated effects of salmeterol on preterm labor or labor at term. Because of the potential for beta-agonist interference with uterine contractility, use of SEREVENT DISKUS during labor should be restricted to those patients in whom the benefits clearly outweigh the risks.
Nursing Mothers
Plasma levels of salmeterol after inhaled therapeutic doses are very low. In rats, salmeterol xinafoate is excreted in the milk. Since there are no data from controlled trials on the use of SEREVENT DISKUS by nursing mothers, caution should be exercised when SEREVENT DISKUS is administered to a nursing woman.
Pediatric Use
Available data from controlled clinical trials suggest that LABA increase the risk of asthma-related hospitalization in pediatric and adolescent patients. For pediatric and adolescent patients with asthma who require addition of a LABA to an inhaled corticosteroid, a fixed-dose combination product containing both an inhaled corticosteroid and a LABA should ordinarily be used to ensure adherence with both drugs [see INDICATIONS AND USAGE, WARNINGS AND PRECAUTIONS].
The safety and efficacy of SEREVENT DISKUS in adolescents (aged 12 years and older) have been established based on adequate and well-controlled trials conducted in adults and adolescents [see Clinical Studies]. A large 28-week placebo-controlled US trial comparing salmeterol (SEREVENT Inhalation Aerosol) and placebo, each added to usual asthma therapy, showed an increase in asthma-related deaths in patients receiving salmeterol [see Clinical Studies]. Post-hoc analyses in pediatric patients aged 12 to 18 years were also performed. Pediatric patients accounted for approximately 12% of patients in each treatment arm. Respiratory-related death or life-threatening experience occurred at a similar rate in the salmeterol group (0.12% [2/1,653]) and the placebo group (0.12% [2/1,622]; relative risk: 1.0 [95% CI: 0.1, 7.2]). All-cause hospitalization, however, was increased in the salmeterol group (2% [35/1,653]) versus the placebo group (less than 1% [16/1,622]; relative risk: 2.1 [95% CI: 1.1, 3.7]).
The safety and efficacy of SEREVENT DISKUS have been evaluated in over 2,500 patients aged 4 to 11 years with asthma, 346 of whom were administered SEREVENT DISKUS for 1 year. Based on available data, no adjustment of dosage of SEREVENT DISKUS in pediatric patients is warranted for either asthma or EIB.
In 2 randomized, double-blind, controlled clinical trials of 12 weeks' duration, SEREVENT DISKUS 50 mcg was administered to 211 pediatric patients with asthma who did and who did not receive concurrent inhaled corticosteroids. The efficacy of SEREVENT DISKUS was demonstrated over the 12-week treatment period with respect to peak expiratory flow (PEF) and forced expiratory volume in 1 second (FEV1). SEREVENT DISKUS was effective in demographic subgroups (gender and age) of the population.
In 2 randomized studies in children aged 4 to 11 years with asthma and EIB, a single 50- mcg dose of SEREVENT DISKUS prevented EIB when dosed 30 minutes prior to exercise, with protection lasting up to 11.5 hours in repeat testing following this single dose in many patients.
Geriatric Use
Of the total number of adult and adolescent subjects with asthma who received SEREVENT DISKUS in chronic dosing clinical trials, 209 were aged 65 years and older. Of the total number of subjects with COPD who received SEREVENT DISKUS in chronic dosing clinical trials, 167 were aged 65 years and older and 45 were aged 75 years and older. No apparent differences in the safety of SEREVENT DISKUS were observed when geriatric subjects were compared with younger subjects in clinical trials. As with other beta2-agonists, however, special caution should be observed when using SEREVENT DISKUS in geriatric patients who have concomitant cardiovascular disease that could be adversely affected by betaagonists. Data from the trials in subjects with COPD suggested a greater effect on FEV1 of SEREVENT DISKUS in subjects younger than 65 years, as compared with subjects aged 65 years and older. However, based on available data, no adjustment of dosage of SEREVENT DISKUS in geriatric patients is warranted.
Hepatic Impairment
Formal pharmacokinetic studies using SEREVENT DISKUS have not been conducted in patients with hepatic impairment. Since salmeterol is predominantly cleared by hepatic metabolism, impairment of liver function may lead to accumulation of salmeterol in plasma. Therefore, patients with hepatic disease should be closely monitored.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 1/25/2017
Serevent Diskus FDA Prescribing Information
Additional Serevent Diskus Information
Serevent Diskus - User Reviews
Serevent Diskus User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Serevent Diskus sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Allergies & Asthma
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Report: Jeff Fisher On The Verge Of Choosing St. Louis Rams For Next Head Coaching Job
Former Titans coach Jeff Fisher has been looking to get back in the game, and according to a report out of St. Louis, he's nearing a decision, choosing the St. Louis Rams as his next head coaching gig.
Howard Balzer of 101sports.com reports that Fisher, who had narrowed to down his choices to the Rams and Miami Dolphins, is very close to choosing St. Louis. The decision isn't final, Balzer writes, but Fisher likes the Rams' roster and is on the verge of making a decision.
Fisher had a long, long run as the Titans' head coach, taking over in 1994 when they were the Houston Oilers. He was the longest-tenured head coach in the NFL when he and the Titans mutually agreed to a buyout in January 2011. He walked away with a career record of 142-120. The Rams went a dreadful 2-14 this season and haven't had a winning season since 2003. There's hope for the franchise down the road, however, as rising star quarterback Sam Bradford should be back in 2012, fully recovered from the high ankle sprain that dogged him this season.

subset: commoncrawl


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On Wednesday, Sept. 14th, Immaculate Heart Radio aired a special 30 minute interview with Walter Hoye, discussing the way abortion is affecting the African American community as well as his new Fatherhood Begins in the Womb campaign kicking off in Sacramento on September 14th. Mr. Hoye, having recently been victorious with his battle over free speech with the City of Oakland, is championing the Pro Life message stronger than ever.
Listen to the Interview[audio:http://ihradio.wpengine.com/wp-content/uploads/audio/walter-hoye.mp3]
Download the Interview (approx. 30mb)
Links relating to this story:
Podcast: Download (28.0MB)


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From the Editors
The Spring issue of the Arab Studies Journal is out! Click here.
Don't miss Tadween Publishing's latest blog entries at Al-Diwan. Click here.
Want to find out about new books? Visit our expanding NEWTON page. Click here.
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Check out our Reports Page and catch up on news, events, and announcements. Click here.
Interested in writing a Review for Jadaliyya? Visit our Call for Reviews here.
Visit Jadaliyya's awesome Photography Page. Click here!
This year, Jadaliyya turned five! Read about it here.
Call for Photos: Become a Contributing Photographer at Jadaliyya
The New York Times says Jadaliyya "Brings New Life to Arab Studies." Read about it by clicking here.
Jadaliyya was featured in the Chronicle of Higher Education. Click here for the story.
Khalid Tajani El-Nour
South Sudan: Post-Independence Opportunities and Challenges
Aug 01 2011
The independence of South Sudan, and the birth of the fifty-fourth state on the African continent, is a pivotal and historic event for the state of Sudan, and for the continent as a whole. The significance of the event goes beyond a mere change in the geographical boundaries of the divided country and the end of an era in its political history; its consequences will necessarily result in long-term change in the geopolitical realities of the region, and will lead to the ...Keep Reading »
Khalid Tijani El-Nour is a political commentator and editor-in-chief of the Sudanese business weekly Elaff.


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Holt Lodge Hotel
Select your stay dates to check availability
Holt Lodge Hotel
About the hotel
Property Location
Located in Wrexham, Holt Lodge Hotel is convenient to Clays Golf Course and Clays Golf Centre. This hotel is within close proximity of Wrexham Golf Club and Holt Castle.
Make yourself at home in one of the 37 guestrooms. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers. Conveniences include phones, as well as complimentary newspapers and coffee/tea makers.
Take in the views from a garden and make use of amenities such as complimentary wireless Internet access.
Grab a bite to eat at the hotel's restaurant, which features a bar, or stay in and take advantage of room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge.
Business, Other Amenities
Featured amenities include complimentary newspapers in the lobby, dry cleaning/laundry services, and luggage storage. Event facilities at this hotel consist of conference space and meeting rooms. Free self parking is available onsite.
Hotel Facilities
- Garden
- Free newspapers in lobby
- Free self parking
- Breakfast available (surcharge)
- Dry cleaning/laundry service
- Luggage storage
- Conference space
- In-room accessibility
- Meeting rooms
- Total number of rooms - 37
- Elevator/lift
- Accessible bathroom
- Bar/lounge
- Free WiFi
- Restaurant
Room Facilities
- Cable TV service
- Television
- Free WiFi
- Bathtub or shower
- Free newspaper
- Iron/ironing board (on request)
- Coffee/tea maker
- Rollaway/extra beds (surcharge)
- Room service (limited hours)
- Phone
- Hair dryer
- Private bathroom
- Free cribs/infant beds
Hotel Policy
National Rating
This property has received its official star rating from Visit Wales.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Rollaway bed fee: GBP 15.95 per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.Show all hotel policy Show less hotel policy


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New Genetic Link Found Between Normal Fetal Growth and Cancer »
"Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic under"...
Read the New Genetic Link Found Between Normal Fetal Growth and Cancer article »
Floxuridine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Floxuridine for Injection is a cancer (antineoplastic) medication used in the treatment of digestive system cancers that have spread to the liver. Floxuridine is available in generic form. Common side effects of floxuridine include:
- nausea and vomiting (may be severe)
- abdominal pain
- mild diarrhea
- loss of appetite
- weight loss
- tiredness
- redness at the injection site reactions (redness, pain, itching, swelling, bleeding blisters, or sores)
- dry skin
- redness of the palms of the hands or soles of the feet
- watery eyes
- balance problems
- confusion
- rash and itching, or
- temporary hair loss
The recommended therapeutic dosage schedule of floxuridine by continuous arterial infusion is 0.1 to 0.6 mg/kg/day. Floxuridine may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Floxuridine is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss birth control. It is recommended that men and women use 2 forms of birth control (e.g., condoms, birth control pills) while using this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding while using floxuridine is not recommended.
Our Floxuridine for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Floxuridine in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects from floxuridine, contact your doctor immediately:
- an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
- severe vomiting;
- diarrhea, frequent bowel movements or watery stools; or
- sores in the mouth or throat; or
- stomach pain or heartburn or black, bloody or tarry stools.
Other, less serious side effects may be more likely to occur. Continue taking floxuridine and talk to your doctor if you experience:
- mild to moderate nausea, vomiting or loss of appetite;
- redness of the palms of the hands or soles of the feet;
- increased eye watering;
- balance problems;
- confusion;
- rash and itching; or
- temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Floxuridine (Floxuridine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Floxuridine Overview - Patient Information: Side Effects
Temporary hair loss may occur. Normal hair growth should return after treatment has ended.
Many people using this medication have some serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects.
This medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection such as fever or chills.
Tell your doctor right away if you have any serious side effects, including: mouth sores, sore throat, painful/difficult swallowing, persistent or severe vomiting/diarrhea, easy or unusual bruising/bleeding, black stools, blood/mucus in the stools, vomit that looks like coffee grounds, cramps/pain in the stomach/abdomen, yellowing eyes/skin, dark urine, weakness, weight loss, skin problems (e.g., unusual sunburn, peeling/darkening of the skin), muscle/joint pain.
Get medical help right away if any of these rare but very serious side effects occur: chest/jaw/left arm pain, warmth/swelling/pain/leaking at the injection site, pain/swelling/redness/weakness of the arms or legs, calf pain/swelling that is warm to the touch, shortness of breath, coughing up blood, sudden vision changes, weakness on one side of the body, severe clumsiness/trouble walking, slurred speech, confusion, severe headache.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Floxuridine (Floxuridine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Floxuridine FDA Prescribing Information: Side Effects
(Adverse Reactions)
Adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion.
The more common adverse reactions to the drug are nausea, vomiting, diarrhea, enteritis, stomatitis and localized erythema. The more common laboratory abnormalities are anemia, leukopenia, thrombocytopenia and elevations of alkaline phosphatase, serum transaminase, serum bilirubin and lactic dehydrogenase.
Other adverse reactions are:
Gastrointestinal: duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain; possible intra- and extrahepatic biliary sclerosis, as well as acalculous cholecystitis.
Dermatologic: alopecia, dermatitis, nonspecific skin toxicity, rash.
Cardiovascular: myocardial ischemia.
Miscellaneous Clinical Reactions: fever, lethargy, malaise, weakness.
Laboratory Abnormalities: BSP, prothrombin, total proteins, sedimentation rate and thrombopenia.
Procedural Complications of Regional Arterial Infusion: arterial aneurysm; arterial ischemia; arterial thrombosis; embolism; fibromyositis; thrombophlebitis; hepatic necrosis; abscesses; infection at catheter site; bleeding at catheter site; catheter blocked, displaced or leaking.
The following adverse reactions have not been reported with floxuridine but have been noted following the administration of 5-fluorouracil. While the possibility of these occurring following floxuridine therapy is remote because of its regional administration, one should be alert for these reactions following the administration of floxuridine because of the pharmacological similarity of these two drugs: pancytopenia, agranulocytosis, myocardial ischemia, angina, anaphylaxis, generalized allergic reactions, acute cerebellar syndrome, nystagmus, headache, dry skin, fissuring, photosensitivity, pruritic maculopapular rash, increased pigmentation of the skin, vein pigmentation, lacrimal duct stenosis, visual changes, lacrimation, photophobia, disorientation, confusion, euphoria, epistaxis and nail changes, including loss of nails.
Read the entire FDA prescribing information for Floxuridine (Floxuridine)
Floxuridine FDA Prescribing Information
Additional Floxuridine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get the latest treatment options.


text:
Bellville Times
Services are pending for Elizabeth Skalak who died Sunday, Dec. 2, at the age of 93. She was born March 8, 1914 in Bellville, the first of 10 children born to Henry J. and Maude (Colleton) Kenter. On June 3, 1936 she married Lloyd Skalak in Bellville and together they raised four children. Survivors include two sons, Jimmy Skalak of Seadrift and his wife Barbara, and Tom Skalak of Freeport and his wife Dorissa; one daughter, Cindy Payne of Casper, Wyoming and her husband Jim; one sister, Mary Jane Gordon of Bellville; and numerous grandchildren, step-grandchildren and great grandchildren. She was preceded in death by her husband, five siblings who did not survive infancy, two brothers, one sister, one son and one grandson.
Posted by Joy Neely


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Gift planning
Women are changing lives with money
In fact, that's how Women of the ELCA got started. In the early 1800s, Ladies Aid circles formed to help congregations build their first sanctuaries and pay pastor's salaries. When the larger church would not support single women as missionaries, women's mission circles raised the dollars and sent women to serve overseas as nurses, teachers, and translators.
Gift planning is part of this tradition. Women of all income levels are using gift plans to make lasting impact on ministry, and provide for their loved ones.
Today, women give millions each year to Women of the ELCA and other ELCA ministries to support advocacy and education, eradicate malaria, resist racism, improve maternal and child nutrition, help disaster victims, and grow the church.
How can my giving make a bigger impact on mission and ministry? How can I support the church while providing for my family and meeting my own financial needs?
These are questions that women of faith have been asking--and answering--for generations. Gift planning starts here.
Find your regional gift planner.
Learn more about wills and bequests, annuities, life income gifts, and free gift planning services from the ELCA Foundation.
I give to Women of the Evangelical Lutheran Church in America, a Minnesota nonprofit corporation, c/o The ELCA Foundation, located at 8765 West Higgins Road, Chicago, Illinois 60631, the sum of $___ [or ___percentage of my estate] for the benefit of: [specific ministry, i.e. Katie's Fund, Women of the ELCA General Fund, Women of the ELCA Scholarships]
The material presented on this gift planning website is provided for educational purposes and should not be considered tax or legal advice. Please consult with your tax or legal advisor before proceeding with your estate plan.


text:
SPORTKINGS Series F - who do you want to see?
Now that Series E has been out a while, time to start looking ahead to Series F :D
Here's what I thought I would do...
1) Start a thread nominating athletes for Series F (this thread)
2) On August 31st, open two threads (one for team sports, one for individual sports) in which people can vote for their top 50 in each category
3) On October 31st, take the top 50 from each of the two preliminary threads and start a new thread in which people can vote for their final 48 athletes (since this is the usual size of a series) of of the 100 listed.
4) On December 31st, announce the final vote tally...
So this will become the nominating thread. For sanity's sake, please only nominate athletes who are no longer active, since I already have a list of 200+ retired athletes, and Dr. Price generally does not include more than 2-3 active athletes in each series. Also, keep in mind that Michael Jordan, Wayne Gretzky, and Bobby Orr are not included because they are under exclusive contract to Upper Deck.
Here goes:
[B][U]Team Sports[/U][/B]
Feller (Baseball)
Spahn (Baseball)
Mantle (Baseball)
DiMaggio (Baseball)
Campanella (Baseball)
Aaron (Baseball)
Sadaharu Oh (Baseball)
Koufax (Baseball)
Mays (Baseball)
Berra (Baseball)
Mathews (Baseball)
Killebrew (Baseball)
Drysdale (Baseball)
F.Robinson (Baseball)
B.Robinson (Baseball)
McCovey (Baseball)
Stargell (Baseball)
Palmer (Baseball)
Morgan (Baseball)
Brett (Baseball)
Yount (Baseball)
Munson (Baseball)
Fisk (Baseball)
Boggs (Baseball)
Puckett (Baseball)
Maddux (Baseball)
Glavine (Baseball)
R.Johnson (Baseball)
P.Martinez (Baseball)
Bonds (Baseball)
O.Graham (Football)
Tittle (Football)
Blanda (Football)
Bradshaw (Football)
Staubach (Football)
Payton (Football)
Swann (Football)
Campbell (Football)
Fouts (Football)
Lott (Football)
E.Smith (Football)
Favre (Football)
Cousy (Basketball)
Abdul-Jabbar (Basketball)
Erving (Basketball)
Havlieck (Basketball)
Reed (Basketball)
Bradley (Basketball)
Moses Malone (Basketball)
Gervin (Basketball)
Drexler (Basketball)
Pippen (Basketball)
Ewing (Basketball)
Mullin (Basketball)
Stockton (Basketball)
Karl Malone (Basketball)
O'Neal (Basketball)
Yao Ming (Basketball)
Manute Bol (Basketball)
Sarunas Marciulonis (Basketball)
Gordie Howe (Hockey)
Mikita (Hockey)
Dryden (Hockey)
Clarke (Hockey)
L.Robinson (Hockey)
Bossy (Hockey)
Trottier (Hockey)
Potvin (Hockey)
Eruzione (Hockey)
Coffey (Hockey)
Bourque (Hockey)
Yzerman (Hockey)
Hasek (Hockey)
Lidstrom (Hockey)
Larionov (Hockey)
Puskas (Soccer)
B.Moore (Soccer)
B.Charlton (Soccer)
Beckenbauer (Soccer)
Cruyff (Soccer)
Maradona (Soccer)
P.Rossi (Soccer)
Platini (Soccer)
Matthaus (Soccer)
Baresi (Soccer)
Baggio (Soccer)
Maldini (Soccer)
Stoichkov (Soccer)
Hagi (Soccer)
Zidane (Soccer)
Bergkamp (Soccer)
Yashin (Soccer)
Banks (Soccer)
Shilton (Soccer)
Schmiechel (Soccer)
Kahn (Soccer)
Gullit (Soccer)
Rijkaard (Soccer)
Van Basten (Soccer)
Lalas (Soccer)
Wynalda (Soccer)
Harkes (Soccer)
Meola (Soccer)
Reyna (Soccer)
Cobi Jones (Soccer)
McBride (Soccer)
Keller (Soccer)
Michelle Akers (Soccer)
[B][U]Individual Sports[/U][/B]
Laver (Tennis)
B.J.King (Tennis)
McEnroe (Tennis)
Connors (Tennis)
Evert (Tennis)
Graf (Tennis)
Agassi (Tennis)
Sampras (Tennis)
Seles (Tennis)
Chang (Tennis)
Courier (Tennis)
Joe Louis (Boxing)
Patterson (Boxing)
Liston (Boxing)
Foreman (Boxing)
Spinks (Boxing)
Duran (Boxing)
Hagler (Boxing)
Hearns (Boxing)
Watson (GOLF)
Ballesteros (GOLF)
Trevino (GOLF)
Faldo (GOLF)
Player (GOLF)
Sarazen (GOLF)
Vardon (GOLF)
Carl Lewis (Track)
Killy (Skiing)
O'Brien (Track)
Jansen (Speed Skating)
Daley Thompson (Track)
Rafer Johnson (Track)
Mary Lou Retton (Gymnastics)
Bubka (Pole Vault)
Gail Devers (Track)
Felix Savon (Boxing)
Teofilio Stevenson (Boxing)
Alexis Karelin (Wrestling)
Matt Biondi (Swimming)
Gary Hall (Swimming)
Janet Evans (Swimming)
Steve Mahre (Skiing)
Phil Mahre (Skiing)
Tomba (Skiing)
Ohno (Speed Skating)
N.Coughlin (Swimming)
de Bruijn (Swimming)
Aamodt (Skiing)
Bill Johnson (Skiing)
Tommy Moe (Skiing)
Tony Sailer (Skiing)
Franz Klammer (Skiing)
Lasse Kjus (Skiing)
J.Kostelic (Skiing)
Bjorn Daehlie (Cross Country Skiing)
Boitano (Figure Skating)
K.Witt (Figure Skating)
N.Kerrigan (Figure Skating)
Yamaguchi (Figure Skating)
Kwan (Figure Skating)
Georg Hackl (Luge)
Matti Nykanen (Ski Jumping)
J-O Koss (Speed Skating)
Fittipaldi (AUTO)
Foyt (AUTO)
Mears (AUTO)
the Unsers (AUTO)
Earnhardt (AUTO)
Bobby Allison (AUTO)
C.Yarbrough (AUTO)
D.Waltrip (AUTO)
Edmund Hilary (Mountain Climbing)
Neil Armstrong (Aviation)
Y.Gagarin (Aviation)
Randy "Macho Man" Savage (Professional Wrestling)
Amarillo Slim (Poker)
Lance Armstrong (Cycling)
Greg Lemond (Cycling)
Miguel Indurain (Cycling)
Bernard Hinault (Cycling)
Rick Swensen (Iditarod)
Lance Mackey (Iditarod)
Martin Buser (Iditarod)
Jeff King (Iditarod)
Doug Swingley (Iditarod)
Landry (COACH)
Noll (COACH)
Walsh (COACH)
Bryant (COACH)
Torre (MANAGER)
Cox (MANAGER)
Anderson (MANAGER)
LaRussa (MANANGER)
Lasorda (MANAGER)
Weaver (MANAGER)
Auerbach (COACH)
Nelson (COACH)
Jackson (COACH)
Riley (COACH)
Anybody else you can think of that meets the guidelines feel free to suggest up until August 31st....
You just had MLB's HOF add some people. Larkin and Santo.
Kurt Angle
Olympian and pro wrestler
In light of the Olympics how about Mark Spitz.................
Let's just keep in mind all the relevant factors that have already been discussed in prior threads before we jump into this;
The problem with a "top 48" poll is it will merely trickle down to the top $$$ players and we've already tackled the imaging rights to some of those athletes are quite high even just to do base cards of them as you would like.
Combine that with some athletes (or their handlers) not even opting into the program despite Dr. Price's best efforts and that will knock out a certain percentage of any top 48 list automatically. So where's the end result here? Just a "wish list" which is fine, but not realistic.
I had fun last time we threw ideas out there for some of the lesser known sports. It contributed some pretty interesting ideas and names I hadn't heard of before and liked looking up.
[QUOTE=hanes1111;3021310]In light of the Olympics how about Mark Spitz.................[/QUOTE]
He was in their first release, Series A, with on-card autos, etc. :)!
[QUOTE=Rinkwraith;3021396]The problem with a "top 48" poll is it will merely trickle down to the top $$$ players and we've already tackled the imaging rights to some of those athletes are quite high even just to do base cards of them as you would like.[/QUOTE]
I think you'll be surprised...I know that quite a few of the guys in my final 60 (I haven't cut it down to 48 yet) are not big money guys, and I'm sure the same will hold true for many of the other posters....
[QUOTE=mfw13;3022272]I think you'll be surprised...I know that quite a few of the guys in my final 60 (I haven't cut it down to 48 yet) are not big money guys, and I'm sure the same will hold true for many of the other posters....[/QUOTE]
Individually, no doubt. My top 48 would have Katarina Witt, Gabriella Sabbatini, Gabrielle Reece and Jake "The Snake" Roberts (still waiting for the snakeskin boot memorabilia autos). I think everyone's bottom 10-15 would be fun and unique, but statistics catches up with you over more people as the top 20-30 are all the high dollar signers or hard to get people.
All I'm saying is just don't have the expectation of having the grand master list of "here's who we expect to have in version F". It'll be a nice wish list, but it's fun just being able to shout out one name or two and actually seeing Dr. price incorporate it into the product. It happened last year and I'm sure he'll be listening to new ideas this year as well.
milan legend on card and boxing legend
but liston difficult except cut auto
auto and memorabilia from foreman were be extra ! :)!
[QUOTE=Rinkwraith;3022338]All I'm saying is just don't have the expectation of having the grand master list of "here's who we expect to have in version F". It'll be a nice wish list, but it's fun just being able to shout out one name or two and actually seeing Dr. price incorporate it into the product. It happened last year and I'm sure he'll be listening to new ideas this year as well.[/QUOTE]
From my perspective, the idea is to:
A) have fun
B) provide Dr. Price with some useful data both about which sports are and are not popular, as well as which athletes within each sports are most popular
Boris Becker. Pretty much all the people the OP listed for tennis aren't all that hard to get in terms of an auto from Ace. Since I have been collecting tennis I haven't seen anything pop up of Becker in terms of auto cards/balls.
Please remember that some athletes have exclusives with other card companies when creating your lists.
Thanks for the interest in Series F.
Brian Price
Okay, some early Olympic suggestions;
Ellen Hoog (women's field hockey) -- I'm pretty sure any orange memorabilia cards would sell pretty well; [URL="http://www.blowoutcards.com/forums/off-topic/342236-dutch-field-hockey-team.html"]http://www.blowoutcards.com/forums/off-topic/342236-dutch-field-hockey-team.html[/URL]
Dana Vollmer (swimming) - looks to have a great Olympics
Kim Rhodes (rifle) - maybe not a great $ choice and she is in Topps Olympics set, bet medaling in 5 straight Olympics is the definition of a Sportking.
other swimmers I think might be a good addition
Kosuke Kitajima (Japan)
Aaron Peirsol (USA)
Lenny Krayzelburg (USA)
Kirsty Coventry (South Africa)
Dara Torres (USA)
Amanda Beard (USA)
personal bias here Brendan Hansen (USA)
Why, oh why, would you have over twice as many soccer players than hockey players on your list? I think the point is to add value, not subtract it.
[QUOTE=oldgoldy97;3053778]Why, oh why, would you have over twice as many soccer players than hockey players on your list? I think the point is to add value, not subtract it.[/QUOTE]
Because most of the major hockey players who do not have exclusive contracts with other companies have already appeared in Sportkings....
[QUOTE=bprice;3027825]Please remember that some athletes have exclusives with other card companies when creating your lists.
Thanks for the interest in Series F.
Brian Price[/QUOTE]
Dr. Price, would it be possible for you to post a list of which athletes have exclusives with other companies? Upper Deck's exclusives with Jordan, Gretzky, and Orr are well-known, but it would be nice to know about all the others...
Mia Hamm
Michael Phelps
Alexi lalas
Alex morgan
Hope Solo
Dick Trickle
Michael Waltrip
Spud Webb
Ricky 'the dragon' steamboat
'Mr Wonderful' Paul Orndorff
Keri Strug
Nancy kerrigan
Tony Hawk
Mike Metzger
Shaun White
Keri Walsh/Misty May Traynor
Peekaboo Street
Bode Miller
Dr. Price,
any chance of a steve prefontaine mem. card?
Here are a few suggestions:
Archie Stark (soccer) - record holder for most goals in a season (61) until Messi broke it in 2012.
George Best (soccer) - legend, legend, legend - if Upper Deck doe not own rights.
Gordon Banks (soccer) - arguably best post-war GK ever.
Ricardo Zamora (soccer) - great pre-war legend. would have been in the original 1930's series if it was international.
Dixie Dean (soccer) - Everton, pre-war legend (see above)
Alex Jackson (soccer) - played in USA and became legend in Britain
Kenny Dalglish (soccer) - King Kenny !
I would buy this series for a chance for any of these cards.
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[Date Prev][Date Next][Thread Prev][Thread Next][Date index][Thread index]
st: Re: GMM or 2SLS with cluster adjustment or others
Kit Baum <firstname.lastname@example.com>
st: Re: GMM or 2SLS with cluster adjustment or others
Wed, 14 May 2008 10:17:18 -0400
The Arellano-Bond / Arellano-Bover / Blundell-Bond methodology (xtabond, xtabond2) is appropriate if you have lagged dependent variables, and unnecessary otherwise.
If you have a panel with endogenous regressors, use xtivreg2 with cluster-robust SEs, preferably with the gmm2s option.
See Baum-Schaffer-Stillman, Stata Journal 7:4 2007, for details. Preprint available from my homepage below as a BC working paper.
Kit Baum, Boston College Economics and DIW Berlin
An Introduction to Modern Econometrics Using Stata:
On May 14, 2008, at 02:33 , statalist-digest wrote:
I have panel data and would like to adjust for potential
autocorrelation in the dependent variable as well as the
endogeneity in one of the independent variables. Would 2SLS with
cluster adjustment (i.e. ivreg with cluster option) be sufficient?
I was suggested to use the Arellano-Bond (1991)/Arellano-Bover
(1995) estimation procedure. I assume it is GMM. Would that be
necessary? How do these two methodologies differ? Thanks.
* For searches and help try:
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text:
Investing is a tough game, and extremely unforgiving, so needs a disciplined process.
Ditch rose-coloured glasses:
Be disciplined and ruthless. Look at the pros and cons. Make haste slowly.
Time: Very few investments will work well if you don't give them time. A balanced portfolio needs five to seven years for best results.
Short-term trading and speculating is different, and can be very risky.
Work out an asset allocation that meets your risk profile: Decide on one, for example 33 per cent bonds, 33 per cent property and 33 per cent shares. There are many variations. Decide then stick to it.
Rebalance regularly: Allow a tolerance of, say, 5 per cent and then rebalance. This is an essential discipline yet it's a simple tool, too. Do it or pay the price.
Buy quality: Junk bonds might pay a higher yield but, if they do, the risk will be higher - no exceptions. Higher yielding property will usually be higher risk, have little potential capital gain, or be in a waning provincial town - lesser quality. No one ever did badly buying quality.
If in doubt, do half : This is one of the best rules I know. It can apply to buying or selling just about any investment: loans to children, helping a wayward brother, and so on.
Average into investments over time: A logical extension of half now and half later. Once you have decided to invest, buy half now and half in 6 or 12 months (really easy to do with bonds and shares). Then stick to your planned date, and don't second guess the marketplace.
If you buy half now and it does well, you are glad you invested. If it falls, you can buy cheaper in 6 or 12 months.
Diversify widely: Understand this and do it. Diversifying is more or less free, too. Last year, New Zealand shares returned 30 per cent and global shares 15 per cent. This year, New Zealand shares (to October) have risen about 12 per cent, and global shares are up over 20 per cent. Few people (if any) would have predicted these returns, so diversifying across both has worked well. Diversify on and offshore too, since the small New Zealand economy lacks diversity, and is horribly exposed to earthquakes and imported diseases.
Investing in just a few shares: Investing in a few shares is playing. Can be fun, and you might get lucky, but is not serious investing.
Get experienced independent advice: There are very few truly independent advisers - only about 300 countrywide.
Free advice is usually worth what it costs: Free advice is usually offered to get you in the door - to sell you their services or products.
Buy liquid investments: Very few investments nowadays offer any advantage by being locked in, except maybe property.
Liquid investments can double as emergency funds, too, so why not. A good reason to have other investments as well as property.
Don't try to invest based on forecasting or stock picking:
I can't find anyone who can consistently pick stocks, forecast interest or exchange rates or economic events. They don't exist. Use this checklist and you won't go far wrong.
Check costs, fees and commissions: All matter, some are worth paying, but paying stock pickers and forecasters is usually wasted money. Perhaps the worst cost can be the person on commissions or bonuses who wants to sell you something that is good for him or her, but not necessarily good for you.
Do not allow fear or greed to influence your decisions: Dalbar (USA) research indicates that the average DIY investors gets about 50 per cent less return than they should. It is thought they fail mainly as they react to fear or greed; sell out near the bottom when things look bad; buy near the top when things look good.
Avoid new high fliers: Fiduciary guidelines say trustees should not invest if an investment does not have a three-year track record, is not of a reasonable size and is liquid.


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2011: Did not see any action for the Blazers in his first year at UAB.
High School: Attended Isabella High School ... coached by Scott Booth at Isabella ... started at quarterback as a senior ... connected on 35-of-70 passes for 591 yards with 10 touchdown passes as a senior ... was outstanding runner as he rushed for 1,511 yards on 207 attempts (7.3 avg.) with 12 touchdowns on the ground ... averaged 137.4 rushing yards per game ... also played basketball and baseball at Isabella.
Personal: Born Nov. 23, 1992 ... son of Betty and Jerry Haigler ... major is liberal arts.


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2017 is the 70th Anniversary Year for the Antonov AN-2, first flight was 31st August 1947
2017 is the 70th Anniversary Year for the Antonov AN-2, first flight was 31st August 1947
The Antonov AN-2 Club was formed 20 years ago to encourage interest in "the worlds' biggest biplane", to keep suitable examples in flying condition and create opportunities to experience the AN-2 in flight.
The Club helps members enjoy recreational activities involved with flying such as visiting air shows, aviation museums and historic airfields in the UK and Europe.
The Club's Hungarian registered AN-2, HA-MKF, provides introductory club flights and participates in flying displays and events both in the air and as a static exhibit.
There are opportunities for members to share the cost of flights to a variety of airfields and for pilots with at least a PPL to experience flying the AN-2.
Whenever operational conditions allow, we are always happy to open the aircraft for a close up view of the passenger cabin and cockpit.
Judging by the very positive reaction from the public, the AN2 made our event one to remember. Your display was truly unique and captivated the crowd who were very entertained. Our air traffic control were amazed at the aircraft.
I have been asked to pass on sincere thanks for a memorable day. I can understand how you get such a buzz in being captain of such a wonderful machine.
Keep updated on the very lastest information on the Antonov AN2 Club via Facebook and Twitter.


text:
WS-32-SN Washington Square Collection Wall Mounted Soap Dish, Satin Nickel by Allied Brass
Product ID:
Price Quote
when buying in bulk
- Classic design will compliment your décor
- Satin Nickel, a lightly brushed warm grey metallic look that helps resist fingerprints
- Made of Solid Brass
- Available in a variety of designer finishes
- Assembled in the U.S.A.
Complete your décor with this finely crafted soap dish. Keep your countertop clean and clutter free while adding the finishing touch to your space. Made of solid brass and provided with a lifetime finsh to insure products will never rust.


text:
Sensitive and Confidential Materials Statement for Collections
This archival collection may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations.
Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in this collection without the consent of those individuals may have legal ramifications (e.g., a cause of action under common law for invasion of privacy may arise if facts concerning an individual's private life are published that would be deemed highly offensive to a reasonable person) for which Indiana University South Bend assumes no responsibility.
Last Reviewed: 03/2014


text:
MXP is a potentially psychedelic dissociative compound of the piperidine class. Methoxphenidine is structurally analogous to Diphenidine, containing an additional 2-methoxy CH3O- substitution.
MXP is often mentioned in relation to other research chemical, MXE. However, despite some similarities in the chemical structure (since both are NMDA antagonists), the connection between these two compounds are not as prominent as one might assume.
This product is meant strictly for forensic, chemical analysis, collectible and research purposes. Under no circumstances it is intended for human consumption.


text:
Create a free account to check out faster, store multiple shipping addresses, view and track your orders in your account, and much more.
Please enter your password to continue.
I've inly used these twice, on my bottom lashes. they did work, but not as I wanted them to, but I think that was because I used a different mascara as well. I have yet to try these on my too lashes. i will soon though! I imagine they'll work well. I'm actually excited to try them. also! you can use 1 single card multiple times, even though it said not to. oops! but I can't justify using it once when it certainly can be used over again!4


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New Zealand No 1 Danny Lee enjoyed a top 15 finish at the Sony Open after carding a one under par 69 in the final round at the Waialae Country Club in Hawaii today.
The 22-year-old Rotorua professional, who won the pre-qualifying tournament with a seven under par 65, finished in a share of 13th place, 11 shots back from champion American Russell Hanley, who won in his first event on the PGA Tour.
Lee, the former World No 1 amateur who suffered the heartache of missing qualifying for a full card on the PGA Tour by one shot in 2012, was back to his best on the big stage this week in Honolulu.
He had three consecutive rounds of four under par 66 in the first event of the 2013 season as he made a run at his first PGA Tour win.
The former US Amateur Champion was looking to make a fast start today. He birdied the second hole to get within five shots of the leaders before making a costly double bogey on the fourth.
But he rallied coming home with birdies on nine, 12 and 13 to get to two under for the day before dropping a shot at the par four 17th.
Lee needed to win to get back on the PGA Tour - had he won he would have earned an exemption for 2013 and the following two years.
But any results and money made on the main tour will promote his chances of returning to the PGA Tour in 2014 where he needs to finish inside the top 125 players on the money list.
He needs to make the most of every start he can muster on the PGA Tour through pre-qualifying and tournament invites he receives and has performed well in his first effort for 2013.
Fellow Kiwi Steve Alker, who also reached the event through qualifying, missed the cut with rounds of 72 and 68.


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Pirates Notebook
Pirates Notebook: With Morton on DL, Roster Decisions Loom
Pirates Notebook
BRADENTON, Fla. -- After placing right-hander Charlie Morton on the disabled list to start the 2012 season, Huntington said the decision to carry an extra bench player, rather than an arm, is still in discussion. Instead of carrying 12 pitchers, the Pirates could decide to use 11 arms (four starters and seven relievers) and 14 position players to help the club during their tough month of April.
"That is an option," Huntington said. "That is something we are talking about. The best use of the bench for Clint to win those early games. Eight bullpen guys allows us the protection early as your starters are getting built up, getting into the cold weather. It is an option that we could go 11 pitchers, [14] position players. Or we could go four starters and eight relievers and go 12 and 13. We...
This content is for Pirates Prospects subscribers only. Subscribers get access to all of our daily articles on the Pirates and their minor league system, with live coverage throughout the system on a daily basis. Our lowest rates are $2.22 per month under our Top Prospect Plan, which also gets you a 40% discount on the 2017 Prospect Guide. Subscribe today to access all of our daily coverage of the Pirates' system.
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text:
The basketball state tournament opened Tuesday night with the Division III boys and continues tonight. Eight local girls teams play as Divisions I, II and III get their tournaments under way. Here are Tuesday night's results:
• No. 11 Thatcher 70, No. 22 Empire 54: At Thatcher, the Eagles outpaced the Ravens to snap a two-game losing streak and end Empire's season at 16-12. It was the team's fourth loss in the final six games.
Empire sophomore Deion James had scored at least 18 points in six of the previous seven games before Tuesday night's season-ending loss.
• No. 16 Show Low 64, No. 17 Benson 60: At Show Low, the Bobcats suffered their second straight loss, dropping out of the Division III state tournament. Benson started the season 8-1 and finished with a 20-10 mark.
• No. 18 Safford at No. 15 Rio Rico: The game was postponed until today at 7 p.m. because of weather conditions that caused the Santa Cruz Valley School District to cancel classes Tuesday.
Rio Rico (18-10) had won six straight games before losing in the section tournament to second-ranked Gilbert Christian.
Division I: First round, 7 p.m.
• No. 24 Scottsdale Chaparral at No. 9 Sierra Vista Buena
• No. 21 Yuma Cibola at No. 12 Mountain View
• No. 19 Mesa Mountain View at No. 14 Tucson
• No. 23 Cienega at No. 10 Tolleson
Division II: First round, 7 p.m.
• No. 20 Laveen Fairfax at No. 13 Canyon del Oro
• No. 22 Sabino at No. 11 Phoenix Arcadia
• No. 19 Pusch Ridge Christian at No. 14 Phoenix South Mountain
Byes: No. 6 Flowing Wells, No. 7 Sahuaro
Division III: First round, 7 p.m.
• No. 18 Benson at No. 15 Buckeye
Byes: No. 8 Safford


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I have a digital book I recieved as a gift I want to download it to my Touch how do I do this? It always goes in as music instead of a book and then I have a hard time listening to it. Also is there a way to mark where I left off? I can go days without listening to it and I always have to find my place it doesn't just automatically open to where i left off. Any help would be appreciated.
How-To Geek Forums / Apple / OS X
(Solved) - IPod Touch(3 posts)
Topic Closed
This topic has been closed to new replies.


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ED Magedson – Founder
Ripoff Report
Evia Auto Sales Queensburry NY599 Aviation Rd. Queensburry , New York USA
Evia Auto Sales Queensburry NY They scam, sell lemons, and ruin lives Queensburry New York
Does your business have a bad reputation?
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Corporate Advocacy Program™
I don't know how these crooks sleep at night! After reading other peoples reviews on the BBB site, and others I now know we are not the only ones to get ripped off and sent on our way with them.
We went there looking for an suv since I do wildlife rehab and we also have three kids. The sales person seemed to be helpful and pleasant during our purchase. We traded in a working, reliable Mercury Sable Sedan towards a Nissan Xterra. It needed an new exhaust which they put on before we brought it home. We were told it was mandatory that we needed to purchase an extended 2 year 24,000 mile warranty that had a hefty price tag. Which we found out is a lie. We were also told they did an alignment and checked out the entire truck. After getting it home we noticed the transmission was slipping and the exhaust was loud. We called them to set up and appointment and they kept rescheduling till after a month goes by and they're warranty policy was up where we could not return or get a different car.
After two months the transmission starts to make noise and we finally got an appointment to go see them. We were told we could not stay at the dealership while they were checking it over and made us walk elsewhere to get out of the weather. It was in the 20's that day, and I was pregnant. After a few hours of hearing nothing we call them and they said we need to get our asses back there because it wasn't good. They proceeded to tell us that we had caused the wear and tear on the truck, and gave us a list of issues including the allignment which they said they don't take care of there but told us they did when we bought it, the inside of the tires were going baled because of bad axle, skid plate was on with only two bolt, the muffler was installed wrong, no E break, a broken bearing arc, and they would have to tear down the engine to figure out the noise which would not be covered. They would not cover any of the problems and the work would cost thousands. We were a bit irate at this point since the mechanic accused us of all of the issues and was very rude. We told them we needed to discuss what we wanted to do and promptly left.
We decided to take it to Saratoga Nissan near our home after they offered to listen to it for free. We were told it was not the engine but likely the transmission. We called the Warranty company ourselves after we were threatened not to by Evia. They told us we could take it to any garage for warranty work. We left it off with the Nissan dealer and after doing a complete tear down of the transmission told us the bolts were not on tight and the warranty company would not cover it since it was not a faulty transmission but was caused by a mechanics error. We were told it would cost over eight thousand dollars to fix the truck. All of this went on during the Christmas Holiday and resulted in the loss of Eric's job, and our only form of transportation. Please do not do buy anything from these people!
This report was posted on Ripoff Report on 12/31/2013 02:47 PM and is a permanent record located here: http://www.ripoffreport.com/reports/evia-auto-sales-queensburry-ny/queensburry-new-york/evia-auto-sales-queensburry-ny-they-scam-sell-lemons-and-ruin-lives-queensburry-new-yo-1111974. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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(1901-78) a US anthropologist (= person who studies the human race). She studied how children grow up in different cultures, especially in the Pacific islands, and argued that human behaviour is strongly affected by society. Some people criticized her research, but she made anthropology very popular. Her books included Coming of Age in Samoa (1928), Growing Up in New Guinea (1930), Male and Female (1949) and Culture and Commitment (1970).jump to other results
Margaret Mead
BrE ; NAmE
Check pronunciation: Margaret Mead


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By applying after assembly an adhesive, solvent or chemical activating agent
Subclass of:
156 - Adhesive bonding and miscellaneous chemical manufacture
156060000 - Surface bonding and/or assembly therefor
Patent class list (only not empty are listed)
Deeper subclasses:
|Class / Patent application number
|Number of patent applications / Date published
|By applying after assembly an adhesive, solvent or chemical activating agent
|COMPOSITION FOR APPLICATION TO A SURFACE - Compositions, methods, apparatuses, kits, and combinations are described for permanently or temporarily re-designing, decorating, and/or re-coloring a surface. The compositions useful in the present disclosure include a décor product that is formulated to be applied and affixed to a surface. If desired, the décor product may be substantially removed from the surface before being affixed thereto. If a user desires to remove the décor product, the décor product is formulated to be removed by a number of methods including, for example, vacuuming, wet extraction, chemical application, and the like. If the user desires to affix the décor product to the surface in a permanent or semi-permanent manner, the décor product may be affixed to the surface by applying energy thereto in the form of, for example, heat, pressure, emitted waves, an emitted electrical field, a magnetic field, and/or a chemical. The décor product may also be utilized in the form of a kit or in conjunction with a design device, such as a stencil, to control the application of the décor product to create, for example, a pattern on the surface.
|METHOD AND APPARATUS FOR LAYER BONDING OF DISPLAY ASSEMBLY - A method and apparatus for the bonding of one or more material layers (
|FLATTENED TUBULAR MESH SLING AND RELATED METHODS - The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to multilayer mesh slings formed from a tubular mesh material.
|METHOD OF MANUFACTURING AN ELONGATED COMPOSITE STRUCTURE - A method of manufacturing an elongated composite structure having two separate longitudinal composite structure sections, where said method comprises the following steps: providing a rigid mould part
|ORGANIC LIGHT-EMITTING DEVICE, AND METHOD FOR MANUFACTURING ORGANIC LIGHT-EMITTING DEVICE - The present invention provides an organic light-emitting device which can prevent a covering member from being damaged or peeled off, and which can be manufactured with excellent productivity and cost performance; and a method for manufacturing the organic light-emitting device. The covering member has a chamfer formed on the side of a face of the covering member on a reverse side to the side of an organic light-emitting element.
|REACTIVE HOT MELT ADHESIVE COMPOSITION AND METHOD FOR PRODUCING THE SAME - Disclosed are a reactive hot melt adhesive composition having no problem in the initial adhesive strength, the adhesive strength obtained after moisture curing, stringiness and the like, and a method for producing the same. In the method, 1 to 50 parts by mass of a polymer (A), which is obtained by polymerization of a monomer composition including a vinyl monomer having a carboxyl group and a vinyl monomer having an epoxy group and has the equivalent ratio of the carboxyl group to the epoxy group in the range of 1/100 to 100/1, is mixed with 99 to 50 parts by mass in total of a polyisocyanate (B) and a polyol (C) so that the amount of the isocyanate group can become 1.1 to 10 moles relative to 1 mole of the hydroxyl group of the polyol (C), the sum of the components (A) to (C) being 100 parts by mass, and the resulting mixture is heated and mixed.
|LIQUID ADHESIVE - A low-expanding adhesive composition comprising: a diisocyanate, a surfactant and an activator is provided. The provided adhesive composition cures upon exposure to water. The adhesive composition can be used to bond wood, metal, glass, ceramic, leather, acrylic, PVC and combinations thereof.
|Method for the adhesion of windowpanes - A method for the adhesion of windowpanes (
|USE OF SWELLABLE POLYMER FOR SEALING - Use of a swellable polymer for sealing, wherein the polymer is obtainable by polymerizing a composition which comprises at least one polyalkylene glycol di(meth)acrylate having a weight-average molecular weight greater than 2500 g/mol.
|ATTACHMENT MEMBER WITH INTEGRAL ADHESIVE CHANNEL AND METHOD - An attachment member including an integral adhesive channel and a method of adhering an attachment member to a substrate includes adhering the member to the substrate using a first adhesive attached to the member to form a gap between the substrate and a bonding surface of the member defined by a perimeter edge. The first adhesive may be a pressure sensitive adhesive. The member defines a channel including a first opening configured to receive a second adhesive, which may be a flowable adhesive. The channel includes a second opening in fluid communication with the bonding surface. After adhering the member to the substrate with the first adhesive, the flowable adhesive is dispensed through the channel and into the gap such that the dispensed flowable adhesive is contained in the gap within the perimeter edge of the bonding surface. The flowable adhesive forms a bond between the substrate and the member.
|CROSSLINKABLE COMPOSITIONS BASED ON ORGANYLOXYSILANE-TERMINATED POLYMERS - Moisture curable silicone adhesives used for sealing joints and for the bonding of substrates such as PVC, concrete, mineral substrates, metals, glass, ceramic, wood, or painted surfaces are prepared from crosslinkable compositions containing both hydrophilic and hydrophobic fumed silicas in a mass ratio of 1:10 to 10:1.
|METHODS FOR PROTECTING AND REPAIRING OF BOAT HULLS - A method for protecting a boat hull is provided. A first polymer thermal spray coating is applied to a surface of a boat hull and to a rigid member. The rigid member is placed at a desired location on the surface of the boat hull. The rigid member is heated such that the first polymer thermal spray coating adhesively bonds the rigid member to the surface of the boat hull.
|SEMICONDUCTOR DEVICE PRODUCING METHOD, SEMICONDUCTOR DEVICE PRODUCING APPARATUS AND PIN - A semiconductor device producing method includes: vacuum-adsorbing a printed substrate on a vacuum adsorption surface of a stage with the printed substrate being pressed on the vacuum adsorption surface; temporarily fixing the printed substrate on the stage by commonly inserting a pin to a through hole formed in the printed substrate and a hole formed in the stage; and releasing the vacuum adsorption.
|METHOD FOR PRODUCING AN ARRAY FOR DETECTING ELECTROMAGNETIC RADIATION, ESPECIALLY INFRARED RADIATION - This method for producing an array for detecting electromagnetic radiation comprises a plurality of elementary detection modules
|METHOD FOR MAKING AN ARM FOR A HINGED STRUCTURE SUCH AS A ROCKER ARM FOR AN AIRCRAFT LANDING-GEAR STRUCTURE - The invention relates to a method for making an arm for a hinged structure such as an aircraft landing gear structure, this arm comprising a main body (
|DUAL LAYER PIPE - A corrugated steel pipe with a dual layer, and more particularly, to a corrugated steel pipe with a dual layer, which can dispose a smooth-walled plastic pipe in a corrugated steel pipe more conveniently, thereby providing a simple construction and conveniently assembling corrugated steel pipes while simultaneously improving a coupling force and a sealing force.
|Method for Establishing an Adhesive Connection Between at Least Two Components, in Particular Vehicle Body Components, by Use of Positive-Fit Elements - A vehicle body construction method is provided for connecting two components which are to be rigidly connected to one another. A first component is provided on which a first positive-fit element projects away from the first component. A second component is provided, which includes a second positive-fit element which cooperates with the first positive-fit element of the first component. The two components are detachably fixed by placing them against one another such that the positive-fit elements mesh with or latchingly engage one another. The components are held relative to one another at least in one direction and are permanently connected by use of an adhesive that is located between mutually facing surfaces of the two components.
|PEELABLE ADHESIVE COMPOSITION - The invention relates to an adhesive composition comprising at least one natural latex and at least one polymeric composition having a glass transition temperature ranging from −50° C. to 0° C.
|THIN FILM COMPOSITE MEMBRANES AND THEIR METHOD OF PREPARATION AND USE - The present invention is a technique to fabricate thin-film composite perm-selective membranes by a transfer method. The composite membranes are useful in separating liquid, vapor or gaseous mixtures by selective permeation and reduce mass transfer resistance of the support layer. Selectivity and flux are improved by reduction of the mass transfer resistance of the support layer.
|PEELABLE ADHESIVE COMPOSITION - The invention relates to an adhesive composition comprising at least one natural latex and at least one polymeric composition having a glass transition temperature ranging from −50° C. to 0° C.
|PROCESS FOR PRODUCING FIBER-REINFORCED FLAT SEMIFINISHED PRODUCTS WITH A POLYAMIDE MATRIX - The invention relates to a process for producing fiber-reinforced flat semifinished products (
|METHOD AND APPARATUS FOR ASSEMBLING A ROTOR BLADE FOR A WIND TURBINE - Method for assembling a rotor blade for a wind turbine, wherein the rotor blade has a first half shell, a second half shell and at least one shear web running in the longitudinal direction of the rotor blade.
|INFUSION BOLT, METHOD OF USE AND METHOD OF MANUFACTURE - Various embodiments include an infusion bolt and methods of manufacturing such a bolt. In one embodiment an infusion bolt includes: a head having an axially accessible opening extending therethrough; and a shaft extending from the head, the shaft having: an inner cavity fluidly connected with the axially accessible opening of the head; a radially outer surface surrounding the inner cavity; and a set of axially extending apertures along the radially outer surface, the set of axially extending apertures fluidly connected with the inner cavity and the axially accessible opening in the head.
|SYSTEMS AND METHODS FOR ASSEMBLING CONFORMAL ARRAYS - Systems and methods according to the present disclosure for assembling conformal arrays utilize an outer tool for insertion into an open cell of a conformal array, an inner tool for insertion into the outer tool, and an adhesive source for delivering adhesive to the edges of the open cell via the inner tool and the outer tool. An assembled conformal array includes adhesive extending along the edges of the open cell.
|APPARATUS OF ENCAPSULATING DISPLAY PANEL AND METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY DEVICE USING THE SAME - An encapsulation apparatus capable of securely sealing a gap of a display panel and improving intensity of the display panel, and a method of manufacturing an organic light emitting display device using the encapsulation apparatus are taught. The encapsulation apparatus includes an injection port having tapered projecting edges formed in both sides of one end the injection port, and injecting a reinforcing material into a gap of a display panel in a dual surface contact manner, the first substrate and the second substrate being attached to each other using a sealant; and a supporter coupled to the injection port and supporting the injection port.
|POLARIZING PLATE, METHOD FOR FABRICATING SAME, AND IMAGE DISPLAY APPARATUS USING SAME - Provided are a polarizer, a manufacturing method thereof, and an image display device employing the same. The polarizer includes a polarization element, a first adhesive layer formed on one side of the polarization element, a second adhesive layer formed on the other side of the polarization element, a protective film attached to the first adhesive layer, and an adhesion layer formed under the second adhesive layer.
|Hydrolytically Stable, Hydrophilic Adhesion-Promoting Monomers and Polymers Made Therefrom - Disclosed are compositions that comprise vinylarylalkylene ethers of cyclodextrins optionally containing ether-linked adhesion-promoting groups, in combination with copolymerizable monomer or monomers. The copolymerizable monomer or monomers may include vinylarylalkylene ethers of oligohydroxy compounds (for example, sorbitol divinylbenzyl ether and others). The composition further may include stabilizers (for example, 1,3,5-trimethyl-2,4,6-tris(3,5-di-(tert)-butyl-4-hydroxybenzyl)benzene and others), and polymerization initiators (for example, phenylbis[2,4,6-trimethylbenzoyl]phosphine oxide and others) and reinforcing materials (for example, imogolite). Methods of preparing the compositions as well as the components of compositions and methods for their use in dental and other applications are also disclosed.
|METHOD FOR MANUFACTURING A PORTABLE ELECTRONIC DEVICE HOUSING - A method for forming a housing for an electronic device (
Patent applications in class By applying after assembly an adhesive, solvent or chemical activating agent


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Despite 'good visit' with Kaepernick, Seahawks may not be done in search for backup QB
So what next for the Seahawks and their pursuit of a backup quarterback, and especially the man in that group who has drawn the most attention, Colin Kaepernick?
Apparently, at least a little bit of a waiting game.
While reports surfaced Thursday that Kaepernick had a good visit and told the team he wants to become a Seahawk, such as one from ...Read more
Dolphins TE Julius Thomas uses his football IQ to gain an edge
DAVIE, Fla. -- If the Miami Dolphins get the Julius Thomas they think they're getting, he could be the best tight end they've had in years -- better than Charles Clay, Dion Sims, Jordan Cameron, Anthony Fasano, the brief and injury-shortened stay of Dustin Keller, and perhaps even Randy McMichael.
The reason for that thinking goes beyond Thomas...Read more
Raiders' Amari Cooper hopes to remedy second-half fades
ALAMEDA, Calif. -- Amari Cooper knows what you're thinking, and he doesn't necessarily disagree.
One of only three receivers in NFL history to record at least 70 receptions and 1,000 yards in each of his first two seasons (the others were Marques Colston and Odell Beckham Jr.), Cooper has nonetheless ended both the 2015 and the 2016 seasons ...Read more
Spencer Ware in unfamiliar but welcome position in Chiefs backfield
For the first time since high school, Chiefs running back Spencer Ware returns as his team's leading rusher.
He's ready for all that comes with that.
"It's a lot of responsibility as far as showing leadership on the field," Ware said Wednesday following the Chiefs' organized team activities. "No pressure, though. I go out every day and work ...Read more
Vikings' Michael Floyd back in his comfort zone
Back home in Minnesota and legally cleared to practice with the Vikings, wide receiver Michael Floyd spent the past two days of organized team activities playing catch-up.
On Wednesday, the first OTA open to media this spring, Floyd worked alongside rookies and other backups while Stefon Diggs, Adam Thielen and Laquon Treadwell hogged the snaps...Read more
Cowboys quarterback Dak Prescott moving at faster, quicker pace
FRISCO, Texas -- It will be several months before it is truly known if Dallas Cowboys quarterback Dak Prescott can improve on what was the best season of any rookie quarterback in NFL history.
But it won't be because of a lack of effort, work ethic or desire.
In those areas, Prescott is already a better player and a better quarterback.
...Read more
Seahawks bring Colin Kaepernick, Austin Davis for visits Wednesday
In their escalating search for a veteran backup quarterback, the Seahawks on Wednesday brought in Colin Kaepernick and Austin Davis for visits, the Seattle Times confirmed.
The visits, though, don't mean a signing is necessarily immediately in the offing. Indications instead are that the Seahawks will use the visits to gather information -- ...Read more
Raiders' Marshawn Lynch 'really soaking up the system' at OTAs
ALAMEDA, Calif. -- For much of Tuesday's OTA practice, Raiders running back Marshawn Lynch stood off to the side of the action, talking with teammates and coaches.
Lynch wore his white No. 24 jersey over a long-sleeved black shirt and his dreadlocks spilled over his shoulders as he did not even carry a helmet.
The veteran running back, who ...Read more
Miles LassiterMargo Lee Williams
Margo Williams had only a handful of stories and a few names her mother remembered from her childhood about her family's home n Asheboro, NC. Her research would soon help her to make contact with long lost relatives and a pilgrimage "home" with her mother in 1982. This story follows her ...
Blindsided by trade, Osweiler determined to become Browns' starting QB
BEREA, Ohio -- Brock Osweiler was in a trap as the brutal business of the NFL ambushed him.
The 6-foot-7, 240-pound quarterback was golfing March 9 in Arizona when he learned the Houston Texans had traded him the Browns.
"I was standing in a sand trap, and I got a phone call and here we come," Osweiler said Wednesday after the second practice ...Read more
Jim Caldwell: Lions concerned about Calvin Johnson's unhappiness
Detroit Lions coach Jim Caldwell said Wednesday the entire organization, from owner Martha Ford on down, is concerned about comments Calvin Johnson made recently about his unhappiness with the way he was treated after he retired.
"I think all of us within the organization, top to bottom, Mrs. Ford down through Bob (Quinn) and the Ford children,...Read more
Cowboys' Elliott to miss workouts after getting injured in car accident
FRISCO, Texas -- Dallas Cowboys running back Ezekiel Elliott will be held out of some organized team activities after being injured in a car accident.
Elliott, the NFL's rookie of the year and a Pro Bowler last season, suffered a bump on his head while a passenger in a car involved in an accident earlier this week. No more details were ...Read more
Super Bowl in Los Angeles is delayed a year; Inglewood will host in 2022
CHICAGO -- Call it the Super Bowl Reshuffle.
Five days after the Los Angeles Rams announced their Inglewood stadium would be finished in 2020, a year later than the original plan, NFL owners unanimously voted to push the Los Angeles Super Bowl back a year until February 2022.
Tampa, Fla., will host the 2021 game originally promised to L.A. -- ...Read more
Marshawn Lynch easing in to Raiders system at OTAs
ALAMEDA, Calif. -- Marshawn Lynch spent most of his first public practice with the Raiders Tuesday engaging with teammates and coaches, flashing his ever-present smile and appearing to enjoy the concept of playing for his hometown team.
Lynch talked and laughed with left tackle Donald Penn and place kicker Sebastian Janikowski during warmups. ...Read more
Alex Smith clarifies comment about Chiefs being committed to him 'through this year'
Chiefs quarterback Alex Smith on Tuesday clarified something he said last week, about the team being committed to him for only this season.
Smith has two years left on his contract, but last month the Chiefs selected a quarterback, Patrick Mahomes of Texas Tech, in the first round of the NFL draft for the first time since 1983.
Does Smith ...Read more
What was Calvin Johnson doing at the Raiders practice?
ALAMEDA, Calif. -- No, he's not coming out of retirement to join the Raiders.
Former Detroit Lions great Calvin Johnson, a six-time Pro Bowl wide receiver, is merely serving as a guest of offensive coordinator Todd Downing for this week of the Raiders' organized team activities.
"He's obviously a big good-looking guy," Raiders coach Jack Del ...Read more
Ben Roethlisberger only committed to playing in 2017
Steelers quarterback Ben Roethlisberger has three years and $46 million remaining on the five-year contract he signed in 2015, but he said Tuesday he did not give team president Art Rooney II a commitment beyond the 2017 season when he informed him last month that he would return for his 14th NFL season.
"I never commit to anyone more than one ...Read more
Steelers' Bryant: 'I changed my whole life around'
Martavis Bryant walked off the Steelers practice field for the first time in 16 months, 10 pounds heavier yet looking and sounding as if the weight of the world was off his shoulders.
"I changed my whole life around compared to how I used to be," he said.
Of course, the gifted wide receiver made promises before, to Ben Roethlisberger and other...Read more
Seahawks legend Cortez Kennedy dead at 48
Cortez Kennedy, one of three Seahawks to have his number retired and one of four to make it to the Pro Football Hall of Fame after playing his entire career in Seattle, has died at the age of 48.
Sgt. Wanda Miglio of the Orlando (Fla.) Police Department confirmed that Kennedy was found dead of still unknown causes Tuesday morning, stating via ...Read more
Los Angeles Chargers edge rusher Melvin Ingram is 'still doing his negotiating thing'
Los Angeles Chargers defensive tackle Brandon Mebane, a belly-rolling, lineman-battling 311-pounder, felt good about his team after its first day of organized team activities last week.
He saw Joey Bosa, the league's reigning rookie of the year, position himself down the line. Denzel Perryman, Jatavis Brown and Kyle Emanuel, the team's trio of ...Read more
Rams' Aaron Donald misses first day of organized team activities because of contract situation
LOS ANGELES -- Aaron Donald deserves a raise, Los Angeles Rams general manager Les Snead said a few months ago.
Now Donald, a three-time Pro Bowl defensive tackle, apparently is taking a stand until he gets one.
Donald was absent from the first day of organized team activities Monday because of his contract situation.
"We were aware he wasn't...Read more
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Skip Johnson, the Goodsells, Mich., bass angler who won the recent FLW Tour event on Kentucky Lake out of Tennessee's Paris Landing State Park, said he claimed the $100,000 victory by not moving.
That's relatively speaking, of course. Johnson was virtually nailed down in comparison to many competitors in the pro bass shoot-out. That is, he fished a single area for all four days of competition, while many others frequently motored from area to area, often miles between fishing locations.
Johnson, indeed, fished several spots along an inundated creek channel as it snaked its way to a juncture with the old Tennessee River channel well south of Paris Landing. But his chosen spots weren't scattered all over creation. They were high-odds contact points along the ledges of the single creek that he had marked with the global positioning system of his depth-finder/sonar.
Moving by trolling motor from spot to spot among more than a dozen waypoints along the stretch of creek, Johnson scratched together and regularly upgraded four five-bass limits over the four days. He brought in limits of 22-0, 22-14, 19-12 (his "bad" day) and 24-0. Together they totaled a winning 88 pounds, 10 ounces.
Johnson weighed in his best five fish each day, of course, but he caught many more fish of "keeper" and better status that didn't make the grade. During the final day alone, Johnson picked over his creek channel haunts to catch more than 75 bass, culling through them to end up with five weighing 24 pounds even.
Most of the places the winner caught fish were rocky creek channel edges of 10-12 feet deep where the underwater bank broke away down to about 15 feet.
Johnson caught many of his winning fish on a jig and trailer, but during the final round the lure that cemented his victory with a 24-pound limit was a Texas-rigged plastic worm, an eight-inch Western Plastics wiggler in crawdad color.
Johnson averaged slightly more than 4.4 pounds in the 20 bass that carried him to the win. And Kentucky Lake proved generous to all the upper finishers in the pro field. Twenty-bass catches (limits for each of four days) averaging more than 4 pounds per fish went to the top nine places.
Trailing Johnson closely were Jason Lambert of Pickwick Dam, Tenn., runner-up with 87 pounds, 8 ounces, and Jim Moynagh of Carver, Minn., third with 86-13. Randy Haynes of Counce, Tenn., was fourth with 85-11 â " and that came about a month after Haynes had won the earlier Rayovac FLW Series Central Series tournament on Kentucky Lake with 75-5 in three days, averaging more than 5 pounds per fish.
n Public safety officials are reminding boaters to navigate with care this holiday weekend, which is typically the busiest period for recreational mariners all year long.
Waterborne enforcement officers â " those of the Department of Fish and Wildlife Resources and the U.S. Coast Guard in particular â " are out in force for the long Fourth of July weekend to keep an eye out for infracting operators and the potential of accidents that come with heavy traffic on the lakes and rivers.
With July 4 falling on Friday, officials anticipated a concentration of water recreation during the three-day, Friday-Sunday holiday stretch. The holiday weekend and the popularity of on-the-water play then is a major part of why July was the leading month for boating accidents in 2013, according to U.S. Coast Guard statistics.
Officers patrolling the waters this weekend will have their eyes peeled for signs of risky boat operations, particularly those that might point to intoxication at the helm. Indeed, enforcers are quick to prosecute imbibing skippers for BUI, boating under the influence, to further the cause of safety on the lakes and rivers.
Boating officers also will be checking those among the fun-time flotillas for required safety equipment aboard boats. Special attention is paid to the requirement to have a life jacket aboard for each boat passenger â " and for children under 12 to be wearing a life jacket when a boat is underway.
n With July in progress, hunters now can apply for quota deer hunts in the Land Between the Lakes this fall. Permits for firearms hunts can be sought by signing in for a computer lottery at www.lbl.org (under "See and do") or by telephone at 270-924-2065.
Applications must be made by July 31. The fee to apply is $5 online or $7 by phone.
In the Kentucky part of the LBL, a quota youth hunt will be Oct. 25-26 and a regular quota hunt will be Nov. 23. In the Tennessee portion of the federal area, a youth hunt will be Oct. 18-19 and regular hunts are set for Nov. 14-15 and Nov. 22-23.
Steve Vantreese is a freelance outdoors writer. E-mail outdoors news to email@example.com or phone 270-575-8650.
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According to Professor CHARLES GRAY SHAW, soft collars and soft hats threaten to awaken "the slumbering other sex" of men -- to effeminize them as effectually as the boyishly bobbed flapper is masculinized. Advices from London indicate that English tailors and cloth makers are collaborating to this abhorrent end.
April 14, 1925
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