text:
Patricia Kane, PhD
Chair and Professor
The central goals of scientists in the Biochemistry and Molecular Biology department are to research fundamental mechanisms in cells and organisms at the molecular level and to train the next generation of scientists. Read More...
Faculty Research Interests
Andras Perl, MD, PhD
766 Irving Ave.
Syracuse, NY 13210
315 464-3836
Current Appointments
- Professor of Medicine
- Professor of Biochemistry and Molecular Biology
- Professor of Microbiology and Immunology
- Division Chief of Rheumatology
- Co-Director, MD/PhD Program
Hospital Campus
- Downtown
Clinical Section Affiliations
- Medicine: Rheumatology
Research Programs and Affiliations
- Biochemistry and Molecular Biology
- Biomedical Sciences Program
- Medicine
- Microbiology and Immunology
- Rheumatology Clinic
Upstate Health Care Center
Google Maps & Directions
2nd Floor, Firm C, 90 Presidential Plaza
Syracuse, NY 13202
315 464-3836
Education & Fellowships
- Fellowship: University of Rochester Medical Center, 1988, Rheumatology/Immunology
- PhD: Semmelweis Medical University, Budapest, Hungary, 1984
- Residency: Semmelweis Medical School, Budapest, 1982
- MD: Semmelweis Medical University, Budapest, Hungary, 1979
Clinical Interests
Arthritis, Rheumatic Diseases, Autoimmune Diseases, Systemic Lupus Erythematosus, Transaldolase Deficiency
Education Interests
Rheumatology, Immunology, Physician-Scientist Training
Research Interests
Genes and Viruses Predisposing to Autoimmunity, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase
Clinical Trials
- A Phase II Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-range Finding
Study to Evaluate the Safety and Efficacy of ALX-0061 Administered Subcutaneously in Subjects with
Moderate to Severe Active Systemic Lupus Erythematosus
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- Molecular Biology and Pathology of Transaldolase
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- ROLE of HTLVS and related endogenous sequences in autoimmune diseases and human cancers
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Specialties & Certification
- Rheumatology
- Internal Medicine
Diseases & Conditions Treated
- Arthritis
- Autoimmune Disease
- Immune Abnormalities
- Nervous System Vascular Lesions
- Osteoarthritis
- Polymyalgia Rheumatica (PMR)
- Rheumatoid Arthritis
- Scleroderma
- Systemic Lupus Erythematosis (SLE)
- Tendonitis
- Tennis Elbow
- Transverse myelitis
- Adults
- Joint Aspiration
- American Association for the Advancement of Science (AAAS)
- Henry Kunkel Society
- Federation of Clinical Immunology Societies Center of Excellence, Director
- American Association of Immunologists (AAI)
- American Society for Biochemistry and Molecular Biology (ASBMB)
- American College of Rheumatology (ACR), Fellow
- American Association for the Study of Liver Diseases (AASLD)
Current Hospital Privileges
- Upstate University Hospital
HealthLink on Air Radio Interview
Link to PubMed (Opens new window. Close the PubMed window to return to this page.)
Specific areas of research in the laboratory
Molecular biology of autoantigens:
I. Expression of Human Endogenous Retroviral Sequences (ERS). ERSs and other retrotransposable elements are a major factor in shaping, reorganization, and evolution of the eukaryotic genome. The notion, that aberrant structure, expression or recognition of ERS is involved in the pathogenesis of autoimmunity, could explain both the familial aggregation and detection of cross-reactive anti-retroviral autoantibodies in patients with autoimmune diseases. HRES-1, an endogenous retroviral element that has entered the human genome at the developmental stage of old world primates, has been cloned in this laboratory. The HRES-1 genomic locus has been mapped to a common fragile site on the long arm of human chromosome 1. It is transcriptionally active, and contains two open reading frames. In contrast to most nuclear aut oantigens which are ubiquitously present in every nucleated human cell, HRES-1/p28 is expressed in a tissue-specific manner (Proc. Natl. Acad. Sci. USA, 89:1939-1943, 1992). Antibodies to HRES-1/p28 are detectable in patients with systemic lupus erythematosus and overlap syndromes (Arth. Rheum. 38:1660-1671, 1995). Future studies on HRES-1 will 1) determine the role of genetic variations of the HRES-1 gene locus in autoimmune diseases, 2) delineate the molecular basis of its tissue-specific expression 4) assess HRES-1 autoantibody levels and expression in association with disease activity.
II. Molecular Biology of Transaldolase (TAL) and an Associated Retrotransposable Element (TARE)
A novel retrotransposable element was cloned based on a limited sequence homology to the endogenous retroviral sequence, HRES-1. This repetitive element was found to constitute exons 2 and 3 of the coding sequence of a 38 k D autoantigen which corresponds to the human transaldolase (TAL-H) enzyme. Detection of a retrotransposon, TARE (transaldolase-associated retrotransposable element), in the coding sequence of a human gene demon strates the importance of these repetitive elements in evolution of the eukaryotic genome. Ongoing studies are focused on mobility of TARE and its role in transcriptional regulation of the TAL-H gene. TAL is a key enzyme in the nonoxidative phase of the pen tose phosphate pathway (PPP) which fulfills two essential functions, formation of ribose 5-phosphate for synthesis of nucleotides, RNA, and DNA and generation of NADPH for biosynthetic reactions and to maintain glutathione at a reduced state, thus, to protect sufhydryl groups and cellular integrity from oxygen radicals. Importance of PPP in general, and of TAL in particular, have been demonstrated in numerous processes involving programmed cell death (PCD), e.g. host defence mechanisms against oxidative stress, inflammation, lymphocyte activation, phagocytosis, embryogenesis, myelination, and extreme sensitivity of oligodendrocytes to PCD. The role of TAL-H in PCD is curre ntly being evaluted by gene transfection studies. Molecular biology and autoantigenicity of TAL is particularly significant in patients with multiple sclerosis (MS). MS is caused by demyelination secondary to a selective loss of oligodendrocytes by immune-mediated PCD. Molecular mimicry between viral core proteins and the TARE-encoded segment of TAL-H may play a role in breaking immunological tolerance and leading to a selective destruction of oligodendrocytes in MS.
Three-dimensional model of human transaldolase (TAL-H) displayed with the Molscript program (40 ). TAL-H forms an ß barrel, 14 helices represented by spirals) around 8 ß sheets (represented by wide flat arrows). The catalytic site with the Schiff base-forming Lys142 (K142) is on strand ß4. The first and last residues (M1, K337), K142, the polar/charged residues of peptide 24 (R239, N240, K245) and peptide 28 (K277, Q280, D283), and the starting residue (Q265) of an immunodominant loop between residues 265 and 290 are shown as landmarks. Circles show the orientation of nitrogen (blue circles), oxygen (red) and carbon atoms (gray circles) of topographically exposed and charged amino acids. From Esposito et al., M., Venkatesh, V., Otvos, L., Weng, Z., Vajda, S., Banki, K. and Perl, A. (1999) Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients. J. Immunol. 163:4027-4032.
III. Impact of TAL on redox control of apoptosis
Apoptosis is a fundamental form of programmed cell death (PCD) which is indispensable for normal development and maintenance of homeostasis within multicellular organisms. Defects in apoptosis may underlie the etiology of n eurodegenerative diseases, cancer, autoimmune diseases, and the acquired immune deficiency syndrome (AIDS). In particular, apoptosis is blocked at various levels in cancer cells. By contrast, increas ed apoptosis underlies the etiology of T cell depletion in AIDS. Reactive oxygen intermediates (ROIs) have long been considered as toxic by-products of aerobic existence, but evidence is now accumulating that controlled levels of ROIs modulate cellular function and are necessary for signal-transduction pathways, including those mediating apoptosis. Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose phosphate pathway (PPP) which is responsible for generation of NADPH to maintain glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from ROIs. To evaluate the role of TAL in this process, Jurkat and H9 human T cells were permanently transf ected with TAL expression vectors oriented in the sense or antisense direction. Overexpression of TAL resulted in a decrease in G6PD and 6PGD activities and NADPH and GSH levels and rendered these cells highly susceptible to apoptosis induced by serum deprivation, hydrogen peroxide, nitric oxide, tumor necrosis factor (TNF), anti-Fas monoclonal antibody or infection by HIV-1. In addition, reduced levels of TAL resulted in increased G6PD and 6PGD activities and in creased GSH levels with inhibition of apoptosis in all systems. Our results provide definitive evidence that TAL has a role in regulating the balance between the two branches of PPP and its overall output as measured by GSH production and thus influences sensitivity to cell death signals. The effect of TAL expression on susceptibility to apoptosis through regulating the PPP and GSH production is consistent with an involvement of ROIs in each pathway tested. Currect efforts are directed towards TAL-mediated regulation of metabolism and specific cell death programs.
IV. Mitochonrial hyperpolarization (MHP) is an early and reversible event in T cell activation and apoptosis
Disruption of the mitochondrial transmembrane potential (MTP) has been proposed as the point of no return in apoptotic signaling. MTP is dependent upon the electron transport chain transferring electrons from NADH to molecular oxygen and proton transport mediated by the F0/F1 -ATPase complex. The energy stored in the electrochemical gradient is utilized by F0/F1 -ATPase to convert ADP to ATP during oxidative phosphorylation. We have discovered that elevation of MTP or MHP occurs in the early phase of Fas-induced apoptosis of Jurkat human leukemia T cells and normal human PBL. MHP precedes phosphatidyl serine (PS) externalization and disruption of MTP in Fas- and H2O2 -induced apoptosis. These observations were confirmed and extended to p53, TNF, and staurosporin-induced apoptosis by other laboratories. Elevation of MTP is independent from activation of caspases and represents an early event in apoptosis. With MHP and extrusion of H+ ions from the mitochondrial matrix, the cytochromes within the electron transport chain become more reduced which favors generation of ROI. ROIs can modify signaling initiated via the CD3/CD28 receptors. Moreover, T cell activation via CD3/CD28 receptors induces mitochondrial hyperpolarization and ROI production in normal PBL. Recent data from our laboratory suggest that T cell activation-induced MHP is mediated by Ca2+- and redox-dependent production of nitric oxide.
V. Activation and Cell Death Signaling in Systemic Lupus Erythematosus
We have discovered that lymphocytes from patients with SLE exhibit mitochondrial hyperpolarization, leading to abnormal activation and cell death signaling. Mitochodnrial hyperpolarization (MHP) leads increased production of reactive oxygen intermediates, cytoplasmic alkalinization, and ATP depletion which in turn predisposes to necrosis in response to activation and cell death signals. Understanding the molecular basis of MHP may lead to novel therapies in patients with SLE.
Selected references:
Perl, A., J.D. Rosenblatt, I.S.Y. Chen, J.P. DiVincenzo, R. Bever , B.J. Poiesz, and G.N. Abraham (1989) Detection and cloning of new HTLV-related sequences in man. Nucleic Acids Res.17, 6841-6854.
Banki, K., J.S. Maceda, E. Hurley, E. Ablonczy, D. Mattson, L. Szegedy, C. Hung and A. Perl (1992) HRES-1, a human endogenous retroviral sequence encodes a 28 kd protein: a possible autoantigen for HTLV gag-reactive autoantibodies. Proc. Natl. Acad. Sci. USA, 89, 1939-1943.
Krieg, A.M., Gourley, M.F. and Perl, A. (1992) Endogenous retroviruses: Potential etiologic: agents in autoimmunity. FASEB J. 6:2537-2544.
Perl, A. and Banki, K. (1993) Human endogenous retroviral elements and autoimmunity: data and concepts. Trends Microbiol. 1:153-156.
Banki, K., Halladay, D. and Perl, A. (1994) Cloning and Expression of the Human Gene for Transaldolase: a Novel Highly Repetitive Element Constitutes an Integral Part of the Coding Sequence. J. Biol. Chem. 269:2847-2851.
Banki, K., E. Colombo, F. Sia, D. Halladay, D. H. Mattson, A.H. Tatum, P. T. Massa, P. E. Phillips, Perl, A. (1994) Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J. Exp. Med. 180:1649-1663.
Perl, A., Colombo, E., Dai, H., Agarwal, R.K., Mark, K., Banki, K., Poiesz, B.J., Phillips, P.E., Hoch, S.O., Reveille, J.D. and Arnett, F.C. (1995). Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes: Correlation with antinuclear antibodies and HLA class II alleles. Arth. Rheum. 38: 1660-1671.
Banki, K., Hutter, E., Colombo, E., Gonchoroff, N.J. and Perl, A. (1996) Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression. J. Biol. Chem.. 271: 32994-33001.
Banki, K., Eddy, R.L., Shows, T.B., Halladay, D.L., Bullrich, F., Croce, C.M., Jurecic, V., Baldini, A. and Perl, A. (1997) The human transaldolase gene is located on chromosome 11 at p15.4 -p15.5. Genomics, 45: 233-238.
Colombo, E., Banki, K., Tatum, A.H., Daucher, J., Ferrante, P., Murray, R.S., Phillips, P.E. and Perl, A. (1997) Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J. Clin. Invest. 99:1238-1250.
Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A. (1998) Molecular ordering in HIV-induced apoptosis: oxidative stress, activation of caspases and cell survival are regulated by transaldolase. J. Biol. Chem. 273:11944-11953.
Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A.(1999) Elevation of mitochondrial transmembrane potential and ROI levels are early even ts and independent from activation of caspases in Fas signaling. J. Immunol. 162:1466-1479.
Magistrelli, C., Samoilova, E., Agarwal, R.K., Banki, K., Ferrante, P., Vladutiu, A., Phillips, P.E. and Perl, A. (1999) Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus are associated with systemic lupus erythematosus and autoreactivity. Immunogenetics, 49:829-834.
Esposito, M., Venkatesh, V., Otvos, L., Weng, Z., Vajda, S., Banki, K. and Perl, A. (1999) Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients. J. Immunol. 163:4027-4032.
Perl, A. (1999) Mechanisms of viral pathogenesis in rheumatic diseases. Ann. Rheum. Dis. 58:454-461.
Perl, A., Colombo, E., Samoilova, E., Butler, M.C. and Banki. K. (2000) Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. J. Biol. Chem. 275:7261-7272.
Puskas, F., Gergely, P. Jr., Banki, K. and Perl. A (2000) Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J. 14:1352-1361.
Perl, A. and Banki, K. (2000) Genetic and Metabolic Control of the Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Production in HIV disease. Antioxid. Redox Signal. 2:551-573.
Perl, A. (2001) Endogenous Retroviruses in the Pathogenesis of Autoimmunity. Editorial. J. Rheumatol. 28:461-464.
Lachaise, F., Martin, G., Drougard, C., Perl, A, Vuillaume, M., Wegnez, M., Sarasin, A., Daya-Grosjean, L. (2001) Relationship between post-translational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient Xeroderma pigmentosum fibroblasts and SV40-transformed human cells. Free Rad. Biol. Med. 30:1365-1373.
Perl, A. (2001) Abnormal Apoptosis in Systemic Lupus. Lupus News, 21:16-17.
Gergely, P. Jr., Grossman, C. , Niland, B. , Puskas, F. , Neupane, H. , Allam, F. , Banki, K. , Phillips, P.E. and Perl, A. (2002) Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arth. Rheum. 46:175-190.
Puskas, F., Gergely, P., Niland, B., Banki, K. and Perl, A. (2002) Differential regulation of hydrogen peroxide and Fas-dependent apoptosis pathways by dehydroascorbate, the oxidized form of vitamin C. Antiox. Redox Signal. 4:357-369.
Perl, A, Gergely, P., Puskas, F. and Banki, K. (2002) Metabolic switches of T cell activation and apoptosis. Antiox. Redox Signal. 4:427-443.
Gergely, P. Jr., Niland, B., Gonchoroff, N., Pullmann, R. Jr., Phillips, P.E. and Perl, A. (2002) Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasm ic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus. J. Immunol. 169:1092-1101.
Nagy, Gy, Koncz, A. and Perl A (2003) T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J. Immunol. 171: 5188-5197.
Grossman, C.E., Qian, Y., Banki, K. and Perl, A. (2004) ZNF143 mediates basal and tissue-specific expression of human transaldolase. J. Biol. Chem. 279: 12190-12205.
Perl,A.; Gergely,P.,Jr.; Banki,K. (2004) Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus. Int. Rev. Immunol. 23:293-313.
Grossman, C. E., Niland, B., Stancato, C, Verhoeven, N.M., van der Knaap, M.S., Jakobs, C., Brown, L.M., Vajda, S., Banki, K. and Perl, A. (2004) Deletion of serine 171 causes inactivation, proteasome-mediated degradation and complete deficiency of human transaldolase. Biochem. J. 382:725-231.
Nagy, Gy, Barcza. M., Gonchoroff, N., Phillips, P.E. and Perl, A. (2004) Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells. J. Immunol. 173:3676-3683.
Nagy, Gy, Koncz, A, Phillips, P.E. and Perl, A. (2005) Mitochondrial signal transduction abnormalities in systemic lupus erythematosus. Curr. Immunol. Rev. 1: 61-67.
Gergely. P. Jr,Pullmann, R., Stancato, C., Otvos, L. Jr, Koncz, A., Blazsek, A., Poor, Gy,Brown, K.E., Phillips, P.E. and Andras Perl. (2005) Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin. Immunol. 116: 124-134.
Nagy, Gy, Koncz, A, and Perl, A. (2005) T- and B-cell abnormalities in systemic lupus erythematosus. Crit. Rev. Immunol. 25: 123-140.
Nagy, Gy, Koncz, A, and Perl, A. (2005) Signal transduction abnormalities in systemic lupus erythematosus (In Hungarian). Orv. Hetil. 146:1625-1630.
Niland, B., Banki, K., Biddison, W.E.and Perl, A. (2005)CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J. Immunol. 175: 8365-8378.
Nagy G.and Perl, A. (2006) The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus. Clin. Immunol. 118: 145-151.
Vas, Gy., Conkrite, K., Amidon, W., Qian, Y., Banki, K., and Perl, A. (2006) Study of transaldolase deficiency in urine samples by LC-MS/MS. J. Mass. Spec. 41: 463-469.
Fernandez, D., Bonilla, E., Mirza, N, Niland, B. and Perl, A. (2006) Rapamycin reduces disease activity and normalizes T-cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arth. Rheum. 54: 2983-2988.
Perl, A., Qian, Y, Chohan, K.R., Shirley, C.R., Amidon, W., Banerjee, S., Middleton, F.A., Conkrite, K.L., Barcza, M., Gonchoroff, N., Suarez, S.S., and Banki, K. (2006) Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa.Proc. Natl. Acad. Sci. USA, 103: 14813-14818.
Nagy, G., Ward, J., Mosser, D.D., Koncz, A., Gergely, P.Jr., Stancato, S., Qian, Y, Fernandez, D., Niland, B., Grossman, C.E., Telarico, T, Banki, K, Perl, A. (2006) Regulation of CD4 expression via recycling by HRES‑1/RAB4 controls susceptibility to HIV infection. J. Biol. Chem. 281: 34574-34591
Fernandez, D., Bonilla, Phillips, P.E. and Perl, A. (2006)Signaling abnormalities in systemic lupus erythematosus as potential drug targets. Endocrin, Metabolic & Immune Disorders - Drug Targets. 6: 305-311.
Gergely, P., Perl, A. and Poor, Gy. (2006) Possible pathogenic nature of the recently discovered TT virus. Does it play a role in autoimmune rheumatic diseases? Autoimmun. Rev. 6:5-9.
LaRocca, D., Lehmann, D.F., Perl, A., Ozawa, T., Holohan, P. D. (2006) The combination of nuclear and mitochondrial mutations as a risk factor for idiosyncratic toxicity. Brit. J. Clin. Pharm. 63:249-251.
Silberstein, M., Landon, M.R., Wang, Y.E., Perl, A. and Vajda, S. (2006) Computational methods for functional site identification suggest a substrate access channel in transaldolase. Genome Inform. 17: 13-22.
Koros, A., Hanczko,R., Jambor, Qian, Y., Perl, A. and Molnar-Perl, I. (2007) Analysis of amino acids and biogenic amines in biological tissues as their o-phthalaldehyde/ethanethiol/fluorenylmethyl chloroformate derivatives by high-performance liquid chromatography: A deproteinization study. J. Chromatogr. A 1149: 46-55.
Nagy, G., Koncz, A., Fernandez, D. and Perl A. (2007). Nitric oxide, mitochondrial hyperpolarization, and T-cell activation. Free Radic. Biol. Med. 42: 1625-1631.
Perl, A. (2007) The pathogenesis of transaldolase deficiency. IUBMB Life 59: 365-373.
Bonilla, E., Francis, L., Allam, F., Ogrinc, M., Neupane, H., Phillips, P.E., and Perl, A. (2007) Immunofluorescence microscopy is superior to fluorescent beads for detection of antinuclear antibody reactivity in systemic lupus erythematosus patients. Clin. Immunol. 124:18-21.
Hanczko, R., Jambor, A., Perl, A., and I Molnar-Perl (2007) Advances in the o-phthalaldehyde derivatizations:Comeback to the o-phthalaldehyde-ethanethiol reagent. J. Chromatogr. A 1163: 25-42.
Pullmann, R. Jr., Bonilla, E., Phillips, P.E., Middleton, F.A. and Perl, A. (2008) Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus. Arth. Rheum. 58: 532-540.
Francis L, Bonilla E, Soforo E, Neupane H, Nakhla H, Fuller C, and Perl A. (2008) Fatal toxic myopathy attributed to propofol, methylprednisolone, and cyclosporine after prior exposure to colchicine and simvastatin. Clin. Rheumatol. 27:129-31.
Perl, A., Nagy, G., Koncz, A., Gergely, P., Fernandez, D., Doherty, E., Telarico, T., Bonilla, E. and Phillips, P.E. (2008) Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE. Autoimmunity, 41:287-297.
Qian, Y., Banerjee, S., Grossman, C.E., Amidon, A., Nagy, Gy., Barcza, M., Niland, B., Karp, D.R., Banki, K., and Perl, A. (2008) Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homeostasis, and apoptosis signal processing. Biochem. J. 415:123-134.
Vyshkina, T., Sylvester, A., Sadiq, S., Bonilla, E., Canter, J., Perl, A. and Kalman, B.(2008) Association of Common Mitochondrial DNA Variants with Multiple Sclerosis and Systemic Lupus Erythematosus. Clin. Immunol. 129:31-35.
Vyshkina, T., Sylvester, A., Sadiq, S., Bonilla, E., Perl, A. and Kalman, B.(2008) CCL genes in multiple sclerosis and systemic lupus erythematosus. J. Neuroimmunol. 200:145-152.
Perl, A. (2009) Overview of Signal Processing by the Immune System in SLE. Autoimmun. Rev. 8:177-178.
Fernandez D.R. and Perl, A. (2009) Metabolic control of T-cell activation and death in SLE. Autoimmun. Rev. 8:184-189.
Fernandez, D.R. Telarico, T., Bonilla, E., Li, Q., Banerjee, S., Middleton, F.A., Phillips, P.E., Crow, M.K., Oess, S., Muller-Esterl, W., and Perl, A. (2009) Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J. Immunol. 182: 2063-2073.
Hanczko, R., Fernandez, D.R., Doherty, E., Qian, Y., Vas, G., Niland, B., Telarico, T., Garba, A., Banerjee, S., Middleton, F.A., Barrett, D., Barcza, M., Banki, K., Landas, S.K. and Perl, A. (2009) Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J. Clin. Invest. 119:1546-1557.
Francis, L. and Perl. A. (2009) Pharmacotherapy of SLE. Expert. Opin. Pharmacother. 10: 1481-1494.
Perl, A., Fernandez, D., Telarico, T., Francis, L. and Phillips, P.E. (2009) T- and B-cell signaling biomarkers and treatment targets in lupus. Curr. Opin. Rheumatol. 21: 454-464.
Perl, A. (2009) Editorial: Emerging New Pathways of Pathogenesis and Targets for Treatment in Systemic Lupus Erythematosus and Sjogren's Syndrome. Curr. Opin. Rheumatol. 21: 443-447.
Bedoya, F., Medveczky, M.M., Lund, T.C., Perl, A., Horvath, J., Jett, S.D. and Medveczky, P.G. (2009) Identification of Mitochondrial Genome Concatamers in AIDS-associated lymphomas and lymphoid cell lines. Leuk. Res. 33:1499-1504.
Tily, HI and Perl, A. (2009) Lymphedema: a paradoxical effect of tumor necrosis factor inhibitors - case report and review of literature. BMJ Case Reports [doi:10.1136/bcr.07.2008.0520]
Blank, M., Shoenfeld, Y. and Perl, A. (2009) Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus. Lupus, 18: 1136-1143.
Soforo, E., Baumgartner, M., Francis, L., Allam, F., Phillips, P.E., and Perl, A. (2010) Induction of systemic lupus erythematosus with TNF blockers. J. Rheumatol. 37:204-205.
Francis, L. and Perl. A. (2010) Infection in systemic lupus erythematosus: friend or foe? Int. J. Clin. Rheumatol. 5:59-74.
Perl, A. (2010) Editorial: Pathogenic Mechanisms in Systemic Lupus Erythematosus. Autoimmunity, 43:1-6.
Perl, A. (2010) Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance and selecting targets for treatment. Autoimmunity 43: 32-47.
Tily, H., Banki, K., Hoffman, G.S. and Perl. A. (2010) Detection of lupus anti-coagulant and successful anti-coagulation in familial Sneddon syndrome. Ann. Rheum. Dis. 69: 775-776.
Niland, B, Miklossy, G, Banki, K, Biddison, W.E., Casciola-Rosen, L., Rosen, A., Martinvalet, D., Lieberman, J., and Perl, A. (2010) Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J. Immunol., 184:4025-32.
Faculty Profile Shortcut: http://www.upstate.edu/faculty/perla


text:
Great info from you answers all my questions. so good to get this feedback makes it easier to decide which one next
Have you ridden one of your mates hellfires. couple of my mates have hellfires love them . Futura or hellfire? decisions. in the meantime absolutely frothing over the elf. im 52 been surfing for 40 years and definitely one of the funnest boards ive owned.Did you ever use pc5 in the elf how did it go.nearly always ride as a thruster pc7 with smaller centre fin sf4 or similar. have tried as a quad with sf4 all round didnt have any drive swapped the fronts for pc7 left sf4 rears that was heaps better.Cheers.

subset: commoncrawl


text:
Town Square
Looking to Make Change in our Community
Original post made by Sabarigirish Somanathan, Amador Valley High School, on Apr 6, 2013
My name is Sabari Somanathan and I am a Sophomore at Amador Valley High School looking to make real change in the Pleasanton community, namely the School District. After reading the Town Square forums along with many other political books about change and reform, I feel like a student who is driven to speak up is what has been missing in this town.
Being a student who is constantly engaged with schoolwork, it is hard to stay updated on what is actually going on within the school district and community. This prevents me from bringing up any real topics for which to pass legislation or bring up debates. For this I ask of the Town Square community to share your ideas with me as to how I may proceed with this task of mine, and what topics I should work towards.
I thank all of you for your time and look forward to hearing from you all.
Sabari Somanathan
Comments (5)
a resident of Another Pleasanton neighborhood
on Apr 6, 2013 at 7:22 am
Sabari - i am glad you came forward asking for help, i am a little dismayed that as a third quarter sophomore with the internet at your finger tips you couldnt research a bit more on your own, qnd im saddened ny the fact that you havent learned these thongs in our schools.
I understand with homework you may not be able to attend these meetings, cut the following would be very benefical for you. You could always DVR them and watch at your convenience. They are:
City council mtg
School board mtg
Planning commisson mtg
you must remember that most of what you find in the forums are opinions, especially in the comment section, and therefore biased. You need to gather all the facts on an issue and form your own opinion.
a resident of Another Pleasanton neighborhood
on Apr 6, 2013 at 7:49 am
The important thing to remember is that taxes are tyranny and tax reductions are freedom. Because when you fix roads or help feed kids with food stamps, you make people dependent on the government. And that's tyranny. But when you give people potholes and empty stomachs, that's freedom. I strongly advice you to look up some of the important TEA Party documents and speeches. I'd begin with early Ku Klux Klan documents, move to John Birch Society, and then jump right into Sarah Palin's most elocuent speeches. And Donald Trump.
a resident of Amador Valley High School
on Apr 6, 2013 at 8:53 am
DJohns is a registered user.
HI Sabari,
You are absolutely correct that the student voice can be very powerful but students are too busy to be active in a meaningful way. It is necessary to get the support of others with shared concerns to be effective. At the schools there are the leadership groups but they are strongly guided by school staff and focus on school activities. The City has the youth commission but they are strongly guided by City staff and are guided away from anything meaningful. Even adults do not know how to navigate the system to be effective, and are rarely committed enough to preserver through the obstacles that are designed to maintain staff preferred status quo.
What are your concerns that you would like to make changes in? There has been a failed 20 year effort to build a community/youth center. Many community members have expressed concern over the continued overcrowding of our schools. There has been outrage over the anti-youth attitude of many Pleasanton merchants and community members who want to ban kids from downtown. There is concern about the limited pro-kid places for kids to gather and the shutdown of the water-slides, an important youth asset. For many years youth have asked the city of Pleasanton for a safe place for the benign activity of air-soft battles but kids are instead the target of Pleasanton's SWAT team. Pleasanton police profile (harass) our youth, an activity that is illegal to do to adults.
Our youth do need representation, I hope you identify something meaningful and follow through on it. I wish you success and would love support your efforts. Feel free to contact me, firstname.lastname@example.com.
a resident of Amador Valley High School
on Apr 6, 2013 at 12:55 pm
Sabarigirish Somanathan is a registered user.
You all have shared some really great ideas and I have made it a priority to attend the City Council and School Board meetings as I believe they will provide the most insight into current affairs regarding the district and school. With this information I hope to prepare arguments either against or for certain proposals and will obtain the consent of my school peers so that I may speak for the youth as a whole. I feel this is a strong plan and will bring about much needed representation. If anyone has any further suggestions or ideas please let me know. My email is email@example.com if anyone wishes to contact me via email.
Thank you all for your support.
a resident of Another Pleasanton neighborhood
on Apr 6, 2013 at 3:41 pm
nancy s. is a registered user.
Also there is a youth commission in pleasanton. You could look into what they do as well.
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text: This is my first post on this forum. I am preparing to get back into (hobby) beekeeping this next spring after 35 year hiatus. My home is on the Mississippi gulf coast. As I read about all the pests that were not a problem the last time I kept bees, there is a lot of talk about screened bottom boards. I envision that the 140 mph winds would create quite a bit of turbulence within the hive that could damage things. What are your experiences with screened bottom boards in hurricanes?


text:
Excenter Rearset Honda CBR 1000 RR from 2008
- Description
A sport rearset made of anodized aluminum without footpegs - please include a color choice in the order.
- perfect adjustment through laser marking - it enables a 15 mm horizontal adjustment and a 30 angle up or down rotary adjustment
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- ultra-light with the greatest stiffness - reduced for the best performance
- used by successful racing teams
- a double-sided heel guard
- individual base plates hard-anodised in black
- completely assembled.
Suitable slip-proof footpegs have to be ordered separately in a color of choice: as stiff footpegs with a slider effect and race approval - 60380405000 and subsequent.
For installation and use of adjustment a new suitable rear brake line (60320701010) is also required.
Eccentric covers in matching colors are available - article 60380405060 and subsequent.
- Shipping & delivery
We always give our best to handle your order as fast as possible. Orders which are placed before 2 pm on a work day are usually handed over to our logistics partner (DHL) on the same day if in stock.
Shipping cost
4.95 Euro within Germany, Poland
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Fragen zum Produkt


text:
By Andy Exley
Within four months in 1996, two events that could hardly be more disparate occurred, yet both paved the way for the making of an icon.
Arsène Wenger joined Arsenal as manager (complete with 'Arsène Who?' headlines in the press) in September of that year and his impact on Arsenal Football Club and the game in general needs no explanation in this magazine. Rewind four months to June of that year and Shawn Corey Carter, also known as Jay-Z, released his debut album Reasonable Doubt to great critical acclaim.
The following 14 years have witnessed remarkable success for both men with the Arsenal manager claiming three league titles, four FA Cups, four Charity Shields and three Manager of the Year awards. Rapper Jay Z has gone on to conquer the music world, selling over 40 million albums worldwide and when his most recent album, The Blueprint 3, reached the top of the Billboard charts in the United States he surpassed Elvis Presley as the solo act with the most number one albums ever.
So we've established the credentials of Mr. Wenger and Mr., urm, Z but why the comparison? Well after rumors have done the rounds over recent weeks about the 40 year-old Hip-Hop star having a liking for Arsène Wenger's Gunners, the Official Magazine managed to receive cast-iron confirmation of the Brooklyn born superstar's support by nabbing 'Mr. Beyonce' for an exclusive interview about his beloved Arsenal.
First things first, and why does a man from Brooklyn who is part-owner of the New Jersey Nets basketball team in the NBA, have an emotional stake in a football team across the Atlantic?
"It was about five years ago now," explains the ten-time Grammy Award winner. "When Thierry Henry was at the club I saw him play and I just thought he was an amazing player, ever since then I have been a big fan of the club, following you guys and still today you play the beautiful football that Thierry did, I think he had a real long term effect on the team.
"I love all sports, but what I really love is when people play sport in a beautiful way, and that's one thing Arsenal do for sure.
"I don't get chance to watch the team in London," he continues, "it's difficult to find time with all the travelling I do, plus I live so far away. But we get all the EPL games over in the States, you can watch any games you like, so it's pretty easy to keep up to date with how Arsenal are doing."
Despite not getting to Emirates Stadium yet, Jay-Z did make his Premier League debut at Eastlands earlier this season, when he saw Manchester City's controversial 4-2 victory over the Gunners. His high-profile presence as a guest of the City hierarchy ¬ he was in Manchester for a concert in the city – led to speculation that the New Yorker harbored loyalties for the Premier League's nouveau riche, a fact he is quick to dispel. "The result wasn't great [at City], but I was glad to see Arsenal play," he says. "After that game the press started reporting that I was a Manchester City fan, I am really glad all that has been cleared up and that everybody in the UK knows that I am an Arsenal fan.
"I will come to Emirates soon that's for sure. I love London as a city, it's just finding time when I am over here for a few days to come and watch a game. I will find time soon, I will make sure of it."
So who would Jay-Z particularly like to see in action when he finally gets to watch a match at Emirates? Not surprisingly, the peerless skipper gets a special mention, whilst the man who originally pricked his interest would also be on the menu, if at all possible.
"I think Cesc Fabregas is a great player," says the rapper who recently topped the singles charts with 'Empire State of Mind'. "It doesn't matter what sport it is the greatest sportsmen in the world do the difficult things and make it look easy. That's what Cesc does, he is so graceful in everything he does, and it looks effortless, the boy was born to play soccer you can see that.
"And Thierry Henry – that is a guy I would like to meet. I know he is a big NBA fan, so I might meet him courtside one day, or maybe when I come to the Emirates. He still comes to watch you guys right? He must do he is a legend there.
"I don't know if there are any fans in the current team," he says modestly, "but if there are they would be more than welcome to come to my next concert when I am over in London. They can come and see me do my work, and then I will come and see them do their work."
Basketball references are frequent with Jay-Z and his love for the sport is matched by so many in the 'Big Apple' but is football finally taking a foothold there?
"Basketball is the sport of New York, and you are never going to change that," he stresses. "Then New Yorkers love their [American] football and baseball, but I think soccer's popularity is growing in the US. It's never going to be the number one sport, but more people are playing it and watching it than ever have before.
"I just love watching people at the top of their game," he continues, "plus when I was growing up basketball was a big part of our life and I used to spend a lot of time playing. It doesn't matter what level it is, when people are on the field or on the court they just want to win, and that can bring the best out in people.
"Soccer is a beautiful game to watch, and people want to see it. It's something different as well, if Americans want to see soccer played at the highest level they need to watch a European team. American soccer is getting better, but it's still a long way off you guys."
Back on the basketball trip, was Jay-Z aware that Chicago Bulls stars Luol Deng and Joakim Noah were big Gooners and have visited Emirates? "No I didn't know that, that's pretty cool. Maybe we could all watch a game together when the NBA season is over, I am sure they would love to come."
And maybe extend an invite last month's magazine feature Idris Elba – Stringer Bell from hit US drama The Wire…
"Sure, why not that sounds pretty cool. With all these people you are inviting over you are going to need a pretty big box if we all come on the same week!"
As well as a globally successful recording artist, Jay-Z is also an entrepreneur with his business portfolio including record companies and clothing lines as well as the stake in the New Jersey Nets. And four years ago, he was even rumored to be interested in purchasing a significant amount of shares in Arsenal Football Club, so could fellow American Stan Kroenke one day be joined on the Arsenal Board's headed paper by Mr. Shawn Corey Carter?
"I am a businessman, and I will always look at an opportunity, and if it feels right great," says Jay-Z, keeping his options open, "I don't know a lot about the business of soccer, but in the future if the right opportunity presented itself then who knows?"
As for the immediate Gunners concerns, it's all about a two-pronged attack on domestic and European fronts, and Jay-Z has his fingers crossed.
"You have always got to hope for the best, and in life you are never out of it until you are out of it," he muses, "It's still a very young team, but youth counts for a lot, and I am confident this can still be a very successful season. If we win the title, then I will make sure I give Arsenal a shout out on stage for sure."
And with that the Official Magazine concludes its interview with perhaps our first non-footballing megastar since Demi Moore back in Highbury's final season. All that's left to do is extend an invitation to a game of his convenience in the future, to which he responds, "thanks for inviting me, that's very cool of you." Any time, Jay-Z, any time.
With thanks to Tom Bennett
Copyright 2017 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source
This article originally appeared in the April issue of the official Arsenal Magazine. To subscribe, call + 44 845 880 0445 or click here.


text:
I have a strong 2 story hive with 1 medium super that swarmed last week. I lost the swarm. I went into it yesterday / Wednesday and found no queen, eggs or larve. Just lots of bees and capped brood and queen cell cups with no eggs in them. I have a helper hive in a single deep that I use to keep an extra queen and brood if I need. I took a frame of eggs and larve out of this hive and put into the 2 story hive to see if they start drawing out queen cells, to see if they are actually queenless.
My question is:
What should I do with the 2 story hive at this point?
Why do you think this hive swarmed? It was in 2 deeps plus 1 medium, no queen excluder and I reversed 1 time to give queen more room and I requeened last september, Italian bees. The medium super had plenty of room???
Thanks, Duane.


text:
2 Beds Apartment in Manhattan LES #28
お部屋の大きさ500 フィート
Floor No.2
- キッチン
- エアコン
- タオル
- インターネット/WiFi
- 鍵つきの部屋
- ファミリー/子供と一緒に泊まれる
- ベビーベッド
- テレビ
Accommodation summary
|Allen Street, 10002 New York, アメリカ合衆国
The apartment consists of a double bedroom and a living room with a second double bed, plus flat-screen TV and dining table. Guests can prepare meals in the fully equipped kitchen, which includes a microwave and coffee machine. The bathroom has a shower cubicle.
The surrounding area is busy, with a great selection of places to eat, drink and shop within a few minutes walk. The famous Bloomingdale's Department Store is a 10-minute walk from the apartment.
Delancey Street Subway Station is a 5-minute walk from the apartment. Times Square, the Empire State Building and the other iconic sights of Midtown Manhattan can be reached in just 20 minutes using public transport.
ハウスルールPlease respect the neighbours and keep noise to a minimum at night.
Please treat the house as you would your own home.
|Weekly rate for up to 2 guests
|¥ 13827949
|¥ 140626 ゲスト・宿泊日の追加
|Check-in before
First time in NYC. Perfect location! We were able to get around really well. Place is good overall for what we needed. Shower adjustment valves could use a bit of work, but there were 4 of us and everything else works and at a very good price in this area. Glad we picked this place.
Very well located at south Manhattan.
Super close to Metro line 6 Green.
A lot of space in side.
The shower was hard to find out the best way to use, but in the and worked well.
A good place to stay with friends.
I stayed with my two children and we had a really nice time. Mike was very helpful and kind. The room was clean, we had everything we needed even though it was quite small, but we were expecting that and it wasn't a problem. We used the room as a base to sight-see and the location was brilliant - so close to the subway and we all really enjoyed being in Chinatown, with great restaurants nearby. The only thing worth mentioning is that there are a lot of steep steps up to the apartment so it wouldn't be good for anyone who has an issue with climbing stairs as there is no lift. For us, it was no problem.
We really enjoyed our stay, even though the room was very small. It was crowded for two people.However, the apartment was clean, the price was good, and Mike was a great host - we can certainly recommend this accommodation to those who just need somewhere to sleep.
Room (clean idem for the bathroom) ok for one week holiday apart from the noise of the air conditionning machine of the neighbour. Practical kitchen for preparing the breakfast. Nice area close to Chinatown.
Henry Street lies in the middle of China Town. You get an authentic insight inton the life of the derscendants of the chinese emigrants.
China Town lies not far from the financial destrict, so you can reach it by walking easily. But it is also very easy to use the public traffic system from here.
You can reach every point of NYC from Henry Street within minutes. Our host was friendly and it was possible to reach him every time by telefon which helped us a lot by arriving from JFK airport to Henry Street. Prize was OK. If you do not more than sleeping and taking a shower next morning you are right here- NYC do not sleep so what about expensive luxury. In summary I give 4 of 5 points. I will come back...Peter and Chris
Mike our host met us on our arrival and provided us with the essentials for getting into the city.
His apartment was in the best location for talking a walk by the Hudson or hopping on the subway Uptown
if you want a bed just somewhere to crash after long days threading through the city - Mike's place is it :-)
This room is perfect for 2 people in a nice clean aprtment on the Lower East side. Mike was a nice host who helped out if you had any questions. Would recommend it to everyone.
Mike who lives There was really nice and friendly. The apartment has a good location!
We enjoyed our stay in this shared appartement: kind host, located in a calm safe neighbourhood (in/nearby chinatown), 1min walk from subway station. All in all a good price/quality ratio!
- すべてのお部屋はチェック済み
- どのホストともお電話で直接お話いただけます


text:
A sharp, upward slap to the back of the head given to someone acting blaringly stupid. Originated from Special Agent Gibbs from NCIS who employs this manuver often.
by plataypusIhateyou October 07, 2005
Made famous by Special Agent Leroy Jethro Gibbs (Mark Harmon) on the t.v. show NCIS, this is an open-handed slap to the back of the head. This is usually done in response to an act of stupidity. Done in a half-serious way to show power.
Once at work, I was playing Tetris on my computer. When the boss saw, he Gibbs slapped the hell outta me!
by Mr._ December 02, 2009
A slap upside the back of the head usually done to someone who did or said something stupid. It was invented by Leroy Jethro Gibbs.
DiNozzo: "An assisted suicide of a suicide bomber whose suicide was before his suicide bombing. It's like how much wood can a woodchuck chuck if a woodchuck could chuck..."
Gibbs gibbs slaps him.
Gibbs gibbs slaps him.
by mcabbyshipper January 17, 2013
A slap upside the back of the head a la Leroy Jethroe Gibbs from NCIS usually done to someone who did or said something stupid.
by legaykidd May 22, 2009


text:
The amount of people who want to do SRPs is a bit disturbing.
by theroleplayaddict December 09, 2015
Since their founding in 1960, SRP Federal Credit Union has been dedicated to their members. The members are the heart of the credit union and the sole purpose for their existence. Today they serve as the financial institution for over 95,000 members; they continue to provide sound savings programs, interest-earning checking accounts, competitive loan options, and a variety of other convenient services tailored to fit their members' needs.
SRP Federal Credit Union's purpose is to help members enjoy a good lifestyle by providing them with a positive incentive to save and build financial stability for today and for the future; they lend them money to help them acquire what is needed to make their dreams come true. They offer their members products and services of a high quality; therefore, their members have developed an appreciation and trust for their credit union. Members can easily access their accounts and control their funds in a variety of styles, including PC TYME secure Internet access, automatic deposit, TYME Line, automatic payment to loans, as well as through their many branch offices. SRP Federal Credit Unions are located in Georgia and South Carolina.
by ZigZagMan January 27, 2011
Abr. for Self Righteous Prick
Best used as a moniker for a sleazy, slimy, cheating, low-life,ex-boyfriend.
Best used as a moniker for a sleazy, slimy, cheating, low-life,ex-boyfriend.
I hope S.R.P. and his witch-nosed girlfriend are miserable together.
by Karen Walker April 10, 2008
by AnimeMan June 19, 2009
by suc c December 18, 2016
Cleveland Steamer Plush
The vengeful act of crapping on a lover's chest while they sleep.Buy the plush
by SFParadoxs May 01, 2017
The vengeful act of crapping on a lover's chest while they sleep.Buy the plush


text:
Rodney Brooks:
Robots will invade our lives
In this prophetic talk from 2003, roboticist Rodney Brooks talks about how robots are going to work their way into our lives — starting with toys and moving into household chores ... and beyond.
Similar topics
- Design
- Humanity
- Intelligence
- Robots
- Technology
This talk was presented at an official TED conference, and was featured by our editors on the home page.
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text:
The only time I stood up to my bullying stepfather was about Star Trek: The Next Generation. The show was on and I walked to the kitchen for ice-cream. Returning, I went for the remote, but my stepfather took it first and changed the channel.
I told him that I was watching Star Trek. He replied something snarky like, "You snooze, you loose, kid."
There were many ways this man held dominance over our lives, and being annoying about the TV was a small one. My usual response would have been to shrug and walk to my room to read a fantasy novel because I really hate fighting. But something snapped. Continue Reading "Star Trek Week: How Voyager Got Me Through It All" »


text:
Local student studying in Australia
Kirstie Harmdierks, the daughter of Kay Johnson of Breezy Point, is studying in Australia during spring semester through the Office for Education Abroad at the College of St. Benedict (CSB) in St. Joseph and St. John's University (SJU) in Collegeville.
Harmdierks is a junior psychology and biology double major at CSB.
The Australia program is located in Fremantle in western Australia, approximately 30 miles from the capital city of Perth. Students enroll at the University of Notre Dame Australia (UNDA), the country's first private, Catholic university.
All students participate in a course on Australian history and society, which includes an excursion in western Australia with a significant aboriginal experience.
In addition, students choose three courses from among their major, minor or general education requirements from the UNDA course catalog.
CSB and SJU students are housed in a student residence on the university campus with some international and Australian students.
The faculty for the program consists of a professor from CSB and SJU and professors from the UNDA. Larry Davis, professor of geology and biology at CSB and SJU, is the director of the program this spring.


text:
Backcountry Skiing Canada reviews the Apex HD+
"Although I am about to offend the majority of male skiers ages 16 - 34 I still have to make my next statement: Having a Go-Pro fixed to your helmet looks ridiculous. It's one of the main reasons I have never invested in a POV (Point of View) camera. The other down fall of most POVs is the whole "Is this on?, hey, Am I on?, Is this working?" routine every time you want to shoot a video. Sound familiar? Bad design all the way around in my humble opinion. So how do you make it better? Well, Liquid Image has made it better by taking the alien third eye off your head and placing the camera discretely in a piece of equipment we already wear, ski goggles. They call it the Apex HD +Camera Goggles."
Read more at BackcountrySkiingCanada.com.


text:
Kieran Gibbs, Wojciech Szczesny, Robin van Persie, Abou Diaby and Bacary Sagna took part in our last Twitter Takeover in late April and this is your chance to re-live the event.
Watch our video footage and read the full transcript below:
Welcome to the latest @Arsenal Twitter Takeover! First up is Kieran Gibbs so get your questions in using the #ArsenalLive hashtag
@nicolaskues_ - @Arsenal who is your favourite left full-back of all time? #arsenallive
Kieran says: "That would be Ashley Cole - in my time anyway. I watched him a lot when I was growing up. I looked up to him" #ArsenalLive
@mickwwarwick - @arsenal #ArsenalLive Kieran, what is it like marking Theo Walcott in training?
Kieran says: "It's a bit of a nightmare! He's one of the best wingers in the league and we know how quick he is" #ArsenalLive
@asyiAFC - @Arsenal #ArsenalLive What's your favourite TV show?
Kieran says: "It's between Two and a Half men and 90210. I have them on series link." #ArsenalLive
@supreetbahl - @Arsenal Who is the slowest driver in the team? #ArsenalLive
Kieran says: "I'll have to say Rosicky. We live quite close and he's given me a lift once - and he's a bit of a granny driver!" #ArsenalLive
@sivasaran007 - @Arsenal what is your biggest fear ? #ArsenalLive
Kieran says: "I am not a big fan of heights." #ArsenalLive
@Badassovic - #ArsenalLive do you take a good free-kick ? Most left backs have a good one
Kieran says: "I take a better corner. I practice free kicks in training but there are a few ahead of me in that department" #ArsenalLive
@Ling2x - Do you have a pregame ritual? #ArsenalLive
Kieran says: "I do the same thing every game, I have done it for years. It's the order that I do things." #ArsenalLive
@abitmel - @Arsenal Who will win the CL final? #ArsenalLive
Kieran says: "Bayern will win it because I would prefer Chelsea not to win it!" #ArsenalLive
Right, that's Kieran finished, next up we have Wojciech Szczesny. You have five minutes to get your questions in using #ArsenalLive hashtag
@joeyc1986 - @Arsenal Do you all play FIFA? If so who's the best? #ArsenalLive
Wojciech says: "I do play FIFA. I am horrible at it. Theo is probably the best." #ArsenalLive
@Hadziie - @Arsenal #ArsenalLive Out of the team, who's shots are the hardest to save?
Wojciech says: "I would say it's Vermaelen - he's got a rocket in his left foot. But he can't hit with his right foot!" #ArsenalLive
@dmdburton - @Arsenal A potato, a pork pie or 4 yoghurts? #ArsenalLive
Wojciech says: "Erm...erm... I dunno. A pork pie, with potato, and yoghurt for dessert." #ArsenalLive
@tomvermeersch - @Arsenal Did you like the beer those fans threw at you in the game against Man City? #ArsenalLive
Wojciech says: "I didn't actually taste it, I covered the end with my thumb as I was scared threre'd be something else in it." #ArsenalLive
@Jakey_Graham - @Arsenal what made you want to become a goalkeeper? #ArsenalLive
Wojciech says: "It's a simple answer: I was shocking as a striker, I couldn't pass or shoot and I was selfish. So I'm a keeper" #ArsenalLive
@janinatoys - @Arsenal If you were to perform in the circus, what would you do? #ArsenalLive
Wojciech says: "I would probably dance with a crocodile, or put my head in its jaws." #ArsenalLive
@SeanCalfe - Szcesny is a lad so whats the greatest prank youv'e pulled on the team-mates? Please says it's to Theo! #ArsenalLive
Wojciech says: "I did something bad in someone's trainers!" #ArsenalLive
Right, that's Wojciech finished, next we have Robin van Persie. You have five minutes to get your questions in using #ArsenalLive hashtag
@Leylaa88 - @Arsenal #ArsenalLive who do you think will win the Euro? You can't say the netherlands ;)
Robin says: "It's hard to name another country but I would go for someone like Spain, Germany, Portugal and an outsider" #ArsenalLive
@mastercedd - #ArsenalLive who's your favourite player of all time?
Robin says: "I have a few. I met Ronaldo from Brazil for dinner a few days ago. Also, Zidane, Maradonna, Cruyff and Messi." #ArsenalLive
@andeshwar - @Arsenal Who is your greatest threat in Table Tennis #ArsenalLive
Robin says: "At Arsenal it has to be Walcott and Szczesny - they have a good standard. It's usually 21-18 against Theo" #ArsenalLive
@AlexWesty16 - @Arsenal who is the worst dresser in the team? #ArsenalLive
Robin says: "It's not Songo, even though he gets a lot of stick. He is a brave man. The worst is Rosicky. he likes tracksuits." #ArsenalLive
@kissmyarsene - @Arsenal have you ever invited the boss to dinner for a bit of captain/manager bonding? #ArsenalLive
Robin says: "No! We do the bonding at the training ground and that works well" #ArsenalLive
@Anubhav_Dev_AFC - @Arsenal Robin, Toughtest/best defender you have faced this season? #ArsenalLive
Robin says: "It has to be the guy from AC Milan, Thiago Silva. He is really good, on the air, on the ball, passes well." #ArsenalLive
Right, that's Robin finished, next up we have Abou Diaby. You have five minutes to get your questions in using #ArsenalLive hashtag
@jimpow77 - @Arsenal who's the best player you've played against ? #ArsenaLive
Abou says: "Zinedine Zidane, definitely. Because he's the best!" #ArsenalLive
@ArsenalFCView - @Arsenal Abou, what is your favourite Breakfast Cereal? #arsenallive
Abou says: "It is Miel Pops. They are nice." #ArsenalLive
@leouzzi - @Arsenal Abou, how much do you think you can bring to the team this season run in? #ArsenalLive
Abou says: "A lot, I hope. I would like to help the team win all three games and get third place" #ArsenalLive
@jackthegooner1 - @Arsenal #ArsenalLive can you dance good, like a robot?
Abou says: "I can dance like Michael Jackson. Not like a robot."#ArsenalLive
@M_Baioumi - @Arsenal what is the best match you have ever played in ? #ArsenalLive
Abou says: "That was at Real Madrid when we won 1-0, and Thierry scored" #ArsenalLive
@the_kun_van - @Arsenal Abou, Do you miss Eboue? #ArsenalLive
Abou says: "A lot. I miss his happiness, even on the pitch." #ArsenalLive
@ace_mayor - @Arsenal who is the best keeper you've played against #ArsenalLive
Abou says: "Buffon. He is amazing" #ArsenalLive
@Rasyiqey - @Arsenal What's your favorite things to do instead of playing football? #ArsenalLive
Abou says: "I like reading, going to the cinema, to stay at home as well and relax." #ArsenalLive
@fatinshafira90 - @Arsenal what are other sports that you like to play? #ArsenalLive
Abou says: "Basketball. I like Miami and LeBron James. I am pretty good at basketball - better than Sagna!" #ArsenalLive
Right, that's Abou finished, last up we have Bacary Sagna. You have five minutes to get your questions in using #ArsenalLive hashtag
@Simon_Breeze - @Arsenal Bacary, what has been your greatest moment in an Arsenal shirt? #ArsenalLive
Bacary says: "Probably the Champions League game against Roma when we won on penalties." #ArsenalLive
@sukhieshergill - #ArsenalLive Bacary how many hours a day do you train, my seven-year-old boy wants to know, he emulates you on the pitch.
Bacary says: "About two hours is a usual training session including time shooting and getting extra practice in" #ArsenalLive
@AhmadAbdelJabe1 - @Arsenal Who is the toughest winger that you have played against? #ArsenalLive
Bacary says: "Messi, when he plays wide. He is the best in the world. Football seems easy when he plays it" #ArsenalLive
@Paul_Delmonte - @Arsenal what is your favourite thing to do with your kids on a day off? I'm a new father and need tips! #ArsenaLive
Bacary says: "Just play with them, and enjoy being with them as much as possible." #ArsenalLive
@BradlikeArsenal - @Arsenal bacary, abou has just said that he is a better basketball player than you, do you agree? #ArsenalLive
Bacary says: "Totally! I have never played basketball in my life, even for fun" #ArsenalLive
@LumosBliss - @Arsenal What's your favorite food? #ArsenalLive
Bacary says: "It is lebanese food, it is quite healthy and tastes nice. I enjoy it." #ArsenalLive
@pejalfdzi - Are you excited to play at Malaysia again later this year? #ArsenalLive
Bacary says: "I am very excited, like all the players. Last year was a great experience for us and we want to go back" #ArsenalLive
Our Twitter Takeover has finished! Thanks to everyone who sent a question - look out for video footage on http://player.arsenal.com/ #ArsenalLiveCopyright 2017 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source


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Discover how much there is to see and do on Molokai. Explore this informative guidebook to learn about the island's top sights and attractions, and the defining qualities that make Molokai so unique. Browse the features below or search the guidebook topics alphabetically.
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From the beaches of West End to the amphitheater-like valleys of the East End, Molokai is an island made for outdoor adventure.
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|Data Dictionary:
|Census 1930
you are here: choose a survey survey data set table details
Survey: Census 1930
|Data Source:
|Digitally transcribed by Inter-university Consortium for Political and Social Research. Edited, verified by Michael Haines. Compiled, edited and verified by Social Explorer.
Data set: Social Explorer Dataset (SE)
|T54. Families By Number of Children Under 10 [6]
Universe: Total Number of Families
Table Details
|Families By Number of Children Under 10
|Universe: Total Number of Families
- Hawaii, Alaska and their counties only have family totals without iterations on number of children.


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She was ugly, but that's what made her a winner. It's also how Yoda, the champion of the 2011 World's Ugliest Dog contest, will be remember by after passing away last Saturday. The 1.8 lb Chinese Crested and Chihuahua mix-breed won first place at the contest at the Sonoma-Marin Fair in California. The scrappy 15-year-old pooch beat out 29 other competitors with her scraps of hair, hanging tongue and legs that mimicked a balding man's hairline.
According to her owner, Terry Schumacher, Yoda passed away in her sleep.
"Say a prayer today 4 my YODA...rest in peace 3-10-12," said Schumacher in an email regarding Yoda's passing. "She passed away last night in her sleep. I will miss her funny little ways! But comforted knowing she will be joining my Mom and Dad, who loved her so much! Her memories will live on forever!!!" reports the Hanford Sentinel.
While it was Schumacher who took Yoda to win the Californian dog show and the $1000 grand prize, it was actually his daughter who found the dog behind an apartment building. Schumacher at the time mistook the pooch for a rat.
Despite being deceased, Yoda will hold onto her title until the 2012 World's Ugliest Dog contest according to contest producer Vicki DeArmon.
If you thought Yoda was a little rough on the eyes, get a good look at these 10 unsightly creatures that could offer any W.U.D. champion some extra competition:
Dog lovers and cat lovers can set aside their differences and agree upon one thing: Sphynx cats are pretty unsightly. Despite their Egyptian-inspired name, this breed is actually Canadian. The first Sphynx cat was born in Toronto after a domestic cat gave birth to a hairless kitten due to a natural mutation. .
No, that's not a miniature albino walrus you're looking at, though the resemblance is uncanny. According to National Geographic, the naked mole rat is one of 30 species of mole rats in the world. A study from the University of Rodchester has also revealed that these hairless critters have a high resistance to cancers.
This is the Aye-Aye. Aye-Aye is also what you'll probably scream out during a nightmare if this animal and its glaring yellow eyes enter your dreams. Native only to Madagascar, the Aye-Aye are fans of finger foods. That's because of their long, slender fingers that they use to pull out grubs found in trees when hunting nocturnally. (Photo courtesy of Flickr/ Frank.Vassen)
"Why Tarsier, what big eyes you have." "All the better to see you with", said the small primate native to Southeast Asia. Distinguished by their large eyes, these animals have eyeballs as large as 16 mm in diameter -- the same size as their brains.
The second mole to join the list, the star-nosed mole looks like something from a John Carpenter horror film but is actually an animal that prefers to swim and dig tunnels year round. It's characterized by the eleven pairs of pink fleshy appendages that surround their snout. These feelers help the mole move around through touch. (Photo courtesy of Flickr/gordonramsaysubmissions)
While it resembles the illegitimate love child of a lizard and a fish, the Axolotl is actually a type of salamander native to Mexico. The amphibian is so well known for its frilly gills that it is sometimes taken in as a pet. (Photo courtesy of Flickr/Jan Tik)
One look at this critter and you can understand why Batman chose the bat as a symbol to strike fear into the heart of his enemies. The bat gets its name from the shape of its squashed nose and horseshoe-shaped nostrils. It can be found hanging out in areas such as southern Europe, Africa, parts of Asia and eastern Australia. (Photo courtesy of Flickr/Schmeegan)
At first glance, the hagfish may look more like an eel than a fish, but what makes the hagfish ugly isn't its appearance -- it's the way it defends itself. When attacked, the hagfish releases a goo that turns into mucus as soon as it comes into contact with water. It's the equivalent of playing tag with a kid who always sneezes on you every time you catch them. Gross. (Photo courtesy of Flickr/dirtsailor2003)
The blob fish has good reason to look miserable: it is on the verge of extinction due to overfishing, after all. Native to the coast of Australia, it's endangered because of fishers who capture them using crawnets despite the fact that they're inedible. Blob fish get around by floating near the bottom of the ocean floor and will eat whatever they can catch. (Photo courtesy of Flickr/Claf Hong)
If there was ever an animal that proves beauty is only skin deep, it would have to be the monkfish. While gruesome by appearance, the monkfish is actually a delicacy in Canada and the US. The tail meat has a similar texture to lobster, thus earning the nickname "the poor man's lobster".


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Farmers who plan ahead for tax management maximize their benefits.
by Ali Enerson, Hoard's Dairyman Special Publications Editor
Tax time can bring mixed feelings for farmers.
Some are worried about pulling that shoebox full of receipts out that they shoved under the desk. Others know exactly what their tax preparer will say since they strategically bought or sold in the fourth calendar quarter to take full advantage of credits and deductions. Most farmers, however, fall somewhere in between.
There are a few tips you can begin implementing now to handle tax management with ease this new year.
- Ensure all expenses are taken by keeping good records. If you don't have a smooth-running expense tracking system in place, now is the time to try something better.
- Evaluate what portion of business-personal expenses you can deduct based on your situation. Electricity, phone costs and auto deductions are easy to overlook. Mileage for charitable and even medical purposes may be itemized.
- Know what credits are available to you. Taking advantage of tax credits will help you maximize your dollars.
- A Health Savings Account (HSA) may be a good alternative to standard health insurance. HSAs allow income tax-free contributions to the account and may be used tax free for qualified expenses.
- Look into a retirement plan, and learn the benefits of maximizing your contributions each year. There are many types: SEP IRAs, Roth IRAs, IRAs and even SIMPLE plans for small employers to encourage employee retirement savings.
- Plan for your retirement. Don't let retirement sneak up on you. Devise a plan for more income from rent, dividends and interest rather than earned income.
Set up a system to track expenses or implement a new program today. Keep your systems simple to make your life easier. Come tax time 2015, you'll be grateful you formed a new habit this year.
The IRS publishes a Farmer's Tax Guide, publication 225, that provides some great tax information for farmers.
The author is the special publications editor, responsible for books, plans, distribution of the e-newsletter and various internal communication pieces. She grew up on a 60-cow dairy in northwest Wisconsin, and is a graduate of University of WisconsinMadison with a degree in life sciences communications.
Click to subscribe to the HD Notebook RSS.


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- Free Small Business Online Banking and Small Business Online Bill Pay2
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|Check Card and ATM
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How do I qualify?
- Simply combine your personal and business account and loan balances
- There are 3 ways to qualify:
- Maintain Total Deposit Account Balances of: $25,000
(includes business and personal checking, savings, money market, CDs and consumer IRA balances)
- Total Loan Balances of: $25,000
(includes outstanding balances in business loans, personal installment loans, home equity loans and credit lines)
- Combined Deposit and Loan Balances of: $40,000
(includes all balances in your personal deposits, business deposits, plus your outstanding balances in business and personal loans)
- Maintain Total Deposit Account Balances of: $25,000
- $25,000 total deposit balances or $25,000 total loan balances or $40,000 total combined deposit and loan balances. $25 service charge each month minimum combined balance requirement is not met.
- One free Online Bill Pay account per business.
- First 300 transactions per statement cycle are free. These transactions include paper and electronic (ACH) debits, credits and deposited items, and Online Bill Pay-generated checks and ACH debits. Additional transactions are $0.50 each. The Business Visa Check Card and Bill Pay products are free, but the use of the products may count towards the accounts transaction limit.
- Three free Non-Commerce ATM transactions per month on Business Visa® Check Card. Non-Commerce ATM transactions must be made from primary checking account and other banks' ATM fees may apply.
- Loan rate discount offered for automatic payment from your Commerce checking account. Please ask about CommerceOptions for more details.
- On balances greater than $10,000; premium rate on balances above $100,000
- To send an email that contains confidential information, please visit the Secure Message Center where there are additional instructions about whether to use Secure Email or Online Banking messaging.


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Driver hits people leaving church
BOISE, Idaho (AP) - Police are investigating a motorist who crashed into a crowd of pedestrians who had just left a funeral at a Boise church.
Authorities say nine people, including a 5-year-old child, have been taken to the hospital for injuries.
The collision occurred Monday afternoon on the city's west side.
Boise Police Spokeswoman Lynn Hightower said the motorist was parked next to the sidewalk before he unintentionally accelerated into the crowd gathered outside a Mormon church.
Police have not identified the driver, who was not hurt. But a female passenger in the vehicle was among those taken to the hospital for medical care.


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LOL. Ok. Bear with me for a second here on this one.
Seeing as I'm always winging the topics for these discussions, yesterday's FMR 1 year Anniversary post gave me an idea for a "Tossin' It Out There" that's a little "High Concept".
Ok, let's say we were going to have a party.
What Movie Characters would you bring, and why?
You want to invite Channing Tatum and John Travolta to get some dancing going? Fine. Rollergirl and some of her Boogie Nights friends? Awesome! Darth Vader and Chewbacca to work security? Good idea! Alfred from Batman to clean up the joint after we're done? GOOD thinking…
Maybe your idea of a party is a more formal affair, and you're bringing Rick from Casablanca. Or its a complete Bacchanal and you're inviting the Project X crew.
Whoever it is, for whatever reason, let's have some fun today and see how this one turns out. We're throwing a party and you can invite any movie character or characters you want.
Who are YOU gonna bring?


text: What you can do to help Wisconsin workers Dedham Education Association President Timothy Dwyer and his wife, Debbie, traveled to Madison to support Wisconsin workers. Recently, MTA members joined with activists from other unions and communities across the Commonwealth in an incredible show of support for our counterparts in Wisconsin.Clearly, the Wisconsin governor's plan to strip public employees of their collective bargaining rights has hit a nerve and sparked a national debate about the role of unions. Thank you to everyone who turned out at our Stand Up for Wisconsin Workers rallies in Springfield and Boston. To learn about future developments and events, sign up here.Please sign NEA's online petition, We Pledge To Stand With America's Educators, School Support Staff And Workers: http://www.educationvotes.nea.org/nationalpetition/Donate to the 51 Fund: By donating to the 51 Fund, support will go to where the need is greatest: to assist people fighting back on the frontlines. The 51 Fund will help feed volunteers, organize rallies, and get the message out to people everywhere that the right to collective bargaining ensures a strong middle-class. And, a strong middle-class is the back-bone of our economic vitality.http://51fund.neafoundation.org/For more information:Wisconsin public servants already face a compensation penalty and Public sector workers earn less (Economic Policy Institute) State gets a good deal on teachers' pensions (MTA) Sign Up for Email Updates Visit our social media sites for conversations, photos, videos and the latest news: MTA on Facebook MTA onTwitter MTA on Flickr MTA on YouTube Show Your Support on Facebook and Twitter:Right click on the image at left and save it to your computer.Facebook:Sign into Facebook and go to your personal profile. Hover over the upper-right-hand corner of your current profile picture. Click "Change picture." Click "Upload picture." Browse your computer and select the image you saved. Twitter: Sign into your Twitter account. Click "Settings" at the top of the page. Click "Profile" then "Change Image." Browse your computer and select the image you saved. Click "Save" at the bottom of the page and your profile picture will be updated.Use the #ma4wi hashtag in your tweets! Subscribe to MTA News Headlines by Email


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Very nice. All things come to those who wait. How fortunate for you.
Very nice. All things come to those who wait. How fortunate for you.
Mark Berninghausen
That's a large chunk of change ! 20 K ... That is my entire take home pay for the year. Wow.
Another reason i would like to have a second income other than my wife to be's . With the price of gas rising and everything else effected by it going up , it's hard to live on that . even being very careful with our money , it's seems there isn't much left over LOL I'm sure there is a lot of people doing the same or worse , I am just trying to make the most out of my life .
Very well said and put Joel.
Ben, what's your goal? What's your dream? What are you willing to give up to reach your goal or dream. I imagine that most people enjoy their standard of living and aren't willing to sacrifice it to become a full time beekeeper. If you are a good businessman maybe you don't have to. But, unless you can get your spouse fully involved and willing to travel w/ you, you will spend a lot of time apart. Michael Palmer and others like him being the exception.
If you are serious about expansion into fulltime beekeeping and don't want to travel w/ your bees and spend a lot of time away from home and family follow Michael Palmers way. It works for him and works well.
Mark Berninghausen


text: Well, thanks a bunch! You've all given me something to look forward to...haha Seriously, I have FF on my other computer and I did something there that wiped almost all of them away. Remember the overflowing toilet? Killed that in a NY minute. But this Google chrome---I can't figure it out. I'm going to FF tomorrow.


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Local Boy Scouts group reels in Big Rock grant
Leaders of the Big Rock Blue Marlin Fishing Tournament have awarded a $75,000 grant to a local Boy Scouts group.
The grant was given to East Carolina Council, BSA, based in Kinston. The $75,000 will be used to build a land-based pirate ship at Camp Sam Hatcher in Newport, said Crystal Hesmer, tournament director of Big Rock.
The grant from Big Rock will be matched by East Carolina Council, BSA with an additional $75,000.
"An important reason for making the grant to East Carolina Council, BSA was their willingness to share in the cost of building the pirate ship," said Tom Bennett, Big Rock's charity chairman. "This is our first experience with an organization to ask for a matching gift instead of asking the Big Rock Marlin Fishing Tournament to fund the entire cost of the project."
The pirate ship will be used primarily as a Cub Scout camping facility, according to Ben Moore, strategic planning chair of East Carolina Council, BSA. The ship will have three cabins: one for adult males, one for Cub Scout youth members and one for adult females. The deck of the ship will serve as a play area and stage for contest and other activities.


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by ev_pl July 01, 2006
One who is obsesed with the once popular TV show "Star Treck". Treckys ushaly live an unfufilling life that results from living in there moms basment until they are 35. Often never losing there virginity, Treckys resort to advanced hand technics such as the Vulcan Salute.
by Nayre November 03, 2005


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Lovely Apartment in Paris (330)
Vendégek száma4
Hálószobák száma1
Méret40 m²
Floor No.
- Konyha
- Mosógép / szárítógép
- Internet/WiFi
Accommodation summary
|Rue des Francs Bourgeois, 75004 Paris, Franciaország
|Ingatlan típusa
|Ingatlan azonosító
|Acceptance rate
|< 50%
|Response time
|A few hours
|Calendar updated
|More than half a year ago
Between Gardens and historic monuments, you will be there in the smartest and styliest Paris. Five minutes walking distancefrom Rue de Rivoli, the subway Saint Paul and thus the line 1 of the subway takes you to the main monuments of the capital (Louvre, Concorde, Champs Elysées, Arc de Triomphe etc.)
The apartment overlooks a courtyard and will charm you by its peace and its exposure.
Furnished in a cosy and modern style you will pleasantly be surprised by the volume of the apartment and the light brought by two big windows. Very functional, its offers an Italian-style shower, a fully fitted kitchen, a large flat screen television. On the bedroom a king size bed will allow you to take advantage of an undeniable comfort.
HázirendDeposit of 500 €
Arrivals and departures between 21:00 and 08:00 are charged € 30 (There is also a surcharge for arrivals and departures on Christmas, New Years and Easter)
No smoking
Pets not allowed
|Weekly rate for up to 4 guests
|1031 €
|Monthly rate for up to 4 guests
|3684 €
|Érkezés legkorábbi időpontja
|Check-in before
|Távozás legkésőbbi időpontja
|Lemondási feltétel
A házigazda egyéb ingatlanjainak értékelései
The appartment has an unusual but interesting and smart floor plan. Lots of rustic and old feel mixed with modern stuff.
We were missing a pair of scissors and a coffee mug or two, but after a mail to John we got the stuff the same day.
A faint odor from the very bottom of the stairs connecting the loft with the rest of the apartment but it wasn't too bad.
Overall we were very happy with our stay.
The Hollmark family from Stockholm, Sweden.
Nice, clean and perfectly located. Highly recommended!
I went to Paris to spent four days with my sister and I found a very dirty flat. Anyway the neighborhood was very nice. We had to change the sheets because they had stains. Under the table there were some dirty socks. Wifi was available only for first 24 hours. I had to contact with the owner five times and the only answer was "how can I solve the problem?, in most places of Paris there was free wifi."
I wouldn't recommend this flat because it's was a unpleasant experience with it.
We had a wonderful time in Paris and mostly because of our quite small but very comfortable and convenient apartment. It's situated in a strategic position: Although it's really close to any kind of shop and many good restaurants and bars, it's in the internal part of the building so it is very silent. Absolutely suggested.
The apartment is smaller than the pictures, and is no so beauty as the pictures.
Actually this is not a recommendable place.
When we arrived we think "We should have gone to an hotel".
We never met John as from what I understand this is a company of various apartments in Paris, so we were greeted by Guillermo (I presume an employee) a very pleasant guy who was happy to give us some tips on the Area but as he had to shoot off to another apartment could not stay to long and chat.
The flat is small, smaller than the actual pictures (30 m in totall / 2 rooms ) but nice and clean. Kitchen is also smaller in real life! Bathroom is a few years old but clean. To be honest we where a bit disappointed with the size since for this price I think we could have got a larger / nicer flat but due to late booking this was one of the few available for our dates and Area,
Advantages: The area, Le Marais is one of the better spots to stay in Paris , (close to everything) and the district is quite trendy with many places to dine and wine and shops / Galeries and the Sunday market is quite an experience.
Disadvantages, the price and size of apartment, being an attic with fairly high windows does not help too much, although the flat is quite bright.
In all not sure if we got our value for money here, I have seen better flats with similar or lower prices, however the service was good and no real complains with the company or Wimdu
Would I go back to the same flat, I dont think so as next time I would book in advance just to find a better deal for my cash.
Excellent location!!! The apartment is in a great supurb surrounded by some of the cities best cafes. Only downsides were it was on rthe 6th floor with no elevater and the hot water does not last long. Other then that, the apartment is well equiped and i would definately rwcommend a stay here
Excellent appartment and excellent location. Well equipped and suiteful for a sall family.
The apartment is charming, quiet and well situated. It has everything that you need. I would suggest a couple of improvements : 1. The fridge needs to be changed or fixed as it was leaking water. 2. The extra pillows have to be changed as they were too dirty.
lovely place, and great to communication.
- Minőségbiztosított szállás
- Minden házigazda hitelesítésre került telefonon keresztül
- Biztonságos fizetés SSL titkosításon keresztül


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Discussion in 'POLLing place' started by ChevyFan, May 26, 2007.
I drive much less because of the high gas prices. How have gas prices affected you?
yes, I skipped needless trips. Fuel prices keep on getting ( €1,50 per liter) worse over here. I'am thinking of converting the car to LPG.
Now if I can get the wife to stop impulse shopping at that stupid Walmart...Gawd I hate that store. Honey can go here honey can I go there...Ah shut up and leave me alone. :lol:
Sounds like it's the perfect solution. If you want to be left alone, let her shop at Walmart. At least she's not shopping nieman marcus.
Shaving kit...what a bargain at only $100.00 before shipping
All three of the YES options apply to me.
I only use my vehicle when I need to. I walk the 2 blocks to Wally World instead of drive there unless I need a lot of things.
I think we are going to sell the Suburban and buy a HHR. It makes me sick because I just got the Suburban the way I wanted it
well back to nieman marcus, i dont need to shave my face that bad. I'll take the buck knife to it and use sour cream for shaving cream before i spend 100 dollars on it. I NEEED THAT MONEY FOR GAS!
Seeing we have so many vehicles on the road and off I just consolidate trips to the vehicle that will do the job.
The Fiero has always been a grocery getter and errand car.
The Burb is more of a tow/feed/ family car.
The full size Ford vans are just used to get hay, 30 square bales at a time, rain or shine.
The plow truck is just for plowing and fencing so that really hasn't seen much use at all lately,
Now the golf cart has gotten a lot of use lately, we use that to haul meals around for the animals on the farm and getting to and from garden spots.
But I have considered using it to get to Wally World, we are less than a ¼ mile from the back entrance. All I would have to do is register it as an ATV and it would be legal to do that.
Thats what I'm talkin' bout! You can have my little trailer for the back of it. I'm done fooling around with it.
Separate names with a comma.


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Owen Yalandja is a Kuninjku artist from Maningrida in Central Arnhem Land and a senior member of the Dangkorlo clan. Born in 1962, he is a noted sculptor whose exceptional works have gained much attention and prominence in recent times, particularly his exquisitely carved yawkyawk spirit figures.
The yawkyawk are believed by Kuninjku to be young girl spirits or ancestors who live in the water and whose shadows can sometimes be seen as they run away from humans who might come near. Yawkyawk are a recurring theme in Kuninjku bark paintings.
Yalandja's father, the late Crusoe Kuningbal, was a famed Kuninjku singer, dancer and ceremonial leader, as well as an accomplished painter of barks and a carver of the mimih spirits. Mimih spirits are believed by Kuninjku to be long, thin, mischievous beings who inhabit the rocks of the escarpment country. Kuningbal is said to have invented the songs and dances of a public Kuninjku ceremony called Mamurrng for which he danced the mimih and in which he incorporated life-sized carvings of them.
After their father's death in 1984, both Yalandja and his brother Crusoe Kurddal produced large mimih carvings similar to the ones made by their father for the Mamurrng ceremony. In the 1990s Yalandja began to experiment with the dot patterning taught by his father, and created the 'v' shaped fish-scale patterning in his sculptural representations:
I make it [yawkyawk] according to my individual ideas … My father used to decorate them with dots. A long time ago, he showed me how to do this. But this style is my own, no one else does them like this.[1]
I make it [yawkyawk] according to my individual ideas … My father used to decorate them with dots. A long time ago, he showed me how to do this. But this style is my own, no one else does them like this.[1]
Yalandja's brother Kurrdal has continued to carve mimih spirits while Yalandja now concentrates on the yawkyawk.
Since the yawkyawk are imagined as spirit girls who were transformed into mermaid-like figures with fish tails, in depicting scales on his sculptures – first as arc-like shapes and later refined to the 'v' shape – Yalandja has effected a unique innovation. He has also experimented with using black as a ground colour, rather than the red other family members use. Yalandja's yawkyawk sculptures also tend to have a tapering body ending with a forked fish tail. He selects pieces of wood that best suggest movements in the fish-like forms, sometimes making use of natural forks to portray the tail. In other works he has selected curvilinear tree trunks to depict the slender and sensuous yawkyawk forms. These yawkyawk sculptures, with their exquisitely rendered scales, have a special beauty and sensuality not always associated with three-dimensional Aboriginal forms of art.
Yalandjais one of Australia's most accomplished sculptors. He is also a recorded didjeridu player and a well-known singer for yawkyawkstyle diplomacy ceremonies. The five magnificent yawkyawk sculptures he has contributed to Culture Warriors attest to his respect for tradition and his capacity for artistic innovation, for which we can all be grateful.
Gary Lee
[1] Maningrida Arts and Culture website, viewed 2 April 2007, maningrida.com.


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You are here:
Home>Exhibitions>Selected Past Exhibitions>2008>Impressionist Interiors
Supported by KPMG
This exhibition brought together over 45 wonderful paintings and drawings by Manet, Monet, Renoir, Morisot, Degas, Cassatt, Gauguin and Pissarro, on loan from public and private collections throughout Europe and the United States of America. It was the first serious survey of this particular dimension of Impressionism, and showed some of the many and varied ways in which Impressionists and artists within their circle engaged with interior spaces both public and private, domestic and social.
Janet McLean, curator of the exhibition and editor of the accompanying catalogue said: "Artists associated with Impressionism did not just aspire to be painters of light and air but aimed to be modern artists and thereby painters of modern life."
Impressionist Interiors featured 12 paintings and pastels by Edgar Degas, among them, Portraits in a Cotton Office (Museum of Fine Arts, Pau), The Convalescent (J. Paul Getty Museum, Los Angeles); After the Bath (Philadelphia Museum of Art) and Café Concert at Les Ambassadeurs (Museum of Fine Arts, Lyon). There were also some fine examples by Paul Gauguin, The Painter's Home, rue Carcel (National Museum, Oslo), Nude Study/ Woman Sewing (Ny Carlsberg Glyptotek, Copenhagen), and The Little Dreamer (Odrupgaard, Copenhagen).
Édouard Manet, like Edgar Degas was essentially a painter of the modern interior. He said to Berthe Morisot: "you can do plein-air painting indoors, by painting white in the morning, lilac during the day and orange-toned in the evening". Manet's oil studies, A Bar at the Folies-Beregère and The Ball at the Opéra (Private Collection), were included in this exhibition, as well as Interior at Arcachon (Sterling and Francine Clark Art Institute, Massachusetts).
The exhibition also included a number of works by women artists associated with Impressionism: Berthe Morisot, The Artist's Sister at a Window, (National Gallery of Art, Washington); Eugène Manet On the Isle of Wight (Musée Marmottan Monet, Paris) and Mary Cassatt, Lydia at a Tapestry Frame (Collection of the Flint Institute of Arts, Flint, Michigan). Also featured were Camille Pissarro, Minette (Wadsworth Atheneum Museum of Art); Claude Monet, Interior, after Dinner (National Gallery of Art, Washington) as well works by Pierre Bonnard and Edouard Vuillard. Featured too were some lesser-known artists who engaged with interior views: Zacharie Astruc, Henri Gervex, Frédéric Bazille and Federico Zandomeneghi.
Exhibition Catalogue:Impressionist Interiors© 2008 National Gallery of Ireland and the AuthorsEditor Janet McLeanProduced with the assistance of the Department of Arts, Sport and TourismISBN 978-1-904288-30-5
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Bend delays water project work amid court fight
Ruling on foes' injunction bid sought by Jan. 20
BEND, Ore. - The city of Bend has delayed work on its controversial water pipeline project -- not due to this week's frigid, snowy weather, but under an agreement to wait for a federal judge's ruling on opponents' request for an injunction to block the project.
Under a stipulated order signed last Tuesday by U.S. District Judge Ann Aiken in Eugene, the city agreed not to begin any work at the project site, including staging and site preparation, under a U.S. Forest Service special use permit until Jan. 20 or a ruling on the injunction and temporary restraining order request, whichever comes first
The Forest Service, meanwhile, agreed not to restrict public access to the project site while the court proceedings go on.
Foregoing an immediate hearing over the holidays, the defendants -- the city and Forest Service, now have until Dec. 16 to file their response to Central Oregon LandWatch and WaterWatch of Oregon, which is seeking to block the multimillion-dollar project.
Then, the plaintiffs will have until reply brief on Jan. 3, the order stated. Aiken then will "hear the matter as soon as practicable thereafter," it said, adding that the parties are seeking a ruling before Jan. 20.
The defendants in the case are actually the Forest Service, Deschutes National Forest Supervisor John Allen and Regional Forester Kent Connaughton, with the city weighing in as intervenor.
The order notes that the plaintiffs filed the lawsuit, asserting the federal agencies' environmental analysis of the Bend Surface Water Improvement Project is inconsistent with the National Environmental Policy Act and also claiming that the project violates the National Forest Management Act, Clean Water Act and Federal Lands Policy and Management Act.
A similar suit filed last year delayed the project and prompted a new Forest Service review of a city proposal to cap the amount of water removed from Bridge Creek, a tributary of Tumalo Creek – a move the critics said fell far short of protecting and improving Tumalo Creek's fish and wildlife habitat.
The opponents have claimed the city could end its use of two water sources and use only groundwater brought to the surface by pumps, at a far smaller cost and less environmentally damage. The city has rejected those claims and the city council has moved, in divided fashion, to protect what many call a valuable dual sources of water. City councilors have called a special meeting for next Friday to discuss the water project.