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forum: Campaigns and Community
Pages: 1 2 | Home » Campaigns and Community » School Dinners
#1 Wed 23 May 12 11:09am
Mad parent
- Member
- Member since Wed 23 May 12
School Dinners
Hi, I have been a mum in the school system for 25 years, and over the last few months I am losing the will to live as far as school dinner, the so called cooks and the the rules everyone in school kitchens should live by.
In the last few month my children have repeatedly been given food with the cooks hair in it.....yuk!!!! When I have spoken to the school, asked why the cooks don't wear hair nets am just ignored. My children have time and time again come home with upset tummy's, I know the answer is send them in packed lunch but I can't afford it, so they have me over a barrel. The other day my daughter saw a hair in the potatoes and the cook took her plate back and without gloves on removed the hair. Then gave it back to her. I really dont think this is good enough.
Also healthy food, well thats a laugh. fish finger pie...... This is fish fingers covered in baked beans then cheesey mash baked... my children say its really nasty.
I might not be so angry but I live in the middle of the country surrounded by field of veg. It so cheap to buy veg here. It really does'nt make any sense to me.
Let kids eat healthy food instead of rubbish.
#2 Wed 23 May 12 12:01pm
- Forum champ Occupation Retired pipeline precommissioning financial engineer
- From Surin, N.E. Thailand
- Member since Mon 29 Dec 08
Re: School Dinners
You don't say which country you are from.
#3 Wed 23 May 12 1:50pm
Mad parent
- Member
- Member since Wed 23 May 12
Re: School Dinners
Hi Am from UK.
#4 Wed 23 May 12 2:05pm
- Forum champ
- Member since Fri 19 Nov 10
Re: School Dinners
If they'll decde to stay there I'll have a granddaughter going to school one day there please fight for her aswell you have all my support in being arrabbiata (madamada was my previous name here, I thought it as being mad but amada/loved)
what you say about having all sorts of vegs and giving children makes me so very angry
#5 Wed 23 May 12 7:47pm
- Member Occupation Office Wallah
- From Yorkshire / E Sussex
- Member since Thu 15 Mar 12
Re: School Dinners
Cheap veg? Theres your answer!
#6 Wed 23 May 12 8:15pm
- Forum super champ Occupation avoiding housework
- From The land of song.
- Member since Tue 04 Oct 05
Re: School Dinners
welcome to the forum Mad parent
Are your children in the state school system or the private school system.
I am afrais the school cooks do very very much from school to school as do the schol dinners vary.
The only advice that I can give you is to in the first instance write to the school head teacher and if ask if you can call to see her/ him to discuss the matter .
This is always a good start .
I am unsure if this is what you have already done , as you said that you spoke 'to the school' but not who you spoke to .
In most schools the catering is run by the council and not by the school itself.
Dispite this it is always god to discuss the matter with the school head teacher.
Can your children take in a packed sandwich lunch or do they need to have a cooked school lunch ?
#7 Wed 23 May 12 9:05pm
- Forum champ Occupation Project Manager
- From Limassol, Cyprus
- Member since Tue 19 Dec 06
Re: School Dinners
Sounds like the issues you raise would be more of a problem for the Environmental Health Department. Perhaps talking to your local one would yield some results. The issue I'm getting from your post is down to piss poor personal hygiene on the part of the caterers.
#8 Wed 23 May 12 9:46pm
- Forum super champ Occupation Just being me
- Member since Fri 28 Mar 08
Re: School Dinners
I believe there are two issues - violations of health and safety regulations by food workers and poor quality food. Here in the U.S., they must wear a hair net or some form of hair control. Once the food is served, if it's returned to the kitchen, they are obligated to serve a new plate of food. It's incorrect for the food worker to serve food she/he knew was unsanitary because it contained hair. That food should have been binned and the child given a fresh plate of clean food.
It's no wonder kids feel so knocked around by authority and fed up with the way they're treated in school. It's very dehumanizing for a child to be served unsanitary food.
I'd be tempted to bypass the school on the food safety issues and instead contact food safety authorities. You should take up the other issues of your children not being given basic respect by employees of the school and the quality of food served with the administration. I would say that you might suggest they offer a salad bar, but as it is, your children should not be eating anything uncooked that's been handled by food workers who violate food safety regulations constantly.
Last edited by MsPablo (Wed 23 May 12 10:50pm)
#9 Thu 24 May 12 7:28am
- Forum super champ Occupation avoiding housework
- From The land of song.
- Member since Tue 04 Oct 05
Re: School Dinners
I would not relate the children having 'upset tummies' with the school dinners , sadly people DO send their children to school with 'upset tummies ' or sickness bugs , it could possibly have been caught from another child , it might also be an issue with something as sime as the soap in the toilets not being refilled .
If the children getting 'upset tummys' was to do with the school
Dinners there would be a large number of children unwell at one time and the matter would likely have been reported to the authorities for investigation.
With the hair in the food , in the school kitchens in the authority where I love the cooks wear hats , check out the policy in the area that you live .
Now I am in no way doubting the child , but children do sometimes say things that they think adults want to hear or they say things for effect to achieve a goal .. This could be protesting about the dinners to enable a sandwich lunch to be made.
Sandwich lunches need not be expensive , some children in the school that I help in take things like a pasta salad , or couscous with roasted vegetables or some often bring leftovers from the evenings supper . flasks of homemade soup or a bit of Dahl and a chappati ..whilst others bring lunches that are of no nutritional value .
You do not have to follow the trends and send a child with crisps/ potato chips , chocolate biscuits and the like , things like homemade flapjacks are cheap and easy to make filling and enjoyable , children can also help to make them.
I still think you would be better aproaching the head teacher in the first instance , she/he should be able to assistain if there have been other children have had similar issues with the school dinners .
If you don't feel your queries have been awnsered then you could go to either the school goveners of the local education authority as they will know who is contracted to do the catering.
Personally thinking , I do not think that a hair in food is something that an environmental health department would initially get involved in unless it had caused a problem to the health of the individual .
A hair found in food might be unpleasant and off putting but a single human hair is unlikely to be much risk to human health.
However , I am not saying there is not a problem with this school kitchen , it does sound like that they need a bit of help .
Regards the quality of what is being fed to the children for their school dinners , that is very much down to each indervidual school authority as they set the menus and dictate where food stuffs are provided from , the school itself has little to do with the process ( as far as I am aware ) the school will send in numbers of children eating school dinners and ensure that they have the correct supplies in their pantry to cook the weeks menu . The council set the menu and organise the suppliers and supply of the food stuffs , the school simply cook what they are told they have yo cook on each day .
#10 Thu 24 May 12 1:34pm
- Forum super champ Occupation Just being me
- Member since Fri 28 Mar 08
Re: School Dinners
It's not a big health issue to find one hair in food, but apparently her kids find hair in the food often and the staff isn't using any hair control. If that's a violation of food safety regulations, and it should be, then she has a right to bring it up to the proper authorities.
I'm not suggesting the hair in the food made the kids sick. I'm saying, it's disgusting and should be against health codes. Just because they are children, does not mean that they should have to eat something with hair in it because it could be coated with hair spray or other hair products or dandruff, sweat, dust, pollution or worse! Hair picks up a lot of crud from the air and scalp secretions. It shows a lack of basic hygiene and care in making the food which could indicate they are not careful in other ways as well.
Last edited by MsPablo (Thu 24 May 12 1:42pm)
Pages: 1 2 | Home » Campaigns and Community » School Dinners


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In December, we asked TFK readers to choose the most important newsmaker of 2013. More than 11,000 votes were cast, and the results are in! Who is TFK's Person of the Year? For the fifth year in a row, TFK readers chose the 1.4 million men and women serving in the U.S. Armed Forces. They proudly represent the U.S. while working overseas and they help our nation in times of crisis at home. The U.S. Armed Forces received more than 3,000 votes in TFK's poll.
To Serve and Protect
Every day, the men and women of the U.S. Armed Forces put their lives on the line to protect our freedoms and keep our country safe. There are currently 47,000 U.S. troops serving in Afghanistan alone. The troops were supposed to return home by 2014. Unfortunately, there is more work to be done. The plan now is for 12,000 soldiers to stay behind and train Afghanistan's security force, which is not yet capable of defending the country on its own. U.S. troops are now being deployed throughout Africa as well. Their role there will be to teach local forces how to tackle terrorist threats.
Over the past decade, women have fought alongside men overseas, though women were not technically allowed to serve in combat roles. But on January 24, 2013, women earned an expanded role. The Pentagon signed an order opening all ground-combat military positions to women.
Our armed forces are important in times of peace, too. Soon after a powerful tropical storm called a typhoon left thousands dead in the Philippines, U.S. troops arrived with rescue teams. The U.S. military helped distribute food, water, and other supplies to the island nation, where many were left homeless.
Other Notable Nominees
Singer, actress, and songwriter Ariana Grande received the second highest number of votes for TFK Person of the Year. Many people hadn't heard of the 20-year-old singer last year, but Grande gained attention in 2013. In September, her album received positive reviews from music critics and her song titled "The Way" became a top 10 hit on the Billboard Hot 100 list. In November, she was named New Artist of the Year at the American Music Awards.
For the second year in a row, 16-year-old student Malala Yousafzai also received a high number of votes in the poll. She received 1,474 votes, putting her in third place. Last year, Yousafzai was injured by the Taliban after becoming an influential voice for education and women's rights in Pakistan. In 2013, Malala became the youngest person ever to be nominated for a Nobel Peace Prize. She also released her memoir, I Am Malala, which tells the story of her life before and after she was attacked.
"A TIME-Honored Tradition"
TFK's Person of the Year announcement follows an 86-year-old tradition started by TIME magazine. At the end of each year, TIME editors recognize the person, group or (sometimes) idea that has influenced events and had the greatest impact on the world for the preceding 12 months.
TIME chose Pope Francis for its 2013 Person of the Year. He is the first Pope from South America and the first non-European pope in 1,300 years. He has spoken out against income inequality and urged followers to fight against poverty. Pope Francis has stirred excitement among followers and brought new energy to the church. As the leader of the world's 1.2 billion Catholics, he has been called a man of the people because of his modest lifestyle. The Pope earned 830 votes in TFK's poll.
Who will become TFK's Person of the Year in 2014? Teaching kids about the people who are changing our world is something TFK aims to do every week. Together, we will watch world events unfold during the year ahead.

subset: commoncrawl


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Discussion in 'Draft Zone' started by Bob Sacamano, Jan 13, 2007.
or at least according to his roommate/closest friend
He's gay?
he might as well be w/ all the man-love he's getting on here
Who is he????
FS from Florida, a First round pick.
Got a link?
That's all we need is a FS with an alternative lifestyle telling Roy, "I've got your back."
Nelson is the real deal, he'll be gone before we pick.
"Meanwhile, there are reports that Florida junior FS Reggie Nelson, who should be one of the first defensive players off the board this spring, has made the decision to enter this year's draft."
- www.gbnreport.com
I think the kid from LSU, Landry is a much better player than this Nelson kid.
i think watkins is good at this moment.
nelson is a first team all-american and kirk herbstreit has said many times that he thinks nelson is the sec mvp. not that what herbstreit says matters or anything but nelson is definitely the real deal
Not based on this past season.
This season it wasn't even close as to who was better.
Also I like Nelsons cover skills much better than I do Landrys.
I'd bet Nelson is the 1st Safety took in this upcoming draft as well.
hmmm i guess the closet got too small for him......so he had to come out


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Hey guys, what is up with these ban type guns? I like the heavy barrel - what is your opinion of the match target? 20" bbl "Colt Match Target Competition" i have badger 1" dia rings on it.
I want to redo the forearm with a floater and put a night force on it and slap a trigger job eventually.. ideas?
Wow this place changed.. nice new look.


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|Data Dictionary:
|Census 1860
you are here: choose a survey survey data set table details
Survey: Census 1860
|Data Source:
|Digitally transcribed by Inter-university Consortium for Political and Social Research. Edited, verified by Michael Haines. Compiled, edited and verified by Social Explorer.
Data set: Social Explorer Dataset (SE)
|T63. Slave Status By Race By Age [98]
Universe: Total Population
Table Details
|Slave Status By Race By Age
|Universe: Total Population
- Male and Female by age group totals are aggregations of Male and Female White, Slaves, Free-Colored, Indian, Asian, and Mixed Indian & White, respectively.
- Counties: St Lawrence, NY, Liberty, GA, Lincoln, GA, Clarke, VA, and Clay, VA has differences between published total population and aggregated table total of less than 1% of total population.
- Counties: Brazoria, TX and Brazos, TX have differences between published total population and aggregated table total of more than 1% of published total population.
- Liberty and Lincoln county, Clarke and Clay county along with Brazoria and Brazos county are consecutive sets of observations and their differences are the same (e.g., Liberty county under counts published total population by 23 while Lincoln over counts by 23).
- Universe and Sub-Universes calculated By SE. Universe now reflects aggregated table total.
- Caution: St. Lawrence County, NY has a total of 2 Indians but did not iterate on their sex, total population for this county is 2 less than its published total.


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Torq Vega
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I currently use a Canon 5dMKIII for all my landscape work and wildlife. Lenses include a Canon 17-40mm f4.0 L, Canon 70-200 f4.0 L and a Canon 400mm f5.6 L. I also use various filters by Hoya and Lee.


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Størrelse16 m²
Etage3(med elevator)
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Anmeldelser af denne værts andre boliger
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Great thanks to Ramon!
I recommend this place. The room was very nice, clean and with aircondition. The breakfast was good. The accommodation is in good place near underground.
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U Xawiera mieszka się bardzo przyjemnie. P O L E C A M!
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Our stay in this apartment was amazing. The room was nice, comfortable and clean. Xavier's cousin - Ramon - was very helpful and sympathetic. We do recomend this place and wish we had stayed longer :) see you soon Barcelona!
The stay with Xavier/Ramon was a wonderful time for us. The rooms were very clean and the host was very helpful and agreable. We will come back as soon as possible.Anne und Heiner
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- Kvalitetssikrede boliger
- Alle værter verificeres via telefon
- Sikker betaling med SSL-kryptering


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Once again, the Board of Supervisors appears to be entertaining a proposal to put a new, 18-acre truck stop at the CR-6 exit off Interstate 5 in Dunnigan.
The problem is, a lot of people in Dunnigan still don't want it there.
The bid to put a Love's Travel Center - including a tire facility, convenience store, McDonald's, Subway and 24 fuel pumps - at that off-ramp came up once before in March. At that time dozens of Dunnigan residents spoke out against the idea, saying they would be happy to have a Love's at the CR-8 off-ramp, but not at CR-6.
"I think Love's is a great operation," said Supervisor Duane Chamberlain at the time. "I just wish you would consider Road 8 and the people up there."
Residents say they have community-centered plans for CR-6, including a school, which are not compatible with a truck stop. Ultimately the board voted down the proposal 4-1, with Supervisor Jim Provenza in favor.
But according to Dunnigan residents, the proposal is bubbling back up, with Provenza reportedly planning to reintroduce it to the board on Dec. 4.
"We thought we had put that to bed," said Roma Gullatt, a Dunnigan resident who sits on the Dunnigan Citizen Advisory Committee. "Needless to say this has taken the community by surprise. Because we thought that was the final vote."
Many residents of this community of about 1,400 say they have plans for the CR-6 location already - a Dunnigan Specific Plan, in fact. "The plan calls for a medical clinic, a grocery store and some other small businesses for the community," Gullatt said.
"The school is supposed to be located next to that (CR-6) property," she added. "And that's what's kind of driving us right to the moon, because who would want a truck stop next to a school?"
She said this plan accounts for Dunnigan's aging population: "Going forward it will be more challenging for them to get those services. So we see the growth of Dunnigan as a requirement if the community is going to survive."
The Dunnigan Specific Plan has not been ratified by the Yolo County Board of Supervisors.
Provenza was not immediately available for comment. In March, however, it was estimated the proposal would bring 25 to 50 jobs to Dunnigan and at least $400,000 into county coffers.
"That's real money that our county needs to go forward," Provenza said at the time. "As you know, we can't afford to do road maintenance. We haven't been able to afford to do some of the basic things that a county does."
"Without jobs," he said, "we're not going to have houses, we're not going to have economic development in Dunnigan, we're not going to have a city in Dunnigan. It's just not going to happen."
He added, "I think this location is the only location that is going to work."
Love's reportedly has shown no interest in CR-8, where another truck stop - Pilot Travel Center - already exists.
"Love's, for whatever reason, does not want to go to 8. They want it at 6," said Patricia Valenzuela, deputy to Supervisor Chamberlain.
Keith Williams, a former member of the Dunnigan Citizen Advisory Committee who now serves on the county's Planning Commission - and was that body's sole vote against putting the truck stop on CR-6 - speculates that Love's does "not want to be adjacent to Pilot on Road 8."
Calls to two Love's company spokeswomen were not returned.
Countrywide, Love's has hundreds of outlets, about 10,000 employees and more than $17 billion in annual revenues, according to the company's website.
Williams said the community is already organizing, and plans to hold a meeting at the Dunnigan firehouse on Wednesday evening.
"It's about as controversial as anything in Dunnigan I've seen since the prison was going in here," he said.
Follow Don Frances at twitter.com/donjfran


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text:
A Strong Voice, A Proven Leader, A True Senator
Thank you for visiting my website. It is an honor and privilege to represent the citizens of Wicomico and Worcester counties as their Delegate in the Maryland General Assembly. To all of you, I extend my heartfelt thanks and deep appreciation for your support.
Now as I campaign for the Maryland state Senate from District 38, I ask for your continued support. This website will provide you with current information about campaign events, news, issues, how to volunteer and contribute. Also, I'll be posting on Facebook, Twitter, Google+ and LinkedIN. I urge you to visit this site and stay connected throughout the campaign.


text:
|Data Dictionary:
|ACS 2009 (1-Year Estimates)
you are here: choose a survey survey data set table details
Survey: ACS 2009 (1-Year Estimates)
|Data Source:
|U.S. Census Bureau
Data set: American Community Survey 2009 (ACS09)
|B25052. Kitchen Facilities For Occupied Housing Units [3]
Universe: Occupied housing units
Table Details
|Kitchen Facilities For Occupied Housing Units
|Universe: Occupied housing units
Relevant Documentation:
|Excerpt from:
|Social Explorer; U.S. Census Bureau; American Community Survey 2009 Summary File: Technical Documentation.
|ACS 2009-1yr Summary File: Technical Documentation -> Appendix A. Supplemental Documentation -> 2009 Subject Definitions -> Housing Variables -> Kitchen Facilities
Data on kitchen facilities were obtained from Housing Question 8d-f in the 2009 American Community Survey. The question was asked at both occupied and vacant housing units. A unit has complete kitchen facilities when it has all three of the following facilities: (d) a sink with a faucet, (e) a stove or range, and (f) a refrigerator. All kitchen facilities must be located in the house, apartment, or mobile home, but they need not be in the same room. A housing unit having only a microwave or portable heating equipment such as a hot plate or camping stove should not be considered as having complete kitchen facilities. An icebox is not considered to be a refrigerator. Kitchen facilities provide an indication of living standards and assess the quality of household facilities within the housing inventory. These data provide assistance in determining areas that are eligible for programs and funding, such as Meals on Wheels. The data also serve to aid in the development of policies based on fair market rent, and to identify areas in need of rehabilitation loans or grants.
Question/Concept History
The 1996-1998 American Community Survey questions asked whether the house or apartment had complete kitchen facilities, requiring that the three facilities all be in the same unit. In 1999, "mobile home" was added to the question, along with the capitalization of the word "COMPLETE" for emphasis. Starting in 2008, the structure of the question changed and combined kitchen facilities with plumbing facilities and telephone service availability into one question to ask, "Does this house, apartment, or mobile home have-" and provided the respondent with a "Yes" or "No" checkbox for each component needed for complete facilities. Also in 2008, the component "sink with piped water" was changed to "sink with a faucet."
Caution should be used when comparing American Community Survey data on kitchen facilities from the years 2008 and after with both pre-2008 ACS and Census 2000 data. Changes made to the kitchen facilities question between the 2007 and 2008 ACS involving the wording, the response option, and translation to the Spanish questionnaire resulted in an inconsistency in the ACS data. This inconsistency in the data was most noticeable as an increase in housing units "lacking complete kitchen facilities."
|Excerpt from:
|Social Explorer; U.S. Census Bureau; American Community Survey 2009 Summary File: Technical Documentation.
|ACS 2009-1yr Summary File: Technical Documentation -> Appendix A. Supplemental Documentation -> 2009 Subject Definitions -> Living Quarters -> Housing Unit -> Occupied Housing Unit
A housing unit is classified as occupied if it is the current place of residence of the person or group of people living in it at the time of interview, or if the occupants are only temporarily absent from the residence for two months or less, that is, away on vacation or a business trip. If all the people staying in the unit at the time of the interview are staying there for two months or less, the unit is considered to be temporarily occupied and classified as "vacant." The occupants may be a single family, one person living alone, two or more families living together, or any other group of related or unrelated people who share living quarters. The living quarters occupied by staff personnel within any group quarters are separate housing units if they satisfy the housing unit criteria of separateness and direct access; otherwise, they are considered group quarters. Occupied rooms or suites of rooms in hotels, motels, and similar places are classified as housing units only when occupied by permanent residents, that is, people who consider the hotel as their current place of residence or have no current place of residence elsewhere. If any of the occupants in rooming or boarding houses, congregate housing, or continuing care facilities live separately from others in the building and have direct access, their quarters are classified as separate housing units.


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Kevin Breel:
Confessions of a depressed comic
Kevin Breel didn't look like a depressed kid: team captain, at every party, funny and confident. But he tells the story of the night he realized that — to save his own life — he needed to say four simple words.
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This talk was presented to a local audience at TEDxKids@Ambleside, an independent event. TED editors featured it among our selections on the home page.
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The Learning Assistance Center (LAC) provides support services to facilitate learning. The LAC has two main purposes: tutoring and disability services.
Our tutoring services include subject specific tutoring, study skills assistance, study groups, and Supplemental Instruction (SI). For students with documented disabilities, our disability services provides accommodations such as extended time on exams, reduced distraction testing environment, note-taking assistance, and assistive technology. We provide these services in a positive and encouraging environment which promotes appreciation for diversity and Cura Personalis.
The Learning Assistance Center is located on the fifth floor of the Conaton Learning Commons, Suite 514.


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SILVER SONIC high performance audio cables were designed to provide the highest level of sound quality possible. By combining the finest materials available in electrically efficient, noise canceling geometries, Silver Sonic cables are the most transparent way of carrying musical signals between audio components. Manufactured in the USA, SILVER SONIC audio cables utilize a synergistic combination of silver and oxygen free copper conductors, advanced dielectrics, and vibration damping materials for superior performance.


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[Date Prev][Date Next][Thread Prev][Thread Next][Date index][Thread index]
st: return results from dstdize
"West Joe" <email@example.com>
st: return results from dstdize
Tue, 13 Nov 2007 09:03:50 -0000
I have carried out my dstdize command but would like to get hold of the
standard errors of the adjusted rates, either displayed or saved. I am
using version 9.2. I have tried
dstdize ndths pops agegrp, by(year) using(european_pop.dta)
return list
The standardisation goes ok but the returned results look like the
output below. I was expecting the r(se) matrix to be a macro, and to be
the standard error I am looking for, according to the online help but it
seems not to be the case. I am assuming I have done something wrong but
can't figure it out.
Any advice would be gratefully received.
Joe West
r(k) = 5
r(by) : "year"
r(c5) : "`"2005"'"
r(c4) : "`"2004"'"
r(c3) : "`"2003"'"
r(c2) : "`"2002"'"
r(c1) : "`"2001"'"
r(se) : 1 x 5
r(ub) : 1 x 5
r(lb) : 1 x 5
r(adj) : 1 x 5
r(crude) : 1 x 5
r(Nobs) : 1 x 5
This message has been checked for viruses but the contents of an attachment
may still contain software viruses, which could damage your computer system:
you are advised to perform your own checks. Email communications with the
University of Nottingham may be monitored as permitted by UK legislation.
* For searches and help try:
* http://www.stata.com/support/faqs/res/findit.html
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text:
I am looking to get a Kubota Tractor L3800 HST with a loader on it with quick attach for Forks tires loaded with Cal. I haven't gone to look at it yet , they are 23,400 +tx with leasing options.
Do any of you have experience in using tractors for moving 4 way pallets ?
Is this going to be a bouncy thing ? The Kubota guys tell me if I lock the cruise on in low gear , it will crawl along and I won't have the jerky movements when going over rough terrain.
Ben L


text:
This is my eleventh week working out with Simplefit , so I thought I should post something.
I am a 74 year old male, with two exceptions in good health. Exceptions COPD, smoked for 45 years, and MS , which is only a problem during a relapse,
I have been working out fairly regularly for 10 years. Main problem is no wind.
I am 5' 8" tall, weigh about 168 pounds, down from 194 a year ago, an plan to lose about 13 more pounds.
Week Level Day One Day Two Day Three
Rounds Time Time
One One 30 4:06 1:29
Two Two 22 4:33 2:05
Three Three 26 4:43 2:32
Four One(R) 30 3:12 1:26
Five Three* 25 5:35 1:50
Six Four 21 5:31 3:38
Seven Four** 22 5:28 3:16
Eight Three(R) 25 4:42 2:08
Nine Five 14 6:12 4:41
Ten Six 20 7:13 6:20
Eleven Six 22 6:38 5:05
Comments * repeated Level three because as I was not happy with my form.
** repeated level four as I had to rest during push ups on day three.
Thought if I can't do 41 I sure won't do 51 next week.
(R) Rest week
I wish I could say all Pull-ups are dead hang but after 12 or 13 there is a lot of kipping. Form on Push ups are ok,
I am sure I cheat a little on range of motion to increase speed.
This was to be in tab form but it's readable. Sorry about that


text:
Antibiotics Aren't Always the Answer »
"Antibiotics do not fight infections caused by viruses like colds, flu, most sore throats, bronchitis, and many sinus and ear infections. Instead, symptom relief might be the best treatment option for viral infections.
Get smart about when a"...
(See also BOXED WARNING)
All Patients
Cyclosporine, the active ingredient of Neoral®, can cause nephrotoxicity and hepatotoxicity. The risk increases with increasing doses of cyclosporine. Renal dysfunction including structural kidney damage is a potential consequence of Neoral® and therefore renal function must be monitored during therapy. Care should be taken in using cyclosporine with nephrotoxic drugs. (See PRECAUTIONS)
Patients receiving Neoral® require frequent monitoring of serum creatinine. (See Special Monitoring under DOSAGE AND ADMINISTRATION) Elderly patients should be monitored with particular care, since decreases in renal function also occur with age. If patients are not properly monitored and doses are not properly adjusted, cyclosporine therapy can be associated with the occurrence of structural kidney damage and persistent renal dysfunction.
An increase in serum creatinine and BUN may occur during Neoral® therapy and reflect a reduction in the glomerular filtration rate. Impaired renal function at any time requires close monitoring, and frequent dosage adjustment may be indicated. The frequency and severity of serum creatinine elevations increase with dose and duration of cyclosporine therapy. These elevations are likely to become more pronounced without dose reduction or discontinuation.
Because Neoral® is not bioequivalent to Sandimmune®, conversion from Neoral® to Sandimmune® using a 1:1 ratio (mg/kg/day) may result in lower cyclosporine blood concentrations. Conversion from Neoral® to Sandimmune® should be made with increased monitoring to avoid the potential of underdosing.
Kidney, Liver, and Heart Transplant
Cyclosporine, the active ingredient of Neoral®, can cause nephrotoxicity and hepatotoxicity when used in high doses. It is not unusual for serum creatinine and BUN levels to be elevated during cyclosporine therapy. These elevations in renal transplant patients do not necessarily indicate rejection, and each patient must be fully evaluated before dosage adjustment is initiated.
Based on the historical Sandimmune® experience with oral solution, nephrotoxicity associated with cyclosporine had been noted in 25% of cases of renal transplantation, 38% of cases of cardiac transplantation, and 37% of cases of liver transplantation. Mild nephrotoxicity was generally noted 2-3 months after renal transplant and consisted of an arrest in the fall of the pre-operative elevations of BUN and creatinine at a range of 35-45 mg/dl and 2.0-2.5 mg/dl respectively. These elevations were often responsive to cyclosporine dosage reduction.
More overt nephrotoxicity was seen early after transplantation and was characterized by a rapidly rising BUN and creatinine. Since these events are similar to renal rejection episodes, care must be taken to differentiate between them. This form of nephrotoxicity is usually responsive to cyclosporine dosage reduction.
Although specific diagnostic criteria which reliably differentiate renal graft rejection from drug toxicity have not been found, a number of parameters have been significantly associated with one or the other. It should be noted however, that up to 20% of patients may have simultaneous nephrotoxicity and rejection.
|Nephrotoxicity vs. Rejection
|Donor > 50 years old or hypotensive Prolonged kidney preservation
Prolonged anastomosis time
Concomitant nephrotoxic drugs
|Anti-donor immune response
Retransplant patient
|Often > 6 weeks postopb
Prolonged initial nonfunction (acute tubular necrosis)
|Often < 4 weeks postopb
Fever > 37.5°C
Weight gain > 0.5 kg
Graft swelling and tenderness
Decrease in daily urine volume > 500 mL (or 50%)
|CyA serum trough level > 200 ng/mL Gradual rise in Cr ( < 0.15 mg/dl/day)a
Cr plateau < 25% above baseline
BUN/Cr > 20
|CyA serum trough level < 150 ng/mL Rapid rise in Cr ( > 0.3 mg/dl/day)a
Cr > 25% above baseline
BUN/Cr < 20
|Arteriolopathy (medial hypertrophya, hyalinosis, nodular deposits, intimal thickening, endothelial vacuolization, progressive scarring)
Tubular atrophy, isometric vacuolization, isolated calcifications
Minimal edema
Mild focal infiltratesc
|Endovasculitisc (proliferationa, intimal arteritisb, necrosis, sclerosis)
Tubulitis with RBCb and WBCb casts, some irregular vacuolization
Interstitial edemac and hemorrhageb
Diffuse moderate to severe mononuclear infiltratesd
Glomerulitis (mononuclear cells)c
|Aspiration Cytology
|Diffuse interstitial fibrosis, often striped form
CyA deposits in tubular and endothelial cells
Fine isometric vacuolization of tubular cells
|Inflammatory infiltrate with mononuclear phagocytes, macrophages, lymphoblastoid cells, and activated T-cells
These strongly express HLA-DR antigens
|Urine Cytology
|Tubular cells with vacuolization and granularization
|Degenerative tubular cells, plasma cells, and lymphocyturia > 20% of sediment
|Manometry Ultrasonography
|Intracapsular pressure < 40 mm Hgb Unchanged graft cross sectional area
|Intracapsular pressure > 40 mm Hgb Increase in graft cross sectional area AP diameter ≥ Transverse diameter
|Magnetic Resonance Imagery
|Normal appearance
|Loss of distinct corticomedullary junction, swelling image intensity of parachyma approaching that of psoas, loss of hilar fat
|Radionuclide Scan
|Normal or generally decreased perfusion Decrease in tubular function (131 I-hippuran) > decrease in perfusion (99m Tc DTPA)
|Patchy arterial flow
Decrease in perfusion > decrease in tubular function Increased uptake of Indium 111 labeled platelets or Tc-99m in colloid
|Responds to decreased cyclosporine
|Responds to increased steroids or antilymphocyte globulin
|ap < 0.05,
bp < 0.01,
cp < 0.001,
dp < 0.0001
A form of a cyclosporine-associated nephropathy is characterized by serial deterioration in renal function and morphologic changes in the kidneys. From 5%-15% of transplant recipients who have received cyclosporine will fail to show a reduction in rising serum creatinine despite a decrease or discontinuation of cyclosporine therapy. Renal biopsies from these patients will demonstrate one or several of the following alterations: tubular vacuolization, tubular microcalcifications, peritubular capillary congestion, arteriolopathy, and a striped form of interstitial fibrosis with tubular atrophy. Though none of these morphologic changes is entirely specific, a diagnosis of cyclosporine-associated structural nephrotoxicity requires evidence of these findings.
When considering the development of cyclosporine-associated nephropathy, it is noteworthy that several authors have reported an association between the appearance of interstitial fibrosis and higher cumulative doses or persistently high circulating trough levels of cyclosporine. This is particularly true during the first 6 post-transplant months when the dosage tends to be highest and when, in kidney recipients, the organ appears to be most vulnerable to the toxic effects of cyclosporine. Among other contributing factors to the development of interstitial fibrosis in these patients are prolonged perfusion time, warm ischemia time, as well as episodes of acute toxicity, and acute and chronic rejection. The reversibility of interstitial fibrosis and its correlation to renal function have not yet been determined. Reversibility of arteriolopathy has been reported after stopping cyclosporine or lowering the dosage.
Impaired renal function at any time requires close monitoring, and frequent dosage adjustment may be indicated.
In the event of severe and unremitting rejection, when rescue therapy with pulse steroids and monoclonal antibodies fail to reverse the rejection episode, it may be preferable to switch to alternative immunosuppressive therapy rather than increase the Neoral® dose to excessive levels.
Thrombotic Microangiopathy
Occasionally patients have developed a syndrome of thrombocytopenia and microangiopathic hemolytic anemia which may result in graft failure. The vasculopathy can occur in the absence of rejection and is accompanied by avid platelet consumption within the graft as demonstrated by Indium 111 labeled platelet studies. Neither the pathogenesis nor the management of this syndrome is clear. Though resolution has occurred after reduction or discontinuation of cyclosporine and 1) administration of streptokinase and heparin or 2) plasmapheresis, this appears to depend upon early detection with Indium 111 labeled platelet scans. (See ADVERSE REACTIONS)
Significant hyperkalemia (sometimes associated with hyperchloremic metabolic acidosis) and hyperuricemia have been seen occasionally in individual patients.
Cases of hepatotoxicity and liver injury including cholestasis, jaundice, hepatitis, and liver failure have been reported in patients treated with cyclosporine. Most reports included patients with significant comorbidities, underlying conditions and other confounding factors including infectious complications and comedications with hepatotoxic potential. In some cases, mainly in transplant patients, fatal outcomes have been reported (see ADVERSE REACTIONS, Postmarketing Experience, Kidney, Liver and Heart Transplantation).
Hepatotoxicity, usually manifested by elevations in hepatic enzymes and bilirubin, was reported in patients treated with cyclosporine in clinical trials: 4% in renal transplantation, 7% in cardiac transplantation, and 4% in liver transplantation. This was usually noted during the first month of therapy when high doses of cyclosporine were used. The chemistry elevations usually decreased with a reduction in dosage.
As in patients receiving other immunosuppressants, those patients receiving cyclosporine are at increased risk for development of lymphomas and other malignancies, particularly those of the skin. Patients taking cyclosporine should be warned to avoid excess ultraviolet light exposure. The increased risk appears related to the intensity and duration of immunosuppression rather than to the use of specific agents. Because of the danger of oversuppression of the immune system resulting in increased risk of infection or malignancy, a treatment regimen containing multiple immunosuppressants should be used with caution. Some malignancies may be fatal. Transplant patients receiving cyclosporine are at increased risk for serious infection with fatal outcome.
Serious Infections
Patients receiving immunosuppressants, including Neoral, are at increased risk of developing bacterial, viral, fungal, and protozoal infections, including opportunistic infections. These infections may lead to serious, including fatal, outcomes [See BOXED WARNING, and ADVERSE REACTIONS].
Polyomavirus Infections
Patients receiving immunosuppressants, including Neoral, are at increased risk for opportunistic infections, including polyomavirus infections. Polyoma virus infections in transplant patients may have serious, and sometimes, fatal outcomes. These include cases of JC virus-associated progressive multifocal leukoencephalopathy (PML), and polyoma virus-associated nephropathy (PVAN), especially due to BK virus infection, which have been observed in patients receiving cyclosporine.
PVAN is associated with serious outcomes, including deteriorating renal function and renal graft loss, (see ADVERSE REACTIONS/Postmarketing Experience, Kidney, Liver and Heart Transplantation). Patient monitoring may help detect patients at risk for PVAN.
Cases of PML have been reported in patients treated with Neoral. PML, which is sometimes fatal, commonly presents with hemiparesis, apathy, confusion, cognitive deficiencies and ataxia. Risk factors for PML include treatment with immunosuppressant therapies and impairment of immune function. In immunosuppressed patients, physicians should consider PML in the differential diagnosis in patients reporting neurological symptoms and consultation with a neurologist should be considered as clinically indicated.
Consideration should be given to reducing the total immunosuppression in transplant patients who develop PML or PVAN. However, reduced immunosuppression may place the graft at risk.
There have been reports of convulsions in adult and pediatric patients receiving cyclosporine, particularly in combination with high dose methylprednisolone.
Encephalopathy has been described both in post-marketing reports and in the literature. Manifestations include impaired consciousness, convulsions, visual disturbances (including blindness), loss of motor function, movement disorders and psychiatric disturbances. In many cases, changes in the white matter have been detected using imaging techniques and pathologic specimens. Predisposing factors such as hypertension, hypomagnesemia, hypocholesterolemia, high-dose corticosteroids, high cyclosporine blood concentrations, and graft-versus-host disease have been noted in many but not all of the reported cases. The changes in most cases have been reversible upon discontinuation of cyclosporine, and in some cases improvement was noted after reduction of dose. It appears that patients receiving liver transplant are more susceptible to encephalopathy than those receiving kidney transplant. Another rare manifestation of cyclosporine-induced neurotoxicity, occurring in transplant patients more frequently than in other indications, is optic disc edema including papilloedema, with possible visual impairment, secondary to benign intracranial hypertension.
Care should be taken in using cyclosporine with nephrotoxic drugs. (See PRECAUTIONS)
Rheumatoid Arthritis
Cyclosporine nephropathy was detected in renal biopsies of 6 out of 60 (10%) rheumatoid arthritis patients after the average treatment duration of 19 months. Only one patient, out of these 6 patients, was treated with a dose ≤ 4 mg/kg/day. Serum creatinine improved in all but one patient after discontinuation of cyclosporine. The "maximal creatinine increase" appears to be a factor in predicting cyclosporine nephropathy.
There is a potential, as with other immunosuppressive agents, for an increase in the occurrence of malignant lymphomas with cyclosporine. It is not clear whether the risk with cyclosporine is greater than that in rheumatoid arthritis patients or in rheumatoid arthritis patients on cytotoxic treatment for this indication. Five cases of lymphoma were detected: four in a survey of approximately 2,300 patients treated with cyclosporine for rheumatoid arthritis, and another case of lymphoma was reported in a clinical trial. Although other tumors (12 skin cancers, 24 solid tumors of diverse types, and 1 multiple myeloma) were also reported in this survey, epidemiologic analyses did not support a relationship to cyclosporine other than for malignant lymphomas.
Patients should be thoroughly evaluated before and during Neoral® treatment for the development of malignancies. Moreover, use of Neoral® therapy with other immunosuppressive agents may induce an excessive immunosuppression which is known to increase the risk of malignancy.
(See also BOXED WARNINGS for Psoriasis)
Since cyclosporine is a potent immunosuppressive agent with a number of potentially serious side effects, the risks and benefits of using Neoral® should be considered before treatment of patients with psoriasis. Cyclosporine, the active ingredient in Neoral®, can cause nephrotoxicity and hypertension (see PRECAUTIONS) and the risk increases with increasing dose and duration of therapy. Patients who may be at increased risk such as those with abnormal renal function, uncontrolled hypertension or malignancies, should not receive Neoral®.
Renal dysfunction is a potential consequence of Neoral® therefore renal function must be monitored during therapy.
Patients receiving Neoral® require frequent monitoring of serum creatinine. (See Special Monitoring under DOSAGE AND ADMINISTRATION) Elderly patients should be monitored with particular care, since decreases in renal function also occur with age. If patients are not properly monitored and doses are not properly adjusted, cyclosporine therapy can cause structural kidney damage and persistent renal dysfunction.
An increase in serum creatinine and BUN may occur during Neoral® therapy and reflects a reduction in the glomerular filtration rate.
Kidney biopsies from 86 psoriasis patients treated for a mean duration of 23 months with 1.2-7.6 mg/kg/day of cyclosporine showed evidence of cyclosporine nephropathy in 18/86 (21%) of the patients. The pathology consisted of renal tubular atrophy and interstitial fibrosis. On repeat biopsy of 13 of these patients maintained on various dosages of cyclosporine for a mean of 2 additional years, the number with cyclosporine induced nephropathy rose to 26/86 (30%). The majority of patients (19/26) were on a dose of ≥ 5.0 mg/kg/day (the highest recommended dose is 4 mg/kg/day). The patients were also on cyclosporine for greater than 15 months (18/26) and/or had a clinically significant increase in serum creatinine for greater than 1 month (21/26). Creatinine levels returned to normal range in 7 of 11 patients in whom cyclosporine therapy was discontinued.
There is an increased risk for the development of skin and lymphoproliferative malignancies in cyclosporine-treated psoriasis patients. The relative risk of malignancies is comparable to that observed in psoriasis patients treated with other immunosuppressive agents.
Tumors were reported in 32 (2.2%) of 1439 psoriasis patients treated with cyclosporine worldwide from clinical trials. Additional tumors have been reported in 7 patients in cyclosporine postmarketing experience. Skin malignancies were reported in 16 (1.1%) of these patients; all but 2 of them had previously received PUVA therapy. Methotrexate was received by 7 patients. UVB and coal tar had been used by 2 and 3 patients, respectively. Seven patients had either a history of previous skin cancer or a potentially predisposing lesion was present prior to cyclosporine exposure. Of the 16 patients with skin cancer, 11 patients had 18 squamous cell carcinomas and 7 patients had 10 basal cell carcinomas.
There were two lymphoproliferative malignancies; one case of non-Hodgkin's lymphoma which required chemotherapy, and one case of mycosis fungoides which regressed spontaneously upon discontinuation of cyclosporine. There were four cases of benign lymphocytic infiltration: 3 regressed spontaneously upon discontinuation of cyclosporine, while the fourth regressed despite continuation of the drug. The remainder of the malignancies, 13 cases (0.9%), involved various organs.
Patients should not be treated concurrently with cyclosporine and PUVA or UVB, other radiation therapy, or other immunosuppressive agents, because of the possibility of excessive immunosuppression and the subsequent risk of malignancies. (See CONTRAINDICATIONS) Patients should also be warned to protect themselves appropriately when in the sun, and to avoid excessive sun exposure. Patients should be thoroughly evaluated before and during treatment for the presence of malignancies remembering that malignant lesions may be hidden by psoriatic plaques. Skin lesions not typical of psoriasis should be biopsied before starting treatment. Patients should be treated with Neoral® only after complete resolution of suspicious lesions, and only if there are no other treatment options. (See Special Monitoring for Psoriasis Patients)
Cyclosporine is the active ingredient of Neoral®. Hypertension is a common side effect of cyclosporine therapy which may persist. (See ADVERSE REACTIONS and DOSAGE AND ADMINISTRATION for monitoring recommendations) Mild or moderate hypertension is encountered more frequently than severe hypertension and the incidence decreases over time. In recipients of kidney, liver, and heart allografts treated with cyclosporine, antihypertensive therapy may be required. (See Special Monitoring of Rheumatoid Arthritis and Psoriasis Patients) However, since cyclosporine may cause hyperkalemia, potassium-sparing diuretics should not be used. While calcium antagonists can be effective agents in treating cyclosporine-associated hypertension, they can interfere with cyclosporine metabolism. (See DRUG INTERACTIONS)
During treatment with cyclosporine, vaccination may be less effective; and the use of live attenuated vaccines should be avoided.
Special Monitoring of Rheumatoid Arthritis Patients
Before initiating treatment, a careful physical examination, including blood pressure measurements (on at least two occasions) and two creatinine levels to estimate baseline should be performed. Blood pressure and serum creatinine should be evaluated every 2 weeks during the initial 3 months and then monthly if the patient is stable. It is advisable to monitor serum creatinine and blood pressure always after an increase of the dose of nonsteroidal anti-inflammatory drugs and after initiation of new nonsteroidal anti-inflammatory drug therapy during Neoral® treatment. If co-administered with methotrexate, CBC and liver function tests are recommended to be monitored monthly. (See also PRECAUTIONS, General, Hypertension)
In patients who are receiving cyclosporine, the dose of Neoral® should be decreased by 25%-50% if hypertension occurs. If hypertension persists, the dose of Neoral® should be further reduced or blood pressure should be controlled with antihypertensive agents. In most cases, blood pressure has returned to baseline when cyclosporine was discontinued.
In placebo-controlled trials of rheumatoid arthritis patients, systolic hypertension (defined as an occurrence of two systolic blood pressure readings > 140 mmHg) and diastolic hypertension (defined as two diastolic blood pressure readings > 90 mmHg) occurred in 33% and 19% of patients treated with cyclosporine, respectively. The corresponding placebo rates were 22% and 8%.
Special Monitoring for Psoriasis Patients
Before initiating treatment, a careful dermatological and physical examination, including blood pressure measurements (on at least two occasions) should be performed. Since Neoral® is an immunosuppressive agent, patients should be evaluated for the presence of occult infection on their first physical examination and for the presence of tumors initially, and throughout treatment with Neoral®. Skin lesions not typical for psoriasis should be biopsied before starting Neoral®. Patients with malignant or premalignant changes of the skin should be treated with Neoral® only after appropriate treatment of such lesions and if no other treatment option exists.
Baseline laboratories should include serum creatinine (on two occasions), BUN, CBC, serum magnesium, potassium, uric acid, and lipids.
The risk of cyclosporine nephropathy is reduced when the starting dose is low (2.5 mg/kg/day), the maximum dose does not exceed 4.0 mg/kg/day, serum creatinine is monitored regularly while cyclosporine is administered, and the dose of Neoral® is decreased when the rise in creatinine is greater than or equal to 25% above the patient's pretreatment level. The increase in creatinine is generally reversible upon timely decrease of the dose of Neoral® or its discontinuation.
Serum creatinine and BUN should be evaluated every 2 weeks during the initial 3 months of therapy and then monthly if the patient is stable. If the serum creatinine is greater than or equal to 25% above the patient's pretreatment level, serum creatinine should be repeated within two weeks. If the change in serum creatinine remains greater than or equal to 25% above baseline, Neoral® should be reduced by 25%-50%. If at any time the serum creatinine increases by greater than or equal to 50% above pretreatment level, Neoral® should be reduced by 25%-50%. Neoral® should be discontinued if reversibility (within 25% of baseline) of serum creatinine is not achievable after two dosage modifications. It is advisable to monitor serum creatinine after an increase of the dose of nonsteroidal anti-inflammatory drug and after initiation of new nonsteroidal anti-inflammatory therapy during Neoral® treatment.
Blood pressure should be evaluated every 2 weeks during the initial 3 months of therapy and then monthly if the patient is stable, or more frequently when dosage adjustments are made. Patients without a history of previous hypertension before initiation of treatment with Neoral®, should have the drug reduced by 25%-50% if found to have sustained hypertension. If the patient continues to be hypertensive despite multiple reductions of Neoral®, then Neoral® should be discontinued. For patients with treated hypertension, before the initiation of Neoral® therapy, their medication should be adjusted to control hypertension while on Neoral®. Neoral® should be discontinued if a change in hypertension management is not effective or tolerable.
CBC, uric acid, potassium, lipids, and magnesium should also be monitored every 2 weeks for the first 3 months of therapy, and then monthly if the patient is stable or more frequently when dosage adjustments are made. Neoral® dosage should be reduced by 25%-50% for any abnormality of clinical concern.
In controlled trials of cyclosporine in psoriasis patients, cyclosporine blood concentrations did not correlate well with either improvement or with side effects such as renal dysfunction.
Laboratory Tests
In all patients treated with cyclosporine, renal and liver functions should be assessed repeatedly by measurement of serum creatinine, BUN, serum bilirubin, and liver enzymes. Serum lipids, magnesium, and potassium should also be monitored. Cyclosporine blood concentrations should be routinely monitored in transplant patients (see DOSAGE AND ADMINISTRATION, Blood Concentration Monitoring in Transplant Patients), and periodically monitored in rheumatoid arthritis patients.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Carcinogenicity studies were carried out in male and female rats and mice. In the 78-week mouse study, evidence of a statistically significant trend was found for lymphocytic lymphomas in females, and the incidence of hepatocellular carcinomas in mid-dose males significantly exceeded the control value. In the 24-month rat study, pancreatic islet cell adenomas significantly exceeded the control rate in the low dose level. Doses used in the mouse and rat studies were 0.01 to 0.16 times the clinical maintenance dose (6 mg/kg). The hepatocellular carcinomas and pancreatic islet cell adenomas were not dose related. Published reports indicate that co-treatment of hairless mice with UV irradiation and cyclosporine or other immunosuppressive agents shorten the time to skin tumor formation compared to UV irradiation alone.
Cyclosporine was not mutagenic in appropriate test systems. Cyclosporine has not been found to be mutagenic/genotoxic in the Ames Test, the V79-HGPRT Test, the micronucleus test in mice and Chinese hamsters, the chromosome-aberration tests in Chinese hamster bone-marrow, the mouse dominant lethal assay, and the DNA-repair test in sperm from treated mice. A recent study analyzing sister chromatid exchange (SCE) induction by cyclosporine using human lymphocytes in vitro gave indication of a positive effect (i.e., induction of SCE), at high concentrations in this system. In two published research studies, rabbits exposed to cyclosporine in utero (10 mg/kg/day subcutaneously) demonstrated reduced numbers of nephrons, renal hypertrophy, systemic hypertension and progressive renal insufficiency up to 35 weeks of age. Pregnant rats which received 12 mg/kg/day of cyclosporine intravenously (twice the recommended human intravenous dose) had fetuses with an increased incidence of ventricular septal defect. These findings have not been demonstrated in other species and their relevance for humans is unknown.
No impairment in fertility was demonstrated in studies in male and female rats.
Widely distributed papillomatosis of the skin was observed after chronic treatment of dogs with cyclosporine at 9 times the human initial psoriasis treatment dose of 2.5 mg/kg, where doses are expressed on a body surface area basis. This papillomatosis showed a spontaneous regression upon discontinuation of cyclosporine.
An increased incidence of malignancy is a recognized complication of immunosuppression in recipients of organ transplants and patients with rheumatoid arthritis and psoriasis. The most common forms of neoplasms are non-Hodgkin's lymphoma and carcinomas of the skin. The risk of malignancies in cyclosporine recipients is higher than in the normal, healthy population but similar to that in patients receiving other immunosuppressive therapies. Reduction or discontinuance of immunosuppression may cause the lesions to regress.
In psoriasis patients on cyclosporine, development of malignancies, especially those of the skin has been reported. (See WARNINGS) Skin lesions not typical for psoriasis should be biopsied before starting cyclosporine treatment. Patients with malignant or premalignant changes of the skin should be treated with cyclosporine only after appropriate treatment of such lesions and if no other treatment option exists.
Pregnancy Category C
Animal studies have shown reproductive toxicity in rats and rabbits. Cyclosporine gave no evidence of mutagenic or teratogenic effects in the standard test systems with oral application (rats up to 17 mg/kg and rabbits up to 30 mg/kg per day orally.) Only at dose levels toxic to dams, were adverse effects seen in reproduction studies in rats. Cyclosporine has been shown to be embryo- and fetotoxic in rats and rabbits following oral administration at maternally toxic doses. Fetal toxicity was noted in rats at 0.8 and rabbits at 5.4 times the transplant doses in humans of 6.0 mg/kg, where dose corrections are based on body surface area. Cyclosporine was embryo- and fetotoxic as indicated by increased pre- and postnatal mortality and reduced fetal weight together with related skeletal retardation.
There are no adequate and well-controlled studies in pregnant women therefore, Neoral® should not be used during pregnancy unless the potential benefit to the mother justifies the potential risk to the fetus.
In pregnant transplant recipients who are being treated with immunosuppressants the risk of premature birth is increased. The following data represent the reported outcomes of 116 pregnancies in women receiving cyclosporine during pregnancy, 90% of whom were transplant patients, and most of whom received cyclosporine throughout the entire gestational period. The only consistent patterns of abnormality were premature birth (gestational period of 28 to 36 weeks) and low birth weight for gestational age. Sixteen fetal losses occurred. Most of the pregnancies (85 of 100) were complicated by disorders; including, pre-eclampsia, eclampsia, premature labor, abruptio placentae, oligohydramnios, Rh incompatibility, and fetoplacental dysfunction. Pre-term delivery occurred in 47%. Seven malformations were reported in 5 viable infants and in 2 cases of fetal loss. Twenty-eight percent of the infants were small for gestational age. Neonatal complications occurred in 27%. Therefore, the risks and benefits of using Neoral® during pregnancy should be carefully weighed.
A limited number of observations in children exposed to cyclosporine in utero are available, up to an age of approximately 7 years. Renal function and blood pressure in these children were normal.
Because of the possible disruption of maternal-fetal interaction, the risk/benefit ratio of using Neoral® in psoriasis patients during pregnancy should carefully be weighed with serious consideration for discontinuation of Neoral®.
Nursing Mothers
Cyclosporine passes into breast milk. Mothers receiving treatment with Neoral® should not breast-feed.
Pediatric Use
Although no adequate and well-controlled studies have been completed in children, transplant recipients as young as one year of age have received Neoral® with no unusual adverse effects. The safety and efficacy of Neoral® treatment in children with juvenile rheumatoid arthritis or psoriasis below the age of 18 have not been established.
Geriatric Use
In rheumatoid arthritis clinical trials with cyclosporine, 17.5% of patients were age 65 or older. These patients were more likely to develop systolic hypertension on therapy, and more likely to show serum creatinine rises ≥ 50% above the baseline after 3-4 months of therapy.
Clinical studies of Neoral® in transplant and psoriasis patients did not include a sufficient number of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experiences have not identified differences in response between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 11/22/2016
Neoral FDA Prescribing Information
Additional Neoral Information
Neoral - User Reviews
Neoral User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Neoral sorted by most helpful.
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text: Florida Notary Supplies The National Notary Association is the nation's #1 provider of Notary supplies. Get the Full Florida Notary Supply PackageGet your supplies and more when you get your commission from the NNA BECOME a NotaryRENEW a Notary All you need to perform your notarial duties Every professional tool needed by Notaries to perform or prepare for their official duties, including all requirements of state law, is provided by the NNA — a range of choices for the industry's highest quality support materials. Florida Jurat Stamp Compliant with Notary law, this stamp can be used in place of a loose certificate. Not intended for use as a Notary seal. $39 Add to Cart Portable Desk Notary Seal Embosser Easier to use than hand-held embossers with a handle that folds for convenient storage. This portable desk embosser provides clear, crisp seal embossments every time! $36 Details Shop All Florida Notary Supplies Stamps & Embossers Notary Journals Notary Certificates Notary Handbooks Notary Books Security & Privacy Business Supplies NNA Branded Products


text:
Yesterday (7/221/13) My boyfriend and I went to check our four hives only to discover that two of them were all gone with only a few bees and a queen remaining.
A little background information regarding the hives and their conditions a month ago. As stated above we have four hives known as "the big hive", "the weak hive", "the split hive" and "the new hive".
The "big hive" was originally a package of bees purchased from Beeweaver in April of 2012 and was our first hive. As of a month ago, this hive was strong and healthy with one deep hive body, two honey supers and packed full of bees.
The "weak hive" is a combination of two hives of bees that we trapped out last year. Neither hive was doing well so we combined them using the newspaper method in August of 2012. By this spring they were doing very well. Even though we still refer to it as the "weak hive" it is our second largest hive. The hive consists of one hive body and two honey supers.
The "split hive" is a split we took off the "big hive" in April of this year. As of last month they were also doing well. It consists of one hive body.
The "new hive" is a package of bees we purchased April of this year from Beeweaver and they also were also strong and healthy, quickly doubling in their numbers. It consists of one hive body.
Back to my original story, when we checked the bees yesterday, the "big hive" and the "split hive" were both gone (remember the split originally came from the big hive). The "split hive" has about 1 1/2 frames worth of bees left and the queen. The "big hive" has 2 to 3 frames of bees left and their queen. In both hives the remaining bees appear healthy from all appearances. Both hives have eggs, larvae, capped brood, pollen and honey. The "split hive" did have a lot of small hive beetles but we figure that would be normal since there aren't enough bees remaining in the hive to control their numbers. We also found one wax moth in that same hive.
All our hives are located on 42 acres and as of a month ago we hadn't encountered any diseases or insect infestations in any of our hives and they were all doing well and going strong.
This morning we are only left with questions...
1) Does this sound like CCD?
2) Can we combine the remaining bees in the "big hive" and the "split hive" in hopes they will be strong enough in numbers to pull through?
3) Are the boxes and equipment from these two hives contaminated or can they be salvaged somehow?
4) If we do combine the two hives should they be moved to a new location away from the two remaining hives that are still doing well (we hope)?
5) Can the honey from the "big hive" be taken home and slung? They have two supers full of honey but we don't know if we can eat the honey or not.
6) Is there anything we can do for the two hives that don't seem affected, other then just keeping an eye on them?
It's devastating to go out to your bees thinking you are going to be taking frames full of honey home to sling only to arrive to empty hives. Any input to what happened and what we can do moving forward is greatly appreciated.


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forum: Food & Drink
Pages: 1 | Home » Food & Drink » Flour
#1 Thu 29 Nov 12 4:36pm
- Member
- Member since Sat 14 Jan 12
If I can't get self-raising flour, (I live in the wilds in Spain), can I use normal flour with no problem?? Or would I have to add baking powder?? Want to make a jam roly poly this weekend!!
#2 Thu 29 Nov 12 7:18pm
- Member Occupation Chief cook and bottle-washer
- From Scotland
- Member since Mon 12 Sep 11
Re: Flour
You need to add baking powder. 3tsp per 225g according to my baking powder pot (that's the amount for "suet and steamed puddings".
Hope that helps!
#3 Fri 30 Nov 12 7:43am
- Forum super champ
- From Melbourne Australia
- Member since Sun 12 Apr 09
Re: Flour
The way it is done here is 2 tsp baking powder for every cup of plain flour to make self raising flour (cup is 250ml). Shake the baking powder well before opening so it mixes properly (it contains two different powders that start working when they get wet), and sieve the flour 2 or 3 times once you have added the baking powder so that it mixes through evenly.
Good luck with your roly poly!
#4 Fri 30 Nov 12 8:48am
- Forum champ
- From Estonia
- Member since Tue 06 Oct 09
Re: Flour
Self-Rising Flour Substitute
"1 cup (130 grams) (240 ml) similar grade (all purpose) flour plus 1 1/2 teaspoons baking powder plus 1/4 teaspoon salt"
They also list substitutes for different types of flours as well.
#5 Fri 30 Nov 12 9:09am
- Member Occupation Chief cook and bottle-washer
- From Scotland
- Member since Mon 12 Sep 11
Re: Flour
Yes - to clarify, the quantities I gave there were not to reproduce standard SR flour, they were the ideal quantities for steamed/suet puddings, according to my baking powder pot. It gives different quantities for different types of recipe, so in theory it should give a better result than SR flour. This is not according to my experience, however, I'm just reading it off the pot.
Pages: 1 | Home » Food & Drink » Flour


text:
EXAMPLE: Assessment of Migratory Students
Many migrant children home-based in Texas do not receive a high school diploma because their mobility at the beginning and end of the school year prevents them from taking and passing the Texas Assessment of Academic Skills (TAAS). (Passing the TAAS test is required for high school graduation in Texas.) Texas has arranged to have the TAAS administered to migratory students in several other States using local school personnel trained by Texas in the administration of the TAAS. Some States currently participating in this arrangement with Texas are Arkansas, Delaware, Illinois, Iowa, Missouri, Montana, Nebraska, North Dakota, and Washington.
[Return to Assessments]
Last Modified: 10/10/2003


text:
So my first craft show was yesterday. We got up bright and early. Well, it was early anyway - the sun is not out anymore in the morning. Don't you hate that this time of the year? I like it to be shiny & happy when I get up. *sigh* I digress...
We had everything packed up and ready to go the night before so all I had to do was get up, get cleaned, dressed and in the car. Made it to the show only 15 minutes after our assigned time. (Not bad! Me and early mornings do not mix.) Set up in about an hour (also not bad considering I tweaked my booth design a little bit last minute, and also had no idea if we'd be able to actually hang my banner as we'd not seen the booth spot to see if it'd be possible. But it was! And we did!). And we were ready to go and open for business on time!
Isn't it cute! (Don't get me started on how I realized, after the show was over, looking at the pictures, that the tablecloths aren't even...geesh!) But overall - cute, right?? :)
|My most wonderful, supportive, awesome helper for the day in the background there. <3
I loved getting the feedback from customers. A LOT of people LOVED the owls. Almost every single person who stopped, picked up the red guy on the end or the blue guy next to the tree. I heard the words "sooo cute!" and "very different" quite frequently. I got very good feedback on my products and booth in general.
Alas, and I know a lot of crafters have encountered this problem, I don't think this was the venue for me. I feel like the crowd was looking for deals. Or were used to seeing all the other cutsie items that were in the show that had a purpose. Plush don't have a purpose. (Do they need to? I guess with our economy the way it is - trying to be a plush maker right now might not be the best idea...) A lot of people wondered if they were doorstops. I had to say many times - "Nope. They're just for fun and for loving. If you can get them to hold your door for you too then I guess that's a little bonus!"
And when people asked the prices (I only had one sign with all the pricing on it...) I feel almost all of them were sticker-shocked. :( Ugh. Stupid big-box, mass-produced, commercial, made-in-China culture we live in! I curse you!!!! Not really. But it is a bummer. And a huge hindrance to those of us trying to do what we love and who put so much time into these things... (Crafters! Stop under-selling your work!!! It just adds to the problem!!) *sigh*
But again, overall, it was a good time. I ended up really enjoying myself. I loved talking to the customers and getting real, live feedback. So many people loved my stuff - it felt really good. :) I didn't do badly either. I mean, I didn't do great - but I did make my booth fees back plus some. So it wasn't bad for a first show.
Couple of shots of "my view" during the show:
So in summary - nothing fell over, got broken, stolen, I didn't get sick ;) , I made some decent sales, got great feedback, learned a lot and had fun. :)
But on a personal level, I'm glad it's over because now I feel like I can finally take a breather and actually get into the holiday season. Lately, I've been so rushed and busy, I haven't had any time for personal "for fun" crafting or felt that "warm fuzzy" that I love so much about this time of year.
And on a business level - I'm now going to be working on getting alllll my plush inventory (as well as some Christmas gift tags and some brooches) into the shop! (If you see anything in the pictures you like - call dibs now! Email me or leave a message in the comments and I'll contact you back with if it's still available as well as pricing, shipping, etc.)
I also decided that I'm going to be having a little giveaway for my blog readers to show my appreciation for your patience with me during these last couple weeks. <3 So stay tuned for that!


text:
Phone: 503-823-7740
Fax: 503-823-6995
1120 SW 5th Avenue, Room 1000, Portland, OR 97204
Phone: 503-823-7740
Fax: 503-823-6995
1120 SW 5th Avenue, Room 1000, Portland, OR 97204
Community members have asked how they can participate in the care and maintenance of Portland's green streets. Environmental Services has responded with the Green Street Steward program. If you live, work or run a business in Portland you qualify to be a part of this program.
The city takes care of green streets and welcomes your help. As a Green Street Steward you can help with simple activities that include picking up trash, removing leaves and debris, and occasional weeding and watering.
Participating in the Green Street Steward program is a rewarding way to contribute to your community and keep Portland's rivers clean. Read more about the program and find out how you can become a Green Street Steward.
When you sign up to become a Green Street Steward, you will be directed through a series of steps including:
Call 503-823-8764 or email firstname.lastname@example.com.
Green street facts
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text:
house of 1000 corpses was good movie too imo
house of 1000 corpses was good movie too imo
Moke is breaking my heart right now.
Mood: WOOF!
Pet Cemetery scared me. But the most traumatic show to me was Alfred Hitch****'s An Unlocked Window. I was a kid when I saw it and have never recovered. My parents should have never let me watch that show. It was on tv.
A little known classic horror movie is Bob Clark's 1974 "Black Christmas". This is the same director who made the Christmas comedy classic, "A Christmas Story".
This is credited as being the first true slasher movie, except it relies on creepy environment/cinematography to achieve its scares rather than blood/gore.
Basic plot: A killer is terrorizing a sorority house during Christmas break. It is truly quite a disturbing film, and if you watch it by yourself at night I guarantee you will be creeped the **** out.
If you have not seen this film and are a fan of horror movies you NEED to see this.
Here is one of the creepiest scenes
Easily the creepiest horror movie I have ever seen next to John Carpenter's original Halloween. You can tell Carpenter was inspired by this film.
Let's put the women and children to bed and go lookin' for dinner
Have any of you seen A Serbian Film? It literally rapes your soul. I actually don't recommend it to anyone lmao it's that psychologically disturbing.
Mood: WOOF!


text:
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Online registration entitles you to get your product warranty extended for free and to access to other online exclusive advantages (such as Battery for Life and others).
Product registration is voluntary; failure to register does not affect your statutory rights.
Worx respects your privacy Please see our Privacy Statement for more details
If you want to register a Worx DIY or Worx Garden tool, click here


text:
Winter Light: Selections from the Collection of Thomas Clark
January 25, 2014 - May 11, 2014
A selection of approximately twenty winter landscape paintings from the collection of Thomas Clark will be featured. In the early twentieth century, winter scenes emerged as a major genre for American landscape painters. Major practitioners of the winter landscape aesthetic will include Aldro Thompson Hibbard, Hobart Nichols, Ernest Lawson, Arthur James Emery Powell, Arthur Clifton Goodwin, and Walter Koeniger.


text: I am taking my family to our first Giants game and wanted some advice. Since we are bringing kids, we have decided to purchase club seats. We are thinking about the coaches club, but wanted to make sure these are worth the money? Also, any tips/suggestions would also be appreciated.


text:
This page contains The Avengers trailer - New York Comic Con - Chris Evans. Also don't forgot to watch other "The Avengers trailers" which you can find at this page. If current version of the trailer don'y work try to watch any other version of this trailer in right side list!
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Elluminate provides a Configuration Room that can be used only to test your connection, settings, and configure your audio at any time. Some schools have issues with firewalls and proxy servers. Detailed information can be found on the Elluminate Knowledge Base and FAQ's site.
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text:
Hello all,
My name is Joe and I found this site after buying a Boba helmet off Ebay.
I have been a prop colector for around 4 to 5 years and collect mostly Vader and Predator stuff. I have multiple Vader helmets along with a full size ESB/ROTJ Vader costume/display. I also have quite a few predator masks and a display bust.
Any way, I bought this Boba Fett helmet off Ebay and I figured it would be a good project for me. The seller stated it was a Mystery helmet, but I think it may be a MSH2, judging by some of the threads on this forum.
Maybe the Mystery and the MSH2 are the same?
Here are pics of it that I took after I repaired some cracks that were in it when it arrived.
The cracks were running up and down from the corners of the T-Visor cut out, on both sides. :cry They were close to going all the way through, so with a little pressure you could actually bend the sides out quite a bit.
If you look at the pics of the inside of the helmet you can see darker areas where I added a few layers of fiberglass cloth to sturdy up where the cracks were.
This worked very well and I think I am ready to start cleaning up the T-visor cut and cut out the holes in the back.
Any suggestions and info on what type of helmet this is would be greatly appreciated.
Thank you,


text:
Modify/Customise existing WordPress Plugin -- 2
This project is now closed with a project budget of $10 - $30 USD.Get free quotes for a project like this
Project Budget$10 - $30 USD
Project Description
I have purchased the WordPress plugin Affiliate Egg and i require customisation to the existing plugin. The plugin zip has been attached.
If you have no idea what is the affiliate egg plugin about please look at the youtube link for more information:[url removed, login to view]
Basically this Affiliate Egg plugin already supports several affiliate stores out of the box such as [url removed, login to view] and www.groupon.com.
The modification that i require is to create a "Custom parsers" to support the affiliate store groupon.sg.
There are instructions in the Affiliate Egg's plugin manual on how to create "Custom parsers" to support new affiliate stores. Please see page 14 and 15 of the PDF Manual. Link: [url removed, login to view]
You need to have php and xpath skills for this custom job.
For this customisation, i will need for "Custom parsers" to be created for the affiliate store groupon.sg.
- So, after the WordPress installation, go to menu > Affiliate Egg > Add Store front.
- I will be able to add (1) URL of single product page from [url removed, login to view] (2) Or Page with list of products/ Main Category Page.
Once you have completed the customisation, you are required to show me the screenshot that it works and send me the codes to test.
You will not be given test WordPress website accounts. You will need to setup this plugin in your own test website environment.
Please let me know if there is anything that you are unclear of. Or need additional clarifications.
Let me know if you can take up this job. And when can you complete this job by?
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