text:
Easily access more than 100,000 products and tools with our robust search engine. Manage your entire IT lifecycle from purchase to renewal all in one place — so you can get more done faster.Sponsored Listing
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Linux Knowledge Base and Tutorial
The Linux Knowledge Base and Tutorial (LINKBAT) is a web-based, unified knowledge base and tutorial with the goal of educating users about Linux.46 weekly downloads
Pre-defined Compiler Macros
Overview of pre-defined compiler macros for standards, compilers, operating systems, and hardware architectures.8 weekly downloads
richt, tight and beautiful GUI text editor made in Perl, WxWidgets & Scintilla. Releases: WIN(stable|testing), GTK&Mac (please use CPAN installer) other packages in planning2 weekly downloads
With Qlik Sense Cloud Business, you get all the power of Qlik's unique associative engine and all the convenience of a cloud-based solution – so your team can share insights with confidence and ease. Curious to see how it works? Watch the webinar now.Are you an IT Pro at a company with between 1-500 employees?Sponsored Listing
Java Slideshow
Java Slideshow is a platform independent image viewer especially for huge collections. It provides an easy command line interface, supports tagging and view by category, zoom, move and has some file manager functions like delete file or find duplicates.3 weekly downloads
UPC Database
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Low Power Solar/WindPower Capable -Fast FRee ATSC/DVB-T DVR Backend4 weekly downloads
Mailman Module for Webmin
This is project maintains the Mailman module for the Webmin administration tool. Network admins can easily control their mailing lists through the Webmin interface.2 weekly downloads
A small, fast, secure, anti-spam SMTP mail server (MTA). Delivery to mbox files and Maildirs supported. qwik-smtpd supports RBL, relay checking, raw/custom message handlers, and more. Custom authentication via checkpassword and a qmail-compatible configu3 weekly downloads
You've likely added a tool to fix one problem and then a different tool to fix another problem. Pretty soon you have multiple instances of the same tool, different tools with overlapping functionality, no ability to collaborate across teams—all resulting in unknown bottlenecks and complicated or no reporting. As a DevOps leader, it's up to you to balance the autonomy and flexibility of a DevOps approach. But how?Sponsored Listing
XR-Kore... XR-Kore is FREE, OPENSOURCE, Based on OPENKORE, Perl based Custom Ragnarok Online Client Bot...3 weekly downloads
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GEDCOM Import/Export-Filter
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Join ACM and take advantage of thousands of online courses, video tutorials, and online books available through ACM's online Learning Center. Stay ahead of the curve by reading Communications of the ACM, our monthly flagship publication that delivers incisive essays, reviews and research, and ACM Queue, an online magazine for software developers written by leading software engineers, computing researchers and tech entrepreneurs.Sponsored Listing
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We are an expert business telecommunications consulting and technical services company, serving clients all over Canada. We provide our clients with useful information and advice they need to make sound decisions to meet their business technology goals. Whether it's managing client's existing communication and collaboration solutions or creating a new state of the art technology solution, our certified technicians and engineers are dedicated to providing with exceptional service. We design, program, install and provide technical services and support for the latest voice, video, data, unified communications technologies and related infrastructure.
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subset: commoncrawl


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Today's Devotional
Reflections of MarriageWhat's the Holy Spirit's role in a marriage between two believers?
Top Music Videos
joanna678's FavoritesBack to joanna678's channel.
- Prophecy Update: Signs in the Heavens. A MUST SEEThe Eclipses are on the Jewish Feasts in the year 2014-15 minus 7 years is this summer...Steve Hadley of Harvest Family Fellowship Reno Nevada gives Prophecy Update on how we are so very close to end of this age, the Rapture of the Church and the ...kendonna12010-10-01T22:43:2175,232 views00:29:37
- The Mazzeroth, The Gospel in the Stars.Is there a message hidden behind the Signs of the Zodiac? Are there secrets hidden in the original names of the constellations? What we know as the Signs of the Zodiac is known in Hebrew as the Mazzeroth. Before the occultic traditions and teachin...kendonna12010-10-01T23:01:4013,022 views00:13:21
- Shawn McDonald - Closer (Slideshow With Lyrics)Brand new single Closer from Shawn McDonald.shawn-mcdonald2010-11-09T17:35:0416,307 views00:03:27
- skillet skillet awake and aliveactressgirl2011-03-14T19:51:261,980 views00:03:33


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NEIGHBORHOOD YARD SALE - garage & moving sales - yard estate sale
....will be having a Memorial Weekend neighborhood yard sale. Several homes in the area will have quality.... → Read More
YardSales.net is the fastest growing yard sale site, with 0 sale photos and 14 garage sales in Ravenna, Kentucky. YardSales.net offers you the best list of Ravenna yard sales every week.


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Lovelies that make you want to stay a while.
Your coupon will be applied to the highest regular-price, eligible item in your cart.
Offer good for one item at regular price only. Limit one coupon per customer per day. Must present coupon at time of purchase. Offer is not valid with any other coupon, discount or previous purchase. One cut or one bolt of fabric or trim "by the yard" equals one item. Online fabric & trim discount is limited to 10 yards, single cut. Excludes Heidi Swapp™ Minc.™ Foil Applicator, CRICUT® products, Gemini Machine™ Crafters Companion, Silhouette CAMEO® Machine, candy & snack products, gum & mints, helium tanks, gift cards, custom orders, special orders, labor, rentals or class fees. Cash Value 1/10¢.
Lovelies that make you want to stay a while.
Happy up your home and life.
For the days when you just gotta stitch.
A day spent papercrafting is a day well spent.
Plant some happy wherever you are.
Sweets and treats that make every day a party.
Turn blank canvases into masterpieces.
It's raining skeins.
Fun finds for making the most of sunny days.
Beads and more for statement pieces galore.
Your accessories should be as cool as you are.
Peace Sign Coloring Card with Envelope will make a wonderful and beneficial gift. Perfect for de-stressing and self-expressing. Coloring stimulates the right brain, fosters clearer thinking, and is a fun activity to complete with family and friends.
Personalize it by coloring with pens or pencils, or send it as a blank gift to give the recipient a fun, creative project to complete.
Package contains 1 blank card and 1 envelope.
I love it! Add to wish list


text:
Tutustu kiinnostaviin ideoihin!
In her series "Natural Act", Turkish photographer Merve Özaslan makes imaginative collages mixing vintage black and white photographs with colorful landscapes and natural elements
Wiley Coyote Clip Art | Funny Meme Breakfast Jobspapa
''Que a gente não precise das despedidas para lembrar o quanto gostamos de quem está perto. Que a gente não precise da saudade pra lembrar o quanto gostamos de quem está longe.'' [Marcos Lopes]
Inspired – Jesse Treece | purple woods
Jesse Treece
Maiko by Jesse Treece
Jesse Treece
mountains/head poster
Collage - Francisca Pageo
New Lands by Monster Rally / Ted Feighan
Villejavat / collage art
I came across these retro collages and was very drawn to the humor in them, along with the vintage imagery, color combo and pertinent social commentary all by Belgium artist Sammy Slabbinck.
Hulda Guzman, Fiesta en el Batey, 2012
Collage – Jesse Treece


text:
Unformatted text preview: PSY 1101L
Tuesdays 8:3010:00 & Fridays 10:0011:30
Morisset 218 Video #1
Video #1 Origins of Psychology
=65dyBoqGSgU The Beginnings of Psychology
The Beginnings of Psychology Subdiscipline of philosophy or biology Psychological Science Systematic Observations
Critical Thinking The Beginnings of Psychology
The Beginnings of Psychology Wilhelm Wundt University of Leipzig, Germany, December 1879
Reaction Time Experiments Structuralism
Structuralism The structural elements of the mind E.B. Titchener Introspection Functionalism Functionalism Focuses on the functions of our thoughts, feelings and ideas
Evolution through Natural Selection
William James Behaviorism
Behaviorism John Watson
Psychology must focus on observable behavior
Classical and Operant Conditioning Psychoanalysis
Psychoanalysis Sigmund Freud The Unconscious Mind Psychoanalysis Humanistic Psychology
Humanistic Psychology Abraham Maslow & Carl Rogers
Emphasized current environmental influences on our growth potential
Highlighted need for love and acceptance Cognitive Psychology & Cognitive Psychology & Neuroscience Cognitive Psychology Neuroscience Focus on how we encode, process, store and retrieve information
Sensation, perception, memory, problem solving study of the brain from a biological (what's it made of) and physiological (how it works) point of view Cognitive Neuroscience Video#2
Video#2 Current Perspectives in Psychology http://www.youtube.com/watch?v=
=1&list=PL9145FCAFEF1F13C4 Levels Of Analysis
Levels Of Analysis Biopsychosocial Approach
Biopsychosocial Approach ...
View Full Document
This note was uploaded on 03/02/2012 for the course PSY 1101 taught by Professor Textbook during the Winter '08 term at University of Ottawa.
- Winter '08
- Psychology, Experimental Psychology
Click to edit the document details


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India Summer
Picture Gallery
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Disclaimer: CoCoGals.com has a zero-tolerance policy against illegal pornography. We do not own, produce or host a pictures and videos displayed on this website. All videos are hosted by 3rd party websites. We have no control over the content of these websites.
Copyright © 2017 Coco Gals. All rights reserved.18 U.S.C.2257


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Great Idea for Stone Art
I'm going to paint stones like these. Cute!
Hand painted rock stone / sheep / beach stone / gift / Stone art / Painting / acrylic / home decor / decorative rock on Etsy, $15.24
diy Well it's not in english but it looks like a cool idea to do with a bunch of ladies having drinks or an easier version with kids ... Either way it's a nice idea to take a break..
Art on stones


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I started to loss my hair when I was 17. I was using minoxidil for at least 5 years but it stopped working for me. Now I am 25 and I was noticing...
I've recently come across some people who have had hair transplant work done in the Carribean. They say, and my initial research confirms, that you...
Hi everyone, I;m here for my husband who is just beginning his hair transplant story with Nuhart. My husband started losing his hair at 21 and didn't...
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I read up on hair loss...
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Hey guys, 25 yr old male, still have a good amount of hair but its def thinning. I can see alot my scalp when i get out of the shower, but when its...
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hello, guys I am new to this forum. This is my very first posting.
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Feel kind of daft doing this but at the same time Im glad there is somewere that I can find direction of were to go about my hair loss.
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text: Permian Basin Royalty Trust Company Profile (NYSE:PBT) Company Profile Analyst Ratings Earnings History Earnings Estimates Dividend History Insider Trade Headlines Social Media Chart About Permian Basin Royalty Trust (NYSE:PBT) Permian Basin Royalty Trust is an express trust. The Company's Waddell Ranch Properties has mineral interests in the Waddell Ranch. Its Waddell Ranch properties have proved reserves in six fields: Dune, Sand Hills (Judkins), Sand Hills (McKnight), Sand Hills (Tubb), University-Waddell (Devonian) and Waddell. As of December 31, 2016, the Waddell Ranch properties contained 794 gross (349 net) productive oil wells, 151 gross (64 net) productive gas wells and 250 gross (102 net) injection wells. Burlington Resources Oil & Gas Company LP operates its Waddell Ranch properties. In the six fields, there are 12 producing zones ranging in depth from 2,800 to 10,600 feet. Most prolific of these zones are the Grayburg and San Andres, which produce from depths between 2,800 and 3,400 feet. Also productive from the San Andres are the Sand Hills (Judkins) gas field and the Sand Hills (McKnight) oil field, the Dune (Grayburg/San Andres) oil field, and the Waddell (Grayburg/San Andres) oil field. Industry, Sector and Symbol: Sector: Oils/Energy Industry: Independent Oil & Gas Sub-Industry: N/A Symbol: NYSE:PBT CUSIP: N/A Web: www.pbt-permian.com Capitalization:Market Cap: $456.29 millionOutstanding Shares: 46,608,000Average Prices:50 Day Moving Avg: $9.80200 Day Moving Avg: $8.7652 Week Range: $6.10 - $10.30 P/E:Trailing P/E Ratio: 17.39P/E Growth: 0.00Sales & Book Value:Annual Revenue: $27.87 millionPrice / Sales: 16.37Book Value: $0.01 per sharePrice / Book: 979.00Dividend:Annual Dividend: $0.58Dividend Yield: 6.3% Profitability:Net Margins: 89.31%Return on Equity: 2,282.58%Return on Assets: 608.69%Debt:Current Ratio: 1.00%Quick Ratio: 1.00%Misc:Average Volume: 118,841 shs.Beta: 0.79Short Ratio: 1.92 Frequently Asked Questions for Permian Basin Royalty Trust (NYSE:PBT) What is Permian Basin Royalty Trust's stock symbol? Permian Basin Royalty Trust trades on the New York Stock Exchange (NYSE) under the ticker symbol "PBT." How often does Permian Basin Royalty Trust pay dividends? What is the dividend yield for Permian Basin Royalty Trust? Permian Basin Royalty Trust announced a monthly dividend on Friday, May 19th. Shareholders of record on Wednesday, May 31st will be paid a dividend of $0.0522 per share on Wednesday, June 14th. This represents a $0.63 dividend on an annualized basis and a yield of 6.39%. The ex-dividend date of this dividend is Friday, May 26th. View Permian Basin Royalty Trust's Dividend History. Who are some of Permian Basin Royalty Trust's key competitors? Some companies that are related to Permian Basin Royalty Trust include Resolute Energy Corp (REN), Energy XXI Gulf Coast (EXXI), Bonanza Creek Energy (BCEI), Delek Logistics Partners LP (DKL), Baytex Energy Corp (BTE), Denbury Resources (DNR), Eclipse Resources Corp (ECR), California Resources Corp (CRC), Sanchez Energy Corp (SN), Stone Energy (SGY), Abraxas Petroleum Corp. (AXAS), Earthstone Energy (ESTE), Approach Resources (AREX), Bellatrix Exploration Ltd (BXE), SandRidge Permian Trust (PER), Legacy Reserves LP (LGCY), Jones Energy (JONE) and LRR Energy LP (LRE). Who owns Permian Basin Royalty Trust stock? Permian Basin Royalty Trust's stock is owned by a number of of institutional and retail investors. Top institutional investors include POWELL LOYD (2.76%). View Institutional Ownership Trends for Permian Basin Royalty Trust. How do I buy Permian Basin Royalty Trust stock? Shares of Permian Basin Royalty Trust can be purchased through any online brokerage account. Popular online brokerages include Vanguard Brokerage Services, TD Ameritrade, E*TRADE, Scottrade, Fidelity and Charles Schwab. How much does a share of Permian Basin Royalty Trust stock cost? One share of Permian Basin Royalty Trust stock can currently be purchased for approximately $9.79. Analyst Ratings Consensus Ratings for Permian Basin Royalty Trust (NYSE:PBT) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: No ratings tracked in the last 12 months.Consensus Rating:N/A (Score: NaN)Consensus Price Target: N/A Analysts' Ratings History for Permian Basin Royalty Trust (NYSE:PBT) Show: Only the Most Recent Rating From Each Brokerage All Ratings For This Stock No equities research coverage for this company has been tracked by MarketBeat.com Earnings Earnings History for Permian Basin Royalty Trust (NYSE:PBT)No earnings announcements for this company have been tracked by MarketBeat.com Estimates Earnings Estimates for Permian Basin Royalty Trust (NYSE:PBT)No earnings estimates for this company have been tracked by MarketBeat.com Dividends Current Dividend Information for Permian Basin Royalty Trust (NYSE:PBT)Next Dividend:6/14/2017Annual Dividend:$0.58Dividend Yield:5.92%Dividend Growth:-24.60% (3 Year Average)Payout Ratio:181.26% (Trailing 12 Months of Earnings) Dividend History by Quarter for Permian Basin Royalty Trust (NYSE:PBT)AnnouncedPeriodAmountYieldEx-Dividend DateRecord DatePayable Date5/19/2017monthly$0.056.29%5/26/20175/31/20176/14/20174/18/2017monthly$0.066.68%4/26/20174/28/20175/12/20173/21/2017monthly$0.056.29%3/29/20173/31/20174/13/20172/17/2017monthly$0.1012.77%2/24/20172/28/20173/14/20171/20/2017monthly$0.056.94%1/27/20171/31/20172/14/201712/19/2016monthly$0.068.77%12/28/201612/30/20161/17/201711/18/2016monthly$0.057.74%11/28/201611/30/201612/14/201610/21/2016monthly$0.058.1%10/27/201610/31/201611/15/20169/20/2016monthly$0.057.67%9/28/20169/30/201610/17/20168/22/2016monthly$0.058.16%8/29/20168/31/20169/15/20167/20/2016monthly$0.046.85%7/27/20167/29/20168/12/20166/21/2016monthly$0.035.69%6/28/20166/30/20167/15/20165/23/2016monthly$0.036.13%5/26/20165/31/20166/14/20164/19/2016Monthly$0.011.87%4/27/20164/29/20165/13/20163/22/2016monthly$0.012.6%3/29/20163/31/20164/14/20162/22/2016monthly$0.024.69%2/25/20162/29/20163/14/20161/20/2016monthly$0.015.75%1/27/20161/29/20162/12/201612/21/2015monthly$0.024.85%12/29/201512/31/20151/15/201611/20/2015monthly$0.024.27%11/25/201511/30/201512/14/201510/21/2015monthly$0.023.45%10/28/201510/30/201511/16/20159/21/2015monthly$0.035.21%9/28/20159/30/201510/15/20158/24/2015monthly$0.047.02%8/27/20158/31/20159/15/20157/22/2015monthly$0.058.92%7/29/20157/31/20158/14/20156/22/2015monthly$0.045.37%6/26/20156/30/20157/14/20155/19/2015monthly$0.022.18%5/27/20155/29/20156/12/20154/21/2015monthly$0.023.14%4/28/20154/30/20155/14/20153/23/2015monthly$0.023.36%3/27/20153/31/20154/14/20152/18/2015monthly$0.033.67%2/25/20152/27/20153/13/20151/21/2015monthly$0.044.46%1/28/20151/30/20152/13/201512/22/2014monthly$0.055.85%12/29/201412/31/20141/15/201511/17/2014nov 14$0.054.58%11/25/201411/28/201412/12/201410/21/2014oct 14$0.065.45%10/29/201410/31/201411/17/20149/22/2014monthly$0.098.09%9/26/20149/30/201410/15/20148/19/2014aug 14$0.119.38%8/27/20148/29/20149/15/20147/21/2014jul 14$0.129.94%7/29/20147/31/20148/14/20146/20/2014jun 14$0.107.84%6/26/20146/30/20147/15/20145/20/2014monthly$0.1210.18%5/28/20145/30/20146/13/20144/17/2014apr 14$0.097.75%4/28/20144/30/20145/14/20143/21/2014mar 14$0.119.82%3/27/20143/31/20144/14/20142/19/2014monthly$0.098.22%2/26/20142/28/20143/14/20142/18/2014feb 14$0.092/28/20143/14/20141/22/2014monthly$0.054.62%1/29/20141/31/20142/14/20141/21/2014jan 14$0.051/31/20142/14/201412/23/2013monthly$0.076.16%12/27/201312/31/20131/15/201412/20/2013dec 13$0.0712/31/20131/15/201411/20/2013monthly$0.065.34%11/26/201311/29/201312/13/201311/18/2013nov 13$0.0611/29/201312/13/201310/22/2013monthly$0.107.35%10/29/201310/31/201311/15/201310/21/2013oct 13$0.1010/31/201311/15/20139/23/2013monthly$0.118.99%9/26/20139/30/201310/15/20139/20/2013sep 13$0.119/30/201310/15/20138/21/2013monthly$0.098.06%8/28/20138/30/20139/16/20138/20/2013aug 13$0.098/30/20139/16/20137/22/2013monthly$0.076.35%7/29/20137/31/20138/14/20137/19/2013jul 13$0.077/31/20138/14/20136/19/2013monthly$0.087.18%6/26/20136/28/20137/15/20136/18/2013jun 13$0.086/28/20137/15/20135/21/2013monthly$0.097.99%5/29/20135/31/20136/14/20135/20/2013may 13$0.095/31/20136/14/20134/19/2013monthly$0.065.93%4/26/20134/30/20135/14/20134/18/2013apr 13$0.064/30/20135/14/20133/19/2013monthly$0.065.64%3/26/20133/28/20134/12/20133/18/2013mar 13$0.063/28/20134/12/20132/19/2013monthly$0.043.16%2/26/20132/28/20133/14/20132/15/2013feb 13$0.042/26/20132/28/20133/14/20131/22/2013monthly$0.054.2%1/29/20131/31/20132/14/20131/18/2013jan 13$0.051/31/20132/14/201312/21/2012monthly$0.065.31%12/27/201212/31/20121/15/201312/20/2012dec 12$0.0612/31/20121/15/2013(Data available from 1/1/2013 forward) Insider Trades Insider Trading History for Permian Basin Royalty Trust (NYSE:PBT)No insider trades for this company have been tracked by MarketBeat.com Headlines Headline Trends for Permian Basin Royalty Trust (NYSE:PBT) Latest Headlines for Permian Basin Royalty Trust (NYSE:PBT) Source: All Sources Trusted Sources MarketBeat.com Bloomberg MarketWatch Motley Fool NASDAQ Reuters Seeking Alpha The Street The Wall Street Journal Yahoo Finance DateHeadlinePermian Basin Royalty Trust (PBT) to Issue $0.05 Dividendwww.americanbankingnews.com - May 21 at 12:54 PMPermian Basin Royalty Trust Announces May Cash Distributionfinance.yahoo.com - May 19 at 11:56 AMPermian Basin Royalty Trust (PBT) Receives Daily Coverage Optimism Score of 0.22www.americanbankingnews.com - May 4 at 9:50 AMPermian Basin Royalty Trust breached its 50 day moving average in a Bearish Manner : PBT-US : May 3, 2017finance.yahoo.com - May 3 at 7:54 PMFavorable News Coverage Likely to Affect Permian Basin Royalty Trust (PBT) Stock Pricewww.americanbankingnews.com - April 29 at 4:47 PMPermian Basin Royalty Trust (PBT) Receives News Sentiment Score of 0.47www.americanbankingnews.com - April 25 at 10:30 AMPermian Basin Royalty Trust (PBT) Earning Somewhat Positive Media Coverage, Analysis Showswww.americanbankingnews.com - April 21 at 9:54 PMPermian Basin Royalty Trust (PBT) Receiving Favorable News Coverage, Report Findswww.americanbankingnews.com - April 18 at 11:58 AMPermian Basin Royalty Trust declares $0.056259 dividendseekingalpha.com - April 18 at 10:02 AMPermian Basin Royalty Trust Announces April Cash Distribution And 2017 Reserve Quantitiesfinance.yahoo.com - April 18 at 9:53 AMSomewhat Favorable Press Coverage Very Likely to Effect Permian Basin Royalty Trust (PBT) Share Pricewww.americanbankingnews.com - April 15 at 1:21 PMPermian Basin Royalty Trust (PBT) Ex-Dividend Date Scheduled for March 29, 2017 - Nasdaqwww.nasdaq.com - March 30 at 5:54 AMPermian Basin Royalty Trust to Issue Monthly Dividend of $0.05 (pbt)www.americanbankingnews.com - March 24 at 11:27 AMPermian Basin Royalty Trust Announces March Cash Distributionfinance.yahoo.com - March 21 at 11:07 AMPermian Basin Royalty Trust: Small-Cap Alphaseekingalpha.com - March 20 at 5:14 PMPERMIAN BASIN ROYALTY TRUST Financialsfinance.yahoo.com - March 16 at 7:51 PMPERMIAN BASIN ROYALTY TRUST Files SEC form 10-K, Annual Reportbiz.yahoo.com - March 10 at 8:54 PMPERMIAN BASIN ROYALTY TRUST Files SEC form 8-K, Non-Reliance on Previous Financials, Audits or Interim Review, Financbiz.yahoo.com - March 3 at 7:09 PMPermian Basin Royalty Trust (PBT) Ex-Dividend Date Scheduled for February 24, 2017 - Nasdaqwww.nasdaq.com - February 24 at 12:13 AMEx-Div Reminder for Permian Basin Royalty Trustwww.nasdaq.com - February 22 at 7:15 PMPermian Basin Royalty Trust Announces February Cash Distribution - Yahoo Financefinance.yahoo.com - February 18 at 6:18 PMPermian Basin Royalty Trust Announces February Cash Distributionus.rd.yahoo.com - February 17 at 4:48 PM11:03 am Permian Basin Royalty Tr. declares February distribution of $0.101910/unit vs. $0.048012/unit in Januaryus.rd.yahoo.com - February 17 at 4:48 PMPermian Basin Royalty Trust About To Put More Money In Your Pocket (PBT)www.thestreet.com - January 25 at 11:30 PMPermian Basin Royalty Trust Announces January Cash Distribution - PR Newswire (press release)www.prnewswire.com - January 21 at 6:53 PMPermian Basin Royalty Trust Announces January Cash Distribution - Yahoo Financefinance.yahoo.com - January 21 at 12:58 AMPermian Basin Royalty Trust Announces January Cash Distributionus.rd.yahoo.com - January 20 at 7:58 PMPermian Basin Royalty Trust (PBT) Ex-Dividend Date Scheduled for December 28, 2016 - Nasdaqwww.nasdaq.com - December 28 at 9:49 AMPermian Basin Royalty Trust Announces December Cash Distributionus.rd.yahoo.com - December 20 at 6:34 PMPermian Basin Royalty Trust Announces December Cash Distribution - PR Newswire (press release)www.prnewswire.com - December 20 at 1:34 PMHottest Financial Stocks Now - PLBC PBT IBN IMH - Investorplace.cominvestorplace.com - December 2 at 6:47 PMPermian Basin Royalty Trust declares $0.047087 dividendseekingalpha.com - November 19 at 9:23 AMPERMIAN BASIN ROYALTY TRUST Files SEC form 8-K, Results of Operations and Financial Condition, Financial Statements abiz.yahoo.com - November 18 at 6:21 PMPermian Basin Royalty Trust (PBT) Declares $0.047121 Monthly Dividend; 7.9% Yieldwww.streetinsider.com - October 22 at 10:43 AMPermian Basin Royalty Trust declares $0.047121 dividendseekingalpha.com - October 22 at 10:43 AM Social Chart Permian Basin Royalty Trust (PBT) Chart for Sunday, May, 28, 2017 Table of Contents Company Profile Analyst Ratings Earnings History Earnings Estimates Dividend History Insider Trades Headlines Social Media Chart This page was last updated on 5/28/2017 by MarketBeat.com Staff


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Tom Seabron
|No. 53, 58
|Personal information
|Date of birth:
|May 24, 1957
|Place of birth:
|Baltimore, Maryland
|6 ft 3 in (1.91 m)
|215 lb (98 kg)
|Career information
|High school:
|Cass Technical High School, Detroit, Michigan
|NFL Draft:
|1979 / Round: 5 / Pick: 111
|Career history
|Player stats at PFR
Thomas Hall Seabron Jr. (born May 24, 1957) is a former American football player. He played college football for the University of Michigan from 1975 to 1978 and professional football in the National Football League (NFL) for the San Francisco 49ers (1979–1980) and St. Louis Cardinals (1980).
Early years[edit]
Seabron was born in Baltimore, Maryland, in 1957. He attended high school in Detroit, Michigan at Cass Technical High School.[1]
University of Michigan[edit]
Seabron played college football for the Michigan Wolverines football team from 1975 to 1978.[2] He played at the tight end and defensive end positions in 1975 and 1976 and at the outside linebacker position in 1977 and 1978.[2]
Professional football[edit]
Seabron was drafted by the San Francisco 49ers in the fifth round (111th overall selection) in the 1979 NFL Draft. He appeared in 16 games as a linebacker and on special teams for the 49ers in the 1979 and 1980 NFL seasons.[1] Seabron was released by the 49ers in October 1980 after appearing in six games.[3] He signed with the St. Louis Cardinals as a free agent in the first half of December 1980 and appeared in the final two games of the 1980 NFL season for the team.[1][4] Seabron was released by the Cardinals in August 1981.[5]
- ^ a b c "Tom Seabron". pro-football-reference.com.
- ^ a b "University of Michigan All-time Rosters Search Page". University of Michigan, Bentley Historical Library.(Enter Seabron as the last name on the search page, and press enter)
- ^ "Cut kicker breaks neck in accident". The Modesto Bee. October 18, 1980.
- ^ "Seabron signed". The Michigan Daily. December 10, 1980.
- ^ "Cards release 10 players". St. Joseph Gazette. August 5, 1981.


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text: Pinch to zoom Ocean Blue Foam Salad Bowl by Dibor £24$42.13€29.27$31.69 Favourite Favourite View your favourites quantity personalise & pay PRODUCT DETAILS ask seller a question save for later A fantastic focal point to any table... Beautiful, weighted, strong yet elegant glassware made in Italy. Each bowl boasts a unique bubble design in the mould and is tinted in the most alluring shade of ocean blue.A fantastic size to serve a generous helping of fresh seasonal produce. Just as perfect for a formal dinner party as it is for an alfresco garden party. made from: Glass dimensions: Diameter 24.5 x H1.5cm product code: 577431 DELIVERY This product is dispatched to you by Dibor. RETURNS You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Dibor's return policy Please see notonthehighstreet.com's returns policy.


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A working group of the European Society for the Study of Tourette Syndrome (ESSTS) has developed the first European assessment guidelines of Tourette Syndrome (TS). The available literature including national guidelines was thoroughly screened and extensively discussed in the expert group of ESSTS members. Detailed clinical assessment guidelines of tic disorders and their comorbidities in both children and adults are presented. Screening methods that might be helpful and necessary for specialists' differential diagnosis process are suggested in order to further analyse cognitive abilities, emotional functions and motor skills. Besides clinical interviews and physical examination, additional specific tools (questionnaires, checklists and neuropsychological tests) are recommended.
Tics are defined as sudden, rapid, recurrent, non-rhythmic motor movements or vocalizations usually appearing in bouts while waxing and waning in frequency, intensity and kind of tic [1]. Tic disorders including Gilles de la Tourette or Tourette Syndrome (TS) typically onset in childhood mostly at the age of 5 to 6 years [2, 3]. TS encompasses the combination of chronic (more than 1 year) motor and vocal tics. TS is often underdiagnosed and many patients do not receive adequate information and care [5, 6], and thus suffer from psychosocial impairment for a long time. On average, it takes more than 5 years from first onset of symptoms to diagnosis [7]. Patients and their families are frequently unable to correctly identify the symptoms and patients sometimes get stigmatised as a consequence of their tics. Therefore, they often experience a great relief to get a diagnosis because this allows them to better cope with the situation. There is no cure for TS, therefore, treatment aims to diminish tic severity and frequency. Often it is more important to manage the commonly comorbid conditions in order to improve psychosocial functioning and development. So far, to the best of our knowledge, only in Germany explicit guidelines for the diagnosis and treatment of TS exist (German Guidelines of child and adolescent psychiatry [8] and neurology [9]). In the past years, there has been an increasing interest in research on aetiology, pathophysiology, diagnosing and treatment of TS, leading to valuable new insights on many aspects of the syndrome. Therefore, experts of the European Society for the Study of Tourette Syndrome (ESSTS) have developed the first European guideline in four parts (this issue). This part deals with the assessment of tic disorders in children, adolescents and adults.
TS affects between 0.3 [10] and 1% [11] of the population, a.o. depending on age of the study group and rigorousness of the sampling method used. Tics occur predominantly in young people (before age 18), and tend to have a waxing and waning course [12]. Importantly, a TS diagnosis is twice more likely to occur in non-Hispanic white persons than in Black persons or in Hispanics [10]. There is a male to female preponderance of between 3:1 [10] and 4.3:1 [13, 14].
The mean age at onset is around 5 years although lower ages at onset are reported in up to 40% of persons. Waxing and waning is the rule. Complex tics generally appear later than simple ones and phonic tics appear later than motor tics [15], usually after 1 or 2 years, with <5% of patients developing phonic tics first [16]. For most patients, the worst ever period of tics occurs between 8–12 years of age [17, 18].
The course of tics is relatively favourable over time. Clinical as well as population-based studies indicate that up to 80% of persons who have presented with a tic disorder before age 10 experience a significant tic decrease during adolescence, and by age 18 tic intensity and frequency has decreased to such an extent that the person no longer experiences any impairment from tics, although objective ratings indicate that most persons still have mild tics [19]. Yet, a small proportion of patients (20%) does not experience a decrease in tic intensity, and in this group some individuals not only experience tic worsening in adulthood but develop the most severe and debilitating forms of tic disorders. Reports on whether certain types of tics in childhood predict tics or comorbidity in adulthood are somewhat conflicting [20–26]. Frequency and severity of tics in childhood is hardly predictive of tic severity in adulthood [22]. However, children and adolescents with tics experience worse quality of life than healthy children (but better than psychiatric controls) [27], and poorer quality of life is related to increased tic severity [28]. Poor quality of life in adults with TS is associated with persistence of OCD [29]. Comorbid OC symptoms in children with TS onset at a somewhat later age (around 10 years) than tics and, in children with tics, tend to remit in only about 40% of patients [29]. Further new onset of OCD at a later age might occur [12]. Interestingly, persistence of OC symptoms into adulthood is particularly related to high IQ, and to smaller caudate volume measures in children [23, 30].
ADHD symptoms in TS children occur in the majority of cases before tic onset, and in one third of children after tic onset [31]. ADHD symptoms tend to decrease in 20% of children during adolescence but later than tics. Interestingly, OC symptoms in childhood predict OC symptoms and more ADHD symptoms in adolescence and adulthood, and ADHD in childhood predicts more OCD in adulthood [17, 26]. Finally, persistence of ADHD into adulthood is related to poorer psychosocial functioning. In conclusion, the following picture emerges: as tics in childhood hardly predict long-term outcome, comorbid OCD and ADHD are associated with poorer psychosocial functioning.
Family studies of TS consistently show a 10- to 100-fold increase in the rates of tics and TS in first degree relatives of TS patients compared to control families, indicating a strong genetic component to be operant in the disease [31–33]. Tic severity increases with bi-lineal transmission [34]. Further, independently of whether the proband has concurrent OCD, first degree family members of TS patients have elevated rates of early-onset OCD, especially the female relatives, suggesting that—in TS—OCD is an alternate expression of the TS phenotype [32]. With respect to ADHD transmission, the picture is slightly different; although rates in first degree relatives of TS families are significantly elevated, ADHD is mostly comorbid with tics in the relatives, pointing into the direction of shared aetiology, i.e. associated but not comorbid in the strict sense [35], and not ADHD as an alternate expression of the disease [31]. In summary, these family studies strongly indicate a genetic component to be operant in TS, with shared genetic influences between tic and OCD, but it is unclear for ADHD. A large Genome Wide Association Study within the TSA genetic consortium is underway [36] (for a review on the genetics of TS: see O'Rourke et al. [37]).
MRI studies with different techniques [38–43] and electrophysiological investigations [44] on neuronal inhibition have identified alterations in brain areas of the cortico-striato-thalamo-cortical (CSTC) circuits. Finally, PET raclopride studies using amphetamine challenge to study D2 receptor availability in striatal circuits in TS patients have revealed increased phasic dopamine release in ventral striatal areas in TS patients after amphetamine challenge [45, 46] (Table 1).
Tics can either be diagnosed according to the tenth International Classification of Disease (ICD)-10 criteria or according to criteria of the Diagnostic and Statistical Manual Text Revision, fourth edition (DSM-IV-TR) [47]. These classification systems are fully compatible. According to DSM-IV-TR criteria, tic disorders are grouped under the disorders that first occur in infancy, childhood or adolescence, and encompass four categories, i.e. Tourette's disorder (307.23), chronic motor or vocal tic disorder (307.22), transient tic disorder (307.21) and tic disorder not otherwise specified (307.20) (Table 2). In ICD 10, the same categories exist and the differences are minimal. In DSM-IV-TR [4] one item has been omitted that is mentioned for nearly all mental disorders and has previously been necessary for the diagnosis of TS: "The disturbance causes marked distress or significant impairment in social, occupational or other important areas of functioning". This modification was made in recognition of the fact that clinicians see patients who meet all the other criteria for TS, but do not have distress or impairment.
For DSM-V (expected in 2013), only minor changes have been recommended, designed to clarify and simplify the diagnostic criteria, and reduce the use of the tic disorder not otherwise specified category. A European commentary on recent DSM-V version can be found in this Journal [48]. Specific recommendations include a.o: (1) simplification of the duration criterion for the tic disorders; any person who has tic symptoms of less than 12 month duration but more than 4 weeks duration receives the diagnosis 'provisional tic disorder'; (2) establishing new tic disorder categories for substance induced tic disorder and tic disorder due to a general medical condition; (3) including a motor tic only and vocal tic only specifier for the chronic motor or vocal tic disorder category [49].
To establish a diagnosis of TS, a person must have (1) the combination of two or more motor tics and one (or more) phonic tic, that have been present at some time during the illness although not necessarily concurrently; (2) tics occur many times daily nearly every day through a period of more than 1 year; (3) onset before 18 years of age; and (4) are not directly caused by a general medical condition or by substance use.
Motor tics are described as brief, sudden, irresistible, inapposite and non-rhythmic recurrent movements in voluntary muscles or muscle groups [50]. Most common tics occur in the face, neck or shoulder musculature and encompass a.o.: eye blinking, nose and mouth twitches and shoulder jerks.
Vocal tics are defined as sounds elicited by a flow of air through the vocal cords, mouth or nose and the most common vocal tics are: throat clearing, grunts, high-pitched sounds and sniffing. Amongst the most well-known vocal tics is coprolalia (i.e. the uttering of socially inappropriate words), which occurs only in between 14 and 20% of patients [51]. Tics can be suppressed or inhibited depending on the situation. The suppression, however, causes an uncomfortable sensation.
Three essential 'tic' features can be recognised that are closely interwoven, i.e.: (1) temporary tic suppression [16]; (2) inner tension that accompanies tic suppression; (3) the feeling of active involvement in performing a tic, especially in adults. Although patients cannot permanently suppress the tic they might experience the tic as a conscious, intentional and self-directed movement executed to relieve a premonitory urge [52]. This feeling of intentionality is rarely present in children between age 4 and 8 but increases with age, and by age 12 the majority of patients recognises a premonitory urge preceding and exacerbating a tic [15]. This subjective perception is an important distinguishing feature from other hyperkinetic movement disorders [52].
Tics usually start in the face and tend to extend caudally, with a remaining preference for head, neck, shoulders and arms. Tics tend to significantly decrease during sleep, although—in contrast with previous notions—they often do not disappear [53]. Up to 60% of TS children and adults complain about disturbed sleep [54]. Polysomnography and simultaneous video recording during sleep in TS patients has revealed both an increased number of regular movements and more tics in all sleep stages but especially during REM sleep [53, 55, 56]. Patients show decreased sleep efficiency and slow wave sleep percentage, increased sleep latency, more awakeness and awakenings and more sleep stage changes during sleep. Severity of TS is positively associated with number of awakenings and sleep stage changes and negatively with sleep efficiency. Comorbid ADHD, a condition in which increased motor activity during sleep is found as well, seems to significantly add to the sleep problems in TS [56–58].
The intensity of tics depends in most cases on environmental cues, such as exciting or stressful events, although the nature of these environmental mediators has hardly been investigated systematically yet. In apparent contrast to this, tics can exacerbate during relaxation, for example whilst watching television. Situations or activities that require focused attention from the patient often diminish tics, both in children and adults [59].
Tics can be classified according to: type, complexity, whether they are isolated or multiple, and according to location, number, frequency and duration [6]. They also vary in terms of intensity or 'forcefulness' [69].
Tics can be motor, vocal, sensory or cognitive [60].
Motor tics arise in the voluntary musculature and involve discrete muscles or muscle groups. Tics can be seen as fragments of normal motor movements that appear out of context [61]. The most frequent tic is eye blinking. [16].
Phonic (or vocal) tics can consist of any noise produced by movement of air through the nose, mouth or pharynx. Tongue clicking is, therefore, not classified as a phonic, but a motor tic. The term 'phonic' should be preferred over 'vocal', since not all sounds (f.i. sniffing) are produced by the vocal cords. Less than 5% of patients with tics have phonic tics alone without associated motor ones [62], but motor tics without phonic tics are very common.
Many adult patients (up to 90%), are aware of premonitory sensations preceding the tics, with a mean age of starting to become aware of 10 years, and depending on type of tic [15]. More automatic movements such as eye blinking are less often preceded by sensory urges. These sensations are experienced as unpleasant somatosensory sensations, either within the muscles of the upcoming tic or somewhere else in the body or the head (tiredness, itch, pressure, stabbing pain, abdominal discomfort, heat or cold) and sometimes difficult to articulate. They are often relieved by execution of the tic [52, 63]. Younger children are much less aware of premonitory urges; 37% of children between 8 and 19 years are able to report on premonitory urges, whereas 64% of these children were able to suppress their tics. Thus, tic awareness does not seem to be a prerequisite for the ability to suppress tics, and awareness seems to increase with age, and be closely associated with cognitive development [64]. Premonitory urges can be bound to small localised areas, with 'hot spots' in the shoulder girdle, hands, feet and front of the thighs. They can also be more generalised, and described as a sense of 'inner tension' [61].
These tics have been described in adolescents and adults with TS and seem to occur predominantly in this age group [65–67]. They have been first described by Shapiro et al. [16] and termed 'impulsions' to delineate them from the anxiety-driven 'obsessions' that occur in 'pure' OCD patients. Thus, cognitive tics are described as repetitive thoughts that are not anxiety-driven but occur as a response to the excessive urge to give in or act upon provocative auditory, visual, tactile or inner stimuli [67]. Although exact frequencies are not known, cognitive tics encompass: echophenomena in thought, mental play [68], aimless counting and repetitive thoughts with sexual or aggressive content that produce no fear.
Tics can be subdivided into simple and complex [62]. Simple tics are restricted to one muscle or a single muscle group. Examples of simple motor tics are: eye blinking, nose twitching, tongue protrusion, head jerks and shoulder shrugs, etc. Examples of simple phonic tic are grunting, throat clearing, coughing, sniffling and barking, etc.
Complex motor tics often have a repetitive and/or compulsive nature. Examples are: the repetitive touching of objects or people, making elaborate sequences of movements, repetitive obscene movements (copropraxia), mimicking others (echopraxia) or wounding oneself (self-injurious behaviour). Complex phonic tics occur when sounds are elaborate or have a semantic content, including for instance words or phrases, expressing obscenities (coprolalia), repeating others (echolalia) or repeating oneself (palilalia). In general, complex motor tics are aimless or in response to an excessive premonitory urge. However, when the tic sequences are complex and elaborate it can be difficult to distinguish them from compulsions as seen in 'pure' OCD, the latter being more cognitively driven, goal-directed and aimed at reduction of anxiety [15].
One can have one tic that always originates from the same anatomical location (isolated) or many tics at multiple locations. Migration of tics from one location to another over longer periods of time is typical in chronic tic disorders. The tics wax and wane in intensity and complexity.
Tics are generally brief. They can be categorised as clonic (less than 100 ms) or dystonic and tonic (more than 300 ms). Dystonic tics are less common and are characterised by a repetitively abnormal posture of a kind that one may see in dystonia (e.g torticollis). In tonic tics, there is a relatively long duration of the contraction (in e.g. back muscles) without exhibiting abnormal postures.
In children and in adults, it is paramount to assess degree of impairment due to tics or comorbid conditions, although as described here above, in DSM-IV-TR [4] and in future DSM-V [49], the distress item has been omitted that was obligatory to establish a tic diagnosis in previous classifications. Impairment entails that the disorder is time consuming, causes significant distress and interferes with major domains of daily life of both children and adults, such as school, work status and (social) relationships. Impairment can be reliably measured with various instruments, including the impairment item on the Yale Global Tic Severity Scale (YGTSS), which separately rates impairment due to motor or vocal tics, on 0–4 scales [69]. Alternatively, impairment can be assessed using a Global Assessment of Functioning, both in children (C-GAS) [70] and in adults according to axis five of DSM-IV TR (2002 [47]). The scale runs from 0–90, with 0 indicating complete dependence on care by others, and 90 being healthy and excellently functioning in all areas of development, school/work and psychosocial functioning. Further, in children as well as adults the Clinical Global Impression Scale (CGI-S [71]) can be rated by the clinician. The CGI-S assesses change in global daily functioning (between 0 = much deteriorated and, via 3 = no change, to 6 = very much improved). The CGI-S has shown good face validity and is extremely easy to use, although interrater reliability is somewhat low [72].
Recently, a Quality of Life scale has been developed specifically for tic disorder patients [73, 74]. This 27 item scale is based on the health-related quality of life scale (HR-QOL) [75] with response ranges between 0 and 4, and assesses quality of life in four domains: psychological problems, cognitive problems, physical/Activity of Daily Living problems and obsessive–compulsive themes. Internal consistency as well as test–retest reliability are excellent. TS patients report elevated scores, predominantly in the domains of psychological and cognitive problems [73].
In clinical series, the large majority of cases (79%) have comorbid psychopathology, with attention deficit/hyperactivity disorder (ADHD) predominantly of the inattentive or combined subtype, being the most frequent comorbid disorder in up to 60% of the cases in both children and adults [31], followed by Obsessive–Compulsive Disorders (OCD), merely in adolescents and adults, anger control problems, sleep disorder, learning disorders, mood disorders, anxiety disorders and conduct and oppositional defiant disorders (CD/ODD). Sex differences occur with respect to this comorbidity, with predominance of males over females for ADHD, CD/ODD, anger control problems and learning disorders, and a female preponderance for OCD and self-injurious behaviour. Other comorbidities include impulsive, self-injurious and aggressive behaviour, autism spectrum disorders and sleep disorders [76]. Especially in adults, comorbidity often forms the main reason to seek help.
Tics need to be differentiated from other hyperkinetic movement disorders and from psychogenic movement disorders (Table 3). The features that distinguish tics from other movement disorders—with the exception of akathisia and psychogenic movement disorders—are (1) the ability to suppress them for a while, and (2) the patient's experience of tics as a (partly) voluntary movement to relieve an inner tension or a premonitory focal sensory sensation [77]. These features can be used to help differentiate from other movement disorders which characteristically worsen with action and are not suppressible [78] (Fig. 1).
A general evaluation of both children and adults includes assessment of the most debilitating complaints and symptoms, assesses how the symptoms developed and inquires about potential stressors and triggers. Especially in children, a developmental history is obtained. In children and adolescents, family functioning is assessed including parental coping styles and parental conflict, social network and financial & housing situation. In adults, partner status, current work and financial/housing situation is assessed as well. Moreover, if available hetero-anamnesis on tic and disease status is obtained from a partner, spouse or confidential person in the vicinity of the adult patient.
In children, adolescents as well as adults, it is highly advisable to supplement clinical interviewing with screens that rate general psychopathology. In children and adolescents, these are parent and/or teacher-derived, in adolescents complemented with self-reports, and in adults self-reports are taken, when necessary complemented with hetero-anamnestic assessments of a partner, parent or other person in the neighbourhood of the patient.
Self-report scales are recommended to provide general information on psychopathology. In children and adolescents, the parent-derived Child Behaviour checklist (CBCL) or—in adolescents and adults—the Young Adolescent Self-report or Youth Self-report which is fully in line, is highly recommended [79–81]. The same holds true for the SDQ (Strengths and Difficulties Questionnaire [82]; see also internet at www.sdqinfo.com). These scales are well validated across the different age groups, providing the clinician with the opportunity to follow children across the lifespan essentially using the same scale.
A detailed medical history is conducted (including medication and drug consumption in pregnancy by the mother, birth history, early development and past medication use by the patient etc.), and a complete psychosocial and family history to detect psychiatric and/or neurological conditions in relatives.
Interviews to assess disorders of infancy, childhood and adolescence including tics are abundant in child psychiatric settings. Various interviews are (1) compatible with international diagnostic systems (DSM-IV and/or ICD-10), and (2) explore the whole range of childhood derived disorders [83]. These are: the Diagnostic Interview Schedule for Children (DISC) [84, 85], the Children's Interview for Psychiatric Syndromes (ChIPS) [86], the Schedule for Affective Disorders and Schizophrenia for School-Age Children (Kiddie-SADS-PL; http://www.wpic.pitt.edu/ksads/default.htm; [83, 87], the Diagnostic Interview for Children and Adolescents (DICA[88]; psychometrically weak), the Child and Adolescent Psychiatric Assessment (CAPA) [89], of which young adult and young children versions are available; and the Interview Schedule for Children and Adolescents (ISCA [90]). All interviews are administered by clinicians and include a child/adolescent version and a parent version. In general, children seem to be better informants in describing internalising disorders, and adults (parents, teachers) more reliably describe externalising disorders [83]. The ISCA and the CAPA also explore on DSM-IV axis II diagnoses. Inter-rater reliability appears to be good for the 6 instruments, with kappa's ranging from 0.5 to 1. Overall, the K-SADS-PL has the best test–retest reliability [91] and is mostly used across countries, but takes somewhat lengthy interviewing (between 1 and 3 h).
Notably, in adults, no structured interviews are available that include the full range of disorders of infancy, childhood and adolescence including tic disorders. The most used instruments to assess other comorbid disorders are the Structured Clinical Interview on DSM-IV axis I disorders including the TR form (SCID-I [47, 92]; between 1 and 2.5 h), and the Mini International Neuropsychiatric Interview (MINI), which is an abbreviated version of the SCID-I and takes between 30 min and 1 h to complete [93]. Both the SCID-I and the MINI require training.
Age of onset of first tics should be recorded, as well as tic history and course and age at worst tic severity. Further, inquiries are made about which tics (or comorbid conditions) are considered to be most debilitating, and about their physical consequences (including pain/injury of muscles and joints), about somatosensory phenomena accompanying the tics, tic suppressibility and about exacerbating or relieving factors accompanying the tics (e.g. stress sensitivity). Patients and parents are asked about any possible relationship between infections (throat, ear) and tic exacerbation, to determine whether streptococcal autoimmunity could be a factor (e.g. in relation to Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) [94]). Patients and family members are questioned about the circadian profile of tic activity (including during sleep), to clarify the psychosocial impact of tics on family functioning, learning and quality of life [74]. Finally, the family history should be pinpointed to specific questions about tics, obsessive compulsive and ADHD behaviours in first degree family members.
The clinical examination is accompanied by standardised assessment of tics, comorbid conditions (including ADHD, OCD, self-injurious and anger control behaviours, mood and anxiety, sleep and learning difficulties) and their severity.
A considerable difficulty in assessing and quantifying tics is caused by (1) the spontaneous variations of tics in an individual over time, (2) The large variability in impact of a given level of physical tic severity on an individual or their family and (3) the tendency of patients to suppress their tics, especially when in the office with the clinician. Therefore, it is advisable when assessing tics, to use multi informant data, and to combine direct observation (both at home and in the school/work environment), historical information and—if available—to collect video data, in the clinical setting, 'home alone' or both [95]. Additional videotape tic monitoring might enhance capturing the whole tic repertoire of the patient. Various video protocols have been developed and extensively described, usually advising between 5 and 15 min of videotape recording [95–97].
In general (see Table 5), the evaluation of tics and comorbid symptoms in children and adults is highly comparable, using similar self-report scales and clinician-derived interviews. The differences predominantly lie in the person of the informant. In children this is mostly a parent, in adults the information is obtained—if available—from partner or spouse. In choosing an instrument it is advisable to make a choice based on (1) compatibility of the instrument to international (DSM-IV-TR) criteria; (2) the quality of its psychometric properties and (3) whether it provides scales that are normed across age groups, preferably ranging between infancy and adulthood.
A helpful assessment tool to systematically assess several aspects of the clinical history is of tics is the Diagnostic Confidence Index [98]. The DCI provides a score between 0 and 100 which allows clinicians to measure the likelihood that a person meets criteria of TS. However, validity and reliability criteria are not very well developed.
The most widely used checklists on tic characteristics and severity that combine an observant component and historical information obtained from the patients, parents and or spouses include the YGTSS [69], the Shapiro Tourette SyndromeSeverity Scale (STSSS) [16] and the Hopkins motor and vocal tic scale [99] (for an overview: see Kompoliti and Goetz [100]). The YGTSS includes a clinician-administered inventory of 30 items including 18 categories of motor and vocal tics, self-injurious behaviour and anger control problems to which a severity rating scale has been added. These 10 YGTSS severity items measure the number, frequency, intensity, complexity and interference of motor and phonic tics, and a separate impairment rating on 0–4 scales for each item [69]. Children and adults can be followed using the severity ratings. The YGTSS has high internal consistency and stability [101], convergent validity with other scales and discriminant validity. Overall, the psychometric properties appear to be better than in other scales. Two disadvantages are that time needed to collect information is up to 20 min and the use of the scale needs some training [100].
The STSSS is developed for clinical trials, encompasses five items including the noticeability to others, and interference of daily life due to tics [102]. The STSS is short, easy to use and reliable with high internal consistency. A limitation is that it does not assess tic characteristics. The Hopkins motor and vocal tic scale focuses both on tics and their impairments, using visual analogue scales on which physicians and parents separately rank motor and vocal tics. Three scores are obtained: a total score, a parent (or partner)-derived score and a rater score. Interrater reliability to evaluate tic severity is equally well as seen in the YGTSS, STSSS and CGI [99].
Recommendations are given to assess the most prevalent comorbid conditions, i.e ADHD and OCD. For recommendations on other comorbidities, we refer to Table 4.
To establish the presence and severity of comorbid ADHD, both in children, adolescents and adults, several rating scales can be used to screen on presence of ADHD. However, these scales can only be used as an aid to help diagnosing using standard interviews. With respect to interviews used, assessments should contain key questions for parents (of both children and adults; [103]) on present as well as past performance (starting before age 7) with respect to inattention, impulsivity and hyperactivity. In children, various well validated instruments are used, a.o. the Kiddie-SADS, and the DICA (see here-above). In adults, the picture is less clear, and various interviews, mainly based on DSM-IV criteria of ADHD, have been developed across countries [104]. The particular challenge in assessment of adults lies in the gathering of reliable information on behaviour that has started before age 7 to establish an ADHD diagnosis. This can be extremely difficult, particularly if no informants (parents, older siblings or other family members) are available to provide information on childhood behaviour, and when current comorbid depressive or other psychiatric symptoms hamper reliable information provided by the patient.
ADHD rating scales that are mostly used in children are: the Swanson, Nolan and Pelham questionnaire, 4th edition (SNAP-IV) [105] and the Children's version of the Connors ADHD Rating Scale (CAARS) [106, 107]. The SNAP-IV encompasses a 30 item validated self-report questionnaire with ratings between 0 and 4 per item. Internal consistency, interrater reliability and validity are good. The CAARS (66 item or 30 item versions) has a children's and an adult version and encompasses several subscales with ratings between 0 and 4 per item which measure ADHD symptoms, impulsivity, inattention and hyperactivity domains, and (in the long version) ratings with respect to global psychological functioning and self-esteem. The CAARS has the advantages of being thoroughly validated across different age groups, and is suitable to be filled in by multiple informants. The CAARS displays good internal consistency, interrater reliability and validity [103] but has—in adults—the disadvantage of not inquiring retrospectively, although it inquires on whether symptoms have been present before age 7 and caused distress or impairment. An adult self-report rating scale that meets with the criterion of retrospective inquiry on symptoms is the Wender Utah Rating Scale (WURS) [108].
In conclusion, in children the diagnosis of ADHD is more easy to establish than in adults, where assessments with multiple informants should be combined to establish a diagnosis of ADHD [103].
Some instruments designed to capture the OCD are suitable as a screener in epidemiological samples, some capture the OCD symptoms in clinical samples and some measure OC severity over time. Reliable screeners are: the OC symptom subscale of the CBCL [109] (as an adult version the OC scale of the YASR [110]), an 8 item screener on OC behaviour, and the SOCS [111], a 7 item screener on presence of OC symptoms, the latter being developed for adolescents between 11 and 18 years. Both screeners have good sensitivity and specificity in general populations of children but specificity is lower in psychiatric populations.
To assess symptoms and severity in clinical samples of children and adults, the Leyton Obsessive Inventory including both adult and children's versions are in use (LOI and LOI-CV; 20 and 11 item versions; yes/no answers and 0–3 answers, respectively) [112–114]. The LOI-CV has a self-report and a parent-derived form, the latter being preferable with respect to sensitivity to pick up OC complaints [115]. Disadvantages are that not all OC symptom domains are captured and that the scores predominantly correspond with compulsion severity and not obsession severity. Further, the Children's Obsessive Compulsive Inventory (CHOCI) has been developed [116], based on Maudsley Obsessive Compulsive Inventory [117] and with severity ratings comparable to the YBOCS severity scale [118]. The CHOCI has 14 symptom items and 6 severity items, and is useful as a severity rater but does not encompass the whole range of OC symptoms.
The most recommendable instruments to use which capture the full range of OC symptoms and assess OC severity in children as well as adults are the Children's Yale-Brown Obsessive–Compulsive Scale; CY-BOCS (in children)/YBOCS (in adults), entailing 58–80 items on symptoms and 10 severity items [118–120]), and the Obsessive–Compulsive Inventory-Child's Version; OCI-CV [121] and the adult version: OCI-R [122, 123]. The YBOCS symptom checklist + severity scale have interviewer-based as well as self-report based versions that are equally well in terms of sensitivity and specificity [124], and in children parent-derived versions are used. The (C)Y-BOCS extensively rates presence or absence of lifetime OC symptoms in four domains, of obsessions and checking, washing and contamination, symmetry/ordering behaviour and hoarding [125, 126]. Further, a 10 item severity rating is added, measuring obsession and compulsion severity separately with respect to: time consumingness, distress, interference, resistance and amount of control over obsessions and compulsions. As an extension, the Dimensional Y-BOCS (DY-BOCS) has been developed, in which symptom severity is measured separately over each symptom domain and avoidance ratings are added [127]. The YBOCS and DYBOCS scales have good psychometric qualities but are very time consuming; (between 1 and 3 h to assess symptoms). Therefore, as a much shorter alternative, the 18 item Obsessive Compulsive Inventory-revised version (OCI-R) [123] and as a child version, 21 item the OCI-R CV [121] is recommended. The OCI-R/OCI-CV encompass 18–21 items on OC symptoms in six symptom domains including doubting/checking, washing, ordering, hoarding and neutralising, with ratings between 0 and 4. Test–retest reliability, comparability with YBOCS and construct and divergent validity (i.e. higher correlations are found with measures of anxiety than depression) are all well.
A general physical and a specialised neurological examination is mandatory to ensure correct diagnosis and exclude severe or progressive neurological disorders [128]. The necessity for any further investigation is determined at this early diagnostic stage. In practice, the typical features of TS virtually rule out alternative major diagnoses. Atypical features such as apparent adult onset or severe deterioration or progression in symptoms should always lead to detailed consideration and investigation to include EEG and neuro-imaging.
Neurological examination is performed to distinguish tics from other movement disorders, most importantly myoclonic dystonias, some forms of epilepsia and stereotypies. In practice, myoclonus—brief shock-like movements of 'non-functional' muscle groups which are not suppressible and usually do not have an associated urge—are the most difficult movements to distinguish from tics. With the presence of sustained or dynamic abnormal postures, it is useful to enquire about and examine for signs of dystonia. A good technique to identify kinesogenic involuntary movements is to for instance observe the writing of the patients; an individual with a myclonic dystonia will need to steady the pen-holding hand with the other to avoid shock-like movements affecting the manoeuvre. Also, observation of fine motor tasks such as putting the lid on a pen is useful to exacerbate/test for myoclonus. Whilst 'dystonic tics' are well recognised, focal or generalised dystonias should not be mistaken for a tic disorder.
Additional investigation with the aid of MRI scanning or EEG is rarely indicated except in those cases where the presentation is not typical in terms of either the semiology of the movement disorder or the presence of features suggestive of the differential diagnoses mentioned above. Indeed, the more common situation is over-investigation, for instance with EEG in cases where a typical tic disorder is mistaken for epilepsy or myoclonus. It is worthwhile seeking expert opinion if doubt exists about the extent of investigation to pursue. Certain neurological conditions can be associated with tic-like movements (Table 4). It is usually straightforward to differentiate these conditions with a thorough history and examination.
The physical examination includes careful examination for dysmorphic features to identify any indication of genetic syndromes. Unusual features may prompt specific genetic testing by consulting a clinical geneticist. Further, in the presence of additional learning difficulties or autism spectrum diagnosis it might be advisable to consult a clinical geneticist as well, as in some cases this high resolution array might reveal a rare genetic aetiology of these heterogeneous disorders.
Recent research has provided new insights into the neuropsychological profile of children with TS, mainly through direct comparisons between patients with comorbid ADHD, or, to a lesser extent, OCD, and patients with 'uncomplicated' TS, which represents a minority of the clinical population of children with TS. Although the majority of studies indicate that only TS patients with comorbid conditions exhibit cognitive dysfunction on standardised tests, the actual impact of having TS upon social and academic achievement, quality of life and the overall disability burden of the different subgroups of TS requires further study. For this reason, the prognostic value, and, as a consequence, clinical usefulness of formal neuropsychological testing in children with TS has not been clearly established to date, and most neuropsychometric tools seem appropriate, at present, only in research settings. However, it is useful to summarise the findings on cognitive performance in different subgroups of children with TS, and to identify tests that hold promise for standardised neuropsychometric assessment. Table 5 provides an overview of the test batteries suggested from published studies and more ecologically applicable screens (Fig. 1)..
Patients with 'uncomplicated' TS show barely any impairment on all the main areas of cognitive functioning [129–132]. It should also be noted that no ecologically valid measure of manual speed or dexterity (e.g. typing) has been evaluated in children with TS that shows practically relevant results. Of note, enhanced cognitive function has been identified on tasks of response inhibition in TS patients, with children with 'uncomplicated' TS showing enhanced cognitive control on an oculomotor switching task [133]. Authors suggest that this heightened ability to control inhibition may be a result of tic suppression over time. This finding needs confirmation in subsequent studies. In sum, based on current evidence, no specific clinical neuropsychological assessment is advised in children with 'uncomplicated' TS.
A body of evidence suggests that the main comorbid conditions, ADHD and OCD, have a detrimental influence on the cognitive performance of children with TS [134].
Children with TS + ADHD exhibit cognitive dysfunction. The main negative impact on cognitive performance seems determined by ADHD, independent of the coexisting tic disorder [131]. This might explain why comorbid ADHD is the main predictor of poorer psychosocial health [135, 136] and the main determinant of the burden of disability [137] in TS patients. However, it is unclear how much of the negative effects of ADHD on disability and social/academic functioning in TS patients is caused by ADHD-related intellectual dysfunction. ADHD comorbidity seems to impact on the general intellectual function of children with TS, as the majority of reports suggest that a lower Full-Scale IQ is accounted for by the presence of the comorbidity [138–140]. Moreover, learning disabilities and other problems concerning academic achievement are estimated to occur in approximately 23% of children with a diagnosis of TS and appear to be highly influenced by coexisting ADHD [140, 141]. Specifically, numerical skills [140] and written language [134] have been highlighted as prevalent in TS.
The performance on manual dexterity (Purdue Pegboard test) or visual-motor integration (Beery Visual-Motor Integration test) tasks does not differ significantly between patients with TS + ADHD and 'uncomplicated' GTS [132, 142, 143]. In line with children with ADHD only, children with TS + ADHD have been demonstrated to show marked impairment on visual attention (e.g. the Trail Making Test [144]) and sustained attention (Continuous Performance Tests; [132, 145]). Other cognitive domains in which children with TS + ADHD show impairments, compared to patients with 'uncomplicated' TS, are: planning skills [142, 146], response inhibition [131, 147, 148] and cognitive flexibility/set shifting [35, 148, 149]. The meaning of these cognitive impairments to predict outcome in children with TS remains inconclusive. However, the neuropsychological tests described here-above may provide clinically useful additional information on the cognitive profile of children with TS + ADHD.
There is very limited evidence on the neuropsychological profile of children with TS + OCD. It is unclear whether this comorbidity is associated with selective cognitive impairment in children with TS. The cognitive profile of OCD appears to be one of the primary executive dysfunctions, mainly affecting response inhibition and cognitive flexibility [150]. Although memory may be affected as well, these deficits are thought to be secondary to a failure of organisational strategies during encoding [150]. In line with this, patients with TS + OCD demonstrate executive function deficits primarily in response inhibition [151] and set shifting paradigms [152]. As underscored for the other two TS subgroups, information is lacking on the prognostic indicators of this dysfunction on social, academic and psychological wellbeing in children with TS + OCD. For TS + OCD patients, a neuropsychological assessment focused on executive function, primarily response inhibition and cognitive flexibility, may be clinically indicated.
To conclude, in children who are diagnosed with TS in combination with comorbid ADHD or OCD should undergo neuropsychological evaluation encompassing intellectual function, academic attainments, motor skills, attention, executive function and memory. Neuropsychological tests of certain test-batteries with good psychometric properties for the country in question are suggested from published studies and more ecologically applicable screens.
Tic disorders represent a wide range of tics and co-existing symptoms with a varied and heterogeneous presentation. In this guideline, we have recommended a broad range of assessments and investigations to capture the tic/TS phenotype, taking developmental issues into account. In our opinion, it is highly advisable to choose instruments that cover the whole age range between infancy and adulthood, so that the time course of symptoms across ages and life stages can adequately be captured. In most situations, a standard interview with a few additional questionnaires and rating scales are sufficient to guide diagnosis and treatment. However, psychiatric comorbidity occurs in more than three quarters of cases that are referred for specialised care. Further, in a minority of cases a more extensive neurological and psychiatric screen is necessary to differentiate tics from other hyperkinetic disorders and from psychogenic disorders. Finally, neuropsychological assessment can be useful because of the high concurrence of tics with learning disorders, especially in children who have not yet finished education or professional training.
Commercial firms and governmental organisations did not play a role in, or fund, the development of these guidelines. Tammy Hedderly, Jeremy S. Stern, Tara Murphy, Andreas Hartmann, Virginie Czernecki declare that they have no conflict of interest. Danielle C. Cath (last three years): Medical Advisory Board of Lundbeck, the Netherlands; Andrea Ludolph (last three years): she has received lecture fees from Janssen Cilag, and research funding from Novartis, she was/is involved in clinical trials with Böhringer Ingelheim, Eli Lilly, Janssen-Cilag; Mary Robertson has recently received a grant from the Tourette's Action-UK (Grant to support Dr AE Cavanna), she has also received honoraria from Janssen-Cilag, Eli Lilly, and has received Royalties for books from Blackwells Science, David Fulton/Granada/Taylor Francis, Oxford University Press and also Jessica Kingsley Publishers, she also sits on the Medical Advisory Board for the Italian Tourette SyndromeAssociation and The Tourette Syndrome Foundation of Canada; Davide Martino: honoraria for symposia from UCB Pharma, Chiesi Pharmaceuticals, Novartis, and Boehringer-Ingelheim.
Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Christos Androutsos, Harald Aschauer, Gillian Baird, Netty Bos-Veneman, Ariana Brambilla, Francesco Cardona, Danielle C. Cath, Andrea Cavanna, Virginie Czernecki, Sandra Dehning, Alan Eapter, Luca Farkas, Julia Gadaros, Andreas Hartmann, Elizabeth Hauser, Isabel Heyman, Tammy Hedderly, Pieter J. Hoekstra, Anne Korsgaard, Georgina M. Jackson, Linnea Larsson, Andrea G. Ludolph, Davide Martino, Claudia Menghetti, Nanette Mol Debes, Norbert Muller, Kirsten Muller-Vahl, Alexander Munchau, Tara Murphy, Richard Musil, Peter Nagy, Judith Nurnberger, Ben Oostra, Perry Paschou, Massimo Pasquini, Kirsten J. Plessen, Mauro Porta, Hugh Rickards, Renata Rizzo, Mary M. Robertson, Veit Roessner, Aribert Rothenberger, Domenico Servello, Liselotte Skov, Jeremy S. Stern, Gert Strand, Zsannett Tarnok, Cristiano Termine, Jolande Van der Griendt, Cara Verdellen, Veerle Visser-Vandewalle, Ebba Wannag, Tomas Wolanczyck.
Members of the ESSTS Guidelines Group are given in Appendix.
An erratum to this article can be found at http://dx.doi.org/10.1007/s00787-011-0195-z
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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