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The "New" G.O.P.!
Once upon a time, there was a Grand Old Party. They were for fiscal responsibility, limited government, strong defense, and racial equality*. But then, slowly, ever so slowly like the analogy of the frog in the boiling pot, they changed…
The Grand Old Party of yore, has now become the Gonadless Old Panderers. A party once represented by men such as Ronald Wilson Reagan, Eisenhower and can-we-really-even-flippin'-judge-NIXON these days, is currently represented by John Boehner, John McCain, Eric (not-that-old,-but-indulge-me) Cantor, and John Cornyn who voted for Obamacare. Grrrrr.
I think there must be some kind environmental insult or cause that is running rampant both in the Senate and the House. Whatever it is, apparently blocks the testosterone receptor hence lessening the effect of testosterone in the body. Symptoms are weakness, depression and fatigue. You see, what we may perceive as, "These guys just don't give a s*& anymore", could really be a cry for help.
Even as wonderful as Reagan was, he was too soft on immigration. So maybe it started waaaay back then, because we haven't had a Republican president ever since.
I hope this piece isn't to risque or inappropriate. I ran it past a fellow writer; a man with a lot of integrity to get his opinion. He said, "At least it's not Gonadless Old Perverts or Philanderers", I told him those are are generally Democrats. I think I'll become a "racist" Tea Partier now.
TagsG.O.P. Reagan republicans
Posting Policy
Truth is never risqué or inappropriate! Keep it up, patriot!
I left the R party about 10 years ago. When Bush 2 won in 2000 with a R Senate and a R House, I thought, "This is great! Now they can get everything done they've been talking about." But nothing changed, and in some ways they made things worse. So while I was glad to see the mid-terms swing back to the Rs, I was VERY skeptical. And for good reason: Their recent votes have
validated that they are merely a "light" variety of Socialists. Very sad that those of us who simply want a return to Constitutional government are considered radicals.
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Welcome to Scott Caan Web, your #1 online resource for news & images on actor/writer/director Scott Caan. Best known for his role as Detective Sergeant Danny Williams in CBS's hit drama, Hawaii Five-0. Also as Scott Lavin from Entourage, movies like the Ocean trilogy, Gone in Sixty Seconds & Enemy of the State. You'll find all the latest news, high quality photos and media on Scott. Check out the site and please come back soon.
1999 – Speed of Life
|Scott Caan as Drew
|Directed by: Rob Schmidt
Written by: Rob Schmidt
Produced by: Susan Shopmaker, Jonah Smith, Eric Watson
Production year: 1999
Original release: April 17, 1999 (USA)
Running time: 1 hour, 34 minutes
Other cast: Leo Burmester, Mia Kirshner, Anthony Ruivivar
A son is stuck with caring for his Alzheimer victim father, a former professor who can now barely communicate. Depressed and struggling to make ends meet, an old buddy tries to get him to become a pusher. He gets further drawn in by a wild girl for whom he does procure drugs and gets involved in a wild sexual relationship. All of these factors weigh on the man until the inevitable conclusion is reached.

subset: commoncrawl


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Human Resources Director
We are seeking an experienced, highly dedicated, compassionate leader to manage our strategic and operational HR plans, programs and processes, and to collaborate with our Chief Talent Officer on Talent Management Initiatives. If this is you, please keep reading; we'd like to hear from you!
Our Human Resources Director is responsible for executing all of the human resource functions of the organization for 160+ employees. Responsibilities include providing guidance and oversight on all aspects of employment with Rubicon, application of Rubicon's policies and practices, ensuring legal and regulatory compliance in employment practices, and serving as a trusted coach and advisor to managers and staff regarding human resources issues. This position reports to the General Counsel. The HR Director serves as Rubicon's Equal Employment Opportunity Officer.
1. Manage HR strategic and operational plans, programs and processes, including:
- All aspects of the employee lifecycle, including hiring processes, job descriptions and postings, applicant tracking, employee relations, and performance management processes.
- Affirmative Action, ADA, FMLA, Workers Compensation and compliance with other federal and state regulations and employment laws.
- Compensation and benefits, including maintaining the integrity of the salary structure.
- Guiding management teams in HR matters and participating in coaching, disciplining and terminating employees.
2. Maintain, update, and ensure implementation of HR Policies, programs and systems for the overall operation and effectiveness of the organization; this will include the employee handbook, the HRIS database, and executive level reports for critical analyses of the HR function and the people resources of the organization.
3. Collaborate with the Chief Talent Officer on Talent Management initiatives in areas of overlapping responsibility. These areas may include:
- Recruitment, performance management; design of professional development programs; retention practices
- Succession planning
- Development of career lattices and strategies to support employee growth and development within Rubicon; implementation of strategies.
* To perform successfully, an individual must be able to perform each essential duty satisfactorily. The responsibilities listed are representative of the knowledge, skill and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform these duties.
Competitive benefits include: Kaiser HMO/HSA medical, MetLife dental, VSP vision service plan, generous paid sick leave and our company sponsored 403(b) retirement plan. Eligible employees also earn paid personal days, up to 3 weeks (annualized) paid vacation in the first three years and up to 4 weeks (annualized) thereafter, plus 10 company holidays.
- Comprehensive HR expertise in employment law, EEO guidelines, employee management, health and welfare benefit programs, and full cycle recruiting.
- Outstanding interpersonal and relationship management skills. Ability to effectively collaborate with multiple diverse parties throughout organization.
- Experience and desire to effectively engage employees through coaching, advising and mentoring.
- Business acumen, successful leadership experience and excellent communication and consultation skills.
- Commitment to Rubicon's values, mission and communities. High degree of cultural responsiveness, cultural humility and professional integrity. Commitment to HR ethical and professional standards.
- This position requires the incumbent to travel efficiently throughout the Bay Area therefore proof of a valid driver license, current auto insurance, and an acceptable Motor Vehicle Report are required.
To Apply
To apply, please complete and email the following to email@example.com
- Your cover letter describing your interest in, and qualifications for this position
- Rubicon Applicant Tracking Form: http://rubiconprograms.org/assets/uploads/page/RubiconApplicantTrackingForm.pdf
Please Note: Submissions lacking either of the two documents above may not be considered; thank you for understanding.
This position is open until filled and may be closed at any time. We are an Equal Employment Opportunity/Affirmative Action, Veteran Friendly Employer and we utilize E-Verify to validate right to work within the United States. If interested please let us know! Thank you.


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Bringing self-driving cars to NASCARSubmitted by srlinuxx on Sunday 1st of April 2012 09:10:14 PM Filed under
- Bringing self-driving cars to NASCAR
- Begin your quest with Google Maps 8-bit for NES
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Torvalds Awards Arch The Most User-FriendlySubmitted by srlinuxx on Sunday 1st of April 2012 07:46:08 PM Filed under
muktware.com: Arch Linux has won the Free Software Award for the Most Consumer Friendly Linux Distribution. Aaron Griffin recieved the award from Richard M. Stallman and Linus Torvalds at the LibrePlanet conference at the University of Massachusetts, Boston.
Justin Bieber Linux 'Biebian' Becomes The Most PopularSubmitted by srlinuxx on Sunday 1st of April 2012 07:37:33 PM Filed under
techlaze.com: It's not just teenage girls who are swept away by 'bieber fever', apparently Linux, the open-source operating system is the newest entrant to the overflowing list of beliebers.
Leaked: Microsoft Office 2013 For Linux ScreenshotSubmitted by srlinuxx on Sunday 1st of April 2012 07:36:15 PM Filed under
thepowerbase.com: Last night at 1:30am EST, we received a surprise tip from faithful reader Chaucer. Chaucer will not reveal his true identity for obvious reasons, though he does want to make it known that this screenshot was leaked from Microsoft's Canterbury campus.
Richard Stallman To Launch His Own Fashion LineSubmitted by srlinuxx on Saturday 31st of March 2012 11:06:21 PM Filed under
techlaze.com: After making massive neckbeards a universal style statement, Richard Stallman, revered software freedom activist and computer programmer, has turned to the world of fashion. His new collection, titled RMS, is a luxury line of clothing specially designed for geeks and programmers.
Xfce's Early April Fool's JokeSubmitted by srlinuxx on Saturday 21st of January 2012 05:12:40 AM Filed under
ostatic.com: I saw a post on the Xfce blog Tuesday or Wednesday about changing versioning scheme of the next Xfce release. I saved the URL knowing that I'd want to write about it. Just thank goodness that a storm blew in and caused my computer to shut off. Otherwise, I might have never seen the Update 2. Dirty rats!
Linux from Scratch: I've had it up to here!Submitted by srlinuxx on Tuesday 29th of November 2011 01:25:09 AM Filed under
thelinuxexperiment.com: As you may be able to tell from my recent, snooze-worthy technical posts about compilers and makefiles and other assorted garbage, my experience with Linux from Scratch has been equally educational and enraging.
"I'm a Beefy Miracle" songSubmitted by srlinuxx on Tuesday 11th of October 2011 05:17:32 PM Filed under
larrythefreesoftwareguy.wordpress: Beefy Miracle was chosen as the release name for the May 2012 edition of Fedora. Being a man of my word, here is my version of the song.
Top 10 Runlevels for Windows 8Submitted by srlinuxx on Thursday 22nd of September 2011 05:50:50 PM Filed under
fossforce.com: You heard the news, we're sure, that Ballmer & Company unveiled a preview of Windows 8 this week. We FOSS types couldn't help but notice that the upcoming Windows operating system mimics the penguin.
DtO: Every Linux desktop user can identify...Submitted by srlinuxx on Tuesday 20th of September 2011 06:04:20 PM Filed under
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B2 tlsb -0.016w?>Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease caused by both genetic and environmental factors. A substantial genetic component to SLE is supported by data demonstrating high heritability of the disease, a higher concordance rate of SLE in monozygotic twins than dizygotic twins or siblings and a high sibling recurrence risk ratio (that is, greater likelihood of disease, given that one's sibling is affected, compared with disease prevalence in the general population).1 The strongest genetic risk factor established for SLE resides within the major histocompatibility complex (MHC) on chromosome 6, where HLA-DRB1*03:01 and other MHC variants have been strongly implicated.2, 3 Recent genome-wide association studies have also identified more than 40 independent loci related to SLE onset.4 A weighted genetic risk score (GRS) comprising these variants was significantly higher on average in SLE cases compared with healthy controls.5 However, measures of association between genetic variants and SLE are generally modest (with odds ratios ranging from 1.1 to 2.3), gene–environment interactions are poorly understood and there is little awareness of how genetic profiles have an impact on disease activity.1, 6
Autoimmune diseases such as SLE are commonly treated with immunosuppressive therapy, and large efforts are dedicated to the development of targeted therapies such as biologic agents.7 In order to accurately determine the effect of treatment, it is critical to understand the factors that influence variation in disease activity, including genetic susceptibility. Whereas genetic risk has been demonstrated to be associated with disease onset, the extent to which it is associated with disease activity over time has not been extensively studied. Previous studies have found significant associations between individual gene variants and more severe clinical SLE characteristics, such as production of antibodies against double-stranded DNA (ds-DNA), nephritis and early age at diagnosis.8 One study found that a weighted GRS comprising 22 SLE risk loci demonstrated significant associations with ds-DNA, immunologic disorder, renal disorder, hematologic disorder and early age at diagnosis.5 Further, understanding of how genetic variants influence disease activity may lead to personalized, targeted treatments for patients with SLE.1 This study aimed to examine clinically important marginal effects of a GRS composed of 41 established genetic risk loci on disease activity over a period of 9 years, accounting for time-dependent confounding of missing visits, in a multiethnic cohort of SLE patients. We were also interested in conducting individual single-nucleotide polymorphism (SNP) analyses in order to determine whether specific genetic variants were associated with disease activity.
Demographic and disease characteristics are shown in Table 1. Over 90% of study participants were female, which is consistent with the striking female predominance of the disease. The mean age of participants at enrollment was 56.2 (±13.6) years, with the mean disease duration of 9.1 (±8.3) years and average age at diagnosis of 33.5 (±13.0). The mean follow-up time for participants was 6.7 (±2.7) years. The average Systemic Lupus Activity Questionnaire (SLAQ) score at baseline was 12.5 (±7.9). Treatment of patients included plaquenil (56%), oral prednisone or other glucocorticoid (46%), other disease-modifying therapies (31%), cyclophosphamide or cholorambucil (3%), or biologics (1%).
Table 2 shows estimated marginal difference in the expected self-reported SLAQ score for participants with a high GRS (33.0, the median GRS) versus a low GRS (<33.0) after controlling for sex, ancestry, disease duration, renal transplant status, dialysis, treatment, depression, smoking and education. No consistent clinically important difference of SLAQ score between groups was demonstrated throughout the 9 years of follow-up period (Figure 1). Additional analyses examining the association of GRS without the HLA-DRB1*03:01 allele tag SNP on expected SLAQ score showed similar results (data not shown). Analyses excluding renal transplant status or dialysis to further assess any evidence of collinearity of these variables also reflected similar results (data not shown). Analyses of the GRS based on extremes (that is, the first and fourth quartiles) indicated no clinically important difference of SLAQ score between groups throughout the follow-up period after controlling for covariates (Supplementary Table 1). Analyses examining the effect of GRS extremes without the HLA-DRB1*03:01 on SLAQ score were similar (data not shown).
Figure 1.
Genetic risk score (GRS) and longitudinal clinically significant disease activity.Full figure and legend (41K)
Table 2 - Estimates of the marginal association of GRS and disease activity (SLAQ score) among individuals over study period.Full table
Individual SNP analyses demonstrated that clinically meaningful SLAQ score differences were observed for two SNPs at time point 8 and ten SNPs at time point 9 after adjusting for covariates and correcting for multiple testing (Table 3). Eight of the twelve risk SNP associations were associated with an increased SLAQ score, indicating higher disease activity. We found no significant association between DRB1*03:01 and SLAQ score at any of the time points.
Table 3 - Estimates of the clinically important marginal associations of individual SNPs and disease activity (SLAQ score) among individuals over study period .Full table
Our study describes the first longitudinal study examining how genetic factors influence disease activity in a large multiethnic cohort of individuals with SLE. Using a robust method of statistical analysis, our findings do not support a strong causal relationship between an overall GRS comprising established SLE SNPs and disease activity as measured by the validated self-reported SLAQ. Whereas results from analyses of the GRS and SLAQ score provided some evidence for an inverse relationship at years 1–5, the magnitude of these SLAQ score differences is not within the range established as clinically important.9 Results from individual SNP analyses provide important insight to the overall GRS findings; specifically, evidence for significant associations between certain SNPs and SLAQ score at two time points during the longitudinal study was demonstrated. Some SLE risk alleles were associated with an increased SLAQ score, whereas others were associated with a decreased SLAQ score. Of the 41 SNPs tested across various time points, 12 were associated with clinically significant SLAQ score differences. Score differences varied, depending on risk SNP tested, and help to explain the overall null findings that were observed when all risk SNPs were considered as a single combined GRS. More work is needed to further clarify the relationship between established SLE risk variants and patterns of disease activity for clinical outcomes that the SLAQ may or may not capture.
Previous studies have found significant associations between specific gene variants and SLE disease characteristics, which capture severity, not specifically activity. Allele 2 of the IL1RN polymorphism was associated with SLE disease characteristics as defined by discoid rash and photosensitivity.10 In a Danish study, the MBL2 gene was associated with an increased risk of sustained disease activity and a tendency to acquire infection, but not identified as a susceptibility locus.11 Taylor et al. also concluded that a common polymorphism within STAT4 was associated with more severe SLE characteristics, including production of antibodies against ds-DNA, nephritis and age at diagnosis.8 Status for ds-DNA, which can fluctuate over time with disease activity or severity,12, 13, 14 was previously associated with the HLA-DRB1*15:01 allele,12 as well as ITGAM, UBE2L3 and HLA-DRB1*03:01.5 Although we did not find a significant association between HLA alleles or risk variants in ITGAM and SLAQ score across time points, we did observe a clinically important difference in disease activity for those carrying one to two copies of a risk allele in UBE2L3 (rs5754217) at time point 9. An earlier investigation reported significant associations between a weighted GRS comprising 22 SLE risk loci and several SLE-related clinical manifestations including ds-DNA, immunologic disorder, renal disorder, hematologic disorder and early age at diagnosis in individuals of European ancestry.5 Whereas previous studies support the influence of genetics on certain SLE outcomes, our study is the first to examine the relationship between a 41-SNP GRS and SLAQ score as a measure of disease activity.
Some differences in findings between previous studies of disease severity measured by ds-DNA status and disease activity measured by SLAQ score in the current study may be explained by the self-reported nature of the SLAQ score, which could be influenced by a number of factors that were not measured or appropriately controlled for in our analysis. We found SLAQ score within individuals to be highly variable over time, indicating that it may be driven by characteristics not closely linked to genetics, such as psychosocial and other biological factors. Indeed, previous studies have demonstrated that specific factors such as age, sex, income, education, as well as presence of renal and lung diseases are associated with SLAQ scores.9, 15 Our results indicate primarily a nonlinear and clinically nonsignificant relationship between the GRS and SLAQ after controlling for these other factors, suggesting that established genetic risk factors for developing SLE, when considered together, do not have a major role in disease activity, at least as measured with the SLAQ score. However, we identified specific genetic variants through individual SNP analysis causally associated with disease activity, even after correction for multiple testing.
Strengths of this study include the application of causal methods to an important research hypothesis focused on a comprehensive, validated clinical outcome instrument for SLE. Traditional longitudinal methods, such as simple random effects models, are likely to be subject to bias from time-dependent confounding: time-varying covariates that could influence variation in disease activity and the measurement process, and that are also affected by the baseline exposure.16 However, using our approach, we were able to much better control for these covariates using longitudinal-targeted maximum likelihood estimation (L-TMLE). Additional studies examining the extent to which the GRS is associated with other measures of disease activity using methods that account for time-varying covariates are warranted; our current study is a model of how future investigations can be approached. Our study also focused on a large number of established genetic variants for SLE risk with large effect sizes.
In addition, the current study included a large, multiethnic group of individuals, which is important for external validation of our findings. Although power was limited for analyzing each race/ethnicity group separately, overall results were consistent when the study sample was restricted to Caucasian participants only (controlling for intra-European principal components), the largest group in our patient cohort. Further, we do not present analyses stratified by ancestry because of the fact that the GRS was predominately derived from risk alleles associated with SLE in European populations and may under-represent relative genetic risk of non-Europeans. Future studies examining other populations using population-specific SLE risk alleles are needed.
Study limitations include examination of the GRS as a binary variable in the statistical model, which is unlikely to fully capture the relationship between the GRS values and shifts in disease activity. However, extreme quartiles were utilized for analyses and comparable finding were demonstrated. Further, use of a binary variable reduces the increased likelihood of positivity violations and extrapolation that would occur when using a continuous variable. Additional risk SNPs will no doubt be identified through larger genome-wide association studies in SLE, and pathway analysis may soon inform subscore development for future longitudinal studies of a GRS and disease activity in SLE. Additional limitations include reliance on prevalent cases to estimate effects over time, self-report of symptoms in the SLAQ score and imputation of missing covariates using the last value forward method. We also accounted for informative measurement (that is, selection bias) as well as possible given data; however, there may be additional unmeasured time-dependent covariates that influence whether or not a participant was interviewed at time t. In other words, the sequential randomization assumption may not hold for the measurement process.16 There was some attrition over the 9-year follow-up period. Whereas we controlled for the potentially informative measurement process with L-TMLE, the wider confidence intervals at later time points reflect, in part, the fewer number of individuals interviewed in the later years of the study, which may also contribute to a higher potential for positivity violations.
In summary, SLE is a multifactorial disease with both genetic and environmental risk factors. In line with previously demonstrated associations of genetic factors with disease severity, for example, ds-DNA status as examined in other studies,5, 12, 13, 14 we observed evidence of clinically important differences in SLAQ scores for individual SNPs. We did not observe a clinically important association of the overall GRS with disease activity as measured by the SLAQ score, which highlights the strong potential for heterogeneous genetic effects influencing disease activity over time. Genetic susceptibility appears to have a role in the development of SLE, as well as some measures of disease activity and severity. However, other biological and unknown environmental factors may also contribute significantly to disease activity. Future work to identify specific patient subgroups based on genetic and environmental factors and the development of corresponding targeted treatment interventions is needed, and has the potential to improve SLE symptoms.
Materials and methods
Data were collected from participants of the Lupus Outcome Study at the University of California, San Francisco. This longitudinal cohort study was designed to prospectively investigate health and quality of life outcomes in a set of SLE patients who were also participants in a larger study of SLE genetic risk factors and outcomes.8, 17 Participants were followed from January 2004 to December 2012. Study methodology and details have been reported previously.18, 19 Participants had a diagnosis of SLE confirmed by medical record review by a rheumatologist or a nurse working under a rheumatologist's supervision. The cohort was composed of 942 individuals self-identified as Caucasian, African American, Hispanic, Asian or mixed race/ethnicity. The Committee on Human Research at University of California, San Francisco approved this study, and all participants provided informed consent before enrollment.
Data collection
Participants completed up to nine annual structured telephone interviews comprising questions related to various events and exposures. Disease activity was measured by a validated comprehensive self-reported measure, the SLAQ. The SLAQ identifies clinical outcomes such as disease symptoms including weight loss, fatigue, fever, skin rash, vasculitis, alopecia, lymphadenopathy, shortness of breath, chest pain with deep breath, Raynaud's, abdominal pain, stroke syndrome, seizures, forgetfulness, depression, headache, muscle pain, muscle weakness, joint pain or stiffness and joint swelling.9, 20 Items were weighted and aggregated into a scoring system, resulting in scores ranging from 0 to 47, with higher scores indicating greater disease activity over the prior 3 months. A conservative estimate of the minimal clinically important difference for SLAQ score in the current study was considered to be 4.0 points, as previously indicated.9
Participants were genotyped using the Illumina Immunochip platform.21 Quality-control procedures included removal of subjects for low genotyping (<5%), sex mismatch and relatedness (first degree as determined by identity-by-descent analysis). A GRS was calculated for each individual from 41 established SLE susceptibility loci (Supplementary Table 2)5, 14, 22, 23, 24, 25, 26, 27, 28, 29 with proxies if available for SNPs not genotyped on the Immunochip. The GRS was calculated by summing the number of independent risk alleles for each locus across the 41 loci; missing genotypes (<5%) were assumed to be the most frequent genotype. We also calculated a GRS without HLA-DRB1 (DRB1*03:01 allele tag SNP, rs2187668),3 the strongest genetic predictor of SLE, to examine whether this factor had a major influence on the GRS.
Study data included sex and disease duration (as calculated by age at time of interview minus age at diagnosis). Renal transplant and dialysis status at time of interview were self-reported (yes/no), and depression was measured using the Center for Epidemiologic Studies Depression scale.30 Treatment was categorized as type of medication at time of interview: oral prednisone or other glucocorticoid; plaquenil; or other (including biologics (etanercept, rituxan, belimumab, anakinra, infliximab, adalimumab or abatacept); cyclophosphamide or chlorambucil; or other disease-modifying therapies (methotrexate, cyclosporine, leflunomide, mycophenolate mofetil, tacrolimus or sulfasalazine)). Genetic ancestry was represented by the top four principal components determined with EIGENSTRAT using 878 independent (r2<0.2) Immunochip SNPs.
Statistical analyses
L-TMLE was used to estimate the marginal association of the GRS on SLE disease activity during the 9-year observation period.31 L-TMLE allows for estimation of the cumulative genetic impact of the baseline exposure (GRS) while accounting for time-varying covariates and non-monotone observation process.32 Despite the study's best efforts, cohort members occasionally missed their yearly interviews; however, individuals did not generally miss more than 2 years in a row. Instead of censoring at the time of the first missed interview (which would substantially reduce the data set), L-TMLE was used to control for the possibly informative measurement process, that is, to account for missing time points (interviews) that may have been influenced by time-varying covariates.
Our primary research question aimed to examine the causal effect of the GRS on clinically important disease activity as measured by SLAQ score at each time point (year) t while accounting for the observation process. Let A be an indicator that patient had a GRS above the median in the data set and Δt be an indicator that the patient was interviewed at time t. Our causal parameter was the expected difference in the counterfactual SLAQ score at time t if all patients had high versus low GRS and were interviewed at time t: E[Yt(A=1, Δt=1)−Yt(A=0, Δt=1)], where Yt(A=a, Δt=1) is the counterfactual outcome at time t if possibly contrary-to-fact the patient's GRS was A=a and he/she was interviewed at time t Δt=1.33 The time-dependent covariates (disease duration, depression, treatment, smoking status, dialysis, renal transplant status and education) may affect both the outcome Yt as well as observation process Δt. These covariates are also influenced by the exposure GRS A. Therefore, time-dependent confounding is present and standard regression methods are likely to yield biased estimated, even though exposure GRS is randomized within sex-ancestry strata.16, 34, 35 However, more sophisticated methods allow us to estimate the statistical parameter, best approximating our causal parameter of interest.
Our statistical estimand was the longitudinal G-Computation formula,16 which will equal our causal parameter if the needed assumptions are met. Specifically, we need the sequential randomization and positivity assumptions to hold: that is, at each time t, the counterfactual outcome Yt(A=a, Δt=1) is independent of the observation process at t, given the measured past, and there is a positive probability of being observed (Δt=1) within all covariate–measurement histories. Furthermore, by incorporating data-adaptive methods, L-TMLE is able to minimize the potential bias because of regression model misspecification and maximize precision of the estimates. In this analysis, Super Learner was used to build the best-weighted combination of candidate algorithms as measured by the cross-validated mean squared error.36 The library of candidate prediction algorithms in Super Learner included linear regression; linear regression with interactions; the mean; stepwise regression; and stepwise regression with interactions.
For comparison, we also examined the association of being in the most extreme quartiles of GRS on average SLAQ score. Specifically, we defined the patient as exposed (A=1) if he/she had a GRS in the upper 25 percentile and as unexposed (A=0) if he/she had a GRS in the lower 25 percentile. Again, we adjusted for potentially informative measurement, baseline confounders (sex and ancestry), and accounted for time-dependent confounding.
We tested the association between the GRS (above or below the median and in the extreme quartiles) and disease activity as measured by SLAQ across nine time points: baseline (T1) and eight additional time points (T2–T9). We were specifically interested in SLAQ differences between the two groups that were clinically meaningful (greater than 4.0 points).9 We examined each time point separately to better control for informative missingness by using time-updated covariates to fit the observation status at time t, and because disease activity in SLE patients varies both between and within individuals over time.37 We restricted the sample to the subset of participants who had no complete missingness (that is, missing values at all time points) for the following variables: sex, ancestry as measured by EIGENSTRAT principal components, disease duration, depression, treatment, smoking status, GRS, dialysis, renal transplant status and education (n=903). An assessment of multicollinearity between these variables was conducted by examining variance inflation factors; all variables were retained (variance inflation factors1.2). For missing values of the data that remained in the subset of 903 individuals (<3% for each variable), information was imputed using last value carried forward. As described above, individuals with missing outcomes (SLAQ score) were accounted for by conditioning on the observation process (Δt).
Owing to the limitation of a binary GRS and inability to determine whether specific genetic variants are associated with disease activity, we also conducted individual SNP analyses. We defined the patient as exposed (A=1) if he/she carried 1-2 risk alleles and as unexposed (A=0) if he/she carried 0 risk alleles for each SNP, and adjusted analyses for potentially informative measurement, baseline confounders and accounted for time-dependent confounding. Individual SNP analyses were corrected for multiple testing using Bonferroni adjustment. All analyses were conducted with the 'ltmle' package in R v3.2.0 (www.r-project.org).38 We created 95% confidence intervals and conducted two-sided hypothesis tests controlling the type I error rate at 5% (α=0.05).
Conflict of interest
The authors declare no conflict of interest.
- Deng Y, Tsao BP. Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 2010; 6: 683–692. | Article | PubMed | ISI | CAS |
- Morris DL, Taylor KE, Fernando MM, Nititham J, Alarcon-Riquelme ME, Barcellos LF et al. Unraveling multiple mhc gene associations with systemic lupus erythematosus: model choice indicates a role for hla alleles and non-hla genes in europeans. Am J Hum Genet 2012; 91: 778–793. | Article | PubMed | ISI | CAS |
- Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J et al. High-density snp screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet 2009; 5: e1000696. | Article | PubMed | CAS |
- Bentham J, Morris DL, Cunningham Graham DS, Pinder CL, Tomblesson P, Behrens TW et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet 2015; 47: 1457–1464. | Article | PubMed | CAS |
- Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD et al. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet 2011; 7: e1001311. | Article | PubMed | CAS |
- Gualtierotti R, Biggioggero M, Penatti AE, Meroni PL. Updating on the pathogenesis of systemic lupus erythematosus. Autoimmun Rev. 2010; 10: 3–7. | Article | PubMed | ISI | CAS |
- Luijten KM, Tekstra J, Bijlsma JW, Bijl M. The systemic lupus erythematosus responder index (sri); a new SLE disease activity assessment. Autoimmun Rev 2012; 11: 326–329. | Article | PubMed |
- Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C et al. Specificity of the stat4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet 2008; 4: e1000084. | Article | PubMed | CAS |
- Yazdany J, Yelin EH, Panopalis P, Trupin L, Julian L, Katz PP. Validation of the systemic lupus erythematosus activity questionnaire in a large observational cohort. Arthritis Rheum 2008; 59: 136–143. | Article | PubMed |
- Blakemore AI, Tarlow JK, Cork MJ, Gordon C, Emery P, Duff GW. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum 1994; 37: 1380–1385. | Article | PubMed | ISI | CAS |
- Garred P, Voss A, Madsen HO, Junker P. Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients. Genes Immun 2001; 2: 442–450. | Article | PubMed | CAS |
- Podrebarac TA, Boisert DM, Goldstein R. Clinical correlates, serum autoantibodies and the role of the major histocompatibility complex in french canadian and non-french canadian caucasians with SLE. Lupus 1998; 7: 183–191. | Article | PubMed |
- Hanaoka H, Okazaki Y, Satoh T, Kaneko Y, Yasuoka H, Seta N et al. Circulating anti-double-stranded DNA antibody-secreting cells in patients with systemic lupus erythematosus: a novel biomarker for disease activity. Lupus 2012; 21: 1284–1293. | Article | PubMed |
- Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsdna autoantibody production. PLoS Genet 2011; 7: e1001323. | Article | PubMed | CAS |
- Trupin L, Tonner MC, Yazdany J, Julian LJ, Criswell LA, Katz PP et al. The role of neighborhood and individual socioeconomic status in outcomes of systemic lupus erythematosus. J Rheumatol 2008; 35: 1782–1788. | PubMed |
- Robins JM. A new approach to causal inference in mortality studies with a sustained exposure period-application to control of the healthy worker survivor effect. Math Model 1986; 7: 1393–1512. | Article |
- Thorburn CM, Prokunina-Olsson L, Sterba KA, Lum RF, Seldin MF, Alarcon-Riquelme ME et al. Association of pdcd1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun 2007; 8: 279–287. | Article | PubMed | CAS |
- Yelin E, Trupin L, Katz P, Criswell L, Yazdany J, Gillis J et al. Work dynamics among persons with systemic lupus erythematosus. Arthritis Rheum 2007; 57: 56–63. | Article | PubMed |
- Panopalis P, Julian L, Yazdany J, Gillis JZ, Trupin L, Hersh A et al. Impact of memory impairment on employment status in persons with systemic lupus erythematosus. Arthritis Rheum 2007; 57: 1453–1460. | Article | PubMed |
- Yazdany J, Trupin L, Gansky SA, Dall'era M, Yelin EH, Criswell LA et al. Brief index of lupus damage: a patient-reported measure of damage in systemic lupus erythematosus. Arthritis Care Res (Hoboken) 2011; 63: 1170–1177. | Article | PubMed |
- Parkes M, Cortes A, van Heel DA, Brown MA. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 2013; 14: 661–673. | Article | PubMed | ISI | CAS |
- Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S et al. Association of systemic lupus erythematosus with c8orf13-blk and itgam-itgax. N Engl J Med 2008; 358: 900–909. | Article | PubMed | ISI | CAS |
- Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in itgam, pxk, kiaa1542 and other loci. Nat Genet 2008; 40: 204–210. | Article | PubMed | ISI | CAS |
- Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z et al. Genome-wide association study in a chinese han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1234–1237. | Article | PubMed | ISI | CAS |
- Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1228–1233. | Article | PubMed | ISI | CAS |
- Yang J, Yang W, Hirankarn N, Ye DQ, Zhang Y, Pan HF et al. Elf1 is associated with systemic lupus erythematosus in Asian populations. Hum Mol Genet 2011; 20: 601–607. | Article | PubMed | ISI | CAS |
- Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW, Wilson AG et al. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 2011; 70: 463–468. | Article | PubMed | ISI |
- Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E et al. Functional variants in the b-cell gene bank1 are associated with systemic lupus erythematosus. Nat Genet 2008; 40: 211–216. | Article | PubMed | ISI | CAS |
- Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM et al. Genetic variants near tnfaip3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008; 40: 1059–1061. | Article | PubMed | ISI | CAS |
- Eaton W, Muntaner C, Smith C, Tien A, Ybarra M. Center for Epidemiologic Studies Depression Scale: Review and Revision (CESD and CESD-R). In: Maruish ME (ed.). The Use of Psychological Testing for Treatment Planning and Outcomes Assessment, 3rd ed. Lawrence Erlbaum: Mahwah, 2004, pp 363–377.
- Petersen M, Schwab J, Gruber S, Blaser N, Schomaker M, van der Laan M. Targeted maximum likelihood estimation for dynamic and static longitudinal marginal structural working models. J Causal Inference 2014; 2: 147–185. | Article | PubMed |
- van der Laan MJ, Gruber S. Targeted minimum loss based estimation of causal effects of multiple time point interventions. Int J Biostat 2012; 8.
- Pearl J. Causality: Models, Reasoning and Inference. 2nd edn. Cambridge University Press: : New York, NY, USA, 2009.
- Taubman SL, Robins JM, Mittleman MA, Hernan MA. Intervening on risk factors for coronary heart disease: an application of the parametric g-formula. Int J Epidemiol 2009; 38: 1599–1611. | Article | PubMed |
- Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11: 550–560. | Article | PubMed | ISI | CAS |
- van der Laan MJ, Polley EC, Hubbard AE. Super learner. Stat Appl Genet Mol Biol 2007; 6: Article 25.
- Mikdashi J, Nived O. Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research. Arthritis Res Ther 2015; 17: 183. | Article | PubMed |
- Schwab J, Lendle S, Petersen M, van der Laan M ltmle: Longitudinal targeted maximum likelihood estimation. R package version 0.9.3-1. http://CRAN.R-project.org/package=ltmle Published 22 April 2014.
We thank Sam Lendle and Josh Schwab for their assistance with the L-TMLE software, as well as Maya Petersen, Alex Luedtke and Alice Baker for their thoughtful feedback. We also thank Paola Bronson for her assistance in developing the genetic risk score, and Lily Hoang for her help with this project. This work was supported by the Lupus Foundation of America (to MAG); Rheumatology Research Foundation (to MAG); National Institutes of Health (Grants P60 AR053308 and K24-AR-02175 to LAC); University of California, San Francisco General Clinical Research Center (Grant R01-AR-44804 to LAC); National Center for Advancing Translational Sciences (Grant UL1-TR-000004 to LAC); and Alliance for Lupus Research (to LAC).
Supplementary Information accompanies this paper on Genes and Immunity website


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Gypsum community clean up day Saturday
May 9, 2014
if you go …
What: Gypsum community clean-up day.
When: 8 a.m. to 12 p.m. on Saturday.
Where: Gypsum Sports Complex parking lot.
Cost: Free dumping. There is a $5 minimum for shredding and a $15 per box price. Proceeds fo to the Gypsum Fire Department.
More information: Contact Krista DeHerrera, special projects coordinator, with questions about this event at 970-524-1727, or email@example.com.
GYPSUM — It's spring clean-up time again and the Town of Gypsum encourages residents to bring your unwanted items to the Sports Complex parking lot Saturday from 8 a.m. to 12 p.m. for free dumping and a shred-a-thon to support the Gypsum Fire Department. In addition, community volunteers are encouraged to roll up their sleeves and join town staff in picking up trash and recyclables in our neighborhoods that morning.
The community dump site at the Sports Complex parking lot will have dumpsters for household trash, tires (limit four) and yard items. In addition, Trinity Recycling will be on site for metal, appliance and electronic recycling. Habitat for Humanity will have a truck to take unwanted furniture in good condition. The town is limiting dumps to one truck/trailer load per household and no business waste please. Residents must bring an ID showing proof of residency and be prepared to unload your own truck.
The Gypsum Fire Department is hosting a document shredding booth at the Sports Complex parking lot. There is a $5 minimum for shredding and a $15 per box price. All proceeds go toward the 2014 equipment replacement fund.
Once you have dropped off your unwanted items, join staff and other community members in our neighborhood clean-up. Participants can meet town staff at 9 a,m. in the Town Annex building off Cooley Mesa Road. Gloves and trash bags, provided by the Town of Gypsum Department of Public Works, will be supplied to all community volunteers. Volunteers will be treated to doughnuts and coffee before they are teamed up and dispersed into neighborhoods to pick up trash and recyclables. Businesses and organizations are encouraged to form their own teams and join us as well. Typically, the clean-up does not last longer than a couple of hours. Following the clean-up, the Town of Gypsum will provide lunch back at the Annex Building.
Contact Krista DeHerrera, special projects coordinator, with questions about this event at 970-524-1727, or email@example.com.
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Bert has been handled regularly since birth. He has had consistent farrier care. Lessons include desensitizing, basic halter skills, backing, flexing…$3,000
**New Video Link Added 05/11/17** Yes This Is It aka "Blake" is a lovely uphill built and well muscled 9 year old, 17 hand OTTB gelding. He looks and…$25,000
If you are looking for a horse to take through the upper levels this is your guy! He has successfully competed through training level eventing with impressive…$15,000
RS Alegre is an easy going Paso who likes to jump, trail rides in groups or alone, and competes in gaited dressage. Alegre plays E grade polocrosse.…$5,000
American Star Farm is looking to reduce its herd. Broodmares, 2 year old fillies that are ready to start training and yearlings are available. All are…Make an Offer
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Hotsy is a 6 year old Morgan mare started w/t/c and is proving to be an extremely trustworthy mount. (Merlin Royal Night Hawk x A.E.B. Novel Topic). She…No Price Listed


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BFC – Bahrain's leading exchange house has tied up with 104.2 Your FM
The entire team of 104.2 Your Fm wishes all its listeners and well-wishers Eid Mubarak!
Tune into the Special Ramadan Programmes everyday during this holy month at 4pm (for Malayalam) and at 5pm (for Hindi).
The Chairman of 104.2 Your FM, Shaikh Hamad bin Khalifa Al Khalifa and the entire team take this opportunity to thank all the listeners for their support...
All of us here at 104.2 Your FM wishes one and all a very Happy & Prosperous New Year! Keep listening to Your FM in 2014


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If you will live like no one else, later you can live like no one else.
Dave Ramsey QuotesShowing all quotes
Dave Ramsey (3)
|3rd September, 1960
|Author, Radio Personality
Dave Ramsey was born in Antioch, Tennessee. He is an American financial author and radio host. His show and writings strongly focus on encouraging people to get out of debt. Ramsey's syndicated radio program, The Dave Ramsey Show, is heard on more than 500 radio stations throughout the United States and Canada, in podcast format, on IHeartRadio, a dedicated iOS application, as well as live audio and video on DaveRamsey.com. He has written numerous books including five New York Times bestsellers. He has been featured on many media outlets including The Oprah Winfrey Show, 60 Minutes, and The Early Show on CBS.
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Entire home/apt
7 Guests
3 Bedrooms
4 Beds
Entire home/apt
7 Guests
3 Bedrooms
4 Beds
About this listing
One mile from the center of Amherst on a sustainable working family farm. Visit our animals, hike our fields, forest and streams, or simply relax.
Master Suite with kitchen and bath, plus 2 additional bedrooms.
The space
A graceful blend of the old and new near the heart of Amherst. Maybe you just want the master suite, but we can accommodate larger families and groups by adding one, or two more private bedrooms. Sleeps up to 7.
A private front porch opens to the entrance foyer and staircase. Upstairs is the master suite/apartment (1 queen bed and 1 twin bed), with a private bathroom and kitchen attached, and lovely farm views. A second private bedroom (1 queen bed, and a massage chair!) is also available upstairs.
Downstairs you will find a finely furnished living room (with a flatscreen TV, streaming movies, and lots of DVDs). If needed, the living room converts to a third bedroom by closing the doors and opening the sofa into a double bed.
Outside, you and your guests also have access to a large fire pit, a gas grill, and picnic tables.
Guest access
Private front-door entry. Plenty of free parking. Access to our farm and trails. Plus all Amherst has to offer (see the guidebook section of this listing).
Interaction with guests
The farm family lives in the separate adjacent home, and is often available to assist with anything you might need. We welcomes as much or as little interaction as you like. Chat about local sustainable livelihoods, tour the farm and CSA, or enjoy your privacy and do your own thing.
The neighborhood
A walkable/bikeable community, that cares about being a community. Stroll west past Emily Dickinson's homestead on your way to dinner in the center of town. Or turn east toward mother nature and hike to the Amethyst Brook Conservation Area, Mt. Orient, and the Robert Frost trail at the back of our farm.
Getting around
Easy access to the Five Colleges. Bus service (Pioneer Valley Transit Authority) is available on the corner (North East Steet and Main Street).
Other things to note
Historic farmhouses have their charms and quirks.
N.B. There is only one bathroom available, and it is accessed through the master suite bedroom. This is perfect for couples, and usually works well for families and good friends too. Unrelated parties can still be very comfortable by using the other two private bedrooms, and keeping the suite open for kitchen and bathroom access.
EXTRAS: You may also book a horse-drawn WAGON/SLEIGH RIDE or HORSEBACK RIDING LESSONS. Ask for details. Drop-in CSA VEGETABLES shares are also available.
To reduce common allergens we DO NOT PERMIT SMOKING OR PETS in the house. (Although we can probably accommodate your pet in a stable, upon request.)
We also ask that SHOES BE LEFT ON THE PORCH or in the entrance foyer. This has proven to be an prudent policy on a working farm. Thank you!
Cancel up to 5 days before your trip and get a full refund, including service fees.
107 Reviews
An academic (evolutionary biologist) turned sustainable community farmer.


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Car Tires, Maintenance & Repairs Close To 33496
Welcome to Tires Plus Total Car Care, where we have the tires and services you need to get your car or truck back on the road. Get a tire quote online, schedule an appointment, or stop by a nearby 33496-area Tires Plus location.
Tires Plus Locations Near 33496
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At Tires Plus, our goal is complete customer satisfaction. We want to surpass our guests' expectations of a tire and auto service shop. What's more, we think top car care should always be affordable. That's why we have a number of coupons for tires and services. Come in to your 33496-area Tires Plus location or schedule an appointment today!
Services And Deals Offered At Tires Plus
At Tires Plus, the Plus means we strive for excellence. That's why our services aren't limited to tires. Whether you're bringing your car for a routine maintenance check or repair services, you can rely on your local Tires Plus near 33496 for all automotive needs.


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Good day everyone, our newly posted coloring picture which you could use with is Mickey Mouse And Friends Coloring Page, posted in Mickey Mouse category. This below coloring picture dimension is around 600 pixel x 772 pixel with approximate file size for around 80.92 Kilobytes.
To get more picture related to the picture above, you could check the below Related Images segment on the bottom of the site or just surfing by category. You might find many other enjoyable coloring picture to pick up. Enjoy!


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Hats off to Joseph and his colleagues - service at Premier Inn is always reasonably good, but at this Inn, it exceeds expectations. Joseph not only took care of our luggage and held on to it until we returned from our night out, but gave us good advice about trains into London, saving money on parking and just making us feel valued. We also observed Joseph dealing with a very unreasonable customer - he was patient, empathetic and careful - and very impressive. The Inn is new and everything is very comfortable, shiny and clean. Good exemplar for Premier Inn, especially as some of the Inns are looking a little worn.
- Official Description (provided by the hotel):
- Dagenham is a residential suburb in north east London, which lies alongside the River Thames. Conveniently situated in Chequers Corner, close to the A13, linking the M25 with the City of London. Dagenham is famously home to a large Ford Motors car plant, while to the east are both The Chase and Rainham Marshes Nature Reserves and to the west are the Excel Arena and Stratford. Our London Dagenham Premier Inn has all you would expect, incredibly comfy beds in every room and an onsite Brewers Fayre restaurant serving great value pub favourites in a family friendly atmosphere. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Premier Inn so you can book your Premier Inn London Dagenham Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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Convection Oven Cooking Time Chart - Are you looking for information on calculating convection oven cooking times? Find out about calculating convection ...
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text: AP Top Premium Entertainment Headlines At 4:40 p.m. EDT Wonderwall.com Editors The Associated Press 8:40pm PDT, Sep 2, 2012 ShareTweetPinEmail Actor Crowe gets lift after getting lost kayaking ShareTweetPinEmail SpotlightWe Recommend 11 hours ago See the worst (and best!) dressed stars this month 11 hours ago Share Tweet 11 hours ago Ariana Grande is 'broken' after terror attack, Katy Perry wants to settle Taylor Swift feud and more news you might have missed for May 21-26 11 hours ago Share Tweet May. 24, 2017 Selma Blair steps out with some serious bling on on her left ringfinger; did Ron Carlson propose? May. 24, 2017 Share Tweet May. 25, 2017 How Ariana Grande is processing the Manchester attack, plus more news May. 25, 2017 Share Tweet ShareTweetPinEmail


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Today marks the start of my second decade on Twitter. On 7 May 2007, I signed up for the … [Read More...]
Marc Hindley has worked marketing and publicity for more than 25 years in both print and online media.
With experience in advertising, journalism, photography, video and web, both in a news context and for commercial enterprise, he runs a web services agency Canary Dwarf and is a director at Chit Chat PR & Digital.
He was a debut winner of a national social media award in 2009 for his work on a news aggregation platform.


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New York, United States DESCRIPTION ABOUT STAQ: STAQ is a digital media operations system that automates and unifies performance data across the ad technology stack for brand publishers, tech platforms and agencies. Automating the collection of yield & ROI reporting data4/15/2017 New York, NY Save This Job
Associate Product Manager Product Management - Providence, RI - Full Time POSITION SUMMARY: This role is responsible for gathering/defining the business/functional requirements for existing products within the RSi product suite relative to a specific geography, channel,3/29/2017 Providence, RI Save This Job
Req Id 3381 - Posted 05/05/2016 - Corporate Headquarters ? Denver, CO - Technology Operations ? Job Description Print Preview Apply Apply using LinkedIn? Save Job Email Job to Friend Return to List Summary We believe feeling good and doing good is the best reward,2/9/2017 Denver, CO Save This Job
Req Id 4501 - Posted 01/20/2017 - Corporate Headquarters - Denver, CO - Operations ? Job Description Print Preview Apply Apply using LinkedIn? Save Job Email Job to Friend Return to List We believe feeling good and doing good is the best reward, which is why our motto2/9/2017 Denver, CO Save This Job
United States - Houston ? Job ID 1934 Job Summary The Customer Success Manager will champion the customer throughout the engagement lifecycle, enabling them to get best value from Alert Logic solutions. Further, this role is expected to establish themselves internally with the5/18/2017 Houston, TX Save This Job
United States - Austin ? Job ID 1954 Job Summary The Customer Success Manager will champion the customer throughout the engagement lifecycle, enabling them to get best value from Alert Logic solutions. Further, this role is expected to establish themselves internally with the5/18/2017 Austin, TN Save This Job
Zend is growing rapidly in North America and recruiting for Senior Enterprise Account Manager. This role is responsible for generating new business across North America within Fortune 1000 companies and upper tier SMB. Working directly with the Worldwide VP of Sales, the4/23/2017 Austin, TX Save This Job
Bus Dev/Partner Svcs Apply now Posted: 17 March 2017 Full-time Atlanta, GA, United States The Strategic Account Marketing Manager is a critical role and thought leader in the Energy Solutions team. As a Strategic Account Marketing Manager, you will be responsible for4/22/2017 Atlanta, GA Save This Job
The Account Manager is responsible for helping to maintain long term business relationships with partner health systems by effectively managing projects and services, and providing outstanding customer service to our clients and business partners. The Account Manager reports to4/17/2017 Seattle, WA Save This Job
As the Interconnection Product Manager, you?ll define and execute the networking and interconnection strategy supporting all of Peak 10?s colocation, cloud, and managed services. This position is a key member of the product management team and will have the unique opportunity to4/8/2017 Charlotte, NC Save This Job
Product Management - Mountain View, CA - Full Time POSITION SUMMARY: This role is responsible for defining the roadmap and business/functional requirements for the key products within the RSi product suite. The Product Manager acts as a liaison between the business stakeholders3/29/2017 Mountain View, CA Save This Job
United States - Houston ? Job ID 1952 Job Summary We are continuing to expand our team and are looking for a Senior Product Manager, Incident System to join some of the industry?s brightest minds that are dedicated to providing our customers and partners with security value and5/18/2017 Houston, TX Save This Job
NEW YORK, NYOPERATIONSFULL-TIME APPLY FOR THIS JOB Want to help disrupt the education industry? Looking to have a direct impact on a company?s bottom line while partnering with almost every team? Work at Knewton as our Operations Associate. Reporting to the Manager of5/12/2017 New York, NY Save This Job
REPORTS TO: CEO LOCATION: White Plains, NY DEPARTMENT: Administration PREPARED: April 18, 2017 POSITION SUMMARY: Reporting directly to the CEO, this newly created position will fill a critical role in which an experienced healthcare sales manager will plan, coordinate and lead a5/8/2017 White Plains, NY Save This Job
JOB DESCRIPTION The Product Manager, AV is the single point of accountability for managing relationships and coordinating installation with external hardware, software and service providers. In this role, Project Manager, AV will evaluate and confirm key vendors, support4/27/2017 Addison, TX Save This Job
Prolacta Bioscience Inc. ? Duarte, CA Posted 29 days ago Apply Now Email Job Save Job Job Snapshot Full-Time Experience - At least 1 year(s) Degree - 4 Year Degree Biotechnology Marketing Relocation - No 21 Applicants How Do You Compare to the Competition? Get facts4/27/2017 Duarte, CA Save This Job
at Tremor Video (View all jobs) New York, NY PUBLISHER ACCOUNT MANAGER The Publisher Account Manager is expected to provide first in class service and operations support to their portfolio of publisher partners that rely on Tremor Video?s best in class Video SSP. They will be4/23/2017 New York, NY Save This Job
Location: Corporate Office - Leesburg, VA Full Time Requisition Number: req373 Summary: The Contract Manager for the Pricing and Contracts Department works in a fast paced, team oriented environment that partners closely with other internal departments to provide optimum4/19/2017 Leesburg, VA Save This Job
Location: Corporate Office - Leesburg, VA Full Time Requisition Number: req407 Summary: Supports the Product Manager/Marketing VP in implementing growth plans for product lines. Assists with product development, collateral material development, catalog development, and trade4/19/2017 Leesburg, VA Save This Job
Location: Remote The Client Services Manager (CSM) at InDemand Interpreting is responsible for providing exceptional account management and support for their assigned healthcare organizations. The CSM manages the relationship from implementation, throughout the life of the4/16/2017 Lombard, UT Save This Job


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Raita recipes such as onion Raita recipe make your meal more colorful as well as healthier. It contains all the goodness of fresh onions and yogurt.
You can use Homemade Yogurt
or store bought yogurt for this.
This Indian salad recipe is a side dish that is served with a variety of Indian rice or roti bread. Not only it is a very healthy recipe, but it is easy and simple and quick salad recipe too.
It would take you just a few minutes (the time to chop onions). about 5 minutes total including the tempering to make this raita.
You may use red onions or white onions for raitha. Tempering is optional.
Ingredients for tempering
Preparation -
Prepare tempering -
Final Mixing
You can add black pepper powder along with or instead of green chili according to your taste.
The plain yogurt(curds)should be fresh and sweet. Make sure it is not sour.
Add 1 tbsp fresh grated coconut to this raita if you wish.
Keep the raitha in the fridge if you are planning to serve it later. If left outside, it can get sour.
Raita tastes wonderful with all the rice dishes as well as roti breads.
Related Pages to visit:
How to make yogurt at home - Homemade Yogurt.
Go to Raita Recipes Page From onion Raita recipe
Go to Vegetarian Recipes Home Page from onion raita
May 20, 17 01:37 AM
Easy mango pickle recipe for an indian pickle, a raw mango recipe
May 16, 17 03:58 AM
Pressure cooker recipes are faster cooking compared to cooking the same recipe on the stove top
May 11, 17 12:37 AM
Phodnichi poli leftover chapati recipe. Policha kuskara is a Maharashtrian leftover chapati recipe


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backroomnoun [ C ]uk /ˌbækˈruːm/ /ˌbækˈrʊm/ us /ˌbækˈruːm/ /ˌbækˈrʊm/
› a room in which work or other activities are done out of public view or secretly:
backroom staff
backroom negotiations
Thesaurus: synonyms and related words
(Definition of "backroom" from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)
(Definition of "backroom" from the Cambridge Business English Dictionary © Cambridge University Press)
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More meanings of "backroom"
Word of the Day
a coloured substance, usually contained in a pencil, that is put in a line just above or below the eyes in order to make them look more attractive


text:
A couple of WEC veterans will look to make a big impression this weekend as XFO hits Chicago's Sears Centre on May 13.
Former WEC featherweight turned bantamweight Jeff Curran will lead the card, but he is heading back to 145lbs after his initial opponent Joe Pearson was knocked off the show after being involved in an automobile accident.
Curran will now face replacement fighter Billy Vaughan, who has a habit of stepping up on short notice lately. Vaughan took a fight with Jorge Gurgel in Strikeforce on short notice back in March, but ended up being submitted by the Brazilian Jiu-Jitsu black belt in less than a minute.
Vaughan will take on Curran in the main event now taking place at featherweight, with Curran coming back from elbow surgery that has kept him out for the past several months. Now healthy, Curran is determined to make his way to the UFC's bantamweight division and he hopes the next step will happen at XFO this weekend.
Curran was actually scheduled to be out of action until mid-2011, but recovery went better than expected and after almost being a one-armed fighter for the last few years, he's excited to see what he can do now.
"I never really thought that my arm played that much of a role, but now that I see the habits that I developed training and protecting it, less sparring because of the pain, and all that, not having training partners throw head kicks on that side, and it was a little bit of a bump in the road to slow me down," Curran told MMAWeekly.com.
Also on the card will be former WEC lightweight champion Jamie Varner, as he makes his first appearance in his post-Zuffa career. Varner ended his time in the WEC going 0-3-1 over his last 4 fights, and was released from the promotion following a loss to Shane Roller at WEC 53 last December.
Much like Curran, Varner is looking to make an impression in his fight at XFO to start the road back to hopefully get another shot in the UFC. Varner will take on Tyler Combs in a catchweight bout of 165lbs on the card.
Varner is still in talks to possibly take a fight with Shinya Aoki in Japan later this month, but for now he'll concentrate on facing Combs in Chicago.
Funny enough, Tyler Combs also has a connection to the Strikeforce card that took place in Ohio in March as he was the original opponent for Jorge Gurgel on the show, but droppd out at the last minute with a training injury.
The women will take the main stage at XFO as well with both Felice Herrig and Michele Gutierrez appearing on the show.
Herrig and Gutierrez are set to appear in the upcoming MMA video game 'Supremacy MMA' but will first look to face the competition in Chicago this weekend.
Herrig will face Nicdali Calanoc, who is a veteran of both Freestyle Cage Fighting and Hook 'N' Shoot, while Gutierrez takes on Amanda LaVoy.
The card will feature 12 bouts in all with the action starting at 7pm CT in Chicago.
Marlon Moraes is headed to the UFC, but faced former WEC world champion Miguel Torres at the inaugural WSOF1 on November 3, 2012, in Las Vegas. read news >>
Based on a couple of Instagram posts these past few weeks, UFC Hall of Famer Chuck Liddell looks like someone in search of a fight. And people have noticed. Here was Liddell throwing some serious elb read news >>
Tyron Woodley is training for a fight but still has no opponent, although he's called out a few.Filed under: Featured, News, UFC read news >>
Former UFC bantamweight champion Dominick Cruz wants to fight the winner of Cody Garbrandt and TJ Dillashaw, and believes that he's earned the right to do so. read news >>
Chuck Liddell quit fighting nearly seven years ago, but don't ever say never on a comeback. read news >>
Just $50 will get you in the arena for the UFC's first Oklahoma City event in eight years, and not much more than will get you right next to the octagon.Filed under: News, UFC read news >>
LAS VEGAS – UFC heavyweight contender Francis Ngannou doesn't have a fight lined up. First thing's first – he needs to get acclimated.Filed under: Featured, Featured Videos, News, UFC, Videos read news >>
Set to face Sheila Padilla at Friday's Combate Americas, atomweight Alyssa Garcia looks back on her career-changing Rizin FF 3 win over Kanna Asakura and the feeling that 'If I can do this, I can do read news >>
Interested in seeing two fighters meet in the UFC? Tweet them. You never know what might happen.Filed under: News, UFC read news >>
As Conor McGregor previously announced, his SBG Ireland teammate will compete at UFC Fight Night 113 in Scotland.Filed under: News, UFC read news >>


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Went to M.Beach for ladies weekend. Came here one night for some drinks. Loved the outside atmosphere with the seating and band playing. Drinks and service were good. Would love to come back to see Darius play here!
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Rapid response
December 26, 2012
We would like to thank the Ophir Fire Department for their quick response to our garage fire. What a great group of guys.
Thank you again.
Jerry and Jackie White
Grass Valley
Trending In: Letters
Trending Sitewide
- Vehicle crashes into Grass Valley hair salon (VIDEO)
- Nevada County Police Blotter: Caller reports transients 'humping' in public
- Nevada County donor pledges to match contributions to Hospitality House
- Man dies from NorCal gas station nacho-cheese dip
- Downtown Grass Valley police chase ends in creek, police say


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9 February 2017, Brussels
Synergies between Horizon 2020 and the European Structural & Investment Funds (ESIF) could support the uptake of pilot lines and their services and boost regional investments and new business.
Over 80 people gathered in Brussels February 9, 2017, to share experience, work collaboratively, and discuss the state of play and future developments of the pilot lines for upscaling nanotechnologies and advanced materials for regional growth.
Regional representatives of different Members States, together with Project Coordinators, exploitation leaders, pilot line developers from RTOs, businesses, and civil society organisations actively joined the discussion, and interesting lessons came up from good practices for future widening initiatives across Europe.
This workshop gave the participants the opportunity to be actively engaged in the process of collecting ideas for future activities and priorities for the 2018-2020 programming period. The high turn up and active engagement of invited experts in the discussion marked the success of this initiative launched and organised by DG Research in close collaboration with DG Regio, GROW, and JRC.
Participants unanimously called for another meeting, in 6 months from now, to make the point of what suggested and plan ahead. A summary of the workshop highlights will be made available shortly.
For additional information, please contact firstname.lastname@example.com
Related documentation
ThemesEC-organised event | Horizon 2020 | Key Enabling Technologies | Nanosciences, nanotechnologies | New materials and new production technologies


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text:
A day at the Balcormo Races - another successful Fife point to point meeting
Ledingham Chalmers partner Jim Drysdale gives his report on last weekend's Balcormo Races, held in Fife.
Ledingham Chalmers partner Jim Drysdale gives his report on last weekend's Balcormo Races, held in Fife.
Proper planning, together with professional legal and financial support can ensure a smooth transition into the farm business for the next generation.
Retiring partner Allan Collie explains the importance of events such as the Young Farmers Overwintered Cattle show and sale to the farming sector.
This year's record-breaking Royal Northern Spring Show was a fitting send off for partner Allan Collie, who's retiring at the end of March.
Succession planning in family farming businesses can be a challenge, but not facing up to that can bring unintended results when it's too late.
Leadership and the importance of finding your purpose - What does it take to rightfully earn the reputation of a great leader? Firm chairman, Jennifer Young, reports from the world's largest one-d...


text:
Written on: 13/05/2013
So this is my first time ordering from ASOS and so far I love it! I ordered seven things and it took exactly one week to arrive. Their tracking service was great and told me where my package was at all time whereas I ordered from a few other places and their tracking stopped and my packages came randomly. The clothes were great and I would order from this site again!
Written on: 14/05/2013
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Wimbledon Jobs
Found 28 jobs in this campaign
RelevanceNewest first
Travel Consultant - Wimbledon
Multi-award-winning travel company, Flight Centre, has an exceptional opportunity for a travel consultant or sales professional to join us.
Nursery Teacher - Wimbledon
A unique opportunity has arisen to join an expanding school in the South West London borough of Wandsworth. The school are currently looking to tak...
Assistant Accountant
An enthusiastic bookkeeper/accountant is sought to take responsibility for purchase/sale ledgers, credit control, bank and month-end processes.
Policy Officer (Politics, Government) BLUP49067
Policy Officer (Politics, Government) BLUP49067 Salary; £28,000 Wimbledon, South West London They are looking for an experienced policy officer to ...
Accounts Team Manager (Accountancy, AAT, ACCA, CIMA) BLUA49298
Accounts Team Manager (Accountancy, AAT, ACCA, CIMA) BLUA49298 Wimbledon Salary up to £35,000 Who they are Our client is a leading national charity...
Senior Commercial Lawyer
We are looking for an experienced, fully qualified lawyer, with a strong background gained in both private practice and in-house environments.
Account Manager, B2B Tech PR
B2B Tech Account Manager/Senior Account Executive up to £35k, Wimbledon based.
Secondary Teacher after 2 years training. Merton School
Be a Teaching Assistant for 2 years, train and become a qualified teacher within 2 years
Head of English
Head of English – Merton, South London – perfect opportunity for a current Head of English or experienced English Teacher – September 2017 start
Nursery Class Teacher - Wimbledon
An popular 'Outstanding' primary school based in the London Borough of Merton is seeking to appoint a full time Early Years Foundation Stage (EYFS)...
Nursery Class Teacher - Wimbledon
An popular 'Outstanding' primary school based in the London Borough of Merton is seeking to appoint a full time Early Years Foundation Stage (EYFS)...
Trainee Recruitment Consultant - Resourcer
Trainee Recruitment Consultant. Finance, Technology, Maths, Science degrees preferred. Fluent in English, German, Dutch, Scandinavian Languages.
Wimbledon - Key Stage 2 Teacher & Phase Leader
* Key Stage 2 (KS2), Year 3* TLR* Inner London pay weighting ( + TLR)* Fantastic location, close to underground linksThis 'good' school in the Lon...
Junior School Music Administrator (part-time)
We are seeking to appoint an administrator to assist the Head of Music in the Junior School on a part-time basis. Applicants will need strong inte...
Merton Arts Space Manager
The Library Service is seeking to recruit an experienced cultural events and programme manager
Dean of Design
As Dean, you will provide the academic leadership of the Design discipline.
Dean of Arts
As Dean, you will provide the academic leadership of the Arts discipline.
Dean of Academic Development and Student Communities
The Dean of Academic Development and Student Communities will be an exceptional leader with a record of co-ordinating interdisciplinary innovations.
SEN Teacher
SEN Teacher - MSI Key Stage 1/2 London Borough of Wandsworth Good-Outstanding School Long Term Contract Starting either Immediately or from September
Business Studies Teacher
Business Studies Teacher – Business NQT – Merton, South London – Ideal for a NQT or experienced Business Studies Teacher – September 2017 start


text:
Another Sky On Fire
Several years ago, in the late summer and fall of 2008 and 2009, I saw some of the most breathtaking sunsets I've ever seen to date. This is of one of those sunsets, taken from our living room window.
312 views
14 faves
31 comments
Taken on September 25, 2009


text:
uploaded 1 year ago
Cipelica stiklica - intro. Animation.
Folder: Videos - Animations
Uploaded: Sep 26, 2015
Views: 372
Likes: 36
Tags: Cipelica stiklica, Intro, Stikla, Pink, Glass, Logo, Animation
i want lick
by gizwiz
Rose petal Jam
by Borislav-Aleksiev
Collection of old buttons
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by stksksss


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There was an error with my reservation but the wonderful staff worked it out with me. Due to the error I was unable to get a non-smoking room but room was so clean I couldn't tell.
Exceptional service,
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fabulous pet policy
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text: Posted June 30, 2003 I just wanted to let anybody fishing or boating on the river South of Little Falls to be extra careful. While on the river Sunday afternoon We expierienced lots of floating debris, from branches to logs in excess of 20' Just a friendly reminder. Safe boating! Share this post Link to post Share on other sites


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The Vuvuzela
2.13pm Friday 11th June 2010
Members of our news team take a look at the must have World Cup item, the Vuvuzela.
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