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Using high-throughput sequencing, investigators make a surprising discovery about the immune system.
As elite soldiers of the body's immune response, B cells serve as a vast standing army ready to recognize and destroy invading antigens, including infections and cancer cells. To do so, each new B cell comes equipped with its own highly specialized weapon, a unique antibody protein that selectively binds to specific parts of the antigen. The key to this specialization is the antigen-binding region that tailors each B cell to a particular antigen, determining whether B cells survive boot camp and are selected for maturation and survival, or wash out and die.
Now, using high-throughput sequencing technology and computational and systems biology, investigators from Beth Israel Deaconess Medical Center (BIDMC) have discovered that B cells can be selected for survival independent of their antigen binding regions. Described online this week in the journal Proceedings of the National Academy of Sciences (PNAS), the findings add a surprising new dimension to the understanding of antibody repertoires – each individual's complement of millions of B cells -- and the potential for shaping these repertoires to better fight disease.
"B cells play essential roles in vaccination, infection, autoimmunity, aging and cancer," explains senior author Ramy Arnaout, MD, DPhil, an investigator in the Department of Pathology at BIDMC and Assistant Professor of Pathology at Harvard Medical School whose work focuses on the emerging field of high-throughput multimodality immunology, also known as immunomics. "We were surprised and excited to find that B cell survival could be influenced by a non-antigen-binding region of the antibody, specifically the 'elbow' region that connects the antigen-binding regions to the signaling domain."
Each new B cell makes its own unique antibody by mixing and matching from a set of a few hundred genes, taking one each from subsets called V, D and J. The most diverse part of an antibody is the region where the three genes come together, a stretch called the third complementarity-determining region, or CDR3.
"CDR3 is thought to be the single most important determinant of antigen binding," explains Arnaout. As a result, in understanding how the body fights infections and in developing new vaccines, immunologists have primarily focused their attention on CDR3, while considering other parts of the antibody, including the elbow region, to play secondary roles.
In their new study, Arnaout and colleagues sequenced 2.8 million VDJ-recombined heavy-chain genes from immature and mature B-cell subsets in mice. "We initially wanted to ask how selection on CDR3 changed antibody repertoires during B-cell maturation," says Arnaout. But, unexpectedly, during the course of the investigation, they found they were instead focused on the antibody's 'elbow' region."
They found that B cells for which antibodies use V genes that encode 'looser' elbows were more likely to mature, regardless of their CDR3 sequence. This effect was both distinct from, and larger than previously described maturation-associated changes in CDR3 in the mice. Furthermore, it had a unique source: Differences in the V genes were hard-coded into the genome, as opposed to the mixed-and-matched combination of V, D and J genes that typically differs from B cell to B cell.
"This discovery was a little like going to watch a concert pianist perform and being mesmerized by her fingers only to realize that music was also coming from her elbows," says Arnaout. "It was something of a shock."
One explanation for how this "loose elbow" promotes survival relates to the bending process of the antibody. "B-cell selection and maturation depend on signaling," he explains. "Antigen binding is the signal, but for it to get to the cell it has to go through the elbow. It, therefore, makes sense that previous experiments have found that disrupting the elbow abolishes signaling without affecting antigen binding. We think a loose elbow might affect how the cell perceives binding, which then determines whether the B-cell soldiers are able to divide and form an elite antigen-fighting platoon, or turn in their weapons and retreat."
Ultimately, the authors write, "This discovery adds a surprising new dimension to the understanding of antibody repertoires and might one day help us shape them ourselves."
Coauthors include BIDMC investigators Joseph Kaplinsky (first author) and Anthony Li and New York University Medical Center investigators Amy Sun, Maryaline Coffre and Sergei B. Koralov (co-senior author.) Coffre and Koralov were supported by a grant from the Beckman Foundation.
Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School, and currently ranks third in National Institutes of Health funding among independent hospitals nationwide.
The BIDMC health care team includes Beth Israel Deaconess Hospital-Milton, Beth Israel Deaconess Hospital-Needham, Beth Israel Deaconess Hospital-Plymouth, Anna Jaques Hospital, Cambridge Health Alliance, Lawrence General Hospital, Signature Health Care, Commonwealth Hematology-Oncology, Beth Israel Deaconess HealthCare, Community Care Alliance, and Atrius Health. BIDMC is also clinically affiliated with the Joslin Diabetes Center and Hebrew Senior Life and is a research partner of Dana-Farber/Harvard Cancer Center. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.org.
Bonnie Prescott | newswise
Discovery of a Key Regulatory Gene in Cardiac Valve Formation
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as 'sluggish'. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June
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Measured for the first time: Direction of light waves changed by quantum effect
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Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June
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subset: commoncrawl


text:
YP - The Real Yellow PagesSM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you might use to determine which business to select from a local Yellow Pages directory, including proximity to where you are searching, expertise in the specific services or products you need, and comprehensive business information to help evaluate a business's suitability for you. "Preferred" listings, or those with featured website buttons, indicate YP advertisers who directly provide information about their businesses to help consumers make more informed buying decisions. YP advertisers receive higher placement in the default ordering of search results and may appear in sponsored listings on the top, side, or bottom of the search results page.
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Four Libyan soldiers were injured in clashes with forces of the Shura Council of Benghazi Revolutionaries on Thursday.
In exclusive statements to MENA, Galaa Hospital spokeswoman Fadia al Borghothi said the hospital received four soldiers of the Libyan army who were injured in clashes in the past two days.
Two soldiers were discharged, while two others are still receiving treatment, she added.
Source: MENA
GMT 08:32 2017 Friday ,19 MayINTERVIEW - Libya: The battle for dignity
GMT 20:51 2017 Tuesday ,16 MayTripoli University undersecretary kidnapped, exams delayed
GMT 20:59 2017 Sunday ,14 MaySecurity checkpoints deployed in Tripoli
GMT 20:46 2017 Saturday ,13 May3 explosions hit Libyan capital
GMT 07:37 2017 Saturday ,13 MayWay forward for Libya uncertain despite 'breakthrough' meeting
GMT 15:33 2017 Thursday ,11 MayICC prosecutor mulls inquiry on crimes against migrants in Libya
GMT 20:48 2017 Thursday ,04 MayCasualties of missile attacks in Benghazi
GMT 22:05 2017 Wednesday ,03 May49 army personnel killed during April clashes in Benghazi


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I love paper-crafting!
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A hilarious, informative guide to language and grammar inspired by America s favorite maverick….
Tag Archives: Learn
Learn to Program with Python
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Prominent Saudi businessman Saleh Kamel has estimated the total value of Zakat in the Kingdom at SR 1 trillion, and said such a huge amount could be used to solve many economic and social problems in the country. Kamel, who is also chairman of the Islamic Chamber of Commerce and Industry, said people should pay Zakat for real estate properties that have been for sale. "We Muslims should understand the economic wisdom behind the Zakat system. If we collect and use Zakat properly, it can bring about substantial improvement in our economic condition," Kamel told a gathering of businessmen and academics in Madinah. He added: "If we had collected Zakat from real estate properties we would not have faced the housing or land problems." Kamel emphasized the need to introduce purely Islamic products for promoting Islamic banking and finance. Referring to the global economic crisis, he said it would not have taken place if the world had implemented a small Hadith of the Prophet (peace be upon him), which says: "Don't sell what you don't possess." Kamel said he had discussed this matter with German Chancellor Angela Merkel. "I can tell you that Islamic economics offers solutions for world problems. We have to understand the system and implement it properly." The Saudi businessman said Zakat could also solve unemployment problem faced by many countries. "If we introduce modern financial methods, Zakat can be used for the poor to participate in productive means," he said. He emphasized the need to introduce innovative Zakat-based programs to improve the condition of poor families. From: Arabnews
GMT 16:56 2017 Wednesday ,24 MayMoody's cuts China's rating on debt concerns
GMT 04:00 2017 Wednesday ,24 MayChina further opens energy sector to private investment
GMT 03:45 2017 Wednesday ,24 MayHedge funds shuffle positions as OPEC decision nears
GMT 03:28 2017 Wednesday ,24 MayOPEC set to prolong oil cuts as delegates predict smooth meeting
GMT 18:28 2017 Tuesday ,23 MayGreece Fails to Secure Fresh Bailout Funds
GMT 18:10 2017 Tuesday ,23 MayIMF demands more from eurozone on Greek debt relief
GMT 05:19 2017 Tuesday ,23 MayDisrupt or die? No chance: Experts say e-commerce, will not collapse luxury industry
GMT 05:06 2017 Monday ,22 MayBoosting human resources as important as investment deals


text:
As part of my senior study project and final year at Goddard College, I wanted to learn more about reparations movements. My adviser encouraged me to read the books that I have written about in this annotated bibliography, which I wrote with an intention to share out some of the content that I highlighted in my reading of each of these books. The books that I have included in the annotated bibliography are:
Robinson, R. (2001). The debt: what America owes to Blacks. New York: Plume.
Anderson, C. (1994). Black labor, white wealth: the search for power and economic justice. Edgewood, MD: Duncan & Duncan.
Rodney, W., Strickland, W., Hill, R. A., Harding, V., & Babu, A. R. (2011). How Europe underdeveloped Africa. Baltimore, MD: Black Classic Press.


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7 Mar 2009 ... Zebrahead - Check. ... Tony Hawk's Pro Skater 3 OST - Check .... when you find out the lyrics you wanna sing it but you can't remeber it all XP.
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Tony Hawk's Pro Skater 3 is a skateboarding video game in the Tony Hawk's series. ... These were variations on standard tricks that could be performed as grab, flip, lip, or grind tricks. For example, double-tapping the kickflip button wou
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Tony Hawk´s Pro Skater 3 (Abk. "THPS3", oft einfach nur Tony Hawk 3) ist ein Videospiel der ... Boy Who Destroyed The World; Reverend Horton Heat – I Can't Surf; Adolescents – Amoeba; CKY – 96 Quite Bitter Beings; Zebrahead – Check ...
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2011 CHEVROLET Aveo LT Sedan 4D
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Epson R1800 off-center printing issue
Started Nov 12, 2007 | Discussions thread
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Mr Bjarner • Regular Member • Posts: 225
Re: Epson R1800 off-center printing issue
In reply to PatrickNSF • Nov 12, 2007
Congratulation on your new printer. The off center issue is quite knows on the epson printers. A solution that have worked for me on the 3800 is to setup custom paper sizes of the exact same sizes, as you would pick using the canned sizes. Hope this helps you as well.
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4346 Cochran Chapel Cir Dallas, TX 75209(Bluffview)
- 3 beds
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Home Details for 4346 Cochran Chapel Cir
Information last updated on 05/11/2017 12:00 AM:
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Official property, sales, and tax information from county (public) records:
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Episode 558 of 759 episodes
Rooney and Mourinho take on Leicester this weekend but how well equipped are Manchester United to take on the Champions? We'll hear from Kevin Nolan on how players can improve their chances of succeeding as managers and look at how Arsene Wenger could beat Chelsea.
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County School notes: Highland girls have sights set higher
January 30, 2014
Free throws
» Navy bound: In case you missed it in Monday's Tribune, Windsor's 6-foot-3, 320-pound senior center Trenton "Tiny" Noller verbally committed Sunday to play football for Navy.
Noller made the commitment during an official visit this past weekend to the United State Naval Academy in Annapolis, Md.
Noller also received offers from Georgia Tech, Arizona, New Mexico State, Wyoming and the University of Northern Colorado.
National Signing Day is Feb. 5.
» Weld's elite: A slew of wrestlers are ranked fourth or higher in the latest statewide On the Mat wrestling rankings.
Highland has three top 4 wrestlers in 2A: Jakeob Trujillo (2nd, 120), Sean Belfrage (4th, 182) and Theo Zimmer (4th, 195).
There are 10 wrestlers from three different Weld schools cracking the top 4 in 3A: Valley's Zac Damian (4th, 113), Ruben Lucero (2nd, 126), Omar Sotello (3rd, 138), Zac Miller (2nd, 152), Brendan Gonzales (1st, 160) and Jackson Wright (1st, 170); Fort Lupton's Jody Sandoval (4th, 106), DJ Vurciaga (1st, 182) and Jacob Ornelas (2nd, 220); Eaton's Michael Cardona (3rd, 160).
In 4A, Windsor has five top 4 wrestlers: Josh Villa (2nd, 113), Jonathan Lewis (1st, 120), Matteo Ambriz (4th, 126), Kennen Lanteri (1st, 152) and Joseph Keller (4th, 170). Weld Central has one, defending state champion Dalton Robertson (1st, 126).
Valley is second in the 3A team rankings — behind Brush — while Fort Lupton is seventh.
Windsor is fourth in the 4A team rankings.
Good enough isn't really good enough anymore for the Highland girls basketball team.
In fact, after years of struggling in the sandpaper gritty Class 3A Patriot League, merely being respected within the league isn't really all that respectable if you're wearing Huskies green and gold.
For Highland (1-2 Patriot, 6-6 overall), the objective is to win — and win big — despite being a 2A team playing in a league made up primarily of some of the toughest competition in 3A.
With that said, one could hardly blame Huskies players for not exactly doing cartwheels and dropping confetti after their 47-43 loss to Platte Valley (3-1, 10-3) on Friday, despite pushing to the limit one of the best teams in the league — and perhaps the state.
"We come out, step on the floor and expect to win," said Highland coach Steve Latuda, who is in his second stint coaching the Huskies. "We don't look at names. We don't look at who's who. We just come out, we battle our butts off and play as hard as we can. We don't back down."
After a challenging nonleague slate made up mostly of top teams in 2A, Highland had little trouble with Lyons in their league opener, winning 49-28 on Jan. 14.
A week later, the Huskies faltered on the road against league favorite Sterling, losing 55-41.
After its loss last week to Platte Valley, Highland will have a chance to get back to .500 in league against a quality Strasburg squad (3-1, 11-2) at 7 tonight in Ault.
A year ago, the Huskies (13-11 overall) preceded a run in the 2A postseason with a 3-7 record in league, good enough for eighth in the 11-team league.
Like this year, Highland began league play last winter with a dominant win against Lyons before losing by double-digits to Sterling.
However, this year, the Huskies played the Broncos much tougher after losing 52-39 last winter to a Platte Valley team that didn't quite match the experience and poise of this year's Broncos.
Highland junior Jamie Clawson (16.4 points, 10.4 rebounds per game) is the team's on-court leader and arguably the best all-around athlete walking the halls of Highland High School.
Clawson and her teammates have made a point to step up their game this year with an eye on being a player in the Patriot League before perhaps being a contender in the 2A playoffs.
"A few years ago, (opponents) would have been like, 'Oh, you guys are playing Highland, go beat them by 50,' " Clawson said. "But, now it's like, 'Oh, you're playing Highland. You better bring your A-game.' "
Bobby Fernandez covers county schools sports and is the sports editor for The Tribune. Reach him at (970) 392-4478, by email at firstname.lastname@example.com or on Twitter @BobbyDFernandez.
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Ken Zell, 70-years old, took first place this weekend in his age group at the 70.3 Ironman in St. George Utah.
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I like to build a workout that resembles race day. The first few hundred yards you're really going after it, then you need to settle in and finish strong.
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Main Set - (1900) 4 x 200 (push the first 50 to just below your sprint speed, then practice slowing it down for the remaining 150 but holding steady on the pace) (30 sec rest in between each) If you are finding that you're slowing down continually during this phase, then slow ...
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When you feel powerful, you are willing to stand up for your rights, you are willing to stand up for what you believe in, you're more willing to stand up and be counted.
It may be no surprise that Pittsburgh has direct flights to London, Paris and Frankfurt, but consider this: many of the tourists here have come from Europe to the capital of culture in the Alleghenies.
Children do have the potential to kill art. But now I think they kill the bad art. At least that is what my son has done for me.
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Home » Multimedia » Photo Galleries » Staff
Atwood Apple Dumpling Festival
Sat, 08/18/2007 - 7:41pm | The News-Gazette
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Monday, May 22, 2017 83 Today's Paper
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Erie's Whole Foods Co-op is the kind of place where you run into all kinds of people – and there, that's cool.
In fact, the Co-op (which, like the sign outside says, has been "Community Owned Since 1978") is quite a lot more than just a fine spot to shop for natural foods and other holistically-minded products; or to take in some very worthwhile community programming; or to eat some really good grub at the Co-op Cafe & Bakery.
Beyond all that, it's the sort of place that, in the lingo of community-builders and forward-thinkers, has even tended to become that heralded "third place": a home away from home (or work), if you will, for many people in and around Erie.
To illustrate just a bit: In the span of 15 minutes or so during our last visit, I had the pleasure of crossing paths with a longtime former pizza industry colleague and his wife; an old hearty-partying cohort (also former, and sort of longtime); and a local crystal enthusiast/Reiki practitioner whose work I'd recently gotten to know.
In that same time, my three-year-old made at least a couple of new fans/buddies herself by belting out her latest iteration of "Yellow Submarine" in the store's bulk herbs section, and we ended up small-chatting with at least a couple of people we'd never met before. All in all, the air around the entire place was nothing if not friendly.
And those few little pleasantry-filled moments met at least a few of celebrated American urban sociologist Ray Oldenburg's published criteria for "third places": a term Oldenburg coined in his influential 1989 work The Great Good Place.
In any true-blue third place, "Conversation is [a] main activity," states Oldenburg: Check.
"The mood is playful": Check.
Regulars. Food and drink. People from lots of walks of life. Check. Check. Check.
"It's somewhat of a community hub for many people," says Co-op General Manager Care Kerlin. "We like to know who our customers are. We care about them. We want to provide not just a pleasant shopping experience, but a pleasant overall experience."
She means that, too. It's actually part of the Co-op's stated mission: "To serve [its] community as the foremost provider of foods and products that enrich health and well-being, while cultivating a spirit of community through excellent service and education."
But meeting that lofty mark means being much more than just a good place to run into friends, acquaintances, and chummy random strangers for a bit of small talk. It even means more than making good use of the Co-op's Community Center, which, since being launched in 2012, has become one of the city's nerve centers for gatherings, workshops, and classes on everything from baking and gardening to meditation and yoga.
When it comes down to it, it also means being a full service natural foods grocery store, and at the Co-op, that designation takes on meaning well beyond the typical mega-store's usually-tiny "organic" and "local" sections.
Along with carrying a bevy of national brand food and health care items, the Co-op aims to be hyper-local in its approach to product sourcing. In-season fresh produce comes from many nearby farms (Sligo-based Clarion River Organics, Hartstown's Weeping Willow Farms, and Tionesta's Edible Earth Farms are just a few). And local eggs, cheese, meats, honey, and handmade body care products additionally occupy space on the Co-op's shelves.
Beyond that, the Co-op further works with local farmers by serving as a designated Community Supported Agriculture (CSA) drop-off spot, providing different farms' shareholders with an easily-accessible, centralized spot to pick up their deliveries of fresh-off-the-farm foods.
And speaking of shareholders, the Co-op is owned not by a corporation, but by the people – local, real, actual people – who are its member-owners, and member-ownership is open to anybody and everybody who's interested in taking part. That said, Kerlin and others at the Co-op are quick to point out that, despite a somewhat common misperception, membership/ownership is not a prerequisite for shopping at the Co-op.
"Everyone is welcome to come here, anytime, to shop," says Kerlin.
If you've never taken the Co-op up on that invitation, give it a try. You'll most likely find some things you'll like – and you may get to feeling third-place-comfortable fast.
To learn more about the Erie Whole Foods Co-op, the products it carries, and all the cool stuff that happens there, stop in to the store at 1341 W. 26th St.; call 456.0282; or visit wfcerie.coop.
Ryan Smith can be reached at email@example.com, and you can follow him on Twitter @ryanmsmithplens.
Your guide to the 2017 festival scene
Analysis, commentary on Erie's latest elections
Frank advice from a former mayor to a future one
Erie team ends its championship drought
Link's work fits the space, where sound just carries well, and, with those barn doors wide open, lingers sweetly as it flows out into the air.
Can you imagine playing poker while paddling through Presque Isle?
Scenic speed bumps and ski mask surprise


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next time!!!!
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This couple belongs on my board too because of real love!Eternally Beautifully Black
:) :)
I love You with my soul because my soul never stops or ..forgets. ~ Rumi


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Chester Bennington: Slipknot's Corey Taylor Approves of 'Great' New Linkin Park Song 'Heavy'
Corey Taylor has repeatedly bashed pop music in the past, but has given Linkin Park's new song 'Heavy' a nod of approval.
Corey Taylor has repeatedly bashed pop music in the past, but has given Linkin Park's new song 'Heavy' a nod of approval.
Loudwire descended upon the 2017 NAMM Show in Anaheim, Calif., over the four-day period of Jan. 19-22.
See fan-shot footage of Corey Taylor, Gavin Rossdale, Joe Elliott and Angelo Moore performing at the 'Celebrating David Bowie' tribute in Los Angeles.
Stone Sour's new album will be titled 'Hydrograd' and frontman Corey Taylor has provided an update on how far along the band is in the studio.
Korn have shared a video of Jonathan Davis and Slipknot's Corey Taylor laying down vocals for 'A Different World' in the studio.
I like Christmas for the kids, BUT …It is way too commercialized and it makes people very angry trying to run around and make other people happy. Christmas is for children, and I am happy to make sure it makes their day.
There's no slowing down Corey Taylor, who wrote a song for Robbie Williams and has ambitions for a country album among a wealth of other ideas.
During a recent interview, Taylor expressed regret for calling Rubin 'overrated' and 'overpaid' while performing a spoken-word gig in 2011.
After much consideration, Loudwire is proud to announce our endorsement for President of the United States.
In Corey Taylor's own words, the book will focus on 'how bats—t crazy my country is right now — in good ways and in bad ways.'
According to Corey Taylor, the only things that halted the Anthrax collaboration were management and record label reps, who wanted a new Slipknot album.
Corey Taylor was the guest on Scott Ian's SiriusXM show 'Never Meet Your Heroes,' candidly opening up about past struggles with alcoholism and his ego.


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Wall St. drifts before long weekend; consumer stocks up
U.S. stocks ended little changed on Friday ahead of the long holiday weekend, though indexes ended a two-week streak of losses and consumer shares were strong for a second day.
WASHINGTON The U.S. Supreme Court on Friday agreed to decide what federal prosecutors need to prove in order for someone to be convicted of bank fraud under federal law.
The court agreed to hear the case of Kevin Loughrin, who was convicted in Salt Lake City, Utah, of six counts of bank fraud for stealing checks that he then altered so he could purchase merchandise at Target Corp (TGT.N) stores.
Loughrin's lawyers say federal prosecutors should have to prove that their client intended to defraud the banks under which the checks were issued. Federal appeals courts are split on the intent-to-defraud question.
Loughrin told police that his aim was to purchase products using the checks and then return the items for cash refunds. He was charged with using altered checks totaling $1,184.
At trial, he argued that although Target suffered a loss, the banks under which the checks were issued did not because Target never submitted them for payment. Loughrin was sentenced to three years in prison.
The 10th U.S. Circuit Court of Appeals upheld his conviction in a March 13 ruling.
Loughrin is not appealing his related convictions for identity theft and possession of stolen mail.
Loughrin carried out the scheme with an accomplice, Theresa Thongsarn, who is not part of the appeal. She pleaded guilty, according to one of Loughrin's lawyers.
A Supreme Court decision is expected by the end of June.
The case is Loughrin v. United States, U.S. Supreme Court, 13-316.
(Reporting by Lawrence Hurley; Editing by Howard Goller and John Wallace)
U.S. stocks ended little changed on Friday ahead of the long holiday weekend, though indexes ended a two-week streak of losses and consumer shares were strong for a second day.
TORONTO The Toronto Stock Exchange's efforts to win a slice of the massive Saudi Aramco public listing plays up the country's deep experience in natural resources as part of a broader offer to help the kingdom with its shift away from oil dependence.
Billionaire Carlos Slim is looking to sell a minority stake in Telesites SAB de CV , the Mexican wireless tower company that he controls, people familiar with the matter said on Friday.


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End of Retail has these gorgeous Mint Rose Earrings for $3!!!! Plus, they charge $2 shipping per item…what a steal!
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Senior Manufacturing Engineer Salary
Senior Manufacturing Engineers in the United States tend to have a good amount of experience under their belt — just below two-thirds have more than 10 years in the field. While pay runs from $72K to $114K per year, median earnings come to $89K per year. Including potential for bonuses and profit sharing — peaking near $12K and $10K, respectively — total cash payment to Senior Manufacturing Engineers can bottom out near $72K or peak near $114K depending on individual performance. The most important factor affecting compensation for this group is location, followed by the company and years of experience. Most workers in this position report high levels of job satisfaction. Almost all report receiving medical coverage from their employers and a large number collect dental insurance. The information for this snapshot was generated by responses to the PayScale salary survey.
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|$70,954 - $108,818
|$102.13 - $11,835
|Profit Sharing
|$511 - $10,161
|Total Pay (
XTotal Pay combines base annual salary or hourly wage, bonuses, profit sharing, tips, commissions, overtime pay and other forms of cash earnings, as applicable for this job. It does not include equity (stock) compensation, cash value of retirement benefits, or the value of other non-cash benefits (e.g. healthcare).)
|$71,718 - $114,260
|Hourly Data
|Hourly Rate
|$26.32 - $58.06
|$36.84 - $71.10
|Annual Data
|$102.13 - $11,835
|Profit Sharing
|$511 - $10,161
|Total Pay (
XTotal Pay combines base annual salary or hourly wage, bonuses, profit sharing, tips, commissions, overtime pay and other forms of cash earnings, as applicable for this job. It does not include equity (stock) compensation, cash value of retirement benefits, or the value of other non-cash benefits (e.g. healthcare).)
|$71,718 - $114,260
Job Description for Senior Manufacturing Engineer
A senior manufacturing engineer is an executive who works in a company's production operations. They handle the monitoring and maintenance of technical aspects of the manufacturing process, looking at a variety of metrics gathered throughout the process. They coordinate and integrate the manufacturing process, as well as analyze efficiency data and process flow. They usually work with a manufacturing manager to ensure that a company's standards for manufacturing are maintained, as well as in developing new production methods and implementing new product processes.Read More...
This position typically requires a bachelor's degree in a relevant engineering field, such as industrial or chemical engineering. Some larger companies may prefer their engineers to receive post-graduate administration degrees as well. The senior manufacturing engineer is the person tasked with implementing, monitoring, and introducing new production systems, and thus they should have excellent organization skills and be good communicators.
They may also interface with other parts of the company as well. They often analyze issues such as customer relations claims regarding a company's products, making improvements as necessary. They work with development to implement systems for the manufacturing new products, and they work with the manufacturing manager and the purchasing department to acquire new materials and equipment necessary to safely and efficiently create new goods and maintain the most efficient processes for manufacturing of existing goods. They also help the manufacturing manager maintain production standards by the continual monitoring of equipment operation to ensure that all process flow and production systems are operating at peak.
Senior Manufacturing Engineer Tasks
- Define, analyze, and propose solutions to engineering problems.
- Monitor and evaluate equipment and materials to ensure optimal results.
- Manage and lead complex projects involving cross-functional teams.
- Perform calculations and evaluations to propose new projects and increase efficiency.
Common Career Paths for Senior Manufacturing Engineer
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Senior Manufacturing Engineers' salary tends to stay somewhat level for those who assume higher-end positions like Manufacturing Engineering Manager. Median pay for Manufacturing Engineering Managers is $96K. Senior Manufacturing Engineers most frequently advance into Operations Manager and Project Engineer roles even though the median salaries are $32K lower and $24K lower, respectively.
Senior Manufacturing Engineer Job Listings
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Popular Employer Salaries for Senior Manufacturing Engineer
Senior Manufacturing Engineers fill the offices of leading firms Eaton Corporation, Medtronic, Inc., General Electric Co (GE), Lockheed Martin Corp, and General Motors Corporation. Senior Manufacturing Engineers seeking a sizable paycheck can earn the most at General Motors Corporation, where the average salary comes to $107K.
Offering a median salary of only $75K, Eaton Corporation pays the least. Not only that, but the earnings range of $59K to $124K is pretty narrow, too.
Popular Skills for Senior Manufacturing Engineer
Survey takers working as Senior Manufacturing Engineers report using a large range of professional skills. Most notably, skills in Microsoft Word, Microsoft Office, Six Sigma Black Belt, and Microsoft Excel are correlated to pay that is above average. Skills that seem to negatively impact pay include AutoCAD and CAD/CAM. Most people familiar with Lean Manufacturing also know Project Management.
Pay by Experience Level for Senior Manufacturing Engineer
Pay by Experience for a Senior Manufacturing Engineer has a positive trend. An entry-level Senior Manufacturing Engineer with less than 5 years of experience can expect to earn an average total compensation of $82,000 based on 134 salaries provided by anonymous users. Average total compensation includes tips, bonus, and overtime pay. A Senior Manufacturing Engineer with mid-career experience which includes employees with 5 to 10 years of experience can expect to earn an average total compensation of $88,000 based on 235 salaries. An experienced Senior Manufacturing Engineer which includes employees with 10 to 20 years of experience can expect to earn an average total compensation of $94,000 based on 285 salaries. A Senior Manufacturing Engineer with late-career experience which includes employees with greater than 20 years of experience can expect to earn an average total compensation of $97,000 based on 204 salaries.
Pay Difference by Location
For Senior Manufacturing Engineers, busy San Francisco offers a higher-than-average pay rate, 39 percent above the national average. Senior Manufacturing Engineers will also find cushy salaries in Redwood City (+26 percent), San Jose (+16 percent), Houston (+13 percent), and San Diego (+6 percent). Wichita is home to the smallest salaries in the field, lagging the national average by 20 percent. Workers in Charlotte and Chicago earn salaries that trail the national average for those in this profession (12 percent less and 6 percent less, respectively).
Related Job Salaries
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Key Stats for Senior Manufacturing Engineer
10 %
90 %
Job Satisfaction
|Highly satisfied
Rated 4 out of 5
based on 74 votes.


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Logement entier
4 voyageurs
2 chambres
3 lits
Logement entier
4 voyageurs
2 chambres
3 lits
À propos de ce logement
A small family of two adults and two children live in this 100 sq meters apartment in best part of Nørrebro. Large kitchen and bathroom. Two living rooms and two bedrooms. Overlooking playgrounds and courtyard + walking distance parks and gardens.
Le logement
Capacité d'accueil : 4
Salles de bain : 1
Chambres : 2
Lits : 3
Type de logement : Logement entier
Voyageur supplémentaire : Sans frais
Frais de ménage : 65€
Réduction à la semaine : 15%
Communiquez toujours via Airbnb
Pour protéger votre paiement, ne transférez jamais d'argent et n'établissez pas de contact en dehors du site ou de l'application Airbnb. En savoir plus
Règlement intérieur
Non fumeur
Ne convient pas aux animaux
Pas de fête ni de soirée
Si vous annulez jusqu'à 24 heures avant le voyage, vous recevez un remboursement intégral, frais de service compris.
Séjour de 5 nuits minimum
L'adresse exacte est communiquée uniquement lorsque la réservation est confirmée.
1 commentaire
Ida was an excellent host. Very kind, considerate, and accessible. She provided us detailed instructions of the place, which made our life very easy, and a long list of local attractions, which made our stay very interesting. She responded fast whenever we had questions or problems before arrival and during our stay. We liked the place very much. The apartment was even better than we had expected from the photos. What makes this apartment very pleasant is the open-space feeling, which is somewhat difficult to sense from the pictures. Windows facing northeast, southeast, and west bring lots of natural light and pleasant breeze. The apartment has everything we needed and they were very well organized. The kitchen was equipped with all the necessary tools and machineries, and all the essentials such as oil, spice and all kinds of sauces. We really enjoyed cooking here. Lastly, the host has two small children and this made this place a perfect fit for us. Kids-friendly and thoughtfully prepared: Kids'room was filled with all kinds of toys that our 2-year old daughter had full access to, and the living room even had a swing hung from the ceiling. Ida also prepared everything to make sure that we could start the no-hassle life with a toddler right away: a foldable bath for a baby, a baby cot and also the changing table had all the necessities (diapers, wipes, plastic bags and plenty of towels). She also gave us a detailed list of the local good playgrounds and facilities for kids which was really helpful when traveling with kids. We were very thankful to Ida for how much effort she had made for our stay. Nørrebro is a very interesting place to stay in Copenhagen, with great diversity. While many immigrants live in the area, there are great cafes and restaurants popular to local Danes. We enjoyed both high-end bakeries and bottom rock shawarma place (which offers quite tasty and authentic Turkish food). Surrounding the apartment are many playgrounds and parks, where we had a very nice time with our daughter. In terms of the location, you should be prepared to use bus or bicycle: walking to the city center (e.g. Strøget and Tivoli) takes around half an hour and is indeed very nice but you don't want to do it every day.
Copenhague, Danemark · Membre depuis février 2013
Loves travelling - especially with my boyfriend Troels and our son Frode.
Découvrez d'autres options à Copenhague et dans ses environs
Plus de logements à Copenhague :


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Logo! 4 Foundation Workbook (Pack of 8)
Written by
Illustrated by
Part of the Logo! for Key Stage 4 Series
Lovereading4kids Price £28.99In Stock
Delivery time 1-2 weeks
Logo! 4 Foundation Workbook (Pack of 8) byThese workbooks provide exam-style reading and writing activities, extra grammar practice and practice questions to help students prepare for the speaking tests. The workbooks should be useful revision aids.
About the Author
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Book Info
Contains 8 copies of Paperback
Heinemann an imprint of Pearson Education Limited
Publication date
27th June 2001
It is fantastic, you get to read lots of books and you always find something new and amazing in them.Erica Motoc, age 7
I think Lovereading4kids is an amazing company because of the friendly staff and the fabulous chance to read great books before publication.Adam Graham
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I love lovereading4kids because I've read amazing books I would never have picked up, and its opened doors to new genre's I now love.Harriet Cunningham
Lovereading4kids is great, we get books really early never late. We love to read and review, and think you would like it too. The excitementJasmine Harris-Hart, age 12
Love "Lovereading4kids" as my son gets to hear about & read new books before his mates which keeps him interested in reading=a very happy MumLiz Evans
It has introduced my children to books we hadn't come across before. Real children's reviews gives a great insight into what others think toLorraine Woods
A great way to introduce kids to great books, authors & genres. Parents can find age-appropriate books to share with their children.Judi Davies – Aberdare Girls Sch