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Question about Televison & Video
Posted by roger31 on
I have a polaroid flm3232 it doesnt power up, sounds likepower supply.
is there a power supply rebuild kit, i pulled the power supply out and chk for cold solder joints, and so no exterior damage. Do you repair the power supplies, or can you point me in the right direction on component failure on this tv??
I have a FLM-3232 won't power on. The fuse was blown so I replaced it. Now it won't work.
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
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Explore these ideas and much more!
Bitkos by EDGAR KATKOV
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Irene Adler: The modern businesswoman || good lord, I have never heard these words, but they stir something deep in my soul.
Silver Erva. …
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artwork Tom Clancy's The Division
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ArcheAge Gold http://www.igvault.it/?a_aid=yixiu&a_bid=8c89305e
Definitely reminds me of a more modern Liri and Salihn


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|Publication number
|Publication type
|Application number
|Publication date
|Mar 5, 2002
|Filing date
|May 3, 1999
|Priority date
|Jun 17, 1998
|Fee status
|Also published as
|Publication number
|Pamela Wang Anderson
|Original Assignee
|Eli Lilly And Company
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (20), Non-Patent Citations (37), Referenced by (13), Classifications (18), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This Application claims the benefit of U.S. Provisional Application No. 60/089,601, filed Jun. 17, 1998.
The present invention deals with the disciplines of medicinal chemistry, cardiovascular physiology, and pharmacology. Specifically, the present invention is related to decreasing known risk factors of cardiovascular disease and other related symptoms associated with increased levels of homocysteine and C-reactive protein by administering certain 2-aryl-3-aroylbenzo[b]thiophenes.
Cardiovascular disease is a major cause of death in the United States and a major source of morbidity, medical cost, and economic loss to millions of people. Two of the most common and destructive aspects of cardiovascular disease are the appearance of atherosclerosis and thrombolitic events.
In recent years, a great deal of progress has been achieved in the treatment of cardiovascular disease. This progress has been possible not only because of the advancement of therapeutic intervention in the disease mechanisms, but also through the early identification of patients at risk of developing the disease. Indeed, patient risk identification and early treatment are important features of modern medical practice. Over the last twenty years, a variety of factors and clinical parameters have been identified which correlate with either the current state or the future probability of developing cardiovascular disease. Such risk factors may include measurable biochemical or physiological parameters, e.g., serum cholesterol, HDL, LDL, fibrin levels, etc., or behavioral of life-style patterns, such as obesity, smoking, etc. (For further information see: "Cardiovascular risk factors in the elderly", Kannel W., Coronary Artery Disease, 8:565-575, 1997 and references cited therein.) Risk factors most germane to the present invention are levels of homocysteine and C-reactive protein.
The intrinsic relationship between a measurable parameter or risk factor and the disease state is not always clear. In other words, it is not always clear whether the risk factor itself is causative or contributory to the disease or is instead an ancillary reflection that is indicative of the disease. Thus, a therapeutic modality, which effects a risk factor, may be directly modifying a pathological mechanism of the disease and its future course, or may be indirectly benefiting some contributory process related to the disease.
Additionally, many risk factors associated with cardiovascular disease are involved in other pathological states in either a causative or indicative role. Therefore, improvement in a particular risk factor in cardiovascular disease may have other beneficial effects in other diseases related to that risk factor. For example, several conditions are known to be associated with abnormally high homocysteine levels, including genetic defect, menopause, hypercholesterolemia, smoking, hypertension, renal failure, and deficiencies in vitamins B6, B12, and folic acid.
Of particular interest to the methods of the present invention is the reduction of cardiovascular risk factors associated with abnormally high levels of homocysteine and C-reactive protein. It has been shown in a number of clinical studies that high levels of homocysteine in the blood are positively linked with cardiovascular disease. Furthermore, in patients suffering from genetic abnormalities which cause an increase in homocysteine (homocysteinuria), there is a great increase of early onset cardiovascular disease and other pathological conditions, inter alia, occular pathologies, skeletal and peridontal abnormalities, central nervous system irregularities, etc.
Homocysteine is also an intermediate found in the biochemical pathway related to the synthesis of the amino acids glutathione, methionine, and cysteine. Abnormally high levels of homocysteine is indicative of a metabolic disorder in the biochemical synthesis of these amino acids and is, thus, predictive of disease states associated with abnormally low levels of these amino acids. For example, glutathione has known bio-protective anti-oxidant properties such as the cyto-protection of monocytes and macrophages from oxidized low density lipoproteins (LDL). The oxidative action of oxidized LDL's on monocytes and macrophages is thought to be a pathological mechanism in atherosclerotic arterial damage.
C-reactive protein is produced by the liver in response to cytokine production. Cytokines are produced as part of an inflammatory response in the body. Thus, C-reactive protein levels are a marker of systemic inflammatory activity. Chronic inflammation is thought to be one of the underlying and sustaining pathologies in cardiovascular disease.
At menopause, with the loss of estrogen, women's prevalence of cardiovascular disease increases. Also, the risk factors of cardiovascular disease increase, especially lipid (cholesterol and triglyceride), homocysteine, and C-reactive protein levels. Today, the most common method of preventing cardiovascular disease in post-menopausal women is Hormone Replacement Therapy (HRT). However, many women do not comply with this therapy because of the unpleasant side-effects, such as bloating, resumption of mensus, breast tenderness, fear of uterine and breast cancer, etc. Additionally, while HRT does lower cholesterol and homocysteine levels, HRT raises C-reactive protein levels. A new therapeutic agent which lowers these risk factors would be beneficial.
The present invention provides methods for decreasing levels of homocysteine and C-reactive protein in humans comprising administering to a human in need thereof an effective amount of a compound of formula I:
or a pharmaceutical salt or solvate thereof; wherein:
R1 and R3 are independently hydrogen, methyl, benzoyl, substituted benzoyl, or C(O)-(C1-C6 alkyl);
R2 is selected from the group pyrolidin-1-yl, piperidin-1-yl, and hexamethyleneimin-1-yl; where the R2 group is optionally the N-oxide.
Further, the present invention relates to a method for inhibiting conditions or detrimental effects caused by an excess of homocysteine and/or C-reactive protein comprising administering to a human in need thereof, an effective amount of a compound of formula I, or a pharmaceutical salt or solvate thereof.
The present invention is related to the discovery that a select group of 2-aryl-3-aroylbenzo[b]thiophenes, i.e., the compounds of formula I, are useful for lowering the levels of homocysteine and C-reactive protein.
As used herein, the term "effective amount" means an amount of a compound of formula I which is capable of decreasing levels of homocysteine and/or C-reactive protein and/or inhibiting conditions or detrimental effects caused by an excess of homocysteine and/or C-reactive protein.
The term "estrogen deficient" refers to a condition, either naturally occurring or clinically induced, where a woman can not produce sufficient estrogenic hormones to maintain estrogen dependent functions, e.g., menses, homeostasis of bone mass, neuronal function, cardiovascular condition, etc. Such estrogen deficient situations arise from, but are not limited to, menopause and surgical or chemical ovarectomy, including its functional equivalent, e.g., medication with GnRH agonists or antagonists, ICI 182780, and the like.
The term "inhibiting" in the context of inhibiting conditions or detrimental effects caused by an excess of homocysteine and/or C-reactive protein includes its generally accepted meaning, i.e., prohibiting, restraining, alleviating, ameliorating, slowing, stopping, or reversing the progression or severity of an increase of homocysteine and/or C-reactive protein and the pathological sequelae, i.e., symptoms, resulting from that event.
General terms used in the description of compounds herein described bear their usual meanings. For example, "C1-C6 alkyl" refers to straight, branched, or cyclic aliphatic chains of 1 to 6 carbon atoms including methyl, ethyl, propyl, iso-propyl, cyclopropyl, n-butyl, pentyl, hexyl and the like.
The term "substituted benzoyl" refers to benzoyl group having one to five substituents selected independently from the group: C1-C4 alkyl, C1-C4 alkoxy, hydroxy, nitro, chloro, fluoro, or tri(chloro or fluoro)methyl.
The term "pharmaceutical" when used herein as an adjective, means substantially non-toxic and substantially non-deleterious to the recipient.
By "pharmaceutical formulation" it is further meant that the carrier, solvent, excipients and salt must be compatible with the active ingredient of the formulation (a compound of formula I).
The term "acid addition salt" refers to a salt of a compound of formula I prepared by reaction of a compound of formula I with a mineral or organic acid. For exemplification of pharmaceutical acid addition salts see, e.g., Berge, S. M, Bighley, L. D., and Monkhouse, D. C., J. Pharm. Sci., 66:1, 1977.
The term "solvate" represents an aggregate that comprises one or more molecules of the solute, such as a formula I compound, with one or more molecules of a pharmaceutical solvent, such as water, ethanol, and the like.
The methods provided by the present invention are useful in the treatment and prevention of pathologies associated with elevated levels of homocysteine (homocysteinuria). Harmful sequelae related to homocysteinuria, inhibited by the methods of the current invention, include, but are not limited to, ocular disorders (ectopia lentis, myopia, retinal detachment, g aucoma), skeletal disorders (scoliosis, dolic ostenomelia, osteoporosis) central nervous system defects, and the like.
The methods provided by the current invention are useful in both the treatment and prevention of harmful sequelae associated with elevated levels of C-reactive protein. Since C-reactive protein serum concentration is related to levels and production of cytokines which are especially produced in inflammatory processes, the methods of the current invention are useful in treating or preventing inflammatory events and sequelae, thereof. Such inflammatory events include, but are not limited to: arthritis (osteo and rheumatoid), arterial and venous chronic inflammation, auto-immune diseases, e.g., SLE, etc., and the like.
Methods of the current invention are useful for treating or preventing pathologic sequelae of atherosclerotic or thrombotic disease. Such pathologies include, but are not limited to stroke, circulatory insufficiency, ischemic events, myocardial infraction, pulmonary thromboembolism, stable and unstable angina, coronary artery disease, sudden death syndrome, and the like.
The present invention further contemplates the use of other currently known clinically relevant agents administered to treat the pathological conditions embodied in the present invention in combination with a compound of formula I.
Moreover, the present invention contemplates that the compounds of formula I are employed in either a treatment or prophylactic modality.
A preferred embodiment of the present invention is where the human to be administered a compound of formula I is female, and more preferred is when that human female is estrogen deficient.
Another preferred embodiment of the present invention is where the condition caused by an abnormally high level of homocysteine or C-reactive protein is cardiovascular disease, especially atherosclerosis and thrombosis. A particularly preferred embodiment of the present invention is the use of a compound of formula I in an estrogen deficient women, who is receiving estrogen or HRT, for the reduction of systemic or local inflammation.
Moreover, another preferred embodiment of the present invention is the use of a pharmaceutical acid addition salt of a compound of formula I where R1 and R3 are hydrogen and R2 is pyrolidin-1-yl. More preferably, the salt is the hydrochloride. This more preferred compound is named [2-(4-hydroxyphenyl)-6-hydroxybenzo [b]thien-3-yl][4-[2-(1-pyrolidinyl)ethoxy]phenyl]methanone hydrochloride.
An even more preferred embodiment of the present invention is the use of a pharmaceutical acid addition salt of a compound of formula I where R1 and R3 are hydrogen and R2 is piperidin-1-yl. Most preferably, the salt is the hydrochloride. This most preferred compound is named [2-(4-hydroxyphenyl)-6-hydroxybenzo [b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride or raloxifene hydrochloride.
Compounds of formula I where R and/or R3 are hydrogen or methyl may be prepared according to known procedures, such as those detailed in U.S. Pat. Nos. 4,133,814, 4,418,068, and 5,731,342, the teachings of each are herein incorporated by reference. The compounds of formula I which are carboxylic esters (R1 and/or R3 are C(O)-(C1-C6 alkyl), benzoyl, or substituted benzoyl) may be prepared from compounds of formula I where R and/or R3 are hydrogen by methods described in U.S. Pat. No. 5,393,763, the teachings of which are herein included by reference.
The pharmaceutical acid addition salts of the invention are typically formed by reacting a compound of formula I with an equimolar or excess amount of acid. The reactants are generally combined in a mutual solvent such as diethylether, tetrahydrofuran, methanol, ethanol, isopropanol, benzene, and the like. The salts normally precipitate out of solution within about one hour to about ten days and can be isolated by filtration or other conventional methods.
Acids commonly employed to form acid addition salts are inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like, and organic acids such as p-toluenesulfonic, methanesulfonic acid, ethanesulfonic acid, oxalic acid, p-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, tartaric acid, benzoic acid, acetic acid, and the like.
Pharmaceutical formulations can be prepared by procedures known in the art, such as, for example, in EP Published Application 670162A1, published Sep. 6, 1995, and in WO 97/35571 published Oct. 2, 1997, both of which are herein incorporated by reference. For example, a compound of formula I can be formulated with common excipients, diluents, or carriers, and formed into tablets, capsules, and the like.
Examples of excipients, diluents, and carriers that are suitable for formulation include the following: fillers and extenders such as starch, sugars, mannitol, and silicic derivatives; binding agents such as carboxymethyl cellulose and other cellulose derivatives, alginates, gelatin, and polyvinyl pyrrolidone; moisturizing agents such as glycerol; disintegrating agents such as agar, calcium carbonate, and sodium bicarbonate; agents for retarding dissolution such as paraffin; resorption accelerators such as quaternary ammonium compounds; surface active agents such as cetyl alcohol, glycerol monostearate; adsorptive carriers such as kaolin and bentonire; and lubricants such as talc, calcium and magnesium stearate and solid polyethyl glycols. Final pharmaceutical forms may be: pills, tablets, powders, lozenges, syrups, aerosols, saches, cachets, elixirs, suspensions, emulsions, ointments, suppositories, sterile injectable solutions, or sterile packaged powders, depending on the type of excipient used.
Additionally, the compounds of formula I are well suited to formulation as sustained release dosage forms. The formulations can also be so constituted that they release the active ingredient only or preferably in a particular part of the intestinal tract, possibly over a period of time. Such formulations would involve coatings, envelopes, or protective matrices which may be made from polymeric substances or waxes.
The particular dosage of a compound of formula I required to decrease levels of homocysteine and/or C-reactive protein according to this invention will depend upon the particular circumstances of the conditions to be treated. Considerations such as dosage, route of administration, and frequency of dosing are best decided by the attending physician. Generally, an effective minimum dose for oral or parenteral administration of a compound of formula I is about 1, 5, 10, 15, or 20 mg. Typically, an effective maximum dose is about 800, 120, 60, 50, or 40 mg. A particularly effective amount is 60 mg of raloxifene hydrochloride (56 mg of free base) per day via an oral route of administration. Such dosages will be administered to a patient in need of treatment from one to three times each day or as often as needed to effectively decrease levels of homocysteine and/or C-reactive protein and/or inhibit conditions or detrimental effects caused by an excess of homocysteine and/or C-reactive protein.
The formulations which follow are given for purposes of illustration and are not intended to be limiting in any way. The total active ingredient in such formulations comprises from 0.1% to 99.9% by weight of the formulation. The term, "active ingredient" means a compound of formula I, or a pharmaceutical salt or solvate thereof, (preferably raloxifene hydrochloride). An even more preferred formulation of a compound of formula I would be raloxifene hydrochloride in the particular crystalline form, particle size, and composition illustrated in U.S. Pat. No. 5,731,327 and PCT application WO 97/35571 (Oct. 2, 1997) the teachings of each are incorporated by reference.
Formulation 1
Gelatin Capsules
Quantity (mg/capsule)
Active Ingredient
Starch NF
Starch flowable powder
Silicone fluid 350 centistrokes
The ingredients are blended, passed through a No. 45 mesh U.S. sieve, and filled into hard gelatin capsules.
Formulation 2
Quantity (mg/tablet)
Active Ingredient
Cellulose, microcrystalline
(as 10% solution in water)
Sodium carboxymethyl cellulose
Magnesium stearate
The active ingredient, starch, and cellulose are passed through a No. 45 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve. The granules thus produced are dried at 50-60� C. and passed through a No. 18 mesh U.S. sieve. The sodium carboxymethyl cellulose, magnesium stearate, and talc, previously passed through a No. 60 mesh U.S. sieve, are added to the above granules and thoroughly mixed. The resultant material is compressed in a tablet forming machine to yield the tablets.
Formulation 3
Weight %
Active Ingredient
Propellant 22
The active ingredient is mixed with ethanol and the mixture added to a portion of the propellant 22, cooled to −30� C. and transferred to a filling device. The required amount is then fed to a stainless steel container and diluted with the remainder of the propellant. The valve units are then fitted to the container.
Formulation 4
Active Ingredient
Sodium carboxymethyl
Benzoic acid solution (0.1M)
Purified water to total
Suspensions each containing 100 mg of a compound of formula I per 5 mL dose are prepared as follows: the active ingredient is passed through a No. 45 mesh U.S. sieve and mixed with the sodium carboxymethyl cellulose and syrup to form a smooth paste. The benzoic acid solution, flavor, and color diluted in water are added and mixture stirred thoroughly. Additional water is added to bring the entire mixture to the required volume.
The following demonstration of the methods of the present invention is presented for the purposes of illustration and is not intended to limit the scope of this invention in any way.
A clinical investigation was conducted which included 390 women (45-72 years old), who were an average of ten years postmenopausal. These patients were randomly assigned to the following treatment protocol: raloxifene hydrochloride at 60 mg per day via oral administration (cf. Formulation 2, supra), raloxifene at 120 mg per day, or HRT therapy. Homocysteine and C-reactive protein baseline levels were determined, prior to the initiation of therapy. Methods for such determinations are well known and can be found in the references cited, supra. The study was conducted for a period of six months. The levels of homocysteine and C-reactive protein in each patient were compared at the end of six months with that patient's baseline. Results were analyzed by variance. Raloxifene at 60 mg per day lowered levels of homocysteine by 8% (p<0.05) and C-reactive protein by 4% (NS). Raloxifene at 120 mg per day lowered homocysteine by 5.7% (p<0.05) and C-reactive protien by −3.9 (NS). HRT lowered homocysteine by 6.6% (p<0.05), but raised C-reactive protein by 84.1% (p<0.05).
|Cited Patent
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|Eli Lilly And Company
|2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
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|Synthesis of acylated benzothiophenes
|Dec 16, 1981
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|Antiestrogenic and antiandrugenic benzothiophenes
|Feb 24, 1988
|Dec 24, 1991
|University Of Pennsylvania
|Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
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|Eli Lilly And Company
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|Eli Lilly And Company
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|Eli Lilly And Company
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|Eli Lilly And Company
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|Nov 30, 1993
|Nov 7, 1995
|Eli Lilly And Company
|Methods for lowering serum cholesterol
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|Dec 19, 1995
|Eli Lilly And Company
|Methods of increasing thrombomodulin expression
|Mar 19, 1993
|Jan 9, 1996
|Eli Lilly And Company
|Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
|Feb 28, 1995
|Apr 23, 1996
|Eli Lilly And Company
|Benzothiophene compounds as anti-estrogenic agents
|Dec 19, 1994
|Jun 28, 1995
|Eli Lilly And Company
|2-Phenyl-3-azoylbenzothiophenes for increasing thombomodulin expression
|Dec 19, 1994
|Jul 26, 1995
|Eli Lilly And Company
|Inhibition of ldl oxidation and atherosclerosis
|Dec 19, 1994
|Jul 26, 1995
|Eli Lilly And Company
|Inhibition of thrombin
|Nov 3, 1997
|May 27, 1998
|Pfizer Inc.
|Use of estrogen agonists/antagonists for the manufacture of a medicament in the treatment of atherosclerosis independent of a lipid lowering effect
|Title not available
|Dec 1, 1992
|Jun 10, 1993
|Endorecherche Inc.
|Sex steroid activity inhibitors
|Apr 20, 1998
|Oct 29, 1998
|Eli Lilly And Company
|Methods for reducing fibrinogen
|Aug 17, 1998
|Feb 25, 1999
|Eli Lilly And Company
|Methods for lowering platelet counts
|"Randomized, double-blind, placebocontrolled study of the effects of raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women" Fertility and (Mijatovic et al.).
|Anderson, et al., "Raloxifene Favorably Alters SErum Lipids in Postmenopausal Women with Cardiovascular Risk Factors" Circulation 98, 1-7, Abstract 34 (1998).
|Black et al."Uterine Bioassay of Tamoxifen, and New Estrogen Antagonist (LY117018) in Rats and Mice, " Life Sciences, 26:1980, 1453-1458.
|Black et al., "Differential Interaction of Antiestrogens with Cytosol Estrogen Receptors," Molecular and Cellular Endocrinology, 22:1981, 95-103.
|Black et al., "Distinct, Structure-Related Profiles of Estrogenic and Anti-Estrogenic Activity in the Tamoxifen and LY117018 Series;" The Endocrine Society, Abstract 1982.
|Black et al., "Evidence for Biological Action of the Antiestrogens LY117018 and Tamoxifen by Different Mechanisms," Endocrinology 109;1981, 987-989.
|Black et al., Antagonism of Estrogen Action with a New benzothiophene Derived Antiestrogen, Life Sciences, 32:1983. 1031-1036.
|Black et al., Antiestrogens 2. Structure Activity Studies in a Series of 3-Aroyl-2-arylbenzo[b] thiophene Derivatives Leading to [6-Hydroxy-2-(4hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with Only Minimal Intrinsic Estrogenicity, J. Med. Chem. 27(8), 1984, 1057-1066.
|Black et al., LY156758: A Unique Antiestrogen Displaying High Affinity for Estrogen Receptors, Negligible Estrogenic Activity and Near-Total Estrogen Antagonism in Vivo. Presented at the Fifth Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, Nov. 5-6, 1982.
|Black et al., Synthesis and Antiestrogenic Activity of [3,4-Dihydro-2(4-methoxyphenyl)-1-napthalenyl] [4-[2-pyrrolidinyl)ethoxyl]-phenyl] methanone, methanesulfonic acid salt, Journal of Medicinal Cehmistry 22;1976, 962-966.
|Black et al., The Antiestrogenic Action of LY139481: Species Uniformity Duration of Action and Kinetics of 3H-LY139481 Distribution In Vivo. Sixty-fifth Annual Meeting of the Endocrine Society, San Antonio, Texas, Jun. 8-10, 1983, abs. 93.
|Black et al., The Relationship of the Antiestrogenic Efficacy of LY156758 to its Pharmacokinetics and Metabolism Following Oral Administration to Adult Ovariectomized Rats, Seventh International Congress of Endocrinology, Quebec City, Canada, Jul. 1-7, 1984, abs. 323.
|Black, L.J. "Biological Actions and Binding Properites of a New Estrogen Antagosist LY117018," In: Homone Antagonists, 129-82, 1982 (M.K. Agarwal ed.) Walter de Gruyter and Co., Berlin New York.
|Bryant et al., "Protection from Bone Loss and Lowering of Serum Cholecterol in the Absence of Uterine Stimulation in Ovariectomized Rats", Am Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
|Bryant et al., "Raloxifene is a Tissue Spectific Estrogen Agonist", Am Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
|Chae, et al., "Postmenopausal hormone replacement therapy and cardiovascular disease" Thrombosis and Haemostasis vol. 78, No. 1 pp. 770-780 (1997).
|Cummings, et al., "the Effect of Raloxifen on Risk Of Breast Cancer in Postmenopausal Women" Results from the More Randomized Trial, JAMA, vol. 281, No. 23 (1999).
|Database Dialog File 187, FDC Reports, Accession No. 00089403, vol. 55, No. 16, "Lilly's raloxifene entering phase III for osteoporosis" (1993).
|Database Dialog File 445, Dialog Accession No. 0004016, Products nearing market with Lilly (1993).
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|Draper et al., "Effects of Raloxifene (LY139481 HC1) on Biochemical Markers of Bone and Lipid Metabolism i Healthy Postmenopausal Women", Hong Kong, Fourth Int'l Symp. on Osteoporosis, Mar. 29, 1993.
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|Frolick et al., "In Vivo and In Vitro Metabolism of Raloxifene", Am. Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
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|Glasebrook et al., "Multiple Binding Sites fro the Anti-estrogen Raloxifene", Am Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
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|Hock et al., "Combination of Raloxifene and Hume Parathyoid Hormone 1-34; Increased Femur Bone Mass in Young Ovariectomized (OVX) Rats", Am. Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
|Kangas, et al., "Agonistic and Antagonistic Effects of Antiestrogens in Different Target Organs", ACTA Oncologica, vol. 31, No. 2, pp. 143-146 (1992).
|Mijatovic, et al., "Postmenopausal hormone replacement risk estimators for cornary artery disease and cardiovascular protection" Gynecological Endocrinology, vol. 13, pp. 130-144, 1999.
|Paul, et al, "Effects of Raloxifene and Hormone Replacement Therapy of Homocysteine and C-Reactive Protein Levels in Postmenopausal Women" Circulation 98, 1-7, Abstract 35 (1998).
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|Yang et al., "Raloxifene an Anti-Estrogen, Simulates the Effects of Estrogen in Inhibiting Bone Resorption Through Regulating TGFB-3 Expression in Bone;".Am Soc. for Bone and Min. Res., Tampa, Sep. 18-22, 1993.
|Citing Patent
|Filing date
|Publication date
|Apr 9, 2003
|Mar 27, 2007
|General Atomics
|Reversible inhibitors of SAH hydrolase and uses thereof
|Oct 13, 2004
|Apr 14, 2009
|General Atomics
|Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
|Jan 5, 2007
|Jan 11, 2011
|General Atomics
|Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
|Jan 5, 2007
|May 1, 2012
|General Atomics
|Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
|Apr 10, 2009
|Aug 20, 2013
|Mitsubishi Tanabe Pharma Corporation
|Homocysteine synthase inhibitor
|Apr 9, 2003
|Oct 14, 2004
|Chong-Sheng Yuan
|Reversible inhibitors of SAH hydrolase and uses thereof
|Oct 13, 2004
|Aug 18, 2005
|Chong-Sheng Yuan
|Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
|Dec 23, 2005
|Jan 4, 2007
|Carolyn Moore
|Methods for reducing c-reactive protein
|Jan 5, 2007
|Jun 7, 2007
|Chong-Sheng Yuan
|Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
|Jan 5, 2007
|Sep 6, 2007
|Chong-Sheng Yuan
|Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
|Aug 20, 2007
|Jul 17, 2008
|Chong-Sheng Yuan
|Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
|Aug 20, 2007
|Aug 14, 2008
|Chong-Sheng Yuan
|Use of reversible inhibitors of s-adenosyl-l-homocysteine hydrolase for treating lupus
|Apr 10, 2009
|Feb 10, 2011
|Mitsubishi Tanabe Pharma Corporation
|Homocysteine synthase inhibitor
|U.S. Classification
|514/324, 514/448, 514/410, 514/443, 514/422
|International Classification
|Cooperative Classification
|European Classification
|May 3, 1999
Owner name: ELI LILLY AND COMPANY, INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ANDERSON, PAMELA WANG;REEL/FRAME:009940/0841
Effective date: 19990426
|Sep 21, 2005
|Maintenance fee reminder mailed
|Mar 6, 2006
|Lapse for failure to pay maintenance fees
|May 2, 2006
|Expired due to failure to pay maintenance fee
Effective date: 20060305


text:
Since there is a veritable feast of new television coming in the next week, it seemed like as good a time as any to break down the changes to the schedule, day by day. Here is what's coming up in the next couple of weeks ...
Monday, August 13
Get ready for an influx of overly emotional moments set to Snow Patrol-esque music! Grey's Anatomy and Private Practice are back for new seasons, their eighth and fifth seasons respectively (TV2, 8.30pm and 9.30pm) - not my cup of tea, but I'm sure there are plenty who'll be happy with this news. For the more discerning viewer, Aaron Sorkin's much talked about new show The Newsroom begins with a pilot that drew mixed reviews from critics overseas (SoHo, 8.30pm); I'll be talking about it here, tomorrow.
Tuesday, August 14
Local reality TV is back with new seasons of fly-on-the-wall doco Coastwatch (One, 7.30pm) and surprisingly interesting What's Really in Our Food (TV3, 7.30pm). Later, British supernatural series The Fades wraps up a brilliant first season - sadly, it doesn't appear that it will be back for a second (UKTV, 9.20pm).
Wednesday, August 15
Did we ever figure out how to classify Deadliest Catch? Docu-thriller? Action-mentary? Either way, its back for its eighth season (Discovery, 7.30pm). Meanwhile, TV2 is bringing out a new batch of comedies - Hot in Cleveland is back with its second season (TV2, 8.pm), Charlie Sheen is back in an intriguing new series, Anger Management (TV2, 8.30pm), and Courteney Cox leads the cast of curiously-named comedy Cougar Town (TV2, 9pm).
Thursday, August 16
We're a few years behind, but Rescue Me returns for its sixth season (SoHo, 7.30pm). Gypsies continue to dominate the Thursday schedule, with The Big Gypsy Eviction (One, 8.30pm) following their removal from Dale Farm. If that's not your thing, Prime has the first of a two-part documentary about New Zealand's Paralympics team, Black & White (Prime, 8.30pm), followed by the second-half of True Blood's fifth season (Prime, 9.35pm).
Friday, August 17
The origins of conflicts between Israel and Palestine are explored in four-part British series The Promise (SoHo, 8.30pm), while Who Do You Think You Are USA starts up (Prime, 8.30pm). By the way, if you aren't watching it, Jono & Ben at Ten is surprisingly good, and improving every week - some of the complaints about content being derived from the web might be valid, but that doesn't mean you can't have a good laugh (TV3, 10pm).
Saturday, August 18/Sunday, August 19
Rising like a phoenix from the ashes of TVNZ 7, the Russell Brown-hosted Media3 started over the past weekend and is well worth your time (TV3, Saturdays at 10.30am - also repeated on Sunday nights). Since we don't already have enough second-rate reality shows on the schedule, Fear Factor (TV2, Saturday at 7.30pm), The Real Housewives of Orange County (Four, Saturday at 8.30pm), Mary Queen of Frocks (Vibe, Sunday at 8.30pm) and Gok Wan: Made in China (Living, Sunday at 9pm) are here to make sure reality fans are satisfied.
Next Week, August 20-24 ... and beyond
A few shows of note: Gordon Ramsay is back in two more timeslots with Masterchef USA (Prime, next Monday at 8.30pm) and Ramsay's Best Restaurant (One, next Wednesday at 8.30pm), Jaquie Brown hits screens to chronicle parenthood in Keep Calm & Carry On (One, next Wednesday at 8pm), and hit web series Auckland Daze gets a run on broadcast telly (One, next Thursday at 10.10pm) - I'd be more excited about that last one if a) it wasn't a year old, b) I hadn't seen it already, and c) TVNZ decided to pull Episodes mid-season to air it. Beyond that, look for new seasons of Hell on Wheels (Soho, starting August 26) and Boss (SoHo, startting September 1)
What are you looking forward to in the next couple of weeks?
Check out the latest edition of the NZ TV Power Rankings by clicking here.
Make sure you like On the Box on Facebook and add Chris on Twitter.
Or, feel free to email Chris with any questions or ideas.
This is a spoiler-free blog - please comment responsibly.
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TVNZ decided to pull Episodes mid-season to air it. NNNNOOOOOoooooo that show is insanely good, The *real* Matt LeBlanc is up there with Larry David which reminds me http://comediansincarsgettingcoffee.com/ has started
Episodes is being pulled??? WTF! I love that show, it is amazing! Why??? (throws coffee mug at wall in fury).
what Killerkiwi #1 said!
I'm looking forward to new seasons of Boss, Hell on Wheels and Copper starting soon, and a little after those a new show called The Last Resort.
Looking forward to also catching up on True Blood and Breaking Bad. Also at the end of next month I'll be look forward to new seasons of some old favs; Homeland, Boardwalk Empire, Big Bang Theory, Fringe and Dexter, so plenty to watch and record over the rainy winter and spring months to keep me going for a while.
What happened to Hawaii Five-0???
Killerkiwi #1: I'm no fan of monopolies, no sir, but Episodes is on the wrong channel here.
Episodes is another Prime cable offering from the USA and it's real home (in the absence of any competition) is SoHo where it will find it's true audience. Same goes for Homeland which struggled on TV3. I know, I know. I hate the true situation of it as well.
Episodes has just started Series 2 - why pull it after 2 episodes Counting on screening this week)? New timeslot?
Definitely looking forward to the new Jacqui Brown show - looks hilarious.
Hey Chris, any idea why TV3 has decided to pull Breakout Kings and Hawaii Five-0? H50 has 14 more episodes to go in S2. Not happy. :(
I have just watched Treme - season two and loved it. It was brilliant. Love the music and characters especially Sophia, Annie and best of all Antoine Batiste. I found it compelling engaging and entertaining - each episode like a night out down Bourbon Street. Hell I want to go to New Orleans and do bar work for six months in the lead up to Mardi Gras. Also watched Bored To Death - season two and loved it. Best episodes were near the end involving George's new limo driver and the trip to the Asian health spa was a hoot. What a shame it has been cancelled - and have you seen the annoying crap that is staying. I am looking forward to Charlie Sheen's Anger Management as a guilty pleasure but will drop it quickly if it insults me. What a shame Arron Sorkin's new show is on Soho - it should be available for ALL.
Three fishermen who died on ill-fated FV Jubilee were trapped in wheelhouse, inquiry finds
Fish farm assistant manager 'devastated' by illegal release of 6000 salmon
Defence blames 'manipulative' woman for death of Arran Gairns
Timaru Maori cultural centre hit by theft for second time
South Canterbury families, schools set to receive boosts under 2017 Budget
New Timaru police officers make immediate difference
Police seek sightings of three missing men in Christchurch, Timaru and North Otago
Timaru Boys' High School taught hockey lesson by Christ's College
Hand cyclist Jono Nelson happy with European performances
Alliance announces $2 million investment at North Otago plant
Timaru council encourages locals to contribute to tourism site
Pleasant Point Primary on top in 'rippa' rugby
Old Boys produce performance of season to dismantle unbeaten Point
South Canterbury's 1974 Ranfurly Shield winning coach Jim Dawson dies
We run the ruler over the Government's family income package
Melania Trump covered her head one day and not the next
Newstalk ZB: why haven't you sacked vile commentator Katie Hopkins
Man dies in Palmerston North after crashing into parked car
Army bomb disposal alert in Manchester turns out to be false alarm
Beauty products for when you're sick, but still have to face the world
In my beauty bag: Shortland Street actress Ria Vandervis
MPs will be responsible for deaths if they don't act, says group petitioning for mental health inquiry
Land slips destroying coastal stairways isolate Auckland's North Shore beaches
Ex-Black Cap Chris Martin gets ducks in a row for charity art auction
Best & worst dressed: The Bachelor NZ season three
Become a 'reducetarian': Ten countries to learn from
My Sunday routine: The Bachelor's Zac Franich
My Sunday routine: Macayla Chapman of Bird & Knoll
Claire Chitham: Return to Shortland Street, return to Waverley
Fish farm assistant manager 'devastated' by illegal release of 6000 salmon
Three fishermen who died on ill-fated FV Jubilee were trapped in wheelhouse, inquiry finds
Defence blames 'manipulative' woman for death of Arran Gairns
New Timaru police officers make immediate difference
Alliance announces $2 million investment at North Otago plant
South Canterbury families, schools set to receive boosts under 2017 Budget
Caroline Bay Carnival organisers doubtful about smoke free bay suggestion
Timaru council encourages locals to contribute to tourism site


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Gillian Wearing (CGAC and Fundación "la Caixa")
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Listen to free music played by zoja01
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @zoja01.
Feb 10, 2013 at 7:08 pm via YouTube | AMAZON | ITUNES
DeadP_ets gave props on Feb 16 at 10:03 am
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Nucleus Kernel Novell - Novell Netware Data Recovery Software recovers data from corrupt volume(s) of a crashed Novell Server. Kernel for Novell - Novell Data Recovery Software can recover and allows access to the data when the volume cannot be mount
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ECA has 220 members from 53 associations
Forgot your password?
ECA Executive Board (September 2015)
The ECA Executive Board is composed of 15 Members from different ECA Ordinary Member Clubs. 11 Members are elected by the General Assembly while 4 are appointed to represent ECA at the UEFA Professional Football Strategy Council. The ECA Executive Board Members are elected by their respective subdivision in accordance with the following table:
National Association Ranking
No. of Clubs
No. of Board Members
ECA Executive Board 2015-17The 106 ECA Ordinary Members elected a new Executive Board at the occasion of the 15th ECA General Assembly held on the 8th of September 2015 in Geneva. The eleven elected Board Members are joined by the four Members representing ECA at the UEFA Professional Football Strategy Council (PFSC). The four PFSC members are Nasser Al-Khelaifi (Paris Saint-Germain FC), Ivan Gazidis (Arsenal FC), Josep Maria Bartomeu (FC Barcelona) and Evgeni Giner (PFC CSKA Moskva). Following the elections, the new Executive Board appointed the Chairman and Vice-Chairmen.Chairman: Karl-Heinz Rummenigge | FC Bayern M�nchen (GER)
Vice-Chairman: Pedro L�pez Jim�nez | Real Madrid CF (ESP)
Vice-Chairman: Evgeni Giner | PFC CSKA Moskva (RUS)
Executive Board Members:
Note: Following the departure of Theodore Giannikos (former Olympiacos FC), the ECA Executive Board currently only counts 14 members. Elections will be held at the first General Assembly of the new membership cycle in September 2017.
ECA attends PACE hearing on Good Football Governance
ECA & UEFA to hold Legal Workshop in Marseille
First ever ECA Workshop on Club History & Museums held in Manchester
ECA Workshop on Club History & Museums to take place at Old Trafford
ECA presents results of latest study on Youth Academies
ECA kicks off Legal Workshop series in Romania
Leading the way for football clubs in Europe


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Favorite Places & Spaces
Fifty Best Practices for Living a Well-Designed Life | Day Designer® • 2016 Daily Planner
Coping skills - things to do when you're feeling down
DIY Teen Room Decor Ideas for Girls | Super Easy Crate Storage | Cool Bedroom Decor, Wall Art & Signs, Crafts, Bedding, Fun Do It Yourself Projects and Room Ideas for Small Spaces http://diyprojectsforteens.com/diy-teen-bedroom-ideas-girls
Great Books to Read idea for bullet journal! Color them in as you finish them.
Learn To Study The Bible
Hallway bookshelves
Cafe Beignet, New Orleans, Louisiana Just want to go to New ORleans! Been to Louisianna, just not here
Plants that help your home have fresh air. I need to find these!
How to study the Bible, this girl has great tips. Pin now, read later. :)
* Maria's Self *: DIY LUSH Bath Bombs / Fizzies Recipe


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Scoutmaster Musings
Trail Angel
Just as I found my way into Flagstaff I was walking up off the local trail system onto a city street. A jeep pulled up and I thought maybe it was the folks I'm to stay with tonight.
I was wrong. It was David L. who goes to NAU in Flag. He saw my blog and map and came to do trail magic. Out of the blue, for no reason than to make a hiker feel good, he met me with cold water and snacks (and his 2 dogs). How cool is that?! Someone that gives trail magic is often called a trail angel.
It doesn't take much to make a tired, thirsty hiker happy. That cold water was awesome since I just had a couple swallows left.
Thanks, David!
Posted: 0:01 04-20-2012 832
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Today, we've round up another compilation picture for you our lovely readers, Open Your Eyes And Your Heart To A Truly Precious Gift: Today, in this daily quotes category, we also provide some gallery post as the worst type of crying, don't rush anything, when the time is right, it'll happen, a friend who understands your tears, how happy you will be when the right one comes, you are perfect exactly as you are, and much other interesting stuf. So if you looking for new ideas about design, you must check it out at all.
What's next? Make sure you view all of the Open Your Eyes And Your Heart To A Truly Precious Gift: Today picture, and the full page gallery as well. Enjoy!


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Explore Sao Paulo, Spanish and more!
Explore related topics
Casa Independente - venda - São Paulo, Estado de São Paulo
Single Family Home for Sale at Lakefront Tuscan Villa, Ajijic, Lake Chapala…
3373 Rum Row, Naples, FL 34102 | Beautiful Port Royal Residence. Property consists of main house and guest house. Main house is located on one and a half Port Royal lots. The guest house is located on a separate single Port Royal lot. Both residences have among the very best long water views in Port Royal. Extraordinary boat dock facilities. Absolutely one of the most stunning homes in all of Port Royal.
Single Family Home for Sale at Spanish Style Oceanfront Home Nassau New Providence, Bahamas
Exterior of luxury home in Orlando, Florida
Exterior of luxury home in Ticino, Switzerland
Magnificent Bastide for sale in Saint-Paul de Vence located in an exclusive neighborhood of the area. A large plot, spacious living areas and a breathtaking view from the waters of the infinity pool. #Sale #SaintPaulDeVence #Bastide
Single Family Home for Sale at Magnificent Estate on Paradise Island Ocean Club…
Exterior of luxury home in West Palm Beach, Florida
Luxury home in Villefranche Sur Mer, France


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30-day memberships and group classes give exercisers a leg up on accomplishing their goals for fitness
Modern dance studio offers pole and aerial fitness classes, which strengthen cores through graceful poses and fluid movements
Facility boasts 16 squash courts, free weights, Cybex cardio equipment, and group fitness classes.
From the merchant: Retro fitness offers tanning, child sitting, classes, and training
CrossFit classes taught by certified instructors that provide a rotating regimen of high-intensity workouts
Professional staff is trained to help exercisers of all levels of ability achieve their fitness goals using the right tools
From the merchant: a 30-day membership for all kettlebell classes that will help build strength and conditioning
New clients get customized workouts from fitness instructors based on skill level; monthly membership provides unlimited gym use and classes
Access to fitness facility's workout equipment.
Pass grants access to kickboxing, martial arts, and fitness classes at a variety of studios throughout the country
From the merchant: We are dedicated to providing a welcoming fitness environment for women of all ages, shapes, and sizes.
Fitness classes that can be scaled to individual skill levels include circuit training, spinning, Pilates, cardio step, and Zumba
High-intensity 45-minute workouts send participants to 8 different exercise stations that strengthen upper-body muscles and burn fat
From the merchant: Experienced and creative instructors lead classes from sassy zumba classes to knockout, fun boxing for fitness classes!
Total Body Burn and Shed2Shred burn calories while sculpting the physique; Zumba classes set aerobic dance moves to Latin music
Trained professionals' mission is to create an environment to deliver high-quality healthcare services
Located in the heart of Federal Hill, right beside the Cross Street Market, this upscale boutique gym provides everything a busy health nut is looking for
Group fitness classes include cardio kickboxing, boot camp, and a heart-pumping Zumba dance workout
Classes combine strength training and cardiovascular conditioning, creating a full-body workout for almost any age or skill level
5-class pass allows students of all ability levels to gain access to a variety of fitness and martial arts classes at various locations
Kids and adults don uniforms and learn discipline during martial arts classes
Holistically minded trainer leads small group personal training classes—from yoga to cardio—along with personalized one-on-one sessions
Initiative strives to promote and facilitate strength and resistance training, core work, cardio, and greater flexibility
Trainers lead patrons of all abilities in 60-minute classes focused on developing strength, speed, agility, endurance, and nutrition
From the merchant: Brown and Healthy is a nonprofit organization providing community fitness sessions, wellness workshops & more!
Exercisers can burn fat and strengthen muscles during group fitness classes that focus on strength and conditioning
Local businesses like this one promote thriving, distinctive communities by offering a rich array of goods and services to locals like you
Fitness members enjoy customized workout programs, tailored to their goals by skilled trainers and delivered via mobile app
From the merchant: a 30-day membership for all HIIT classes gives exercisers a leg up on accomplishing their goals for fitness
Coaches help whip bodies into shape with supportive, challenging workouts
Class participants get fit while learning sensual floorwork or chair routines or practicing athletic feats on the pole
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German Chancellor Angela Merkel said Sunday that it was "unlikely" that the summit of European leaders could reach an agreement on a new Greek bailout.
"We must consider what the eurozone needs, and what Greece needs," Merkel told the press, arriving at the summit.
"We will all try our best -- whether it will succeed or not remains to be seen."
Source: Anadolu
GMT 19:32 2017 Tuesday ,16 MayEgyptian economic expert calls for supporting small, medium projects
GMT 16:09 2017 Tuesday ,16 MayLebanon's Governor of Central Bank says foreign reserves are stable
GMT 15:17 2017 Monday ,15 MayTunisian labor official denies demanding to change government
GMT 14:03 2017 Saturday ,13 MayMM Group's official says company has $ cash balance
GMT 05:25 2017 Saturday ,13 MayEgyptian official says banking sector developed 15 slums
GMT 04:29 2017 Thursday ,11 MayUS will aggressively enforce trade rules
GMT 15:48 2017 Tuesday ,09 MayEgyptian official praises efforts to control trade movement
GMT 19:44 2017 Monday ,08 MayEgyptian MP calls for re-operating suspended factories


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Marco Rubio Being "Thoroughly Vetted" as Potential VP, Says Romney
Well, this is strange.
Knowledgeable Republican sources tell me that Rubio is not being vetted by Mitt Romney's vice presidential search team. He has not been asked to complete any questionnaires or been asked to turn over any financial documents typically required of potential vice presidential candidates.
The timing was odd. Yesterday was also the release of Rubio's hotly anticipated memoir, An American Son. His publishing company at least almost certainly was hoping that buzz Rubio could be chosen as the GOP running mate would goose book sales, and we doubt anyone in the Rubio campaign is pleased the Romney camp decided to time the leak with his book release.
"I can't imagine who such people are, but I can tell you this: They know nothing about the vice presidential selection or evaluation process," Romneysaid from Michigan yesterday
. "The story was entirely false. Marco Rubio is being thoroughly vetted as part of our process."
Back in May, supposed Rubio insiders told BuzzFeed that Romneywas likely to chose a "boring white guy."
Rubio is of course a boring white guy, but apparently not boring or white enough.
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On May 23rd, 1967, the United States Air Force scrambled to ready nuclear missile-laden aircraft for deployment. Radar systems designed to detect incoming Soviet missiles had just been disrupted, in what the military perceived to be an act of war. But before any nukes were launched in retaliation, it seems Air Force command was told to stand down.
Just in the nick of time, the United States' newly minted Solar Forecasting Center was able to convey the true cause of the radar jamming: a rash of powerful solar flares. That's according to a new military history paper, which reveals for the first time just how close humanity came to annihilating itself because of space weather.
"This is what we would characterize as a really near miss," lead author Delores Knipp, a former Air Force officer and space weather physicist at the University of Colorado, Boulder, told Gizmodo.
Space weather is a catch-all term for a bunch of high-energy material the sun hurls our way during periods of heightened activity. It starts with a solar flare, which sends a burst of x-rays and ultraviolet light streaming off into space.
When a flare strikes the upper portion of our atmosphere, called the ionosphere, it acts like an EM pulse, ripping electrons off atoms and building up tremendous electrical charge.
This can cause radio devices to go dead, as Thomas Berger, director of the Space Weather Prediction Center at NOAA, told Gizmodo last summer:
Radio communications are sometimes impacted. Over the horizon radio becomes difficult. When airplanes are flying over the poles, the only way they communicate with control centers is high frequency radio waves bouncing over the continents. But it's just a temporary difficulty lasting ten minutes to hours at the most.


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Koeler maïs
Gerelateerde onderwerpen verkennen
THE BEST BASIC GRILLED CORN RECIPE: ~ From: "Serious Eats.Com". ~ Recipe Courtesy Of: "J. KENJI LOPEZ-ALT". ~ Posted On: July 25, 2013 ~ Active Time: 15 min; Grilling Time: 15 min; Total Time: 30 min; Yield: (8 servings).
A drinking game using a mug with cards spread in a circle around it. You go in a circle drawing a card and do what that card means. If you make a g...
Corn is a summer staple because it's the best there is. But you know what makes corn better than the best? Throwing it on a grill. Here's how it's done.
GRILLED CORN WITH GARLIC AND GINGER SOY-BUTTER: I use a relatively inexpensive naturally brewed Japanese shoyu (like Kikkoman will work fine). No need to break out the super fancy stuff as the flavor is muted with the other ingredients. Just don't use the cheap-o fake stuff like LaChoy.
Not only is this recipe very easy, it results in the kind of deep flavor associated with the crunchy street corn of Mexico In many parts of Mexico, though, that crunchiness is highlighted with a creamy chile-lime sauce This is more unusual than the tried, true and unbeatable butter-salt-and-pepper combination, and only slightly more complicated
Spice up your corn with Olive Oil and parmesan cheese for the most flavorful, EASY summertime side that can be made right at home on your grill!
Spanish Pasta Salad With Chorizo, Piquillo Peppers, and Pickled Onion | Serious Eats : Recipes
My tips for grilling fish will have you feeling confident and ready to grill your favorite fish recipe for your next meal.


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Russia ensuring rights of workers at FIFA World Cup construction sites — officialSport May 26, 3:08
Russian emergencies minister arrives in flood-hit southern RussiaWorld May 26, 2:56
NATO to join anti-IS coalition but unlikely to engage in combat — chiefWorld May 26, 0:23
Son of LUKOIL corporation co-owner tops list of Russia's richest legateesBusiness & Economy May 26, 0:23
Russian Foreign Ministry: OPCW not rushing to investigate chemical incident in SyriaRussian Politics & Diplomacy May 25, 21:28
Russia's legendary barque Kruzenshtern calls at Belgian portSociety & Culture May 25, 20:26
OPEC and non-OPEC countries to develop cooperation outside Vienna agreementBusiness & Economy May 25, 19:44
Russia squared-off with Western media blitz to smear World Cup preparationsSport May 25, 19:35
NATO seeks to continue and expand dialogue with RussiaWorld May 25, 19:01
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HAVANA, February 12. /TASS/. A fourth meeting between Patriarch Kirill of Moscow and All Russia and Cuban leader Raul Castro is underway in Havana, patriarch's spokesman Alexander Volkov said on Friday.
"The sides will discuss different topics, those on the agenda of the Russia Orthodox Church and Cuban government," Volkov said, adding that the story of the relations is "long and good."
Patriarch Kirill came to Cuba on February 11 and will stay till February 14 as part of his first pastor's visit to Latin American countries. He previously met with Castro in 2008 in Havana and in 2009 and 2015 in Moscow.


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Why do you elude me, my love?
Full Image - Twitter - Bonus - YouTube
Why do you elude me, my love?
Full Image - Twitter - Bonus - YouTube
Ajajaja delicius~!
Fuente: Pukeena Castro
The gleaming stars all about the shining moon
Hide their bright faces, when full-orbed and splendid
In the sky she floats, flooding the shadowed earth
with clear silver light.
birthday moodboard for the one and only @eveninglesbian
kelephant90 asked:
Hey Null do you like ice cream? *Passes a vanilla cone*
"Oh boy! I love ice cream!"
I eat too much 🎀
poroquagganbob asked:
What type of ice cream is Spheal's favorite? I want to feed him some!
Spheal likes Sundaes. Thanks!
i made a step by step guide to "ice cream" and "lamp" for a friend so i figured why not share it here too
just got a call from the manager! Got the job!!
Anyone else excited for summer?
Newest addition 👅 ft. bedhead
Edit by me: Lennon Black
Have fun with the reveal™ guys I'm going out for dinner and dancing.
i'm sorry but if you like mint ice cream, we can't be friends anymore.


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|By Marketwired .
Article Rating:
|January 15, 2013 05:13 PM EST
ST. PAUL, MN -- (Marketwire) -- 01/15/13 -- Alliance Bank, a privately owned community bank with over $590 million in assets, announced today the launch of Mobile Banking services for all personal banking customers.
Alliance Bank offers a variety of Mobile Banking tools for fast, easy, and secure access to personal banking accounts from anywhere. With Alliance Bank Mobile Banking, customers can accomplish the most common banking tasks such as checking available balances, transferring funds between accounts, and paying bills. To use Mobile Banking, customers must first be registered for Access Online banking.
Customers have several options on how to access their accounts through Mobile Banking. For iPhone® or Android users, the Alliance Bank app can be downloaded from their phone's app store. For mobile phone users with Internet access, the Mobile Web is available at m.alliancebanks.com. For users that have texting capabilities on their phone, Alliance Bank's Text Banking will allow customers to check balances and recent account transaction history simply by texting a letter code.
According to a recent Independent Community Bankers of America (ICBA) study, 37 percent of community banks currently offer mobile banking -- more than double the 15 percent that did in 2010. Another 44 percent of community banks plan to implement the service by 2014.
"As a community bank, we strive to offer the latest technology solutions to our customers," said V. Philip Reim, chief executive officer. "Our new Mobile Banking service provides our customers with the added flexibility of managing their banking activity from a variety of mobile devices. We're pleased to be able to offer this new, convenient service."
About Alliance Bank
Alliance Bank is a privately owned community bank with assets in excess of $590 million. Alliance Bank provides highly integrated commercial, agricultural, private and personal banking services through ten locations in Minnesota and Wisconsin.
Chartered in 1867, Alliance Bank delivers big bank expertise with community bank service. As a community bank, Alliance Bank is committed to remaining independent and providing personal interaction and timely decision making. From basic checking and savings products, to business loans, personal loans, sophisticated cash management and online banking services, Alliance Bank offers services to help companies and individuals succeed. Visit www.alliancebanks.com or call 1-888-959-9425 to learn more.
Debra Kosch
Vice President - Marketing
SYS-CON Events announced today that Systena America will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Systena Group has been in business for various software development and verification in Japan, US, ASEAN, and China by utilizing the knowledge we gained from all types of device development for various industries including smartphones (Android/iOS), wireless communication, security technology and IoT serv...
May. 29, 2017 03:30 AM EDT Reads: 1,065
SYS-CON Events announced today that Outscale will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Outscale's technology makes an automated and adaptable Cloud available to businesses, supporting them in the most complex IT projects while controlling their operational aspects. You boost your IT infrastructure's reactivity, with request responses that only take a few seconds.
May. 29, 2017 03:15 AM EDT Reads: 1,143
DevOps at Cloud Expo – being held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real r...
May. 29, 2017 02:30 AM EDT Reads: 1,363
SYS-CON Events announced today that delaPlex will exhibit at SYS-CON's @CloudExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. delaPlex pioneered Software Development as a Service (SDaaS), which provides scalable resources to build, test, and deploy software. It's a fast and more reliable way to develop a new product or expand your in-house team.
May. 29, 2017 12:00 AM EDT Reads: 5,265
Five years ago development was seen as a dead-end career, now it's anything but – with an explosion in mobile and IoT initiatives increasing the demand for skilled engineers. But apart from having a ready supply of great coders, what constitutes true 'DevOps Royalty'? It'll be the ability to craft resilient architectures, supportability, security everywhere across the software lifecycle. In his keynote at @DevOpsSummit at 20th Cloud Expo, Jeffrey Scheaffer, GM and SVP, Continuous Delivery Busine...
May. 28, 2017 11:30 PM EDT Reads: 4,024
SYS-CON Events announced today that Outscale, a global pure play Infrastructure as a Service provider and strategic partner of Dassault Systèmes, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Founded in 2010, Outscale simplifies infrastructure complexities and boosts the business agility of its customers. Outscale delivers a secure, reliable and industrial strength solution for its customers, which in...
May. 28, 2017 11:00 PM EDT Reads: 926
SYS-CON Events announced today that CollabNet, a global leader in enterprise software development, release automation and DevOps solutions, will be a Bronze Sponsor of SYS-CON's 20th International Cloud Expo®, taking place from June 6-8, 2017, at the Javits Center in New York City, NY. CollabNet offers a broad range of solutions with the mission of helping modern organizations deliver quality software at speed. The company's latest innovation, the DevOps Lifecycle Manager (DLM), supports Value S...
May. 28, 2017 10:45 PM EDT Reads: 6,326
In order to meet the rapidly changing demands of today's customers, companies are continually forced to redefine their business strategies in order to meet these needs, stay relevant and continue to see profitable growth. IoT deployment and development is integral in this transformation, and today businesses are increasingly seeing the value of investing their resources into IoT deployments. These technologies are able increase ROI through projects such as connecting supply chains or enabling sm...
May. 28, 2017 10:45 PM EDT Reads: 853
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
May. 28, 2017 10:30 PM EDT Reads: 5,549
Everywhere we turn in our industry we can find strong opinions about the direction, type and nature of cloud's impact on computing and business. Another word that is used in every context in our industry is "hybrid." In his session at 20th Cloud Expo, Alvaro Gonzalez, Director of Technical, Partner and Field Marketing at Peak 10, will use a combination of a few conceptual props and some research recently commissioned by Peak 10 to offer a real-world consideration of how the various categories of...
May. 28, 2017 10:15 PM EDT Reads: 1,369
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers' changing business needs, enabling them to lower costs, improve performance and focus intern...
May. 28, 2017 10:15 PM EDT Reads: 6,417
SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in compute, storage and networking technologies, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/...
May. 28, 2017 08:45 PM EDT Reads: 2,531
Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deli...
May. 28, 2017 08:30 PM EDT Reads: 5,357
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named "Gold Sponsor" of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer's customers range from Web startups to global enterprises.
May. 28, 2017 07:15 PM EDT Reads: 7,870
In his opening keynote at 20th Cloud Expo, Michael Maximilien, Research Scientist, Architect, and Engineer at IBM, will motivate why realizing the full potential of the cloud and social data requires artificial intelligence. By mixing Cloud Foundry and the rich set of Watson services, IBM's Bluemix is the best cloud operating system for enterprises today, providing rapid development and deployment of applications that can take advantage of the rich catalog of Watson services to help drive insigh...
May. 28, 2017 07:15 PM EDT Reads: 1,031
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend @CloudExpo | @ThingsExpo, June 6-8, 2017, at the Javits Center in New York City, NY and October 31 - November 2, 2017, Santa Clara Convention Center, CA. Learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
May. 28, 2017 04:30 PM EDT Reads: 5,560
SYS-CON Events announced today that EARP Integration will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. EARP Integration is a passionate software house. Since its inception in 2009 the company successfully delivers smart solutions for cities and factories that start their digital transformation. EARP provides bespoke solutions like, for example, advanced enterprise portals, business intelligence systems an...
May. 28, 2017 03:45 PM EDT Reads: 1,775
SYS-CON Events announced today that Progress, a global leader in application development, has been named "Bronze Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Enterprises today are rapidly adopting the cloud, while continuing to retain business-critical/sensitive data inside the firewall. This is creating two separate data silos – one inside the firewall and the other outside the firewall. Cloud ISVs oft...
May. 28, 2017 02:15 PM EDT Reads: 3,902
As cloud adoption continues to transform business, today's global enterprises are challenged with managing a growing amount of information living outside of the data center. The rapid adoption of IoT and increasingly mobile workforce are exacerbating the problem. Ensuring secure data sharing and efficient backup poses capacity and bandwidth considerations as well as policy and regulatory compliance issues.
May. 28, 2017 01:15 PM EDT Reads: 5,132
The 21st International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Machine Learning and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding busin...
May. 28, 2017 01:00 PM EDT Reads: 1,932


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May 24 at 5:30 PM
UU Alumni Chapter in SF/Bay Area invites you to a get together in Palo Alto
On May 24 our Alma Mater Uppsala University will honor its new PhDs and honorary doctors during the Conferment Ceremony - a huge event in Uppsala and well worth celebrating also in this part of the world!
May 30 at 1:15 PM – 2:30 PM
CV and Cover letter - be attractive!
CareerTuesday. A seminar on how to write your CV and Cover letter.
May 30 at 5:15 PM
DPCR Alumni community - Annual General Meeting
June 8 at 6:00 PM
All alumni mixer in New York
Join the Swedish Universities Alumni Chapters in New York City for an all alumni gathering! Come and mingle with alumni from Swedish Universities, while having a drink and a bite to eat!
June 8 at 6:30 PM
Uppsalian Gasque in Zurich
Uppsala University Switzerland Alumni Chapter is pleased to invite you to an Uppsalian Gasque at Zunfthaus zur Schmiden in Zurich, to meet with fellow alumni and friends and together celebrate the founding of our Alumni Chapter, on Thursday 8th of June 2017.
June 11 at 4:30 PM
Midsummer celebration in Hanoi
Please save the date for a traditional Swedish Midsummer celebration organised by the Swedish Alumni Network, the Swedish-Vietnamese Friendship Association and the Embassy of Sweden in Hanoi. Invitation and more information will be sent out soon.
June 28
Save the Date - Speaker event in New York
Dr. Trita Parsi on Obama, Iran and the Triumph of Diplomacy!
October 24 at 6:00 PM – 10:00 PM
Save the Date - Matariki Network Alumni Event in Boston, USA
Uppsala University invites you to an alumni event at the Harvard Museum of Natural History on Tuesday 24 October. This is a joint alumni event with the universities in the Matariki Network of Universities. The event will start with a lecture from a Dartmouth academic; this will be followed by a reception, during which attendees will have access to the Museum.