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Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis. However, there are no reports on whether coadministration of these drugs could potentiate each other's activities in alleviating pain and weight bearing deficits during arthritis.
LPS was injected to BALB/c mice intraperitoneally (i.p.) to induce thermal hyperalgesia. The hot plate test was used to study thermal nociception in naïve BALB/c and C57BL/6 mice and BALB/c mice with LPS-induced thermal hyperalgesia and to evaluate antinociceptive effects of drugs administered i.p. Monoarthritis was induced by injection of LPS intra-articularly into the right hind (RH) limb ankle joint of C57BL/6 mice. Weight bearing changes and the effect of i.p. drug administration were analyzed in freely moving mice using the video-based CatWalk gait analysis system.
In naïve mice indomethacin (5 to 50 mg/kg) had no significant activity, minocycline (25 to 100 mg/kg) produced hyperalgesia to thermal nociception, however, coadministration of minocycline 50 mg/kg with indomethacin 5 or 10 mg/kg produced significant antinociceptive effects in the hot plate test. A selective inhibitor of COX-1, FR122047 (10 mg/kg) and a selective COX-2 inhibitor, CAY10404 (10 mg/kg) had no significant antinociceptive activities to thermal nociception in naïve mice, however, coadministration of minocycline, with CAY10404 but not FR122047 produced significant antinociceptive effects. In mice with LPS-induced hyperalgesia vehicle, indomethacin (10 mg/kg) or minocycline (50 mg/kg) did not produce significant changes, however, coadministration of minocycline plus indomethacin resulted in antinociceptive activity. LPS-induced RH limb monoarthritis resulted in weight bearing (RH/left hind (LH) limb paw pressure ratios) and RH/LH print area ratios deficits. Treatment with indomethacin (1 mg/kg) or minocycline (50 mg/kg) had no effects on the weight bearing and print area ratios deficits of monoarthritic mice. However, combination of minocycline plus indomethacin restored weight bearing and paw print area ratios of monoarthritic mice similar to that observed in non-arthritic control mice.
Coadministration of indomethacin or a selective COX-2 inhibitor, CAY10404 with minocycline potentiates their effects and results in antinociception against thermal nociception, reduction of thermal hyperalgesia and alleviation of weight bearing deficits in monoarthritic mice at doses where either drug alone has no significant activity. Thus, the coadministration of lower doses of a NSAID or a selective COX-2 inhibitor plus minocycline could be useful in the management of inflammatory pain and arthritis.
Minocycline, a second-generation semisynthetic tetracycline antibiotic, has pleiotropic biologic activities besides its antimicrobial activities. Apart from its use as an antibiotic it is used in the management of various inflammatory diseases such as rheumatoid arthritis, periodontitis and several dermatological conditions [1]. In the management of rheumatoid arthritis minocycline is used as a disease-modifying antirheumatic drug (DMARD) and it alleviates joint tenderness and swelling among other features of the disease [2-5].
Recently, interest has arisen on its possible use in the management of pain. Research has been mostly on neuropathic pain where it has been shown that preemptive treatment with minocycline has protective effects but is ineffective once pain has developed [6,7]. It has also been reported to have antinociceptive effects in various models of inflammatory pain such as the formalin-induced nociception test and its antinociceptive effects have been suggested to be more of an anti-inflammatory nature rather than a centrally acting analgesic [8].
In this study the antinociceptive effects of co-administration of minocycline with a non-steroidal anti-inflammatory drug (NSAID), indomethacin, a selective inhibitor of COX-1, FR122047 or a selective COX-2 inhibitor, CAY10404, were evaluated in naïve mice and mice with lipopolysaccharide (LPS)-induced thermal hyperalgesia and monoarthritis. LPS is an endotoxin from gram-negative bacterial cell wall, which when administered intra-articularly into the ankle joint of a rodent limb can induce arthritis [9,10]. When the endotoxin is administered intraperitoneally it can cause generalized hyperalgesia. Various mechanisms are purported to be responsible for the LPS-induced hyperalgesia including the release and activation of pro-inflammatory cytokines and gelatinases, as well as glial cell activation [11-15]. Cytokines such as TNF-α and IL-1β cause the release of nociceptive mediators such as prostaglandins and sympathetic amines which lower the nociceptive threshold of sensory nerves [16-19]. Indomethacin is used in the treatment of various inflammatory diseases such as rheumatoid arthritis, osteoarthritis, gout, and ankylosing spondylitis [20-23]. NSAIDs are a heterogenous group of drugs commonly used in the management of inflammatory pain [24-27]. They produce their basic analgesic effect via inhibition of cyclooxygenase (COX) enzymes [25-27]. The analgesic effects of NSAIDs are also due to a number of mechanisms including a central mechanism involving both prostaglandin synthesis inhibition and probably changes in the endocannabinoid and monoaminergic system [28-32].
BALB/c (n = 338) and C57BL/6 (n = 32) mice (8 to 12 weeks old; 20 - 30 g) were used and were supplied by the breeding unit at the Health Sciences Center, Kuwait University, Kuwait, and were kept in temperature controlled (24 ± 1°C) rooms with food and water ad libitum. All experiments were performed during the same period of the day (8:00 AM to 4:00 PM) to exclude diurnal variations in pharmacological effects. The animals were handled in compliance with European Communities Council Directive 86/609 for the care of laboratory animals and ethical guidelines for research in experimental pain with conscious animals [33]. All procedures were approved by the Kuwait University Health Sciences Center animal care committee.
Minocycline and indomethacin (up to 10 mg/kg) (Sigma-Aldrich, St Louis, MO, USA) were dissolved in phosphate buffered saline (PBS). Indomethacin (≥ 20 mg/kg) (Sigma-Aldrich, USA)), selective COX-1 inhibitor, FR122047 [34,35] and selective COX-2 inhibitor, CAY10404 [36] (both from Cayman Chemical, Ann Arbor, MI, USA) were dissolved in peanut oil (Sigma-Aldrich, USA).
BALB/c or C57BL/6 mice were treated intraperitoneally (i.p.) with minocycline, indomethacin, FR122047, CAY10404 or their vehicles at a volume of 5 μl/g body mass. For the evaluation of coadministration, mice received two separate i.p. injections at the same time: minocycline + indomethacin, minocycline + FR122047, minocycline + CAY10404, minocycline + vehicle for indomethacin, minocycline + vehicle for FR122047, minocycline + vehicle for CAY10404, indomethacin + vehicle for minocycline, FR122047 + vehicle for minocycline or CAY10404 + vehicle for minocycline.
Thermal hyperalgesia was induced by administering LPS (Sigma-Aldrich, St Louis, MO, USA) at 1 mg/kg at a volume of 5 μl/g body mass. Reaction latency to the hot plate were measured before LPS administration and over a period of 1 month after LPS administration. Mice were treated intraperitoneally with drugs on the seventh day after LPS inoculation based on thermal hyperalgesia results (see Results section) and the effects of drug treatment on LPS-induced thermal hyperalgesia evaluated.
Reaction latencies to hot plate test were measured before (baseline latency) and at various times starting at 30 minutes after drug treatment. Briefly, mice were individually placed on a hot plate (Panlab SL, Barcelona, Spain) with the temperature adjusted to 55 ± 1 °C. The time to the first sign of nociception, paw licking, flinching or jump response to avoid the heat was recorded and the animal immediately removed from the hot plate. A cut-off period of 20 seconds was maintained to avoid damage to the paws.
Inflammatory monoarthritis was induced as described previously [9,10]. Briefly, mice were anaesthetized with halothane and LPS 10 μg in 20 μl PBS was injected intra-articularly into the right hind limb ankle joint through the Achilles tendon using a 30½-gauge needle. PBS (20 μl) was administered in the same way to the control group. The mice were made to cross the Catwalk walkway before LPS-inoculation and at 2 days post-LPS inoculation as described previously [10].
Mice were treated intraperitoneally with indomethacin 1 and 10 mg/kg, minocycline (50 mg/kg) alone, both drugs at the same time or their vehicles on the second day after LPS inoculation based on the weight bearing results [10]. The mice were then made to cross the Catwalk walkway at 1 hour post-drug treatment.
Paw pressure intensity and print areas of freely moving animals were measured using the Catwalk gait analysis system (Noldus Information Technology, The Netherlands) as described previously [10,37]. Briefly, the CatWalk instrument consists of an enclosed walkway with a glass plate, a high speed colour camera, and a recording and analysis software to assess the locomotor performance of rodent models. Each mouse was placed individually in the CatWalk walkway and allowed to walk freely and traverse from one side to the other of the walkway glass plate. The recordings were carried out when the room was completely dark, except for the light from the computer screen. Light from a fluorescent lamp was emitted inside the glass plate and completely internally reflected. Where the mouse paws made contact with the glass plate, light was reflected down and the illuminated contact areas recorded with a high speed colour video camera that was positioned underneath the glass plate connected to a computer that runs the CatWalk software 7.1. The software automatically labelled all the areas containing pixels above the set threshold (7 pixels). These areas were identified and assigned to the respective paws. Analysis of the recording generated a wide range of parameters of which only paw pressure (light intensity, which is the mean brightness of all pixels of the print at maximum paw contact, ranging from 0-255 arbitrary units) and paw print area (complete surface area contacted by the paw during a stance phase) were analysed.
The results in the text and figures are expressed as the means ± S.E.M. For the hot plate test percentage of change from baseline latency was calculated as follows: for naïve mice (response latency after drug treatment - baseline latency)/baseline latency × 100 and for mice with LPS-induced hyperalgesia (response latency after drug treatment - latency before drug treatment at 7 days post LPS inoculation)/latency before drug treatment at 7 days post LPS inoculation × 100. For the Catwalk gait analysis weight bearing was measured as the right hind (RH)/left hind (LH) limb ratio of the light intensity and the print area ratio was obtained from the RH/LH print areas. Percentage of change after drug treatment was calculated as follows: (light intensity or print area ratio after drug treatment - light intensity or print area ratio before drug treatment at 2 days post LPS inoculation)/light intensity or print area ratio before drug treatment at 2 days post LPS inoculation × 100. Statistical analyses were performed using two-way analysis of variance (ANOVA) followed by Bonferroni post-tests or one-way ANOVA followed by Newman-Keuls multiple comparison test. The differences were considered significant at p < 0.05.
The administration of indomethacin (5 to 50 mg/kg intraperitoneally) to naïve BALB/c mice did not result in a significant change in reaction latency compared to baseline latency in the hot plate at 55°C compared to vehicle treatment (Figure (Figure11 and Table Table1).1). The administration of minocycline 50 mg/kg (this dose has been used previously in other pain studies [6,8]) intraperitoneally to BALB/c mice produced a time dependent reduction in reaction latency in the hot plate at 55°C (Figure (Figure1).1). The reaction latency fell from a baseline latency of 12.66 ± 0.42 s to 8.31 ± 0.60 s at 1 hour post minocycline administration and by 2 hours it had returned to baseline reaction latency. The minocycline-induced reduction of reaction latency time from baseline value was dose dependent (Table (Table1).1). However, the coadministration of indomethacin 5 or 10 mg/kg and minocycline 50 mg/kg resulted in an increase in the reaction latency time compared to vehicle treated animals or indomethacin or minocycline alone (Figure (Figure11 and Table Table1).1). The effects of indomethacin 10 mg/kg, minocycline 50 mg/kg or coadministration of the two drugs on reaction latency was also tested in another mouse strain, C57BL/6, with similar results (Table (Table2).2). In order to determine the role of specific COX isoenzyme inhibition on this potentiated antinociceptive effects, minocycline was coadministered with selective COX inhibitors. The administration of a selective inhibitor of COX-1, FR122047 (10 mg/kg intraperitoneally) or a selective inhibitor of COX-2, CAY10404 (10 mg/kg intraperitoneally) to BALB/c did not result in a significant change in reaction latency compared to baseline latency in the hot plate or compared to vehicle treatment (Table (Table3).3). The coadministration of minocycline 50 mg/kg and FR122047 10 mg/kg did not significantly change the reduced reaction latency caused by minocycline (p > 0.05, Table Table3).3). However, the coadministration of minocycline 50 mg/kg and CAY10404 10 mg/kg resulted in a significant increase in reaction latency (p < 0.01) at 1 hour post treatment compared to vehicle or minocycline alone, respectively (Table (Table33).
Inflammatory hyperalgesia to thermal nociception was induced in BALB/c mice by a single i.p. administration of an endotoxin, lipopolysaccharide (LPS, 1 mg/kg), dissolved in PBS. A significant reduction in response latency time to thermal stimuli compared to the baseline latency in the hot plate test was observed in LPS-inoculated mice from 4 to 14 days post inoculation (Figure (Figure22).
Mice with LPS-induced hyperalgesia to thermal nociception at 7 days post inoculation (Figure (Figure3A)3A) were treated with indomethacin, minocycline or minocycline plus indomethacin coadminstration and their reaction latency to the hot plate recorded.
The administration of indomethacin (10 mg/kg) or minocycline (50 mg/kg) to mice with LPS-induced thermal hyperalgesia did not produce significant changes compared to vehicle treated mice. However, both drugs showed a tendency to have some antinociceptive activity at 1 hour post treatment (increased percentage change in reaction latency after treatment compared to before treatment) in mice with LPS-induced thermal hyperalgesia (Figure (Figure3B).3B). The effects of indomethacin or minocycline compared to vehicle treatment were 31.4 ± 10.9% and 43.2 ± 16.0% increase in reaction latency time after treatment with minocycline or indomethacin, respectively, compared to 2.1 ± 7.4% after vehicle treatment. Coadministration of minocycline 50 mg/kg plus indomethacin 10 mg/kg to mice with LPS-induced hyperalgesia resulted in antinociceptive activity (Figure (Figure3B).3B). The effects of the combination treatment compared to vehicle treatment were significant at 1 hour post treatment (61.9 ± 20.3% in reaction latency time after treatment with minocycline plus indomethacin compared to 2.1 ± 7.4% after vehicle treatment at 1 hour).
Recently we reported that the Catwalk gait analysis system can be used to objectively quantify weight bearing changes and evaluate pharmacological antinociception in freely moving mice with LPS-induced monoarthritis [10].
Weight bearing changes were calculated using the ratio of right hind (RH) limb to the left hind (LH) limb paw pressure intensity (light intensity). The ratio of RH/LH paw print area were also measured.
The RH/LH paw pressure ratio of the control group remained constant throughout the experiment, whereas those of LPS-inoculated mice decreased at 2 days after LPS administration compared to baseline or control mice (p < 0.01; Figure Figure4A)4A) similar to what has been described previously [10].
The changes observed in paw print area ratios in LPS inoculated mice compared to solvent-injected controls were similar to those observed in paw pressure ratios. The RH/LH print area ratio of the control group remained constant throughout the experiment, whereas those of LPS inoculated mice decreased at 2 days after LPS administration compared to baseline or control mice (p < 0.05; Figure Figure4B4B).
We observed that a higher dose of indomethacin (10 mg/kg) can alleviate the weight bearing deficits in mice with LPS-induced monoarthritis (data not shown) as previously described [10]. Treatment of mice with LPS-induced monoarthritis using either indomethacin 1 mg/kg or minocycline 50 mg/kg alone had no significant effect on the weight bearing or print area ratios deficits observed in these mice (Figure 4A,B). Mice with LPS-induced monoarthritis which were treated with the combination of minocycline 50 mg/kg plus indomethacin 1 mg/kg had less weight bearing deficits and their RH/LH paw pressure or print area ratios reverted to be similar to control animals, (no significant differences between control mice and those treated with the combination, Figure 4A,B). Coadministration of minocycline 50 mg/kg plus indomethacin 1 mg/kg to mice with LPS-induced monoarthritis significantly increased the RH/LH paw pressure or print area at 1 hour post treatment by 34.5 ± 12.3% and 85.8 ± 23.8% respectively, compared to drug vehicle treated monoarthritic animals which had -0.6 ± 10.1% and -5.4 ± 23.7% change at 1 hour post treatment for RH/LH paw pressure and print area respectively (Figure 4C,D). The effects of coadministration of minocycline plus indomethacin on RH/LH print area ratio was significantly higher than either indomethacin or minocycline treatment (Figure (Figure4D4D).
This is the first study to report enhanced antinociceptive activity and alleviation of weight bearing deficits by coadministering minocycline plus indomethacin, a NSAID, against thermal and arthritic nociception in mice.
The enhanced antinociceptive effects produced by coadministering minocycline plus indomethacin on inflammatory hyperalgesia and monoarthritis-induced weight bearing deficits could be useful in the management of inflammation and pain in patients with arthritis. Both drugs, minocycline and indomethacin, are used in the management of rheumatoid arthritis (RA) [1,5,21]. However, potentiation of each other's activities by the two compounds in alleviating pain and weight bearing deficits caused by inflammation or arthritis have not yet been reported. This potentiation of analgesic activity could have been missed in human RA because the interest on minocycline has been on its DMARD activity but not analgesic effects, moreover minocycline on its own even in our experimental setting does not have significant analgesic activity. It would be interesting to study in patients with arthritis whether co-administration of minocycline and indomethacin (or other NSAIDs) produce better analgesic activity than indomethacin or NSAIDs alone.
The LPS-induced hyperalgesia has been suggested to be due to the release and activation of pro-inflammatory cytokines and gelatinases, as well as glial cell activation [11-15]. Minocycline inhibits the synthesis and activity of gelatinases, the synthesis and release of cytokines as well a glial activation [7,38-42]. Thus some of the analgesic activities of minocycline observed in LPS-induced hyperalgesia but not in naïve animals could be due to its activities on cytokines, gelatinases and glial cells amongst other molecules and cells which are activated and involved in pain during inflammation.
We have previously observed that higher doses of indomethacin (10 mg/kg and above) resulted in even load distribution between the arthritic right hind limb and the non-arthritic left hind limb in mice with LPS-induced arthritis similar to control animals without monoarthritis, using the Catwalk gait analysis method [10]. In the current study a lower dose of indomethacin (1 mg/kg) or minocycline at 50 mg/kg alone could not reverse the weight bearing deficits caused by monoarthritis, however, coadministration of minocycline 50 mg/kg with indomethacin at 1 mg/kg alleviated the weight bearing deficits induced by monoarthritis. The observed ability to restore weight bearing deficits has relevance to arthritis since patients with unilateral knee osteoarthritis transfer weight load from the arthritic leg to the hip and knee of the uninvolved leg; and relieving pain in the affected knee, results in even load distribution between the legs [43,44].
Minocycline has anti-inflammatory activities and is used as a disease modifying antirheumatic drug. It has been reported to inhibit T cell activation, gletanisases and other matrix proteases activity and cytokine production in rheumatoid arthritis, thus reducing inflammation [45-48]. On the other hand indomethacin is purported to produce analgesia and anti-inflammatory activity through the inhibition of cycloxygenase and prostaglandin synthesis [21,49]. Since these drugs affect different targets, all involved in inflammation and pain during arthritis, coadministration could result in an enhancement of each other's activity and be more effective at lower doses.
Other possible reasons for the enhanced antinociceptive activity by coadministering minocycline and indomethacin could have been due to the inhibition of COX enzyme activity by indomethacin and inhibition of 5-lipoxygenase activity by minocycline. The inhibition of COX-2 isoenzyme seems to be important for this synergism since coadministration of minocycline with CAY10404, a selective inhibitor of COX-2 [36] but not FR122047, a selective inhibitor of COX-1 [34,35], produced antinociceptive activity. Minocycline has been reported to block 5-lipoxygenase activation [50]. Recently, administration of a 5-lipoxygenase inhibitor has been reported to potentiate the antinociceptive activity of NSAIDs [51]. Thus, the 5-lipoxygenase inhibitory activity of minocycline could potentiate the activity of the NSAID, indomethacin. The other possible reason for the synergism on antinociception could be that the two drugs synergistically alter the endocannabinoid system in the central nervous system (CNS). Minocycline and indomethacin can both independently alter endocannabinoid levels or activity in the CNS and this has been linked to their antinociceptive activity [52,53]. Endocannabinoids have anti-inflammatory activities, antinociceptive activities and can reduce thermal hyperlagesia in rodents [54-56]. Possible biochemical pathways involved in minocycline and indomethacin enhancement of each other's antinociceptive activity warrants further research.
Using mice models of inflammation-induced thermal hyperalgesia and monoarthritis we show that coadministration of minocycline with indomethacin or a selective COX-2 inhibitor, CAY10404 potentiates their effects and results in antinociception against thermal nociception, reduction of thermal hyperalgesia and alleviation of weight bearing deficits in arthritic mice at doses where either drug alone has no significant activity. Thus, the combination of lower doses of a NSAID plus minocycline could be useful in the management of inflammatory pain and arthritis with less dose-dependent side effects.
ANOVA: analysis of variance; CNS: central nervous system; i.p: intraperitoneally; LH: left hind limb; LPS: lipopolysaccharide; NSAID: non-steroidal anti-inflammatory drug; PBS: phosphate buffered saline; RH: right hind limb; S.E.M: standard error of the mean
The authors declare that they have no competing interests.
AAA participated in the acquisition and analysis of data, and helped to edit the manuscript. WM participated in the design of the study, acquisition and analysis of data, and drafting and preparation of the manuscript. Both authors read and approved the final manuscript
Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923 Safat, 13110 Kuwait
The pre-publication history for this paper can be accessed here:
This study was supported by a grant from Kuwait University Research Administration (PT01/08). We are grateful to Dr Subramanian S Parvathy from the Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, for her support and technical assistance.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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#Awesome | Marvel | Lord of the Rings | Harry Potter | Lego
Awesome stuff I like! From Harry Potter to Superheros to Lego and everything in between.
56 Pins867 Follower
Inspirational Superhero Quotes - 9GAG
Harry Potter / Lord of The Rings mash. I have not seen Lord of the rings but I thought this was pretty funny!
The Lord of the Rings Infographic | Course Hero
I am a servant of the Secret Fire, wielder of the flame of Anor. The dark fire will not avail you, flame of Udûn. Go back to the Shadow.
Turtle Island - shipwreck tavern by qi-tah on Flickr
LEGO master recreates Lord of the Rings Battle of Helm's Deep with 150,000 bricks.
You think your movie scene is epic? Think again old chap, terribly sorry to prove you wrong.
Mekorig's mine. Wonderful! Blue wizard hat as water flow made me smile.
Harry Potter: Diagon Alley Posters - Created by The Green Dragon Inn
Dr. Seuss Sign

subset: commoncrawl


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Cloud strife
Retro 2 New. Keeping up with ALL things game related. More
Cloud Strife
Cloud Strife <3 I love him so much
Cloud Strife
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Cloud Strife - Characters & Art - Dissidia: Final Fantasy
Um, sometimes I reminisce on when I use to play Square Enix RPGs all the time. I still have fond memories of all those huggable spikey-haired blonde guys.
I really like how Cloud looks in this picture. I love the emo and the adorkable as much as anyone, but there isn't enough fanart of fakepersonality!Cloud.
Cloud Strife - The Final Fantasy Wiki has more Final Fantasy information than Cid could research
Every nerd board needs Final Fantasy love. Cloud Strife<3
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Cloud Strife. Fan art. Final Fantasy VII.
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Upated on :February 26, 2014
Original Title: Chera in telefon zang nemizanad?
Director: Hadi Yaghinlou
Writer & Animator: Hadi Yaghinlou
Sound & Music: Mahmoud Mohaghegh
Concept Design & Texture Artist: Mani Kashian
2D Compositing & Animation: Souroush Dianati
Director's Assistant: Mani Kashian
Director's Advisor: Mohammad-Ali Soleymanzadeh
Scriptwriter Advisor: Vajiyollah Fardemoghadam
Production Company: KANOON (Institute for the Intellectual
Development of Children & Young Adults)
2013, 3D Animation, HD, Color, Stereo, No dialogue, Ratio (16:9), 8min.20sec.
In a corner of an old workshop, a repairman is lost in the quiet world of telephones until his calmness is disturbed with continues rings. Fed up with the rings, he starts checking numerous phones to find the ringing one to answer. In his search he gets out of the workshop and all of sudden finds himself in mysterious places. He passes through an endless land of unknown telephones until he sees nothing around him. At this moment the faces the truth. The voice is from inside him.
- 6th Iranian Film Festival San Francisco, 28-29 Sep., 2013, USA (Animation Section)
- Jana International Film Festival for Children & Youth, Oct., 2013, Lebanon
- 30th Tehran International Short Film Festival, 14-22 Oct., 2013, Iran (Best Animation Section)
- 12th International "Gold Panda" Awards for Animation of Sichuan TV Festival, 16-18 Nov., 2013, China ( Official Selection Prize- Animated Short Films)
- 1st Chennai International Short Film Festival, 20-23 Feb., 2014, India (Short Animation Competition)
v "Sepanta Award" for Best Animation, 6th Iranian Film Festival San Francisco, USA, 2013
v Trophy Award and Cash Prize (50000000 Rials) for Best Animation, 30th Tehran International Short Film Festival, Iran, 2013


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HOME > Big Brother > Big Brother 4
Big Brother 4
Eleven former 'Big Brother' houseguests to guest star on CBS's 'Yes, Dear,' on Monday, October 20
CBS has released the full roster of former Big Brother contestants, as well as an episode airdate, for their previously announced special Big Brother-themed episode of the network's Yes, Dear, Monday night comedy. Airing on Monday, October 20 at 8PM ET, the Yes, Dear, episode will see Jimmy (played by Mike O'Malley) disqualified as contestant from the "Big Brother" house as a result of Gregs (Anthony Clark) shenanigans. Full Story
Former 'Big Brother' contestants to appear on CBS's 'Yes, Dear'
Daily Variety (subscription required) reports that several contestants from past seasons of CBS's Big Brother will appear on an upcoming episode of the network's Monday-night comedy Yes, Dear.
Big Brother 4 - Finale Episode summary
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Big Brother 4 - Week 11 Episode 3 summary
Our episode summary for Episode 3 (Friday) of Week 11 of CBS's Big Brother 4, entitled "The Recrap from H-E-Double Hockey Sticks" and written by strid333, has been posted. Check it out by clicking here.
Is CBS deliberately skewing 'Big Brother 4' to make final 2 look less offensive?
Protecting its franchise? Or protecting its ratings? One of those appears to be what CBS is trying to do in its careful editing of its weekly broadcasts of Big Brother 4, as it hides the bigoted and offensive comments by the final two contestants from the mass TV audience.
Big Brother 4 - Week 11 Episode 2 summary
Our episode summary for Episode 2 (Wednesday) of Week 11 of CBS's Big Brother 4, entitled "Why Can't Julie Just Shut Up?" and written by strid333, has been posted. Check it out by clicking here.
Record 'Big Brother 4' audience watches Robert Roman be booted from the Final 3
The Big Brother 4 house is down to its final two houseguests following last night's eviction of Robert, which was witnessed by a record audience of 11 million viewers, according to final Nielsen ratings for Wednesday, Sept. 17.
Robert Roman becomes tenth houseguest to be evicted from the 'Big Brother 4' house
After winning the third leg of the three-part Head of Household competition, Alison Irwin chose to evict the last member of the Dream Team, Robert Roman, from the Big Brother 4 house, bringing Jun Song to the finals with her.
Big Brother 4 - Week 11 Episode 1 summary
Our episode summary for Episode 1 (Tuesday) of Week 11 of CBS's Big Brother 4, entitled "A Mime Is a Terrible Thing to Waste" and written by strid333, has been posted. Check it out by clicking here.
Big Brother 4 - Week 10 summary
"Jun's tiny bikini will blind us all!" is the title given by Canada Girl to our episode summary for Week 10 of CBS's Big Brother 4. Check it out (the summary, not Jun's tiny bikini) by clicking here.
Racism and anger fill Net feeds from U.S. 'Big Brother 4' house
Jam! Showbiz reports that two of the three finalists in CBS's 'Big Brother 4' spent much of their time during Monday night's live Internet broadcast making racist comments about the third contestant and insulting his young daughter, leading many viewers of the show to protest that one of the two is likely to emerge from the house as the victor.
Wednesday's 'Big Brother 4' episode wins Adults 18-49 demo, draws over 10 million viewers
According to the final Nielsen ratings for the evening of September 10, CBS's "Big Brother 4 Wednesday" was the night's highest rated program in adults 18-49 and adults 25-54. The live broadcast, which saw the eviction of pilates instructor Erika Landin, matched its second largest audience of the summer.
CBS announces remaining 'Big Brother 4' broadcast schedule
As host Julie Chen mentioned last evening, with the final Head of Household competition underway and the "Big Brother 4" household down to only three houseguests, the "Big Brother 4" broadcast schedule will be changing slightly -- starting with the preemption of the Friday, September 12 show.
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- USDA organic
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- Oven safe to 450 degrees
- The nonstick cookie sheet can be used on its own as a baking pan
- 5 high quality lullabies and sounds
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- 60mm 18 shatterproof ornaments
- 4 shiny with glitter decor pumpkin pieces
- Accent chair has a brown/red/oblong pattern with woven fabric and dark brown legs
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ALL >> Business >> View Article
Important Faqs On Manholes From A Reputable Manhole Cover Manufacturer In Kolkata
Total Articles: 9
Manholes are essential parts of civil drainage pipes. Most of the streets around us have manholes over them. If you have seen them carefully before, you must have observed that the manhole covers are basically made of cast iron. Choosing this metal for making manhole covers is relevant, as cast iron is strong and durable. It can take the load of heavy traffic for long years. At the same time, cast iron does not easily get rust like other untreated iron products. However, for many people, manholes and manhole covers are simple structures. If you belong to that group, you would be amazed to know that a huge engineering concept is integrated in this simple cast iron structure.
Here are some frequently asked questions and answers on the manholes and manhole covers that would help you knowing more about the same.
Why are most of the manholes made of cast iron? Is ductile iron manhole cover better than cast iron cover?
Most of the manholes are made of cast iron traditionally. For an easy and smooth maintenance of the pipe work, manhole covers are needed to be opened as and when required. Thus, it offers adequate safety to the workers when they carry out the lifting up process. On the other hand, it is safe for the normal pedestrians too, as the metal is much heavier. However, engineers prefer using ductile iron to cast iron, because of its manifold utilities. Primarily, ductile iron is far lighter when compared to cast iron. It does not stuck or jams like cast iron occasionally. On the other hand, in spite of its low self-weight, ductile iron is able to tolerate heavy load. Additionally, ductile iron is less fragile compared to cast iron, which tends to rupture due to rust over time. Finally, cost of ductile iron is less compared to cast iron. That is why ductile iron is preferred nowadays for manufacturing manhole covers.
Why do manholes explode sometimes?
Manhole explosion is not a regular occurrence, but it happens at times beyond control. Moreover, when it happens it takes away many lives. Pedestrians on roads and workers inside the manhole can be seriously injured or died due to poisonous gas. Generally, manhole covers have provisions with which they can release energy from inside. Manhole explosions normally occur due to combustion and ignition of flammable gas. This gas can generate due to leakage of any nearby gas line. Sometimes, over production of methane gas can be a reason of manhole explosion too. On the other hand, it can happen due to degradation of cable insulation too.
How to choose a manhole manufacturer?
Manhole explosion can be avoided by implementing advanced manhole designs. Nowadays, unharmed designs are available for building new manhole lines. One should always try to find out a reliable manhole cover manufacturer in Kolkata so as to avoid any possible accident or danger. Cast iron manhole covers too work great if they are good in quality. To ensure this, one has to look for a dependable cast iron manhole cover exporter in Kolkata.
About Author: Arun Mitra is an expert consultant provides help to the industries to get most beneficial Manhole Cover from the top Manhole Cover Manufacturer in Kolkata. He has huge information in this regards. Consult with him instantly when you require professionals help in this regards.
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text: This listing is no longer available or has been sold. Find Another One Others Looked At... New in Box SELLER: Discount Tactical Supply 1 $299.99 Leupold VX-3i 3.5-10x40mm Riflescope - N... SELLER: Discount Tactical Supply 1 $519.99 ATN X-Sight II HD 5-20x Day and Night Ri... SELLER: Discount Tactical Supply 1 $699.00 Nikon P-308 4-16x42 SF Matte BDC 800 Rif... SELLER: Discount Tactical Supply 1 $449.95 Leupold Mark AR 3-9x40mm Matte Duplex SELLER: CintiGun4Fun 0 $330.00 Burris Scout Riflescope 2-7x32mm - New i... SELLER: Discount Tactical Supply 1 $399.00 Non Guns Scopes Mounts Rings Optics Rifle Scopes Variable Focal Length BURRIS FFII . X BALLPLEX MATT | 1110 | 0 | Lc | 437.4948ms BURRIS FFII 4.5-14X42 BALLPLEX MATT For Sale from B&W | Positive feedback: 97% View | Verified Seller | 410 Completed Sales View Sellers Items This item is no longer available. /UserImages/114276/998242801 9368316.jpg /UserImages/114276/998242801 9368317.jpg Description: Burris, Fullfield II, Scope, 4.5-14X42, Ballistic Plex, Matte, 0.25MOA UPC Code: 000381001832 Manufacturer: Burris Manufacturer Part #: 200183 Model: Fullfield II Type: Rifle Scope Power: 4.5-14X Objective: 42 Reticle: Ballistic Plex Finish/Color: Matte MOA: 0.25MOA Read More Condition: New In Box Location: MI Trades Accepted: no Read More Shipping Notes: ups Read More Share Item Item #: 998242801 Stock No.: 200183 B&W Seller Since: Nov. 2009 Seller Level: Trusted Seller This seller is an FFL City: Clinton Twp State: MI This item is no longer available. Price: This Seller Accepts Online Payment Shipping: $15.00 (or Arrange local transfer) Accepted Payment Methods: Returns: No Returns Your Recently Viewed Items


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How much would a mechanic charge for replacing the rear coil pack and spark plug on a 2002 Nissan Maxima?
I have a 2002 Maxima and the number 3 plug and coil pack need to be replaced. Since it requires removal of the manifold I was wondering how much this repair will cost.
1 Answer
Figure the price of the coil pack plus a couple hours of labor. Really depends on who does it. I'd say $200-300
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Making sure to give her proper oral, the superb woman then turns around and presents her ass for a anal doggie style session. 50 Pincho de gambas y mangoA barbecued skewer of prawns, fresh mango and peppers marinated in guava, ginger, honey, lime juice and spices ??5. Skills Development Not only are our instructors great climbers, they have a well deserved reputation as coaches too.
This information is only used for the sole purpose of completing your request or for whatever reason it may have been provided. Luckily I've only done it twice, and both times my son got away very lightly (only vomited once each time) I'm convinced this is because of the antibodies I was giving him through my milk. The Garden History History of Garden Staff WWI Centenary 2014 Plant Collections World Woodland Garden Wildlife Index Seminum Microclimate Data Florilegium Society London's Secret Garden Growing Friends Visit Opening times Tickets &.
Loyalty benefits Get exclusive offers, earn points to redeem for discounts, news and previews (see conditions). 1 order: 510 calories, 3g saturated fat, 1,496mg sodium, 16g carbsSkinnylicious French Country SaladMixed Greens, Grilled Asparagus, Fresh Beets, Goat Cheese, Candied Pecans and Vinaigrette. They stood and watched and didn't interfere as the protest continued on Piccadilly, on then Regent St.


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Question about Computers & Internet
My son installed yahoo messenger. The program starts on my screen and his friends keep trying to talk to me. I tried to delete it, but it says I need permission. I am listed as an administrator. I read that I had to transfer ownership and I tried that also without results. My son tried to delete it and even withdrew his name and password from yahoo but it's still there greeeting me. I'm ok with him having messenger if it's only on his screen.
Posted by dmchugh110 on
I am able to see the "add/remove" section in control panel. I click on it and it says I need permission to remove it. I am the owner of the computer and the administrator. I don't know who's permission the program is asking for.
are u able to see the programme in "add/remove" section under control panel?
All you have to go to is CONTROL PANEL THEN TO ADD/REMOVE PROGRAMS. on there it should say yahoo messanger. click on it and press remove and restart your c.p.u. then the yahoo instant messanger will be gone
Posted on Dec 03, 2008
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Posted on Jan 02, 2017
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The Donald Trump administration waived nuclear-related sanctions on Iran today in accordance with the landmark nuclear deal while ripping the country over its ballistic missile program and human rights record. According to media reports, Fractur engaged in the sale and delivery of explosives to the Syrian government.
"This administration is committed to countering Iran's destabilizing behavior, such as Iran's development of ballistic missiles and support to the Assad regime", Treasury Secretary Steven Mnuchin said in a statement later on Wednesday.
That was a relief to Mr Rouhani, who made the 2015 nuclear deal the centrepiece of his efforts to end Iran's isolation and rebuild its economy with foreign investment.
It is noted that the sanctions imposed against officials Morteza Fracture and Rahim Ahmadi.
The decision not to renew sanctions came just two days before Iran votes and may prove a boost for President Hassan Rouhani, who approved the nuclear deal and is seeking re-election.
Unnamed officials earlier told Reuters earlier that Washington had already noted Iranian officials that the waivers would remain in place.
After accusing Iran of "not living up to the spirit" of the deal, the new Republican president said in April that his administration was analyzing the JCPOA and would "have something to say about it in the not-too-distant future".
Laptop ban in Europe could cost airline passengers $1 billion
The International Air Transport Association, or IATA, which represents 265 airlines, wrote to both the European Union and the U.S. With the USA pushing to expand the ban, and other groups suggesting it should be rolled back, we may be at a tipping point.
Under the 2015 deal, the US and other world powers eased sanctions after the U.N.'s International Atomic Energy Agency confirmed that Iran had taken a series of steps to pull its nuclear program back from the brink of weapons capability.
In retaliation for the new USA sanctions, Iran said it had added nine American individuals and companies to its own list of 15 US companies for alleged human rights violations and cooperation with Israel, its archenemy.
On Thursday, Iran blasted the new bans and said it would retaliate by adding nine US individuals and corporations to its own sanctions list over human rights violations within the United States.
Mark Dubowitz, chief executive of the Foundation for Defence of Democracies non-profit policy group and an opponent of the Iran nuclear deal, argued that the Trump administration was pursuing a "waive and slap" approach that temporarily suspends some sanctions while imposing others.
Separately, the State Department said it might add new sanctions targeting Iran's human rights abuses, which also are not covered under the nuclear deal, also known as the Joint Comprehensive Plan of Action.
The sanctions block any assets the individuals or companies may have in the USA and bars Americans and non-Americans from doing business with them.
The sanctions imposed on Iran for its ballistic missile program have targeted senior Iranian military officials in addition to an Iranian company and a network based in China that stands accused of supplying Iran with the wherewithal sufficient to produce ballistic missiles, said the US State Department.
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All About Friends ~ Sitcom
This application doesn't need any description for explanation as it is all about the one of the most popular sitcoms of all time "FRIENDS".
This application provides information about the introduction, cast, characters, seasons and corresponding episodes of this popular sitcom.
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STARmeterSEE RANK
Down 819 this week
Neil Gaiman
Neil Gaiman was born on November 10, 1960 in Portchester, England as Neil R. Gaiman. He is a writer and producer, known for Princess Mononoke (1997), Stardust (2007) and Coraline (2009). He has been married to Amanda Palmer since November 10, 2010. They have one child. He was previously married to Mary T. McGrath. See full bio »
Born:in Portchester, England, UK
More at IMDbPro » Contact Info: View agent


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Donald Martiny - Installation View
ModernDallas.net re-post of my article
Although it is on the outer edge of the Design District, I always find time to head over to Galleri Urbane to take a peek. Up for less than a week, their current show of color and marks comes together in two solo shows by Jessica Snow and Donald Martiny.
Jessica Snow is working in familiar territory. Several current artists come to mind that are working in a similar vein as Snow. For example, "Amplitude III," with the dripped down effects and the overlapping lines gave me a vague recollection of Dion Johnson's paintings. "Dot...Dot...Dot…" seems to allude to Damien Hirst's dots series. Snow manages to distinguish her work with slight irregular shapes that make the work less machine age and a little more human. Snow brings an informal quality that feels more fun than stuffy. I am reminded of Peter Davies' 1997 "The Hot One Hundred" painting when I look at Snow "Color Stack." I don't believe Snow is concerned with the unattainable goal of being solely original. I believe she is more interested in further developing the investigation in color and simple shapes.
Donald Martiny's sculptural paintings help to further lay waste to the idea that the impromptu mark making is the purest form of expression. His forms are giant simulated gesture marks of the brush. I am reminded of Roy Lichtenstein's large illustrated brush stroke sculptures. Lichtenstein was of course critiquing the automatic painting styles of the Abstract Expressionist. Martiny further extends this conversation through his own images. In line with the AbEx artists, most together seemed to imply a larger work. Breaking the rectangle and letting the stimulated paint stroke hang free from a frame also critiques the limits many artists allow in their work. Martiny uses just one color in each work, which leaves a clean look that does not detract from the gesture mark. I am rarely a fan of the impasto style, but Donald Martiny makes it easy to make an exception.
Jim and Mary Lynn are glass artists. They were in the process of rebuilding their equipment, so we didn't get to see anything blown, but they were a pleasure to meet. The objects impressed my travel companions in the back of the bus so much, they took some pieces home. We left the compound for our last stop at Photographs Do Not Bend Gallery.
Better known as PDNB, we sat down to some Central Market sandwiches, fruit, and wine. The gallery's main show was William Eggleston and artists in his circle and other artists influenced by his color photography. Back when everyone was using black and white, because it was so much "more artistic," William Eggleston and some contemporaries in the South started to prove that color photography had as much merit as black and white. Anyone lacking a bit in photography history could still appreciate Eggleston's photos, because of the context created from PDNB curation of the show.
Snow's work was flat and colorful, while Martiny's was like cake frosting with eye contrast. And as always, the back room is filled with a collection of their other artists. The shows come down October 7th.
ModernDallas.net for more images.


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Buda Castle (Hungarian: Budavári Palota, German: Burgpalast, Turkish: Budin Kalesi) is the historical castle and palace complex of the Hungarian kings in Budapest, and was first completed in 1265. In the past, it has been called Royal Palace (Hungarian: Királyi-palota) and Royal Castle (Hungarian: Királyi Vár, German: Königliche Burg). Buda Castle was built on the southern tip of Castle Hill, bounded on the north by what is known as the Castle District (Várnegyed), which is famous for its Medieval, Baroque, and 19th-century houses, churches, and public buildings. It is linked to Clark Ádám Square and the Széchenyi Chain Bridge by the Castle Hill Funicular. The castle is a part of the Budapest World Heritage Site, which was declared a Heritage Site in 1987.
The first royal residence on the Castle Hill was built by King Béla IV of Hungary between 1247 and 1265. It is uncertain whether it was situated on the southern tip of the hill or on the northern elevation, near the Kammerhof. The oldest part of the present-day palace was built in the 14th century by Stephen, Duke of Slavonia, who was the younger brother of King Louis I of Hungary. Only the foundations remain of the castle keep, which was known as Stephen's Tower (Hungarian: István-torony). The Gothic palace of King Louis I was arranged around a narrow courtyard next to the keep. King Sigismund significantly enlarged the palace and strengthened its fortifications. Sigismund, as a Holy Roman Emperor, needed a magnificent royal residence to express his prominence among the rulers of Europe. He chose Buda Castle as his main residence, and during his long reign it became probably the largest Gothic palace of the late Middle Ages. Buda was an important artistic centre of the International Gothic style. Construction began in the 1410s and was largely finished in the 1420s, although some minor works continued until the death of the king in 1437. The palace was first mentioned in 1437, under the name "fricz palotha". The most important part of Sigismund's palace was the northern wing, known as the Fresh Palace (Hun: Friss-palota). On the top floor was a large hall called the Roman Hall (70×20 m or 230×66 ft) with a carved wooden ceiling. Great windows and balconies faced toward the city of Buda. The façade of the palace was decorated with statues, a and coat-of-arms. In front stood the bronze equestrian statue of Sigismund, later repaired by King Matthias Corvinus. The southern part of the royal residency was surrounded with narrow zwingers. Two parallel walls, the so-called "cortina walls", run down from the palace to the River Danube across the steep hillside. The most imposing structure, the Broken Tower (Hun: Csonka-torony), on the western side of the cour d'honneur, remained unfinished. The basement of the tower was used as a dungeon; the top floors were probably the treasury of the royal jewels. The last phase of large-scale building activity took place under King Matthias Corvinus. During the first decades of his reign the king finished the work on the Gothic palace. The Royal Chapel, with the surviving Lower Church, was likely built at that time. After the marriage of Matthias and Beatrice of Naples in 1476, Italian humanists, artists, and craftsmen arrived at Buda. The Hungarian capital became the first centre of Renaissance north of the Alps. The king rebuilt the palace in an early Renaissance style. The cour d'honneur was modernized and an Italian loggia was added. Inside the palace were two rooms with golden ceilings: the Bibliotheca Corviniana and a passage with the frescoes of the twelve signs of the Zodiac. The façade of the palace was decorated with statues of John Hunyadi, László Hunyadi, and King Matthias. In the middle of the court there was a fountain with a statue of Pallas Athene. Only fragments remain of this Renaissance palace: some red marble balustrades, lintels, and decorative glazed tiles from stoves and floors.
The reconstructed medieval fortifications and the Great Rondella In the last years of his reign Matthias Corvinus started construction of a new Renaissance palace on the eastern side of the Sigismund Courtyard, next to the Fresh Palace. The Matthias Palace remained unfinished because of the king's early death. The palace had a monumental red marble stairway in front of the façade. Matthias Corvinus was usually identified with Hercules by the humanists of his court; the bronze gates were decorated with panels depicting the deeds of Hercules, and a great bronze statue of the Greek hero welcomed the guests in the forecourt of the palace complex, where jousts were held. The walled gardens of the palace were laid out on the western slopes of the Castle Hill. In the middle of the enclosure, a Renaissance villa was built by Matthias. Only one column survives of this so-called Aula Marmorea. After the death of Matthias Corvinus, his successor, King Vladislaus II, carried on the works of the Matthias Palace, especially after his marriage with Anna of Foix-Candale in 1502. Under the reign of King John Zápolya (the last national ruler of Hungary) the palace was repaired. On the southern tip of the Castle Hill, the Great Rondella was built by Italian military engineers. The circular bastion is one of the main surviving structure of the old palace.
After the Battle of Mohács, the medieval Kingdom of Hungary collapsed. The Ottoman Turks occupied the evacuated town on 11 September 1526. Although Buda was sacked and burned, the Royal Palace was not damaged. Sultan Suleiman the Magnificent carried away all the bronze statues (the Hunyadis, Pallas Athene, and Hercules) with him to Constantinople. The statues were destroyed there in a rebellion a few years later. The Sultan also took many volumes from the Corvina library. In 1529 the Ottoman army besieged and occupied Buda again, and the palace was badly damaged. On 29 August 1541 Buda was occupied again by the Ottomans, without any resistance. Buda became part of Ottoman Empire and the seat of the Eyalet of Budin. Although Turkish travel writers wrote enthusiastically about the beauty of the palace of the Hungarian kings, the new Ottoman government let the palace decay. It was partially used as barracks, a storage place, and stables, and otherwise it stood empty. The palace was called Iç Kala ("Inner Castle") and Hisar Peçe ("Citadel") by the Turks. The name of the cour d'honneur was "Seray meydani". The favourite nickname of the complex was "Palace of the Golden Apples". In the era between 1541 and 1686, the Habsburgs tried to re-capture Buda several times. Unsuccessful sieges in 1542, 1598, 1603, and 1684 caused serious damage. The Ottoman authorities repaired only the fortifications. According to 17th-century sources, many buildings of the former Royal Palace were roofless and their vaults collapsed. Nonetheless the medieval palace mostly survived until the great siege of 1686.
The medieval palace was destroyed in the great siege of 1686 when Buda was captured by allied Christian forces. In a heavy artillery bombardment, many buildings burned and collapsed. The Stephen's Tower, used as a gunpowder store by the Ottomans, exploded when hit by a single cannon, said to have been fired by a friar called Gábor, also referred as Tüzes Gábor ("Gabriel Fiery"). According to contemporary sources, the explosion killed as many as 1,500 Turkish soldiers and caused a tidal wave on the Danube that washed away artillery batteries and guards standing on the opposite shore.[citation needed] Habsburg military engineers made several plans and drawings of the buildings in subsequent decades. Although the walls mainly survived, the burned-out shell rapidly decayed from a lack of maintenance. Between 1702 and 1715, Stephen's Tower disappeared completely, and the palace was beyond repair. In 1715, King Charles III ordered the demolition of the ruins. Johann Hölbling surveyed the still-existing structures. The king ordered the surviving marble statues, antiquities, inscriptions, and coins should be spared (there is no evidence about the realization of the royal decree). The main part of the palace and the Broken Tower were totally demolished, the hollows and moats were filled, and a new flat terrace was established. The southern fortifications, zwingers, and rooms were buried under tons of rubbish and earth.
In 1715 a small Baroque palace was built according to the plans of Johann Hölbling. It was a simple rectangular building, with an inner court and a shorter side wing, which was later demolished. The Hölbling palace is identical with the core of the present-day palace, where the Baroque Court of the Budapest Historical Museum is now located. The interior of the palace was left unfinished when work stopped in 1719. The Hofkriegsrat commissioned Fortunato di Prati to make several plans for the palace, but lack of money hindered their implementation. In 1723 the palace was accidentally burned down, and the windows were walled up in order to stop further deterioration. Several drawings from the 1730s and 1740s show the unfinished decaying shell of the simple two-storey blockhouse. Some engravings show an idealized finished version which never existed. Sometime around 1730 the roof was repaired.


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|December 20, 2012 11:54 AM EST
Online university recognized in annual guide for best educational options for active-duty service members, veterans, military spouses, and dependents
SALT LAKE CITY, Dec. 20, 2012 /PRNewswire-USNewswire/ -- Western Governors University (WGU), www.wgu.edu, has been included in the 2013 Guide to Military-Friendly Colleges & Universities by Military Advanced Education for the sixth consecutive year. Initiated in 2008, the annual guide recognizes institutions that provide the best educational options and fit for military service members, veterans, and their families.
Nonprofit and online, WGU was selected as a military-friendly school based on factors of particular interest to service members such as academic support and quality, flexibility, accessibility, and financial assistance. WGU's competency-based learning model lets students complete program requirements based on their prior work experience and academic knowledge, allowing them to accelerate through things they already know so they can focus on what they still need to learn.
WGU's programs are highly portable and easily accessible; students can access coursework and learning resources 24/7 from anywhere with an Internet connection. Airman 1st Class Ben Engel of the Air National Guard is a WGU student earning a bachelor's degree in marketing management. He says that at a traditional brick-and-mortar school there isn't much flexibility and it's common for service members to have to drop classes mid-semester for work or other priorities. "With WGU I don't have to worry—life can change at a moment's notice and I don't have to stress about it. If I get deployed, or have to travel, or go on a training mission, I can get online and work on my courses no matter where I am," Engel said. In addition to accessibility, all students are supported by one-on-one mentors through their entire degree program.
As a military-friendly institution, WGU is an affordable option for military families. Tuition for most programs is about $6,000 per year. Students who can devote additional time to their studies can accelerate their program, saving both time and money. WGU's online degree programs are approved for tuition assistance for active-duty, reserve, and National Guard personnel. Veterans are eligible for education benefits through the G.I. Bill. Because of WGU's modest tuition, veterans will generally be eligible for benefits that more than cover the full cost of tuition, fees, and books. Additionally, WGU offers several scholarships specifically for active-duty personnel, reservists, veterans, and military spouses.
WGU offers 55 accredited online bachelor's and master's degree programs in the fields of business, information technology, teacher education, and health professions, including nursing. Terms are six months long and can begin on the first day of any month.
For more information about WGU and military or veterans' benefits, please visit www.wgu.edu/military.
About Western Governors University
Featured on NPR's "All Things Considered," The NBC Nightly News with Brian Williams, CNN's "Schools of Thought," and in The New York Times, WGU is the only university in the U.S. offering accredited, competency-based bachelor's and master's degree programs. WGU is accredited by the Northwest Commission on Colleges and Universities. WGU's Teachers College is the first and only exclusively online provider of teacher education to receive accreditation for its teacher licensure programs from NCATE, the National Council for the Accreditation of Teacher Education. The WGU bachelor's and master's nursing degree programs have been accredited by the Commission for Collegiate Nursing Education (CCNE), and its B.S. in Health Informatics is accredited by CAHIIM (Commission on Accreditation for Health Informatics and Information Management Education).
On June 11, 2010, WGU Indiana was created by Governor Mitch Daniels as Indiana's eighth state university. WGU Washington was established by the Washington State Legislature on April 22, 2011. On August 3, 2011, the state of Texas created WGU Texas. WGU Indiana, WGU Washington, and WGU Texas are state-endorsed and offer degree programs that are accredited through Western Governors University.
The university has earned the support of more than 20 leading corporations and foundations. They include institutions such as AT&T, Bill & Melinda Gates Foundation, Lilly Endowment, HCA, Hewlett-Packard, Lumina Foundation, Microsoft, Oracle, SunGard Higher Education, and Zions Bank. More information is available at www.wgu.edu or by calling 866.225.5948.
Follow WGU:
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SOURCE Western Governors University
In his keynote at @ThingsExpo, Chris Matthieu, Director of IoT Engineering at Citrix and co-founder and CTO of Octoblu, focused on building an IoT platform and company. He provided a behind-the-scenes look at Octoblu's platform, business, and pivots along the way (including the Citrix acquisition of Octoblu).
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SYS-CON Events announced today that A&I Solutions has been named "Bronze Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Founded in 1999, A&I Solutions is a leading information technology (IT) software and services provider focusing on best-in-class enterprise solutions. By partnering with industry leaders in technology, A&I assures customers high performance levels across all IT environments including: mai...
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SYS-CON Events announced today that delaPlex will exhibit at SYS-CON's @ThingsExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. delaPlex pioneered Software Development as a Service (SDaaS), which provides scalable resources to build, test, and deploy software. It's a fast and more reliable way to develop a new product or expand your in-house team.
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Five years ago development was seen as a dead-end career, now it's anything but – with an explosion in mobile and IoT initiatives increasing the demand for skilled engineers. But apart from having a ready supply of great coders, what constitutes true 'DevOps Royalty'? It'll be the ability to craft resilient architectures, supportability, security everywhere across the software lifecycle. In his keynote at @DevOpsSummit at 20th Cloud Expo, Jeffrey Scheaffer, GM and SVP, Continuous Delivery Busine...
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SYS-CON Events announced today that Progress, a global leader in application development, has been named "Bronze Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Enterprises today are rapidly adopting the cloud, while continuing to retain business-critical/sensitive data inside the firewall. This is creating two separate data silos – one inside the firewall and the other outside the firewall. Cloud ISVs ofte...
May. 26, 2017 01:45 AM EDT Reads: 3,202
DevOps at Cloud Expo – being held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real r...
May. 26, 2017 12:30 AM EDT Reads: 1,115
SYS-CON Events announced today that Systena America will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Systena Group has been in business for various software development and verification in Japan, US, ASEAN, and China by utilizing the knowledge we gained from all types of device development for various industries including smartphones (Android/iOS), wireless communication, security technology and IoT serv...
May. 26, 2017 12:30 AM EDT Reads: 889
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend @CloudExpo | @ThingsExpo, June 6-8, 2017, at the Javits Center in New York City, NY and October 31 - November 2, 2017, Santa Clara Convention Center, CA. Learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
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SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in compute, storage and networking technologies, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/...
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SYS-CON Events announced today that CollabNet, a global leader in enterprise software development, release automation and DevOps solutions, will be a Bronze Sponsor of SYS-CON's 20th International Cloud Expo®, taking place from June 6-8, 2017, at the Javits Center in New York City, NY. CollabNet offers a broad range of solutions with the mission of helping modern organizations deliver quality software at speed. The company's latest innovation, the DevOps Lifecycle Manager (DLM), supports Value S...
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SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers' changing business needs, enabling them to lower costs, improve performance and focus intern...
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A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
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The 21st International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Machine Learning and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding busin...
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Everywhere we turn in our industry we can find strong opinions about the direction, type and nature of cloud's impact on computing and business. Another word that is used in every context in our industry is "hybrid." In his session at 20th Cloud Expo, Alvaro Gonzalez, Director of Technical, Partner and Field Marketing at Peak 10, will use a combination of a few conceptual props and some research recently commissioned by Peak 10 to offer a real-world consideration of how the various categories of...
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In his opening keynote at 20th Cloud Expo, Michael Maximilien, Research Scientist, Architect, and Engineer at IBM, will motivate why realizing the full potential of the cloud and social data requires artificial intelligence. By mixing Cloud Foundry and the rich set of Watson services, IBM's Bluemix is the best cloud operating system for enterprises today, providing rapid development and deployment of applications that can take advantage of the rich catalog of Watson services to help drive insigh...
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SYS-CON Events announced today that SoftLayer, an IBM Company, has been named "Gold Sponsor" of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer's customers range from Web startups to global enterprises.
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Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deli...
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text: 2014 NFL Draft: 5 Day 2 Prospects the Seattle Seahawks Must Target By Jeremy Martin PREV NEXT 2014 NFL Draft: 5 Day 2 Prospects the Seattle Seahawks Must Target Getty Images The Seattle Seahawks proved they were the best team in the NFL last season. They are also the best team in the NFL when it comes to the NFL Draft. Seattle has hit on more draft picks than any other team in the last three seasons, and there is no reason to think that will change in 2014. Seattle's success is due to their ability to find talent on day two and three of the draft. Here are five players Seattle should target on day two this year. 5. Justin Ellis, DL Chuck Cook-USA TODAY Sports 5. Justin Ellis, DL Chuck Cook-USA TODAY Sports Seattle lost DT Red Bryant in free agency and could look for a replacement in the draft. Justin Ellis is a projected third rounder and could be a nice selection for the Seahawks. He had 48 tackles and 5.5 sacks in his senior season at Louisiana Tech. 4. Ego Ferguson, DL Getty Images 4. Ego Ferguson, DL Getty Images Another DT that will likely go in the third round is LSU defensive lineman Ego Ferguson. Ferguson had 58 tackles and one sack for the Tigers last season. 3. Jordan Matthews, WR Getty Images 3. Jordan Matthews, WR Getty Images Seattle also lost WR Golden Tate in free agency, and a possible replacement could be Vanderbilt WR Jordan Matthews. He is the cousin of legendary NFL WR Jerry Rice. In his last two seasons, Matthews recorded 201 receptions. 2. Will Sutton, DL Getty Images 2. Will Sutton, DL Getty Images Will Sutton is a defensive lineman out of Arizona State. Some believe he is a bit undersized, but some scouts compare him to Geno Atkins who has had three great seasons with the Bengals. 1. Donte Moncrief, WR Getty Images 1. Donte Moncrief, WR Getty Images One WR that might intrigue Seattle in the second round is Donte Moncrief of Mississippi. Moncrief ran great routes and had only one dropped pass last season. Teams in this article » Seattle Seahawks Share You May Also Like Related Stories Eddie Lacy, New Seattle Seahawks RB, Weighed 267 Pounds This Offseason Seattle Seahawks Find Themselves In Unfamiliar Position At Running Back Russell Wilson Goes To Twitter To Unveil New Nike Logo Ex-NBA Player Nate Robinson Gets Token Tryout With Seattle Seahawks Thomas Rawls Will Not End Up Being Seattle Seahawks' Top Running Back In 2016 Richard Sherman Says He Wouldn't Be Surprised If Marshawn Lynch Plays In 2016


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Perched on a cliff in beautiful La Jolla, this luxury resort offers stunning ocean views and is next to the internationally-renowned Torrey Pines golf course.
Experience authentic, turn-of-the-century charm and grace at The Lodge at Torrey Pines. In addition to its world-class golf facilities, this AAA Five-Diamond rated resort boasts a sumptuous spa retreat offering rejuvenating signature treatments based around coastal-botanical products.
The 170 spacious guest rooms range in size from 520 square feet to more than 1,500 square feet, with wonderful views of the golf course or The Lodge's central courtyard. Custom-designed furniture, fabrics and carpets give the rooms a feel of elegance and warmth, while high-tech details complete the luxury experience.
Other amenities include state of the art telecommunications, Bose wave stereo systems, complimentary high-speed internet access, 24-hour room service and more.
Experience high-end dining at The Lodge's top-rated A.R. Valentien restaurant, which offers elegant décor and superior cuisine in a magnificent setting. Enjoy casual and convenient dining at The Grill, or relax with a refreshing beverage at The Bar.
Accommodation details
11480 North Torrey Pines Road
San Diego
Check-in Details:
Normal Check-in: 16:00
Normal Check-out: 12:00
10.9 mi / 17.6 km from city centre
Room types and facilities
Total Number of Rooms - 170
Sleeps 4, Bed Type: King(s) or queen(s) Satellite television, Trouser/Pant press, Minibar, Refrigerator, Ceiling fan, Air conditioning, Separate Bath, Private bathroom, Separate Shower, Balcony/Lanai/Terrace, In Room Movies, Television
General facilities
- Health club
- Laundry/Valet service
- Business center
- Sauna
- Baby sitting
- Non-smoking rooms (generic)
- Spa
- Complimentary in-room coffee or tea
- Concierge desk
- Exercise gym
- On-Site parking
- Hair dryer
- Off-Site parking
- Internet services
- Tennis court
- Beauty shop/salon
- Ironing board
- Hairdresser/barber
- 5 Restaurant
- 1 Pool
- Aerobics instruction
- Whirlpool
- Jacuzzi
- Outdoor pool
- 2 Lounges/bars
- Golf
- Room service
- Game room
- Dry cleaning
- Shop
- Massage services
- Safe deposit box
- Driving range
- Elevators
- Steam bath