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While the Big Island doesn't traditionally pick up the same amount of tourist interest as some of Hawaii's other destinations, the state's namesake is still qualified – in our opinion – to call itself paradise.
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Welcoming guests with comfortable accommodations, dining venues and gracious service, Sheraton Princess Kaiulani offers Honeymoons, Destination Weddings, and Hotel accommodations beyond your dreams.
Radiating the graceful spirit of aloha, the Grand Hyatt Kauai Resort and Spa embodies the romance of Hawaii. Unfolding on 50 oceanfront acres, this resort shines with natural beauty and sensual ambiance. Enjoy a private dinner on the beach or indulge in a lavish couple's spa escape at Anara ...
Imagine an oceanfront ceremony as the Hawaiian sun sets into the glittering Pacific, an intimate reception in a turn-of-the-century ballroom... followed by a romantic honeymoon in a world of passion.
Waikiki is a thrillingly romantic destination unlike any other in Hawaii. Our dazzling location, professional planners, and ceremony location choices are sure to stir your passions.
White and gold beaches that go on for miles. Sunsets that last and last. With a setting this spectacular, romance comes with the territory.
From grand oceanfront ceremonies to elegant garden receptions, Sheraton Kauai offers assistance to help you plan an unforgettable wedding event of any size
Masterfully designed and richly furnished, this resort offers unique residences built alongside the fabled Ka'anapali Beach.
Say "The Royal Hawaiian" and the name evokes the world's greatest romantic wedding venue.
With the magical waters of Hanalei Bay in the background, the Westin Princeville Ocean Resort Villas provides the perfect setting for your special day.
Our specialists will customize and oversee each and every detail to your utmost satisfaction - Selecting a desirable indoor or outdoor setting in picturesque Maui.
Perched on 22 acres of dramatic lava cliffs at the ocean's edge is our contemporary, tropical retreat with Hawaiian-style hospitality. We invite you to our special setting on serene Keauhou Bay.
The incredible ocean and mountain views, delicious cuisine and Joe's friendly staff make this THE spot for Garden Isle weddings. We take care to ensure a memorable day for you, your family & friends.
Ultra-luxury property in Hawaii, located just steps away from Waikiki's famous white sand beaches & the new Waikiki Beach Walk offering vibrant entertainment, exclusive boutiques & world class dining.
Da Pink House provides a private, comfortable and tasteful setting where dreams come true. We welcome your family and friends for your big celebration.
St. Benedict's Church, with its unique art work, is listed in the Hawaii State Register of Historic places and the National Register of Historic Places.
Our beautiful 2,700 acre private property on the sunny North Shore of Oahu is the ultimate romantic Hawaiian location for your dream wedding!
A Sacred Union ~ Indoor or outdoor Ceremonies and Receptions with sweeping views of the Pacific Ocean and surrounding mountains. Hawaii Wedding Packages ~ Elegance with a touch of Green ~
Every member of our team would love the opportunity to be a part of your special day. Our Oceanfront lawn offers our brides unlimited possibilities when creating the Maui wedding of your dreams.
Recently opened, the new Ocean Crystal Chapel is the first free-standing resort chapel in Waikiki. You will be enchanted with the lush landscaping and surrounding cascading waterfalls.
Let our magnificent venues offer you and your guests stunning views, sounds of the surf, Hawaii's tropical breezes, and the world's most breathtaking sunsets.
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A romantic gazebo is positioned among the lush gardens with views that will make you feel like the world is at your feet. The silence, peace, and solitude make it an ideal place for exchanging vows.
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Celebrate your special day at this gorgeous oceanfront Kauai wedding destination, ideal for elaborate indoor receptions or intimate beach vows.
The site overlooks Onomea Bay, where the palm trees sway in the ocean breeze and the tropical scents tickle your nose.


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text: Home > Entertainment Art Acuña bags International Emmy nomination ABS-CBN News Posted at Oct 09 2012 12:33 PM | Updated as of Oct 10 2012 03:49 AM Share Save Facebook Twitter GPlus LinkedIn Art Acuña in a scene from "The Kitchen Musical" MANILA, Philippines -- Actor Arthur "Art" Acuña bagged a Best Actor nomination at the International Emmy Awards for his performance as Harry Shaw in the hit pan-Asian television series "The Kitchen Musical." Acuña is one of several FIlipino actors in the series, which also stars singers Christian Bautista and Karylle. "The Kitchen Musical" is also nominated for Best Drama. "Congratulations to the entire cast and all behind The Kitchen Musical ! Thanks for the good news Ana Karylle Padilla Tatlonghari," he said in his Facebook page. Acuña recently won Best Supporting Actor for the film "Posas" at this year's Cinemalaya Philippine Independent Film Festival. Last year, he also bagged the Best Supporting Actor trophy at the Urian Awards. The US-based actor has appeared in several Hollywood TV shows including "Law and Order," "Law and Order Criminal Intent," "One life To Live" and "As The World Turns." Currently, Acuña is also part of ABS-CBN's hit series "Princess and I" with Kathryn Bernardo. The International Emmys is scheduled on November 19 in New York. Share Save Facebook Share on Twitter GPlus LinkedIn Read More: the kitchen musical art acuna international emmys /entertainment/05/24/17/the-company-maglalabas-ng-bagong-album/entertainment/05/24/17/daniel-matsunaga-handang-maging-kaibigan-muli-si-erich/entertainment/05/24/17/why-jk-labajo-doesnt-mind-getting-hate-tweets/news/05/24/17/clear-and-present-danger-sa-metro-manila-wala-pa-ncrpo/video/news/05/24/17/law-expert-civil-rights-not-supplanted-by-martial-law


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Young offenders Cheshire
Halton, Warrington, Cheshire West and Chester Young Offenders Health Needs Assessment May 2015 - FINAL The Centre for Public Innovation is a Community Interest Company thatMore
Halton, Warrington, Cheshire West and Chester Young Offenders Health Needs Assessment May 2015 - FINAL The Centre for Public Innovation is a Community Interest Company thatMore
Visit the Joint Strategic Needs Assessment (JSNA) for data and intelligence www.cheshirewestandchester.gov.uk/JSNA 2015 mid year estimates of population Age Male Female Total KeyMore
There is limited data locally on inequalities that exist in terms of nutritional intake The majority of inequalities data for diet relates to fruit and vegetable consumptionMore
Drugs have a negative impact, from the crime impact on local neighbourhoods, the health impact on the individual, the social impact on families to the effect of internationalMore
This report provides a high-level overview of inequalities in Cheshire West and Chester Decile A method of splitting up a set of ranked data into 10 equally large subsectionsMore
Cheshire West and Chester's Black & Minority Ethnic Community Cheshire West and Chester Council Information has been gathered from a wide range of local, regional and national dataMore
has resulted in a large amount of data being recorded and photographs taken for over 100 This data has been summarised in the Character Area Assessments within this report and hasMore
Ellesmere Port Northwich and Winsford Chester Rural Communities 0 20 40 60 Source: Public Health Outcomes Framework data and ONS ADDE with 2011 MYE, Localities as atMore
in the number of TAF assessments completed. Data from TAFs opened in 2013/14 shows that a has been a challenge. Headline data shows this is progressing. • Receiving feedback fromMore
Cheshire West and Chester in February 2017 Unemployment estimates have gone down slightly There are issues with the Claimant Count data in that the coverage of the Universal CreditMore


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Heatstroke and sunstroke are similar. Sunstroke is a type of heatstroke. Heatstroke happens when the body's cooling system is overwhelmed. Sunstroke occurs when the body's cooling system fails.
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what is the differences between heatstroke and sunstroke?
Sunstroke is a form of heatstroke. Sunstroke is. "Heat stroke caused by exposure to the sun and characterized by a rise in temperature, convulsions, and coma. Also called insolation…more
What is the difference between the symptoms of heatstroke and sunstroke?
Symptoms of sunstroke or headstroke include elevated body temperature; hot, dry skin; hyperventilation; mental confusion, eventual unconsciousness….more
What are the symptoms of sunstroke or heatstroke?
It's hard to define sunstroke. For this discussion, let's think of it as we would heatstroke. Heatstroke happens when the body can no longer maintain a temperature of …more
What foods can you eat with sunstroke/heatstroke?
If you feel well enough to eat, I would recommend things that will replace the minerals and fluids that you may have sweated out. For example, a banana has lots of potassium so that…more


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Castelli Thermoflex Kneewarmer
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Do specifically the Northern Cardinal stay north for the winter?
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The northern cardinal eats a ... event or for the stresses of the coming winter. Typically, cardinals have two ... Northern cardinals are ...
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The northern cardinal ... Northern cardinals are numerous across the eastern United States from Maine to Texas ... Cardinals do not usually use their nests ...
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The Northern Cardinal is found in North ... to warn other male cardinals to stay away. The female cardinal will build the nest ... How do they communicate ...
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Northern Cardinal ... Unlike most northern songbirds, ... on the first sunny days of late winter, you may hear the cardinal's song.
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If you live in eastern North ... Northern cardinals do not migrate so they live in ... This version of How to Attract Cardinals was reviewed by ...
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Northern Cardinals eat mostly fruits and seeds throughout the year, but will ... Northern Cardinal Song: Sound: John R. Sauer: Northern ...
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Learn how to identify Northern Cardinal, ... Northern Cardinals eat mainly seeds and fruit, ... Pairs may stay together throughout winter, ...
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Kids' Inquiry of Diverse Species. ... Northern cardinals do not migrate so they live ... High altitude capture of a northern cardinal. North American Bird ...
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The Northern Cardinal! ... There were many cardinals at my feeder during the winter. This spring, ... Wild Birds Unlimited Home ...
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The northern cardinal ... they are particularly welcome in the winter when their brilliant plumage is a ... Northern cardinals will also appreciate a ...
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Read about Cardinalis cardinalis (northern cardinal) ... the winter home ranges of northern cardinals were ... of a northern cardinal. North ...
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Cardinal Bird Facts. ... Illinois, Indiana, Kentucky, North Carolina, ... Since cardinals do not stay in the same nest twice, ...
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Learn how to attract cardinals with these tips. Attracting northern cardinals is ... stormiest winter days. Because cardinals stay in the ...
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Northern Cardinal Habits. ... Every greeting card company in North America must use this ... Do Cardinals Go South In Winter? Northern Cardinals are ...
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Common Winter Birds of Central Minnesota. ... The Northern Cardinals ... Arrivals from further north during our winter are these birds.
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Northern cardinal Cardinalis ... Plant seeds and fruits comprise 90 percent of the cardinal's food in the fall and winter, ... Northern cardinals are now ...
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Why don't all birds fly south for the winter? And how do the ones that winter over in the frigid north survive? ... such as cardinals, ...
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Sarah 'Sally' McCoy[1]
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Video ClipsSee all »
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Thousands without power in N.J.00:39 — CBS News' Jeff Glor reports from New Jersey, where conditions are getting worse and thousands are already without power.
Pat Benatar and Neil Giraldo Celebrate Thanksgiving Day ParadeAhead of their performance of One December Night at the Macy s Thanksgiving Day Parade, the musicians chat with Al Roker about (more…)
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Doctors and other Health Care Professionals in Eglon WV
HealthCare4PPL is your most comprehensive directory of doctors and other health-care professionals in Eglon WV. HealthCare4PPL provides detailed information, including personal overview, history of education and training, specialities, practice locations, affiliated hospitals and more, of 1 Medicare-certified and other providers.
List of Doctors and other Health Care Professionals in Eglon WVThe list contains 1 physician
Andrew Miles Foy MD15+ years of experience
Credential: Doctor of Medicine (MD)
Primary Speciality: Family Practice
Newly Added Physicians
Andrew Miles Foy
2604 Grange Hall Road
Jennifer Gerlach
1600 Medical Center Dr Ste 3500
John H Stein
1005 White Willow Way
John Hagedorn
1 Stadium Drive 2nd Floor
Shena R Thomas
772 Deitz Rd
Nasser Moiduddin
1 Medical Center Dr
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In this full-featured trial you can: easily integrate your current systems (service desk, chat, monitoring etc.), communicate through any device, build on-call schedules and more. Start your 14-day free trial today!Sponsored Listing
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For 70 years, ACM has helped computing professionals like you to be their most creative, connect to peers, and see what's next, and inspired them to advance the profession and make a positive impact. It's why we show up every day. It's in our DNA. We believe in constantly redefining what computing can and should do. ACM offers the resources, access and tools to help you invent the future. Join ACM! Be creative. Stay connected. Keep inventing.Sponsored Listing
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JAllInOne is a suite of products First of all, it is an ERP/CRM SOA based application having a Swing UI. It manages item variants, warehouse, selling, POS, provisioning, order tracking, BOM, manufactures, accounting, callouts, agenda, documents and supports multiple languages/companies/currencies. JAllInOne Mobile is an Ajax based application, tuned for mobile devices to use for warehouse management (inward/outwards, inventory, etc) JAllInOne eCommerce is an Ajax based web application. It provides typical e-commerce features and is based on the same database and business logic of the other products.29 weekly downloads
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This year we get to enjoy two races on the first Tuesday in November. While the socialites strut their stuff at Flemington, political eyes will be on the US election.
This [series episode segment] has
Crikey correspondent Guy Rundle is in America on the campaign trail.
This week the Republican Party formally endorsed Mitt Romney as their presidential candidate at the 2012 Republican National Convention.
Sunday 7:00am
Presented by Tom Switzer
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Redrawing of boundaries has seen some marginal seats on an even-greater knife edge. Marginalia, examines these seats and look at what's at stake—who are the voters and how might they swing.
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Conceived and designed the experiments: CH WP TI NK MP CARDIoGRAM BT GP WK. Performed the experiments: CH WP TI DPVdK FLM UP NK MP CARDIoGRAM CM BT GP WK. Analyzed the data: CH WP JB MM MP CARDIoGRAM BT GP WK. Wrote the paper: CH. Edited and reviewed the manuscript: CH WP TI JB DPVdK FLM UP NK MM MR MP CARDIoGRAM MK CM BT GP WK.
The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events.
We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±4.8 years). Cox proportional hazard models adjusting for age, sex, body mass index, metabolic factors and lifestyle factors revealed no significant association between RANTES and incident coronary events (HR [95% CI] for increasing RANTES tertiles 1.0, 1.03 [0.75–1.42] and 1.11 [0.81–1.54]). None of six CCL5 single nucleotide polymorphisms and no common haplotype showed significant associations with coronary events. Also in the CARDIoGRAM study (>22,000 cases, >60,000 controls), none of these CCL5 SNPs was significantly associated with coronary artery disease. In the prospective Athero-Express biobank study, RANTES plaque levels were measured in 606 atherosclerotic lesions from patients who underwent carotid endarterectomy. RANTES content in atherosclerotic plaques was positively associated with macrophage infiltration and inversely associated with plaque calcification. However, there was no significant association between RANTES content in plaques and risk for coronary events (mean follow-up 2.8±0.8 years).
High RANTES plaque levels were associated with an unstable plaque phenotype. However, the absence of associations between (i) RANTES serum levels, (ii) CCL5 genotypes and (iii) RANTES content in carotid plaques and either coronary artery disease or incident coronary events in our cohorts suggests that RANTES may not be a novel coronary risk biomarker. However, the potential relevance of RANTES levels in platelet-poor plasma needs to be investigated in further studies.
Inflammation is one of the hallmarks of atherosclerosis [1]. Macrophage and lymphocyte recruitment and expression of proinflammatory immune mediators characterise the initial stages of atherogenesis, and inflammatory mechanisms also contribute to progression of atherosclerosis and to plaque disruption at later stages of the disease [2]. Although these immune-mediated mechanisms are only partially understood, an increasing number of studies indicates that chemokines are important mediators of cardiovascular risk [3]–[6].
Chemokines are proinflammatory cytokines that recruit leukocytes to sites of tissue damage or infection [7]. An interesting candidate in this context is RANTES (regulated on activation, normal T-cell expressed and secreted), also known as CCL5 (C-C ligand 5) [8]. RANTES predominantly mediates chemotaxis and activation of T cells, but also of monocytes, granulocytes, mast cells and dendritic cells [9]–[13]. RANTES is mainly expressed by T cells, but there are other important cellular sources such as platelets, adipocytes, monocytes/macrophages and fibroblasts [14], [15]. Increased expression in adipose tissue and increased serum concentrations of RANTES are associated with obesity, type 2 diabetes and other cardiovascular risk factors [16]–[20].
Several lines of evidence indicate that RANTES plays a role in the pathogenesis of cardiovascular diseases. In mice, RANTES is expressed in atherosclerotic lesions and both RANTES antagonists and deletion of the gene encoding the RANTES receptor CCR5 can reduce the progression of atherosclerosis or early myocardial reperfusion [21]–[24]. In humans, the situation is less clear. Although RANTES expression has been shown convincingly for the various cell types in atherosclerotic plaques [reviewed in ref. 6], studies on the relevance of circulating RANTES concentrations as biomarker for cardiovascular risk are scarce. Moreover, population-based data on the ability of RANTES levels to predict coronary events are currently not available. Some reports on associations of polymorphisms in the genes encoding RANTES and CCR5 with coronary artery disease (CAD) also support the notion that RANTES plays a role in the development of cardiovascular disease [25].
We hypothesised that the relevance of RANTES in the development of atherosclerosis should be reflected by associations between CCL5 genotypes, systemic RANTES levels as well as RANTES levels in atherosclerotic plaques and risk for coronary events. We tested the first two parts of this hypothesis by assessing the relationship between CCL5 gene (encoding RANTES protein) variants and RANTES serum levels with cardiovascular risk in the German MONICA/KORA Augsburg case-cohort study. In addition, the association between CCL5 genotypes and CAD was analysed in the large CARDIoGRAM study [26], [27]. For the third part of the hypothesis, we used carotid atherosclerotic plaques from the Dutch Athero-Express biobank study. Recently, we provided evidence that composition and biomarkers from carotid plaques predict cardiovascular outcomes [28]–[31]. Therefore, we investigated the associations between RANTES protein levels in plaques with histological plaque phenotypes and conducted a second prospective study to test whether local carotid RANTES plaque levels were associated with future coronary events.
This study is a prospective case-cohort study [32] within the population-based MONICA/KORA Augsburg studies [33]–[35]. Data were derived from three independent cross-sectional, population-based surveys within the MONICA project in 1984/1985 (S1), 1989/1990 (S2) and 1994/1995 (S3) in Augsburg (Germany) and two adjacent counties. The studies were approved by the local authorities and performed according to the Declaration of Helsinki. The case-cohort study was approved by the Bayerische Landesärztekammer (Bavarian Medical Association). All participants provided written informed consent.
Response rates for the different surveys were 75.7% (S1), 74.4% (S2) and 73.1% (S3). The total number of study participants was 13,427 (6725 men, 6702 women) aged 25–64 (S1) or 25–74 years (S2, S3). All subjects were prospectively followed within the KORA framework until 2002.
The outcome variable "coronary events" was defined as combined endpoint that consisted of incident non-fatal myocardial infarction (MI) and fatal coronary death or sudden cardiac death before the age of 75 years. Cases were identified through the MONICA/KORA Augsburg coronary event registry. In addition, follow-up questionnaires were sent to persons who had moved out of the study area. Until December 2000, a major non-fatal MI was diagnosed based on the MONICA algorithm (symptoms, cardiac enzymes, ECG changes). Since January 2001 myocardial infarction was diagnosed according to criteria defined by the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) [36], [37]. Coronary deaths were validated by autopsy reports, death certificates, chart review and information from the last treating physician.
Due to the low incidence of coronary events in individuals below 35 years of age, we limited the present study to persons aged 35–74 years at baseline (5382 men, 5336 women). Due to missing blood samples, 1187 subjects had to be excluded which led to a total source population of 9531 subjects (4696 men, 4835 women). Participants with self-reported prevalent coronary heart disease were also excluded, leading to a final source population of 9300 subjects (4507 men, 4793 women). For the case-cohort study, we selected a random sample of the source population (called subcohort) stratifying by sex and survey. The final stratum-specific sample sizes of this subcohort were used together with the stratum-specific sizes of the source population to compute sampling fractions, and the inverse of the sampling fractions yielded the survey and sex-specific sampling weights. All cross-sectional analyses were performed in the subcohort which included 2077 subjects (1112 men, 965 women) after exclusion of subjects with missing values for classical cardiovascular risk factors and essential inflammatory markers. Until December 31, 2002, 397 study participants had a coronary event according to our endpoint definition (307 men, 90 women). After further exclusion of subjects with incomplete information on relevant variables, the present study was based on 2271 participants (280 men, 83 women with incident coronary events; 976 men, 932 women who remained event-free). The majority of cases (n=318, 87.6%) occurred before the end of 2000 when the diagnosis criteria were changed from the MONICA algorithm to the ESC/ACC criteria. Cases with incident coronary events included 175 participants with non-fatal MI and 188 cases with fatal coronary death or sudden cardiac death. The mean follow-up time (± standard deviation) was 10.2±4.8 years.
Sociodemographic and lifestyle variables as well as data on parental history of myocardial infarction were collected through standardised interviews. Standardised medical examinations including collection of a non-fasting venous blood sample for the determination of biomarkers were performed. All procedures and routine laboratory methods have been described in detail elsewhere [33]–[35].
Serum levels of RANTES were determined using the Human CCL5/RANTES Quantikine ELISA kit from R&D Systems (Wiesbaden, Germany) as described [38]. Mean intra-/inter-assay coefficients of variation were 4.2% and 5.1%, respectively, for recombinant controls, and 4.1% and 6.4%, respectively, for test sera.
Six single nucleotide polymorphisms (SNPs) were selected on the basis of data from the International HapMap project (http://www.hapmap.org) to obtain complete coverage of the CCL5 gene for a 9.2-kb locus of the CCL5 gene (promoter: rs2107538 [−403G>A], rs2280788 [−28C>G]; intronic: rs2280789, rs4796120, rs3817655; 3′-flanking region: rs1065341). All SNPs were in Hardy-Weinberg equilibrium (p>0.2). Genotyping was carried out with matrix-assisted laser desorption ionisation-time of flight analysis of allele-dependent primer extension products as reported [39]. A subset of samples (13.3%) was genotyped in duplicate to assess genotyping quality. The mean discordance rate for the six SNPs was 0.44%.
Baseline continuous characteristics of the study participants were described using the SAS procedure SURVEYMEANS which estimated standard errors appropriate to the sampling scheme. Categorical variables and continuous variables were compared between cases and non-cases by Wald chi-square test (SURVEYFREQ) and t tests on regression coefficients (SURVEYREG), respectively. In case of non-normality, t tests were carried out for log-transformed variables, and results were given as geometric means with antilogs of standard errors of the adjusted log-means.
The associations of CCL5 genotypes and RANTES serum levels with incident coronary events were assessed by Cox proportional hazard models. The proportional hazards assumptions for the Cox models were tested for all models graphically before the analyses and demonstrated that proportional hazards can be assumed. The case-cohort design required correction of the variance estimation based on the sampling weights to give standard error estimates for the parameter estimates. Correction for standard errors was made using the method by Barlow [32]. The inverse of the sample sizes for the subcohort by the cohort of interest yielded survey and sex-specific sampling weights. If required we additionally differentiated between cases and non-cases. Sex-specific tertiles of the weighted distributions of RANTES serum levels in the subcohort were used. Tests for trend were conducted assigning the median value within each tertile to the corresponding tertile and including this variable in the Cox regression model. A p value of <0.05 was considered to be statistically significant for the analysis of RANTES serum levels. For analyses regarding the 6 CCL5 genotypes, the significance level was adjusted for multiple testing according to Bonferroni to 0.05/6=0.0083 for each SNP. All calculations were performed with SAS (Version 9.1, SAS Institute Inc., Cary, NC, USA).
The transatlantic CARDIoGRAM (Coronary ARtery DIsease Genome-wide Replication And Meta-analysis) Consortium combines data from 14 genome-wide association studies (GWAS) comprising >22,000 cases with CAD and >60,000 controls, all of European ancestry [26], [27]. Cases and controls participated in case-control or prospective cohort studies, and the case definition in the participating studies comprised CAD, MI or both (see ref. 26 for a detailed list of studies and case/control definitions). Genotype data were available from measurements on Affymetrix and Illumina platforms with subsequent imputation of genotypes in most studies [26]. The associations of CCL5 alleles with CAD were assessed by calculating unadjusted odds ratios (OR) with corresponding 95% CI and p values per specified allele. The nominal significance level was adjusted for multiple testing according to Bonferroni to 0.05/6=0.0083 for each SNP in this study. The level of genome-wide significance that corrected for all tests performed in the GWAS was set at 5×10−8.
The Athero-Express study is an ongoing biobank study with a longitudinal study design, comprising atherosclerotic plaques obtained from patients who underwent carotid endarterectomy (CEA) as described [40]. A multidisciplinary vascular team reviewed all indications for surgery. For the present study we included 606 atherosclerotic plaques from patients operated between 24 March 2002 and 15 December 2006. The study design has been reported previously [41]. All patients completed questionnaires including medical history and medication use prior to the operation. Patients who suffered from stroke, transient ischemic attack (TIA) or amaurosis fugax (AFX) were considered as symptomatic. Patients operated due to a significant stenosis of more than 70% and without neurological manifestations were considered as being asymptomatic. Hypertension and hypercholesterolaemia were defined as use of anti-hypertensive drugs (diuretics, beta blockers, calcium antagonists, ACE inhibitors, angiotensin II antagonists) or cholesterol-lowering drugs (statins, fibrates, acipimox, ezetimibe, colestyramine), respectively. After surgery, patients were clinically followed for up to 3 years. The composite endpoint was defined as fatal MI, sudden death, non-fatal MI and coronary intervention (including coronary bypass and coronary angioplasty). The medical ethics committees of the participating hospitals (University Medical Center Utrecht, Utrecht, and St Antonius Hospital Nieuwegein, The Netherlands) approved the study, and all participants provided written informed consent.
The collected atherosclerotic plaques were processed according to a standardised protocol [41]. Briefly, plaques were cut into small segments of 5 millimeters along the longitudinal axis. The segment with the greatest burden was considered the culprit lesion, which was subjected to histological assessment. Macrophage infiltration (CD68) and smooth muscle cell infiltration (α-actin) were quantified and expressed as percentage staining of the plaque area using computerised analyses. In addition, calcification (haematoxylin and eosin (H&E)), collagen content (Sirius Red) as well as the macrophage and smooth muscle cell stainings were scored semiquantitatively as "no", "minor", "moderate" or "heavy" staining [41]. The size of the lipid core (H&E and Sirius Red) was visually estimated as the percentage of the total plaque area, and plaque haemorrhage (fibrin) was scored as being present or absent. Two independent observers performed the histological examinations. The histological assessments showed good interobserver reproducibility and the semi-quantitative examinations correlated excellently with the computer-based assessments [42].
The segments adjacent to the culprit plaque lesions were used for protein isolation. Segments were dissolved in Tris buffer according to a standardised protocol and quantified for the total amount of protein [41]. RANTES levels were quantified by a multiplex assay from Bender MedSystems (Vienna, Austria) according to the manufacturer's protocol. RANTES levels were corrected for total amount of protein within the segment.
Baseline RANTES levels in plaques were statistically analysed by the non-parametric Mann Whitney-U test. The association of RANTES expression with categorised histological plaque characteristics was assessed using Spearman's correlation test. The association between plaque haemorrhage and RANTES expression was determined by the Mann Whitney U test.
We used unadjusted Cox regression analyses to determine the association of RANTES plaque levels at baseline with cardiac outcome during the follow-up. In order to exclude potential confounding with respect to the association of RANTES plaque levels and cardiac endpoint, we performed multivariate analyses including all determinants that were significantly associated with RANTES expression levels at baseline. The statistical analyses were performed using SPSS 15.0 (SPSS Inc, Chicago, IL, USA).
Individuals who experienced a coronary event during the follow-up (cases) differed in most baseline characteristics from individuals without incident coronary events (non-cases). Cases were older, had a higher BMI, higher waist-to-hip ratio, higher blood pressure, more frequently a history of hypertension or diabetes, higher total and LDL cholesterol levels, lower HDL cholesterol levels, higher ratio of total to HDL cholesterol, higher systemic concentrations of CRP and IL-6, and were less frequently physically active. These data have been reported before [43] and are given in the supporting information (Table S1).
RANTES serum levels did not differ significantly between cases and non-cases (mean 29.6 vs 28.0 ng/ml, p=0.085). Cox proportional hazard models showed that increasing tertiles of RANTES serum concentrations were neither associated with increased risk of coronary events after adjustment for age, sex and survey (Table 1, model 1) nor after additional adjustment for anthropometric, metabolic, immunological and lifestyle factors (Table 1, models 2 and 3).
In order to assess whether RANTES serum levels may be more informative for a shorter follow-up period, we repeated the analysis for coronary events occurring in the first three years (84 cases, 2187 non-cases) or in the first five years (156 cases, 2115 non-cases). HRs (95% CIs) for increasing tertiles were 1.0, 1.10 (0.62–1.98) and 1.03 (0.57–1.86) for a follow-up time of three years (ptrend=0.90) and 1.0, 1.04 (0.67–1.61) and 1.06 (0.68–1.66) for a follow-up time of five years (ptrend=0.88) and thus very similar to results obtained from the complete follow-up period.
Since we used non-fasting samples, we investigated the potential impact of the duration of fasting on RANTES levels. Mean duration of fasting did not differ between cases and non-cases, RANTES levels did not correlate significantly with duration of fasting in the subcohort (analysis adjusted for age, sex and survey), and additional adjustment for this variable in model 3 had no impact on HRs (data not shown).
Carriers of the minor alleles of the CCL5 SNPs rs2107538, rs2280789, rs47966120 and rs3817655 had significantly lower RANTES serum levels (padditive≤3.1×10−8) than carriers of the major alleles in the MONICA/KORA subcohort, whereas no differences were found for rs2280788 and rs1065341 as reported previously [38]. In line with the data for serum levels, individuals who were heterozygous or homozygous for the minor alleles of the six SNPs investigated here had no decreased risk for coronary events compared to study participants who were homozygous for the respective major alleles (Table 2).
Based on the six aforementioned CCL5 SNPs, haplotypes were constructed. None of the common haplotypes with frequencies of ≥1% in the subcohort had a statistically significant impact on the risk of coronary events compared to the most frequent haplotype CCTATA (Table 3). However, individuals who carried any of the rare haplotypes (frequencies <1% in the subcohort) had a fourfold increased risk of coronary events when these haplotypes were analysed together compared to the carriers of haplotype CCTATA (Table 3).
Associations between the CCL5 SNPs rs2107538, rs2280788, rs2280789, rs4796120, 3817655 and rs1065341 and CAD were assessed in up to 82,387 individuals (>22,000 cases and >60,000 controls) in the CARDIoGRAM study (Table 4), but none of the associations reached statistical significance.
Baseline characteristics of the Athero-Express biobank study participants and RANTES protein levels in carotid plaques stratified by clinical variables are shown in Tables 5 and and6.6. In an unadjusted analysis, RANTES plaque levels were lower in women compared to men and in patients with diabetes compared to non-diabetic individuals, whereas no differences were seen for other anthropometric or metabolic parameters such as BMI, hypertension or hypercholesterolaemia. Among the cardiovascular parameters, the presence of bilateral stenosis was associated with higher RANTES levels, whereas no differences could be detected for histories of vascular intervention or myocardial infarction. Increased RANTES plaque levels were also associated with increased systemic CRP levels.
At the histological level, RANTES plaque levels were higher in plaques with less pronounced calcification (p=0.009) and there was a trend toward higher RANTES levels in plaques with increased macrophage infiltration (p=0.054), suggesting an association between high RANTES levels and an unstable plaque phenotype. We also found a trend for an association between RANTES levels and lipid content, but not with smooth muscle cell infiltration, collagen content, or presence of plaque haemorrhage (Table 7).
During a mean follow-up of 2.8 years (SD 0.8 years, maximum 3 years), 51 study participants (8.5%) reached a cardiac endpoint (cases). These included 31 individuals who died and 20 individuals who underwent a cardiac intervention due to coronary artery disease. RANTES plaque levels did not differ between individuals without and with events (median [25th percentile, 75th percentile] 44.86 [29.04–74.96] vs 57.77 [34.52–79.90] ng/µg; respectively; p=0.12). When the event rates of individuals with high (above the median of 45.52 ng/µg) and low (<45.52 ng/µg) RANTES levels in plaques were compared, unadjusted Cox regression analysis revealed no association with higher event risk for higher RANTES levels (HR [95% CI] 1.51 [0.86–2.64], p=0.16) (Fig. 1, Table 8). Adjustment for baseline determinants of RANTES levels (i.e., sex, diabetes status, presence of bilateral stenosis, CRP) attenuated the association even further (HR [95% CI] 1.01 [0.99–1.01]; p=0.87).
Our study has three main findings: (i) RANTES serum levels were not associated with incident coronary events in the MONICA/KORA Augsburg case-cohort study, (ii) functional RANTES/CCL5 SNPs were not associated with CAD in the large CARDIoGRAM study, and (iii) RANTES levels were associated with an unstable phenotype of carotid plaques, but no independent predictor of future coronary events in the Athero-Express study.
Prospective studies on systemic RANTES levels and cardiovascular outcomes are very scarce and controversial. Whereas higher 2-year cardiac mortality in male patients undergoing coronary angiography has been found associated with reduced levels of RANTES plasma levels [44], elevated RANTES levels predicted future cardiovascular events in a small sample of patients with unstable angina pectoris [45]. In patients with acute coronary syndromes RANTES plasma levels were – in contrast to concentrations of most other biomarkers measured - not predictive of future cardiovascular events [46]. In all three studies, the number of incident cases was substantially lower than in the MONICA/KORA Augsburg case-cohort study, and follow-up periods were shorter. Furthermore, these aforementioned studies were performed in subjects with suspected and/or preexisting cardiovascular disease, which limits the conclusions that can be drawn regarding cardiovascular risk in the general population. Therefore, our prospective MONICA/KORA Augsburg case-cohort study extends the current literature as it represents the first large, population-based study to characterise the relationship between systemic RANTES concentrations and cardiovascular outcomes.
In recent years, several candidate studies analysed whether CCL5 SNPs could serve as biomarkers for cardiovascular risk. Most data are available for the CCL5 SNP rs2107538 which is also known as −403GA. This SNP is likely to be functional as we showed in the MONICA/KORA cohort before that carriers of the minor allele had significantly lower RANTES serum levels [38]. Alleles or genotypes of rs2107538 were associated with CAD in patients who underwent coronary angiography [47], with all-cause mortality (mainly attributable to cardiac events) in patients with type 2 diabetes and end-stage renal disease [48] and with presence and severity of CAD in patients subjected to percutaneous coronary intervention [49]. In contrast, rs2107538 variants showed no associations with CAD in a case-control study [50] or with presence of significant (>50%) stenosis in patients who underwent elective coronary angiography [51]. Overall, these data were inconclusive with regard to associations between rs2107538 and cardiovascular disease, were confined to patient groups and therefore cannot be extrapolated to the general population.
Given the low statistical power of the aforementioned single studies it is of interest that associations with genome-wide significance have not been reported for SNPs in or near the CCL5 locus in recent GWAS that covered this genomic region [27], [52], [53], [54]. However, from these reports it was not clear whether this lack of evidence was most likely due to an absence of any association or whether results for SNPs in/near this locus suggested that genome-wide significance could be reached by a reasonable increase in sample size.
The data from the MONICA/KORA study represent the first report on associations between CCL5 genotypes and incident coronary events from a population-based study. Due to limited statistical power we sought to substantiate our findings in the CARDIoGRAM consortium, currently the largest database on gene variants and CAD worldwide. As recently published, the CARDIoGRAM study is adequately powered to reveal associations at genome-wide significance level (p<5×10−8) between common SNPs and CAD even for allelic OR of <1.10 [27], but associations between CCL5 genotypes and CAD were not nominally significant and far from genome-wide significance. It should be noted that in contrast to the prospective MONICA/KORA Augsburg case-cohort that evaluated risk factors for incident coronary events the CARDIoGRAM study investigated gene variants that are associated with prevalent CAD and thus does not represent a perfect replication sample. However, we believe that any major impact of RANTES genotypes on coronary risk should also have been reflected by an association with prevalent disease so that the CARDIoGRAM data add relevant information to the initial findings from the MONICA/KORA Augsburg case-cohort study.
The MONICA/KORA Augsburg study also allowed for the evaluation of haplotypes as risk factors of coronary events. Our data indicate that rare haplotypes may indeed comprise variants that are associated with increased coronary risk. However, this study does not have the statistical power to analyse this aspect in more detail, and data on DNA sequences would be needed to identify defined haplotypes with potential relevance for pathogenesis and prediction. Therefore, this finding is hypothesis-generating at best and needs corroboration in further studies.
Taken together, our data strongly suggest that the six CCL5 SNPs that we included in our study and the major haplotypes based on them may not be relevant biomarkers for the prediction of cardiovascular events.
Data from mouse models demonstrate that RANTES and its receptor CCR5 are expressed in atheromas, that they play a causal role in atherogenesis in these models and that interference with leukocyte migration at this level may represent a promising therapeutic approach to prevent or delay atherosclerotic processes [5]. Hence, it can be hypothesised that higher RANTES levels may be indicative of elevated cardiovascular risk.
Higher CCL5 gene expression has indeed been reported in atherosclerotic tissue from individuals with symptomatic carotid plaques (i.e., symptoms within the past 6 months) compared to CCL5 gene expression in iliac arteries from organ donors [55]. In contrast, several chemokines were upregulated in downstream compared to upstream portions of carotid plaques in patients undergoing carotid endarterectomy for extracranial high-grade internal carotid stenosis, but no differences in gene expression could be seen for CCL5 [56]. In the Atherosclerosis Risk in Communities (ARIC) Carotid MRI study, RANTES plasma levels were associated with the extent of atherosclerosis and high-risk plaques, but RANTES levels in plaques were not measured in this study [57].
Our findings from the Athero-Express study extend current knowledge on RANTES plaque levels as potential biomarker because it relates RANTES plaque levels and risk for coronary events in a prospective design. Although we observed a trend toward higher risk for higher RANTES plaque levels, this association was completely abolished when we accounted for several established cardiovascular risk factors in a multivariate analysis. However, it should be noted that we found an association between RANTES and an unstable plaque phenotype which is in line with previous studies investigating the potential role of RANTES in the development of cardiovascular disease. It is noteworthy that some of the classical cardiovascular risk factors such as male sex, diabetes or systemic CRP were not significantly associated with the risk for coronary events in the multivariate model. We hypothesise that both the low number of events (compared to studies like the MONICA/KORA Augsburg case-cohort study) and the fact that the study sample represents a high-risk group that differs from the general population may have contributed to this finding.
The combination of three independent studies to investigate different biological levels (gene variants, local and systemic protein concentrations) of RANTES in order to assess their use as potential biomarkers for the risk of coronary events represents the main strength of our study. Our findings are based on study cohorts that have been used before to identify novel associations between inflammation-related proteins (MONICA/KORA, Athero-Express), gene variants (CARDIoGRAM) and cardiovascular risk. The MONICA/KORA study is the first population-based study to examine the relationship between CCL5 SNPs, RANTES serum levels and risk for coronary events. Its strengths include the population-based design, a long follow-up and a large number of cases. The Athero-Express study also represents the first study to test whether RANTES plaque levels predict cardiovascular outcome. The fact that the same cohort and the same methods allowed us to identify other prognostic proteins in carotid plaques such as fatty-acid binding protein, matrix metalloproteinase-8 and osteopontin as predictors of cardiovascular events underlines that the study design is indeed suitable to address our study question [29]–[31]. The CARDIoGRAM database is currently the largest database worldwide on common SNPs and CAD and thus the best available data source for our study aim.
In the MONICA/KORA Augsburg case-cohort study we measured RANTES in serum samples which is important to note because RANTES is released by platelets during the clotting process. Therefore, we cannot exclude that the analysis of platelet-poor or platelet-free plasma would have led to different results. Platelet count is only available in MONICA/KORA survey 3, so that we could not adjust for this potentially relevant confounder in our analysis. A general limitation of current studies on RANTES and disease outcomes, including our own (MONICA/KORA and Athero-Express), is the fact that commercially available assays measure total RANTES protein, although variant forms including truncated proteins and proteins with different oxidation, glycation and glycosylation patterns exist. More research is needed to reveal whether these variants may be more informative in prospective studies than total RANTES levels [58]. Finally, the CARDIoGRAM consortium combined studies with different designs and outcome definitions which can be expected to attenuate associations between genetic variation and risk for coronary events.
We found an association between high RANTES plaque levels and an unstable plaque phenotype, but no associations of (i) RANTES serum levels, (ii) CCL5 genotypes and (iii) RANTES content in carotid plaques with coronary artery disease or incident coronary events in our cohorts. These data indicate that RANTES/CCL5 gene variants and protein levels may not be novel biomarkers for the risk of coronary events in humans. However, our study could not address the questions whether measurement of RANTES in platelet-poor plasma or measurement of variant forms of RANTES proteins (locally or systemically) may be more informative for cardiovascular risk prediction than the approaches we pursued. Moreover, we cannot exclude that the measurement of RANTES may be of prognostic benefit in specific patient groups.
Members and affiliations of the CARDIoGRAM Consortium are listed in the Supplementary Information.
Funding information and competing interests of the CARDIoGRAM Consortium.
Baseline demographic, lifestyle and clinical characteristics of the study participants without and with incident coronary event during follow-up (MONICA/KORA Augsburg case-cohort study).
We thank all members of the Institutes of Epidemiology I and II and the Research Unit of Molecular Epidemiology at Helmholtz Zentrum München and the field staff in Augsburg who were involved in the planning and conduct of the MONICA/KORA Augsburg studies. Furthermore, we thank Ulrike Poschen (German Diabetes Center, Düsseldorf) for excellent technical assistance with RANTES measurements in serum and Lloyd Chambless (School of Public Health, University of North Carolina at Chapel Hill, NC, USA) for statistical assistance with the analysis of the case-cohort dataset. We thank Evelyn Velema and Kristy Vons for their contributions in the histological assessments. Finally, we express our appreciation to all study participants. CARDIoGRAM thanks the participants and staff in each of the studies who contributed to the present article.
Competing Interests: The authors have declared that no competing interests exist. Potential competing interests related to the funding of the CARDIoGRAM Consortium are listed in our supplementary file entitled "Text S2. Funding information and competing interests of the CARDIoGRAM Consortium".
Funding: The MONICA/KORA Augsburg case-cohort study was supported by research grants from the German Research Foundation (TH-784/2-1, TH-784/2-2) and by additional funds provided by the German Diabetes Center (Düsseldorf, Germany); the Federal Ministry of Health (Berlin, Germany); the Federal Ministry of Education, Science, Research and Technology (National Genome Research Net-2, cardiovascular, 01GS0423; Berlin, Germany); the Ministry of Innovation, Science, Research and Technology of the state North Rhine-Westphalia (Düsseldorf, Germany); Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (formerly GSF National Research Center for Environment and Health; funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria); and the University of Ulm. The MONICA/KORA Augsburg cohort study was financed by the Helmholtz Zentrum München and supported by grants from the Federal Ministry of Education and Research, Berlin, Germany. The Athero-Express study was partially funded by the University Medical Center Utrecht. For the complete list of funders of the CARDIoGRAM Consortium and their support information, please refer to our supplementary file entitled "Text S2. Funding information and competing interests of the CARDIoGRAM Consortium". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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AIWA SXNS552 U/LH Service Manual
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WB polls: CPM's youngest candidate has no asset
The youngest candidate in WB polls, Shatarup Ghosh of CPM has no immovable or movable asset.
Kolkata: The youngest candidate in West Bengal Assembly election, Shatarup Ghosh of CPM contesting from Kasba constituency, has no immovable or movable asset.
In his affidavit filed during submission of the nomination, Ghosh said he possessed only Rs 308.90 -- Rs 250 in hand and Rs 58.90 in the bank. He has no property purchased or inherited.
Asked whether he was the poorest candidate, an Election Commission official said, "It is very hard to say specifically. But as far as I know there is no one till now who has less assets than him."
The Left Front has fielded the 25-year-old student against seasoned Trinamool Congress candidate and sitting MLA Javed Khan. Asked about his prospects in the election, Ghosh told PTI, "I will win. I am well received by the people of the locality."
On being asked about his rival, who is a seasoned politician, Ghosh said, "That matters little when it comes to voting. I have full confidence on the people."
Ghosh, who is currently doing his post graduation, had led SFI supporters to TMC supremo Mamata Banerjee's house after a clash broke out between SFI and TMC Chatra Parishad at Asutosh College where nine students were injured in December last year. A student of South Point High School, Ghosh became a party full timer after admission in Asutosh College to quickly rise as a student leader.
With a bulk of the electorate comprising youth, the young brigade of the Left Front is strongly campaigning for Shatarup. Those campaigning for him were Housing Minister Goutam Deb's son Saptarshi, Health Minister Surya Kanta Mishra's daughter Roushnara, CPM MP and CITU State President Shyamal Chakraborty's daughter Ushasi and former CPM state secretary Anil Biswas' daughter Ajanta Dey.
"This is a red fort and I want to win from this prestigious constituency," Ghosh said.
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These guys are great! Cleanest gas station I have ever seen. Polite and friendly staff. Even have some tasty BBQ!!!
Vero Beach, FL Siffords Exxon Service Center
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1550 Us Highway 1Vero Beach, FL 32960
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Blaque Member Natina Reed Killed in Hit-and-Run Accident
Natina Reed, most famous for being one part of female group Blaque, was killed in a hit-and-run accident, just several days before her 33rd birthday. The singer, who also starred in 2000 flick "Bring It On", was struck by a car in metro Atlanta on late Friday, October 26.
Police said Reed was hit in the roadway at an intersection on U.S. 29 near Lilburn at about 10:30 P.M. "The driver of the vehicle contacted 911 to request assistance," the press release from Gwinnett (Ga.) Police Department stated. "Natina Reed was pronounced dead at Gwinnett Medical Center at 10:59 P.M. E.S.T."
The release continued, "Preliminary information indicates that Reed was in the roadway on Lawrenceville Highway near Hamilton Road when struck." Police said that the driver "was determined to be not at fault and there are no charges pending."
Reed is survived by 10-year-old son, Tren Brown, whose father is rapper Kurupt. She would have turned 33 on Sunday.
Condolences have been pouring in from every corner. "We are devastated by the loss of our group member, sister and friend Natina Reed," Blaque members Brandi Williams and Shamari Fears-DeVoe said in a statement. "Because of the enormous support of Blaque fans and our love for each another, Blaque officially reunited this fall and we were in the process of working on a new album and a reality show."
"Natina continuously embodied the pioneering spirit of Blaque and her undeniable creativity touched the hearts of fans everywhere. Natina was a mother, sister, accomplished songwriter, artist and friend. We ask for your prayers at this time for Natina's family. She will forever be missed and her global influence eternally felt. We thank God for the experiences we shared."
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Chris Taylor's Side Project
They should just let Chris Taylor write all of their songs. Thats what Veckatimest should have sounded like.
Veckatimest is awesome anyway, but this stuff sounds good.
Song rules.
• R.I.P. David Bowie• The Story So Far's vocalist dropk..• R.I.P. Lemmy• Brand new Brand New Single• Scott Weiland dead at 48 • Killswitch Engage debut new single• Deftones stream new single• The Fall of Troy bassist melts do..• Rush drummer retires• Riverside guitarist dies
• New Ice Nine Kills song• Divinity release an LP• R.I.P. Gregg Allman• New Goldfinger video and album• Another New CHON Video• New Band-Maid single• Martin Garrix/Troye Sivan song• Ufomammut debut new single• New Count to Altek album out• Edguy new song and album• Young Lions Detail New Album• Third Eighteen Visions track• Neun Welten Dive In• Below the Sun air new LP• Wode stream new album » see all news
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2 Nanny Jobs Found
Summer Sitter
Posted by Melissa T. on 5/21/2017
- 23 miles away (Bloomington, IL)
- $10–12/hr
- 2 children
Bloomington family needs a babysitter who can fill the kids' days with a variety of fun outings and amusement. Must love kids, cats and dogs! Duties will include some light tidying up, pickups / drop-offs, and preparing meals. We'd like someone who has experience with children with special needs or... More
Summer Sitter
Posted by Katie M. on 5/15/2017
- 23 miles away (BLM, IL)
- $10/hr
- 2 children
Looking for a summer nanny for my twin boys. Both have autism so must have the heart to work with special kids. Also may turn into before and afterschool care come fall.


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Rubbermaid Trash Can Lid, 32-Gallon
by RUBBERMAID INC
Price: $9.64
- Durable and strong
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Product description
This durable lid is an extra lid for the 32 gallon roughneck trash can No.824-466. Fits securely and tightly onto trash can safely so you do not have to worry about it coming loose or blowing away in the wind.
Stainless Fortify Replacement Lid for 80 Liter Hands-Free Trash Can
by Nine Stars
Price: $41.49
- Measurement: H: 19 x W: 7 x D: 5
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Product description
Model: TRASH-LID-4Replacement Lid for DZT-80-4 Dimensions: H: 19 x W: 7 x D: 5Advance state of the art proximity infrared sensorQuiet swing opening mechanismLow battery indicator lightLow energy consumptionRequires four (4) D batteries (not included)Will open and close nearly 10,000 times before requiring battery replacement


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