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Scribe is a CMS for the Liferay Portal framework. It includes Web Content Management as well as Learning Management System features.
A port of the venerable Java SiteMesh web-page layout and decoration framework to PHP5.
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Sitemap Generator is a development tool to generate a google compatible sitemap.xml, an html style sitemap page and a diagram of sitemap of a website.
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This project is designed to help assist the online Role Playing Community in the management of their data and websites by providing an easy to use PHP and MySQL based administration site for Play by Email, Play by Forum and Play by IRC groups.
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UK: Textiles Health And Safety Audit Package Launched Online
An Internet-based audit package to help textiles companies manage their health and safety risks has been launched by the Health and Safety Executive. The package, which is aimed at small and medium-sized firms, consists of a series of audit-style questions that help steer users through the control standards HSE inspectors use to measure a company's performance.
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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
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ALL >> Home-Based-Business >> View Article
Things To Consider When Buying Calgary Laminate Flooring
Total Articles: 6
Laminate floors are great for the Calgary homeowner who wants the look of hardwood, natural stone, or other designs. You can even opt to get textured laminate which resembles the real surfaces of stone or wood. The finished look of quality laminate flooring can be virtually undetectable when compared to the real thing. As more homeowners are opting for laminate flooring solutions throughout their home, there are a few points to consider that will help you make a more informed buying decision.
Price Differential
Since the decorative surface of basic laminate flooring is simply a photographic image, there isn't a large price difference between different styles of the floor. A marbled laminate will cost about the same as a light hardwood style. This is due to the fact that the manufacturing process is the same and isn't dependent on style, color, or type. You will find higher end laminates that require a great number of photographic layers, which can produce a more natural looking result. This higher end laminate flooring, along with texturized laminate, will cost a little more, but usually comes with longer warranties and are more durable than standard laminate. Otherwise, price differences only exist as a retailer determines their own in-store prices.
Most laminate floors are easy to install, and use a floating floor system. A padded underlayment lies on top of the subfloor, and then the laminate is installed above that. The planks get anchored to the edges of other planks, and are not secured to the subfloor. This can result in a hollow sound when walking on the laminate.
Using the laminate planks glue together on the sides with special adhesive, but some laminate floors come in planks that click together via a tongue and groove type system. This is beneficial if you need to repair a plank at some point, because it's really easy to pop it out and put a replacement in.
Total Cost of the Project
It's easy to just focus on the price of the laminate flooring when considering an appropriate budget. First, you want to figure out the cost per square foot for the actual flooring materials, and then ask the Calgary retailer if any additional costs will be needed to cover your whole flooring project. For example, are you planning to install it yourself or have a professional do it? Some installation companies will charge for extra services, like moving (and then replacing) furniture, disposing of old flooring, or sub floor preparation. If you're lucky, your new laminate floor may be able to be installed directly over your existing floor.
You should also inquire whether your Calgary retailer charges delivery fees, and make appropriate arrangements to get the laminate to your space. Also, include the cost of any additional materials you may need, like trim pieces. Installing Calgary laminate floor in your home can update your décor and give any room a warm and inviting look.
Author Bio:
The author is an enthusiastic entrepenuer dedicated to bringing the best in floors & flooring in Calgary area. With many years of experience in the flooring business, he provides as many options as possible at the Home Flooring Design Centre. He has expertise in laminate floors Calgary and the other various flooring options.
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Water dragged into Earth's interior helps melt rock, but near the Tonga trench there's the least magma where there's the most water. What is going on?
It was a bit like making a CT scan of a patient's head and finding he had very little brain or making a PET scan of a dead fish and seeing hot spots of oxygen consumption. Scientists making seismic images of the mantle beneath a famous geological site saw the least magma where they expected to see the most.
The Lau Basin, in the South Pacific (top), is a V-shaped basin created by the subduction of the Pacific Plate at the Tonga Trench (the purple line in the central image). A seismic image (bottom) of part of the basin at a depth of 50 kilometers (31 miles) shows magma pooling to the north beneath areas that are unrifted (dark red) and provide no egress but little magma (pale yellow) along the southern end of the Eastern Lau Spreading Center, or ELSC, even though this area is intensely volcanic.
What was going on? Was it an artifact of their technique or the revelation of something real but not yet understood?
In the online Feb. 2 issue of Nature, a team of scientists, led by S. Shawn Wei and Douglas Wiens of Washington University in St. Louis, published a three-dimensional seismic image of mantle beneath the Lau Basin in the South Pacific that had an intriguing anomaly.
The basin is an ideal location for studying the role of water in volcanic and tectonic processes. Because the basin is widening, it has many spreading centers, or deep cracks through which magma rises to the surface. And because it is shaped like a V, these centers lie at varying distances from the Tonga Trench, where water is copiously injected into Earth's interior.
The scientists knew that the chemistry of the magma erupted through the spreading centers varies with their distance from the trench. Those to the north, toward the opening of the V, erupt a drier magma than those to the south, near the point of the V, where the magma has more water and chemical elements associated with water. Because water lowers the melting temperature of rock, spreading centers to the north also produce less magma than those to the south.
Before they constructed images from their seismic data, the scientists expected the pattern in the mantle to match that on the surface. In particular they expected to find molten rock pooled to the south, where the water content in the mantle is highest. Instead the seismic images indicated less melt in the south than in the north.
They were flummoxed. After considerable debate, they concluded they were seeing something real. Water, they suggest, increases melting but makes the melt less viscous, speeding its transport to the surface, rather like mixing water with honey makes it flow quicker. Because water-laden magma flushes out so quickly, there is less of it in the mantle at any given moment even though more is being produced over time.
The finding brings scientists one step closer to understanding how the Earth's water cycle affects nearly everything on the planet — not just the clouds and rivers above the surface, but also processes that take place in silence and darkness in the plutonic depths.
Stretched thin and ripping
The Lau Basin, which lies between the island archipelagos of Tonga and Fiji, was created by the collision of the giant slab of the Pacific Ocean's floor colliding with the Australian plate. The older, thus colder and denser, Pacific plate nosed under the Australian plate and sank into the depths along the Tonga Trench, also called the Horizon Deep.
Water given off by the wet slab lowered the melting point of the rock above, causing magma to erupt and form a volcanic arc, called the Tonga-Kermadec ridge.
About 4 to 6 million years ago, the Pacific slab started to pull away from the Australian slab, dragging material from the mantle beneath it. The Australian plate's margin stretched, splitting the ridge, creating the basin and, over time, rifiting the floor of the basin. Magma upwelling through these rifts created new spreading centers.
"Leave it long enough," said Wei, a McDonnell Scholar and doctoral student in earth and planetary science in Arts & Sciences, "and the basin will probably form a new ocean."
"The Tonga subduction zone is famous in seismology," Wiens said, "because two-thirds of the world's deep earthquakes happen there and subduction is faster there than anywhere else in the world. In the northern part of this area the slab is sinking at about 24 centimeters (9 inches) a year, or nearly a meter every four years. That's four times faster than the San Andreas fault is moving."
The magma that wasn't there
The images of the mantle published in Nature are based on the rumblings of 200 earthquakes picked up by 50 ocean-bottom seismographs deployed in the Lau Basin in 2009 and 2010 and 17 seismographs installed on the islands of Tonga and Fiji.
The 2009-2010 campaign, led by Wiens, PhD, professor of earth and planetary sciences in Arts & Sciences, was one the largest long-term deployments of ocean-bottom seismographs ever undertaken (see video above).
When the scientists looked carefully at the southern part of the images created from their seismograph recordings, they were mystified by what they saw — or rather didn't see. In their color-coded images, the area along the southern end of the spreading center in the tip of the basin, called the ELSC, should have been deep red.
Instead it registered pale yellow or green, as though it held little magma. "It was the reverse of our expectation," Wei said.
To make these images, the scientists calculated the departure of the seismic velocities from reference values, Wei explained. "If the velocities are much lower than normal we attribute that to the presence of molten rock," he said. "The lower the velocity, the more magma."
Because water lowers melting temperatures, the scientists expected to see the lowest velocities and the most magma to the south, where the water content is highest.
Instead the velocities in the north were much lower than those in the south, signaling less magma in the south. This was all the more mystifying because the southern ELSC is intensely volcanic.
If the volcanoes were spewing magma, why wasn't it showing up in the seismic images?
After considerable debate, the scientists concluded that water from the slab must make melt transport more efficient as well as lowering melting temperatures.
"Where there's very little water, the system is not moving the magma through very efficiently," Wiens said. "So where we see a lot of magma pooled in the north, that doesn't necessarily mean there's a lot of melting there, just that the movement of the magma is slow."
"Conversely, where there's water, the magma is quickly and efficiently transported to the surface. So where we see little magma in the south, there is just as much melting going on, but the magma is moving through so fast that at any one moment we see less of it in the rock," Wiens said.
"The only way to explain the distribution of magma is to take account of the effect of water on the transport of magma," Wei said. "We think water makes the magma significantly less viscous, and that's why transport is more efficient."
"This is the first study to highlight the effect of water on the efficiency of magma extraction and the speed of magma transport," Wiens said.
Wei plans to continue following the water. "A recent paper in Nature described evidence that water is carried down to 410 kilometers (250 miles). I'd like to look deeper," he said.
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Diana Lutz | newswise
Further reports about: > Tonga > magma > mantle > molten rock > seismographs > velocities > volcanic
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HOUSTON – Don't start getting too excited about that Michael Bisping vs. Nick Diaz fight just yet. While you'll struggle to find someone to say they wouldn't be interested in seeing the two clash, UFC boss Dana White isn't convinced Diaz is planning a return to the sport.
"I love that fight," White said following today's pre-UFC 166 media session. "I love that fight. I like it, but everything I hear from Nick Diaz is that he doesn't want to fight."
Talk of the potential bout first surfaced earlier this week, after UFC 166 main-card competitor and Diaz teammate Gilbert Melendez said he expected the former Strikeforce champion would end his current retirement if a convincing offer came along.
Bisping (24-5 MMA, 14-5 UFC) was all to happy to throw his hat in the ring, tweeting, "Well if Diaz wants a fight at 185 I would happily welcome him to the division."
Diaz (26-9 MMA, 7-6 UFC), who's done most of career work at welterweight, retired in the cage following a title loss to Georges St-Pierre in March. Few in the industry, though, have taken Diaz's retirement too seriously. There was brief speculation about a new deal and though White recently offered him a fight with middleweight Lyoto Machida, Diaz has given no indication he's seriously contemplating a return to the cage.
And if things are any different behind the scenes, White isn't sharing. But he also isn't hiding his enthusiasm for a potential Bipsing vs. Diaz slugfest.
"I love that fight," White reiterated. "Fun fight."
For more on the UFC's upcoming schedule, check out the UFC Rumors section of the site.
(Pictured: Nick Diaz)view original article >>
Nick Diaz, come on man, everyone wants to see you fight again, especially Snoop Dogg... and he's got a 3-point plan to help you avert getting flagged for pot. read news >>
Al Iaquinta hadn't fought for two years until recently because he was disgruntled. He is now more upset with Dana White and the UFC than ever. read news >>
UFC president Dana White recently sat down to give some insight into what his life was like growing up. read news >>
The UFC sold this past July for about $4 billion, or $3.775 billion and a quarter-billion in earn-outs, if you want to get technical. But when the promotion's former owners were considering which buy read news >>
What's more surprising than the UFC having been purchased for $4.2 billion? How about the idea that there were two higher bidders that were shot down? read news >>
Everyone's got a fight story. Even UFC President Dana White has his share. Filed under: News, UFC read news >>
UFC President Dana White doesn't "even think about the money" he's made from the UFC's rise and recent sale, according to what he said in a recent interview. But while multimillionaires might have th read news >>
Photo by ?Ron Chenoy-USA TODAY Sports? Last year when Zuffa, LLC sold the UFC to Hollywood mega-talent agency WME|IMG for $4 billion—$3,998,000,000 more than Zuffa had paid for it just 15 years earli read news >>
When UFC was sold in July 2016 to WME-IMG for a staggering $4.2 billion, longtime president Dana White inked a five-year deal to remain with the fight company. read news >>
UFC president Dana White admits that he gives Conor McGregor more leeway than he does other fighters on the fight promotion's roster. read news >>


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Experience one of the biggest movie sagas of all time with the Jurassic Park Collection! From Academy Award-winning director Steven Spielberg (Jurassic Park, The Lost World: Jurassic Park), Joe Johnston (Jurassic Park III) and Colin Trevorrow (Jurassic World), dinosaurs once again roam the Earth in an amazing theme park on a remote island. The action-packed adventures find man up against prehistoric predators in the ultimate battle for survival. Featuring visually stunning imagery and groundbreaking filmmaking, these epic films are sheer movie-making magic which were 65 million years in the making. Welcome to Jurassic Park.
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Steven Spielberg is a very good movie director. You can safely go and view the movies he has done. These Jurassic Park movies are of excellent quality and entertainment for the whole family. There is enough action and suspense in the movies. The Special effects are marvelous. Over and over worthwhile watching. I bought this collection because I want to watch them again. Absolute highly recommended.
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Brilliant films and even better to watch them back to back. Definitely one to watch on a cold winters night.
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Sample Sale Easter Special @ Papillon Weddings
Come and take a look at our amazing sample sale from 13th - 20 the April. Our Easter gift to you is an extra 10% saving off all dresses purchased during this period.
Come and take a look at our amazing sample sale from 13th - 20 the April. Our Easter gift to you is an extra 10% saving off all dresses purchased during this period.
End of season Sample Sale @ The Fashaddict Shop.
Jacket: £30 Trousers: £20 Dress: £15 Top: £5
Designer sample gowns starting from £500. Up to 70% off.
Sizes: UK Size 12 with a few 10's and 14's
If you are looking for a designer wedding dress at a great price, look no further! Our Goodbye Collection dresses are discontinued and ex sample gowns. Most are in amazing condition and are genuine reductions from some of the UK's top designers – we simply need the room in store for the new girls in town! Most gowns are from current collections and reductions can represent savings ... Read more
Up to 70% off designer wedding dresses, bridesmaids, mother of the bride and prom dresses.
All dresses at least 50%
Sizes range from 8-16.
No appointment is necessary.
A Fantastic Wedding Dress Sample Sale with gowns by Emma Victoria Payne, Elie Saab and La Sposa Gowns from £500, Sizes 8-12 By Appointment Only
Beachwear sample sale of brands like L'Space and PilyQ
House of Holland sample sale at The Hoxton Holborn: Womenswear, menswear and accessories.
Signup for this event .
Don't miss out our sample sale this weekend! It's the perfect opportunity to get some Mother of Pearl pieces from previous collections at very special prices!
From 70% off previous collections, one off pieces and accessories.
Up to 90% off womenswear and accessories. Prices start from just £5.
We invite you to the Naomi Neoh Sample Sale at our Central London showroom in Pimlico. We will have a large selection of discontinued dresses and ex-samples to purchase. The Naomi Neoh team will be on hand to help find your perfect dress. ALL WORN SAMPLE DRESSES WILL £1,000 OR UNDER* Please bring only ONE guest with you.
You're invited to the Amanda Wakeley Bridal Sample Sale at our Fulham Road Bridal boutique. From Friday, April 7th until April 8th we're hosting an exclusive sample sale, with up to 80% OFF selected wedding dress samples. Available styles are traditionally fitted to a standard UK size 10-12, with a fitting service available upon request. If you would like to come along drop us an ... Read more


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I spent along time trying to find a hotel in Rome that had a central location and received good reviews on Trip Advisor and this was one of the few that came back with good reviews. It was a great choice. Central location for site seeing, close to station for trains and metro. The old fashioned lift made it vey quaint. We weren't expecting much for breakfast but we were pleasantly surprised by the choice and the staff were very accommodating if you wanted anything else. Free computers in reception, free wifi in the room. Only one thing that I would be negative about was the bathroom was quite small but apart from that a great stay.
- Official Description (provided by the hotel):
- Hotel Sonya is in a quiet area of central Rome, in front of the Opera House and 55 yards from the Viminale Palace. Rooms offer free internet and free Sky satellite TV. Rooms at the Sonya Hotel are air-conditioned and feature a private bathroom and a tea/coffee maker. Breakfast includes a variety of breads and pastries, cold cuts, fried eggs and fresh fruit. The Sonya is a 5-minute walk from Termini Train Station. Free maps of the city are available at the front desk with ticket-booking service. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Hotels.com, Ebookers, Agoda, Booking.com, Priceline, TripOnline SA, Traveltool, S.L.U., Cancelon, Evoline ltd and Hotel.de so you can book your Hotel Sonya reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.
- Also Known As:
- Sonya Hotel Rome


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Albany Police identify man killed in stabbing on Elk Street
Albany Police are investigating a stabbing on Elk Street that put a man in the hospital with multiple stab wounds early Saturday morning.
Sponsored by:
Albany Police are investigating a stabbing on Elk Street that put a man in the hospital with multiple stab wounds early Saturday morning.
A local community honored one of its own, who was taken too soon.
Cleanup is underway after thunderstorms hit the Capital Region on Thursday.
11th Hour Rescue: 518-223-5589
NEWS10 ABC talked about people driving too fast, now it's time to tackle the slow pokes!
The plan to transform an old hospital in Troy into affordable housing is drawing mixed reaction.
An emotional story of two local families battling the same heart-breaking addiction.
Eight months later and supporters are still fighting for justice for little Kaiden Starr Rice.
A milestone was reached Friday as the Erie Canal celebrates the 200th anniversary of the first dig on the trip west to Buffalo.
Union College broke ground Friday on a $100 million project. It's one of the most ambitious in the school's history.
Rotterdam Police are looking to identify two individuals they say was involved in a gang assault at the Blue Jay Tavern in March.
Saratoga Springs Mayor Joanne Yepsen announced on Friday she is not running for re-election.
Lavinia Kelly has remained in intensive care after she contracted botulism when she ate nacho cheese from a gas station's deli section in Ap…
Former U.S. Rep. Anthony Weiner has pleaded guilty to transmitting sexual material to a minor and could get years in prison.
It was the hottest day of the year so far, and it didn't cool down for the CDPHP Workforce Challenge.


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King is a red and white paint who has worked hayrides, weddings, and is saddle broke. He is a horse who has done and seen it all, but still has plenty…$1,800
2010 Bay, 13H Sport Pony Mare by GRP stallion Popeye, out of welsh cross mare. Registered, has her lifetime USEF, USHJA and USDF numbers, and micro chip…$2,900
"Luther" is a coming seven year old, dark bay gelding, imported from Ireland in the fall of 2015. He has fantastic gaits and a superb, uphill canter. …$15,000
at several different XC venues, playing with everything from 2 feet up through novice questions. She hacked$6,000
for just about anything INCLUDING trail riding and SAFE in traffic. And the bonus is...if perfectly trained$1,500
Luigi is a top class horse with loads of potential for eventing, dressage or hunters. Coming 7yr old, 16.1, 100% sound with xrays. Elastic gaits with potential…$7,500
is currently registered with the sugarbush draft registry, but qualifies to be registered as a Friesian Sport$12,500
buyer. Beau has done Dressage up to first level and has done some cross country training. He is able$23,500


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Explore Drinking Coffee, Love The and more!
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Rise and Shine! If you're drinking #coffee today, can you see yourself making it here? @janicesthomas makes a gorgeous, creamy wall of inset cabinetry - I love the furniture style feet and the open glass cabinetry up top. #kitchen #kbistakeover #dreamy #hgtvdesign #home
This is a wonderful blog. Love the built in pantry and coffee/breakfast station. http://1.bp.blogspot.com/-DCJ4K-kV-7Y/T-x0eT5t-FI/AAAAAAAAThE/e8v6pdwyGLE/s1600/IMG_0969.jpg
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Nar Fine Carpentry, Inc. Sacramento El Dorado Hills. Classic white kitchen. Glass panel backsplash in copper hue compliments the cabinet hardware and sculptural pendant.
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Legendary Motown performers of the 1960s, 1970s and 1980s reunite on stage to celebrate the silver anniversary of the greatest soul-pop sounds in music history. Saturday, May 27 at 10 PM
On Second Thought is a one-hour, daily news talk show that airs at 9 a.m. ET weekdays.
High-Demand careers in the Three Rivers area include manufacturing, logistics, and healthcare occupations.
The GHSA state championships for football are right around the corner. There are 16 teams left on the road to the Georgia Dome and by late Saturday night all eight champions for 2016 will be... MORE
GPB Passport is the new member benefit that provides you with extended access to an on-demand library of quality local and national public television programming, including tens of thousands of hours of your favorite programs.
A new report shows confidence among U.S. home builders has reached its highest level since late 2005.
The National Association of Home Builders/Wells Fargo builder sentiment index has jumped to 59...
Episode # 431
John Wieland
Founder and Chairman, John Wieland Homes and Neighborhoods
An icon in the home building industry... John Wieland's company is one of the south's leading home builders,...


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Vans Authentic K
Vans and Nintendo come together to celebrate the early days of video games with a truly unique collaboration featuring one-of-a-kind graphic prints. Showcasing 8-bit artwork of Nintendo's iconic characters, the Nintendo Authentic combines the original Vans low top style with an allover Princess Peach print, sturdy canvas uppers, metal eyelets, and custom GAME OVER signature rubber waffle outsoles.
- Composition: Textile
Do you want to know which other related running & triathlon products Vans has? At runnerinn, you can buy all the necessary Urban items so that you can benefit from your activities without complications. Vans Authentic K is at best price and in stock! Make us of our secure online payment system and benefit from our high qualified salesteam.
View more related products to:Vans - Kids´ shoes - Urban


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A Sydney teenager has pleaded guilty to planning a terror attack on Anzac day last year. (AAP file image)
A Sydney teenager has pleaded guilty to planning an Anzac Day terrorist attack last year.
The then 16-year-old boy was arrested in Auburn on April 24 last year, hours before packed-out dawn services started across the country to mark Anzac Day.
Previous court hearings, when he unsuccessfully applied for bail, were told prosecutors relied on transcripts of online conversations between the teenager and undercover police operatives in the days preceding Anzac Day.
The teenager was accused of using an encrypted message app to try and obtain a gun for an April 25 attack and, when that failed, a bomb manual.
He allegedly said he targeted April 25 "because here in Australia the kafir (non-Muslims) celebrate Anzac Day and I want to terrorise them on that day".
Prosecutors said the teen sent a text on April 16 stating: "I want to learn how to make a bomb."
The IS flag appeared in his messaging avatar.
The magistrate, who heard those submissions in May last year, refused him bail, saying it was too risky to release him.
Taking into account the fact he had been in a de-radicalisation program when he was arrested, she said there was a risk he would flee or strike out if released.
The teenager pleaded guilty to planning a terrorist act in Parramatta Children's Court this morning.
The parties are yet to agree on the facts and the boy was remanded in custody until the case returns to court, most likely on April 21.
© Nine Digital Pty Ltd 2017
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Our company is extremely involved in providing a comprehensive range of Wall and Roof Sandwich Panel to our valuable clients. This product is used in various residential as well as commercial sectors for specific purposes. The product offered by us is manufactured using superior grade raw material and progressive technology in adherence to the latest market norms. Apart from this, offered range is widely acknowledged among our prestigious clients for its durability.
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Career Center
Welcome to ICPAS Career Center
Junior Accountant
Gerald Bauman & Company, P.C.
Record financial transactions using QuickBooks and other proprietary software under senior accountant supervision.
Proof read financial statements
Verify mathematical accuracy of tax returns and financial statements
Assist and develop skills in performing bank reconciliations and other financial statement write up positions.
College degree
Internal Number: 01
About Gerald Bauman & Company, P.C.
4 person CPA firm located in Chicago's Magnificient Mile area
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Two Mike Rogers and reducing Edward Snowden's Profile.
NOW we have two Mike Rogers - the new NSA boss - and the old one who practices sneering in his mirror every day, the Congressman who is on an oversight committee and repeats his mantra of "Snowden is a traitor".
As if anyone is actually listening.
Obviously psychologists and their ilk have been consulted which accounts for the Navy man being so cool. Hardly matches Alexander's and Clapper's rhetoric.Perhaps they simply want to help Snowden sink below the parapet and lose his press following.
Whatever happens, this won't occur - Snowden has done everyone a big favour.
I was watching Enemy of the State, made in 1998, an American spy-thriller. If viewers had doubts about technology back then, now - 16 years later - we know what the NSA does.


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Chambre privée
2 voyageurs
1 chambre
1 lit
Chambre privée
2 voyageurs
1 chambre
1 lit
À propos de ce logement
This inner city character home is nestled in the heart of "Canada's Best Neighborhood 2015". Nearby attractons and amenities include some of Calgary's best restaurants, live music venues and The Home of the Calgary Flames, The Saddledome, all of which are minutes away.
Si vous annulez jusqu'à 24 heures avant le voyage, vous recevez un remboursement intégral, frais de service compris.
2 commentaires
Cet hôte a 1 commentaire pour d'autres propriétés.Voir d'autres commentaires
Hey there! My name is Mark. I'm a born Calgarian, avid traveller, amateur photographer and student.
I have a beautiful home located in the neighbourhood of Inglewood in Calgary. The community of Inglewood is right downtown and has two of Calgary's only music venues to play live music each and every night. There is also Calgary's longest running Farmers and Flea Market right in the neighborhood as well, a 15 min walk from the house. The river path, East Village, Calgary Zoo and a wide variety of dining or nightlife options are a 4 minute walk from the house.


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|By Business Wire
Article Rating:
|January 8, 2013 12:00 PM EST
CES BOOTH #1101 – Pioneer Electronics (USA) Inc. today expanded smartphone connectivity support for its AppRadio® platform of products with the introduction of new applications and the launch of its AppRadio Development Center (ADC), www.appradiodev.com, a site created for developers interested in making their apps compatible with Pioneer's lineup of AppRadio products.
Pioneer AppRadio 2 (Photo: Business Wire)
"There are now more than three dozen apps that are compatible with Pioneer's AppRadio platform. We are excited to work with many of the most popular services and app developers, like Clear Channel's iHeartRadio® and the winner of the 2012 South by Southwest (SXSW) App Hackathon, Eat the Road™, to deliver the latest and most in-demand content from the user's smartphone to the car," said Ted Cardenas, vice president of marketing for the Car Electronics Division of Pioneer Electronics (USA) Inc. "With the launch of the AppRadio Development Center, we are able to streamline the coordination between third-party app developers and Pioneer, reducing the time needed to establish compatibility between their apps designed for in-vehicle use and the Pioneer AppRadio platform, and ultimately increasing the number of AppRadio compatible apps in the future."
Pioneer's AppRadio platform of products includes two AppRadio products and eleven in-dash receivers integrated with the AppRadio Mode functionality (previously named Advanced App Mode), including eight multimedia DVD receivers and three navigation receivers.
New Apps, More Services
New apps being introduced at CES offer users services in a variety of categories including location based services (Beej!™, Glympse® and Parkopedia®), in-car browsing (Maxthon® Cloud Browser) and Internet Radio (Rdio® and iHeartRadio for Auto).
iHeartRadio for Auto (iHeartAuto™), Clear Channel's new all-in-one digital radio app specifically designed for use in-vehicle, offers a simple, safety-minded user-interface that provides seamless access to more than 1,500 live radio stations from across the country. iHeartAuto listeners can also create stations based on their favorite artists or songs, choosing from more than 15 million songs and the top live radio stations in America.
AppRadio Development Center
The new AppRadio Development Center will help grow the library of AppRadio apps, expediting the development process between Pioneer and third party in-vehicle app developers by providing the tools necessary for integrating their apps with the AppRadio platform. These tools include the software development kit, technical support, and additional resources to find all of the information necessary from a single central resource portal. The site will also allow developers to submit their apps for certification, a process that includes meeting Pioneer's AppRadio and Driver Distraction Guidelines. These guidelines have been created as a reference in the development of apps that are designed or modified specifically for in-vehicle use to promote safe use while driving.
To gain full access to the AppRadio Development Center, developers must first have their app(s) available for download from Google® Play or the Apple® App Store. Developers are encouraged to register their companies and apps on www.appradiodev.com to start the review process and help determine whether apps meet the AppRadio platform requirements. If a developer's app is eligible to be AppRadio compatible, then upon execution of a non-disclosure agreement, Pioneer will provide admission to the AppRadio Developer Program and access to Pioneer's Software Developer Kit (SDK) for integration with the developer's iOS or Android app(s). For more information, please visit www.appradiodev.com.
Pioneer Electronics (USA) Inc. is headquartered in Long Beach, Calif., and its U.S. Web address is www.pioneerelectronics.com. Its parent company, Pioneer Corporation, is a preeminent manufacturer of high-performance audio, video and computer equipment for the home, car and business markets and is celebrating 75 years of innovation in the consumer electronics industry.
For more information follow us on:
Twitter at twitter.com/PioneerUSA
Facebook at facebook.com/PioneerNorthAmerica
YouTube at youtube.com/pioneerelectronics
NOTE: Read the operation manual as well as all instructions and cautions provided with compatible smartphone apps before use. Become familiar with any applicable state and local laws. Pay attention to the road, limit glances to the device, and do not use any feature if it cannot be operated safely in your location and environment. Distracted driving may result in serious injury, including death.
Pioneer and AppRadio are registered trademarks of Pioneer Corporation.
Google, Google Play and Android are trademarks or registered trademarks of Google Inc.
Apple is a trademark of Apple Inc., registered in the U.S. and other countries.
iHeartRadio and iHeartAuto are trademarks of Clear Channel Broadcasting, Inc.
Eat the Road is a trademark of Objective App, LLC.
Parkopedia is a registered trademark of Parkopedia Limited.
Beej! is a trademark of ILS Technologies LLC.
Glympse is a registered trademark of Glympse Inc.
Maxthon is a registered trademark of Maxthon USA Inc.
Photos/Multimedia Gallery Available: http://www.businesswire.com/multimedia/home/20130108005148/en/
Everywhere we turn in our industry we can find strong opinions about the direction, type and nature of cloud's impact on computing and business. Another word that is used in every context in our industry is "hybrid." In his session at 20th Cloud Expo, Alvaro Gonzalez, Director of Technical, Partner and Field Marketing at Peak 10, will use a combination of a few conceptual props and some research recently commissioned by Peak 10 to offer a real-world consideration of how the various categories of...
May. 24, 2017 06:45 PM EDT Reads: 1,234
Five years ago development was seen as a dead-end career, now it's anything but – with an explosion in mobile and IoT initiatives increasing the demand for skilled engineers. But apart from having a ready supply of great coders, what constitutes true 'DevOps Royalty'? It'll be the ability to craft resilient architectures, supportability, security everywhere across the software lifecycle. In his keynote at @DevOpsSummit at 20th Cloud Expo, Jeffrey Scheaffer, GM and SVP, Continuous Delivery Busine...
May. 24, 2017 06:00 PM EDT Reads: 3,823
Detecting internal user threats in the Big Data eco-system is challenging and cumbersome. Many organizations monitor internal usage of the Big Data eco-system using a set of alerts. This is not a scalable process given the increase in the number of alerts with the accelerating growth in data volume and user base. Organizations are increasingly leveraging machine learning to monitor only those data elements that are sensitive and critical, autonomously establish monitoring policies, and to detect...
May. 24, 2017 05:30 PM EDT Reads: 1,029
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named "Gold Sponsor" of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer's customers range from Web startups to global enterprises.
May. 24, 2017 05:15 PM EDT Reads: 7,547
The 21st International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Machine Learning and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding busin...
May. 24, 2017 05:00 PM EDT Reads: 1,533
Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deli...
May. 24, 2017 04:15 PM EDT Reads: 5,181
SYS-CON Events announced today that Systena America will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Systena Group has been in business for various software development and verification in Japan, US, ASEAN, and China by utilizing the knowledge we gained from all types of device development for various industries including smartphones (Android/iOS), wireless communication, security technology and IoT serv...
May. 24, 2017 04:00 PM EDT Reads: 766
SYS-CON Events announced today that Loom Systems will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Founded in 2015, Loom Systems delivers an advanced AI solution to predict and prevent problems in the digital business. Loom stands alone in the industry as an AI analysis platform requiring no prior math knowledge from operators, leveraging the existing staff to succeed in the digital era. With offices in S...
May. 24, 2017 03:45 PM EDT Reads: 5,478
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend @CloudExpo | @ThingsExpo, June 6-8, 2017, at the Javits Center in New York City, NY and October 31 - November 2, 2017, Santa Clara Convention Center, CA. Learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
May. 24, 2017 03:30 PM EDT Reads: 5,394
SYS-CON Events announced today that EARP Integration will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. EARP Integration is a passionate software house. Since its inception in 2009 the company successfully delivers smart solutions for cities and factories that start their digital transformation. EARP provides bespoke solutions like, for example, advanced enterprise portals, business intelligence systems an...
May. 24, 2017 02:45 PM EDT Reads: 1,522
We build IoT infrastructure products - when you have to integrate different devices, different systems and cloud you have to build an application to do that but we eliminate the need to build an application. Our products can integrate any device, any system, any cloud regardless of protocol," explained Peter Jung, Chief Product Officer at Pulzze Systems, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA
May. 24, 2017 02:30 PM EDT Reads: 5,554
SYS-CON Events announced today that Enzu will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY, and the 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Enzu's mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive ad...
May. 24, 2017 01:45 PM EDT Reads: 4,430
Existing Big Data solutions are mainly focused on the discovery and analysis of data. The solutions are scalable and highly available but tedious when swapping in and swapping out occurs in disarray and thrashing takes place. The resolution for thrashing through machine learning algorithms and support nomenclature is through simple techniques. Organizations that have been collecting large customer data are increasingly seeing the need to use the data for swapping in and out and thrashing occurs ...
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SYS-CON Events announced today that Interoute has been named "Bronze Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Interoute is the owner operator of Europe's largest network and a global cloud services platform, which encompasses over 70,000 km of lit fiber, 15 data centers, 17 virtual data centers and 33 colocation centers, with connections to 195 additional partner data centers. Our full-service Unifie...
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DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm.
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SYS-CON Events announced today that delaPlex will exhibit at SYS-CON's @CloudExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. delaPlex pioneered Software Development as a Service (SDaaS), which provides scalable resources to build, test, and deploy software. It's a fast and more reliable way to develop a new product or expand your in-house team.
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SYS-CON Events announced today that Progress, a global leader in application development, has been named "Bronze Sponsor" of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Enterprises today are rapidly adopting the cloud, while continuing to retain business-critical/sensitive data inside the firewall. This is creating two separate data silos – one inside the firewall and the other outside the firewall. Cloud ISVs oft...
May. 24, 2017 01:15 PM EDT Reads: 3,586
SYS-CON Events announced today that WineSOFT will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Based in Seoul and Irvine, WineSOFT is an innovative software house focusing on internet infrastructure solutions. The venture started as a bootstrap start-up in 2010 by focusing on making the internet faster and more powerful. WineSOFT's knowledge is based on the expertise of TCP/IP, VPN, SSL, peer-to-peer, mob...
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SYS-CON Events announced today that Carbonite will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Carbonite protects your entire IT footprint with the right level of protection for each workload, ensuring lower costs and dependable solutions with DoubleTake and Evault.
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SYS-CON Events announced today that Ocean9will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Ocean9 provides cloud services for Backup, Disaster Recovery (DRaaS) and instant Innovation, and redefines enterprise infrastructure with its cloud native subscription offerings for mission critical SAP workloads.
May. 24, 2017 12:45 PM EDT Reads: 6,085


text: Home Gallery Video Dish Talk Boston With Paul Pierce DISH Will Teach You How to 'Talhk' Like You're From 'Bah-Stan' Paul Pierce Teaches You New Vocab Published on Jul 29, 2013 Editor's Pick DISH has been pushing the hilarious "Boston Boys" at us for quite a while. Now, the company is inviting you to get in on the act with a new campaign that teaches you to talk like you're from Boston. The site features vocab lessons, a test (what's the "Gahbidge"?) a Tweet translator and videos, like this one featuring Paul Pierce (who just happens to have left the Boston Celtics for the Brooklyn Nets) Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateJul 29, 2013Client:Dish CategoryTVCWebsite Latest Creativity News on Ad Age Watch the Newest Ads on TV From Ford, FedEx, Target and More Sean Smith Joins Solve, Anomaly London Adds Creative Directors Depeche Mode Turns Over Its Facebook Page to Fans -- for an Entire Year Related work Dish: Fiddler Dish: Shower Camp + King Dish: Dish Case Study Gravity


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Both a framed work of art and a finicky antique cannon add a lot of personality to a living room at the simple expense of a few holes in the wall. Maximize aesthetics while minimizing structural damage with this Groupon.
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All options come fully assembled with glass and backing. Frame pricing determined by customization; additional framing components such as mats, fillets, and UV glass may be added for an extra fee. Select mats are available for $20 per layer with this Groupon (regularly $30—$59). Customers are advised that options are only available up to the size listed; for framing items larger than listed size, customers should choose the larger option.
This Groupon is valid towards 20 different preselected frames, many of which can be seen in this deal's image.
Framed by Kosal
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Customer Reviews
150 Main St.
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+12032612552Get Directions


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Mustangs' "Waterhole Walk"
The horses in Nevada's northern high desert have a social structure much like ours. Likewise they are creatures of habit, which tend to centralize around food, water and sex – much like us to be sure as well. But unlike most of us, it is the water that drives their daily lives. Scarcity of water is an ever pressing dilemma as temperatures rise globally and droughts expand...
Captured with: nikon d700, 400mm @ f/5.6, 1/400, ISO 200. Sunrise ridge line walk to the only water hole in miles for these northern Nevada mustangs. Hit the "L" key for a better view!
1,118 views
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Taken on September 3, 2011


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Japan: Yakuza strip down to unveil full-body tattoos at rowdy Sanja festival
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By: Ruptly | Comments: 22 | Views: 2404 | Votes: 0 | Shared: 0
Location: Taito, Tokyo, Japan | Leaked: 4 days ago in Other
Robert Hight makes the FASTEST pass in NHRA history
337.66 mph in 1,000 feet!
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Location: Topeka, Kansas, United States | Leaked: 4 days ago in Sports, Vehicles
- US STRATEGY - ISLAMIC STATE ENDGAME - MAD DOG Mattis said Friday that Trump approved a recommendation for a "tactical shift" toward surrounding IS militants in their strongholds, such
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Psychopaths (Crime Psychology Documentary) - Real Stories
Psychopaths (Crime Psychology Documentary) - Real Stories 1 in 200 people in the UK are psychopaths?
By: Data1111 | Comments: 6 | Views: 633 | Votes: 1 | Shared: 0
Location: United States | Leaked: 4 days ago in Other Entertainment, Other
You don't want to miss a thing, Netanyahu tells Aerosmith
Prrime Minister Benjamin Netanyahu met with members of the rock band Aerosmith on Thursday, joking that they "don't wan't to miss a thing" during their Israel trip. Steven Tyler, Joe Perry, B
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Location: Jerusalem, Jerusalem, Israel | Leaked: 4 days ago in Other News
State Pays $3M To Settle Lawsuit In Fatal Shooting Case
Santa Fe, NM - State government agreed to a $3 million settlement payment to the family of a woman shot and killed by a State Police officer in Santa Fe more than three years ago to avoid a wrongful d
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Location: Santa Fe, New Mexico, United States | Leaked: 4 days ago in Other News, WTF
Palestinians riot in 'day of rage' - 2 seriuosly injured
Multiple Palestinian riots took place throughout the West Bank and Gaza Strip on Friday. Dozens of Palestinians were injured by crowd-dispersion measures taken by the IDF, two of them were badly inju
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Leaked: 4 days ago in Other News, Other Middle East
Boyfriend attacks two men after they cat-call his girlfriend
An enraged boyfriend attacked two men drinking outside an Inwood market after they cat-called and whistled at his girlfriend. Surveillance video released by police shows the man lunge forward and d
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Location: New York, New York, United States | Leaked: 5 days ago in Other News
Woman falls on subway tracks
A young Boston woman who fell onto the tracks at South Station early Wednesday evening said she was hot and fainted. Good Samaritans jumped in to help, and while she was reluctant to move, she reme
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How to fish a Ox
Great day fishing, fits all inside the fish's mouth.The fish lake monster. They say that it has Length of 2,30 meters, 1,00 meters of belly "3mts of head, haha "
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Moron driving a bus full with schoolchildren
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YP - The Real Yellow PagesSM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you might use to determine which business to select from a local Yellow Pages directory, including proximity to where you are searching, expertise in the specific services or products you need, and comprehensive business information to help evaluate a business's suitability for you. "Preferred" listings, or those with featured website buttons, indicate YP advertisers who directly provide information about their businesses to help consumers make more informed buying decisions. YP advertisers receive higher placement in the default ordering of search results and may appear in sponsored listings on the top, side, or bottom of the search results page.
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4540 Osage Beach Pkwy
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0.57 mi
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2.03 mi
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|By PR Newswire
Article Rating:
|January 22, 2013 06:00 PM EST
MELBOURNE, Australia, Jan. 22, 2013 /PRNewswire/ -- Australian biopharmaceutical company Specialised Therapeutics Australia announces that a phase III clinical trial of world leading breast cancer drug ABRAXANE® (nanoparticle albumin-bound paclitaxel) in combination with current standard of care gemcitabine in patients with advanced pancreatic cancer has demonstrated substantially improved survival times, with double the number of patients surviving two years.1
The MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) investigation involved 861 treatment naïve patients internationally.
Researchers found those patients treated with ABRAXANE plus gemcitabine had a statistically significant improvement in overall survival compared to patients receiving gemcitabine alone [(median of 8.5 vs. 6.7 months) (HR 0.72, P=0.000015)].1
Moreover, ABRAXANE plus gemcitabine demonstrated a 59% increase in one-year survival (35% vs. 22%, p=0.0002) and demonstrated double the rate of survival at two years (9% vs. 4%, p=0.02) as compared to gemcitabine alone.1
ABRAXANE plus gemcitabine also demonstrated statistically significant improvements in key secondary endpoints compared to gemcitabine alone, including a 31% reduction in the risk of progression or death with a median progression-free survival (PFS) of 5.5 vs. 3.7 months (HR 0.69, P=0.000024) and an overall response rate (ORR) of 23% compared to 7% (response rate ratio of 3.19, p=1.1 x 10-10). Another endpoint assessed included time to treatment failure, which was significantly improved with the ABRAXANE combination compared to gemcitabine alone [(median 5.1 vs. 3.6 months) (HR 0.70, P<0.0001)].1
"The past few decades have brought us very few treatment advances for patients with advanced pancreatic cancer, which is both deadly and incredibly difficult to treat with success," said Daniel D. Von Hoff, M.D., F.A.C.P., Lead Principal Investigator of the MPACT study and Chief Scientific Officer for Scottsdale Healthcare's Virginia G. Piper Cancer Centre Clinical Trials and Physician-In-Chief for TGen. "The fact that ABRAXANE plus gemcitabine demonstrated an overall survival benefit, and also did so at one and two years, is a significant step forward in offering potential new hope for our patients."
Professor John Zalcberg, Chief Medical Officer and Executive Director of Cancer Medicine at the Peter MacCallum Cancer Centre in Melbourne, said the evidence strongly supported using ABRAXANE in combination with gemcitabine as a new standard of care to treat appropriate patients, many of whom were not diagnosed until the disease was metastatic.
While acknowledging that this advance could not be seen as a cure for pancreatic cancer, Professor Zalcberg said the 59% increase in the number of patients who lived beyond 12 months was very encouraging.
"We are extremely encouraged by the results of this study involving ABRAXANE and regard this outcome as a significant breakthrough in terms of the future management of this disease," he said.
"In addition to treating women with metastatic breast cancer with ABRAXANE in the appropriate setting, we look forward to its approval in Australia for treating patients with advanced pancreatic cancer."
Specialised Therapeutics Australia (STA) Chief Executive Officer Mr. Carlo Montagner said the positive data paved the way for Australian patients with advanced pancreatic cancer to access more effective treatment options.
He commented: "In Australia, pancreatic cancer is the fourth most common cause of death from cancer for both men and women2 and very few treatment options exist for this group of patients. We are extremely pleased to demonstrate that ABRAXANE is capable of prolonging survival for patients with advanced pancreatic cancer and we hope to have ABRAXANE approved by the Australian Therapeutic Goods Administration (TGA) in the latter half of 2014."
The most common grade ≥ 3 treatment-related adverse events in the study for ABRAXANE plus gemcitabine vs. gemcitabine alone were neutropenia (38% vs. 27%), fatigue (17% vs. 7%), and neuropathy (17% vs. 1%). In the ABRAXANE plus gemcitabine arm, the median time to neuropathy improvement was 29 days. There was no difference in serious life threatening toxicity (4% in each arm).1
Further details of the study will be highlighted in a late-breaking oral presentation by Dr. Daniel D. Von Hoff:
- Abstract: LBA #148: Final results of a randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas. Friday, January 25th between 2:00 to 3:30 pm PST at the American Society of Clinical Oncology's (ASCO) 2013 Gastrointestinal Cancers Symposium in San Francisco, CA.
These results are from an investigational study. ABRAXANE is not approved for the treatment of advanced pancreatic cancer. Following TGA review and approval, STA will seek to have ABRAXANE included on the Pharmaceutical Benefits Scheme (PBS) for the reimbursement of ABRAXANE for advanced pancreatic cancer.
About the MPACT Study1
In the MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) study, a Celgene-sponsored, open-label, randomised, international study of 861 patients with metastatic pancreatic cancer were randomised to receive either ABRAXANE plus gemcitabine (125 mg/m2 followed by 1000 mg/m2 gemcitabine for 3 weeks followed by a week of rest) or gemcitabine alone (1000 mg/m2 administered weekly for 7 weeks followed by a week of rest followed by cycles of weekly administration for 3 weeks followed by one week of rest).
The primary endpoint for the study is improvement in overall survival. Secondary endpoints were progression-free survival, and overall response rate determined by independent radiological review. Other endpoints included progression-free survival, overall response rate determined by investigator and the safety and tolerability of this combination in this patient population.
About Advanced Pancreatic Cancer
Advanced pancreatic cancer is a difficult-to-treat cancer with the lowest survival rates among all cancer types. Across all patients with pancreatic cancer, relative 5-year survival is 6% and is less than 2% for those with advanced disease. There are two main types of pancreatic cancer - adenocarcinomas, which accounts for approximately 90% of all pancreatic cancer, and neuroendocrine tumors. Pancreatic cancer is relatively uncommon with new cases accounting for only 2.1% of all newly diagnosed cancers. However, pancreatic cancer is the fourth most common cause of cancer death for men and women in the United States and Australia, and the ninth most commonly diagnosed cancer in Australia.2
About ABRAXANE®
ABRAXANE is a solvent-free, nanoparticle chemotherapy treatment option for metastatic breast cancer.3 In Australia, ABRAXANE is currently listed on the PBS for the treatment of metastatic breast cancer and HER2 positive breast cancer in combination with trastuzumab.
ABRAXANE is approved for metastatic breast cancer in over 40 countries including the U.S., Canada, European Union, Japan and China, and more than 500,000 cancer patients have received ABRAXANE therapy in the past five years.
In Australia, ABRAXANE has been granted orphan drug designation by the Therapeutic Goods Administration for the treatment of pancreatic cancer. Orphan drug status is granted to drugs used to treat relatively rare diseases such as pancreatic cancer and may allow for priority evaluation by the TGA.
ABRAXANE is currently in various stages of investigation for the treatment of the following cancers: metastatic melanoma, bladder, ovarian, and expanded applications for breast cancer.
Developed using the proprietary nab™ technology platform, ABRAXANE is a nanoparticle protein-bound chemotherapy agent. ABRAXANE combines paclitaxel with albumin, a naturally-occurring human protein, to deliver the drug and eliminates the need for solvents in the administration process. Nanoparticle technology allows ABRAXANE to deliver a 49% higher dose compared to regular solvent-based paclitaxel without compromising safety and tolerability.3-4
In a randomised phase III study of metastatic breast cancer patients, ABRAXANE demonstrated nearly double the overall tumour response rate compared to solvent-based paclitaxel. 3-4
Anthracycline pre-treated patients in the study lived significantly longer.5 The tolerability with ABRAXANE and solvent-based paclitaxel was comparable, despite the 49% greater dose of paclitaxel administered as ABRAXANE.3-4 Neutropenia was lower with ABRAXANE compared to solvent-based paclitaxel, although there was an increase in incidence of grade 3 peripheral neuropathy with ABRAXANE. However the median time to improvement, from grade 3 peripheral neuropathy to grade 2 or lower, was 22 days. No adverse events were reported that were not already known for paclitaxel.3-4
Contraindications and side effects3:
Like all medications, ABRAXANE may cause side effects.
ABRAXANE should not be used in patients who have baseline neutrophil counts of <1.5 x 109 /L.
In patients who have exhibited hypersensitivity reactions to paclitaxel or albumin, patients should not be treated with ABRAXANE.
ABRAXANE is contraindicated during pregnancy and lactation.
Most common side effects (≥1/10) caused by ABRAXANE include; neutropenia, anemia, leucopenia, thrombocytopenia, lymphophenia, anorexia, peripheral neuropathy, hypoaesthesia, paraethesia, nausea, diarrhoea, vomiting, constipation, stomatitis, alopecia, rash, arthralgia, myalgia, fatigue, asthenia, pyrexia.
For further information regarding ABRAXANE and potential side effects, physicians should review the ABRAXANE Product Information and patients should consult their oncologist or the ABRAXANE Consumer Medicine Information available on www.specialisedtherapeutics.com.au.
ABRAXANE® is a registered trademark of Celgene Corporation.
ABRAXANE® is distributed by STA under license from Celgene Corporation in Australia and New Zealand.
About Specialised Therapeutics Australia Pty Ltd
Specialised Therapeutics Australia Pty Ltd (STA) is a biopharmaceutical company dedicated to working with leading pharmaceutical companies worldwide to provide acute care therapies for high unmet medical needs to people living in Australia and New Zealand.
Currently STA markets two world leading cancer and cancer supportive care therapies, ABRAXANE® (nab-paclitaxel) and ALOXI® (palonosetron HCl) respectively, and has recently licensed two new agents from the Helsinn Group. Firstly Anamorelin, which is a novel ghrelin receptor agonist for the treatment of anorexia-cachexia in NSCLC, and a fixed-dose combination product (in both oral and intravenous forms) containing netupitant, a neurokinin-1 (NK1) receptor antagonist, combined with Aloxi, a serotonin-3 (5-HT3) receptor antagonist. STA also has interests in the therapeutic areas of anti-infectives with the rights to commercialise DIFICID® (fidaxomicin) for the treatment of Clostridium difficile infections, respiratory, dermatology, endocrinology and central nervous system (CNS). Additional information can be found at www.specialisedtherapeutics.com.au
- Von Hoff DD et al. Abstract: LBA #148: Final results of a randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas. ASCO GI 2013
- Cancer in Australia. An Overview 2012. Australian Institute of Health and Welfare (AIHW)
- Abraxane Product Information
- Gradishar WJ et al. J Clinical Oncology 2005;23:7794-7803
- Vukelja SJ et al. ASCO 2008, Abstract 1082
Media Inquiries:
Emma Power
Monsoon Communications
Level 12 15 William Street
Melbourne VIC 3000
Ph: +61-3-9620-3333
SOURCE Specialised Therapeutics Australia Pty Ltd
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