text:
Data Processing Procedures and Methodology for Estimating Trip Distances for the 1995 American Travel Survey (ATS)
Hwang, H.-L.; Rollow, J.
The 1995 American Travel Survey (ATS) collected information from approximately 80,000 U.S. households about their long distance travel (one-way trips of 100 miles or more) during the year of 1995. It is the most comprehensive survey of where, why, and how U.S. residents travel since 1977. ATS is a joint effort by the U.S. Department of Transportation (DOT) Bureau of Transportation Statistics (BTS) and the U.S. Department of Commerce Bureau of Census (Census); BTS provided the funding and supervision of the project, and Census selected the samples, conducted interviews, and processed the data. This report documents the technical support for the ATS provided by the Center for Transportation Analysis (CTA) in Oak Ridge National Laboratory (ORNL), which included the estimation of trip distances as well as data quality editing and checking of variables required for the distance calculations.
SU-E-T-545: MLC Distance Travelled as a Predictor for Motor Failure
Stathakis, S; Defoor, D; Linden, P; Kirby, N; Papanikolaou, N; Mavroidis, P
Purpose: To study the frequency of Multi-Leaf Collimator (MLC) leaf failures, investigate methods to predict them and reduce linac downtime. Methods: A Varian HD120 MLC was used in our study. The hyperterminal MLC errors logged from 06/2012 to 12/2014 were collected. Along with the hyperterminal errors, the MLC motor changes and all other MLC interventions by the linear accelerator engineer were recorded. The MLC dynalog files were also recorded on a daily basis for each treatment and during linac QA. The dynalog files were analyzed to calculate root mean square errors (RMS) and cumulative MLC travel distance per motor. An in-house MatLab code was used to analyze all dynalog files, record RMS errors and calculate the distance each MLC traveled per day. Results: A total of 269 interventions were recorded over a period of 18 months. Of these, 146 included MLC motor leaf change, 39 T-nut replacements, and 84 MLC cleaning sessions. Leaves close to the middle of each side required the most maintenance. In the A bank, leaves A27 to A40 recorded 73% of all interventions, while the same leaves in the B bank counted for 52% of the interventions. On average, leaves in the middle of the bank had their motors changed approximately every 1500m of travel. Finally, it was found that the number of RMS errors increased prior to an MLC motor change. Conclusion: An MLC dynalog file analysis software was developed that can be used to log daily MLC usage. Our eighteen-month data analysis showed that there is a correlation between the distance an MLC travels, the RMS and the life of the MLC motor. We plan to use this tool to predict MLC motor failures and with proper and timely intervention, reduce the downtime of the linac during clinical hours.
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Careers, Jobs » Employee, Retiree Resources » Travel Reimbursement » Guest Travel Guest Travel Travel reimbursement process information for official Laboratory guests Contact Travel Office (505) 667-4138 Guest travel reimbursements Guest travel reimbursements are calculated based on federal travel regulations and LANL travel reimbursement policy. For special circumstances, government employee reimbursements, and other questions, call the Laboratory's Travel Office at (505) 667-4138. Before
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Careers » Employee, Retiree Resources » Travel Reimbursement » Interview Travel Interview Travel Travel preapproval and reimbursement process information for invited Laboratory job interviewees. Contact Travel Reservations (505) 667-1692 Email Student Travel (505) 667-5859 Interview travel process Interview travel will be reimbursed only when a Laboratory organization has invited a candidate to come to the Laboratory to interview for a specific job and the following process is used. Eligible
Schroeder, Alex
The Connected Traveler project is a multi-disciplinary undertaking that seeks to validate potential for transformative transportation system energy savings by incentivizing efficient traveler behavior. This poster outlines various aspects of the Connected Traveler project, including market opportunity, understanding traveler behavior and decision-making, automation and connectivity, and a projected timeline for Connected Traveler's key milestones.
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Careers, Jobs » Employee, Retiree Resources » Travel Reimbursement » Relocation Travel Relocation Travel Travel reimbursement process information for relocations including new regular hires, term assignment hires, post-doctoral or advance study employees, and long-term visiting staff members. Contact Gloria Salazar Relocation Office (505) 665-4484 Email Sher Robinson (505) 665-8529 Relocation travel process Reimbursement for travel includes new regular hires, term assignment hires,
Solar Decathlon: How far did they travel? | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Decathlon Journeys Visualizing the distances that each Solar Decathlon house travelled Click competitors to toggle their journeys on and off. All routes and distances are...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel Travel The Office of Travel Management serves as the Department's POC for the following services: Headquarters Travel Management Center (TMC) Official Travel, Domestic and Foreign Foreign Travel Management System (FTMS) Official Travel Regulations and Guidelines U.S. Passports and Visa Services (Official and Diplomatic) Non-Refundable Airfare Guidance International Insurance for DOE Officials (MEDEX) Car Rental Hotel Reservations Travel FAQs For questions about Travel Services or the
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Travel Travel The Office of Travel Management serves as the Department's POC for the following services: Headquarters Travel Management Center (TMC) Official Travel, Domestic and Foreign Foreign Travel Management System (FTMS) Official Travel Regulations and Guidelines U.S. Passports and Visa Services (Official and Diplomatic) Non-Refundable Airfare Guidance International Insurance for DOE Officials (MEDEX) Car Rental Hotel Reservations Travel FAQs For questions about Travel Services or the
JLab Travelers and Travel Coordinators: Effective Immediately...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
information could result in denial of country clearance and jeopardize future travel. ... All FTMS Travel Requisitions and Electronic Country Clearance (eCC) requests must be ...
Graduate, Undergraduate Student Travel
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Careers » Employee, Retiree Resources » Travel Reimbursement » Graduate, Undergraduate Travel Graduate, Undergraduate Student Travel Travel reimbursement process information for participants in the Graduate Research Assistant (GRA) and Undergraduate Student (UGS) programs Contact Travel Reservations (505) 667-1692 Email Student Travel (505) 667-5859 Email Graduate, undergraduate student travel process Travel by employees who participate in the Graduate Research Assistant (GRA) and
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Demand Modeler, Cambridge Systematics, Tallahassee, FL Abstract ... Travel demand ... Ahmed Mohideen Travel Demand Modeler Cambridge Systematics, Tallahassee, FL Transportation ...
On-Line Travel Reservations through "Concur Travel" | The Ames...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
them as a travel administrator. Travel will not be booked on Concur Travel until Ames Lab Travel Worksheet has been received and reviewed by the Travel Office. Concur Travel is...
Relocation Travel FAQs Travel/Moving FAQs
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Relocation Travel FAQs Travel/Moving FAQs When may I begin making travel and moving arrangements? No arrangements should be made prior to receiving a written offer of employment from Human Resources (HR) Division. The written offer letter is the official offer. The offer of employment must be accepted in writing (a signature on the offer letter) and returned to the Laboratory before making any travel or moving arrangements. How will I receive the relocation information? The relocation
Interviewee Travel Regulations Scope
U.S. Department of Energy (DOE) - all webpages (Extended Search)
232012 Interviewee Travel Regulations Scope These regulations apply to the reimbursement of round-trip travel expenses incurred by interviewees. These regulations do not apply to ...
Measurement of the direct -violating parameter in the decay
Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.
We measure the direct
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The Order supplements the Federal Travel Regulation as principal source of policy for Federal employee travel and relocation and establishes DOE M 552.1-1A, U.S. Department of Energy Travel Manual, dated 2-17-06, as the repository for supplementary travel requirements information. Supersedes DOE O 552.1A Chg 1 (Admin Chg), dated 10-1-08
Travel Policy | The Ames Laboratory
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Policy Travel Policy Travel Policy for Contractor Personnel Travel Policy Changes October 1, 2009 Per Diem Adjustments for Meals Memo or EXAMPLE
Travel Requirements - ITER (June 2014
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel Requirements - ITER (June 2014) Prior to any travel under this subcontract, the ... approval, with a copy to the identified US ITER Project Office Travel Administrative ...
Directives, Delegations, and Other Requirements [Office of Management (MA)]
To supplement the Federal Travel Regulation (41 CFR, Parts 300-304), the principal source of policy for Federal employee travel and relocation matters, and to establish DOE M 552.1-1, U.S. Department of Energy Travel Manual, dated 09-04-02, as the repository for supplementary travel requirements information for the Department of Energy (DOE). Cancels DOE 1500.2A and DOE 1500.4A. Canceled by DOE O 552.1A.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The Order supplements the Federal Travel Regulation as principal source of policy for Federal employee travel and relocation and establishes DOE M 552.1-1A, U.S. Department of Energy Travel Manual, dated 2-17-06, as the repository for supplementary travel requirements information. Supersedes DOE O 552.1. Admin Chg 1, dated 10-1-08, supersedes DOE O 552.1A.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The Order supplements the Federal Travel Regulation as principal source of policy for Federal employee travel and relocation and establishes DOE M 552.1-1A, U.S. Department of Energy Travel Manual, dated 2-17-06, as the DOE repository for supplementary travel requirements information. Cancels DOE O 552.1-1. Canceled by DOE O 552.1A Admin Chg 1.
JLab Travelers and Travel Coordinators: Effective Immediately - Critical
U.S. Department of Energy (DOE) - all webpages (Extended Search)
new requirements for all travel to or passing through France | Jefferson Lab Travelers and Travel Coordinators: Effective Immediately - Critical new requirements for all travel to or passing through France JLab Travelers and Travel Coordinators: Effective Immediately - Critical new requirements for all travel to or passing through France Due to increased security levels in France, it is critical for the U.S. State Department / Embassy of Paris to have the ability to quickly and directly
Directives, Delegations, and Other Requirements [Office of Management (MA)]
To establish Department of Energy (DOE) and National Nuclear Security Administration (NNSA) requirements and responsibilities governing official foreign travel by Federal and contractor employees. The Page Change 1 to the CRD issued 11-8-02, will expand the requirements for country clearance for contractors to include all official foreign travel, including travel to nonsensitive countries. Cancels DOE O 551.1. Canceled by DOE O 551.1B.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The Order sets forth requirements and responsibilities governing official foreign travel by Federal and contractor employees. Cancels DOE O 551.1B.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The order establishes requirements and responsibilities governing official foreign travel by Federal and contractor employees. Cancels DOE O 551.1C.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The order establishes DOE requirements and responsibilities governing official foreign travel by Federal and contractor employees. The Pg Chg removes the requirement to surrender official passports and replaces it with a process that requires travelers be responsible for safeguarding theirown official passports. Supersedes DOE O 551.1D, dated 4-12-12.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The order establishes DOE requirements and responsibilities governing official foreign travel by Federal and contractor employees. The proposed revisions to the Official Foreign Travel Order align it with established leave policy and update organizational responsibilities. Supersedes DOE O 551.1D Chg 1 (Pg Chg).
Accounting Techinican (Travel Duties)
This position may be filled either at Morgantown, WV or Pittsburgh, PA. A successful candidate in this position will provide technical accounting support to the travel program at the National...
Hietala, Vincent M.; Vawter, Gregory A.
The traveling-wave photodetector of the present invention combines an absorptive optical waveguide and an electrical transmission line, in which optical absorption in the waveguide results in a photocurrent at the electrodes of the electrical transmission line. The optical waveguide and electrical transmission line of the electrically distributed traveling-wave photodetector are designed to achieve matched velocities between the light in the optical waveguide and electrical signal generated on the transmission line. This velocity synchronization provides the traveling-wave photodetector with a large electrical bandwidth and a high quantum efficiency, because of the effective extended volume for optical absorption. The traveling-wave photodetector also provides large power dissipation, because of its large physical size.
Hietala, V.M.; Vawter, G.A.
The traveling-wave photodetector of the present invention combines an absorptive optical waveguide and an electrical transmission line, in which optical absorption in the waveguide results in a photocurrent at the electrodes of the electrical transmission line. The optical waveguide and electrical transmission line of the electrically distributed traveling-wave photodetector are designed to achieve matched velocities between the light in the optical waveguide and electrical signal generated on the transmission line. This velocity synchronization provides the traveling-wave photodetector with a large electrical bandwidth and a high quantum efficiency, because of the effective extended volume for optical absorption. The traveling-wave photodetector also provides large power dissipation, because of its large physical size. 4 figures.
Accounting Technician (Travel Duties)
This position may be filled either at Morgantown, WV or Pittsburgh, PA. A successful candidate in this position will provide technical accounting support to the travel program at the National...
Directives, Delegations, and Other Requirements [Office of Management (MA)]
To establish Department of Energy (DOE) and National Nuclear Security Administration (NNSA) requirements and responsibilities governing official foreign travel by Federal and contractor employees. Cancels DOE O 551.1. Canceled by DOE O 551.1B.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
To establish Department of Energy (DOE) and National Nuclear Security Administration (NNSA) requirements and responsibilities governing official foreign travel by Federal and contractor employees. Cancels DOE O 551.1A. Canceled by DOE O 551.1C.
Directives, Delegations, and Other Requirements [Office of Management (MA)]
Establishes Department of Energy (DOE) requirements and responsibilities governing official foreign travel by Federal and contract employees. Cancels DOE O 1500.3. Canceled by DOE O 551.1A.
Omega World Travel Awarded JLab Contract for Travel Services | Jefferson
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Lab Omega World Travel Awarded JLab Contract for Travel Services Omega World Travel Awarded JLab Contract for Travel Services Effective today, ALL travel to go through Omega World Travel. The Concur On-line Travel System is up and running. You can access it now. Questions / Concerns Omega representatives will be holding informational / training sessions August 1st 3:00pm - 4:00pm and August 2nd 2:00pm - 3:00pm in the Cebaf Center Auditorium. All staff are encouraged to attend. Topics will
Energy Information Administration (EIA) (indexed site)
MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels
Transferring 2001 National Household Travel Survey
Hu, Patricia S; Reuscher, Tim; Schmoyer, Richard L; Chin, Shih-Miao
Policy makers rely on transportation statistics, including data on personal travel behavior, to formulate strategic transportation policies, and to improve the safety and efficiency of the U.S. transportation system. Data on personal travel trends are needed to examine the reliability, efficiency, capacity, and flexibility of the Nation's transportation system to meet current demands and to accommodate future demand. These data are also needed to assess the feasibility and efficiency of alternative congestion-mitigating technologies (e.g., high-speed rail, magnetically levitated trains, and intelligent vehicle and highway systems); to evaluate the merits of alternative transportation investment programs; and to assess the energy-use and air-quality impacts of various policies. To address these data needs, the U.S. Department of Transportation (USDOT) initiated an effort in 1969 to collect detailed data on personal travel. The 1969 survey was the first Nationwide Personal Transportation Survey (NPTS). The survey was conducted again in 1977, 1983, 1990, 1995, and 2001. Data on daily travel were collected in 1969, 1977, 1983, 1990 and 1995. In 2001, the survey was renamed the National Household Travel Survey (NHTS) and it collected both daily and long-distance trips. The 2001 survey was sponsored by three USDOT agencies: Federal Highway Administration (FHWA), Bureau of Transportation Statistics (BTS), and National Highway Traffic Safety Administration (NHTSA). The primary objective of the survey was to collect trip-based data on the nature and characteristics of personal travel so that the relationships between the characteristics of personal travel and the demographics of the traveler can be established. Commercial and institutional travel were not part of the survey. Due to the survey's design, data in the NHTS survey series were not recommended for estimating travel statistics for categories smaller than the combination of Census division (e.g., New England, Middle
Reporting Unofficial Foreign Travel
Directives, Delegations, and Other Requirements [Office of Management (MA)]
Establishes requirements for the reporting of unofficial travel to foreign countries by DOE and DOE contractor employees that hold an access authorization (personnel security clearances). DOE N 251.40, dated 5/3/01, extended this directive until 12/31/01.
Travel Resources | The Ames Laboratory
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Resources Airline Baggage Policies Amtrak Argonne Guest House Association of Corporate Travel Executives Database of hotels that meet fire safety code GSA Per Diem Rates Iowa Road Work ISU - Office Procedure Guide - Travel Policies Map Quest Atlas National Business Travel Association Weather Channel Web Flyer
2001 New York State NHTS: Travel Patterns of Special Populations
Hu, Patricia S; Reuscher, Tim
Policymakers rely on transportation statistics, including data on personal travel behavior, to formulate strategic transportation policies, and to improve the safety and efficiency of the U.S. transportation system. Data on personal travel trends are needed to examine the reliability, efficiency, capacity, and flexibility of the Nation's transportation system to meet current demands and accommodate future demands; to assess the feasibility and efficiency of alternative congestion-alleviating technologies (e.g., high-speed rail, magnetically levitated trains, intelligent vehicle and highway systems); to evaluate the merits of alternative transportation investment programs; and to assess the energy-use and air-quality impacts of various policies. To address these data needs, the U.S. Department of Transportation (USDOT) initiated an effort in 1969 to collect detailed data on personal travel. The 1969 survey was the first Nationwide Personal Transportation Survey (NPTS). The survey was conducted again in 1977, 1983, 1990, 1995, and 2001. Data on daily travel were collected in 1969, 1977, 1983, 1990 and 1995. Longer-distance travel was collected in 1977 and 1995. The 2001 National Household Travel Survey (NHTS) collected both daily and longer-distance trips in one survey. The 2001 survey was sponsored by three USDOT agencies: Federal Highway Administration (FHWA), Bureau of Transportation Statistics (BTS), and National Highway Traffic Safety Administration (NHTSA). The primary objective of the survey was to collect trip-based data on the nature and characteristics of personal travel so that the relationships between the characteristics of personal travel and the demographics of the traveler can be established. Commercial and institutional travel was not part of the survey. New York State participated in the 2001 NHTS by procuring additional 12,000 sample households. These additional sample households allowed New York State to address transportation planning issues
... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...
Interviewee Travel Regulations Scope
U.S. Department of Energy (DOE) - all webpages (Extended Search)
rucks that travel in the western United States will soon be able to operate clean-burning alternative fuel vehicles (AFVs) along the Interstate Clean Transpor- tation Corridor (ICTC). The ICTC project is the first effort to develop clean transportation corridors to connect Los Angeles, San Bernar- dino, the San Joaquin Valley, Sacra- mento/San Francisco, Salt Lake City, Reno, and Las Vegas along routes 1-15, 1-80, and 1-5/CA-99. The ICTC team, headed by California- based Gladstein and
Foreign Travel | The Ames Laboratory
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Guidance Foreign Trip Report Template Trip Report Example 1 Trip Report Example 2 Insurance: Travelers are eligible for the Cultural Insurance Services International (CISI)...
Southern Asia future plans feature long-distance lines
Not Available
This paper reports that although pipe line mileage working, planned and under study has dipped slightly from 47,346 km (29,420 mi) to 44,853 km (27,871 mi), Southern Asia continues to hold a strong position for future projects with some of the most interesting programs in the international market. Two dramatic, long-distance natural gas transmission, gathering and lateral networks continue to hold the future pipe line construction spotlight in Southern Asia. The Association of South East Asian Nations (ASEAN) continues to study a 7,830 km (4,865 mi) gas transmission system. With an estimated cost of $10 billion, the system includes some 6,276 km (3,900 mi) of transmission lines, with 1,094 km (680 mi) offshore. Group members include Brunei, Indonesia, Malaysia, the Philippines, Singapore and Thailand. The second project, the Trans-Asian Pipeline System, involves 3,380 km (2,100 mi) of transmission lines from the Iran's Bandar Abbas gas field across Pakistan to a terminal at Calcutta, India.
Office of Scientific and Technical Information (OSTI)
Real-time sub-
Fact #612: March 1, 2010 The Distance of Trips to Work
The recently released Nationwide Household Travel Survey shows that nearly 60% of work trips are 10 miles or less in distance. Only 9% of work trips are over 30 miles. The average work trip...
Mi GmbH | Open Energy Information
OpenEI (Open Energy Information) [EERE & EIA]
Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...
ORISE: Travelers' Health Campaign | How ORISE is Making a Difference
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travelers' Health Campaign Travelers' Health Campaign takes critical messages worldwide Travelers' Health Campaign poster Click image to enlarge Traveling can be a dangerous...
Chapter 3. Vehicle-Miles Traveled
Energy Information Administration (EIA) (indexed site)
3. Vehicle-Miles Traveled Chapter 3. Vehicle-Miles Traveled Vehicle-miles traveled--the number of miles that residential vehicles are driven--is probably the most important...
Online Travel Reservations through "Concur Travel" | The Ames...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
T&T, it allows Laboratory travelers to direct bill airfare and rental car arrangements. ... One-way car rentals to and from the airport. Those must be booked separately through ...
New York Household Travel Patterns: A Comparison Analysis
Hu, Patricia S; Reuscher, Tim
In 1969, the U. S. Department of Transportation began collecting detailed data on personal travel to address various transportation planning issues. These issues range from assessing transportation investment programs to developing new technologies to alleviate congestion. This 1969 survey was the birth of the Nationwide Personal Transportation Survey (NPTS). The survey was conducted again in 1977, 1983, 1990 and 1995. Longer-distance travel was collected in 1977 and 1995. In 2001, the survey was renamed to the National Household Travel Survey (NHTS) and collected both daily and longer-distance trips in one survey. In addition to the number of sample households that the national NPTS/NHTS survey allotted to New York State (NYS), the state procured an additional sample of households in both the 1995 and 2001 surveys. In the 1995 survey, NYS procured an addition sample of more than 9,000 households, increasing the final NY NPTS sample size to a total of 11,004 households. Again in 2001, NYS procured 12,000 additional sample households, increasing the final New York NHTS sample size to a total of 13,423 households with usable data. These additional sample households allowed NYS to address transportation planning issues pertinent to geographic areas significantly smaller than for what the national NPTS and NHTS data are intended. Specifically, these larger sample sizes enable detailed analysis of twelve individual Metropolitan Planning Organizations (MPOs). Furthermore, they allowed NYS to address trends in travel behavior over time. In this report, travel data for the entire NYS were compared to those of the rest of the country with respect to personal travel behavior and key travel determinants. The influence of New York City (NYC) data on the comparisons of the state of New York to the rest of the country was also examined. Moreover, the analysis examined the relationship between population density and travel patterns, and the similarities and differences among New
Microsoft Word - Travel Checklist.doc
U.S. Department of Energy (DOE) - all webpages (Extended Search)
kinds of tickets are and are not reimbursable are, in conjunction with the ongoing globalization of airline and other travel consortiums, complex enough that whether a travel...
EPA Webinar - Travel Efficiency Assessment Method: Evaluating...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
EPA Webinar - Travel Efficiency Assessment Method: Evaluating the Potential to Reduce Emissions in Three Case Study Areas EPA Webinar - Travel Efficiency Assessment Method: ...
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) This schedule covers records documenting the ...
Stable operating regime for traveling wave devices
Carlsten, Bruce E.
Autophase stability is provided for a traveling wave device (TWD) electron beam for amplifying an RF electromagnetic wave in walls defining a waveguide for said electromagnetic wave. An off-axis electron beam is generated at a selected energy and has an energy noise inherently arising from electron gun. The off-axis electron beam is introduced into the waveguide. The off-axis electron beam is introduced into the waveguide at a second radius. The waveguide structure is designed to obtain a selected detuning of the electron beam. The off-axis electron beam has a velocity and the second radius to place the electron beam at a selected distance from the walls defining the waveguide, wherein changes in a density of the electron beam due to the RF electromagnetic wave are independent of the energy of the electron beam to provide a concomitant stable operating regime relative to the energy noise.
Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.
Sequentially pulsed traveling wave accelerator
Caporaso, George J.; Nelson, Scott D.; Poole, Brian R.
A sequentially pulsed traveling wave compact accelerator having two or more pulse forming lines each with a switch for producing a short acceleration pulse along a short length of a beam tube, and a trigger mechanism for sequentially triggering the switches so that a traveling axial electric field is produced along the beam tube in synchronism with an axially traversing pulsed beam of charged particles to serially impart energy to the particle beam.
Quantifying the Effect of Fast Charger Deployments on Electric Vehicle Utility and Travel Patterns via Advanced Simulation: Preprint
Wood, E.; Neubauer, J.; Burton, E.
The disparate characteristics between conventional (CVs) and battery electric vehicles (BEVs) in terms of driving range, refill/recharge time, and availability of refuel/recharge infrastructure inherently limit the relative utility of BEVs when benchmarked against traditional driver travel patterns. However, given a high penetration of high-power public charging combined with driver tolerance for rerouting travel to facilitate charging on long-distance trips, the difference in utility between CVs and BEVs could be marginalized. We quantify the relationships between BEV utility, the deployment of fast chargers, and driver tolerance for rerouting travel and extending travel durations by simulating BEVs operated over real-world travel patterns using the National Renewable Energy Laboratory's Battery Lifetime Analysis and Simulation Tool for Vehicles (BLAST-V). With support from the U.S. Department of Energy's Vehicle Technologies Office, BLAST-V has been developed to include algorithms for estimating the available range of BEVs prior to the start of trips, for rerouting baseline travel to utilize public charging infrastructure when necessary, and for making driver travel decisions for those trips in the presence of available public charging infrastructure, all while conducting advanced vehicle simulations that account for battery electrical, thermal, and degradation response. Results from BLAST-V simulations on vehicle utility, frequency of inserted stops, duration of charging events, and additional time and distance necessary for rerouting travel are presented to illustrate how BEV utility and travel patterns can be affected by various fast charge deployments.
DOE - Office of Legacy Management -- Detrex Corp - MI 10
Office of Legacy Management (LM)
Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...
Enabling time travel for the scholarly web
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Enabling time travel for the scholarly web Enabling time travel for the scholarly web An international team of information scientists has begun a study to investigate how web links ...
DOE - Office of Legacy Management -- Adrian - MI 01
Office of Legacy Management (LM)
Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):
DOE - Office of Legacy Management -- Oliver Corp - MI 11
Office of Legacy Management (LM)
OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...
Analysis of plug-in hybrid electric vehicles' utility factors using GPS-based longitudinal travel data
Wu, Xing; Aviquzzaman, Md.; Lin, Zhenhong
The benefit of using a PHEV comes from its ability to substitute gasoline with electricity in operation. Defined as the proportion of distance traveled in the electric mode, the utility factor (UF) depends mostly on the battery capacity, but also on many other factors, such as travel pattern and recharging pattern. Conventionally, the UFs are calculated based on the daily vehicle miles traveled (DVMT) by assuming motorists leave home in the morning with a full battery, and no charge occurs before returning home in the evening. Such an assumption, however, ignores the impact of the heterogeneity in both travel andmore » charging behavior, such as going back home more than once in a day, the impact of available charging time, and the price of gasoline. In addition, the conventional UFs are based on the National Household Travel Survey (NHTS) data, which are one-day travel data of each sample vehicle. A motorist's daily distance variation is ignored. This paper employs the GPS-based longitudinal travel data (covering 3-18 months) collected from 403 vehicles in the Seattle metropolitan area to investigate how such travel and charging behavior affects UFs. To do this, for each vehicle, we organized trips to a series of home and work related tours. The UFs based on the DVMT are found close to those based on home-to-home tours. However, it is seen that the workplace charge opportunities significantly increase UFs if the CD range is no more than 40 miles.« less
Analysis of plug-in hybrid electric vehicles' utility factors using GPS-based longitudinal travel data
Wu, Xing; Aviquzzaman, Md.; Lin, Zhenhong
The benefit of using a PHEV comes from its ability to substitute gasoline with electricity in operation. Defined as the proportion of distance traveled in the electric mode, the utility factor (UF) depends mostly on the battery capacity, but also on many other factors, such as travel pattern and recharging pattern. Conventionally, the UFs are calculated based on the daily vehicle miles traveled (DVMT) by assuming motorists leave home in the morning with a full battery, and no charge occurs before returning home in the evening. Such an assumption, however, ignores the impact of the heterogeneity in both travel and charging behavior, such as going back home more than once in a day, the impact of available charging time, and the price of gasoline. In addition, the conventional UFs are based on the National Household Travel Survey (NHTS) data, which are one-day travel data of each sample vehicle. A motorist's daily distance variation is ignored. This paper employs the GPS-based longitudinal travel data (covering 3-18 months) collected from 403 vehicles in the Seattle metropolitan area to investigate how such travel and charging behavior affects UFs. To do this, for each vehicle, we organized trips to a series of home and work related tours. The UFs based on the DVMT are found close to those based on home-to-home tours. However, it is seen that the workplace charge opportunities significantly increase UFs if the CD range is no more than 40 miles.
SRI2007 Conference - Travel Tips
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel Tips Getting to the Hilton Baton Rouge Capitol Center: From the Baton Rouge Metropolitan Airport (BTR) From the New Orleans International Airport (MSY) Shuttles to and from the Baton Rouge Metropolitan Airport are offered by the Hilton Baton Rouge Capitol Center upon prior arrangements with the hotel. Capitol Park Trolley (pdf) offers free service to downtown restaurants and attractions Monday through Friday, 10:30 am - 2:30 pm. Local rental car companies, click here. Parking: The Hilton
How many electric miles do Nissan Leafs and Chevrolet Volts in The EV Project travel?
John Smart
This paper presents travel statistics and metrics describing the driving behavior of Nissan Leaf and Chevrolet Volt drivers in the EV Project. It specifically quantifies the distance each group of vehicles drives each month. This paper will be published to INL's external website and will be accessible by the general public.
Secure distance ranging by electronic means
Gritton, Dale G.
A system for secure distance ranging between a reader 11 and a tag 12 wherein the distance between the two is determined by the time it takes to propagate a signal from the reader to the tag and for a responsive signal to return, and in which such time is random and unpredictable, except to the reader, even though the distance between the reader and tag remains the same. A random number (19) is sent from the reader and encrypted (26) by the tag into a number having 16 segments of 4 bits each (28). A first tag signal (31) is sent after such encryption. In response, a random width start pulse (13) is generated by the reader. When received in the tag, the width of the start pulse is measured (41) in the tag and a segment of the encrypted number is selected (42) in accordance with such width. A second tag pulse is generated at a time T after the start pulse arrives at the tag, the time T being dependent on the length of a variable time delay t.sub.v which is determined by the value of the bits in the selected segment of the encrypted number. At the reader, the total time from the beginning of the start pulse to the receipt of the second tag signal is measured (36, 37). The value of t.sub.v (21, 22, 23, 34) is known at the reader and the time T is subtracted (46) from the total time to find the actual propagation t.sub.p for signals to travel between the reader 11 and tag 12. The propagation time is then converted into distance (46).
Combined distance-of-flight and time-of-flight mass spectrometer
Enke, Christie G; Ray, Steven J; Graham, Alexander W; Hieftje, Gary M; Barinaga, Charles J; Koppenaal, David W
A combined distance-of-flight mass spectrometry (DOFMS) and time-of-flight mass spectrometry (TOFMS) instrument includes an ion source configured to produce ions having varying mass-to-charge ratios, a first detector configured to determine when each of the ions travels a predetermined distance, a second detector configured to determine how far each of the ions travels in a predetermined time, and a detector extraction region operable to direct portions of the ions either to the first detector or to the second detector.
Stopping distance for high energy jets in weakly coupled quark-gluon plasmas
Arnold, Peter; Cantrell, Sean; Xiao Wei
We derive a simple formula for the stopping distance for a high-energy quark traveling through a weakly coupled quark-gluon plasma. The result is given to next-to-leading order in an expansion in inverse logarithms ln(E/T), where T is the temperature of the plasma. We also define a stopping distance for gluons and give a leading-log result. Discussion of stopping distance has a theoretical advantage over discussion of energy loss rates in that stopping distances can be generalized to the case of strong coupling, where one may not speak of individual partons.
Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al
Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.
Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.
Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Stop & Go Trips ( >5 stops/mile) DC electrical energy consumption (DC Wh/mi) 486 Number of trips 8,449 Distance traveled (mi) 2,381 Percent of total distance traveled (%) 60% Average Trip Distance (mi) 0.3 Average Driving Speed (mph) 5.3 Average Stops per mile 32.3 Percent of Regen Braking Energy Recovery (%) 14% City Trips ( < 5 stops/mile & <37 mph avg) DC electrical energy consumption (DC Wh/mi) 402 Number of trips 694 Distance traveled (mi) 1,450 Percent of total distance
Fermilab | Tevatron | Tevatron Symposium | Travel and Lodging
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel and Lodging Directions to Fermilab Local Accommodations Map of Local Hotels Transportation Visa Information Wifi Access at Fermilab Other Useful Links
Code for Calculating Regional Seismic Travel Time
Energy Science and Technology Software Center
The RSTT software computes predictions of the travel time of seismic energy traveling from a source to a receiver through 2.5D models of the seismic velocity distribution within the Earth. The two primary applications for the RSTT library are tomographic inversion studies and seismic event location calculations. In tomographic inversions studies, a seismologist begins with number of source-receiver travel time observations and an initial starting model of the velocity distribution within the Earth. A forwardmore » travel time calculator, such as the RSTT library, is used to compute predictions of each observed travel time and all of the residuals (observed minus predicted travel time) are calculated. The Earth model is then modified in some systematic way with the goal of minimizing the residuals. The Earth model obtained in this way is assumed to be a better model than the starting model if it has lower residuals. The other major application for the RSTT library is seismic event location. Given an Earth model, an initial estimate of the location of a seismic event, and some number of observations of seismic travel time thought to have originated from that event, location codes systematically modify the estimate of the location of the event with the goal of minimizing the difference between the observed and predicted travel times. The second application, seismic event location, is routinely implemented by the military as part of its effort to monitor the Earth for nuclear tests conducted by foreign countries.« less
NEUP Foreign Travel Request Form | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Foreign Travel Request Form NEUP Foreign Travel Request Form NEUP Foreign Travel Request Form NEUP Foreign Travel Form 07_31_12.docx (62.57 KB) More Documents & Publications DOE F 551.1 NEUP Student Travel Request Form HQ FNVA Questionnaire
NEUP Student Travel Request Form | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Student Travel Request Form NEUP Student Travel Request Form NEUP Fellowship Travel Request Form Student Travel Request Form.pdf (31.13 KB) More Documents & Publications Investing in the next generation: The Office of Nuclear Energy Issues Requests for Scholarship and Fellowship Applications. NEUP Foreign Travel Request Form NEUP Fellowship Information Packet
Positioner with long travel in two dimensions
Trumper, David L.; Williams, Mark E.
A precision positioning system is provided which provides long travel in two of the linear dimensions, while using non-contact bearings for both a first subassembly which provides long travel in one of the linear dimension and a second subassembly which provides long travel in the second linear dimension. The first or upper subassembly is preferably a magnetic subassembly which, in addition to providing long travel, also compensates or positions in three rotary dimensions and in the third linear dimension. The second subassembly is preferably either an air bearing or magnetic subassembly and is normally used only to provide long travel. Angled surfaces may be provided for magnetic bearings and capacitive or other gap sensing probes may be mounted to the stage and ground flush with the bearing actuators to provide more precise gap measurements.
Traveling-wave device with mass flux suppression (Patent) | DOEPatents
Office of Scientific and Technical Information (OSTI)
Traveling-wave device with mass flux suppression Title: Traveling-wave device with mass flux suppression A traveling-wave device is provided with the conventional moving pistons ...
Which Road to Travel? | Y-12 National Security Complex
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Which Road to Travel? Which Road to Travel? Posted: July 16, 2013 - 6:06pm There's no question which road (crosswalk) to travel when you park in the North Portal parking lot. ...
Better World Club Travel Cool | Open Energy Information
OpenEI (Open Energy Information) [EERE & EIA]
World Club Travel Cool Jump to: navigation, search Name: Better World Club Travel Cool Place: Portland, Oregon Zip: 97209 Product: Travel Cool is the eNewsletter of the Better...
Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...
Energy Information Administration (EIA) (indexed site)
Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...
DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...
Office of Legacy Management (LM)
Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...
Supplemental Guidance Regarding Compensatory Time Off for Travel |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy Supplemental Guidance Regarding Compensatory Time Off for Travel Supplemental Guidance Regarding Compensatory Time Off for Travel Questions and answers on issues that supplement the final regulations on compensatory time for travel issued by the Office of Personnel Management. In addition, a sample worksheet is attached to assist travelers in determining and documenting their travel time that may be credited for compensatory time for travel. This information will be
miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor
Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.
Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.
Venue and Travel | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Venue and Travel Venue and Travel Venue and Travel Hilton Anaheim 777 W Convention Way Anaheim, California, 92802 USA TEL: 1-714-750-4321 FAX: 1-714-740-4460 Reserving Your Room For your convenience, a limited room block has been set up at the group rate of $133 per night (plus applicable taxes). Space is limited and will sell out fast. Reservations can be made via the call center 1-877-776-4932 using the group code: SGE or you can book online: SunShot Grand Challenge Summit Room Block.
ORISE: CDC Travelers' Health Mobile App, Designed by ORISE, Gains...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
choices while traveling internationally and tasked ORISE with designing iPhone and Android versions. "Nothing is more important to us than the health and safety of travelers,...
"Nodal Gap" induced by the incommensurate diagonal spin density modulation in underdoped high- superconductors
Zhou, Tao; Gao, Yi; Zhu, Jian -Xin
Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the -wave nodal lines (nodal gap) contrasts the common understanding of the -wave pairing symmetry, which challenges the present theories for the high-superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-superconductors.
Measurement of differential production cross sections and forward-backward ratios in collisions with the ATLAS detector
Aad, G.; Abbott, B.; Abdallah, J.; Abdel Khalek, S.; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; AbouZeid, O. S.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Adelman, J.; Adomeit, S.; Adye, T.; Agatonovic-Jovin, T.; Aguilar-Saavedra, J. A.; Agustoni, M.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akerstedt, H.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albrand, S.; Alconada Verzini, M. J.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Alimonti, G.; Alio, L.; Alison, J.; Allbrooke, B. M. M.; Allison, L. J.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Altheimer, A.; Alvarez Gonzalez, B.; Alviggi, M. G.; Amako, K.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amram, N.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Anduaga, X. S.; Angelidakis, S.; Angelozzi, I.; Anger, P.; Angerami, A.; Anghinolfi, F.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Arce, A. T. H.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnal, V.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Artoni, G.; Asai, S.; Asbah, N.; Ashkenazi, A.; Åsman, B.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Auerbach, B.; Augsten, K.; Aurousseau, M.; Avolio, G.; Axen, B.; Azuelos, G.; Baak, M. A.; Baas, A. E.; Bacci, C.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Bagiacchi, P.; Bagnaia, P.; Bai, Y.; Bain, T.; Baines, J. T.; Baker, O. K.; Balek, P.; Balestri, T.; Balli, F.; Banas, E.; Banerjee, Sw.; Bannoura, A. A. E.; Bansil, H. S.; Barak, L.; Barberio, E. 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B.; Simak, V.; Simard, O.; Simic, Lj.; Simion, S.; Simioni, E.; Simmons, B.; Simon, D.; Simoniello, R.; Sinervo, P.; Sinev, N. B.; Siragusa, G.; Sircar, A.; Sisakyan, A. N.; Sivoklokov, S. Yu.; Sjölin, J.; Sjursen, T. B.; Skottowe, H. P.; Skubic, P.; Slater, M.; Slavicek, T.; Slawinska, M.; Sliwa, K.; Smakhtin, V.; Smart, B. H.; Smestad, L.; Smirnov, S. Yu.; Smirnov, Y.; Smirnova, L. N.; Smirnova, O.; Smith, K. M.; Smith, M. N. K.; Smizanska, M.; Smolek, K.; Snesarev, A. A.; Snidero, G.; Snyder, S.; Sobie, R.; Socher, F.; Soffer, A.; Soh, D. A.; Solans, C. A.; Solar, M.; Solc, J.; Soldatov, E. Yu.; Soldevila, U.; Solodkov, A. A.; Soloshenko, A.; Solovyanov, O. V.; Solovyev, V.; Sommer, P.; Song, H. Y.; Soni, N.; Sood, A.; Sopczak, A.; Sopko, B.; Sopko, V.; Sorin, V.; Sosa, D.; Sosebee, M.; Soualah, R.; Soueid, P.; Soukharev, A. M.; South, D.; Spagnolo, S.; Spanò, F.; Spearman, W. R.; Spettel, F.; Spighi, R.; Spigo, G.; Spiller, L. A.; Spousta, M.; Spreitzer, T.; St. Denis, R. D.; Staerz, S.; Stahlman, J.; Stamen, R.; Stamm, S.; Stanecka, E.; Stanescu, C.; Stanescu-Bellu, M.; Stanitzki, M. M.; Stapnes, S.; Starchenko, E. A.; Stark, J.; Staroba, P.; Starovoitov, P.; Staszewski, R.; Stavina, P.; Steinberg, P.; Stelzer, B.; Stelzer, H. J.; Stelzer-Chilton, O.; Stenzel, H.; Stern, S.; Stewart, G. A.; Stillings, J. A.; Stockton, M. C.; Stoebe, M.; Stoicea, G.; Stolte, P.; Stonjek, S.; Stradling, A. R.; Straessner, A.; Stramaglia, M. E.; Strandberg, J.; Strandberg, S.; Strandlie, A.; Strauss, E.; Strauss, M.; Strizenec, P.; Ströhmer, R.; Strom, D. M.; Stroynowski, R.; Strubig, A.; Stucci, S. A.; Stugu, B.; Styles, N. A.; Su, D.; Su, J.; Subramaniam, R.; Succurro, A.; Sugaya, Y.; Suhr, C.; Suk, M.; Sulin, V. V.; Sultansoy, S.; Sumida, T.; Sun, S.; Sun, X.; Sundermann, J. E.; Suruliz, K.; Susinno, G.; Sutton, M. R.; Suzuki, Y.; Svatos, M.; Swedish, S.; Swiatlowski, M.; Sykora, I.; Sykora, T.; Ta, D.; Taccini, C.; Tackmann, K.; Taenzer, J.; Taffard, A.; Tafirout, R.; Taiblum, N.; Takai, H.; Takashima, R.; Takeda, H.; Takeshita, T.; Takubo, Y.; Talby, M.; Talyshev, A. A.; Tam, J. Y. C.; Tan, K. G.; Tanaka, J.; Tanaka, R.; Tanaka, S.; Tanaka, S.; Tanasijczuk, A. J.; Tannenwald, B. B.; Tannoury, N.; Tapprogge, S.; Tarem, S.; Tarrade, F.; Tartarelli, G. F.; Tas, P.; Tasevsky, M.; Tashiro, T.; Tassi, E.; Tavares Delgado, A.; Tayalati, Y.; Taylor, F. E.; Taylor, G. N.; Taylor, W.; Teischinger, F. A.; Teixeira Dias Castanheira, M.; Teixeira-Dias, P.; Temming, K. K.; Ten Kate, H.; Teng, P. K.; Teoh, J. J.; Tepel, F.; Terada, S.; Terashi, K.; Terron, J.; Terzo, S.; Testa, M.; Teuscher, R. J.; Therhaag, J.; Theveneaux-Pelzer, T.; Thomas, J. P.; Thomas-Wilsker, J.; Thompson, E. N.; Thompson, P. D.; Thompson, R. J.; Thompson, A. S.; Thomsen, L. A.; Thomson, E.; Thomson, M.; Thong, W. M.; Thun, R. P.; Tian, F.; Tibbetts, M. J.; Ticse Torres, R. E.; Tikhomirov, V. O.; Tikhonov, Yu. A.; Timoshenko, S.; Tiouchichine, E.; Tipton, P.; Tisserant, S.; Todorov, T.; Todorova-Nova, S.; Tojo, J.; Tokár, S.; Tokushuku, K.; Tollefson, K.; Tolley, E.; Tomlinson, L.; Tomoto, M.; Tompkins, L.; Toms, K.; Topilin, N. D.; Torrence, E.; Torres, H.; Torró Pastor, E.; Toth, J.; Touchard, F.; Tovey, D. R.; Tran, H. L.; Trefzger, T.; Tremblet, L.; Tricoli, A.; Trigger, I. M.; Trincaz-Duvoid, S.; Tripiana, M. F.; Trischuk, W.; Trocmé, B.; Troncon, C.; Trottier-McDonald, M.; Trovatelli, M.; True, P.; Trzebinski, M.; Trzupek, A.; Tsarouchas, C.; Tseng, J. C-L.; Tsiareshka, P. V.; Tsionou, D.; Tsipolitis, G.; Tsirintanis, N.; Tsiskaridze, S.; Tsiskaridze, V.; Tskhadadze, E. G.; Tsukerman, I. I.; Tsulaia, V.; Tsuno, S.; Tsybychev, D.; Tudorache, A.; Tudorache, V.; Tuna, A. N.; Tupputi, S. A.; Turchikhin, S.; Turecek, D.; Turra, R.; Turvey, A. J.; Tuts, P. M.; Tykhonov, A.; Tylmad, M.; Tyndel, M.; Ueda, I.; Ueno, R.; Ughetto, M.; Ugland, M.; Uhlenbrock, M.; Ukegawa, F.; Unal, G.; Undrus, A.; Unel, G.; Ungaro, F. C.; Unno, Y.; Unverdorben, C.; Urban, J.; Urquijo, P.; Urrejola, P.; Usai, G.; Usanova, A.; Vacavant, L.; Vacek, V.; Vachon, B.; Valencic, N.; Valentinetti, S.; Valero, A.; Valery, L.; Valkar, S.; Valladolid Gallego, E.; Vallecorsa, S.; Valls Ferrer, J. A.; Van Den Wollenberg, W.; Van Der Deijl, P. C.; van der Geer, R.; van der Graaf, H.; Van Der Leeuw, R.; van Eldik, N.; van Gemmeren, P.; Van Nieuwkoop, J.; van Vulpen, I.; van Woerden, M. C.; Vanadia, M.; Vandelli, W.; Vanguri, R.; Vaniachine, A.; Vannucci, F.; Vardanyan, G.; Vari, R.; Varnes, E. W.; Varol, T.; Varouchas, D.; Vartapetian, A.; Varvell, K. E.; Vazeille, F.; Vazquez Schroeder, T.; Veatch, J.; Veloso, F.; Velz, T.; Veneziano, S.; Ventura, A.; Ventura, D.; Venturi, M.; Venturi, N.; Venturini, A.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, J. C.; Vest, A.; Vetterli, M. C.; Viazlo, O.; Vichou, I.; Vickey, T.; Vickey Boeriu, O. E.; Viehhauser, G. H. A.; Viel, S.; Vigne, R.; Villa, M.; Villaplana Perez, M.; Vilucchi, E.; Vincter, M. G.; Vinogradov, V. B.; Virzi, J.; Vivarelli, I.; Vives Vaque, F.; Vlachos, S.; Vladoiu, D.; Vlasak, M.; Vogel, M.; Vokac, P.; Volpi, G.; Volpi, M.; von der Schmitt, H.; von Radziewski, H.; von Toerne, E.; Vorobel, V.; Vorobev, K.; Vos, M.; Voss, R.; Vossebeld, J. H.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vuillermet, R.; Vukotic, I.; Vykydal, Z.; Wagner, P.; Wagner, W.; Wahlberg, H.; Wahrmund, S.; Wakabayashi, J.; Walder, J.; Walker, R.; Walkowiak, W.; Wang, C.; Wang, F.; Wang, H.; Wang, H.; Wang, J.; Wang, J.; Wang, K.; Wang, R.; Wang, S. M.; Wang, T.; Wang, X.; Wanotayaroj, C.; Warburton, A.; Ward, C. P.; Wardrope, D. R.; Warsinsky, M.; Washbrook, A.; Wasicki, C.; Watkins, P. M.; Watson, A. T.; Watson, I. J.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, B. M.; Webb, S.; Weber, M. S.; Weber, S. W.; Webster, J. S.; Weidberg, A. R.; Weinert, B.; Weingarten, J.; Weiser, C.; Weits, H.; Wells, P. S.; Wenaus, T.; Wendland, D.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Wessels, M.; Wetter, J.; Whalen, K.; Wharton, A. M.; White, A.; White, M. J.; White, R.; White, S.; Whiteson, D.; Wicke, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik-Fuchs, L. A. M.; Wildauer, A.; Wilkens, H. G.; Williams, H. H.; Williams, S.; Willis, C.; Willocq, S.; Wilson, A.; Wilson, J. A.; Wingerter-Seez, I.; Winklmeier, F.; Winter, B. T.; Wittgen, M.; Wittkowski, J.; Wollstadt, S. J.; Wolter, M. W.; Wolters, H.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wozniak, K. W.; Wu, M.; Wu, S. L.; Wu, X.; Wu, Y.; Wyatt, T. R.; Wynne, B. M.; Xella, S.; Xu, D.; Xu, L.; Yabsley, B.; Yacoob, S.; Yakabe, R.; Yamada, M.; Yamaguchi, Y.; Yamamoto, A.; Yamamoto, S.; Yamanaka, T.; Yamauchi, K.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, H.; Yang, Y.; Yanush, S.; Yao, L.; Yao, W-M.; Yasu, Y.; Yatsenko, E.; Yau Wong, K. H.; Ye, J.; Ye, S.; Yeletskikh, I.; Yen, A. L.; Yildirim, E.; Yorita, K.; Yoshida, R.; Yoshihara, K.; Young, C.; Young, C. J. S.; Youssef, S.; Yu, D. R.; Yu, J.; Yu, J. M.; Yu, J.; Yuan, L.; Yurkewicz, A.; Yusuff, I.; Zabinski, B.; Zaidan, R.; Zaitsev, A. M.; Zaman, A.; Zambito, S.; Zanello, L.; Zanzi, D.; Zeitnitz, C.; Zeman, M.; Zemla, A.; Zengel, K.; Zenin, O.; Ženiš, T.; Zerwas, D.; Zhang, D.; Zhang, F.; Zhang, J.; Zhang, L.; Zhang, R.; Zhang, X.; Zhang, Z.; Zhao, X.; Zhao, Y.; Zhao, Z.; Zhemchugov, A.; Zhong, J.; Zhou, B.; Zhou, C.; Zhou, L.; Zhou, L.; Zhou, N.; Zhu, C. G.; Zhu, H.; Zhu, J.; Zhu, Y.; Zhuang, X.; Zhukov, K.; Zibell, A.; Zieminska, D.; Zimine, N. I.; Zimmermann, C.; Zimmermann, R.; Zimmermann, S.; Zinonos, Z.; Ziolkowski, M.; Živković, L.; Zobernig, G.; Zoccoli, A.; zur Nedden, M.; Zurzolo, G.; Zwalinski, L.
Measurements of differential cross sections for J/ψ production in p+Pb collisions at √sNN=5.02TeV at the CERN Large Hadron Collider with the ATLAS detector are presented. The data set used corresponds to an integrated luminosity of 28.1 nb-1. The J/ψ mesons are reconstructed in the dimuon decay channel over the transverse momentum range 8
Hotel and Travel Information for the Summit
The Executive Summit on Wind Research and Development is being held in the Cottonwoods Pavillion at the Hyatt Regency Tamaya Resort and Spa. Here registrants can find summit hotel and travel...
Geostatistical evaluation of travel time uncertainties
Devary, J.L.
Data on potentiometric head and hydraulic conductivity, gathered from the Wolfcamp Formation of the Permian System, have exhibited tremendous spatial variability as a result of heterogeneities in the media and the presence of petroleum and natural gas deposits. Geostatistical data analysis and error propagation techniques (kriging and conditional simulation) were applied to determine the effect of potentiometric head uncertainties on radionuclide travel paths and travel times through the Wolfcamp Formation. Blok-average kriging was utilized to remove measurement error from potentiometric head data. The travel time calculations have been enhanced by the use of an inverse technique to determine the relative hydraulic conductivity along travel paths. In this way, the spatial variability of the hydraulic conductivity corresponding to streamline convergence and divergence may be included in the analysis. 22 references, 11 figures, 1 table.
Characterization of function and regulation of miR-24-1 and miR-31
Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An
To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.
Thurston Regional Planning Council Helps Washingtonians Save on Travel Costs
Thurston County provides travel information for lower costs, improved safety, and faster response to challenges.
PIA - Foreign Travel Management System (FTMS) | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Travel Management System (FTMS) PIA - Foreign Travel Management System (FTMS) PIA - Foreign Travel Management System (FTMS) PIA - Foreign Travel Management System (FTMS) (389.71 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM BUSINESS ENCLAVE
Foreign Travel Health & Wellness Information | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Wellness Programs » Foreign Travel Health & Wellness Information Foreign Travel Health & Wellness Information All travelers should take the following precautions, no matter the destination: Wash hands often with soap and water. Because motor vehicle crashes are a leading cause of injury among travelers, walk and drive defensively; avoid travel at night if possible and always use seat belts. Don't eat or drink dairy products unless you know they have been pasteurized. Never eat
Light-Duty Vehicle Energy Demand, Demographics, and Travel Behavior
Gasoline and Diesel Fuel Update
EIA Conference July 15, 2014 | Washington, DC By Trisha Hutchins, Office of Energy Consumption and Efficiency Analysis Light-duty vehicle energy demand, demographics, and travel behavior Examining changes in light-duty vehicle travel trends 2 EIA Conference: Light-duty vehicle energy demand, demographics, and travel behavior July 15, 2014 * Recent data indicate possible structural shift in travel behavior, measured as vehicle miles traveled (VMT) - VMT per licensed driver, vehicles per capita,
Simulations of neutron multiplicity measurements with MCNP-PoliMi.
Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.
The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.
Emerging Trends in US Vehicle Travel Demand
Gasoline and Diesel Fuel Update
Emerging Trends in US Vehicle Travel Demand www.travelbehavior.us 2014 EIA Energy Conference Nancy McGuckin Travel Behavior Analyst * Historic pattern of VMT per capita * Differences in changes since 2007 by State * Private and Commercial VMT in context * Why Millenials? www.travelbehavior.us 8,000 8,500 9,000 9,500 10,000 10,500 VMT/Capita per Year www.travelbehavior.us VMT per capita: an unprecedented change: Source: McGuckin's analysis of Census Population (Jul 1) and HPMS Historic VM-1
Long working distance interference microscope
Sinclair, Michael B.; DeBoer, Maarten P.; Smith, Norman F.
Disclosed is a long working distance interference microscope suitable for three-dimensional imaging and metrology of MEMS devices and test structures on a standard microelectronics probe station. The long working distance of 10-30 mm allows standard probes or probe cards to be used. This enables nanometer-scale 3-D height profiles of MEMS test structures to be acquired across an entire wafer. A well-matched pair of reference/sample objectives is not required, significantly reducing the cost of this microscope, as compared to a Linnik microinterferometer.
Magnetocrystalline anisotropy in and related Mn-based actinide ferromagnets
Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.
We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in . This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.
DOE - Office of Legacy Management -- Star Cutter Corp - MI 15
Office of Legacy Management (LM)
Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...
MINOS Experiment and NuMI Beam Home Page
U.S. Department of Energy (DOE) - all webpages
NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the
Researchers test novel power system for space travel
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Power system for space travel Researchers test novel power system for space travel The ... "The heat pipe and Stirling engine used in this test are meant to represent one module ...
Traveling to Princeton (NEW) - Combustion Energy Frontier Research...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
You may travel to the Princeton University campus by air, car or train. Travel directions ... You must reserve at least one day in advance. By Car Directions to Princeton can be found ...
Distance Probes of Dark Energy
Kim, A. G.; Padmanabhan, N.; Aldering, G.; Allen, S. W.; Baltay, C.; Cahn, R. N.; D' Andrea, C. B.; Dalal, N.; Dawson, K. S.; Denney, K. D.; et al
We present the results from the Distances subgroup of the Cosmic Frontier Community Planning Study (Snowmass 2013). This document summarizes the current state of the field as well as future prospects and challenges. In addition to the established probes using Type Ia supernovae and baryon acoustic oscillations, we also consider prospective methods based on clusters, active galactic nuclei, gravitational wave sirens and strong lensing time delays.
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy 9: TRAVEL AND TRANSPORTATION RECORDS ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS This schedule covers records documenting the movement of goods and persons under Government orders ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS (23.31 KB) More Documents & Publications ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) ADMINISTRATIVE RECORDS SCHEDULE 6: ACCOUNTABLE OFFICERS' ACCOUNTS RECOR
Checklist for Medical Issues When Traveling Overseas | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Benefits » Wellness Programs » Foreign Travel Health & Wellness Information » Checklist for Medical Issues When Traveling Overseas Checklist for Medical Issues When Traveling Overseas Before the Trip A written confirmation from an appropriate manager, i.e., a Travel Authorization or memorandum, that identifies the employee and country(ies) that will be visited should be provided the medical support staff 4-8 weeks prior to the trip or, if less than 4 weeks, as soon as management or the
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
(Revision 2) | Department of Energy 9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) This schedule covers records documenting the movement of goods and persons under Government orders. ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS (Revision 2) (14.5 KB) More Documents & Publications ADMINISTRATIVE RECORDS SCHEDULE 9: TRAVEL AND TRANSPORTATION RECORDS ADMINISTRATIVE RECORDS SCHEDULE
Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells
Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.
BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the
Jefferson Lab Visitor's Center - Travel Accommodations
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel Accommodations While visiting or working at JLab there are many options for living accommodations. These options vary depending upon the expected length of stay, transportation available and money allotted for housing expenses. The following information has been compiled to assist in the search for living accommodations near the lab. For further assistance e-mail User Liaison or call 757-269-6388. On-Site Accommodations SURA Residence Facility Off-Site Accommodations Negotiated Lodging
Hamiltonian Approach to Nonlinear Travelling Whistler Waves
Webb, G.M.; McKenzie, J.F.; Dubinin, E.; Sauer, K.
A Hamiltonian formulation of nonlinear, parallel propagating, travelling whistler waves is discussed. The model is based on the equations of two-fluid electron-proton plasmas. In the cold gas limit, the complete system of equations reduces to two coupled differential equations for the transverse electron speed u and a phase variable {phi} = {phi}p - {phi}e representing the difference in the phases of the transverse complex velocities of the protons and the electrons. Two integrals of the equations are obtained. The Hamiltonian integral H, is used to classify the trajectories in the ({phi}, w) phase plane, where {phi} and w = u2 are the canonical coordinates. Periodic, oscillation solitary wave and compacton solutions are obtained, depending on the value of the Hamiltonian integral H and the Alfven Mach number M of the travelling wave. The individual electron and proton phase variables {phi}e and {phi}p are determined in terms of {phi} and w. An alternative Hamiltonian formulation in which {phi}-tilde = {phi}p + {phi}e is the new independent variable replacing x is used to write the travelling wave solutions parametrically in terms of {phi}-tilde.
Extension arm for mobile travelers suit case
Byington, Gerald A.
The invention is an apparatus for adjusting a luggage handle in relation to a luggage frame utilized to transport luggage by a traveler. The handle is connected to two extendable and retractable slide tube assemblies, the assemblies allow for the telescoping of the luggage handle to multiple positions in relation to a pair of fixed frame tubes connected to a luggage shell with wheels, to accommodate the height and personal stride of traveler. The luggage handle incorporates triggering buttons that allow ambidextrous and single-handed control of the height of the handle and slide tube assembly in relation to the luggage. The handle and slide tube assembly are connected by interior filaments to pulleys and filaments within two concentric light-weight slide tubes, which are inserted respectively into two fixed frame tubes, to allow a multitude of positions for the slide tubes to lock into the fixed frame tubes. The apparatus can be pushed or pulled by the traveler, and the support shell can accommodate multiple pieces of luggage.
Recent developments in guided wave travel time tomography
Zon, Tim van; Volker, Arno
The concept of predictive maintenance using permanent sensors that monitor the integrity of an installation is an interesting addition to the current method of periodic inspections. Guided wave tomography had been developed to create a map of the wall thickness using the travel times of guided waves. It can be used for both monitoring and for inspection of pipe-segments that are difficult to access, for instance at the location of pipe-supports. An important outcome of the tomography is the minimum remaining wall thickness, as this is critical in the scheduling of a replacement of the pipe-segment. In order to improve the sizing accuracy we have improved the tomography scheme. A number of major improvements have been realized allowing to extend the application envelope to pipes with a larger wall thickness and to larger distances between the transducer rings. Simulation results indicate that the sizing accuracy has improved and that is now possible to have a spacing of 8 meter between the source-ring and the receiver-ring. Additionally a reduction of the number of sensors required might be possible as well.
miR-92a family and their target genes in tumorigenesis and metastasis
Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang
The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.
Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...
Energy Information Administration (EIA) (indexed site)
Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...
miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells
Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun
Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.
New Travel Entry Requirements for Canada Now in Effect
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel Entry Requirements for Canada Now in Effect Foreign Nationals previously exempt from visa requirements to enter Canada, are now required to apply for an online Electronic Travel Authorization (eTA) to fly to or transit through Canada. Exceptions who are not required to apply for an eTA include - U.S. citizens, travelers with a valid Canadian visa. Canadian citizens, including dual citizens, and Canadian permanent residents. Lists of countries whose citizens are now required to apply for
NNSA Administrator D'Agostino's 2010 Nonproliferation Travel Blog |
National Nuclear Security Administration (NNSA)
National Nuclear Security Administration | (NNSA) Administrator D'Agostino's 2010 Nonproliferation Travel Blog NNSA Administrator Thomas D'Agostino is traveling to three locations to see the agency's nonproliferation activities. Follow his trip and find out what NNSA is doing around the world to support President Obama's historic nuclear security agenda. NNSA Administrator Thomas D'Agostino is traveling to three locations to see the agency's nonproliferation activities. Follow his trip and
Petroleum Reduction Strategies to Reduce Vehicle Miles Traveled
For reducing greenhouse gas emissions, the table below describes petroleum reduction strategies to reduce vehicle miles traveled, as well as guidance and best practices for each strategy.
Sec. Chu Travels to Houston | Department of Energy
Office of Environmental Management (EM)
Secretary Chu traveled to Houston, Texas, today to meet with executives from various oil ... This strategy is focused on safely and responsibly developing our oil and gas resources ...
Statement by DOE Spokesperson on Secretary Moniz's Travel to...
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
travel to Geneva on Saturday to join Secretary Kerry in continued negotiations with Iran over its nuclear program. Department of Energy officials have consistently been...
Travelers Rest, South Carolina: Energy Resources | Open Energy...
OpenEI (Open Energy Information) [EERE & EIA]
Travelers Rest, South Carolina: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 34.9676167, -82.4434548 Show Map Loading map......
Secretary Bodman Travels to Saudi Arabia to Discuss Global Energy...
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
business leaders in Jordan. He will also travel to the United Arab Emirates, Qatar, and Egypt, to continue dialogues with global leaders, enhance the United States' relationship...
DOE Honors WIPP Representative for Cutting Travel Costs, Greenhouse...
Office of Environmental Management (EM)
document reviews with regulators instead of meeting in person and reduced rental car usage by standardizing travel arrangements so that only one rental car is necessary per...
miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression
Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao
Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.
Optical distance measurement device and method thereof
Bowers, Mark W.
A system and method of efficiently obtaining distance measurements of a target. A modulated optical beam may be used to determine the distance to the target. A first beam splitter may be used to split the optical beam and a second beam splitter may be used to recombine a reference beam with a return ranging beam. An optical mixing detector may be used in a receiver to efficiently detect distance measurement information.
MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications
Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang
MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.
National Wind Distance Learning Collaborative
Dr. James B. Beddow
Executive Summary The energy development assumptions identified in the Department of Energy's position paper, 20% Wind Energy by 2030, projected an exploding demand for wind energy-related workforce development. These primary assumptions drove a secondary set of assumptions that early stage wind industry workforce development and training paradigms would need to undergo significant change if the workforce needs were to be met. The current training practice and culture within the wind industry is driven by a relatively small number of experts with deep field experience and knowledge. The current training methodology is dominated by face-to-face, classroom based, instructor present training. Given these assumptions and learning paradigms, the purpose of the National Wind Distance Learning Collaborative was to determine the feasibility of developing online learning strategies and products focused on training wind technicians. The initial project scope centered on (1) identifying resources that would be needed for development of subject matter and course design/delivery strategies for industry-based (non-academic) training, and (2) development of an appropriate Learning Management System (LMS). As the project unfolded, the initial scope was expanded to include development of learning products and the addition of an academic-based training partner. The core partners included two training entities, industry-based Airstreams Renewables and academic-based Lake Area Technical Institute. A third partner, Vision Video Interactive, Inc. provided technology-based learning platforms (hardware and software). The revised scope yielded an expanded set of results beyond the initial expectation. Eight learning modules were developed for the industry-based Electrical Safety course. These modules were subsequently redesigned and repurposed for test application in an academic setting. Software and hardware developments during the project's timeframe enabled redesign providing for
NuMI Low Energy Flux Prediction Release
U.S. Department of Energy (DOE) - all webpages (Extended Search)
NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV
miRNA-205 affects infiltration and metastasis of breast cancer
Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xi�an 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong
Highlights: �We detected expression of miR-205 in breast cancer cell lines and tissue samples. �We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. �We suggest the lower expression of miR-205 play a role in breast cancer onset. �These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.
Mayda M. Velasco; Michal Szleper
Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra
Urban structure and its influence on vehicle travel reduction strategies
Southworth, F.; Jones, D.W.; Harrison, G.
This paper examines what is known about the relationship between urban spatial structure (i.e. the arrangement of residential, industrial, commercial, recreational and municipal buildings and land lots) and urban travel. The first section provides an overview of the empirical evidence for relationships between urban spatial structure and travel in the United States. Section two focuses on the barriers to and opportunities for reducing the use of automobiles and light trucks in urban areas. The final section offers a policy-point-of-impact perspective on the sort of instruments governments have at their disposal for reducing vehicular travel.
2-D traveling-wave patterns in binary fluid convection
Surko, C.M.; Porta, A.L.
An overview is presented of recent experiments designed to study two-dimensional traveling-wave convection in binary fluid convection in a large aspect ratio container. Disordered patterns are observed when convection is initiated. As time proceeds, they evolve to more ordered patterns, consisting of several domains of traveling-waves separated by well-defined domain boundaries. The detailed character of the patterns depends sensitively on the Rayleigh number. Numerical techniques are described which were developed to provide a quantitative characterization of the traveling-wave patterns. Applications of complex demodulation techniques are also described, which make a detailed study of the structure and dynamics of the domain boundaries possible.
DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14
Office of Legacy Management (LM)
1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...
DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14
Office of Legacy Management (LM)
1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...
Energy Secretary Moniz to Travel to Los Angeles for Events Focusing...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Travel to Los Angeles for Events Focusing on Clean Energy Innovation and Climate Change Energy Secretary Moniz to Travel to Los Angeles for Events Focusing on Clean Energy ...
Optical Distance Measurement Device And Method Thereof
Bowers, Mark W.
A system and method of efficiently obtaining distance measurements of a target by scanning the target. An optical beam is provided by a light source and modulated by a frequency source. The modulated optical beam is transmitted to an acousto-optical deflector capable of changing the angle of the optical beam in a predetermined manner to produce an output for scanning the target. In operation, reflected or diffused light from the target may be received by a detector and transmitted to a controller configured to calculate the distance to the target as well as the measurement uncertainty in calculating the distance to the target.
MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis
Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian
MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.
Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...
Energy Information Administration (EIA) (indexed site)
(Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...
Neutron scattering study of spin ordering and stripe pinning in superconducting
Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.
The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 ⁻30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.
Quantifying EV battery end-of-life through analysis of travel needs with vehicle powertrain models
Saxena, Samveg; Le Floch, Caroline; MacDonald, Jason; Moura, Scott
Electric vehicles enable clean and efficient transportation; however, concerns about range anxiety and battery degradation hinder EV adoption. The common definition for battery end-of-life is when 70-80% of original energy capacity remain;, however, little analysis is available to support this retirement threshold. By applying detailed physics-based models of EVs with data on how drivers use their cars, we show that EV batteries continue to meet daily travel needs of drivers well beyond capacity fade of 80% remaining energy storage capacity. Further, we show that EV batteries with substantial energy capacity fade continue to provide sufficient buffer charge for unexpected tripsmore » with long distances. We show that enabling charging in more locations, even if only with 120 V wall outlets, prolongs useful life of EV batteries. Battery power fade is also examined and we show EVs meet performance requirements even down to 30% remaining power capacity. Our findings show that defining battery retirement at 70-80% remaining capacity is inaccurate. Battery retirement should instead be governed by when batteries no longer satisfy daily travel needs of a driver. Using this alternative retirement metric, we present results on the fraction of EV batteries that may be retired with different levels of energy capacity fade.« less
Quantifying EV battery end-of-life through analysis of travel needs with vehicle powertrain models
Saxena, Samveg; Le Floch, Caroline; MacDonald, Jason; Moura, Scott
Electric vehicles enable clean and efficient transportation; however, concerns about range anxiety and battery degradation hinder EV adoption. The common definition for battery end-of-life is when 70-80% of original energy capacity remain;, however, little analysis is available to support this retirement threshold. By applying detailed physics-based models of EVs with data on how drivers use their cars, we show that EV batteries continue to meet daily travel needs of drivers well beyond capacity fade of 80% remaining energy storage capacity. Further, we show that EV batteries with substantial energy capacity fade continue to provide sufficient buffer charge for unexpected trips with long distances. We show that enabling charging in more locations, even if only with 120 V wall outlets, prolongs useful life of EV batteries. Battery power fade is also examined and we show EVs meet performance requirements even down to 30% remaining power capacity. Our findings show that defining battery retirement at 70-80% remaining capacity is inaccurate. Battery retirement should instead be governed by when batteries no longer satisfy daily travel needs of a driver. Using this alternative retirement metric, we present results on the fraction of EV batteries that may be retired with different levels of energy capacity fade.
Travel Patterns And Characteristics Of Transit Users In New York State
Hwang, Ho-Ling; Wilson, Daniel W.; Reuscher, Tim; Chin, Shih-Miao; Taylor, Rob D.
This research is a detailed examination of the travel behaviors and patterns of transit users within New York State (NYS), primarily based on travel data provided by the National Household Travel Survey (NHTS) in 2009 and the associated Add-on sample households purchased by the New York State Department of Transportation (NYSDOT). Other data sources analyzed in this study include: NYS General Transit Feed Specification (GTFS) to assist in analyzing spatial relationships for access to transit and the creation of Transit Shed geographic areas of 1, 2.5, and 5 miles from transit stop locations, LandScan population database to understand transit coverage, and Census Bureau s American Community Survey (ACS) data to examine general transit patterns and trends in NYS over time. The majority of analyses performed in this research aimed at identifying transit trip locations, understanding differences in transit usage by traveler demographics, as well as producing trip/mode-specific summary statistics including travel distance, trip duration, time of trip, and travel purpose of transit trips made by NYS residents, while also analyzing regional differences and unique travel characteristics and patterns. The analysis was divided into two aggregated geographic regions: New York Metropolitan Transportation Council (NYMTC) and NYS minus NYMTC (Rest of NYS). The inclusion of NYMTC in all analysis would likely produce misleading conclusions for other regions in NYS. TRANSIT COVERAGE The NYS transit network has significant coverage in terms of transit stop locations across the state s population. Out of the 19.3 million NYS population in 2011, about 15.3 million (or 79%) resided within the 1-mile transit shed. This NYS population transit coverage increased to 16.9 million (or 88%) when a 2.5-mile transit shed was considered; and raised to 17.7 million (or 92%) when the 5-mile transit shed was applied. KEY FINDINGS Based on 2009 NHTS data, about 40% of NYMTC households used transit
MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma
Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng
The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.
Deputy Secretary Poneman to Travel to Russia | Department of...
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Washington, D.C. - On Monday, December 6, U.S. Deputy Secretary of Energy Daniel Poneman will travel to Russia as part of the ongoing cooperation between the two countries on ...
ORISE: CDC Travelers' Health Team Receives Innovation Award for...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
CDC Travelers' Health Team Receives Innovation Award for Website Redesign ORISE serves as lead redesign contractor on award-winning website redesign for the CDC How ORISE is Making...
U.S. Department of Energy Travel Manual
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The Manual supplements information in the Federal Travel Regulation (FTR) by providing further clarification and establishing Department of Energy (DOE) policy on matters that the FTR left to Agency discretion. Supersedes DOE M 552.1-1.
U.S. Department of Energy Travel Manual
Directives, Delegations, and Other Requirements [Office of Management (MA)]
To supplement information contained in the Federal Travel Regulation (FTR) by providing further clarification and establishing Department of Energy (DOE) policy on matters that the FTR left to Agency discretion. Canceled by DOE M 552.1-1A.
Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level
Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya
Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.
MONDAY: Secretary Chu Travels to New Jersey and Philadelphia | Department
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
of Energy MONDAY: Secretary Chu Travels to New Jersey and Philadelphia MONDAY: Secretary Chu Travels to New Jersey and Philadelphia September 24, 2010 - 12:00am Addthis WASHINGTON - On Monday, September 27, 2010, U.S. Energy Secretary Steven Chu and Representative Rush Holt will tour Applied Photovoltaics. With help from a Recovery Act-funded $1.1 million clean energy manufacturing tax credit, Applied Photovoltaics will manufacture solar energy modules for use in building-integrated
The Department of Energy's Management of Foreign Travel, IG-0872
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
The Department of Energy's Management of Foreign Travel DOE/IG-0872 October 2012 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 October 16, 2012 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Management Alert: "The Department of Energy's Management of Foreign Travel" INTRODUCTION The Department of Energy and its workforce of 116,000 Federal and contractor
NNSA Administrator D'Agostino's Safeguards Conference Travel Blog |
National Nuclear Security Administration (NNSA)
National Nuclear Security Administration | (NNSA) Administrator D'Agostino's Safeguards Conference Travel Blog Follow the second international meeting in Tokai-mura, Ibaraki Japan Follow the second international meeting in Tokai-mura, Ibaraki Japan This week, NNSA Administrator Thomas D'Agostino attended the second international meeting on Next Generation Safeguards in Tokai-mura, Ibaraki Japan. This page documents the Administrator's travels as he promoted NNSA's safeguards programs and
NNSA deputy administrator travels to Ukraine | National Nuclear Security
National Nuclear Security Administration (NNSA)
Administration | (NNSA) administrator travels to Ukraine Thursday, April 14, 2016 - 10:02am From left, NNSA Director of Strategic Planning/Integration Andy Hood, STCU Executive Director Curtis Bjelajac, NNSA Deputy Administrator Anne Harrington, and NNSA Assistant Deputy Administrator Pete Hanlon. Earlier this month, Deputy Administrator for Defense Nuclear Nonproliferation Anne Harrington traveled to Ukraine to celebrate the 20th anniversary of the Science and Technology Center in Ukraine
Permutation-invariant distance between atomic configurations
Ferré, Grégoire; Maillet, Jean-Bernard; Stoltz, Gabriel
We present a permutation-invariant distance between atomic configurations, defined through a functional representation of atomic positions. This distance enables us to directly compare different atomic environments with an arbitrary number of particles, without going through a space of reduced dimensionality (i.e., fingerprints) as an intermediate step. Moreover, this distance is naturally invariant through permutations of atoms, avoiding the time consuming associated minimization required by other common criteria (like the root mean square distance). Finally, the invariance through global rotations is accounted for by a minimization procedure in the space of rotations solved by Monte Carlo simulated annealing. A formal framework is also introduced, showing that the distance we propose verifies the property of a metric on the space of atomic configurations. Two examples of applications are proposed. The first one consists in evaluating faithfulness of some fingerprints (or descriptors), i.e., their capacity to represent the structural information of a configuration. The second application concerns structural analysis, where our distance proves to be efficient in discriminating different local structures and even classifying their degree of similarity.
EERE Success Story—Thurston Regional Planning Council Helps Washingtonians Save on Travel Costs
Thurston County provides travel information for lower costs, improved safety, and faster response to challenges.
Verification of the helioseismology travel-time measurement technique and the inversion procedure for sound speed using artificial data
Parchevsky, K. V.; Zhao, J.; Hartlep, T.; Kosovichev, A. G.
We performed three-dimensional numerical simulations of the solar surface acoustic wave field for the quiet Sun and for three models with different localized sound-speed perturbations in the interior with deep, shallow, and two-layer structures. We used the simulated data generated by two solar acoustics codes that employ the same standard solar model as a background model, but utilize different integration techniques and different models of stochastic wave excitation. Acoustic travel times were measured using a time-distance helioseismology technique, and compared with predictions from ray theory frequently used for helioseismic travel-time inversions. It is found that the measured travel-time shifts agree well with the helioseismic theory for sound-speed perturbations, and for the measurement procedure with and without phase-speed filtering of the oscillation signals. This testing verifies the whole measuring-filtering-inversion procedure for static sound-speed anomalies with small amplitude inside the Sun outside regions of strong magnetic field. It is shown that the phase-speed filtering, frequently used to extract specific wave packets and improve the signal-to-noise ratio, does not introduce significant systematic errors. Results of the sound-speed inversion procedure show good agreement with the perturbation models in all cases. Due to its smoothing nature, the inversion procedure may overestimate sound-speed variations in regions with sharp gradients of the sound-speed profile.
Yoshii, Yuzuru; Minezaki, Takeo; Kobayashi, Yukiyasu; Koshida, Shintaro; Peterson, Bruce A.
We have pioneered a new method for the measurement of extragalactic distances. This method uses the time lag between variations in the short wavelength and long wavelength light from an active galactic nucleus (AGN), based on a quantitative physical model of dust reverberation that relates the time lag to the absolute luminosity of the AGN. We use the large homogeneous data set from intensive monitoring observations in optical and near-infrared wavelength bands with the dedicated 2 m MAGNUM telescope to obtain the distances to 17 AGNs in the redshift range z = 0.0024 to z = 0.0353. These distance measurements are compared with distances measured using Cepheid variable stars, and are used to infer that H {sub 0} = 73 ± 3 (random) km s{sup –1} Mpc{sup –1}. The systematic error in H {sub 0} is examined, and the uncertainty in the size distribution of dust grains is the largest source of the systematic error, which is much reduced for a sample of AGNs for which their parameter values in the model of dust reverberation are individually measured. This AGN time lag method can be used beyond 30 Mpc, the farthest distance reached by extragalactic Cepheids, and can be extended to high-redshift quasi-stellar objects.
Modeling highway travel time distribution with conditional probability models
Oliveira Neto, Francisco Moraes; Chin, Shih-Miao; Hwang, Ho-Ling; Han, Lee
ABSTRACT Under the sponsorship of the Federal Highway Administration's Office of Freight Management and Operations, the American Transportation Research Institute (ATRI) has developed performance measures through the Freight Performance Measures (FPM) initiative. Under this program, travel speed information is derived from data collected using wireless based global positioning systems. These telemetric data systems are subscribed and used by trucking industry as an operations management tool. More than one telemetric operator submits their data dumps to ATRI on a regular basis. Each data transmission contains truck location, its travel time, and a clock time/date stamp. Data from the FPM program provides a unique opportunity for studying the upstream-downstream speed distributions at different locations, as well as different time of the day and day of the week. This research is focused on the stochastic nature of successive link travel speed data on the continental United States Interstates network. Specifically, a method to estimate route probability distributions of travel time is proposed. This method uses the concepts of convolution of probability distributions and bivariate, link-to-link, conditional probability to estimate the expected distributions for the route travel time. Major contribution of this study is the consideration of speed correlation between upstream and downstream contiguous Interstate segments through conditional probability. The established conditional probability distributions, between successive segments, can be used to provide travel time reliability measures. This study also suggests an adaptive method for calculating and updating route travel time distribution as new data or information is added. This methodology can be useful to estimate performance measures as required by the recent Moving Ahead for Progress in the 21st Century Act (MAP 21).
Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions
Numerous transportation strategies are directed at reducing energy use and greenhouse gas (GHG) emissions by changing the behavior of individual drivers or travelers. These behavioral changes may have the effect of reducing travel, shifting travel to more efficient modes, or improving the efficiency of existing travel. Since the 1970s, federal, regional, state and municipal agencies have tried to reduce energy use, emissions, and congestion by influencing travel behavior. This report reviews and summarizes the literature on relationships between these strategies and transportation-related energy use and GHG emissions to examine how changes to travel behavior can reduce transportation energy use and discuss the potential for federal actions to affect travel behavior.
PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b
Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan
miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.
A technical review of urban land use - transportation models as tools for evaluating vehicle travel reduction strategies
Southworth, F.
The continued growth of highway traffic in the United States has led to unwanted urban traffic congestion as well as to noticeable urban air quality problems. These problems include emissions covered by the 1990 Clean Air Act Amendments (CAAA) and 1991 Intermodal Surface Transportation Efficiency Act (ISTEA), as well as carbon dioxide and related {open_quotes}greenhouse gas{close_quotes} emissions. Urban travel also creates a major demand for imported oil. Therefore, for economic as well as environmental reasons, transportation planning agencies at both the state and metropolitan area level are focussing a good deal of attention on urban travel reduction policies. Much discussed policy instruments include those that encourage fewer trip starts, shorter trip distances, shifts to higher-occupancy vehicles or to nonvehicular modes, and shifts in the timing of trips from the more to the less congested periods of the day or week. Some analysts have concluded that in order to bring about sustainable reductions in urban traffic volumes, significant changes will be necessary in the way our households and businesses engage in daily travel. Such changes are likely to involve changes in the ways we organize and use traffic-generating and-attracting land within our urban areas. The purpose of this review is to evaluate the ability of current analytic methods and models to support both the evaluation and possibly the design of such vehicle travel reduction strategies, including those strategies involving the reorganization and use of urban land. The review is organized into three sections. Section 1 describes the nature of the problem we are trying to model, Section 2 reviews the state of the art in operational urban land use-transportation simulation models, and Section 3 provides a critical assessment of such models as useful urban transportation planning tools. A number of areas are identified where further model development or testing is required.
Traveling solitons in Lorentz and CPT breaking systems
Souza Dutra, A. de; Correa, R. A. C.
In this work we present a class of traveling solitons in Lorentz and CPT breaking systems. In the case of Lorentz violating scenarios, as far as we know, only static solitonic configurations were analyzed up to now in the literature. Here it is shown that it is possible to construct some traveling solitons which cannot be mapped into static configurations by means of Lorentz boosts due to explicit breaking. In fact, the traveling solutions cannot be reached from the static ones by using something similar to a Lorentz boost in those cases. Furthermore, in the model studied, a complete set of exact solutions is obtained. The solutions present a critical behavior controlled by the choice of an arbitrary integration constant.
Bifurcations of traveling wave solutions for an integrable equation
Li Jibin; Qiao Zhijun
This paper deals with the following equation m{sub t}=(1/2)(1/m{sup k}){sub xxx}-(1/2)(1/m{sup k}){sub x}, which is proposed by Z. J. Qiao [J. Math. Phys. 48, 082701 (2007)] and Qiao and Liu [Chaos, Solitons Fractals 41, 587 (2009)]. By adopting the phase analysis method of planar dynamical systems and the theory of the singular traveling wave systems to the traveling wave solutions of the equation, it is shown that for different k, the equation may have infinitely many solitary wave solutions, periodic wave solutions, kink/antikink wave solutions, cusped solitary wave solutions, and breaking loop solutions. We discuss in a detail the cases of k=-2,-(1/2),(1/2),2, and parametric representations of all possible bounded traveling wave solutions are given in the different (c,g)-parameter regions.
Assessing Energy Impact of Plug-In Hybrid Electric Vehicles: Significance of Daily Distance Variation over Time and Among Drivers
Lin, Zhenhong [ORNL; Greene, David L [ORNL
Accurate assessment of the impact of plug-in hybrid electric vehicles (PHEVs) on petroleum and electricity consumption is a necessary step toward effective policies. Variations in daily vehicle miles traveled (VMT) over time and among drivers affect PHEV energy impact, but the significance is not well understood. This paper uses a graphical illustration, a mathematical derivation, and an empirical study to examine the cause and significance of such an effect. The first two methods reveal that ignoring daily variation in VMT always causes underestimation of petroleum consumption and overestimation of electricity consumption by PHEVs; both biases increase as the assumed PHEV charge-depleting (CD) range moves closer to the average daily VMT. The empirical analysis based on national travel survey data shows that the assumption of uniform daily VMT over time and among drivers causes nearly 68% underestimation of expected petroleum use and nearly 48% overestimation of expected electricity use by PHEVs with a 40-mi CD range (PHEV40s). Also for PHEV40s, consideration of daily variation in VMT over time but not among drivers similar to the way the utility factor curve is derived in SAE Standard SAE J2841 causes underestimation of expected petroleum use by more than 24% and overestimation of expected electricity use by about 17%. Underestimation of petroleum use and overestimation of electricity use increase with larger-battery PHEVs.
Secretary Chu Travels to Memphis | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Travels to Memphis Secretary Chu Travels to Memphis January 31, 2011 - 2:33pm Addthis Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs What does this project do? The Sharp solar manufacturing plant has produced more than 2 million solar panels since 2002, increased its staff from 300 to 480 employees over the last year, and produces enough solar paneling to power more than 140,000 homes. Worldwide, FedEx Express is operating 329 hybrid and 19
Fact #729: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy 9: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles Fact #729: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles When a household has more than one vehicle, the secondary vehicles travel fewer miles than the primary vehicle. In a two-vehicle household, the second vehicle travels less than half of the miles that the primary vehicle travels in a day. In a six-vehicle household, the sixth vehicle travels fewer than five miles a day. Daily Vehicle
Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops
Green, Pamela J.
MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.
DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1
Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.
Long working distance incoherent interference microscope
Sinclair, Michael B.; De Boer, Maarten P.
A full-field imaging, long working distance, incoherent interference microscope suitable for three-dimensional imaging and metrology of MEMS devices and test structures on a standard microelectronics probe station. A long working distance greater than 10 mm allows standard probes or probe cards to be used. This enables nanometer-scale 3-dimensional height profiles of MEMS test structures to be acquired across an entire wafer while being actively probed, and, optionally, through a transparent window. An optically identical pair of sample and reference arm objectives is not required, which reduces the overall system cost, and also the cost and time required to change sample magnifications. Using a LED source, high magnification (e.g., 50.times.) can be obtained having excellent image quality, straight fringes, and high fringe contrast.
U.S. Department of Energy (DOE) - all webpages (Extended Search)
NERSC Storage Systems Group Storage at a Distance --- 1 --- Open F abrics A lliance U ser D ay What is storage at a distance? * Data i s n ot l ocal t o t he u ser/resource * Processing a nd w orkflow n eeds a re n ear r eal---7me - Don't w ant t o w ait u n9l d ata t ransfer i s c omplete - Need t o s ee r esults, m ake a djustments, a nd t ry a gain * Network w ill b ecome p art o f t he i nstruments - Telescopes a nd t heir d ata - Sequencers a nd t heir g enome d ata - Light s ources a nd t
Topological horseshoes in travelling waves of discretized nonlinear wave equations
Chen, Yi-Chiuan; Chen, Shyan-Shiou; Yuan, Juan-Ming
Applying the concept of anti-integrable limit to coupled map lattices originated from space-time discretized nonlinear wave equations, we show that there exist topological horseshoes in the phase space formed by the initial states of travelling wave solutions. In particular, the coupled map lattices display spatio-temporal chaos on the horseshoes.
Flow calculations for Yucca Mountain groundwater travel time (GWTT-95)
Altman, S.J.; Arnold, B.W.; Barnard, R.W.; Barr, G.E.; Ho, C.K.; McKenna, S.A.; Eaton, R.R.
In 1983, high-level radioactive waste repository performance requirements related to groundwater travel time were defined by NRC subsystem regulation 10 CFR 60.113. Although DOE is not presently attempting to demonstrate compliance with that regulation, understanding of the prevalence of fast paths in the groundwater flow system remains a critical element of any safety analyses for a potential repository system at Yucca Mountain, Nevada. Therefore, this analysis was performed to allow comparison of fast-path flow against the criteria set forth in the regulation. Models developed to describe the conditions for initiation, propagation, and sustainability of rapid groundwater movement in both the unsaturated and saturated zones will form part of the technical basis for total- system analyses to assess site viability and site licensability. One of the most significant findings is that the fastest travel times in both unsaturated and saturated zones are in the southern portion of the potential repository, so it is recommended that site characterization studies concentrate on this area. Results support the assumptions regarding the importance of an appropriate conceptual model of groundwater flow and the incorporation of heterogeneous material properties into the analyses. Groundwater travel times are sensitive to variation/uncertainty in hydrologic parameters and in infiltration flux at upper boundary of the problem domain. Simulated travel times are also sensitive to poorly constrained parameters of the interaction between flow in fractures and in the matrix.
Apparatus and method for measuring and imaging traveling waves
Telschow, Kenneth L.; Deason, Vance A.
An apparatus is provided for imaging traveling waves in a medium. The apparatus includes a vibration excitation source configured to impart traveling waves within a medium. An emitter is configured to produce two or more wavefronts, at least one wavefront modulated by a vibrating medium. A modulator is configured to modulate another wavefront in synchronization with the vibrating medium. A sensing media is configured to receive in combination the modulated one wavefront and the another wavefront and having a detection resolution within a limited bandwidth. The another wavefront is modulated at a frequency such that a difference frequency between the one wavefront and the another wavefront is within a response range of the sensing media. Such modulation produces an image of the vibrating medium having an output intensity that is substantially linear with small physical variations within the vibrating medium for all vibration frequencies above the sensing media's response bandwidth. A detector is configured to detect an image of traveling waves in the vibrating medium resulting from interference between the modulated one wavefront and the another wavefront when combined in association with the sensing media. The traveling wave can be used to characterize certain material properties of the medium. Furthermore, a method is provided for imaging and characterizing material properties according to the apparatus.
Microfluidic Molecular Assay Platform for the Detection of miRNAs...
Office of Scientific and Technical Information (OSTI)
Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...
DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13
Office of Legacy Management (LM)
Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...
What is the distance to the CMB?
Clarkson, Chris; Umeh, Obinna; Maartens, Roy; Durrer, Ruth E-mail: firstname.lastname@example.com E-mail: firstname.lastname@example.com
The success of precision cosmology depends not only on accurate observations, but also on the theoretical model --- which must be understood to at least the same level of precision. Subtle relativistic effects can lead to biased measurements if they are neglected. One such effect gives a systematic shift in the distance-redshift relation away from its background value, due to the non-linear relativistic conservation of total photon flux. We also show directly how this shift follows from a fully relativistic analysis of the geodesic deviation equation. We derive the expectation value of the shift using second-order perturbations about a concordance background, and show that the distance to last scattering is increased by 1%. We argue that neglecting this shift could lead to a significant bias in the background cosmological parameters, because it alters the meaning of the background model. A naive adjustment of CMB parameter estimation if this shift is really a correction to the background would raise the H{sub 0} value inferred from the CMB by 5%, potentially removing the tension with local measurements of H{sub 0}. Other CMB parameters which depend on the distance would also be shifted by ? 1? when combined with local H{sub 0} data. While our estimations rely on a simplistic analysis, they nevertheless illustrate that accurately defining the background model in terms of the expectation values of observables is critical when we aim to determine the model parameters at the sub-percent level.
miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A
Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang
MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.
Groundwater protection for the NuMI project
Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.
The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.
Will We Drive Less? A White Paper on U.S. Light Duty Travel ...
U.S. Department of Energy (DOE) - all webpages (Extended Search)
vehicle travel in the U.S. and other developed nations, with VMT likely stagnating or dropping in the future. This report examines a variety of issues surrounding light-duty travel...
Fact #640: September 13, 2010 Monthly Trends in Vehicle Miles of Travel
Vehicle travel in the U.S. varies by month. There are many reasons for this, including the fact that some months are shorter than others. The vehicle miles of travel (VMT) recorded in February is...
Fact #842: October 13, 2014 Vehicles and Vehicle Travel Trends have Changed Since 2008
As the U.S. population has doubled from 1950 to 2012, the number of vehicles has grown nearly 6-fold and vehicle travel even more than that. The number of vehicles and vehicle travel peaked in 2007...
How Do You Go Green When You Travel? | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Choices such as less frequent linen service are opportunities to save water and energy while traveling. How do you go green when you travel? E-mail your responses to the Energy ...
Fact# 904: December 21, 2015 Gross Domestic Product and Vehicle Travel:
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Both Increased during 2015 | Department of Energy 4: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 Fact# 904: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 SUBSCRIBE to the Fact of the Week The nation's highway vehicle miles of travel (VMT) and the U.S. gross domestic product (GDP) reflect strikingly similar patterns, indicating the strong relationship between the nation's economy and its travel. Beginning in
Microsoft Word - gra-ugs-program-travel-regs-tr9003.doc
U.S. Department of Energy (DOE) - all webpages (Extended Search)
......... 4 3.4.3 Rental Car Travel ......including lodging, meals, rental car, and private vehicle mileage are reimbursable. ...
Table 10 Costs of Foreign Travel, IG-0397 | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Table 10 Costs of Foreign Travel, IG-0397 Table 10 Costs of Foreign Travel, IG-0397 Table 10 Costs of Foreign Travel, IG-0397 Table 10 Costs of Foreign Travel, IG-0397 (242.36 KB) More Documents & Publications Inspection Report: IG-0397 Audit of Department of Energy International Charter Flights, IG-0397 John C. Layton: Before The Subcommittee on Oversight and Investigations Committee on Commerce
MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19
Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun
Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.
miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma
Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong
Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3'-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.
Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells
Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun
Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.
NEW - DOE O 551.1D Chg 1 (PgChg), Official Foreign Travel
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The requirement to surrender official passports is considered burdensome to travelers and will be removed as a requirement and replaced with a process that requires travelers be responsible for safeguarding their own official passports. In conjunction with this revision, administrative changes will be made to update the title of the Office of Travel Management.
miR-1297 mediates PTEN expression and contributes to cell progression in LSCC
Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin
Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.
Attenuation of hydrogen radicals traveling under flowing gas conditions through tubes of different materials
Grubbs, R.K.; George, S.M.
Hydrogen radical concentrations traveling under flowing gas conditions through tubes of different materials were measured using a dual thermocouple probe. The source of the hydrogen radicals was a toroidal radio frequency plasma source operating at 2.0 and 3.3 kW for H{sub 2} pressures of 250 and 500 mTorr, respectively. The dual thermocouple probe was comprised of exposed and covered Pt/Pt13%Rh thermocouples. Hydrogen radicals recombined efficiently on the exposed thermocouple and the energy of formation of H{sub 2} heated the thermocouple. The second thermocouple was covered by glass and was heated primarily by the ambient gas. The dual thermocouple probe was translated and measured temperatures at different distances from the hydrogen radical source. These temperature measurements were conducted at H{sub 2} flow rates of 35 and 75 SCCM (SCCM denotes cubic centimeter per minute at STP) inside cylindrical tubes made of stainless steel, aluminum, quartz, and Pyrex. The hydrogen radical concentrations were obtained from the temperatures of the exposed and covered thermocouples. The hydrogen concentration decreased versus distance from the plasma source. After correcting for the H{sub 2} gas flow using a reference frame transformation, the hydrogen radical concentration profiles yielded the atomic hydrogen recombination coefficient, {gamma}, for the four materials. The methodology of measuring the hydrogen radical concentrations, the analysis of the results under flowing gas conditions, and the determination of the atomic hydrogen recombination coefficients for various materials will help facilitate the use of hydrogen radicals for thin film growth processes.
miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2
Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui
Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.
Inspection of the Secretary of Energy`s foreign travel
On December 9, 1995, the Secretary of Energy requested that the Department`s Inspector General (IG) conduct a thorough examination of all Secretarial foreign travel from 1993 to December 1995 to include the purpose of each trip, the activities of each Federal participant in each trip, the funding of each trip, and claims for reimbursements for expenses by Federal trip participants. The Secretary also requested that the review include an assessment of travel authorization, voucher, traveler reimbursement, and auditing systems employed by the Department to identify steps that could be taken to reduce errors and improve accounting oversight. Additionally, the Secretary requested that the Inspector General conduct a thorough examination of the establishment and filling of the Department`s Ombudsman position. The Office of Inspector General (OIG) initiated a review into these matters and assigned primary responsibility for the review to the Office of Inspections. The purpose of this inspection was to conduct a thorough examination of the 16 Secretarial foreign trips from June 1993 to December 1995. This report focuses on the four trade missions because of their extent and cost. We examined a number of Departmental management systems and processes involved in planning and executing the 16 foreign trips. To determine the actual cost of the 16 trips, it was necessary to determine who participated in the trips and to identify the individual travel costs. We were required to perform extensive reviews of records and conduct a large number of interviews because the Department could not provide any specific documents that could accurately account for who actually participated on the 16 trips. Having identified who participated, it was then necessary to examine key aspects of the Department`s management systems. Our report contains 31 recommendations for corrective action.
Brain teasers traveling exhibit opens at Los Alamos National Laboratory's
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Bradbury Science Museum Brain teasers exhibit opens at museum Brain Teasers traveling exhibit opens at Los Alamos National Laboratory's Bradbury Science Museum The interactive exhibit is a collection of more than 20 puzzles and mind benders. December 4, 2008 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma
Tiny travelers from deep space could assist in healing Fukushima's
U.S. Department of Energy (DOE) - all webpages (Extended Search)
nuclear scar Fukushima Daiichi nuclear reactors Tiny travelers from deep space could assist in healing Fukushima's nuclear scar Researchers have devised a method to use cosmic rays to gather detailed information from inside the damaged cores of the Fukushima Daiichi nuclear reactors. October 17, 2012 Los Alamos National Laboratory Muon Radiography team members stand in front of the damaged Fukushima Daiichi reactor complex during a visit to determine evaluate whether Los Alamos' Scattering
Molten metal feed system controlled with a traveling magnetic field
Praeg, Walter F.
A continuous metal casting system in which the feed of molten metal is controlled by means of a linear induction motor capable of producing a magnetic traveling wave in a duct that connects a reservoir of molten metal to a caster. The linear induction motor produces a traveling magnetic wave in the duct in opposition to the pressure exerted by the head of molten metal in the reservoir so that p.sub.c =p.sub.g -p.sub.m where p.sub.c is the desired pressure in the caster, p.sub.g is the gravitational pressure in the duct exerted by the force of the head of molten metal in the reservoir, and p.sub.m is the electromagnetic pressure exerted by the force of the magnetic field traveling wave produced by the linear induction motor. The invention also includes feedback loops to the linear induction motor to control the casting pressure in response to measured characteristics of the metal being cast.
miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1
Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan
Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.
miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7
Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi
MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.
DOE Premium Class Travel Report for FY 09 through FY 15 | Department of
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Energy Premium Class Travel Report for FY 09 through FY 15 DOE Premium Class Travel Report for FY 09 through FY 15 This report was provided to the FOIA office in response to several FOIA requests. DOEPremiumClassTravelReportsFY09-FY13.pdf (4.6 MB) DOE_PREMIUM_CLASS_TRAVEL_REPORTS_FY14.pdf (184.26 KB) DOE_PREMIUM_CLASS_TRAVEL_REPORTS_FY15.pdf (256.46 KB) More Documents & Publications ISSUANCE 2015-07-15: Energy Conservation Program: Test Procedure for Refrigerated Bottled or Canned
Moradi, Hamed; Cally, Paul S.
The rapid exponential increase in the Alfv�n wave speed with height above the solar surface presents a serious challenge to physical modeling of the effects of magnetic fields on solar oscillations, as it introduces a significant Courant-Friedrichs-Lewy time-step constraint for explicit numerical codes. A common approach adopted in computational helioseismology, where long simulations in excess of 10 hr (hundreds of wave periods) are often required, is to cap the Alfv�n wave speed by artificially modifying the momentum equation when the ratio between the Lorentz and hydrodynamic forces becomes too large. However, recent studies have demonstrated that the Alfv�n wave speed plays a critical role in the MHD mode conversion process, particularly in determining the reflection height of the upwardly propagating helioseismic fast wave. Using numerical simulations of helioseismic wave propagation in constant inclined (relative to the vertical) magnetic fields we demonstrate that the imposition of such artificial limiters significantly affects time-distance travel times unless the Alfv�n wave-speed cap is chosen comfortably in excess of the horizontal phase speeds under investigation.
The solar neighborhood. XXXV. Distances to 1404 M dwarf systems...
Office of Scientific and Technical Information (OSTI)
solar neighborhood. XXXV. Distances to 1404 M dwarf systems within 25 PC in the southern sky Citation Details In-Document Search Title: The solar neighborhood. XXXV. Distances to...
Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic
Energy Information Administration (EIA) (indexed site)
Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli
Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per
Energy Information Administration (EIA) (indexed site)
Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas
NuMI proton kicker extraction magnet termination resistor system
Reeves, S.R.; Jensen, C.C.; /Fermilab
The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.
Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells
Kim, Byeong-Moo; Choi, Michael Y.
Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.
Travel determinants and multi-scale transferability of national activity patterns to local populations
Henson, Kriste M; Gou; ias, Konstadinos G
The ability to transfer national travel patterns to a local population is of interest when attempting to model megaregions or areas that exceed metropolitan planning organization (MPO) boundaries. At the core of this research are questions about the connection between travel behavior and land use, urban form, and accessibility. As a part of this process, a group of land use variables have been identified to define activity and travel patterns for individuals and households. The 2001 National Household Travel Survey (NHTS) participants are divided into categories comprised of a set of latent cluster models representing persons, travel, and land use. These are compared to two sets of cluster models constructed for two local travel surveys. Comparison of means statistical tests are used to assess differences among sociodemographic groups residing in localities with similar land uses. The results show that the NHTS and the local surveys share mean population activity and travel characteristics. However, these similarities mask behavioral heterogeneity that are shown when distributions of activity and travel behavior are examined. Therefore, data from a national household travel survey cannot be used to model local population travel characteristics if the goal to model the actual distributions and not mean travel behavior characteristics.
miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma
Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun
Highlights: � miR-182 and CHL1 expression patterns are negatively correlated. � CHL1 is a direct target of miR-182 in PTC cells. � miR-182 suppression inhibits PTC cell growth and invasion. � CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.
Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells
Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo
Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the
miR-128 and its target genes in tumorigenesis and metastasis
Li, Molin, E-mail: email@example.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: firstname.lastname@example.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)
MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18�24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: � Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. � The molecular mechanisms regulating miR-128 expression are elucidated. � Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.
miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation
Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi
Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.
miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer
Office of Scientific and Technical Information (OSTI)
Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.
Secretary Bodman Travels to Russia to Advance Energy Security | Department
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
of Energy Russia to Advance Energy Security Secretary Bodman Travels to Russia to Advance Energy Security March 15, 2006 - 12:20pm Addthis Promotes Transparent Markets and Clean Energy Technologies; Participates in G8 Energy Ministerial and Delivers Remarks on the Global Nuclear Energy Partnership MOSCOW, RUSSIA-U.S. Secretary of Energy Samuel W. Bodman today began a two-day visit to Russia where he will lead the U.S. delegation to the G8 Energy Ministerial. During his visit the Secretary
Secretary Bodman Travels to Saudi Arabia to Discuss Global Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Investments | Department of Energy Saudi Arabia to Discuss Global Energy Investments Secretary Bodman Travels to Saudi Arabia to Discuss Global Energy Investments January 19, 2007 - 10:38am Addthis Furthers Strategic Energy Dialogue between the Nations and Highlights U.S. - Saudi Scientific Innovation RIYADH, SAUDI ARABIA - U.S. Secretary of Energy Samuel W. Bodman today continued his six-nation visit to the Middle East and Europe with a two-day stop in Saudi Arabia where he met with Saudi
Secretary Bodman Travels to the Middle East | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
the Middle East Secretary Bodman Travels to the Middle East November 10, 2005 - 2:22pm Addthis Four-nation swing to emphasize domestic energy needs and goals WASHINGTON, DC - Secretary of Energy Samuel W. Bodman embarked upon a four-nation tour through the Middle East to enhance the United States' relationship with major oil-producing nations, promote economic liberalization and increased foreign investment in the region, and reaffirm U.S. energy policy goals. "Both consumers and producers
Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting
Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting
miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.
Dual variational principles for nonlinear traveling waves in multifluid plasmas
Webb, G. M.; McKenzie, J. F.; Mace, R. L.; Ko, C. M.; Zank, G. P.
A Hamiltonian description of nonlinear, obliquely propagating traveling waves in a charge neutral, electron-proton, multifluid plasma is developed. The governing equations are written as a dual spatial Hamiltonian system. In the first formulation, the Hamiltonian is identified with the longitudinal, x-momentum flux integral P{sub x}=const, in which the energy integral {epsilon}={epsilon}{sub 0} acts as a constraint, and the Hamiltonian evolution operator is d/dx, where x is the position coordinate in the wave frame. In the second Hamiltonian formulation, the Hamiltonian is proportional to the conserved energy integral {epsilon}, in which the momentum integral P{sub x}=const acts as a constraint, and the Hamiltonian evolution operator d/d{tau}=u{sub x}d/dx is the Lagrangian time derivative where u{sub x} is the x component of the electron and proton fluids. The analysis is facilitated by using the de Hoffman-Teller frame of magnetohydrodynamic shock theory to simplify the transverse electron and proton momentum equations. The system is exactly integrable in cases in which the total transverse momentum fluxes of the system are zero in the de Hoffman-Teller frame. The implications of this constraint for the Alfven Mach number of the traveling wave are discussed. The physical conditions for the formation of whistler oscillitons based on the whistler dispersion equation are discussed.
Traveling waves and their tails in locally resonant granular systems
Xu, H.; Kevrekidis, P. G.; Stefanov, A.
In the present study, we revisit the theme of wave propagation in locally resonant granular crystal systems, also referred to as mass-in-mass systems. We use three distinct approaches to identify relevant traveling waves. In addition, the first consists of a direct solution of the traveling wave problem. The second one consists of the solution of the Fourier tranformed variant of the problem, or, more precisely, of its convolution reformulation (upon an inverse Fourier transform) in real space. Finally, our third approach will restrict considerations to a finite domain, utilizing the notion of Fourier series for important technical reasons, namely themore » avoidance of resonances, which will be discussed in detail. All three approaches can be utilized in either the displacement or the strain formulation. Typical resulting computations in finite domains result in the solitary waves bearing symmetric non-vanishing tails at both ends of the computational domain. Importantly, however, a countably infinite set of anti-resonance conditions is identified for which solutions with genuinely rapidly decaying tails arise.« less
AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...
National Nuclear Security Administration (NNSA)
MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...
File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information
OpenEI (Open Energy Information) [EERE & EIA]
MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...
Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ
Secretary Chu To Travel to Scotland and Ireland | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
To Travel to Scotland and Ireland Secretary Chu To Travel to Scotland and Ireland November 1, 2010 - 12:00am Addthis Washington, D.C. - This week, Secretary Chu will travel to Scotland and Ireland where he will meet with government and academic leaders, as well as American and Irish business leaders who are engaged in clean energy industries. Both Scotland and Ireland share similar energy challenges and resources with the United States, including significant offshore wind energy potential. These
Energy Secretary Bodman Travels to Moscow, Baku, Kiev to Discuss Energy and
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Nuclear Security | Department of Energy Travels to Moscow, Baku, Kiev to Discuss Energy and Nuclear Security Energy Secretary Bodman Travels to Moscow, Baku, Kiev to Discuss Energy and Nuclear Security May 20, 2005 - 12:49pm Addthis Trip Will Focus on World Energy Security, Energy Resource Development, and Nuclear Nonproliferation WASHINGTON, DC -- Secretary of Energy Samuel Bodman next week will travel to Moscow, Russia; Baku, Azerbaijan; and Kiev, Ukraine, where he will hold discussions
Fact #904: December 21, 2015 Gross Domestic Product and Vehicle Travel:
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Both Increased during 2015 - Dataset | Department of Energy Fact #904: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 - Dataset Fact #904: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 - Dataset Excel file and dataset for Gross Domestic Product and Vehicle Travel: Both Increased during 2015 fotw#904_web_rev.xlsx (19.75 KB) More Documents & Publications Vehicle Technologies Office Spring 2016 Quarterly
TEE-0068 - In the Matter of Bowlin Travel Centers, Inc. | Department of
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Energy 8 - In the Matter of Bowlin Travel Centers, Inc. TEE-0068 - In the Matter of Bowlin Travel Centers, Inc. Bowlin Travel Centers, Inc., filed an Application for Exception with the Department of Energy's (DOE) Office of Hearings and Appeals (OHA). The firm requests permanent relief from its requirement to prepare and file the Energy Information Administration (EIA) Form EIA-782B, entitled "Resellers'/Retailers' Monthly Petroleum Product Sales Report." As explained below, we
Fact #552: January 5, 2009 Vehicle Miles of Travel by Region | Department
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
of Energy 2: January 5, 2009 Vehicle Miles of Travel by Region Fact #552: January 5, 2009 Vehicle Miles of Travel by Region Total vehicle miles of travel (VMT) in the U.S. have declined from 2007 to 2008. The latest data available, September 2008, shows a 4.4% decline in travel that varies by region. Comparing September 2007 to September 2008, the South Atlantic and South Gulf regions experienced VMT declines of more than 5%. Total U.S. cumulative VMT for 2008 (January-September) is 3.5%
Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
State | Department of Energy 2: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State SUBSCRIBE to the Fact of the Week In the United States, the U.S. Department of Transportation classifies 3.9 million miles of roadway as rural and 1.2 million miles of roadway as urban. Each state has a different travel pattern affecting the proportion of vehicle miles traveled (VMT) on rural versus urban roads.
Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
State - Dataset | Department of Energy 2: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State - Dataset Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State - Dataset Excel file and dataset for Rural versus Urban Vehicle Miles of Travel by State fotw#902_web.xlsx (177.48 KB) More Documents & Publications Fact #904: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 - Dataset Fact #906: January 4, 2016 VMT
Discovering the Nature of Dark Energy: Towards Better Distances...
Office of Scientific and Technical Information (OSTI)
Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae -- Final Technical Report Filippenko, Alexei Vladimir Univ. California, Berkeley 79...
Discovering the Nature of Dark Energy: Towards Better Distances...
Office of Scientific and Technical Information (OSTI)
the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae -- Final Technical Report Citation Details In-Document Search Title: Discovering the Nature of Dark ...
Traveling-wave device with mass flux suppression
Swift, Gregory W.; Backhaus, Scott N.; Gardner, David L.
A traveling-wave device is provided with the conventional moving pistons eliminated. Acoustic energy circulates in a direction through a fluid within a torus. A side branch may be connected to the torus for transferring acoustic energy into or out of the torus. A regenerator is located in the torus with a first heat exchanger located on a first side of the regenerator downstream of the regenerator relative to the direction of the circulating acoustic energy; and a second heat exchanger located on an upstream side of the regenerator. The improvement is a mass flux suppressor located in the torus to minimize time-averaged mass flux of the fluid. In one embodiment, the device further includes a thermal buffer column in the torus to thermally isolate the heat exchanger that is at the operating temperature of the device.
miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells
Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang
Highlights: �miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. �miR-196a expression elevated proliferation and migration of cervical cancer cells. �miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. �NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. �NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 2�3 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of
Scalable parallel distance field construction for large-scale applications
Yu, Hongfeng; Xie, Jinrong; Ma, Kwan -Liu; Kolla, Hemanth; Chen, Jacqueline H.
Computing distance fields is fundamental to many scientific and engineering applications. Distance fields can be used to direct analysis and reduce data. In this paper, we present a highly scalable method for computing 3D distance fields on massively parallel distributed-memory machines. Anew distributed spatial data structure, named parallel distance tree, is introduced to manage the level sets of data and facilitate surface tracking overtime, resulting in significantly reduced computation and communication costs for calculating the distance to the surface of interest from any spatial locations. Our method supports several data types and distance metrics from real-world applications. We demonstrate itsmore » efficiency and scalability on state-of-the-art supercomputers using both large-scale volume datasets and surface models. We also demonstrate in-situ distance field computation on dynamic turbulent flame surfaces for a petascale combustion simulation. In conclusion, our work greatly extends the usability of distance fields for demanding applications.« less
Enhanced nearfield acoustic holography for larger distances of
U.S. Department of Energy (DOE) - all webpages (Extended Search)
reconstructions using fixed parameter Tikhonov regularization | Argonne National Laboratory Enhanced nearfield acoustic holography for larger distances of reconstructions using fixed parameter Tikhonov regularization Title Enhanced nearfield acoustic holography for larger distances of reconstructions using fixed parameter Tikhonov regularization Publication Type Journal Article Year of Publication 2016 Authors Chelliah, K, Raman, GG, Muehleisen, R Journal Journal of the Acoustical Society of
-meson decay constants from -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks
Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.
We calculate the
miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1
Xu, Zhengyu; Wang, Tao
Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.
MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1
Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang
Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.
A study of muon neutrino disappearance with the MINOS detectors and the NuMI neutrino beam
Marshall, John Stuart
This thesis presents the results of an analysis of vμ disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current vμ interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 1020 protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current vμ events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 ± 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as Δm$2\\atop{32}$ = 2.29$+0.14\\atop{-0.14}$ x 10-3 eV2 and sin2 2θ23
Validating time-distance helioseismology with realistic quiet-sun simulations
DeGrave, K.; Jackiewicz, J.; Rempel, M. E-mail: email@example.com
Linear time-distance helioseismic inversions are carried out for vector flow velocities using travel times measured from two ?100{sup 2} Mm{sup 2} � 20 Mm realistic magnetohydrodynamic quiet-Sun simulations of about 20 hr. The goal is to test current seismic methods on these state-of-the-art simulations. Using recent three-dimensional inversion schemes, we find that inverted horizontal flow maps correlate well with the simulations in the upper ?3 Mm of the domains for several filtering schemes, including phase-speed, ridge, and combined phase-speed and ridge measurements. In several cases, however, the velocity amplitudes from the inversions severely underestimate those of the simulations, possibly indicating nonlinearity of the forward problem. We also find that, while near-surface inversions of the vertical velocities are best using phase-speed filters, in almost all other example cases these flows are irretrievable due to noise, suggesting a need for statistical averaging to obtain better inferences.
miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4
Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang
Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.
Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity
Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others
Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.
Alaska North Slope Tundra Travel Model and Validation Study
Harry R. Bader; Jacynthe Guimond
The Alaska Department of Natural Resources (DNR), Division of Mining, Land, and Water manages cross-country travel, typically associated with hydrocarbon exploration and development, on Alaska's arctic North Slope. This project is intended to provide natural resource managers with objective, quantitative data to assist decision making regarding opening of the tundra to cross-country travel. DNR designed standardized, controlled field trials, with baseline data, to investigate the relationships present between winter exploration vehicle treatments and the independent variables of ground hardness, snow depth, and snow slab thickness, as they relate to the dependent variables of active layer depth, soil moisture, and photosynthetically active radiation (a proxy for plant disturbance). Changes in the dependent variables were used as indicators of tundra disturbance. Two main tundra community types were studied: Coastal Plain (wet graminoid/moist sedge shrub) and Foothills (tussock). DNR constructed four models to address physical soil properties: two models for each main community type, one predicting change in depth of active layer and a second predicting change in soil moisture. DNR also investigated the limited potential management utility in using soil temperature, the amount of photosynthetically active radiation (PAR) absorbed by plants, and changes in microphotography as tools for the identification of disturbance in the field. DNR operated under the assumption that changes in the abiotic factors of active layer depth and soil moisture drive alteration in tundra vegetation structure and composition. Statistically significant differences in depth of active layer, soil moisture at a 15 cm depth, soil temperature at a 15 cm depth, and the absorption of photosynthetically active radiation were found among treatment cells and among treatment types. The models were unable to thoroughly investigate the interacting role between snow depth and disturbance due to a lack
Station Footprint: Separation Distances, Storage Options, and Pre-Cooling
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
STATION FOOTPRINT SeparaDon Distances, Storage OpDons and Pre--- cooling Aaron Harris Sandia NaDonal Laboratory 20 March 2013 Sandia National Laboratories is a multi program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. . SeparaDon Distances Why do we have separaDon distances? * Hydrogen Release Hazards: Jet Fire or
Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2
Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga
Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor
Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression
Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua
Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.
miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway
Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie
Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.
miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression
Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.
Three-cell traveling wave superconducting test structure
Avrakhov, Pavel; Kanareykin, Alexei; /Euclid Techlabs, Solon; Kazakov, Sergey; Solyak, Nikolay; Wu, Genfa; Yakovlev, Vyacheslav P.; /Fermilab
Use of a superconducting traveling wave accelerating (STWA) structure with a small phase advance per cell rather than a standing wave structure may provide a significant increase of the accelerating gradient in the ILC linac. For the same surface electric and magnetic fields the STWA achieves an accelerating gradient 1.2 larger than TESLA-like standing wave cavities. The STWA allows also longer acceleration cavities, reducing the number of gaps between them. However, the STWA structure requires a SC feedback waveguide to return the few hundreds of MW of circulating RF power from the structure output to the structure input. A test single-cell cavity with feedback was designed, manufactured and successfully tested demonstrating the possibility of a proper processing to achieve a high accelerating gradient. These results open way to take the next step of the TW SC cavity development: to build and test a travelingwave three-cell cavity with a feedback waveguide. The latest results of the single-cell cavity tests are discussed as well as the design of the test 3-cell TW cavity.
Request for Travel Funds for Systems Radiation Biology Workshop
Barcellos-Hoff, Mary Helen
The 3rd International Systems Radiation Biology Workshop brought together the major European, US and Japanese research programs on radiation risk as well as selected experts representing systems biological approaches to discuss how the new methodologies could be best exploited for low dose research. A significant part of the workshop was devoted to discussions organised as breakout group sessions. To facilitate discussions number of participants was limited to 60 persons. To achieve the goals of this symposium in this international conference, support from DOE is vital. Hence, this proposal requested support in the amount of $15,000 to cover the travel expenses of international experts and radiation biology scientists from the United States. This supporting mechanism was clearly identified to the selected US participants as a conference support award from the DOE (See attached PDF). The workshop was an outstanding opportunity to strengthen interactions between leading experts in the emerging areas of radiation sciences, and will also provide opportunities for younger scientists to meet with experts and discuss their results. This workshop was designed to endorse active engagement in international collaboration. A major objective of this conference was to effectively communicate research results, in order to ensure that current thinking reflects sound science of radiation biology. Further, this international event addressed the use and success of scientific initiatives in radiation biology for policymakers, standard-setters, and the general public.
Property:Distance from Shore(m) | Open Energy Information
OpenEI (Open Energy Information) [EERE & EIA]
Shore(m) Jump to: navigation, search Property Name Distance from Shore(m) Property Type String Retrieved from "http:en.openei.orgwindex.php?titleProperty:DistancefromShore(m...
Long working-distance, incoherent light interference microscope...
Office of Scientific and Technical Information (OSTI)
Journal Article: Long working-distance, incoherent light interference microscope Citation ... OSTI Identifier: 973677 Report Number(s): SAND2005-3369J Journal ID: ISSN 0003-6935; ...
The solar neighborhood. XXXV. Distances to 1404 M dwarf systems...
Office of Scientific and Technical Information (OSTI)
solar neighborhood. XXXV. Distances to 1404 M dwarf systems within 25 PC in the southern sky Winters, Jennifer G.; Jao, Wei-Chun; Dieterich, Sergio B., E-mail:...
Improved Distances to Type Ia Supernovae withMulticolor Light...
Office of Scientific and Technical Information (OSTI)
We present an updated version of the Multicolor Light Curve Shape method to measure distances to type Ia supernovae (SN Ia), incorporating new procedures for K-correction and ...
Notice of Intent to Develop a Page Change to DOE O 551.1D, Official Foreign Travel
Directives, Delegations, and Other Requirements [Office of Management (MA)]
The requirement to surrender official passports is considered burdensome to travelers and will be removed as a requirement and replaced with a process that requires travelers be responsible for safeguarding their own official passports. In conjunction with this revision, administrative changes will be made to update the title of the Office of Travel Management.
Travel Patterns and Characteristics of Elderly Subpopulation in New York State
Hwang, Ho-Ling; Wilson, Daniel W.; Reuscher, Tim; Yang, Jianjiang; Taylor, Rob D.; Chin, Shih-Miao
With the increasing demographic shift towards a larger population of elderly (individuals 65 years and older), it is essential for policy makers and planners to have an understanding of transportation issues that affect the elderly. These issues include livability of the community, factors impacting travel behavior and mobility, transportation safety, etc. In this study, Oak Ridge National Laboratory was tasked by the New York State (NYS) Department of Transportation to conduct a detailed examination of travel behaviors, and identify patterns and trends of the elderly within NYS. The National Household Travel Survey (NHTS) was used as the primary data source to analyze subjects and address questions such as: Are there differences in traveler demographics between the elderly population and those of younger age groups who live in various NYS regions; e.g., New York City, other urban areas of NYS, or other parts of the country? How do they compare with the population at large? Are there any regional differences (e.g., urban versus rural)? Gender differences? Do any unique travel characteristics or patterns exist within the elderly group? In addition to analysis of NHTS data, roadway travel safety concerns associated with elderly travelers were also investigated in this study. Specifically, data on accidents involving the elderly (including drivers, passengers, and others) as captured in the Fatal Analysis Reporting System (FARS) database was analyzed to examine elderly driver and elderly pedestrian travel safety issues in NYS. The analyses of these data sets provide a greater understanding of the elderly within NYS and their associated transportation issues. Through this study, various key findings on elderly population size, household characteristics, and travel patterns were produced and are report herein this report.
A new Cepheid distance measurement and method for NGC 6822
Rich, Jeffrey A.; Persson, S. E.; Freedman, Wendy L.; Madore, Barry F.; Monson, Andrew J.; Scowcroft, Victoria; Seibert, Mark
We present a revised distance to the nearby galaxy NGC 6822 using a new multi-band fit to both previously published and new optical, near-, and mid-infrared data for Cepheid variables. The new data presented in this study include multi-epoch observations obtained in 3.6 μm and 4.5 μm with the Spitzer Space Telescope taken for the Carnegie Hubble Program. We also present new observations in J, H, and K{sub s} with FourStar on the Magellan Baade Telescope at Las Campanas Observatory. We determine mean magnitudes and present new period-luminosity relations in V, I, J, H, K{sub s} , Infrared Array Camera 3.6 μm, and 4.5 μm. In addition to using the multi-band distance moduli to calculate extinction and a true distance, we present a new method for determining an extinction-corrected distance modulus from multi-band data with varying sample sizes. We combine the distance moduli and extinction for individual stars to determine E(B – V) = 0.35 ± 0.04 and a true distance modulus μ {sub o} = 23.38 ± 0.02{sub stat} ± 0.04{sub sys}.
Secretaries Chu and Locke to Travel to China Next Week | Department of
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Energy Locke to Travel to China Next Week Secretaries Chu and Locke to Travel to China Next Week July 6, 2009 - 12:00am Addthis WASHINGTON -- Energy Secretary Steven Chu and Commerce Secretary Gary Locke will travel to China from July 14 to 17. The two secretaries will highlight the tremendous potential for mutually beneficial relationships in the clean energy sector. "Clean energy will drive the economy of the future, both in the United States and around the world," Chu said.
Secretary Chu To Travel to China and Japan | Department of Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
To Travel to China and Japan Secretary Chu To Travel to China and Japan November 5, 2010 - 12:00am Addthis Washington, D.C. -U.S. Energy Secretary Steven Chu will travel to China and Japan November 14 - 19 to meet with government officials, business leaders and others to discuss the Department's ongoing clean energy and scientific collaboration with both countries. More information about the trip is as follows: Shanghai, China On Sunday, November 14, Secretary Chu will tour clean energy
Secretary Chu will Travel to China to Highlight Clean Energy Partnerships |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy will Travel to China to Highlight Clean Energy Partnerships Secretary Chu will Travel to China to Highlight Clean Energy Partnerships April 28, 2010 - 12:00am Addthis WASHINGTON - U.S. Energy Secretary Steven Chu will travel to China from May 24th to 28th to highlight the benefit of U.S.-China partnerships and cooperation in the clean energy sector. He will visit with government officials, academia and members of the private sector in both Beijing and Shanghai to learn
Fact #566: April 13, 2009 Vehicle Travel and the Price of Gasoline |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy 6: April 13, 2009 Vehicle Travel and the Price of Gasoline Fact #566: April 13, 2009 Vehicle Travel and the Price of Gasoline The price of gasoline is one factor that can have an effect on the number of highway vehicle miles traveled (VMT). The graph below shows a three-month moving average of the percentage change of monthly data from one year to the next (i.e., February 2001 data were compared with February 2000 data). In 2008, when gasoline prices were 20-30% higher,
Fact #616: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
| Department of Energy 6: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose Fact #616: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose In 2009, getting to and from work accounted for about 27% of household vehicle-miles of travel (VMT). Work-related business was 8.4% of VMT in 2001, but declined to 6.7% in 2009, possibly due to advancements in computing technology making it possible for more business to be handled electronically. VMT for shopping was almost
Fact #903: December 14, 2015 Vehicle Miles of Travel is up in 2015 -
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Dataset | Department of Energy 903: December 14, 2015 Vehicle Miles of Travel is up in 2015 - Dataset Fact #903: December 14, 2015 Vehicle Miles of Travel is up in 2015 - Dataset Excel file and dataset for Vehicle Miles of Travel is up in 2015 fotw#903_web.xlsx (17.31 KB) More Documents & Publications Project Reports for Salish and Kootenai Tribes, Confederated Tribes of the Flathead Reservation: S&K Holding Company - 2004 Project 2015 GTO Peer Review Fact #926: May 23, 2016
Fact #945: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy 5: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs Fact #945: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs SUBSCRIBE to the Fact of the Week From 1992 through the end of 2007, U.S. vehicle miles of travel (VMT) rose at a fairly brisk and steady pace to exceed three trillion miles per year (measured in 12-month running totals). During the Great Recession VMT began a downward trend that leveled off just below three trillion miles until the
Fact #842: October 13, 2014 Vehicles and Vehicle Travel Trends have Changed
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Since 2008 - Dataset | Department of Energy 2: October 13, 2014 Vehicles and Vehicle Travel Trends have Changed Since 2008 - Dataset Fact #842: October 13, 2014 Vehicles and Vehicle Travel Trends have Changed Since 2008 - Dataset Excel file with dataset for Fact #842: Vehicles and Vehicle Travel Trends have Changed Since 2008 fotw#842_web.xlsx (27.66 KB) More Documents & Publications Residential Lighting Usage Estimate Tool, v1.0 Residential Lighting Usage Estimate Tool, v1.0, MacOS
Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Price of Gasoline - Dataset | Department of Energy 0 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline - Dataset Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline - Dataset Excel file and dataset for Relationship of Vehicle Miles of Travel and the Price of Gasoline fotw#860_web.xlsx (30.54 KB) More Documents & Publications Fact #906: January 4, 2016 VMT and the Price of Gasoline Typically Move in Opposition -
Fact #945: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs -
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Dataset | Department of Energy 5: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs - Dataset Fact #945: October 3, 2016 Vehicle Miles of Travel Has Reached New Highs - Dataset Excel file and dataset for Vehicle Miles of Travel Has Reached New Highs fotw#945_web.xlsx (26.4 KB) More Documents & Publications Fact #890: September 14, 2015 Gasoline Prices Are Affected by Changes in Refinery Output - Dataset Residential Lighting Usage Estimate Tool, v1.0 Residential Lighting Usage
Acquisition Guide Chapter 42.2- Documentation and Approval of Federally Funded International Travel
The subject guide chapter provides guidance to DOE Contracting Officers, Contracting Officer Representatives, and Program Officials on documentation and approval of federally funded international travel by Federal contractors and subcontractors. Contracting Officers, Contracting Officer Representatives or Program Officials responsible for reviewing and approving for payment Contractor invoices that include travel expenses must ensure that when a foreign air carrier is used a certification is provided with the invoice in accordance with §301-10.142 of the FTR. Reimbursement for travel expenses from a foreign air carrier fare may be denied if appropriate certification is not provided.
Traveling wave device for combining or splitting symmetric and asymmetric waves
Möbius, Arnold; Ives, Robert Lawrence
A traveling wave device for the combining or splitting of symmetric and asymmetric traveling wave energy includes a feed waveguide for traveling wave energy, the feed waveguide having an input port and a launching port, a reflector for coupling wave energy between the feed waveguide and a final waveguide for the collection and transport of wave energy to or from the reflector. The power combiner has a launching port for symmetrical waves which includes a cylindrical section coaxial to the feed waveguide, and a launching port for asymmetric waves which includes a sawtooth rotated about a central axis.
Energy Secretary Moniz to Travel to Los Angeles for Events Focusing on
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Clean Energy Innovation and Climate Change | Department of Energy to Travel to Los Angeles for Events Focusing on Clean Energy Innovation and Climate Change Energy Secretary Moniz to Travel to Los Angeles for Events Focusing on Clean Energy Innovation and Climate Change October 3, 2016 - 11:42am Addthis News Media Contact (202) 586-4940 firstname.lastname@example.com WASHINGTON - On Monday, October 3, 2016, U.S. Secretary of Energy Ernest Moniz will travel to Los Angeles for three events focusing on the
Search for Long-Lived Particles inCollisions
Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Kerth, L. T.; Kolomensky, Yu. G.; Lee, M. J.; Lynch, G.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Dey, B.; Gary, J. W.; Long, O.; Campagnari, C.; Franco Sevilla, M.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Bernard, D.; Verderi, M.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Piemontese, L.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Lo Vetere, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Bhuyan, B.; Prasad, V.; Adametz, A.; Uwer, U.; Lacker, H. M.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Sciolla, G.; Cheaib, R.; Patel, P. M.; Robertson, S. H.; Neri, N.; Palombo, F.; Cremaldi, L.; Godang, R.; Sonnek, P.; Summers, D. J.; Simard, M.; Taras, P.; De Nardo, G.; Onorato, G.; Sciacca, C.; Martinelli, M.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Feltresi, E.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Pacetti, S.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Cervelli, A.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Perez, A.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Hess, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Bard, D. J.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Lindemann, D.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Wulsin, H. W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Wray, B. C.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P.; Albert, J.; Banerjee, Sw.; Beaulieu, A.; Bernlochner, F. U.; Choi, H. H. F.; King, G. J.; Kowalewski, R.; Lewczuk, M. J.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Band, H. R.; Dasu, S.; Pan, Y.; Prepost, R.; Wu, S. L.
We present a search for a neutral, long-lived particle L that is produced in e+e- collisions and decays at a significant distance from the e+e- interaction point into various flavor combinations of two oppositely charged tracks. The analysis uses an e+e- data sample with a luminosity of 489.1 fb-1 collected by the BABAR detector at the γ (4S), γ (3S), and γ (2S) resonances and just below the γ (4S). Fitting the two-track mass distribution in search of a signal peak, we do not observe a significant signal, and set 90% confidence level upper limits on the product of the L production cross section, branching fraction, and reconstruction efficiency for six possible two-body L decay modes as a function of the L mass. The efficiency is given for each final state as a function of the mass, lifetime, and transverse momentum of the candidate, allowing application of the upper limits to any production model. In addition, upper limits are provided on the branching fraction B(B→XsL), where Xs is a strange hadronic system.
MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression
Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan
Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the
MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ
Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui
Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.
Statement on U.S. Secretary of Energy Ernest Moniz's Travel to...
Energy.gov [DOE] (indexed site)
Energy Ernest Moniz will travel to Istanbul, Turkey November 20 to 23 and give opening remarks at the 5th Atlantic Council Energy Summit. Secretary Moniz will also attend the ...
Fact #584: August 17, 2009 The Price of Gasoline and Vehicle Travel: How Do They Relate?
Office of Energy Efficiency and Renewable Energy (EERE)
The price of gasoline is one factor that can have an effect on the number of highway vehicle miles traveled (VMT). The graph below shows a three-month moving average of the percentage change of...
Rebound 2007: Analysis of U.S. Light-Duty Vehicle Travel Statistics
Greene, David L
U.S. national time series data on vehicle travel by passenger cars and light trucks covering the period 1966 2007 are used to test for the existence, size and stability of the rebound effect for motor vehicle fuel efficiency on vehicle travel. The data show a statistically significant effect of gasoline price on vehicle travel but do not support the existence of a direct impact of fuel efficiency on vehicle travel. Additional tests indicate that fuel price effects have not been constant over time, although the hypothesis of symmetry with respect to price increases and decreases is not rejected. Small and Van Dender (2007) model of a declining rebound effect with income is tested and similar results are obtained.
Fact #903: December 14, 2015 Vehicle Miles of Travel is up in...
Energy.gov [DOE] (indexed site)
Vehicle Miles of Travel is up in 2015 fotw903web.xlsx (17.31 KB) More Documents & Publications Project Reports for Salish and Kootenai Tribes, Confederated Tribes of the Flathead ...
Fact #698: October 24, 2011 Changes in the Federal Highway Administration Vehicle Travel Data
With the April release of Table VM-1 from Highway Statistics 2009 came several changes to the availability of data on vehicle miles of travel (VMT). From 1966 to 2008, the Federal Highway...
The NuMI proton beam at Fermilab successes and challenges
Childress, S.; /Fermilab
The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.
DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI
Office of Energy Efficiency and Renewable Energy (EERE)
Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...
Secretary Chu and Energy Department Officials to Travel Across America to
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Discuss the Obama Administration's Commitment to Energy Innovation and Manufacturing | Department of Energy Travel Across America to Discuss the Obama Administration's Commitment to Energy Innovation and Manufacturing Secretary Chu and Energy Department Officials to Travel Across America to Discuss the Obama Administration's Commitment to Energy Innovation and Manufacturing January 24, 2012 - 3:47pm Addthis Washington D.C. - This week, Energy Secretary Steven Chu, Deputy Secretary Daniel
Secretary Chu to Travel to India and China to Promote Clean Energy
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Partnerships | Department of Energy India and China to Promote Clean Energy Partnerships Secretary Chu to Travel to India and China to Promote Clean Energy Partnerships November 10, 2009 - 12:00am Addthis Washington, DC - The Department of Energy announced today that Energy Secretary Steven Chu will travel to India and China from Thursday, November 12 to Wednesday, November 18 as part of the Department's efforts to advance opportunities for international clean energy cooperation. During the
NNSA Launches Second Travel Blog to Feature Administrator's Work at Next
National Nuclear Security Administration (NNSA)
Generation Safeguards Meeting in Japan | National Nuclear Security Administration | (NNSA) Launches Second Travel Blog to Feature Administrator's Work at Next Generation Safeguards Meeting in Japan October 26, 2009 WASHINGTON, D.C. - The National Nuclear Security Administration (NNSA) today launched its second travel blog, allowing online visitors to follow NNSA Administrator Thomas D'Agostino and receive updates from the second international meeting on Next Generation Safeguards in
Secretary Bodman To Travel to Vienna, Austria for Second GNEP Ministerial
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
and IAEA General Conference | Department of Energy Bodman To Travel to Vienna, Austria for Second GNEP Ministerial and IAEA General Conference Secretary Bodman To Travel to Vienna, Austria for Second GNEP Ministerial and IAEA General Conference A letter issued by the Department of Energy's Office of Public Affairs detailling the mission behind the U.S. Secretary of Energy Samuel W. Bodman's trip to Vienna, Austria, to chair the second Global Nuclear Energy Partnership (GNEP) Ministerial on
Clean Energy Investment Center Travels to India on Mission to Harness
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Public-Private Partnerships | Department of Energy Travels to India on Mission to Harness Public-Private Partnerships Clean Energy Investment Center Travels to India on Mission to Harness Public-Private Partnerships August 26, 2016 - 3:19pm Addthis Announcement from the Clean Energy Investment Center, August 26, 2016. The Clean Energy Investment Center (CEIC) team, led by Director Sanjiv Malhotra is currently en route to New Delhi, India to speak at and facilitate a roundtable discussion
Tuning gain and bandwidth of traveling wave tubes using metamaterial beam-wave interaction structures
Lipton, Robert Polizzi, Anthony
We employ metamaterial beam-wave interaction structures for tuning the gain and bandwidth of short traveling wave tubes. The interaction structures are made from metal rings of uniform cross section, which are periodically deployed along the length of the traveling wave tube. The aspect ratio of the ring cross sections is adjusted to control both gain and bandwidth. The frequency of operation is controlled by the filling fraction of the ring cross section with respect to the size of the period cell.
NNSA Administrator D'Agostino's 2009 IAEA Travel Blog | National Nuclear
National Nuclear Security Administration (NNSA)
Security Administration | (NNSA) Administrator D'Agostino's 2009 IAEA Travel Blog Follow the 53rd General Conference in Vienna, Austria Follow the 53rd General Conference in Vienna, Austria NNSA Administrator Thomas D'Agostino and Secretary of Energy Steven Chu attended the 53rd General Conference of the International Atomic Energy Agency in Vienna, Austria. This page documents the Administrator's travels as he promoted NNSA programs and presented President Barack Obama's unprecedented
MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin
Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui
MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.
miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer
Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang
Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.
-parameter distribution at including power corrections
Hoang, André H.; Kolodrubetz, Daniel W.; Mateu, Vicent; Stewart, Iain W.
We compute the e⁺e⁻ C-parameter distribution using the soft-collinear effective theory with a resummation to next-to-next-to-next-to-leading-log prime accuracy of the most singular partonic terms. This includes the known fixed-order QCD results up to O(α3s), a numerical determination of the two-loop nonlogarithmic term of the soft function, and all logarithmic terms in the jet and soft functions up to three loops. Our result holds for C in the peak, tail, and far tail regions. Additionally, we treat hadronization effects using a field theoretic nonperturbative soft function, with moments Ωn. To eliminate an O(ΛQCD) renormalon ambiguity in the soft function, we switch from the MS¯ to a short distance "Rgap" scheme to define the leading power correction parameter Ω1. We show how to simultaneously account for running effects in Ω1 due to renormalon subtractions and hadron-mass effects, enabling power correction universality between C-parameter and thrust to be tested in our setup. We discuss in detail the impact of resummation and renormalon subtractions on the convergence. In the relevant fit region for αs(mZ) and Ω1, the perturbative uncertainty in our cross section is ≅ 2.5% at Q=mZ.
Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation
Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang
Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.
PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling
Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi
Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.
Development of the table of initial isolation distances and protective action distances for the 2004 emergency response guidebook.
Brown, D. F.; Freeman, W. A.; Carhart, R. A.; Krumpolc, M.; Decision and Information Sciences; Univ. of Illinois at Chicago
This report provides technical documentation for values in the Table of Initial Isolation and Protective Action Distances (PADs) in the 2004 Emergency Response Guidebook (ERG2004). The objective for choosing the PADs specified in the ERG2004 is to balance the need to adequately protect the public from exposure to potentially harmful substances against the risks and expenses that could result from overreacting to a spill. To quantify this balance, a statistical approach is adopted, whereby the best available information is used to conduct an accident scenario analysis and develop a set of up to 1,000,000 hypothetical incidents. The set accounts for differences in containers types, incident types, accident severity (i.e., amounts released), locations, times of day, times of year, and meteorological conditions. Each scenario is analyzed using detailed emission rate and atmospheric dispersion models to calculate the downwind chemical concentrations from which a 'safe distance' is determined. The safe distance is defined as the distance downwind from the source at which the chemical concentration falls below health protection criteria. The American Industrial Hygiene Association's Emergency Response Planning Guideline Level 2 (ERPG-2) or equivalent is the health criteria used. The statistical sample of safe distance values for all incidents considered in the analysis are separated into four categories: small spill/daytime release, small spill/nighttime release, large spill/daytime release, and large spill/nighttime release. The 90th-percentile safe distance values for each of these groups became the PADs that appear in the ERG2004.
Separated response functions in exclusive, forward electroproduction on deuterium
Huber, G. M.; Blok, H. P.; Butuceanu, C.; Gaskell, D.; Horn, T.; Mack, D. J.; Abbott, D.; Aniol, K.; Anklin, H.; Armstrong, C.; Arrington, J.; Assamagan, K.; Avery, S.; Baker, O. K.; Barrett, B.; Beise, E. J.; Bochna, C.; Boeglin, W.; Brash, E. J.; Breuer, H.; Chang, C. C.; Chant, N.; Christy, M. E.; Dunne, J.; Eden, T.; Ent, R.; Fenker, H.; Gibson, E. F.; Gilman, R.; Gustafsson, K.; Hinton, W.; Holt, R. J.; Jackson, H.; Jin, S.; Jones, M. K.; Keppel, C. E.; Kim, P. H.; Kim, W.; King, P. M.; Klein, A.; Koltenuk, D.; Kovaltchouk, V.; Liang, M.; Liu, J.; Lolos, G. J.; Lung, A.; Margaziotis, D. J.; Markowitz, P.; Matsumura, A.; McKee, D.; Meekins, D.; Mitchell, J.; Miyoshi, T.; Mkrtchyan, H.; Mueller, B.; Niculescu, G.; Niculescu, I.; Okayasu, Y.; Pentchev, L.; Perdrisat, C.; Pitz, D.; Potterveld, D.; Punjabi, V.; Qin, L. M.; Reimer, P. E.; Reinhold, J.; Roche, J.; Roos, P. G.; Sarty, A.; Shin, I. K.; Smith, G. R.; Stepanyan, S.; Tang, L. G.; Tadevosyan, V.; Tvaskis, V.; van der Meer, R. L. J.; Vansyoc, K.; Van Westrum, D.; Vidakovic, S.; Volmer, J.; Vulcan, W.; Warren, G.; Wood, S. A.; Xu, C.; Yan, C.; Zhao, W. -X.; Zheng, X.; Zihlmann, B.
Background: Measurements of forward exclusive meson production at different squared four-momenta of the exchanged virtual photon, Q2, and at different four-momentum transfer, t, can be used to probe QCD's transition from meson-nucleon degrees of freedom at long distances to quark-gluon degrees of freedom at short scales. Ratios of separated response functions in ?? and ?? electroproduction are particularly informative. Ratio for transverse photons may allow this transition to be more easily observed, while the ratio for longitudinal photons provides a crucial verification of the assumed pole dominance, needed for reliable extraction of the pion form factor from electroproduction data. Method: Data were acquired with 2.6-5.2 GeV electron beams and the HMS+SOS spectrometers in Jefferson Lab Hall C, at central Q2 values of 0.6, 1.0, 1.6 GeV2 at W=1.95 GeV, and Q2=2.45 GeV2 at W=2.22 GeV. There was significant coverage in ? And ?, which allowed separation of ?L,T,LT,TT. Results: ?L shows a clear signature of the pion pole, with a sharp rise at small -t. In contrast, ?T is much flatter versus t. The longitudinal/transverse ratios evolve with Q2 and t, and at the highest Q2=2.45 GeV2 show a slight enhancement for ?? Production compared to ??. The ??/??+ ratio for transverse photons exhibits only a small Q2-dependence, following a nearly universal curve with t, with a steep transition to a value of about 0.25, consistent with s-channel quark knockout. The ?TT/?T ratio also drops rapidly with Q2, qualitatively consistent with s-channel helicity conservation. The ??/?? ratio for longitudinal photons indicates a small isoscalar contamination at W=1.95 GeV, consistent with what was observed in our earlier determination of the pion form factor at these kinematics.
Modelling long-distance seed dispersal in heterogeneous landscapes.
Levey, Douglas, J.; Tewlsbury, Joshua, J.; Bolker, Benjamin, M.
1. Long-distance seed dispersal is difficult to measure, yet key to understanding plant population dynamics and community composition. 2. We used a spatially explicit model to predict the distribution of seeds dispersed long distances by birds into habitat patches of different shapes. All patches were the same type of habitat and size, but varied in shape. They occurred in eight experimental landscapes, each with five patches of four different shapes, 150 m apart in a matrix of mature forest. The model was parameterized with smallscale movement data collected from field observations of birds. In a previous study we validated the model by testing its predictions against observed patterns of seed dispersal in real landscapes with the same types and spatial configuration of patches as in the model. 3. Here we apply the model more broadly, examining how patch shape influences the probability of seed deposition by birds into patches, how dispersal kernels (distributions of dispersal distances) vary with patch shape and starting location, and how movement of seeds between patches is affected by patch shape. 4. The model predicts that patches with corridors or other narrow extensions receive higher numbers of seeds than patches without corridors or extensions. This pattern is explained by edgefollowing behaviour of birds. Dispersal distances are generally shorter in heterogeneous landscapes (containing patchy habitat) than in homogeneous landscapes, suggesting that patches divert the movement of seed dispersers, �holding� them long enough to increase the probability of seed defecation in the patches. Dispersal kernels for seeds in homogeneous landscapes were smooth, whereas those in heterogenous landscapes were irregular. In both cases, long-distance (> 150 m) dispersal was surprisingly common, usually comprising approximately 50% of all dispersal events. 5. Synthesis . Landscape heterogeneity has a large influence on patterns of long-distance seed dispersal. Our results
Quantifying groundwater travel time near managed recharge operations using 35S as an intrinsic tracer
Urióstegui, Stephanie H.; Bibby, Richard K.; Esser, Bradley K.; Clark, Jordan F.
By identifying groundwater retention times near managed aquifer recharge (MAR) facilities is a high priority for managing water quality, especially for operations that incorporate recycled wastewater. In order to protect public health, California guidelines for Groundwater Replenishment Reuse Projects require a minimum 2–6 month subsurface retention time for recycled water depending on the level of disinfection, which highlights the importance of quantifying groundwater travel times on short time scales. This study developed and evaluated a new intrinsic tracer method using the naturally occurring radioisotope sulfur-35 (35S). The 87.5 day half-life of 35S is ideal for investigating groundwater travel times onmore » the <1 year timescale of interest to MAR managers. Natural concentrations of 35S found in water as dissolved sulfate (35SO4) were measured in source waters and groundwater at the Rio Hondo Spreading Grounds in Los Angeles County, CA, and Orange County Groundwater Recharge Facilities in Orange County, CA. 35SO4 travel times are comparable to travel times determined by well-established deliberate tracer studies. The study also revealed that 35SO4 in MAR source water can vary seasonally and therefore careful characterization of 35SO4 is needed to accurately quantify groundwater travel time. But, more data is needed to fully assess whether or not this tracer could become a valuable tool for managers.« less
Relationships between weekly walking distance and adiposity in27,596 women are nonlinear with respect to both distance andadiposity
Williams, Paul T.
The cross-sectional relationships of weekly walking distance to BMI, body circumferences, and bra cup sizes are reported for 27,596 women. The percent reductions between walking 40-50 km/wk and < 10km/wk were greatest for BMI, substantial for waist circumference and cupsize, and least for hip and chest circumferences. The relationships between distance and adiposity were nonlinear with respect to both the independent (quadratic function of distance) and dependent variables(slope and curvilinearity depending upon the percentile of BMI, circumference, or cup size). The slope relating adiposity to km/wk were greatest (most negative) in overweight sedentary women and least in lean active women. For example, compared to women averaging 10 km/wk, the slope of BMI versus km/wk was 43 percent less at 25 km/wk and 87 percent less at 40 km/wk in overweight women (95th BMI percentile), but negligible at all distances in lean women (5th BMI percentile). The greater estimated decrease in BMI per km/wk in walkers than runners was largely accounted for (over 75 percent) by the walkers greater adiposity. Thus classical representations of the relationship between adiposity and moderate physical activity are inadequate for either statistical analyses or descriptive purposes. The clinical implications of these results and their statistical ramifications are discussed.
RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...
Office of Scientific and Technical Information (OSTI)
in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...
Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation
Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the
Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab
Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.
In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.
Distance Restraints from Crosslinking Mass Spectrometry: Mining a Molecular Dynamics Simulation Database to Evaluate Lysine-Lysine Distances
Merkley, Eric D.; Rysavy, Steven; Kahraman, Abdullah; Hafen, Ryan P.; Daggett, Valerie; Adkins, Joshua N.
Integrative structural biology models the structures of protein complexes that are intractable by classical structural methods (because of extreme size, dynamics, or heterogeneity) by combining computational structural modeling with data from experimental methods. One such method is chemical cross-linking mass spectrometry (XL-MS), in which cross-linked peptides, derived from a covalently cross-linked protein complex and identified by liquid chromatography-mass spectrometry, pinpoint protein residues close in three-dimensional space. The commonly used lysine-reactive N-hydroxysuccinimide ester reagents disuccinimidylsuberate (DSS) and bis(sulfosuccinimidyl)suberate (BS3) have a linker arm that is 11.4 Å long when fully extended. However, XL-MS studies on proteins of known structure frequently report cross-links that exceed this distance. Typically, a tolerance of ~3 Å is added to the theoretical maximum to account for this observation, with little justification for the value chosen. We used the Dynameomics database, a repository of high-quality molecular dynamics simulations of 807 proteins representative of all protein folds, to investigate the change in lysine-lysine distances resulting from native-state dynamics on the time-scale of tens of nanoseconds. We conclude that observed cross-links are consistent with a protein structure if the distance between cross-linked lysine Nζ atoms is less than the cross-linker length plus 11.3 Å. For DSS or BS3, this corresponds to a Cα to Cα distance of 30.4 Å. This analysis provides a theoretical basis for the widespread practice of adding a tolerance to the crosslinker length when comparing XL-MS results to structures, and indicates the appropriate values of an XLMS derived distance constraint to use in structural modeling.
Measurement of Pi-K Ratios from the NuMI Target
Seun, Sin Man
Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-/π+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.
miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo
Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup
Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.
Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro
Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping
Highlight: �MiR-21 plays a significant role in 5-FU resistance. �This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. �Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.
Distance-redshift relations in an anisotropic cosmological model
Menezes, R. S. Jr.; Pigozzo, C.; Carneiro, S. E-mail: email@example.com
In this paper we study an anisotropic model generated from a particular Bianchi type-III metric, which is a generalization of G�del's metric and an exact solution of Einstein's field equations. We analyse type Ia supernova data, namely the SDSS sample calibrated with the MLCS2k2 fitter, and we verify in which ranges of distances and redshifts the anisotropy could be observed. We also consider, in a joint analysis, the position of the first peak in the CMB anisotropy spectrum, as well as current observational constraints on the Hubble constant. We conclude that a small anisotropy is permitted by the data, and that more accurate measurements of supernova distances above z = 2 might indicate the existence of such anisotropy in the universe.
Roberts, Lewis C.; Gies, Douglas R.; Parks, J. Robert; Grundstrom, Erika D.; McSwain, M. Virginia; Berger, David H.; Mason, Brian D.; Ten Brummelaar, Theo A.; Turner, Nils H. E-mail: email@example.com E-mail: email@example.com E-mail: firstname.lastname@example.com E-mail: email@example.com
The young open cluster Collinder 419 surrounds the massive O star, HD 193322, that is itself a remarkable multiple star system containing at least four components. Here we present a discussion of the cluster distance based upon new spectral classifications of the brighter members, UBV photometry, and an analysis of astrometric and photometric data from the third U. S. Naval Observatory CCD Astrograph Catalog and Two Micron All Sky Survey Catalog. We determine an average cluster reddening of E(B - V) = 0.37 {+-} 0.05 mag and a cluster distance of 741 {+-} 36 pc. The cluster probably contains some very young stars that may include a reddened M3 III star, IRAS 20161+4035.
Scanning optical microscope with long working distance objective
Cloutier, Sylvain G.
A scanning optical microscope, including: a light source to generate a beam of probe light; collimation optics to substantially collimate the probe beam; a probe-result beamsplitter; a long working-distance, infinity-corrected objective; scanning means to scan a beam spot of the focused probe beam on or within a sample; relay optics; and a detector. The collimation optics are disposed in the probe beam. The probe-result beamsplitter is arranged in the optical paths of the probe beam and the resultant light from the sample. The beamsplitter reflects the probe beam into the objective and transmits resultant light. The long working-distance, infinity-corrected objective is also arranged in the optical paths of the probe beam and the resultant light. It focuses the reflected probe beam onto the sample, and collects and substantially collimates the resultant light. The relay optics are arranged to relay the transmitted resultant light from the beamsplitter to the detector.
Electrical probe diagnostics for the laminar flame quenching distance
Karrer, Maxime; Makarov, Maxime; Bellenoue, Marc; Labuda, Sergei; Sotton, Julien
A simplified theory, previously developed for the general case of weakly ionized gas flow, is used to predict electrical probe response when the flame is quenched on the probe surface. This theory is based on the planar model of space charge sheaths around the measuring electrode. For the flame quenching case, by assuming that the sheath thickness is comparable with the thermal boundary layer thickness, probe current can be related to flame quenching distance. The theoretical assumptions made to obtain the analytical formulation of probe current were experimentally proved by using direct visualization and high-frequency PIV. The direct visualization method was also used to validate the results of flame quenching distance values obtained with electrical probe. The electrical probe diagnostics have been verified for both head-on and sidewall flame quenching regimes and for stoichiometric methane/air and propane/air mixtures in a pressure range of 0.05-0.6 MPa. (author)
distance_webinar_2013_03_05.wmv | Department of Energy
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distance_webinar_2013_03_05.wmv distance_webinar_2013_03_05.wmv distance_webinar_2013_03_05.wmv distance_webinar_2013_03_05.wmv (15.93 MB) More Documents & Publications Asset Score API Webinar June 14, 2013 Commercial Building Energy Asset Score 2013 Pilot Commercial Building Energy Asset Score 2013 Pilot
GE, NASA Work to Relaunch Supersonic Air Travel | GE Global Research
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Supporting NASA's efforts to Relaunch Commercial Supersonic Air Travel Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Tumblr (Opens in new window) GE Supporting NASA's efforts to Relaunch Commercial Supersonic Air Travel Awarded 2- year $599,000 program to reduce engine noise during takeoffs and landings NISKAYUNA, NY - JUNE 10, 2015 - Scientists
Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the
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Price of Gasoline | Department of Energy 0 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline The prices of gasoline and diesel fuel affect the transportation sector in many ways. For example, fuel prices can impact the number of miles driven and affect the choices consumers make when purchasing vehicles. The graph below shows a three-month moving average of the
Visa Document Guidelines Required for Travel Reimbursement for Foreign National Visitors
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Visa Document Guidelines Required for Travel Reimbursement for Foreign National Visitors JLab is a national laboratory supported by the U.S. Department of Energy (DOE) and, as such, we must follow the regulations of the DOE and the U.S. Citizenship and Immigration Services (USCIS) relating to reimbursement of travel expenses. For visitors who are not U.S. citizens these include a number of requirements that are stringent and, at the same, time not so obvious. Please read this page carefully and
Cut Gas Costs This Holiday Traveling Season with Three Easy Tips |
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Department of Energy Cut Gas Costs This Holiday Traveling Season with Three Easy Tips Cut Gas Costs This Holiday Traveling Season with Three Easy Tips November 26, 2013 - 9:23am Addthis Turning off your engine while waiting in the parking lot is a great way to save money on gas. | Photo courtesy of Kristy Keel-Blackmon, NREL/21196. Turning off your engine while waiting in the parking lot is a great way to save money on gas. | Photo courtesy of Kristy Keel-Blackmon, NREL/21196. Jason
Qing, Gao; Wang, Wei; Liu, Ji-Feng; Yoachim, Peter
We present the detection of Cepheids in the barred spiral galaxy NGC 1313, using the Wide Field and Planetary Camera 2 on the Hubble Space Telescope. Twenty B(F450W) and V(F555W) epochs of observations spanning over three weeks were obtained, on which the profile-fitting photometry of all stars in the monitored field was performed using the package HSTphot. A sample of 26 variable stars have been identified to be Cepheids, with periods between 3 and 14 days. Based on the derived period-luminosity relations in B- and V-bands, we obtain an extinction-corrected distance modulus of ?{sub NGC} {sub 1313} = 28.32 � 0.08 (random) � 0.06 (systematic), employing the Large Magellanic Cloud as the distance zero point calibrator. The above moduli correspond to a distance of 4.61�� 0.17 (random) �0.13 (systematic) Mpc, consistent with previous measurements reported in the literature within uncertainties. In addition, the reddening to NGC 1313 is found to be small.
miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma
Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang
MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.
RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer
Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong
MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.
MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma
Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua
Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.
MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1
Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan
Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.
Estimating Reaction Rate Coefficients Within a Travel-Time Modeling Framework
Gong, R; Lu, C; Luo, Jian; Wu, Wei-min; Cheng, H.; Criddle, Craig; Kitanidis, Peter K.; Gu, Baohua; Watson, David B; Jardine, Philip M; Brooks, Scott C
A generalized, efficient, and practical approach based on the travel-time modeling framework is developed to estimate in situ reaction rate coefficients for groundwater remediation in heterogeneous aquifers. The required information for this approach can be obtained by conducting tracer tests with injection of a mixture of conservative and reactive tracers and measurements of both breakthrough curves (BTCs). The conservative BTC is used to infer the travel-time distribution from the injection point to the observation point. For advection-dominant reactive transport with well-mixed reactive species and a constant travel-time distribution, the reactive BTC is obtained by integrating the solutions to advective-reactive transport over the entire travel-time distribution, and then is used in optimization to determine the in situ reaction rate coefficients. By directly working on the conservative and reactive BTCs, this approach avoids costly aquifer characterization and improves the estimation for transport in heterogeneous aquifers which may not be sufficiently described by traditional mechanistic transport models with constant transport parameters. Simplified schemes are proposed for reactive transport with zero-, first-, nth-order, and Michaelis-Menten reactions. The proposed approach is validated by a reactive transport case in a two-dimensional synthetic heterogeneous aquifer and a field-scale bioremediation experiment conducted at Oak Ridge, Tennessee. The field application indicates that ethanol degradation for U(VI)-bioremediation is better approximated by zero-order reaction kinetics than first-order reaction kinetics.
Microsoft Word - gra-ugs-program-travel-regs-tr9003.doc
U.S. Department of Energy (DOE) - all webpages (Extended Search)
No: CFO-TR9003 Revision: 2 Issued: 1/27/14 Effective Date: 1/27/14 Required Review Date: 1/27/16 LANL CFO-TR9003 1 of 7 GRA and UGS Program Travel Table o f C ontents 1.0 Purpose ........................................................................................................................................ 2 2.0 Authority and Applicability ............................................................................................................ 2 2.1 Authority
DOE Honors WIPP Representative for Cutting Travel Costs, Greenhouse Gas Emissions
WASHINGTON, D.C. – A representative of the Waste Isolation Pilot Plant (WIPP) near Carlsbad, N.M., on Tuesday received the Secretary of Energy's Appreciation Award for her efforts to improve sustainability and reduce travel costs and the number of fleet vehicles.
Traveling wave solutions in a chain of periodically forced coupled nonlinear oscillators
Duanmu, M.; Whitaker, N.; Kevrekidis, P. G.; Vainchtein, A.; Rubin, J. E.
Artificial perceptions of light called phosphenes were motivated by earlier studies. We analyze traveling wave solutions in a chain of periodically forced coupled nonlinear oscillators modeling this phenomenon. We examine the discrete model problem in its co-traveling frame and systematically obtain the corresponding traveling waves in one spatial dimension. Direct numerical simulations as well as linear stability analysis are employed to reveal the parameter regions where the traveling waves are stable, and these waves are, in turn, connected to the standing waves analyzed in earlier work. We also consider a two-dimensional extension of the model and demonstrate the robust evolutionmore » and stability of planar fronts. Moreover, our simulations also suggest the radial fronts tend to either annihilate or expand and flatten out, depending on the phase value inside and the parameter regime. Finally, we observe that solutions that initially feature two symmetric fronts with bulged centers evolve in qualitative agreement with experimental observations of phosphenes.« less
Entropic information for travelling solitons in Lorentz and CPT breaking systems
Correa, R.A.C.; Rocha, Roldão da; Souza Dutra, A. de
In this work we group four research topics apparently disconnected, namely solitons, Lorentz symmetry breaking, supersymmetry, and entropy. Following a recent work (Gleiser and Stamatopoulos, 2012), we show that it is possible to construct in the context of travelling wave solutions a configurational entropy measure in functional space, from the field configurations. Thus, we investigate the existence and properties of travelling solitons in Lorentz and CPT breaking scenarios for a class of models with two interacting scalar fields. Here, we obtain a complete set of exact solutions for the model studied which display both double and single-kink configurations. In fact, such models are very important in applications that include Bloch branes, Skyrmions, Yang–Mills, Q-balls, oscillons and various superstring-motivated theories. We find that the so-called Configurational Entropy (CE) for travelling solitons shows that the best value of parameter responsible to break the Lorentz symmetry is one where the energy density is distributed equally around the origin. In this way, the information-theoretical measure of travelling solitons in Lorentz symmetry violation scenarios opens a new window to probe situations where the parameters responsible for breaking the symmetries are arbitrary. In this case, the CE selects the best value of the parameter in the model.
High speed, long distance, data transmission multiplexing circuit
Mariotti, Razvan
A high speed serial data transmission multiplexing circuit, which is operable to accurately transmit data over long distances (up to 3 Km), and to multiplex, select and continuously display real time analog signals in a bandwidth from DC to 100 Khz. The circuit is made fault tolerant by use of a programmable flywheel algorithm, which enables the circuit to tolerate one transmission error before losing synchronization of the transmitted frames of data. A method of encoding and framing captured and transmitted data is used which has a low overhead and prevents some particular transmitted data patterns from locking an included detector/decoder circuit.
A Graph Search Heuristic for Shortest Distance Paths
Chow, E
This paper presents a heuristic for guiding A* search for finding the shortest distance path between two vertices in a connected, undirected, and explicitly stored graph. The heuristic requires a small amount of data to be stored at each vertex. The heuristic has application to quickly detecting relationships between two vertices in a large information or knowledge network. We compare the performance of this heuristic with breadth-first search on graphs with various topological properties. The results show that one or more orders of magnitude improvement in the number of vertices expanded is possible for large graphs, including Poisson random graphs.
The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1
Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian
Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.
Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment
Auty, David John
The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the
,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"
Energy Information Administration (EIA) (indexed site)
Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File
,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"
Energy Information Administration (EIA) (indexed site)
Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File
Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per
Energy Information Administration (EIA) (indexed site)
Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of
,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"
Energy Information Administration (EIA) (indexed site)
Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File
,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"
Energy Information Administration (EIA) (indexed site)
Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File
A comparison of standard evasion scenarios at near regional distances
Bos, R.; App, F.; Jones, E.; Dey, T.; Kamm, J.
We performed numerical simulations of three nuclear testing evasion scenarios. These calculations were done in two parts. The first part was done near source (within 10 km) with a non-linear weapons effects code. Particle velocity histories from the non-linear code were linked to an elastic linear finite-difference code for the second part. Seismic waveforms from the evasion scenario calculations were compared with the waveforms for a non-evasive explosion calculation at near regional distances. The results of this comparison suggest that it may be important to include realistic stratigraphy in such simulations: the overall wave amplitude in the present simulations is reduced by only a factor of 3-5 in contradiction to factors of 20-100 in {open_quotes}classical{close_quotes} decoupling analyses for ideal (i.e., unlayered) media. Two of the evasion scenarios simulated retain explosive waveform characteristics at near regional distances, while the third scenario indicates that certain source geometries might lead to more non-explosive (i.e., earthquake-like) seismic signals.
Nonlinear, noniterative, single-distance phase retrieval and developmental biology
Moosmann, Julian; Altapova, Venera; Haenschke, Daniel; Hofmann, Ralf; Baumbach, Tilo
For coherent X-ray imaging, based on phase contrast through free-space Fresnel propagation, we discuss two noniterative, nonlinear approaches to the phase-retrieval problem from a single-distance intensity map of a pure-phase object. On one hand, a perturbative set-up is proposed where nonlinear corrections to the linearized transport-of-intensity situation are expanded in powers of the object-detector distance z and are evaluated in terms of the linear estimate. On the other hand, a nonperturbative projection algorithm, which is based on the (linear and local) contrast-transfer function (CTF), works with an effective phase in Fourier space. This effective phase obeys a modified CTF relation between intensity contrast at z > 0 and phase contrast at z= 0: Unphysical singularities of the local CTF model are cut off to yield 'quasiparticles' in analogy to the theory of the Fermi liquid. By identifying the positions of the zeros of the Fourier transformed intensity contrast as order parameters for the dynamical breaking of scaling symmetry we investigate the phase structure of the forward-propagation problem when interpreted as a statistical system. Results justify the quasiparticle approach for a wide range of intermediary phase variations. The latter algorithm is applied to data from biological samples recorded at the beamlines TopoTomo and ID19 at ANKA and ESRF, respectively.
Red giant stars from the Sloan digital sky survey. II. Distances
Tan, Kefeng; Chen, Yuqin; Carrell, Kenneth; Zhao, Jingkun; Zhao, Gang
We present distance determinations for a large and clean sample of red giant branch stars selected from the ninth data release of the Sloan Digital Sky Survey. The distances are calculated based on both observational cluster fiducials and theoretical isochrones. Distributions of distances from the two methods are very similar with peaks at about 10 kpc and tails extending to more than 70 kpc. We find that distances from the two methods agree well for the majority of the sample stars; though, on average, distances based on isochrones are 10% higher than those based on fiducials. We test the accuracy of our distance determinations using 332 stars from 10 Galactic globular and open clusters. The average relative deviation from the literature cluster distances is 4% for the fiducial-based distances and 8% for the isochrone-based distances, both of which are within the uncertainties. We find that the effective temperature and surface gravity derived from low-resolution spectra are not accurate enough to essentially improve the performance of distance determinations. However, for stars with significant extinction, effective temperature may help to better constrain their distances to some extent. We make our sample stars and their distances available from an online catalog. The catalog comprises 17,941 stars with reasonable distance estimations reaching to more than 70 kpc, which is suitable for the investigation of the formation and evolution of the Galaxy, especially the Galactic halo.
Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations
Martens, Mike; /Fermilab
This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.
Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene
Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng
MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.
miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2
Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian
Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.
One-dimensional kinetic description of nonlinear traveling-pulse and traveling-wave disturbances in long coasting charged particle beams
Davidson, Ronald C.; Qin, Hong
This paper makes use of a one-dimensional kinetic model to investigate the nonlinear longitudinal dynamics of a long coasting beam propagating through a perfectly conducting circular pipe with radius r w . The average axial electric field is expressed as z >=�(?/?z)=�ebg???b/?z � ebg2r2w?3?b/?z3, where g0 and g2 are constant geometric factors, ?b(z,t)=?dpz Fb (z,pz,t) is the line density of beam particles, and F b (z,pz,t) satisfies the 1D Vlasov equation. Detailed nonlinear properties of traveling-wave and traveling-pulse (soliton) solutions with time-stationary waveform are examined for a wide range of system parameters extending from moderate-amplitudes to large-amplitude modulations ofmore��the beam charge density. Two classes of solutions for the beam distribution function are considered, corresponding to: (i) the nonlinear waterbag distribution, where Fb = const in a bounded region of pz-space; and (ii) nonlinear Bernstein-Green-Kruskal (BGK)-like solutions, allowing for both trapped and untrapped particle distributions to interact with the self-generated electric field.��less
,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"
Energy Information Administration (EIA) (indexed site)
Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release
Large neighborhood search for the double traveling salesman problem with multiple stacks
Bent, Russell W; Van Hentenryck, Pascal
This paper considers a complex real-life short-haul/long haul pickup and delivery application. The problem can be modeled as double traveling salesman problem (TSP) in which the pickups and the deliveries happen in the first and second TSPs respectively. Moreover, the application features multiple stacks in which the items must be stored and the pickups and deliveries must take place in reserve (LIFO) order for each stack. The goal is to minimize the total travel time satisfying these constraints. This paper presents a large neighborhood search (LNS) algorithm which improves the best-known results on 65% of the available instances and is always within 2% of the best-known solutions.
Energy Secretary Steven Chu to Travel to Bay Area to Highlight State of the
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Union Address, Commitment to Clean Energy | Department of Energy Bay Area to Highlight State of the Union Address, Commitment to Clean Energy Energy Secretary Steven Chu to Travel to Bay Area to Highlight State of the Union Address, Commitment to Clean Energy January 31, 2012 - 7:38pm Addthis Washington, D.C. - As part of the Energy Department's ongoing efforts to highlight President Obama's State of the Union address and discuss the Obama Administration's commitment to American energy
Local Teams from PA, WV Travel to Washington D.C. for National Science Bowl
U.S. Department of Energy (DOE) - all webpages (Extended Search)
| netl.doe.gov Regional News Local Teams from PA, WV Travel to Washington D.C. for National Science Bowl Pittsburgh, Pa. - The National Energy Technology Laboratory have sent the regional winners of the southwestern Pennsylvania (SWPA) and West Virginia Science Bowls off to compete in the U.S. Department of Energy National Science Bowl April 28-May 2, 2016, in Washington, D.C. By winning their regional tournaments, the Marshall Middle School (Wexford, PA), Morgantown High School (Morgantown,
Design and fabrication of a traveling-wave muffin-tin accelerating structure at 90 GHz
Chou, P.J.; Bowden, G.B.; Copeland, M.R.; Menegat, A.; Siemann, R.H.; Henke, H.
A prototype of a muffin-tin accelerating structure operating at 32 times the SLAC frequency (2.856 GHz) was built for research in high gradient acceleration. A traveling-wave design with single input and output feeds was chosen for the prototype which was fabricated by wire electrodischarge machining. Features of the mechanical design for the prototype are described. Design improvements are presented including considerations of cooling and vacuum.
Time domain analysis of a gyrotron traveling wave amplifier with misaligned electron beam
Wang, Qiushi Peng, Shuyuan; Luo, Jirun
This article develops a time-domain theory to study the beam-wave interaction in gyrotron traveling wave amplifier (gyro-TWA) with a misaligned electron beam. The effects of beam misalignment on the TE{sub 01} mode gyro-TWA operating at the fundamental are discussed. Numerical results show that the effect of misalignment is less obvious when the input power is larger, and the influences of misalignment on the stable gain and the stable time are basically opposite.
Market and energy demand analysis of a US maglev system
Vyas, A.D.; Rote, D.M.
High-speed magnetically levitated (maglev) vehicles can provide an alternative mode of transportation for intercity travel, particularly for short- and medium-distance trips between 100 to 600 mi (160 and 960 km). The patterns of growth and the underlying factors affecting that growth In the year 2010 are evaluated to determine the magnitude of US Intercity travel that would become the basis for maglev demand. A methodology that is sensitive to the travelers` socioeconomic attributes was developed to Forecast intercity travel. Travel between 78 major metropolitan areas by air and highway modes is projected, and 12 high-density travel corridors are Identified and selected. The potential for a maglev system to substitute for part or that travel is calculated by using a model that estimates the extent of diversion from highway and air to maglev. Energy demand is estimated on the basis of energy usage during acceleration and cruise phases for each corridor and corridor connections.
Market and energy demand analysis of a US maglev system
Vyas, A.D.; Rote, D.M.
High-speed magnetically levitated (maglev) vehicles can provide an alternative mode of transportation for intercity travel, particularly for short- and medium-distance trips between 100 to 600 mi (160 and 960 km). The patterns of growth and the underlying factors affecting that growth In the year 2010 are evaluated to determine the magnitude of US Intercity travel that would become the basis for maglev demand. A methodology that is sensitive to the travelers' socioeconomic attributes was developed to Forecast intercity travel. Travel between 78 major metropolitan areas by air and highway modes is projected, and 12 high-density travel corridors are Identified and selected. The potential for a maglev system to substitute for part or that travel is calculated by using a model that estimates the extent of diversion from highway and air to maglev. Energy demand is estimated on the basis of energy usage during acceleration and cruise phases for each corridor and corridor connections.
miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2
Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong
Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.
MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan
Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.
Analysis of the Argonne distance tabletop exercise method.
Tanzman, E. A.; Nieves, L. A.; Decision and Information Sciences
The purpose of this report is to summarize and evaluate the Argonne Distance Tabletop Exercise (DISTEX) method. DISTEX is intended to facilitate multi-organization, multi-objective tabletop emergency response exercises that permit players to participate from their own facility's incident command center. This report is based on experience during its first use during the FluNami 2007 exercise, which took place from September 19-October 17, 2007. FluNami 2007 exercised the response of local public health officials and hospitals to a hypothetical pandemic flu outbreak. The underlying purpose of the DISTEX method is to make tabletop exercising more effective and more convenient for playing organizations. It combines elements of traditional tabletop exercising, such as scenario discussions and scenario injects, with distance learning technologies. This distance-learning approach also allows playing organizations to include a broader range of staff in the exercise. An average of 81.25 persons participated in each weekly webcast session from all playing organizations combined. The DISTEX method required development of several components. The exercise objectives were based on the U.S. Department of Homeland Security's Target Capabilities List. The ten playing organizations included four public health departments and six hospitals in the Chicago area. An extent-of-play agreement identified the objectives applicable to each organization. A scenario was developed to drive the exercise over its five-week life. Weekly problem-solving task sets were designed to address objectives that could not be addressed fully during webcast sessions, as well as to involve additional playing organization staff. Injects were developed to drive play between webcast sessions, and, in some cases, featured mock media stories based in part on player actions as identified from the problem-solving tasks. The weekly 90-minute webcast sessions were discussions among the playing organizations that were
Final Report Phase I Study to Characterize the Market Potential for Non-Motorized Travel
Hwang, Ho-Ling; Reuscher, Tim; Wilson, Daniel W; Schmoyer, Richard L
The idea of livable communities suggests that people should have the option to utilize non-motorized travel (NMT), specifically walking and bicycling, to conduct their daily tasks. Forecasting personal travel by walk and bike is necessary as part of regional transportation planning, and requires fine detail not only about individual travel, but also on transportation and neighborhood infrastructure. In an attempt to characterize the 'market' potential for NMT, the Office of Planning, Federal Highway Administration (FHWA) funded the Center for Transportation Analysis (CTA) of the Oak Ridge National Laboratory (ORNL) to conduct a study. The objectives of this effort were to identify factors that influence communities to walk and bike and to examine why, or why not, travelers walk and bike in their communities. This study relied on information collected under the 2009 National Household Travel Survey (NHTS) as the major source of data, and was supplemented with data from the American Community Survey (ACS), educational survey, health, employment, and others. Initial statistical screening methods were applied to sort through over 400 potential predictor variables, and examined with various measures (e.g., walk trip per person, walk mileage per person, bike trip per person, bike mileage per person) as the dependent variables. The best geographic level of detail used in the modeling for this study was determined to be the Census block group level for walking and Census tract level for biking. The need for additional supplemental private data (i.e., Walk Scores and Nielsen employment data), and geospatial information that reflects land use and physical environments, became evident after an examination of findings from the initial screening models. To be feasible, in terms of costs and time, the geographic scale of the study region was scaled down to nine selected NHTS add-on regions. These regions were chosen based on various criteria including transit availability
Notice of Intent to Submit Page Changes to Revise DOE O 552.1A, Travel Policy and Procedures
Directives, Delegations, and Other Requirements [Office of Management (MA)]
A page change is being undertaken to reflect changes in responsibilities brought about by the August 2013 reorganization which transferred travel related functions and systems between the Office of Chief Financial Officer (OCFO) and the Office of Management (MA).
Notice of Intent to Submit Page Changes to Revise DOE O 552.1A, Travel Policy and Procedures
Directives, Delegations, and Other Requirements [Office of Management (MA)]
A page-change is being undertaken to reflect changes in responsibilities brought about by the August 2013 reorganization which transferred travel related functions and systems between the Office of Chief Financial Officer (OCFO) and the Office of Management (MA).
miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway
Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi
Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.
U.S. Department of Energy (DOE) - all webpages (Extended Search)
of our science, people, technologies close Grape Growers Association enlivens agriculture Entrepreneurial Networking Program unites New Mexico grape growers for successful...
Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions (Transportation Energy Futures Series)
U.S. Department of Energy (DOE) - all webpages (Extended Search)
DEMAND Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions TRANSPORTATION ENERGY FUTURES SERIES: Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions A Study Sponsored by U.S. Department of Energy Office of Energy Efficiency and Renewable Energy March 2013 Prepared by CAMBRIDGE SYSTEMATICS Cambridge, MA 02140 under subcontract DGJ-1-11857-01 Technical monitoring performed by NATIONAL
St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)
Energy Information Administration (EIA) (indexed site)
Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural
Weinberger, Alycia J.; Boss, Alan P.; Anglada-Escude, Guillem
From common proper motion and signatures of youth, researchers have identified about 30 members of a putative TW Hydrae Association. Only four of these had parallactic distances from Hipparcos. We have measured parallaxes and proper motions for 14 primary members. We combine these with literature values of radial velocities to show that the Galactic space motions of the stars, with the exception of TWA 9 and 22, are parallel and do not indicate convergence at a common formation point sometime in the last few million years. The space motions of TWA 9 and 22 do not agree with the others and indicate that they are not TWA members. The median parallax is 18 mas or 56 pc. We further analyze the stars' absolute magnitudes on pre-main-sequence evolutionary tracks and find a range of ages with a median of 10.1 Myr and no correlation between age and Galactic location. The TWA stars may have formed from an extended and filamentary molecular cloud but are not necessarily precisely coeval.
Observation of Disappearance of Muon Neutrinos in the NuMI Beam
Pavlovic, Zarko
The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin22θ23 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin2 2θ23 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.
Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter
J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester
Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.
T-1025 IU SciBath-768 detector tests in MI-12
Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab
This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.
MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA
Zhang, Weiying; Lu, Zhanping; Gao, Yuen; Ye, Lihong; Song, Tianqiang; Zhang, Xiaodong
Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.
A large catalog of accurate distances to molecular clouds from PS1 photometry
Schlafly, E. F.; Rix, H.-W.; Martin, N. F.; Green, G.; Finkbeiner, D. P.; Bell, E. F.; Burgett, W. S.; Chambers, K. C.; Hodapp, K. W.; Kaiser, N.; Magnier, E. A.; Tonry, J. L.; Draper, P. W.; Metcalfe, N.; Price, P. A.
Distance measurements to molecular clouds are important but are often made separately for each cloud of interest, employing very different data and techniques. We present a large, homogeneous catalog of distances to molecular clouds, most of which are of unprecedented accuracy. We determine distances using optical photometry of stars along lines of sight toward these clouds, obtained from PanSTARRS-1. We simultaneously infer the reddenings and distances to these stars, tracking the full probability distribution function using a technique presented in Green et al. We fit these star-by-star measurements using a simple dust screen model to find the distance to each cloud. We thus estimate the distances to almost all of the clouds in the Magnani et al. catalog, as well as many other well-studied clouds, including Orion, Perseus, Taurus, Cepheus, Polaris, California, and Monoceros R2, avoiding only the inner Galaxy. Typical statistical uncertainties in the distances are 5%, though the systematic uncertainty stemming from the quality of our stellar models is about 10%. The resulting catalog is the largest catalog of accurate, directly measured distances to molecular clouds. Our distance estimates are generally consistent with available distance estimates from the literature, though in some cases the literature estimates are off by a factor of more than two.
Comparison of actinide production in traveling wave and pressurized water reactors
Osborne, A.G.; Smith, T.A.; Deinert, M.R.
The geopolitical problems associated with civilian nuclear energy production arise in part from the accumulation of transuranics in spent nuclear fuel. A traveling wave reactor is a type of breed-burn reactor that could, if feasible, reduce the overall production of transuranics. In one possible configuration, a cylinder of natural or depleted uranium would be subjected to a fast neutron flux at one end. The neutrons would transmute the uranium, producing plutonium and higher actinides. Under the right conditions, the reactor could become critical, at which point a self-stabilizing fission wave would form and propagate down the length of the reactor cylinder. The neutrons from the fission wave would burn the fissile nuclides and transmute uranium ahead of the wave to produce additional fuel. Fission waves in uranium are driven largely by the production and fission of {sup 239}Pu. Simulations have shown that the fuel burnup can reach values greater than 400 MWd/kgIHM, before fission products poison the reaction. In this work we compare the production of plutonium and minor actinides produced in a fission wave to that of a UOX fueled light water reactor, both on an energy normalized basis. The nuclide concentrations in the spent traveling wave reactor fuel are computed using a one-group diffusion model and are verified using Monte Carlo simulations. In the case of the pressurized water reactor, a multi-group collision probability model is used to generate the nuclide quantities. We find that the traveling wave reactor produces about 0.187 g/MWd/kgIHM of transuranics compared to 0.413 g/MWd/kgIHM for a pressurized water reactor running fuel enriched to 4.95 % and burned to 50 MWd/kgIHM. (authors)
Help or hindrance? The travel, energy and carbon impacts of highly automated vehicles
Wadud, Zia; MacKenzie, Don; Leiby, Paul
In 5-10 years, experts predict that new automobiles will be capable of driving themselves under limited conditions and under most conditions within 10–20 years. Automation may affect road vehicle energy consumption and greenhouse gas (GHG) emissions in a host of ways, positive and negative, by causing changes in travel demand, vehicle design, vehicle operating profiles, and choices of fuels. In this paper, we identify specific mechanisms through which automation may affect travel and energy demand and resulting GHG emissions and bring them together using a coherent energy decomposition framework. Here, we review the literature for estimates of the energy impactsmore » of each mechanism and, where the literature is lacking, develop our own estimates using engineering and economic analysis. We consider how widely applicable each mechanism is, and quantify the potential impact of each mechanism on a common basis: the percentage change it is expected to cause in total GHG emissions from light-duty or heavy-duty vehicles in the U.S. Our primary focus is travel related energy consumption and emissions, since potential lifecycle impacts are generally smaller in magnitude. We also explore the net effects of automation on emissions through several illustrative scenarios, finding that automation might plausibly reduce road transport GHG emissions and energy use by nearly half – or nearly double them – depending on which effects come to dominate. We also find that many potential energy-reduction benefits may be realized through partial automation, while the major energy/emission downside risks appear more likely at full automation. Finally, we present some implications for policymakers and identifying priority areas for further research.« less
Sensors closeness test based on an improved [0, 1] bounded Mahalanobis distance Δ{sup 2}
Masnan, Maz Jamilah; Mahat, Nor Idayu; Shakaff, Ali Yeon Md Abdullah, Abu Hassan
Mahalanobis distance Δ{sup 2} values are commonly in the range of 0 to +∞ where higher values represent greater distance between class means or points. The increase in Mahalanobis distance is unbounded as the distance multiply. To certain extend, the unbounded distance values pose difficulties in the evaluation and decision for instance in the sensors closeness test. This paper proposes an approach to [0, 1] bounded Mahalanobis distance Δ{sup 2} that enable researcher to easily perform sensors closeness test. The experimental data of four different types of rice based on three different electronic nose sensors namely InSniff, PEN3, and Cyranose320 were analyzed and sensor closeness test seems successfully performed within the [0, 1] bound.
Travelling fronts of the CO oxidation on Pd(111) with coverage-dependent diffusion
Cisternas, Jaime, E-mail: firstname.lastname@example.com [Facultad de Ingenier�a y Ciencias Aplicadas, Universidad de los Andes, Monse�or Alvaro del Portillo 12455, Las Condes, Santiago (Chile); Karpitschka, Stefan [Physics of Fluids, University of Twente, Drienerlolaan 5, 7522 NB Enschede (Netherlands); Wehner, Stefan [Institut f�r Integrierte Naturwissenschaften - Physik, Universit�t Koblenz-Landau, 56070 Koblenz (Germany)
In this work, we study a surface reaction on Pd(111) crystals under ultra-high-vacuum conditions that can be modeled by two coupled reaction-diffusion equations. In the bistable regime, the reaction exhibits travelling fronts that can be observed experimentally using photo electron emission microscopy. The spatial profile of the fronts reveals a coverage-dependent diffusivity for one of the species. We propose a method to solve the nonlinear eigenvalue problem and compute the direction and the speed of the fronts based on a geometrical construction in phase-space. This method successfully captures the dependence of the speed on control parameters and diffusivities.
Integrating a Traveling Wave Tube into an AECR-U ion source
Covo, Michel Kireeff; Benitez, Janilee Y.; Ratti, Alessandro; Vujic, Jasmina L.
An RF system of 500W - 10.75 to 12.75 GHz was designed and integrated into the Advanced Electron Cyclotron Resonance - Upgrade (AECR-U) ion source of the 88-Inch Cyclotron at Lawrence Berkeley National Laboratory. The AECR-U produces ion beams for the Cyclotron giving large flexibility of ion species and charge states. The broadband frequency of a Traveling Wave Tube (TWT) allows modifying the volume that couples and heats the plasma. The TWT system design and integration with the AECR-U ion source and results from commissioning are presented.
Distance growth of quantum states due to initial system-environment correlations
Dajka, J.; Luczka, J.
Intriguing features of the distance between two arbitrary states of an open quantum system are identified that are induced by initial system-environment correlations. As an example, we analyze a qubit dephasingly coupled to a bosonic environment. Within tailored parameter regimes, initial correlations are shown to substantially increase the distance between two qubit states evolving to long-time-limit states according to exact non-Markovian dynamics. It exemplifies the breakdown of the distance contractivity of the reduced dynamics.
Long distance symmetries for nuclear forces and the similarity renormalization group
Szpigel, S.; Timoteo, V. S.; Arriola, E. R.
In this work we study the emergence of long distance symmetries for nuclear forces within the framework of the similarity renormalization group approach.
The Araucaria project. The distance to the small Magellanic Cloud from late-type eclipsing binaries
Graczyk, Dariusz; Pietrzyński, Grzegorz; Gieren, Wolfgang; Pilecki, Bogumił; Villanova, Sandro; Gallenne, Alexandre; Thompson, Ian B.; Konorski, Piotr; Udalski, Andrzej; Soszyński, Igor; Górski, Marek; Suchomska, Ksenia; Karczmarek, Paulina; Kudritzki, Rolf-Peter; Bresolin, Fabio
We present a distance determination to the Small Magellanic Cloud (SMC) based on an analysis of four detached, long-period, late-type eclipsing binaries discovered by the Optical Gravitational Lensing Experiment (OGLE) survey. The components of the binaries show negligible intrinsic variability. A consistent set of stellar parameters was derived with low statistical and systematic uncertainty. The absolute dimensions of the stars are calculated with a precision of better than 3%. The surface brightness-infrared color relation was used to derive the distance to each binary. The four systems clump around a distance modulus of (m – M) = 18.99 with a dispersion of only 0.05 mag. Combining these results with the distance published by Graczyk et al. for the eclipsing binary OGLE SMC113.3 4007, we obtain a mean distance modulus to the SMC of 18.965 ± 0.025 (stat.) ± 0.048 (syst.) mag. This corresponds to a distance of 62.1 ± 1.9 kpc, where the error includes both uncertainties. Taking into account other recent published determinations of the SMC distance we calculated the distance modulus difference between the SMC and the Large Magellanic Cloud equal to 0.458 ± 0.068 mag. Finally, we advocate μ{sub SMC} = 18.95 ± 0.07 as a new 'canonical' value of the distance modulus to this galaxy.
Anomalous expansion of the copper-apical-oxygen distance in supercondu...
Office of Scientific and Technical Information (OSTI)
Anomalous expansion of the copper-apical-oxygen distance in superconducting cuprate bilayers Citation Details In-Document Search Title: Anomalous expansion of the copper-apical-oxy...
Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations
Hamid, Ahmed M.; Ibrahim, Yehia M.; Garimella, Venkata BS; Webb, Ian K.; Deng, Liulin; Chen, Tsung-Chi; Anderson, Gordon A.; Prost, Spencer A.; Norheim, Randolph V.; Tolmachev, Aleksey V.; Smith, Richard D.
We report on the development and characterization of a new traveling wave-based Structure for Lossless Ion Manipulations (TW-SLIM) for ion mobility separations (IMS). The TW-SLIM module uses a parallel array of RF electrodes for ion confinement, spaced by an array of short DC electrodes to which a TW can be applied to drive ion motion. The ability of the TW-SLIM for efficient ion confinement, lossless ion transport, and ion mobility separations at different RF and TW parameters is reported. The TW-SLIM module is shown to allow transfers a wide mass range of ions (200-2500 Da) utilizing a confining RF waveform (1 MHz and 300 Vp-p), and low TW amplitudes (<20 V). Also, the short module achieved an ion mobility peak capacity of 24 and a peak generation rate of 1014 s-1 for TW speeds of <210 m/s. TW-SLIM performance was characterized over a wide range of RF and DC voltage parameters, and demonstrated robust performance. The combined attributes of flexible design and low voltage requirements for traveling wave IMS, provide a basis for SLIM devices incorporating extended series of ion manipulations.
Simulation studies on the standing and traveling wave thermoacoustic prime movers
Skaria, Mathew; Rasheed, K. K. Abdul; Shafi, K. A.; Kasthurirengan, S.; Behera, Upendra
Thermoacoustic systems have been a focus of recent research due to its structural simplicity, high reliability due to absence of moving parts, and can be driven by low grade energy such as fuel, gas, solar energy, waste heat etc. There has been extensive research on both standing wave and traveling wave systems. Towards the development of such systems, simulations can be carried out by several methods such as (a) solving the energy equation, (b) enthalpy flow model, (c) DeltaEC, a free software available from LANL, USA (d) Computational Fluid Dynamics (CFD) etc. We present here the simulation studies of standing wave and traveling wave thermoacoustic prime movers using CFD and DeltaEC. The CFD analysis is carried out using Fluent 6.3.26, incorporating the necessary boundary conditions with different working fluids at different operating pressures. The results obtained by CFD are compared with those obtained using DeltaEC. Also, the CFD simulation of the thermoacoustically driven refrigerator is presented.
Cost Analysis of Plug-In Hybred Electric Vehicles Using GPS-Based Longitudinal Travel Data
Wu, Xing; Dong, Jing; Lin, Zhenhong
Using spatial, longitudinal travel data of 415 vehicles over 3 18 months in the Seattle metropolitan area, this paper estimates the operating costs of plug-in hybrid electric vehicles (PHEVs) of various electric ranges (10, 20, 30, and 40 miles) for 3, 5, and 10 years of payback period, considering different charging infrastructure deployment levels and gasoline prices. Some key findings were made. (1) PHEVs could help save around 60% or 40% in energy costs, compared with conventional gasoline vehicles (CGVs) or hybrid electric vehicles (HEVs), respectively. However, for motorists whose daily vehicle miles traveled (DVMT) is significant, HEVs may be even a better choice than PHEV40s, particularly in areas that lack a public charging infrastructure. (2) The incremental battery cost of large-battery PHEVs is difficult to justify based on the incremental savings of PHEVs operating costs unless a subsidy is offered for largebattery PHEVs. (3) When the price of gasoline increases from $4/gallon to $5/gallon, the number of drivers who benefit from a larger battery increases significantly. (4) Although quick chargers can reduce charging time, they contribute little to energy cost savings for PHEVs, as opposed to Level-II chargers.
Characterizing Walk Trips in communities by Using Data from 2009 National Household Travel Survey, American Community Survey, and Other Sources
Hwang, Ho-Ling; Reuscher, Tim; Wilson, Daniel W; Murakami, Elaine
Non-motorized travel (i.e. walking and bicycling) are of increasing interest to the transportation profession, especially in context with energy consumption, reducing vehicular congestion, urban development patterns, and promotion of healthier life styles. This research project aimed to identify factors impacting the amount of travel for both walk and bike trips at the Census block group or tract level, using several public and private data sources. The key survey of travel behavior is the 2009 National Household Travel Survey (NHTS) which had over 87,000 walk trips for persons 16 and over, and over 6000 bike trips for persons 16 and over. The NHTS, in conjunction with the Census Bureau s American Community Survey, street density measures using Census Bureau TIGER, WalkScore , Nielsen Claritas employment estimates, and several other sources were used for this study. Stepwise Logistic Regression modeling techniques as well as Discriminant Analysis were applied using the integrated data set. While the models performed reasonably well for walk trips, travel by bike was abandoned due to sparseness of data. This paper discusses data sources utilized and modeling processes conducted under this study. It also presents a summary of findings and addresses data challenges and lesson-learned from this research effort.
The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a
Hu, Cheng-En; Liu, Yong-Chao; Zhang, Hui-Dong; Huang, Guang-Jian
Highlights: • PCBP2 is overexpressed in human gastric cancer. • PCBP2 high expression predicts poor survival. • PCBP2 regulates gastric cancer growth in vitro and in vivo. • PCBP2 regulates gastric cancer apoptosis by targeting miR-34a. - Abstract: Gastric carcinoma is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. However, the mechanism underling gastric cancer is still not fully understood. Here in the present study, we identify the RNA-binding protein PCBP2 as an oncogenic protein in human gastric carcinoma. Our results show that PCBP2 is up-regulated in human gastric cancer tissues compared to adjacent normal tissues, and that high level of PCBP2 predicts poor overall and disease-free survival. Knockdown of PCBP2 in gastric cancer cells inhibits cell proliferation and colony formation in vitro, whereas opposing results are obtained when PCBP2 is overexpressed. Our in vivo subcutaneous xenograft results also show that PCBP2 can critically regulate gastric cancer cell growth. In addition, we find that PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, we identify that miR-34a as a target of PCBP2, and that miR-34a is critically essential for the function of PCBP2. In summary, PCBP2 promotes gastric carcinoma development by regulating the level of miR-34a.
Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a
Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun
Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by
[Trip report of travel to Las Vegas to consider specification for the Integrated Data System (IDS) with administrative memos]. Volume 1, FY92--FY93
Hall, J.
This document is a compilation of travel reports and memorandums that are the results of planning between Los Alamos National Laboratory and Computer Applications Group, Inc.
Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland
Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.
One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.
A Flexible Baseline Design for the Advanced High Temperature Reactor Using Metallic Internals (AHTR-MI)
Peterson, Per F.; Haihua, Zhao
The Advanced High Temperature Reactor (AHTR) is a novel reactor concept that uses clean liquid fluoride salts as a high temperature primary coolant for conventional graphite matrix, coated particle fuels. The very large volumetric heat capacity and excellent natural circulation heat transfer provided by liquid salts enables the design of high-temperature reactors with passive safety features and thermal powers ranging from 2400 to 4000 MW(t). To make optimal use of existing design information, early AHTR designs were modeled upon the S-PRISM sodium pool-reactor design, but introduced an insulated reactor vessel. Subsequent work has shown that liquid-salt cooled systems share important similarities with pressurized water reactors, which use a closed primary loop. This article discusses the use of a closed primary loop immersed in a separate buffer salt tank, which permits the primary loop components to be fabricated from metallic materials (AHTR-MI). This approach may provide several key advantages over open loop approaches, including very large thermal inertia. (authors)
The effect of travel speed on thermal response in CO{sub 2} laser welding of small electronic components
Gianoulakis, S.E.; Burchett, S.N.; Fuerschbach, P.W.; Knorovsky, G.A.
A comprehensive three-dimensional numerical investigation of the effect of heat source travel speed on temperatures and resulting thermal stresses was performed for CO{sub 2}-laser welding. The test specimen was a small thermal battery header containing several stress-sensitive glass-to-metal seals surrounding the electrical connections and a temperature sensitive ignitor located under the header near the center. Predictions of the thermal stresses and temperatures in the battery header were made for several travel speeds of the laser. The travel speeds examined ranged from 10 mm/sec to 50 mm/sec. The results indicate that faster weld speeds result in lower temperatures and stresses for the same size weld. This is because the higher speed welds are more efficient, requiring less energy to produce a given weld. Less energy absorbed by the workpiece results in lower temperatures, which results in lower stresses.
The effect of travel speed on thermal response in CO{sub 2} laser welding of small electronic components
Gianoulakis, S.E.; Burchett, S.N.; Fuerschbach, P.W.; Knorovsky, G.A.
A comprehensive three-dimensional numerical investigation of the effect of beat source travel speed on temperatures and resulting thermal stresses was performed for CO{sub 2}-laser welding. The test specimen was a small thermal battery header containing several stress-sensitive glass-to-metal seals surrounding the electrical connections and a temperature sensitive ignitor located under the header near the center. Predictions of the thermal stresses and temperatures in the battery header were made for several travel speeds of the laser. The travel speeds examined ranged from 10mm/sec to 50mm/sec. The results indicate that faster weld speeds result in lower temperatures and stresses for the same size weld. This is because the higher speed welds are more efficient, requiring less energy to produce a given weld. Less energy absorbed by the workpiece results in lower temperatures, which results in lower stresses.
Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer
Li, Weina; He, Fei
Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.
Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group
Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley
We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to
Wave coupling in sheet- and multiple-beam traveling-wave tubes
Nusinovich, Gregory S.; Cooke, Simon J.; Levush, Baruch; Botton, Moti
To increase the power level of the sources of coherent electromagnetic radiation at frequencies from 100 GHz up to the terahertz range it makes sense to develop devices with a spatially extended interaction space. Sheet-beam and multiple-beam devices belong to the category. In the present paper the small-signal theory of traveling-wave tubes with sheet-beam and multiple sheet-beam configurations is developed. It is shown that in such tubes the wave coupling on electron beams may occur even in small-signal regimes. The wave coupling and its role for amplification of forward and excitation of backward waves in such amplifiers is studied. Also the effect of transverse nonuniformity of the electromagnetic field on the device operation is analyzed and illustrated by several examples.
Traveling wave parametric amplifier with Josephson junctions using minimal resonator phase matching
White, T. C.; Mutus, J. Y.; Hoi, I.-C.; Barends, R.; Campbell, B.; Chen, Yu; Chen, Z.; Chiaro, B.; Dunsworth, A.; Jeffrey, E.; Kelly, J.; Neill, C.; O'Malley, P. J. J.; Roushan, P.; Sank, D.; Vainsencher, A.; Wenner, J.; Martinis, John M.; Megrant, A.; Chaudhuri, S.; and others
Josephson parametric amplifiers have become a critical tool in superconducting device physics due to their high gain and quantum-limited noise. Traveling wave parametric amplifiers (TWPAs) promise similar noise performance, while allowing for significant increases in both bandwidth and dynamic range. We present a TWPA device based on an LC-ladder transmission line of Josephson junctions and parallel plate capacitors using low-loss amorphous silicon dielectric. Crucially, we have inserted ?/4 resonators at regular intervals along the transmission line in order to maintain the phase matching condition between pump, signal, and idler and increase gain. We achieve an average gain of 12?dB across a 4?GHz span, along with an average saturation power of ?92 dBm with noise approaching the quantum limit.
Traveling waves for the mass in mass model of granular chains
Kevrekidis, Panayotis G.; Stefanov, Atanas G.; Xu, Haitao
In this work, we consider the mass in mass (or mass with mass) system of granular chains, namely, a granular chain involving additionally an internal (or, respectively, external) resonator. For these chains, we rigorously establish that under suitable "anti-resonance" conditions connecting the mass of the resonator and the speed of the wave, bell-shaped traveling-wave solutions continue to exist in the system, in a way reminiscent of the results proven for the standard granular chain of elastic Hertzian contacts. Finally, we also numerically touch upon settings, where the conditions do not hold, illustrating, in line also with recent experimental work, thatmore » non-monotonic waves bearing non-vanishing tails may exist in the latter case.« less
Preliminary performance of the MKII 17 GHz traveling wave relativistic klystron
Haimson, J.; Mecklenburg, B.; Stowell, G.; Kreischer, K. E.; Mastovsky, I. [Haimson Research Corporation, 3350 Scott Blvd., Building 60, Santa Clara, California 95054-3104 (United States); Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4294 (United States)
Initial test results are presented of an upgraded RF source developed for high peak power 17 GHz linear accelerator applications. The objectives of this upgrade program were (a) to increase the output capability of the existing vacuum demountable prototype tube so that RF power could also be supplied to a future 2 MeV photoinjector system without appreciable loss of input power to the 17 GHz linac and (b) to investigate the performance of a new design traveling wave output circuit incorporating a racetrack shaped dual output coupler with 5% bandwidth high peak power ceramic RF windows. These recently installed devices are presently being conditioned and tested at the MIT Plasma Science and Fusion Center.
Preliminary performance of the MKII 17 GHz traveling wave relativistic klystron
Haimson, J.; Mecklenburg, B.; Stowell, G. [Haimson Research Corporation, 3350 Scott Blvd., Building 60, Santa Clara, California 95054-3104 (United States); Kreischer, K.E.; Mastovsky, I. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4294 (United States)
Initial test results are presented of an upgraded RF source developed for high peak power 17 GHz linear accelerator applications. The objectives of this upgrade program were (a) to increase the output capability of the existing vacuum demountable prototype tube so that RF power could also be supplied to a future 2 MeV photoinjector system without appreciable loss of input power to the 17 GHz linac and (b) to investigate the performance of a new design traveling wave output circuit incorporating a racetrack shaped dual output coupler with 5{percent} bandwidth high peak power ceramic RF windows. These recently installed devices are presently being conditioned and tested at the MIT Plasma Science and Fusion Center. {copyright} {ital 1999 American Institute of Physics.}
Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT
Liu, Fabao; You, Xiaona; Chi, Xiumei; Wang, Tao; Ye, Lihong; Niu, Junqi; Zhang, Xiaodong
Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.
A study of muon neutrino disappearance in the MINOS detectors and the NuMI beam
Ling, Jiajie; /South Carolina U.
There is now substantial evidence that the proper description of neutrino involves two representations related by the 3 x 3 PMNS matrix characterized by either distinct mass or flavor. The parameters of this mixing matrix, three angles and a phase, as well as the mass differences between the three mass eigenstates must be determined experimentally. The Main Injector Neutrino Oscillation Search experiment is designed to study the flavor composition of a beam of muon neutrinos as it travels between the Near Detector at Fermi National Accelerator Laboratory at 1 km from the target, and the Far Detector in the Soudan iron mine in Minnesota at 735 km from the target. From the comparison of reconstructed neutrino energy spectra at the near and far location, precise measurements of neutrino oscillation parameters from muon neutrino disappearance and electron neutrino appearance are expected. It is very important to know the neutrino flux coming from the source in order to achieve the main goal of the MINOS experiment: precise measurements of the atmospheric mass splitting |{Delta}m{sub 23}{sup 2}|, sin{sup 2} {theta}{sub 23}. The goal of my thesis is to accurately predict the neutrino flux for the MINOS experiment and measure the neutrino mixing angle and atmospheric mass splitting.
Dynamic frequency-domain interferometer for absolute distance measurements with high resolution
Weng, Jidong; Liu, Shenggang; Ma, Heli; Tao, Tianjiong; Wang, Xiang; Liu, Cangli; Tan, Hua
A unique dynamic frequency-domain interferometer for absolute distance measurement has been developed recently. This paper presents the working principle of the new interferometric system, which uses a photonic crystal fiber to transmit the wide-spectrum light beams and a high-speed streak camera or frame camera to record the interference stripes. Preliminary measurements of harmonic vibrations of a speaker, driven by a radio, and the changes in the tip clearance of a rotating gear wheel show that this new type of interferometer has the ability to perform absolute distance measurements both with high time- and distance-resolution.
EPA Webinar- Travel Efficiency Assessment Method: Evaluating the Potential to Reduce Emissions in Three Case Study Areas
Office of Energy Efficiency and Renewable Energy (EERE)
The U.S. Environmental Protection Agency's (EPA) Office of Transportation and Air Quality is hosting a webinar describing EPA's recent case studies examining the potential for travel efficiency strategies (such as transit, road and parking pricing, land use changes, bike and pedestrian infrastructure) to reduce emissions of criteria pollutants and greenhouse gases.
Connes distance function on fuzzy sphere and the connection between geometry and statistics
Devi, Yendrembam Chaoba Chakraborty, Biswajit; Prajapat, Shivraj; Mukhopadhyay, Aritra K.; Scholtz, Frederik G.
An algorithm to compute Connes spectral distance, adaptable to the Hilbert-Schmidt operatorial formulation of non-commutative quantum mechanics, was developed earlier by introducing the appropriate spectral triple and used to compute infinitesimal distances in the Moyal plane, revealing a deep connection between geometry and statistics. In this paper, using the same algorithm, the Connes spectral distance has been calculated in the Hilbert-Schmidt operatorial formulation for the fuzzy sphere whose spatial coordinates satisfy the su(2) algebra. This has been computed for both the discrete and the Perelemov's SU(2) coherent state. Here also, we get a connection between geometry and statistics which is shown by computing the infinitesimal distance between mixed states on the quantum Hilbert space of a particular fuzzy sphere, indexed by n ∈ ℤ/2.
Building Better Batteries for Long-Distance Driving and Faster-Charging
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Electronics | Department of Energy Better Batteries for Long-Distance Driving and Faster-Charging Electronics Building Better Batteries for Long-Distance Driving and Faster-Charging Electronics March 2, 2016 - 10:07am Addthis The colors show the uneven distribution of chemical elements on this particle's surface, which is key to its improved performance in batteries. | Courtesy of Brookhaven National Laboratory and SLAC National Accelerator Laboratory. Karen McNulty Walsh Brookhaven National
Luminosity distance for Born-Infeld electromagnetic waves propagating in a cosmological magnetic background
Aiello, Matias; Bengochea, Gabriel R; Ferraro, Rafael E-mail: firstname.lastname@example.com; Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon I, 1428 Buenos Aires
Born-Infeld electromagnetic waves interacting with a static magnetic background in an expanding universe are studied. The non-linear character of Born-Infeld electrodynamics modifies the relation between the energy flux and the distance to the source, which gains a new dependence on the redshift that is governed by the background field. We compute the luminosity distance as a function of the redshift and compare with Maxwellian curves for supernovae type Ia.
Modification to the luminosity distance redshift relation in modified gravity theories
Flanagan, Eanna E.; Rosenthal, Eran; Wasserman, Ira M.
We derive an expression for the luminosity distance as a function of redshift for a flat Robertson-Walker spacetime perturbed by arbitrary scalar perturbations possibly produced by a modified gravity theory with two different scalar perturbation potentials. Measurements of the luminosity distance as function of redshift provide a constraint on a combination of the scalar potentials and so they can complement weak lensing and other measurements in trying to distinguish among the various alternative theories of gravity.
Discovering the Nature of Dark Energy: Towards Better Distances from Type
Office of Scientific and Technical Information (OSTI)
Ia Supernovae -- Final Technical Report (Technical Report) | SciTech Connect Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae -- Final Technical Report Citation Details In-Document Search Title: Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae -- Final Technical Report Type Ia supernovae (SNe Ia; exploding white-dwarf stars) were the key to the Nobel-worthy 1998 discovery and subsequent verification that the
Type IIP supernovae as cosmological probes: A SEAM distance to SN1999em
Baron, E.; Nugent, Peter E.; Branch, David; Hauschildt, Peter H.
Because of their intrinsic brightness, supernovae make excellent cosmological probes. We describe the spectral-fitting expanding atmosphere method (SEAM) for obtaining distances to Type IIP supernovae (SNe IIP) and present a distance to SN 1999em for which a Cepheid distance exists. Our models give results consistent with the Cepheid distance, even though we have not attempted to tune the underlying hydrodynamical model but have simply chosen the best fits. This is in contradistinction to the expanding photosphere method (EPM), which yields a distance to SN 1999em that is 50 percent smaller than the Cepheid distance. We emphasize the differences between the SEAM and the EPM. We show that the dilution factors used in the EPM analysis were systematically too small at later epochs. We also show that the EPM blackbody assumption is suspect. Since SNe IIP are visible to redshifts as high as z {approx}< 6, with the James Webb Space Telescope, the SEAM may be a valuable probe of the early universe.
Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)
Not Available
This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.
Beyond telecommuting: A new paradigm for the effect of telecommunications on travel
Niles, J.S.
Conventional wisdom about social and economic behavior holds that the use of telecommunications is a natural substitute for transportation. For example, telephone calls can replace travel to meetings, and facsimile or electronic-mail transmission of documents substitutes for courier or postal delivery. The moving of information can replace the moving of period and goods. Vehicle traffic on the national transportation infrastructure can be replaced by digital traffic on what is now called the National Information Infrastructure (NII). A leading example is telecommuting. This means using telecommunications to replace commuting between home and work. Telecommuting is an optional way of expanding employees` work locations in those circumstances where it yields both improved organizational performance and employee satisfication. Telecommuting accounts for 7.6 million U.S. workers as of early 1993, up 15% from the 6.6 million counted in 1992. The growth of telecommuting has been strong for the past five years. No one has identified any reasons to suggest that this growth will abate in the forseeable future.
Outside the Continental United States International Travel and Contagion Impact Quick Look Tool
Corley, Courtney D.; Lancaster, Mary J.; Brigantic, Robert T.; Kunkel, Brenda M.; Muller, George; McKenzie, Taylor K.
ABSTRACT This paper describes a tool that will allow public health analysts to estimate infectious disease risk at the country level as a function of different international transportation modes. The prototype focuses on a cholera epidemic originating within Latin America or the Caribbean, but it can be expanded to consider other pathogens as well. This effort leverages previous work in collaboration with the Centers for Disease Control and Prevention to develop the International Travel to Community Impact (IT-CI) model, which analyzes and assesses potential international disease outbreaks then estimates the associated impacts to U.S. communities and the nation as a whole and orient it for use Outside the Continental United States (OCONUS). For brevity, we refer to this refined model as OIT-CI. First, we developed an operationalized meta-population spatial cholera model for Latin America and the Caribbean at the secondary administrative-level boundary. Secondly, we developed a robust function of human airline critical to approximating mixing patterns in the meta- population model. In the prototype version currently presented here, OIT-CI models a cholera epidemic originating in a Latin American or Caribbean country and spreading via airline transportation routes. Disease spread is modeled at the country level using a patch model with a connectivity function based on demographic, geospatial, and human transportation data. We have also identified data to estimate the water and health-related infrastructure capabilities of each country to include this potential impact on disease transmission.
Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide
Ginzburg, N. S. Zaslavsky, V. Yu.; Zotova, I. V.; Sergeev, A. S.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V.
A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by "fresh" electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam.
A nonlinear analysis of the terahertz serpentine waveguide traveling-wave amplifier
Li, Ke Cao, Miaomiao; Liu, Wenxin Wang, Yong
A nonlinear model for the numerical simulation of terahertz serpentine waveguide traveling-wave tube (SW-TWT) is described. In this model, the electromagnetic wave transmission in the SW is represented as an infinite set of space harmonics to interact with an electron beam. Analytical expressions for axial electric fields in axisymmetric interaction gaps of SW-TWTs are derived and compared with the results from CST simulation. The continuous beam is treated as discrete macro-particles with different initial phases. The beam-tunnel field equations, space-charge field equations, and motion equations are combined to solve the beam-wave interaction. The influence of backward wave and relativistic effect is also considered in the series of equations. The nonlinear model is used to design a 340 GHz SW-TWT. Several favorable comparisons of model predictions with results from a 3-D Particle-in-cell simulation code CHIPIC are presented, in which the output power versus beam voltage and interaction periods are illustrated. The relative error of the predicted output power is less than 15% in the 3 dB bandwidth and the relative error of the saturated length is less than 8%.The results show that the 1-D nonlinear analysis model is appropriate to solve the terahertz SW-TWT operation characteristics.
An Ansatz Regarding Relativistic Space Travel Part II-Propulsion Realities
Murad, Paul A
Travel to the stars can involve a perilous journey in an unfriendly space-time continuum that can include singularities, nonlinear events, gravity as a function of both position and vehicle velocity, and extra dimensional effects discussed in Part I. Such a device may possibly use field propulsion technology. Although several field propulsion schemes exist, a proposed candidate is based upon using an electromagnetic drive that uses a rotating magnetic field superimposed on the spacecraft's stationary or static electric field. This is comparable to a Searl generator and the field interaction would generate an electromagnetic vortex to create nonlinear gravitational effects possibly due to an inverse Gertsenshtein relationship to push against the intrinsic gravitational field of a planet. Moreover, changing alignment of the magnetic field axis with the electric field will induce a margin of lateral controllability. Issues such as assessing this combined effect of using both electric and magnetic fields are discussed. Finally, the need for experimental data is stressed to validate these otherwise very speculative theoretical notions.
Quality analysis of the solution produced by dissection algorithms applied to the traveling salesman problem
Cesari, G.
The aim of this paper is to analyze experimentally the quality of the solution obtained with dissection algorithms applied to the geometric Traveling Salesman Problem. Starting from Karp`s results. We apply a divide and conquer strategy, first dividing the plane into subregions where we calculate optimal subtours and then merging these subtours to obtain the final tour. The analysis is restricted to problem instances where points are uniformly distributed in the unit square. For relatively small sets of cities we analyze the quality of the solution by calculating the length of the optimal tour and by comparing it with our approximate solution. When the problem instance is too large we perform an asymptotical analysis estimating the length of the optimal tour. We apply the same dissection strategy also to classical heuristics by calculating approximate subtours and by comparing the results with the average quality of the heuristic. Our main result is the estimate of the rate of convergence of the approximate solution to the optimal solution as a function of the number of dissection steps, of the criterion used for the plane division and of the quality of the subtours. We have implemented our programs on MUSIC (MUlti Signal processor system with Intelligent Communication), a Single-Program-Multiple-Data parallel computer with distributed memory developed at the ETH Zurich.
G-band harmonic multiplying gyrotron traveling-wave amplifier with a mode-selective circuit
Yeh, Y. S.; Chen, Chang-Hong; Wang, Z. W.; Kao, B. H.; Chen, Chien-Hsiang; Lin, T. Y.; Guo, Y. W.
Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) permit for magnetic field reduction and frequency multiplication. A high-order-mode harmonic multiplying gyro-TWA with large circuit dimensions and low ohmic loss can achieve a high average power. By amplifying a fundamental harmonic TE{sub 01} drive wave, the second harmonic component of the beam current initiates a TE{sub 02} wave to be amplified. Wall losses can suppress some competing modes because they act as an effective sink of the energy of the modes. However, such wall losses do not suppress all competing modes as the fields are contracted in the copper section in the gyro-TWA. An improved mode-selective circuit, using circular waveguides with the specified radii, can provide the rejection points within the frequency range to suppress the competing modes. The simulated results reveal that the mode-selective circuit can provide an attenuation of more than 10 dB to suppress the competing modes (TE{sub 21}, TE{sub 51}, TE{sub 22}, and TE{sub 03}). A G-band second harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 50 kW at 198.8 GHz, corresponding to a saturated gain of 55 dB at an interaction efficiency of 10%. The full width at half maximum bandwidth is 5 GHz.
Low-voltage harmonic multiplying gyrotron traveling-wave amplifier in G band
Yeh, Y. S.; Guo, Y. W.; Kao, B. H.; Chen, C. H.; Wang, Z. W.; Hung, C. L.; Chang, T. H.
Harmonic multiplying operation in a gyrotron traveling-wave amplifier (gyro-TWA) permits for magnetic field reduction and frequency multiplication. Lowering a beam voltage is an important step toward miniaturization of a harmonic multiplying gyro-TWA. However, the additional degree of freedom that is provided by the multitude cyclotron harmonics in a low-voltage harmonic multiplying gyro-TWA still easily generates various competing modes. An improved mode-selective circuit, using circular waveguides with various radii, can provide the rejection points within the frequency range to suppress competing modes. Simulated results reveal that the mode-selective circuit can provide an attenuation of more than 14 dB to suppress the competing modes. Furthermore, the performance of the gyro-TWA is analyzed for studying the sensitivity of the saturated output power and full width at half maximum bandwidth of the gyro-TWA to the beam voltage and the magnetic field. A stable low-voltage harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 24 kW at 200.4 GHz, corresponding to a saturated gain of 56 dB at an interaction efficiency of 20%. The full width at half maximum bandwidth is 3.0 GHz.
Estimating Traveler Populations at Airport and Cruise Terminals for Population Distribution and Dynamics
Jochem, Warren C; Sims, Kelly M; Bright, Eddie A; Urban, Marie L; Rose, Amy N; Coleman, Phil R; Bhaduri, Budhendra L
In recent years, uses of high-resolution population distribution databases are increasing steadily for environmental, socioeconomic, public health, and disaster-related research and operations. With the development of daytime population distribution, temporal resolution of such databases has been improved. However, the lack of incorporation of transitional population, namely business and leisure travelers, leaves a significant population unaccounted for within the critical infrastructure networks, such as at transportation hubs. This paper presents two general methodologies for estimating passenger populations in airport and cruise port terminals at a high temporal resolution which can be incorporated into existing population distribution models. The methodologies are geographically scalable and are based on, and demonstrate how, two different transportation hubs with disparate temporal population dynamics can be modeled utilizing publicly available databases including novel data sources of flight activity from the Internet which are updated in near-real time. The airport population estimation model shows great potential for rapid implementation for a large collection of airports on a national scale, and the results suggest reasonable accuracy in the estimated passenger traffic. By incorporating population dynamics at high temporal resolutions into population distribution models, we hope to improve the estimates of populations exposed to or at risk to disasters, thereby improving emergency planning and response, and leading to more informed policy decisions.
Is the Short Distance Scale a Result of a Problem with the LMC Photometric Zero Point?
Popowski, P
I present a promising route to harmonize distance measurements based on clump giants and RR Lyrae stars. This is achieved by comparing the brightness of these distance indicators in three environments: the solar neighborhood, Galactic bulge and Large Magellanic Cloud (LMC). As a result of harmonizing the distance scales in the solar neighborhood and Baade's Window, I derive the new absolute magnitude of RR Lyrae stars, M{sub v}(RR) at [Fe/H] = -1.6 (0.59 {+-} 0.05, 0.70 {+-} 0.05). Being somewhat brighter than the statistical parallax solution, but fainter than typical results of the main sequence fitting to Hipparcos data, these values of M{sub V}(RR) favor intermediate or old ages of globular clusters. Harmonizing the distance scales in the LMC and Baade's Window, I show that the most likely distance modulus to the LMC, {mu}{sub LMC} is in the range 18.24 - 18.44. The Hubble constant of about 70 km/s/Mpc reported by the HST Key Project is based on the assumption that the distance modulus to the LMC equals 18.50. The results presented here indicate that the Hubble Constant may be up to 12% higher. This in turn would call for a younger Universe and could result in some tension between the age of the Universe and the ages of globular clusters. I argue that the remaining uncertainty in the distance to the LMC is now a question of one, single photometric reference point rather than discrepancies between different standard candles.
Uncertainty and Sensitivity of Contaminant Travel Times from the Upgradient Nevada Test Site to the Yucca Mountain Area
J. Zhu; K. Pohlmann; J. Chapman; C. Russell; R.W.H. Carroll; D. Shafer
Yucca Mountain (YM), Nevada, has been proposed by the U.S. Department of Energy as the nation's first permanent geologic repository for spent nuclear fuel and highlevel radioactive waste. In this study, the potential for groundwater advective pathways from underground nuclear testing areas on the Nevada Test Site (NTS) to intercept the subsurface of the proposed land withdrawal area for the repository is investigated. The timeframe for advective travel and its uncertainty for possible radionuclide movement along these flow pathways is estimated as a result of effective-porosity value uncertainty for the hydrogeologic units (HGUs) along the flow paths. Furthermore, sensitivity analysis is conducted to determine the most influential HGUs on the advective radionuclide travel times from the NTS to the YM area. Groundwater pathways are obtained using the particle tracking package MODPATH and flow results from the Death Valley regional groundwater flow system (DVRFS) model developed by the U.S. Geological Survey (USGS). Effectiveporosity values for HGUs along these pathways are one of several parameters that determine possible radionuclide travel times between the NTS and proposed YM withdrawal areas. Values and uncertainties of HGU porosities are quantified through evaluation of existing site effective-porosity data and expert professional judgment and are incorporated in the model through Monte Carlo simulations to estimate mean travel times and uncertainties. The simulations are based on two steady-state flow scenarios, the pre-pumping (the initial stress period of the DVRFS model), and the 1998 pumping (assuming steady-state conditions resulting from pumping in the last stress period of the DVRFS model) scenarios for the purpose of long-term prediction and monitoring. The pumping scenario accounts for groundwater withdrawal activities in the Amargosa Desert and other areas downgradient of YM. Considering each detonation in a clustered region around Pahute Mesa (in
Traveling-wave laser-produced-plasma energy source for photoionization laser pumping and lasers incorporating said
Sher, Mark H.; Macklin, John J.; Harris, Stephen E.
A traveling-wave, laser-produced-plasma, energy source used to obtain single-pass gain saturation of a photoionization pumped laser. A cylindrical lens is used to focus a pump laser beam to a long line on a target. Grooves are cut in the target to present a surface near normal to the incident beam and to reduce the area, and hence increase the intensity and efficiency, of plasma formation.
Fall 2007 American Geophysical Union Meeting Student Travel Support for Environmental Nanomaterials Session (#B35) (December 10-14, 2007)
Michael F. Hochella, Jr.
The purpose of award no. DE-FG02-08ER15925 was to fund travel for students to present at the Fall 2007 American Geophysical Meeting. This was done successfully, and five students (Bin Xie, Qiaona Hu, Katie Schreiner, Daria Kibanova, and Frank-Andreas Weber) gave excellent oral and poster presentations at the meeting. Provided are the conference abstracts for their presentations.
Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States Planning an extended vacation or working abroad? rx_lanl_override_0311 Maintaining prescription coverage and accessing care for long-term stays abroad What you need to know about override requests and obtaining Rx drugs. Your BCBSNM prescription drug coverage limits override requests to a 90-day supply. Override requests cannot be approved - and are not available -
Estimation and validation of mode distances for the 1993 Commodity Flow Survey
Middendorf, D.P.; Bronzini, M. S.; Peterson, B.; Liu, Cheng; Chin, Shih-Miao
The 1993 Commodity Flow Survey (CFS) collected shipment data from a sample of approximately 200,000 domestic business establishments. Each selected establishment provided information on origin, destination, commodity, shipment weight and value, and modes of transport for a sample of its outbound shipments. One data item not reported by CFS participants was shipment distance. This important piece of information was estimated by simulating probable routes using computer models of the highway, rail, air, waterway, and pipeline networks and their interconnections. This paper describes the nature of the shipment distance estimation problem, the procedures used to estimate mode-specific distances between origin and destination ZIP codes, and the techniques used to validate the results.
Student Travel to Pan-Am Congress of Plants & Biofuels in Merida, Mexico
Kimberly, Kimnach
Department of Energy – Final Technical Report Grant Title: Student Travel to Pan-Am Congress of Plants & Biofuels in Merida, Mexico Award #: DE-FG02-08ER64612 Award Amount: $15,000.00 Award period: 6/15/2008 to 6/14/2009 ______________________________________________________________________________ The Pan American Congress on Plants and BioEnergy convened in Mérida, Mexico, June 22 to 25, 2008. The program was organized by Steve Long (University of Illinois) and Nick Carpita (Purdue University), along with co-organizers Marcos Buckeridge (University of São Paulo, Brazil) and Federico Sánchez (Universidad Nacional Autónoma de México). More than 200 scientists from over a dozen nations around the world gathered to discuss key issues surrounding the development of biofuel feedstocks and to report on their research in this area. This three day conference had invited speakers surrounding developing renewable and sustainable energy resources which are typically propelled by three important drivers – security, cost and environmental impact. The first day of the conference was delegated to governmental policy makers and designers of national research and plant biologists, agronomists, microbiologists, economists and ecologists in relation to bioenergy security in the Western Hemisphere that is sustainable and ecologically and economically sound. Speakers from countries that have already made themselves energy independent shared solutions to improve efficiency that is being researched. Venture capitalist and industry leaders also spoke on their commitment to economic success in a new green agroindustry. Days two and three explored bioenergy crops and introduced the participants to the breadth of the agricultural landscape, the underlying biology of bioenergy plants and new ideas to enhance biomass yield and quality of the energy crops of the future. These presentations educated the participants in an effort to develop energy strategies in countries across the
Registrations and vehicle miles of travel of light duty vehicles, 1985--1995
Hu, P.S.; Davis, S.C.; Schmoyer, R.L.
To obtain vehicle registration data that consistently and accurately reflect the distinction between automobiles and light-duty trucks, Oak Ridge National Laboratory (ORNL) was asked by FHWA to estimate the current and historical vehicle registration numbers of automobiles and of other two-axle four-tire vehicles (i.e., light-duty trucks), and their associated travel. The term automobile is synonymous with passenger car. Passenger cars are defined as all sedans, coupes, and station wagons manufactured primarily for the purpose of carrying passengers. This includes taxicabs, rental cars, and ambulances and hearses on an automobile chassis. Light-duty trucks refer to all two-axle four-tire vehicles other than passenger cars. They include pickup trucks, panel trucks, delivery and passenger vans, and other vehicles such as campers, motor homes, ambulances on a truck chassis, hearses on a truck chassis, and carryalls. In this study, light-duty trucks include four major types: (1) pickup truck, (2) van, (3) sport utility vehicle, and (4) other 2-axle 4-tire truck. Specifically, this project re-estimates statistics that appeared in Tables MV-1 and MV-9 of the 1995 Highway Statistics. Given the complexity of the approach developed in this effort and the incompleteness and inconsistency of the state-submitted data, it is recommended that alternatives be considered by FHWA to obtain vehicle registration data. One alternative is the Polk`s NVPP data (via the US Department of Transportation`s annual subscription to Polk). The second alternative is to obtain raw registration files from individual states` Departments of Motor Vehicles and to decode individual VINs.
A weak zero-one law for sequences of random distance graphs
Zhukovskii, Maksim E
We study zero-one laws for properties of random distance graphs. Properties written in a first-order language are considered. For p(N) such that pN{sup {alpha}}{yields}{infinity} as N{yields}{infinity}, and (1-p)N{sup {alpha}} {yields} {infinity} as N {yields} {infinity} for any {alpha}>0, we succeed in refuting the law. In this connection, we consider a weak zero-one j-law. For this law, we obtain results for random distance graphs which are similar to the assertions concerning the classical zero-one law for random graphs. Bibliography: 18 titles.
On chemical distances and shape theorems in percolation models with long-range correlations
Drewitz, Alexander; R�th, Bal�zs; Sapozhnikov, Art�m
In this paper, we provide general conditions on a one parameter family of random infinite subsets of Z{sup d} to contain a unique infinite connected component for which the chemical distances are comparable to the Euclidean distance. In addition, we show that these conditions also imply a shape theorem for the corresponding infinite connected component. By verifying these conditions for specific models, we obtain novel results about the structure of the infinite connected component of the vacant set of random interlacements and the level sets of the Gaussian free field. As a byproduct, we obtain alternative proofs to the corresponding results for random interlacements in the work of Cern� and Popov [�On the internal distance in the interlacement set,� Electron. J. Probab. 17(29), 1�25 (2012)], and while our main interest is in percolation models with long-range correlations, we also recover results in the spirit of the work of Antal and Pisztora [�On the chemical distance for supercritical Bernoulli percolation,� Ann Probab. 24(2), 1036�1048 (1996)] for Bernoulli percolation. Finally, as a corollary, we derive new results about the (chemical) diameter of the largest connected component in the complement of the trace of the random walk on the torus.
Long distance high power optical laser fiber break detection and continuity monitoring systems and methods
Rinzler, Charles C.; Gray, William C.; Faircloth, Brian O.; Zediker, Mark S.
A monitoring and detection system for use on high power laser systems, long distance high power laser systems and tools for performing high power laser operations. In particular, the monitoring and detection systems provide break detection and continuity protection for performing high power laser operations on, and in, remote and difficult to access locations.
Stellar metallicity of the extended disk and distance of the spiral galaxy NGC 3621
Kudritzki, Rolf-Peter; Bresolin, Fabio; Hosek, Matthew W. Jr.; Urbaneja, Miguel A.; Przybilla, Norbert E-mail: firstname.lastname@example.com E-mail: email@example.com
Low resolution (?4.5 �) ESO VLT/FORS spectra of blue supergiant stars are analyzed to determine stellar metallicities (based on elements such as iron, titanium, and magnesium) in the extended disk of the spiral galaxy, NGC 3621. Mildly subsolar metallicity (�0.30 dex) is found for the outer objects beyond 7 kpc, independent of galactocentric radius and compatible with the absence of a metallicity gradient, confirming the results of a recent investigation of interstellar medium H II region gas oxygen abundances. The stellar metallicities are slightly higher than those from the H II regions when based on measurements of the weak forbidden auroral oxygen line at 4363 � but lower than the ones obtained with the R {sub 23} strong line method. It is shown that the present level of metallicity in the extended disk cannot be the result of chemical evolution over the age of the disk with the present rate of in situ star formation. Additional mechanisms must be involved. In addition to metallicity, stellar effective temperatures, gravities, interstellar reddening, and bolometric magnitudes are determined. After the application of individual reddening corrections for each target, the flux-weighted gravity-luminosity relationship of blue supergiant stars is used to obtain a distance modulus of 29.07 � 0.09 mag (distance D = 6.52 � 0.28 Mpc). This new distance is discussed in relation to Cepheid and the tip of the red giant branch distances.
Standoff Spectroscopy Using a Conditioned Target Identifies Hazardous Materials at a Distance
A safer method for the standoff (long distance) detection and identification ofmolecules on a surface has been invented by researchers at ORNL and the Universityof Tennessee. This invention avoids the necessity of close and potentially hazardouscontact. It combines tunable infrared (IR) and ultraviolet (UV) spectroscopy techniquesto target identifying properties of surface residues....
Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platform (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)
Tremblay, Julien [DOE JGI
Julien Tremblay from DOE JGI presents "Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platorm" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.
A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila
Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; Booth, Benjamin W.; Evans-Holm, Martha; Venken, Koen J.T.; Levis, Robert W.; Spradling, Allan C.; Hoskins, Roger A.; Bellen, Hugo J.
Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstrate reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.
A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila
Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; et al
Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstratemore » reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.« less
Astrophysical tests of modified gravity: Constraints from distance indicators in the nearby universe
Jain, Bhuvnesh; Vikram, Vinu; Sakstein, Jeremy
We use distance measurements in the nearby universe to carry out new tests of gravity, surpassing other astrophysical tests by over two orders of magnitude for chameleon theories. The three nearby distance indicators�cepheids, tip of the red giant branch (TRGB) stars, and water masers�operate in gravitational fields of widely different strengths. This enables tests of scalar-tensor gravity theories because they are screened from enhanced forces to different extents. Inferred distances from cepheids and TRGB stars are altered (in opposite directions) over a range of chameleon gravity theory parameters well below the sensitivity of cosmological probes. Using published data, we have compared cepheid and TRGB distances in a sample of unscreened dwarf galaxies within 10 Mpc. We use a comparable set of screened galaxies as a control sample. We find no evidence for the order unity force enhancements expected in these theories. Using a two-parameter description of the models (the coupling strength and background field value), we obtain constraints on both the chameleon and symmetron screening scenarios. In particular we show that f(R) models with background field values f {sub R0} above 5 � 10{sup �7} are ruled out at the 95% confidence level. We also compare TRGB and maser distances to the galaxy NGC 4258 as a second test for larger field values. While there are several approximations and caveats in our study, our analysis demonstrates the power of gravity tests in the local universe. We discuss the prospects for additional improved tests with future observations.
Corridor One: An Integrated Distance Visualization Environment for SSI and ASCI Applications
Rick Stevens; Jason Leigh
Scenarios describe realistic uses of DVC/Distance technologies in several years. Four scenarios are described: Distributed Decision Making; Remote Interactive Computing; Remote Visualization: (a) Remote Immersive Visualization and (b) Remote Scientific Visualization; Remote Virtual Prototyping. Scenarios serve as drivers for the road maps and enable us to check that the functionality and technology in the road maps match application needs. There are four major DVC/Distance technology areas we cover: Networking and QoS; Remote Computing; Remote Visualization; Remote Data. Each �??road map�?� consists of two parts, a �??functionality�?� matrix (what can be done) and a �??technology�?� matrix (underlying technology). That is, functionality matrices show the desired operational characteristics, while technology matrices show the underlying technology needed. In practice, there isn�??t always a clean break between �??functionality�?� and �??technology,�?� but it still seems useful to try and separate things this way.
Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern
El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M.; Hosny, K.A.; Esmat, G.; Abdelaziz, A.I.
Highlights: �The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. �E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. �miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. �miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. �miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.
INL and NREL Demonstrate Power Grid Simulation at a Distance - News
U.S. Department of Energy (DOE) - all webpages (Extended Search)
Releases | NREL INL and NREL Demonstrate Power Grid Simulation at a Distance Capability makes national laboratory assets accessible to grid researchers worldwide May 4, 2015 The Energy Department's National Renewable Energy Laboratory (NREL) and Idaho National Laboratory (INL) have successfully demonstrated the capability to connect grid simulations at their two labs for real time interaction via the Internet. This new inter-lab capability enables the modeling of power grids in greater
Optical fiber configurations for transmission of laser energy over great distances
Rinzler, Charles C; Zediker, Mark S
There are provided optical fiber configurations that provide for the delivery of laser energy, and in particular, the transmission and delivery of high power laser energy over great distances. These configurations further are hardened to protect the optical fibers from the stresses and conditions of an intended application. The configurations provide means for determining the additional fiber length (AFL) need to obtain the benefits of such additional fiber, while avoiding bending losses.
Optical fiber configurations for transmission of laser energy over great distances
Rinzler, Charles C; Zediker, Mark S
There are provided optical fiber configurations that provide for the delivery of laser energy, and in particular, the transmission and delivery of high power laser energy over great distances. These configurations further are hardened to protect the optical fibers from the stresses and conditions of an intended application. The configurations provide means for determining the additional fiber length (AFL) need to obtain the benefits of such additional fiber, while avoiding bending losses.
IDENTIFYING THE YOUNG LOW-MASS STARS WITHIN 25 pc. II. DISTANCES, KINEMATICS, AND GROUP MEMBERSHIP
Shkolnik, Evgenya L.; Anglada-Escude, Guillem; Liu, Michael C.; Bowler, Brendan P.; Weinberger, Alycia J.; Boss, Alan P.; Reid, I. Neill; Tamura, Motohide
We have conducted a kinematic study of 165 young M dwarfs with ages of {approx}<300 Myr. Our sample is composed of stars and brown dwarfs with spectral types ranging from K7 to L0, detected by ROSAT and with photometric distances of {approx}<25 pc assuming that the stars are single and on the main sequence. In order to find stars kinematically linked to known young moving groups (YMGs), we measured radial velocities for the complete sample with Keck and CFHT optical spectroscopy and trigonometric parallaxes for 75 of the M dwarfs with the CAPSCam instrument on the du Pont 2.5 m Telescope. Due to their youthful overluminosity and unresolved binarity, the original photometric distances for our sample underestimated the distances by 70% on average, excluding two extremely young ({approx}<3 Myr) objects found to have distances beyond a few hundred parsecs. We searched for kinematic matches to 14 reported YMGs and identified 10 new members of the AB Dor YMG and 2 of the Ursa Majoris group. Additional possible candidates include six Castor, four Ursa Majoris, two AB Dor members, and one member each of the Her-Lyr and {beta} Pic groups. Our sample also contains 27 young low-mass stars and 4 brown dwarfs with ages {approx}<150 Myr that are not associated with any known YMG. We identified an additional 15 stars that are kinematic matches to one of the YMGs, but the ages from spectroscopic diagnostics and/or the positions on the sky do not match. These warn against grouping stars together based only on kinematics and that a confluence of evidence is required to claim that a group of stars originated from the same star-forming event.
Vargas Alvarez, Carlos A.; Kobulnicky, Henry A.; Bradley, David R.; Kannappan, Sheila J.; Norris, Mark A.; Cool, Richard J.; Miller, Brendan P. E-mail: email@example.com E-mail: email@example.com E-mail: email@example.com
We present a spectroscopic and photometric determination of the distance to the young Galactic open cluster Westerlund 2 using WFPC2 imaging from the Hubble Space Telescope (HST) and ground-based optical spectroscopy. HST imaging in the F336W, F439W, F555W, and F814W filters resolved many sources previously undetected in ground-based observations and yielded photometry for 1136 stars. We identified 15 new O-type stars, along with two probable binary systems, including MSP 188 (O3 + O5.5). We fit reddened spectral energy distributions based on the Padova isochrones to the photometric data to determine individual reddening parameters R{sub V} and A{sub V} for O-type stars in Wd2. We find average values (R{sub V} ) = 3.77 {+-} 0.09 and (A{sub V} ) = 6.51 {+-} 0.38 mag, which result in a smaller distance than most other spectroscopic and photometric studies. After a statistical distance correction accounting for close unresolved binaries (factor of 1.08), our spectroscopic and photometric data on 29 O-type stars yield that Westerlund 2 has a distance (d) = 4.16 {+-} 0.07 (random) +0.26 (systematic) kpc. The cluster's age remains poorly constrained, with an upper limit of 3 Myr. Finally, we report evidence of a faint mid-IR polycyclic aromatic hydrocarbon ring surrounding the well-known binary candidate MSP 18, which appears to lie at the center of a secondary stellar grouping within Westerlund 2.
Resonances in Coupled Scattering from Quantum Chromodynamics
Dudek, Jozef J.; Edwards, Robert G.; Thomas, Christopher E.; Wilson, David J.
Using first-principles calculation within Quantum Chromodynamics, we are able to reproduce the pattern of experimental strange resonances which appear as complex singularities within coupled πK, ηK scattering amplitudes. We make use of numerical computation within the lattice discretized approach to QCD, extracting the energy dependence of scattering amplitudes through their relation- ship to the discrete spectrum of the theory in a finite-volume, which we map out in unprecedented detail.
Minimum separation distances for natural gas pipeline and boilers in the 300 area, Hanford Site
Daling, P.M.; Graham, T.M.
The U.S. Department of Energy (DOE) is proposing actions to reduce energy expenditures and improve energy system reliability at the 300 Area of the Hanford Site. These actions include replacing the centralized heating system with heating units for individual buildings or groups of buildings, constructing a new natural gas distribution system to provide a fuel source for many of these units, and constructing a central control building to operate and maintain the system. The individual heating units will include steam boilers that are to be housed in individual annex buildings located at some distance away from nearby 300 Area nuclear facilities. This analysis develops the basis for siting the package boilers and natural gas distribution systems to be used to supply steam to 300 Area nuclear facilities. The effects of four potential fire and explosion scenarios involving the boiler and natural gas pipeline were quantified to determine minimum separation distances that would reduce the risks to nearby nuclear facilities. The resulting minimum separation distances are shown in Table ES.1.
After 1970 Transuranic (TRU) and suspect TRU waste was buried in the ground with the intention that at some later date the waste would be retrieved and processed into a configuration for long term storage. To retrieve this waste the soil must be removed (excavated). Sloping the bank of the excavation is the method used to keep the excavation from collapsing and to provide protection for workers retrieving the waste. The purpose of this paper is to document the minimum distance (setback) that equipment must stay from the edge of the excavation to maintain a stable slope. This evaluation examines the equipment setback distance by dividing the equipment into two categories, (1) equipment used for excavation and (2) equipment used for retrieval. The section on excavation equipment will also discuss techniques used for excavation including the process of benching. Calculations 122633-C-004, 'Slope Stability Analysis' (Attachment A), and 300013-C-001, 'Crane Stability Analysis' (Attachment B), have been prepared to support this evaluation. As shown in the calculations the soil has the following properties: Unit weight 110 pounds per cubic foot; and Friction Angle (natural angle of repose) 38{sup o} or 1.28 horizontal to 1 vertical. Setback distances are measured from the top edge of the slope to the wheels/tracks of the vehicles and heavy equipment being utilized. The computer program utilized in the calculation uses the center of the wheel or track load for the analysis and this difference is accounted for in this evaluation.
Distance-dependent plasma composition and ion energy in high power impulse magnetron sputtering
Ehiasarian, Arutiun P; Andersson, Joakim; Anders, Andr�
The plasma composition of high power impulse magnetron sputtering (HIPIMS) has been studied for titanium and chromium targets using a combined energy analyser and quadrupole mass spectrometer. Measurements were done at distances from 50 to 300 mm from the sputtering target. Ti and Cr are similar in atomic mass but have significantly different sputter yields, which gives interesting clues on the effect of the target on plasma generation and transport of atoms. The Ti and Cr HIPIMS plasmas operated at a peak target current density of ~;;0.5 A cm-2. The measurements of the argon and metal ion content as well as the ion energy distribution functions showed that (1) singly and doubly charged ions were found for argon as well as for the target metal, (2) the majority of ions were singly charged argon for both metals at all distances investigated, (3) the Cr ion density was maintained to distances further from the target than Ti. Gas rarefaction was identified as a main factor promoting transport of metal ions, with the stronger effect observed for Cr, the material with higher sputter yield. Cr ions were found to displace a significant portion of the gas ions, whereas this was less evident in the Ti case. The observations indicate that the presence of metal vapour promotes charge exchange and reduces the electron temperature and thereby practically prevents the production of Ar2+ ions near the target. The content of higher charge states of metal ions depends on the probability of charge exchange with argon.
Using red clump stars to decompose the galactic magnetic field with distance
Pavel, Michael D.
A new method for measuring the large-scale structure of the Galactic magnetic field is presented. The Galactic magnetic field has been probed through the Galactic disk with near-infrared starlight polarimetry; however, the distance to each background star is unknown. Using red clump stars as near-infrared standard candles, this work presents the first attempt to decompose the line-of-sight structure of the sky-projected Galactic magnetic field. Two example lines of sight are decomposed: toward a field with many red clump stars and toward a field with few red clump stars. A continuous estimate of magnetic field orientation over several kiloparsecs of distance is possible in the field with many red clump stars, while only discrete estimates are possible in the sparse example. Toward the outer Galaxy, there is a continuous field orientation with distance that shows evidence of perturbation by the Galactic warp. Toward the inner Galaxy, evidence for a large-scale change in the magnetic field geometry is consistent with models of magnetic field reversals, independently derived from Faraday rotation studies. A photo-polarimetric method for identifying candidate intrinsically polarized stars is also presented. The future application of this method to large regions of the sky will begin the process of mapping the Galactic magnetic field in a way never before possible.
Moving Large Data Sets Over High-Performance Long Distance Networks
Hodson, Stephen W; Poole, Stephen W; Ruwart, Thomas; Settlemyer, Bradley W
In this project we look at the performance characteristics of three tools used to move large data sets over dedicated long distance networking infrastructure. Although performance studies of wide area networks have been a frequent topic of interest, performance analyses have tended to focus on network latency characteristics and peak throughput using network traffic generators. In this study we instead perform an end-to-end long distance networking analysis that includes reading large data sets from a source file system and committing large data sets to a destination file system. An evaluation of end-to-end data movement is also an evaluation of the system configurations employed and the tools used to move the data. For this paper, we have built several storage platforms and connected them with a high performance long distance network configuration. We use these systems to analyze the capabilities of three data movement tools: BBcp, GridFTP, and XDD. Our studies demonstrate that existing data movement tools do not provide efficient performance levels or exercise the storage devices in their highest performance modes. We describe the device information required to achieve high levels of I/O performance and discuss how this data is applicable in use cases beyond data movement performance.
Long-distance entanglement and quantum teleportation in XX spin chains
Campos Venuti, L.; Giampaolo, S. M.; Illuminati, F.; Zanardi, P.
Isotropic XX models of one-dimensional spin-1/2 chains are investigated with the aim to elucidate the formal structure and the physical properties that allow these systems to act as channels for long-distance, high-fidelity quantum teleportation. We introduce two types of models: (i) open, dimerized XX chains, and (ii) open XX chains with small end bonds. For both models we obtain the exact expressions for the end-to-end correlations and the scaling of the energy gap with the length of the chain. We determine the end-to-end concurrence and show that model (i) supports true long-distance entanglement at zero temperature, while model (ii) supports 'quasi-long-distance' entanglement that slowly falls off with the size of the chain. Due to the different scalings of the gaps, respectively exponential for model (i) and algebraic in model (ii), we demonstrate that the latter allows for efficient qubit teleportation with high fidelity in sufficiently long chains even at moderately low temperatures.
Infrared tip of the red giant branch and distances to the MAFFEI/IC 342 group
Wu, Po-Feng; Tully, R. Brent; Jacobs, Bradley A.; Rizzi, Luca; Dolphin, Andrew E.; Karachentsev, Igor D.
In this paper, we extend the use of the tip of the red giant branch (TRGB) method to near-infrared wavelengths from the previously used I-band, using the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3). Upon calibration of a color dependency of the TRGB magnitude, the IR TRGB yields a random uncertainty of ∼5% in relative distance. The IR TRGB methodology has an advantage over the previously used Advance Camera for Surveys F606W and F814W filter set for galaxies that suffer from severe extinction. Using the IR TRGB methodology, we obtain distances toward three principal galaxies in the Maffei/IC 342 complex, which are located at low Galactic latitudes. New distance estimates using the TRGB method are 3.45{sub −0.13}{sup +0.13} Mpc for IC 342, 3.37{sub −0.23}{sup +0.32} Mpc for Maffei 1, and 3.52{sub −0.30}{sup +0.32} Mpc for Maffei 2. The uncertainties are dominated by uncertain extinction, especially for Maffei 1 and Maffei 2. Our IR calibration demonstrates the viability of the TRGB methodology for observations with the James Webb Space Telescope.
Franca, Fabio La; Bianchi, Stefano; Branchini, Enzo; Matt, Giorgio [Dipartimento di Matematica e Fisica, Universit� Roma Tre, Via della Vasca Navale 84, I-00146, Roma (Italy); Ponti, Gabriele, E-mail: email@example.com [Max-Planck-Institut f�r Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching bei M�nchen (Germany)
We report the discovery of a luminosity distance estimator using active galactic nuclei (AGNs). We combine the correlation between the X-ray variability amplitude and the black hole (BH) mass with the single-epoch spectra BH mass estimates which depend on the AGN luminosity and the line width emitted by the broad-line region. We demonstrate that significant correlations do exist that allow one to predict the AGN (optical or X-ray) luminosity as a function of the AGN X-ray variability and either the H? or the Pa? line widths. In the best case, when the Pa? is used, the relationship has an intrinsic dispersion of ?0.6�dex. Although intrinsically more disperse than supernovae Ia, this relation constitutes an alternative distance indicator potentially able to probe, in an independent way, the expansion history of the universe. With respect to this, we show that the new mission concept Athena should be able to measure the X-ray variability of hundreds of AGNs and then constrain the distance modulus with uncertainties of 0.1�mag up to z ? 0.6. We also discuss how our estimator has the prospect of becoming a cosmological probe even more sensitive than the current supernovae Ia samples by using a new dedicated wide-field X-ray telescope able to measure the variability of thousands of AGNs.
THE MEGAMASER COSMOLOGY PROJECT. V. AN ANGULAR-DIAMETER DISTANCE TO NGC 6264 AT 140 Mpc
Kuo, C. Y.; Braatz, J. A.; Lo, K. Y.; Condon, J. J.; Impellizzeri, C. M. V.; Reid, M. J.; Henkel, C.
We present the direct measurement of the Hubble constant, yielding the direct measurement of the angular-diameter distance to NGC 6264 using the H{sub 2}O megamaser technique. Our measurement is based on sensitive observations of the circumnuclear megamaser disk from four observations with the Very Long Baseline Array, the Green Bank Telescope (GBT), and the Effelsberg telescope. We also monitored the maser spectral profile for 2.3 years using the GBT to measure accelerations of maser lines by tracking their line-of-sight velocities as they change with time. The measured accelerations suggest that the systemic maser spots have a significantly wider radial distribution than in the archetypal megamaser in NGC 4258. We model the maser emission as arising from a circumnuclear disk with orbits dominated by the central black hole. The best fit of the data gives a Hubble constant of H{sub 0} = 68 {+-} 9 km s{sup -1} Mpc{sup -1}, which corresponds to an angular-diameter distance of 144 {+-} 19 Mpc. In addition, the fit also gives a mass of the central black hole of (3.09 {+-} 0.42) Multiplication-Sign 10{sup 7} M{sub Sun }. The result demonstrates the feasibility of measuring distances to galaxies located well into the Hubble flow by using circumnuclear megamaser disks.
Transportation Energy Futures Series. Effects of Travel Reduction and Efficient Driving on Transportation. Energy Use and Greenhouse Gas Emissions
Porter, C. D.; Brown, A.; DeFlorio, J.; McKenzie, E.; Tao, W.; Vimmerstedt, L.
Since the 1970s, numerous transportation strategies have been formulated to change the behavior of drivers or travelers by reducing trips, shifting travel to more efficient modes, or improving the efficiency of existing modes. This report summarizes findings documented in existing literature to identify strategies with the greatest potential impact. The estimated effects of implementing the most significant and aggressive individual driver behavior modification strategies range from less than 1% to a few percent reduction in transportation energy use and GHG emissions. Combined strategies result in reductions of 7% to 15% by 2030. Pricing, ridesharing, eco-driving, and speed limit reduction/enforcement strategies are widely judged to have the greatest estimated potential effect, but lack the widespread public acceptance needed to accomplish maximum results. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.
Transportation Energy Futures Series: Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions
Porter, C. D.; Brown, A.; DeFlorio, J.; McKenzie, E.; Tao, W.; Vimmerstedt, L.
Since the 1970s, numerous transportation strategies have been formulated to change the behavior of drivers or travelers by reducing trips, shifting travel to more efficient modes, or improving the efficiency of existing modes. This report summarizes findings documented in existing literature to identify strategies with the greatest potential impact. The estimated effects of implementing the most significant and aggressive individual driver behavior modification strategies range from less than 1% to a few percent reduction in transportation energy use and GHG emissions. Combined strategies result in reductions of 7% to 15% by 2030. Pricing, ridesharing, eco-driving, and speed limit reduction/enforcement strategies are widely judged to have the greatest estimated potential effect, but lack the widespread public acceptance needed to accomplish maximum results. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.
Design and microwave test of an ultrawideband input/output structure for sheet beam travelling wave tubes
Shu, Guoxiang; Wang, Jianxun; Liu, Guo; Yang, Liya; Luo, Yong; Wang, Shafei
Broadband operation is of great importance for the applications of travelling wave tubes such as high-data communication and wideband radar. An input/output (I/O) structure operating with broadband property plays a significant role to achieve these applications. In this paper, a Y-type branch waveguide (YTBW) coupler and its improvements are proposed and utilized to construct an extremely wideband I/O structure to ensure the broadband operation for sheet beam travelling wave tubes (SB-TWTs). Cascaded reflection resonators are utilized to improve the isolation characteristic and transmission efficiency. Furthermore, to minimize the reflectivity of the port connected with the RF circuit, wave-absorbing material (WAM) is loaded in the resonator. Simulation results for the YTBW loaded with WAM predict an excellent performance with a 50.2% relative bandwidth for port reflectivity under −15 dB, transmission up to −1.5 dB, and meanwhile isolation under −20 dB. In addition, the coupler has a relatively compact configuration and the beam tunnel can be widened, which is beneficial for the propagation of the electrons. A Q-band YTBW loaded with two reflection resonators is fabricated and microwave tested. Vector network analyzer (VNA) measured results have an excellent agreement with our simulation, which verify our theoretical analysis and simulation calculation.
Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution
Wu, Meiye; Singh, Anup K.
In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell's physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.
Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution
Wu, Meiye; Singh, Anup K.
Cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, andmore��flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell�s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.��less
Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution
Wu, Meiye; Singh, Anup K.
In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR formore » nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell's physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.« less
Wilson, R. E.; Chochol, D.; KomzIk, R.; Van Hamme, W.; Pribulla, T.; Volkov, I.
V1197 Orionis light curves from a long-term observing program for red giant binaries show ellipsoidal variation of small amplitude in the V and R{sub C} bands, although not clearly in U and B. Eclipses are not detected. All four bands show large irregular intrinsic variations, including fleeting quasi-periodicities identified by power spectra, that degrade analysis and may be caused by dynamical tides generated by orbital eccentricity. To deal with the absence of eclipses and consequent lack of astrophysical and geometrical information, direct use is made of the Hipparcos parallax distance while the V and R{sub C} light curves and (older) radial velocity curves are analyzed simultaneously in terms of absolute flux. The red giant's temperature is estimated from new spectra. This type of analysis, called Inverse Distance Estimation for brevity, is new and can also be applied to other ellipsoidal variables. Advantages gained by utilization of definite distance and temperature are discussed in regard to how radius, fractional lobe filling, and mass ratio information are expressed in the observations. The advantages were tested in solutions of noisy synthetic data. Also discussed and tested by simulations are ideas on the optimal number of light curves to be solved simultaneously under various conditions. The dim companion has not been observed or discussed in the literature but most solutions find its mass to be well below that of the red giant. Solutions show red giant masses that are too low for evolution to the red giant stage within the age of the Galaxy, although that result is probably an artifact of the intrinsic brightness fluctuations.
Low-Energy Nuclear Reactions of Protons in Host Metals at Picometre Distance
Heinrich Hora; George H. Miley; Jak C. Kelly
A review is given for the explanation of the measurements of Miley et al. of a fully reproducible generation of nuclei of the whole periodic table by protons in host metals during a several-weeks reaction. Similar low-energy nuclear reactions (LENR) were observed by other groups. The fact that the heavy nuclides are not due to pollution can be seen from the fact that such very rare elements as thulium and terbium were detected by unique K-shell X-ray spectra. The nuclear reaction energy goes into the heavy nuclei as measured from much bigger traces in CR39 than from alphas. The fact that any reaction of the protons results in stable daughter nuclei is confirmed by the fact that the highest energy gain is resulting with stable reaction products. This has been explained in Ref. 2, and the energy gain for the heavy element generation by a compound reaction was discussed. The explanation is based on the model of the authors from 1989 to assume free motion of the protons contrary to localized crystalline states. A relation of the reaction time U on distance d of the reacting nuclei by a power law with an exponent 34.8 was derived. Based on few reproducible D-D reactions, a reaction time near the range of megaseconds and a reaction distance of nanometers was concluded. A splendid confirmation of the picometre-megasecond reactions was achieved by Li et al. from his direct quantum mechanical calculations of the hot fusion D-T reactions based on a one-step selective resonance tunneling model. Li et al. were able for the first time to derive the cross sections of the hot fusion. Li's application to picometre distance showed megasecond reaction times with no neutron or gamma emission. Because of the imaginary part in the Schroedinger potential, the problem of the level width is reduced by damping.
The design, construction, and operation of long-distance high-voltage electricity transmission technologies.
Molburg, J. C.; Kavicky, J. A.; Picel, K. C.
This report focuses on transmission lines, which operate at voltages of 115 kV and higher. Currently, the highest voltage lines comprising the North American power grid are at 765 kV. The grid is the network of transmission lines that interconnect most large power plants on the North American continent. One transmission line at this high voltage was built near Chicago as part of the interconnection for three large nuclear power plants southwest of the city. Lines at this voltage also serve markets in New York and New England, also very high demand regions. The large power transfers along the West Coast are generally at 230 or 500 kV. Just as there are practical limits to centralization of power production, there are practical limits to increasing line voltage. As voltage increases, the height of the supporting towers, the size of the insulators, the distance between conductors on a tower, and even the width of the right-of-way (ROW) required increase. These design features safely isolate the electric power, which has an increasing tendency to arc to ground as the voltage (or electrical potential) increases. In addition, very high voltages (345 kV and above) are subject to corona losses. These losses are a result of ionization of the atmosphere, and can amount to several megawatts of wasted power. Furthermore, they are a local nuisance to radio transmission and can produce a noticeable hum. Centralized power production has advantages of economies of scale and special resource availability (for instance, hydro resources), but centralized power requires long-distance transfers of power both to reach customers and to provide interconnections for reliability. Long distances are most economically served at high voltages, which require large-scale equipment and impose a substantial footprint on the corridors through which power passes. The most visible components of the transmission system are the conductors that provide paths for the power and the towers that keep these
3D ARGUS-ESP computations of vacuum eigenmodes for standing-wave and traveling-wave structures
Petillo, J.J.; Chernin, D.P.; Mondelli, A.A.
The ARGUS-ESP code has been used to calculate electromagnetic vacuum eigenmodes, including dispersion diagrams, for both standing-wave and traveling-wave devices. Slow-wave structures, as used in microwave devices, are readily modeled with this code. ARGUS-ESP gives the designer the ability to do Numerical Cold Testing. For this presentation, the ARGUS electromagnetic eigenmode solver, ESP, is featured. This solver gives the user the capability to calculate cavity modes for general, arbitrarily-complicated, structures. The eigenmode solver uses a fraction of the CPU time that a time-domain calculation would take, and yields a much higher accuracy of solution. In particular, this rapid frequency domain algorithm has incorporated in it a phase-advance boundary condition that allows dispersion diagrams for devices to be readily determined, where only a single period of a structure needs to be gridded. Two examples of the application of this solver will be presented.
Very large radiative transfer over small distances from a black body for thermophotovoltaic applications
Pan, J.L.; Choy, H.K.H.; Fonstad, C.G. Jr.
The maximum amount of radiated heat intensity which can be transferred from a black body of refractive index n{sub BB} to an object of refractive index n{sub OBJ} located a short distance away is shown to be n{sup 2}{sub smaller} times the free space Planck distribution, where n{sub smaller} is the smaller of n{sub BB} and n{sub OBJ}, and where n{sub BB} and n{sub OBJ} are assumed greater than unity. The implication is that the radiative power spectral density within a thermophotovoltaic cell could be designed to be much greater than the free space Planck distribution. The maximum radiative intensity transferred occurs when the index of the black body matches that of the object at wavelengths where the Planck distribution is sizeable. A simple expression is found for the transferred radiative intensity as a function of the refractive indices of, and the distance separating, the black body and the object. The expression is interpreted in terms of the specific black body modes which are evanescent in the space between the black body and the object and which make the largest contribution to the transmission of radiation. The black body, the object, and the gap region are all modeled as lossless dielectrics.
Identifying fly ash at a distance from fossil fuel power stations
Flanders, P.J.
A method has been developed to identify fly ash originating at fossil fuel power stations, even at a distance where the ash level is lower by a factor of 1000 from that close to a source. Until now such detection has been difficult and uncertain. The technique combines collection of particles, measurement of magnetization and coercive field, and microscopy. The analysis depends on the fact that ash from iron sulfide in fossil fuels is in the form of spherical magnetite. These particles have a relatively high coercive field H{sub c}, near 135 Oe, compared with airborne particulates from soil erosion which have an H{sub c} of {approximately}35 Oe. The coercive field of any sample therefore gives an indication for the percentage of fly ash relative to the total amount of magnetic material that is airborne. The concentration of ash from a large, isolated coal burning power station is found to fall off with the distance from the source, approximately as D{sup {minus}1}. As D increases there is a drop in H{sub c}, associated with the reduced amount of fly ash relative to the airborne particulates from soil erosion.
Generalized correlation integral vectors: A distance concept for chaotic dynamical systems
Haario, Heikki; Kalachev, Leonid; Hakkarainen, Janne
Several concepts of fractal dimension have been developed to characterise properties of attractors of chaotic dynamical systems. Numerical approximations of them must be calculated by finite samples of simulated trajectories. In principle, the quantities should not depend on the choice of the trajectory, as long as it provides properly distributed samples of the underlying attractor. In practice, however, the trajectories are sensitive with respect to varying initial values, small changes of the model parameters, to the choice of a solver, numeric tolerances, etc. The purpose of this paper is to present a statistically sound approach to quantify this variability. We modify the concept of correlation integral to produce a vector that summarises the variability at all selected scales. The distribution of this stochastic vector can be estimated, and it provides a statistical distance concept between trajectories. Here, we demonstrate the use of the distance for the purpose of estimating model parameters of a chaotic dynamic model. The methodology is illustrated using computational examples for the Lorenz 63 and Lorenz 95 systems, together with a framework for Markov chain Monte Carlo sampling to produce posterior distributions of model parameters.
Dynamic Rotor Deformation and Vibration Monitoring Using a Non-Incremental Laser Doppler Distance Sensor
Pfister, Thorsten; Guenther, Philipp; Dreier, Florian; Czarske, Juergen
Monitoring rotor deformations and vibrations dynamically is an important task for improving the safety and the lifetime as well as the energy efficiency of motors and turbo machines. However, due to the high rotor speed encountered in particular at turbo machines, this requires concurrently a high measurement rate and high accuracy, which can not be fulfilled by most commercially available sensors. To solve this problem, we developed a non-incremental laser Doppler distance sensor (LDDS), which is able to measure simultaneously the in-plane velocity and the out-of-plane position of moving rough solid objects with micrometer precision. In addition, this sensor concurrently offers a high temporal resolution in the microsecond range, because its position uncertainty is in principle independent of the object velocity in contrast to conventional distance sensors, which is a unique feature of the LDDS. Consequently, this novel sensor enables precise and dynamic in-process deformation and vibration measurements on rotating objects, such as turbo machine rotors, even at very high speed. In order to evidence the capability of the LDDS, measurements of rotor deformations (radial expansion), vibrations and wobbling motions are presented at up to 50,000 rpm rotor speed.
Parametric study on maximum transportable distance and cost for thermal energy transportation using various coolants
Su-Jong Yoon; Piyush Sabharwall
The operation temperature of advanced nuclear reactors is generally higher than commercial light water reactors and thermal energy from advanced nuclear reactor can be used for various purposes such as district heating, desalination, hydrogen production and other process heat applications, etc. The process heat industry/facilities will be located outside the nuclear island due to safety measures. This thermal energy from the reactor has to be transported a fair distance. In this study, analytical analysis was conducted to identify the maximum distance that thermal energy could be transported using various coolants such as molten-salts, helium and water by varying the pipe diameter and mass flow rate. The cost required to transport each coolant was also analyzed. The coolants analyzed are molten salts (such as: KClMgCl2, LiF-NaF-KF (FLiNaK) and KF-ZrF4), helium and water. Fluoride salts are superior because of better heat transport characteristics but chloride salts are most economical for higher temperature transportation purposes. For lower temperature water is a possible alternative when compared with He, because low pressure He requires higher pumping power which makes the process very inefficient and economically not viable for both low and high temperature application.
Preliminary Measurement of Neutrino Oscillation Parameters By NuMI/MINOS and Calibration Studies for Improving this Measurement
Symes, Philip Andrew
This thesis explains the origins of neutrinos and their interactions, and the phenomenon of neutrino oscillations. Experiments for measuring neutrino oscillations are mentioned and the experiment investigated in this thesis, the ''Main Injector Neutrino Oscillation Search'', and its neutrino beam, the Fermi National Accelerator Laboratory's ''Neutrinos At The Main Injector'', are described. MINOS is a long baseline (735 km) neutrino oscillation experiment with a near and a far detector, intended to make precision measurements of the atmospheric sector neutrino oscillation parameters. A measurement is made of the ''atmospheric'' neutrino oscillation parameters, Δm$2\\atop{23}$ and sin2(2θ23), using neutrinos from the NuMI beam. The results of this analysis are compared to measurements at MINOS using neutrinos from the atmosphere and with other experiments. A more detailed method of beam neutrino analysis is discussed, and the extra calibrations needed to perform that analysis properly are described, with special attention paid to two aspects of the calibration, which comprise the bulk of work for this thesis. The light injection calibration system uses LEDs to illuminate the detector readout and provides a normalization of the stability of the detector over time. The hardware and different modi operandi of the system are described. There is a description of installation and commissioning of the system at one of the MINOS detectors. The response normalization of each detector with cosmic ray muons is described. Special attention is paid to the explanation of necessary corrections that must be made to the muon sample in order for the sample to be used to calibrate each detector to the specified accuracy. The performance of the calibration is shown.
Approach to Recover Hydrocarbons from Currently Off-Limit Areas of the Antrim Formation, MI Using Low-Impact Technologies
James Wood; William Quinlan
The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.
Observation of Electron Neutrino Appearance in the NuMI Beam with the NOvA Experiment
Niner, Evan David
NOvA is a long-baseline neutrino oscillation experiment that uses two functionally identical detectors separated by 810 kilometers at locations 14 milliradians off-axis from the NuMI muon neutrino beam at Fermilab. At these locations the beam energy peaks at 2 GeV. This baseline is the longest in the world for an accelerator-based neutrino oscillation experiment, which enhances the sensitivity to the neutrino mass ordering. The experiment studies oscillations of the muon neutrino and anti-neutrino beam that is produced. Both detectors completed commissioning in the summer of 2014 and continue to collect data. One of the primary physics goals of the experiment is the measurement of electron neutrino appearance in the muon neutrino beam which yields measurements of the oscillation parameters sin22θ13, δ , and the neutrino mass ordering within the standard model of neutrino oscillations. This thesis presents the analysis of data collected between February 2014 and May 2015, corresponding to 3.52 X 1020 protons-on-target. In this first analysis NOvA recorded 6 electron neutrino candidates, which is a 3.3σ observation of electron neutrino appearance. The T2K experiment performs the same measurement on a baseline of 295 kilometers and has a 1 σ preference for the normal mass ordering over the inverted ordering over the phase space of the CP violating parameter δ, which is also weakly seen in the NOvA result. By the summer of 2016 NOvA will triple its statistics due to increased beam power and a completed detector. If electron neutrinos continue to be observed at the current rate NOvA will be able to establish a mass ordering preference at a similar confidence level to T2K.
Maglev vehicles and superconductor technology: Integration of high-speed ground transportation into the air travel system
Johnson, L.R.; Rote, D.M.; Hull, J.R.; Coffey, H.T.; Daley, J.G.; Giese, R.F.
This study was undertaken to (1) evaluate the potential contribution of high-temperature superconductors (HTSCs) to the technical and economic feasibility of magnetically levitated (maglev) vehicles, (2) determine the status of maglev transportation research in the United States and abroad, (3) identify the likelihood of a significant transportation market for high-speed maglev vehicles, and (4) provide a preliminary assessment of the potential energy and economic benefits of maglev systems. HTSCs should be considered as an enhancing, rather than an enabling, development for maglev transportation because they should improve reliability and reduce energy and maintenance costs. Superconducting maglev transportation technologies were developed in the United States in the late 1960s and early 1970s. Federal support was withdrawn in 1975, but major maglev transportation programs were continued in Japan and West Germany, where full-scale prototypes now carry passengers at speeds of 250 mi/h in demonstration runs. Maglev systems are generally viewed as very-high-speed train systems, but this study shows that the potential market for maglev technology as a train system, e.g., from one downtown to another, is limited. Rather, aircraft and maglev vehicles should be seen as complementing rather than competing transportation systems. If maglev systems were integrated into major hub airport operations, they could become economical in many relatively high-density US corridors. Air traffic congestion and associated noise and pollutant emissions around airports would also be reduced. 68 refs., 26 figs., 16 tabs.
Effective interactions and long distance symmetries in the Nucleon-Nucleon system
Ruiz Arriola, E.; Calle Cordon, A.
Effective interactions, when defined in a coarse grained sense, such as V{sub lowk} at the scale {Lambda} = 450 MeV, display a remarkable symmetry pattern. Serber symmetry works with high accuracy for spin triplet states. Wigner SU(4) spin-isospin symmetry with nucleons in the fundamental representation works only for even partial waves exactly as predicted by large N{sub c} limit of QCD with accuracy O(1/N{sub c}{sup 2}). This suggests tailoring the very definition of effective interactions to provide a best possible fulfillment of long distance symmetries. With the V{sub lowk} definition Wigner symmetry requires that chiral potentials have low cut-offs {Lambda}{sub {chi}{approx}4}50 MeV. Perturbative saturation of exchanged heavy mesonic resonances does not faithfully display the Serber symmetry pattern.
Investigation of the EAS Lateral Particle Density at 500 m Distance from Shower Core
Toma, G.
For the experimental conditions of the KASCADE-Grande experiment, the density of EAS charged particles at the distance of about 500 m from the shower core S(500) has been shown by detailed simulation studies to be an approximate energy estimator, being nearly independent of the mass of the primary particle. This report presents some experimentally observed features of the S(500) observable registered with the KASCADE-Grande array installed at the Forschungszentrum Karlsruhe, Germany The measured energy deposits of particles in the 37 scintillation detector stations have been used to reconstruct the lateral charged particle distributions that are described by a Linsley parameterization (LDF). Among other features, the S(500) dependence from the EAS angle of incidence has been studied.
Short-distance matrix elements for $D$-meson mixing for 2+1 lattice QCD
Chang, Chia Cheng
We study the short-distance hadronic matrix elements for D-meson mixing with partially quenched Nf = 2+1 lattice QCD. We use a large set of the MIMD Lattice Computation Collaboration's gauge configurations with a2 tadpole-improved staggered sea quarks and tadpole-improved Lüscher-Weisz gluons. We use the a2 tadpole-improved action for valence light quarks and the Sheikoleslami-Wohlert action with the Fermilab interpretation for the valence charm quark. Our calculation covers the complete set of five operators needed to constrain new physics models for D-meson mixing. We match our matrix elements to the MS-NDR scheme evaluated at 3 GeV. We report values for the Beneke-Buchalla-Greub-Lenz-Nierste choice of evanescent operators.
Detecting Distance between Injected Microspheres and Target Tumor via 3D Reconstruction of Tissue Sections
Carson, James P.; Kuprat, Andrew P.; Colby, Sean M.; Davis, Cassi A.; Basciano, Christopher; Greene, Kevin; Feo, John T.; Kennedy, Andrew
One treatment increasing in use for solid tumors in the liver is radioembolization via the delivery of 90Y microspheres to the vascular bed within or near the location of the tumor. It is desirable as part of the treatment for the microspheres to embed preferentially in or near the tumor. This work details an approach for analyzing the deposition of microspheres with respect to the location of the tumor. The approach used is based upon thin-slice serial sectioning of the tissue sample, followed by high resolution imaging, microsphere detection, and 3-D reconstruction of the tumor surface. Distance from the microspheres to the tumor was calculated using a fast deterministic point inclusion method.
Photospheric magnitude diagrams for type II supernovat: A promising tool to compute distances
Rodríguez, Ósmar; Clocchiatti, Alejandro; Hamuy, Mario
We develop an empirical color-based standardization for Type II supernovae (SNe II), equivalent to the classical surface brightness method given in Wesselink. We calibrate this standardization using SNe II with host galaxy distances measured using Cepheids, and a well-constrained shock breakout epoch and extinction due to the host galaxy. We estimate the reddening with an analysis of the B – V versus V – I color-color curves, similar to that of Natali et al. With four SNe II meeting the above requirements, we build a photospheric magnitude versus color diagram (similar to an H-R diagram) with a dispersion of 0.29 mag. We also show that when using time since shock breakout instead of color as the independent variable, the same standardization gives a dispersion of 0.09 mag. Moreover, we show that the above time-based standardization corresponds to the generalization of the standardized candle method of Hamuy and Pinto for various epochs throughout the photospheric phase. To test the new tool, we construct Hubble diagrams for different subsamples of 50 low-redshift (cz < 10{sup 4} km s{sup –1}) SNe II. For 13 SNe within the Hubble flow (cz {sub CMB} > 3000 km s{sup –1}) and with a well-constrained shock breakout epoch we obtain values of 68-69 km s{sup –1} Mpc{sup –1} for the Hubble constant and a mean intrinsic scatter of 0.12 mag or 6% in relative distances.
Effect Of Platooning on Fuel Consumption of Class 8 Vehicles Over a Range of Speeds, Following Distances, and Mass
Lammert, M. P.; Duran, A.; Diez, J.; Burton, K.; Nicholson, A.
This research project evaluates fuel consumption results of two Class 8 tractor-trailer combinations platooned together compared to their standalone fuel consumption. A series of ten modified SAE Type II J1321 fuel consumption track tests were performed to document fuel consumption of two platooned vehicles and a control vehicle at varying steady-state speeds, following distances, and gross vehicle weights (GVWs). The steady-state speeds ranged from 55 mph to 70 mph, the following distances ranged from a 20-ft following distance to a 75-ft following distance, and the GVWs were 65K lbs and 80K lbs. All tractors involved had U.S. Environmental Protection Agency (EPA) SmartWay-compliant aerodynamics packages installed, and the trailers were equipped with side skirts. Effects of vehicle speed, following distance, and GVW on fuel consumption were observed and analyzed. The platooning demonstration system used in this study consisted of radar systems, Dedicated Short-Range Communication (DSRC) vehicle-to-vehicle (V2V) communications, vehicle braking and torque control interface, cameras and driver displays. The lead tractor consistently demonstrated an improvement in average fuel consumption reduction as following distance decreased, with results showing 2.7% to 5.3% fuel savings at a GVW of 65k. The trailing vehicle achieved fuel consumption savings ranging from 2.8% to 9.7%; tests during which the engine cooling fan did not operate achieved savings of 8.4% to 9.7%. 'Team' fuel savings, considering the platooned vehicles as one, ranged from 3.7% to 6.4%, with the best combined result being for 55 mph, 30-ft following distance, and 65k GVW.
Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells
Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan
Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: � Arsenite evokes IL-6 secretion. � IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. � Inflammation is involved in arsenite-induced EMT.
Conn, A. R.; Parker, Q. A.; Zucker, D. B.; Ibata, R. A.; Martin, N. F.; Lewis, G. F.; McConnachie, A. W.; Irwin, M. J.; Chapman, S. C.; Tanvir, N.; Fardal, M. A.; Ferguson, A. M. N.; Valls-Gabaud, D.
In 'A Bayesian Approach to Locating the Red Giant Branch Tip Magnitude (Part I)', a new technique was introduced for obtaining distances using the tip of the red giant branch (TRGB) standard candle. Here we describe a useful complement to the technique with the potential to further reduce the uncertainty in our distance measurements by incorporating a matched-filter weighting scheme into the model likelihood calculations. In this scheme, stars are weighted according to their probability of being true object members. We then re-test our modified algorithm using random-realization artificial data to verify the validity of the generated posterior probability distributions (PPDs) and proceed to apply the algorithm to the satellite system of M31, culminating in a three-dimensional view of the system. Further to the distributions thus obtained, we apply a satellite-specific prior on the satellite distances to weight the resulting distance posterior distributions, based on the halo density profile. Thus in a single publication, using a single method, a comprehensive coverage of the distances to the companion galaxies of M31 is presented, encompassing the dwarf spheroidals Andromedas I-III, V, IX-XXVII, and XXX along with NGC 147, NGC 185, M33, and M31 itself. Of these, the distances to Andromedas XXIV-XXVII and Andromeda XXX have never before been derived using the TRGB. Object distances are determined from high-resolution tip magnitude posterior distributions generated using the Markov Chain Monte Carlo technique and associated sampling of these distributions to take into account uncertainties in foreground extinction and the absolute magnitude of the TRGB as well as photometric errors. The distance PPDs obtained for each object both with and without the aforementioned prior are made available to the reader in tabular form. The large object coverage takes advantage of the unprecedented size and photometric depth of the Pan-Andromeda Archaeological Survey. Finally, a
Differential cross sections for the reactions and
Williams, M.; Krahn, Z.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Bookwalter, C.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D'Angelo, A.; Daniel, A.; Vita, R. De; Sanctis, E. De; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mikhailov, K.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pieschacon, D.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.
In high-statistics differential cross sections for the reactions γ p -> p η and γ p -> p η' the CLAS at Jefferson Lab was used to measure the center-of-mass energies from near threshold up to 2.84 GeV. The eta-prime results are the most precise to date and provide the largest energy and angular coverage. The eta measurements extend the energy range of the world's large-angle results by approximately 300 MeV. These new data, in particular the η' measurements, are likely to help constrain the analyses being performed to search for new baryon resonance states.
Self-selection contributes significantly to the lower adiposity offaster, longer-distanced, male and female walkers
Williams, Paul T.
Although cross-sectional studies show active individuals areleaner than their sedentary counterparts, it remains to be determined towhat extent this is due to initially leaner men and women choosing toexercise longer and more intensely (self-selection bias). In this reportwalking volume (weekly distance) and intensity (speed) were compared tocurrent BMI (BMIcurrent) and BMI at the start of walking (BMIstarting) in20,353 women and 5,174 men who had walked regularly for exercise for 7.2and 10.6 years,respectively. The relationships of BMIcurrent andBMIstarting with distance and intensity were nonlinear (convex). Onaverage, BMIstarting explained>70 percent of the association betweenBMIcurrent and intensity, and 40 percent and 17 percent of theassociation between BMIcurrent and distance in women and men,respectively. Although the declines in BMIcurrent with distance andintensity were greater among fatter than leaner individuals, the portionsattributable to BMIstarting remained relatively constant regardless offatness. Thus self-selection bias accounts for most of the decline in BMIwith walking intensity and smaller albeit significant proportions of thedecline with distance. This demonstration of self-selection is germane toother cross-sectional comparisons in epidemiological research, givenself-selection is unlikely to be limited to weight or peculiar tophysical activity.
Gain analysis of higher-order-mode amplification in a dielectric-implanted multi-beam traveling wave structure
Gee, Anthony; Shin, Young-Min
A multi-beam traveling wave amplifier designed with an overmoded staggered double grating array was examined by small signal analysis combined with simulation. Eigenmode and S-parameter analyses show that the 2cm long slow wave structure (SWS) has 1-5dB insertion loss over the passband (TM31 mode) with ~28% cold bandwidth. Analytic gain calculation indicates that in the SWS, TM31-mode is amplified with 15–20 dB/beam at 64–84GHz with three elliptical beams of 10kV and 150mA/beam, which was compared with particle-in-cell (PIC) simulations. PIC analysis on the analysis of instability with zero-input driving excitations demonstrated that background noises and non-operating lower order modes are noticeably suppressed by implanting equidistant dielectric absorbers; the overmoded structure only allowed the desired 3rd order mode to propagate in the structure. The designed circuit structure can be widely applied to multi-beam devices for high power RF generation.
A traveling-wave forward coupler design for a new accelerating mode in a silicon woodpile accelerator
Wu, Ziran; Lee, Chunghun H.; Wootton, Kent P.; Ng, Cho -Kuen; Qi, Minghao H.; England, Robert J.
Silicon woodpile photonic crystals provide a base structure that can be used to build a three-dimensional dielectric waveguide system for high-gradient laser driven acceleration. A new woodpile waveguide design that hosts a phase synchronous, centrally confined accelerating mode is proposed. Comparing with previously discovered silicon woodpile accelerating modes, this mode shows advantages in terms of better electron beam loading and higher achievable acceleration gradient. Several traveling-wave coupler design schemes developed for multi-cell RF cavity accelerators are adapted to the woodpile power coupler design for this new accelerating mode. Design of a forward coupled, highly efficient silicon woodpile accelerator is achieved.more » Simulation shows high efficiency of over 75% of the drive laser power coupled to this fundamental accelerating mode, with less than 15% backward wave scattering. The estimated acceleration gradient, when the coupler structure is driven at the damage threshold fluence of silicon at its operating 1.506 μm wavelength, can reach 185 MV/m. Lastly, a 17-layer woodpile waveguide structure was successfully fabricated, and the measured bandgap is in excellent agreement with simulation.« less
Superluminous supernovae as standardizable candles and high-redshift distance probes
Inserra, C.; Smartt, S. J.
We investigate the use of type Ic superluminous supernovae (SLSN Ic) as standardizable candles and distance indicators. Their appeal as cosmological probes stems from their remarkable peak luminosities, hot blackbody temperatures, and bright rest-frame ultraviolet emission. We present a sample of 16 published SLSN, from redshifts 0.1 to 1.2, and calculate accurate K corrections to determine uniform magnitudes in 2 synthetic rest-frame filter bandpasses with central wavelengths at 400 nm and 520 nm. At 400 nm, we find an encouragingly low scatter in their uncorrected, raw mean magnitudes with M(400) = –21.86 ± 0.35 mag for the full sample of 16 objects. We investigate the correlation between their decline rates and peak magnitude and find that the brighter events appear to decline more slowly. In a manner similar to the Phillips relation for type Ia SNe (SNe Ia), we define a ΔM {sub 20} decline relation. This correlates peak magnitude and decline over 20 days and can reduce the scatter in standardized peak magnitudes to ±0.22 mag. We further show that M(400) appears to have a strong color dependence. Redder objects are fainter and also become redder faster. Using this peak magnitudecolor evolution relation, a surprisingly low scatter of between ±0.08 mag and ±0.13 mag can be found in peak magnitudes, depending on sample selection. However, we caution that only 8 to 10 objects currently have enough data to test this peak magnitudecolor evolution relation. We conclude that SLSN Ic are promising distance indicators in the high-redshift universe in regimes beyond those possible with SNe Ia. Although the empirical relationships are encouraging, the unknown progenitor systems, how they may evolve with redshift, and the uncertain explosion physics are of some concern. The two major measurement uncertainties are the limited numbers of low-redshift, well-studied objects available to test these relationships and internal dust extinction in the host galaxies.
Determination of lung segments in computed tomography images using the Euclidean distance to the pulmonary artery
Stoecker, Christina; Moltz, Jan H.; Lassen, Bianca; Kuhnigk, Jan-Martin; Krass, Stefan; Welter, Stefan; Peitgen, Heinz-Otto
Purpose: Computed tomography (CT) imaging is the modality of choice for lung cancer diagnostics. With the increasing number of lung interventions on sublobar level in recent years, determining and visualizing pulmonary segments in CT images and, in oncological cases, reliable segment-related information about the location of tumors has become increasingly desirable. Computer-assisted identification of lung segments in CT images is subject of this work.Methods: The authors present a new interactive approach for the segmentation of lung segments that uses the Euclidean distance of each point in the lung to the segmental branches of the pulmonary artery. The aim is to analyze the potential of the method. Detailed manual pulmonary artery segmentations are used to achieve the best possible segment approximation results. A detailed description of the method and its evaluation on 11 CT scans from clinical routine are given.Results: An accuracy of 2–3 mm is measured for the segment boundaries computed by the pulmonary artery-based method. On average, maximum deviations of 8 mm are observed. 135 intersegmental pulmonary veins detected in the 11 test CT scans serve as reference data. Furthermore, a comparison of the presented pulmonary artery-based approach to a similar approach that uses the Euclidean distance to the segmental branches of the bronchial tree is presented. It shows a significantly higher accuracy for the pulmonary artery-based approach in lung regions at least 30 mm distal to the lung hilum.Conclusions: A pulmonary artery-based determination of lung segments in CT images is promising. In the tests, the pulmonary artery-based determination has been shown to be superior to the bronchial tree-based determination. The suitability of the segment approximation method for application in the planning of segment resections in clinical practice has already been verified in experimental cases. However, automation of the method accompanied by an evaluation on a larger
Humphreys, E. M. L.; Reid, M. J.; Moran, J. M.; Greenhill, L. J.; Argon, A. L.
We report a new geometric maser distance estimate to the active galaxy NGC 4258. The data for the new model are maser line-of-sight (LOS) velocities and sky positions from 18 epochs of very long baseline interferometry observations, and LOS accelerations measured from a 10 yr monitoring program of the 22 GHz maser emission of NGC 4258. The new model includes both disk warping and confocal elliptical maser orbits with differential precession. The distance to NGC 4258 is 7.60 {+-} 0.17 {+-} 0.15 Mpc, a 3% uncertainty including formal fitting and systematic terms. The resulting Hubble constant, based on the use of the Cepheid variables in NGC 4258 to recalibrate the Cepheid distance scale, is H{sub 0} = 72.0 {+-} 3.0 km s{sup -1} Mpc{sup -1}.
Svanda, Michal; Roudier, Thierry; Rieutord, Michel; Burston, Raymond; Gizon, Laurent
We compare measurements of horizontal flows on the surface of the Sun using helioseismic time-distance inversions and coherent structure tracking of solar granules. Tracking provides two-dimensional horizontal flows on the solar surface, whereas the time-distance inversions estimate the full three-dimensional velocity flows in the shallow near-surface layers. Both techniques use Helioseismic and Magnetic Imager observations as input. We find good correlations between the various measurements resulting from the two techniques. Further, we find a good agreement between these measurements and the time-averaged Doppler line-of-sight velocity, and also perform sanity checks on the vertical flow that resulted from the three-dimensional time-distance inversion.
SU-E-T-98: Dependence of Radiotherapy Couch Transmission Factors On Field Size and Couch-Isocenter Distance
Benhabib, S; Duan, J; Wu, X; Cardan, R; Shen, S; Huang, M; Popple, R; Brezovich, I
Purpose: The dosimetric effect of the treatment couch is non-negligible in today's radiotherapy treatment. To accurately include couch in dose calculation, we investigated the dependence of couch transmission factors on field size and couch-isocenter distance. Methods: Couch transmission factors for Varian Exact Couch were determined by taking the ratios of ionization of a posterior-anterior beam with and without the couch in the beam path. Measurements were performed at the isocenter using a PTW cylindrical ionization chamber (Model 31030) with an Aluminum buildup cap of 1.1 cm thick for the 6 MV photon beam. Ionization readings for beam sizes ranging from 2 � 2 cm2 to 40 � 40 cm2 were taken. Transmission factors for couch-isocenter distances ranging from 3 cm to 20 cm were also investigated. Results: The couch transmission factors increased with the field size approximately in an exponential manner. For the field sizes that we tested, the transmission factor ranged from 0.976 to 0.992 for couch-isocenter distance of 3 cm. The transmission factor was also monotonically dependent on couch-isocenter separation distance, but in a lighter magnitude. For the tested couch heights, the transmission factor ranged from 0.974 � 0.972 for 2 � 2 cm2 field size and 0.992 � 0.986 for 40 � 40 cm2 field size. The dependence on couch-isocenter distance is stronger for larger field size. Conclusions: The transmission factor of a radiotherapy treatment couch increases with field size of the radiation beam and its distance from the isocenter. Such characterization of the couch transmission factor helps improve the accuracy of couch modeling for radiotherapy treatment planning.
Inno, L.; Bono, G.; Buonanno, R.; Genovali, K.; Matsunaga, N.; Caputo, F.; Laney, C. D.; Marconi, M.; Piersimoni, A. M.; Primas, F.; Romaniello, M.
We present the largest near-infrared (NIR) data sets, JHKs, ever collected for classical Cepheids in the Magellanic Clouds (MCs). We selected fundamental (FU) and first overtone (FO) pulsators, and found 4150 (2571 FU, 1579 FO) Cepheids for Small Magellanic Cloud (SMC) and 3042 (1840 FU, 1202 FO) for Large Magellanic Cloud (LMC). Current sample is 2-3 times larger than any sample used in previous investigations with NIR photometry. We also discuss optical VI photometry from OGLE-III. NIR and optical-NIR Period-Wesenheit (PW) relations are linear over the entire period range (0.0 < log P {sub FU} {<=} 1.65) and their slopes are, within the intrinsic dispersions, common between the MCs. These are consistent with recent results from pulsation models and observations suggesting that the PW relations are minimally affected by the metal content. The new FU and FO PW relations were calibrated using a sample of Galactic Cepheids with distances based on trigonometric parallaxes and Cepheid pulsation models. By using FU Cepheids we found a true distance moduli of 18.45 {+-} 0.02(random) {+-} 0.10(systematic) mag (LMC) and 18.93 {+-} 0.02(random) {+-} 0.10(systematic) mag (SMC). These estimates are the weighted mean over 10 PW relations and the systematic errors account for uncertainties in the zero point and in the reddening law. We found similar distances using FO Cepheids (18.60 {+-} 0.03(random) {+-} 0.10(systematic) mag (LMC) and 19.12 {+-} 0.03(random) {+-} 0.10(systematic) mag (SMC)). These new MC distances lead to the relative distance, {Delta}{mu} = 0.48 {+-} 0.03 mag (FU, log P = 1) and {Delta}{mu} = 0.52 {+-} 0.03 mag (FO, log P = 0.5), which agrees quite well with previous estimates based on robust distance indicators.
Ecloud Build-Up Simulations for the FNAL MI for a Mixed Fill Pattern: Dependence on Peak SEY and Pulse Intensity During the Ramp
Furman, M. A.
We present simulation results of the build-up of the electron-cloud density n{sub e} in three regions of the FNAL Main Injector (MI) for a beam fill pattern made up of 5 double booster batches followed by a 6th single batch. We vary the pulse intensity in the range N{sub t} = (2-5) x 10{sup 13}, and the beam kinetic energy in the range E{sub k} = 8-120 GeV. We assume a secondary electron emission model qualitatively corresponding to TiN, except that we let the peak value of the secondary electron yield (SEY) {delta}{sub max} vary as a free parameter in a fairly broad range. Our main conclusions are: (1) At fixed N{sub t} there is a clear threshold behavior of n{sub e} as a function of {delta}{sub max} in the range {approx} 1.1-1.3. (2) At fixed {delta}{sub max}, there is a threshold behavior of n{sub e} as a function of N{sub t} provided {delta}{sub max} is sufficiently high; the threshold value of N{sub t} is a function of the characteristics of the region being simulated. (3) The dependence on E{sub k} is weak except possibly at transition energy. Most of these results were informally presented to the relevant MI personnel in April 2010.
Simulated Fuel Economy and Performance of Advanced Hybrid Electric and Plug-in Hybrid Electric Vehicles Using In-Use Travel Profiles
Earleywine, M.; Gonder, J.; Markel, T.; Thornton, M.
As vehicle powertrain efficiency increases through electrification, consumer travel and driving behavior have significantly more influence on the potential fuel consumption of these vehicles. Therefore, it is critical to have a good understanding of in-use or 'real world' driving behavior if accurate fuel consumption estimates of electric drive vehicles are to be achieved. Regional travel surveys using Global Positioning System (GPS) equipment have been found to provide an excellent source of in-use driving profiles. In this study, a variety of vehicle powertrain options were developed and their performance was simulated over GPS-derived driving profiles for 783 vehicles operating in Texas. The results include statistical comparisons of the driving profiles versus national data sets, driving performance characteristics compared with standard drive cycles, and expected petroleum displacement benefits from the electrified vehicles given various vehicle charging scenarios.
Distance dependent quenching and gamma-ray spectroscopy in tin-loaded polystyrene scintillators
Feng, Patrick L; Mengesha, Wondwosen; Anstey, Mitchell R.; Cordaro, Joseph Gabriel
In this study, we report the synthesis and inclusion of rationally designed organotin compounds in polystyrene matrices as a route towards plastic scintillators capable of gamma-ray spectroscopy. Tin loading ratios of up to 15% w/w have been incorporated, resulting in photopeak energy resolution values as low as 10.9% for 662 keV gamma-rays. Scintillator constituents were selected based upon a previously reported distance-dependent quenching mechanism. Data obtained using UV-Vis and photoluminescence measurements are consistent with this phenomenon and are correlated with the steric and electronic properties of the respective organotin complexes. We also report fast scintillation decay behavior that is comparablemore » to the quenched scintillators 0.5% trans-stilbene doped bibenzyl and the commercial plastic scintillator BC-422Q-1%. These observations are discussed in the context of practical considerations such as optical transparency, ease-of-preparation/scale-up, and total scintillator cost.« less
Recoil Distance Method Lifetime Measurements in 107Cd and 103Pd
Andgren, K.; Ashley, S. F.; Regan, P. H.; McCutchan, E. A.; Zamfir, N. V.; Casten, R. F.; Meyer, D. A.; Plettner, C.; Vinson, J.; Werner, V.; Williams, E.; Amon, L.; Cakirli, R. B.; Erduran, M. N.; Clark, R. M.; Guerdal, G.; Keyes, K. L.; Papenberg, A.; Pietralla, N.; Rainovski, G.
Preliminary lifetime values have been measured for a number of near-yrast states in the odd-A transitional nuclei 107Cd and 103Pd. The reaction used to populate the nuclei of interest was 98Mo(12C,3nx{alpha})107Cd, 103Pd, with the beam delivered by the tandem accelerator of the Wright Nuclear Structure Laboratory at an incident beam energy of 60 MeV. Our experiment was aimed at the investigation of collective excitations built on the unnatural parity, {nu} h11/2 orbital, specifically by measuring the B(E2) values of decays from the excited levels built on this intrinsic structure, using the Doppler Recoil Distance Method. We report lifetimes and associated transition probabilities for decays from the 15/2- and the 19/2- states in 107Cd and the first measurement of the 15/2- state in 103Pd. These results suggest that neither a simple rotational or vibrational interpretation is sufficient to explain the observed structures.
Luminosity distance in 'Swiss cheese' cosmology with randomized voids. I. Single void size
Vanderveld, R. Ali; Flanagan, Eanna E.; Wasserman, Ira
Recently, there have been suggestions that the Type Ia supernova data can be explained using only general relativity and cold dark matter with no dark energy. In 'Swiss cheese' models of the Universe, the standard Friedmann-Robertson-Walker picture is modified by the introduction of mass-compensating spherical inhomogeneities, typically described by the Lemaitre-Tolman-Bondi metric. If these inhomogeneities correspond to underdense cores surrounded by mass-compensating overdense shells, then they can modify the luminosity distance-redshift relation in a way that can mimic accelerated expansion. It has been argued that this effect could be large enough to explain the supernova data without introducing dark energy or modified gravity. We show that the large apparent acceleration seen in some models can be explained in terms of standard weak field gravitational lensing together with insufficient randomization of void locations. The underdense regions focus the light less than the homogeneous background, thus dimming supernovae in a way that can mimic the effects of acceleration. With insufficient randomization of the spatial location of the voids and of the lines of sight, coherent defocusing can lead to anomalously large demagnification effects. We show that a proper randomization of the voids and lines of sight reduces the effect to the point that it can no longer explain the supernova data.
Laser-ablation sampling for inductively coupled plasma distance-of-flight mass spectrometry
Gundlach-Graham, Alexander W.; Dennis, Elise; Ray, Steven J.; Enke, Christie G.; Barinaga, Charles J.; Koppenaal, David W.; Hieftje, Gary M.
An inductively coupled plasma distance-of-flight mass spectrometer (ICP-DOFMS) has been coupled with laser-ablation (LA) sample introduction for the elemental analysis of solids. ICP-DOFMS is well suited for the analysis of laser-generated aerosols because it offers both high-speed mass analysis and simultaneous multi-elemental detection. Here, we evaluate the analytical performance of the LA-ICP-DOFMS instrument, equipped with a microchannel plate-based imaging detector, for the measurement of steady-state LA signals, as well as transient signals produced from single LA events. Steady-state detection limits are 1 mg g1, and absolute single-pulse LA detection limits are 200 fg for uranium; the system is shown capable of performing time-resolved single-pulse LA analysis. By leveraging the benefits of simultaneous multi-elemental detection, we also attain a good shot-to-shot reproducibility of 6% relative standard deviation (RSD) and isotope-ratio precision of 0.3% RSD with a 10 s integration time.
Effects of inter-nanocrystal distance on luminescence quantum yield in ensembles of Si nanocrystals
Valenta, J. Greben, M.; Gutsch, S.; Hiller, D.; Zacharias, M.
The absolute photoluminescence (PL) quantum yield (QY) of multilayers of Silicon nanocrystals (SiNCs) separated by SiO{sub 2} barriers were thoroughly studied as function of the barrier thickness, excitation wavelength, and temperature. By mastering the plasma-enhanced chemical vapor deposition growth, we produce a series of samples with the same size-distribution of SiNCs but variable interlayer barrier distance. These samples enable us to clearly demonstrate that the increase of barrier thickness from ∼1 to larger than 2 nm induces doubling of the PL QY value, which corresponds to the change of number of close neighbors in the hcp structure. The temperature dependence of PL QY suggests that the PL QY changes are due to a thermally activated transport of excitation into non-radiative centers in dark NCs or in the matrix. We estimate that dark NCs represent about 68% of the ensemble of NCs. The PL QY excitation spectra show no significant changes upon changing the barrier thickness and no clear carrier multiplication effects. The dominant effect is the gradual decrease of the PL QY with increasing excitation photon energy.
Atmospheric plume progression as a function of time and distance from the release point for radioactive isotopes
Eslinger, Paul W.; Bowyer, Ted W.; Cameron, Ian M.; Hayes, James C.; Miley, Harry S.
The International Monitoring System contains up to 80 stations around the world that have aerosol and xenon monitoring systems designed to detect releases of radioactive materials to the atmosphere from nuclear tests. A rule of thumb description of plume concentration and duration versus time and distance from the release point is useful when designing and deploying new sample collection systems. This paper uses plume development from atmospheric transport modeling to provide a power-law rule describing atmospheric dilution factors as a function of distance from the release point.
The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978
Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)
Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof
Dependance of TWRS FSAR X/Qs on distance and example doses at Highway 240 with stationary and moving receptors
Himes, D.A.
A discussion of the reasons for the dependance of X/Q on receptor distance and compass sector is presented. In addition, X/Qs are calculated for three receptor scenarios on Highway 240 including a moving receptor. Example radiological doses and toxicological exposures at Highway 240 are calculated for two accidents already analyzed in the TWRS FSAR.
Going the Distance? NRC's Response to the National Academy of Science's Transportation Study
Easton, E.P.; Bajwa, C.S.
In February 2006, the National Academy of Sciences (NAS) published the results of a 3 1/2-year study, titled Going the Distance, that examined the safety of transporting spent nuclear fuel (SNF) and high level waste (HLW) in the United States. NAS initiated this study to address what it perceived to be a national need for an independent, objective, and authoritative analysis of SNF and HLW transport in the United States. The study was co-sponsored by the U.S. Nuclear Regulatory Commission (NRC), the U.S. Department of Energy (DOE), the U.S. Department of Transportation (DOT), the Electric Power Research Institute and the National Cooperative Highway Research Program. This paper addresses some of the recommendations made in the NAS study related to the performance of SNF transportation casks in long duration fires, the use of full-scale package testing, and the need for an independent review of transportation security prior to the commencement of large scale shipping campaigns to an interim storage site or geologic repository. In conclusion: The NRC believes that the current regulations in 10 CFR Part 71 for the design of SNF and HLW transportation packages provide a very high level of protection to the public for very severe accidents and credible threat scenarios. As recommended by the NAS study, additional studies of accidents involving severe fires have been completed. These studies have confirmed that spent fuel casks would be expected to withstand very severe fires without the release of any fission products from the spent fuel. Additionally, changes in rail operating procedures such as the use of dedicated trains and prohibition on the co-location of SNF and flammable liquids in rail tunnels can further reduce the already low probability of severe rail accident fires involving SNF and HLW. (authors)
Post, R.F.
The invention relates to a pyrotron, i.e., magnetic mirror device, designed for continuous operation in producing a high-temperature fusion reaction plasma and for directly converting the plasma energy into electrical power. The device utilizes a system in which an axially symmetric magnetic field is produced and transports plasma through a first zone of progressively rising field intensity, a second reaction zone of slowly increasing intensity, and thenceforth through a third zone of progressively decreasing intensity wherein the plasma expands against the magnetic field thereby producing electrical current in magnetic field generating solenoids associated with said third zone. (AEC)
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A parallax distance to the microquasar GRS 1915+105 and a revised estimate of its black hole mass
Reid, M. J.; McClintock, J. E.; Steiner, J. F.; Narayan, R.; Steeghs, D.; Remillard, R. A.; Dhawan, V.
Using the Very Long Baseline Array, we have measured a trigonometric parallax for the microquasar GRS 1915+105, which contains a black hole and a K-giant companion. This yields a direct distance estimate of 8.6{sub ?1.6}{sup +2.0} kpc and a revised estimate for the mass of the black hole of 12.4{sub ?1.8}{sup +2.0} M {sub ?}. GRS 1915+105 is at about the same distance as some H II regions and water masers associated with high-mass star formation in the Sagittarius spiral arm of the Galaxy. The absolute proper motion of GRS 1915+105 is �3.19 � 0.03 mas yr{sup �1} and �6.24 � 0.05 mas yr{sup �1} toward the east and north, respectively, which corresponds to a modest peculiar speed of 22 � 24 km s{sup �1} at the parallax distance, suggesting that the binary did not receive a large velocity kick when the black hole formed. On one observational epoch, GRS 1915+105 displayed superluminal motion along the direction of its approaching jet. Considering previous observations of jet motions, the jet in GRS 1915+105 can be modeled with a jet inclination to the line of sight of 60� � 5� and a variable flow speed between 0.65c and 0.81c, which possibly indicates deceleration of the jet at distances from the black hole ? 2000 AU. Finally, using our measurements of distance and estimates of black hole mass and inclination, we provisionally confirm our earlier result that the black hole is spinning very rapidly.
Trigonometric distance and proper motion of IRAS 20056+3350: a massive star-forming region on the solar circle
Burns, Ross A.; Handa, Toshihiro; Omodaka, Toshihiro; Nakagawa, Akiharu; Nakanishi, Hiroyuki [Graduate School of Science and Engineering, Kagoshima University, 1-21-35 K�rimoto, Kagoshima, Kagoshima 890-0065 (Japan); Nagayama, Takumi [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Hayashi, Masahiko [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Shizugami, Makoto, E-mail: email@example.com [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-12 Hoshi-ga-oka, Mizusawa-ku, Oshu, Iwate 023-0861 (Japan)
We report our measurement of the trigonometric distance and proper motion of IRAS 20056+3350, obtained from the annual parallax of H{sub 2}O masers. Our distance of D=4.69{sub ?0.51}{sup +0.65} kpc, which is 2.8 times larger than the near kinematic distance adopted in the literature, places IRAS 20056+3350 at the leading tip of the Local arm and proximal to the solar circle. Using our distance, we reevaluate past observations to reveal IRAS 20056+3350 as a site of massive star formation at a young stage of evolution. This result is consistent with the spectral energy distribution of the source evaluated with published photometric data from UKIDSS, WISE, AKARI, IRAS, and the submillimeter continuum. Both analytical approaches reveal the luminosity of the region to be 2.4 � 10{sup 4} L {sub ?}, and suggest that IRAS 20056+3350 is forming an embedded star of ?16 M {sub ?}. We estimated the proper motion of IRAS 20056+3350 to be (?{sub ?}cos ?, ?{sub ?}) = (�2.62 � 0.33, �5.65 � 0.52) mas yr{sup �1} from the group motion of H{sub 2}O masers, and use our results to estimate the angular velocity of Galactic rotation at the Galactocentric distance of the Sun, ?{sub 0} = 29.75 � 2.29 km s{sup �1} kpc{sup �1}, which is consistent with the values obtained for other tangent point and solar circle objects.
Reactive transport of uranium in fractured crystalline rock: Upscaling in time and distance
Dittrich, Timothy M.; Reimus, Paul W.
In this study, batch adsorption and breakthrough column experiments were conducted to evaluate uranium transport through altered material that fills fractures in a granite rock system at the Grimsel Test Site in Switzerland at pH 6.9 and 7.9. The role of adsorption and desorption kinetics was evaluated with reactive transport modeling by comparing one-, two-, and three-site models. Emphasis was placed on describing long desorption tails that are important for upscaling in time and distance. The effect of increasing pH in injection solutions was also evaluated. For pH 6.9, a three-site model with forward rate constants between 0.07 and 0.8 ml g–1 h–1, reverse rate constants between 0.001 and 0.06 h–1, and site densities of 1.3, 0.104, and 0.026 μmol g–1 for 'weak/fast', 'strong/slow', and 'very strong/very slow' sites provided the best fits. For pH 7.9, a three-site model with forward rate constants between 0.05 and 0.8 mL g–1 h–1, reverse rate constants between 0.001 and 0.6 h–1, and site densities of 1.3, 0.039, and 0.013 μmol g–1 for a 'weak/fast', 'strong/slow', and 'very strong/very slow' sites provided the best fits. Column retardation coefficients (Rd) were 80 for pH 6.9 and 10.3 for pH 7.9. Model parameters determined from the batch and column experiments were used in 50 year large-scale simulations for continuous and pulse injections and indicated that a three-site model is necessary at pH 6.9, although a Kd-type equilibrium partition model with one-site was adequate for large scale predictions at pH 7.9. Batch experiments were useful for predicting early breakthrough times in the columns while column experiments helped differentiate the relative importance of sorption sites and desorption rate constants on transport.
Reactive transport of uranium in fractured crystalline rock: Upscaling in time and distance
Dittrich, Timothy M.; Reimus, Paul W.
In this study, batch adsorption and breakthrough column experiments were conducted to evaluate uranium transport through altered material that fills fractures in a granite rock system at the Grimsel Test Site in Switzerland at pH 6.9 and 7.9. The role of adsorption and desorption kinetics was evaluated with reactive transport modeling by comparing one-, two-, and three-site models. Emphasis was placed on describing long desorption tails that are important for upscaling in time and distance. The effect of increasing pH in injection solutions was also evaluated. For pH 6.9, a three-site model with forward rate constants between 0.07 and 0.8more » ml g–1 h–1, reverse rate constants between 0.001 and 0.06 h–1, and site densities of 1.3, 0.104, and 0.026 μmol g–1 for 'weak/fast', 'strong/slow', and 'very strong/very slow' sites provided the best fits. For pH 7.9, a three-site model with forward rate constants between 0.05 and 0.8 mL g–1 h–1, reverse rate constants between 0.001 and 0.6 h–1, and site densities of 1.3, 0.039, and 0.013 μmol g–1 for a 'weak/fast', 'strong/slow', and 'very strong/very slow' sites provided the best fits. Column retardation coefficients (Rd) were 80 for pH 6.9 and 10.3 for pH 7.9. Model parameters determined from the batch and column experiments were used in 50 year large-scale simulations for continuous and pulse injections and indicated that a three-site model is necessary at pH 6.9, although a Kd-type equilibrium partition model with one-site was adequate for large scale predictions at pH 7.9. Batch experiments were useful for predicting early breakthrough times in the columns while column experiments helped differentiate the relative importance of sorption sites and desorption rate constants on transport.« less
Measuring distances and reddenings for a billion stars: Toward a 3D dust map from Pan-STARRS 1
Green, Gregory Maurice; Finkbeiner, Douglas P.; Schlafly, Edward F.; Rix, Hans-Walter; Juri?, Mario; Burgett, Will; Chambers, Kenneth C.; Flewelling, Heather; Kudritzki, Rolf Peter; Magnier, Eugene; Tonry, John; Wainscoat, Richard; Waters, Christopher; Draper, Peter W.; Metcalfe, Nigel; Martin, Nicolas
We present a method to infer reddenings and distances to stars based only on their broad-band photometry, and show how this method can be used to produce a three-dimensional (3D) dust map of the Galaxy. Our method samples from the full probability density function of distance, reddening, and stellar type for individual stars, as well as the full uncertainty in reddening as a function of distance in the 3D dust map. We incorporate prior knowledge of the distribution of stars in the Galaxy and the detection limits of the survey. For stars in the Pan-STARRS 1 (PS1) 3? survey, we demonstrate that our reddening estimates are unbiased and accurate to ?0.13 mag in E(B � V) for the typical star. Based on comparisons with mock catalogs, we expect distances for main-sequence stars to be constrained to within ?20%-60%, although this range can vary, depending on the reddening of the star, the precise stellar type, and its position on the sky. A later paper will present a 3D map of dust over the three quarters of the sky surveyed by PS1. Both the individual stellar inferences and the 3D dust map will enable a wealth of Galactic science in the plane. The method we present is not limited to the passbands of the PS1 survey but may be extended to incorporate photometry from other surveys, such as the Two Micron All Sky Survey, the Sloan Digital Sky Survey (where available), and in the future, LSST and Gaia.
Multi-dimensional modelling of electrostatic force distance curve over dielectric surface: Influence of tip geometry and correlation with experiment
Boularas, A. Baudoin, F.; Villeneuve-Faure, C.; Clain, S.; Teyssedre, G.
Electric Force-Distance Curves (EFDC) is one of the ways whereby electrical charges trapped at the surface of dielectric materials can be probed. To reach a quantitative analysis of stored charge quantities, measurements using an Atomic Force Microscope (AFM) must go with an appropriate simulation of electrostatic forces at play in the method. This is the objective of this work, where simulation results for the electrostatic force between an AFM sensor and the dielectric surface are presented for different bias voltages on the tip. The aim is to analyse force-distance curves modification induced by electrostatic charges. The sensor is composed by a cantilever supporting a pyramidal tip terminated by a spherical apex. The contribution to force from cantilever is neglected here. A model of force curve has been developed using the Finite Volume Method. The scheme is based on the Polynomial Reconstruction Operator�PRO-scheme. First results of the computation of electrostatic force for different tip�sample distances (from 0 to 600?nm) and for different DC voltages applied to the tip (6 to 20?V) are shown and compared with experimental data in order to validate our approach.
Long-Working-Distance Kirkpatrick-Baez Mirrors for Hard X-ray Beamlines at SPring-8
Yumoto, H.; Koyama, T.
We designed and installed two types of long-working-distance Kirkpatrick-Baez (KB) mirrors and mirror manipulators, which were customized into each experiment for hard x-ray undulator beamlines at SPring-8. For the BL32XU RIKEN Targeted Proteins beamline, 400-mm-long KB focusing mirrors for a beam size of 1 {mu}m with a 730-mm-long working distance were designed for carrying out the structural analysis of protein microcrystals. We realized a focusing beam size of 0.9x0.9 {mu}m{sup 2}(FWHM) and a focusing intensity of 6x10{sup 10} (photons/s) at an x-ray energy of 12.4 keV. For the BL19LXU RIKEN SR Physics beamline, we developed KB mirrors for 100-nm focusing with a 100-mm-working distance for the purpose of nano-focus x-ray diffraction. A focusing beam size of 100x100 nm{sup 2}(FWHM) and a high focusing intensity of 3.7x10{sup 10} (photons/s) at an x-ray energy of 12.4 keV were realized.
0.22 THz wideband sheet electron beam traveling wave tube amplifier: Cold test measurements and beam wave interaction analysis
Baig, Anisullah; Gamzina, Diana; Barchfeld, Robert; Domier, Calvin; Barnett, Larry R.; Luhmann, Neville C. Jr.
In this paper, we describe micro-fabrication, RF measurements, and particle-in-cell (PIC) simulation modeling analysis of the 0.22 THz double-vane half period staggered traveling wave tube amplifier (TWTA) circuit. The TWTA slow wave structure comprised of two sections separated by two sever ports loaded by loss material, with integrated broadband input/output couplers. The micro-metallic structures were fabricated using nano-CNC milling and diffusion bonded in a three layer process. The 3D optical microscopy and SEM analysis showed that the fabrication error was within 2-3 {mu}m and surface roughness was measured within 30-50 nm. The RF measurements were conducted with an Agilent PNA-X network analyzer employing WR5.1 T/R modules with a frequency range of 178-228 GHz. The in-band insertion loss (S{sub 21}) for both the short section and long section (separated by a sever) was measured as {approx}-5 dB while the return loss was generally around {approx}-15 dB or better. The measurements matched well with the S-matrix simulation analysis that predicted a 3 dB bandwidth of {approx}45 GHz with an operating frequency at 220 GHz. However, the measured S{sub 21} was {approx}3 dB less than the design values, and is attributed to surface roughness and alignment issues. The confirmation measurements were conducted over the full frequency band up to 270 GHz employing a backward wave oscillator (BWO) scalar network analyzer setup employing a BWO in the frequency range 190 GHz-270 GHz. PIC simulations were conducted for the realistic TWT output power performance analysis with incorporation of corner radius of 127 {mu}m, which is inevitably induced by nano-machining. Furthermore, the S{sub 21} value in both sections of the TWT structure was reduced to correspond to the measurements by using a degraded conductivity of 10% International Annealed Copper Standard. At 220 GHz, for an elliptic sheet electron beam of 20 kV and 0.25 A, the average output power of the tube was predicted