text:
|By Kevin Benedict
Article Rating:
|December 18, 2012 09:00 AM EST
Also read Enterprise Mobility Asia News Weekly
Also read M2M News Weekly
Also read Mobile Commerce News Weekly
Also read Mobile Health News Weekly
Also read Mobility News Weekly
Each of us is impacted by SMAC. We all use mobile devices and social networking solutions like Facebook, Twitter and LinkedIn. We use search engines, maps and weather apps, all of which use analytics and are in the cloud. SMAC is the combination of all of these trends coming together on mobile devices. This convergence is impacting businesses in many different ways. We will do our best to capture these by reporting on the SMAC trends, numbers and forecasts in this weekly newsletter.
Instagram is revising its Privacy Policy and Terms of Service to improve collaboration with Facebook, which acquired Instagram for $715 million earlier this year. The changes, which take effect in January, enable Instagram to share user content and information such as location data, usage data and device identifiers with other Facebook-owned entities. Read Original Content
A survey released earlier this week by IDC in association with EMC revealed the world is now generating data at a rate of 5 exabytes every two days. Gartner has already forecast that in 2013 big data will drive $34 billion worth of IT investment. Read Original Content
Deltek, an enterprise resource planning and IT solutions company that serves government contractors, expects federal spending on Big Data solutions to reach $7.2 billion by 2017 despite some belt-tightening by several government agencies. Read Original Content
While social, mobile, analytics and cloud technologies add a new dimension to your model, to fully maximize their value consider the sum is greater than its parts. The formula for the Future of Work is called SMAC - social, mobile, analytics and cloud on one integrated stack, where each function enables another to maximize their effect. To learn more about SMAC and Cognizant please visit http://www.cognizant.com/futureofwork/smac. This newsletter is sponsored in part by Cognizant.
TechNavio's analysts forecast the Global Big Data-as-a-Service market to grow at an annual rate of 68.93 percent over the period 2012-2016. One of the key factors contributing to this market growth is the demand for cost-effective big data solutions. Read Original Content
For the second time this year, Amazon Simple Storage Service, Google Cloud Storage and Microsoft Windows Azure dropped their cloud storage prices in lock-step over the past few weeks. Read Original Content
Read Original Content
Commonwealth bank has revealed a number of updated and new banking technologies within the mobile and social media space, which it will be launching in 2013.The company will make available a banking service for Facebook. Read Original Content
IBM Corp. will establish an IBM Client Center for Advanced Analytics at its northwest Columbus campus, adding 500 jobs over the next three years. Read Original Content
CIO, CTO & Developer Resources
Recent Articles by Kevin Benedict
Kevin Benedict's What's New in HTML5 - Week of December 9, 2012
Enterprise Mobility, Disinterested Workers and Globalization
Information Operations: The Fifth Dimension of Warfare
The Role Big Data Plays with the Real-Time Enterprise, Mobile Strategies and Field Services
Smart Grids, ERP, Big Data and Mobility
Recorded Webinars of Note
Netcentric Strategies Enterprise Mobility Survey Results
Whitepapers of Note
5 Tips to Minimize the Impact of Rising Fuel Costs in Field Service
On The Road to Agile Mobile Business Applications
Service in 2012 The Continued Search for Revenue
Kevin Benedict, Head Analyst for SMAC, CognizantRead The Future of Work
Follow me on Twitter @krbenedict
Join the Linkedin Group Strategic Enterprise Mobility
Full Disclosure: These are my personal opinions. No company is silly enough to claim them. I am a mobility and SMAC analyst, consultant and writer. I work with and have worked with many of the companies mentioned in my articles.
Read the original blog entry...
@ThingsExpo Stories
SYS-CON Events announced today that Hitachi, the leading provider the Internet of Things and Digital Transformation, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Hitachi Data Systems, a wholly owned subsidiary of Hitachi, Ltd., offers an integrated portfolio of services and solutions that enable digital transformation through enhanced data management, governance, mobility and analytics. We help globa...
Apr. 26, 2017 05:30 AM EDT Reads: 1,035
SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in compute, storage and networking technologies, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/...
Apr. 26, 2017 04:45 AM EDT Reads: 2,115
Amazon has gradually rolled out parts of its IoT offerings in the last year, but these are just the tip of the iceberg. In addition to optimizing their back-end AWS offerings, Amazon is laying the ground work to be a major force in IoT – especially in the connected home and office. Amazon is extending its reach by building on its dominant Cloud IoT platform, its Dash Button strategy, recently announced Replenishment Services, the Echo/Alexa voice recognition control platform, the 6-7 strategic...
Apr. 26, 2017 04:30 AM EDT Reads: 5,270
@GonzalezCarmen has been ranked the Number One Influencer and @ThingsExpo has been named the Number One Brand in the "M2M 2016: Top 100 Influencers and Brands" by Analytic. Onalytica analyzed tweets over the last 6 months mentioning the keywords M2M OR "Machine to Machine." They then identified the top 100 most influential brands and individuals leading the discussion on Twitter.
Apr. 26, 2017 04:15 AM EDT Reads: 1,055
SYS-CON Events announced today that Juniper Networks (NYSE: JNPR), an industry leader in automated, scalable and secure networks, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Juniper Networks challenges the status quo with products, solutions and services that transform the economics of networking. The company co-innovates with customers and partners to deliver automated, scalable and secure network...
Apr. 26, 2017 04:15 AM EDT Reads: 1,214
The age of Digital Disruption is evolving into the next era – Digital Cohesion, an age in which applications securely self-assemble and deliver predictive services that continuously adapt to user behavior. Information from devices, sensors and applications around us will drive services seamlessly across mobile and fixed devices/infrastructure. This evolution is happening now in software defined services and secure networking. Four key drivers – Performance, Economics, Interoperability and Trust ...
Apr. 26, 2017 03:45 AM EDT Reads: 490
Data is an unusual currency; it is not restricted by the same transactional limitations as money or people. In fact, the more that you leverage your data across multiple business use cases, the more valuable it becomes to the organization. And the same can be said about the organization's analytics. In his session at 19th Cloud Expo, Bill Schmarzo, CTO for the Big Data Practice at Dell EMC, introduced a methodology for capturing, enriching and sharing data (and analytics) across the organization...
Apr. 26, 2017 03:15 AM EDT Reads: 6,600
SYS-CON Events announced today that T-Mobile will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. As America's Un-carrier, T-Mobile US, Inc., is redefining the way consumers and businesses buy wireless services through leading product and service innovation. The Company's advanced nationwide 4G LTE network delivers outstanding wireless experiences to 67.4 million customers who are unwilling to compromise on ...
Apr. 26, 2017 02:45 AM EDT Reads: 1,011
The explosion of new web/cloud/IoT-based applications and the data they generate are transforming our world right before our eyes. In this rush to adopt these new technologies, organizations are often ignoring fundamental questions concerning who owns the data and failing to ask for permission to conduct invasive surveillance of their customers. Organizations that are not transparent about how their systems gather data telemetry without offering shared data ownership risk product rejection, regu...
Apr. 26, 2017 02:30 AM EDT Reads: 1,447
Bert Loomis was a visionary. This general session will highlight how Bert Loomis and people like him inspire us to build great things with small inventions. In their general session at 19th Cloud Expo, Harold Hannon, Architect at IBM Bluemix, and Michael O'Neill, Strategic Business Development at Nvidia, discussed the accelerating pace of AI development and how IBM Cloud and NVIDIA are partnering to bring AI capabilities to "every day," on-demand. They also reviewed two "free infrastructure" pr...
Apr. 26, 2017 01:45 AM EDT Reads: 1,316
New competitors, disruptive technologies, and growing expectations are pushing every business to both adopt and deliver new digital services. This 'Digital Transformation' demands rapid delivery and continuous iteration of new competitive services via multiple channels, which in turn demands new service delivery techniques – including DevOps. In this power panel at @DevOpsSummit 20th Cloud Expo, moderated by DevOps Conference Co-Chair Andi Mann, panelists will examine how DevOps helps to meet th...
Apr. 26, 2017 12:45 AM EDT Reads: 1,324
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...
Apr. 26, 2017 12:45 AM EDT Reads: 1,009
With billions of sensors deployed worldwide, the amount of machine-generated data will soon exceed what our networks can handle. But consumers and businesses will expect seamless experiences and real-time responsiveness. What does this mean for IoT devices and the infrastructure that supports them? More of the data will need to be handled at - or closer to - the devices themselves.
Apr. 26, 2017 12:00 AM EDT Reads: 644
Grape Up is a software company, specialized in cloud native application development and professional services related to Cloud Foundry PaaS. With five expert teams that operate in various sectors of the market across the USA and Europe, we work with a variety of customers from emerging startups to Fortune 1000 companies.
Apr. 25, 2017 11:15 PM EDT Reads: 2,318
Financial Technology has become a topic of intense interest throughout the cloud developer and enterprise IT communities. Accordingly, attendees at the upcoming 20th Cloud Expo at the Javits Center in New York, June 6-8, 2017, will find fresh new content in a new track called FinTech.
Apr. 25, 2017 11:00 PM EDT Reads: 2,343
SYS-CON Events announced today that Interoute, owner-operator of one of Europe's largest networks and a global cloud services platform, has been named "Bronze Sponsor" of SYS-CON's 20th Cloud Expo, which will take place on June 6-8, 2017 at the Javits Center in New York, New York. Interoute is the owner-operator of one of Europe's largest networks and a global cloud services platform which encompasses 12 data centers, 14 virtual data centers and 31 colocation centers, with connections to 195 add...
Apr. 25, 2017 10:30 PM EDT Reads: 1,888
DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm.
Apr. 25, 2017 10:30 PM EDT Reads: 685
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like "How is my application doing" but no id...
Apr. 25, 2017 10:30 PM EDT Reads: 7,147
The age of Digital Disruption is evolving into the next era – Digital Cohesion, an age in which applications securely self-assemble and deliver predictive services that continuously adapt to user behavior. Information from devices, sensors and applications around us will drive services seamlessly across mobile and fixed devices/infrastructure. This evolution is happening now in software defined services and secure networking. Four key drivers – Performance, Economics, Interoperability and Trust ...
Apr. 25, 2017 10:00 PM EDT Reads: 3,715
In his keynote at @ThingsExpo, Chris Matthieu, Director of IoT Engineering at Citrix and co-founder and CTO of Octoblu, focused on building an IoT platform and company. He provided a behind-the-scenes look at Octoblu's platform, business, and pivots along the way (including the Citrix acquisition of Octoblu).
Apr. 25, 2017 09:45 PM EDT Reads: 1,274


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Its amazing what can be created with an aluminum hook and a ball of string...But one of my favorite things to make with it is dishcloths. Not only are they useful and practical, you can whip them up fairly quick and they are inexpensive. The tedious job of washing dishes may seem even less so, when you are washing them with one of theses crochet dishcloths.
The Body, Mind, Heart, and Spirit of Crocheting
Filet crochet heart table runner, Again....not pinning for the pattern, but for the design. I would like a bookmark with this design on it.
DIY - Crochet bag for spring with bow http://bautawitch.se/2014/04/13/diy-virkad-vaska-till-varen-med-rosett/ ♡ Teresa Restegui http://www.pinterest.com/teretegui/ ♡
Crochet christmas wreath inspired by Lucy at Attic24
Türkranz Rettungsring 30 cm Durchmesser
Cute Koala amigurumi wreath
Häkelanleitung Türkranz " Osterzeit"

subset: commoncrawl


text:
41 891 jobs
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Development Planning jobs
There are 36,349 Development Planning-related jobs on neuvoo.co.uk. Submit your application now and get the job of your dreams.
Job Descriptions and Categories Including this search
Examples of corresponding job vacancies are Planning officer, Senior planner, Transport planner, Development management planning, Development management or Associate development planning. These jobs are often related to sectors like IT, Management, Training, Services, Customer Service or Sales.
Employment statistics
Counties with the largest quantity of job vacancies related to 'Development Planning' are England, Scotland, Wales or Northern Ireland. Cities with the highest number of search are London, Bristol, Manchester, Birmingham, Leeds or Glasgow.
Top Employers Offering Development Planning Jobs
Employers with the most Development Planning-related jobs are Prince Personnel Ltd, Create Your Own Career, Maclean Moore Consulting, Ridge and Partners LLP, Badenoch & Clark - Manchester. or LIVE Experiences Ltd.
neuvoo.co.uk: the the largest job board across the United Kingdom
neuvoo.co.uk is the biggest job site in the UK with over 701981 job vacancies available, 36,349 of which are Development Planning-related.Show more...
G2 Recruitment Solutions Limited |
(Unspecified city)
- 15h ago
My client is currently seeking a motivated Planning Officer to join a busy Development Management team... The ideal candidate will have a strong knowledge of local planning procedures, be a member of the RTPI...
Penguin Recruitment |
London, England
- 15h ago
Assistant Transport Planner (development planning). London, Central London. 25,000. 30,000... An independent transport planning & highway design consultancy based in London are recruiting for an...
Panoramic Associates |
(Unspecified city)
- 15h ago
Job opportunity. Senior RTPI Planning and Development Officer (day rate dependant on experience). Our Public sector client based in the North West of the country is looking for an experienced...
Penguin Recruitment |
London, England
- 1d ago
Transport Planner (development planning). London, Central London. 25,000. 30,000. An independent... The organisation provide specialist development planning services for their clientele across the UK and...
Hays |
London, England
- 1d ago
They have a large planning team and they are currently looking for a experience mid level DM planner to... ..term contract with flexible working and a great opportunity to work on some large developments...
(Unspecified city), England
- 15d ago
AECOM. We have a number of exciting opportunities across the UK for trainees to work within our Development Teams. The Development team is focused on the planning and delivery of development...
Plymouth, England
- 13d ago
AECOM. We have a number of exciting opportunities across the UK for trainees to work within our Development Teams. The Development team is focused on the planning and delivery of development...
G2 Recruitment Solutions |
(Unspecified city)
- 5d ago
Summary. My client is currently seeking a motivated Planning Officer to join a busy Development... The ideal candidate will have a strong knowledge of local planning procedures, be a member of the RTPI...
(Unspecified city), England
- 1d ago
Job Summary Our Environment and Planning team are seeking to recruit a planning consultant at Senior... We work across the development sectors delivering projects of varying scale and complexity and have a...
Carbon60 Limited |
Brighton, England
- 14d ago
Responsible for a complex work programme of planning related activities and enquiries working flexibly... the development and implementation of planning conservation policies and plans and evidence in regard to...
Edelman |
- 1d ago
Description. The Planning team at Edelman acts as a centre of excellence and internal consultants... Our contribution takes the form of. Campaign development. through identifying the territory which powers...
Aberdeen City Council |
Aberdeen, Scotland
- 14h ago
Job Purpose. Support the design, development and implementation of Aberdeen Community Planning... This includes coordinating the delivery of a wide range of development opportunities which build the...
Search Consultancy |
Uxbridge, England
- 14d ago
Here you will be involved in growing an already successful Planning team that sit within a very well... You will be ambitious and thrive on business development and marketing and be looking for a culture that...
Ackerman Pierce Ltd |
Cheshire, England
- 15h ago
Planning Officer. Cheshire. My client is looking for a Planning Officer to join their Development... The suitable candidate for the role will be responsible for achieving quality planning outcomes and...
Appoint Group |
- 7h ago
Job Title. Principal Consultant ( Development Transport Planning ) Location. London Salary. 45K... 5K. 49K About Us We provide specialist development planning advice to the development industry and...
Fircroft Engineering Serv Ltd (Contract) |
Darlington, England
- 3h ago
The Role Responsible for leading the Planning Team and to developing. maintaining Planning systems... Responsible for the Implementation, Development and Maintenance of the company wide Planning system...
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이 아이디어와 더 많은 아이디어를 탐색하세요!
관련 주제 탐색하기
If Yayoi Kusama was born into this generation, would she be into the health goth look instead?
saving up for a whole new wardrobe, this stuff will definitely be in it! :D
Yes, Asian Street Fashion
.//❂ shhayleigh ❂\\.
Fishnet tights an jeans ( Cute combination )
AUTOMNE VESTE MANIA by Modalist. https://www.mymodalist.com/modmag/automne-veste-mania/
Grunge fashion
brown combat boots- I already have a pair of black Doc Martens and I wish I had a pair of brown combat boots because they are less harsh and would be perfect with summer dresses.


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Johnsonville sausage recipes
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Smoked Sausage and Cheesy Orzo!- Make this tonight with Johnsonville Smoked Sausage.
One Pan Cheesy Smoked Sausage & Pasta Recipe | Budget Savvy Diva-- Make this with your favorite Smoked Johnsonville Sausage.
This Dirty Rice made with Johnsonville Hot Italian Sausage is the perfect addition to your Fat Tuesday Celebration!
Best meal for a cold winters day! Easy to make and the whole house smells amazing! Italian Sausage Bake from KatiesCucina.com. Try this recipe with Johnsonville Sausage!
Southern Sausage Spaghetti Sauce made with Johnsonville Sausage #ad #SausageSunday
Oven Roasted Smoked Sausage Potatoes Recipe ~ easy, simple and delicious. Make this recipe with your favorite Johnsonville Smoked Sausage!
Skillet Pasta with Sausage - this one pan meal is ready in no time at all and your family will love it!
Spicy Smoked Sausage Alfredo Bake Recipe | This easy pasta recipe is ready in less than 30 minutes!
Sausage and Spinach Alfredo- make this recipe with Johnsonville Andouille Sausage!
Italian Sausage Lasagna- Up your lasagna game with Johnsonville Sausage. It's a simple, delicious dish that your whole family will enjoy!


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R.I.P. Chuck Berry
I have published an amazon kindle book about Obamacare
I have published an amazon kindle book about Obamacare.
You can buy it at
You can read it for free at
I just added four new items to my list of Obamacare criticisms
The complete list can be found at https://danfromsquirrelhill.wordpress.com/2013/09/24/obamacare-59/
Here are the new entries:
338) After Obamacare caused Obama supporting graduate students at the University of Missouri to lose their insurance, they falsely blamed it on the school
In August 2015, the University of Missouri issued the following message to its graduate students:
"The Affordable Care Act prevents employers from giving employees money specifically so they can buy health insurance on the individual market. Graduate teaching and research assistants are classified as employees by the IRS, so they fall under this ruling."
However, in November 2015, left wing graduate students who had voted for Obama, falsely blamed their loss of insurance on the school, instead of on Obamacare.
339) A federal judge ruled that some of the funding for Obamacare was unconstitutional
In May 2016, U.S. District Court Judge Rosemary Collyer ruled that some of the funding for Obamacare was unconstitutional, because it had not been approved by Congress.
340) Obama falsely said that opponents of Obamacare did not have a plan to replace it
In November 2016, when talking about Republican opponents of Obamacare, Obama said:
"You watch the press conference and you realize, they got no plan… It's not like, they don't even have a pretense of a plan. They don't even have a semblance of a plan. Not even a hint of a plan. Not even a remote — not even a — there's no plan. Nothing, zero, nada. You can't just be against something. You gotta be for something."
However, several months earlier, in June 2016, the Republicans had announced this plan to replace Obamacare.
341) Obama falsely said that none of the predictions that were made by Obamacare opponents came true
In November 2016, when talking about predictions made by Obamacare opponents, Obama said:
"None of what they said has happened."
However, in the real world, Obamacare opponents accurately predicted that Obamacare would cause millions of people to lose their insurance.
6-year-old gave up birthday party to feed the homeless instead
6-year-old gave up birthday party to feed the homeless instead
March 12, 2016
One Chicago kindergartner wanted to feed the homeless instead of throw a birthday party.
Armani Crews, who turned 6 earlier this month, had been begging her parents for "a few months" to feed homeless people in her community, but her parents thought "she was joking," her mother, Artesha Crews, told ABC News.
"I said, 'OK, we'll make some sandwiches,' to which Armani said, 'No. I want the same thing we'd have at my birthday party,'" her mother recalled.
Even when her father, Antoine, informed her that if she wanted to go through with this, she wouldn't get a birthday gift, the girl, whose birthday was March 5, persisted.
So the Chicago family spent about $300 buying food to deliver to homeless people in the city's East Garfield Park neighborhood. They purchased chicken, fish, spaghetti, corn, green beans, mashed potatoes, rolls, cake, cookies, fruit and water.
After Armani mentioned her plan at the family's local church, congregation members donated other items to create care packages for the homeless.
Each care package included a toothbrush, toothpaste, deodorant, hand sanitizer and a snack, such as a granola bar.
Armani's birthday party was a success, with the family feeding more than 125 people who gathered.
In a statement, the kindergarten student told ABC News, "It was nice to be nice."
Her mother added, "She was excited. She was happy. Everybody was being fed. …One of the gentleman said he hadn't had a hot meal in a long time."
Now the 6-year-old wants to host another community meal for the homeless. Her mother said the family plans to return to the park "within the next couple of weeks."
Here's another reason not to attend UC Berkeley, but this one has nothing to do with politics
In this seven minute video, a physiology (a branch of biology) major at UC Berkeley says that one of her classes had 700 students, there were not enough chairs, she had to stand behind the professor, and so she could not see what the professor was showing on the overhead projector.
Iraqi-funded Muslim spy who worked for U.S. House Democrats had Debbie Wasserman Schultz's email password
The trouble in this new scandal just keeps getting deeper and deeper.
About five weeks ago, it was reported that dozens of Democrats in the U.S. House of Representatives had allowed four Muslim spies to have access to sensitive security information that they weren't legally authorized to see, and had paid each of them a salary of $160,000 a year. The Democrats had ignored various red flags, such as their shady real estate dealings, massive amounts of debt, and criminal activities, because they did not want to be accused of "Islamophobia." You can read about it here and here.
Then about two weeks later, we were given an update with new information: at the same time that these House Democrats allowed these Muslim spies to steal U.S. security secrets and paid them salaries of $160,000 a year, these Muslim spies accepted a $100,000 payment from an Iraqi politician. And again, these House Democrats looked the other way, because they did not want to be accused of "Islamophobia."
Now we have another update with more new information: one of these Muslim spies had Debbie Wasserman Schultz's email password at the same time that the hacked DNC emails were given to WikiLeaks. And yet again, these House Democrats looked the other way, because they did not want to be accused of "Islamophobia."
Shame on Rand Paul and 22 other Republican U.S. Senators for wanting to let corporations sell people's private internet history!
Shame on Rand Paul and 22 other Republican U.S. Senators for wanting to let corporations sell people's private internet history!
These are the 23 Senators that introduced a bill to let telecoms sell your private internet history
March 8, 2017
Protection of your Internet history is up in the air thanks to new, pending legislation. A new bill coming before Senate aims to completely dismantle the FCC's ability to enact data security or online privacy protections for consumers under the powers of the Congressional Review Act. Senate Joint Resolution (S.J.Res 34) was introduced by Arizona Senator Jeff Flake and cosponsored by 23 other Senators. Its goal is to remove all the hard-earned net neutrality regulations gained to protect your internet history from advertisers and and worse. Specifically, the FCC had been able to prevent internet service providers (ISPs) from spying on your internet history, and selling what they gathered, without express permission. This legal protection on your internet history is currently under attack thanks to these 23 Senators and lots of ISP lobbying spend. While S.J.Res 34 has support from two dozen Republican Senators, Senators willing to champion the privacy of Americans' internet history have also come out of the woodwork.
These 23 Senators want to let your internet history be sold.
The list of 23 Senators cosponsoring this bill, including Senator Jeff Flake, is:
– John Barrasso (R-Wyo.)
– Jeff Flake (R-Ariz.)
– Roy Blunt (R-Mo.)
– John Boozman (R-Ark.)
– Shelly Moore Capito (R-W.Va.)
– Thad Cochran (R-Miss.)
– John Cornyn (R-Texas)
– Tom Cotton (R-Ark.)
– Ted Cruz (R-Texas)
– Deb Fischer (R-Neb.)
– Orrin Hatch (R-Utah)
– Dean Heller (R-Nev.)
– James Inhofe (R-Okla.)
– Ron Johnson (R-Wisc.)
– Mike Lee (R-Utah)
– Rand Paul (R-Ky.)
– Pat Roberts (R-Kan.)
– Marco Rubio (R-Fla.)
– Richard Shelby (R-Ala.)
– Dan Sullivan (R-Ark.)
– John Thune (R-S.D.)
– Roger Wicker (R-Miss.)
– Jerry Moran (R-Kan.)
Nancy Pelosi's recent statement shows a complete lack of logic
We can always count on Nancy Pelosi to provide us with humor and entertainment as she, time and time again, displays proof that she is bat guano insane.
For her latest display, Breitbart reports:
Pelosi: 'I Would Have Been Gone By Now' If Hillary Had Won
While speaking with reporters on Friday, House Minority Leader Representative Nancy Pelosi stated of the 2016 presidential election, "I would have been gone by now if she had won."
Pelosi said that the Affordable Care Act is "a pillar" and that if Clinton was in office, she wouldn't worry about the ACA going away. Pelosi continued that "we all knew" Clinton would win.
She added that Trump winning "motivated me her to stay." And "I would have been gone by now if she had won."
So, here are the facts, according Pelosi:
1) Pelosi "knew" that Hillary Clinton would win the election.
2) If Clinton won the election, Pelosi would no longer stay in the U.S. House of Representatives.
3) Pelosi ran for reelection.
See the contradiction there? If Pelosi "knew" that Clinton would win, and if Clinton winning would mean that Pelosi would no longer be in the House, then why did Pelosi run for reelection in the first place?
If everything that Pelosi had said was true – i.e., if she truly believed that Clinton would win, and if Clinton winning would mean that Pelosi would no longer be a member of the U.S. House – then Pelosi would not have run for reelection.
But she did run for reelection.
Therefore, her statement is completely lacking in logic.
Note to Ben Carson bashers: when Obama called slaves 'immigrants,' you showered him with praise
Hypocrite liberal women are accepting money from men, to prove that women don't need money from men
Recently on Interstate 40 between Winston-Salem and Greensboro in North Carolina, an anonymous party paid to have a billboard put up which says "Real men provide. Real women appreciate it."
Here's a photograph of the billboard (which comes form this website, and which I am showing under fair use):
Two women who disagree with the message on the billboard – Paula Atwood and Kathryn Rende – have set up this GoFundMe page to raise money to put up a billboard with their own message to counter the message on the original billboard.
However, according to the the list of people who have donated to their fundraiser, these two women, who are trying to disprove the claim that "real men provide – real women appreciate it," are themselves accepting and appreciating money from men.
So while the intent of these two women was to disprove the claim that was made on the original billboard, the actual result of their actions was that they ended up reinforcing the claim.
Video: Democrats groan when Trump announces office to help victims of immigrant crime
Democrats Groan When Trump Announces Office To Help Victims Of Immigrant Crime
February 28, 2017
Democratic lawmakers let their opposition be known Tuesday to President Trump's plan to open an office aimed at helping the victims of crimes committed by immigrants.
Democrats groaned loudly when Trump announced the creation of Victims of Immigration Crime Engagement (VOICE), an office which will fall under the purview of the Department of Homeland Security.
"I have ordered the Department of Homeland Security to create an office to serve American Victims. The office is called VOICE –- Victims Of Immigration Crime Engagement. We are providing a voice to those who have been ignored by our media, and silenced by special interests," said Trump.
A chorus of groans rippled through the audience at the joint session of Congress.
Trump then introduced the families of several people who have been killed by illegal immigrants in the U.S.
In Japan, Muslim protestors demand the execution of anyone who criticizes their religion


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Supervision 101 (Kauai)
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When it comes to legally challenging tech giants, Aaron Greenspan is on a roll. In March, he won a small claims court suit against Google's AdSense program, which cut him off without warning and without paying him what his site had earned.
It turns out that Greenspan attended Harvard at the same time Facebook founder Mark Zuckerberg did. Greenspan developed a network for the Harvard community called houseSYSTEM. The network included course scheduler, student marketplace, email service, automatic birthday reminder, message boards, photo album, digital flyer advertising, event calendar (with online RSVP's), map integration, job placement, and local business reviews. Greenspan thought about adding profiles, but at the time nixed them for security reasons.
houseSYSTEM included a section called 'The Universal Face Book.'
Later, Zuckerberg would add profiles when he started his social network in 2004. And, of course, he called it Facebook.
Naturally, this led to trademark disputes which have now been settled.
This isn't the first time a classmate of Zuckerberg wanted credit for their Harvard-era work. ConnectU's co-founders (and twins) Cameron and Tyler Winklevoss, along with co-founder Divya Narendra sued Facebook for idea-stealing. That case was settled as well, with leaked reports purpotedly showing the settlement money in the $65 million range.
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Joseph Stolarick — Audio Documentarian
Joe Stolarick is a New Orleans-based audio engineer and musician. Originally from Schuylkill County, Pennsylvania, Joe first visited New Orleans in 2010 as a member of AmeriCorps and permanently relocated in 2012.
He now works as Audio-Visual Production Specialist for the Louisiana State Museum, recording, mixing, and documenting concerts and special events held at the Old U.S. Mint's Performing Arts Center. He also supports digitization of the LSM's internationally recognized Jazz Collection and other recorded media.
In addition to his work for the Louisiana State Museum, Joe freelances as an audio engineer and producer, frequently partnering with the New Orleans Jazz National Historical Park and WWOZ New Orleans 90.7 FM. His recordings have been featured on numerous public radio programs including American Routes with Nick Spitzer, Talkin' Jazz with Fred Kasten, and Music Inside Out with Gwen Thompkins.
An accomplished percussionist, Joe performs and records regularly with the New Orleans Jazz National Historical Park band. He has also shared the stage with many local musicians including Bruce "Sunpie" Barnes, the Panorama Jazz Band, and Kelcy Mae
Joe earned his B.A. in Music with an emphasis in Music Recording Technology and Percussion from Lebanon Valley College (Annville, PA) in 2008. In 2007, he completed an audio production internship at Smithsonian Folkways Recordings in Washington D.C. After graduation, Joe worked as Assistant Engineer at George Blood Audio/Safe Sound Archive, an audio preservation facility located in Philadelphia, PA.
Field and sound recordings that Joe recorded during the 2014 Birdfoot Festival can be heard on his SoundCloud site.


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Chronic, excessive ethanol intake can increase retinoic acid (RA) catabolism by inducing cytochrome P450 2E1 (CYP2E1). Vitamin E (VE) is an antioxidant implicated in CYP2E1 inhibition. In the current study, we hypothesized that VE supplementation inhibits CYP2E1 and decreases RA catabolism, thereby preventing ethanol-induced hepatocyte hyperproliferation. For 1 month, four groups of Sprague-Dawley rats were fed a Lieber-DeCarli liquid ethanol (36% of the total calories) diet as follows: either ethanol alone (Alc group) or ethanol in combination with 0.1 mg/kg body wt of all-trans RA (Alc+RA group), 2 mg/kg body wt of VE (Alc+VE group), or both together (Alc+RA+VE group). Control rats were pair-fed a liquid diet with an isocaloric amount of maltodextrin instead of ethanol. The ethanol-fed groups had three-fold higher hepatic CYP2E1 levels, 50% lower hepatic RA levels, and significantly increased hepatocyte proliferation when compared with the controls. The ethanol-fed rats given VE had more than four-fold higher hepatic VE concentrations than did ethanol-fed rats without VE, but this did not prevent ethanol induction of CYP2E1, lower hepatic retinoid levels, or hepatocellular hyperproliferation. Further, VE supplementation could not prevent RA catabolism in liver microsomal fractions of the ethanol-fed rats in vitro. These results show that VE supplementation can neither inhibit ethanol-induced changes in RA catabolism nor prevent ethanol-induced hepatocyte hyperproliferation in the rat liver.
Chronic, excessive ethanol intake increases the risk of developing various liver diseases such as cirrhosis and cancer, and an early and key characteristic in the pathogenesis of ethanol-induced liver injury is hepatocyte hyperproliferation [1-2]. One suggested mechanism by which ethanol induces hepatic cell proliferation involves the interference of ethanol with retinoid (retinol, retinoic acid, and retinyl ester) metabolism and signaling [3]. Lower hepatic vitamin A (retinol and retinyl ester) levels have been well documented in alcoholics [4]. Moreover, both plasma and hepatic concentrations of retinoic acid (RA), the most physiologically active retinoid, are significantly decreased in rats after 1 month of ethanol feeding [5]. RA, which functions as a ligand for the nuclear retinoid receptors (RARs and RXRs), plays an important role in controlling cell cycle progression, thereby regulating cell proliferation and differentiation [6]. Indeed, RA is of clinical interest for use in cancer chemoprevention and treatment, and retinoids have been shown to be effective against acute promyelocytic leukemia, skin cancer, and breast cancer [7-9]. Previous studies in our laboratory have demonstrated that ethanol-induced hepatocyte hyperproliferation can be prevented by RA supplementation [1, 10], indicating that low levels of retinoids could be an important factor in ethanol-induced chronic liver diseases.
Increased oxidative stress, which occurs in the liver as a result of chronic ethanol intake [11], could also contribute to pathogenic alterations in hepatic cells, including hyperproliferation. Vitamin E (VE) is a potent antioxidant and has been shown to effectively decrease in vitro and in vivo susceptibility to lipid peroxidation [12-14]. Research has documented synergistic interactions between vitamins A and E against lipid peroxidation in vitro, with the combination offering reciprocal protection against oxidation [15].
The generation of reactive oxygen species and oxidative stress by ethanol in the liver appears to be mediated mainly by the induction of cytochrome P450 2E1 (CYP2E1). CYP2E1 is highly reactive in oxidizing various substrates and producing free radicals, and the hepatic content of CYP2E1 is significantly increased in alcoholics and rats fed an ethanol diet [16,17]. The CYP2E1 induction in the liver of ethanol-fed rats closely coincides with the production of 1-hydroxyethyl radicals [18]. Moreover, transgenic mice that overexpress CYP2E1 are more susceptible to oxidative liver injury after ethanol treatment than nontransgenic controls [19]. CYP2E1 has been shown to play a major role in depleting liver RA stores by facilitating RA degradation into polar metabolites [20]. Further, treatment with chlormethiazole, a CYP2E1 inhibitor, effectively inhibits liver pathology in ethanol-fed rats [21] and restores hepatic RA and retinol levels to normal [20, 22], thus providing evidence that CYP2E1-mediated reactions are likely to contribute to ethanol-related liver injury. Administration of a VE analogue, the tris salt of α-tocopheryl hemisuccinate, to rats has been shown to decrease CYP2E1 activity and protect against CCl4-induced hepatotoxicity [23]. Therefore, we hypothesized that VE supplementation could prevent ethanol-related alterations in the liver, such as CYP2E1 induction, decreased RA concentrations, or increased cellular proliferation. To test this hypothesis, we investigated the effects of dietary VE supplementation, with or without RA, on hepatic retinoid concentrations, CYP2E1 levels, RA oxidation to polar metabolites, and hepatocyte proliferation in rat liver tissues after 1-month of ethanol feeding.
Twenty-five male Sprague-Dawley rats (Charles River Breeding Laboratory, Kingston, NY) were provided free access to Teklad 7012 rodent meal (Harlan Teklad, Madison, WI) and water for a 1-week acclimation period. Subsequently, all animals were fed a Lieber-DeCarli liquid diet (Dyets, Inc., Bethlehem, PA) without ethanol for five days. Animals were then distributed, by wt-matching, into five groups: 1) control [C]; 2) ethanol-fed [Alc]; 3) ethanol-fed with all-transRA (0.1 mg/kg body wt) supplementation [Alc+RA]; 4) ethanol-fed with vitamin E (2 mg/kg body wt) supplementation [Alc+VE]; or (5) ethanol-fed with both all-trans-RA and vitamin E supplementation [Alc+RA+VE]. Ethanol was fed with the Lieber-DeCarli liquid diet containing 36% of total calories as ethanol, yielding a concentration of 6.2% (vol/vol) [24]. Ethanol was gradually introduced into the experimental diets over a 10-day period before providing animals with the final concentration. Control animals were maintained on the Lieber-DeCarli liquid diet without ethanol. In the control diet, ethanol was replaced by an isocaloric amount of maltodextrin (Purina Test diets, Richmond, IN). Both diets contained 16.4% of total calories as protein and 35% as fat; 48.6% of total calories were provided from carbohydrates in the control diet, whereas 12.6% of total calories were from carbohydrates in the ethanol diet. The dosage of RA supplementation was determined based on the data from our previous study in ethanol-fed rats [1], which showed that RA supplementation at the dose of 0.1 mg/kg body wt/day restored hepatic RA concentrations similar to those of control rats. In addition, there was no evidence of toxicity as determined by lack of changes in wt gain or liver histology. The dosage of vitamin E supplementation was determined based on the data from a previous study by Chow et al. [25], which showed that 2 mg vitamin E supplementation (/kg body wt/day) significantly increased the levels of vitamin E in tissues. For RA supplementation, all-trans-RA (Sigma, St. Louis, MO) was dissolved in 95% ethanol. Then, the precise concentration of the RA stock solution was determined by spectral analyses and the appropriate volume of the RA stock solution was directly added into the liquid diet. For VE supplementation, α-tocopherol acetate (Hoffmann-La Roche Ltd, Basel, Switzerland) was dissolved in corn oil and mixed with the liquid diet. To protect from degradation, the stock solutions of RA and VE were filled with nitrogen gas and stored in colored tubes at 4°C. The liquid diet was made fresh every two to three day and stored in colored bottles at 4°C. Since the liquid diet provided physiological amounts of fluid, extra water was not given. Rats were pair-fed using Alc+RA+VE as the leading group for one month. Body wts were recorded weekly. At the end of experimental period, all rats were terminally exsanguinated under AErrane® (Fort Dodge Animal Health, Fort Dodge, IO) anesthesia. Liver tissues were collected, frozen under liquid nitrogen, and stored at − 80°C for further analysis.
All animals were maintained in an American Association for the Accreditation of Laboratory Animal Care accredited facility, in an environmentally controlled atmosphere (temperature, 23°C, 45% relative humidity) with 15 air changes of 100% fresh filtered air per hour and a 12/12h light/dark cycle. All animals were observed daily for clinical signs of illness. This study protocol was approved by the Jean Mayer USDA Human Nutrition Research Center on Aging Animal Care and Use Committee.
Liver sample extractions were done as described previously [1]. Briefly, liver tissue was homogenized with ice-cold HEPES buffer:methanol (2:1, vol/vol) mixture. After adding the internal standard (100 μL of retinyl acetate), liver samples were extracted twice without saponification using 6.0 ml of chloroform:methanol (2:1, vol/vol) mixture followed by hexane. The extracts were evaporated under N2 gas, and resuspended in 50 μL ethanol for injection into the HPLC system. A gradient reverse phase HPLC system was used as follows: flow rate was 1 mL/min; 10% solvent A (acetonitrile:tetrahydrofuran:water = 50:20:30, vol/vol/vol, with 0.35% acetic acid and 1% ammonium acetate in water) for 3 minutes, followed by a 6-minute linear gradient to 40% solvent A and 60% solvent B (acetonitrile: tetrahydrofuran: water = 50:44:6, vol/vol/vol, with 0.35% acetic acid and 1% ammonium acetate in water), a 12-minute hold at 40% solvent A/60% solvent B, and then a 7-minute gradient back to 100% solvent A. Individual retinoids and α-tocopherol were identified by co-elution with standards and absorption spectrum analysis, and quantified by determining peak areas calibrated against known amounts of standards. Levels were corrected for extraction and handling losses by monitoring the recovery of the internal standard.
Western blot analysis was carried out as described earlier [26]. Protein was transferred onto polyvinylidene diflouride membranes, which were incubated with polyclonal antibody against CYP2E1 (Chemicon International Inc, Temecula, CA) at a 1:200 dilution in Tris-buffered saline-Tween 20 (TBS-T) buffer at room temperature for 2-3 hours. The membranes were then washed and incubated for 1 hour in TBS-T buffer containing a 1:5000 dilution of the horseradish peroxidase-labeled secondary antibody (Bio-Rad, Hercules, CA). The blots were developed using the ECL Western blotting system (Amersham, Piscataway, NJ) and analyzed by densitometry (Bio-Rad model 710). The equal loadings of proteins were verified by checking that the intensities of non-specific bands were the same among wells. All samples in each pair-feeding group were run on the same blot. The band intensities of samples in four treatment groups were compared to the band intensity of a control sample on the same blot, and expressed as fold increase compared with the control.
Hepatocytes in the S phase were quantified by immunohistochemical analysis of proliferating cellular nuclear antigen (PCNA) as described earlier [1]. Briefly, liver samples were fixed with 10% buffered formalin and embedded in paraffin wax. After deparaffinization and rehydration, the liver sections were incubated with 3% H2O2 to quench endogenous peroxide activity, and the slides were heated in 10 mM citrate buffer to retrieve the antigen. The slides were then blocked with horse serum and incubated with the primary antibody, monoclonal anti-PCNA (clone PC10, Dako, Carpinteria, CA), and then with the biotinylated horse anti-mouse immunoglobulin G and streptavidin conjugated to a horseradish peroxidase label. Slides were developed using DAB (diaminobenzidine) substrate and counterstained with hematoxylin. Hepatocytes with dark brown stained nuclei and cytoplasm were counted as S phase cells. The investigators were blinded, and the cells were viewed under X400 magnification. A total of 20 fields were counted and S phase cells were expressed as positive cells per 100 hepatocytes.
Hepatic microsomal protein (2 mg) was incubated under red light in glass vials at 37°C in a shaking water bath for a 3-min preincubation with the following additions: buffer [Hepes, 20 mmol/L; KCl, 150 mmol/L; MgCl2, 5 mmol/L; EDTA, 1 mmol/L (pH, 7.35)] and substrate (RA dissolved in dimethyl sulfoxide, 5 nmol) in a final volume of 1 mL. The incubation mixtures were preincubated with either α-tocopherol or CYP inhibitors (chlormethiazole for CYP2E1, and liarozole for nonspecific CYP) for 10 min before incubation. After preincubation, the reaction was started by adding NADPH (1 mmol/L) and the mixtures were incubated for 10 min at 37°C. Two control vials were run lacking either substrate or microsomes. The vials were uncovered and the incubation mixtures were exposed to room air as the gas phase. After incubation, RA and its polar metabolites were extracted and analyzed by the method described previously [20]. Individual retinoids (4-oxo-RA, 18-hydroxy-RA, RA) were identified by coelution with standards and absorption spectrum analysis. Retinoids were quantified relative to the internal standard (retinyl acetate), by determining peak areas calibrated against known amounts of standards.
All group values are expressed means ± standard deviation. Group means were compared using analysis of variance (ANOVA) followed by Tukey's Honest Significant Difference test. All analyses were performed using the SAS software version 9.1 (SAS Institute Inc, Cary NC). Significance of difference was determined at P <0.05.
No significant differences were observed in the body wt after 1 month of alcohol feeding and supplementation with RA, VE, or both. The final mean body wt of the rats in each group was as follows: Alc, 256 ± 6 g; Alc+RA, 228 ± 13 g; Alc+VE, 225 ± 8 g; and Alc+RA+VE, 223 ± 9 g. The wt of the control rats at the end of the study was 237 ± 4 g.
The hepatic VE concentration was slightly lower in the ethanol-fed rats than in the controls, but this change did not reach statistical significance (Table 1). The ethanol-fed rats given a VE supplement, with or without RA, had hepatic VE concentrations more than four-fold higher than the animals given alcohol alone and three-fold higher than the control rats. Ethanol feeding for 1 month resulted in approximately 50% lower hepatic RA concentrations in these rats than in the controls, and VE supplementation alone could not prevent this decline (Table 1). However, RA treatment, alone or with VE, resulted in hepatic RA concentrations in the ethanol-fed rats that were not significantly different from those in the control animals. There were no differences in the hepatic retinol concentrations among the groups except in the Alc+RA+VE group, where the hepatic retinol levels were significantly higher than in the rest of the ethanol-fed groups (Table 1). Concentrations of retinyl palmitate were 71% lower in the ethanol-fed animals that in the controls (Table 1). Hepatic retinyl palmitate concentrations were slightly higher in the Alc+RA and Alc+VE groups than in the Alc group, but these differences were not significant. However, the hepatic retinyl palmitate concentrations in the ethanol-fed rats cotreated with RA and VE were closer to the levels in the control animals.
Hepatic CYP2E1 levels were approximately three-fold higher in the ethanol-fed rats than in the controls. VE supplementation, with or without RA, did not affect the expression of hepatic CYP2E1 when compared with ethanol feeding alone (Figure 1).
The effect of ethanol, RA, and VE supplementation for a 1-month period on hepatocyte proliferation was assessed by immunohistochemical staining of liver tissue for PCNA (Figure 2). Liver sections from the ethanol-fed rats had a significantly higher number of PCNA-labeled hepatocytes than the rats fed the control diet. The groups receiving RA treatment, with or without VE, had markedly lower numbers of PCNA-positive hepatocytes than the rats fed alcohol alone (p < 0.05). In the ethanol-fed rats, VE supplementation alone did not result in a lower number of positively stained hepatocytes than by ethanol feeding alone.
The effects of ethanol, VE, and CYP2E1 inhibitors on RA catabolism were examined by quantification of polar oxidative metabolites of RA, namely, 4-oxo-retinoic acid (4-oxo-RA) and 18-hydroxy-retinoic acid (18-hydroxy-RA), after incubation of liver microsomal fractions from various groups with 5 mmol/L RA (Table 2). The ethanol-fed rats had significantly higher levels of 4-oxo-RA and 18-hydroxy-RA (eight-fold and six-fold higher, respectively) than the controls. Neither in vivo VE supplementation nor exogenous VE addition to the incubation mixture had any protective effect against ethanol-induced vitamin A catabolism. On the other hand, addition of liazarole, a non-specific CYP enzyme inhibitor, to the incubation mixture resulted in significantly lower levels of 4-oxo-RA and 18-hydroxy-RA compared with the levels in both ethanol-fed (>90% reduction) and control (~50% reduction) animals. Addition of chlormethiazole, a specific inhibitor of CYP2E1, to the incubation mixture resulted in lower levels of vitamin A polar metabolites than those achieved with ethanol feeding alone (~50% reduction); however, the 4-oxo-RA and 18-hydroxy-RA levels were still significantly higher than the levels in the controls.
Chronic, excessive ethanol consumption can lead to increased RA degradation to polar metabolites, largely due to oxidative metabolism by CYP2E1 [20]. In the present study, we hypothesized that VE prevents alcohol-reduced RA concentrations by blocking CYP2E1 activity, thereby preventing alcohol-induced hepatocyte hyperproliferation. As observed in our previous studies [1, 10], chronic ethanol intake in rats significantly decreased the hepatic RA concentrations, induced CYP2E1, and increased hepatocyte hyperproliferation. The hepatic VE level in the ethanol-fed rats was 36% lower than in the pair-fed controls. Although the difference was not statistically significant, these data are in agreement with the results of previous studies, which showed that the hepatic VE concentrations were 25-38% lower in ethanol-fed rats than in control rats [27, 28]. Low levels of VE in the liver have also been reported in patients with alcoholic cirrhosis [29]. Mechanisms that may lead to reduced hepatic levels of VE by ethanol include increased degradation of VE via ethanol-induced free radical formation and lipid peroxidation [30], and malabsorption resulting from β-lipoprotein deficiency [31]. Further, Meydani and colleagues [32] observed that chronic ethanol feeding of rats significantly decreased the hepatic VE level when expressed as per milligram of total lipid but not when expressed as per milligram of tissue, indicating ethanol-induced redistribution of VE in hepatic tissue.
In the ethanol-fed rats, although VE supplementation at a dose of 2 mg/kg body wt resulted in significantly higher hepatic VE concentrations, than without VE supplementation, the hepatic RA levels were not affected by the supplementation, and no significant difference was observed in the hepatocyte proliferation rate between the ethanol-fed rats with and without VE supplementation. Consistent with these findings is the fact that the CYP2E1 levels were higher in all the alcohol-fed animals than in the controls, despite VE supplementation in two groups. In addition, the data from our in vitro incubation studies support the lack of a VE effect on RA metabolism. Neither in vivo VE supplementation nor exogenous VE addition to the incubation mixture had any protective effect against ethanol-induced RA catabolism in the liver microsomal fractions. We confirmed that liazarole, a nonspecific CYP enzyme inhibitor, completely prevented ethanol-induced catabolism of vitamin A; in fact, it also seemed to partially inhibit basal catabolism of vitamin A. Chlormethiazole, a specific inhibitor of CYP2E1, partially inhibited ethanol-induced catabolism of vitamin A. This result suggests that although CYP2E1 is the major CYP enzyme induced by chronic ethanol feeding [33], there are probably additional enzymes induced by ethanol that contribute to the oxidative catabolism of vitamin A. For example, the family of CYP26 enzymes was shown to metabolize RA [34-36]. Taken together, above data confirm that CYP inhibition, and inhibition of CYP2E1 particularly, can prevent ethanol-induced catabolism of vitamin A to polar metabolites but suggest that the effects are not achieved by VE supplementation.
Our results are in contrast to several reports regarding the protective effect of VE in other tissues of ethanol-treated animals, including prevention of ethanol-induced hyperregeneration of colon crypt cells in rats [37] and inhibition of a promotional effect of ethanol on chemically induced esophageal cancers with dietary VE supplementation [38]. This suggests that the effect of VE on cell proliferation may vary depending on the organ or cell type. For example, VE enhances ethanol-suppressed splenocyte proliferation but not thymocyte proliferation [39].
In contrast, RA supplementation of the ethanol-fed rats restored the ethanol-reduced hepatic RA levels and was correlated with decreased hepatocyte proliferation. Interestingly, slightly higher hepatic concentrations of RA and slightly lower levels of hepatocyte proliferation were achieved with VE and RA co-supplementation than with RA supplementation alone. Although these differences did not reach statistical significance, they suggest a potentially useful interaction between these two nutrients, which deserves further study. Our study is limited by relatively small number of animals in each treatment group. Further, studies with several doses or different ratios of VE and RA combinations are needed. Nevertheless, our data demonstrated that supplementing RA and VE together partially restored both retinol and retinyl palmitate levels in ethanol-fed rats, whereas RA or VE alone had little effect. RA has been shown to regulate retinoid metabolism in the liver by stimulating retinol esterification [40,41]. It may be that the regulatory effect of RA in ethanol-fed rats can be enhanced in the presence of VE, although the mechanism for this effect needs further investigation.
Taken together, our data support the concept of RA as a key regulator of hepatocyte proliferation. VE supplementation, however, does not protect against ethanol-induced CYP2E1 induction, RA catabolism, or hepatocyte hyperproliferation in vivo. VE supplementation, in conjunction with RA, appears to improve ethanol-induced alterations in retinoid metabolism, but the difference was not statistically significant. Further studies are warranted to fully understand the potential beneficial role of the VE and RA combinations in preventing ethanol-induced changes in retinoid metabolism.
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-331-C00307) to J.C., and by the NIH/NIAAA R01AA12628 and U.S. Department of Agriculture, under agreement No. 1950-51000-056 to X-D.W.. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the U.S. Department of Agriculture.
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Smartshell Plus 12.9-Inch Ipad Pro Cases
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|By Marketwired .
Article Rating:
|February 6, 2013 08:00 AM EST
REDWOOD SHORES, CA -- (Marketwire) -- 02/06/13 -- Oracle (NASDAQ: ORCL)
News Facts
- To help customers achieve greater value from Oracle's PeopleSoft applications, Oracle today announced a new release of Oracle's PeopleSoft PeopleTools.
- PeopleSoft PeopleTools 8.53 continues Oracle's commitment to extend the value of PeopleSoft applications by providing new technology enhancements that deliver a dramatically improved user experience and help reduce ongoing operating costs.
- This latest release of PeopleSoft PeopleTools enables a new level of usability and productivity within the PeopleSoft applications by delivering a process rather than task-centric interaction model. PeopleSoft applications now incorporate high productivity features such as a cockpit style single stop WorkCenter for expert users and methods that improve all users' ability to simply, find and work with enterprise data in more visual ways.
- With this release, PeopleSoft customers will be better able to manage their total cost of ownership for PeopleSoft applications by leveraging options for system virtualization, instance consolidation and Oracle private cloud solutions.
- PeopleTools 8.53 is Oracle's latest effort to extend the value of PeopleSoft applications. This new release is designed to be a technology upgrade for all currently supported PeopleSoft applications and to power Oracle's next planned release of PeopleSoft.
- PeopleSoft PeopleTools is a comprehensive development toolset that is the technology foundation for PeopleSoft applications. PeopleTools enables application developers to build, configure and customize PeopleSoft applications quickly and easily.
PeopleTools 8.53 Improves Usability and Reduces Costs for Existing PeopleSoft Deployments
- The latest release of PeopleTools delivers a process-centric model for user interactions rather than a task-based approach with features such as PeopleSoft Activity Guides. This more intuitive user experience provides a visual layout for multiple step processes, across both PeopleSoft and non-PeopleSoft applications.
- The inclusion of Oracle's Secure Enterprise Search (SES) provides secure, free text search within PeopleSoft applications across multiple objects and multiple instances. With SES, PeopleSoft now enables users to take a more streamlined search-driven approach to navigating the system rather than hunting for actions in complex menus.
- Furthering the change in navigation, the expansion of the Related Actions Framework in PeopleTools 8.53 provides end users the ability to take contextually relevant action on objects in place of using traditional menu paths.
- The PeopleSoft user interface now showcases improved use and support of web-standard Cascading Style Sheets (CSS). Leveraging CSS more than ever, PeopleTools 8.53 enables users to easily configure their PeopleSoft system to reflect corporate design elements such as colors, graphics and web page behavior, delivering new look and feel options.
- In addition, the PeopleSoft Interaction Hub extends the native PeopleSoft application user interface to include Unified Application Navigation, role-based configurable homepages as well as a comprehensive suite of social and collaboration tools.
- Real-time, embedded decision support analysis capabilities are delivered in PeopleTools 8.53 by Pivot Grids. Pivot Grids are self-service, multi-dimensional analytics built into the applications that provide users with improved analytic capabilities and the business intelligence needed to make informed decisions.
- PeopleTools 8.53 also increases the productivity of professional users through the use of WorkCenters. WorkCenters consolidate user tasks, exceptions, alerts, links, reports, and queries into a single, secure, role based, cockpit style "command center" that can be personalized via end user configuration.
- Designed to significantly reduce the total cost of ownership, PeopleTools 8.53 enables Oracle private cloud deployments of PeopleSoft. Multiple PeopleSoft application instances can be consolidated on a single Oracle Exalogic Elastic Cloud machine, delivering improved application performance and scalability as well as improved system management, patching, and maintenance. Oracle VM Templates for PeopleSoft support rapid application provisioning and scaling, allowing customers to easily adopt the latest PeopleSoft application innovations.
Supporting Quote
- "Oracle's PeopleSoft PeopleTools 8.53 is designed to help customers derive greater value from their PeopleSoft investment," said Paco Aubrejuan, senior vice president and general manager, Oracle's PeopleSoft. "The functionality delivered in the latest version of PeopleTools should help users configure and customize their PeopleSoft applications in ways that provide a more intuitive user experience while also driving business value."
Supporting Resources
- Oracle's PeopleSoft Applications
- Oracle's PeopleSoft PeopleTools
- PeopleSoft Technology Blog
- PeopleSoft Apps Strategy Blog
- Oracle Human Capital Management Blog
- PeopleSoft Info on Twitter
- Oracle HCM on Twitter
About Oracle Applications
Over 65,000 customers worldwide rely on Oracle's complete, open and integrated enterprise applications to achieve superior results. Oracle provides a secure path for customers to benefit from the latest technology advances that improve the customer software experience and drive better business performance. Oracle Applications Unlimited is Oracle's commitment to customer choice through continuous investment and innovation in current applications offerings. Oracle's next-generation Fusion Applications build upon that commitment, and are designed to work with and evolve Oracle's Applications Unlimited offerings. Oracle's lifetime support policy helps ensure customers will continue to have a choice in upgrade paths, based on their enterprise needs. For more information on the latest Oracle Applications releases go to: www.oracle.com/applications.
About Oracle
Oracle engineers hardware and software to work together in the cloud and in your data center. For more information about Oracle (NASDAQ: ORCL), visit www.oracle.com.
Oracle and Java are registered trademarks of Oracle and/or its affiliates. Other names may be trademarks of their respective owners.
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With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...
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SYS-CON Events announced today that T-Mobile will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. As America's Un-carrier, T-Mobile US, Inc., is redefining the way consumers and businesses buy wireless services through leading product and service innovation. The Company's advanced nationwide 4G LTE network delivers outstanding wireless experiences to 67.4 million customers who are unwilling to compromise on ...
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SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in compute, storage and networking technologies, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/...
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NHK, Japan Broadcasting, will feature the upcoming @ThingsExpo Silicon Valley in a special 'Internet of Things' and smart technology documentary that will be filmed on the expo floor between November 3 to 5, 2015, in Santa Clara. NHK is the sole public TV network in Japan equivalent to the BBC in the UK and the largest in Asia with many award-winning science and technology programs. Japanese TV is producing a documentary about IoT and Smart technology and will be covering @ThingsExpo Silicon Val...
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The 20th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held June 6-8, 2017, at the Javits Center in New York City, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal ...
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The age of Digital Disruption is evolving into the next era – Digital Cohesion, an age in which applications securely self-assemble and deliver predictive services that continuously adapt to user behavior. Information from devices, sensors and applications around us will drive services seamlessly across mobile and fixed devices/infrastructure. This evolution is happening now in software defined services and secure networking. Four key drivers – Performance, Economics, Interoperability and Trust ...
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With billions of sensors deployed worldwide, the amount of machine-generated data will soon exceed what our networks can handle. But consumers and businesses will expect seamless experiences and real-time responsiveness. What does this mean for IoT devices and the infrastructure that supports them? More of the data will need to be handled at - or closer to - the devices themselves.
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World Bulletin/News Desk
An outbreak of Ebola has killed one person and is believed to have infected three others over the last week in northeastern Congo, medical charity Medecins Sans Frontieres said on Friday.
The outbreak is in Isiro, a busy town in Democratic Republic of Congo's Oriental province, which shares a border with Uganda, but the strain of the deadly disease is different to the one that killed 16 there last month, MSF said.
Ebola is transmitted to humans from monkeys and birds and causes massive bleeding in victims, with mortality rates as high as 90 percent.
Anja de Weggheleire, the medical coordinator for MSF in the area, said blood samples from one victim had confirmed Ebola in Isiro and there were at least three other suspected cases being treated in an MSF-supported local hospital.
"We cannot speak of a direct link between the two epidemics, I think unfortunately it's just pure coincidence," de Weggheleire told Reuters.
MSF was helping track and isolate people who may have come in contact with the disease, she added.
Authorities in Uganda said this week that the outbreak there was under control after they imposed strict measures to prevent Ebola from spreading in the west of the country.
However, Congo's health system is permanently stretched and MSF warned that preventing the spread of the disease from the town, a provincial transit point, could be a challenge.
"(The situation) is quite serious already ... Isiro is quite a busy place, quite well connected, that could make it quite complex to contain (the fever)," de Weggheleire added.
On Saturday, the White House said Trump had invited Duterte in a "friendly" call in which the leaders discussed the Filipino president's fight against drugs and the two countries' alliance.
The pope's call for a "negotiated solution" came in response to waves of protests by Venezuelans demanding new elections to pull the country out of a downward spiral.
At least 11,000 people flee from clashes in Democratic Republic of Congo to Angola in past few weeks
Both were "dangerous terrorist elements", and one, probably a foreigner, was a leader in a group linked to AQIM
Nationalist demonstrators forced their way into the building on Thursday evening and the ensuing riots left scores injured, including Social Democrat (SDSM) leader Zoran Zaev and other MPs.
Given the "challenging" security situation, the 28-nation alliance was weighing an increase of the personnel of its "Resolute Support" train, assist and advise mission from about 13,000 now, he told the Welt am Sonntag newspaper.
Le Pen has made a series of targeted campaign stops in a bid to close a 19-point gap in voter surveys with centrist frontrunner Emmanuel Macron, 39.
Renzi, 42, resigned as prime minister in December after Italians overwhelmingly rejected a constitutional referendum.
German prosecutors said Friday police had arrested a Swiss man they identified only as Daniel M., 54, who was suspected of espionage activities since early 2012.
The hope is that Brexit will solve a decades-old sovereignty dispute over the waterway between British-ruled Northern Ireland and the Republic of Ireland.
US president telephones President Rodrigo Duterte and discusses visit and other challenges facing Philippine leader
Another five Iraqis trying to flee western Mosul were executed by ISIL militants
Here are the main points in the worst natural disaster in Canadian history:
Oil is Libya's main natural resource, with reserves estimated at 48 billion barrels, the largest in Africa.
Heavy rains that hit Zimbabwe and killed 246 people have left only refugee camp in the country in a dire state
If North Korea carries out a nuclear test "I would not be happy," Trump told the CBS television network's "Face the Nation" program.


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Galvanized Bucket Sink with industrial pipe faucet
industrial design. by johnnie
Rustic industrial kitchen, panelled, marble work surface, metro tiles, exposed brick, filament bulbs, tongue and groove, scissor lights, AGA, white AGa, herb trough, wood effect tiles, ercol, ceiling beams, copper tap, movable island. Photographed by Malcolm Menzies ww.82mm.com Kitchen by http://blakeslondon.com
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Home and Delicious: design: höst restaurant in copenhagen Reclaimed wood bar and ceiling.
HIKKI Restaurant Bar in Osaka - Alexander Yukhimets
Easy access to outdoors...
HIKKI Restaurant Bar in Osaka - Alexander Yukhimets
Vertical Garden and Plant Selection
Love the patio at Cucina Enoteca in Irvine, would love the our future patio to look like this.


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Filter Results:
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- Alexander V Kulikov, Maria A Tikhonova, Victor A Kulikov
- Journal of neuroscience methods
- 2008
New modification of the open field was designed to improve automation of the test. The main innovations were: (1) transmitted lighting and (2) estimation of probability to find pixels associated with an animal in the selected region of arena as an objective index of spatial preference. Transmitted (inverted) lighting significantly ameliorated the contrast… (More)
- A V Kulikov, D V Bazovkina, E M Kondaurova, N K Popova
- Genes, brain, and behavior
- 2008
Catalepsy or pronounced freezing is a natural passive defense strategy in animals and a syndrome of some mental disorders in human. Hereditary catalepsy was shown to be associated with depressive-like features in rats and mice. The loci underlying the difference in predisposition to catalepsy between catalepsy-prone CBA/lacJ and catalepsy-resistant AKR/J… (More)
- V S Naumenko, D V Bazovkina, E M Kondaurova, E A Zubkov, A V Kulikov
- Genes, brain, and behavior
- 2010
In the present study, the 5-HT(2A) and 5-HT(1A) receptors functional activity and 5-HT(2A) receptor gene expression were examined in the brain of ASC/Icg and congenic AKR.CBAD13Mit76C mouse strains (genetically predisposed to catalepsy) in comparison with the parental catalepsy-resistant AKR/J and catalepsy-prone CBA/Lac mouse strains. The significantly… (More)
- Vladimir S Naumenko, Rimma V Kozhemyakina, Irina F Plyusnina, Alexander V Kulikov, Nina K Popova
- Behavioural brain research
- 2013
Antisocial aggressive behavior in adolescents represents growing clinical and social problem. Previously the implication of 5-HT1A receptor in the regulation of fear-induced aggression was shown. Here, the involvement of 5-HT1A receptor in infancy-onset genetically defined aggression was studied on Norway rats selectively bred for high level or for the lack… (More)
- V S Naumenko, A V Kulikov, +8 authors N K Popova
- Neuroscience
- 2015
Mice of C57BL/6J strain were exposed to 1-month spaceflight on Russian biosatellite Bion-M1 to determine the effect of long-term actual spaceflight on the expression of genes involved in the processes of neurogenesis and apoptosis. Specifically, we focused on the genes encoding proapoptotic factor BAX, antiapoptotic factor BCL-XL, brain-derived neurotrophic… (More)
- I P Voronova, A V Kulikov, N K Popova, T V Kozyreva
- Rossiiskii fiziologicheskii zhurnal imeni I.M…
- 2006
The mRNA expression of serotonin receptors 5-HT1A and 5-HT2A was investigated by the quantitative method RT-PCR in rats adapted to cold (5 weeks at +4 -(+6) degrees C) and in control (5 weeks at +20-22 degrees C). Four brain regions were examined: frontal cortex, hypothalamus, hippocampus, and midbrain. The influence of cold adaptation on the mRNA… (More)
- Nina K Popova, Vladimir S Naumenko, Irena Z Plyusnina, Alexander V Kulikov
- Journal of neuroscience research
- 2005
The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-induced hypothermia and lower lip… (More)
- Nina V Volf, Alexander V Kulikov, Cyril U Bortsov, Nina K Popova
- Neuroscience letters
- 2009
The purpose of this study was to examine the potential association between the S (short) and L (long) alleles of the 5-HTTLPR polymorphism of the serotonin transporter (5-HTT) gene and verbal and figural creative ability. Sixty-two unrelated Caucasian university students (29 men and 33 women) participated in the experiment. The results showed a significant… (More)
- Alexander V Kulikov, Vladimir S Naumenko, Irina P Voronova, Maria A Tikhonova, Nina K Popova
- Journal of neuroscience methods
- 2005
Brain serotonin 5-HT(1A) and 5-HT(2A) receptors have been implicated in both normal and pathological behavior, and in the action of anxiolytic and antidepressant drugs. In this study, detailed description and verification of a new RT-PCR technique to quantify the number of copies of 5-HT(1A) and 5-HT(2A) receptor mRNAs in the brain is presented. The number… (More)
- E M Kondaurova, D V Bazovkina, A V Kulikov, N K Popova
- Genes, brain, and behavior
- 2006
Catalepsy (pronounced motor inhibition) is a natural defensive reaction against predator. Recently, the quantitative trait locus for catalepsy was mapped on mouse chromosome 13 near the 5-HT(1A) serotonin receptor gene. Here, the linkage between catalepsy and the 5-HT(1A) receptor gene was verified using breeding experiment. Selective breeding for high… (More)


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Update on the Israeli-Palestinian Peace Process
CFR Senior Fellow Elliott Abrams leads a conversation on U.S. policy toward the Israeli-Palestinian peace process, as part of CFR's Religion...
Interviewees: Elliott Abrams, Senior Fellow for Middle Eastern Studies, Council on Foreign Relations
Steven A. Cook, CFR Hasib J. Sabbagh Senior Fellow for Middle Eastern Studies, Council on Foreign Relations
Interviewer: Bernard Gwertzman, Consulting Editor, CFR.org
May 26, 2010
Abrams, who formerly served in the Bush administration as a Middle East specialist in the National Security Council, said he thought the proximity talks would lead to direct talks, "but I don't think that when they sit at the same table, they're going to achieve a final status agreement." Cook said, "If it's at all possible, I'm perhaps more skeptical than Elliott on this issue."
Both, however, held out the possibility that the talks could lead to creating the framework for a Palestinian state on the West Bank. Abrams said, "The negotiations should, in a sense, be seen as a façade, behind which the institutions of a Palestinian state can, one hopes, be created in reality on the ground in the West Bank." Cook agreed: "I think that it is entirely possible, and this is something that the Palestinians have actually been talking about for quite some time."
Terms of Use: I understand that I may access this audio and/or video file solely for my personal use. Any other use of the file and its content, including display, distribution, reproduction, or alteration in any form for any purpose, whether commercial, noncommercial, educational, or promotional, is expressly prohibited without the written permission of the copyright owner, the Council on Foreign Relations. For more information, write firstname.lastname@example.com.
The definitive account of the secret war in Laos, which forever changed the CIA from a relatively small spying agency into an organization with vast paramilitary powers. More
CFR President Haass argues for an updated global operating system to address challenges from terrorism to climate change. More
Alden provides an enlightening history of the last four decades of U.S. trade policies and a blueprint for how to keep the United States competitive in a globalized economy. More
The Task Force finds that Alaska and the Arctic are of growing economic and geostrategic importance and recommends actions to improve the United States' strategic presence in the Arctic region.
The Task Force recommends revising U.S. policy toward North Korea to break the cycle of North Korean provocation and promote stability in Northeast Asia.
India now matters to U.S. interests in virtually every dimension. This Independent Task Force report assesses the current situation in India and the U.S.-India relationship, and suggests a new model for partnership with a rising India.
Rates of heart disease, cancer, diabetes, and other noncommunicable diseases (NCDs) in low- and middle-income countries are increasing faster than in wealthier countries. The report outlines a plan for collective action on this growing epidemic.
CFR Senior Fellow Elliott Abrams leads a conversation on U.S. policy toward the Israeli-Palestinian peace process, as part of CFR's Religion...
Listen to CFR's Steven A. Cook discuss the Israel-Palestinian conflict in light of the release of the Goldstone Report, which was recently...
Listen to Steven A. Cook, CFR's Douglas Dillon Fellow, discuss the status of the Israel/Palestine peace process sixty years after the...
CFR Senior Fellow Elliott Abrams leads a conversation on U.S. policy toward the Israeli-Palestinian peace process, as part of CFR's Religion...


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Single Minded is a perk that can be upgraded 3 times on the EGO Grid.
You reload faster while standing still.
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