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The new rebrand reflects the Channel's public service remit focussed on innovation, diversity, and taking creative risks. We took the essence of the iconic Channel 4 logo and found hundreds…+ More details
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why do birds is the new global lead agency for Hyundai sound branding. Following a pitch, why do birds developed a holistic sound concept that extends across all Hyundai media and sound applications. __ why…+ More details
So this is how its done! The A -Z of creating a project with yours truly and my talented band of magicians. I wanted to show all the different steps involved in the creation process while…+ More details
Making of A Monster Calls (Animation Sequence)08:07
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سكس بنات واولاد سكس وهي نايمه ومستلذه A television series that is intended to be broadcast a finite number of episodes is usually called a miniseries or serial although the latter term also has other meanings.
سكس بنات واولاد This confuses Inoue and she asks how he knows her name. A television program USA, television programme UK, or television show USA/UK is something that people watch on television. Across the room, Inoue is curled up, shivering in fear unable to discern what is happening to them. Examples of episodes include the founding of Wilmington, Delaware in Charles Reades The Disinherited Heir and the individual events comprising the picaresque novels and medieval romances.
Many serialistic shows begin with a Previously on. Today, advertisements play a role in most television programming, such that each hour of programming can contain up to 15 minutes of advertisements in some countries. سكس بنات واولاد Often, an animatic or story reel is made after the soundtrack is created, but before full animation begins.
Some feature biseinen beautiful man, males of more masculine appearance than bishonen. Ecchi means sex and regular pervert. سكس لام Inoues attention is drawn to the blood dripping from her hand. سكس بنات مع شباب Advertising agencies today employ the use of animatics to test their commercials before they are also made into full up spots.


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Ohiolink Book Depository Program
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Located within Ohio this is a statewide system of five book repositories. These are: Northeastern Ohio Cooperative Regional Library Depository, Northwest Ohio Regional Book Depository, Ohio State U Library Book Depository, Southeast Ohio Regional Library Depository, and Southwest Ohio Regional Library Depository (SWORD)
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- Archive Type: Print
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Soret and thermosolutal effects on natural convection in a vertical cavity filled with a binary mixture
Version of Record online: 30 JUN 2010
DOI: 10.1002/cjce.20350
Copyright © 2010 Canadian Society for Chemical Engineering
The Canadian Journal of Chemical Engineering
Volume 88, Issue 5, pages 718–727, October 2010
Additional Information
How to Cite
Alloui, Z., Merabtine, A. and Vasseur, P. (2010), Soret and thermosolutal effects on natural convection in a vertical cavity filled with a binary mixture. Can. J. Chem. Eng., 88: 718–727. doi: 10.1002/cjce.20350
Publication History
- Issue online: 30 JUN 2010
- Version of Record online: 30 JUN 2010
- Manuscript Revised: 30 NOV 2009
- Manuscript Accepted: 30 NOV 2009
- Manuscript Received: 29 SEP 2009
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Novartis Tests New Alzheimer's Drug on People Who Don't Have the Disease
In part four of our series, we look at how market conditions affect variable annuities. VAs may appear, on paper, to be a win-win, but the reality is more nuanced.
The insurer's variable annuities dipped 39% year-over-year in the second quarter, offering a glimpse into the power of big distributors like Fidelity.
Intertrust Acquires Assets of Kiora Media to Bring Trusted Content Delivery to Offline Audiences
Fixed indexed annuity sales are steadily gaining on those of variable annuities, thanks in large part to continued low interest rates.
Smart-beta strategies got their latest seal of approval in the form of a $100 million mandate from variable annuity giant Jackson National, which has added the DoubleLine Shiller Enhanced CAPE Fund to its menu of VA investment options.
ETFs could help solve the high costs that dog variable annuities.
Tight restrictions are placed on investment options in VAs with guaranteed income to reduce their risk. Returns have lagged as a result, frustrating advisers and investors.
Following record MetLife fine, regulator says VAs are now at the core of their focus: complex products marketed to seniors.
Glenn Daily, insurance expert and variable annuity dissenter, says the complexity of these products' guaranteed benefits is beyond most advisors' ability to assess.
©2017 Morningstar Advisor. All right reserved.


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Archive for Game Wrap-ups
A brief look into last night's winPosted by: | Comments
The Rangers beat the Kings 3-0 last night, in a game that I did not watch. West coast games are rough. So I asked people who did watch, and basically came up with one overall summary. The Rangers started slow, but looked good in the first. Antti Raanta bailed them out in the second. Then they sat back on a lead in the third. Basically par for the course for the Rangers.
I'm not going to analyze a game that I didn't watch. It's unfair to me and to you. So instead I'm taking a different approach. I'm going to use last night's individual game score to try to predict who is coming out of the lineup for Kevin Klein tonight.
Rangers can't complete sweep as Schneider steals one in JerseyPosted by: | Comments
Cory Schneider made 38 saves, many brilliant, as the Devils topped the Rangers 3-2 in overtime. Schneider was the story of the game, as the Rangers peppered him with quality shot after quality shot. But Schneider was the difference maker here. Antti Raanta was great as well, but he came up one save short.
The Rangers controlled the game from the get-go, using superior speed and skill to overwhelm a thin Devils squad. This was also a chippy game. With an all-out brawl highlighting the second period. It's been a while since we've seen a passion-fueled brawl over the staged fights we are used to. Give me passion over staged fights any day.
As for the game, it's not that important. The Rangers didn't clinch yet. They will though.
On to the goals:
MSG woes continue as Rangers fall to BoltsPosted by: | Comments
The Rangers dropped a tightly contested 3-2 result to the Tampa Bay Lightning on Monday, unable to complete the sweep of their three game season series with the Bolts. While the result on its own isn't disastrous, the main concern for the Blueshirts is their continued mediocre play at Madison Square Garden, as well as a lack of ability to sustain a full, 60-minute effort.
In some ways, the Rangers lost this game in the first period. While they were utterly dominant, generating 23 total shot attempts and 11 scoring chances, they went to the locker room tied 1-1. As the game wore on, the Lightning tightened up defensively and were able to capitalize on their chances, while the Rangers let their few golden opportunities go begging.
Rangers end road trip on a highPosted by: | Comments
The Rangers took care of business on Sunday night, defeating the out-of-contention Red Wings 4-1 in the teams' last-ever meeting at historic Joe Louis Arena. This was a solid all-around performance for the Blueshirts as they bounced back from Thursday night's loss in Carolina.
This game was the Ryan McDonagh show. The Rangers captain was all over the ice, making solid defensive plays, initiating the offense, and joining the rush. McDonagh was rewarded with two goals on the night as well as First Star honors, and continues to carry a defense corps that is otherwise average at best.
Three powerplay goals not enough as Rangers fall to CarolinaPosted by: | Comments
The Rangers powerplay awoke with force last night, scoring three goals with the man advantage. However it was not enough, as a pair of two-goal bursts by the Canes doomed the Rangers as they lost by a score of 4-3. The first burst of two quick goals by Carolina was the result of just terrible defense. There's really no way around it. But the third Carolina goal is the one that Rangers fans will be upset about, as it was clear goaltender interference. The explanation was terrible and the consistency on these calls is terrible.
While that third goal hurts, the Rangers lost the game in the first with those two lapses on defense. A team like Carolina that struggles to score should not be able to score that easily. Alas, the Rangers allowed them to get an early lead and did not put them away when they had the chance. Perhaps things are different when half the roster isn't injured.
On to the goals:
Tanner Glass the Cat's Meow as Rangers top PanthersPosted by: | Comments
Although they got off to a slow start, the Rangers eventually took control of the pace of their Tuesday night matchup against the Florida Panthers following a timely goal by none other than Tanner Glass. It helped the Rangers gain some momentum that would largely remain on their side of the ice until the Panthers began a serious pushback following their first goal of the game. Still, outstanding goaltending yet again was the difference, with Hank keeping the Rangers in it at times and helping the team ultimately seal the deal.
Chris Kreider doing what he does best, deflecting goals in from in front of the net. After a failed attempt by Florida at clearing the zone, Mats Zuccarello works the puck up along the right boards to Steve Kampfer at the point. He lets a low one fly towards the net, which Kreider tips in to get the Rangers on the board.
Raanta steals the show, Zibanejad wins it in overtimePosted by: | Comments
In a game where the Rangers needed to rebound and send a message to themselves, they once again relied on their goaltender to bail them out. Antti Raanta was brilliant in this game, making 38 saves, many of them spectacular. The Rangers were flat after the first period, getting crushed by the Lightning over the last 40 minutes of the game. It was Raanta that kept the game scoreless.
As expected, the additions of Steven Kampfer and Tanner Glass didn't move the needle much. The Rangers certainly had a good start to the game, realizing an urge to play better. Glass had his fight, trying to motivate his teammates. Kampfer got hit from behind and almost decapitated, and then the first ended. After that, the Rangers were chasing the Bolts all around the ice, taking many penalties in the process. That said, Glass was a part of one of my favorite all time gifs, which came in this game.
Then the overtime happened, and I have to admit I love overtime. It was Mika Zibanejad who said enough was enough, finally getting off the schneid.
On to the goals:
In a word: BadPosted by: | Comments
So I did not get a chance to catch most of the game last night, only coming home with 13 minutes left in the third period. In fact, I turned on the tv just as Jordie Benn made it 4-1. What can I say? I have great timing. This also seems like a game I should be happy that I missed. But I posed a question on Twitter, hoping you could all fill me in, and suffice it to say you didn't let me down.
Not watching tonight. So how do they look?
— Dave Shapiro (@BlueSeatBlogs) March 5, 2017
So let's look at some of the best responses.
Rangers best Bruins on Lundqvist's B-DayPosted by: | Comments
It was a happy birthday for Henrik Lundqvist in Boston on Thursday night, with the Rangers coming out on top 2-1 over the Bruins. Although they were grossly outshot in the first period and struggled to do pretty much anything productive (exit the zone, enter the zone, get shots off, etc), they came back in the second and third, ultimately taking the lead on a great goal by Pavel Buchnevich in the third period.
Lindberg extended that lead with a beauty goal himself, and although Hank gave up a weird one to Brad Marchand his play on the whole was spectacular. Certainly there were some problem areas (the man-advantage was not exactly advantageous, for example) but not a whole lot to complain about from this blogger – it was a choppy, weird game for both teams and the Rangers ultimately came out on top.
Rangers no match for Columbus at the GardenPosted by: | Comments
Perhaps it was fatigue. Perhaps not, since Columbus was also on the second of a back to back. But the Rangers were no match for the Columbus Blue Jackets last night at MSG. The Blue Jackets shelled the Rangers offensively and physically often. They then took advantage of defensive breakdowns and penalties to build a solid lead. The Rangers kept it close early, but the Blue Jackets were able to break it open with three straight.
Sergei Bobrovsky wasn't tested much this game, giving up one goal to Rick Nash on a good passing play. Aside from that, most of the shots were in clear sight. Henrik Lundqvist didn't really stand a chance on four of the goals against, but an argument can be made about one of them (Wennberg's second), where Hank came out of the crease to try to prevent a breakaway.
On to the goals:


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This meta-analysis was performed to evaluate the role of toll-like receptor 4 (TLR-4) in colorectal carcinogenesis.
The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched from inception through November 1st, 2013 without language restrictions. Odds ratios (ORs) or standardized mean differences (SMD) with their 95% confidence intervals (CI) were calculated.
Fourteen case-control studies met the inclusion criteria for this meta-analysis. A total of 1,209 colorectal cancer (CRC) cases and 1,218 healthy controls were involved in this meta-analysis. Two common polymorphisms (299 A>G and 399 C>T) in the TLR-4 gene, TLR-4 mRNA and protein expression were assessed. Our meta-analysis results revealed that the TLR-4 399 C>T polymorphism might increase the risk of CRC (allele model: OR = 1.77, 95%CI = 1.32∼2.36, P<0.001; dominant model: OR = 1.83, 95%CI = 1.32∼2.52, P<0.001; respectively). However, we found no correlation between the TLR-4 299 A>G polymorphism and CRC risk (all P>0.05). A subgroup analysis by ethnicity suggested that TLR-4 genetic polymorphisms were associated with an increased risk of CRC among Asians (allele model: OR = 1.50, 95%CI = 1.19∼1.88, P = 0.001; dominant model: OR = 1.49, 95%CI = 1.16∼1.92, P = 0.002; respectively), but not among Caucasians and Africans (all P>0.05). Furthermore, our results showed that TLR-4 mRNA and protein levels in CRC patients were higher than those in healthy controls (TLR-4 mRNA: SMD = 2.51, 95%CI = 0.98∼4.05, P = 0.001; TLR-4 protein: OR = 4.75, 95%CI = 1.16∼19.36, P = 0.030; respectively).
Citation: Li X-X, Sun G-P, Meng J, Li X, Tang Y-X, Li Z, et al. (2014) Role of Toll-Like Receptor 4 in Colorectal Carcinogenesis: A Meta-Analysis. PLoS ONE 9(4): e93904. https://doi.org/10.1371/journal.pone.0093904
Editor: Masaru Katoh, National Cancer Center, Japan
Received: December 6, 2013; Accepted: March 9, 2014; Published: April 4, 2014
Copyright: © 2014 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the Foundation of Education Department of Liaoning Province (No. 2008781) and the Natural Science Foundation of Liaoning Province (Nos. 201102281 and 20062053). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Colorectal cancer (CRC), which includes colon and rectal cancers, is the third most commonly diagnosed cancer in males and the second in females [1], [2]. The symptoms of CRC typically include rectal bleeding and anemia, which are sometimes associated with weight loss and changes in bowel habits [3]. It has been recognized that colorectal cancer is a multifactorial disease caused by complex interactions between environmental and genetic factors [4]. Risk factors for CRC consist of high intakes of fat and alcohol, obesity, smoking and lack of physical exercise [5]. Nowadays, many candidate genes have been identified, such as toll-like receptor 4 (TLR-4), which may be implicated in the genesis of colorectal cancer [6], [7].
TLR-4 belongs to a family of Toll-like receptors (TLRs), which are receptors playing the main role in the recognition of a wide array of pathogens, including viruses, bacteria, protozoa, and fungi [8]. The human TLR-4 gene is located in chromosomal region 9 (9q32-q33) and consists of four exons and three introns with an overall length of approximately 19 kb [9]. As one of the most actively investigated TLR, TLR-4 has been implicated in signal transduction events induced by the lipopolysaccharide of gram-negative bacteria and its activation in the production of several pro-inflammatory, antiviral and anti-bacterial cytokines [10], [11]. Since TLR-4 is critical in immune and inflammation responses to various bacteria in the intestine [12], single nucleotide polymorphisms (SNPs) in TLR-4 may decrease the response to bacterial components, impact gut homeostasis, result in the impairment of TLRs activation, and thereby be conducive to the development of several inflammatory diseases including CRC [13], [14]. Furthermore, human CRC cell lines with high rates of microsatellite instability were found to stimulate the activation of TLR-4 through the release of cytokines, and elevate the level of TLR-4 mRNA, thereby inducing the pathogenesis of CRC [15]. Therefore, it was hypothesized that TLR-4 might play important roles in the development and progression of CRC [16]. Additionally, it is also worth noting that numerous studies have been conducted to investigate the potential associations between common polymorphisms in the TLR-4 gene and CRC risk, especially focusing on two SNPs, (299 A>G, rs4986790 and 399 C>T, rs4986791), which are located in the extracellular domain of TLR-4 [8], [10], [17]. These two important SNPs may alter the amino acid sequence of the TLR-4 protein, disrupting the normal structure of the extracellular domain of the TLR-4 and TLR-4 signaling [14]. The dysregulation of TLR-4 signaling may change the ligand binding and balance between pro- and anti-inflammatory cytokines, creating a pro-inflammatory environment that favors tumor growth, thereby modulating the risk of CRC [10]. However, previous studies have arrived at contradictory results [10], [13], [18]. Consequently, we performed the present meta-analysis to evaluate the exact role of TLR-4 in colorectal carcinogenesis.
Literature search
The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. The following keywords and MeSH terms were used: ["colorectal cancer" or "CRC" or "colorectal tumor" or "colorectal neoplasm" or "colorectal carcinogenesis" or "colon cancer" or "rectal cancer"] and ["toll-like receptor 4" or "TLR-4" or "toll-4 receptor" or "toll 4 receptor"]. We also performed a manual search to find other potential articles.
Selection criteria
The included studies had to meet all the following criteria: (1) the study must be clinical cohort or case-control study; (2) the study must relate to the role of TLR-4 in colorectal carcinogenesis; (3) all patients must conform to the diagnostic criteria of CRC; (4) the study must provide sufficient information about TLR-4 SNP frequencies, mRNA or protein expressions. If the study did not meet the inclusion criteria, it was excluded. When authors published several studies using the same subjects either the most recent or the largest sample size publication was included. The supporting PRISMA checklist is available as supplementary information; see Checklist S1.
Data extraction
Relevant data were systematically extracted from all included studies by two researchers using a standardized form. The researchers collected the following data: language of publication, publication year, the first author's surname, geographical location, design of study, sample size, the source of the subjects, SNP frequencies, mRNA/protein levels, source of samples, genotyping method, mRNA/protein detection method, etc.
Quality assessment
Methodological quality was independently assessed by two researchers according to the Newcastle-Ottawa Scale (NOS) criteria [19]. The NOS criteria assigns scores based on three aspects: (1) subject selection: 0∼4; (2) comparability of subject: 0∼2; (3) clinical outcome: 0∼3. Total NOS scores range from 0 to 9 with a score ≥7 indicating high quality. The supporting NOS score criterion is available in Supplement S1.
Statistical analysis
The STATA version 12.0 (Stata Corp, College Station, TX, USA) software was used for this meta-analysis. We calculated crude odds ratio (OR) with their 95% confidence interval (95%CI) to evaluate the specified relationships. The Z test was used to estimate the statistical significance of pooled statistics. The Cochran's Q-statistic and I2 test were used to evaluate potential heterogeneity between studies [20]. If Q-test showed a P<0.05 or I2 test exhibited >50%, indicating significant heterogeneity, the random-effect model was conducted; otherwise the fixed-effects model was used. We also performed subgroup and meta-regression analyses to investigate potential sources of heterogeneity. In order to evaluate the influence of single studies on overall estimates, a sensitivity analysis was performed. We also conducted Begger's funnel plots and Egger's linear regression test to investigate publication bias [21].
Characteristics of included studies
Initially, the searched keywords identified 291 articles. We reviewed the titles and abstracts of all articles and excluded 156 articles; full texts and data integrity were then reviewed and a further 121 articles were excluded. Finally, 14 case-control studies were included in this meta-analysis [10], [13], [14], [18], [22]–[31]. Publication years of the eligible studies range from 2006 to 2013. Figure 1 shows the selection process of eligible articles. The distribution of the number of topic-related literature in electronic databases over the last decade is shown in Figure 2. A total of 2,427 subjects were involved in this meta-analysis, including 1,209 CRC patients and 1,218 healthy controls. Eleven studies were performed in Asian populations, two studies in Caucasian populations and only one study in an African population. The NOS scores of all included studies were ≥5 (moderate-high quality). We summarized the study characteristics and methodological quality in Table 1.
Fourteen case-control studies were included in this meta-analysis.
TLR-4 genetic polymorphisms with CRC risk
There were six studies focused on the correlation of TLR-4 genetic polymorphisms with susceptibility to CRC. Our meta-analysis findings on the relationships between TLR-4 genetic polymorphisms and the risk of CRC are shown in Table 2. The random effects model was conducted due to the existence of significant heterogeneity between studies. Two common polymorphisms in the TLR-4 gene (299 A>G, rs4986790; 399 C>T, rs4986791) were assessed. Our meta-analysis results revealed that the TLR-4 399 C>T polymorphism might increase the risk of CRC (allele model: OR = 1.77, 95%CI: 1.32∼2.36, P<0.001; dominant model: OR = 1.83, 95%CI: 1.32∼2.52, P<0.001; respectively) (Figure 3). Nevertheless, there was no evidence to support any association between the TLR-4 299 A>G polymorphism and CRC risk (all P>0.05).
(a) TLR-4 299 A>G; (b) TLR-4 399 C>T.
Subgroup analyses were conducted based on ethnicity, genotyping method and sample size to investigate potential sources of heterogeneity. Our findings suggested that genetic polymorphisms in TLR-4 genes were associated with an increased risk of CRC among Asian populations (allele model: OR = 1.50, 95%CI = 1.19∼1.88, P = 0.001; dominant model: OR = 1.49, 95%CI = 1.16∼1.92, P = 0.002; respectively), but not among Caucasian or African populations (all P>0.05) (Figure 4). We also found that TLR-4 genetic polymorphisms were closely linked to CRC risk in the PCR-RFLP subgroup (allele model: OR = 1.44, 95%CI = 1.16∼1.78, P = 0.001; dominant model: OR = 1.44, 95%CI = 1.14∼1.82, P = 0.002; respectively) and the large sample-size subgroup (allele model: OR = 1.48, 95%CI = 1.19∼1.86, P = 0.001; dominant model: OR = 1.43, 95%CI = 1.10∼1.87, P = 0.008; respectively), but no similar correlations were observed in non-PCR-RFLP or small sample-size subgroups (all P>0.05). Our meta-regression analyses suggested that ethnicity was a major source of heterogeneity (as shown in Table 3).
(a) TLR-4 299 A>G; (b) TLR-4 399 C>T.
Expression of TLR-4 mRNA and protein in colorectal carcinogenesis
Five studies evaluated the potential role of TLR-4 mRNA expression in colorectal carcinogenesis. The pooled results of these studies indicated that CRC patients had a higher levels of TLR-4 mRNA than those of healthy controls (SMD = 2.51, 95%CI = 0.98∼4.05, P = 0.001) (Figure 5). In addition, three studies reported correlations between TLR-4 protein expression and colorectal carcinogenesis. Meta-analysis results also showed a significant difference in TLR-4 protein levels between CRC patients and healthy controls (OR = 4.75, 95%CI = 1.16∼19.36, P = 0.030).
Sensitivity analysis and publication bias evaluation
The results of a sensitivity analysis suggested that no single study significantly influenced overall pooled estimates (Figure 6). We also found no evidence of obvious asymmetry in Begger's funnel plots (Figure 7). Egger's test also did not display strong statistical evidence of publication bias (allele mode: t = −1.12, P = 0.297; dominant model: t = −0.92, P = 0.386; TLR-4 mRNA: t = −2.29, P = 0.106; TLR-4 protein: t = 4.03, P = 0.155; respectively).
(a) TLR-4 299 A>G; (b) TLR-4 399 C>T.
TLR-4, a member of the IL-1R (IL-1 receptor) superfamily, shares the cytoplasmic region known as the TIR (Toll/IL-1R) domain [32]. TLRs have been suggested to play a key role in the recognition of pathogens, including protozoa, viruses, bacteria, and fungi, and thus are involved in innate and adaptive immune response processes [33], [34]. In general, TLR-4 is highly expressed in monocytes, macrophages, lymphocytes, and dendritic cells, and can also be observed in many types of epithelial and endothelial cells [35], [36]. It is widely accepted that epithelial cells of the intestine are responsible for regulating the immune response to bacterial antigen, while the sustained activation of the TLR-4 signaling pathway accompanied with an elevated levels of TLR-4 mRNA may stimulate the expression of TLR-4 and in turn act as a critical mechanism for the acquisition of malignant phenotypes by epithelial cancer cells [37]. Consequently, genetic polymorphisms in TLR-4 may promote the synthesis of proinflammatory cytokines, which are causative factors in the pathogenesis of CRC 38–40. Furthermore, the expression of TLR-4 mRNA and protein has also been postulated to be strongly associated with colorectal carcinogenesis [41].
In order to evaluate the exact role of TLR-4 in colorectal carcinogenesis, we performed a meta-analysis of 14 case-control studies with a total of 1,209 CRC patients and 1,218 healthy controls. Our meta-analysis results indicated that the TLR-4 399 C>T polymorphism was significantly associated with the risk of CRC, which suggests that this polymorphism may be involved in the development of CRC. However, we found no evidence of any associations between the TLR-4 299 A>G polymorphism and CRC risk, revealing that this polymorphism may not be an important determinant of colorectal carcinogenesis. Although the exact function of TLR-4 genetic polymorphisms in colorectal carcinogenesis is still not well understood, on possible explanation is that mutations in the TLR-4 gene could decrease cyclooxygenase-2 (COX-2) expression, which is responsible for increasing commensal bacteria, thereby causing inflammation and leading to CRC [42]. In addition, it is well established that SNPs may contribute to amino acid substitutions altering protein function and may also change transcription factor binding motifs, promoting an alternative translation initiation codon, and thereby resulting in a wild-type transcript down-regulation in the promoter region [43], [44]. In fact, 1196C/T and 896A/G are the most studied genetic variations of TLR-4. The nonsynonymous polymorphisms TLR-4 1196C/T (major allele C, minor allele T, rs4986791) and TLR-4 896A/G (major allele A, minor allele G, rs4986790), which are located in the fourth exon, may affect the extracellular domain of TLR4 and lead to the transitions of cytosine-thymine (C-T) and adenine-guanine (A–G), respectively [8]. In turn, such progressions may cause substitutions in amino acids: isoleucine instead of threonine at 399 position (Thr399Ile) and glycine instead of aspartic acid at 299 position (Asp299Gly) [45]. In this regard, TLR-4 SNPs of the transmembrane domain may lead to defects in intracellular receptor transfer that prevent the receptor to be converted to the cell surface where it works, and thereby may correlate with disorders in the immune system related to cancer of the intestinal mucosa [41]. A subgroup analysis indicates that TLR-4 genetic polymorphisms were associated with an increased risk of CRC among Asians, but not among Caucasians or Africans, which suggests that ethnicity might have been a source of heterogeneity. While the molecular basis of ethnic differences in susceptibility to CRC is currently not fully understood, possible sources of such differences could be natural selection and random genetic drift. A meta-regression analysis also confirms that ethnicity might have been a major source of heterogeneity. In addition, we found that TLR-4 mRNA and protein levels in CRC patients were higher than those in healthy controls, revealing that TLR-4 mRNA and protein may be implicated in the development and progression of CRC. These results may be explained by the fact that TLR-4 is a crucial regulator that helps maintain the balance between commensal bacteria in the gut and the mucosal immune system, while the abnormal expression of TLR-4 leads to the breakdown of homeostasis, which may be a key feature in the pathogenesis of CRC [41]. Furthermore, TLR-4 activation may promote the development of CRC by including enhanced COX-2 expression and increased EGFR signaling [46]. All in all, our findings were consistent with previous studies that TLR-4 may play an important role in colorectal carcinogenesis and may be a potential biomarker for the early diagnosis of CRC.
As the first meta-analysis focusing on the role of TLR-4 in colorectal carcinogenesis, our study has some limitations. First, our results lacked sufficient statistical power to assess the exact roles of TLR-4 SNPs, mRNA and protein expression in colorectal carcinogenesis due to relatively small sample sizes. Second, meta-analysis is a retrospective study that may lead to subject selection bias, which thus may have affected the reliability of our results. Third, our meta-analysis failed to obtain original data from included studies, which may have limited a further evaluation of the potential role of TLR-4 in the development and progression of CRC. A fourth limitation of this article is the fact that the significant P-values reported were driven by one single study with a small sample size, which may seriously affect the accuracy and comprehensiveness of this result. In addition, the inclusion criteria of cases and controls were not well defined in all included studies, which might also influence our results. Most importantly, this study was based on a small number of studies with very small sample sizes, especially for epidemiological research, which constrains the general applicability of our findings.
In conclusion, our findings provide empirical evidence that TLR-4 may play an important role in colorectal carcinogenesis. Thus, TLR-4 is a promising potential biomarker for the early diagnosis of CRC. However, due to the limitations mentioned above, more research studies with larger sample size are needed to achieve a more precise statistical analysis.
Supporting Information
Checklist S1.
PRISMA Checklist.
Supplement S1.
The Newcastle-Ottawa Scale for assessing methodological quality.
Flow Diagram S1.
Flow chart of literature search and study selection. Fourteen case-control studies were included in this meta-analysis.
We would like to acknowledge the reviewers for their helpful comments on this paper.
Author Contributions
Conceived and designed the experiments: X-XL. Performed the experiments: X-XL G-PS JM XL. Analyzed the data: X-XL Y-XT ZL. Contributed reagents/materials/analysis tools: X-XL M-FW G-FL X-BL. Wrote the paper: X-XL.
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Question about Samsung Cell Phones
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i need the default unlock code, the phone was locked be mistake
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
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My Education: Michael Crowe
Next up in our student flash backs is Michael Crowe, from the class of 2001 and Liverpool John Moores University where he studied creative writing. Now a days, Michael continues to find himself composing Mysterious Letters to everyone in the world with his art-partner (p-art-ner?) Lenka Clayton – they were resident in the Simultanhalle gallery in Cologne during August. Before and after these missives, he publishes his own excellent written works, and even more recently he contributed to a new zine by David Rule and Jamie Sutcliffe about Deputy Hawk from Twin Peaks.
The first image is 100 poems passed between work mates circa 2001: "I've lost most of these thank goodness." Also, a number of letters written whilst in Cologne this year.
What advice, based on your own experience, would you offer those still studying?
I'm terrible at giving (good) advice but think it's worth trying to really get into something outside of your course. You still put Herculean energy into your main subject, but with this other interest you might jut into your course from a weirder, more unique angle. So if you're doing fine art, get into Ghanaian police uniforms or whatever, or, if you're doing graphic design, you should subscribe to Modern Dog magazine. It'll all slot together smoothly. (Also: don't get hammered on wine and lager every night. Try Schloer, it tastes better.)
What other university experiences helped you on your way to what you're doing now?
I met friends who I work with and have a laugh with today and I think they're much more important than any lesson or teacher I had. I worked like an academic beast on the course but it was really just a sort of backdrop to meeting and chatting with good people.
I also made little photocopied short story publications. One was called Gingerbread Cockerel which I left stacks of here and there. Nobody was interested. It was a really shitty publication. Still, that got me started on making my own books and printed things which are now 0.1% better.
What are the inspirations and resources that you would share with your student self?
The British Library would've been really handy in Liverpool, I think every city should have one of those just as a basic requirement. I would've appreciated the artists' bookshop Printed Matter (in New York) relocating to the Cavern Club too. My favourite book is probably Six Years: The dematerialization of the art object by Lucy Lippard, I wish someone had shown me that. It's full of ideas. Every film by Cassavettes, Bergman and Fassbinder. If Kickstarter had been around I could've got funding for all kinds of long forgotten projects. Every In Our Time podcast. Leonard Bernstein's music lectures from Harvard. All Cabinet magazines, maybe up to the year 2020. Warhol's Diaries, Groucho Marx's Letters, CF's Powr Mastrs etc etc. etc.
- Best of the Web is here, and so is the weekend!
- Animator Saiman Chow's trippy idents for Adult Swim's Rick and Morty
- Friday Mixtape: Legendary record label, 4AD
- Risograph photograph journal, This is the Same Ocean, returns with a sixth issue
- Illustrator Gizem Vural impresses us with attention-grabbing personal work and commissions
- Colophon Foundry re-releases its road-sign inspired typeface, Montefiore, with new specimen
- Jon Burgerman on his utterly brilliant Instagram experiments
- The photos Juergen Teller took while waiting for Rihanna
- Animator and director James Curran's amusing 30-day Gifathon project in Tokyo
- "Before I was a graphic designer I had nearly no idea what one was": meet Austin Redman
- Meet Berlin-based studio Büro Bum Bum
- Matthew Raw: the east London artist making clay great again


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Organic Hojicha T-Bags ingredients: Green Tea Leaves.
Made in a dedicated nut free factory.
Green Tea Leaves.
Made in a dedicated nut free factory.
Hojicha is a pleasing light tea and the most popular everyday drink in Japan.
It is prepared at Nagata Chaen, Kyoto, from select green tea leaves that are steamed and then gently roasted to produce the distinctive hojicha flavour and aroma. As the leaves are left to grow longer than for sencha they have a lower caffeine content and because they are roasted they have less astringency.
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Mountain house decor
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This modern retreat is as an ideal place take in some fresh mountain air and unwind in front of a roaring fire. Inside, the sleek modern dwelling soaks up its rustic landscape though towering windows, while vaulted ceilings brighten wood-paneled spaces with a wealth of natural light.
Mountain House Décor Wood Sign "Advice From A Mountain" Poem Vintage Rustic Distressed Hand Painted If you would like another color please let us know. Sizes: and and Colors: pain
Wood mountain shelf, wood mountain keyrack by ParkinHandmade on Etsy
House Blend: Snowmass Home Brings Edge to the Mountains via Luxe | The English Room
mountain timber, it's tile!
Reclaimed Wood Wall Art Mountain Scene, Mantel Art, Cabin Decor, Rustic Style, Cozy, Over Sized Wooden Mural, Natural Wood Stained by HollyBeeandCompany on Etsy https://www.etsy.com/listing/480886833/reclaimed-wood-wall-art-mountain-scene
Antlers, Ski House Trend- Mountain Modern on www.CourtneyPrice.com
Rustic Kitchens in Mountain Homes-05-1 Kindesign
Exquisite rustic mountain retreat in California: Ski Slope More
I wonder how many years those sinks would have before needing replaced. Love it.


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8 keer stoere budgetideeen met multiplex
loft bed with stairs... seems sturdy enough too :)
Gallery.ru / Фото #70 - Выборочно - Ulka1104
The corner counter space behind the sink was put to good use with this customized butcherblock top. The knife storage area is enclosed below the countertop to prevent accidents. A utensil storage bin was recessed into the butcher block and can hold either pot scrubbers or often-used cooking utensils.
Gallery.ru / Фото #6 - 81 - vikavitaminka1981
Gallery.ru / Фото #4 - 10 - kento
Gallery.ru / Фото #2 - DFEA #5 june-july 2009 - ingulja
Possibly add storage to sofa table behind couch. Instead of lid opening up to hit the wall, I would have it up up from left to right or have a centerfold where it opens left/right & right/left at the same time
Fornisce gratuitamente caricamento delle immagini e di hosting di integrazione per forum. Immagine di hosting e condivisione di foto per i siti web e blog.


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Welcoming Refugees is the Lord's Work
Have you ever had a moment when you just knew the Holy Spirit was at work right in front of you? When your spine tingles and your eyes grow wide? I experienced one of those sacred encounters in a Catholic school basement in Cherry Hill last year, and I'll never forget it.
I was moderating a panel of folks who work for our Catholic Charities' refugee resettlement program. They welcome individuals and families who are fleeing violence and persecution around the world and help them adjust to their new lives here in South Jersey. Two of the panelists were former refugees themselves who now work for the program, including a lovely man named Francis, who is originally from Burma (now called Myanmar).
At the start of the program, I told the crowd that the refugees who move here are living and working and going to school right alongside us, whether we knew it or not. The panel's goal was to help raise awareness of the work Catholic Charities is doing and share with attendees how they could get involved. How might we all be good neighbors to these newly arriving members of our community?
We took a short break in the middle of the event, and I made small talk with Francis.
"So, where do you live?" I asked.
He told me.
"Wait, where?" I replied. My spine tingled and my eyes grew wide.
It turned out Francis and his family lived right around the corner from me. They were my literal neighbors. I drive past their place every day. I had no idea.
Read the rest of this column at the Catholic Star Herald.
Social Justice Lessons of Christmas
Every Christmas morning, my friend Sean's parents would load their three sons into the family car and head to a local soup kitchen. Sean and his brothers would help out by putting napkins and flatware on the tables, then a hot meal would be served and gifts distributed to the patrons. Sean's dad sometimes dressed up as Santa Claus.
On the first day back from Christmas break one year during middle school, Sean's teacher asked the class what they had done over the holidays. "We served a meal at the soup kitchen in the morning and then we came home and celebrated," Sean told his class. An awkward silence followed. Sean could tell that kids around the room were staring at him.
"That was the first time it occurred to me that this was not the way most of my friends spent their Christmases," Sean remembers. "One of my favorite parts about serving was that it wasn't a big deal. My parents really did a good job of integrating it into our holiday traditions. It was just something we did."
For many of us, the Advent and Christmas seasons are times when we feel an especially strong pull to reach out toward those who are in need. Why? Maybe one reason is that while Christmas is supposed to be full of joy and togetherness, we realize that there are so many people in the world who are hurting and lonely, and we feel called to close that gap. Sean's family surely responded to this call in a powerful way.
One thing I love about the Christmas stories found in the Gospels is that they so clearly affirm the season's tradition of compassion. The stories are chock-full of love, justice, and God's special concern for those who are poor and vulnerable. Let's explore these themes by focusing on a few of the Christmas season's central characters: Mary and Joseph; the Christ-child; and the shepherds and Magi.
Mary and Joseph
It's impossible to imagine. The Virgin Mary – a devout teenager, not yet married to Joseph – is visited by the angel Gabriel and told she will bear the Son of God. At first, she is "greatly troubled" by this unexpected news. Mary, after all, knows the punishment other unwed mothers have faced in her community: execution by stoning.
But, drawing on the deepest well of faith ever known, Mary says yes to God's plan. She says yes to life.
This time of year, I spend a lot of time thinking about other mothers who are facing unexpected pregnancies, and wonder about the trepidation many of them must be feeling. I pray that our communities of faith can be places of welcome where all parents – single and married, well-off and struggling – feel supported in their choice for life.
Mary found this sort of radical hospitality in Joseph. When he learned of Mary's pregnancy, his first instinct was to divorce her quietly, protecting her from shame and violence. Then, when an angel of the Lord appeared to him in a dream and told him not to fear, but to care for Mary and her unborn child, he took Mary into his home.
Their journey together took them to Bethlehem and then, in the Gospel of Matthew's account, into Egypt to escape the murderous King Herod. This must not be forgotten: The Holy Family was a refugee family. How relevant and painful it is to reflect on that fact against the backdrop of the world's current refugee crisis.
On the Feast of Our Lady of Guadalupe, I went to a prayer service for migrants and refugees at Catholic Charities' headquarters in Camden. The room was filled with Catholic Charities staff members and recently resettled refugees who had just finished an English class. Some of the refugees have arrived here in the past few months from Syria, welcomed by Catholic Charities and working to build a new life in South Jersey. During the general intercessions, prayers for refugees were read by a handful of the refugees themselves who have become confident English speakers. I have had very few, if any, more powerful experiences of prayer in my life. How might the world be different if every Christian around the world consciously saw the Holy Family in each refugee family?
The Christ-child
What can we learn about God from our belief that he came into the world as a baby boy?
God could've come to Earth wielding the power of a superhero, but he didn't. Instead, he came to Earth as the Christ-child, incarnating "transparency, vulnerability, defenselessness," as the great spiritual writer Fr. Ronald Rolheiser puts it. "Ultimately though that power, helplessness and vulnerability, is the greatest power of all because it, and it alone, can transform hearts," Rolheiser writes. "You don't soften hearts by overpowering them. You transform hearts through another kind of persuasion."
There has been a collective, societal obsession with on political and military power this year – even more than usual, perhaps. Christmas is a reminder that God transforms the world (and invites us to join in the work) with gentleness.
Shepherds and Magi
Both of our Gospel accounts of Jesus's birth include visitors to the manger: shepherds in Luke and Magi in Matthew. Why?
Scripture scholar Luke Timothy Johnson points out that shepherds in first-century Palestine were "among the lowest-esteemed laborers." That they are Jesus's very first companions in Luke's Gospel sets the stage for Christ's later ministry, during which he consistently accompanied those who were poor and marginalized. As disciples, the way Jesus spent time is a model for how we might spend time; his priorities should be our priorities.
While the Magi aren't poor or vulnerable the same way the shepherds are, they come from outside the Jewish community, and reveal how the love of God made flesh in Christ embraces all people. The boundaries we build up to separate groups based on race, religion, class, age, ability, and more are not of God. Fr. Gregory Boyle, SJ, cuts to the heart of this idea in his book Tattoos on the Heart. "No daylight to separate us. Only kinship. Inching ourselves closer to creating a community of kinship such that God might recognize it," he writes. "Soon we imagine, with God, this circle of compassion. Then we imagine no one standing outside of that circle, moving ourselves closer to the margins so that the margins themselves will be erased."
If our Christmas season in 2016 is filled with radical hospitality, respect for the dignity of life at every stage, and kinship with the marginalized, our celebration will surely look a lot like the very first Christmas. Or, in G.K. Chesterton's words, "Christmas is built upon a beautiful and intentional paradox; that the birth of the homeless should be celebrated in every home." May every heart prepare Him room! Merry Christmas!
"Fill in the Blank" with Widian Nicola, DSW
When she was eight years old, Widian Nicola moved to the United States from Israel with her Palestinian-Catholic family. She has an incredible, inspiring story of facing the challenges of life as an immigrant in this country with faith, hope, and love. She'll share parts of her story with us at our annual Life & Justice gathering, which is set for Saturday, October 22 at St. Charles Borromeo in Sicklerville. The theme for the day is From Stranger to Friend: Called to Welcome. Learn more and register at camdendiocese.org/mercyministry.
In anticipation of her visit, she played a fun round of "Fill in the Blank."
Name: Widian Nicola
Hometown: Mi'ilya, Palestine and Vancouver, WA (Currently Titusville, NJ)
One thing I love to do is: listen to podcasts!
One person who inspires me is: my spiritual director, Sharon Browning, who has undoubtedly helped me to grow in my faith more than anyone.
My favorite place is: my home. I have several plants on every window ledge and lots of space to rest and relax.
Job: Assistant Professor of Social Work and Licensed Clinical Social Worker
I'm a social worker because: I'm inspired to connect with and love those who are most vulnerable; there seems to be no clearer path to the Divine.
One cool fact about me is: When I arrived to the USA at eight years old, I knew only the numbers 1-10 and "yes" and "no."
If I had a meeting with Pope Francis, I'd tell him: Thank you for your faith and for representing our community with such great love.
Catholic parishes could more effectively be agents of welcome for migrants and refugees by: creating opportunities for intentional dialogue to foster connection. Why not host a multi-cultural event or potluck? Or perhaps an "adopt-a-family" program? Invite newcomers to holiday gatherings at your home and ask if they wouldn't mind sharing a dish from their native country, offer tutoring to help your new neighbors learn English, or create a community pamphlet that lists all the stores where a family might get all their household supplies. In all things, to welcome means to be intentional and extend oneself for the sake of the other.
Celebrate Mother Teresa with a Day of Service
Anjezë (Agnes) Gonxhe Bojaxhiu was born in Albania in 1910. Growing up, she was fascinated by the stories of Catholic missionaries, and thought she very well might enter religious life herself. When she was 18, Agnes entered the Sisters of Loreto, taking the name Sister Teresa in honor of St. Therese of Lisieux.
Eventually, Sister Teresa ended up teaching at a convent school in Kolkata, India (formerly known as Calcutta), where she served for nearly 20 years. While she enjoyed the work, Teresa became increasingly troubled by the poverty, hunger, and violence that surrounded her in the city.
Traveling by train to a retreat on September 10, 1946, Teresa experienced what she would later refer to as "the call within the call."
"I was to leave the convent and help the poor while living among them. It was an order," she said. "To fail would have been to break the faith."
She shifted her ministry to begin working with the poorest of the poor in Kolkata, and started a new religious order called the Missionaries of Charity in 1950. Without knowing it, she had changed from Sister Teresa to Mother Teresa, and the rest is history: She built up a community of sisters that accompanies thousands of the most poor and vulnerable people around the world, extending the compassion and care of Jesus to those who are so often ignored or forgotten.
On Sunday, September 4, Pope Francis will canonize Mother Teresa at a ceremony at the Vatican, giving her yet another name change: Saint Teresa of Kolkata.
I love that image of a "call within a call." Teresa's religious vocation did not end, but its contours changed. I try to listen for those calls in my own life. My primary vocation is as husband and father, but how might God be calling me to live out those vocations more deeply and faithfully as an employee, neighbor, or friend? Do I have the trust that Teresa had to try something new that's worthwhile but risky? Mother Teresa's witness is compelling, but so very challenging.
At the annual Romero Lecture sponsored by Camden's Romero Center Ministries a few years ago, social ministry expert and founder of JustFaith Ministries Jack Jezreel led the audience through a thought experiment. "If you can imagine Mother Teresa standing in front of the room, I picture most of us looking admiringly at her, applauding," he said. "Meanwhile, we're looking out of the corner of our eye for the exit, backing up slowly, so as not to be too noticeable – all the while applauding. We admire her, but we want no part of her."
Mother Teresa's ministry makes us uncomfortable, Jack said. She and her sisters worked with the desperately poor and dying. She did not a run a back-to-work program; there were no traditional success stories. To most of the world, how she spent her life makes no sense. Why would we want to be a part of that?
Some people, Jack said, are able to pass up society's version of "the good life," cross over the boundary and enter into the reality of Teresa, the experience of universal caring that embraces the needs of all. "If somehow we can cross the boundary and engage in the mystery of faith and love, what opens up is a whole new world, a whole new vocabulary, a whole new set of touchstones for life's living," he said. "Once people make it across that boundary for the first time or the second time, they do not want to go back to the old ways."
A move might like this might seem overwhelming or just flat-out impossible. We're busy with all sorts of obligations and activities. But sometimes, taking just a small step in the direction of compassion can provide the spark the Holy Spirit needs to transform us into disciples who are empowered to live as Mother Teresa lived.
On Saturday, September 10, you're invited to take a small step together with Catholics from all over the diocese as we spend a day in service to the community to celebrate Mother Teresa's canonization. We'll gather for opening Mass in Collingswood and Atlantic City, and then head out to serve with community groups like Catholic Charities and local nursing homes, food banks, and shelters. Disciples of all ages are encouraged to attend; visit www.camdendiocese.org/motherteresa to learn more and to register.
The date of the service day just so happens to be the 70th anniversary of Mother Teresa's hearing her "call within a call." What a fantastic occasion to participate in her legacy of love in action. And who knows – maybe you'll hear a call that day, too.
Questions about the event? Email firstname.lastname@example.com.
Amoris Laetitia and Social Justice: Ten Quotes from Pope Francis' Exhortation
Pope Francis' much-anticipated apostolic exhortation on the family, Amoris Laetitia, does not disappoint. It is an incredible work that is full of good advice for both families and church leaders, delivered with theological richness and pastoral sensitivity. Do read the whole thing if you can.
A lot has already been written on many of the key elements of the document, but what struck me while reading it is how clearly Pope Francis connects family concerns with social concerns. He argues that families are only able to flourish if our societies are set up to support them.
This approach called to mind a great quote by St. John Paul II, who said, "As the family goes, so goes the nation, and so goes the whole world in which we live." Part of Pope Francis' emphasis in Amoris Laetitia could be summed up by flipping that idea around: As society goes, so goes the family. They are complementary ideas.
Here are ten quotes from the exhortation that connect particular social issues and our call to work for justice to family life. I've listed them by theme, and include each quote's paragraph number in brackets.
1. Dignity of Work
Labour also makes possible the development of society and provides for the sustenance, stability and fruitfulness of one's family: "May you see the prosperity of Jerusalem all the days of your life! May you see your children's children!" (Ps 128:5-6)….This having been said, we can appreciate the suffering created by unemployment and the lack of steady work, as reflected in the Book of Ruth, Jesus' own parable of the labourers forced to stand idly in the town square (Mt 20:1-16), and his personal experience of meeting people suffering from poverty and hunger. Sadly, these realities are present in many countries today, where the lack of employment opportunities takes its toll on the serenity of family life. [24-25]
2. Care for Creation
Nor can we overlook the social degeneration brought about by sin, as, for example, when human beings tyrannize nature, selfishly and even brutally ravaging it. This leads to the desertification of the earth (cf. Gen 3:17-19) and those social and economic imbalances denounced by the prophets, beginning with Elijah (cf. 1 Kg 21) and culminating in Jesus' own words against injustice (cf. Lk 12:13; 16:1-31). [26]
3. Affordable Housing
The lack of dignified or affordable housing often leads to the postponement of formal relationships. It should be kept in mind that "the family has the right to decent housing, fitting for family life and commensurate to the number of the members, in a physical environment that provides the basic services for the life of the family and the community". Families and homes go together. This makes us see how important it is to insist on the rights of the family and not only those of individuals… At times families suffer terribly when, faced with the illness of a loved one, they lack access to adequate health care, or struggle to find dignified employment. [44]
4. Forced Migration
Furthermore, forced migration of families, resulting from situations of war, persecution, poverty and injustice, and marked by the vicissitudes of a journey that often puts lives at risk, traumatizes people and destabilizes families. [46]
5. Poverty
The problems faced by poor households are often all the more trying. For example, if a single mother has to raise a child by herself and needs to leave the child alone at home while she goes to work, the child can grow up exposed to all kind of risks and obstacles to personal growth. In such difficult situations of need, the Church must be particularly concerned to offer understanding, comfort and acceptance, rather than imposing straightaway a set of rules that only lead people to feel judged and abandoned by the very Mother called to show them God's mercy. [49]
6. Women's Rights
In this brief overview, I would like to stress the fact that, even though significant advances have been made in the recognition of women's rights and their participation in public life, in some countries much remains to be done to promote these rights…The verbal, physical, and sexual violence that women endure in some marriages contradicts the very nature of the conjugal union. I think of the reprehensible genital mutilation of women practiced in some cultures, but also of their lack of equal access to dignified work and roles of decision-making. [54]
7. Protecting the Unborn
Here I feel it urgent to state that, if the family is the sanctuary of life, the place where life is conceived and cared for, it is a horrendous contradiction when it becomes a place where life is rejected and destroyed. So great is the value of a human life, and so inalienable the right to life of an innocent child growing in the mother's womb, that no alleged right to one's own body can justify a decision to terminate that life, which is an end in itself and which can never be considered the "property" of another human being. [83]
8. Solidarity
Families should not see themselves as a refuge from society, but instead go forth from their homes in a spirit of solidarity with others. In this way, they become a hub for integrating persons into society and a point of contact between the public and private spheres. Married couples should have a clear awareness of their social obligations. With this, their affection does not diminish but is flooded with new light. As the poet says:
"Your hands are my caress,
The harmony that fills my days.
I love you because your hands
Work for justice.
If I love you, it is because you are
My love, my companion and my all,
And on the street, side by side,
We are much more than just two". [181]
9. The Family as a School of Mercy
"The family is thus an agent of pastoral activity through its explicit proclamation of the Gospel and its legacy of varied forms of witness, namely solidarity with the poor, openness to a diversity of people, the protection of creation, moral and material solidarity with other families, including those most in need, commitment to the promotion of the common good and the transformation of unjust social structures, beginning in the territory in which the family lives, through the practice of the corporal and spiritual works of mercy". [310; quoting the Synod Fathers]
10. The Family as Transformer of the World
When a family is welcoming and reaches out to others, especially the poor and the neglected, it is "a symbol, witness and participant in the Church's motherhood". Social love, as a reflection of the Trinity, is what truly unifies the spiritual meaning of the family and its mission to others, for it makes present the kerygma in all its communal imperatives. The family lives its spirituality precisely by being at one and the same time a domestic church and a vital cell for transforming the world. [324]
Pascasie from CRS Rwanda is coming to Camden (And she sent an awesome video greeting to us)
Pascasie Musabyemungu works for Catholic Relief Services in Rwanda, her native country. She's visiting the United States this Lent to share her story and talk about the work of CRS, and she'll be stopping by the Diocese of Camden on Wednesday, March 9, at 2:30 pm.
Download a flyer for the event here.
She's so excited for her visit to South Jersey she recorded a special video greeting just for us! Check it out:
Event Details:
Pascasie Musabyemungu (CRS Rwanda) Special Event
Wednesday, March 9, 2016 | 2:30 — 3:30 pm
Diocese of Camden Pastoral Center (3rd Floor)
15 N. 7th Street, Camden, NJ 08102
Free admission
Registration required:
Email firstname.lastname@example.com to RSVP.
A bit about Pascasie:
Pascasie Musabyemungu has a mission: to work for peaceful, healthy communities in her home country of Rwanda.
Pascasie, who has worked with Catholic Relief Services for more than 15 years, will share stories of people whose lives have improved dramatically since they began participating in CRS programs.
Pascasie works with the hungry, people living with HIV, orphans, vulnerable youth, the elderly and people traumatized by a region rife with conflict and social division. The Women Building Peace Project Across Borders brings together 60 women traders to promote peace. The women serve as critical conduits of information, breaking down harmful stereotypes and preconceptions.
Pascasie was born and raised in the eastern region of Rwanda. When she was a child, her family provided food and essential living supplies to patients in need at a clinic near their home. Additionally, she and her siblings spent two afternoons each week caring for an elderly couple.
In 1994, Pascasie and her family lived through the horrors of the Rwandan genocide. These experiences profoundly influenced her decision to work for CRS and help others in her community.
Pascasie resides in Kigali with Laurent Twahirwa, her husband of more than 30 years. They have four daughters—Josianne, Carine, Christelle and Samantha—and four grandchildren.
Ten Ways to Practice Mercy During the Jubilee Year
In late November, custodian Jose Moran set up the Christmas manger at Holy Jesus Child Church in Queens, NY. He took a lunch break and then returned to the church. What he found there was surprising, to say the least: a newborn baby was crying in the manger – so young, his umbilical cord was still attached. The parish has accepted the infant with open arms, with multiple families volunteering to adopt him.
Fr. Christopher Heanue is an administrator at the parish. "I think it's beautiful. A church is a home for those in need, and she felt, in this stable — a place where Jesus will find his home — a home for her child," he told the New York Times. "Pope Francis has called this a year of mercy in the church…What better way to be merciful than to find a home for those in need."
The Jubilee of Mercy started on December 8. Inspired by the example of Holy Jesus Child Church, here are just 10 ways you might try to practice that type of mercy during the year ahead.
1. Pray for those who are hungry before every meal.
Prayer changes things – including the heart and mind of the one who prays. Working on this simple habit unites us to those who are hungry should lead to fruitful action, like wasting less and giving more to organizations that fight hunger, for instance
2. Get to know someone living on the margins.
There are number of social service agencies in our region that facilitate encounters with those living on society's peripheries: the poor, the homeless, the lonely. Connect with one of these organizations and spend time with someone the agency serves. Get to know his or her name and a bit about their story, and share of yourself. As we see in parables like the Good Samaritan, mercy involves physically moving toward those who suffer – not just writing a check or dropping some old clothes in a donation box.
3. Learn more about a pressing social issue.
What makes you say, "The world shouldn't be this way"? Pick an urgent issue threatening human dignity in the world right now. Learn more about it and research what Church leaders have said about it. Then, learn about how you can be involved in possible solutions to the problem, in a small or large way.
4. Memorize the corporal and spiritual works of mercy.
Memorization is big for us Catholics – we memorize prayers, Mass responses, the dates of particular feast days, the pattern of the rosary, and more. We don't memorize just to be able to repeat things in a rote way, but so these key ingredients of our faith become fully integrated into our lives. They become part of us. I know I still don't have the works of mercy memorized. Maybe I'd be better at living them if they were more fully present on my mind and in my heart.
5. Read Mercy in the City by Kerry Weber.
Speaking of integrating the works of mercy into our everyday lives – journalist Kerry Weber committed to practicing all the corporal works of mercy during a Lenten season a few years ago and recorded her experiences in this book. Her authentic witness is inspiring and makes for a great read. Perhaps it'll spark some good ideas in you.
6. Visit a sick or elderly friend or relative.
When Pope Francis talks about people who are often forgotten or even discarded as part of our "Throwaway Culture," he almost always mentions the elderly. Loneliness is a real epidemic in our culture. If you don't have someone close you to you who you can visit, connect with the activities department at a local nursing home and see how you might be able to get involved.
7. Advocate for more just public policy at a lawmaker's office.
Mercy involves spending time with those who are suffering. It also includes raising your voice on their behalf. One powerful way to make your voice heard is to visit local lawmakers' offices to advocate for more just legislation. To learn about pertinent legislative issues that affect those on the margins of society, and how the Church suggests you respond to them, visit the website for the movement Catholics Confront Global Poverty at www.confrontglobalpoverty.org.
8. Buy Fair Trade.
Here's another less-obvious way to practice mercy – in your role as a consumer. Fair Trade products – which range from coffee and tea to clothing and jewelry – are produced by fairly-paid adults around the world. By buying Fair Trade, you can help give a hand-up to those living in poverty in developing countries. Find Fair Trade coffee in your local grocery store. Your parish can even host a Fair Trade sale through a partnership with Catholic Relief Services; visit www.crsfairtrade.org to learn how.
9. Watch you language.
The words we use shape how we view the world. When it comes to mercy, it's easy to see its practice as a top-down thing in which the more-fortunate generously reach down to give something to the less-fortunate. But in God's eyes, we are all equally valuable and loved. So, here are some words I'd suggest steering clear of when talking about the practice of mercy: give back; helping the less fortunate; make a difference. Instead, try things like: build relationships; mutuality; kinship.
10. Start or strengthen a Life & Justice Coordinating Team at your parish.
In a document called Communities of Salt and Light, the bishops of the United States write, "The local parish is the most important ecclesial setting for sharing and acting on our Catholic social heritage." What does this mean? We can't leave the work of mercy to Catholic Charities, Catholic Relief Services, Catholic healthcare, and other similar organizations. These are all great and essential institutions, of course. But as the parish is where faith is meant to be lived in entirety, the parish must be engaged in organized, efficient, widespread works of mercy. A well-formed coordinating team is the best way to empower the faithful to get involved. My office offers training sessions to help get you up and running. Email (firstname.lastname@example.com) or call me (856.583.2910) to learn more.


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If you are interested in submitting your information for the commercial project for June 2017, please complete the following form. The project is for a commercial video shoot for a large-scale apartment company, that will entail acting only, no vocals. The premise is a "day in the life" of a person/couple who go about his/her/their "average" day, from making breakfast to going off to work in a car. Then, upon coming home, some activities of entering again, lounging for a few moments, like putting feet up on an ottoman and turning on the tv or reading a book, making a call to some friends about tonight's activities and hanging out. Go to the tennis court, pool, or otherwise, come back, then go to the local townsquare to meet your friends. In the early evening, venturing to the local townsquare and have something to eat, maybe a (fake) drink, etc. The purpose is to effectively simulate a workday to having fun and relaxing in the evening with friends.
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MY Mr Knightley: Making a Regency Tailcoat
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Things to do in Midleton & Area
- The Jameson Experience
- Old Midleton Distillery
- Trabolgan Holiday Village
- Birds of prey Educational Centre at Trabolgan
- Ballymaloe Cookery School
- Ballymaloe Gardens & Farm walk
- Market Green Shopping Centre
- Midleton Farmers Market – Saturday's
- Fota Wildlife Centre
- Fota House & Gardens
- Shanagarry Design Centre
- Ballycotton Fishing Village
- Ballycotton Island Lighthouse Tours
- Barry's Court Castle, Carrigtwohill
- Leahys Open Farm, Dungourney
- Loughaderra Lake – Castlemartyr
- Cloyne with its 11th century round tower
- Swell Surf School – Inch Beach
- East Cork Adventure Centre – Upper Aghada
- Eco Adventures – Aghada
- Ballyannen Woods
- The Gate Cinema – Midleton
- Movie Junction Drive in cinema – Carrigtwohill
- Ballyseedy home & Gardens – Carrigtwohill
- Stephen Pearce pottery – Shanagarry
- The William Penn Room
William Penn was an English real Estate Entrepreneur, Philosopher, Early Quaker and founder of the Province of Pennsylvania, the English North American Colony and the Future Commonwealth of Pennsylvania. William Penn resided briefly in Shanagarry Castle which are on the grounds of Shanagarry Design Centre.
Trabolgan Easter Offer
Looking for a fun day out for all the family this Easter Break! Well at Trabolgan Holiday Village in East Cork they have something for all the family to enjoy from their indoor pool paradise to their amazing characters and range of adventure sport activities. With discounted tickets from just €5 per person for day visitor admission don't miss out book your ticket TODAYread more
The Half Light Gallery Open Evening
Our newest member The Half Light Gallery, 97 Main Street, Midleton are having their open day on Friday 31st March. You are invited to drop in during the day to help them celebrate or that evening from 7.30pm. They are also offering 20% off all original art for this week only, sale ending Monday 3rd Aprilread more
Light It Up Blue
The ninth annual World Autism Awareness Day is April 2, 2017. Every year, autism organizations around the world celebrate the day with unique fundraising and awareness-raising events. How will you celebrate?
Use #LIUB to share your experience across social media and help light the world up blue this April!read more
Contact Us
Address: 61/62 Main Street, Midleton, Co. Cork
Tel: (021) 4613 483
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Chamber Office Opening Hours:
Mon – Fri: 9.30am to 5pm


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Armenians in Syria
As Europe's refugee crisis unfolds, Armenia says it has hosted thousands of Syrians, particularly those from the Christian- Armenian community.
After the genocide, Armenians fled to Aleppo, Syria. Now, some in the community have found their way back, including one family that has.
See pakistan-karachi.info for more about - Armenian in Syria.


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This charming pattern is a part of The Rivendale Collection by Sally Giblin. Pattern includes instructions for stitchery and instructions for bolster. Finished size is 23" x 7".
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