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Listing ID: 20170483
Price: $559,999
Status: PENDING CONTINGENCY
Address: 20238 Pine Mountain Drive
City: Groveland
State: California
Postal Code: 95321
Bedrooms: 4
Total Baths: 3
Full Baths: 3
Square Feet: 2,144
Acres: 1.720
County: Tuolumne
Fantastic Lake Front home on 3 merged lots with a grand total of 1.72 acres with room to have your own dock and beach area. This Lake property makes a wonderful full time residence or vacation rental property! Home sits approx. 120 ft from main road and has tons of parking spaces for guests, RV parking and more! This 2 level cabin feel home has four bedrooms, 3.5 baths, boasting 2144 sq feet. Water photo's taken at last stake on wide cove area for the water veiw. Four newer Anderson patio windows opening to the spacious deck from the Great Room with vaulted ceilings, stone fire place with airtight wood stove. Spacious Living area with lots of light & lovely lake views, giving you a feeling of seclusion while you relax from the everyday hassles~ in your mountain retreat! Updated kitchen with silstone antibacterial solid counter tops, newer stainless steal appliances. Entry level with half bath and spacious master suite and master bathroom with walk in closet. Downstairs 3 Bedroom 2 full bath with extra large Bonus Room, laundry area. Walk out to carport area. 10x6 shed with workbench and power outlets. Just a short distance from the Lake Lodge Beach! Home decor decorated by Lynn Bonander. Located in our wonderful gated community of Pine Mountain Lake not far from Yosemite National Park! Owner will finance $430,000 @ 4.25% payable $2,115.34 or more with balance due 4 years and 6 months.
Primary Features
Air Condition: Evaporative Cooler
Area: 018-PINE MOUNTAIN LAKE HOA
County: Tuolumne
Electricity: 110V, 220V
Elementary School: Tenaya
Financing: Owner Financing
Fireplace: Air Tight, Stone, Circulating
Garage: 1 Carport
Heat: Baseboard, Wall Electric, Wall Propane, Woodburn
High School: Tioga
Patio/Deck: Deck
Property Type: Residential
Year Built: 1986
Location Information
Address 2 Lot Number: 59
Address Search Number: 20238
Common Amenities: Beach, Fishing, Hiking Trails-Par Course, Play Ground, Rec. Club-Country Club, Tennis Courts
Elevation: 2800
Road: Paved, Private
Sewer: Public
Sub Area: 18-PML UNIT 04
Zoning - Tuolumne: R-1/Single Family Res
Age Range: 26-39 Years
Approximate Age: 31
CC&R Number 1: yes
Easements: As of Record
Energy: Ceiling Fan, Double Pane, Insulated Floors, Insulated Walls
FIPS Code: 06109
HOA 1: yes
HOA 1 Name: Pine Mountain Lake Association
HOA 1 Phone: 209-962-8600
Included: Most furniture included plus Washer, Dryer and Kitchen Appliances-Excludes: (Two Coffee Tables and 1 End Table, Dining Table and Chairs).
Legal Property Description: Unit 4 Lot 59 Pine Mountain Drive
Ownership: Private
Property Profile: Lake Front Lot
Status Category: PENDING
Type: Single Family
Interior Features
Amenities: Cathedral Ceiling, Lk Membership, Open Beam Ceiling, Smoke Alarm, Tile, Wet Bar
Bathrooms: Closeted Toilet, Dual Lavatories, Hall, Jetted Tub, Separate Shower, Tub/Shower, On Entry Level, Tub
Dining Room: Breakfast Area, Open, Great Room, On Entry Level
Floors: Hardwood, Vinyl, Wall to Wall Carpet
Half Baths: One
Kitchen Amenities: Breakfast Bar, Compactor, Dishwasher, Disposal, Microwave, Propane, Range & Oven F/S, Refrigerator, Stainless Appliances, On Entry Level
Laundry Room: Dryer Hook Up, Inside, Washer Hook Up, Washer Included, Dryer Included
Levels: Two Levels
Living Room: Conventional, Great Room, With Heat Stove, On Entry Level
Master Bath: Closeted Toilet, Dual Lav, Jetted Tub, Tub/Shower
Master Bedroom: On Entry Level, Private Deck/Patio, Suite, Walk-in Closet
Other Rooms: Bonus Room, Other/Remarks
SqFt Range: 2001-2500
Television: Antenna
Utilities Available: Cable, Electric, Overhead, Phone, Propane, Sewer, Water
Water Heater: 30 Gallon, 50 Gallon
External Features
Construction: Site Built
Driveway: Blacktop, Down, RV Parking, See Remarks
Exterior: Wood
Foundation: Concrete
Landscape: Natural
Lot Coverage: Brush, Clear, Mostly Open, Some Trees
Out Buildings: Shed, Storage
Propane Tank: Leased
Property Corners: All
Roof: Tile Types
Style/Construction: Cabin/Rustic, Conventional
Topography: Down slope, Gentle, Level
View: Lake, Lakefront
Water: District
Water Feature: Lake/Pond, Private Lake, Private Pool
Financial Details
Asking Price: 559999
HOA 1 Monthly Dues: 176
Sale/Rent: For Sale
Zoning Info
Listing courtesy of PAUL S. BUNT, REAL ESTATE, Krystal BiggerBased on information from the Tuolumne County Association of REALTORS® (alternatively, from the Tuolumne County MLS) as of Friday, April 28th, 2017. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.
Request More Information - Listing ID 20170483
Data services provided by IDX Broker


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Yesterday we mentioned something "Avengersy" coming from Warren Ellis and Mike McKone this summer from Marvel.
And as with, well, just about everything I seem to post right now, a couple of hours later I suddenly get more information.
In this case it seems that Ellis and McKone's book is just one of a series of new original graphic novels from Marvel from what is described as "A-list creators".
Marvel haven't had a great history for producing original graphic novels, though the Season One hardovers from the last couple of years were notable exceptions. However, unlike DC's similar Earth One titles however, they didn't exactly light up the charts. The belief is that this may have been down to Greg Pak, Peter David and Cullen Bunn being less bankable writer names that Geoff Johns and JMS.
So not only will this line feature Warren Ellis and Mike McKone, but we can start to speculate as to who else… Joss Whedon? Brian Bendis?
Neil Gaiman?
- There Will Be Two America #4 Comics In Comic Stores A Week Of Each Other - April 28, 2017
- Two Iowa Comic Book Stores Close, One Week Of Each Other - April 28, 2017
- Jae Lee And Brian Stelfreeze FOC Covers For Jim Henson And Victor LaValle.. - April 28, 2017
- A Box For Archie Comics' Spider-Man Digests In Time for Spider-Man Homecoming - April 28, 2017
- Oh My Days! Bill Potts' First Titan Comics Doctor Who Appearance, On Free Comic Book Day - April 28, 2017

subset: commoncrawl


text: Current Home PageCalendar Rollup Image Share Month All April May Search May Morgan Stanley, GEMS Conference, London 15.05.2017 - 18.05.2017 April 2017 Q1 Investor Call 26.04.2017 - 27.04.2017 2017 Q1 Results Announcement 25.04.2017 - 26.04.2017 HtmlContent* Dates are subject to change. Before the official disclosure of the periodical results, Turk Telekom implements a practice called "Silence Period" when the people who have access to insider information abstain from sharing such information with the public. This Silence Period starts six weeks before the announcement of the year end results and two weeks before the announcement of the quarterly results and ends when these results are disclosed. In addition, Turk Telekom implements another practice called "Blackout Period" when the people who have access to insider information are prohibited to trade the shares of Turk Telekom. This Blackout Period starts with the Silence Period and ends one business day after the Silence Period. Did you find this content useful? Please add your personal notes These notes are only visible to you. Title Note SUBMIT Your notes on this page


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TED (Technology Entertainment and Design) is a series of non-profit conferences that are devoted to "ideas worth spreading". Delivered by many celebrated speakers, the talks are divided into 6 major headings – including Science, Technology and Global Issues – and are now available free on-line. Under Science you will find talks that include, "Discovering ancient climates in oceans and ice" and "A tool that finds 3x more breast tumours and why it's not available to you".
Riveting talks by remarkable people
13 January 2011 by Tommy McGreevy


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China's newest Homemade Aircraft Carrier Secures off-shore power
China has celebrated its second aircraft carrier which is known to a homemade one built within less than four years.
By Ruth Wang
on March 11, 2017 06:03 AM
Although we know the benefits of Bible reading and its importance through Paul's word in 2 Timothy. 16-17, we do not regularly read the Bible in real life. We often make all kinds of plans about reading it, reciting the Bible each year; but, we always fail to carry out these plans in the end.
Why is it so difficult to keep reading the Bible? Do you find any of the following reasons the cause why you find it difficult to read the Bible?
1. Constant spiritual battles
According to Paul, we are not fighting against flesh and blood, but with spirits in the air. Reading the Bible is not just a personal matter. It also involves spiritual battles. We need to keep it in mind that Satan does not want you to read the Bible to become familiar with God's word. So we need to be alert all the time against the temptations of Satan.
2. Too busy
Studying God's word takes time. Many people lack time for various reasons, including being busy making a living and doing secular works. Some of which are legal, while others are sinful. The greatest killer in our society is becoming busy. We do not need to be busy but become effective, removing what is useless and sinful from life. Similarly, we need to have quiet time before God to seek for his guidance and revelation.
3. Lack of skills
Many people do not know how to study the Bible. They have not been trained nor have they found good and effective ways to read and study the Bible so that they can receive good guidance from the Bible. If it takes skills and learning for us to use computers and phones, how much more training and study do we need to study the Bible?
4. Replace reading the Bible with spiritual books
Many people love reading spiritual books. Though they can teach us and help us in knowing the truth, they cannot replace the Bible. You need to read the Bible and meditate by yourself, believing that the Holy Spirit will help you.
5. Spiritually lazy
A great number of Christians are lazy in reading the Bible. They have concerns and struggles regarding some trivial issues in life, throwing the Bible aside. The underlying reasons are a reckless life, indifference and laziness. The fact that modern people do not like reading is the main reason for many distortions of the Bible. In the internet age, we spend so much time on social media which provides us with no real healthy spiritual food and it must be cut out off our life.
6. Fear laws
For practice means repeated and long-term hard work, many people think of it as legalistic. When reading the Bible, one may find many places where God point out man's sins and judge them. As a result, people do not want to face the Bible in fear of seeing the laws they have violated. But we need to know that the reason that God wants us to know what sins are and that He wants us to desire grace and leave these sins. Our daily spiritual practise is a cold law but a channel for us to experience God's presence so that we may receive more grace and revelation from reading the Bible.
7. Lack a one's own Bible.
Around 600 millions of believers in the world do not have their own Bibles. Most of them cannot have a Bible because of poverty and many Christians are not allowed in their countries. Besides, Christians do not consider it important to have their own Bibles at home, work or anywhere else. Remember to have your own Bible and keep reading it and taking notes which I believe will benefit you greatly in a long run.
Translated by Alvin Zhou
China has celebrated its second aircraft carrier which is known to a homemade one built within less than four years.
Through the Bible, we know how God view babies and little children.
Many of us turn to Holy Bible to know the meaning of adultery and how it affects marriage and causes divorce.
Rev. Wu Bing from Dalian shares four reasons why preachers are poor and proposes that a proper payment system should be considered in love and fairness to solve the problem.
Wuxi Christian Church hosted a charity art auction to aid the poor on April 23.
The local Christian authority is planning to visit and learn about the situation of local Nu believers in Fugong County.
Known classical and contemporary music group American Boychoir is currently in Shanghai for their 2017 China Tour.
Netflix is finally going to China.
Despite the short hiatus, Air China is now offering flights from Beijing to North Korea.
Depression attacks anyone. But it does not mean we won't do our best to avoid and heal it.


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Primary school children across the country have been sitting SATs this week, to prove their grasp of complex spelling, grammar and punctuation rules in a contrived and artificial context. Meanwhile, here at LNS we've been celebrating some wonderful examples of creative writing from children of all ages. […]Read more →
"Education," in the words of John Dewey, "is a process of living and not a preparation for future living." Under the direction of our politicians, our education system demands that children make relentless progress and reach higher targets at a younger age. Rather than meeting the needs […]Read more →


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By now, you've probably gotten the memo that a little bacteria in your food isn't always a bad thing. Some foods contain beneficial live microrganisms like bacteria known as probiotics, which are made through the process of fermentation.
Trend watchers say that probiotic foods are among the most fashionable eats in recent years, but there's actually nothing new about them.
"Our first records of people using fermentation as a way of preserving food go back to 6000 or 7000 BC," says Gail Cresci, PhD, RD, of the Pediatric Research Center and Department of Gastroenterology, Pediatric and Lerner Research Institutes at Cleveland Clinic.
What is new: Our enthusiasm for and understanding of just how good probiotic foods may be for us.
While researcher Elie Metchnikoff first noted the good health of Bulgarians who drank soured milk more than 100 years ago, his findings were largely dismissed as antibiotic drugs came into vogue, says Cresci. "With the knowledge we now have about the gut microbiome and how important bacteria are for our health, probiotics have resurfaced."
Probiotic Supplements Vs. Probiotic Foods
There are loads of probiotic supplements on the market, and no doubt, it's easier to pop a pill than change your diet.
But the health perks of probiotics may lie in part with their interaction with food.
"The benefits people get from fermented foods come largely from improved digestibility, and the nutrients the foods provide," says Benjamin Wolfe, Ph.D., assistant professor of microbiology at Tufts University. In fact, he says, in many cases fermentation adds nutritional value.
As the bacteria chemically alter the food—i.e. turn milk into yogurt—they secrete enzymes, organic acids, and proteins. Some of the potential health benefits of probiotics may be due to these compounds, says Cresci.
For example, metabolites—waste products—produced by the probiotic bacteria during fermentation include nutrients like blood-clotting vitamin K, according to Wolfe.
Freeze-dried probiotic bacteria in a supplement may not always have the same effect. And probiotic foods fuel your body while providing health benefits apart from their probiotic activity.
Another reason to stick with food: Makers of dietary supplements don't have to prove that their products are safe or effective.
How Do Probiotic Foods Help Your Health?
Many benefits are attributed to these microbes—improving digestion, boosting immunity, and helping with weight loss, among others. However, the claims may be overblown and more research needs to be done.
Some evidence does suggest that probiotics can help shorten a bout of diarrhea caused by antibiotics, Clostridium difficile (C. diff), a virus, or contaminated food. They may also improve symptoms of irritable bowel syndrome (IBS). But supplements aren't necessary; in many cases, probiotic foods supply enough good bacteria to help.
So what probiotic foods can you try if you're interested in getting more gut-boosting bacteria? Here are three to consider incorporating into your day:
Yogurt is made when milk has been inoculated with friendly bacteria—usually Lactobacillus bulgaricus and Streptococcus thermophilus—and allowed to rest for several hours at a temperature that invites the microbes to alter the milk's natural sugar called lactose. That process thickens it and producing the sour, tart flavor you expect from yogurt.
It's also what makes yogurt a good choice for those who can't drink milk because it upsets their bellies. The bacteria break down the lactose, which means yogurt is far less likely than milk to cause bloating, gas, and other digestive discomfort in lactose-sensitive people.
"You're essentially using microbes to predigest the food; that makes it more pleasant to eat," Wolfe says.
Look for: Plain yogurts that are made with milk and live active cultures. You can add fruit to sweeten it. If you prefer a flavored yogurt, look for one that's low in sugar. Even plain yogurt has some sugar, but it's naturally present in the form of lactose. A sweetened yogurt, however, can pack as many as three heaping teaspoons of added sugar.
Use it: Take yogurt beyond breakfast by turning it savory. Top a bowl of plain yogurt with chopped tomatoes and cucumbers, black olives, and a sprinkle of the Middle Eastern herb blend za'atar.
The word we now use to refer to it means "sour cabbage" in German, however sauerkraut has been around since the building of the Great Wall of China when workers dined on shredded cabbage preserved in rice wine. Bacteria present on the surface of the cabbage ferment the vegetable's natural sugars into lactic acid, which inhibits the growth of harmful microbes. In addition to healthy bacteria, sauerkraut is also an excellent source of immune-protecting vitamin C. Kimchi, popular in Korean cuisine, is a similar fermented food. It's made with cabbage, but also contains other ingredients and is typically spicy.
Look for: Refrigerated products. Shelf-stable varieties are pasteurized, which kills off the healthy probiotic bacteria. A more potent product will be kept cool. It should be made primarily from cabbage and salt, but seasonings like caraway seeds or other vegetables are okay too.
Use it: To add some tart and crunch to a salad or a quinoa bowl with roasted vegetables.
The process of adding microbial cultures to cooked soybeans results in a dense, chewy cake with a nutty texture, creating a higher-in-protein-and-fiber and some say easier-to-digest meat substitute than vegetarian mainstay tofu.
Look for: Shrink-wrapped plastic packages in the refrigerated sections of health food stores near the tofu and meat alternatives (some conventional grocers are beginning to carry it as well). Some tempehs are made with grains or seeds like barley and flax, which give different types different textures and flavors.
Use it: Slice and marinate for 30 minutes in a mixture of lower sodium soy sauce or tamari, rice wine vinegar, and sesame oil. Pan fry until each side is golden. Serve on top of stir-fried vegetables in place of chicken.


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Needing space quotes
Explore related topics
Not emailing is the hardest thing to do right now. Don't think for a second I've forgotten... You're still the first and last thing on my mind every day :)
Specially if your spouse suffers from bipolar disorder and ptsd...they need their space and alone time...so much going on their head. He will love you more for understanding their moods and tolerance...
Looking for #Quotes, Life #Quote, Love Quotes, Quotes about Relationships, and Best #Life Quotes here. Visit curiano.com "Curiano Quotes Life"!
life is about love, love is meant to be shared #beautiful
Sometimes we all need space away from people that can be difficult and think there saints. It's time to see the light.
Something that is difficult for ENFPs, but critical to our peace of mind.
Honor the space between no longer and not yet. -Nancy Levin Quote #quote…
I am fine. My need for space means nothing more than what it is. The disbelief at how broken our system is, and how narrow minded some people are is more than I can bear some days (pulls cover back over head). These are days when I say, "I'll let you handle this God. This is waaaaaay more than I can handle."
Yes I do. Sometimes my introvert self comes out. Being alone is solitude to me, not a punishment. I enjoy my "Me time alone" maybe a little too much.
We all need space and reflection.


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Explora Copa 2014, Friendship Never Ends, ¡y mucho más!
Copa 2014
Copa 2014
Amish Sour Cream Corn Bread - a great choice, because this bread is simply delicious. Incredibly light, soft and tender, with just a bare touch of sweetness. And so deadly simple. It's really just mix and bake.
The Soccer Fence: A Story of Friendship, Hope and Apartheid in South Africa Bildner, Phil AR Quiz No. 166692 EN Fiction IL: LG - BL: 4.0 - AR Pts: 0.5 AR Quiz Types: RP Book Rating: Not yet rated. After apartheid ended, Hector and a white boy become friends thanks to their shared love of soccer and the Bafana Bafana natonal soccer team.
About Friendships
The Last Summer at Chelsea Beach by Pam Jenoff is the perfect read to send off your summer.
Bubble gum cupcakes!!! summer-ideas
When things are really hard, I think the most meaningful thing you can do for someone is to just show up, whatever that looks like. This
Wrapped up my 2nd research paper of the semester & prepping to present my findings. Hello end of the semester...I've been waiting for you! #GOTshitdone!!


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Serving Greater Chicago, Arlington Heights, Des Plaines, Chicago
Catalyst Builders & Remodelers is the local expert for Basement Finishing, Bathroom & Kitchen Remodeling and more. We proudly service Des Plaines and all of Greater Chicago.
Contact us for a no-obligation estimate for any of our services.
Or call us at
1-844-205-8952 1-773-273-8575
© 2017 Catalyst Builders & Remodelers2000 W Carroll Ave #303AChicago, IL 60612
Contractor ID: TGC011000-8


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US imposes new sanctions on Syria over suspected chemical attackWorld April 24, 21:23
Russian businessman plans to build sailplane to fly around the globe nonstop in 5 daysScience & Space April 24, 19:50
Roscosmos excludes three cosmonauts from space teamScience & Space April 24, 19:34
Russian Foreign Ministry: Terrorists in Syria may get chemical weapons from Libya, IraqRussian Politics & Diplomacy April 24, 19:05
US not ready yet to restart arms control dialog, Russian diplomat saysRussian Politics & Diplomacy April 24, 18:57
Court recognizes Russia's Sports Ministry as affected party in WADA whistleblower caseSport April 24, 18:48
Elephant, giraffe and wildcats found among Muscovites' house petsSociety & Culture April 24, 17:48
Putin calls for setting apart real anti-corruption crusaders from political show-offsRussian Politics & Diplomacy April 24, 16:34
Moscow court turns down Jehovah's Witnesses bid to fight Justice Ministry's banWorld April 24, 16:08
{{element.title}}{{element.heading}} {{element.date}}
BRUSSELLS, September 30. /TASS/. Russia has informed NATO of Moscow's decision to conduct the operation in Syria, the Russian mission at the alliance said on Wednesday.
"The alliance's leadership was officially informed today about the decision," a mission spokesman said.
The Federation Council earlier on Wednesday granted permission to the Russian president to use the country's Air Force in Syria against the Islamic State (IS) terrorist group upon the request of Syrian President Bashar Assad.


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Carlos was good, Kiko was better, flinging lumps of plastic mortar into the crevasses between the beam and ceiling and walls with the skill of a jai alai player. ??Visit Eurostar's website for more information and to buy tickets Media Partners Platinum Partners Gold Partners Silver Partners Bronze Partners Supporters Show dates 09:30 17:30 Tue 7th June 2016 09:30 17:30 Wed 8th June 2016 09:30 16:00 Thu 9th June 2016 Useful links Thinking of exhibiting. ) But, as you've said, the obsession the FETISH over the Wilson single far outstrips its actual artistic worth.
Picked up 2nd coop fairly cheaply from a farm supplies shop nearby, where it had been sitting outside, gently rotting, for quite a while. In terms of personnel, Mark Carne the CEO of Network Rail will survive despite criticism as will Richard Price the boss of the Office of Road and Rail. ??Through one of our Online Home Study courses, you will have the chance to gain those qualifications or skills you need to make progress in your life and career.
Hot ethnic busty slut impaled on black monster tool Feel Free to Take LexPOV Tour Here Busty asian babe riding Lex's cock on this video clip. Though Roscosmos is still investigating the cause of the failed mission, preliminary evidence points to an accident in the third stage of the space craft's carrier rocket,??Russian state news agency TASS reported. ??She then moved back to her native Devon to present Spotlight, the evening news programme, and anchor the Politics Show.


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Arise designs & installs innovative renewable energy solutions to help clients reduce electric utility bills and reduce their carbon footprints.
We specialize in Photovoltaic Solar Energy and Wind Energy systems, and are based in Littleton CO.
Solar companies in your area that will provide you with live pricing online:
Sign up for solar price watch and we will tell you whenever a solar company in your area offers a deal that is cheaper than we have seen before.
Get notified when a new solar system is installed in your area at a cheaper price than we have seen before!
Jim Bartlett and Tim Meisinger exceeded my expectation for the installation of an 8 Kw hour solar array in
Type: Residential Electric
Reviewed: 08/11/2013
Jim & Tim at Arise Energy Solutions were great to work with. I had some difficulties getting the solar
Type: Residential Electric
Reviewed: 11/13/2012
These people are unusually reliable and competent. I`d be happy to talk to anyone looking into PV with them.
Type: other
Reviewed: 10/28/2012
Prior to purchase, I talked with at least 10 potential companies. My goal was not only current cost and
Type: Residential Electric
Reviewed: 10/15/2012
I continue to be very pleased with the whole experience of installing a solar photovoltaic system and
Type: Residential Electric
Reviewed: 11/12/2011
Excellent contractor and I am a fussy person. Went the extra mile to assure an high quality and on time job.
Type: Residential Electric
Reviewed: 11/11/2011
Arise Energy was very professional. They educated me about all the various design layouts and different
Type: Residential Electric
Reviewed: 11/06/2011


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Explore Paint Stairway, Stairway Railings and more!
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How to Paint Stairway Railings - Bower Power
#homemade More
9 Staircase Storage Ideas | Storage Ideas & How-Tos for Closets, Garages, Laundry Rooms & More | DIY
simple home
Step-by-step tutorial on how to remodel a carpeted staircase into one with wooden treads and iron balusters
Style at Home
Fixer Upper: Season-Three Sneak Peek Gallery | HGTV's Fixer Upper With Chip and Joanna Gaines | HGTV
Stacy Jacobi Interiors/. Black high gloss painted stairs
South Shore Decorating Blog: Manic Monday Eye Candy (#4)
Family Room with bar 2


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Marine Weather Warnings - Local Waters Wind Warning
Cancellation of
Local Waters Wind Warning
for Port Phillip.
Issued at 11:28 pm EDT on Wednesday 13 March 2013.
Please be aware
Wind gusts can be 40 percent stronger than the averages given here, and maximum
waves may be up to twice the height.
Weather Situation
A cold front has moved into the Tasman Sea
Cancelled local wind warning for Port Phillip
Winds not expected to exceed 25 knots.
No further warnings will be issued for this event.
More detailed information about local wind speed and direction and wave
information is available in the Local Waters Forecast.
Weather News
Freezing nights to come for Canberra
Night-time temperatures will drop well below average in the Capital from Wednesday.
Warm oceans fuelling late end to big wet season
Warmer-than-normal oceans have contributed to a late end to a big wet season across the southern hemisphere.
Great Barrier Reef: Making clouds brighter could help to curb coral bleaching, scientists say
Marine scientists have upped the ante in their fight to save the Great Barrier Reef from the devastating effects of coral bleaching.


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Office-worthy yet detailed for after-hours fun too, this affordable oxford from Zengara features standup-stitched seams and a narrow bicycle toe that'll instantly update anything you pair with it. Insole padding and a rubber-enforced block heel assure a comfortable, confident step.
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Zengara Men's Z30169 Oxford
Casual Lace-Ups item created by admin, Jul 13, 2011
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Bird 16" x 20"
Bird 16" x 20"
480.00 960.00
Inspiration for The Bird was to create organic, flowing elements and patterns merging together.
This is a mixed media drawing. All detail is achieved by hand. For this piece I used gel impact paint pens, glitter glue, liquid gilding, beads on art board.
I ship only within the United States for now. Please note shipping is not calculated in the price.
Add To Cart


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House prices in New Ridley Road, Stocksfield NE43
What is the current average value of properties in New Ridley Road?
The current average value in New Ridley Road in May 2017 is £325,598. This has increased 1.68% from February 2017. Terraced properties sold for a current average value of £164,650 and semi-detached properties valued £272,830. In the past year property prices in New Ridley Road have increased 3.29%. This is according to the current Zoopla estimates.
You could be overpaying for energy in New Ridley Road, Stocksfield NE43
Yearly saving up to:
Detached house
Semi-detached house
End terrace house
- Compare energy deals
Data on sold house prices, such as the results above for New Ridley Road Stocksfield NE43, is supplied to us via monthly updates from the Land Registry for England and Wales and from the Registers of Scotland for Scotland. There may be a delay of up to 3 months from when a property is actually sold to when it becomes officially recorded with Land Registry and/or Registers of Scotland. We provide data on house prices for information only, on an 'as is' basis as supplied to us and accept no liability for any errors or omissions. If you have identified any incorrect information in, please Report an error.


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Bulls' Rajon Rondo fined $25,000 for attempting to trip Celtics' Jae Crowder in Game 3
Bulls' Rajon Rondo fined $25,000 for attempting to trip Celtics' Jae Crowder in Game 3
Rajon Rondo's emergence made sure the Bulls played on the edge but one always had to wonder where he would go over the line—an aspect Jae Crowder and the NBA figured out Friday night.
Rondo was fined $25,000 by the NBA for sticking his leg out in an apparent attempt to trip Crowder when Crowder was close to the Bulls' bench late in the first quarter of Game 3 Friday night.
[BULLS TICKETS: Get your seats right here]
Television replays caught Rondo's leg extending after Crowder hit a 3-pointer right in front of the Bulls' bench.
Rajon Rondo is sidelined with a thumb injury, but his legs seem to be working fine 🤔 pic.twitter.com/RLukiBAFuC— Bleacher Report (@BleacherReport) April 22, 2017
When asked Rondo claimed that due to an ACL surgery he had several years ago he had to extend his leg to keep it from getting stiff.
"When you tear an ACL your leg gets stiff on you. I always do that," Rondo said. "He may have been so deep on our bench."
Upon investigation from the NBA, it issued Rondo a stiff fine and the increasingly contentious series will take another turn Sunday evening in Game 4.
Rondo is expected to miss the rest of the series with a broken right thumb after being a key to the Bulls taking a 2-0 lead by stealing two wins in Boston last week, averaging a near triple-double.
Morning Update: Bulls prep for Game 4; Cubs won; Sox lost
Morning Update: Bulls prep for Game 4; Cubs won; Sox lost
Here are some of Saturday's top stories in Chicago sports:
Five Things to Watch: Bulls battle Celtics in Game 4 today on CSN
Preview: Cubs look to sweep Reds on CSN
White Sox scoreless streak hits 23 innings in loss to Indians
No clear options for Fred Hoiberg at point guard
Two days later, Blackhawks still stunned, 'embarrassed' by quick exit
Cubs offense explodes with three home runs in victory over Reds
Stan Bowman 'completely, completely disappointed' with Blackhawks
White Sox prospect Carson Fulmer: 'Our time is coming soon'
Still in mourning, Isaiah Thomas dictates pace, delivers for Celtics


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You can create your account today through Sunday, June 4, 2017 at 15:00, MST.
Judges and stewards may register now through Saturday, June 3, 2017 at 15:00, MST.
You can add your entries to the system today through Sunday, June 4, 2017 at 14:00, MST.
$0.00 (USD) per entry.
If a sub-category's name is hyperlinked, it has specific entry requirements. Click or tap on the name to view the sub-category's requirements..
|1D American Wheat Beer
|10A Weissbier
|10B Dunkels Weissbier
|10C Weizenbock
|24A Witbier
Each entrant is limited to 3 entries for this competition.
Each entrant is limited to 1 entry per sub-category .
After creating your account and adding your entries to the system, you must pay your entry fee(s). Accepted payment methods are:
1 bottle per entry, brown glass 12oz or 22oz bottle, no commercial labels.
Entry bottles accepted at our drop-off locations from Monday, March 27, 2017 at 08:00, MST through Sunday, June 4, 2017 at 15:00, MST.
Confident Brewer
260A W Fry Blvd Sierra Vista, Arizona
(520) 508-2863
*Ensure you have your entries labeled
Tombstone Brewing Company
107 E Toughnut St, Tombstone, AZ 85638
Sunday, June 11, 2017 at 15:00, MST
The Homebrew of the Year (HBY) award. How the scoring will work:
Each entry into the Club Only Competition earns the brewer a point, additionally, first place earns six points, second place earns four points and third earns two points. In head-to-head competitions (two competitions in one with a BOS), the BOS winner receives an additional six points. The brewer with the most points after the four competition will earn the coveted title of Buffalo Club Homebrew of the Year!
Each entry (up to 3): +1
First Place: +6
Second Place: +4
Third Place: +2
Best of Show (BOS): +6
The Buffalo Club Homebrewer of the Year is awarded annually at the New Year Buffalo Club Meeting in January.
Tombstone Brewing Company
107 E Toughnut St, Tombstone, AZ 85638
Sunday, July 9, 2017 at 15:00, MST


text:
- Few Southeast students face suspension, expulsion for sexual assaults, campus paper finds (4/25/17)6
- Perryville family organizing bone-marrow drive Friday for ailing 6-year-old boy (4/26/17)
- Woman battered after smashing boyfriend's meth pipe against wall, police say (4/25/17)1
- Temptations bassist dies after Cape Girardeau show (4/26/17)2
- Event includes the first public tour of 200-year-old Elmwood Manor (4/23/17)3
- BBB warns Jackson man's online business might not be legit (4/24/17)
- Pilot House goes smoke-free (4/23/17)10
- State Supreme Court rules against congressman's mother in dog-kennel defamation case (4/27/17)1
- Strattman to step down as principal at St. Mary (4/28/17)1
- Cape couple turns their home into cozy, comfortable music venue (4/24/17)
Red Cross deserves strong support
Southeast Missouri residents are to be applauded for their unwavering support of the American Red Cross after the terrorist attacks of Sept. 11.
The donations have been nothing short of amazing.
In some area parking lots, nearly every third car bears one or more patriotic, magnetic bumper sticker. Each of those represents at least a $2 donation to the Red Cross. Magna-Tel Inc. of Cape Girardeau provided them initially for free and then at cost, and most notably KFVS and other businesses sold them to the public.
The Cape Girardeau-based television station received the Missouri Good Neighbor Award from the Missouri State Service Council of the American Red Cross, which honored the station for creating and sponsoring the annual Heartland Blood Drive and raising $100,000 through the flag-magnet campaign.
The Red Cross raised more than $200,000 total from sales of the magnets. As requested by Magna-Tel's Mary Ann Farmer, half the money will be used locally and the other half donated to the Liberty Fund to aid victims of the Sept. 11 attacks.
And then there are the T-shirts bearing the heartwarming "God Bless America" slogan. Thousands of dollars were raised by groups offering these to the public and by donors happily grabbing them up.
But now some in the local organization are understandably concerned by national news coverage.
The national Red Cross president, Bernadine Healy, was criticized for setting up a separate account for Liberty Fund donations -- money that many donors thought was going only to victims of Sept. 11 terrorist attacks. The organization had intended to put some back for possible attacks in the future.
And while that course of action has been corrected -- and Healy has since stepped down, it left some concerned about the organizations' trustworthiness.
A distinction absolutely must be made between the national organization and our local chapter here in Cape Girardeau.
Executive director Mary Burton and her band of volunteers are vital to disaster relief in 18 Southeast Missouri counties. Far from the terrorist attacks on the East Coast, they help area residents every day. If there's a fire, they're on the scene. If there's a natural disaster, they arrive with food and blankets. If a U.S. Navy sailor needs to receive news from home, the Red Cross contacts him or her with that information.
They are the ones who see to it that there is enough blood on the shelves to help that accident victim or that baby who needs surgery.
Nothing should deter us from our usual donations to the Red Cross this year. They are as important now -- or maybe more important -- as ever.


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The Riddle of the Third Mile
Cover of the first edition
|Colin Dexter
|Cover artist
|Chris Brown
|United Kingdom
|Inspector Morse series, #6
|crime novel
Publication date
|27 October 1983
|Media type
|Print (Hardcover)
|Preceded by
|The Dead of Jericho
|Followed by
|The Secret of Annexe 3
The Riddle of the Third Mile is a crime novel by Colin Dexter, the sixth novel in Inspector Morse series.
Inspector Morse is not sure what to make of the truncated body found dumped in the Oxford Canal, but he suspects it may be all that's left of an elderly Oxford don last seen boarding the London train several days before. Whatever the truth, the inspector knows it will not be simple—it never is. As he retraces Professor Browne-Smith's route through a London netherworld of topless bars and fancy bordellos, his forebodings are fulfilled. The evidence mounts; so do the bodies. So Morse downs another pint, unleashes his pit bull instincts, and solves a mystery that defies all logic.
Publication history[edit]
- 1983, London: Macmillan ISBN 0-333-35812-0, Pub date 27 October 1983, Hardback
- 1984, New York: St. Martin's Press ISBN 0-312-68228-X, Pub date February 1984, Hardback
Plot summary[edit]
The novel is divided into three books - the first mile, the second mile and the third mile. The title is a reference to the biblical sentence "And whosoever shall compel thee to go a mile, go with him twain" as in St Matthew, Chapter Five, Verse Forty-One. The third mile could also indirectly refer to a particularly elaborate scheme used in the book to lure three of the college staff to London.
The First mile[edit]
There are three main narratives in this book.
During the Second World War, there are three brothers Albert, Alfred and John Gilbert serving as tank drivers in the army. Albert and Alfred are said to be look-alike twins. The youngest brother is trapped in his tank during an offensive and is burnt to death. The two elder brothers are unable to help due to a direct order from the lieutenant Browne-Smith. They develop a hatred towards Browne-Smith (mistakenly) believing that his cowardice caused their brother's death.
At the present time, Browne-Smith is a Professor at Oxford. He departs on a mysterious trip to London where he visit a topless bar and then proceeds to a brothel. There he is served drugged drinks and collapses on the bed.
A few days later, the Master of Lonsdale College invites Morse to lunch and voices suspicion about the disappearance of Browne-Smith. He has left the college without any communication or forwarding address. Morse promises to keep an eye out for any information that comes his way. It is revealed that Morse was a student of Browne-Smith in his college days and the reason Morse picked up his obsession for grammar and spelling. We also see a short flashback into Morse's days in Oxford and his breakup with his lover.
Then, the police discover a dismembered corpse in the water at Thrupp. The corpse is missing the head, arms and legs. This makes identification difficult, but Morse believes that the corpse could be that of Browne-Smith. It is also found that Browne-Smith was suffering from a brain tumour and had only a few more weeks left to live.
The Second Mile[edit]
As more evidence accumulates, suspicion seems to fall on the Don Westerby who was antagonistic towards Browne-Smith at Lonsdale College and is supposedly on a holiday in Greece after his recent retirement. But Morse speculates that the body is not that of Browne-Smith but probably Westerby, thereby the need to dismember the corpse to confuse the police.
During a visit to Browne-Smith's room at the college, Morse meets one of the Gilbert twins who is running a packers and movers business engaged to shift the retired Westerby's effects. Morse gains the address of Westerby's new flat in London from the Gilbert twin. On travelling there, he finds another corpse, this time stabbed with a screwdriver. In a moment of forgiveable lapse brought about his fear of corpses, Morse does not recognise the murderer and allows him to walk free.
The second mile concludes with three more deaths - one being murder, one suicide and one natural causes, leaving none of the suspects alive.
The Third Mile[edit]
Morse largely guesses how things happened. His theory goes as follows: the Gilbert twins wanted to kill Browne-Smith in order to avenge the death of Johnny Gilbert and set up an elaborate scheme to lure him to London. They realise that Johnny actually committed suicide so let Browne-Smith go. Browne-Smith, in turn, uses the same scheme to lure Westerby and confronts him before realising that he was mistaken in his antagonism. He has always assumed (wrongly) that Westerby had voted against him in the election for Master of the college. Westerby and Browne-Smith both realise that the current Master had voted against both of them in their previous elections. So they use the same scheme for the third time to lure the Master to London and kill him. Browne-Smith was, however, guilt-ridden and tried to steer Morse to the culprits. It is suggested that he was mentally not in control due to side-effects of the tumour.
Morse further guesses that the corpse found in Trupp was that of the Master. Westerby killed Alfred in his London flat and in turn, Albert killed Westerby and then committed suicide. Browne-Smith died of his tumour.
- Albert Gilbert
He is one of the Gilbert twins. He is described as the quick witted and resourceful of the two. He kills Westerby and commits suicide on learning that his wife has left him.
- Alfred Gilbert
He is the second twin and is killed by Westerby.
- Professor Browne-Smith
He is a don in Lonsdale College and suffering from a life-threatening brain tumour. He was a former Lieutenant and the Gilbert brothers served under him. Like Morse, he is obsessed with grammar and spelling.
- Professor Westerby
Another professor at Lonsdale who dislikes Browne-Smith as he thinks that Smith voted against him in the election for the Master's seat. He used his car to dump the first corpse into the river at Trupp.
- Master of Lonsdale
While never mentioned by name, he is finally revealed to be of a dubious character. He voted against Smith and later Westerby thereby voting them out of the race for the Mastership. He is also said to be involved in inappropriate dealings about examination results.
Sources, references, external links[edit]
- Bishop, David, The Complete Inspector Morse: From the Original Novels to the TV Series London: Reynolds & Hearn (2006) ISBN 1-905287-13-5
- Bird, Christopher, The World of Inspector Morse: A Complete A-Z Reference for the Morse Enthusiast Foreword by Colin Dexter, London: Boxtree (1998) ISBN 0-7522-2117-5


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Arts and crafts period table lamp in copper
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Stay connected with us to get the latest health and fitness news, innovative workouts, healthy recipes and wellness tips.
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Use a combination of these core back exercises to strengthen your lower, upper or middle back areas. Whether you're interested in barbell deadlifts or reverse extensions, we have back strengthening exercises for every level. These exercises are also featured in convenient workout routines that include proper warm-up and cool-down techniques, which greatly reduces the risk of injury.
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With so much conflicting information out there, it can be a challenge to separate fact from fiction when it comes to reducing fat and losing weight. ACE Pro Brett Klika examines three particularly common and pervasive myths that everyone needs to stop believing now.
Adopting a new healthy habit, however big or small, comes down to one thing: consistent action. To increase your chances of success when adopting a new habit, here are six steps that will help simplify the process and keep you on track.
March Madness is almost here—an exciting time for basketball fans. But for those who are playing basketball in adult leagues year-round, improving your skills and staying healthy is not limited to one month a year. Incorporating these exercises, which focus on fitness...


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Today's Photo of the Day was posted by Alice Tiara and shows who I think is a young child (maybe Alice?) playing on the greatest gift a young kid could get in the 1970s and 1980s, a Commodore PET. Since this is how many kids from that generation were introduced to computers, this should be have been the photo they used in the ad for the PET.
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The Retroist is like a BBQ on a bun without the bones. You're only human daddy. Chomp!
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- This 1979 TV Guide Fall Preview Guide commercial is spectacular - April 26, 2017
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이 아이디어와 더 많은 아이디어를 탐색하세요!
엔드 이미지
Smile real big !
New Dog Breed: The Meth Lab.... I laughed way way too much!
Toy & Jiji are father and son. What little cuties! They live together with Jiji's mum Kiki.
Country, Shabby & Rustic ... "See bottom of page"
... poetry pic picture photo image friendship famous quotations proverbs
Omg! Cutest kitten ever!
Ohmygosh don't even pretend to tell me this isn't the cutest thing you've ever seen.
from Inviting Home
I saw this and needed to repost it. These are NOT miniature donkeys. These are goats and by the photos they are pygmy goats. Although they are cute there is a clear difference between a goat and a donkeys
This adorable photo of a puppy wearing a hat way too big for him is beautiful.
That's what friends are for..hahahahaha
After a long week of working on my credentialing...I sure am thankful it is Friday :)
WANT ONE SOOOOO BAD!!! <3 <3 <3 <3 Those eyes, those spots... THE DOG!! :')
Um dos bichinhos mais fofos que existe. Como alguém pode matá-los e comê-los?


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Partnership Sales Executive, Food Portfolio
A fantastic opportunity to work in one of the largest and most creative Media Partnerships teams in the UK. They are well established and awards wi...
Talented and Intuitive Qualitative Researchers
One of the most insightful Qualitative agencies, with offices on 3 continents, is looking for sharp and driven Qualitative Researchers looking for ...
PR - Senior Account Executive - Food & Drinks
PR - Senior Account Executive - Food & DrinksCompany: AgencySalary: Flexible basic, + the added bitsLocation: LondonFocus: Consumer; Luxury and Pre...
Senior Sales Executive - Content Marketing Agency
Our client is a leading content innovation agency which creates end-to-end content ecosystems that fuel customer engagement and loyalty. They are l...
Motion Graphics Designer - Unilever
OLIVER are looking for a Motion Graphics Designer, in Rotterdam to work with one of our biggest clients, Unilever, on the Food Solutions category.
Motion Graphics Designer - Unilever
OLIVER are looking for a Motion Graphics Designer to work on-site with one of our biggest clients, Unilever, on the Refreshments brand category.
Digital Designer - Unilever
OLIVER are looking for a Digital Designer to work with one of our biggest clients, Unilever in Rotterdam, looking after the Food Solutions category.
Business Development Manager
Selling creative media solutions on both print and digital offering at this leading content management company on their flagship account.
Mid-Weight Designer
THE OPPORTUNITYAmazing, fast growing design and branding agency in BirminghamWork with high profile national and global FMCG clientsOpportunity to ...
Interim Customer Marketing Executive
My world renowned FMCG client is looking for a Customer Marketing Executive to execute and implement travel retail activations. Ideally you will ha...
International Sales Executive
International Sales Executive, £35K +30% Commission We are looking for a confident and engaging individual to join our team in planning, selling ...
Senior Consumer Branding Designer
An award - winning Brand design agency is looking for a Senior Consumer Branding Designer to join their team! This is a rare opportunity to work fo...


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Branding music
Portband Identity & Platoform by Donhkoland
Full website experience design for a music producing and event organizing company ( throtl_ ) Elegant typography and a detailed color palette with some very subtle photography was the way to transfer events energy to the visiting crowd.
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Co-Branded Music Campaigns : respect the craft
"Ocean Drive" Duke Dumont) Guitar–Sergey Putyatov) Brand music–2017)
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Music Flower Brand Black Waterproof Eyeliner Gel Makeup Cosmetic Gel Eye Liner With Brush 24 Hours Long-lasting For Women
KALA Brand Music Company - Where Innovation meets Tradition, Passion meets Playability, & Quality meets Value. Check out our beautiful ukulele and U-Basses and more.


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text: Home / Community Life Browse Brightview News Kim O'Connell, Wellspring Village Director, Honored with Coach of the Year – Caregiver Inspiring Artwork Inspires Others Joan's face lit up when she saw the T-shirts bearing her design - a beautifully painted butterfly in pink and purples hues. Making the Most of Each Day "The good feeling I get from being with other people is most important to me," explains Carole. Residents Partner with North Andover Garden Club to Create Beautiful Flower Arrangements Wellspring Village® residents partner with volunteers from North Andover's Garden Club to create stunning flower arrangements and spread joy throughout the community. Resident Discovers Passion for Painting When Ethel moved to Brightview North Andover, she discovered a hidden talent: a passion for painting. News from The Boston Globe: Greater Boston's Lost Ski Areas Evoke Fond Memories Small ski areas are like individual snowflakes. No two are alike. They can be beautiful, sometimes more so when viewed through the prism of our memories. News from The Eagle Tribune: Brightview Celebrates First Year in North Andover For many years, Boston Hill was a popular skiing venue. Today it fulfills a different mission. Browse News Latest News 2017 2015 2014 Brightview Tenafly Associate Awarded Prestigious Prize April 27, 2017 We Believe... April 24, 2017 Brightview Warren Celebrates Grand Opening April 20, 2017 Brightview Lake Tappan Under Construction April 20, 2017 Vibrant Living Director Jessica Davis is Eversounds Champion of the Month March 22, 2017 104 Years Young; Happy Birthday, Mary March 07, 2017 Spirit of Generosity Thrives at Brightview Commons March 07, 2017 Executive Director at New Pond Village Honored with Distinguished Assisted Living Administrator Award February 21, 2017 A Gift With Words January 31, 2017 SPICE in Motion A Fun and Engaging Exercise Program January 26, 2017 Back to Top Print


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pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials
PubMed | Breast Unit, Rotkreuzklinikum Munich, University of Cologne, Schwanebecker Chaussee and 4 more.
Type: | Journal: Breast (Edinburgh, Scotland) | Year: 2017
Patients with bilateral breast cancer (BBC) are usually excluded from participating in clinical trials and little is known about the response and outcome of BBC to neoadjuvant chemotherapy compared to unilateral BC (UBC).We prospectively captured the information on patients with BBC in our database treated within four neoadjuvant chemotherapy trials and collected retrospectively the rate of pathological complete response (pCR) defined as ypT0 ypN0, ypT0/is ypN0, ypT0 ypNX, clinical and histologic parameters. Synchronous carcinoma in the contralateral breast was considered as the non-indicator lesion. Patients with UBC only treated within the same neoadjuvant trials performed the control group.From the 6727 patients treated within 4 German neoadjuvant trials 119 (1.8%) patients have been identified with the diagnosis of BBC. The pCR rate (ypT0 ypN0) was 12.6% in the non-indicator lesion group versus 10.9% the indicator lesion group versus 20.9% for patients with unilateral disease (p=0.003). There were more advanced tumor stages and positive axillary lymph nodes in the indicator lesion than in the nonindicator lesion or in UBC. In 52.5% the molecular subtype was identical between indicator and non-indicator lesion with more triple negative and HER2 positive BC in the group of UBC. The disease free survival rate (DFS) was 25.8% for patients with UBC versus 39.6% for patients with BBC.The selection for the indicator lesion was based on tumor size, nodal status and inclusion criteria. Patients with BBC patients had a lower pCR rate and a lower DFS.
Varga D.,Universitatsfrauenklinik Ulm |
Wischnewsky M.,University of Bremen |
Atassi Z.,Universitatsfrauenklinik Ulm |
Wolters R.,University of Bremen |
And 4 more authors.
Oncology | Year: 2010
Background and Objective: Guidelines for the treatment of early-onset breast cancer have been proposed in several countries, but to date, their impact on outcomes is unverified. The objective of this study was to evaluate the association between guideline-adherent versus nonadherent treatment and recurrence-free survival (RFS) and overall survival (OAS) in early-onset breast cancer patients. Methods: A total of 1,778 patients were included in the study, of whom 111 were 35 years or younger and 1,667 were between 36 and 55 years. RFS and OAS were compared between the two groups, with respect to multiple parameters. All survival data were adjusted for tumor characteristics and analyzed with respect to guideline adherence according to the German Step 3 guidelines. Results: Statistically significant differences between the two groups (<35 years, 36-55 years) were observed with regard to breast surgery (p = 0.002) and hormone therapy (p = 0.006). Both groups were treated identically in terms of guideline adherence concerning axillary dissection (p = 0.9), radiation therapy (p = 0.7) and chemotherapy (p = 0.556). Young breast cancer patients whose treatment adhered to guideline recommendations had increased RFS and OAS [RFS: p = 0.030, hazard ratio (HR) 2.95, 95% confidence interval (CI) 1.11-7.83; OAS: p ≤ 0.001, HR 2.92, 95% CI 2.01-4.23]. Conclusion: Guideline-adherent treatment for early-onset breast cancer patients significantly improves OAS and RFS and should therefore be demanded for all patients. © 2010 S. Karger AG, Basel.
Effects of guideline-compliant therapy on the survival of primary breast cancer patients with: Results of a retrospective cohort study [Auswirkungen leitlinienkonformer Therapie auf das Überleben von Patientinnen mit primärem Mammakarzinom - Ergebnisse einer retrospektiven Kohortenstudie]
Wolters R.,University of Bremen |
Wockel A.,Universitatsfrauenklinik Ulm |
Wischnewsky M.,University of Bremen |
Kreienberg R.,Universitatsfrauenklinik Ulm
Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen | Year: 2011
Purpose: The development and implementation of the "Interdisciplinary S3 Guideline for the Diagnosis, Treatment and Follow-up Care of Breast Cancer" (3) is intended to optimise national health services. This guideline already serves both as a basis for the certification of German breast centres and for the external comparative quality assurance based on guideline based quality indicators. Nevertheless, the effects of the implementation on relevant outcomes have not been examined so far. Methods: The retrospective cohort study analyses data of 3,976 female patients with primary breast cancer which were collected at the University of Ulm and co-operating certified breast centres between 2001 and 2005. Based on the S3 guideline, an analysis model was developed to allow for the examination of guideline-adherent therapy on the basis of the guideline recommendations, and the effects of guideline-adherent compared to not guideline-adherent therapy on overall (OAS) and recurrence-free survival (RFS) were examined subsequently. Results: In total, 2,063 (51.9%) of the 3,976 patients were treated in adherence the guideline. In 1,913 (48.1%) patients deviations from the guideline recommendations in at least one of the therapeutic options were found. The variable "guideline-adherent treatment" had significant influence on RFS [p < 0.001; HR = 2.20; 95% CI (1.74 to 2.79)] and OAS (p < 0.001; HR = 2.57; 95% CI (1.96 to 3.37)], each adjusted for age, tumour size, nodal status and grading. RFS decreases with the number of deviations from guideline recommendations [1 to 2 deviations: p < 0.001; HR = 2.04; 95% CI (1.60 to 2.60); ≥ 3 deviations: p < 0.001; HR = 3.64; 95% CI (2.43 to 5.45), also adjusted for age, tumour size, nodal status and grading]. Similar results were found for the OAS. Conclusion: Patients with breast cancer should be treated in adherence to guideline recommendations. Deviations and barrier factors will have to be evaluated in the future in order to further optimise both the guideline and guideline-adherent therapy.
CA2729 as a tumour marker for risk evaluation and therapy monitoring in primary breast cancer patients
PubMed | estimate GmbH, Frauenklinik des Universitaetsklinikums Charite Campus Virchow Klinikum, Universitatsfrauenklinik Ulm, University of Heidelberg and 4 more.
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2016
Several trials showed that tumour markers are associated with an impaired prognosis for breast cancer. Whether earlier treatment can improve the course of the disease remains controversial. The SUCCESS Trial compares FEC (500/100/500)-docetaxel (100) vs. FEC (500/100/500)-docetaxel/gemcitabine (75/2000) as well as 2 vs. 5years of zoledronate in high-risk primary breast cancer patients. In 2669 patients, CA27.29 was measured before and after chemotherapy with the ST AIA-PACK CA27.29 reagent for the AIA-600II automated enzyme immunoassay (Tosoh Bioscience, Belgium). Values above 31U/ml were considered positive. Of the patients, 7.6% (n=202, mean 19, range 3-410) and 19.1% (n=511, mean 21, range 3-331) had elevated marker levels before and after chemotherapy, respectively. Of the patients, 4.9 and 78% showed elevated and low CA27.29, respectively, at both time points. After treatment, 35% of the pre-therapy positive patients were negative, and 15% of the initially negative patients became positive. The correlation between both time points was significant (p<0.0001). No correlations among nodal status, grading, hormonal status, HER2 status and CA27.29 levels were found. However, tumour size (p=0.02), older age (p<0.001) and post-menopausal status (p=0.006) were significantly associated with higher CA27.29 levels. Before treatment, the prevalence of elevated CA27.29 was equally distributed between both treatment arms, whereas after chemotherapy, 13.7% of the patients in the FEC-doc arm showed an increased level vs. 25.4% of the patients in the FEC-doc/gemcitabine arm (p<0.0001). However, we could not show a significant association between the G-CSF application (yes vs. no) and CA27.29 status before/after chemotherapy (p=0.75). These results indicate a close relationship between CA27.29 levels and tumour mass. Increased values after the completion of chemotherapy might be attributed to treatment effects and should be considered with caution.
Vulvar cancer. Possibilities of reconstructive surgery [Vulvakarzinom: Möglichkeiten der sicheren, rekonstruktiven chirurgie]
Hampl M.,Heinrich Heine University Düsseldorf |
Janni W.,Universitatsfrauenklinik Ulm
Gynakologe | Year: 2012
Whereas decades ago, vulvar cancer was a tumor primarily diagnosed in older women, nowadays, this tumor is increasingly seen in younger women. The rising incidence is mainly due to the increasing number of young women presenting with these tumors. Depending on the age of the women, persistent infection with high-risk human papillomavirus is responsible for the development of these lesions in 30-50% of the cases. More than 50% (our own data) of the tumors are located between the clitoris and urethra. Standard treatment is tumor resection with sufficient margin or (partial) vulvectomy and complete inguinofemoral lymphadenectomy or sentinel node biopsy in specialized centers. New therapy options include reconstruction of the vulva with local skin flaps to improve esthetic and functional outcome especially in young, sexually active women. © Springer-Verlag Berlin Heidelberg 2012.
Distinct expression of cytokeratin, N-cadherin and CD133 in circulating tumor cells of metastatic breast cancer patients
Bock C.,Ludwig Maximilians University of Munich |
Rack B.,Ludwig Maximilians University of Munich |
Huober J.,Universitatsfrauenklinik Ulm |
Andergassen U.,Ludwig Maximilians University of Munich |
And 2 more authors.
Future Oncology | Year: 2014
Aim: Circulating tumor cells (CTCs) appear as potential candidates to predict the ability of breast tumors to metastasize. Moreover, epithelial-mesenchymal transition (EMT) and stem cell features are major mechanisms for metastasis. Patients & methods: Using a triple fluorescence technique, the expression of EMT (N-cadherin) and stem cell markers (CD133) was analyzed in CTCs detected via cytokeratin in blood samples from 26 metastatic breast cancer patients. Results: We detected CTCs in 100% of the patients (n = 831 CTCs). In total, 67% of the CTCs were N-cadherin and CD133 negative. Nonetheless, 87.8 and 57.6%, respectively, of the CTCs that expressed one marker coexpressed the other. Both double-negative and double-positive CTCs were present in more than 90% of the patients. Within the CTCs of each patient, we demonstrated striking heterogeneities of marker expressions, cell shapes, clusters and sizes. Conclusion: These data outline the importance of characterizing CTCs, especially through stem cell and EMT markers. © 2014 Future Medicine Ltd.
Pediatric and adolescent gynecology : Basic knowledge for gynecological practice [Kinder- und Jugendgynäkologie : Basiswissen für die Frauenarztpraxis]
Buck G.,Universitatsfrauenklinik Ulm |
Kreienberg R.,Universitatsfrauenklinik Ulm
Gynakologe | Year: 2010
The subspecialty of pediatric and adolescent gynecology has long been an integral part of gynecological practice and cooperation with pediatricians, pediatric surgeons, pediatric urologists, and psychologists is also well established. To an increasing extent adolescents are posing their gynecological questions directly to gynecologists. This requires particular dedication in dealing with young patients and naturally expert knowledge of the disorders and diseases typical for this phase in the adolescent's life. In view of the dismal increase in teen pregnancies and abortions, attention paid to this age group has been intensified in recent years. Irregardless of whether special consultation services for pediatric and adolescent gynecology or girl/teen consultation sessions are offered, this enormous chance should be seized to address prophylaxis regarding contraception, infections, and lifestyle questions such as nutrition, smoking, and sports. © 2010 Springer-Verlag.
Bekes I.,Universitatsfrauenklinik Ulm
Gynakologe | Year: 2014
A 21-year-old primipara at 30+3 weeks of gestation presented with symptoms of acute pancreatitis. Since she additionally complained of dyspnea, chest X-ray and computed tomography examinations were performed. A left-sided enterothorax was seen with stomach and bowel dislocation. Owing to the high maternal and fetal risk, an emergency laparotomy was carried out in which a congenital diaphragmatic defect in the left trigonum lumbocostale (Bochdalek hernia) was found. In addition to a cesarean section, relocation of the stomach and colon was performed with closure of the diaphragmatic defect. © Springer-Verlag 2014.
The role of preoperative ultrasound evaluation of inguinal lymph nodes in patients with vulvar malignancy
De Gregorio N.,Universitatsfrauenklinik Ulm |
Ebner F.,Universitatsfrauenklinik Ulm |
Schwentner L.,Universitatsfrauenklinik Ulm |
Friedl T.W.P.,Universitatsfrauenklinik Ulm |
And 5 more authors.
Gynecologic Oncology | Year: 2013
Objectives. Inguinal lymphadenectomy in vulvar malignancies is associated with significant morbidity, especially in patients over 70 years old. Under certain conditions, surgical guidelines recommend biopsy and evaluation of the sentinel node in early vulvar cancer. The purpose of our study is to evaluate ultrasonography as a predictor of inguinal lymph node involvement. Methods. A retrospective study was performed with 60 patients who had vulvarmalignancies (92% of which were squamous cell carcinomas) and who were treated at our hospital between 2002 and 2012. The patients ranged in age from 35 to 89 years, with a median age of 76 years. In total, 118 groin scans were retrospectively evaluated for sonographic evidence of lymph node involvement (i.e., absence of fatty hilum, irregular shape, cortical region diameter and vascularization pattern). The results were then compared with histopathologically confirmed lymph node status. Results. Histopathologically confirmed lymph node status was available for 107 of the inguinal nodes examined by ultrasound, and lymph node metastases were found in 38 (35.5%) cases. The presence or absence of inguinal lymph node metastases was correctly identified by sonography in 92 (86.0%) of the scanned areas. Sensitivity was 76.3%, specificity was 91.3%, and positive and negative predictive values were 82.9% and 87.5%, respectively. Conclusions. Ultrasonography of the inguinal lymph nodes showed a relatively high sensitivity and specificity for predicting inguinal tumor metastases. However, our results indicate that surgical lymph node staging is still needed to precisely determine inguinal lymph node status in vulvar cancer, especially because a missed lymph node-metastasis is often fatal. © 2013 Elsevier Inc. All rights reserved.
Abdominal hysterectomy: Obsolete or experiencing a forensic renaissance? [Abdominale Hysterektomie: Obsoleter Dinosaurier oder forensische Renaissance?]
de Gregorio N.,Universitatsfrauenklinik Ulm |
Ebner F.,Universitatsfrauenklinik Ulm
Gynakologe | Year: 2016
In the last decade a trend from abdominal access for hysterectomy to a laparoscopic approach could be observed. This article deals "close minded" with the abdominal (AHE) vs. laparoscopic hysterectomy in form of a classic pro-con discussion. To get this straight: The authors dislike the grim discussion about surgical techniques. There are several hysterectomy variations of which each one has benefits and disadvantages. Also this article should not present a detailed list of complications (i. e. LAVH has more urogenital injuries, secondary wound healing is more common with AHE, …), but should provide a general reasoning for the surgical indication. The authors agree that the correct technique is the one the surgeon feels comfortable with and the patient is satisfied. © 2016 Springer-Verlag Berlin Heidelberg


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Juneau Assembly dives back into the AJ Mine issue tonight (Monday).
Members have had more than a month to review a draft study of the city's water system, compiled by Engineering Director Rorie Watt. At tonight's Committee of the Whole meeting, Watt says he'll be seeking direction on what to do next.
"The Assembly has asked for this investigation," Watt says. "And we'll find out if they feel like it answers their questions, or if they need more information about water, or if they want to continue to consider mine development, or if they want to debate the topic. I'm not going to predict what they're ready to do."
Over the past year, the Assembly has been considering whether to pursue re-opening the old AJ Mine near downtown. The city owns part of the ore body, located in Last Chance Basin – Juneau's main water supply.
A mine advisory task force last year urged the Assembly to request the water study. The draft report gives an overview of city's water system, and identifies several scenarios and management concepts, with and without a gold mine operating nearby. The scenarios range from no action to leasing the AJ property to a mining company.
Watt has been gathering public input on the draft study. He says most people have had questions about the city's water system, though a few categorically oppose mine development. Some of the written comments are included in the latest version of the study.
Watt says ultimately the Assembly will need to decide if the drinking water issue is a fatal flaw to any proposal to re-open the mine.
"That's, at a policy level, what they need to decide," says Watt. "And then once they are comfortable in having enough information to make that decision, we'll see what happens."
The Assembly last year appropriated $250,000 dollars for the water study. So far, Watt says $68,000 has been spent – about $33,000 to consultants Juneau Watershed Partnership, TetraTech and Carson Dorn. The rest has been spent on CBJ Engineering staff time.
Watt says he hasn't made any major changes to the draft report, since bringing it to the Assembly at the end of February. At members' request, he did add a better explanation of water flow rates to a technical section of the report.
Tonight's Committee of the Whole meeting starts at 6 p.m. in Assembly chambers.
AJ Mine Water Study Draft Report
Water study public comments [PDF]
Recent headlines
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Southeast Alaskans predict tariff's effects on timber marketAccording to a U.S. Commerce Department report, Canadian exports of softwood lumber to the United States in 2016 were valued at $5.6 billion.
Ancient speartip leads to recognition for Round IslandPrior to the discovery of the spear-tip, it was thought that human habitation on the islands dated back only 2,500 years.
Time to consult Congress over use of force against ISIS, lawmakers sayThe U.S. has relied on legislation from 2001 to justify its use of force against ISIS. But a bipartisan group of representatives say it's outdated, and argue it's time for a debate.


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