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Hooray for another Friday! Today we wanted to spread some positivity with the help of artist Jenna Kutcher. We love her typography style & her floral, watercolour design work! Not only is this print lovely to look at, it also encourages us all to follow our dreams & to never quit! We think that's a great motto to live by & wanted to share it with our lovely readers.
Be sure to check out Jenna's other prints & products via the link above! She's an advocate for positivity, just like us in the RT studio!
Stay positive everyone & have a wonderful weekend!
Posted by: Holly]]>
Welcome back to another Interiors Roundup blog post! Today we've got some fabulous inspiration in store for any furniture lovers out there!
As our readers will know, we always keep an eye out for unique interior touches with tons of personality. That's why we were so thrilled to come across La ZUZE Upholstery on Etsy! LZU is a Manchester-based shop that sells upcycled furniture (specifically chairs & stools), often in gorgeous, bright patterns & colours!
The first item in the La Zuze shop that caught our eye was their Queen Anne Wingback Chair (pictured below) & from there we were in love! We can imagine these bold prints & patterns in a super stylish home.
La ZUZE describes their shop as "[A] passion and love for upholstery put in exclusive one-off pieces of furniture to bring the fresh and quirky vibes into your home." With such a creative & vibrant shop motto, it's no wonder we adore their creations so much! Commenting on the history of their wonderful shop, LZU say, "'La ZUZE Upholstery' was born from the love of learning and exploring the new and unknown. With the almost accidental turn of learning how to create a footstool in an uphostery class, the newly discovered hobby was born.
The furniture presented here on 'La ZUZE Upholstery' is nowhere near commercially made furniture. Every single piece of furniture you see here is an expression of self and passion for giving a new life and use to both brand new products and materials and beautiful pre-loved furniture."
If you love the work below as much as we do, be sure to visit the La ZUZE shop yourself! You can also follow La ZUZE on Pinterest & Facebook. Enjoy!
Posted by: Holly]]>
I'm a complete colour addict & I like to discuss the importance of colour & the endless possibilities through my Make it in Design courses, so it's fascinating to see the differences between colours & how they can produce varying moods & reactions. I'm a huge fan of orange yet according to the graphic it's the colour that most women dislike (but I do have quite a daring & eclectic taste)!
What do you take away from the graphic? Which colours stand out to you? Feel free to share the graphic & find out what your friends & family think.
If you would like more colour inspiration then you can follow my new project Curated Rainbow over on Instagram for a daily dose!
Rachael xoxo
Welcome back to the RT blog! We hope your weekend was brilliant & you're feeling energised by the sunshine, florals out in bloom, the warm weather & all the other wonderful signs of summer.
This weekend we spotted TONS of people out in their gardens, either tending to their own greenery or simply enjoying some Vitamin D. With Rachael also preparing her own garden for the approaching summer & the sights of gardening all around, we though it would be a great idea to feature a fabulous gardening blog called Lovely Greens!
Lovely Greens was created by an avid gardener, DIY-enthusiast & all-around creative named Tanya. In addition to teaching others to grow beautiful & fruitful gardens, Tanya shares tons of advice and tips on edible & organic gardening, DIY, allotments, honeybee-keeping & tons of other fun projects!
Describing the purpose of her blog & what she loves to do, Tanya says, "My mission on Lovely Greens is to show how to live a greener and more garden centred lifestyle… I'm passionate about sharing how to make useful things…How to grow edibles, make handmade soap, and the full process behind garden-inspired crafts and DIYs. I've also set up my own business and when I'm not blogging I'm giving soapmaking lessons and retailing Lovely Greens bath and beauty products."
So whether it's growing your next meal or creating your own skincare products, Lovely Greens is an all-around amazing resource for those who love to be in the garden! You an also follow Tanya's blog & garden photography on IG – here are some of our favourite photos
Posted by: Holly]]>
Today I want to talk about the impact that your drawings can have & about the power that can lie within a single drawn motif.
Taking 'Module 1: Designing Your Way' from Make it in Design (my own e-course!) has been truly amazing, inspiring & motivating. I've loved connecting with the group & having the freedom to just experiment & let loose. It's made me really appreciate the courses even more & I feel so lucky to have our wonderful Make it in Design community around me. I too have to fit the exercises in around my other commitments & like some of our students I'm playing catch up this week ahead of Module 2, which is starting on Monday. It's been so great to experience the class as a real student.
During the module I took part in a lot of the exercises just like the rest of class & completely went back to basics as I experimented with different drawing techniques & media. During class, I created some motifs that I will actually be using in designs that will go into my upcoming Surtex, New York portfolio. This is an EXCLUSIVE sneak peek at brand new designs I have created for the show & they haven't been seen by anyone outside of my studio. I'm giving you this exclusive access to demonstrate the value that a single motif can have.
As you can see, I started out with a simple black & white drawing after following exercise 1.2 in class. I was inspired by seedpods & trees to create this abstract motif. The motif has a bit of a retro vibe to it & that definitely influenced the composition & my colour choices with the rich brown background.
Every single pattern you see on my final presentation sheets has been created with just that one individual motif. How amazing is that?! This is a technique I have used with many of my designs & it is the choice of colour, scale, layering & composition that can really help you to make the most out of your drawings.
Again, I began with a black & white drawing of a tree after being influenced by the inspiration I captured at our local park. I used a slightly thicker weight of pen this time to produce a different effect. Whilst listening to my favourite music, I began doodling away & just let loose. Module 1 has definitely awakened my visual senses more as I'm documenting so many textures & patterns that are around me on a day-to-day basis – I'm really noticing hidden beauty in the most mundane objects.
It really is unbelievable what you can do with a motif once you start to experiment with its orientation & scale. My simple tree drawing has been transformed into three very different designs all because of some simple experimentation with composition.
This is ultimately what I hope to teach in the courses: the power & the potential of surface pattern design! Look at all of the possibilities! There truly is a place for everyone in this industry & I really hope you'll join me on this creative journey.
Rachael xoxo
(Please note: although these designs are based on one motif, we do explore more complex designs, patterns & techniques that combine various motifs. This occurs through a natural progression of the modules, along with exploration in various genres, media types & a wide range of styles.)
P.S. As a bonus I've recorded a number of extra videos across my social media accounts along with a few Facebook lives. I will continue to do this & share sneak peeks behind the scenes, as well as posting my own Module 2 progress. The class seemed to especially love taking a look at all of my portfolio books that have never been seen before!
If you've already completed Module 2 but want to keep involved with my progress, don't worry! We have a fabulous team at Make it in Design who will share everything in the Module 3 private Facebook group as well. I want to make sure everyone feels as inspired as possible!
If you want to know a little more of what you'll learn in Modules 2 & 3, below is a quick peek at what you can expect to find! Our acclaimed modules really do provide you with the essential building blocks for a successful career in surface pattern design, so we encourage you to follow your dreams & sign up today!
Module 2 teaches you:
Module 3 teaches you:
We hope you're all having an absolutely amazing week!
Today we want to encourage you all to broaden your horizons – whether that's taking up a new hobby, going somewhere you've never been, trying something new, or even changing your career path, we encourage you to give it a try! After all, who knows what exciting adventures are just around the corner.
Have a fun & adventurous weekend everyone!
Posted by: Holly]]>
If you're anything like the RT Team, you're a lover of accessories. From hair clips and earrings to rings, necklaces & bracelets, we are huge fans of bringing personality, style & colour to our outfits with the 'extras,' as they really can make a statement or complete an outfit!
One thing every accessory lover will have experienced is the struggle to keep their bits & bobs organised. After all, not all accessories suit the season, your mood, or your outfit, so some may need to be stored away. But for those of us who love our collections and have 'favourite' pieces, it seems a shame to hide them in a jewellery box or in a drawer. It deserves to be on display!
With that in mind, we recently took to IG to see what others had been doing with their accessories & to find out if there was a stylish, interiors-friendly way to show off our rings & things. As it turns out, the handmade ceramics industry has us covered, as crafters from all over the world have begun to craft super chic & trendy ring dishes, earring holders, necklace racks & more.
Needless to say, we fell in love! With all these fabulous little dishes, we found it easy to organise our collections & thought that these little ornaments added an extra bit of style to our homes. So if you're an avid accessory wearer & want to keep your collection on display, be sure to check out the shops & makers featured below, or take a peek at Rachael's licensed 'Bling Boxes' with Deny Designs, which an hold over 300 pieces & display them inside stylish, colourful case!
Posted by: Holly]]>
In January I announced that I would be joining The Art & Business of Surface Pattern Design e-course as a fellow classmate (for the 1st time ever)! It's been such an amazing experience to get to sit down & design with my classmates & the community.
You can keep up with my progress over on Instagram (& if you are taking Module 2 on April 24th you can also join this private FB group where I will be sharing how I get on). I will also be doing a few Facebook lives from my studio!
As the course leader I'm always heavily involved with the community on a weekly & daily basis, but this time I won't just be the teacher I'll be a participating student in live & real time. I wanted to really push myself during 2017 & take on some creative challenges so I'm thrilled to have cleared my schedule to allow this creative freedom to follow my own e-courses that I host with my sister company Make it in Design. I will be joining Module 2: Creating Your Professional Identity, which begins on April 24th & runs for 5 weeks. I'm exciting to start taking a fresh new look at my brand as well as getting to play with the numerous templates provided in the course.
I feel so motivated by this wonderful community & ready too push my own design portfolio further. The courses have reached over 7000 students from 65 countries in 5 years & what better way to celebrate the magic & grow as a designer than to take part!
Welcome back to the RT Blog! We hope you had an absolutely AMAZING Easter Weekend & that the Easter Bunny was kind to you all!
If you follow any fashion / interiors bloggers online, one trend you may have noticed popping up is the apartment tour. From all over the globe, bloggers everywhere have been keen to show their fans what their homes look like & love to offer up tips on where to buy, where they find inspo & more!
We recently shared one of these tours in our Blogs We Love series – Kate La Vie takes us around her whole apartment (which is absolutely gorgeous) – take a peek here! We loved it so much, we thought it would be fun to explore the other apartment / home tours on IG. It's always fun & super interesting to see inside the decor sense & the homes of other creatives (even one's you've never met!)
Needless to say, we loved the results of our search & have come away with lots of fresh ideas. We can never get over how easy it is to find inspo on IG as well – we simply searched tags like #hometour, #apartmenttour, #myhome, #cornerofmyhome & voila – a sea of stylish, on-trend inspiration at our fingertips!
Below we've chosen some of our favs & have also included some colourful & fun images that Rachael has shared from inside her home! But we encourage you to do your own exploring to see the wealth of inspo that these tags bring up! Who knows, they might just send you on a Spring-time redecorating frenzy!
Posted by: Holly
Wow – we can't believe Easter is here again! This is definitely one of our favourite times of year, especially with all the colourful fun that comes with Easter celebrations.
Whether it's egg painting, bonnet making, tree decorating, card making, or flower arranging, there really is so much creative fun to be had this weekend!
Today, we want to share one of Rachael's bright Easter designs to get you excited for this weekend's festivities! Have a brilliant time with your family & friends everyone!
Posted by: Holly]]>


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Right in the middle of Baddeck, it was pleasant to sit outside and our server was friendly and nice. But food really not good at all: haddock tasteless except for sodden breadcrumbs, floury chowder, etc. Lots of better food choices in the area.
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Chinese Langtern Festival (9 img)
Started Nov 23, 2012 | Discussions thread
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kgwhite • Veteran Member • Posts: 4,570
Re: Chinese Langtern Festival (9 img)
In reply to John.Laninga • Nov 24, 2012
Very well done. Nicely controlled exposures. love the color.
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Comfortably nestled in the middle of the bustling Ortigas Center district, right at the crossroads of EDSA, One Shangri-La Place is conveniently situated in the center of Shangri-La community. It is also conveniently located near business institutions such as the San Miguel Corporation and the Philippine Stock Exchange, prestigious schools including Poveda, the University of Asia and the Pacific, La Salle Greenhills, and modern hospitals like the Medical City and Cardinal Santos Medical Center, making it a prime place for every family and working professional.
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Mar 29, 2017 ... Leanr how to dye hard boiled eggs with food coloring. It's less expensive than buying a kit and quite easy to do.
1 dozen large eggs; Vinegar; McCormick® Assorted Food Colors & Egg Dye ... Mix 1/2 cup boiling water, 1 teaspoon vinegar and 10 to 20 drops food color in a ... Use a slotted spoon, wire egg holder or tongs to add and remove eggs from dye.
Use these five simple steps for adding a coat of color to those hard-boiled ... 1 teaspoon white vinegar; Liquid food coloring (about 20 drops per color) ... Or if you'd prefer to use all-natural dyes, get the recipes for Homemade Easter Egg Dyes.
This recipe uses liquid food coloring, but you can also use paste. Experiment with combining different colors to produce new shades—for instance, 17 drops of ...
Instructions and recipe for using food coloring to dye easter eggs.
Create brightly colored eggs this Easter using Wilton Gel Food Colors or Icing ... Using a toothpick, dissolve Wilton Gel Food Color or Icing Color until water is ...
Dip hard-cooked eggs in dye bath for 3-5 minutes, extend time for richer color. Try using tongs to dip only half an egg in one color, then dip other half in a ...
Mar 17, 2016 ... How to dye Easter eggs. ... Egg Dyeing 101. Martha's Good Eggs: Best Use of Color. Martha's Good Eggs: Best Use of Color.
Easter Eggs fun ways to dye Easter Eggs, Did you know you can do it with RICE and Food Color and it turns out amazing, Easter hacks, Speckled Eggs, Popular ...
Apr 3, 2015 ... a great and food safe way to dye your hard boiled eggs.


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Fort Smith Tourism & Travel Guide
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We visited Fort Williams in Highlands and Glenbrittle, Aird of Sleat, Elgol, Dunvegan, Portree in Isle of Skye. ...
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10452Re: [GIWorld-Hepatitis] Another question/Nutrition
Expand Messages
- Jun 6, 2002Ask a 100 people about the 'right' diet and you will get a 100
different answers. So - here's mine!
I don't think there is any 'magic' diet, or one that is the 'right'
one for everyone. Everybody is different. I think the most important
thing is to eat a low fat, well balanced diet, and don't eat any
iron-fortified foods. (That is mostly processed breakfast cereals).
Try to eat a variety of foods. Remember those 'food groups' you
learned about in school? I think that is still the most important
guide line. Lean meats, chicken, eggs, or other protein sources;
whole grain breads and cereals, vegetables, low-fat or skim milk,
cheese, yogurt, lots of veggies and fruits - the fresher the better.
And start with what you like! If you try to make a bunch of drastic
changes you probably won't stick with it. Those nutritional
supplement drinks are ok, just read the labels before buying. Some
have a higher iron count than others, and go with low-fat. Also,
drink lots of water.
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Audio interviews with industry leaders and senior faculty with exclusive insights on current topics brought to you by [email protected] and the Wharton School of the University of Pennsylvania.
March 6th, 2013
Episode 72 of 814 episodes
Whether you are an educator, an art director or a project manager, you are in sales. So argues bestselling author Daniel Pink in his new book, To Sell Is Human: The Surprising Truth about Moving Others. Pink recently visited the University of Pennsylvania as a guest lecturer in the [email protected] series. Wharton management professor Adam M. Grant interviewed Pink while he was there to learn more about the ideas in his book, including whyconsumers mistrust salespeople, what the new ABCs of selling are and why questions may be the greatest selling tool. (Video with transcript)
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Documents show PETA killed nearly 2,000 shelter animals in 2013
- Animal rights group says its doing what's best for the animals in its Virginia shelter but critics point to unseemly 82 percent kill rate
- According to the Center for Consumer Freedom, PETA has killed over 31,000 animals since 1998
Animal rights group PETA may go to extreme lengths to save animals from the slaughterhouse but the Virginia-based organization's animal shelter killed nearly 2,000 cats and dogs at its shelter in 2013.
The Center for Consumer Freedom released its annual review of PETA's Norfolk shelter and it shows a surprising 82 percent euthanization rate.
Despite outcries from some fellow animal activists, PETA has declined to change its policies since 1998. Since that year, the shelter has put down over 31,000 animals, most of which it insists are injured or unadoptable.
Better off? People for the Ethical Treatment of Animals has a surprising track record at its Norfolk animal shelter. Publicly availanle Virginia records show that PETA kills 82 percent of its animals. PETA says about half those creatures are unadoptable
The Center for Consumer Freedom points out that PETA killed 1,792 cats and dogs in 2013 (FILE PHOTO: This shelter is not a PETA shelter)
Countless celebrities have posed for PETA ads like this one featuring Khloe Kardashian. But would they have changed their mind had they known of the group's shelter activities?
These numbers come from the Virginia
Department of Agriculture and Consumer Services (VDACS), which requires
such annual disclosures.
2013, PETA killed 1,792 cats and dogs, an average of 5 per day.
The 1,792 figure represents 82 percent of all animals PETA took into its
shelter throughout the year.
'This delusional animal rights group is talking out of both sides of its mouth – on one side preaching animal rights, while on the other signing the death warrant of 82 percent of cats and dogs in its care. Labeling PETA as hypocritical would be the understatement of the year,' said Will Coggin from the Center for Consumer Freedom.
In 2005, two PETA employees were arrested in North Carolina after allegedly killing adoptable pets and tossing the bodies into a supermarket trash dumpster.
Trial evidence showed they killed animals they described as 'perfect' and 'adorable.'
Defendants Adria Hinkle and Andrew Cook were tried and cleared of all charges in 2007.
PETA disagrees and even released its own numbers in a statement this week:
'PETA's shelter took in and euthanized 1,805 elderly, feral, sick, dying, aggressive, and otherwise unadoptable animals—more than 400 of whom were brought to PETA by loving but destitute guardians desperate to alleviate their beloved animals' suffering and many others who had been turned away by local so-called "no-kill" facilities that reject unadoptable animals in order to keep their euthanasia statistics appealing.'
PETA President Ingrid Newkirk previously indicated to The Virginian-Pilot that the animal rights group could stop killing pets any time they want.
'We could become a no-kill shelter immediately. It means we wouldn't do as much work,' she said.
According to VDAS, in 2010 discovered that 84 percent of the animals PETA took in were killed within 24 hours.
'PETA's so-called 'shelter' might as well be called a slaughterhouse,' said CCF. 'For an organization that once disgustingly compared the treatment of farm animals to the Holocaust, you'd think PETA would avoid the appearance of systematic killing.'
Meanwhile, PETA Senior Vice President Daphna Nachminovitch emphasized the pets that could be saved.
'The nearly 400 adoptable animals PETA received were placed in carefully screened, permanent homes or transferred to the Virginia Beach SPCA and other high-traffic open-admission shelters for a chance to be adopted,' she said.
Since 1998, PETA's shelter has euthanized over 31,000 animals. PETA maintains most of those animals are unadoptable and that euthanasia is preferable in many cases to a life struggling on the streets (FILE PHOTO: This shelter is not a PETA shelter)
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Lean and Six Sigma Glossary
Subscribe below and start learning the Lean and Six Sigma lingo today.
Balance in terms of lean six sigma refers to the even distribution of work elements throughout an organization. A state of balance would be an organization that levels distribution of "hands" performing work and keeps equal or level working times amongst the different types of operations found within the organization.
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Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.
A common symptom during late stage breast cancer disease is pleural effusion, which is related to poor prognosis. Malignant cells can be detected in pleural effusions indicating metastatic spread from the primary tumor site. Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties. For the present study, pleural effusion aspirates from 17 metastatic breast cancer patients were processed to propagate CSCs in vitro. Patient-derived aspirates were cultured under sphere forming conditions and isolated primary cultures were further sorted for cancer stem cell subpopulations ALDH1+ and CD44+CD24-/low. Additionally, sphere forming efficiency of CSC and non-CSC subpopulations was determined. In order to genetically characterize the different tumor subpopulations, DNA was isolated from pleural effusions before and after cell sorting, and compared with corresponding DNA copy number profiles from primary tumors or bone metastasis using low-coverage whole genome sequencing (SCNA-seq). In general, unsorted cells had a higher potential to form spheres when compared to CSC subpopulations. In most cases, cell sorting did not yield sufficient cells for copy number analysis. A total of five from nine analyzed unsorted pleura samples (55%) showed aberrant copy number profiles similar to the respective primary tumor. However, most sorted subpopulations showed a balanced profile indicating an insufficient amount of tumor cells and low sensitivity of the sequencing method. Finally, we were able to establish a long term cell culture from one pleural effusion sample, which was characterized in detail. In conclusion, we confirm that pleural effusions are a suitable source for enrichment of putative CSC. However, sequencing based molecular characterization is impeded due to insufficient sensitivity along with a high number of normal contaminating cells, which are masking genetic alterations of rare cancer (stem) cells.
Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey.
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1.5%. Patients with RA were older and more female predominant than subjects without RA. The prevalence of living in an urban area, college graduation, alcohol consumption and smoking was lower in patients with RA than non-RA. Patients with RA had more comorbidities including hypertension, dyslipidemia, myocardial infarction (MI) or angina, stoke, osteoarthritis, lung cancer, colon cancer, pulmonary tuberculosis, asthma, diabetes, depression, thyroid disease and chronic kidney disease. After adjusting socioeconomic and lifestyle characteristics, RA was associated with an increased prevalence of MI or angina (OR 1.86, 95% CI 1.17-2.96, p = 0.009), pulmonary TB (OR 1.95, 95% CI 1.24-3.09, p = 0.004), asthma (OR 1.97, 95% CI 1.05-3.71, p = 0.036), thyroid disease (OR 1.71, 95% CI 1.05-2.77), depression (OR 2.38, 95% CI 1.47-3.85, p < 0.001) and hepatitis B (OR 2.34, 95% CI 1.15-4.80, p = 0.020) compared with the non-RA population. Prevalence of solid cancer was not significantly associated with RA after adjustment.
Correlation of EGFR or KRAS mutation status with 18F-FDG uptake on PET-CT scan in lung adenocarcinoma.
18F-fluoro-2-deoxy-glucose (18F-FDG) positron emission tomography (PET) is a functional imaging modality based on glucose metabolism. The correlation between EGFR or KRAS mutation status and the standardized uptake value (SUV) of 18F-FDG PET scanning has not been fully elucidated.
Radiofrequency versus microwave ablation for treatment of the lung tumours: LUMIRA (lung microwave radiofrequency) randomized trial.
The LUMIRA trial evaluated the effectiveness of radiofrequency (RFA) and microwave ablation (MWA) in lung tumours ablation and defining more precisely their fields of application. It is a controlled prospective multi-centre random trial with 1:1 randomization. Fifty-two patients in stage IV disease (15 females and 37 males, mean age 69 y.o., range 40-87) were included. We randomized the patients in two different subgroups: MWA group and RFA group. For each group, we evaluated the technical and clinical success, the overall survival and complication rate. Inter-group difference was compared using Chi-square test or Fisher's exact test for categorical variables and one-way ANOVA test for continuous variables. For RFA group, there was a significant reduction in tumour size only between 6 and 12 months (p value = 0.0014). For MWA group, there was a significant reduction in tumour size between 6 and 12 months (p value = 0.0003) and between pre-therapy and 12 months (p value = 0.0215). There were not significant differences between the two groups in terms of survival time (p value = 0.883), while the pain level in MWA group was significantly less than in RFA group (1.79 < 3.25, p value = 0.0043). In conclusion, our trial confirms RFA and MWA are both excellent choices in terms of efficacy and safety in lung tumour treatments. However, when compared to RFA therapy, MWA produced a less intraprocedural pain and a significant reduction in tumour mass.
DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.
Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We sought to determine whether genome-wide lung DNA methylation profiles of smokers and patients with COPD were significantly different from non-smokers. We isolated DNA from parenchymal lung tissues of patients including eight lifelong non-smokers, eight current smokers, and eight patients with COPD and analyzed the samples using Illumina's Infinium HumanMethylation450 BeadChip.
Women Epidemiology Lung Cancer (WELCA) study: reproductive, hormonal, occupational risk factors and biobank.
Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors.
The treatment of primary mediastinal large B-cell lymphoma: a two decades monocentric experience with 98 patients.
The purpose of this study is to investigate the most suitable first-line approach and the best combination treatment for primary mediastinal large B-cell lymphoma (PMLBCL) as they have been matter of debate for at least two decades.
Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway.
Radiotherapy is a powerful tool in the treatment of cancer that has the advantage of preserving normal tissues. However, tumor radioresistance currently remains a major impediment to effective RT. Thus, exploring effective radiation sensitizers is urgently needed. In this study, we have shown that diosmetin, the aglycone of the lavonoid glycoside from olive leaves, citrus fruits and some medicinal herbs, has a promising effect on radiotherapy sensitization. In our results, DIO could induce G1 phase arrest and thus enhance the radiosensitivity of radioresistant A549/IR lung cancer cells. Furthermore, DIO also restrains the IR-induced DNA damage repair by inhibiting the activated Akt signaling pathway. The combination of Akt inhibition (DIO, LY294002 or MK-2206) and radiation potently blocked A549/IR cancer cell proliferation. In summary, these observations suggest that the natural compound DIO could act as a potential drug for the treatment of radioresistant lung cancer cells.
Voice disorder in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a chronic disease characterized by progressive tissue damage. In recent decades, novel treatments have greatly extended the life span of SLE patients. This creates a high demand for identifying the overarching symptoms associated with SLE and developing therapies that improve their life quality under chronic care. We hypothesized that SLE patients would present dysphonic symptoms. Given that voice disorders can reduce life quality, identifying a potential SLE-related dysphonia could be relevant for the appraisal and management of this disease. We measured objective vocal parameters and perceived vocal quality with the GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) scale in SLE patients and compared them to matched healthy controls. SLE patients also filled a questionnaire reporting perceived vocal deficits. SLE patients had significantly lower vocal intensity and harmonics to noise ratio, as well as increased jitter and shimmer. All subjective parameters of the GRBAS scale were significantly abnormal in SLE patients. Additionally, the vast majority of SLE patients (29/36) reported at least one perceived vocal deficit, with the most prevalent deficits being vocal fatigue (19/36) and hoarseness (17/36). Self-reported voice deficits were highly correlated with altered GRBAS scores. Additionally, tissue damage scores in different organ systems correlated with dysphonic symptoms, suggesting that some features of SLE-related dysphonia are due to tissue damage. Our results show that a large fraction of SLE patients suffers from perceivable dysphonia and may benefit from voice therapy in order to improve quality of life.
Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.
Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV.
The ET-1-mediated carbonylation and degradation of ANXA1 induce inflammatory phenotype and proliferation of pulmonary artery smooth muscle cells in HPS.
Hepatopulmonary syndrome (HPS) is a serious complication of advanced liver disease, which markedly increases mortality. Pulmonary vascular remodelling (PVR) induced by circulating mediators plays an important role in the pathogenesis of HPS, while the underlying mechanism remains undefined. In the present study, we reported that endothelin-1 (ET-1) is up-regulated and annexin A1(ANXA1) is down-regulated in HPS rat, and ET-1 decreases the ANXA1 expression in a dose-dependent manner in rat pulmonary arterial smooth muscle cells (PASMCs). Then, we showed that ANXA1 can decrease nuclear p-ERK1/2 accumulation and decrease the cyclin D1 expression, thus resulting in the subsequent inhibition of PASMCs proliferation. As previously reported, we confirmed that ET-1 decreases the ANXA1 protein levels by the carbonylation and degradation of ANXA1. In conclusion, our research links the signaling cascade of ET1-ANXA1-cell proliferation to a potential therapeutic strategy for blocking IPS-associated PVR.
Advances in the Prevention and Treatment of High Altitude Illness.
High altitude illness encompasses a spectrum of clinical entities to include: acute mountain sickness, high altitude cerebral edema, and high altitude pulmonary edema. These illnesses occur as a result of a hypobaric hypoxic environment. Although a mild case of acute mountain sickness may be self-limited, high altitude cerebral edema and high altitude pulmonary edema represent critical emergencies that require timely intervention. This article reviews recent advances in the prevention and treatment of high altitude illness, including new pharmacologic strategies for prophylaxis and revised treatment guidelines.
Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC).
Patients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role of low-density lipoprotein (LDL) and low-density lipoprotein- cholesterol (LDLR) in patients with SCLC has not been studied.
Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population.
Non-small cell lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. rs12220909 (G/C) genetic polymorphism in miR-4293 has been shown to be associated with decreased risk of esophageal squamous cell carcinoma. However, the influence of rs12220909 genetic variation on non-small cell lung cancer susceptibility has not been reported. In order to evaluate the potential association between miR-4293 rs12220909 and non-small cell lung cancer risk in a Chinese population, we performed a case-control study among 998 non-small cell lung cancer cases and 1471 controls. The data shows that miR-4293 rs12220909 was significantly associated with decreased susceptibility to non-small cell lung cancer (GC vs.GG: OR = 0.681, 95%CI = 0.555-0.835, P = 2.19E-4; GG vs. GC+CC: OR = 0.687, 95%CI = 0.564-0.837, P = 1.95E-4), which indicates that rs12220909 in miR-4293 may play a significant role in the development of non-small cell lung cancer.
Diabetes mellitus in patients with chronic obstructive pulmonary disease-The impact on mortality.
Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. There is evidence to support a connection between COPD and diabetes mellitus (DM), another common medical disorder. However, additional research is required to improve our knowledge of these relationships and their possible implications. In this study, we investigated the impact of DM on patient outcomes through the clinical course of COPD.
Real-world treatment patterns for patients receiving second-line and third-line treatment for advanced non-small cell lung cancer: A systematic review of recently published studies.
Most patients with advanced non-small cell lung cancer (NSCLC) have a poor prognosis and receive limited benefit from conventional treatments, especially in later lines of therapy. In recent years, several novel therapies have been approved for second- and third-line treatment of advanced NSCLC. In light of these approvals, it is valuable to understand the uptake of these new treatments in routine clinical practice and their impact on patient care. A systematic literature search was conducted in multiple scientific databases to identify observational cohort studies published between January 2010 and March 2017 that described second- or third-line treatment patterns and clinical outcomes in patients with advanced NSCLC. A qualitative data synthesis was performed because a meta-analysis was not possible due to the heterogeneity of the study populations. A total of 12 different study cohorts in 15 articles were identified. In these cohorts, single-agent chemotherapy was the most commonly administered treatment in both the second- and third-line settings. In the 5 studies that described survival from the time of second-line treatment initiation, median overall survival ranged from 4.6 months (95% CI, 3.8-5.7) to 12.8 months (95% CI, 10.7-14.5). There was limited information on the use of biomarker-directed therapy in these patient populations. This systematic literature review offers insights into the adoption of novel therapies into routine clinical practice for second- and third-line treatment of patients with advanced NSCLC. This information provides a valuable real-world context for the impact of recently approved treatments for advanced NSCLC.
Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015.
The neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are commonly used for the treatment and control of influenza A and B virus infection. However, the emergence of new influenza virus strains with reduced susceptibility to NAIs may appear with the use of these antivirals or even naturally. We therefore screened the neuraminidase (NA) sequences of seasonal influenza virus A(H1N1), A(H1N1)pdm09, A(H3N2), and influenza B virus strains identified in Thailand for the presence of substitutions previously reported to reduce susceptibility to NAIs. We initially examined oseltamivir resistance (characterized by the H275Y mutation in the NA gene) in 485 A(H1N1)pdm09 strains circulating in Thailand and found that 0.82% (4/485) had this substitution. To further evaluate the evolution of the NA gene, we also randomly selected 98 A(H1N1)pdm09, 158 A(H3N2), and 69 influenza B virus strains for NA gene amplification and sequencing, which revealed various amino acid mutations in the active site of the NA protein previously shown to be associated with reduced susceptibility to NAIs. Phylogenetic analysis of the influenza virus strains from this study and elsewhere around the world, together with the estimations of nucleotide substitution rates and selection pressure, and the predictions of B-cell epitopes and N-linked glycosylation sites all provided evidence for the ongoing evolution of NA. The overall rates of NA evolution for influenza A viruses were higher than for influenza B virus at the nucleotide level, although influenza B virus possessed more genealogical diversity than that of influenza A viruses. The continual surveillance of the antigenic changes associated with the NA protein will not only contribute to the influenza virus database but may also provide a better understanding of selection pressure exerted by antiviral use.
Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections.
Characterization of Staphylococcus aureus clinical isolates derived from lower respiratory tract infections (LRTIs), and correlation between the functionality of the accessory gene regulator (Agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome.
Plasma from patients with anti-glomerular basement membrane disease could recognize microbial peptides.
Infection has long been suspected as a trigger of autoimmune diseases, and molecular mimicry mechanism was hypothesized in this study. Microbe originated peptides were searched from the Uniprot database based on a previous defined critical amino acid motif within α3129-150, isoleucine137, tryptophan140, glycine142, phenylalanine 143 and phenylalanine 145. 23826 microbial peptides were identified using our searching strategy, among which seven were related with human infections. Circulating IgG and IgM antibodies against the seven microbial peptides were detected using ELISA in 76 patients with anti-GBM disease. Four peptides were recognized by both IgG and IgM antibodies, and one peptide was recognized by IgG antibodies only. Peptides from Bacteroides, Saccharomyces cerevisiae, and Bifidobacterium thermophilum possessed the highest recognition frequency with the prevalence of 73.7%, 61.8% and 67.1% for IgG, 56.6%, 44.7% and 67.1% for IgM in anti-GBM patients. Patients with antibodies against these microbial peptides showed more severe kidney injury, including higher serum creatinine and higher percentage of crescent formation. In conclusion, antibodies against microbial peptides were identified in the circulation of anti-GBM patients, implying its etiological role in eliciting autoimmune response against α3(IV)NC1 through molecular mimicry.
Peritonsillar abscess is the most common deep infection of the head and neck, occurring primarily in young adults. Diagnosis is usually made on the basis of clinical presentation and examination. Symptoms and findings generally include fever, sore throat, dysphagia, trismus, and a "hot potato" voice. Drainage of the abscess, antibiotic therapy, and supportive therapy for maintaining hydration and pain control are the cornerstones of treatment. Most patients can be managed in the outpatient setting. Peritonsillar abscesses are polymicrobial infections, and antibiotics effective against group A streptococcus and oral anaerobes should be first-line therapy. Corticosteroids may be helpful in reducing symptoms and speeding recovery. Promptly recognizing the infection and initiating therapy are important to avoid potentially serious complications, such as airway obstruction, aspiration, or extension of infection into deep neck tissues. Patients with peritonsillar abscess are usually first encountered in the primary care outpatient setting or in the emergency department. Family physicians with appropriate training and experience can diagnose and treat most patients with peritonsillar abscess.
Chronic Obstructive Pulmonary Disease: Diagnosis and Management.
The diagnosis of chronic obstructive pulmonary disease (COPD) should be suspected in patients with risk factors (primarily a history of smoking) who report dyspnea at rest or with exertion, chronic cough with or without sputum production, or a history of wheezing. COPD may be suspected based on findings from the history and physical examination, but must be confirmed by spirometry to detect airflow obstruction. Findings that are most helpful to rule in COPD include a smoking history of more than 40 pack-years, a self-reported history of COPD, maximal laryngeal height, and age older than 45 years. The combination of three clinical variables-peak flow rate less than 350 L per minute, diminished breath sounds, and a smoking history of 30 pack-years or more-is another good clinical predictor, whereas the absence of all three of these signs essentially rules out airflow obstruction. Pharmacotherapy and smoking cessation are the mainstays of treatment, and pulmonary rehabilitation, long-term oxygen therapy, and surgery may be considered in select patients. Current guidelines recommend starting monotherapy with an inhaled bronchodilator, stepping up to combination therapy as needed, and/or adding inhaled corticosteroids as symptom severity and airflow obstruction progress.
Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.
Vascular remodelling in hypoxia-induced pulmonary hypertension (PH) is driven by excessive proliferation and migration of endothelial and smooth muscle cells. The expression of aquaporin 1 (AQP1), an integral membrane water channel protein involved in the control of these processes, is tightly regulated by oxygen levels. The role of AQP1 in the pathogenesis of PH, however, has not been directly addressed so far. This study was designed to characterize expression and function of AQP1 in pulmonary vascular cells from human arteries and in the mouse model of hypoxia-induced PH. Exposure of human pulmonary vascular cells to hypoxia significantly induced the expression of AQP1. Similarly, levels of AQP1 were found to be upregulated in lungs of mice with hypoxia-induced PH. The functional role of AQP1 was further tested in human pulmonary artery smooth muscle cells demonstrating that depletion of AQP1 reduced proliferation, the migratory potential, and, conversely, increased apoptosis of these cells. This effect was associated with higher expression of the tumour suppressor gene p53. Using the mouse model of hypoxia-induced PH, application of GapmeR inhibitors targeting AQP1 abated the hypoxia-induced upregulation of AQP1 and, of note, reversed PH by decreasing both right ventricular pressure and hypertrophy back to the levels of control mice. Our data suggest an important functional role of AQP1 in the pathobiology of hypoxia-induced PH. These results offer novel insights in our pathogenetic understanding of the disease and propose AQP1 as potential therapeutic in vivo target.
Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-κB.
Laryngeal carcinoma remains one of the most common malignancies, and curcumin has been proven to be effective against head and neck cancers in vitro. However, it has not yet been applied in clinical settings due to its low stability. In the current study, we synthesized 34 monocarbonyl analogues of curcumin with stable structures. CA15, which exhibited a stronger inhibited effect on laryngeal cancer cells HEp-2 but a lower toxicity on hepatic cells HL-7702 in MTT assay, was selected for further analysis. The effects of CA15 on cell viability, proliferation, migration, apoptosis, and NF-κB activation were measured using MTT, Transwell migration, flow cytometry, Western blot, and immunofluorescence assays in HEp-2 cells. An NF-κB inhibitor, BMS-345541, as well as curcumin was also tested. Results showed that CA15 induced decreased toxicity towards HL-7702 cells compared to curcumin and BMS-345541. However, similar to BMS-345541 and curcumin, CA15 not only significantly inhibited proliferation and migration and induced caspase-3-dependent apoptosis but also attenuated TNF-α-induced NF-κB activation in HEp-2 cells. These results demonstrated that curcumin analogue CA15 exhibited anticancer effects on laryngeal cancer cells via targeting of NF-κB.
Diagnosis of biofilm infections in cystic fibrosis patients.
Chronic Pseudomonas aeruginosa biofilm lung infection in cystic fibrosis patients is the best described biofilm infection in medicine. The initial focus can be the paranasal sinuses and then follows repeated colonization and infection of the lungs by aspiration. The matrix of the biofilms is dominated by alginate and the pathogenesis of tissue damage is immune complex-mediated chronic inflammation dominated by polymorphonuclear leukocytes and their products (DNA, oxygen radicals and proteases). The P. aeruginosa biofilm infection can be diagnosed by microscopy of lung tissue, sputum and mucus from the paranasal sinuses, where aggregates of the bacteria are found surrounded by the abundant alginate matrix. Specific PNA-FISH probes can be used to identify P. aeruginosa and other pathogens in situ in the biofilms. Growth of mucoid colonies from the locations mentioned above is also diagnostic for biofilm infection. Rise of specific anti-P. aeruginosa antibodies is likewise diagnostic, IgG in serum in case of lung infection, sIgA in saliva or nasal secretions in case of paranasal sinus infection. Similar approaches have been developed to diagnose chronic biofilm infections in cystic fibrosis caused by other pathogens e.g., Stenotrophomonas, Burkholderia multivorans, Achromobacter xylosoxidans and Mycobacterium abscessus complex.
Biofilms and host response - helpful or harmful.
Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response.
In vitro studies of Pseudomonas aeruginosa and other pathogenic bacteria in biofilm aggregates have yielded detailed insight into their potential growth modes and metabolic flexibility under exposure to gradients of substrate and electron acceptor. However, the growth pattern of P. aeruginosa in chronic lung infections of cystic fibrosis (CF) patients is very different from what is observed in vitro, for example, in biofilms grown in flow chambers. Dense in vitro biofilms of P. aeruginosa exhibit rapid O2 depletion within <50-100 μm due to their own aerobic metabolism. In contrast, in vivo investigations show that P. aeruginosa persists in the chronically infected CF lung as relatively small cell aggregates that are surrounded by numerous PMNs, where the activity of PMNs is the major cause of O2 depletion rendering the P. aeruginosa aggregates anoxic. High levels of nitrate and nitrite enable P. aeruginosa to persist fueled by denitrification in the PMN-surrounded biofilm aggregates. This configuration creates a potentially long-term stable ecological niche for P. aeruginosa in the CF lung, which is largely governed by slow growth and anaerobic metabolism and enables persistence and resilience of this pathogen even under the recurring aggressive antimicrobial treatments of CF patients. As similar slow growth of other CF pathogens has recently been observed in endobronchial secretions, there is now a clear need for better in vitro models that simulate such in vivo growth patterns and anoxic microenvironments in order to help unravel the efficiency of existing or new antimicrobials targeting anaerobic metabolism in P. aeruginosa and other CF pathogens. We also advocate that host immune responses such as PMN-driven O2 depletion play a central role in the formation of anoxic microniches governing bacterial persistence in other chronic infections such as chronic wounds.
Positional therapy in sleep apnoea - one fits all? What determines success in positional therapy in sleep apnoea syndrome.
Positional therapy is a simple means of therapy in sleep apnoea syndrome, but due to controversial or lacking evidence, it is not widely accepted as appropriate treatment. In this study, we analysed data to positional therapy with regard to successful reduction of AHI and predictors of success.
Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity.
Chemotherapeutic agents are generally used as a frontline therapy for non-small cell lung cancer (NSCLC). However, resistance to chemotherapy arises rapidly in NSCLC, and the reasons for chemotherapy resistance have not been fully determined. Here, we found cisplatin, but not paclitaxel and doxorubicin, induced the enrichment of cancer stem cell (CSC) and conferred multidrug resistance in NSCLC cell lines. In vivo study confirmed drug-resistant tumors displayed the enhanced expressions of CSC transcription factors. Mechanistically, cisplatin treatment resulted in C/EBP-β-dependent increasing of TRIB1. The crucial role of TRIB1 in cisplatin-induced enrichment of CSC and drug resistance was verified by knockdown TRIB1. Interestingly, cisplatin treatment also contributed to the increasement of HDAC, the interaction of TRIB1 with HDAC, and inactivation of p53. Similarly, the silencing of HDAC led to reduction of cisplatin-induced CSC, and combined knockdown of HDAC and TRIB1 exhibited enhanced effect. Additionally, the combination of HDAC inhibitor and cisplatin showed a reinforced antitumor action in NSCLC cell lines with TRIB1-dependent manner and remarkably shrink tumors in xenograft models. Moreover, cisplatin-treated NSCLC patients with high levels of TRIB1 exhibited a significantly poorer prognosis. Our findings illustrate a novel perspective in the evolution of chemotherapy resistance and provide a promising approach for the treatment of patients with NSCLC.
WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.
WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung cancer (NSCLC) and it accelerates cell proliferation in NSCLC. However, the detailed mechanism underlying the role of WDR79 in the proliferation of NSCLC cells remains unclear. Here, we report the discovery of a molecular interaction between WDR79 and USP7 and show its functional significance in linking the Mdm2-p53 pathway to the proliferation of NSCLC cells. We found that WDR79 colocalized and interacted with USP7 in the nucleus of NSCLC cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53, thereby increasing the stability and extending the half-life of the two proteins. We further found that the functional effects of WDR79 depended upon USP7, because the knockdown of USP7 resulted in their attenuation. Finally, we demonstrated that WDR79 promoted the proliferation of NSCLC cells via USP7. Taken together, our findings reveal a novel molecular function of WDR79 and may lead to broadly applicable and innovative therapeutic avenues for NSCLC.


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That looks like a beautiful place..I understand though your sentiment towards a relaxing vacation, I prefer discovering culture and art too when I travel. But what a place!
Have a nice day,
Such a beautiful photos, I never been there! I love to travel also! xo
Gorgeous pictures!!! Would love to go there <3
Great blog! Do you have any suggestions for aspiring writers? I'm hoping to start my own site soon but I'm a little lost on everything. Would you advise starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I'm totally overwhelmed… Any suggestions? Thank you!


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Nursery rooms
starry ceiling
Mee likes it. An adorable little owl lamp from @homegoods is the perfect addition to this soft and sweet little girl's nursery with huge paper flowers over the crib. (sponsored pin)
Button Art Crescent Moon and Stars Gamma Phi Beta by BellePapiers, $84.00
Pink grey and gold glamorous girl's nursery.
JENN LIKES THIS..... Use an old wagon as a rolling book cart or could use a newer one as a toy chest so kids can bring it wherever in the house you want them playing... and then clean up and move it back to their room when playtime is up for they day :)
Love the different sized frames for the letters and the curtains!! Planning on framing our new bed with curtains in our new bedroom. Can't wait for it to get finished!! ~P
This mobile reminds me of a sweet lullaby! Add a soft dreaminess to your nursery room with this adorable mobile! Four fluffy clouds and faceted
Love this nursery - so calming.
Project Nursery - Baby Room Pics 036. Bathroom
babyrum 3


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can I use two day old leftover plain rice which had been chilled immedietley and put in airtight containers in the fridge
Chops is a trusted home cook.
Yes! Make some fried rice!
Sure! I would use it for several days.
If you make a salad with vinaigrette dressing, you can extend the keeping time.
Bacillus cereus, similar to Clostridium botulinum, is commonly found in rice and other grains, beans, and other dry foods. Spores can survive the cooking process and replicate in warm, moist environments producing deadly toxins in the process. Prompt refrigeration will keep the bacteria under control but, since it only retards their growth, leftovers should be consumed within a few days.
I have a theory that B. cereus is responsible for at least some of the symptoms for which people blame MSG. Back in the 70's, before our current knowledge of the bacterium evolved, Chinese restaurants commonly left unused rice unrefrigerated overnight before turning it into fried rice the next day.
amysarah is a trusted home cook.
I often make rice to use a couple of days later for fried rice. To cool it down quickly, I sometimes put it in the fridge spread in a thin layer on a baking sheet with sides - then pile it into an airtight container once it's cold.
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Latest PostsApril 12, 2016Amy JonesUncategorizedThere is no excerpt because this is a protected post.
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March 17, 2016Amy JonesEditor's Picks
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Editor's PickAmy JonesEditor's PicksMarch 11, 2016Amy JonesArt JournalingEditor's PicksMake: Mixed Media Art ProjectsWatch previews and find out about 4 new hand lettering instructional videos from artist Joanne Sharpe, author of The Art of Whimsical Lettering.
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The Creative LifeApril 25, 2014Rice Freeman-ZacheryThe Creative Life: A Mixed Media BlogToday we feature a podcast with Sal and Ellen, the creators of Art Is You retreats, as they talk about Living in Generosity.
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Destination: Creativity~~ Art & Soul
As I mentioned last week, my new book, Destination: Creativity--The Life-Altering Journey of the Art Retreat, has just been released. In the process of traveling to all the art retreats for this project, my photographer (also my husband, also known as The Ever-Gorgeous Earl) took rather a lot of photographs. Thousands of photographs. Many thousands of photographs. And since the book isn't a huge, multi-volume behemoth, most of those photographs didn't make it into the book, alas. Even some of my favorites--there just wasn't enough room. So I'm going to be sharing some of those, mostly over on my blog, Notes from the Voodoo Cafe, but also here. I wanted to start with Art and Soul because we're getting ready to go to its Portland incarnation at the end of this month. We'll have a book signing there, so if you're in the neighborhood, be sure to check it out. Glenny Desem-Moire started Art & Soul in 2002 with its flagship retreat in Portland. Since then, there have been Art & Soul retreats in Dallas, Asilomar, Virginia Beach, and Las Vegas. We went to the inaugural event in Las Vegas in 2010 and then, months later, to Virginia Beach. Here are some photos from the latter. For even more cool photos, go here. These (above) were some of the goodies in the shop that was open all day every day. I think this was for an electro-forming workshop. Don Madden (below) would know; he had a dead frog to electroform: I think the project, above, is from Michael deMeng's workshop, but I'm not sure. Anybody? Next time we'll have more photos from another retreat. Yay--photos! Ricë also blogs at Notes from the Voodoo Cafe. Find out more on her website. MORE RESOURCES FOR MIXED MEDIA ARTISTS * Find great books, DVDs, downloads & more for mixed media artists! * Sign up for your FREE email newsletter for great tips, projects & more... * Download free mixed media desktop wallpapers!
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'I gave birth to a monster': Russian mother of ISIS poster girl chained her daughter up to try to stop her marrying jihadi... but could not stop the girl reaching Syria where she praises terror atrocities
- Fatime Dzharfarova, 20, travelled to Syria and married an ISIS fighter
- Her mother describes how she desperately tried to stop her from leaving
- Fatima has praised the Paris attacks and promoted ISIS on social media
- Mother Shakhla Bochkaryova, 41, even chained Fatima to a radiator to try and stop her from leaving for Syria
- See full news coverage of ISIS at www.dailymail.co.uk/isis
A desperate mother has spoken emotionally of how she gave birth to a 'monster' after her daughter fled to Syria from where she is posting web praise for jihadist terrorist killers.
Glamour-conscious Fatima Dzhafarova, 20, lauded her 'brothers' who staged the Paris massacre and downed the Russian tourist jet over Sinai.
This has sparked fury among Russians with her condemned for her 'sick' postings with her branded as 'scum' and 'ISIS whore' with messages telling her to 'burn in hell'.
Scroll down for video
Glamour-conscious Fatima Dzhafarova, 20, lauded her 'brothers' who staged the Paris massacre and downed the Russian tourist jet over Sinai
Her mother has described her pain and difficulty in trying to stop her daughter from leaving to join ISIS - even chaining her daughter to a radiator
Her mother Shakhla Bochkaryova, 41, revealed how she had even chained her daughter to a radiator in the family flat, in a doomed effort to prevent her fleeing to join the jihadists after she became infatuated with an extremist Islamic 'recruiter' who begged her to become his fourth wife.
'I will simply be beside myself if she takes someone else's life,' she said.
'It's better not to live than to be the mother of a terrorist. You realise what a monster you gave birth to.
'It is hard for any mother. Of course, no mother will admit that her child is a monster. But if you're honest, yes, we gave birth to these monsters,' she said.
Her mother Shakhla Bochkaryova, 41, described how Fatima's husband asked her to marry her daughter. Ms Bochkaryova declined his question but Fatima still became his fourth wife
Fatima became infatuated with an extremist Islamic 'recruiter' who begged her to become his fourth wife
Fatima (pictured at her school prom) change dramatically from a lover of fashion to covering her head and not returning her mother's calls
'I will simply be beside myself if she takes someone else's life,' Fatima's mother said
Mrs Bochkareva described her pain at having lost her daughter and the likelihood of never seeing her again
The doomed fate of her daughter comes as reports emerged that an Austrian teenage girl has been beaten to death for trying to flee the brutal jihadi group.
Samra Kesinovic, 17, and her friend Sabina Selimovic became 'poster girls' for ISIS after they arrived in Syria in April 2014.
However details emerged recently suggesting that Samra had been beaten to death for desertion. Sabina is also thought to have been killed in an air strike back in December 2014.
Fatima and her mother had been close as she grew up, her mother revealed, but everything changed when she went to university as a scholarship student in her home city of Surgut in Siberia, and met her 'recruiter', a man known as Abdullah.
Mrs Bochkaryova said she now does not expect to see her eldest child again after she eloped to strife-torn Syria.
'If she lives with a recruiter, she already knows too much,' she said.
'They wouldn't let her leave alive. A bullet, that's the price of her life. As painful as it is, I know I will never see her again.'
Before her obsession with radical Islam, she was a fashionable dresser, said her mother. Fatima grew up in a split home and enjoyed a normal childhood.
Her mother is a non-practicing Muslim and her father and step-father are non-practicing Orthodox but did not practice their faith.
The two Viennese girls, Samra Kesinovic (left), 17, and 16-year-old Sabina Selimovic (right), whose parents are Bosnian refugees, are both thought to have died in Syria. Samra reportedly tried to flee ISIS and was beaten to death
Before her obsession with radical Islam, she was a fashionable dresser, said her mother
Mrs Bochkaryova said she now does not expect to see her eldest child again after she eloped to strife-torn Syria
'She would wear a red coat, short black skirt, and a white shirt,' she told The Siberian Times -
'She always loved office style clothes. She didn't go for low neck, short clothes, jeans, this wasn't what she liked.
'Even to school she'd wear a suit, classic trousers, shirt. She wore make-up and looked after herself. She had a lot of cosmetics, jewellery. She had long hair and took care of it.
'She was very careful about her appearance and always wanted to look good.'
After three months at university, Fatima had changed dramatically. She refused to celebrate Christmas 2014 with her family and tore down the Christmas tree.
Soon she began to cover her head with a headscarf and stopped returning her mother's calls.
Abdullah asked Mrs Bochkaryova for permission to wed his daughter, saying he had three wives and each had three children. She refused.
'He told me he loved Fatima, and she loved him. One of his wives was pregnant when he wanted to marry my daughter,' she said.
In vain she tried to talk to her daughter, and prevent her leaving, even once chaining her to a radiator.
Her mother said Fatima 'always loved office style clothes. She didn't go for low neck, short clothes, jeans, this wasn't what she liked'
The distraught mother said: 'I looked at her and I could no longer see my child. She was simply a shell of my daughter, no soul, no thoughts, no heart'
Fatima and her family are originally from Nizhnesortymskiy, Russia. Fatima now lives in Raqqa, Syria
'She told me: 'Our brothers will come and kill those like you, infidels. They'll cut heads with knives. And you know, my heart won't miss a beat'.'
The distraught mother said: 'I looked at her and I could no longer see my child. She was simply a shell of my daughter, no soul, no thoughts, no heart.'
The FSB secret service confirmed to her that her daughter had fled to Syria, she said.
In postings she praised ''our brothers who shot down the Kogalymavia plane over Sinai' and 'who smashed all in Paris'.
She disparaged the 'kids', 'women', the 'elderly' who had perished, stating: 'We Muslims feel like this every day for years.'
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The Stranger, the Tears, the Photograph, the Touch (Divine presence in Spain and Europe since 1500): a selection of pictures from this forthcoming book is on display in the Hungarian House of Photography – Mai Manó House until May 24.
Book launch on May 4 at 5.30 pm. The book will be presented by Vlad Naumescu, Associate Professor at CEU's Department of Sociology and Social Anthropology.
The latest release is Subversive Stages (Theater in pre- and post-communist Hungary, Romania and Bulgaria).
The Last Superpower Summits was presented on April 11 at the Institute for European, Russian, and Eurasian Studies of The George Washington University.
House of a Thousand Floors is a 2016 INDIES Finalist in the Science Fiction category.
2017 Spring/Summer Catalog is available for download.
Roma-Gypsy Presence in the Polish-Lithuanian Commonwealth, 15th-18th Centuries by Lech Mróz received honorable mention for the Kulczycki Book Prize in Polish Studies.
Top five CEU Press titles by number of copies sold in 2016:
With Their Backs to the Mountains
How They Lived
Post-Communist Mafia State
Arguing it Out
Hybrid Renaissance
Top five by sales revenue in 2016:
With Their Backs to the Mountains
How They Lived
Art Beyond Borders
Nationalizing Empires
Holocaust in Hungary
Andrei Cusco is Director of the Center for Empire Studies at the Department of History and Philosophy within Moldova State University.
Bessarabia―mostly occupied by modern-day republic of Moldova―was the only territory representing an object of rivalry and symbolic competition between the Russian Empire and a fully crystallized nation-state: the Kingdom of Romania. This book is an intellectual prehistory of the Bessarabian problem, focusing on the antagonism of the national and imperial visions of this contested periphery. Through a critical reassessment and revision of the traditional historical narratives, the study argues that Bessarabia was claimed not just by two opposing projects of 'symbolic inclusion,' but also by two alternative and theoretically antagonistic models of political legitimacy.
By transcending the national lens of Bessarabian / Moldovan history and viewing it in the broader Eurasian comparative context, the book responds to the growing tendency in recent historiography to focus on the peripheries in order to better understand the functioning of national and imperial states in the modern era.
420 pages, forthcoming in 2017
978-963-386-159-2 cloth
$65.00 / €60.00 / £52.00


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All hotels in Stockholm, Sweden
1 room, 2 adults
Vasaplan 4, Stockholm, 113 31, Sweden, 800-491-6126
Hotel C Stockholm, Stockholm
For families
- Free toiletries
- Daily housekeeping
- Iron/ironing board
- Hair dryer
- Elevator/lift
- In-room climate control (air conditioning)
See all 1,793 Hotels.com reviews
Room needs to be improved
Great location
Tasty breakfast
More comfort would be nice
TripAdvisor Traveller Rating: 4
From 2,281 reviews
Hotel C Stockholm, Stockholm
Hotel Info: 866-539-8117from $80
- Moderate Queen Room - No Window
- Standard Double Room
- Room, No Windows (Moderate Queen)
- Single Room
- Standard Room
- Superior Double Room
- Deluxe Double Room
- Standard Room
- Standard Twin Room
- Superior Twin Room
- Deluxe Double Room
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At a glance
Key facts
Hotel size
- This hotel has 367 rooms
- This hotel is arranged over 7 floors
- Check-in time starts at 3 PM
- Check-out time is noon
- Express check-out
Nearby Four Star Stockholm hotels
In the hotel
Things to do
- 24-hour fitness facilities
- Bicycle rentals nearby
- Golfing nearby
- Sailing nearby
- Snowmobiling nearby
- Water skiing nearby
Working away
- Business center
- Conference space
- Meeting rooms 11
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Dry cleaning/laundry service
- Free newspapers in lobby
- Luggage storage
- Multilingual staff
- Porter/bellhop
- Number of buildings/towers - 1
- Year Built 2001
- Elevator/lift
- Television in common areas
- In-room accessibility
- Roll-in shower
In the room
Home comforts
- In-room climate control (air conditioning)
- Air conditioning
- Iron/ironing board
Sleep well
- Hypo-allergenic bedding available
- Soundproofed rooms
- Premium bedding
Freshen up
- Free toiletries
- Hair dryer
Stay connected
- Free WiFi
- Daily housekeeping
- In-room safe (laptop compatible)
- Access via exterior corridors
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"Wonderful experience! Visually stunning! The staff was amazing! I can't wait to go back!"Apr 27, 2017
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"We were pleasantly surprised when we reached the hotel to find such friendly staff and a quiet hotel. We were there for relaxation and that is exactly what we got. The staff was…"Apr 25, 2017
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Hotel C Stockholm, Stockholm
Highly recommend
Overall we really enjoyed our stay. We all agreed we would return just for the free breakfast and convenience to the central train station and arlanda express.
Hotel C Stockholm, Stockholm
convenient and clean
Many times you may think of hotels near train stations as cheap or sketchy, but the Nordic C hotel is a classy & comfortable hotel that just happens to be located next to the train station. The location next to the Arlanda Express platform was ideal for getting to the airport early in the morning. Just steps out the door and you are on the train, and then you are at the airport in 20 minutes. The attached restaurant has really great food too!
Hotel C Stockholm, Stockholm
small room but good breakfast
small room but good breakfast
Hotel C Stockholm, Stockholm
Convenient hotel
The room was small but so was the cost. The bathroom and shower facilities or first-rate. It was a little crowded in the room with the bed up against the wall but otherwise was fine.
Hotel C Stockholm, Stockholm
Easy check-in, great breakfast buffet and convenient location
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Trinity Episcopal Church will be hosting a Resurrection forum, Facing Addiction, this Sunday at 11am. T.J. McDowell was a poster boy for clean living: a life guard, camp counselor, and coach...with a hidden drug problem. Come and hear T.J. describe his descent into addiction, and the forces that helped bring him home again. Link in bio for more information. #trinitysolebury #resurrection #addiction #recovery
Trinity Episcopal Church will be hosting a Resurrection forum, JAZZ & JOE, this Sunday at 10:30 a.m. Alan Siegel leads his jazz quintet for a delightful post-service experience of smooth jazz and a celebration of life. During a band break, Alan will describe his recovery from serious brain surgery--despite nearly dying twice during the process. Link in bio for more information. #trinitysolebury #resurrection #jazz'njoe #thejazzsanctuary
Dust off your lobster bibs and kick off summer at Lobsterfest on Saturday, June 3. All proceeds fund Trinity's local, regional and international missions. #trinitysolebury #lobsterfest
Dedicated Trinity parishioners gather to pack 80 meals in support of Aid For Friends, which provides meals to the isolated homebound in Bucks County. #trinitysolebury #aidforfriends #buckscounty
Check out today's Facebook video (link in bio). What will be your fast? What will be your feast? #trinitysolebury #lent #fastandfeast
It's beginning to look and feel like springtime at Trinity #trinitysolebury #spring #springfever #springflowers


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Posts Tagged 'nuclear war'
Christmas Hangover Links!
* An excerpt from the conversation between Tim Morton and Jeff VanderMeer from my and Andy Hageman's issue of Paradoxa is up at LARB. You can read our introduction too! The issue has been printed and will be on its way to subscribers (and available for purchase) soon.
* acting as if nothing terrible has happened
is a failed strategy you yell and this docility
has ruined and crushed us and afraid as I am
I cannot hold your vehemence against you
at this political moment as I watch you dig
your fingers into the rubble you're sitting on
and you say maybe it's impossible to believe
in politeness or civilization anymore…
* Ken Liu's "Paper Menagerie" is the first story to hit the Hugo / Nebula / World Fantasy Award trifecta. Read it!
* What's behind Santa's bloody rise? Three leading elven labor activists offer a class analysis of the North Pole "gift economy."
* The veterans decided that on the day that had once been Christmas Day they would recall their childhood and youth by decorating a tree.
* The Christmas archives: Home Alone! Die Hard!
* Being a parent really is a second childhood: I'm even terrified of nuclear war again. "A tense new battle over nuclear arms erupts between Donald Trump and his staff." Tweeting our way to Armageddon.
* How to Be a Guy: What I Learned My First Year Living as a Guy (at Age 34).
* Carrie Fischer is apparently in stable condition, but George Michael is gone.
* Ted Chiang talks adapting Arrival.
* Blade Runner 2 ("Blade Runnest") and the Koreanization of the future.
* #TheResistance: American Mustache Institute takes a stand against Donald Trump's anti-facial hair bias. John Bolton Vows Not to Shave Moustache.
* Today's purge: Donald Trump is demanding the names of federal employees working to curb violent extremism.
* Trump to inherit more than 100 court vacancies, plans to reshape judiciary. Trump to dissolve Trump Foundation, having moved on to bigger grifts. And why not dissolve the UN while he's at it?
* Reading Fake News, Pakistani Minister Directs Nuclear Threat at Israel.
* Neo-Nazi March Planned for Whitefish, Montana.
* The GOP Theocracy: Xmas vs Hanukkah Statements. And don't worry: RNC: The 'new King' is not Trump.
* Looking back: The collapse of the Obama coalition. What could explain it? More data that couldn't possibly explain it. Having presided over the catastrophic collapse of his party and the possible end of American democracy, Obama gives himself high marks. Why Did Planned Parenthood Supporters Vote Trump?
* 2016 wasn't actually bad, he explained. I'll give it one point, for this.
* We can end the war on milk in our time.
* Prime Minister Dreamboat can't wait to Keystone XL again.
*A consummate bullshit artist, Bucky Fuller's career was built on failure, if not outright fraud. With few of his ideas achieving commercial success, he amounted to nothing more than a hand-waving proponent of outlandish notions. Worse still, he was an aggressive manager of his own profile and patents, an authoritarian technocrat who sought not students but compliant disciples to disseminate his muddled messages. The lynchpin of this view: even the geodesic dome, Fuller's greatest "success," rested on a concept borrowed (to be charitable) from an aspiring student sculptor. Buckminster Fuller in the 21st Century.
* John Williams Hasn't Seen a Single Star Wars Movie.
* More than 54,000 people in the southern German city of Augsburg will have to leave their homes Christmas morning while authorities defuse a giant 1.8-ton aerial bomb from World War II.
* Don't make the joke, don't make the joke: Sex robots will 'come a lot sooner than you think', scientist claims.
* Elsewhere in the rise of the machines.
* A&E Cancels KKK Docuseries Following Criticism. That whole network needs a Truth and Reconciliation Commission.
* BREAKING: All pro sports are bad.
* Actually, my speciality is evil ethics.
* Gasp! Colleges Respond to Racist Incidents as if Their Chief Worry Is Bad PR, Studies Find.
* They did it: They found the worst Star Wars take.
* The arc of history is long, but it can kick over its own head.
* Meanwhile, in Japan: Can the Emperor abdicate?
* And wherever we are on the political spectrum: let's give the giant meteor a chance.
Really Almost Christmas Now Links
* 46 shots that were cut from Rogue One: A Star Wars Story. There Was Almost a Jedi in Rogue One. What Rogue One Teaches Us About the Rebel Alliance's Military Chops.
* How a Pen and Paper RPG Brought 'Star Wars' Back From the Dead.
The Xenofeminist Manifesto, published by the feminist collective Laboria Cuboniks lays out a new framework for technology's role in social progress. "Why is there so little explicit, organized effort to repurpose technologies for progressive gender political ends?" the authors ask. "The real emancipatory potential of technology remains unrealized… the ultimate task lies in engineering technologies to combat unequal access to reproductive and pharmacological tools, environmental cataclysm, economic instability, as well as dangerous forms of unpaid/underpaid labor." This reframing of technology requires a politics that does not shy away from scale and complexity.
* The Strange History of Talossa, a Bedroom That Was Also a Country. Milwaukee's own!
* Indeed, North Carolina does so poorly on the measures of legal framework and voter registration, that on those indicators we rank alongside Iran and Venezuela. When it comes to the integrity of the voting district boundaries no country has ever received as low a score as the 7/100 North Carolina received. North Carolina is not only the worst state in the USA for unfair districting but the worst entity in the world ever analyzed by the Electoral Integrity Project.
* "Even if we darken the sky with hundreds or thousands of satellites and interceptors, there's no way to ensure against a dedicated attack," Montague said in an interview. "So it's an opportunity to waste a prodigious amount of money." This is fine. The
Slim Pickins Trump Doctrine. In 1987, he set out to solve the world's biggest problem. How World War III became possible.
* Today's purge: feminists in the State Department. Yesterday's, of course, was professors teaching courses on whiteness at UW.
* With less than a month to go, Obama is still pretending the presidency is a weak office without much power.
* [fingers crossed] please don't be an academic, please don't be an academic — aw damnit
* Must-read article from 1983: Tuition Hikes in Store at Some State Universities.
* Supercharging the school-to-prison pipeline in Missouri.
* Huge, if true: The CIA Is Not Your Friend.
* In a time without heroes, they were: The Rockettes (2021).
* The law, in its majestic equality… Appeals court vacates 'unconscionable' life sentence for New Orleans man over theft of $15 from 'bait vehicle.'
* The financial system as hostile AI. What can I say? Great minds think alike!
* And friends, I'm here to tell you, it only gets worse from here.
Don't Let Them Know What You're Against or What You're For
* Saturn devours his young: President Trump.
* So weird to see Donald Trump going through all the traditional rituals of assuming the presidency, like the ceremonial settling of your $25 million fraud cases.
* When Mike Pence Went To See Hamilton. (UPDATE: God forbid me, I don't think this is absolutely insignificant.)
* The Problem of Judas in Amos Oz's new novel.
* Film analysis minute: Indiana Jones and the collaborators.
* Dan Berger in Jacobin: This fall's prison strikes are a model of how to both survive and challenge an authoritarian, racist order.
* It starts with accepting a simple fact: the Republican Party nominated a candidate better suited to winning a presidential race in 2016.
* Suicide contagion in the Age of Trump. The Banality of Trump. While You Weren't Looking, Donald Trump Released a Plan to Privatize America's Roads and Bridges. Hey, just out of curiosity, are there any checks in place to keep the US President from starting a nuclear war?
* Let me tell you a story about a major party's nominee for President of the United States.
* I come to you now, at the turn of the tide: Finally, the MLA speaks.
* What the: Minnesota Woman Sues Her Trans Teenager for Transitioning Without Her Consent.
* Pokémon originalism is a thing now.
* What kind of New Jersey accent do you have? What's the most New Jersey thing you can think of?
* Two days after Donald Trump was elected forty-fifth president of the United States, the Canadian government quietly tweaked our immigration system to make it easier for many Americans to move to Canada.
* 75 million years ago, turkeys were 7 feet tall and built for speed. And one day, they'll have their revenge.


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Video Scope
Critter and Guitari Video Scope
The Video Scope video synthesiser produces colorful oscilloscope-style patterns on a television or projector. It displays the waveform of the audio input. It works particularly well with a single sound source like synthesizer, voice, or other instrument, though it will respond to a complete song or similarly complex sound.
The Video Scope has two knobs. One knob controls the input gain, and the other knob selects one of four display modes: Line, Color Shifter, Trapezoid, and Randomizer. The Randomizer function randomly selects one of the other 3 modes at an adjustable rate. This is useful for hands-free operation as the display constantly changes.
- Anodized aluminum enclosure (3.2" x 2.2" x 1.1")
- 1/4" audio input jack
- RCA Composite Video output jack (NTSC only)
- 9VDC wall-wart power adapter included
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However, Ryder's revenues for the quarter rose 7 percent year-over-year, driven by higher fuel costs passed through to customers.
Ships carrying up to 9,800 TEUs can now call terminals west of the Bayonne Bridge without worrying about tidal conditions now that U.S. Coast Guard Sector New York and pilot organizations lifted air draft restrictions.
American Shipper has launched a short survey to collect feedback on how the industry expects to be affected by the new ocean carrier alliances that launched at the beginning of the month.
Registration takes less than 1 minute.
MacroPoint announced its partnership with API provider Banyan, while FourKites unveiled its enhanced integration with supply chain software provider JDA.
The Danish ocean carrier took delivery of the world's largest box ship on Tuesday, the 20,568-TEU Madrid Maersk.
The German ocean carrier is citing benefits from its planned merger with United Arab Shipping Company, but Reuters has reported a "snag" in those plans.