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While hepatocytes rarely undergo proliferation in normal livers, they quickly induce proliferation in response to loss of liver mass by toxin or inflammation-induced hepatocyte injury, trauma, or surgical resection, leading to a restoration of liver mass to its original size. Recent studies suggest that Toll-like receptor (TLR) signaling participates in this regenerative response. Myeloid differentiation factor (MyD88), a common adaptor molecule in the TLR, IL-1 and IL-18 receptor signaling, plays a key role, at least, in the early phase of liver regeneration. Currently, definite ligands which bind to TLRs and initiate this process are still unclear. TLRs stimulated by their corresponding ligands, as well as tumor necrosis factor (TNF) receptors (TNFRs), can activate downstream signal molecules, including transcription factor nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK). Previous studies have revealed the important role of TNF receptor signaling, NF-κB, and JNK in liver regeneration by using hepatocyte-specific gene-modified animals. This review will summarize the current knowledge of TLR signaling and their related molecules in liver regeneration. We will also discuss whether modulating these factors may become new therapeutic strategies to promote liver regeneration in various clinical situations.
The liver is a unique organ that has a great ability to regenerate by itself [1, 2]. After loss of considerable liver mass, orchestrated biological responses are quickly activated to restore the loss of liver mass by hepatocyte regeneration until the liver reaches its original size [1–4]. In this regenerative process, mainly mature hepatocytes proliferate by the stimulation of the regenerative factors released from parenchymal and nonparenchymal liver cells. However, liver failure and massive hepatocyte death (apoptosis and necrosis) in fluminant hepatitis could stimulate liver stem cells (or oval cells), which contribute to liver regeneration [5]. Suppressed proliferative ability in mature hepatocytes caused by hepato-toxin exposures, hepatitis B or C virus infection, or excessive lipid accumulation in alcoholic steatohepatitis (ASH), and nonalcoholic steatohepatitis (NASH), also induces the activation of liver stem cells leading to liver regeneration [5]. Because liver injuries induced by inflammation or ischemia/reperfusion and their relation to toll-like receptors (TLRs) are being discussed elsewhere in this issue, we will focus on the role of TLR signaling in liver regeneration after partial hepatectomy (PH), which is a pure hepatic regeneration model. We will further discuss the potential role of TLRs and subsequent signaling pathways that activate nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK) in liver regeneration.
Among a number of biological responses after PH, a group of genes, so called immediate-early genes, are quickly induced [6, 7], which lead to the transition of cell cycle from G0 to G1 in hepatocytes. In contrast, some group of genes are upregulated during the entire period of regenerative responses [8, 9]. Meanwhile, importance of several proinflammatory cytokines including tumor necrosis factor (TNF)-α and interleukin (IL)-6 in liver regeneration has been debated during the last decade [2–4]. It is now accepted that these cytokines play significant roles in the priming and early stage of liver regeneration after PH. Although expression of TNF-α and IL-6 is upregulated 1hr after PH, activation of transcription factor NF-κB and AP-1 and expression of immediate-early genes, including c-jun, c-fos, and c-myc, are upregulated within 30min after PH [7]. These findings suggest that PH induces very quick biological responses, which lead to activation of NF-κB and AP-1, and expression of immediate-early genes. On the other hand, quick upregulation of urokinase-type plasminogen activator (u-PA) and uPA receptor (uPAR) is induced in response to PH [10], implying significant roles in the interaction between u-PA and uPAR in the priming phase of liver regeneration. u-PA also activates several growth factors, including hepatocyte growth factor (HGF) and ligands for epithelial growth factor receptor (EGFR), which induce strong regenerative responses in the liver [11].
Many investigators have proposed that gut microflora-derived lipopolysaccharide (LPS) might trigger the initiation of liver regeneration [12–14]. Upon PH, gut-derived LPS might activate nonparenchymal liver cells, particularly Kupffer cells, in which NF-κB is activated. Then, activated Kupffer cells release regenerative cytokines, such as TNF-α and IL-6. IL-6 activates STAT3, resulting in the initiation of liver regeneration after PH [2]. After the discovery of TLRs, gut-derived lipopolysaccharide (LPS), a ligand for TLR4, was reconsidered as a trigger of the initiation of liver regeneration [15, 16].
Toll-like receptors (TLRs) were originally identified as homologs of Drosophila Toll that regulates dorsoventral embryonic polarity and antifungal immunity [17]. TLRs facilitate innate immune responses for the host defense against microorganisms by recognizing pathogen-associated molecular patterns (PAMPs) [18]. In addition, endogenous components derived from dying host cells, termed damage-associated molecular patterns (DAMPs), can bind and activate TLRs [19, 20]. After the stimulation with corresponding ligands, TLRs relay signals via myeloid differentiation factor (MyD) 88, a common signal adaptor molecule shared by the receptor for IL-1 and IL-18, and all members of TLRs except for TLR3 [18]. This signal transduction leads to activation of NF-κB and results in the production of various proinflammatory cytokines, including TNF-α and IL-6. The MyD88-dependent pathway also activates p38 and c-Jun N-terminal kinase (JNK) as well. The TLR/MyD88-mediated biological events are reminiscent of those observations in liver regeneration after PH. We and others have investigated the role of TLR/MyD88-mediated signal transduction in liver regeneration after PH [15, 16]. Both studies demonstrated that in MyD88-deficient mice, induction of immediate-early genes, including c-fos, c-jun, JunB, and c-myc, was greatly diminished [15], and NF-κB activation in Kupffer cells was also subnormal after PH. Production of IL-6 and TNF-α and phosphorylation of STAT-3 were completely suppressed in MyD88-deficient mice after PH [15, 16]. However, these studies showed contradictory roles of MyD88 in the regenerative response of hepatocytes after PH. DNA synthesis in hepatocytes significantly delayed in the early phase of liver regeneration in our investigation [15] implies the significant role of MyD88-dependent signaling in the early and priming phase of liver regeneration. Meanwhile, the MyD88-deficient mice showed no delay in hepatocyte replication in the other report [16]. To discuss this discrepancy, we might consider the breeding condition of animals in different institutions. Recent reports demonstrated that mice from different animal suppliers have different composition of microflora in the intestine [21]. In addition, MyD88-deficient mice are more sensitive to changes in the composition of microflora [22]. Here, we propose that there is a large contribution of intestinal microflora-derived components, as the ligands for TLRs, to liver regeneration after PH. The differences in the composition of gut microflora might lead to the different regenerative responses between different institutions. Nowadays, the concept that TNFα, IL-6, and NF-κB are crucial for PH-mediated liver regeneration is still supported by many investigators. Thus, we confidently propose the concept that the MyD88-dependent regenerative response after PH is important for initiating the priming of liver regeneration. Nevertheless, liver mass was finally restored in MyD88-deficient mice compared to WT mice even in our experiment, suggesting that MyD88-independent compensatory regenerative processes also contribute to liver regeneration.
Another interesting finding is that the intact liver regeneration is induced in TLR2−/−, TLR4−/− [16], TLR2−/− TLR4−/−, and TLR9−/− mice [15] after PH. This result suggests that the gut-derived LPS and its receptor TLR4 do not play a major role in triggering the priming phase of liver regeneration. In addition, both IL-1 and IL-18 receptor signalings also use MyD88 as a signal adaptor molecule [23]. Therefore, possible contribution of IL-1 and IL-18 to the priming of liver regeneration should be considered. However, Caspase-1−/− mice, which lack the capacity to convert proform of IL-1β and IL-18 to active form [24, 25], exhibit normal liver regeneration after PH, suggesting minor roles of IL-1β and IL-18 in liver regeneration [15]. What is the crucial trigger of the MyD88-dependent biological events in the priming of liver regeneration? We propose that various gut microflora-derived components and/or unidentified endogenous ligands for TLRs activate multiple TLRs including TLR2, 4, 5, and 9 that lead to triggering the priming of liver regeneration after PH. Further investigation is required for proving this hypothesis.
The studies by others and us suggest that TLR/MyD88 signaling participates in the process of liver regeneration, especially in the early and priming phase, after PH. However, definite TLR ligands responsible for the priming process are still unknown. Further investigations are required for addressing this issue. Notably, LPS injection suppresses liver regeneration after PH, indicating that excessive TLR signaling inhibits this regenerative process [26]. Thus, the TLR signaling has double-edge sword-like functions in liver regeneration, and an appropriate magnitude of TLR signaling is required for intact liver regeneration.
On the other hand, TLR3 utilizes another adaptor molecule, TRIF (TIR domain-containing adaptor-inducing interferon-β). Recently, the role of TLR3 signaling in liver regeneration has been reported [27]. In TLR3−/− mice, initiation of liver regeneration is shifted to the earlier time point, suggesting that TLR3 signaling inhibits the initiation of liver regeneration. This inhibitory effect of TLR3 signaling is also supported by a previous report that activation of TLR3 by injection of its ligand, polyinosinic-polycytidylic acid (poly (I:C)), suppressed liver regeneration after PH [28]. Interestingly, NF-κB activation in hepatocytes was significantly suppressed up to 10hrs, but its activation was relatively prominent in Kupffer cells in TLR3−/− mice after PH. These findings suggest that after PH, unknown ligands, probably endogenous ligands for TLR3, activate NF-κB through Rip1 in hepatocytes that inhibit hepatocyte replication.
Other components of the innate immune system, complements including C3 and C5, have been reported to participate in liver regeneration after PH [29]. C3- or C5-deficient mice exhibited high mortality, liver parenchymal cell damage, and impaired liver regeneration after PH. NF-κB activation was markedly reduced at 1hr after PH in C3-deficient mice. Thus, the complement system plays a significant role in the priming phase as well as in the subsequent proliferative phase during liver regeneration.
NF-κB is an essential transcription factor for maintaining liver homeostasis, including cell survival and death [30]. As NF-κB p65 whole body knockout mice cause the embryonic death due to an extensive hepatocyte apoptosis, NF-κB plays a crucial role in preventing hepatocyte apoptosis during liver development [31].
A very quick increase in NF-κB DNA binding activity after PH has been reported in early 1990s [32, 33]. We are the first demonstrating the role of NF-κB in liver regeneration after PH. We introduced IκB α superrepressor, a potent NF-κB inhibitor, by adenoviral vectors (Ad-IκBsr) to inhibit NF-κB activation in the liver [34]. In this study, the rat livers introducing superrepressor of IκB α (IκBsr) demonstrated the prominent hepatocyte apoptosis and blunted early increase in NF-κB DNA binding activity in hepatocytes during the initial 24hrs after PH, suggesting antiapoptotic role of NF-κB in hepatocytes after PH. Liver regeneration was significantly impaired in this study. A similar experiment employing Ad-IκBsr in mice was reported by Yang et al. [35]. In this paper, overexpression of IκBsr in mouse livers also inhibited liver regeneration after PH but did not induce hepatocyte apoptosis. Discrepancy between these reports might be due to different infectious abilities against adenoviral vectors between rats and mice. This might induce hepatocyte apoptosis only in rats. Since TNFα is produced in the early period after PH, this discrepancy also might be due to different sensitivity to TNFα-induced cell death between rats and mice. Thus, activation of NF-κB in hepatocytes is important as an antiapoptotic factor, at least in rats, but not in mice after PH.
A subsequent study further reported the specific role of hepatocyte NF-κB in liver regeneration after PH [36]. Transgenic mice expressing a hepatocyte-specific mutant IκBα exhibited the normal regenerative response and did not show hepatocyte apoptosis after PH. TNFα treatment induced prominent apoptosis in these animals. A use of adenoviral vector in our study, indeed, possibly made the issue complicated because adenoviral vectors could infect not only hepatocytes, but also nonparenchymal liver cells including Kupffer cells. In the study by Maeda et al. [37] to inhibit NF-κB activation, IKKβ (inhibitor of kappaB kinase β, also known as IKK2) was inactivated in both hepatocytes and hematopoietic-derived cells (Kupffer cells) by conditional knockout technique using Mx-1 Cre transgenic mice. These mice reduced the proliferative response after PH. Taken together, these findings suggest that NF-κB activation in Kupffer cells is more important than that in hepatocytes.
In a recent study [38], the modulation of hepatocyte NF-κB activity by inactivation of IKKβ demonstrated the controversial results from the studies by Maeda et al., [37], Yang et al., [35], and us [34]. Hepatocyte-specific IKKβ knockout mice showed that accelerated hepatocyte proliferation and early NF-κB activation in nonparenchymal liver cells including Kupffer cells were observed. In contrast, a weak and delayed NF-κB activation in hepatocytes was seen after PH, suggesting that this IKK and NF-κB activation in hepatocytes might be through IKKα. These findings further suggest that IKKα in hepatocytes is crucial in liver regeneration after PH. Addressing this issue, further investigation is needed. JNK activation in hepatocyte-specific IKKβ knockout mice is prolonged in the liver after PH [38]. Because Cyclin D is a JNK/AP-1 target gene, a strong and sustained JNK activation could be involved in the accelerated liver regeneration by inducing Cyclin D expression in hepatocyte-specific IKKβ knockout mice. This study also examined pharmacological inhibition of IKKβ, which enables to inhibit IKKβ activity in both hepatocytes and nonparenchymal cells. This treatment had little effect on the regenerative process [38], which corroborates the results from Chaisson et al. [36], but it does not support the results from Maeda et al., Yang et al., and us; NF-κB in Kupffer cells is critical in liver regeneration.
The crosstalk between NF-κB and JNK in the liver after PH has been demonstrated in the study using Gadd45β (growth arrest and DNA-damage-inducible gene 45β), an NF-κB target gene, knockout mice [39]. Gadd45β−/− mice exhibited decreased hepatocyte proliferation and increased programmed cell death during liver regeneration, in which JNK activity was increased and sustained. This study further supports the concept that an appropriate activation of NF-κB in hepatocytes is important for liver regeneration by regulating JNK activity through Gadd45β. This issue will be discussed below.
It is now almost acceptable that the activation of NF-κB in Kupffer cells is crucial for intact liver regeneration after PH, especially for the priming phase [3]. Activated NF-κB conducts sequential production of TNFα and IL-6, each of which plays a significant role in the priming phase of the regenerative process. Indeed, early activation of NF-κB in liver regeneration after PH was demonstrated to primarily occur in Kupffer cells using cis-NF-κB-EGFP transgenic mice [35]. Moreover, inactivation of NF-κB in Kupffer cells as well as in hepatocytes impaired the proliferative response after PH as mentioned above [37].
Prompt expression of c-jun and activation of c-Jun N-terminal kinase (JNK) have been reported after PH as described above [40, 41]. Fetuses lacking c-jun die at midgestation with defects in heart morphogenesis and increased apoptosis of both hepatoblasts and hematopoietic cells in the fetal liver [42, 43]. Moreover, mice lacking the JNK kinase SEK1 exhibit a liver defect similar to c-jun−/− fetus [44, 45]. Roles of the transcription factor AP-1 (activator protein-1), including c-Jun, as a regulator of cell survival and death are well summarized in a previous paper [46]. The function of c-Jun at later stages of liver development or in adult liver remained to be elucidated.
The role of c-jun during liver regeneration after PH was first reported by using floxed c-jun alle (c-junf) mice crossing with Alfp-cre or Mx-cre transgenic mice [47]. In either Alfp-cre or Mx-cre-induced conditional c-jun knockout mice, prominent hepatocyte death and lipid accumulation in hepatocytes were observed after PH. These mice exhibited high mortality and impaired liver regeneration. These results indicate that c-jun is required for hepatocytes regeneration after PH. Interestingly, c-Jun N-terminal phosphorylation is not required for c-Jun function in liver regenerative response [47].
Important roles of JNK activation after PH have been reported [48]. Inhibition of JNK activity in the liver using a small molecule JNK inhibitor (SP600125) resulted in reduced c-Jun phosphorylation and AP-1 DNA binding activity. JNK inhibition suppressed cyclin D1 expression and delayed hepatocyte proliferation after PH, resulting in decreased survival but not hepatocyte apoptosis. This implied that JNK drives the transition of cell cycle from G0 to G1 transition in hepatocytes and that cyclin D1 is a crucial target gene of the JNK pathway in liver regeneration. However, these results were different from the data obtained from the study in which c-jun was genetically inactivated [47]. Potential explanation for this discrepancy is that JNK mediates its effects on liver regeneration after PH through other targets such as ATF2 or JunD [48]. As mentioned above, c-Jun N-terminal phosphorylation is not required for regeneration after PH [47], suggesting that increased JNK activity after PH has other significant roles rather than its ability to phosphorylate c-Jun N-terminal. Two isoforms of JNK are expressed in the liver; JNK1 and JNK2 [49, 50]. Distinct functions in these JNKs have been reported [51]. Namely, JNK1 induces cell proliferation with c-Jun phosphorylation. In contrast, JNK2 suppresses proliferation by degradation of c-Jun. Sabapathy and Wagner also reported an acceleration of liver regeneration in JNK2−/− mice in their perspective [52].
HGF and EGFR-ligands activate JNK. Mice expressing an inducible Met mutation by Mx-cre system in the liver showed blunted c-jun phosphorylation around 48h after PH and a great suppression of Erk1/2 phosphorylation during the entire regeneration process [53]. Hepatocyte-specific EGFR deletion resulted in reduced cyclin D1 expression and delayed hepatocyte proliferation after PH. Surprisingly, this observation was accompanied by sustained activation of c-Jun and reduced NF-κB DNA binding activity [54]. This prolonged c-Jun activation after PH in the hepatocyte-specific EGFR-deleted mice might be independent of EGFR-mediated JNK activation, or there might be unknown negative regulatory mechanism on JNK/c-Jun activation in the EGFR signaling cascade. Nevertheless, it is suggested that prolonged activation of c-Jun inhibits liver regeneration after PH. Prolonged activation of JNK after PH has also been observed in Gadd45β−/− mice as mentioned above [39]. Why does prolonged JNK activation suppress liver regeneration after PH? Notably, a genetical ablation of JNK2 prevents impaired liver regeneration and increased hepatocyte cell death in Gadd45β−/− mice after PH. Although it is obvious that JNK pathway directly induces cyclin D1 upregulation to contribute to hepatocyte proliferation [39], however, prolonged JNK activation hampers liver regeneration after PH, at least, by enhancing programmed cell death.
TGF-β-activated kinase (TAK)-1 is a crucial component for activating both NF-κB and JNK. An adenoviral overexpression of dominant negative in the liver accelerated the proliferative response after PH [55]. This might be explained by the inhibitory role of IKKβ and JNK2 in liver regeneration in previous studies [38, 52]. An appropriate crosstalk between JNK and NF-κB is critical for intact liver regeneration after PH. An opposing role of NF-κB and JNK in hepatocarcinogenesis has been proposed. Loss of NF-κB activity in hepatocytes increases the sensitivity to hepatocarcinogenesis with increased JNK activation [37, 56–58] while JNK1 knockout mice exhibit decreased carcinogenesis after N-nitrosodiethylamine administration [59]. The mutual crosstalk between the NF-κB and JNK has been well documented in the previous reviews [60, 61].
In summary, the transient upregulation of the two downstream targets NF-κB and JNK in TLR/MyD88 and TNFR signaling is strictly organized in Kupffer cells and hepatocytes upon PH, which leads to normal liver regeneration (Figure 1).
Understanding the mechanism of liver regeneration is important for managing several clinical conditions, such as acute liver failure and impaired hepatic functions after liver transplantation. An issue concerning small-for-size grafts in liver transplantation is a well-known clinical subject. An experiment using small-for-size graft in rats revealed that suppressed AP-1 DNA binding activity and reduced cyclin D1 expression resulted in impaired liver regeneration. This was attenuated by administration of a radical scavenger [62]. Impaired liver regeneration in patients with NASH (nonalcoholic steatohepatitis) or NAFLD (nonalcoholic fatty liver disease) is also a major clinical issue. Animal experiments revealed that impaired liver regeneration with suppressed NF-κB DNA binding activity and delayed and prolonged c-jun expression after PH in ob/ob mice [63]. Microarray analysis in the patient livers with NASH revealed that mRNA expression of transcription factors such as v-Jun (oncogenic isoform of c-Jun) was significantly suppressed compared with nonobese control patients even without liver resection [64]. However, the most critical issue in clinical situation is impaired liver regeneration in patients with advanced liver fibrosis. A number of factors including deposition of excessive amount of extracellular matrix, existence of continuous inflammation, transformation of sinusoidal endothelial cells and hepatic stellate cells, and decreased portal blood flow may affect the regenerative ability in the fibrotic livers. In addition, increased JNK activity, as observed in animal models during fibrogenesis [65], may also account for the impaired regenerative process in these patients.
The ligands for TLRs are a strong candidate for triggering the initiation of liver regeneration. However, discovery of the real trigger which initiates liver regeneration is a challenging assignment for hepatologists because multiple ligands and multiple TLRs could contribute to this process. In addition, understanding of the interaction between the two major transcription factors; NF-κB and AP-1 (such as c-Jun), and the regulation of JNK activity by NF-κB seems to be critical to elucidate the well-orchestrated process. Further investigation of distinct roles between these factors in hepatocytes and nonparenchymal cells should be required employing cell-specific gene manipulation techniques. The management of the impaired balance between these factors in nonparenchymal cells and hepatocytes may provide insight into developing new strategies for inappropriate hepatic regenerative response in patients with chronic and acute liver diseases.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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They framed a face,
That exhibited quite some grace.
Proof that sometimes size DOES matter…(This cartoon is now available as a greeting card in my shop at Etsy.)
Completed in 193o, the Chrysler building is considered a leading example of Art Deco architecture. The terraced steel crown makes this landmark a true gem in Manhattan's skyline, and I never tire of photographing it.
Here are just a few of the photographs I've taken of this magnificent building…
Filed under architecture, My Favorite Things, New York, New York City


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Near the complex of the famous Humayun's Tomb in New Delhi, there's another mausoleum, whose architecture is strikingly different from its popular neighbour. It is that of Isa Khan Niazi, a Pashtun courtesan in Sher Shah Suri's durbar, who fought against the Mughal empire.
Tag / HDR
Wat Benchamabophit
Show the picture some love on yourshot.nationalgeographic.com
The Wat Benchamabophit Dusitvanaram, also known as the Marble Temple, is one of the most beautiful temples we saw on our visit to Bangkok.
A little bit o' Fortune
The Namdroling Monastery, near Bylakuppe in Coorg, Karnataka, India in the largest teaching center of Nyingmapa – a lineage of Tibetan Buddhism in the world.


text: ×Close Product Image 1 of 1 Scarecrow and the Nightingale See image Scarecrow and the Nightingale By William Joyce Illustrated by: Moonbot × Added to Cart List Price $17.99 Your Cart ( items) Cart total Continue Shopping CHECKOUT NOW Choose a format: Hardcover eBook Choose a format: Hardcover Hardcover eBook Atheneum/Caitlyn Dlouhy Books | 56 pages | ISBN 9781442473539 | October 2018 List Price $17.99 Ships on or around October 30, 2018 Browse Related Books Children's Fiction > General Pre-order now from another retailer Amazon Barnes & Noble Books-a-Million IndieBound Walmart Video William Joyce discusses The Guardians of Childhood "A fabulous recapturing of an old, real fairytale world. Dark. Mysterious. Stunning!" --MAURICE SENDAK, Caldecott-winning creator of WHERE THE WILD THINGS ARE Link: http://www.simonandschuster.com/videos/William-Joyce-discusses-The-Guardians-of/syq5uMGHWq30 Get a FREE eBook when you join our mailing list. Plus, receive updates on new releases, recommended reads and more from Simon & Schuster. Email Address Free eBook available to NEW subscribers only. Offer redeemable at Simon & Schuster's ebook fulfillment partner.Offer expires in three months, unless otherwise indicated.See full terms and conditions and this month's choices. More Books from this Author William Joyce William Joyce Moonbot Ollie's Odyssey Ollie's Odyssey By William JoyceBy William Joyce Bently & Egg Bently & Egg By William JoyceBy William Joyce Jack Frost Jack Frost By William JoyceBy William Joyce Billy's Booger Billy's Booger By William Joyce and MoonbotBy William Joyce and Moonbot See more by William Joyce Billy's Booger Billy's Booger By William Joyce and MoonbotBy William Joyce and Moonbot A Bean, a Stalk and a Boy Named Jack A Bean, a Stalk and a Boy Named Jack By William Joyce and MoonbotBy William Joyce and Moonbot About the Author photograph (c) Tony Reans William Joyce William Joyce does a lot of stuff but children's books are his true bailiwick (The Numberlys, The Man in the Moon, Dinosaur Bob, George Shrinks, and the #1 New York Times bestselling The Fantastic Flying Books of Mr. Morris Lessmore, which is also his Academy Award–winning short film, to name a few). He lives in Shreveport, Louisiana. Talk to William Joyce and look at upcoming work at @HeyBillJoyce on Twitter and Instagram. BECOME A FAN BOOKSVIDEOSAPPEARANCES


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President Donald Trump seems destined to serve his 100th day in office without House passage of a major Republican health care bill or enactment of a budget financing the government for the rest of this year. But at least the government probably won't be shut down - for at least another week.
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Consumers hoping to consistently find out how many calories are in that burger and fries may have to wait - again. New government rules to help people find out how many calories are in their restaurant meals are set to go into effect next week after years of delays.
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Employers can legally pay women less than men for the same work based on differences in the workers' previous salaries, a federal appeals court ruled Thursday. The decision by the 9th U.S. Circuit Court of Appeals overturned a lower-court ruling that said pay differences based exclusively on prior salaries were discriminatory under the federal Equal Pay Act.
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In this Feb. 21, 2017, file photo, Environmental Protection Agency Administrator Scott Pruitt speaks to employees of the EPA in Washington. Sen. Sheldon Whitehouse filed an ethics complaint on April 25 against EPA Administrator Scott Pruitt over a planned May 5 appearance as the keynote speaker at the Oklahoma Republican Party's annual gala dinner.
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President Trump's former national security adviser, Michael Flynn, was warned by authorities when he retired from the military in 2014 not to take foreign government-sourced money without "advance approval" from the Pentagon, according to documents released Thursday by the ranking Democrat on a House oversight committee. Flynn, a former U.S. Army lieutenant general and Defense Intelligence Agency chief, was later paid tens of thousands of dollars for his work on behalf of foreign interests, including Russia's state-sponsored RT television network and a Turkish-owned company linked to Turkey's government.
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Moore, who was the suspended Chief Justice of the Alabama Supreme Court, said he filed ... . Suspended Alabama Chief Justice Roy Moore announces his plan to run for U.S. Senate during a news conference Wednesday, April 26, 2017, on the steps of the Capitol in Montgomery, Ala.
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During his 100 days in office, Donald Trump has come to rely on a select group of close advisers and aides, both in a professional and a personal capacity. Here are some of those with a direct line to the president.
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With British governments often accused of being too hung up on the so-called special relationship with Washington, the fact then US president-elect Donald Trump rang a slew of other leaders before Theresa May following his shock election triumph served as a wake-up call for Downing Street. Accused of taking a Hillary Clinton victory for granted and failing to forge links with the firebrand Republican standard bearer for the White House, Number 10 scrambled to try and build bridges.
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Millions of naturalized citizens could be at risk for providing false statements under the Justice Department's interpretation of a federal law, but the Supreme Court appeared dubious. Lose citizenship for fibbing? Supreme Court justices fume Millions of naturalized citizens could be at risk for providing false statements under the Justice Department's interpretation of a federal law, but the Supreme Court appeared dubious.
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LeachCo Organic Smart Cuddle-U Original Nursing Pillow
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- Seat wrap prevents wiggling and sliding out as it supports and cuddles baby
- A newborn essential for that cuddle me feeling
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About this item
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- A newborn essential for that cuddle me feeling.
- Overall Height - Top to Bottom: -7.5 Inches.
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To participate in Queensland Child Protection Week, the following Grants and Award nomination options are available:
Regional Grants
Regional Grants of $3,000 (including GST) are available for each of the six regional areas of Queensland. The regions are:
- Far North Queensland
- North Queensland
- Central Queensland
- North Coast
- South East
- South West
Funding submissions must reflect collaboration with a minimum of five other agencies within the region. To be eligible for funding your submission must respond to the selection criteria for the Regional Grants. The funding application form contains further details.
Regional Grant Applications must be received by close of business 20 May 2016
Complete the online Regional Grants Form
Activity Grants
Grants of up to $1000 (inclusive of GST) are available to non-government organisations, community organisations and networks. Successful applicants may receive full or partial grants. The Queensland Child Protection Week Committee encourages applications for events that have been designed to positively support the theme and aims of Child Protection Week.
Thus your local activity will:
- promote the theme Protecting children is everybodys business
- promote our Key Messages
- provide people with an opportunity for ongoing involvement in helping prevent abuse and neglect
- Where possible, link participants to a broad range of information, resources and services already available through government and non-government organisations.
Activity Grant Applications must be received by close of business 20 May 2016
Complete the online Activity Grants Form
Award Nominations:
The annual Queensland Child Protection Awards provide an opportunity to publicly acknowledge the efforts, commitment and unreserved energy of many people who make a significant contribution to our community to prevent child harm and neglect.
It is hoped the awards will inspire others to continue to work towards ensuring the wellbeing of our children.
Awards are presented to individuals or groups in the following categories:
- Professional (Non-government) Outstanding contribution to promoting child protection issues in their capacity as a professional working in the child protection (or related) field.
- Professional (Government) Outstanding contribution to child protection at a practice, policy or service development level within the public service.
- Volunteer Invaluable contributions to child protection made by volunteers working in government or non-government agencies.
- Regional Program A program that operates within part of, or across, a region to address some aspect of child protection.
- Education Initiative Development of an innovative approach, research or resource to promote child protection.
- Youth Participation Involvement of young people in the planning of a local activity to promote child protection.
- Media & Communications An article, news story, series, publication, campaign or communications strategy that demonstrates a significant contribution to highlighting child protection issues.
- Community Initiative Any community operated program, initiative, event or campaign that focuses on enhancing child protection in our communities.
- Addressing overrepresentation of Aboriginal and Torres Strait Islander families, children and young people in the child protection system Outstanding contribution to addressing the overrepresentation of Aboriginal and Torres Strait Islander families, children and young people through policy, programs or practice.
NOMINATIONS must be received by close of business 1st June 2016
Complete the 2016 Nomination Form
Should you require any further information please go to www.childprotectionweek.com.au or contact Caitlin King


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With the Centre and the Supreme Court locked in a tussle over the new Memorandum of Procedure for the appointment of judges, P P Choudhary's position as MoS Law assumes significance. A first-time MP from Pali in Rajasthan and a senior Supreme Court lawyer, Choudhary was part of the Joint Committee of Parliament that looked into the contentious land acquisition Bill brought in by the NDA and which was later abandoned.
MANEESH CHHIBBER: Tell us about your journey from being a senior lawyer to becoming a Union minister in the NDA government.
I have been in the legal profession for the past 38 years. I am a first-timer in politics. I was inspired by the call of Narendra Modi ji to provide clean and transparent governance for the betterment of the country. It was then that I decided to take a plunge into politics. I got a ticket to contest from Pali in Rajasthan and I won by over four lakh votes. As an MP, I participated in over 350 debates in Parliament, sought the response of the government through 394 questions and submitted 22 private member Bills for consideration. If I had to sum up my politics in one line, then I would say that I felt suffocated by what I saw at the lower level. It is painful, and that was one reason why I decided to enter politics. Now, when I see my colleagues in Parliament, I feel good.
MANEESH CHHIBBER: People think the judiciary and the government are in confrontation. Is that a correct perception?
I think this perception is absolutely incorrect. Our government can never think of weakening the judiciary. The common man of the country reposes immense faith in the justice delivery system to redress his grievances. Hence the credibility and independence of the judiciary are of paramount importance. Our duty is towards strengthening the independence and credibility of the judiciary, and the NDA government under the leadership of Prime Minister Modi has been making extensive efforts in this direction. But, sometimes, remarks are made. I believe that one constitutional functionary should not be accusatory towards another, be it the government, the judiciary or Parliament. While the executive speaks through its orders and actions, legislature speaks through the enactment of laws, the judiciary speaks through its judgments. Hence, it is these judgments which should be given due weightage.
MANEESH CHHIBBER: Is there a communication gap between the government and the judiciary?
I don't think such a communication gap exists. However, I feel that there is always scope for improvement. One of the ways forward could be to hold periodic meetings between the government and judiciary at the highest levels.
MANEESH CHHIBBER: But then why are so many appointments stuck?
I have a list (of appointments) till November 15, 2016. Till date, four judges have been appointed to the Supreme Court, 124 additional judges have been made permanent and 120 fresh appointments of judges have been made in various high courts. We have not received names for the seven vacancies in the Supreme Court. The sanctioned strength of the judges of high court has also been increased from 906 in June 2014 to 1,079 judges as on November 25, 2016. This data speaks for itself. I don't need to draw a conclusion. Right from Independence till date, so many appointments have never been made in 8-10 months. And if you still say appointments have not happened, it will be contrary to the data I have provided.
MANEESH CHHIBBER: So why does the government want more power over appointments in higher judiciary?
It's not a case of government seeking more power in the appointments of higher judiciary. Were appointments made before the collegium system better or worse? I can name several judges who passed judgments that are still recalled and followed. The Constitution prescribes a collaborative process in the appointments, where both the executive and judiciary have been entrusted with clearly demarcated roles and responsibilities. The government has always given significant weightage to the judiciary's recommendations.
With regard to the collegium system and the existing Memorandum of Procedure (MoP), the Supreme Court has, in its December 16, 2015, judgment, acknowledged the need 'to introduce transparency in the matter of appointment of judges to the higher judiciary'. This is not our verdict or opinion. It is felt that the present collegium system is not equipped with an efficient mechanism to objectively evaluate the competence of candidates in a holistic manner. Hence, I feel that both the executive and judiciary must work in a coordinated manner through an extensive process of consultation for appointment of judges.
MANEESH CHHIBBER: Now that the government has sent the revised draft of the MoP to the SC, where is it stuck and why is it not getting finalised?
Acting as per the directions of the Supreme Court on December 16, 2015, the government initiated the process of drafting the revised MoP. After passing through several rounds of consultations with the SC, the latest draft MoP, which is in consonance with the court's judgment of December 16, 2015, was sent on August 3, 2016, for the consideration of the Supreme Court collegium. It may take more time and deliberations must be on for sure. Both (the judiciary and the executive) have the same aim, though the means might be different. Both the government and the Supreme Court collegium want more objective considerations and fewer subjective considerations in the procedure (of appointments). Personally I feel that apart from finalising the revised MoP, the original spirit of the Constitution needs to be restored in the appointments of the judges of the Supreme Court and high courts by defining the word 'consultation' under Article 366. In my personal opinion, there should not be any insistence on making any further appointments as per the old MoP. This shall be against the true spirit of the December 16, 2015, judgment of the Supreme Court.
SHEELA BHATT: But won't judges know better than the government about judges and the quality of judgments?
The appointment of judges has been made a collaborative and consultative process between the judiciary and the executive, so that both can pool their resources together to select the best candidate for the job. I do agree that the judicial competence of a judge or a practising lawyer can be best gauged by the judiciary. But the collegium system is flawed and the SC itself said so; this is not the government's observation. The appointments are not without flaws. Appointment of a judge to higher judiciary requires a holistic assessment of the qualities of the candidate which go much beyond judicial competence. Here, it needs to be noted that one of the reasons for the increase in vacancies in the higher judiciary, despite recommendations by high courts, is that the collegium rejects, on an average, 30 per cent of recommendations made by the high court collegium. On matters of national security, the government holds the wherewithal to evaluate any threat, and any input or opinion given with respect to national security by the government needs to be given due weightage.
UNNI RAJEN SHANKER: You said that if the government raises issues of national security, it should be put on record and the SC should not be asking questions. How is that transparent? Two, the names of 43 judges have been rejected by the government. How was it linked to national security?
First of all, no person can claim the right of appointment. The SC can only insist that you should appoint such and such person. But because this is a constitutional post, this involves national security. As I said earlier, apart from judicial competence, the government is well-equipped to assist the judiciary in a holistic evaluation of the candidates. Articles 124 and 217 of the Constitution signify the role of the executive in the appointment of judges. If the government finds that an appointment goes against national security or overrides public interest, then such an appointment can be declined by the government and reasons for the same can be shared with the Chief Justice of India. Thus, there is complete transparency in the process.
MANEESH CHHIBBER: The Centre's stand on triple talaq and Uniform Civil Code has led to an uproar. Are you playing vote-bank politics?
As far as the issue of Uniform Civil Code is concerned, it is enshrined in Article 44 of the Constitution as one of the Directive Principles. The matter is currently being examined by the Law Commission and once it submits its report, the government will examine it. As far as the issue of triple talaq is concerned, it needs to be remembered that personal laws must be examined in the light of the overarching goals of gender justice and dignity of women. The underlying idea behind the preservation of personal laws was the preservation of plurality and diversity among the people of India. The need for preservation of such diverse identities cannot be a pretext for denying women the status and gender equality they are entitled to under the Constitution. Even Muslim countries, where Islam is the State religion, have undergone reform in this area of the law. In a secular republic like India, there is no reason to deny women their rights.
VANDITA MISHRA: You said you are a first-time MP who became a minister too. That's unusual in politics, especially if you don't have political clout or backing. How difficult was it for you to join politics?
I would not say that this is unusual. There are several people in Parliament who are first-time MPs and who have become ministers. Our prime minister is also a first-time MP. The NDA is against dynasty politics and every person is accorded a role in the organisation and government based on governance requirements. Getting a ticket to contest elections wasn't difficult. After that, I held 600 meetings in 17 days.
VANDITA MISHRA: You said you felt suffocated by what you saw at the lower level of politics. What is it that you found most suffocating?
The suffocation I spoke about earlier was with reference to corruption in the country. When I entered politics and saw that elections involve a lot of money and that there is a lot of corruption at the lower levels, I was disappointed. In Modiji's government, there is no corruption, there are no allegations against the government or its ministers. This is in complete contrast to what used to happen in the past, when 2G and several other scams were reported. There has been status quo in the bottom rung for the last 60 years, so yes, it will take time, but we will clean up the system. The root cause of corruption is the existence of a parallel economy which generates black money in the country. Through the unprecedented move of demonetisation, the Prime Minister has initiated the process of weeding out the malice of corruption. Demonetisation has shaken certain people who operate with money and muscle power. Modiji has the support of the aam aadmi in this campaign. Now if a political party asks its cadre to destabilise things, it's another issue altogether. But for the genuine people — the salaried ones, who always pay their taxes — it is a welcome step.
NANDAGOPAL RAJAN: The use of social media is expanding but there are no laws to govern it. Do you think we need laws to govern the medium?
If your question is related to cyber security, as Minister of State for Electronics & IT, I can assure you that this issue is of immense significance for us. As a medium, Internet is a truly democratic global platform which provides individuals with an opportunity to express themselves and also serves to bridge the digital divide. However, this freedom should not cause harm or undermine the rights of other individuals. Within the fold of the ministry, institutions such as CERT-in are taking proactive measures to ensure that the public as well as private data is well protected. As far as the issue of prevalence of laws governing social media is concerned, there is no law governing the behaviour of individuals in cyber space. However, whenever the behaviour of an individual in cyber space affects the rights of other individuals, the Information Technology Act prescribes the nature of the crimes as well as the quantum of punishments attached to such crimes, to safeguard such rights.
MANEESH CHHIBBER: After the recent ICANN conference, where it was decided that the US government is set to cede control of the cyberspace's underlying technology, you had said that may be some of these servers and master servers could be in India too.
On October 1, 2016, the US had transferred its stewardship role in ICANN's IANA (Internet Assigned Numbers Authority) to a multi-stakeholder community . Ten of the root servers in the world are located in the US, while the other three are located in Sweden, the Netherlands and Japan. India is a country known for its strengths in the field of providing quality IT and ITeS services to the world. Our software professionals are working all over the world, with a majority in the US and Europe. Thus there is a case for a new root server to be located in India. Besides this, we have also taken the matter of Indian representation in the ICANN board, as India has around 450 million active Internet users at present. Half of the next billion Internet users would be from India. This would provide India a role in the international Internet governance, and democratise such international governance institutions further. They have to take a decision.
SHYAMLAL YADAV: There is a perception that this government is against RTI. What does your experience say? Is RTI a problem for the administration or is it a solution and a tool for good governance?
The RTI Act was enacted by Parliament and not by a court order. The government made it a law. It felt that the government should be transparent and its procedures, except confidential documents, should be known to the common man. The government is not at all uncomfortable with it. The government can never be uncomfortable with a law enacted by Parliament.
MANEESH CHHIBBER: You filed a number of PILs while you practised in courts. In the past few years, it has been said that PILs are being misused. Do you think it's time to regulate PILs?
There can be no hard and fast rule. It differs from case to case. I think the courts will have to decide which PIL to entertain and which not to look at. If the PIL brings to the court's notice a violation of fundamental rights, or if it is about poor people who cannot approach the court by themselves, then I think courts should entertain them. But if the court feels that a particular PIL is politically motivated, frivolous, filed to build someone's political image or has an ulterior or oblique motive, then the court should disallow it. While I am not in favour of a one-size-fits-all regulatory structure for regulating PILs in the country, I believe that there is a need for creating robust checks and balances, including initiating penal actions against any kind of PILs which are politically motivated.
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- Nov 27, 2016 at 10:16 am43 candidates selected by High Court CJ and other judges in the high court are security threat? ( and I believe the list and records and back ground checks go thru CJI and other judges in the collegium in the Supreme court) Did they ALL overrule the security report and why and how? If they are not showing their reasons (of overruling) - are not they themselves security threat? What kind of arguments are these?Reply
- Nov 27, 2016 at 12:35 amVery educative, constructive and appreciable interview. Thanks to PM for selecting such qualified and matured persons for Minister post.Reply
- Nov 27, 2016 at 4:15 pmBJP govt wants yes men and chamchas as judges . If some of the judges are found against national interest by I B then terminate them but it is very bad and sad that without any proof denying promotion is against all sort of norms . If govt relies on only IB report then let them select all the judges of high/supreme courts.Reply
- Nov 27, 2016 at 3:27 amThe question is law suit takes 10 years and that must change .courts should be functioning 6 days a week from 8 to 6 PM and all the vacancies should be filled and more courts should be opened . There is no shortage of judges and lawyers . There shoul not be continuation and verdict should be swift and implement it right a way.Reply
- Nov 27, 2016 at 6:01 amSome of my family members say I m anti national . Thanks to the ministree . Now these some people will say judiciary is also anti national . I feel shameful for my people electing such ideological people who say judiciary anti national . I totally believe judiciary is an autonomous body and gatekeeper of consution . Sabha cannot withhold it's appointees for long time . U know there is lakshman rekha which no autonomy should cross regarding other , to prevail forced injection towards autonomy .Reply
- Nov 27, 2016 at 4:45 amIs Government sharing IB reports with CJI. If no Government has no right to punish likely appointees based on IB report which may be of political liking but may not be objective reportingReply
- Nov 27, 2016 at 12:11 pmOn my PIL NO 625 of 2016 ,SC took up one of the issues ie shortage of judicial officers. In my PIL I had given some practical and implementable suggestions for elimination of over 3 crore cases pending in courts. I humbly suggest that SC and GOVT should consider these for earliest implementation to provide relief to a very large number of litigants.I feel with this ,additional judicial officers may not be neededReply
- Nov 28, 2016 at 1:06 amIt is one of the best interviews, I had gone through yet. Specially initiative towards commissioning of root server in India will strengthen IT sector and will improvise quality services.Resulting good governance, but still lot of efforts require to improvise cyber law, and it's effective execution within genuine time frame.Good luck,keep it continueReply
- Nov 27, 2016 at 8:28 am37% of the elected MPs and MLAs in the country have criminal cases against them. Modi is silent on this issue of national importance and is anti national to that extent.Reply
- Nov 27, 2016 at 4:16 amWhat he is saying is that any adverse reference or Judgement against the Govt shall be deemed antiNational anad against National security.lt;br/gt;lt;br/gt;All this is a direct result of Public having lost it completely.lt;br/gt;lt;br/gt;People are saying acha kiya,do they know that all this Money will only end up in Banks lending it at throw away rates in condition were the Economy has shrunk to end up as bad debts.lt;br/gt;lt;br/gt;Do they know that Govt has written off 125000 crores lend by PSU Bnaks and that includes 1800 cr given to Malaya.lt;br/gt;lt;br/gt;Do the Public understand that making 500 and 1000 bucks non tenders they have reduced demand and will directly effect jobs and job security.lt;br/gt;lt;br/gt;Do the Public know that Re will weaken and recession is inevitable.lt;br/gt;lt;br/gt;Just as this Minister has said that anything that is against National security will be ignored.lt;br/gt;lt;br/gt;The Govt has now distanced itself from the demonitisation.lt;br/gt;lt;br/gt;If the RBI did it,then why did Modi claim he did SUrgical strike and caught all corrupt Netas unaware.lt;br/gt;lt;br/gt;Modi is running with the harea and hunting with the houndsReply
- Nov 26, 2016 at 11:20 pmNo surprise at all.lt;br/gt;lt;br/gt;Let the Judges to be know what is expected of themReply
- Nov 27, 2016 at 3:19 amWhat National security.????lt;br/gt;lt;br/gt;BJP was out of power for 100 years - people elected you all to power via the same consution and gave the same power. You are servants of people and consution.lt;br/gt;lt;br/gt;BJP should learn to be humble and serve the people.Reply
- Nov 27, 2016 at 4:09 amJudges have to be Desh Bhakts as per RSS defination.Reply
- Nov 27, 2016 at 5:22 amIs the MOS Law is trying to suggest that the collegium is recommending names of anti national, people for appointment of HC Judges.Reply
- Nov 27, 2016 at 6:49 amBottom line is government is elected by people, Elected leaders makes laws and makes appointments including judges it is their power. If people find it unacceptable, they will change the government. Judiciary's role limited to interpreting the laws made and check if they are in conformity with consution and any amendments, that according to the law..Reply
- Nov 27, 2016 at 4:40 amLike always BJP is logical. Those illogical people who were ruining the country for last 70 years shall be weeded out of Indian politics forever.Reply
- Nov 27, 2016 at 6:14 amIf any one is a threat to national security then government is justified in rejecting his name for the post of a judge. But will government explain if such person is legally proceeded against by it on the basis of its information. If not, it is only a hoax to stall the appointment.Reply
- Nov 27, 2016 at 2:39 amIf Government has enough evidence against a Judge, then why doesn't it file a case against them ?Reply
- Nov 27, 2016 at 3:52 amThey will destroy democracy and freedom. Then we'll realize how precious these things are.Reply
- Nov 27, 2016 at 2:27 amChoudhary sounds like a learned and sensible person, I am glad he is in the government.Reply
- Nov 27, 2016 at 7:05 amThe MoS did not reply to the pointed question as to the whether the 43 judges who have been rejected by the government where linked to national security? If the Govt was tansparent, as it is claiming to be, the grounds for rejection should have been made public. We know how transparently they had handled the Gopal Subramanium case. ertions are being dispensed as facts with the threat that these be accepted at face value.Reply
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2 Timoteo 3:15-16Nueva Versión Internacional (NVI)
15 Desde tu niñez conoces las Sagradas Escrituras, que pueden darte la sabiduría necesaria para la salvación mediante la fe en Cristo Jesús. 16 Toda la Escritura es inspirada por Dios y útil para enseñar, para reprender, para corregir y para instruir en la justicia,
Nueva Versión Internacional (NVI)
La Santa Biblia, Nueva Versión Internacional® NVI® Copyright © 1986, 1999, 2015 by Biblica, Inc.® Used by permission. All rights reserved worldwide.
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Welcome to the end of the world4.43 / 5.00 5,376 Views
Living Dolls: No Evil 024
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sweet series
was i the only one hearing every few lines, or was that common thing
The battle between Protoman and Shadow Man was intense (especially when Protoman threw a shuriken at Shadow Man in midair)! You should put in a full voice cast like in parts 2 and 3. When's part 5 coming out?
i thought this died but then i find this. good stuff as always. too bad about the voice actors thou. half the time they suck anyways and/or flake out
Truly amazing.
Dude, the entirety of your Mega Man flash movies have been extremely awesome. It'll be great to see how all of this ends. I love the concept you have of the filler between the Original Mega Man Series and the X one. I'll be waiting for the 5th one. 5/5


text:
'Fixed & Dance.Here.Too Present Ellen Allien'
That disorientation you feel upon hearing "Flashy Flashy," Ellen Allien's creepy-crawly-cool new single? That's the way all of Dust feels. Don't adjust the vertical hold: Allien, Bpitch Control controller and Berlin techno vet, has been shuttling confidently between relative light (Orchestra of Bubbles, the 2006 split with Apparat) and consuming, sewer-drip tech weirdness (2008's Sool) for a decade. Her new material is another neon feather in her cap; stylish like something not quite understood, a good bet for this gig would be to wear that jumpsuit you just fashioned in the basement. With Fixed operatives JDH and Dave P.
Sat., May 29, 10 p.m., 2010
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Singing Out!
Acting Out UK
Deadline: 02 May 2017 at 13:00
Learn the techniques of singing in a fun, relaxed environment with expert tutor Jennifer Lau and Acting Out UK. Exams & Performances available too!
Edinburgh City
Acting Out Drama School
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Train with top Directors and Coaches while gaining a Trinity College Edinburgh certified ATCL Diploma (English equivalent to HND in Scotland). Course starts October 2017
Edinburgh City
Public Speaking Course
Acting Out UK Drama School
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Improve your confidence and public speaking ability. Suitable training for those who have presentations, co-operate events, meetings at work, interviews and even wedding/special occasion speeches.
Edinburgh City
Acting Out Drama School
Deadline: 02 May 2017 at 12:00
For those who wish to practice acting a little more seriously, with a sprinkle of fun and in-depth acting rolled into one course.
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Creative Europe Desk UK-Scotland
Deadline: 27 September 2017 at 23:55
Find out about upcoming deadlines for Creative Europe supported Training and Networking opportunities for film, TV and video game professionals.
Clovenstone Primary Photos
Clovenstone Primary School
Deadline: 07 May 2017 at 18:00
Photographer required for August 2017 to take individual photos of each pupil (approx. 275) and photos of each class.
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Lead Technician
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Deadline: 29 May 2017 at 15:30
The aim of this post will be to play a hands on role, maintaining pace and standards within a small fabrication team working across casting, digital machining, metal fabrication and carpentry.
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Claytime! - Mid Century inspired Vase
Dundee Ceramics Workshop
Deadline: 25 May 2017 at 18:00
This Claytime! session will focus on slab building to create a mid-century inspired vase. Lead by designer/maker Steph Liddle, we'll focus on minimal shapes and forms to create a graphic vase.
Angus and 3 other locations.
Claytime! Ceramic Mobiles and Wall Hangings
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Deadline: 11 May 2017 at 18:00
Inspired by the kinetic sculptures of Alexander Calder, this Claytime! session will focus on minimal shapes and forms to create a contemporary and graphic ceramic mobile or wall hanging.
Angus and 3 other locations.
Claytime! Coiled Bowls
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Deadline: 27 April 2017 at 18:00
This Claytime! session will explore coiling techniques to create bowls. Lead by artist Rosemary Head, this versatile hand-building technique is a great skill for any clay lover to learn.
Angus and 3 other locations.
(Fashion) Office Admin and Production Assistant
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We are looking for an organised, flexible and enthusiastic person with an interest in textiles and fashion. Strong industry awareness is essential. Previous administration experience desirable.
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Horizons Discount WOMEX Registration
Horizons @ WOMEX 2017
Deadline: 23 June 2017 at 17:00
Horizons is an initiative to collectively promote the music of the nations of the UK & Ireland at WOMEX. Discount WOMEX Registration now open until June 23rd 2017
All Scotland, England, Wales, Northern Ireland, International
Wasps Studios is Recruiting
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Wasps Studios is recruiting for three new positions to better support our tenant network, improve our existing estate and to take forward a series of new development projects to expand our network.
All Scotland
Throw Up 20.18
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As we turn 30, Toonspeak are bringing together their extended family, and are inviting new friends to join us for a day of reflection and development.
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Intro to Mindfulness and Creative Mindfulness
Forth Valley Creative Learning
Deadline: 15 May 2017 at 17:00
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