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Privat rom
Plass til
Bonfim, Porto, Portugal
L'appartamento è piccolo ma graziosissimo, con tutto il necessario per due persone. Situato a pochi minuti a piedi dalla metro (3 fermate per raggiungere il centro), permette in alternativa di raggiungere le principali attrattive in 10-15 minuti di cammino. Quartiere popolare, affascinante ed autentico.Roberta2016-10-24T00:00:00Z
Carlos and his brother Bruno made us feel very welcome in Portugal! Carlos already gave tips even days before we arrived. Bruno handed over the keys and took care of our bags after our rental period. The apartment is really new and very clean. Walkable distance (10min) to the city center. Comfortable bed. Good kitchen. Recommended!Jon2016-10-31T00:00:00Z
Our flight was delayed and we arrived very late at night but Carlos was great and was waiting for us by the metro station to take us to the apartment. He showed us everything we needed to know and was a lovely guy. We loved the apartment.Camilla2016-09-28T00:00:00Z
Le logement correspond en tout point à la description : très propre, refait à neuf et la décoration très sympa ! Idéalement situé : à environ 15 minutes à pied du centre-ville et à deux pas de la station de métro «Heroismo» (qui dessert la ligne de l'aéroport) Carlos est trés disponible et serviable et nous le remercions vivement pour son accueil !Brigitte2016-10-16T00:00:00Z
Carlos was very friendly, (found us looking around lost as we exited the Metro, which goes very conveniently straight from the airport to his street) and showed us a few areas on a map which he provided.Judith2016-10-10T00:00:00Z
We had a lovely stay in Carlos's clean and tidy apartment. Great location to stay as it's only walking distance into town. We didn't use the tube once other than the easy metro journey from the airport. He was very helpful by giving us information and recommendations of the local area. We also mentioned before our visit that we were looking to book plans for New Years and he even sorted all that before our stay which was lovely. Thank you Carlos!Hannah2017-01-05T00:00:00Z
Todo perfecto, era tal cual la descripción, hermoso el departamento. La ubicación mejor imposibleGeorgina2016-09-28T00:00:00Z
O Carlos foi muito prestável e disponibilizou-se para ajudar no que fosse preciso. Da minha parte não foi necessário nenhuma informação sobre a cidade, visto que já conheço bem o Porto. O apartamento estava impecável, limpo e tinha as comodidades básicas.Andreia2016-09-24T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
Muy recomendable: un piso limpio y cómodo a 10min andando del centro de la ciudad, con conexión directa en metro al aeropuerto (un puntazo) y todo lo que necesitas cerca (súper mercado por ejemplo). Tiene terraza, lo que se agradece. Puedes usar la cocina, completamente equipada... joana nos lo puso fácil e hizo que la estancia sea agradable.sophie2016-07-31T00:00:00Z
Joanas place is clean, well equipped, and a short walk from the center of the city. Joana was lovely to stay with!Christopher2016-10-15T00:00:00Z
I had an amazing time at Joana's place! Joana is a lovely host, who is very welcoming, funny and takes the trouble to make you feel at home. The room is spacious and the bed is big and comfy - I slept very well in it :-). The shower is fab: a big rain shower with nice warm water. The apartment was very clean and in a perfect location: I was able to walk everywhere in the city without any problem, but it's nice and quiet during the night, so you get the best of both! I highly recommend this place! Thanks again for the good care Joana!Iris2016-04-15T00:00:00Z
Good location, really nice host!Santi2015-09-22T00:00:00Z
Joana's place was a very nice one to start our journey in Portugal. She is a great host, very friendly and helpful with insider advice you'll never get anywhere else (just ask about the cat paradise...). Thanks for a good time!Hanna2016-04-05T00:00:00Z
A estadia foi muito agradável e o quarto era confortável e espaçoso. A Joana foi bastante simpática, compreensiva e flexível com os horários. Recomendo! (João)Leonor2015-10-16T00:00:00Z
Lovely, super clean room on a quiet street, a short walk from anything you might want to do in Porto. The awesome shower gets bonus points! Thanks Joana for staying up late to let me in !!Becky2016-06-06T00:00:00Z
Joana is really friendly and easy going. She was really helpfull to give us few adresses to visit Porto. Her flat is really nice and tidy. On top of that, it's 5 minutes walk from city center.David2016-08-11T00:00:00Z
Privat rom
Plass til
Porto, Porto, Portugal
Casa sporca, piena di polvere, cacca di gatto in camera, non una mappa, non una indicazione. Esperienza pessima. Anche se avevo affittato la stanza per diversi giorni, dopo il primo ho cercato altro e ho cambiato. Per chi volesse contattarmi sarò lieto di indirizzarlo da Carlos, un ragazzo molto gentile e simpatico.giorgio2016-09-20T00:00:00Z
Antonio was a very nice gentleman and communicated everything very well even though his english is not very good but he was using an app to translate. He allowed me to use his kitchen space and fridge etc. and was very helpful.Osman2016-08-13T00:00:00Z
Antonio fue encantador.Flexible con todo y me dejó la casa a mi disposición.Pablo2016-07-15T00:00:00Z
I spent 7 days in the house of Antonio and I can say that it is an excellent offer .Antonio is a delectable host trying to help in all things. His flat has a very good location , is very clean and you have everything what you need. Therefore,it remains for me nothing more than higly recommend this place. Antonio, OBRIGADO!!!zibi2016-08-31T00:00:00Z
Delt rom
Plass til
Bonfim , Porto, Portugal
Eugenia and Carlos were the perfect hosts! They took their time to recommend things to see in Porto and places to eat. The apartment is modern and beautiful with a lovely interior. The street outside is busy but the windows are well isolated. The location was perfect, right next to a quiet square to have breakfast on a sunny terrasse. I really recommend this Airbnb flat.Sandra2015-07-24T00:00:00Z
We had a great time in Porto thanks to Eugenia and Carlos. The unit was clean and spacious and they provided many suggestions for things to do during our stay. Would definitely recommend!Melissa2015-09-04T00:00:00Z
The flat was perfect. It was very clean and had everything we needed for a short stay in Porto. It was easy to find a short walk from the metro. We were met by Eugenia who showed us around the apartment and gave us good recommendations of things to do and places to eat. There was port chocolates bread and coffee left in the apartment which we appreciated. The flat was in an ideal situation and we could walk easily into the centre to visit all the sights. The apartment was beautifully presented and Eugenia was very helpful.heather2016-04-11T00:00:00Z
A bright welcoming despite our late arrival : Eugenia and Carlos gave us a lot a cool informations. The apartment is perfecly located, and a great place to take reste after long hours walking up and down the streets of Porto ! Thanks a lot. Bernard & SabineBernard2016-04-18T00:00:00Z
We had a wonderful time in Porto and Eugenia and Carlos are very helpful and nice hosts. Their restaurant recommendations were superb! The apartment is ideally located within walking distance to many attractions, markets, restaurants etc. The apartment itself was extremely clean and well organized and everything worked. It was well stocked with spices, cleaners and such and they even left us some fresh bread, jams, port and chocolate! The off street parking was a huge help! I highly recommend this apartment in Porto!Maureen2016-04-20T00:00:00Z
Apartamento muy acogedor limpio y nuevo. Muy cerca del centro vas andando a todos los sitios. Eugenio y su marido encantadores. RepetiremosIosu2016-03-30T00:00:00Z
Nos hôtes avaient tout préparé pour nous accueillir avec plein de renseignements pratiques pour visiter Porto. Le logement est très bien situé pour éviter de prendre la voiture ( garée dans leur garage privé) et se rendre aussi bien dans la ville que de l'autre côté du Douro.Nadine2016-07-29T00:00:00Z
Eugenia nos recibió a la hora acordada y nos trató de maravilla, nos recomendó lugares y nos dio mucha info. El apto esta bien ubicado y muy bien equipado, recomendable 100%guillermo2015-06-13T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto-distriktet, Portugal
Petit appartement agréable, très proche du métro. Rue agréable avec des petits troquets très accueillants!Margot2017-01-21T00:00:00Z
Week end de 3 jours à Porto pour decouvrir la ville. Très bon accueil, studio moderne, propre, très bien décoré et à 2 pas de la station de métro. Du balcon, très belle vue sur une jolie église. A recommander :)Benjamin2016-12-06T00:00:00Z
Excelente T0, renovado, muito limpo e bem decorado. Óptima relação qualidade-preço. Muito próximo do Metro e da Estação de Campanhã. O Bruno foi um anfitrião muito simpático e disponível. Recomendamos a qualquer casal de visita ao Porto!!!Carolina2017-01-01T00:00:00Z
We had a wonderful stay here in Porto, the apartment was very clean, cosy (just like in the pictures :) ) and you even have a very nice view from the balcony :) But the most important thing is that we are really glad we had such a caring and helpful host! When our flight got cancelled he helped us a lot and we could stay another night at another of his beautiful apartments. Thank you so much for everything, Bruno!Imke2017-03-08T00:00:00Z
Não tenho palavras para descrever o studio e o atendimento do Bruno. Simplesmente fantástico, o Bruno extremamente educado, atencioso, disposto e gentil. E o apartamento uma graça, limpo, organizado, exatamente igual as fotos! Com certeza voltarei, obrigada por tudo!Letícia2017-03-29T00:00:00Z
logement correspondant a l annonce . tres fonctionnel et parfait pour une visite de porto de quelque jours . thanks Brunojulien2017-03-03T00:00:00Z
Alojamiento justo delante del metro. El apartamento es cómodo, limpio y muy nuevo. El apartamiento tiene todo lo que puedes necesitar. Bruno atento y agradable. Al no tener calefacción hemos dejado un calefactor todo el día puesto, pero ha sido suficiente. Si volvemos repetiríamos.Ariadna2017-01-15T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
Good placeMatteo2016-12-11T00:00:00Z
Bon rapport qualité/prixThuy Linh2017-03-15T00:00:00Z
Muy cómodo y totalmente equipado, situado en un barrio tranquilo cerca del centro y de la parada del metro, perfecto para descubrir Oporto. La información y recomendaciones sobre la ciudad nos resultaron de lo más útil. Sin duda 100% recomendable.Oriol2017-02-12T00:00:00Z
La casa de María está muy cerca del centro y de la parada de metro, es muy fácil llegar desde el aeropuerto. Nos recibió su marido y en todo momento estuvo dispuesto a ayudarnos con cualquier duda o problema. La casa está impecable, y es muy acogedora. Sin duda una muy buena opción para pasar unas noches en la ciudad. El barrio también es muy tranquilo y silencioso.Carlos2016-11-23T00:00:00Z
Moderne, raffiné et impeccable. Intimité préservée grâce à l'accès independant. Propriétaire disponible et fort sympathique.Christophe2016-11-27T00:00:00Z
Appartement parfait autant au niveau de la situation géographique que de la propreté et de la décoration. Tout est réellement parfait. C'est l'excellence même. On ne peut pas trouver mieux. L'accueil de Maria est à l'image de l'appartement. Chaleureux, aimable, accessible, parfait. Grand merci Maria pour votre accueil. Merci pour tout. À très bientôt.Mathilde2016-11-15T00:00:00Z
Todo perfecto!Cris2016-11-22T00:00:00Z
Facilidad en todo momento para comunicarse con ella.Cecilia2016-12-03T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
We had a perfect stay at Andreia's spacious apartment. We especially loved being able to sit outside in the small yard in the morning (with only the slightly scary woman upstairs as a kind of remote company). The metro is right down the street, and we found all our daily shopping needs were met by stores within 100 yards. The area itself may not be that interesting, but it doesn't take more than 20 minutes to walk into the center of Porto.Joachim2016-07-12T00:00:00Z
We had a wonderful stay in the apartment of Andreia. Andreia is an excellent host. She was there to welcome us when we arrived at the apartment and really took the time to give us some great suggestions for places to eat and things to see in Porto. The apartment is beautiful decorated. The neighbourhood is fine and city centre is in walking distance. Would definitely recommend staying here!Sarah2017-02-20T00:00:00Z
Ottima posizione a due minuti dalla metro. Tranquilla anche se la stanza da letto è piano strada.Quartiere tranquillo e pieno di supermercati e alcuni ristoranti, tra cui uno vegetariano quasi di fronte casafrancesco2016-12-29T00:00:00Z
Nous avons passé du bon temps comme chez soi dans l'appartement d'Andreia, particulièrement bien décoré. C'est un appartement chaleureux avec une terrasse pour se délasser le soir ou prendre le petit déjeuner le matin par beau temps. Nous avons apprécié toutes les adresses que nous a laissées Andreia pour se restaurer, visiter, aller à la mer et manger des sardines... Merci Andreia !!!Anne2017-03-04T00:00:00Z
Andrea tiene una casa muy cómoda y bonita. Es una gran anfitriona y muy comprensible con mis peticiones. Nos dió muchas recomendaciones. Todo muy limpio y muy bonito decorado. Muy recomendableMaria2017-03-20T00:00:00Z
Appartement totalement conforme aux photos voire encore mieux en vrai. Celui-ci est très confortable et de nombreuses petites attentions attendent les hôtes (à vous de venir les découvrir sur place). La terrasse ombragée permet de se reposer au calme après la visite de la ville. Excellent accueil très attentionné et en français de la part des parents d'Andreia qui était en vacances lors de notre séjour mais cependant très disponible. La situation de l'appartement permet de rejoindre le centre sans avoir besoin de moyen de transport et est proche de petits commerces et de supermarchés sans être dans un quartier touristique. L'appartement était équipé du wifi et également d'un boitier 4G/wifi qui peut être emmené à l'extérieur pour partager la connexion avec les équipements multimédia.Cyril2016-07-23T00:00:00Z
Andrea and her husband Santiago were great host. Very helpful and wanted to make sure we got the best of Porto. The home is cozy and quiet. All the beds were pretty comfortable. There is only one bathroom with small shower with very little hot water. Other then that everything else was perfect. The location is pretty close walking distance to most places. We loved Porto and would definitely come back and also stay in Andreas cozy loft.Michelle2016-05-21T00:00:00Z
Great stay! We really enjoyed Porto and this apartment. Tiago & Andreia had some great tips which we really liked.Timothy2016-09-30T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
Nice confortable house, one the 3rd Floor, without elevator. A little off-center, but still central. Easy parking. Quiet area. The toilet could use some improvements.Valter2017-03-05T00:00:00Z
Everything was perfect, place, house...CECILIA2017-02-20T00:00:00Z
We really enjoyed our stay at Mauricio's place. Very reasonable price, clean and good location. I'd definitely recommend!Shakiba2016-12-29T00:00:00Z
Localização muito boa, excelente local para casais. Os únicos problemas que encontrei é que não tinha forno e a internet caia muito!!!Carlos Ernesto2017-04-06T00:00:00Z
Simple, but well equipped. Nothing more and nothing less than what you need to feel at home on a short stay!Ilana2017-03-23T00:00:00Z
El anfitrión muy pendiente de nuestra llegada y solicitudes aunque no le conocimos. Relación calidad-precio bastante buena. Gracias Mauricio por tu hospitalidad.Johanna2017-01-05T00:00:00Z
Pros : - location is quite good, 10 mins walk from downtown/Ponte Luis I. - the price ! awesome price for what we get - clean room - towel for use Cons : - this is a shared-flat with 5 other rooms occupied by travelers also. Therefore, your experience will get impacted by the others travelers! - the only con is that the kitchen was not clean because the other roomies didn't clean their stuffs and tools ... So if another person wants to use it, they have to clean instead of them Overall, very good stay, I highly recommend. Would come back.Thibaut2017-03-19T00:00:00Z
It was really comfartable and clean place. I feel like living at home..Batuhan2016-10-02T00:00:00Z
Privat rom
Plass til
Porto, Porto, Portugal
Beau studio très agréable, les hôtes sont charmants.Jaelle2016-06-22T00:00:00Z
Joana and her husband were very kind. The apartment is great, it has everything you need, a very big bathroom and a great modern shower! I will definitely reccomend it. Thank you again Joana!Rosa2016-06-07T00:00:00Z
Carlos the joana's husband let me directly informations before our arrival for us to know where were the best restaurants, bars and things to see. He answered directly our questions and we felt more than welcome when we arrived at the flat (I let you discover!). One of the best hosts I have never had with airbnb. I recommand!arnaud2016-11-15T00:00:00Z
Joana was very nice and friendly. The studio is just perfect!!Elisa2016-08-23T00:00:00Z
Great location, nice flat, helpful and friendly owners!:)Adomas2016-07-19T00:00:00Z
The studio was really comfortable, spacious and clean. It is located very well and we could reach everthing on foot. Although we didn't saw Joana in person, the arrival was without any problems. Only the hallway of the building smelled a little odd which unfortunately spreaded a bit into the studio. But apart from that it is very recommendable!Jessica2016-08-27T00:00:00Z
Très agréable séjour dans l'appartement de Joana. Logement spacieux (plus qu'il n'y paraît sur les photos) propre et tout neuf. Situé proche du centre facilement accessible à pied. Joana et son mari nous on accueillis chaleureusement malgré notre arrivée tardive. Ravie pour une première expérience sur Airbnb.Charlène2016-07-28T00:00:00Z
Great place, kind and communicative people!! Highly recommendAna2016-12-08T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
Privat rom
Plass til
Porto, Porto, Portugal
Júlinha nos trató muy bien,es muy agradable y buena anfitriona, nos ayudó en todo lo que necesitamos, incluso nos preparó un bote de caramelos. La habitación está bien y la cama es buena, el baño limpio aunque huelen un poco las tuberías. La cocina con todo lo necesario, limpia y recogida. La situación es perfecta y tener donde meter el coche es genial ya que todo Porto es zona de pago. Ideal para pasar dos o tres días.David2016-01-06T00:00:00Z
The apartment is good located and very central. Júlinha shared her home with us for one night and she was very hospitable! The private car park is great, but we were lucky, there were also some free parking spots on the street.Caro2016-03-10T00:00:00Z
I had a lovely stay with Júlinha! The room was comfortable and clean, the location of Júlinha's apartment is very central and close to the old town! Júlinha herself was a very sweet host who made sure I was comfortable and gave me great tips about Porto! Thanks Júlinha for a great stay!!Robin2016-09-04T00:00:00Z
A casa é limpa, confortável e perto do centro. A proprietária foi gentil e tudo correu-se muito bem.Francesco2015-12-08T00:00:00Z
the room was exactly as shown in the phone, in a quiet neighbour hood close to the metro with a lovely balcony. Although we arrived late around 1 am, Julinha stayed late to greet us which I appreciate a lot.Kelly2016-06-13T00:00:00Z
Tres bon accueil chez Julinha... on se sent comme chez soi! L'appartement est super bien situé a coté du marché et proche du centre ville. Tout pour passer un super séjour à Porto.marine2016-11-06T00:00:00Z
logement bien situe,nous avons aime l'accueil chaleureux et attentionne de Julinha!B2016-08-03T00:00:00Z
Todo fue perfecto, cerca del centro, muy bien comunicado con el aeropuerto y muy simpática y servicial, sin duda una anfitriona a recomendar.José Luis2016-02-14T00:00:00Z
Privat rom
Plass til
Porto, Porto-distriktet, Portugal
Obrigada Floriza e Luis a recepção foi optima. Adoramos a casa e a localização. Muito limpa e com todos os bens essenciais disponíveis. Bastante acolhedora e bem localizada. Vamos recomendar e voltaremos!Catarina2016-02-13T00:00:00Z
Appartement bien placé proche du métro (moins de 10 min à pied), Resto proche sympa et supérette bien pratique juste à côté. Par contre la literie manque de confort.Matthieu2017-02-13T00:00:00Z
Floriza's apartment is lovely; everything you would need for a short break away. The tea, coffee and biscuits were a very nice homely touch. We are keen walkers so the 15 minute walk into the centre of town didn't trouble us too much. There is a metro station very close by which was useful too. We had a very enjoyable stay in Porto, thank you, Floriza!Rose2012-07-06T00:00:00Z
Apartment is exactly as it looks like in the pictures, modern, cozy and clean. The flat is in the Marques neighborhood, which is not in the heart of the old city but only 2-3 stations away from central Porto. Floriza was friendly and easygoing. Overall, great value for money spent!Berti2012-12-22T00:00:00Z
My husband and I stayed three nights at Floriza's flat in Porto. The flat was easy to find with sat-nav, and we initially chose this particular apartment because there was a garage opposite to safely leave our rental car during our stay. The flat was very comfortable and we would have been happy to stay longer; it was well equipped, extremely quiet, and as other reviews have stated, only a few minutes from a small supermarket and about 5 minutes to the metro station. Having an elevator to take us to the second floor was a bonus! Floriza left two metro/bus Andante transport cards (like the London Oyster card) which we loaded with 6 journeys each. It was not expensive. There was a transport staff member to assist us, but there is a translation into several languages at the ticket machine. Whilst staying there we were able to get into the city centre near the river very quickly and overall the apartment could not have been in a better location for us. Two days was not long enough to visit Porto, so we will be back, and will have no hesitation in booking again at Casa Alegria.Ann Clarissa2013-11-02T00:00:00Z
Bom apartamento, zona central, wifi grátis e a vantagem de garagem grátis à porta de casa, uma vantagem grande quando se trata do centro da cidade. Extremamente limpo e a roupa de cama e casa de banho a cheirar a lavado, com um perfume muito agradável. O apartamento tem alguns problemas de climatização é muito frio no Inverno, apesar dos dois aquecimentos lá existentes. Mas recomendo. Boa relação preço/qualidade.Nuno2014-01-13T00:00:00Z
A nice apartment with 20 min walk to the center of Porto or a few minutes to the nearest underground station. The owners were helpful and friendly.Kelly2014-06-05T00:00:00Z
Notre sejour a été parfait. L'appartement est très bien situé et à beaucoup de charme. Un grand merci à Floriza et Luis qui ont été des hôtes très attentionnés. Thank you again.Marion2016-09-08T00:00:00Z
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
Helt hjem/leilighet
Plass til
Porto, Porto, Portugal
I wish we stayed in Porto longer because this apartment was awesome! My boyfriend and I were very happy with our stay here. The street is still developing so there are several abandon buildings but don't let that cause you any hesitation. This is a heritage building with lots of charm, and Ana has refurbished the interior into a beautifully designed and elegant home. The place is exactly as the pictures portrays. A wonderful Airbnb experience, with the gorgeous aesthetics and a fantastic host. Stay here!Caroline2016-10-23T00:00:00Z
My husband and I spent 3 nights, end of September at Ana's flat. It is amazing! beautiful moldings, nice decoration ... and very quiet even if it is on the street side. The bed is large enough and comfortable. Ana was really nice: she answered very quickly to our messages and was accommodating regarding the reservation. She welcomed us with little presents and a lot of very useful advices (where to go, where to eat, where to park ...). Thank you very much Ana for your kindness and congratulation for renovating this beautiful apartment.Anne-Sophie2016-09-25T00:00:00Z
Wir konnten wegen früher Ankunft das Appartement eher beziehen. Ana zeigte uns das wunderschöne Haus, eine alte umgebaute Silberschmiede. Wir verbrachten neun sehr schöne Tage dort. Wegen der zentralen Lage zur Innenstadt als auch zum nahe gelegnen Campanha Bahnhof konnten wir sehr einfach Ausflüge unternehmen. Das Zimmer ist angenehm groß und sehr stilvoll eingerichtet. Es war auch sehr angenehm, dass wir den Garten mitbenutzen durften.johann2016-09-07T00:00:00Z
My husband and I stayed in Porto for 2 nights and could have not found a better place than Ana's apartment. The location is only a 15 min walk to the city center. On our arrival Ana was there to greet us and made us feel very welcome. She also made sure that we had all the necessary information to make the most of our stay. The architecture of the apartment itself is absolutely stunning with perfectly suited furniture. We'll definitely come back!Sarah2016-09-10T00:00:00Z
Ana's apartments are more than perfect! Couldn't wish of anything else. Her house is probably the best designed house that I have been to so far. You won't find a single detail to criticize at her place. Besides that, Ana and Joao are lovely hosts. Always open for a glas of wine (or two) and happy to answer any kind of question. The house is not located right in the middle of the tourist-centre, but on a charming old road with everything in walking distance and also a metro station nearby. Plus we were privileged to use the stunning garden in the back of the house, to have breakfast, hang out in the evening and lay down in the sun. I honestly think, there is no better choice in Porto, thanks for sharing your house with us. See you next time!Lennert2016-07-11T00:00:00Z
João and Ana were great hosts. They borrowed me a ticket for the metro and told me what I could visit and where to go. I didn't have time to prepare my trip so this was perfect for me. I also needed to wash some clothes, and they had a laundry for the guests to use, with machines and detergent. My apartment was awesome, when I was lying down on the bed I couldn't stop looking at the ceiling, it was hypnotising. Great location!Rui2016-06-14T00:00:00Z
El apartamento de Ana es perfecto. Uno no puede dejar de mirar el fantástico techo, la decoración está genial, y no le falta ninguna comodidad, detalle, ni servicio, tal y como pone la descripción y se puede ver en las fotos del anuncio. Las camas están genial, y estuvimos perfectamente 3 personas. Se puede ir caminando al centro de Oporto pero también tiene el metro al lado, y una estación de tren a unos 10 minutos caminando que está muy bien si uno se quiere acercar por ejemplo a las bonitas playas de Gaia, o hasta Aveiro. El entorno del apartamento es muy tranquilo, y hay de todo (restaurantes, pastelerías-cafeterías, farmacia, fruterías...etc). Ana es muy agradable y además nos dió indicaciones de restaurantes y pastelerías de Oporto que ella frecuenta. Repetiría sin ninguna duda.David2016-07-27T00:00:00Z
My girlfriend and I spent 6 days in Porto and were lucky enough to book 5 nights in Ana´s loft. It was a wonderful experience, not just because of the beautiful city, but because of Ana and Joao. Ana is a wonderful host and will make you feel like you are at home. You will get some awesome tips for places to eat, drink, and have a great time. If you are lucky enough maybe you´ll be able to enjoy a cup of wine with Ana and Joao. The loft is as beautiful as it looks in the pictures and the description. If you like what you see on the website you will certainly love it when you are there. Thank you Ana and Joao for sharing your house with us and giving us the best Airbnb experience so far! See you next time!Johann2016-10-16T00:00:00Z
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Porto, Porto, Portugal
O apartamento de Daniela é amplo e confortável, bem localizado em uma zona tranquila e próxima aos principais pontos turísticos de Porto. As fotos são bem fiéis ao que encontramos. Daniela nos deixou várias informações sobre locais interessantes, bares, restaurantes e dicas sobre a cidade, além de alguns mimos. Recomendamos tranquilamente a hospedagem. Esperamos poder voltar a Porto é certamente procuraremos este local novamente. Obrigado pela acolhida Daniela.Joao 2017-03-24T00:00:00Z
This appartment is just wonderful: fully equipped, nicely decorated and in a perfect location! We were welcomed by a friend of Daniela who gave us useful information about the city and great advice about where to go. From the appartment you can easily walk to the center and the neighbourhood is really nice. Stepping out of the house, you can find a lot of nice bars and restaurants. Also, there are two supermarkets close by. All in all I would definitely recommend the appartment and will surely come back if I'll go to Porto again. Thank you, Daniela!Hanni2017-02-18T00:00:00Z
Perfect place for a visit to Porto. Centrally located and quick walk to the Ribiera district. Apartment was cozy and comfortable!Claire2016-12-16T00:00:00Z
Nous avons été très bien accueillis chaleureusement par une amie de Daniela, qui nous a donnés de nombreuses recommandations ainsi que des plans de la ville. L'appartement correspond tout à fait aux photos. Il est très bien situé dans Porto (près du marché, du Douro, des transports...). Ce fut une très bonne première expérience !Marylène2016-12-22T00:00:00Z
5 étoiles !! Appartement très propre . Grand . Bien situé . On s'y sent chez soit. Et nous n avons rien besoin d'apporter : draps , serviettes , gel douche , produit vaisselle et j'en passe ... Nous recommandons :)Manon2017-03-03T00:00:00Z
Très bon séjour chez Daniela. Appartement bien. Équipé et idéalement situé dans le centre de Porto.Maxime2017-03-28T00:00:00Z
Great place and location. Clean flat well equiped. Everything went very wellIsabelle2016-12-30T00:00:00Z
I had an amazing time at Daniels's apartment. It was in the centre of Porto and access to all tourist attractions by foot. Daniela greeted me with a bottle of port from Porto and was very helpful in showing me the tourist attraction and restaurants where the locals go to. You need to try the pork roll which is just 2 minutes walk! Thanks Daniela for a great stay. Cheers NickNick2017-02-03T00:00:00Z
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Die Unterkunft ist so wie beschrieben. Gundega und Antonio haben und sehr freundlich emfpangen und viele hilfreiche Tips gegeben. Das Umfeld der Wohnung ist sehr belebt, viele kleine Läden, Restaurants und Cafes und die Lage ist so, dass vieles zu Fuß gemacht werden kann. Die Dachterrasse ist sehr schön.Karen2014-12-27T00:00:00Z
This appartment is very well located, very clean, with everything you need, very well decorated, the terrasse amazing and the bed very comfortable ! We didn't see Gundega as she was in Lettonia, but her husband Antonia picked us up at the airport, gave us many many tips, on our way to the appartment, answered all our questions, helped us to find a restaurant as it was late in the evening, and even helped us to make our choice in the menu ! Antonio is really really very very helpful, warmful, and we felt instantanly at ease with him ! I highly recommend this appartment !Elyette2014-07-15T00:00:00Z
Nous étions attendus par Gundega et Antonio. Accueil des plus chaleureux. La barrière de la langue n'a pas gêné car Antonio a su se faire comprendre en utilisant un peu de français. Les environs nous ont bien été expliqués. La location est parfaite et les portugais très chaleureux. Nous avons passé une super semaine très chaude et très ensoleillée. La ville est magnifique et les balades à pieds superbes. Nous conseillons cette location et y reviendrons sans aucun problème.Patricia2013-07-02T00:00:00Z
We had a very good time in Porto ! The city is so lovely, there a lot of beautiful places to to see. The apartment is very nice, with a great location. Almost everything can be reach by feet. Therefore, the terrace is amazing to get some rest, to eat... Thanks for everything, Léa et Antoine.Léa2014-07-22T00:00:00Z
We had a very nice time in Porto and in the appartment and the marvelous terrace.All is near bars ,restaurants,supermarket.You can go to all the touristic highlights by feet.In the appartment is all you need.it was our second visit in Porto and we are sure we will come back.We love Porto!!!!!!!Elke2016-05-05T00:00:00Z
Wonderful place close to the center of the city. We really appreciated the tips Antonio gave us upon arrival and their help during the trip. The apartment is comfortable and the terrace unbeatable!Javier2016-01-27T00:00:00Z
Gundega and Antonio met us at the apartment (we arrived early, around 12noon) and enthusiastically explained the best places to go in Porto. They explained the neighborhood, local cafes and restaurants, supermarkets, walks. They love Porto, and gave us enough of a taste for us to love it too. During our stay they answered questions quickly. The apartment is exactly as described - a studio flat with a large terrace. It has the sun in the evening, and there are no windows overlooking - in fact you can see a lot of Porto from the terrace or window. The neighborhood is pleasant; more importantly, it's easy (and safe) walking to the sights and tastes of Porto and if you prefer to take the metro, there are two stations really close, both on the direct line to the airport. We traveled to see nearby cities - access to inter-regional stations is also greatHugo2015-10-13T00:00:00Z
Me and my girlfriend enjoyed our stay in this cozy appartment. The highlight is for sure the terrace and it is exactly how you can see it on the photos. We sat there in the evenings and enjoyed the atmosphere. Also for having breakfast outside it must be very nice. Moreover, the location of the appartment is good and you can reach most of the things easily by walking. There is a supermarket near by and also a nice café directly next to the entrance of the building. On our arrival we met Antonio. Gundega was out of town at this time. He gave us a short introduction to the appartment and a lot of advices for Porto. As we stayed only two days his advices were very helpful for making most out of our time. Thank you again for your hospitality, we felt very welcomed.gibril 2015-08-18T00:00:00Z
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Excelente apartamento, em óptimas condições num prédio praticamente novo. A casa é muito perto da estação da Campanhã. O Nuno foi impecável na nossa chegada. Recomendável a 100%.Ricardo2016-11-06T00:00:00Z
Удобные апартаменты с двумя ванными и двумя спальнями. Расположены недалеко от метро Кампанья и Героизмо. До Рибейры идти пешком примерно 20-30 минут. Так же рядом ЖД вокзал. В апартаментах чисто и есть всё необходимое, а так же небольшие бонусы от гостеприимного хозяина (фрукты, портвейн, кофе и т.п.). Кроме того, Nuno отличный хозяин, спас нас, когда мы вечером не смогли открыть дверь (я не разобрался с замком).Владислав2016-06-29T00:00:00Z
Everything about this apartment is great. It has a lot of space. It has all the facilities you need to relax (big bath, small balcony, HD tv), to cook (the kitchen has almost everything) and sleep (bed is fine). Its location is very convenient, near metro, bus and train. In about 15 minutes you can reach nice and quiet beaches by suburban train, for example Miramar. By foot it takes about half an hour to the old city center. The communication with Nuno was all fine. He was not in Porto, but his father let us in and his sister was always available for questions. The only negative point I can think of is that there is a lot of noise from the street if you want to sleep with the windows open. But with earplugs it was ok. Overall we had a very nice stay. Great value for money!Diede2016-08-28T00:00:00Z
Excelente! Nuno nos recebeu pontualmente no horário combinado! Apresentou-nos o apartamento e deu dicas sobre a cidade e o transporte público! A localização é muito boa! Fica muito próximo da estação Campanha! O apartamento é espaçoso e muito confortável! Recomendo a todos que queiram conhecer a belíssima cidade de Porto!André2016-09-16T00:00:00Z
Great place 5 minutes walking from the main train station. Spacious and we'll equipped. A bargain for what it is, However a bit cold this time of year with just one portable heating. Nuno was great communicating and all went well and smoothly.Sascha2015-11-27T00:00:00Z
Nuno was a great and kind host. He welcomed us and gave us some advice even though we arrived very late in the evening. The apartment is huge, beatiful and very clean. It was a pleasure being there and I wish I could have stayed longer. I would definitely recommend it to anyone staying there.Ivan2015-10-12T00:00:00Z
Fantastic apartment. Very close to the train station. It was full of home comforts. Nuno was great in meeting us there and making sure we had everything. There was plenty of parking on the street too. We would definitely stay here again.Natasha2016-04-11T00:00:00Z
Appartement très propre et bien situé près de la gare de Porto Campanha. Merci à Nuno qui a fait tout son possible pour rendre notre séjour agréable.les2016-07-29T00:00:00Z
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Product Description
Signed Damian Toya, this is an early, lovely work by the artist who now uses the name Dominique Toya, and who has won many, many, accolades and awards, including Best of ( all the pottery) Division at Santa Fe Indian Market! Lately, the celebrated potter Nancy Youngblood has formed an award-winning, collaborative relationship with this gifted artist resulting in more awards for each of them.
The natural clay, which was hand-gathered, -mixed, -coiled, -smoothed, -coated with a red clay slip and stone polished, is a mellow beige. It was also pit-fired. The beautiful cornstalk waving so gracefully across the front was painted with the same red clay slip, left matte, and a dark paint derived from wild spinach. Shaped into an unusual triangular form, the piece has a stepped top, symbolizing rainfall. Rain is needed for cornstalks to thrive, therefore the symbols refer to the eventual happiness and good health that come with a good harvest.
Although called a vase, this lovely piece should NEVER hold water! It would, however take prettily to dried or artificial branches, flowers, or foliage. This is a real collector's item, comprising a lovely, early work by an artist who has now reached the highest ranks of potters.


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Frank Christie
|Personal information
|Full name
|Frank Christie[1]
|Date of birth
|17 February 1927
|Place of birth
|Balbeggie, Perthshire, Scotland
|Date of death
|12 September 1996(aged 69)
|Place of death
|Perth, Scotland
|Playing position
|Wing half
|Youth career
|Scone City Boys
|St Johnstone Young Men's Club
|Senior career*
|→ Forfar Athletic (loan)
|Forfar Athletic[2]
|East Fife
|Teams managed
|East Fife
|* Senior club appearances and goals counted for the domestic league only.
Frank Christie (17 December 1927 – 12 September 1996) was a Scottish football player and manager.
Playing career[edit]
Christie started his career at amateur side, St Johnstone Young Men's Club, Perth, Scotland.
He was signed by Liverpool on 17 July 1945 and subsequently loaned to Forfar having failed to break into the Liverpool first team from Liverpool's Central League reserve side. Forfar signed Christie permanently at the end of the 1945/46 season, where he enjoyed three years at the club before rejoining Liverpool F.C in March 1949. He played in four of Liverpool's League matches towards the end of the 1949–50 season, making his debut in defence alongside the likes of Bob Paisley and Phil Taylor in a fixture away to Manchester United on 15 March 1950 at Old Trafford before a crowd of 45,283.[3]
In January 1951, East Fife paid Liverpool an £8,000 transfer fee to bring Christie back to Bayview. He spent the large part of his playing career at East Fife, and scored the winning goal[4] in East Fife's 3–2 victory over Partick Thistle in the 1953–54 Scottish League Cup Final at Hampden Park, Glasgow in front of 38,529.
Coaching career[edit]
In the summer of 1963, when St Johnstone FC manager Bobby Brown was restructuring his backroom staff, he appointed Frank Christie as first team trainer. This would prove to be a wise decision as Frank became a vital part of the management team. When Brown moved on to the role of Scotland national football team manager in 1967, Christie was placed in temporary charge of St Johnstone's team selection until the appointment of Willie Ormond as manager. His partnership with Ormond saw the team enter one of the most successful periods in the club's history. Following Ormond's move to the role of national team manager, Christie moved to East Fife as manager. Christie managed East Fife until 1976, and steered them to their first (and only) victory in a competitive match during peace-time over Glasgow Rangers defeating them 1–0 at Ibrox on 13 October 1973.[5] Christie was closely associated with Scottish Junior team Scone Thistle whom he also managed.
In 1976 Jim Storrie brought him back to Perth. He had a further period in temporary charge after Storrie's resignation and the arrival of Alex Stuart in 1978. In 1985 when Saints were experiencing severe financial difficulties he was a casualty of the cost cutting exercise thus ending a 21 years association with St Johnstone.
Personal life[edit]
Frank's brother James (Jock) Christie played Centre-half for Dundee United F.C..[6]
- East Fife
- Scottish League Cup (1): 1953
- ^ "Frank Christie". Barry Hugman's Footballers. Retrieved 9 April 2017.
- ^ "Christie, Frank". Fitba Stats.
- ^ "Manchester United v Liverpool match report". LFC History. 15 March 1950. Retrieved 21 August 2015.
- ^ "Frank Christie nets the winner". LFC History. Dundee Courier. 26 October 1953. Retrieved 21 August 2015.
- ^ "East Fife History – 1970s". East Fife F.C. Retrieved 21 August 2015.
- ^ "Dundee United History – James Christie". Dundee United F.C. Retrieved 21 August 2015.
External links[edit]
- Frank Christie, Neil Brown
- Frank Christie Biography, LFChistory,.net
- Frank Christie nets the winner, Dundee Courier
- 1927 births
- 1996 deaths
- People from Perth and Kinross
- Association football wing halves
- Scottish footballers
- Forfar Athletic F.C. players
- Liverpool F.C. players
- East Fife F.C. players
- English Football League players
- Scottish Football League players
- Scottish football managers
- East Fife F.C. managers
- Scottish Football League managers
- St Johnstone F.C. non-playing staff


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|print source: here
A favorite pastime in Sewtopia is reading. Let me be clear, I don't do romance. Just about anything else is good for me. Current read is The Residence: Inside the Private World of the White House, by Kate Anderson Brower. (Available at amazon.com) Full of fascinating stories about the Residence Staff at the White House from the Kennedy's to the current, I feel a new respect for the workers there. I fear I would never have the patience to tolerate all the whims and weird requests made by certain presidents, wives and families. In this contentious election year I suspect the staff are all in great suspense to find out if the difficult Clintons or the unknown Trumps will be their charge. God Bless the USA!
Sunday, May 29, 2016
An Evening at Home
Posted by celkalee at 1:00 AM
Labels: Kate Anderson Brower, leisure reading, quilting, reading, secrets, The Residence
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No word on Officemail fault compensation
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Telecom is declining to say whether it is offering compensation to customers who were affected by problems with its Officemail email service last week.
Firms faced delays of several days receiving email late last week, with some claiming their businesses had been severely disrupted.
Telecom spokeswoman Jo Jalfon said it continued to "liaise with those impacted on an individual basis".
However, she would not clarify whether that meant Telecom was offering compensation to Officemail users that approached it seeking redress.
"Officemail is used by both business and residential customers and the impact of the problem varied greatly between the two - hence our commitment to address customer concerns on an individual basis," she said.
Telecom told Fairfax Media that "several thousand" individual email users were affected. Radio New Zealand later reported the number at 20,000.
Telecom Retail head Chris Quin, who was in India when the problems arose, today wrote to Officemail users to apologise for the disruption.
He said Telecom was urgently reviewing Officemail's technology platform and putting in place "system changes" to ensure it improved customer communication.
Quin said he recognised the fault might have undermined customers' confidence not just in Officemail but in Telecom overall, and he would try and win it back.
The problems last week were triggered by a third-party mailing house sending out a large volume of seasonal promotional material, overloading Officemail's servers.
- The Dominion Post
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Enforcement officials in Malaysia have seized 18 rhinoceros horns imported from Mozambique, weighing 51.4 kg and worth 13.7 million ringgit (USD 3.1 million), a senior customs official said Monday. Airport customs director Hamzah Sundang said officials acting ...Business Standard, 2 weeks ago
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NYC Parks Events Calendar
Get up, get out, and do something! Just about any day of the year, you can find something fun, informative, and healthy to enjoy at an area park. Feel free to browse the listings below, or use the search tools to find an event that matches your interests and location.
Viewing 14,241–14,250 out of 14,933 events
from November 9, 2012 (x) to April 15, 2018
Saturday, July 22, 2017
It's My Park at Conference House Park
at Conference House Park Visitor Center (in Conference House Park), Staten Island
10:00 a.m.–12:00 p.m.
Volunteers will help with gardening preparation and beach cleanup to get the park ready for the spring/summer weather and upcoming events.
Category: Nature, Volunteer, It's My Park
Summer on the Hudson: Butt & Gut
at Soldiers' and Sailors' Monument (in Riverside Park), Manhattan
10:30 a.m.–11:15 a.m.
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at 125th Street and Marginal Street (in West Harlem Piers), Manhattan
11:00 a.m.–12:00 p.m.
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Category: Dance, Fitness, Sports, Waterfront, Outdoor Fitness
Urban Farm Exploration Day
at Urban Farm (in Randall's Island Park), Manhattan
11:00 a.m.–5:00 p.m.
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2:00 p.m.–3:00 p.m.
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Sunday, July 23, 2017
Summer on the Hudson: Tai Chi
at Soldiers' and Sailors' Monument (in Riverside Park), Manhattan
8:00 a.m.–9:00 a.m.
Join Silvana Pizzuti to learn and practice Tai Chi, a slow moving martial art with health benefits for all fitness levels.
Category: Accessible, Fitness, Waterfront, Outdoor Fitness, Seniors
Urban Farm Exploration Day
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11:00 a.m.–5:00 p.m.
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Free Boatbuilding at Pier 40
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12:00 p.m.–6:00 p.m.
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Category: Volunteer, Waterfront
Summer on the Hudson: SunGaze
at Pier I (in Riverside Park South), Manhattan
12:00 p.m.–4:00 p.m.
Gaze at the central star of our solar system using special safe scopes with the Amateur Astronomers Association!
Category: Accessible, Education, Best for Kids, Waterfront, Astronomy
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A simple setup built to take timelapse photos on a camera without an intervalometer. It consists of a servo, a arduino, and a HD44780 controlled LCD. For anyone with newer cameras, the Canon Hack Development Kit (CHDK, Google it) allows intervalometer scripts to be used on cameras, unfortunately this model that I had around does not support this feature.
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Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s00277-011-1357-2
- Cite this article as:
- Song, MK., Chung, JS., Shin, HJ. et al. Ann Hematol (2012) 91: 697. doi:10.1007/s00277-011-1357-2
- Citations
- 821 Downloads
The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL who underwent measurements with PET prior to rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). Cutoff point of MTV was measured using the receiver operating characteristic (ROC) curve. During a median period of 36 months, stage II was 59.2% and III was 40.8%. Using the ROC curve, the MTV of 220 cm3 was the cutoff value. The low MTV group (<220 cm3) had longer progression-free survival (PFS) and overall survival (OS), compared with the high MTV group (≥220 cm3) (p < 0.001, p < 0.001). Stage II patients had longer survival than those in stage III (PFS, p = 0.011; OS, p = 0.001). The high MTV group had lower PFS and OS patterns, regardless of stage, compared with the low MTV group (p < 0.001, p < 0.001). Multivariate analysis revealed an association of the high MTV group with lower PFS and OS (PFS, hazard ratio (HR) = 5.300, p < 0.001; OS, HR = 7.009, p < 0.001), but not stage III (PFS, p = 0.187; OS, p = 0.054). Assessment of MTV by PET had more potential predictive power than Ann Arbor stage in the patients that received R-CHOP.
KeywordsDiffuse large B cell lymphoma Positron emission tomography Rituximab
Introduction of rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP) has resulted in improved survival outcomes in patients with diffuse large B cell lymphoma (DLBCL) [1, 2, 3, 4, 5, 6, 7, 8]. DLBCL is a heterogenous group of B cell non-Hodgkin lymphoma (NHL), rather than a single clinicopathologic entity [9]. Multiple histologic subtypes were recognized and several molecular and genetic abnormalities were variably present. In recent years, most studies have focused on identifying molecular markers in order to define new prognostic factors. However, no relevant prognostic molecular markers have been validated, and an agreement on prognostic models has not yet been reached [10].
Aggressive NHL, including DLBCL, has been staged according to the Ann Arbor staging system, which was originally designed for Hodgkin lymphoma (HL). The International Prognostic Index (IPI) is the primary clinical tool used to predict the outcome for patients with aggressive NHL based on the number of negative prognostic factors at the time of diagnosis, including Ann Arbor stage III/IV and other factors (age ≥ 60 years, elevated lactate dehydrogenase level, Eastern Cooperative Oncology Group performance status ≥2, more than one extranodal site) [11]. However, due to the higher heterogeneity and hematogenous spread pattern of dissemination in NHL relative to contiguous lymphatic spread with HL, Ann Arbor staging system has limited value in the context of assessing accurate tumor burden in NHL. For instance, despite the presence of a high tumor burden in stage II disease, the IPI score can be "zero point," whereas the score can be "one point" in stage III disease even if the tumor burden is low.
New imaging techniques such as 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) have been used as prognostic tools in NHL [12, 13]. As indicated by several positive sets of data, imaging techniques have become an important tool in clinical decisions on therapeutic strategies for treating aggressive NHL, including DLBCL [14, 15, 16]. The objective of the present study was to investigate whether metabolic tumor volume (MTV) by PET can be used as a potential prognostic tool, compared with the Ann Arbor stage, in patients with stages II and III nodal DLBCL.
Materials and methods
The baseline characteristics and comparison between stages II and III nodal DLBCL patients
Total (n = 169) (%)
Stage II (n = 100) (%)
Stage III (n = 69) (%)
p value
Age, median, years (range)
61.0 (21–79)
62 (22–79)
59 (21–76)
Sex, male/female
Disease status
Age ≥ 60 years
98 (60.0)
63 (63.0)
35 (50.7)
Elevated LDH
77 (45.6)
43 (43.0)
34 (49.3)
ECOG at least 2
42 (24.9)
21 (21.0)
21 (30.4)
B symptoms
71 (42.0)
37 (37.0)
34 (49.3)
Bulky LN (≥5 cm)
7 (4.1)
3 (3.0)
4 (5.8)
MTV, median, cm3 (range)
198.1 (4.5–1,990.7)
122.1 (4.5–1,251.1)
434.3 (10.1–1,990.7)
IPI score, n (%)
125 (73.9)
78 (78.0)
47 (68.1)
44 (26.1)
22 (22.0)
22 (31.8)
Response by revised IWC
142 (84.0)
87 (87.0)
61 (88.4)
21 (12.4)
13 (13.0)
5 (7.2)
6 (3.6)
0 (0.0)
3 (4.3)
Survival (%)
3-year PFS
3-year OS
Inclusion and exclusion criteria
Patients were included if they had primary nodal localization as a de novo DLBCL histotype, and the stage was II or III according to Ann Arbor staging and had been available for clinical follow-up. Patients were excluded if they presented any extranodal involved site, DLBCL secondary to low-grade NHL, or other treatment, including radiotherapy after R-CHOP therapy or autologous stem cell transplantation and if there was a discrepancy in the LNs between PET and conventional computed tomography (CT). In addition, patients were excluded if they had uncontrolled diabetes mellitus, evidence of infection at the time of diagnosis, especially active tuberculosis, or antibodies against human immunodeficiency virus.
Measurement of MTV by PET/CT
Dual-modality PET/CT tomography was performed on a biograph (Siemens Medical Solution, Hoffman Estates, IL, USA), based on a dual-slice helical CT and a full-ring PET tomography. FDG-PET images were evaluated for regions of focally increased tracer uptake. In the target lesions of FDG tracer uptake, SUV of ≥2.5 as contouring border was considered to represent lymphoma, as suggested by Freudenberg et al. [17]. The CT images were used for PET attenuation correction. Imaging reconstruction of corrected emission data was performed after Fourier transform with AWOSEM software (two iterations, eight subsets, 5 mm Gaussian filter). The CT criterion for pathologic LN was that the LN exceeded 1.0 cm in all regions, except the groin. PET image also evaluated the area of focal tracer uptake; thus, the SUV of ≥2.5 was considered as pathologic LN, and the MTV was measured after CT attenuation correction. CT images were acquired with 130 mAs, 130 kV, and slice width (or 5 min and table feed) of 8 mm per rotation. Intravenous or oral contrast agents were used in all patients, and a standardized breathing protocol was applied. PET images were interpreted by nuclear physicians at each institution. Data were then reviewed by two nuclear medicine experts at Pusan National University Hospital.
Pretreatment and response evaluation
Pretreatment staging and response evaluation after six or eight cycles of R-CHOP therapy were based on clinical examination, CT scan of the neck, chest, abdomen, and pelvis, bone marrow biopsy, and PET/CT. Response was assessed according to revised International Workshop Criteria [14]. Criteria were as follows: complete response (CR) is defined as (a) no signs or symptoms of disease, (b) negative PET and regression to normal size on CT, and (c) normal bone marrow. Partial response (PR) is defined as 50% decrease in tumor size but with a positive PET at the prior disease site. Stable disease (SD) is defined as (a) positive PET at the prior sites of disease and no new sites on CT or PET and (b) PET negative and no change in size of previous lesions on CT. Progressive disease is defined as (a) appearance of a new lesion >1.5 cm in any axis, ≥50% increase in the sum of the product of the diameters of more than one node, or ≥50% increase in the longest diameter of a previously identified node>1 cm in short axis and (b) lesions PET positive if FDG-avid lymphoma or PET positive prior to therapy.
Statistical analyses
The Mann–Whitney U test was used for assessment of differences in the frequency-independent prognostic factors of stages II and III groups. Progression-free survival (PFS) was calculated from the date of diagnosis to documented disease progression; observations were censored on the date the patient was last known to be alive or, for patients dying as a result of causes unrelated to lymphoma or treatment, the date of death. Overall survival (OS) was calculated from the date of diagnosis until death as a result of any cause or the date last known to be alive. PFS and OS were estimated by the Kaplan–Meier method, and the difference was compared using a log-rank test. Receiver operating characteristic (ROC) curve was performed for estimation of the accuracy in prediction of ideal cutoff value of MTV. Estimation of sensitivity and specificity was based on the cutoff value of MTV. SPSS software for Macintosh (SPSS 15.0; Chicago, IL, USA) was used for statistical data processing. A probability value <0.05 was considered statistically significant.
Patient characteristics
One hundred sixty-nine patients with stage II/III nodal DLBCL were treated with R-CHOP from 2004 to 2008, and the baseline characteristics were summarized in Table 1. Differences of several independent prognostic factors between stages II and III groups were not observed. However, MTVs in the stage III group were larger when compared with the stage II group (p < 0.001). CR and PR of the treatment response were comparable between the two groups (p = 0.786, p = 0.236, respectively), whereas SD was higher in the stage III group when compared with the stage II group (p = 0.036, Table 1).
Measurement of cutoff value of MTV in patients at diagnosis
Clinical outcome according to stage or MTV
Clinical outcome according to stage combined with MTV
Further analysis was performed to determine whether tumor burden was of clinical importance between stages II and III nodal DLBCL patients. Outcomes were compared among the four subgroups based on tumor burden and stage II or III (stage II group with low MTV, stage II group with high MTV, stage III group with low MTV, and stage III group with high MTV). The high MTV group, regardless of stage, had lower PFS and OS patterns, compared with the low MTV group (PFS and OS in stage II with low MTV, 90.5% and 95.2%; in stage III with low MTV, 88.0% and 88.0% versus in stage II with high MTV, 60.5% and 65.8%; in stage III with high MTV, 51.2% and 51.2%; p < 0.001, p < 0.001), whereas the prognostic impact of stage in the same MTV group was absent (in the low MTV group, difference of PFS and OS according to stage, p = 0.703, p = 0.268; in the high MTV, p = 0.347, p = 0.175, Fig. 2c, d).
Univariate and multivariate analysis
Univariate analysis for prognostic factors in patients
Prognostic factors
Progression-free survival
Overall survival
p value
p value
Stage III
2.094 (1.162–3.773)
2.758 (1.454–5.234)
High MTV
5.797 (2.787–12.055)
8.097 (3.395–19.309)
Multivariate analysis for prognostic factors in patients
Prognostic factors
Progression-free survival
Overall survival
p value
p value
Stage III
1.496 (0.822–2.724)
1.894 (0.988–3.628)
High MTV
5.300 (2.517–11.162)
7.009 (2.902–16.927)
Since its publication in 1971, Ann Arbor staging has been used as the staging system for both HL and NHL lymphomas [15]. However, the number of involved nodal sites was not considered in this optional staging system. For these reasons, the Ann Arbor scheme was revised, and modifications in the staging procedures were recommended within the framework of the Ann Arbor Classification by a committee meeting in the Cotswolds under the auspices of the Cancer Research Campaign and Imperial Cancer Research Fund [16]. However, accurate tumor burden was also not considered in the staging system. Interestingly, one previous study demonstrated that tumor burdens could be discriminated (i.e., low tumor burden vs. high burden) based on the number of extensive nodal areas and extranodal sites [18]. The author of this study suggested that tumor burden measured by their method was an excellent prognostic factor in CHOP era. However, this method only involved a simple arithmetic system, and no imaging techniques were utilized. Because accurate tumor surveillance is a fundamental precondition for assessment of prognosis and therapeutic options in patients with NHL, a more accurate staging system model should be developed, especially in the era of rituximab.
A recent meta-analysis study, based on data from three large clinical trials, suggested that treatment with rituximab resulted in significant improvement of the treatment outcome within each of the four IPI factors, including Ann Arbor stage [19]. Of particular interest, the study revealed data from the MabThera International Trial, where the advanced stage (III/IV) was no longer an independent factor of OS in multivariate analysis. In this study, data from the MegaCHOEP Trial also demonstrated that the advanced stage showed borderline correlations with PFS and was not associated with OS. In addition, data from the RICOVER-60 trial shown in this study demonstrated that the advanced stage was not an independent factor of PFS and OS. These findings indicate that treatment with rituximab resulted in improved outcome of advanced stage patients and diminished gap of survival between the limited stage and advanced stage according to the Ann Arbor staging system. For these reasons, we do not believe that the advanced stage itself would be a true poor prognostic factor in the era of rituximab. According to the results of meta-analysis in the above clinical trial, the authors demonstrated that four IPI factors were independent factors. However, it did not address several discrepancies, including patient characteristics, using regimens other than CHOP and a different treatment schedule in each clinical trial.
Development of imaging techniques such as 18F-FDG-PET has resulted in increased diagnostic accuracy and allowed clinicians to distinguish primary malignant lesions from benign areas. Thus, 18F-FDG-PET has been reported to provide superior information on staging of NHL when compared with conventional CT scans. Interestingly, two recent studies showed that tumor burden measured by PET could be used to measure the actual tumor burn of lymphoma [20, 21]. One of these studies showed that active tumor burden based on PET might be a prognostic indicator of volumetric response [21]. Volume assessment in these studies was based on percent reduction in SUVmax. However, in the present study, we used a volume measurement process that included a cutoff value of absolute SUV volume measurement, as described by Freudenberg et al. [17].
PET using the tracer 18F-FDG incorporates metabolic tumor function with anatomic localization. Tumor volumes by PET in solid tumors have been associated with clinical outcome in several studies [22, 23]. However, to the best of our knowledge, clinical application of tumor burden by PET as a new staging tool has not yet been reported in DLBCL patients treated with R-CHOP therapy.
The findings reported in the present study suggest that total tumor burden of lymphoma is a more important prognostic parameter than Ann Arbor stage for assessing DLBCL. In the multivariate analysis, a high MTV had a greater clinical significance than stage III in survival. This result demonstrates that the Ann Arbor staging system has limited use in assessing DLBCL due to the heterogenous spread pattern of NHL in contrast to HL. Therefore, overall assessment of tumor burden of lymphoma may be needed before treatment strategies can be developed. In addition, the clinical outcome was not different for the patients in the same MTV state; however, the stage was different. These results suggest that a simple classification for prognosis according to diaphragm would not be wise, at least for DLBCL, in the era of rituximab. The present study was conducted to analyze the clinical importance of MTV between only nodal stages II and III DLBCL patients. Therefore, a further well-designed study including all nodal stages and extranodal sites is needed.
In conclusion, quantitative assessment of metabolic tumor volume using PET may potentially be more useful in the prediction of clinical outcome than the Ann Arbor staging system in stages II and III of exclusively nodal involved DLBCL patients treated with R-CHOP.
This study was supported by a grant from the national R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (0920050) and supported by a grant of the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A070001).
Disclosure statement
None declared.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


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- Everything went just fine.
The staff at the hotel were very pleasant at all times. Nothing was to much trouble.
Room was clean, fresh and tidy albeit a bit cramped but for on night it was just fine.
Could not fault anything at all.
Mr Dennison, 08 Nov 2016
- Everything went well very comfortable Premier Inn,perfect for airport. Airport parking smooth just arrived and put ticket in to leave. Number plate recognition no que.
Mr Sharp, 29 Oct 2016
- Facilities and room good, just an overnight stop and early rise so no breakfast. Only slight hitch couldn't initially get out of the pre booked car park on return which used number plate recognition Had to provide booking ref no to attendant
Mr Stevenson, 16 Oct 2016
- The staff were very friendly and helpful. We had issue with room but this was resolved quickly. Only issue was the restaurant was closed although we could eat in the bar area
Mrs Davenport, 14 Sep 2016
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Overall Rating: 90% based on 3821 Votes
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GEORGE MICHAEL I Want Your Sex (1987 Japanese 7" vinyl single, also including Genius, with a unique wrap-around picture sleeve with lyrics inside. This is an ex-rental copy and has a rental & barcode sticker on the front, otherwise shows minimal wear whilst the vinyl shows only light signs of play 07.5P-476)
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Is she drunk on her way home from the club? along side the Cosmo?
I see some of our towns folk don't get out on Sunday around 6:30. She is a (let's just say)leftover from Saturday night festivities.
Yes Joe she was having a rough time walking her her heels, she nearly tipped over into the bushes.
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School evacuated ahead of Qld bushfire
A primary school north of Brisbane has been evacuated as two large grassfires burn in the area.
The students and teachers at Narangba State School have been moved to a nearby community centre as a precaution, with the grassfires burning near Narangba Road and Boundary Road at Kurwongbah.
Sixteen fire crews supported by water-bombing helicopters have the fire contained at this stage, with no current threat to properties.
Meanwhile, Queensland Fire and Emergency Services has issued a Watch and Act alert for residents near Fernvale, west of Brisbane, with a large bushfire in the area.
Fifteen fire crews are working to contain that blaze, however they are experiencing difficulty controlling it.
Residents to the northeast of Fernvale are being urged to leave immediately or enact their bushfire plans.
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Explore Giants Gang, Niners Giants, and more!
Brandon Crawford
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Tim Lincecum #55 of the San Francisco Giants is lifted by Buster Posey #28 after pitching a no hitter during a baseball game against the San Diego Padres at Petco Park on July 13, 2013 in San Diego, California. Lincecum pitched a no-hitter.
6/14/13. I just love this picture of BUSTER POSEY and BRANDON CRAWFORD, just sitting in the dugout --- perhaps smiling over some inside joke. They really look like 2 kids that just love to play baseball. In fact, they're two of the best players in the world at their respective positions.


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Round neck top with studs and faux leather piping. Teardrop detail on the front. Long sleeves with buttoned cuffs. Faux leather metallic details on the hem.This item has a small fit. We recommend you buy a size larger than your usual size.HEIGHT OF MODEL: 177 cm.
COLOR: Black