text:
The Tweeks
Craig's family
Mr. Adler, shop teacher
Pearl, home ec teacher
Mr. Adler's Grandma
Mr. Adler's Uncle Corey
[South Park Elementary. The school bell rings. Most of the third-grade boys are in a shop room.] | ||
Voice: | [male] This is shop class. [it belongs to a heavyset man, who stands next to a chalkboard, pointing to the information] My name is Mr. Adler. For the next week, rather than your normal schoolwork, you'll be learning how to make things. Now, does anybody know WHY you're in shop class? [Stan raises his hand] Yes? | |
Stan: | Because we had to choose between this and home ec, and we didn't wanna be sissies? | |
Mr. Adler: | Wrong! You are here because you are America's future! [sittiring music plays] You may someday be doctors, or lawyers, or scientists. Most of you, however, will be pumping gas, or cutting sheet metal, and that's why we have… [points to the words] shop class. | |
Cartman: | Ooooohh. | |
Mr. Adler: | Now, let me make one thing crystal clear: I don't like kids that screw around! You screw around in shop class, you can lose a hand or an eye. I have a- [picks up a picture of a woman and begins to get lost looking at it] I have… uh, I have a… | |
Kyle: | Mr. Adler? | |
Mr. Adler: | [sets the picture down] Huh? Oh, uh, I was just saying that I want to know who is the biggest troublemaker in your class? | |
Stan: | [quickly points] Tweek is! | |
Tweek: | Arrh! No, I'm not! | |
Kyle:Stan: | Yeah, you are! You always get in trouble | |
Tweek: | Arrrrh! | |
Cartman: | Oh, hello, excuse me, but Craig is the biggest troublemaker in our class. | |
Mr. Adler: | That true, Craig? You a troublemaker? | |
Craig: | No. | |
Mr. Adler: | Well, you'd better not be, because in shop class we- [Craig flips him off] Hey! Did you just flip me off?! | |
Craig: | No. | |
Mr. Adler: | Yes, you did! | |
Cartman: | Told ya! | |
Kyle: | [hushed, to Stan] Dude, shop class sucks. Maybe we should have taken home ec. | |
Stan: | Now way, dude. Home ec is for girls. | |
[The Home Economics room. All the girls are here] | ||
Voice: | [female] Welcome to home ec. [the camera scans across the class] For the next week, you will be learning how to bake, sew, clean, and make things that are lacy and pretty. [Kenny appears] | |
Kenny: | (Woohooo!) [Wendy raises her hand] | |
Wendy: | I requested to be in shop class, but they sent me here. | |
Woman: | That's right, Wendy. You see, some of you girls will go on to have interesting jobs and careers. [now cautioning] But all of you pretty ones… won't have to worry about that, because you can marry a nice man. And that's why we have… home ec. | |
Kenny: | (Woohooo!) [the girls on either side of him look at him] | |
[The Shop room. Stan, Kyle, and Cartman sit before a power miter box. Cartman is feeding it wood] | ||
Cartman: | I wonder why Kenny didn't wanna take shop class? [cuts out two slabs] | |
Stan: | I don't know. He's such a wuss. | |
Mr. Adler: | [passing by] Hey! Don't screw around! You screw around too much! | |
Cartman: | You know, you guys are totally wrong about Tweek. Craig is way worse than he is. [Craig leafs through some wood scraps, and Tweek approaches a belt sander on the floor] | |
Stan: | No he's not dude. Craig is a wuss. | |
Cartman: | Dude, if Craig and Tweek got in a fight, Craig would kick Tweek's ass. | |
Kyle: | Do you wanna bet? | |
Cartman: | Yeah, I'll bet. | |
Stan: | How much? | |
Cartman: | Five bucks. | |
Stan: | You're on! | |
Tweek: | [revs up a belt sander.] Arrh! [jumps. Stan and Kyle walk to him] | |
Stan: | Hey Tweek. | |
Tweek: | [jumps] Gaarhrhrh! | |
Stan: | Dude. Craig chooses you. He wants to fight. | |
Tweek: | [drops the sander] He does? | |
Stan: | Yeah. He's all pissed off at you. So, will you fight? | |
Tweek: | Why? | |
Kyle: | Dude, because! You have to stand up for yourself! So will you fight him? [Craig is still leafing through the scraps] | |
Tweek: | [jumps] Rrrrh! He doesn't look like he wants to fight me. | |
Cartman: | Craig, could I talk to you real quick? [Craig flips him off, and Cartman puts his palms up to calm him] Er, just a second, please, Craig. Craig, I'm not normally one to get involved in this kind of thing but, well, I was just standing over by Tweek, and, he called you a big poop-eater. | |
Craig: | He did? | |
Cartman: | Yeah. He said you eat poop, and that it makes your breath smell like poop, and that, eh, well, you like it. | |
Craig: | Why would he say that? | |
Cartman: | I don't Craig, I don't know. But now he's over there telling everybody that you're a poop-eater and he chooses you. | |
Craig: | [now pissed] Well, I've gotta go over there and- | |
Cartman: | [blocks his way] No, no! Craig, you you can't fight him here; Mr. Adler would just break it up. Tell you what: I'll go tell him you accept his challenge, and set it up for after school today. | |
Craig: | Okay. [flips Tweek off] | |
Kyle: | There. Did you see? He just flipped you off. | |
Tweek: | [twitches to one side] Rrrr! What a jerk! | |
Stan: | He's really got it out for you, dude. | |
Tweek: | Why?! What did I do?! | |
Kyle: | So, do you agree to fight him after school? | |
Tweek: | I guess so. | |
Stan: | Super. See you there. [they walk away, pleased] | |
[Mr. Adler takes out the woman's picture again and looks at it. He begins to daydream. Memories of his fiancée come to him, and her voice echoes every time reminisces] | ||
Fiancée: | [runs from him] Catch me, Richard. [she laughs even after he catches her and she's on the grass] I'm so in love with you, Richard. [next scene: she's in the kitchen holding a tray] I made you some cookies, Richard. [sniffs them real good. Next, she's by the fireplace with a little stocking] Merry Christmas, Richard. [laughing on the yard outside] Oh, Richard. Say you'll hold me forever. [in flight, trying to regain control] Aaaaaaa! [in a swimming pool, under water] Richard! | |
[the school bell rings, and he's back] Aaaarr! Uh. [opens a drawer to get some nicotine gum, and chews some] Oh why? Why? [closes his eyes and continues chewing] | ||
Stan: | Mr. Adler! Mr. Ad-ler! | |
Mr. Adler: | Huhuh Huh? Stop screwing around! | |
Stan: | The bell rang. Can we go? | |
Mr. Adler: | Well, uh, well, sure. Uh, class dismissed. | |
Stan: | Come on, you guys. [Kyle and Cartman follow him out] | |
[The school yard] | ||
Stan: | This is gonna be so sweet, dude. | |
Cartman: | You guys are so wrong about Tweek. He's gonna get his ass kicked. | |
Kyle: | We'll see! | |
Cartman: | Why don't we just raise our bet to ten dollars?! | |
Stan: | You're on, fatass! [Kenny shows up] | |
Cartman: | Well, well, well, look who's here! Our little home economics friend, Kenny! | |
Kenny: | (Hey guys, what's going on with you?) | |
Stan: | How come you wanna take home ec., Kenny? | |
Kyle: | Yeah. That's not cool, dude. [the girls walk by] | |
Bebe: | Bye, Kenny. See you tomorrow. | |
Jordan: | Bye, Kenny. | |
Kenny: | (Bye, ladies.) [the other boys arrive as the girls leave] | |
Clyde: | Hey, what's going on? | |
Kyle: | Tweek and Craig are gonna fight. | |
Clyde: | Really? Cool. [the boys stand around waiting] It's funny, 'cause Tweek and Craig both went home about fifteen minutes ago. | |
Kyle: | What? | |
Token: | Yeah, they left. | |
Stan: | Aw, hell! | |
Cartman: | Those sons of bitches! | |
Clyde: | I guess they don't wanna fight. | |
Kyle: | Aw, they wanna fight! They just don't know it yet! [walks off with Stan, Cartman, and Kenny] | |
[Stan and Kyle arrive at Tweek's house. Stan rings the bell] | ||
Stan: | Tweek? | |
Kyle: | [looks up to the second floor] Tweek? | |
Tweek: | [opens the center window] Herr. What do you guys want? | |
Stan: | How come you didn't show up for the fight, Tweek?! | |
Tweek: | Craig and I have no reason to fight each other. | |
Kyle: | Well, Craig showed up. | |
Tweek: | He did? | |
Stan: | Yeah. He was standing there waiting for you, and he was all like, "Man, Tweek's a wuss," and we were all like, "No he's not, Craig," and he was all like, "Yeah he is, he isn't showing up. He's a big wuss, and he has crooked teeth!" | |
Tweek: | I don't have crooked teeth! | |
Kyle: | And then Craig was all like, "Tweek is scared o'me. He's a big chicken." And he started doing an impersonation of you being a chicken [Stan watches as Kyle demonstrates]; well, everybody in the world saw it! | |
Tweek: | Everyone in the world?! Rrrr! [falls down behind the window] | |
Stan: | Yeah, it was weak. | |
Tweek: | I'm not a chicken! | |
Kyle: | Well, everyone in the world thinks you are. See ya. [turns to walk away] | |
Tweek: | [pops up] Wait! I'll fight! | |
Stan: | Tomorrow? | |
Tweek: | Okay. | |
[Cartman and Kenny arrive at Craig's house. Cartman knocks and Craig answers.] | ||
Cartman: | Craig, what the hell are you doing home?! You're supposed to be out fighting Tweek! | |
Craig: | Red Racer's on. | |
Cartman: | Craig, you can watch Red Racer any day of the week! | |
Craig: | I do watch Red Racer every day of the week! | |
Cartman: | [aloof] Well, that's fine. I guess you don't care about what Tweek said about your mom. | |
Craig: | Nnope. [shuts the door] | |
Cartman: | [hushed] Egh. God-damnit! [knocks again, and Craig answers] Well, I guess you don't care about what Tweek said about your guinea pig. | |
Craig: | What?! What did he say about Stripe?! | |
Cartman: | Oh, nothing, except that you stick it up your ass before you go to bed. | |
Craig: | That son of a bitch, I'll kill him! | |
Cartman: | Yeah, I'd be pissed too, so maybe we should reschedule the fight for tomorrow? | |
Craig: | After Red Racer. | |
Cartman: | [being graceous] After Red Racer, of course. | |
[The Tweek house, that night, dinner. The Tweeks are at table] | ||
Richard: | How was school today, son? | |
Tweek: | Errh! | |
Richard: | That's great. | |
Tweek: | Dahad, if some kid in school wants to fight me, what should I do?? | |
Richard: | Son, let me tell you a little story about when your mother and I first met. [gets up and stands next to her. Peaceful music plays] You see, a long time ago, there were a lot of guys who were after your mother. She used to be very attractive. | |
Mom: | It's true. I was. [Tweek bobs as he listens] | |
Richard: | Well, when I started courting your mother, there was this big muscular football player named Quib, who didn't take too kindly to me. He wanted your mother all to himself. And so, one day, he challenged me to a fight. [sits down, and both parent resume eating. Tweek waits for the rest of the story] | |
Tweek: | [after a long lull] Well? | |
Mom: | Well what, honey? | |
Tweek: | Nrr. What happened? | |
Richard: | Oh'd. I, I don't know. He moved away or something. | |
Mom: | Yes, I think that's right. | |
Tweek: | Rrrrr! You guys never help me! [the parents look at each other, and Tweek starts banging his head against the table] Your stories never go anywhere! I hate it! I want out! I want out! [the parents resume eating] | |
[Craig's house, dinner time. Craig has a little sister] | ||
Craig: | Dad, I'm supposed to get in a fight tomorrow. | |
Dad: | With who? | |
Craig: | Some kid. | |
Dad: | Oh. | |
Mom: | Don't just "Oh" him, Thomas! | |
Craig: | Yeah, don't just "Oh" me! | |
Thomas | I'll "Oh" whoever I want! [Mom flips Thomas off, he flips back, the daughter flips them both off, and Craig flips his dad off with the right hand, his sister off with the left, and his mom with the right, up close] | |
[Mr. Adler's home. He and a woman have just returned from a date] | ||
Mr. Adler: | Well, that was fun, Pearl. See you later. | |
Pearl: | Richard, aren't you going to invite me in? | |
Mr. Adler: | Why? | |
Pearl: | Well, I thought maybe you would at least at-tempt to make love to me tonight. | |
Mr. Adler: | Oh, well, uuh, I can't. I left the oven on. | |
Pearl: | Oh, Richard, why can't you open your heart to me? Why? | |
Mr. Adler: | I just… I can't. Oh, I know. I have genital warts. [he begins closing the door] | |
Pearl: | We'll use plastic wrap. | |
Mr. Adler: | Nope. Sorry. Maybe some other time. [shuts the door on her face. He holds the door in place, then makes his way to a picture of his deceased love, picks it up, and remembers…] | |
Fiancée: | [on a swing] Swing me Richard, swing me higher. I wanna touch the sky, Richard. [now in a gazebo] Richard, I'm here! [waves him over] Smile. [now opens a little box and sees a ring] Oh, Richard, it's beautiful. Yes. Yes. [Now at a phone by a desk] But you have to come see me fly tomorrow, Richard. I have a surprise for you. [next day, next to a plane] Don't worry, Richard. I'll pilot! It's what I do! [in flight, trying to regain control] Aaaaaaa! [in a swimming pool, under water] Richard! [now rising from an open coffin] Richard. | |
Mr. Adler: | [returns] Haaarrr! [opens a small drawer in the side table, gets some nicotine gum, and starts chewing, then mumbles] Aw, God, what am I gonna do? [resumes chewing] | |
[South Park Elementary, the cafeteria, next day, recess. From left to right on a table are seated Stan, Tweek, Kyle, Cartman, Craig, and Kenny. Much of the class is assembled before them. A large sign saying "Tweek VS. Craig" hangs above them from the ceiling] | ||
Stan: | Okay, so, just to set the record straight here, the fight will be happening out by the tetherball pole at 3:30. Tweek just weighed in at 48 pounds, Craig at 45. | |
Clyde: | Uh, how long do you expect the fight to last? | |
Craig | I uh… | |
Cartman: | [covers Craig's mouth] However long Craig wants it to last. [the kids laugh] T'heh, ub. Look, make no mistake. Craig has been ready for this fight since day one. He doesn't even view it as a challenge. | |
Kyle: | He'll view it as a challenge when he's getting his ass kicked! | |
Cartman: | Hup. Did you hear that? It sound like some diarrhea coming out of someone's mouth or something. | |
Kyle: | Shut up, fatass!! | |
Cartman: | Don't call me fat, you son of a bitch! [jumps on him, and they start fighting. Kenny and Stan soon join in, leaving Tweek and Craig looking at them] | |
Clyde: | Wow. Tweek and Craig really hate each other, huh? This should be a good fight. | |
[Home Economics, after recess.] | ||
Pearl: | [stands by a chart equating shoes with money] On your first date, look at the man's shoes. Sometimes you can tell how much money a man has just by his shoes. [Kenny and the girls take notes. Pearl then stands by the chalkboard listing the number of credit cards from 1 to 4] When he takes you out to dinner, try to sneak a peek at his wallet while he pays for you. If he only has one credit card, BEWARE. [crosses 1 out] It means he doesn't spend a lot, and worse yet, it could be a debit card. If he has more than four credit cards, that's a little fishy. [crosses 4 out] The perfect number of credit cards for a man to have is… two. [circles it. Bebe raises her hand] | |
Bebe: | What if we meet a guy who wants to be a doctor or a lawyer, but is still getting his degree? | |
Pearl: | Dump that zero and get yourself a hero! He could be earning that degree all his life while you starve to death with two dying babies sucking at your teats. [the girls and Kenny just look at her] | |
[Shop class. The boys are busy on various projects. Cartman stands on a stool operating a drill press as Stan and Kyle stand on the floor.] | ||
Cartman: | When I have you guys' ten bucks, I'm gonna use it to buy the sweetest big-screen TV in the whole world. | |
Kyle: | That's more than ten bucks, you stupid fatass! | |
Cartman: | Well, if I get ten buck from each of you, that's like $2000 | |
Mr. Adler: | Hey, quit screwing around back there! You're horsing! [He now hears a voice calling to him, from the drawers in his desk…] | |
Fiancée: | Ri-chard! [he whistles] Ri-chard! [he remembers mumbling something in return, and pulls out her picture. He dreams: she is back on the swing] Swing me Richard, swing me higher! [now in a gazebo] Richard, I'm here! [waves him over. Cut to her opening a little box] Oh, Richard, it's beautiful. Yes. Yes. [Now at a phone by a desk] But you have to come see me fly tomorrow, Richard. I have a surprise for you. [next day, next to a plane] Don't worry, Richard. I'll pilot! [in the cockpit, she calls out] It's all for you! [an alarm sounds, and the gas tank explodes behind her] Aaaaaaa! [she tries to land the plane right, but it falls into a swimming pool. She's thrown clear, into the water] Richard! | |
Clyde: | Mr. Adler. Mr. Adler! | |
Mr. Adler: | [returns] Huh? Uh, what? | |
Clyde: | Tommy stuck his face in the belt sander [Tommy comes and stands beside Clyde. There are no features on his face.] | |
Mr. Adler: | The belt sander? Tommy?? I told you not to screw around with the belt sander, didn't I? [Clyde looks at Tommy for a reaction, but…] Well go on. Go see the nurse; she'll give you some peroxide. [Tommy walks away in the wrong direction] | |
Clyde: | [noticing the picture and points] What's that? | |
Mr. Adler: | Huh? Oh, this is a woman I knew a long time ago. | |
Clyde: | What? She die or something? | |
Mr. Adler: | What? Hey! Go on! [upset, he puts the picture away] You;'re screwing around in here! [Clyde hurries away] | |
[After school. The kids climb over a hill to reach the tetherball pole. Stan, Kyle, and Tweek lead the way] | ||
Clyde: | Oh boy! Here we go! | |
Wendy: | [joins the group] What's happening? | |
Kyle: | Tweek's gonna fight Craig! | |
Wendy: | Oh cool! | |
Stan: | Stay pissed, Tweek. Stay pissed. [the two groups meet] All right. Here we go. | |
Kyle: | Time for you to get proven wrong, fat boy | |
Cartman: | You're gonna be eating those words, asshole. | |
Kyle: | No I won't, because you'd eat 'em first, tubby. [Craig and Tweek look at each other, but nothing happens] | |
Stan: | Well? | |
Cartman: | Come on! | |
Wendy: | Yeah, if you're gonna do it, do it! | |
Craig: | [turns to the crowd] What do we do? | |
Stan: | Huh? | |
Cartman: | What do you mean, what do you do? You just fight each other. | |
Tweek: | How? | |
Kyle: | How?? | |
Craig: | I've never been in a fight before. | |
Tweek: | Me neither. | |
Crowd: | [let down] Awwww. | |
Stan: | [in disgust] Aw, dude, come on!! | |
Cartman: | You just hit each other, smack each other around. [Tweek slaps Craig, and Craig slaps Tweek. No effect] | |
Kyle: | [sighs] Not like that! | |
Tweek: | Like what, then? | |
Stan: | [approaches the fighters] All right, all right, screw it! We have to postpone the fight 'til Tweek and Craig can learn how to fight. | |
Crowd: | Awww. [disperses] | |
Clyde: | [to Wendy] All that build-up for nothing. | |
Wendy: | Yeah. Christ, I could have been home by now! | |
Stan: | All right. Tweek, we'll teach you how to fight, and Cartman, you teach Craig. | |
Cartman: | I don't think that's very fair: if I teach Craig, he's gonna really kill Tweek. | |
Stan: | Oh yeah? Well, I'm gonna have my uncle Jimbo teach Tweek how to box! | |
Cartman: | [faking fear] Ooooo! Boxing's scary, you guys! [serious] I'm gonna have Craig learn martial arts! | |
Stan: | Fine! We'll see you back here tomorrow! | |
Cartman: | Fine! [the parties part ways] | |
Kyle: | Fine! | |
Cartman: | Fine, that's fine! | |
[Big's Gym, later. This is where Stan and Kyle took Jesus to learn to box. Chef knocked him out with one blow. On this occasion, Stan and Kyle bring Tweek. Jimbo is the coach, Ned the sparring partner. All are in the ring] | ||
Jimbo: | Alrighty. Tweek, my little nephew Stanley has asked me to teach you the fine points of boxing. | |
Tweek: | Rrrrh! | |
Jimbo: | You're in luck! Ned here used to be the state champion until a grenade blew his arm off. | |
Ned: | Mmrr I can still kick ass. | |
Jimbo: | Now, Tweek, boxing is a Man sport. There is nothing in the world more Man than boxing. It is Man at his most Man. So when you spar with Ned here, just dig deep into that most Man part of you. | |
Tweek: | Hwaaah! [Stan and Kyle look at each other and shrug] | |
Jimbo: | Well, enough of the lectures. let's get to boxing. [rings the bell, and Ned sends Tweek to the ropes with one punch] | |
Tweek: | Uugh! | |
Ned: | Mmm whatcha got, bee-ahtch? [Tweek gets up] | |
Jimbo: | Keep your guard up, Tweek! [Tweek doez so. Ned punches him twice more, and Tweek falls] | |
Tweek: | Ow! | |
Stan: | Damnit! | |
Kyle: | Come on, Tweek! He's only got one arm! | |
Jimbo: | All right, looks like we'll have to apply the Oppenheimer technique with Tweek here. [Tweek gets up] | |
Ned: | [prancing] Gmmmmm, whatcha got, bee-ahtch? | |
Jimbo: | Punch him in the balls, Tweek!! [Tweek lunges at Ned and lands the punch] | |
Ned: | AAAAaaaarrgh. | |
Jimbo: | Atta boy! Now quick, get him again while he's down! [Tweek lands a barrage of punches, and Ned groans after each punch] | |
Ned: | Ow. | |
Jimbo: | Good! Now kick his balls! [Tweek does so several times, and Ned groans] There, see? You've got him coughing up blood. | |
Stan, Kyle: | Hooray! | |
Tweek: | Rrrr! | |
Jimbo: | Now THAT'S BOXING! | |
[The Nishimura School of Matial Arts] | ||
Master: | Your friend hasa brought you to learn the ancient art ofa sumo. You must learna discipline anda respect. [Craig flips him off] In sumo, your body must be rike a stone, and your mind rike a meatroaf. | |
Craig: | Meatloaf? | |
Master: | The object is simpry to push opponent out of circle. Is opponent ready? | |
Cartman: | I'm ready! [comes out, speaks softly] Hey, I like this hair thing. This is cool. [stops to pull some salt out of a kettle and pats his hands together] | |
Master: | Let us begin. [Cartman plants his feet] Ready? And, th-ree. | |
Cartman: | Respect my authoritah! [he and Craig engage in pushing each other] | |
Master: | Body rike a stone! Mind rike a meatroaf! | |
Cartman: | [turns around to back Craig out of the ring] Dude. Come on, now. Come on. | |
Craig: | Oh, Jesus! I can't take it! Stop! | |
Master: | Fight back! Resist the ass! | |
Craig: | How can I resist an ass so great? | |
Master: | It is only an ass. You must overcome the ass with your mind. | |
Craig: | This ass is umlike any I've encountered, Master. [Cartman bumps him off the ring, he hits a wall, and he's out] | |
Cartman: | I win! | |
Master: | There is indeed great power in your ass, Eric. Perhaps you should consider sumo as your profession. | |
Cartman: | Hey, may be. [plants his feet again] | |
[Mr. Adler's house, night. He's asleep, and a bad dream begins] | ||
Mr. Adler: | [twisting and turning] No. No. Make it stop. | |
Fiancée: | [laughing on the yard outside] Oh, Richard. Say you'll hold me forever. [Now at a phone by a desk] But you have to come see me fly tomorrow, Richard. I have a surprise for you. [next day, next to a plane] Don't worry, Richard. I'll pilot! [in the cockpit during flight] Watch me, Richard! [waves to him as shw writes "I love U Richard." As she gets to the latt letters, she loses control and the alarm comes on. Her gas tank explodes and she screams. She manages to write A's on her way down to a crash in the pool. She sinks and calls out] Richard! | |
Mr. Adler: | Baaaaa! [looks around and then sobs] I never got to say good-bye. I never got to say good-bye! [reaches for some nicotine gum, only to find the box empty] Oh no! Oh NO! NOW what do I do?! [begins bawling] | |
[South Park Elementary, next day. Home Ec.] | ||
Pearl: | Okay, that was very good, class. Now let's try this one together. [holds up a board saying] Honey, can I get a new wardrobe? | |
Class: | [including Kenny] Honey, can I get a new wardrobe? | |
Pearl: | All right, now let's try this one together. [holds up a board saying] Lisa Smith's husbamd just bought HER a new car.... | |
Class: | [including Kenny] Lisa Smith's husbamd just bought HER a new car.... | |
Pearl: | Good. Bebe, why don't you try this one. [holds up a board saying] I think a trip to Hawaii would really improve our sex life. | |
Bebe: | I think a trip to Hawaii would really improve our sex life. | |
Pearl: | Outstanding! Now, Kenny, how about you try? [holds up a board saying] I can't make love to you until we get a king-size bed. | |
Kenny: | (I can't make love to you until we get a king-size bed.) | |
Pearl: | [looks at him in dismay] O-kay. Kenny, could I talk to you over here real quick? | |
Kenny: | (Sure you can.) [gets up and goes to her desk] | |
Pearl: | Kenny, I don't know quite how to tell you this, but… I'm not sure home economics is right for you. | |
Kenny: | (Why?) | |
Pearl: | Well, your cooking is unsatisfactory, your sewing skills are below average, and, frankly, I don't think the odds of you marrying a nice rich man in the future are very, well, good. | |
Kenny: | (You don't?) | |
Pearl: | No. I think you should consider transfering to shop class. | |
Kenny: | (Shop class?) [images of threatening tools tools fill his head: a drill, a torch, a belt sander, a table saw] (No, I won't!) | |
Pearl: | Now, now. Very few students are severely innured in a shop class. | |
Kenny: | (I don't wanna take shop class!) [draws his hood tight, and the bell rings] | |
Bebe: | Come on! It's time for the fight! | |
Wendy: | Yeah! [the girls begin to file out of class] | |
Pearl: | Fight? Oh no no no, girls! Haven't I taught you anything? | |
[The playground, after school. The kids head for the tetherball pole. The fighters are present: Tweek wearing a boxing robe with hood, Craig in sumo gear] | ||
Stan: | Okay, the time has finally come. [the other kids close in] | |
Clyde: | [holding a box of] Programs, get your programs here. Programs. | |
Kyle: | Remember, Tweek: punch hard, punch low. | |
Tweek: | Hrrr. | |
Kyle: | This is when you gotta get mean, Tweek | |
Tweek: | Rrrr, mean, rrrr. | |
Cartman: | The spirit of the dragon is in your hands. Hurshar kashurshar. Hurlong churshar. All right? | |
Craig: | Okay. | |
Cartman: | Now, LISTEN to me! Hurlong kashurshar! All right?! And seriously: Hurlong kepur shung kwong! | |
Craig: | Okay, okay! | |
[Tweek is ready first, then Craig gets ready] | ||
Tweek: | Rrrr! [Craig adjusts his own head] Hr. [Craig flips him off] | |
Stan: | You ready Tweek? You ready Craig? Let's get in on! | |
Craig: | Respect my authority. | |
[Tweek lands some punches and Craig tries to throw Tweek off suno-style. They go back and forth this way for a while] | ||
Stan, Kyle: | Come on, Tweek! | |
Cartman: | Come on, Craig! | |
[The shop room. Mr. Adler is alone and starts to write]
| ||
Mr. Adler: | Good-bye, cruel world. [sits up] Jesus Christ! What was I thinking?! That would have hurt like hell! | |
[the playground. Craig and Tweek tumble towards the school, neither giving in. The other kids follow them to a clearing outside a bungalow, where Caraig and Tweek resume trading punches] | ||
Stan: | Ye-hah! | |
Cartman: | Come on, Craig! Time to kick his ass! [the fighters, now tired and panting, butt heads] | |
Kyle: | Go, Tweek. Kick his ass! Get him! | |
Cartman: | Come on, Craig! | |
Stan: | Come on, Tweek! You got him! | |
Kyle: | Get him! [the fighters just pant, stuck to each other] Whoa, Tweek! Did you hear that? | |
Tweek: | What? | |
Kyle: | Craig just called you a boner! | |
Tweek: | Rrrr! [punches Craig] | |
Kyle: | [to Stan:] He'll just have to keep throwing jabs to win the fight. | |
Stan: | Yeah. | |
[Shop class. Mr. Adler draws closer to the saw blade and sighs. Kenny comes in and hands him Pearl's note.] | ||
Kenny: | (Hi, Mr. Adler.) | |
Mr. Adler: | What? Who are you? [takes the note and reads]
| |
[Outside the bungalow Craig and Tweek continue fighting. They lock up and tumble into the slide, tearing it down. They end up under the debris] | ||
Tweek: | [gets up] Huh? [Craig pops up and tackles Tweek. The other kids, fearing the fight over, cheer again.] | |
[Shop Class. Kenny starts cutting wood on the jigsaw, but looks at Mr. Adler going to his death. Craig and Tweek crash through the shop class window and continue fighting] | ||
Mr. Adler: | [sits up] What the-? [the door opens and the other kids pour in] | |
Stan: | Here they are. | |
Mr. Adler: | [stands and walks towards the kids] Hey! What's going on? | |
Stan: | Tweek and Craig are fighting. We're just watching. [trading punches] | |
Mr. Adler: | Well, why the hell don't you stop them? | |
Cartman: | 'Cause we have ten bucks riding on it. | |
Mr. Adler: | Don't screw aROUND! [Craig and Tweek tumble towards Kenny] | |
Kenny: | (Hey!) [They knock the stool out under him. He hangs on to the jigsaw table] (Hey!) | |
Mr. Adler: | Stop screwin' aROUND!! [Tweek slams Craig into a second jigsaw and both tumble into a tool cart, which falls onto the second jigsaw, which tumbles onto the one Kenny is on.] | |
Kenny: | (Hey, God damnit!) | |
Mr. Adler: | Eh. Hey, you're SCREWIN' AROUND TOO MUCH!! [Kenny gets stuck in the blade and spins around. He's finally thrown clear and ends up in a box of old nails. Some nails fly out of the box.] | |
Kenny: | (Ugh!) | |
Stan: | Oh my God, they killed Kenny! | |
Kyle: | You bastards! | |
Mr. Adler: | [goes to the box of nails and plucks Kenny out] Well, don't just stand there, call an ambulance! [the boys just shrug] You see? You see what happens when you screw around in shop class? | |
Kenny: | (I understand, dude.) | |
Mr. Adler: | What? What's that, son? | |
Fiancée: | [through Kenny] Richard. | |
Mr. Adler: | AAaaagh! [settles down] No! No, please don't go. I need you. I can't live without you. [Stan and Kyle look at each other, Stan shrugs] | |
Fiancée: | [visible now, where Kenny's face was] Richard, you have to move on. I want you to be happy. | |
Mr. Adler: | But I can't. I never got a chance to say good-bye. | |
Fiancée: | Then say it now, Richard. | |
Mr. Adler: | Good-bye? | |
Fiancée: | There. Now do you feel better? | |
Mr. Adler: | No. | |
Fiancée: | Of course you don't. Saying good-bye doesn't mean anything. It's the time that we spent together that really matters, not how we loved it. | |
Mr. Adler: | You… you're right. You're right. [The fiancée leaves and an old woman takes her place. The background is blue.] | |
Woman: | Richard, this is Grandma. | |
Mr. Adler: | Gram'ma? Hi, Gram! | |
Gram'ma: | You never said good-bye to me either. [she leaves and a man enters] | |
Man: | Hey, Richard. Remember me? | |
Mr. Adler: | Uncle Corey! Wow, you're all alive again! | |
Uncle Corey: | [gleefully] No! We're dead! [leaves] | |
Fiancée: | [returns] I love you, Richard. See you soon. | |
Mr. Adler: | Thank you. Thank you for freeing me. I feel like now I can move on. Baby, I feel so much better. I feel so alive. [holds Kenny close] Thank you, baby. Thank you. | |
Stan: | Dude, this is pretty fucked up right here. | |
[Hell's Pass Hospital. The kids enter. Stan approaches a nurse] | ||
Stan: | Hi. We're here to visit our good friends, Tweek and Craig. | |
Nurse: | Oh. Well, I suppose a quick visit is okay. Maybe you kids can cheer them up. [leads the way. The kids follow and are let in. Craig and Tweek are in adjacent beds recovering from their injuries.] | |
Stan: | Hey, you guys. How are you feeling? | |
Tweek: | Rrr! | |
Craig: | Ugh. | |
Stan: | Well, uh. We just came by because we have something to tell you. | |
Kyle: | Yeah. See, we got you to fight just 'cause we wanted to see who was the toughest. We made up all that stuff we said to get you guys mad at each other. [Craig flips them off] | |
Cartman: | Yes. You can flip us off, Craig. We deserve that. We just came by to apologize. We feel so bad. | |
Kyle: | Boy, do we ever. | |
Stan: | So I guess we'll be gong now, and live with the knowledge that… you're both kind of sissies. [the group turns towards the door] | |
Tweek, Craig: | What?! | |
Stan: | [the group turns back to the beds] Well, I mean, that's what was on the news. | |
Craig: | What was on the news? | |
Cartman: | Oh, you didn't see it? Oh. Tweek's family was on the news saying what a wuss youare, Craig. | |
Craig: | Huh? | |
Kyle: | Yeah. And then Craig's family came on and said Tweek was the wuss, and then punched Tweek's mom in the hooters. | |
Tweek: | Uuh! You son of a bitch! [pounces on Craig, and the fighting starts again, leaving the room a mess] | |
Craig: | I'm gonna kick you ass! | |
Stan: | Come on, Tweek! You got him! | |
Cartman: | Give him sucky, Craig, give him sucky! Hurlong churshar! | |
[End of Tweek Vs. Craig] |


text:
5th Grade Summer Science Camps
2017 Applications
2017 Brochure
Camp hours are 9:00 a.m.— 3:00 p.m. daily. Camp Counselors
will be on duty beginning at 7:30 a.m. in the lobby of CHSB 19
(933-19th Street South) for early drop-off.
- Camps are offered alternating weeks.
- All children are required to bring a lunch daily except on Friday Pizza Day at the end of each week.
- Acceptance into CORD Camps will be based on available space and regional distribution of students.
- Children may attend Camp One and Camp Two.
- Tuition for the first week-long Camp is $175.00. Second Camp tuition is $75.
- A non-refundable deposit of $50 is required with application and will be applied toward total cost of tuition.
- Credit cards are not accepted for payment of tuition.
- All children will receive a Notification of Acceptance packet.
CORD 5th Grade Camps
CHSB 19, 5th Floor
933 19th Street South
Birmingham, AL 35294-2041
Fax # 205-934-5158

subset: commoncrawl


text:
Pool of Radiance
Published by Developed by Released Platforms |
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Located on the northern shore of the Moonsea in Forgotten Realms, Phlan was once a flourishing trade city. However, lately monsters began settling in it, gradually turning whole districts into ruins. Only New Phlan remained under human control, but its inhabitants are afraid to venture into the monster-infested areas. In order to clean the nearby Barren River and rebuild Phlan, local authorities spread rumors about alleged riches hidden somewhere in the city. A party of adventurers, attracted by these news, sails towards Phlan and accepts the quest.Pool of Radiance is the first adaptation of the Advanced Dungeons & Dragons role-playing system in a computer game format. In the beginning of the game the player can use a pre-made party of six characters or create each of them from scratch. Six races (human, elf, dwarf, gnome, halfling, and half-elf) and four classes (fighter, cleric, wizard, and thief) are available. The player can tweak the attributes of the characters and assign a moral alignment to each one.
Exploration of the town and hostile areas (dungeons) is viewed from a first-person perspective in a pseudo-3D world. Enemy encounters are random and take place on separate isometric combat screens, where player-controlled party and enemies take turns fighting each other. Experience points are awarded for defeating enemies, and characters level up after having accumulated set amounts. Fighters gain more attacks, thieves become proficient in backstabbing, while clerics and wizards can memorize more spells to cast before they need to rest. Non-human characters can also "multi-class" (learn the abilities of another class) when leveling up.
The NES version was substantially different from other versions. It removed references to the Adventure's Journal and some of the more complex features of the computer versions, like different currency units. Battles were significantly reduced in size, the graphics were overhauled and redesigned so that the game could be controlled with a control pad, and music was written for it. A randomly generated dungeon feature was also removed.
Promo Images
There are no promo images for this game
Alternate Titles
- "光芒之池" -- Chinese spelling (simplified)
- "Pool of Radiance - A Forgotten Realms™ Fantasy Role-Playing Epic, Vol. I" -- Tag-lined title
Part of the Following Groups
- Dungeons & Dragons Campaign Setting: Forgotten Realms
- Dungeons & Dragons (D&D / AD&D) licensees
- Fantasy Creatures: Elves
- Fantasy Creatures: Orcs
- Gameplay feature: Character development - Automatic leveling
- Games made into books
- Games with code-wheel copy protection
- Gold Box series
- Pool of Radiance series
User Reviews
Critic Reviews
Joystick (German) | Commodore 64 | Jan, 1989 | 9 out of 10 | 90 |
ASM (Aktueller Software Markt) | Commodore 64 | Oct, 1988 | 10.75 out of 12 | 90 |
100 aktuelle PC-Spiele | DOS | 1990 | 9 out of 10 | 90 |
Power Play | Amiga | Nov, 1990 | 85 out of 100 | 85 |
Power Play | DOS | Mar, 1989 | 84 out of 100 | 84 |
Power Play | Commodore 64 | Dec, 1988 | 82 out of 100 | 82 |
Zzap! | Commodore 64 | Dec, 1988 | 80 out of 100 | 80 |
Pixel-Heroes.de | Amiga | Apr, 2007 | 8 out of 10 | 80 |
Joker Verlag präsentiert: Sonderheft | Amiga | 1992 | 64 out of 100 | 64 |
Questicle.net | NES | Jan, 2011 | F | 0 |
Topic | # Posts | Last Post |
CCS64 loading | 7 | Pseudo_Intellectual (47942) Jul 20, 2010 |
Manual? | 1 | SharkD (418) Feb 23, 2010 |
This was the first Advanced Dungeons and Dragons (AD&D) game ever created by the software developer Strategic Simulations, Inc. (SSI). AD&D was originally a popular fantasy role playing game system developed by a company called TSR, Inc.. SSI adapted this role playing system to the PC in 1988. Pool of Radiance was also first of the many AD&D games to follow that are set within the Forgotten Realms. The game was so successful that it caused TSR to write a novel based on the story in the book.In the same year, SSI released two more of these newly developed AD&D PC games: Heroes of the Lance and Dungeon Masters Assistant Volume 1: Encounters.
Copy protection
This game used 2 forms of copy protection: Code Wheel lookup at start-up and a Journal to read important text passages.Cover art
The game box's cover features a painting by artist Clyde Caldwell, also used as the front cover to the 1989 novel of the same name as well as to the 1988 RPG module "Ruins of Adventure" inspiring both.Monster portraits
Many of the monster illustrations of the Macintosh version can be found in one of the AD&D 2nd edition accessories, the Monstrous Compendium Volume One.Other ports
An Atari ST conversion was advertised, but is generally considered vaporware, the strongest indication probably being the lack of an import option of Pool of Radiance characters in the sequel (Curse of the Azure Bonds) which the other versions offer.A port for the Apple IIGS was also advertised, solid evidence that it was released has yet to emerge.
- GameStar (Germany)
- Issue 12/1999 - #49 in the "100 Most Important PC Games of the Nineties" ranking
Related Web Sites
- Commodore 64 Boxed Sets (For C64: game packaging digitalisations. Include box, manual, brochure, additional material.)
- DOSBox, an x86 emulator with DOS (Compatibility information page about the original game and its DOSBox versions. )
- Dragonbait's Pool of Radiance Page (A walkthrough with images.)
- Fan Site (Pool of Radiance fan sight)
- Hall of Light (For Amiga: game database entry; digitalised manuals; game packaging; screenshots; additional material.)
- Lemon 64 (For Commodore 64: game entry database; advertisement; magazine reviews; music; documentation; cover art; additional material.)
- Macintosh Garden, an abandonware games archive (For Macintosh: reviews; game packaging; downloadable releases; manual; screenshots; additional material.)
- Museum of Computer Adventure Game History (Amiga) (For Amiga: game packaging; manuals; media; additional material.)
- Museum of Computer Adventure Game History (C64) (For Commodore 64: game packaging; manuals; media; additional material.)
- Museum of Computer Adventure Game History (Clamshell, C64) (For Commodore 64: game packaging; manuals; media; additional material.)
- Museum of Computer Adventure Game History (FCI, NES) (For Nintendo: game packaging; manuals; media; additional material.)
- Museum of Computer Adventure Game History (PC) (For IBM PC: game packaging; manuals; media; additional material.)
- Museum of Computer Adventure Game History (Pony Canyon, NES) (For Famicom: game packaging; manuals; media; additional material.)
- Pool of Radiance at Game Banshee (Walkthrough, screenshots, information, additional material.)
- Replacementdocs (C64, Quick Reference Card) (Documentation for Commodore 64.)
- Replacementdocs (PC, Adventurers Journal) (Documentation for DOS/Windows.)
- Replacementdocs (PC, Cluebook) (Documentation for DOS/Windows.)
- Replacementdocs (PC, Code Wheel) (Documentation for DOS/Windows.)
- Replacementdocs (PC, Manual) (Documentation for DOS/Windows.)
- Replacementdocs (PC, Quick Reference Card) (Documentation for DOS/Windows.)
- Wikipedia, the free encyclopedia (Encyclopaedic entry for combined platforms.)
Amiga Credits
Additional graphics:
Scenario created by TSR, Inc.:
Game Created by:
Additional Programming:
Additional graphics:
Scenario created by TSR, Inc.:
Game Created by:
SSI Special Projects Group
Programmers:Additional Programming:


text:
NEW PRODUCT! Adafruit Beginner LED Sewing Kit – Add LED accents to textile projects with Adafruit's LED Sewing Kit! Stitch a glowing circuit with conductive thread– this kit comes with everything you need to get started:
- 1 bobbin of 2-ply conductive thread
- 2 x sewable CR2032 battery holders
- 2 x CR2032 batteries
- 4 x candle flicker LEDs – they twinkle automatically, no need for a microcontroller or external circuit!
- 4 x 5mm snaps to use as as sewable switches
- Needle set
This kit comes with enough supplies to make two projects with two LEDs each, or one project with four LEDs. Great for embroidery and needlework, light-up jewelry and hair accessories, shoes, plush toys, and more. This is a great beginner kit for kids (no soldering!) and adults alike who are looking to get into soft circuits and wearable electronics.
Check out our guide for the LED Sewing Kit on the Adafruit Learning System!
Learn to make a Candle Flicker Hairbow with our project tutorial!
Check out all the Circuit Playground Episodes! Our new kid's show and subscribe!
Have an amazing project to share? Join the SHOW-AND-TELL every Wednesday night at 7:30pm ET on Google+ Hangouts.
Join us every Wednesday night at 8pm ET for Ask an Engineer!
Learn resistor values with Mho's Resistance or get the best electronics calculator for engineers "Circuit Playground" – Adafruit's Apps!
Maker Business — SoftBank Invests $300 Million in WeWork
Wearables — Wood paint
Electronics — What's in a diode?
Biohacking — Altra IQ – The Running Coach in a Shoe
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text:
Wednesday, August 22, 2012
My Space @ The Vintage Bazaar, Chicago
23 comments:
- Vintage Market Place said...
Ooo it looks adorable!!!
I am loving those little red shoes. Did they sell?
So glad to hear ya did so well.
Amy - August 22, 2012
- Ruby Jean said...
It all looks so FUN and certainly Pretty!! Congratulations on your sales. I was actually absent from blogging myself and have only recently come back. So it's good to see you again!
Angelina - August 22, 2012
- Junkchiccottage said...
Ohhhh Stacey love all the pictures. What cute stuff. I want one of those vintage trailers too for my backyard. So so cute. I have been looking for awhile and they are hard to come by. I love your signs too. All looks so cute.
Kris - August 22, 2012
- birdie blue said...
so fun to see pics of your set-up, stacey. would've loved to stop by, but ended up spending the day on lake michigan/boat with the girls. next time!
someone was selling a cute camper up near madison, it was on craigslist. not sure if it sold...
molly - August 22, 2012
- Cassie @ Primitive & Proper said...
oh i love your space! so cute and happy and colorful!
- August 22, 2012
- Cozy Little House said...
That was a fun tour, Stacey! Thanks for taking me along.
Brenda - August 22, 2012
- Debby said...
Oh that looks like fun. I want one of those vintge trailers as well. So cute, aren't they.
- August 22, 2012
- Into Vintage said...
Thanks for sharing this -- I love to see how other sellers set up. Wish I could have been there to shop!
- August 22, 2012
- Shanon at Vintage Sparkle Chic said...
What a fun place to shop! I'm so glad for you that most of your goodies were sold. Love those vintage trailers, too.
~Shanon - August 22, 2012
- Urban Farmgirl said...
How fun! For sure a fun, hip vintage-mod kind of show...love it! You booth had such great color! Would have sucked me in right away! ;o)
Mary - August 22, 2012
- Urban Farmgirl said...
How fun! For sure a fun, hip vintage-mod kind of show...love it! You booth had such great color! Would have sucked me in right away! ;o)
Mary - August 22, 2012
- michele said...
looks so fun, stacey. i bet you will have your trailer someday soon!
michele - August 22, 2012
- Holly- Cutie Pie Cottage said...
Ooo! I see you had some Alpine glassware. I collect Alpine/Challet because my mom did when I was very young. Seeing it reminds me of her. she was blue/green about everything for years! I'm tired of dark blues and greens but the light blue in the pattern is perfect.
I'm glad you sold so much stuff! I was thinking about those little touches you girls added like the red dotty ribbon on the bike. What an eye catcher. Good job! ♥ - August 23, 2012
- traci said...
great booth stacey. so bright and fun. i am glad you did well.
- August 23, 2012
- Tricia said...
You booth looks like it was jam-packed with great stuff! I'm glad the day went well for you :)
- August 23, 2012
- michele said...
i'm back with a link to share because i instantly thought of you when i saw these stools on a bloggy friend's blog. they are rustic with a vintage crocheted top:
you could make these and they could be lovely!
michele - August 23, 2012
- Vickie @ Ranger 911 said...
What fabulous treasures in your booth!!! I've got to go back and look again.
- August 24, 2012
- Jill Flory of Sew a Fine Seam said...
Awesome! I would loved to have shopped there! and yes, the campers are just too cute! Hope you find one soon!
- August 24, 2012
- LANA said...
Just blog when you can. You are out there living life! Love the photos of the vintage goodies.
- August 26, 2012
- Keeping it Cozy said...
How FUN! Love those vintage trailers and your space looks fabulous.
- August 27, 2012
- Little Susie Home Maker said...
Looks like a lot of fun! So glad you did well!
Susie - August 27, 2012
- Elyse said...
look at your tags! look at the paint stirrers! love it all!
elyse - August 29, 2012
- {northern cottage} said...
ackkk - completely darling...I think if I'd been able to attend I might have just bought every.single.little.thing! um yeah and if I were rich! shucks - I need that combo!
- September 11, 2012


text:
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While our main goal is to spay or neuter un-owned cats, the Companion Cats' spay/neuter clinic is also a no-kill shelter licensed through the State of Michigan. Unfortunately, like most shelters, our space is very limited. While we do offer shelter for un-owned friendly cats and kittens waiting for new homes, we can only take additional cats as space allows. Please be aware, we do have a long waiting list at this time. To be added to the waiting list please call 269-753-5594 and leave a detailed message.
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text:
Freeman, Ralf
fl. 1807–31
Ralf Freeman, Baptist minister, was born a slave in Anson County; his parents are not known. He belonged to John Culpeper, a Baptist minister and pastor of the Rocky River Baptist Church, Anson County. Most of the information concerning this early black pastor comes from George W. Purefoy's history of the Sandy Creek Baptist Association. Freeman was probably baptized by the Rocky River Baptist Church, of which he became a member. Within a short time, when it was discovered that he had the ability to preach, he was licensed by the church. Soon afterward he was ordained and began to preach in the counties of Moore, Randolph, and Davidson.
In 1801, John Culpeper was elected a member of the North Carolina House of Commons from Anson County. In 1806, he won election to the U.S. House of Representatives from the Seventh District, serving in 1807–9, 1813–17, 1819–21, 1823–25, and 1827–29. When he rode off to Washington, he left the church and congregation of Rocky River in the hands of his servant Ralf, who then began his own years of service to the church. In imitation of John Culpeper, his preaching was forceful, his faith firm, and he handled his master's flock with unusual ability. He officiated at sacraments and burials, made pastoral calls, and attended to numerous church duties. He was also frequently called upon to preach at the annual meetings of the Pee Dee Baptist Association and was held in high regard by all who knew him.
Freeman served as a delegate from Rocky River to the Sandy Creek Baptist Association in the period 1807–10. In 1809, he was listed as "Elder Ralf (a colored minister)." In 1811, he was a delegate from the Sandy Creek Baptist Association to the Raleigh Baptist Association. At this session he was listed as "Elder Ralf Freeman." Before then he had been listed as "Ralf" with no surname. Thus he evidently received his freedom sometime during 1810–11. He continued to represent the church as a delegate through 1814. He also preached the Sunday sermon at the Sandy Creek Association in 1809 and 1814. Purefoy says that he was a good reader and was well read in the Scriptures.
The earliest minutes of Rocky River Baptist Church are for 5 Apr. 1828, when Ralf Freeman was in attendance and led the church in prayer. He was also listed in the black male section of the church roll for 1828. In May 1828 he assisted in the establishment of the Brown Creek Baptist Church. That fall he was elected as a delegate to the Pee Dee Baptist Association. In May 1830 he helped organize the Kendalls Baptist Church, and in July of the same year he was appointed to attend to the constitution of the arm of the Fork of Little River at Suggs Creek.
Purefoy described Freeman as being of common size, "perfectly black," with a smiling countenance, especially when conducting religious services. One writer recorded that "he would have no money for preaching; he only wanted food and clothing." At the session of the Pee Dee Baptist Association held with the church at Elizabeth, a preacher from Charleston, S.C., recommended that Freeman give the Sunday sermon. He had heard of Ralf and had come to hear him preach. Freeman did preach on "The Temptation of Christ." In the middle of the sermon he read the passage, "All these things will I give thee"; then, smiling at the congregation, he said, "Poor devil, he didn't have a foot of land in the world."
Freeman became a close friend of Elder Joseph Magee, a Baptist minister. They preached and traveled together, and both agreed that the survivor would preach at the other's funeral. Magee moved to Tennessee and died first. At his death he bequeathed to Freeman his riding horse, overcoat, Bible, and fifty dollars in cash; he also requested that Freeman preach at his funeral. In company with a white brother, Freeman rode to Tennessee to carry out the wish of his friend. At the conclusion of his sermon the congregation contributed fifty dollars to his support.
The career of this gifted individual was darkened near its end in the aftermath of the Nat Turner insurrection in Southampton County, Va., in 1831, when restrictions on slaves and free blacks were tightened. They were forbidden to preach or exhort in public or in any way officiate as preacher or teacher at prayer meetings or meetings for worship where slaves of different masters were collected.
The last record of Freeman is in 1831. According to one writer it is probable that Freeman died in the fellowship of the Primitive or Antimission Baptists, but this was more by accident than by choice. When the arm of Rocky River at Bethlehem (near Ansonville) became a regular church in March 1831, Freeman moved his membership there. The church later became Primitive and soon afterward extinct. Freeman was buried in the church cemetery by his white friends and a small stone was placed at the head of his grave. In 1907, this was replaced by a more substantial memorial marker.
Freeman's wife was probably named Genny, (as listed in the 1828 church roll). Their daughter, Judy, married Abraham McRae. Abraham and Judy had a daughter, Sarah Jane, who became the wife of Allen Ratliff and the mother of William Martin Ratliff.
E. M. Brooks, History of Rocky River Baptist Church (1928).
Ralf Freeman biography folder (Baptist Historical Collection, Wake Forest University, Winston-Salem).
Additional Resources:
"Ralf Freeman." N.C. Highway Historical Marker K-57, N.C. Office of Archives & History. http://www.ncmarkers.com/Markers.aspx?sp=Markers&k=Markers&sv=K-57 (accessed February 28, 2014).
North Carolina General Assembly. Journals of the Senate and House of Commons of the General Assembly of North-Carolina at its session in 1832/1833. Raleigh [N.C.]: Charles R. Ramsay, Printer to the State. 1833. 30, 39, 166, 182, 199. http://digital.ncdcr.gov/cdm/ref/collection/p249901coll22/id/489435 (accessed February 28, 2014).
Coon, Charles L. "4. Ralph Freeman Must Not Preach." Beginnings of Public Education in North Carolina, A Documentary History, 1790-1840, Vol. 2. Raleigh [N.C.]: Edwards & Broughton Printing Co. 1908. 536-537. http://digital.ncdcr.gov/cdm/ref/collection/p249901coll22/id/333747 (accessed February 28, 2014).
1 January 1986 | Woodard, John R.
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What can be used to intercept a telephone conversation?
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Groups like the government use satellite's to tap in. When a phone call is made, the signal is sent out through satellite's, all the government has to do is have the sigal also "bounce" to them. This however is illegal, as the law is set up the at least one person using the phone (the caller or the one being called).
There are also "bugs" that can be added to a phone, these are harder to set up ,as you need to get ahold of the phone, place the bug, and leave it. These are also alittle easier to find.


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The Apocalypse mod has been updated at the fan's request to fully support the single player campaigns.
XML file for Soviet Stealth Bomber. I posted this because it was requested by a modder. If anyone wants to know about the main file's related content...
This unit's working art code as used in the Red Star mod.
I've resumed working on the mod. Rebuild for 1.12 and added new unit.
Added Soviet Grinder Tank, Soviet War Mammoth and Empire Shogun Guardian.
The full source code for the Mammoth demo mini-mod.
Soviet Mammoth Tier 3+ unit demonstration (fully functional)
Added Soviet Saboteur and Soviet Stealth Bomber (sounds also have been included).
No construction limitation for advanced base defenses. Updated for version 4.0 of the mod.
Added Empire Ghost Plane. Added new sounds for the new units.
Added Rocket Warrior as early infantry Empire AA unit. Added Empire Air Tower. Fixed remaining small bugs from 1.6.
Two new units have been added for Empire: Kink Oni Prototype and Kamikaze Emperor Clone. The critical Allied Naval Yard bug in beta 1.2 has been fixed.
This version fixes all the issues in beta 1. - Fixed Tech Tree Dependencies - Fixed Soviet Power Plant Dependencies for all Structures - Fixed Tesla Tank...
This is the first beta of the Red Star mod. Some of the intended changes have been fully implemented. Now I'll start to add new units and support powers...
Major change: implemented new Tech Tree for all 3 sides.
The changes are not by far final; balance changes will be final only after the totally new tech tree will be implemented for all sides.
This is the complete source code for my C&C3 Termination mod. A lot of modders asked how I did various stuff in this mod. Now they have the chance to...
This file makes Red Alert 2 and Yuri's Revenge work on LAN even if you don't have IPX/SPX installed. IPX/SPX can be installed in XP, but not in Vista...
Latest version of the mod, in .zip format. Read the .txt file for more info.
This is the whole mod. Follow the instructions in the .txt to install it.
This is the actual mod, full version (v3.0), in WinRAR SFX format. Just install the mod in your Starfleet Command 3 folder.


text: In early February the stock market was trading off its recent highs. Gold had pulled back substantially, and most other commodities were taking a hit as the U.S. dollar rose. However, one commodity has been able to shrug off the selling and hit a fresh two-year high in February – timber. Price Of Lumber Highest Since 2007 – The price of timber rose above $280 per 1,000 board feet in February, the highest since August 2007. And in the last year, the commodity is up approximately 60%, slightly ahead of U.S. equities. The rise in lumber is confusing to many because the housing market has yet to show sustainable recovery signs. Considering the housing sector is responsible for 45% of the lumber demand, according to the Western Wood Products Association, the rise in timber can suggest a few things. For starters, the rise in timber could be a leading indicator that the housing market is about to turn, as the commodity's price rises before the next demand surge. On the other hand, the price increase could be tied to the fact that timber supply has dropped dramatically, as less was produced during the recession. Finally, it could be that lumber is rising with every other commodity and asset class off the March lows after investors priced in a depression scenario that never occurred. Read More


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My girls sit here in the office with me while they do their homework. I was busy doing something on the computer and noticed that Gwen was especially quiet so I glanced over at her and this is what I saw. Aren't they cute when they're asleep?
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Thursday, January 11, 2007
Six pages...
...of a book I'm sending in soon. This is the way it starts. No text in the beginning, just a strange dude on a bike making a delivery. I'm watching too many Sergio Leone movies lately.
Somebody on the "Wisen" board mentioned they'd like to see sketches and I think that's a fun idea.
5 comments:
- Tom GoldsmithJanuary 11, 2007 at 2:49 PM
Great work. I am a huge fan of prelims. I love the blood and guts of the process. Keep'em coming.
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Adopt or next cats on Catroulette
Simple. Cute. Possibly very effective. Catroulette is a website that offers the opportunity to adopt homeless cats. Freely inspired to the chat roulette concept, the website showcases random short videos of cats available for adoption in Belgium. Check it out here
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Marcelo Balboa
Hall of Fame Class of 1995 U.S. Soccer magazine male athlete of the year in 1994...Member of the 1990 and 1994 World Cup teams...A first-team and second-team All-American at San Diego State. Was one of the nation's top tem collegiate players in 1988 according to Soccer America...Went on to become a standout professional in the United States and Mexico. |


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Happy Father's Day to all the dad's out there! Hope everyone has a fabulous day with their dad.
Here is a card I made with the amazing photopolymer stamp sets. I love the new Show & Tell sets.
Here are the ingredients to make the card:
Stamp Sets: Show & Tell 1 & 2, Designer Typeset, Something to Celebrate
Ink: Pacific Point, Coastal Cabana, Midnight Muse
Paper: Whisper White, Midnight Muse Patterns Designer Series Paper, Costal Cabana Patterns Designer Series Paper
Accessories: Silver Brads from a local craft stoe, Silver Designer Buttons
Tools: 1 3/4" Circle Punch, Corner Rounder from a local craft store
Saturday, June 15, 2013
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Also Known AsRoot Ginger, Gingembre, Adrak, InjiDescriptionIt is the underground stem/ tuber of the ginger plant which was originally cultivated in Asia. This rhizome is now grown in West Africa, the Caribbean etc. It is used in various forms like fresh, tender, dried, crystallized and in the powder form. In Asian cooking, ginger is almost always used minced, crushed or sliced.
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出典: meddic
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/02 23:31:58」(JST)
wiki en
[Wiki en表示]Systematic (IUPAC) name | |
(RS)-3-(4-Amino-1-oxo 1,3-dihydro-2H-isoindol- 2-yl)piperidine-2,6-dione
Clinical data | |
Trade names | Revlimid |
AHFS/Drugs.com | monograph |
MedlinePlus | a608001 |
Pregnancy category |
Legal status |
Routes of administration |
Oral |
Pharmacokinetic data | |
Protein binding | 30% |
Metabolism | Undetermined |
Biological half-life | 3 h |
Excretion | Renal (67% unchanged) |
Identifiers | |
CAS Number | 191732-72-6 Y |
ATC code | L04AX04 |
PubChem | CID 216326 |
DrugBank | DB00480 Y |
ChemSpider | 187515 Y |
ChEMBL | CHEMBL848 Y |
Chemical data | |
Formula | C13H13N3O3 |
Molar mass | 259.261 g/mol |
(verify) |
Lenalidomide /ˌlɛnəˈlɪdoʊmaɪd/ (trade name Revlimid) is a derivative of thalidomide introduced in 2004.
It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic treatment. Lenalidomide has also shown efficacy in the class of hematological disorders known as myelodysplastic syndromes (MDS). Along with several other drugs developed in recent years, lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users. [1] It costs $163,381 per year for the average patient.[2]
- 1 Medical uses
- 1.1 Multiple myeloma
- 1.2 Myelodysplastic syndromes
- 1.3 Other cancers
- 2 Adverse effects
- 2.1 Venous thromboembolism
- 2.2 Stevens-Johnson syndrome
- 2.3 FDA ongoing safety review
- 3 Mechanism of action
- 4 Synthesis
- 5 Price
- 6 See also
- 7 References
- 8 Further reading
- 9 External links
Medical uses
Multiple myeloma
Multiple myeloma is a cancer of the blood, characterized by accumulation of a plasma cell clone in the bone marrow.[3] Lenalidomide is one of the novel drug agents used to treat multiple myeloma. It is a more potent molecular analog of thalidomide, which inhibits tumor angiogenesis, tumor secreted cytokines and tumor proliferation through the induction of apoptosis.[4][5][6]
Compared to placebo, lenalidomide is effective at inducing a complete or "very good partial" response as well as improving progression-free survival. Adverse events more common in people receiving lenalidomide for myeloma were neutropenia (a decrease in the white blood cell count), deep vein thrombosis, infections, and an increased risk of other hematological malignancies.[7] The risk of second primary hematological malignancies does not outweigh the benefit of using lenalidomide in relapsed or refractory multiple myeloma.[8] It may be more difficult to mobilize stem cells for autograft in people who have received lenalidomide.[9]
On 29 June 2006, lenalidomide received U.S. Food and Drug Administration (FDA) clearance for use in combination with dexamethasone in patients with multiple myeloma who have received at least one prior therapy.[10]
On 23 April 2009, The National Institute for Health and Clinical Excellence (NICE) issued a Final Appraisal Determination (FAD) approving lenalidomide, in combination with dexamethasone, as an option to treat patients who suffer from multiple myeloma who have received two or more prior therapies in England and Wales.[11]
On 5 June 2013 the FDA designated lenalidomide as a specialty drug requiring a specialty pharmacy distribution for "use in mantle cell lymphoma (MCL) in patients whose disease has relapsed or progressed after 2 prior therapies, 1 of which included bortezomib." Revlimid is only available through specialty pharmacy, "a restricted distribution program in conjunction with a risk evaluation and mitigation strategy (REMS) due to potential for embryo-fetal risk."[12]
Myelodysplastic syndromes
With myelodysplastic syndromes (MDS), the best results of lenalidomide were obtained in patients with deletion 5q.[13]
It was approved by the FDA on December 27, 2005 for patients with low or intermediate-1 risk MDS with 5q- with or without additional cytogenetic abnormalities. A completed Phase II, multi-centre, single-arm, open-label study evaluated the efficacy and safety of Revlimid monotherapy treatment for achieving haematopoietic improvement in red blood cell (RBC) transfusion dependent subjects with low- or intermediate-1-risk MDS associated with a deletion 5q cytogenetic abnormality.
63.8% of subjects had achieved RBC-transfusion independence accompanied by a median increase of 5.8 g/dL in blood Hgb concentration from baseline to the maximum value during the response period. Major cytogenetic responses were observed in 44.2% and minor cytogenetic responses were observed in 24.2% of the evaluable subjects. Improvements in bone marrow morphology were also observed. The results of this study demonstrate the efficacy of Revlimid for the treatment of subjects with Low- or Intermediate-1-risk MDS and an associated del 5 cytogenetic abnormality.[13][14][15]
Lenalidomide was approved on June 17, 2013 by the European Medicines Agency for use in low- or intermediate-1-risk myelodysplastic syndromes (MDS) patients who have the deletion 5q cytogenetic abnormality and no other cytogenetic abnormalities, are dependent on red blood cell transfusions, and for whom other treatment options have been found to be insufficient or inadequate.[16]
Other cancers
Lenalidomide is undergoing clinical trial as a treatment for Hodgkin's lymphoma,[17] as well as non-Hodgkin's lymphoma, chronic lymphocytic leukemia and solid tumor cancers, such as carcinoma of the pancreas.[18] One Phase 3 clinical trial being conducted by Celgene in elderly patients with B-cell chronic lymphocytic leukemia was halted in July 2013 when a disproportionate number of cancer deaths were observed during treatment with lenalidomide versus patients treated with chlorambucil.[19]
Adverse effects
Lenalidomide is related to thalidomide which is known to be teratogenic. Tests in monkeys have suggested lenalidomide is also teratogenic.[20] It therefore has the pregnancy category X and cannot be prescribed for women who are pregnant or who might be conceiving. For this reason, the drug is only available in the United States (under the name Revlimid) through a restricted distribution system called RevAssist.
Other potential side effects are thrombosis, pulmonary embolus, and hepatotoxicity, as well as bone marrow toxicity resulting in neutropenia and thrombocytopenia. Myelosuppression is the major dose-limiting toxicity, which is contrary to experience with thalidomide.[21]
Venous thromboembolism
Lenalidomide, like its parent compound thalidomide, may cause venous thromboembolism (VTE), a potentially serious complication with their use. Bennett et al. have reviewed incidents of lenalidomide-associated VTE among patients with multiple myeloma.[22] They have found that there are high rates of VTE when patients with multiple myeloma received thalidomide or lenalidomide in conjunction with dexamethasone, melphalan, or doxorubicin. When lenalidomide and dexamethasone are used to treat multiple myeloma, a median of 14% of patients had VTE (range,3-75%). Patients who took prophylaxis to treat lenalidomide-associated VTE, such as aspirin, thromboembolism rates were found to be lower than without prophylaxis, frequently lower than 10%. Clearly, thromboembolism is a serious adverse drug reaction associated with lenalidomide, as well as thalidomide. In fact, a black box warning is included in the package insert for lenalidomide, indicating that lenalidomide-dexamethasone treatment for multiple myeloma is complicated by high rates of thromboembolism.
Currently, clinical trials are underway to further test the efficacy of lenalidomide to treat multiple myeloma and how to prevent the lenalidomide associated venous thromboembolism.
Stevens-Johnson syndrome
In March 2008, the U.S. Food and Drug Administration (FDA) included lenalidomide on a list of 20 prescription drugs under investigation for potential safety problems. The drug is being investigated for possibly increasing the risk of developing Stevens–Johnson syndrome, a life-threatening condition affecting the skin.[23]
FDA ongoing safety review
As of 2011, the FDA has initiated an ongoing review of Revlimid. The review focuses on clinical trials which found that Revlimid caused an increased risk of developing new malignancies such as acute myelogenous leukemia (AML) and B-cell lymphoma.[2] The FDA is currently advising all patients on Revlimid to continue their treatment.[24]
Mechanism of action
Lenalidomide has been used to successfully treat both inflammatory disorders and cancers in the past 10 years. There are multiple mechanisms of action, and they can be simplified by organizing them as mechanisms of action in vitro and in vivo.[25]In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of angiogenesis, and immunomodulatory role. In vivo, lenalidomide induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity. Lenalidomide has a broad range of activities that can be exploited to treat many hematologic and solid cancers.
On a molecular level, Lenalidomide has been shown to interact with the ubiquitin E3 ligase Cereblon[26] and target this enzyme to degrade the Ikaros transcription factors IKZF1 and IKZF3.[27] This mechanism was unexpected as it suggests that the major action of lenalidomide is to re-target the activity of an enzyme rather than block the activity of a enzyme or signaling process and thereby represents a novel mode of drug action. A more specific implication of this mechanism is that the teratogenic and anti-neoplastic properties of lenalidomide, and perhaps other thalidomide derivatives, might be dissociated.
The low level of research that continued on thalidomide, in spite of its ill repute, unexpectedly showed that the compound affected immune function. The drug was, for example, recently approved by the FDA for treatment of complications from leprosy; it has also been investigated as an adjunct for treating some malignancies. Recent research on related compounds has revealed a series that inhibits tumor necrosis factor (TNF-α).
In 2013 the UK National Institute for Health and Care Excellence (NICE) rejected lenalidomide for "use in the treatment of people with a specific type of the bone marrow disorder myelodysplastic syndrome (MDS)" in England and Scotland, arguing that Celegene "did not provide enough evidence to justify the £3,780 per month (USD$5746.73) price-tag of lenalidomide for use in the treatment of people with a specific type of the bone marrow disorder myelodysplastic syndrome (MDS)".[29] Revlimid made almost $3.8bn for Celgene in 2012.[29]
See also
- Discovery and development of thalidomide and its analogs
- ^ McCarthy PL, Owzar K, Hofmeister CC, Hurd DD, Hassoun H, Richardson PG, Giralt S, Stadtmauer EA, Weisdorf DJ, Vij R, Moreb JS, Callander NS, Van Besien K, Gentile T, Isola L, Maziarz RT, Gabriel DA, Bashey A, Landau H, Martin T, Qazilbash MH, Levitan D, McClune B, Schlossman R, Hars V, Postiglione J, Jiang C, Bennett E, Barry S, Bressler L, Kelly M, Seiler M, Rosenbaum C, Hari P, Pasquini MC, Horowitz MM, Shea TC, Devine SM, Anderson KC, Linker C (2012). "Lenalidomide after stem-cell transplantation for multiple myeloma". N. Engl. J. Med. 366 (19): 1770–81. doi:10.1056/NEJMoa1114083. PMC 3744390. PMID 22571201.
- ^ a b Badros, Ashraf Z. Badros (May 10, 2012). "Lenalidomide in Myeloma — A High-Maintenance Friend". N Engl J Med 366 (19): 1836–1838. doi:10.1056/NEJMe1202819. PMID 22571206.
- ^ Armoiry X, Aulagner G, Facon T (June 2008). "Lenalidomide in the treatment of multiple myeloma: a review". Journal of Clinical Pharmacy and Therapeutics 33 (3): 219–26. doi:10.1111/j.1365-2710.2008.00920.x. PMID 18452408.
- ^ Li S, Gill N, Lentzsch S. Recent advances of IMiDs in cancer therapy. Curr Opin Oncol. 2010 Nov;22(6):579-85. doi: 10.1097/CCO.0b013e32833d752c. Review.PubMed PMID 20689431.
- ^ Tageja N. Lenalidomide - current understanding of mechanistic properties. Anticancer Agents Med Chem. 2011 Mar;11(3):315-26. Review. PubMed PMID 21426296.
- ^ Kotla V, Goel S, Nischal S, Heuck C, Vivek K, Das B, Verma A. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36. doi: 10.1186/1756-8722-2-36. Review. PubMed PMID 19674465; PubMed Central PMCID: PMC2736171.
- ^ Yang, B; Yu, RL; Chi, XH; Lu, XC (2013). "Lenalidomide treatment for multiple myeloma: systematic review and meta-analysis of randomized controlled trials.". PLoS ONE 8 (5): e64354. doi:10.1371/journal.pone.0064354. PMC 3653900. PMID 23691202.
- ^ Dimopoulos, MA; Richardson, PG; Brandenburg, N; Yu, Z; Weber, DM; Niesvizky, R; Morgan, GJ (Mar 22, 2012). "A review of second primary malignancy in patients with relapsed or refractory multiple myeloma treated with lenalidomide.". Blood 119 (12): 2764–7. doi:10.1182/blood-2011-08-373514. PMID 22323483.
- ^ Li, Shirong; Gill, Navkiranjit; Lentzsch, Suzanne (November 2010). "Recent advances of IMiDs in cancer therapy". Current Opinion in Oncology 22 (6): 579–585. doi:10.1097/CCO.0b013e32833d752c. PMID 20689431.
- ^ "FDA approves lenalidomide oral capsules (Revlimid) for use in combination with dexamethasone in patients with multiple myeloma". FDA. 2006-06-29. Retrieved 2015-10-15.
- ^ "REVLIMID Receives Positive Final Appraisal Determination from National Institute for Health and Clinical Excellence (NICE) for Use in the National Health Service (NHS) in England and Wales". Reuters. April 23, 2009.
- ^ Ness, Stacey (13 March 2014). "New Specialty Drugs". Pharmacy Times. Retrieved 5 November 2015.
- ^ a b List A, Kurtin S, Roe DJ, et al. (February 2005). "Efficacy of lenalidomide in myelodysplastic syndromes". The New England Journal of Medicine 352 (6): 549–57. doi:10.1056/NEJMoa041668. PMID 15703420.
- ^ List AF (August 2005). "Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS)". Seminars in Oncology 32 (4 Suppl 5): S31–5. doi:10.1053/j.seminoncol.2005.06.020. PMID 16085015.
- ^ List A, Dewald G, Bennett J, et al. (October 2006). "Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion". The New England Journal of Medicine 355 (14): 1456–65. doi:10.1056/NEJMoa061292. PMID 17021321.
- ^ "Revlimid Approved In Europe For Use In Myelodysplastic Syndromes". The MDS Beacon. Retrieved 2013-06-17.
- ^ "Phase II Study of Lenalidomide for the Treatment of Relapsed or Refractory Hodgkin's Lymphoma". ClinicalTrials.gov. US National Institutes of Health. February 2009.
- ^ "276 current clinical trials world-wide, both recruiting and fully enrolled, as of 27 February 2009". ClinicalTrials.gov. US National Institutes of Health. February 2009.
- ^ "Celgene Discontinues Phase 3 Revlimid Study after 'Imbalance' of Deaths". Nasdaq. July 18, 2013.
- ^ "Revlimid Summary of Product Characteristics. Annex I" (PDF). European Medicines Agency. 2012. p. 6.
- ^ Rao KV (September 2007). "Lenalidomide in the treatment of multiple myeloma". American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists 64 (17): 1799–807. doi:10.2146/ajhp070029. PMID 17724360.
- ^ Bennett CL, Angelotta C, Yarnold PR, et al. (December 2006). "Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer". JAMA: the Journal of the American Medical Association 296 (21): 2558–60. doi:10.1001/jama.296.21.2558-c. PMID 17148721.
- ^ "Potential Signals of Serious Risks/New Safety Information Identified from the Adverse Event Reporting System (AERS) between January - March 2008". US Department of Health & Human Services. FDA. March 2008.
- ^ "FDA Drug Safety Communication: Ongoing safety review of Revlimid (lenalidomide) and possible increased risk of developing new malignancies". US Food and Drug Administration. FDA. April 2011.
- ^ Vallet S, Palumbo A, Raje N, Boccadoro M, Anderson KC (July 2008). "Thalidomide and lenalidomide: Mechanism-based potential drug combinations". Leukemia & Lymphoma 49 (7): 1238–45. doi:10.1080/10428190802005191. PMID 18452080.
- ^ Zhu, Y. X.; Braggio, E; Shi, C. X.; Bruins, L. A.; Schmidt, J. E.; Van Wier, S; Chang, X. B.; Bjorklund, C. C.; Fonseca, R; Bergsagel, P. L.; Orlowski, R. Z.; Stewart, A. K. (2011). "Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide". Blood 118 (18): 4771–9. doi:10.1182/blood-2011-05-356063. PMC 3208291. PMID 21860026.
- ^ Stewart, A. K. (2014). "Medicine. How thalidomide works against cancer". Science 343 (6168): 256–7. doi:10.1126/science.1249543. PMC 4084783. PMID 24436409.
- ^ Muller, G. W.; Chen, R.; Huang, S. Y.; Corral, L. G.; Wong, L. M.; Patterson, R. T.; Chen, Y.; Kaplan, G.; Stirling, D. I. (1999). "Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production". Bioorganic & Medicinal Chemistry Letters 9 (11): 1625. doi:10.1016/S0960-894X(99)00250-4.
- ^ a b "Revlimid faces NICE rejection for use in rare blood cancer Watchdog's draft guidance does not recommend Celgene's drug for NHS use in England and Wales". Pharma News. 11 July 2013. Retrieved 5 November 2015.
Further reading
- Chang DH, Liu N, Klimek V, et al. (July 2006). "Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications". Blood 108 (2): 618–21. doi:10.1182/blood-2005-10-4184. PMC 1895497. PMID 16569772.
- Anderson KC (October 2005). "Lenalidomide and thalidomide: mechanisms of action--similarities and differences". Seminars in Hematology 42 (4 Suppl 4): S3–8. doi:10.1053/j.seminhematol.2005.10.001. PMID 16344099.
External links
- Official website Includes list of adverse reactions
- Prescribing Information
- International Myeloma Foundation article on Revlimid
- multiplemyeloma.org Revlimid April 2007 Summary
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 移植候補患者における症候性多発性骨髄腫に対する初期化学療法 selection of initial chemotherapy for symptomatic multiple myeloma
- 2. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要 overview of neurologic complications of non platinum cancer chemotherapy
- 3. 癌免疫療法の原則 principles of cancer immunotherapy
- 4. 再発性または難治性多発性骨髄腫の治療 treatment of relapsed or refractory multiple myeloma
- 5. サリドマイドおよびその類似体による多発性骨髄腫治療後の血栓性合併症 thrombotic complications following treatment of multiple myeloma with thalidomide and its analogues
- Osteolytic lesions in patients with relapse of diffuse large B-cell lymphoma treated with lenalidomide.
- Schuelper N1, Flohr A, Trümper L, Wulf GG.
- Annals of hematology.Ann Hematol.2014 Nov;93(11):1929-30. doi: 10.1007/s00277-014-2071-7. Epub 2014 Apr 8.
- Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management.
- Vincent Rajkumar S.
- American journal of hematology.Am J Hematol.2014 Oct;89(10):999-1009. doi: 10.1002/ajh.23810.
- DISEASE OVERVIEW: Multiple myeloma accounts for approximately 10% of hematologic malignancies.DIAGNOSIS: The diagnosis requires 10% or more clonal plasma cells on bone marrow examination or a biopsy proven plasmacytoma plus evidence of associated end-organ damage. If end-organ damage is not present,
- Current regimens and novel agents for mantle cell lymphoma.
- Chen Y1, Wang M, Romaguera J.
- British journal of haematology.Br J Haematol.2014 Oct;167(1):3-18. doi: 10.1111/bjh.13000. Epub 2014 Jun 28.
- Mantle cell lymphoma is a heterogeneous subtype of non-Hodgkin lymphoma. Conventional treatment with immunochemotherapy followed by autologous stem cell transplantation or intensive immunochemotherapy alone has improved outcomes, but the disease remains incurable. Recent advances in basic and transl
- 多発性骨髄腫におけるレナリドミドによる二次がん : 最近のメタ解析結果をもとに
- 滝沢 牧子,半田 寛
- 血液内科 70(2), 268-272, 2015-02
- 二次発がん (特集 多発性骨髄腫の病態と最新治療 : 基礎と臨床の最新情報) -- (特論)
- 蒔田 真一,丸山 大
- 日本臨床 73(1), 162-166, 2015-01
- レナリドミドの免疫調整作用 (特集 多発性骨髄腫の病態と最新治療 : 基礎と臨床の最新情報) -- (特論)
- 半田 寛,斉藤 貴之,村上 博和
- 日本臨床 73(1), 156-161, 2015-01
- Lenalidomideとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Lenalidomideとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
- Before taking lenalidomide, tell your doctor and pharmacist if you are allergic to lenalidomide, any other medications, or any of the ingredients in lenalidomide capsules. Ask your pharmacist or check the Medication Guide ...
リンク元 | 「レナリドミド」 |
- 英
- lenalidomide
- 化
- レナリドミド水和物 lenalidomide hydrate
- 商
- レブラミド
- 関
- その他の腫瘍用薬
- サリドマイド誘導体;骨髄異形成症候群治療


text:
No such thing as a small change | |
PerlMonks |
Re: I post to Perlmonks anonymously...by greenFox (Vicar) |
on Dec 04, 2006 at 23:21 UTC ( #587763=note: print w/replies, xml ) | Need Help?? |
It was only once and I was being "obnoxious, obstreperous, and rude" (or at least one of the three). Unfortunately I can't remember the node so it can be happily downvoted but feel free to take it out on this one :-) --
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