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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Poplar Farm Bed and Breakfast
4 Self ratedPoplar Farm, West Stoughton Wedmore, Cheddar, BS28 4PP
Price From
View Rooms- Excellent
- 17 guest reviews
About the hotel
Situated just 2 miles from the fashionable village of Wedmore, Poplar Farm is a working farm where we rear beef animals, sheep and poultry. The Farmhouse is a 17th century somerset longhouse offering good size family accommodation, evening meals are available by prior arrangment. We are in a ideal area for touring the holiday attractions of Somerset; Cheddar Gorge, Glastonbury Abbey, Wells Cathedral, Wookey Hole Caves, the new Pier at Weston Super Mare, walking, fishing or bird watching on the Somerset Levels, local golf within 1 mile.
Just 6miles from Junction 22 M5 and within easy reach of Bristol, Bath, Taunton Longleat Safari Park all within 1 hour. Bristol air port is only 15 miles away
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Facilities Show/hide
- Main
- Hotel Non-Smoking Throughout, Cots available, Tea/Coffee making facilities in each room, Hairdryer in each room, Ground floor bedrooms
- Parking
- Car parking available onsite
- Business
- Wi-Fi Available, Wi-Fi Available In Public Areas
- In Room Entertainment
Useful Info Show/hide
- Between 17:00 and 19:00
- By 10:30 hours
- Up to 14 years old
- The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
100% would recommend it to a friend
Customer service
Food quality
Room quality
Poplar Farm Bed and Breakfast
We chose this because the children wanted to see the animals: black sheep, ducks and cows.
The host is very friendly and let the children fe...
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Great little find
Lovely B&B close to the village of Wedmore (very pretty - great pub, The Swan).
Warm welcome, including by Ruby the dog. Tea and cake on arr...
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Another week, another 2.8 billion tweets posted on Twitter.
With the internet craze surrounding the Netflix debut of Arrested Development, the not-so-positive reviews for Will Smith (and his accent) in After Earth, the release of the wild trailer for David Lee Roth's Japanese short film and the polarizing reactions to Ryan Gosling's latest, Only God Forgives, plenty of funny and insightful comments were shortened to 140 characters or less.
We've taken the time to bring you some of our favorite tweets surrounding pop culture events of the last week, but know that we couldn't do it without including few Amanda Bynes-related comments.
Sign up for the Paste newsletter Get our daily summary of the day's top articles and new items. Sign Up Thank you! Your email address has been added to our list. You will begin receiving our newsletter within 48 hours.

subset: commoncrawl


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Product description
The fat, funky tones of the SansAmp Bass Driver series are legendary. With an all-analog signal path, two inputs, six presets, a programmable effect loop, and parallel/tuner out, the stage-optimized Deluxe is all that with cheese and pickles.
- Take a SansAmp Bass Driver into the studio and plug directly Into the board for premium tones without miking.
- Gig with a SansAmp Bass Driver running it directly through the house PA without using a separate amp.
- Set-up with a SansAmp Bass Driver, power amp and speaker cabinet, and simultaneously run directly through the house PA for planet-dominating sound.
- Operable with a 9V alkaline battery, optional Tech 21 DC2 power supply, and via phantom power.
- Measures 9.75"l x 5.25"w x 2.0"h
Additional information
Name | Tech 21 USA SansAmp Bass Driver D.I. Deluxe |
Brand | Tech 21 |
Model | SansAmp |
Product group(s) | - |
Category | Programmable bass preamp pedal and DI box |
Specials | No |
Order processing time
We ship worldwide on daily basis, with DHL, DPD, and UPS. All in-stock items are usually shipped within 24h upon receipt of payment, mostly on the same working day. Of course, all orders are checked by our qualified personnel and professionally packaged for shipping. Express delivery options are available upon request.
A transport insurance cover up to the full value of the purchased item(s) is already included, at no extra charge.
COD (cash on delivery)
5.00 € COD fee for shipping within Germany. Unfortunately, we currently don't ship COD to addresses outside of Germany.
Personal purchase at our store
Of course, you are absolutely welcome to personally visit our shop premises in Munich to check, test, compare, purchase and take home your items right away, without any waiting, stress or pressure, and with a proper professional advice from our product experts. Please feel free to contact us for your individual time appointment, or simply visit us during our business hours!
Shipping outside the EU
Shipping costs to most EU destinations, Switzerland and Norway are included in the overview on the left. Selling and shipping to any countries not mentioned in this overview is subject to prior inquiry and receipt of our shipping quotation. Please also note that not all orders from all countries can be automatically processed through our website at this time; such orders must be handled on individual basis. If you are outside the EU, please make sure to contact us first, for necessary details on the ordering procedure, shipping and payment. Please make sure to provide us your full address for a correct calculation of the shipping expenses.


text: Papa John Allegedly Used To Get Trashed With "Chicken Heads"Tom Ley4/12/13 4:59pmFiled to: garlic saucedgetting faded with papa johnpapa john all fucked up at a basketball gamepapa johndrinkingpizzanews101EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Earlier this week, we asked our readers to share their firsthand accounts of Papa John getting shitfaced, because it has recently become clear that the Papa really likes to get shitfaced. Here's a story from reader Sam: I used to frequent a bar in Louisville, KY called "Mr. G's" about 4-5 years ago and I would always see Papa and his COO at the time (forgot his name, but he was an English or Scottish gentleman) canoodling with "classy" bleach blonde, spray tanned chicken heads who were, no doubt, NOT the spouses of these two gentlemen - both of whom are married. They would always sit in a booth, get trashed out of their loud and obnoxious heads, and then leave together. I remember the bartenders always told me he was a shitty customer and an even shittier tipper. His admiration for strange snatch other than his wife's is pretty well known around these parts. Classy guy, that Papa John... Ask him about Mr. G's and I guarantee he turns as bright red as his processed and tasteless pizza sauce.We called Mr. G's and spoke with a very nice woman. She remembered seeing Papa at the bar. She said he'd come in "a couple of times a month" and drink, sometimes with friends. Whether they were chicken heads, we were unable to ascertain. Advertisement Advertisement Got a story about drinking with the Papa? Email us: firstname.lastname@example.com repliesLeave a reply


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One Response to Telepsychology guidelines anticipated
Thank you for this timely article. The guidelines are indeed eagerly anticipated.
For those readers who want to see other "Telemental Health Standards, Guidelines, Best Practices & Other Statements* to compare and contrast to the APA's, over a dozen are identified and linked here: http://telehealth.org/ethical-statements
You may also be interested in seeing the ATA mental health SIG's recently released guidelines for telemental health. They are open for comment until April 21: http://www.americantelemed.org/practice/standards/standards-open-for-comment/practice-guidelines-for-video-based-online-mental-health-services?goback=.gsm_4288557_1_*2_*2_*2_lna_PENDING_*2
I also commend the author above for hinting that it is time for us to start considering alternatives to direct care for intervening with people who can benefit from our services. We can help many who would never come to a therapy office by developing self-help materials that are evidence-based and marketed online.
There are many successful strategies to develop and market self-help materials online (ebooks, podcasts, continuing programs, audio books, Kindle books, webinars, apps, etc.), but most mental health professionals haven't been schooled in these skills yet.
It is not anticipated that the APA telepsychology guidelines will cover such issues, but other highly respected professional associations have, For instance,they were addressed by the Australian Psychological Society. (2004) in their document entitled, "Guidelines for Providing Psychological Services and Products on the Internet.."
http://psychology.org.au/Assets/Files/EG-Internet%5B1%5D.pdfAgain, see more ethical guidance for telepsychology here: http://www.telehealth.org
Marlene M. Maheu, Ph.D.
TeleMental Health Institute, Inc.


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Cashier Ripped Up RR ?!
I know there is a post regarding the Colgate RRs, but am posting this question in the Walgreens general area in the hopes I can understand Walgreens Policy correctly for future register rewards deals . . .
Last night, after I read the RRs were rolling, I went with my 2 Colgate RRs to separately purchase 2 more Colgates (I had already bought 2 with coupons earlier). The cashier said that if I used a Colgate RR to buy a Colgate toothpaste, a new RR would not print out. I said 'that's OK', because of what I had read here and assumed she just did not know that this deal was rolling. We were talking about this as the transaction was completed and I said 'I think this Colgate RR will still print out'. As it was actually printing, she said 'If it does, we will have to destroy it. It is not supposed to print for something you just used one on.' She then proceeded to tear it up! She said that it was called 'looping' and that they were not supposed to give the RR out . . . Is this correct and the policy is just not followed elsewhere, or was this cashier making her own policy?! Thanks in advance for any advice. |
The Following 9 Users Say Thank You to cmomaha For This Useful Post: | ||
The Following 6 Users Say Thank You to sdreyer For This Useful Post: | ||
I remember this happened to several Wuckies during the Dove soap deal about 6 months or so ago. Cashiers were told to destroy the RR's.
The Following 6 Users Say Thank You to johnsonld24 For This Useful Post: | ||
Wow, I've heard of stores referring to "looping" but to tear up a RR that you just earned would tick me off! Now, if she had told you before your purchase that they were only allowing one RR for say Colgate and you went ahead and purchased it anyway, knowing because of what you heard that the RR would print, I would kind of understand where they were coming from. They are trying to eliminate people rolling the same RR indefinitely but still....
Jona Click on the link below to start earning easy $$$ searching the web!!! |
The Following 8 Users Say Thank You to jb16510 For This Useful Post: | ||
Yes, she was saying it as the transaction was happening. Then, I thought to myself that I had just bought the toothpaste for free so it was OK. I was so flustered, though, that it didn't occur to me until after I left that I actually lost out on the $3 RR for the first purchase. So, even if my out of pocket for the second Colgate was $.20 tax, I had paid $2+ for the first colgate to receive the $3 RR . . .
I do want to mention that she was very nice throughout the process and didn't imply that I was buying too many, etc. (only 2 anyway). |
The Following 6 Users Say Thank You to cmomaha For This Useful Post: | ||
So, were all of the cashiers across the country supposed to tear up the RRs for the Colgate this week? Or did I just run into a cashier who independantly decided that was the proper procedure for this situation, too?
The Following 5 Users Say Thank You to cmomaha For This Useful Post: | ||
I bet it was her call, because others said they got the RR when it printed.
The Following 6 Users Say Thank You to meemaw1 For This Useful Post: | ||
Unfortunately it is up to the store when it comes to identical rolling..... however, I have never had a cashier not give me my reward much less TEAR IT UP!!! How dare her!! Grrrrr... I feel ya! For sure!!
I haven't done the toothpaste this week, minus getting ONE Sunday just to roll a $3 RR I had, so I can't comment on that. But, we have a Walgreens here that will only allow 1 RR per item, per person, per day. I did not know this when I went in a few months ago (I believe the Smart Waters were the deal). I did 3 transactions, 1st one with the water, 2nd one with something else, and the 3rd one was the water again. When I paid for the 3rd transaction, I was waiting on my change and my RR (which did print out). The manager rang me up, btw, and she said she could not give me the RR and took it and tore it up and threw it away. So, it does happen!
The Following 5 Users Say Thank You to WendyBHall For This Useful Post: | ||
Definitely either a rogue store or rogue cashier since the majority of people have been rolling this RR deal since Sunday. Sorry you had issues at your store.
Jona Click on the link below to start earning easy $$$ searching the web!!! |
The Following 4 Users Say Thank You to jb16510 For This Useful Post: | ||
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Apple Trichy Service Center-address, contact number, email ID, phone number and other details like rating and review is available here.
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Message view | « Date » · « Thread » |
Top | « Date » · « Thread » |
From | David Crossley <cross...@apache.org> |
Subject | mail is moderated |
Date | Fri, 24 Jun 2005 06:14:36 GMT |
Ferdinand Soethe wrote: > Ferdinand Soethe wrote: > > >> * Send the announcement, as described a few messages ago in this thread. > > > Beefed up the announcement with that neat new generator (see > > http://marc.theaimsgroup.com/?l=forrest-dev&m=111695995215534&w=2) > > and sent it. Yeah! > > Sorry about sending this more than once. I had a few problems sending > the announcement as email@example.com because I never usually post > from this address. And when they were fixed it seems that some of my > rejects got processed after all. Ah, you a misunderstanding how it works. You are subscribed to the list as one address. When you send from another address, then the message sits is a queue waiting for a human moderator to approve it. I had to do that for this message. There are three moderators for Forrest spread around the world. My technique is: if they are a bone-fide poster, then i add them to the "allow" list. So next time their posting goes automatically. Just did that for your apache.org address. I notice that we have not seen the announcement(s :-) to xml.apache.org Perhaps the moderators of that list, whoever they are, have not dealt with it yet. -David | |
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Ford Model
Focus Esate 1.8 TDCI
UK/Ireland Location
Please tell us all what's gone wrong with the head? This engine is not known for this issue.
Dear All Yes you are indeed correct about the history of the Lynx engine, but it's only a few mods that were done, nothing really was that different in the overall design layout of the block and camshaft. I seem to remember that the old 1.8 lynx engine on my old Escort had bucket and shim adjustment for the valves. I say this as I changed the timing belt and I distinctly remember the cam shaft had the locking bar slot in the cam end, same as the Endura. So why is this mechanic talking about rocker arms on his TDCI Diesel to Kcr4cer?
iantt liked a post in a topic: 1.8 Tdci Ticking Noise?
As you have mentioned rocker arms in you post I wonder if we are all talking about the same engine, as my 1.8 TDCI 4 cylinder 8 valve Endura Diesel did not have rocker arms, as the cams worked directly onto the valve buckets.
If it's in good nick and you like the car go for it, as these old Focus Diesels can go on forever. My Diesel 1.8 focus estate got to 173,000 before I sold it. It that time apart from the scheduled service items it had had a new DMF plus rear suspension bushes and exhaust. I don't think the Endura 1.8 Diesels are known for camshaft problems, but you can never tell. The bucket shims are though rather expensive if you need to reshim the whole 8 valves. I don't suppose it's just that you are hearing a mechanically internally noisy injector ticking, I don't mean diesel knock?
dogdays1 started following 1.8 Tdci Ticking Noise?
The timing belt should be changed at 110,000 miles but because of the cars age it needs changing ASAP, because if it loses its teeth it will destroy your engine completely and the car will be scrap. Do not delay and change the water pump as well, as its part of the belt run.
dogdays1 started following Took My 2.0tdci C-max For A Service And It No Longer Starts
Focus and Cmax diesels to have a problem with the filter housings and they usually break after having the filter changed on a service. You are not alone on this issue.
Yes the coolant reservoirs do rattle a bit, but that's not what I am talking about on my car, Mine is noisy valve gear and pistons clanging when cold, though I am told that sometimes cheap supermarket fuel can cause injector clatter on this engine. Honestly,I have heard Diesels that are quieter than my engine when it's cold.
Hi All Just to update you. I first had a listen to friends engine and it is as noisy as mine. I then took the car into the Ford agents with a covering letter, asking them to listen to the noise and record the findings on the car's service record, as its only done 1800 miles. They said that they all sound like this when cold. I think you will find that it's because the cylinder head is allowed to warm up before the rest of the engine,so as to help fuel efficiency and emissions. This means we get valve gear clatter and piston slap until the whole engine reaches full operating temperature. Have it officially checked by all means, but I think you will find they are all the same when running from cold and sound like a barrel of bricks.
I have the same issue with my 1650 mile ecoboost 125ps C Max. There is a light knocking from the passenger side that increases with revs when cold. It goes away when the engine is hot . It could be the turbo bearings or perhaps piston slap. Has anyone come across this problem?
More information please, does not start and cut out in ___gear? Have you had the fuel filter change? Is the engine turning over without the usual resistance to the starter motor?
Harrowman liked a post in a topic: Ford Focus Or C-Max 1.8 Tdci Engine Wiring Loom
It seems rather dramatic to seek a new loom when all you say you have damaged is the plug. Surely its possible to find a breakers with a smashed car, cut the section of loom that goes to the ecu, then splice the new plug and cable onto your old loom with connectors.Its not as if this is a new car. I will go look at my 1.8tdci Focus in the morning. Incidentally, do you find your EGR gives a shushing noise at certain throttle openings? Mine always has.
Have you filled up with supermarket fuel? If so try Esso or Shell before going back to Ford,
The concentric cylinder is the modern version of the hydraulic cylinder and release bearing. The cylinder used to live outside on the gearbox bell housing and work a pivoted lever that went to the release bearing inside the gearbox housing. Nowadays its built into and inside the unit and is impossible to get to without the complete dismantling of the power unit/clutch assembly, which you will be having done to replace the DMF. That's why it needs to be changed, even if there is nothing wrong with it.
This £600+Vat is very reasonable. I suppose they are using good quality parts and changing all the bits including the concentric release bearing assembly? Before taking the car in best check this. The car will certainly be better when its done. It will be smoother and the clutch will be lighter.


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We're so excited to share with you the latest finds - check out what's new and browse around for fun gifts for the gorgeous fall season coming up.
Follow these links to shop items in our store (under $100).
This is our most popular item, ever: the Reiko Kaneko Gold Lip Tease Mug.
Or, browse collections from our latest designers: Vivo Studios, Alexia, Waylande Gregory, and RabLabs.
It's Spring again! Welcoming a new season of growth, change, and renewal.
From all of us to all of you, wishing you the very best holiday season.
A set of barrettes from a special someone, a daughter's first pair of earrings, a ring inherited from a grandmother, a lovingly-designed pin from a kindergartener, and other treasures - where do we keep such beautiful treasures?
A two-year-old's lock of hair, a handwritten note for Mother's Day, a gorgeous bracelet gifted from a friend.
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All of these and more fit perfectly into our lacquer boxes.
From the minute I entered their website, I knew I would love these scarves right away. Whimsical, colorful and a keen attention to detail are just a few of the hallmarks of London based Swash Scarves.


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Wednesday, June 22, 2011
LCY Home Tour: The Bedroom
21 comments:
love the tea cups! so cute. xoxo jillian:: cornflake dreams
ReplyDelete- AnonymousJune 22, 2011 at 8:09 AM
I agree! Tea cup idea is charming. Do you have a closet?
ReplyDelete I'm not gonna lie, my heart skipped a beat for a second when I saw your little tea cup collection because I have a few at my parent's house because they looked super dowdy in my china cabinet so I boxed them up. Your cute idea is just what I needed and I'm picking them up today. I'm super into fun ways to DISPLAY my jewelry. I hate keeping it in a box or something. Love it and I'm so into homemade ways to make my bedroom my own. Poor husband, flowers, pink, jewelry and now tea cups. He's gonna die.
ReplyDeleteI'm in the process of doing a whole decoration in our new place as well. I love your ideas! thanks for the lovely pictures!
730design.blogspot.com- CynthiaAugust 4, 2011 at 2:32 AM
Please oh please tell us the incredible light gray paint color you used throughout! Incredibly light, airy, artistic home!


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Beer-braised Beans Recipe
My husband's favorite beans. Sunset Books, Low-fat Vegetarian. Prep:25m
beans, beer, onions, tomato, bread, molasses, mustard powder, soy sauce, +brown sugar, +sour cream, +olive oil, +water
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Diabetic Baked Beans
Originally from a diabetic cookbook, it's my preferred way to enjoy baked beans, even though I'm not diabetic (DH is), because it's so easy and the taste...
beans, mustard powder, molasses, onions, soy sauce, +olive oil, +garlic
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Marinated Chicken Wings
garlic powder, soy sauce, onions, molasses, mustard powder, +salad greens, +chicken
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Moist Turkey Burgers
"'Although I've tried a number of turkey burgers, I always thought they were too dry,' says Shirlea Ann Roman of Jamestown, New York. 'Cooking the onion...
garlic powder, mustard powder, onions, soy sauce, tomato, +vegetable oil, +hamburger bun, +turkey, +lettuce, +black pepper, +poultry seasoning, +salt, +bread crumbs, +worcestershire sauce
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Comfy Baked Beans
These are the best baked beans I've ever eaten! It is one of those meals that make you look forward to winter. I use crushed tomatoes to make them, but...
tomato, mustard powder, molasses, onions, beans, +brown sugar, +ketchup, +black pepper, +salt, +bacon
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beans, onions, molasses, mustard powder, beer, +ketchup, +salt, +vinegar, +curry powder, +worcestershire sauce, +pork chops
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Steve's Finger Lickin' B-B-Q Ribs
molasses, onions, beer, mustard powder, garlic powder, +pork ribs, +lemon juice, +ketchup, +hot sauce, +honey, +cayenne, +chili powder
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Steak Bake Casserole
tomato, onions, beans, molasses, soy sauce, +mushroom, +steak, +green pepper, +shortening, +flour, +black pepper, +salt, +sesame seed
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56K PCI Voice Modem SF-1156IV R9A Driver Update UtilitySupported OS: Windows 10, Windows 8.1, Windows 7, Windows Vista, Windows XPFile Version: Version 3.6.7 File Size: 2.2 MB File Name: DriverNavigator_Setup.exeDownload >> |
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NC-17 Trekking Handlebar Renowned for their MTB bars, NC-17 now bring you a trekking handlebar. You name it, they have it The NC-17 Trekking handlebar has the most elaborate geometry of the entire NC-17 range. The sole focus was on rider comfort. The adjustable stem allows for almost any seating position and the 34 incline to the driver reduces wrist fatigue and consequent loss of grip strength. Made from aricraft grade aluminium, its almost indestructible. Features: Material: trekking aircraft aluminum T6. Position Markers. Identification number. Sweep: 16 . Back Sweep: 32 . Height: 4.5 . Width: 618mm. Weight: 343 grams. Bar clamp: 31 8mm. Buy NC-17 Components from Chain Reaction Cycles, the Worlds Largest Online Bike Store.
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text:
Franklin Roosevelt's Safe Files, dating from 1933-1945, consist of formerly National Security Classified materials, mainly from the World War II period. The Safe Files include correspondence, reports, and memoranda concerning: the Manhattan Project, the Atlantic Charter and the United Nations, the O.S.S., the War, Navy, Treasury and State Departments, Germany, Japan, Italy, Russia, China, Great Britain and France, General George Marshall, Generalissimo Chiang Kai-shek, Ambassador Averell Harriman, Admiral Ernest King and Harry Hopkins, as well as the American-British Joint Chiefs of Staff, the Pacific War Council, and "Plan Dog".
Box 1 Box 2 Box 3 Box 4 Box 5 Box 6


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Borden sophomore Shelby Kirchgessner hit four three-point baskets in the first quarter and added another late during her team's 68-37 win over visiting West Washington Thursday. Kirchgessner's early 3s were only worth 12 points on the scoreboard, but were even more valuable than that as they forced West Washington to soften the zone defense. With the Lady Senators closing out on Kirchgessner, it left room in the paint for Erin Mikel and Allison Rademacher to move around.
p { margin-bottom: 0.08in; }
By George Browning
Managing Editor
Green Banner Publications


text:
Wed Jun 27, 2012, 08:06 PM
cal04 (41,409 posts)
Obama Bain Attacks On Mitt Romney Leave Swooning Democrats In Love Again
A slew of new battleground state polls released this week lend credence to the Obama campaign's argument - often offered to reporters in private -- that attacks on Mitt Romney's tenure at Bain Capital are a winning strategy. (snip) For a presidential campaign that endured days of second-guessing over its decision to attack Bain Capital at the general election's onset, the numbers are being treated as nothing short of vindication. And for those Democrats who watched as their colleagues in the Northeast Corridor openly fretted about attacks on wealth, it was a chance to wonder aloud about the party's backbone. "We are pussies, good God you can quote me on that," said David "Mudcat" Saunders, the longtime Democratic consultant. "There is nothing wrong with having a fine car and a fine house and living the American dream. But the greed! Bain Capital is about greed. ... It stinks morally." Added another top Democrat, who lobbied the campaign privately to continue the Bain attacks: "It was surprising and disappointing that these folks who are politically on the tour -- they aren't novices -- would not understand that what they said had the potential to undercut the president's strongest message. It was like, 'Don't you realize you are in the fight of our life here?'"
5 replies, 1170 views
Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
5 replies | Author | Time | Post |
Obama Bain Attacks On Mitt Romney Leave Swooning Democrats In Love Again (Original post) |
cal04 | Jun 2012 | OP |
BumRushDaShow | Jun 2012 | #1 | |
bluestateguy | Jun 2012 | #2 | |
Drunken Irishman | Jun 2012 | #3 | |
Zen Democrat | Jun 2012 | #4 | |
ajain31 | Aug 2012 | #5 |
Response to cal04 (Original post)
Wed Jun 27, 2012, 08:10 PM
bluestateguy (44,173 posts)
2. You can always count on Mudcat Saunders for the money quote
And he's man enough to go on the record. He's not likely to be one of these worry wart anonymous "Democratic consultants" who like to blab to the media with all their doom and gloom.
Response to cal04 (Original post)
Wed Jun 27, 2012, 08:15 PM
Drunken Irishman (28,436 posts)
3. Good thing he didn't listen to Corey Booker, eh?
Response to Drunken Irishman (Reply #3)
Wed Jun 27, 2012, 09:45 PM
Zen Democrat (5,719 posts)
4. or Ed Rendell ...
or the pitiful Harold Ford, Jr.
Response to cal04 (Original post)
Wed Aug 1, 2012, 10:13 AM
ajain31 (63 posts)
5. Ten FACTS about BAIN Capital:
Here are the top 10 comments about Bain from Romneys Republican rivals:
1. The idea that youve got private equity companies that come in and take companies apart so they can make profits and have people lose their jobs, thats not what the Republican Partys about. Rick Perry 2. The Bain model is to go in at a very low price, borrow an immense amount of money, pay Bain an immense amount of money and leave. Ill let you decide if thats really good capitalism. I think thats exploitation. Newt Gingrich 3. Instead of trying to work with them to try to find a way to keep the jobs and to get them back on their feet, its all about how much money can we make, how quick can we make it, and then get out of town and find the next carcass to feed upon Rick Perry 4. We find it pretty hard to justify rich people figuring out clever legal ways to loot a company, leaving behind 1,700 families without a job. Newt Gingrich 5. Now, I have no doubt Mitt Romney was worried about pink slips whether he was going to have enough of them to hand out because his company, Bain Capital, of all the jobs that they killed Rick Perry 6) He claims he created 100,000 jobs. The Washington Post, two days ago, reported in their fact check column that he gets three Pinocchios. Now, a Pinocchio is what you get from The Post if youre not telling the truth. Newt Gingrich 7. There is something inherently wrong when getting rich off failure and sticking it to someone else is how you do your business, and I happen to think thats indefensible Rick Perry 8. If Governor Romney would like to give back all the money hes earned from bankrupting companies and laying off employees over his years, then I would be glad to then listen to him Newt Gingrich 9. If youre a victim of Bain Capitals downsizing, its the ultimate insult for Mitt Romney to come to South Carolina and tell you he feels your pain, because he caused it. Rick Perry 10. Theyre vultures that sitting out there on the tree limb waiting for the company to get sick and then they swoop in, they eat the carcass. They leave with that and they leave the skeleton Rick Perry Just last night, Newt Gingrich defended his attacks, saying I think there are things you can legitimately look at in Bain Capital. I think there are things you can legitimately look at in anybodys record, including Mitt Romneys record. |


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Image (c) Adam Britton, crocodilian.com
Order: Crocodylia
Family: Crocodylidae
Subfamily: Crocodylinae
Genus & Species: Crocodylus johnstoni (Crocodylus johnsoni)
The Australian freshwater crocodile is a small cousin of the Australian saltwater crocodile. Sexual dimorphism is present in this species, with males being larger than females. The males reach lengths of 8-10 ft max (2.4-3 m) and weigh 40 lbs (90 kg). The females reach lengths of 7.8 ft (2.3 m) and weigh 20 lbs (45 kg). Although there are no subspecies, smaller, darker- coloured populations can be found farther upstream, perhaps due to food availability. They reach lengths of 5 ft (1.5 m). Australian freshwater crocodiles grow very slowly, and may not reach full lengths for 20 years.
Australian freshwater crocodiles have unusually narrow, tapering snouts, being rivaled by that of the gavial. The mouth is lined with 68-72 sharp teeth. The fourth tooth on either side of the bottom jaw is larger than the others, and can be seen when the mouth is closed, fitting into a notch on the upper jaw. The eyes have a special clear eyelid called a nictitating membrane, which protects the eyes while underwater.
Australian freshwater crocodiles have strong legs with clawed, webbed feet. The tail is very powerful. The skin is light brown in colour, with dark bands on the body and tail and sometimes on the snout. The scales are large, with wide plates on the back and ventral osteoderms (bony plates) on the belly. The flanks and outside of the legs are covered in pebbly scales.
Australian freshwater crocodiles are one of the few species that can gallop on land, reaching speeds of 18 km/h. They have a life span of 50 years.
Australian freshwater crocodiles are found only in the provinces of Queensland, Northern Territory, and Western Australia in Australia. They are found predominately in freshwater lakes, billabongs, swamps, rivers, creeks, and wetlands, although not by choice. The Australian saltwater crocodile keeps them out of more saline (salty) areas by outcompeting them. However, when this species was near extinction Australian freshwater crocodiles could be found in saltwater. Today, they are found mainly in freshwater and brackish areas. They are not fussy over water, and will live in muddy, clear, fast, still, deep, or shallow water. After the rainy season they move to more permanent areas of water that will not dry up in the dry season, and will rarely eat and hardly grow until they return at the start of the next rainy season.
Australian freshwater crocodile juveniles feed on insects, crustaceans, and small fish. Larger and older crocodiles feed on the same things, as well as larger prey such as amphibians, reptiles, bats, large fish, and land mammals that come close to the water. They can also be cannibalistic and will eat juveniles. They do not hunt on land but will wait at the water's edge for prey, typically fish, to get close, and then will attack with a lightning-fast snap of the head. They also hunt underwater. They swallow stones to aide in digestion, and drink only freshwater, not saltwater.
Although they have osteoderms, Australian freshwater crocodiles where still hunted for their hide for 14 years when Australian saltwater crocodiles were no longer abundant. Australian freshwater crocodiles were then considered rare, and hunting was stopped in the 1960's and 1970's. It wasn't until the 1980's that their populations became stable. Today they are hunted by aboriginals for food.
Juveniles are killed by the adults when food is scarce. They are also eaten by black kites, whistling kites, turtles, and large fish. Gould's monitor lizards, sand goannas, and feral pigs also keep the numbers down by destroying 80% of Australian freshwater crocodile nests. Habitat loss to farmland is also a major threat. They are considered to be low risk.
Sexual maturity for females is reached at 11-14 years, for the males 16-17 years. The breeding season is from September to October. Hole nests are dug in the river bank by the females, and are generally dug 50 ft (15 m) away from the water's edge and are 5 in (12 cm) deep. Anywhere from 4-21 eggs are laid, and they hatch after an incubation period of 6-10 weeks. The temperature of the nest determines the sex of the juveniles: 31-31 °C — males, above and below that mostly females. When the eggs are ready to hatch, a female (not necessarily the parent) digs out the nest and crushes the eggs to release the juveniles, even though they have an egg tooth and could get out themselves. The juveniles sometimes get injured by her sharp teeth as she carries them to the water's edge. Less than 1% of the eggs laid will become mature Australian freshwater crocodiles.
There are no subspecies. There are 23 species of crocodilians found worldwide.
1. www.flmnh.ufl.edu/natsci/herpetology/brittoncrocs/csp_cjohn.htm
2. www.flmnh.ufl.edu/natsci/herpetology/act-plan/cjohn.htm
3. www.kingsnake.com/oz/crocs/johnstoni.htm
4. mag-nify.educ.monash.edu.au/acps99/Freshwcrocodile.htm
5. www.milamba.com/australia/inhabit/reptiles/rep10.htm
6. link.springer.de/link/service/journals/00360/bibs/9169003/91690215.htm
7. www.bitme.com.au/aviary/crocodiles.html


text:
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April 25, 2012 Arkansas Outdoors Newsletter
Lower White Oak Lake renovation forces closure
CHIDESTER - Lower White Oak Lake in Ouachita and Nevada counties will be closed to public access beginning Tuesday, May 1. The Arkansas Game and Fish Commission is in the midst of a two-year project to renovate the lake after the lake's water control structure failed. It is necessary to close the lake to insure the public's safety and provide AGFC staff and contractors room to work on repairs to the structure.
Hot Springs fishing challenge starts May 1
HOT SPRINGS – Crank up your fish-finders, try Grandpa's favorite vintage lure, dig a bucket of worms from that leaf pile in the corner of the back yard, buy yourself some crickets or minnows. Then set your sights on No. 22. That's the tag number that will bring you a cool 10 grand if you land "Big Al" in the first-ever $50,000 Hot Springs Fishing Challenge, which begins May 1 on Lake Hamilton and Lake Catherine at Hot Springs National Park, Arkansas.
Mom's Lake dedication scheduled for May 3
LITTLE ROCK – Mom's Lake, the Arkansas Game and Fish Commission's newest addition to the Family and Community Fishing Program, will be dedicated on May 3 at 1 p.m. Mom's Lake is near Corning in Clay County.
Great Cotter Trout Festival begins May 4
COTTER – The small, northcentral Arkansas town of Cotter will be celebrating the title of "Trout Capital, USA" beginning May 4 during the Great Cotter Trout Festival. The two-day festival will give trout fishing enthusiasts a first-hand look at the world-class trout fishing on the White River.
Comment period for proposed AGFC fishing regulations opens May 1
LITTLE ROCK – The Arkansas Game and Fish Commission will be compiling feedback from anglers on the 2013 fishing regulations beginning May 1. This year, anglers will be able to provide input on the AGFC's annual fishing regulations process by going to the agency's website, writing a letter or by sending an email.
More Information
Read the full newsletter


text:
On the performance...
"I'm happy with the performance of the team
and I'm happy with the mental strength we've shown because
we were one-nil down with a set piece and we've come back to
win. We should have won more comfortably, of course. Overall the
performance was spot on, we didn't panic when we were one-nil
down and kept going. I think we played well. We really deserved to
win this game."
On sealing a Champions League spot...
"Not completely but it's a big step. With a
game in hand, of course we want to focus now on our next game. To
lose the game today would have put us in a bad situation."
On the mental test...
"I felt it was an interesting case to see how
strong we are mentally and how much we believe in the football that
we play. I got a quick response because we created chance after
chance, we outplayed - in fairness - Bolton with the pace of our
On killing the game off...
"Even at 2-1, you see how we conceded our first
goal, there is a free kick and one minute to go and you have not
taken our chances, you always fear that it can go for them again
and they can get a 2-2. I feel everybody wanted to score and in the
end nobody scored - it's always like that when you want it too
much, it doesn't happen. I have to watch it very closely on the
tape because it looks very strange to me."
On a run of poor results...
"Last week we were in a bad situation, losing
here and going to Newcastle, and having to play Bolton of course.
But we responded well mentally, with a team you live in a tunnel
and sometimes you have to experience - to go down a little bit, to
flirt with the hell, to see how much you can deal with that to come
up and be stronger. I feel we had a disappointing three or four
weeks, and to experience how we would respond to that situation
I'm very proud of how the team responded and I respect a lot
what they did, the way they behaved in the last few weeks, even if
they were the most painful few weeks of the season. Unfortunately
you go very quickly to hell and very slowly to heaven!"
On Arsenal's pace and passing...
"I felt our pace was higher, in our passing and
we were very mobile, that gave them a big problem. And the fact
that our link play was very good in the middle of the park and our
midfielders interchanged their positioning very well - in the first
half especially - they never knew who to take. Before they got
close to us we moved it again and the speed of our passing was a
big problem for them."
14/1 - Arsenal v Man City: Cesc Fabregas to score the first goal - FREE £10 BET
Copyright 2017 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source


text:
If you like oldschool runescape, then go and play it. They have released 2007 runescape servers. Now off you go!
The reason PvP in MMOs is fun is because there's not so much of a risk. You die and you can proceed like nothing happened. Gear is also way more special in WoW than it is in RuneScape.


text:
Written | 2012-09 | Yi-Hong Zhou |
The University of California, Irvine, USA |
Identity |
Alias_names | DHRD |
fibrillin-like | |
EGF-containing fibulin-like extracellular matrix protein 1 | |
Alias_symbol (synonym) | S1-5 |
Other alias | DRAD |
HGNC (Hugo) | EFEMP1 |
LocusID (NCBI) | 2202 |
Atlas_Id | 49818 |
Location | 2p16.1 [Link to chromosome band 2p16] |
Location_base_pair | Starts at 56093097 and ends at 56151298 bp from pter ( according to hg19-Feb_2009) [Mapping EFEMP1.png] |
Fusion genes (updated 2016) | ANKH (5p15.2) / EFEMP1 (2p16.1) | EFEMP1 (2p16.1) / EFEMP1 (2p16.1) | EFEMP1 (2p16.1) / HSPA1A (6p21.33) |
Figure 1. A. Three transcripts were reported in Genebank for variant 1 (NM_004105), variant 2 (NM_001039348), and variant 3 (NM_001039349). NM_004105 has been permanently suppressed because currently there is insufficient support for the transcript. Variant 3 originates from alternative splicing of exon 2 in variant 2. B. Primers used to detect methylation of EFEMP1 promoter in cancer. C. EFEMP1 proximal promoter and sequence upstream of translation start site. Three SP1-binding sites and an estrogen response element (ERE) binding site are underscored, CG residues are marked in green, exons in uppercase, and MSP/BGS primer locations in boldface with sequences shown in B. | |
Transcription | The EFEMP1 coding region extends over a genomic interval of 56485 bp and comprises 10 exons. EFEMP1 proximal promoter lacks TATA or CAAT regulatory boxes and is rich with CG residues. EFEMP1 expression is repressed by promoter methylation in several cancer types and cancer cell lines. Primers used to detect EFEMP1 promoter methylation are show in figures 1B and 1C. |
Protein |
Note | The two transcription variants encode the same EFEMP1 protein of 493-amino acids with a molecular mass of ~ 55 kDa. Consecutive exons from 4 to 9 encode tandem arrays of epidermal growth-factor (EGF)-like domains. There is no EFEMP1 ortholog in non-mammalian species, indicating its recent evolution in higher vertebrates with intragenic exon duplications. There are 92-94% similarity at protein level among EFEMP1 of human, rat and mouse. |
Figure 2. Domain structures of EFEMP1 and modular gene structure for EGF-like domains based on variant 2. DSL, Delta-Serrate-Lag (DSL) motif is a motif unique to Delta/Serrate/LAG-2 proteins in addition to repeated copies of EGF motif (Lissemore and Starmer, 1999). | |
Description | EFEMP1 belongs to seven-member family of secreted glycoproteins characterized by a N-terminal signal peptide, a tandem repeat of EGF-like domains and a unique C-terminal fibulin-type module. |
Expression | EFEMP1 is broadly expressed throughout the body during development and in adult tissues. It is highly expressed by epithelial and endothelial cells. |
Localisation | Extracellular matrix. |
Function | EFEMP1 is one member of fibulins that serve to modulate cellular behavior and functions by connecting and integrating multiple partner molecules in extracellular compartment. EFEMP1 is likely to contribute the integrity of basement membrane zones and anchor other extracellular matrix structures such as elastic fibers to basement membranes. Studies based on Efemp1 knock-out mouse implicate EFEMP1 function in withholding tissue integrity by stimulating the expression of Timp1 and Timp3 and inhibiting the expression and activities of matrix metalloproteinase Mmp2, and Mmp9 (Rahn et al., 2009). EFEMP1 interacts with TIMP3 (Klenotic et al., 2004) and hepatitis B virus X antigen (Sun et al., 1998). EFEMP1 suppresses endothelial cell spouting and antagonizes angiogenesis in vivo (Albig et al., 2006). EFEMP1 interacts with EGFR (Camaj et al., 2009). However, opposing effects from EFEMP1 on EGFR-AKT signaling activity were reported in different cancer cells, to promote (Camaj et al., 2009) or suppress (Hu et al., 2011; Hwang et al., 2010; Kim et al., 2012) cancer cell migration/invasion and/or in vivo tumor growth. A Delta-Serrate-Lag motif in EGF-like module with insertion has been revealed to be responsible for EFEMP1-mediated activation of Notch signaling in glioma cells (Hu et al., 2012). |
Homology | EFEMP1 shares homology with the other members of fibulin family on (EGF)-like domains and fibulin-type module. |
Mutations |
Germinal | A single mutation of EFEMP1 gene at R345W was identified in patients with Malattia Leventinese (ML) and Doyne honeycombe retinal dystrophy (DHRD) (Stone et al., 1999). Severe atropy of the retina was observed in patients with this mutation, including absence of photoreceptor and RPE cells, and large fibrous scars in the macular region. This mutation was reported to cause protein misfolding, so that it is secreted inefficiently and retained within cells (Marmorstein et al., 2002). Comparison of pathological features of Efemp1 knockout and R345W knock-in mice suggests R345W mutation in causing macular degeneration is not due to loss of EFEMP1, so it is likely that the mutation has an added detrimental effect that alters Bruch's membrane to a greater extent than other structures (Fu et al., 2007; McLaughlin et al., 2007). |
Implicated in |
Note | |
Entity | Brain cancer |
Note | EFEMP1 was found to be highly expressed in malignant gliomas and in glioma cells with activation of Notch signaling (Hu et al., 2012; Hu et al., 2009). However, EFEMP1 expression is positively associated with survival of patients with the highest grade of glioma - glioblastoma multiforme (GBM) and consistently, EFEMP1 was shown to suppress highly proliferative GBM cell growth in vivo by attenuation of EGFR-AKT signaling activities and VEGFA-induced angiogenesis (Hu et al., 2011). Along with activation of Notch pathway, EFEMP1 was shown to enhance migration/invasion and growth in vivo by glioma cells high in Notch signaling and stem-like feature (Hu et al., 2012). The contradictory roles of EFEMP1 to the growth of different glioma cells suggest EFEMP1 context-dependent function, thus could be an interesting gene to study glioma initiation, progression and tumor heterogeneity. |
Entity | Breast cancer |
Note | Hypermethylation of EFEMP1 promoter was found to be the major cause of EFEMP1 expression down-regulation in 50-60% sporadic breast cancer (SBC). Tumor suppressive function of EFEMP1 is implicated in SBC by a favorable prognosis effect of EFEMP1 expression to survival, particularly node-positive patients who received adjuvant anthracycline-based chemotherapy, but not in those treated by either cyclophosphamide-methotrexate-5-fluorouracil (CMF) or tamoxifen (Sadr-Nabavi et al., 2009). |
Entity | Cervical cancer |
Note | EFEMP1 protein expression was found to be significantly higher in cervical carcinoma with lymph node metastasis and correlates with poor patient survival (En-lin et al., 2010). Tumor-promoting effect of EFEMP1 in cervical cancer is supported by its function in promoting growth in vivo and in vitro invasion by cervical cancer cell line Hela (Song et al., 2011). |
Entity | Colorectal cancer |
Note | Hypermethylation of EFEMP1 promoter was reported in 38,8% colorectal cancer (CRC), which is correlated with downregulation of EFEMP1 expression and cancer progression to advanced pathological stage with lymph node metastasis. Tumor suppressive function of EFEMP1 is implicated in CRC by a favorable prognosis effect of EFEMP1 expression to overall survival and disease-free survival (Tong et al., 2011). |
Entity | Liver cancer |
Note | Hypermethylation of EFEMP1 promoter was reported in 50% hepatocellular carcinoma (HCC), which is correlated with downregulation of EFEMP1 expression. Tumor suppressive function of EFEMP1 is implicated in liver cancer by unfavorable prognosis from promoter methylation of EFEMP1 (Nomoto et al., 2010). |
Entity | Lung cancer |
Note | Hypermethylation of EFEMP1 promoter was independently reported by two laboratories in 36% and 43% of non-small cell lung carcinoma (NSCLC), while it was rarely found in the matched normal samples (Wang et al., 2010; Yue et al., 2007; Zhang et al., 2011). It is correlated with downregulation of EFEMP1 expression and cancer progression to advanced pathological stage and lymph node metastasis. Tumor suppressive function of EFEMP1 in lung cancer cell is demonstrated by its suppression effect on anchorage independent growth and in vitro invasion via suppression the expression of matrix metalloproteinase, including MMP2, MMP7, and MMP9 (Kim et al., 2012). |
Entity | Nasopharyngeal carcinoma |
Note | Hypermethylation of EFEMP1 promoter has been revealed in nasopharyngeal carcinoma (NPC) tumours compared with normal tissues. Downregulation of EFEMP1 expression was found in NPC at advanced lymph node-metastasis stages and a poor 5-year survival rate. Tumor suppressive function of EFEMP1 in NPC is revealed by suppressing migration and invasion of NPC-derived cells and correspondingly decreasing the AKT phosphorylation (Hwang et al., 2010). |
Entity | Pancreatic cancer |
Note | EFEMP1 was reported to bind EGFR and activate MAPK and AKT pathways in pancreatic carcinoma cells and promote in vivo tumor growth with a stimulation of VEGFA production by tumors (Camaj et al., 2009; Seeliger et al., 2009). |
Entity | Prostate cancer |
Note | Hypermethylation of EFEMP1 promoter was reported in 95,3% of prostate cancer (PCa) but 13,4% of benign prostate hyperplasia (BPH), and EFEMP1 expression was significantly higher in tissue samples from patients with BPH than in those with PCa (Kim et al., 2011). |
Entity | Werner syndrome |
Note | S1-5 mRNA is overexpressed in Werner syndrome and senescent human diploid fibroblasts (Lecka-Czernik et al., 1995). |
Entity | Adult height |
Note | The EFEMP1 locus is one of 20 loci identified in a genome-wide association analysis that influence adult height (Okada et al., 2010). |
Bibliography |
Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. |
Albig AR, Neil JR, Schiemann WP. |
Cancer Res. 2006 Mar 1;66(5):2621-9. |
EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. |
Camaj P, Seeliger H, Ischenko I, Krebs S, Blum H, De Toni EN, Faktorova D, Jauch KW, Bruns CJ. |
Biol Chem. 2009 Dec;390(12):1293-302. |
The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis. |
En-lin S, Sheng-guo C, Hua-qiao W. |
Gynecol Oncol. 2010 Jun;117(3):417-22. Epub 2010 Apr 7. |
The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice. |
Fu L, Garland D, Yang Z, Shukla D, Rajendran A, Pearson E, Stone EM, Zhang K, Pierce EA. |
Hum Mol Genet. 2007 Oct 15;16(20):2411-22. Epub 2007 Jul 30. |
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. |
Hu B, Nandhu MS, Sim H, Agudelo-Garcia PA, Saldivar JC, Dolan CE, Mora ME, Nuovo GJ, Cole SE, Viapiano MS. |
Cancer Res. 2012 Aug 1;72(15):3873-85. doi: 10.1158/0008-5472.CAN-12-1060. Epub 2012 Jun 4. |
Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. |
Hu B, Thirtamara-Rajamani KK, Sim H, Viapiano MS. |
Mol Cancer Res. 2009 Nov;7(11):1756-70. Epub 2009 Nov 3. |
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. |
Hu Y, Pioli PD, Siegel E, Zhang Q, Nelson J, Chaturbedi A, Mathews MS, Ro DI, Alkafeef S, Hsu N, Hamamura M, Yu L, Hess KR, Tromberg BJ, Linskey ME, Zhou YH. |
Mol Cancer. 2011 Sep 28;10:123. |
Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity. |
Hwang CF, Chien CY, Huang SC, Yin YF, Huang CC, Fang FM, Tsai HT, Su LJ, Chen CH. |
J Pathol. 2010 Dec;222(4):367-79. |
Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation. |
Kim EJ, Lee SY, Woo MK, Choi SI, Kim TR, Kim MJ, Kim KC, Cho EW, Kim IG. |
Int J Oncol. 2012 Feb;40(2):402-8. doi: 10.3892/ijo.2011.1191. Epub 2011 Sep 7. |
EFEMP1 as a novel DNA methylation marker for prostate cancer: array-based DNA methylation and expression profiling. |
Kim YJ, Yoon HY, Kim SK, Kim YW, Kim EJ, Kim IY, Kim WJ. |
Clin Cancer Res. 2011 Jul 1;17(13):4523-30. Epub 2011 May 13. |
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations. |
Klenotic PA, Munier FL, Marmorstein LY, Anand-Apte B. |
J Biol Chem. 2004 Jul 16;279(29):30469-73. Epub 2004 Apr 28. |
An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis. |
Lecka-Czernik B, Lumpkin CK Jr, Goldstein S. |
Mol Cell Biol. 1995 Jan;15(1):120-8. |
Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG-2 (DSL) proteins. |
Lissemore JL, Starmer WT. |
Mol Phylogenet Evol. 1999 Mar;11(2):308-19. |
Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. |
Marmorstein LY, Munier FL, Arsenijevic Y, Schorderet DF, McLaughlin PJ, Chung D, Traboulsi E, Marmorstein AD. |
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13067-72. Epub 2002 Sep 19. |
Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice. |
McLaughlin PJ, Bakall B, Choi J, Liu Z, Sasaki T, Davis EC, Marmorstein AD, Marmorstein LY. |
Hum Mol Genet. 2007 Dec 15;16(24):3059-70. Epub 2007 Sep 13. |
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis. |
Nomoto S, Kanda M, Okamura Y, Nishikawa Y, Qiyong L, Fujii T, Sugimoto H, Takeda S, Nakao A. |
Ann Surg Oncol. 2010 Mar;17(3):923-32. Epub 2009 Nov 7. |
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. |
Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N. |
Hum Mol Genet. 2010 Jun 1;19(11):2303-12. Epub 2010 Feb 26. |
Failure of pelvic organ support in mice deficient in fibulin-3. |
Rahn DD, Acevedo JF, Roshanravan S, Keller PW, Davis EC, Marmorstein LY, Word RA. |
Am J Pathol. 2009 Jan;174(1):206-15. Epub 2008 Dec 18. |
Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. |
Sadr-Nabavi A, Ramser J, Volkmann J, Naehrig J, Wiesmann F, Betz B, Hellebrand H, Engert S, Seitz S, Kreutzfeld R, Sasaki T, Arnold N, Schmutzler R, Kiechle M, Niederacher D, Harbeck N, Dahl E, Meindl A. |
Int J Cancer. 2009 Apr 1;124(7):1727-35. |
EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma. |
Seeliger H, Camaj P, Ischenko I, Kleespies A, De Toni EN, Thieme SE, Blum H, Assmann G, Jauch KW, Bruns CJ. |
Mol Cancer Res. 2009 Feb;7(2):189-98. Epub 2009 Feb 10. |
EFEMP1 expression promotes angiogenesis and accelerates the growth of cervical cancer in vivo. |
Song EL, Hou YP, Yu SP, Chen SG, Huang JT, Luo T, Kong LP, Xu J, Wang HQ. |
Gynecol Oncol. 2011 Apr;121(1):174-80. Epub 2010 Dec 15. |
A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. |
Stone EM, Lotery AJ, Munier FL, Heon E, Piguet B, Guymer RH, Vandenburgh K, Cousin P, Nishimura D, Swiderski RE, Silvestri G, Mackey DA, Hageman GS, Bird AC, Sheffield VC, Schorderet DF. |
Nat Genet. 1999 Jun;22(2):199-202. |
Identification of a protein isolated from senescent human cells that binds to hepatitis B virus X antigen. |
Sun BS, Zhu X, Clayton MM, Pan J, Feitelson MA. |
Hepatology. 1998 Jan;27(1):228-39. |
Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis. |
Tong JD, Jiao NL, Wang YX, Zhang YW, Han F. |
Neoplasma. 2011;58(5):441-8. |
Aberrant promoter methylation of FBLN-3 gene and clinicopathological significance in non-small cell lung carcinoma. |
Wang R, Zhang YW, Chen LB. |
Lung Cancer. 2010 Aug;69(2):239-44. Epub 2009 Nov 12. |
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. |
Yue W, Dacic S, Sun Q, Landreneau R, Guo M, Zhou W, Siegfried JM, Yu J, Zhang L. |
Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4336-44. |
Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. |
Zhang Y, Wang R, Song H, Huang G, Yi J, Zheng Y, Wang J, Chen L. |
Cancer Lett. 2011 Apr 1;303(1):21-8. Epub 2011 Jan 20. |
Citation |
This paper should be referenced as such : |
Zhou, YH |
EFEMP1 (EGF containing fibulin-like extracellular matrix protein 1) |
Atlas Genet Cytogenet Oncol Haematol. 2013;17(2):115-120. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Genes/EFEMP1ID49818ch2p16.html |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Mar 14 13:39:49 CET 2017 |
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text: Jim Rome Is Somewhat Displeased With The Amount Of Money His Horse "Mizdirection" Brings InJack Dickey8/21/11 4:00pm17EditPromoteGo to permalinkNo, we did not know that ESPN annoyance Jim Rome owned a horse. But we are not surprised that the horse's name has a Z in it. Becuz that'z juzt what Jim Rome duz, broz.


text: Lionel Messi Accused Of Tax FraudBarry Petchesky6/12/13 9:33amFiled to: lionel messibarcelonataxesgettypic381EditPromoteShare to KinjaToggle Conversation toolsGo to permalink A Spanish prosecutor has formally filed a complaint against Barcelona striker Lionel Messi and his father, accusing the two of submitting fraudulent tax returns for four years. Advertisement According to a spokesperson for the prosecutor's office, Messi and his father Jorge defrauded the state of more than $5.3 million from 2006-2009. The complaint was filed in Gava, outside Barcelona, where Messi lives.Exact figures are hard to come by, but reports had Messi's 2009 Barcelona contract paying him $14 million a year, and a 2012 raise paying him $16 million annually. Advertisement [Reuters, h/t @TheBaumer]Reply38 repliesLeave a reply


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Hi everyone....just stopping in to let you all know that I have been working over the weekend to get some pieces ready to go in the shop for Monday. {I am hoping to put more pieces in over the next few weeks too but shall start off with about 10 or so pieces} I am terribly excited, for no other reason than I have actually managed to design a banner for my Etsy Shop at long last....it is a great feat for me, as I am no whizz on the computer and for once, managed what I actually intended. hurrah ;)))
The prints I had planned won't be ready in time for early next week I shouldn't think....so we shall see if they make it in the mix for the holidays or whether they spring up another time...
So, for Monday..look forward to some necklaces with pierced silhouettes in silver, oxidised brooches, fine pearl charm bracelets, and several styles of earrings....all limited edition or one off.
Hope everyone is having a good weekend so far...I am off tonight to see the new James Bond film at the flicks.
Sunday, November 19, 2006
Getting ready....
4 comments:
- MYRIADE said...
Your`e pieces are beautiful! Where could i possibly get them?
- 9:33 pm
- Anonymous said...
Oh, I'm soooo excited Abigail! I can't wait to see your new jewelry and prints!!! I promise to reply to your email request for photos soon. My sweet horse chestnut earrings are lovely :)
xo, Maryellen - 2:31 am
- kelly said...
good morning abigail! i'm looking forward to visiting your shop later :) well done on your banner...it looks really nice. did you enjoy bond? we went on sat night (how packed was the cinema??!) + i have to say i thought it/he was excellent from the opening credits right to the end! have a great week! x
- 7:59 am
- Paul O Mahony said...
Yes nice banner indeed. I'm interested that you use Etsy. I've been amazed by the quality of the craft on Etsy and the relatively low prices. Have you used it for long? Would love to know what your experience is with it?
I'm not a craftsperson myself but I have some friends who use Ebay, and I'm just wondering would it be worth convincing them to switch to Etsy. - 12:12 am


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Poway Teachers Protected From Budget Ax
Monday, February 28, 2011
Aired 3/1/11
Poway teachers will be protected from the budget ax. The Poway Unified School District is one of a few school districts that will not issue layoff notices in March.
Poway teachers will be protected from the budget ax. The Poway Unified School District is one of a few school districts that will not issue layoff notices in March.
Roughly 1,500 Poway teachers will keep their jobs despite the state's money problems.
Poway district officials say they're using one-time federal and state stimulus funding to balance their budget this year.
Most importantly, school officials say their teachers have agreed to pay cuts and furlough days over the past three years, saving the district money.
This year teachers are working eight fewer days and taking a 4 percent salary rollback.
Superintendent John Collins said the union and the district work together in what's called Interest Based Problem Solving.
"For example, (teachers) want class sizes lower, we have that interest too," Collins said. "As you go through these priorities, you realize what they want are things that we want too because we're all working for a good system for our kids."
Poway teachers union leaders are also part of a national group called the Teacher Union Reform Network, which seeks to reform the way unions negotiate and approach education reform in public school systems.
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Meredith made wonderful crostini smeared with soft goat cheese drizzled with white truffle oil and garnished with fresh thyme. Divine. They were so nicely presented with a sprig of fresh thyme atop. And, more truffle oil to drizzle at our pleasure! We all loved them.
Scott made a wonderful Tuscan Kale Salad. I am now calling it Scott's Kale Salad. So simple and amazing. I will be making this every time I find fresh kale at the market. I loved it. The kale was so nice and tender and delicately flavoured with the vinaigrette. You can see it in the middle bowl of the picture above.
Scott's Kale Salad
4 - 6 cups kale, juliennedjuice of 1 lemon
2 cloves garlic, mashed
3 - 4 tablespoons extra virgin olive oil
salt, pepper, hot pepper flakes
2/3 cup grated pecorino, asiago or parmesan cheese
1/2 cup toasted panko bread crumbs
Make a vinaigrette with the lemon juice, garlic, olive oil, salt, pepper and hot pepper flakes. Toss with the julienned kale. Top with grated cheese and panko. Serve. (This can be made up to an hour in advance with great success).
So this is our plate. Beautiful fresh green beans marinated in a tarragon vinaigrette, Scott's Kale Salad, fingerling potato salad with fresh garden peas and Salt Spring Island mustard sauce dressing, and tandoori chicken. What is not showing is the wonderful lamb sausage with carmelized onion chutney.
What is a picnic without a fire? It was a cold and windy day. The fire kept us at the beach for at least three hours. |
The rugged French Beach on the Strait of Juan de Fuca on Vancouver Island. |


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2 responses
Richard Hawkins gave props (12 Jul 2012):
gentle mist ! great pose
Saroj Swain gave props (15 Jul 2012):
missed some one!!! Great shot and great expression....


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Ohio Moms
Did your mom put an orange in the bottom of your stocking to fill out the foot?
by mem82
December 6, 2012 at 11:48 AM
Seems like this was a fairly common tradition. Mine did.
Do you do it for your kiddos?
I didn't even have a stocking growing up!! But I put an orange in my daughters and an apple in my son's. He couldn't handle the acid from the orange and still can't... I am going to try a stocking with Tailer this year. She has autism and she doesn't pay attention to the stocking. It's hard enough, it takes us all day for her to open gifts. We don't get her many because we usually buy her things through out the year.At Christmas she opens 1 gift and has to play with it for a while. So cute


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Since the school system is currently in a 3-days-surrounding a weekend version of Fall Break, I took the Flute Player up the road to the new discount/department store that opened a bare 4 miles from our house. She has grown like nobody's business in the past six months and was in need of jeans and at least one pair of dressy pants that covered her ankles. And I just haven't had time to get any patterns adjusted for her; she's been growing faster than I could get the adjustments made so we were going for emergency rations.
She took up residence in a fitting room while I ran around the store bringing her various styles and sizes.
Which means I got a pretty good look at the merchandise in the juniors and misses sections of the store.
O.Mi. Gosh. What a bunch of...dreck. Cheap, thin, wonky, card-boardy and EXPENSIVE. We did find two pairs of jeans, one pair of (thin) RPL pants (that will need to be hemmed up a couple of inches) and some loungy/sweat pants. All on sale..and it still rang up at about $120.
I want to clear my calendar, take two weeks off from work and just sew that child a wardrobe. Quick-like, before she grows more. And then make one for myself.
At least our fabrics will feel nice.
On a more positive note, I found out a few weeks back that Louise Cutting will be teaching a one-day seminar for the Birmingham chapter of the American Sewing Guild on the first Saturday in November (and she will be bringing fabric!!). Miss A and I are making plans to go; I sent in my registration today.
I haven't done a sewing event in a really long time; it'll be nice to see Louise again and get some inspiration.
But I really, really want to spend some quality time with my sewing machine...unfortunately, I've some mending/alterations that need to be done before I can really get there. Sigh.
There are no big events scheduled for this weekend; I think I can at least knock some of those out. I hope.
Thursday, October 06, 2011
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Religion & Spirituality, Christianity
FollowChristianity | 50 |
Religion & Spirituality | 59 |
Enjoying Everyday Life® is a daily TV and radio broadcast provided by Joyce Meyer Ministries.
October 11th, 2015
Episode 380 of 740 episodes
We need to know the Word of God well enough to recognize the enemy's lies and respond with the truth from the Word.
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Caroline Feraday and Claire Bullivant on Brits in Hollywood, and Hollywood through the eyes of Brits.


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A Roll Of Ektar
This week's roll is Ektar 100, a fantastic color negative film that I ran through the M3. The Ektar sports some really fine film grain as well as fantastic color reproduction. Pretty happy with the film overall.
I've been getting a few questions about how I process and scan each roll. Simple answer? I take all my film to Light Waves Imaging, a full service professional lab here in San Francisco where I get all my film processed, scanned, and printed. I can even get very uncommon formats processed, like the 127 I shoot with my old Ansco. Their chemistry is spot on, and I'm always thrilled with the results I get from their services. Here are most of the shots from my latest roll of Ektar:
Leica M3 + 50mm f/1.4 Summilux | Leicameter MC | Kodak Ektar 100
14 Responses
Love the pup. Great photos.
you're right, fantastic colors for this Ektar!
Always Suki's lovely! -
Yes, so true, I absolutely love the colors! Cool images.
Fantastic! Thanks for reminding me of a word that I haven't a spoken in about 20 years… Ektar…
beautiful photos.
do you find you need to do any post processing in LR once you get them back
just got a m6. can't wait to give it a spin.
Hi Bijan,
Most of these have no post processing applied. Sometimes I'll adjust the blacks to taste, but other than that, these are the scans as I originally got them from Light Waves. They're a great lab!
These are beautiful! I love the warmth of the tones. Autumn light in this city is so gorgeous. For some reason, I really like the photo with the fan. There's something so authentic-feeling when you see a picture of a vintage item taken with a vintage camera!
love your wife's glasses! Seagull photos are cool. And are those Fall leaves in Cali?
Yup! They're rare, but we do get some fall leaves =)
Your photos are always so crisp and captures the perfect moment! Would be great if you could take a look at my work as well! =)
Thanks everyone!
Beautiful colours!
How gorgeous is film?! I'll have to check out Light Waves; I finally finished a roll of film (only took a year…!) and am looking for a good developing lab.
Beautiful photo's. Your dog is lovely ! 🙂


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tuition and fees
View a breakdown of our tuition and fees and see how we compare to major universities.
Go to Tuition and Fees »
FAFSA Information
Seminole State College Student Services is here to help you with your financial aid questions. Here's how to contact our office:
Student success specialists are available to assist you at all four campuses:
Sanford/Lake Mary Campus | Altamonte Springs Campus |
Student Affairs (Building A) |
850 South SR 434 Altamonte Springs, FL 32714 View map and directions |
Heathrow Campus | Oviedo Campus |
1055 AAA Drive Heathrow, FL 32746 View map and directions |
2505 Lockwood Blvd. Oviedo, FL 32765 View map and directions |
The Financial Aid Office will be closed (no processing) on the following days in 2014-15:
Financial Aid Office 407.708.2045 fax: 407.708.2323
Federal School Code: 001520


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A BMW has taken the overall win at the Pacific Northworst 24 Hours of LeMons, but it wasn't yet another dime-a-dozen E30. Nope, the winner this time was the bigger and more dignified E28 5 Series.
An El Camino-ized E28 won the notorious "demolition derby LeMons" at Altamont in '07, and quite a few E28s have contended for a LeMons win on laps since that time. Finally, a long-overdue E28 victory. Now it's the E23's turn!
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PubMatic avait besoin d'un nouveau design de logo et a lancé un concours sur 99designs.
Un gagnant a été sélectionné de 32 designs proposés par 13 designers freelance.
PubMatic Premier
PubMatic is a global Ad Revenue Optimization company that provides premium online publishers (sites like CNN.com, Wall Street Journal, and more) with a full service solution to manage and monetize non-guaranteed online ad inventory. PubMatic's technology ensures that online publishers get the most money from their advertising space by deciding in real-time which ad network or exchange can best monetize each impression.
Large, premium publishers such as CNN, Wall Street Journal, EBay, and more.
We need a logo for the PubMatic Premier product, which is aimed specifically at high-end publishers. Please feel free to use your creativity, but make sure that the logo ties in well with our current logo and website (which can be found at http://www.pubmatic.com). Our current logo needs to be part of the new PubMatic Premier logo and needs to maintain the same fonts and colors. However, the word "Premier" and any associated graphics are left to your creativity. The look and feel should tie in well with the style of our website, and should be similar. I'd like to incorporate the PubMatic blue (also found on the website) in some way but am open to other color options.
Please see the current PubMatic Premier Logo--this is what you'll be redesigning.


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David and Paul Richardson are now friends 3 years, 1 month ago
Paul Richardson commented on the post, 2013 F1 testing day 6 in pictures 4 years, 1 month ago
wow – messed up that link! also meant fit the aero rack and the vanity panel at the same time!
Paul Richardson commented on the post, Turkish government says no to funding for race 4 years, 3 months ago
I agree with you – then I looked at the picture and while I respect that he has been in the business for years, and had a decent career, but you can tell why it was babble. I'm surprised nobody told him his […]
Paul Richardson replied to the forum topic Sky F1 coverage in 2012 in the group F1 4 years, 3 months ago
Not that this means a lot to Sky but their current F1 Competition includes a a year's subscription to Sky World and the HD Pack. Georgie annouced the competition on the F1 Show as a way of watching all the […]
Paul Richardson joined the group F1 4 years, 3 months ago
Paul Richardson commented on the post, Silverstone success would bode well for Red Bull's season 4 years, 8 months ago
I thought it all stemmed from Mark giving his new front wing to Vettel when Vettel smashed his up in FP. I think at the time the team claimed it suited Vettel's driving style more. Amazing how we all remember […]
Paul Richardson commented on the post, The Bahrain Grand Prix: A matter of conscience 4 years, 11 months ago
So being caught in the middle of a petrol bomb attack – granted not aimed at them but still a physical attack by a crowd of protesters is somehow less frightening or severe them someone threatening violence? I […]
Paul Richardson became a registered member 5 years ago


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Pack info
- Pack created on: Dec. 31, 2006, 7:30 a.m.
- Number of sounds: 2
- Number of downloads: 501
See more packs by yewbic
2 sounds
I didn't know what to call this sample.. so I just called it what it was. This started out as ...
I wrote and designed this little "abstract-piano" piece exclusively for TheFreeSoundProject. Haven't seen too many abstract-type piano sounds out there, ...
2 sounds


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Re-live a night of plaintive Appalachian folk with live performances from the American raga-inspired drone band PELT... Opened with a solo set from PELT member Nathan Bowles and a plaintive post-folk set from Mike Gangloff and Matt Peyton.
DISCLAIMER: THIS VIDEO FEATURES FLASHING LIGHTS Amnesia Scanner debut a new audio-visual project at the Institute of Contemporary Arts in London.
Strictly analogue jams from Space Afrika in episode 1 of Ruf Kutz TV...
Recent Young Turks signee NOLIFE performs an ear-splitting set live from a souped-up car in Gillet Square.
NTS brought Ottawa rapper Night Lovell (previously known as KLNV) to Kamio for a heavy set. Check it.
Re-watch the Neverland Clan get live at Kamio, warming up for Night Lovell's London show...
The iconic Genesis Breyer P-Orridge of Psychic TV and Throbbing Gristle performs live from Cafe Oto with Aaron Dilloway, co-founder of Detroit noise legends, Wolf Eyes.
The official music video for God Colony's 'Turn My G Down', produced in collaboration with vocalist Stash Marina; and the first in an audio-visual series from NTS and God Colony.
Abstract electronics and martial industrial music from the collaborative duo, Dale Cornish and Phil Julian. Broadcast live from Cafe Oto.
Re-live the inimitable Kojey Radical performing at The Crofter's Rights at Bristol.
Bristol rapper ThisisDA performs for his co-curated show with NTS at The Crofter's Rights.
NTS presents the new video for Prayer's new track, 'FADING', off his latest release, 'LOST'.


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NEW YORK (MarketWatch) — U.S. stocks on Friday sealed a second week of gains as the Federal Reserve's bond-buying program fueled demand for riskier assets including the euro and commodities.
"We had a fair amount of data out right on the heels of the Fed, but probably the biggest influence today is still the after-effects of the Fed's announcement yesterday," said Jim Baird, chief investment strategist at Plante Moran Financial Advisors.
UnitedHealth replaces Kraft on Dow 30
UnitedHealth Group will replace Kraft Foods in the Dow Jones Industrial Average, in a shift driven by Kraft's plan to spin off its North American grocery business. Polya Lesova discusses the impact on Markets Hub. Photo: Getty Images.
The dollar fell, oil prices neared $100 a barrel and Treasurys declined as the plan by Fed Chairman Ben Bernanke and his U.S. central bank colleagues spurred investor demand for riskier assets.
Stocks have been climbing for much of the recent summer, rallying around 4% in the last two weeks. "A good amount of this move was the fact that Europe has moved away from its Lehman moment," said Bill Stone, chief investment strategist at PNC Wealth Management.
Scaling back from a 113-point climb, the Dow Jones Industrial Average DJIA, -0.29% gained 53.51 points, or 0.4%, to 13,593.37, the highest close since Dec. 10, 2007. It gained 2.2% on the week, tallying gains for eight of the past 10 weeks.
Bank of America Corp. BAC, +0.22% rose 1.6% on the day and was up 8.5% this week, bolstered by the Fed's decision Thursday to expand its long-term securities holdings with unlimited monthly purchases of $40 billion of mortgage debt. Read more on the Fed's plans.
"What [European Central Bank President Mario] Draghi is doing in Europe and what Bernanke is doing here is good news. They've effectively said that too little, too late is the most regrettable lament in the lexicon of central banking," said Hugh Johnson, chairman of Hugh Johnson Advisors LLC in Albany, N.Y.
Effective Sept. 24, UnitedHealth Group Inc. UNH, -0.18% will replace Kraft Foods Inc. KFT in the blue-chip Dow in the wake of Kraft's plan to spin off its North American food-store business. Kraft shares ended down 0.5%. Read more UnitedHealth's next step.
Up 1.9% from the week-ago close, the S&P 500 SPX, -0.08% gained 5.78 points, or 0.4%, to 1,465.77, with energy performing best of its 10 industry groups after crude-oil futures CLV2, +0.18% topped $100 a barrel for the first time since May. Read about oil's rise.
Back to 1987
for stocks?
Our Trading Deck has been home to a spirited debate over whether we're in for a crash.
• L.A. Little: Don't worry | Michael Gayed: Worry
• The warning signs of a 1987-style crash
• Hulbert: Stocks as overvalued as at 2007 high
"It's better to sell bonds and get into something that is going to give you a return. The Fed is forcing investors to get out of safer investments; the search for yield is going to drive up the price of commodities, including oil," said Phil Flynn, senior market analyst at Price Futures Group in Chicago.
The S&P 500 has also gained for eight of the 10 past weeks.
The Nasdaq Composite COMP, +0.19% climbed 28.12 points, or 0.9%, to 3,183.95, the highest close since Nov. 9, 2000. Apple Inc. AAPL, -0.20% shares rose $8.30, or 1.2%, to $691.28. Read more on Apple.
The dollar DXY, +0.00% fell against other currencies, including the euro EURUSD, +0.1484% Read more on currencies.
The yield on the 10-year Treasury note TMUBMUSD10Y, +0.00% rose to 1.868%, up 15 basis points, for the biggest one-day rise in six months. Read more on bonds.
The price of gold GCZ2, +0.79% also gained as investors hedged against future inflation, with the metal finishing the floor session up 60 cents at $1,772.70 an ounce. Read more on gold futures.
For every stock falling more than two gained on the New York Stock Exchange, where nearly 900 million shares traded. Composite volume of 4.89 billion surged past the year-to-date average daily volume of 3.64 billion.
Friday's data showed U.S. retail sales rising along with the cost of living in August, both reflecting increased costs for gasoline. Read more on retail sales.
Industrial production contracted last month as consumer confidence unexpectedly brightened in September, with climbing stocks and home prices helping to bolster sentiment and offset escalating gasoline costs. Read more on industrial production and more on consumer sentiment.
"The positive gains have certainly helped out individual portfolios, and we've also had some positive news on the housing front nationally, so there are at least some early signs that perhaps we're starting to turn the corner there, which is a real positive," said Baird at Plante Moran.
"The other side of the coin would be the industrial production numbers that showed some softening there," Baird added.
The market has likely cast "too bright a light on underlying numbers, the economy continues to expand, but at a very slow pace," said Johnson, adding that the market's rise is based on its interpretation that central-bank actions are "going to be positive for the economy and earnings."


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Maxwells DIY is a chain of home improvement and DIY stores in North East England. Everything from timber, screws, plumbing to tools, flooring, tiles and furniture can be found at Maxwells DIY. For opening hours and closing times to nearest Maxwells DIY, look no further.
Mon: | 09:00-17:30    | Fri: | 09:00-17:30 |
Tue: | 09:00-17:30    | Sat: | 09:00-17:30 |
Wed: | 09:00-17:30    | Sun: | Closed |
Thu: | 09:00-17:30    |
In the UK there are several large chains selling products for DIY and Home and Garden. Homebase, Screwfix, Toolstation, Wickes, Wilko and The Range are some of the larger hardware store chains. Then there is the Mica Hardware chain of co-operative DIY stores. Opening hours to a store nearby can be found on these pages. Most Do-it-yourself stores sell tools, building parts, joinery, Kitchen & Bathroom supply, Screws, nails & fixings, Electrical & Lighting, Heating & Plumbing, Sealants, Adhesives, Auto parts and much more.
Find Opening Times for Maxwells DIY in Sunderland
Find Opening Times for Mace Stores in Sunderland
Find Opening Times for Heals in Sunderland