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Best Fishing Times: 6:15AM to 8:15AM, and 9:32PM to 11:32PM
Alternate Fishing Times: 9:02AM to 11:02AM
Fishing Clam Lake, AK on 2/25/2017 will be best from 6:15AM through 8:15AM, and from 9:32PM to 11:32PM. If those times won't work for you, 9:02AM to 11:02AM looks promising. Remember to adjust these times based on barometric pressure, and weather changes.

subset: commoncrawl


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Exploiting the crosstalk between 2 immune-modulating cytokines may help combat tuberculosis (TB), reports an international team of researchers (Mayer-Barber KD et al. Nature. 2014;511[7507]:99-103). The scientists discovered that IL-1 confers host resistance to TB by stimulating lipid-derived signaling molecules known as eicosanoids that limit excessive type I interferon (IFN) production to help contain Mycobacterium tuberculosis infections.
In infected mice and patients, reduced IL-1 responses, excessive type I IFN responses, or both were linked to an imbalance of eicosanoids and to worsening of disease. Treatment with clinically approved drugs that augment levels of prostaglandin E2, an eicosanoid, promoted bacterial killing and prolonged survival in infected mice.
Hampton T. Immune Molecules Affect Tuberculosis Outcomes. JAMA. 2014;312(5):477. doi:10.1001/jama.2014.9185
© 2017


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Silencing and re-expression of retinoic acid receptor beta2 in human melanoma
This article is corrected by:
- Errata: Erratum Volume 23, Issue 5, 722, Article first published online: 20 August 2010
Richard M. Niles, e-mail: email@example.com
Many melanoma cells are resistant to the anti-proliferative effect of all trans retinoic acid (ATRA). Retinoic Acid Receptor-β2 (RAR-β2) mediates the ATRA growth inhibition. We found a correlation between the anti-proliferative activity of ATRA and expression of RAR-β2. There was not a strict correlation between DNA methylation of RAR-β gene and its expression. There was no difference in global and RARβ specific nucleosome repeat length (NRL) in melanoma and melanocytes or between control and ATRA treated cells. Pan-acetylation of H3 and H4 within the RAR-β gene promoter was higher in cells expressing RAR-β2. All trans retinoic acid treatment of responsive cells did not change pan-acetylation of H3/H4, but addition of ATRA to non-responsive cells increased H4 pan-acetylation. Phytochemicals or the histone deacetylase inhibitor Trichostatin A did not restore expression of RAR-β2. Treatment of WM1366 melanoma cells with 5-aza 2′-deoxycytidine reactivated RAR-β2 gene expression and restored the ability of ATRA to further induce the expression of this gene. Therefore, promoter methylation is responsible for silencing of RAR-β2 in some melanoma cells and pan-acetylation of H3 likely plays a permissive role in expression of RAR-β2.


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Finally, after months of beta trials, Samsung Pay is going official in Malaysia. This is a mobile payment service that allows you to make payments at card terminals using your Galaxy smartphone. Initially available only for Maybank VISA card holders, Malaysian Samsung Pay users will soon be able to cards issued from other banks and networks.
After seeing Maybank Pay and CIMB Pay, Samsung Pay is finally rolling out in Malaysia. It isn't officially launched yet but Samsung has commenced Beta trials in partnership with Maybank. With Samsung Pay, you can make debit/credit card payments using your Galaxy smartphone.
Suria KLCC was alive with the sound of roaring fans as Samsung officially launched the Galaxy S7 edge locally, though, we suspect more fans were roaring because of South Korean superstar Lee Kwang Soo, the phone got some hype too I'm sure. Besides the phone launch, Samsung also revealed that two big things would hit our shores later this year — Samsung Pay and the Gear 360.
Good news! You can now put that fingerprint sensor on your Samsung Galaxy device to, even more, use than before as the South Korean electronics giant has announced at their Samsung SEA Forum 2016 that Samsung Pay will be coming to the Southeast Asian regions this year.


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What Does 9/11 Have to Do with Going to College
As kids prepare to head back to college, or go off for the first time, parents are getting ready to say their goodbyes–and upping their data plans. The Los Angeles Times reports that going to college post-9/11 is much different than it was 10 years ago. The teary goodbyes may be the same, but 10 minutes down the road parents or kids are bound to hear the tell-tale alert of a text message, phone call, or even iPhone Face Time. These days parents and kids are able to be in touch nearly 24/7.
The post-9/11 world has led to an understandable rise in anxiety on the part of both parents and their college-age children. Kids going to school now were still in elementary school when the terrorist attacks occurred and parents and kids are naturally concerned about being separated. However, some experts say that the possibility of constant contact could be hindering the development of a natural healthy distance between parent and child. "[College students] may not know what to do with time and solitude," said Barbara Hofer, a Middlebury College psychology professor and author with Abigail Sullivan Moore of the book The iConnected Parent. What's more, the students never really separate from their parents enough to make their own decisions.
A survey conducted at two colleges showed that parents and students were in contact an average of 13 times a week. Some argue that the contact is doing nothing more than strengthening the lifelong bond of parent and child, and in most ways is simply a sign of changing times. Whatever the psychological effect, as the 10 year anniversary of 9/11 rolls around, more parents will be happy they have the ability to be in such close contact with their child when her or she is no longer home for dinner every night. What do you think? Is constant contact hindering your child's growth or merely serving to ease your fears?
Source: Latimes.com
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