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Paris Fashion Week Street Style
Category - Celeb Style
Gisele Bündchen for Vogue Paris October 2015 by Mario Testino Photographer: Mario Testino Stylist: Emmanuelle Alt Hair: Christiaan Houtenbos Make-up: Stéphane Marais
André Leon Talley gets Kanye West to open up about the influence of fatherhood and his future plans for the Yeezy collection in this exclusive after-show fashion fireside chat.
From Barbados to global stardom, Rihanna brings boldness to training as she prepares for the stage.
Beyonce shut down Made In America and now has photos from her sexy shoot with Flaunt magazine hit the net.
FKA Twigs Gigi Hadid
Pharrell for Harper's Bazaar Man Korea September 2015
GQ previews their shoot with The Weeknd in which he wore clothes from the "Yeezy Season 1" collection.

subset: commoncrawl


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Buildron (com.skahal.buildron) is a Mac software application that has been discovered and submitted by users of Software.com. The latest version that our users have reported running on their systems is Buildron 1.5.0. The most popular version of this application used by our users is Buildron 1.6.0.
Operating System: Mac
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Bundle Information: Buildron 1.0. (c) 2012 Skahal Studios. All rights reserved.


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- 1GB 128-Bit DDR2
- Core Clock 625 MHz
- 1 x DVI 1 x HDMI
- 48 CUDA Cores
- PCI Express 2.0 x16
noizy and hot 08/08/2010
This review is from: ASUS GeForce GT 220 DirectX 10.1 ENGT220/DI/1GD2(LP) 1GB 128-Bit DDR2 PCI Express 2.0 x16 HDCP Ready Low Profile Ready Video Card
Good picture and sound quality through hdmi, Easy to set up with drivers from Nvidia website, Compact design doesn't take two slots.
The fan makes awful noize!! can't even take it no more, hate this card! Even it spins all the way, the heatsink remains hot. Reaches temperature 80-85C in load. The heatsink design could be better for heat reduce purposes. I couldn't find driver for Windows 7 64x on supplied CD and wouldn.t suggest to download them on asus website, you'll get error messages, go to Nvidia websitefor them.
Other Thoughts:
I've chosen this car because of thin compact design which is rare for low profile cards. Would fit in my Dell Optiplex 755, but this fan screws everything up. Asus has should been though more how to choose quality fans.
1 people found this review helpful. Did you? Yes / No Thanks for the valuable feedback you provided!


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Looking for 1 (or 2 as I will be travelling with someone) rooms from May to August. I don't need anything fancy but I do require it to have a kitchen, bathroom and be in a safe neighbourhood. Anyone know of any good places to start looking?


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May 31, 2013
Photo Gallery | Video Highlights
Friday's Results
Become a Fan of Virginia Rowing on Facebook
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UPDATE - Saturday 5 a.m.: Saturday's schedule has been back to an 8:30 a.m. start. The Cavalier V8 will go off at 9:10, with the 2V8 at 9:40 and the V4 at 10 a.m.
INDIANAPOLIS, Ind.--The fifth-ranked Virginia rowing team advanced all three boats to the semifinals on the first day of the NCAA Championships Friday morning (May 31) on Eagle Creek Park Lake in Indianapolis, Ind.
On a rainy and windy morning, the Cavaliers' Varsity Eight and Varsity Four picked up victories in their respective heats, while the Second Varsity Eight placed second in its heat to qualify for Saturday's semifinals, which begin at 8:30 a.m., with the V8 followed by the 2V8 and the V4. Live results and live video links will be available and linked through VirginiaSports.com.
The top three teams from each semifinal will advance to Sunday's grand finals (places 1-6), while the last three will move onto the petite finals (places 7-12) on Sunday.
"To have all three boats advance to the semis and not have to come back for the repechages is awesome and a good first step for us," UVa head coach Kevin Sauer said.
"The morning went as well as we hoped it could go," assistant coach Brett Sickler said. "We've had three weeks since the ACC Championships and we changed it up and looked at a lot of (lineup) combinations, but the biggest thing we talked about with the team was leaving egos at the door and putting the team first. Everybody did that this morning and that's why we were able to be successful in all three boats."
The Varsity Eight started slow, but had gained a solid lead by the halfway point of the race and earned the victory in a time of 6:49.64, ahead of Washington (6:56.88), Michigan (7:02.31), Wisconsin, Gonzaga and Rhode Island. The fourth-seeded UVa boat posted the second-fastest time out of the four heats (USC - 6:48.94).
In the Second Varsity Eight, the Cavaliers jumped out to a lead on top-seeded Ohio State, but Buckeyes had a strong second half to edge UVa, 6:50.74 to 6:55.79. Yale was third in 6:59.43, followed by UCLA and Washington State. OSU and UVa, seeded eighth, notched the top two times over the four heats.
The Cavalier Varsity Four started strong and never looked back, winning in a time of 8:02.09, ahead of Yale (8:06.89), Brown (8:15.68), Harvard, Boston University and Marist. The 11th-seeded Virginia boat posted the fourth-fastest time, behind only USC (7:52.32), OSU (7:55.26) and Washington (8:02.09).
"The Varsity Eight was close at the start, but stretched out the lead to the finish, so that was a good race for them," Sauer said. "Our 2V8 really took it to the top seed Ohio State and was able to finish second and qualify straight to the semifinals, which was big, and our Varsity Four exhibited an awesome race to win their heat."
For live updates on UVa's races from Indianapolis, follow @UVaRowing on Twitter.
Virginia Lineups
Varsity Eight: Coxswain Sarah Jordan, Stroke: Constanze Duell, 7: Chandler Lally, 6: Kristine O'Brien, 5: Sarah Cowburn, 4: Fiona Schlesinger, 3: Susanne Grainger, 2: Hemingway Benton, Bow: Elle Murray
Second Varsity Eight: Coxswain Molly Frear: Stroke: Maddie Hilbrant, 7: Ann Reid, 6: Lizzy Youngling, 5: Chelsea Adams, 4: Kaitlin Fanikos, 3: Caroline Burke, 2: Betsy Nilan, Bow: Veronica Jones
Varsity Four: Coxswain Alissa Hornung, Stroke: Hannah Yoest, 3: Catherine Multari, 2: Nina Vascotto, Bow: Emily Pik
UVA Athletics Information
In the NewsRecent Headlines News Archives
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Weekend Notebook: Perrantes Hits HomestretchMen's Basketball2/24/17For point guard London Perrantes, the final regular-season road game of his UVA basketball career is Saturday afternoon at NC State.Casey's Return Buoys CavaliersBaseball2/22/17Derek Casey, who missed the 2016 season while recovering from Tommy John surgery, pitched five strong innings in No. 14 Virginia's home opener.Perrantes Searching for AnswersMen's Basketball2/21/17Senior point guard London Perrantes has made only 16 of 58 shots (27.6 percent) from the floor in his past four games, all Virginia losses.
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A 1985 graduate of UVA, White worked at the Richmond Times-Dispatch until July 2009. He was honored six times as the state's Sportswriter of the Year.
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Virginia Rowing Announces 2017 Schedule
W. Rowing | 1/26/2017
The seven-time defending Atlantic Coast Conference champions will compete in seven regattas,...
Virginia Takes Both Races at Rivanna Romp
W. Rowing | 11/13/2016
The Virginia rowing team concluded its fall season with a pair of victories at the Rivanna Romp...
Cavaliers Host Rivanna Romp on Sunday
W. Rowing | 11/11/2016
The Virginia rowing team concludes its 2016 fall schedule on Sunday morning (Nov. 13) by hosting ...
Virginia Places Second at Princeton Chase
W. Rowing | 10/30/2016
Brown won the Varsity Eight race with a time of 14:14.672 to defeat runner-up Virginia who came...
Princeton Chase Next For UVA Rowing
W. Rowing | 10/28/2016
The Virginia rowing team travels to Princeton, N.J., to compete in the Princeton Chase on Sunday ...
V8 Places Fourth Among Collegiate Boats at HOCR
W. Rowing | 10/23/2016
Virginia's Varsity Eight finished fourth among collegiate boats in the Championship Eights ...
UVA Opens Fall Season at the Head of the Charles
W. Rowing | 10/21/2016
The 52nd edition of the Head of the Charles will feature 2,260 crews and 10,600 athletes...
UVA Rowing Announces Captains
W. Rowing | 09/29/2016
Seniors Ellen Pate, Georgia Ratcliff and Grace Tuttle (Vienna, Va.) have been named tri-captains ...
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The Tanya Reclining Living Room Group by Best Home Furnishings from Darvin Furniture. We proudly serve the Orland Park, Chicago, IL area. Product availability may vary. Contact us for the most current availability on this product.
It's easy to find furniture that pleases everybody with the chic recliners from the Tanya collection. For those that crave comfort and those that demand high style, the Tanya collection has both, with a unique reclining design that mimics the look of a stationary sofa. It's so clever the way the seats look like removable cushions but conceal the plush, full-support chaise legrest of a recliner. Easy-to-use power recline is included on each piece with metal touch buttons in an antiqued brass finish. Finally- recliners that you'll be glad to show off to your friends!
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If you are in the UK or EU, VAT will be added at checkout.
Included in the price:
- Full ownership of the .com domain
- One of the 3 logo designs shown here (digital files supplied)
A smart brand name with real gravitas
An incredibly smart brand name. The Cap- beginning could refer to capital - as in financial capital, or to a capital city, or an architectural capital, found at the top of a column or pillar. The -egis ending could come from the word strategic but could equally refer to aegis - which means protection or support (for example, 'under the aegis of the UN'). With such powerful references, Captegis is a brand name with real authority.
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KEYWORDS | C | capital | money | finance | private equity | hedge fund | accountant | adviser | advisor | financial | corporate | consulting | consultant | consultancy | management | architect | architecture | fintech | strategy | strategic |


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Question: "I'm a 22-year-old, gay, Afro-Caribbean man living in the U.S. Virgin Islands, and I'm at my wits' end in trying to find friendship and companionship. No visible community exists here, and I doubt an underground community exists, either. Online attempts to find "friends" have been disappointing. I'm at a point where I've realized that what I need most now is emotional and physical intimacy, but I'm in a place where this is most unlikely to be found. I'd love to move to a city with thriving communities, like D.C. or NYC, but I lack the resources to do this. How do I cope with this loneliness?"
- Get out of Dodge. Even if it's a challenge and seems difficult, it will give you a goal to aim for. You should be around people of your own sensibilities and interests. A large percentage of the Caribbean can be very anti-nurturing for gay people, and you probably have very little support there.
User-recommended services:
- Downelink.com is an online LGBT community that allows users to interact with one another through social networks and resources. Both the site and app are free.
Photo: IStockPhoto.com
This article originally appeared on Advocate.com.
Steven Petrow is the author of Steven Petrow's Complete Gay & Lesbian Manners and can be found online at gaymanners.com. Got a question? Email him at firstname.lastname@example.com, or contact him on Facebook and Twitter.
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The popular chat show 'Koffee with Karan' is in its fifth season and host Karan Johar has managed to get the Khan brothers – Salman, Sohail and Arbaaz, for the 100th episode of the show. While Sohail and Arbaaz will be gracing the couch for the first time, it is Salman's second time on the show....read more
Arbaaz Khan News
Seems like Salman Khan is not completely over with his ex-girlfriend Katrina Kaif. The duo had been in a romantic relationship for a long time before breaking up in 2010, the ex-flames have maintained cordial ties. Salman talked about his love life on the special 100th episode of 'Koffee w...read more
After attending the first counselling session, Arbaaz Khan was spotted with a blonde driving to a plush restaurant in Bandra. From the picture, it can be concluded that post filing for divorce with estranged wife Malaika Arora, Arbaaz Khan has moved on in life. The 49-year-old was spotted ...read more
The Khan brothers of Bollywood – Salman, Sohail and Arbaaz are set to share the couch on popular chat show 'Koffee with Karan 5'. Salman himself confirmed about it with a tweet late last night. The 'Sultan' actor shared a picture of him with brothers Arbaaz and Sohail, and host Karan Johar...read more
Malaika Arora Khan and Arbaaz Khan have filed for divorce in the first week of November and as per the rule the estranged couple appeared before the court on 29th November for the first counselling session. As per the report, the couple handled the counselling session at Bandra family ...read more
Estranged couple Malaika Arora Khan and Arbaaz Khan finally reached Bandrafamily court for the first counselling session. The divorce proceedings of the couple started and the duo was spotted at the family court dressed in white outfit. After 18 years, Malaika and Arbaaz called it a quit. The cou...read more
Arbaaz Khan and Malaika Arora Khan have finally made up their mind to part ways. The estranged couple moved the Bandra family court seeking divorce. They have filed for divorce with mutual consent last week. Malaika Arora Khan and Arbaaz Khan's separation came as a big shock for the indust...read more
Separated couple Malaika Arora Khan and Arbaaz Khan reunited at son's Arhaan's birthday. The entire Khan parivaar was together on Wednesday night to ring in Arhaan's 14 birthday. Chachu Salman Khan was absent. Despite troubled relationship, Arbaaz and Malaika made sure that their son had a...read more
Reports of trouble in the paradise of Malaika Arora and Arbaaz Khan started doing the rounds since the beginning of the year. A few months later, the couple issued a joint statement confirming that they were living separately. Soon after, reports surfaced that Malaika and Arbaaz decided to...read more
Malaika Arora Khan and Arbaaz Khan were living separately for quite sometime due to their troubled marriage but strangely on Karwa Chauth the estranged couple were spotted together for an intimate dinner. Arbaaz and Malaika were clicked exiting popular Bandra eatery, Royal China, at midnig...read more


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This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
This book contains the proceedings of a symposium held in Munich, Germany, in connection with the 12th International Congress of Microbiology. In general, the papers were summaries or state-of-the-art discussions about a particular topic rather than the presentation of newly generated research data.
The first section is on the subject of dimorphism. Professor K. Kashkin presented a lengthy and extremely interesting review of the changes in antigen mosaic of an organism while undergoing morphologic transition. He extrapolated these antigenic changes to changes in composition, physiology, and, particularly, the appearance or disappearance of particular enzymes. These findings may help, in part, to unravel the bewildering diversity of antigen systems that occur during mycotic infections and their inconsistencies from patient to patient.
In a second section on ecological aspects of mycotic diseases, a particularly noteworthy contribution was made by Dr M. P. English. She has reported the changing occurrences of particular anthropophilic
Rippon JW. Medical Mycology: Proceedings of Mycological Symposia of the XII International Congress of Microbiology. Arch Dermatol. 1981;117(4):248. doi:10.1001/archderm.1981.01650040064029
© 2017


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Jethro Tull are one of the most successful British acts of all time with a career reaching from the late sixties to the present day. In 2003 they made their first (and so far only) visit to the Montreux Festival. Split into a semi-acoustic first half and a full on electric second half, the concert was a triumph combining newer songs such as 'Dot Com', 'Pavane' and 'Budapest' with classic favourites. As ever Ian Anderson leads from the front with his instantly recognizable voice and inimitable style of one-legged flute playing.
© 2017 Stingray Digital Media Group. All rights reserved. "ICONCERTS", "STINGRAY" and other related marks and logos are trademarks of Stingray Digital Media Group in Canada, the United States of America and other territories.


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Though sampling several outdoor activities can be exciting, it isn't something that every traveler desires. Thus, despite the fact that Casa Isleña Inn doesn't have the widest variety of recreational activities, it may still provide exactly the type of atmosphere you're trying to find.
There is one pool at Casa Isleña Inn. Lounging by the pool might not be a crucial part of your itinerary, but it can be an easy enough way to unwind and relax. Also consider that this property is located right on the beach, so there's a few different places to keep cool in the sun when you room here.
While there isn't a golf course at Casa Isleña Inn, you may be able to arrange a tee time during your stay. There are two golf courses in the area -- both are within 11 miles of Casa Isleña Inn. They are Borinquen Golf Club and Punta Borinquen Golf Club. The nearest of these is Borinquen Golf Club, since it's just a cab trip away from the property. This par 72 course is 6392 yards long.
Although your children are always welcome at Casa Isleña Inn, there aren't very many amenities that are specifically targeted at families. To find some places with more amenities of particular interest to kids, take a look at these properties recommended for families.
One of the amenities is on-site live entertainment, so even when visitors stay "in" for the night they won't be missing out. Typically, live entertainment is offered 3 to 4 days per week. Of course, the frequency may vary. If you want to learn more about their on-property entertainment, call the front desk at (787) 823-1525.
You'll also find a bar on-site — the best place to unwind before heading out to your next activity.
On top of what's available right on this property, guests who enjoy getting out 'n' about can find many interesting things to see and do in Puerto Rico. Whether you're looking to spend time on a sunny beach or enjoy a round on the golf course, you'll find plenty of other options for recreation in the region. Click on these links to learn more regarding riding a bike or moped, shopping, snorkeling, diving, fishing, sightseeing, and other activities you might enjoy.
Help us improve! We welcome your corrections and suggestions.


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text: i think i blew a blood vessel today. i don't smoke and hate my guys smoking on the site, but they do. the bigger problem i have is them throwing cig butts on the ground. what kind of smoking/no smoking policies do you guys have. i also don't allow smoking in the trucks. the way i figure, smokers cost me money, about $1,000 per year. can't dig a hole if you got a square in one hand, right.


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The first Lytton Springs was made in 1972 from vines planted at the turn of the century on the eastern half of the vineyard. The vineyard is planted to Zinfandel and complementary varietals on gravelly clay soil.
The wine is a blend of Zinfandel, Petite Sirah, Carignane, and Mataro (Mourvedre). Grapes are sustainably grown, hand harvested, destemmed and crushed, fermented on the native yeasts, and followed by full malolactic on the naturally occurring bacteria.
On the nose are aromas of ripe blackberry, pepper, licorice and a hint of vanilla. There is concentrated plum and black cherry fruit on the palate with supple tannins, minerality and balanced acidity. The finish is long and layered with notes of ripe fig and dried herbs.
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Gaudreau Environnement Inc
Since selective collection does not allow for retrieving all materials that can be reclaimed, Gaudreau provides ecocentre services where the population can dispose of construction and renovation materials as well as leaves, grass, branches, furniture, wood, metal, cardboard, brick, asphalt, concrete or other surpluses they might have
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Coolidge has 7,786 residents. It is located in Pinal county.
LVN schools in Coolidge charged students an average tuition of $1,736.00 if they were Arizona residents, and $7,728.00 if they were non-residents, during the 2009 - 2010 school year.
Books and supplies for lvn schools in Coolidge cost an average of $1,300.00. The average cost for room and board for students living on campus at lvn schools in Coolidge was $4,786.00. The average cost for students living at home was $4,000.00 for the 2009 - 2010 school year. Students have a choice of one lvn college in Coolidge to attend. LVN programs in Coolidge reportedly graduated 37 students in the 2008 - 2009 school year.
|Average Salary
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|Licensed Practical and Licensed Vocational Nurses


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Crowds Converge on Oktoberfest 2013
By Ted AYALA
One often hears Montrose's small town atmosphere touted by both residents and visitors alike. It isn't uncommon for people to refer to the area as a real-life counterpart to the fictional Mayberry of Andy Griffith fame. Cynics might think the notion an improbable one given the area's location – on the periphery of [...]
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150 A , SUNITA Bungalow, Daulat Ram Mandir Lane, Mukund Nagar, Pune - 411 037, Maharashtra, INDIA.
Sanskriti Housing Society is one of the popular residential developments in Wakad, neighborhood of Pune. It is among the completed projects of its Builder. It has lavish yet thoughtfully designed residences.
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Yep totally praying for awesome fert results but hey I also know by now that means absolutely nothing! I feel amazing! Apart from being nauseous and spacey- after a sleep I'm all ok! I've never not been in agony post EPU and normally need a good 4 days to recover. Hooray! My anaesthetist was also totally amazing. Fingers crossed this all means 4th stim was the charm.
@Heyside oh no good luck with the clexane. Fingers crossed for your Fet I didn't realise they can still PGD embryos after they have been frozen on day 5/6?


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4:18 pm
December 29, 2011
Got quite a scare when I lifted the condensation tray this morning and this popped out in front of me ... /huh.gif" style="vertical-align:middle" emoid=":huh:" border="0" alt="huh.gif" /> /laugh.gif" style="vertical-align:middle" emoid="" border="0" alt="laugh.gif" />
C. balansae flower. Never had anything but Anubias flower before, hope it means its happy and healthy and not about to die on me, which is my usual with plants.
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Clyde Douglas "Bulldog" Turner (March 10, 1919 – October 30, 1998) was a professional football player for the Chicago Bears. Wikipedia
From this profile you will find 10 photos, 35 lists, and key facts about Bulldog Turner!
Bulldog Turner is a member of the following lists: 1998 deaths, American football offensive linemen, 1919 births, American football linebackers, Pro Football Hall of Fame inductees, College Football Hall of Fame inductees, Hardin–Simmons University alumni, American football centers, Chicago Bears players and Head coaches of American football.
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Tesla car cost
How Electric Cars (and the Tesla Model S) Work
Beautiful Tesla S Model. Only $75,000 to go green? Is it worth it?
Life's a gas! But doesn't have to be. This infographic shows a cost comparison between gas, hybrid and electric cars.
This is the one we've been waiting for. At a more affordable price, Tesla presents his Model III.I think we're going to try to do something more radical,' says Elon Musk, creator of Tesla Motors, whose charging stations will power your Tesla for free, forever. This one, the Model III could be available in 2017, but more likely the middle or end of 2018. It's 20% lighter than the Model S and much cheaper. The $35,000 (USD) price tag slashes the $60,000+ price of the Model S.It will charge…
After riding in Uber's self-driving car I think Tesla will have some serious competition (tsla)
It's not the fastest production car ever made. But it is the third, and unlike the LaFerrari and Porsche 918 Spyder, it doesn't cost a million plus. The Tesla Model S P100D is Elon Musk's latest road rocket. Fueled by...
"Tesla Turbine Operation" - Rather than using blades and friction, the Tesla Turbine uses parallel, closely spaced disks that tap viscosity. Aerodynamic skin adhesion effect resists fluid or gas flow between plates, resulting in energy transfer to the shaft. The technology has been proven to work but is yet to break into marketplace in a cost-effective version.
Renault need to bring these concepts to market, bold and brash is exactly what the automotive industry needs right now
Elon Musk Says Tesla Model 3 Will Cost $35,000 Before Incentives 1/14/15
The Sasson Report: Chevrolet Bolt EV costs half the price of a Tesla,...


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Li L.,University of Sichuan |
Wu J.,Chongqing Cancer Hospital |
Sima X.,University of Sichuan |
Bai P.,University of Sichuan |
And 7 more authors.
Tumor Biology | Year: 2013
Growing evidence indicates that tumor suppressor gene TP-53 and non-coding RNA miR-34b/c independently and/or jointly play crucial roles in carcinogenesis. We hypothesized that the polymorphisms of rs4938723 in the promoter region of pri-miR-34b/c and TP-53 Arg72-Pro may be related to the risk of nasopharyngeal carcinoma (NPC). We performed a case-control study between 217 patients with NPC and 360 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A significantly increased risk of NPC was observed in the miR-34b/c rs4938723 CT/CC genotypes compared with the TT genotype (adjusted OR = 1.44, 95 % CI 1.02-2.03, p = 0.04), and also the C allele (adjusted OR = 1.33, 95 % CI 1.04-1.70, p = 0.03). The gene-gene interaction of miR-34b/c rs4938723 and TP-53 Arg72-Pro showed that the combined genotypes of rs4938723CT/CC and TP-53CG/CC increased the risk of NPC (rs4938723CT/CC + TP-53CG/CC vs. rs4938723 TT + TP-53 CG/CC: OR = 1.58, 95 % CI 1.04-2.42, p = 0.03). These findings suggest that miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may singly or collaboratively contribute to the risk of NPC. © 2013 International Society of Oncology and BioMarkers (ISOBM). Source
Yu W.,Kunming General Hospital of Chengdu Military Command |
Li G.,Third Military Medical University |
Wang D.,Chongqing Cancer Hospital
Chinese Journal of Clinical Oncology | Year: 2014
Objective: To observe the effect of the proteininhibitor of activated STAT 3 (PIAS3) on the proliferation and apoptosis of U251 glioma cells after PIAS3 expression was inhibited by RNAi. Methods: Three RNAi expression vectorstargeting PIAS3 were constructed and transfected into CHG-5 cells by liposomein vitro. The most efficient RNAi vector was subsequently selected by examiningthe mRNA expressions of PIAS3 in the transfected cells by semi-quantitativeRT-PCR. The selected RNAi vector was then transfected into U251 cells. After 48h of transfection, the mRNA and protein expressions of PIAS3 in glioma cellswere examined by semi-quantitative RT-PCR and western blot. Apoptosis wasobserved by flow cytometry using a double-staining method with FITC-conjugatedannexin V and PL Flow cytometry was also applied in cell cycle assay. Results: RNAidownregulated the mRNA (P<0.01) and protein (P<0.01) expressionsof PIAS3 in transfected cells.RNAi promoted the resistance of U251 cells to apoptosisand subsequently altered the cell cycle. A high percentage of G2 phaseand a low percentage of Sphase were observed in U251 cells. Conclusion: The downregulation of PIAS3arrested U251 cells in the G2 phase andinduced the resistance of U251 cells to apoptosis. Source
Ji H.,Kunming General Hospital of Chengdu Military Command |
Yu W.,Kunming General Hospital of Chengdu Military Command |
Li G.-H.,Chongqing Medical University |
Wang D.-L.,Chongqing Cancer Hospital |
Chen H.,Kunming General Hospital of Chengdu Military Command
Chinese Journal of Cancer Prevention and Treatment | Year: 2015
OBJECTIVE: To observe the effects of overexpression of protein inhibitor of activated STAT3(PIAS3) on the proliferation and apoptosis in CHG-5 glioma cells. METHODS: The constructed eukaryotic expression vectors of PIAS3 was constructed named as pEGFP-N1-PIAS3. In vitro the CHG-5 glioma cells were transfected with pEGFP-N1-PIAS3 with 01-igofectamine. At the same time, the blank control and negative control groups were set. After 48 hours, the expression of PIAS3 was analyzed by RT-PCR, western blots and immunohistochemistry. The apoptosis and proliferation of the transfected cells were analyzed by flow cytometry. RESULTS: The expression of PIAS3 in the transfected cells was increased. The change of cell shape and increased necrotic cells were observed by microscope. The IDV (Integrated density value) of PIAS3 mRNA (523 414.5±34 502.89) in the PIAS3-transfected group was significantly different from that of the blank control group (135 668.0±6 693.66) and the negative control group (154 511.67±8 266.89; χ2 = 13.053, P = 0.01). The IDV of PIAS3 protein (30.13±3.76) in the PIAS3-transfected group was significantly different from that of the blank control group (13.83±0.77) and the negative control group (15.02±0.87; χ2 = 14.193, P = 0.001). The results suggested that the expression of PIAS3 was increased in the PIAS3-transfected cells. The percentage of early apoptotic cells (12.5±1.9)% in the PIAS3-transfected group was significantly higher than that of the blank control group (6.4±1.1)% and the negative control group (5.4±1.8)% (χ2=7.407, P = 0.005). The rate of living cells (86.9±2.2)% was significantly lower than that of the blank control group (92.1±1.2)% and the negative control group (93.1±2.0)% (χ2=4.775, P=0.019). The percentage of the cells in S phase (35.2±4.2)% in the PIAS3-transfected group was significantly higher than that of the blank control group (24.5±5.1)% and the negative control group (23.0±3.7)%(χ2 = 8.179, P=0.003). The percentage of the cells in G2 phase (10.7±5.4)% in the PIAS3-transfected group was significantly lower than that of the blank control group (21.3±4.0)% and the negative control group (27.8±5.2)% (χ2 = 17.121, P<0.01). CONCLUSION: The overexpression of PIAS3 in CHG-5 glioma cells significantly suppresses cells proliferation, induces S-phase arrest and cell apoptosis. © 2015, Editorial Board of Chinese Journal of Cancer Prevention and Treatment. All right reserved. Source
Neferine increase in vitro anticancer effect of dehydroepiandrosterone on MCF-7 human breast cancer cells
Yang D.,Chongqing Cancer Hospital |
Zou X.,Chongqing University |
Yi R.,Chongqing University |
Liu W.,Chongqing Medical University |
Zhao X.,Chongqing University
Applied Biological Chemistry | Year: 2016
This study was conducted to investigate the in vitro anticancer reinforcing effects of neferine (Nef) on dehydroepiandrosterone (DHEA) and the mechanism was also determined during the investigation. By the growth effects of Nef and DHEA on MCF-7 human breast cancer cells, 8 mg/mL Nef was a non-virulent concentration in MCF-7 cells, and this concentration was used for further experiment. In 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay, 30 mg/mL DHEA showed 49.4 % growth inhibitory effect in MCF-7 cells, whereas Nef (8 mg/mL) + DHEA (30 mg/mL) treatment had the higher effect at 67.8 %. The flow cytometry analysis results showed that 15 and 30 mg/mL DHEA-treated MCF-7 cells had 12.2 and 21.6 % apoptotic cells, respectively, Nef + DHEA could raise the apoptotic cells to 36.7 %. Reverse transcription-polymerase chain reaction assay shows remarkable results according to which DHEA could significantly increase caspase-3, caspase-8, caspase-9, Bax, p53, p21, E2F1, Fas, FasL mRNA expressions and decrease Bcl-2, Bcl-xL, HIAP-1, HIAP-2, survivin expressions as compared to the untreated control cancer cells. Moreover, these effects depend on the concentration of DHEA, and Nef which could further strengthen these effects. From these results, low concentration of Nef could not influence the growth of MCF-7 cells, but using its sensitization effect, Nef raised the in vitro effects of DHEA. Nef could be got easily. With these results we can accomplish that Nef + DHEA might be used as the new anticancer materials combination. © 2016, The Korean Society for Applied Biological Chemistry. Source
Association of promoter polymorphism of apolipoprotein e gene with cerebral vasospasm after spontaneous SAH
Wu H.-T.,Zunyi Medical College |
Ruan J.,Chongqing Cancer Hospital |
Zhang X.-D.,Chongqing Medical University |
Xia H.-J.,Chongqing Medical University |
And 2 more authors.
Brain Research | Year: 2010
Cerebral vasospasm (CV) is the main complication of spontaneous subarachnoid hemorrhage (SAH), affecting clinical outcome of patients with SAH. Accumulating evidence indicates that apolipoprotein E (apoE protein, APOE gene) gene polymorphism is associated with prognosis of patients with SAH. The current study aimed to investigate the association of promoter polymorphism of APOE with CV in patients with SAH. One hundred and one patients with spontaneous SAH were involved in this study. Venous blood samples were collected to identify the promoter genotype of APOE by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). CV was judged by transcranial Doppler sonography (TCD) combined with patients' condition. Associations of APOE promoter polymorphism with CV after SAH were analyzed by χ2 test, uni- and multivariate logistic regression analyses. In 101 patients, 42 of 87 patients (48.3%) with promoter - 219T allele showed CV, which was significantly different from those with - 219G allele (23/61, 37.7%, P = 0.04). Uni- and multivariate logistic regression analyses also showed that promoter - 219T was a risk factor to predispose CV after SAH. However, there was no significant association between promoter - 491A/T (rs#449647) or - 427C/T (rs#769446) polymorphisms and SAH induced CV (P > 0.05). Our finding suggests that patients with APOE - 219T promoter are apt to CV after spontaneous SAH. © 2010 Elsevier B.V. All rights reserved. Source


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Suncadia features many seasonal events; Harvestfest each October, Winterfest from November through January, the Summer Concert Series and much more. View all upcoming and unique resort events here.
Elk Feeding at Nelson Farm Twice Daily 9:00am & 3:00pm Get an up-close look at Suncadia's resident herd of Elk during their twice daily feeding down at Nelson Farm. Get warm by the fire pit and enjoy the view, it is truly a majestic scene! FREE and Open to the Public
You don't want to miss the perfect RUN-CATION at Suncadia Resort in Cle Elum, Washington. One of the best hidden resorts in our state, with running trails, bike trails, dirt trails and a gorgeous resort overlooking the river. Join us in August with other fun athletes. WEEKEND SCHEDULE ...
Make a tee time reservation at one of our great golf courses!Member Tee Times Public Tee Times
Escape to the mountains for a nature-inspired experience at Glade Spring Spa, located in Suncadia Resort. Featuring outdoor mineral salt water soaking pools, steam rooms, saunas and sanctuary relaxation lounges, this 9500 sq. foot spa offers massage, skin care, body treatments, manicures, pedicures (natural nails) and spa cuisine.Make an Appointment
Make a reservation at one of our amazing restaurants!Reserve at Portals Restaurant


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Top Definition
I went inside only to find you jamming your joystick on the couch.
by artbee September 23, 2010
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


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Pendharkar P.C.,Information Systems
Engineering Applications of Artificial Intelligence | Year: 2010
In this paper, we propose a software defect prediction model learning problem (SDPMLP) where a classification model selects appropriate relevant inputs, from a set of all available inputs, and learns the classification function. We show that the SDPMLP is a combinatorial optimization problem with factorial complexity, and propose two hybrid exhaustive search and probabilistic neural network (PNN), and simulated annealing (SA) and PNN procedures to solve it. For small size SDPMLP, exhaustive search PNN works well and provides an (all) optimal solution(s). However, for large size SDPMLP, the use of exhaustive search PNN approach is not pragmatic and only the SA-PNN allows us to solve the SDPMLP in a practical time limit. We compare the performance of our hybrid approaches with traditional classification algorithms and find that our hybrid approaches perform better than traditional classification algorithms. © 2009 Elsevier Ltd. All rights reserved. Source
Pendharkar P.C.,Information Systems
Expert Systems with Applications | Year: 2012
We consider game-theoretic principles for design of cooperative and competitive (non-cooperative self-interested) multi-agent systems. Using economic concepts of tâtonnement and economic core, we show that cooperative multi-agent systems should be designed in games with dominant strategies that may lead to social dilemmas. Non-cooperative multi-agent systems, on the other hand, should be designed for games with no clear dominant strategies and high degree of problem complexity. Further, for non-cooperative multi-agent systems, the number of learning agents should be carefully managed so that solutions in the economic core can be obtained. We provide experimental results for the design of cooperative and non-cooperative MAS from telecommunication and manufacturing industries. © 2011 Elsevier Ltd. All rights reserved. Source
News Article
Site: http://news.mit.edu/topic/mitmechanical-engineering-rss.xml
With over 130,000 square feet of hands-on makerspaces, MIT has more of these facilities on its campus than anywhere in the world. Yet, according to findings from a student-wide survey conducted last summer, the top two places where MIT students make things are in their dorm rooms and off-campus. The reason? Students face too many barriers when trying to use MIT's expansive maker infrastructure. Students across the Institute need access to makerspaces not only for their studies but to work on personal and entrepreneurial projects. Rebecca Li, a junior majoring in mechanical engineering, notes that students often have to "hijack a club or lab's machine shop access, pay many different membership fees, or stumble into little known shops like MITERS [MIT Electronics Research Society] and Maker Works." According to Li, who helps manage the MITERS space as their facilities manager, the only way to find out about these options is effectively through referral. "If you are not involved in some builder club, lab, or group, you are unlikely to hear about all of the shops or what you have the ability to access," she says. In Aaron Ramirez's experience as a PhD student, new arrivals to MIT have little idea of what resources exist on campus and are often lost as to where to begin and where to turn to for help. "Many of the incoming students, including myself long ago, never had exposure to or training on machine tools, rapid prototyping equipment, or instrumentation. These tools are essential for engineering and for obtaining and improving your skills as an engineer — it's not just a hobby for us, it's our life and passion, and necessary for our development," he says. "Students have to put in a decent amount of effort to finally get access to the workshops, which is not trivial when you consider how much other stuff they have to do already, especially as a freshmen!" No one understands these hindrances more than Marty Culpepper, MIT alumnus, professor of mechanical engineering, and the recently appointed MIT "Maker Czar." He acknowledges that it can take a student up to nine months to get into a space and build anything, a startling statistic that doesn't sit well with him. "There are reasons why students have difficulty getting into these spaces," Culpepper says. "One barrier is knowing where everything is. Another is, how do you get trained, whom do you contact to get trained, and once you've been trained, do other shops know you've got that skill set? How do you pay for things if you need to pay for them? All of these things stacked on top of each other make it very difficult not only for students to get things done, but for faculty and their research to get done." In an effort to address the situation, Culpepper has been charged with determining the best ways to increase student access to campus makerspaces, which in part means breaking down these barriers in a myriad of ways. "We know that MIT students want to design and build things. We know this is important to their education and to their desire to start companies. We are here to fix the problem and the first step to doing that is with Mobius," says Culpepper. Designed to help the MIT community navigate a complex making system, the Mobius app (shown here), released March 4, enables users to search through the vast array of makerspaces and equipment on campus. (Christine Daniloff/MIT) Designed to help the MIT community navigate a complex making system, the Mobius app, released March 4, enables users to search through the vast array of makerspaces and equipment on campus. Developed in partnership with students, shop managers, alumni, and MIT's Information Systems and Technology office, the app is the first of its kind. It was realized through the support of the Lord Foundation of Massachusetts and MIT alumni Colin and Erika Angle, who recognized the potential of Mobius to transform the maker experience for MIT students. Available to download for iOS (with an Android version in development), Mobius will match users' needs to maker resource availability as well as assist technical staff in managing their shops and improving student communications and interactions. Students who use the app will be able to locate that laser cutter or mill they need for their project from the convenience of their mobile device, saving them time spent searching for information that is not available online. Using the app also eliminates the step of having to call or walk to each space for shop hours, policies, and training protocols. Li, who along with Ramirez worked with Culpepper to design the app, says that Mobius "will let people uncover which makerspace is both open and has the right machines for them." She continues, "Knowing where certain machines are on campus, or even that they exist, will help people get things done and make more things. The most important aspect of the app is the elimination of the unknown of whom to contact or whom to ask for access. People will feel more confident knowing that they are talking to the right person who can get them help, instead of playing email ping pong as their project gathers dust." Other key features of Mobius include the ability to pay for materials, machine time, and access fees directly through the app. Additionally, shop managers will be able to check a user's abilities with a built-in endorsement and flagging system, potentially allowing someone already skilled at machining and endorsed by another shop to fast-track their training to gain access in a different facility. In the future, users in turn will be able to rate their experience with a particular shop, providing helpful tips and advice to others in the maker community. For the last two years, Culpepper has spent his days learning about all of MIT's makerspaces and visiting other universities across the country to explore theirs. The experience was eye-opening, leading to the realization that while MIT boasted the most makerspace square footage, its utilization rate was underwhelming. Culpepper is determined to lead the future of making at MIT and beyond, with new technologies such as Mobius and other activities of the recently launched Project Manus. Initiated in October 2015 by MIT Provost Martin Schmidt and housed within the MIT Innovation Initiative, Project Manus will build capacity in MIT's makerspaces and foster the maker communities that will create the gold standard in next-generation academic maker systems. Lessons learned on the MIT campus — including Mobius — will be shared widely so students and staff at other universities can take advantage. "Today marks a very important first step in a journey to provide our community with seamless access to the vast maker resources on our campus, and to bring greater coordination of all these resources. In Mobius, and the other elements of Project Manus, Professor Culpepper has provided us with an exciting vision for the future and a roadmap to get there. I am grateful to Professor Culpepper and the MIT Innovation Initiative for advancing this critical effort to strengthen our innovation ecosystem," said Provost Schmidt upon the app's release. Culpepper, whose work is just beginning, remarks, "Mobius is just one of five major programs that Project Manus is working on to improve the way MIT supports students and makerspace staff. I invite everyone to visit the Project Manus web site to learn more."
News Article
Site: http://www.nanotech-now.com/
Abstract: Healthcare practitioners may one day be able to physically screen for breast cancer using pressure-sensitive rubber gloves to detect tumors, owing to a transparent, bendable and sensitive pressure sensor newly developed by Japanese and American teams. Conventional pressure sensors are flexible enough to fit to soft surfaces such as human skin, but they cannot measure pressure changes accurately once they are twisted or wrinkled, making them unsuitable for use on complex and moving surfaces. Additionally, it is difficult to reduce them below 100 micrometers thickness because of limitations in current production methods. To address these issues, an international team of researchers led by Dr. Sungwon Lee and Professor Takao Someya of the University of Tokyo's Graduate School of Engineering has developed a nanofiber-type pressure sensor that can measure pressure distribution of rounded surfaces such as an inflated balloon and maintain its sensing accuracy even when bent over a radius of 80 micrometers, equivalent to just twice the width of a human hair. The sensor is roughly 8 micrometers thick and can measure the pressure in 144 locations at once. The device demonstrated in this study consists of organic transistors, electronic switches made from carbon and oxygen based organic materials, and a pressure sensitive nanofiber structure. Carbon nanotubes and graphene were added to an elastic polymer to create nanofibers with a diameter of 300 to 700 nanometers, which were then entangled with each other to form a transparent, thin and light porous structure. "We've also tested the performance of our pressure sensor with an artificial blood vessel and found that it could detect small pressure changes and speed of pressure propagation," says Lee. He continues, "Flexible electronics have great potential for implantable and wearable devices. I realized that many groups are developing flexible sensors that can measure pressure but none of them are suitable for measuring real objects since they are sensitive to distortion. That was my main motivation and I think we have proposed an effective solution to this problem." ### This work was conducted in collaboration with the research group of Professor Zhigang Suo at Harvard University, USA. Collaborating institutions Osaka University Harvard University, USA Funding Japan Science and Technology Agency (JST) Exploratory Research for Advanced Technology (ERATO) Someya Bio-Harmonized Electronics Project About University of Tokyo The University of Tokyo is Japan's leading university and one of the world's top research universities. The vast research output of some 6,000 researchers is published in the world's top journals across the arts and sciences. Our vibrant student body of around 15,000 undergraduate and 15,000 graduate students includes over 2,000 international students. Find out more at www.u-tokyo.ac.jp/en/ or follow us on Twitter at @UTokyo_News_en. For more information, please click Contacts: Research contact Professor Takao Someya Department of Electrical Engineering and Information Systems Graduate School of Engineering The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan Tel: +81-3-5841-0411/6756 Fax: +81-3-5841-6709 Press officer contact Graduate School of Engineering Public Relations Office The University of Tokyo The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan Tel: 03-5841-1790 Fax: 03-5841-0529 If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
News Article
Site: http://www.scientificcomputing.com/rss-feeds/all/rss.xml/all
Rochester, NY — Cloud computing software has brought many changes to the business landscape and, currently, the implementation of such a service is common. New research sheds light on the growing competition between two widely used software models — Software-as-a-Service (SaaS), and Modified off-the-Shelf (MOTS) software. "The key factor that drives competitive business strategies in this highly aggressive market is the provider's pricing scheme," says Abraham Seidmann, Xerox Professor of Computers and Information Systems and Operations Management from the University of Rochester's Simon Business School. SaaS is available online on-demand, which allows businesses to increase production with fewer people. This scalability reduces investment on technology infrastructure, as well as easily maintaining access to important information with little to no upfront spending. SaaS is used in a number of common business areas with organizations, such as Workday, which offers cloud-based enterprise-level software solutions for human resources and financial management, QuickBooks offering cloud-based accounting solutions and DialogsCMS delivering enterprise content management. The typical in-house MOTS systems provide some API's (application program interface) with access to the source code of the underlying software so it can be customized and better integrated to the business. Cerner is an example of a health care technology vendor that develops customized Electronic Medical Records (EMR) to create a "custom fit" between the software and the needs of the medical institution. This vendor recognizes the need for customization and enhanced functionality, while a leading competitor, such as EPIC, seems to be far more limited in that respect. On the other hand, most SaaS systems provide limited customization options, because they are operating in a multitenancy environment. Multiple customers share the same application, running on the same operating system, hardware and data-storage mechanism. This is how SaaS attains economies of scale, but as a result, users might incur significant lack-of-fit and integration costs. According to Seidmann, "Paying more while not getting your exact business integration needs is called "lack-of-fit" cost. When lack-of-fit costs decrease — when new industry standards are adopted, for example — SaaS systems need to reduce prices to gain market share. However, when lack-of-fit costs are expected to increase, MOTS software will be more competitive, because it's easier to modify the source code to meet specific functional needs." In their paper, "Analyzing Software as a Service (SaaS) with Per-Transaction Charges," Seidmann and his co-author Dan Ma, Associate Professor Information Systems from Singapore Management University, built a game theory model to explore competitive pricing strategies of SaaS and MOTS platforms on a per-transaction basis to determine where and how each service modality gives end-users more value for their money. The co-authors identified three different qualities to measure the pricing strategies between competitors: Based on their analysis, the researchers offer three top strategic recommendations: Now that the cloud computing software trend seems unstoppable in many markets, major players in the competitive on-demand software game need to adapt to the changing times and offer both SaaS and MOTS options. The trend is already evident for companies, such as SAP, Microsoft and Oracle who feel the pressure by newcomers to the cloud space and, hence, offer both versions — hoping to convert a one-time sale into a perpetual income stream.


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Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.
IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238
- Online
- 1437-4331
Clinical chemistry reference values for 75-year-old apparently healthy persons
Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 11, Pages 1355–1360, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.247, November 2006
Publication History
- Received:
- June 21, 2006
- Accepted:
- August 25, 2006
- Published Online:
- 2006-11-07
Background: Clinical chemistry reference values for elderly persons are sparse and mostly intermixed with those for younger subjects. To understand the links between metabolism and aging, it is paramount to differentiate between "normal" physiological processes in apparently healthy elderly subjects and metabolic changes due to long-lasting diseases. The Vienna Transdanube Aging (VITA) study, which began in 2000 and is continuing, will allow us to do just that, because more than 600 male and female volunteers aged exactly 75 years (to exclude any influence of the "aging" factor in this cohort) are participating in this study.
Methods: Extensive clinical, neurological, biochemical, psychological, genetic, and radiological analyses, with a special emphasis on consumption of medication and abuse of drugs, were performed on each of the probands. The multitude of data and questionnaires obtained made possible an a posteriori approach to select individuals fulfilling criteria for a reference sample group of apparently healthy 75-year-old subjects for our study. Specific analytes were quantified on automated clinical analyzers, while manual methods were used for hormonal analytes. All clinical chemistry analytes were evaluated using in-depth statistical analyses with SPSS for Windows.
Results: In all, reference intervals for 45 analytes could be established. These include routine parameters for the assessment of organ functions, as well as hormone concentrations and hematological appraisals. Because all patients were reevaluated after exactly 30 months in the course of this study, we had the opportunity to reassess their health status at the age of 77.5 years. This was very useful for validation of the first round data set. Data of the second round evaluation corroborate the reference limits of the baseline analysis and further confirm our inclusion and exclusion criteria.
Conclusions: In summary, we have established a reliable set of reference data for hormonal, hematological, and clinical chemistry analytes for elderly subjects. These values will be very useful for our future attempts to correlate disease states and aging processes with metabolic factors.
Clin Chem Lab Med 2006;44:1355–60.
Keywords: clinical chemistry analytes; elderly; prognostic marker; reference interval
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About Our Staff
Lisa R. Hale, PhD
KCCAT Founding Director
Dr. Hale received her PhD in Clinical Psychology with a subspecialty in Health Psychology from Finch University of Health Sciences/The Chicago Medical School, as part of the Anxiety and Obsessive-Compulsive Disorders Treatment and Research Laboratory, and completed an APA accredited internship in Clinical and Health Psychology at Charleston Area Medical Center/West Virginia University School of Medicine. Her extensive research and clinical activities have centered on cognitive behavioral theories and interventions for anxiety and depression across all age groups, including intensive exposure-response prevention protocols for severe anxiety disorders and a dedication to mentoring other professionals in these techniques. Dr. Hale first began the Anxiety Research Program in 2004 while completing a fellowship at Hoglund Brain Imaging Center at the University of Kansas Medical Center, and created KCCAT in 2005 as a direct service specialty setting for the region. She has received funding through the National Institutes of Health and a number of clinical research and training contracts, served as a Research Assistant Professor in the Department of Neurology at KUMC, and currently holds appointment as an Adjunct Associate Professor in the Department of Psychology at the University of Missouri-Kansas City. She remains a strong advocate for education surrounding evidence-based treatment and increasing access to quality care. She has been a frequent consultant to local and national media, and an active member and presenter for a number of leading mental health organizations including the International OCD Foundation, the Selective Mutism Group, the Trichotillomania Learning Center, Association for Behavioral and Cognitive Therapies, and the Anxiety and Depression Association of America, holding an appointment on its Board of Directors for the 2011-2014 term. Under Dr. Hale's leadership, KCCAT was chosen as a 2011 honoree of the 25 Under 25® Awards—celebrating creative vision, responsible fiscal and operations management, and meaningful contributions to the community among Kansas City small businesses.
Jeff Jaeger, PhD
Associate Director
Senior Staff Psychologist
Dr. Jaeger received his PhD in Clinical Psychology from the University of Washington, with an emphasis in treating anxiety disorders and multi-problem clinical presentations. He completed an APA accredited internship in Clinical Psychology at the University of California–San Diego/San Diego Veterans Affairs Healthcare System and an APA accredited postdoctoral fellowship at the Durham VA Medical Center. Prior to joining KCCAT in 2014, he served as a Clinical Assistant Professor at the University of Iowa Hospitals and Clinics. Dr. Jaeger has extensive training in CBT for anxiety disorders in adults, with a particular expertise in providing individual and group treatment for Posttraumatic Stress Disorder (PTSD). Dr. Jaeger is also extensively trained in treating complex multi-problem clinical presentations with individual and group Dialectical Behavior Therapy (DBT). Dr. Jaeger's research interests and publications have predominately focused on trauma and PTSD issues, for which he received a National Research Service Grant Award from the National Institute of Mental Health. He is both a member and a presenter at the Association for Behavioral and Cognitive Therapies and the International Society for Traumatic Stress Studies.
Katie D. Kriegshauser, PhD
Associate Staff Psychologist
Director of Research and Training
Dr. Kriegshauser received her PhD in Clinical Psychology from Saint Louis University, with an emphasis in anxiety disorders and a specialty concentration in university teaching skills. She completed an APA-accredited internship in Clinical and Health Psychology at Charleston Area Medical Center/West Virginia University School of Medicine, and subsequently completed a two-year specialty fellowship at KCCAT. Dr. Kriegshauser's clinical interests have focused on evidence-based treatments for anxiety and associated health conditions in adolescents and adults—including the treatment of eating disorders, insomnia, and broader executive functioning difficulties. Her research and publication focus has been on experimental psychopathology of anxiety and factors contributing to effective treatment delivery and outcomes. As KCCAT's Director of Research and Training, Dr. Kriegshauser coordinates the center's research activities and oversees both our psychology student practicum and visiting trainee program for other disciplines. She is a member of and regular presenter at the Anxiety and Depression Association of America.
Ashley J. Smith, PhD
Senior Staff Psychologist
Dr. Smith received her PhD in Clinical Psychology from the University of Nebraska-Lincoln, with an emphasis in child/family psychology and a research focus on social anxiety in adolescents, She completed an APA accredited internship in Clinical Child and Pediatric Psychology at Children's Mercy Hospital, and a supervised postdoctoral experience at the Anxiety Disorders Specialty Clinic at Omaha Children's Hospital, later serving as a staff psychologist. Dr. Smith has been with KCCAT since 2009, and holds extensive experience in treating anxiety and related presentations across the life span. She provides clinical services for all ages, with particular interests in pediatric psychology and the overlap between anxiety and eating disorder symptoms. Dr. Smith maintains active professional roles as a committee member and frequent presenter for national conferences of the Anxiety and Depression Association of America, holds appointment as an Adjunct Assistant Professor in the Department of Psychology at the University of Missouri-Kansas City, and serves as KCCAT's Coordinator of Professional and Community Services and Outreach.
William Oakley, PsyD
Associate Staff Psychologist
Dr. Oakley received his Doctorate in Clinical Psychology from Midwestern University in Illinois, where he worked with the Center for Anxiety and Obsessive Compulsive Disorders at Alexian Brothers Hospital as part of his training. He completed an APA–accredited pre–doctoral internship at the Carson Center for Adults and Families in Westfield, MA, and conducted research at Brown University's Center for Alcohol and Addiction Studies, serving as a trainer in Motivational Interviewing (MI) and an intervention specialist on a federally–funded study. Dr. Oakley completed a year of Post-doctoral Fellowship with Cognitive & Behavioral Consultants of New York, focused on individual and group CBT and Dialectical Behavior Therapy (DBT), then completed an Advanced Postdoctoral year here at KCCAT specializing in CBT/ERP. He is both a member and a presenter at the American Psychological Association, the Association for Behavioral and Cognitive Therapies, the International OCD Foundation, and the International Motivational Interviewing Network of Trainers.
Heather Smith-Schrandt, PhD
Associate Staff Psychologist
Dr. Smith-Schrandt received her PhD in Clinical Psychology from University of South Florida, with a focus on anxiety and related interpersonal and family factors. She completed an APA-accredited internship at the James A. Haley VA in Tampa, FL, with additional rotations including pediatric health, female psychology, and couples/family therapy. While at USF she also was involved in providing services for school-based interventions, healthy weight/eating disorder clinics, and the selective mutism treatment group. Dr. Smith-Schrandt joins KCCAT in September 2015 following a Postdoctoral Fellowship in the Department of Pediatrics at the USF Rothman Center for Neuropsychiatry. Her formal specialized training in interventions for anxiety, mood, OCD, selective mutism, tic, and related disorders includes CBT/ERP, acceptance and commitment therapy (ACT), dialectical behavior therapy (DBT), comprehensive intervention for tics (CBIT), and habit reversal training (HRT). Dr. Smith-Schrandt regularly shares her work through publications and presentations, and holds membership in the Selective Mutism Group and the American Psychological Association. She provides clinical services to all ages of individual patients, couples, and families.
Lindsey Murray, MA, LCP
Professional Staff Therapist
Ms. Murray received her Master's degree in Clinical Psychology with an emphasis in Child & Families at Roosevelt University in Chicago. She completed her BA in Journalism & Strategic Communications at the University of Kansas along with a focus in Psychology. Her prior research and focus was in evaluating the efficacy of a transitional living program for adolescents with emotional and behavior disorders, and she also worked in the partial hospitalization program at Chicago's Children's Memorial Hospital. Lindsey joined KCCAT in 2009 when completing her clinical internship, then remained on professional staff and completed additional formally-supervised hours for obtaining independent-level licensure as a Licensed Clinical Psychotherapist. She provides treatment services for all ages, with a particular interest in working with youth and families, and also serves as KCCAT's Coordinator of School District Presentation Services and Outreach.
Ryan Hale-Gleason, BBA
Office Administrator and Clinic Coordinator
Mr. Hale-Gleason is the Office Administrator and Clinic Coordinator at KCCAT, and responsible for billing and patient inquiries as well as day-to-day center operations. He also serves as Information Technology Manager. He has a background in customer service, accounting, and technology, and holds a Bachelor of Business Administration degree from Baker University, with a concentration on health care administration.
Katie Gould, BA
Administrative Assistant
Katie joined KCCAT in 2014 and assists in day-to-day administrative and research tasks. She received her Bachelor of Arts degree in Psychology from the University of Missouri-Kansas City in 2015 and is currently gaining experience in the field before pursuing her masters.
Practicum Students
Jennifer Blossom, MS
Jen is an advanced graduate student in the Clinical Child Psychology Program at the University of Kansas, and current practicum student at KCCAT. She earned her BA from Dickinson College where she double majored in Psychology and History. Prior to coming to KU, Jen earned her MS in Clinical Psychology from Loyola University Maryland. Jen's clinical experience includes assessing and treating youth with a variety of presenting concerns, with previous and concurrent placements that include the KU Child and Family Services Clinic and Children's Mercy Hospital. Jen's research interests include developmental trajectories of internalizing disorders in children and adolescents, with a particular emphasis on the bidirectional and temporal associations among parent/family, peer and child characteristics (cognitive biases/emotion regulation).
Frances Bozsik, MS
Frances is a third-year graduate student in the Clinical Health Psychology Doctoral Program at the University of Missouri-Kansas City (UMKC) and a current practicum student at KCCAT. Prior to beginning the doctoral program at UMKC, she earned her MS in Clinical Psychology from Missouri State University and her BA at Kent State University in Kent, OH. Frances has received clinical training in health psychology interventions through UMKC and has experience working at Kansas City CARE Clinic. Further, she has experience conducting comprehensive psychological assessments for both adults and children through the Learning Diagnostic Clinic at Missouri State. Her research interests include the prevention and treatment of maladaptive eating behavior, social deficits associated with the development of eating disorders, and sociocultural factors affecting body image. Frances has an interest in treating obesity and eating disorders as well as anxiety.
Andy Wiese, BA
Andy is a third-year graduate student in the Clinical Health Psychology Doctoral Program at the University of Missouri- Kansas City, and current practicum student at KCCAT. Andy completed his BA in psychology from Michigan State University in East Lansing, MI in 2013. Andy has previously worked at the Kansas City CARE Clinic, where I provided assessments and interventions for uninsured adults seeking mental health treatment. His research interests included addressing clinical questions with cognitive and psychophysiologic measures, with a particular interest in using event-related brain potentials (ERPs) and electromyography (EMG) to study anxiety and emotion regulatory processes.


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Soccer savings
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Associate Professor in Molecular Cell & Developmental Biology at the University of Texas at Austin, John Wallingford, makes his living using cutting-edge microscopic techniques to watch developmental events unfold in real time. Wallingford and his team study morphogenesis—the process by which embryos change shape as they develop from a fertilized egg to a multicellular organism with distinct tissues and organs. In this slideshow, watch some of Wallingford's stunning images that capture the early development of the frogs he studies.
The emergence of blood abnormalities, an adult ability to digest milk, and changes in our physical appearance point to the continued evolution of the human race.


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We have put together a list of 30 gorgeous hairstyles for graduation as well as hairdos for prom night. You will find graduation hairstyles for both long and short hair including buns, braids, updos as well as elegant styles for those who wish to wear their hair down for this special day. These popular trends will help you find the style that best suits you.
Are you searching for chic hairstyles for long hair? Here are some photos for your inspiration! Have a happy pinning!


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Dog Grooming, Dog Training, Dog Obedience
Sitdropstay's obedience training will empower you to have control of your dog and create the behaviour you expect from them, in all situations. We offer a simple and natural approach that both empowers you and respects your dogs dignity, while helping to maintain their calm, stable natural state of mind. You will be amazed at how quickly your dog will becomes willing to do what you ask. Let us show you how to communicate with your dog naturally and easily and achieve the relationship and behaviour you have always wanted.
We understand that most people don't expect their dog to perform fancy exercises or tricks but simply want a balanced, happy and well behaved dog who listens and fits in with their lifestyle! Regular dog obedience training rarely corrects behaviour problems and unless practiced correctly, does not address the core issue; your leadership and the energy you project to your dog. Unless you want a competition dog, most modern obedience training is ineffective, irrelevant and even counterproductive, because it focuses on teaching your dog to do what is really just tricks to get a treat or toy, often inadvertently rewarding excitable and demanding behaviour. Merely teaching your dog to perform tricks for food does not fulfill your dog, and is disempowering for both of you, whilst being harsh on your dog creates mistrust and lacks understanding. Your Sitdropstay Dog Trainer will discuss with you the options that are most suitable for your particular dog and needs and then let you decide which methods "you" would like to use.
A dog that is not stable and under effective control must have its freedom limited to keep it safe in our society. Therefore establishing leadership and control allows your dog more freedom to be a part of your life. Whilst 'positive only' and treat based training is well meaning, it is science/mental based and does not acknowledge or understand the deeper and more fulfilling communication and understanding that is possible between human and dog through energy, emotion and heart. Until as dog trainers/behaviourists we truly understand the interconnection and interplay of consciousness, mind and energy between dogs and humans, we are limited to using treats, clickers, toys or fear to teach and shape their minds to perform unnatural behaviour that we as humans want. This limits our connection to them to a mental one, and not the deeper connection we are longing for with our dogs.
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Black British Designer Debuts Collection At Mercedes-Benz New York Fashion Week
Chantell Walters is one of the fresh faces gracing the runway scene this year
As the phrase is often coined "the British are coming," it's true
Chantell Walters is one of the fresh faces gracing the runway scene this year
As the phrase is often coined "the British are coming," it's true
Ikiré Jones is best described as "Brooklyn meets West Africa"
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International Business Times, India Edition
International Business Times, India Edition
Budget 2017
Anil Kapoor, Aamir Khan, Sonam Kapoor and others at "24: season 2" press meet
June 9, 2016 12:56
of 5
The action-packed trailer of '24: Season 2' starring actor-producer Anil Kapoor was unveiled here on Wednesday in the presence of his star daughter Sonam Kapoor and superstar Aamir Khan.
Credit: Varinder Chawla
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Manager post-Rams.
James Chester goal the difference.
Derby defender's pre-match views.
Early Bird window now available.
Steve Bruce talks to the press ahead of Villa's home clash with Derby.
Steve Bruce's men defeated on Tyneside.
Defeat for Steve Bruce's men at St James's Park.
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*The extracts on this page are taken from various newspapers and media outlets. They do not necessarily reflect the views of Aston Villa.
Birmingham Mail: Paul Merson has backed Villa's decision to keep faith with Paul Lambert - and welcomed the manager's policy shift to target experienced players this month. But Merson admits he does fear Villa could be dragged into another relegation scrap if they do not start to keep the ball better in games.
Birmingham Mail: Norwich boss Chris Hughton has refused to be drawn on whether Villa target Wes Hoolahan wants to quit Carrow Road to link up with Paul Lambert.
Daily Star: Norwich and Aston Villa are set to meet next week to hammer out a deal for unsettled Republic of Ireland midfielder Wes Hoolahan. Villa boss Paul Lambert has made the 31-year-old one of his top targets in this window.
The Sun: Wes Hoolahan's future will be sorted at Jed Steer's tribunal. Steer's former club Norwich and Aston Villa meet next week to decide a compensation fee for the keeper, 21. And they will also hammer out a deal for midfielder Hoolahan, 31.
Mirror: Norwich and Aston Villa are set to get together to thrash out the future of unsettled Republic of Ireland midfielder Wes Hoolahan. The two teams meet over a transfer tribunal table next week to decide a compensation fee for England Under-19 goalkeeper Jed Steer.
Daily Telegraph: Stephen Ireland is set to join Stoke City on a free transfer after an impressive spell on loan, bringing to an end his turbulent spell at Aston Villa.
Goal.com: Chris Hughton has not denied Wes Hoolahan has requested a transfer but the Norwich City boss wants the midfielder to stay at Carrow Road. Aston Villa manager Paul Lambert is reported to be eager to sign the Republic of Ireland international, who he worked with during his time at Norwich.
*The extracts on this page are taken from various newspapers and media outlets. They do not necessarily reflect the views of Aston Villa.
Tom "Pongo" Waring scores on debut at Sunderland. Villa won 3-2


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Posted: Friday, December 16, 2016 6:50 AM
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Australian Kiteboarding and Stand Up Paddle
Paddle, Stand Up Paddle, Sup Hire
STand Up Paddle is a fairly easy sport made even easier with a single 1 hour lesson showcasing the techniques required to make you a better paddleboarder.We also offer Stand Up Paddle Fitness Classes of a morning to individuals and groups of people looking to burn off some excess weight and tone up whilst having a ball at a relaxing and fun water sport that is easy enough for your grandparents to do, but at the same time is being undertaken by pro footballers, and top triathletes.Join us to find out how much fun a workout can be. You'll be having such a great time and will be so focused on paddling around the waters that you won't even know you're being worked. We do beginners and more advanced classes depending on your needs.Want to tone up and have fun? Call us and ask for more details
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Australian Kiteboarding and Stand Up Paddle is here to help you make the right decision on the board and paddle that will see you into the sport on the right gear, we guarantee you'll be stoked on our products and service.
Australian Kiteboarding and Stand Up Paddle, is Perth's fastest growing Kite and board retailer accomplished by having the most experience, the best products and the understanding that customer service is at the heart of everything we do.
Australian Kiteboarding and Stand Up Paddle has more than 10 years in the sport and is the best place to call on for information about lessons and bookings for learning the sport of Kitesurfing/Kiteboarding
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The Sausage Maker Stainless Sausage Stuffer Set of 3
The Sausage Maker 5lb. Stainless Sausage Stuffer Set of 3
Set of 3 Stainless Stuffing Tubes for 5 Lb. Sausage Stainless Stuffers.
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Name The Sausage Maker 5lb. Stainless Sausage Stuffer Set of 3 Tubes Brands The Sausage Maker (TSM) Type Meat-Stuffing Tubes Material Stainless Steel Color Silver Manufacturer's Warranty 90 Day Limited Manufacturer Warranty Electric or Non Electric Non Electric Weight (in Lbs) 1


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Janis Joplin Biography (Wikipedia)
Janis Lyn Joplin (January 19, 1943 – October 4, 1970) was an influential American singer of the 1960s; her raw, powerful and uninhibited singing style, combined with her turbulent and emotional lifestyle, made her one of the biggest female stars in her lifetime. She died of an accidental drug overdose in 1970, aged 27, after releasing three albums. A fourth album, Pearl, was released a little more than three months after her death, reaching number 1 on the charts.
Joplin rose to fame in 1967 during an appearance at Monterey Pop Festival, as the lead singer of the then little-known San Francisco psychedelic rock band Big Brother and the Holding Company. After releasing two albums with the band, she left Big Brother to continue as a solo artist with her own backing groups, first the Kozmic Blues Band and then the Full Tilt Boogie Band. She appeared at the Woodstock festival and the Festival Express train tour. Five singles by Joplin went into the Billboard Top 100, including "Me and Bobby McGee", which reached number 1 in March 1971. Her most popular songs include: "Piece of My Heart"; "Cry Baby"; "Down on Me"; "Ball 'n' Chain"; "Summertime"; and "Mercedes Benz", the final song she recorded.
Janis Joplin Tracks
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Me And Bobby McGee
Take A Little Piece Of My Heart
Piece Of My Heart
Kozmic Blues
Mercedes Benz
Summertime (Live At Woodstock)
Cry Baby
Move Over
Summertime (Porgy and Bess)
A Woman Left Lonely
A Woman Left Lonely
Me And Bobby Mcgee
Little Girl Blue
What Good Can Drinkin' Do (Live)
Trust Me
Half Moon
Tell Mama (Live)
Latest Janis Joplin News
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