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In skeletal muscle, the dystrophin-glycoprotein complex is located at the sarcolemma and is composed of peripheral and integral membrane proteins. As a whole, this complex links the extracellular matrix to the intracellular actin cytoskeleton and provides structural stability to the sarcolemma during muscle contraction. Duchenne muscular dystrophy, the most common form of dystrophy, is caused by mutations in the dystrophin gene that result in loss of dystrophin protein and the entire dystrophin-glycoprotein complex. My research group has pioneered several key discoveries related to the function of sarcospan, an integral component of the dystrophin-glycoprotein complex. We have shown that sarcospan plays an important role in mediating protein interactions within this complex. Sarcospan affects communication between the dystrophin-glycoprotein complex and the extracellular matrix. Importantly, we demonstrate that mild sarcospan over-expression in mdx mice, which possess a mutation in the murine dystrophin gene, rescues muscular dystrophy by stabilizing expression of a complex of proteins that is functionally analogous to the dystrophin-glycoprotein complex. My research group has developed the use of secondary genes, such as SSPN and Akt, as a strategy to ameliorate dystrophic muscle. Such approaches are advantages in that they have the potential to target all DMD cases, regardless of the specific dystrophin mutation. The current 3R01 proposal builds on discoveries made during the first and second funding period by interrogating specific mechanisms by which SSPN ameliorates disease in dystrophin-deficient mdx mice. We will test the efficacy of SSPN in human-derived DMD muscle cells and determine the minimal domains of SSPN that are therapeutic. Our studies will reveal a chaperone function for SSPN in determining the cell surface expression of adhesion complexes (DGC, UGC, and ?7?1 integrin) that are known to ameliorate mdx disease. We hypothesize that SSPN may function as a 'single-client'chaperone to regulate cell surface localization of adhesion complexes in muscle. The outcomes of the proposal will change our understanding of DMD pathogenesis and provide necessary insight for development of SSPN- based therapy. We will generate animal models that will be valuable for many future projects in the field. Furthermore, we expect that our results will illuminate molecular pathways that could counter a broad range of muscle wasting disorders due to loss of extracellular matrix contact.
Our proposal addresses questions related to how disruption of the dystrophin-glycoprotein complex causes Duchenne muscular dystrophy. During our previous funding period, we discovered that sarcospan, an integral component of the dystrophin-glycoprotein complex, is able to ameliorate dystrophin-deficient muscular dystrophy in mice. We will investigate molecular mechanisms and test the efficacy of sarcospan in patient cells.
|Marshall, Jamie L; Kwok, Yukwah; McMorran, Brian J et al. (2013) The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. FEBS J 280:4210-29
|Kim, Michelle H; Kay, Danielle I; Rudra, Renuka T et al. (2011) Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Hum Mol Genet 20:1324-38
|Peter, Angela K; Ko, Christopher Y; Kim, Michelle H et al. (2009) Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet 18:318-27
|Peter, Angela K; Marshall, Jamie L; Crosbie, Rachelle H (2008) Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex. J Cell Biol 183:419-27
|Peter, Angela K; Miller, Gaynor; Crosbie, Rachelle H (2007) Disrupted mechanical stability of the dystrophin-glycoprotein complex causes severe muscular dystrophy in sarcospan transgenic mice. J Cell Sci 120:996-1008
|Miller, Gaynor; Wang, Emily L; Nassar, Karin L et al. (2007) Structural and functional analysis of the sarcoglycan-sarcospan subcomplex. Exp Cell Res 313:639-51
|Miller, Gaynor; Peter, Angela K; Espinoza, Erica et al. (2006) Over-expression of Microspan, a novel component of the sarcoplasmic reticulum, causes severe muscle pathology with triad abnormalities. J Muscle Res Cell Motil 27:545-58
|Peter, Angela K; Crosbie, Rachelle H (2006) Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway. Exp Cell Res 312:2580-91
|Yi, Christopher E; Bekker, Janine M; Miller, Gaynor et al. (2003) Specific and potent RNA interference in terminally differentiated myotubes. J Biol Chem 278:934-9


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Tools and tips to bridge and enhance online/offline live events
This post by Lisa Harris, Nicole Beale and Graeme Earl reports on the findings of our Social Media in Live Events (SMiLE) action research project.
The project is looking at real and virtual communities interacting around a 'live' conference.
Our focus is to show the learning points from this experience that can be applied improve the effectiveness of future events
Research methodology
Before, during and after the event we monitored a range of social media tools to track how the tools were used by real and virtual delegates. We expected the tools to be used for information recording and sharing, network building and profile raising.
During the event we carried out interviews with conference participants about their experiences and interactions via Twitter, Storify, Flickr, Vimeo, LinkedIn, Facebook, QR codes and Corkboard. We also collected delegate feedback after the event.
You can read more about the data we collected and our initial analysis of it on the LSE Impact Blog.
Countries of the world that the vimeo videos from the CAA2012 have been viewed from.#caasoton #caaworldtakeover flic.kr/p/bGJoj2
— CAA2012 Southampton (@caasoton) March 28, 2012
Student social media champions demonstrated event best practice in real time
The use of social media champions to demonstrate best practice in real time was very successful. For example, our student Digital Champions:
- Tweeted real questions raised in sessions and acted as rapporteurs - reading out online questions to the speaker.
- Shared links via Twitter and in paper abstracts - which were automatically saved into Delicious where additional commentary on the content could be added as notes straight away – this type of activity will simply not happen if left until later.
- Created Storifys focusing on specific themes or daily summaries - which were shared to allow people to read them at the event in the form of a daily email round up of activities from the previous day. After the event a single page was created on the conference website to showcase these summaries and collated contributions from blogposts, videos on Vimeo, links on Delicious and slides on Slideshare as they were published.
Have u noticed that u can scan the QR code under the posters with your smart phone to get the presenters' email address? #caasoton @caasoton
— Yun Xu (Ring) (@ringmktgx) March 28, 2012
Key tools to enhance visualisations of social media activity
We were surprised by the scale of social media use during the conference; our archive of the #caasoton hashtag contains more than 13,000 tweets.
We are now exploring ways to add value to this archive through analysis and visualisation tools. We weren't prepared for the urgent need for us to provide effective summarisation and visualisation in real-time, or at least soon after.
Even experienced social media users almost certainly missed out on the chance to participate in many relevant discussions because they were unaware of them in real time. Whilst we saw delegates pick up topics after the conference, the practical issues of moving on and the swift disappearance of tweets from searches mean opportunities for follow up are inevitably limited.
In terms of visualisations of social media activity, we have identified some core tools that could have been set-up for use prior to the conference. For example;
- Semantically enrich tweets via creating automatic links - the WP SIMILE timeline, or tools to semantically enrich tweets by creating automatic links to locations mentioned in tweets and between related themes.
- Produce more printed visualisations - as the conference progresses, just as we produced summary videos on each day.
- Link tweets with live streaming or broadcast video from the conference - rather than projecting what, at other conferences, have been distracting and, at times, inflammatory hashtag search twitterwalls alongside presentations, in the future we plan to use tools like SnappyTV's vtweet feature - to link tweets with live streaming or broadcast video from the conference, and to edit tweets manually and semi-automatically into feeds tailored to particular sessions and topics. This way the remote user gets a social tv mashup, whilst the live audience can choose to follow a curated feed, and the presenter concentrates on talking and can respond to the twitter rapporteur at the end.
Actively encourage social media beginners to participate
Post-event feedback revealed delegates who were inexperienced social media users wanted more support during the event. So, we have incorporated a 'help desk' to get people started with twitter at subsequent events, to stop delegates feeling excluded.
It is also important to give a 'voice' to people who are not online, to prevent dominant conversations on twitter erroneously being claimed as representative of the views of all conference delegates.
Similarly, the dominant conversations on twitter could be skewed by diverse factors such as:
- The ease of summation of a given idea vs. the complexity of synthesising complex arguments
- The presentation style of research topics, perhaps by the use of 'tweet sized bites' of take home messages embedded in PowerPoints
During the event we handed out flyers to delegates with advice on structuring tweets to ensure tweeters could easily associate tweets with specific conference events and themes.
Learning points for effective integration of real and virtual event experiences
Here are some of the key learning points to help to create a bridge between real and virtual event experiences:
- During the course of the event we tried to support online events with offline events; for instance, by asking delegates to share memories of previous conferences using post-its on a long paper timeline, a gigapixel version of the timeline, and also a digital alternative of the same activity using Corkboard.
- Providing room booking facilities for people who 'meet' online while at the event to get together in a quiet space would also be useful. Some did arrange to meet up in advance of the conference by sharing their personalised event timetable.
Just noticed #caasoton delegates are sharing their schedules's URLs with each other to plan meetups at the conference. You can do the same!
— CAA2012 Southampton (@caasoton) March 22, 2012
- We could have made better use of 'real' notices rather than relying on twitter notifications. For example, people could be encouraged to leave contributions to the 'theme of the day' on a sticky board as well as online.
- We decided not to use smartphone accessible QR or similar badges with links to people's profiles at the event because this requires profile information to be collected as part of the conference registration process.
- We encouraged conversations to build bridges between the social media and real world; for example, by creating maps showing where people had come from, and where tweets happened. The publication and tweeting of printed posters as pdfs before the conference also worked well - these were subsequently linked in real time to related conversations taking place on Twitter.
If you want something to read on the train/ coach/ plane why not start looking at the #caasoton posters: bit.ly/H7k5YW
— CAA2012 Southampton (@caasoton) March 26, 2012
- It is important to be really clear about what content is being captured and what will be done with it after the event. One delegate noted she was aware video was being recorded, and had agreed to it, but hadn't realised before the start that this could potentially capture her personal conversations. Capturing and sharing content was further complicated by our use of tools like Flickr to collect and annotate user-submitted photographs from previous events, dating back as far as the early 1990s.
Possible solutions to this situation include:
- Physically 'badging' people who do not want to be filmed, for the benefit of video editors
- 'Red flagging' tweets that their author does not want to be archived.
Create continuity between present and future events
We expect the materials we have created and archived will play a role in determining the structure and focus of next year's event; as will ongoing members of the event organisation team.
For example;
- Follow-up persistent and emerging themes - emerging themes that generated significant debate could be allocated a specific session of their own and, by comparing content between the two events, it should be clear in which topic areas the debate has moved on and whether specific agreed actions have been delivered.
- Engage virtual event attendees - during the conference, there were various individuals who engaged with the event through social media who were not attending; indeed some were newly introduced to the community via those channels. This highlit the potential for the methods outlined above, not only for supporting the event's community as it currently stands, but also for encouraging new membership, and broadening our reach beyond the confines of a single venue and time-frame.
About the authors
Lisa Harris is a senior lecturer at the University of Southampton focusing on digital marketing. She chairs the Digital Economy University Strategic Research Group with Graeme Earl. More details at: http://lisaharrismarketing.com
LinkedIn: http://www.linkedin.com/in/lisajaneharris
Twitter: @lisaharris
Nicole Beale is a PhD student at the Archaeological Computing Research Group, University of Southampton. She is researching into the cultural heritage sector can engage with the Web as social machine. She blogs at http://theculturalheritageweb.wordpress.com/
LinkedIn: http://uk.linkedin.com/in/nicolebeale
Graeme Earl is a senior lecturer at the University of Southampton focusing on digital humanities research. He chairs the Digital Economy University Strategic Research Group with Lisa Harris. More details at: http://digitalhumanities.soton.ac.uk/people/graeme-earl/
Twitter: @graemeearl
With thanks to Buzz Radar for use of the conference image.

subset: commoncrawl


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Lol @CF to expose me so badly embarrassing it is! I feel like a criminal now. Well, but can you really blame us?
I love the faucet, its simplicity, claim interval and the theme colour. I wouldn't want it any other way.
chikitta wrote:I have signed up for it and I think I like the idea. But I have a question whatever we earn is added to the forum coins that we have? Or what.
kaka135 wrote:I have read about bitcoin faucet online, but I always don't understand how it works and I never go and check it out. Since it's ForumCoin faucet, I am going to give it a try. I'll explore it slowly.... it sounds fun!
Thanks for creating another way to earn FC for us!
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Free Download Quern Undying Thoughts for PC – Discover the truth about Quern's past, unfold the mysteries of it's present, and be the explorer who shapes its future. Quern introduces reusable puzzle mechanics to the classic genre, making the player think about the game as a whole, and not just as a series of individual […]
Archive for November, 2016
Quern Undying Thoughts
November 30th, 2016 rodax
Darksiders Warmastered Edition
November 30th, 2016 rodax
Free Download Darksiders Warmastered Edition PC Full Version – Deceived by the forces of evil into prematurely bringing about the end of the world, War – the first Horseman of the Apocalypse – stands accused of breaking the sacred law by inciting a war between Heaven and Hell. In the slaughter that ensued, the demonic […]


text: Pioneer VSX 919 AH….AV amplifier Welcome to Rob's Satellite TV! › Forums › General Forums › Technical Forum for NON satellite questions › Pioneer VSX 919 AH….AV amplifier This topic contains 25 replies, has 4 voices, and was last updated by Steve …… 2 years, 2 months ago. Viewing 26 post (of 26 total) ← 1 2 Author Posts 18/12/2014 at 5:53 pm #11395 Steve ……Member Your right Twol………….this is all disappointing and surprising ……… …..after looking around the Hifi shops today…….Seems RCA and optical is being phased out or reduced  from all AV amps….. 🙁 …….So I will stick with my "old fashioned" Pioneer 919AV setup for now………. Personally I'm quite happy with the RCA  connection audio sound quality and RGB Scart SD picture quality on the Pioneer tv………….( a Quality RGB Scart connection  is a must ….when using my super crappy Amstrad Sky HD box …as it is a truly awful SD channel upscaler via HDMI )…. (probably designed that way to make the Sky HD channels look better)…?….. Never even heard of a "Leak 2000" hifi…….Tho…….. Author Posts Viewing 26 post (of 26 total) ← 1 2 You must be logged in to reply to this topic.


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Need-Based Scholarships
Need-Based scholarships are awarded to admitted students who qualify based on financial need. This scholarship will be offered through the USU Financial Aid Office in varying amounts based on the following information and deadlines:
All applicants wishing to be considered must also complete a Free Application for Federal Student Aid (FAFSA) at fafsa.ed.gov. For more information, call the Office of Admissions at 1-800-488-8108. 2017-18 FAFSA applications will be available online starting October 1, 2016.
To be considered for need-based scholarships, applicants must:
- Complete online application to USU for fall 2017 (including application fee)
- Be a U.S. Citizen or have a Permanent Resident Status
- Be eligible for federal Pell grants
- Have intent to graduate from Utah State University
- Be a new first-time student to Utah State University. Returning students and 2nd bachelor students do not qualify for need-based or academic scholarships. Concurrent enrollment students are still eligible for scholarships.
- The Needs-Based Scholarship is not deferrable. Students planning to defer admission to a later semester must apply for the Needs-Based Scholarship in the year they are planning to attend.
Recipients of the Need-Based scholarship will be notified by Financial Aid Office at the end of March 2017. Need-Based scholarships are limited and will only be awarded on a first come, first served basis to students who apply and qualify by the advertised deadlines. Please apply as early as possible for consideration.
Scholarship and FAFSA Deadline
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text: We have lunch or dinner with my mum, brother and sister. Our family is not really close, so we don't have 20+ people attending. We all do our own thing. Dp family all live in Vic so we won't be celebrating with them unfortunately. It's also dp birthday on Christmas day so if we have Christmas lunch, we would have birthday dinner and so on Pretty much one half of the day is Christmas (apart from morning when kids wake up and open presents) and the other half is birthday!


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iPhone apps
Tap Wrestle
Tap Wrestle brings arm wrestling to your iPhone or iPod Touch.The faster you tap the harder you push your virtual arm. You will find the limits of your real arm too! :-)Captured video adds to the look and realism of this App.Single and multi player….. Read more
What's New in Version 1.1
fixed bug where tap indicator could be missing if finger dragged off screen.
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Hotfrog Canada provides information regarding OM Space Studio in Coquitlam BC. OM Space Studio is located at 608 Forbes Ave, Coquitlam BC and provides personal care services. Contact them on (604) 710-1566.
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Our goal is to understand the regulation of ErbB signaling in endometrial and breast cancers, diseases where amplification of ErbB genes (EGFR, ErbB2, ErbB3) is associated with poor outcome. The composition of the UNM team is unique, with expertise in signal transduction, high resolution microscopy, mathematical modeling and animal models, as well as leadership roles in GOG clinical trials. This multiscale project begins with nanoscale evaluation of receptor topography and behavior, measured with innovative electron microscopy, live cell imaging and flow cytometry technologies. Innovations include development of monovalent quantum dot probes for single particle tracking of resting and ligand-bound receptors. These measurements provide quantitative information for mathematical analysis using a mixed stochastic/continumum approach that is aimed at evaluating the contributions of membrane spatial organization to ErbB signaling. The stochastic platform simulates diffusion, clustering and internalization of receptors and signaling molecules using Monte Carlo and agent-based methods. By applying state-of-the-art experimental and modeling approaches, we will specifically consider the impact of combinatorial complexity upon signal propagation. We will also address receptor mutations, receptor conformational state, and the use of clinically-relevant inhibitors. For example, the group discovered a new ErbB3 mutation in the previous funding cycle. We intend to screen for this mutation, as well as evaluate ErbB3 expression levels, in over 200 human breast and endometrial cancers. Critical tools include cell lines bearing mutant receptors or expressing specific combinations of ErbB receptors as VFP-fusion proteins. By combining our unique and comprehensive data sets with stochastic modeling, we have already challenged current estimations of homo- and hetero-dimerization between Erb family members. We will continue this exciting work to fully explore the spatial and temporal aspects of ErbB signaling at the cellular level. By year 3 of the project, the experimentalists will complement their studies at the cell and molecular scales with xenograft models in mice. This work will permit evaluation of oncogenic signaling in vivo and move the project from nanometer and micron length scales to millimeter and centimeter length scales. Time scales also move from millisecond and minutes up to hours or days. Data from the mouse model will provide critical parameters for a new a cell-based solid tumor model. The tumor model will then be used to predict rates of tumor growth, angiogenesis and drug responsiveness in vivo. Cell behavior in the tumor model will be governed by outcomes from the stochastic model, bridging the two mathematical modeling platforms that consider markedly different length and time scales. Public Health Relevance. This project targets two women's cancer, breast and endometrium, and the ErbB family of receptors. ErbB signals are powerful inducers of gene transcription involved in tumor growth and survival, providing a rationale for use of drugs that inhibits ErbB pathways in the treatment of cancer. The mixed response of individual patients indicates better understanding is needed to predict initial patient response and the likely characteristics of recurrent tumors. Hormone-responsive cancers, such breast, ovarian and prostate, develop in a multistep process that starts from a local benign hyperplasia and ends with an invasive tumor able to metastasize to other organs. Tumors are genetically heterogenous by the time their presence is discovered, a property that translates to complexity in selecting the proper therapeutics for specific patients. Both our biology and modeling are ultimately aimed at understanding the heterogeneity of ErbB expression in individual tumors and applying that knowledge for personalized, predictive tumor therapy.
|Davies, Suzy; Holmes, Anna; Lomo, Lesley et al. (2014) High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Int J Gynecol Pathol 33:402-10
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|Pryor, Meghan McCabe; Low-Nam, Shalini T; Halasz, Adam M et al. (2013) Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modeling. Biophys J 105:1533-43
|Low-Nam, Shalini T; Lidke, Keith A; Cutler, Patrick J et al. (2011) ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding. Nat Struct Mol Biol 18:1244-9
|Hsieh, Ming-yu; Yang, Shujie; Raymond-Stinz, Mary Ann et al. (2010) Spatio-temporal modeling of signaling protein recruitment to EGFR. BMC Syst Biol 4:57
|Hsieh, M-Y; Yang, S; Raymond-Stinz, M A et al. (2008) Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation. IET Syst Biol 2:256-72
|Burns, Alan R; Oliver, Janet M; Pfeiffer, Janet R et al. (2008) Visualizing clathrin-mediated IgE receptor internalization by electron and atomic force microscopy. Methods Mol Biol 440:235-45
|Zhang, Jun; Steinberg, Stanly L; Wilson, Bridget S et al. (2008) Markov random field modeling of the spatial distribution of proteins on cell membranes. Bull Math Biol 70:297-321
|Wilson, Bridget S; Pfeiffer, Janet R; Raymond-Stintz, Mary Ann et al. (2007) Exploring membrane domains using native membrane sheets and transmission electron microscopy. Methods Mol Biol 398:245-61
|Yang, Shujie; Raymond-Stintz, Mary Ann; Ying, Wenxia et al. (2007) Mapping ErbB receptors on breast cancer cell membranes during signal transduction. J Cell Sci 120:2763-73


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Your photo book, Understanding Exposure, has sold 1 million + copies. How was the promotional experience?
What was your marketing experience like for your photo book?
Anonymous-Surprisingly this book has sold more than a million copies with very little promotion, yet with the best promotion of all, promotion that money can't buy and that promotion is called 'word of mouth'! I really cannot explain it, other then that.Bryan


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CLOSED: Organix
111 Moo 1 Ban Tai, Koh Phangan, Thailand, 84280
Organic and superfoods store in Ban Tai, Koh Phangan. Stocks food supplements like spirulina, chlorella, cissus, moringa, and tumeric. Also offers fresh fruit and vegetable juices made in a slow juicer. Reported closed to HappyCow.
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Love Spell Wicca in Los Angeles, CA
Welcome! My name is Phelan, I am a psychic, witch practitioner and root worker located in Atlanta, GA. I specialize in performing white witchcraft rituals customized to all my client's needs. You may call me at 678-918-3333 or create an account if you have questions about love binding spells, binding spells for protection, protection/shielding spells or white magic binding spells or if you are interested in Love Spell Wicca. Even though I am physically located in Atlanta I can bring positive and magical change to you in Los Angeles, CA, magic knows no boundaries!
I can also assist you with love binding spells, binding spells for protection, protection/shielding spells or white magic binding spells in Los Angeles, CA or you may call me today at 678-918-3333 to discuss your situation if you prefer.
Spirit Guides speak to me through the means of clairaudience, which is my ability to hear clearly on a psychic level, through the art of clairaudience much can be heard to change the path of a esoteric client, meet with me today to learn how you can change your path.
Please feel free to give me a call at 678-918-3333 Mon-Fri from 1-9 pm EST or create an account to discuss your situation in a private manner, again it doesn't matter if you live in Los Angeles, CA or in Greensboro, NC, I work with people from all over the world, magic has no boundaries; therefore, I can be of assistance to you regardless of my location and yours .
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As a critic (lol): Very deep and insightful. I wouldn't say total néw info..but I think you have awesome clarity on what is, but more importantly, you are ready to move forward. .
As myself: I read this three times and it was beautiful. Also copied the link to read much later in the future. Lol. Thanks for sharing.


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John Deere Birthday Invitations
Do you need ideas for your Birthday invitation? Today I'd like to share the collections of john deere birthday invitations, all of them are definitely worth your attention. John deere birthday invitations will inspire you with 19 awesome ideas for your Birthday invitation with a various styles and trends.
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WordWise Gameplay 1 iOS / Android
By: Polyclef Software
Genre: Board
Video Tips
Let's play WordWise! This is part 1 of my walkthrough for the iOS and Android game WordWise.
Still need help to finish WordWise gameplay?
I will update this post with more tips and tricks, so please bookmark this page and keep on checking in!
If you have any questions, feel free to ask for extra help in the comments section.
Hit like if this helped you!
Visit WordWise walkthrough page for level videos, tutorials, cheats and more.


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In Social Media, Everyone Has 'The Right' To Be Offended
You can't please everyone all of the time. This is especially true in social media, where simple mistakes can turn into international media incidents.
You can't please everyone all of the time. This is especially true in social media, where simple mistakes can turn into international media incidents.
Google has actually made it pretty darn simple, easy, and cheap to implement structured data on your site if you have any kind of event information there.
Social networks, review sites, deal sites, and mobile applications can be some of your best strengths if you utilize them to your advantage.
How social media and mobile are reshaping information distribution.
Small businesses can do social media; it's just about being savvy enough to incorporate some of your strategies into procedures that already exist.
Social media has developed into an effective component of digital strategy, but measuring its performance is still a challenge. How will analytics affect social media in 2017?
There are so many ways in which email continues to develop and progress, but in one way email still lives in the last decade.
A great customer experience has moved from 'nice to have' to 'can't do without'. Your users expect be engaged from the moment they land on your site, held in rapture at each stage of the conversion funnel. Is your CMS the key to delivering?
27-year-old Swede Felix Kjellberg, who goes by the name PewDiePie on YouTube, has found himself at the center of a firestorm.


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Shivdhara Hotel and Residency
Call us 1800-300-2400-1 (Toll Free) and Get additional Discount upto 50% for this Hotel.
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About Shivdhara Hotel and Residency
Shivdhara Hotel and Residency is situated at a distance of 3 km from Rajkot Junction (Railway Station). This accommodation in Rajkot offers 24-hour front desk facility for its guests. This hotel in Rajkot maintains 2 floors and 22 spacious rooms. The rooms are equipped with amenities like adjustable windows, telephone, air-conditioner, wardrobe, seating area and an attached bathroom with hot and cold water facility.
No of floors: 2 | No of rooms: 22
Checkin Time: 1000 pm
Checkout Time: 900 pm
Hotel Amenities
- Wardrobe/Closet
- 24 Hour Power Supply
- Room Service
- Parking
- Luggage Storage
- 24-Hour Front Desk
- H/C Running Water
- Bottled/drinking Water
- Complimentary Toiletries


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Pet Setting & Drop Ins in Charlottesville High, Charlottesville, VA
Book a pet sitter to stop by your home a few times a day to feed and play with your dog.
Animal Aficionado & College Student
Main-Starr Hill, Charlottesville , VA, 22309
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Pawfessional attention for your pup
Downtown, Charlottesville , VA, 22902
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About: I love all dogs, big or small, furry or fine. I will give them all the love and attention they require and take them on the best adventures. I hav... (more)
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Work-from-home, reliable dog lover
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I just really love dogs
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Hire freelancer for Data Mining in Detroit, MI
Easily connect with local Data Mining freelancers in Detroit, MI. Browse through our database of thousands of talented professionals in Data Mining ready to work today. Once you selected your ideal candidate for Detroit, MI in Data Mining, contact directly and negotiate your own terms. Hire Data Mining professionals in Detroit, MI.
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Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
Roanoke, VA - Faulconer Construction will begin construction today on the new Amtrak Platform on Norfolk Avenue. The work is expected to take 300 days to complete. During the project, travel on Norfolk Avenue will be reduced to one-way eastbound traffic, between the Martin Luther King Bridge and Jefferson Street. Railside Avenue, behind Warehouse Row, will have restrictions to parking within 10 feet of the temporary fenceline to accommodate one-way eastbound thru-traffic, only. For more information, contact Civil Engineer Pricilla Cygielnik at 853-2035.


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Cue (20-07-2013)
Orchids.... well, it seems like you don't really have anu "issues", so you seem like you're very close. I'm sure it's going to work on the next go for you.
AFM.... Our 4 little embies are still alive and kicking at day 3. Two are perfectly on track at 8 cells, one is OK at 6 cells, and one is being slow at 5 cells. All 4 were graded A, meaning that there's little fragmentation, so that's good news. We've had a couple get to day 3 before, but it's getting past to day 5 that is the problem, but the scientist said that seems to be many embryos problems. Anyhow, it's looking really good, so transfer is set for Monday morning. I think it will be a long 2 day wait til then :-))
Sorry you are feeling so down. I also didn't hear from my FS just the nurses in the clinic after my BFN so just asked them what the next step was and they said I could do a back to back FET.
I also got the 'talk' from the FS before i started, about the chances of a live birth at my age (44) which he said was practically nil and if it wasn't for my fiancé saying he was still happy to give it a try, I was almost ready to walk out without starting.
I think they are just brutally honest and I guess they feel they have to be because there are no guarantees. Still doesn't help though.
Big hugs to you. X
Cue (20-07-2013),MGC Bertie (20-07-2013)
So they've put me on Puregon at 250 units a day .
I don't know if thats a lot or a little? I dont have much experience with this.
Im wondering who creates the threads and does anyone know if there will be a july august thread? I think I may have to jump into that one...
Wishnhope.... good luck, my transfer buddy for Monday :-)) 11 fertilised is fantastic. I guess you won't get an update tomorrow, considering it's Sunday, will you? Have they said your OHSS is mild enough to proceed with the transfer then? That's great news. I note that our BT date is the same too, even though I am doing a 5dt. I guess just differences in clinics. That date is my first day back at work after long service leave, so I probably won't even get the chance to find out until after work, which is probably a good idea, in case it's not good, and I start crying. But then again, if it is a BFP I'll probably start crying as well!!
7liha....everyone's meds are different, so it's really hard to compare dosages with others. There's so many factors as to which protocol they put you on, which meds, which dosages - factors include age, medical issues and just difference in levels from one person to another, so I wouldn't worry about that. Your FS would have used your 1st cycle to get lots of data to go on for you.
And yes, as Wishnhope said, others have already created a "July/August" thread and an "August/September" thread, so you just need to look in this "IVF" section for them.
I dont get updates til Monday unfortunately, I might give them a call before my ET as thats not til 11:45!!
No one has mentioned the OHSS since my BT and scan on Wednesday, the embrogist and the nurse both said transfer would be Monday with no hesitation and when I called this morning for the ET time nothing was mentioned either. Either my levels went down enough not to warrant cancelling my transfer or they've compleley forgotten (and I wouldnt put it past them) Im keeping an eye on myself. No bloating, nausea or vomitting. Ive been drinking 2 + litres a day since before my EPU and taking it easy. It all pays off!
MGC Bertie (20-07-2013)
Sounds like you're all set Wish - hope Monday goes well for you! Keep fluids up after ET too as water is good for cell development
MGC Bertie (21-07-2013),Wishnhope (20-07-2013)
Orchids - I had a nurse phone me with the first bfn then the dr for the second. Chatting to the dr was so much more helpful, to debrief and find out what my options were. I felt a bit stranded when it was the nurse, as she gave me sad info then hung up! Wasn't quite sure what to do next.
Cue - glad to hear you can focus on the positives after getting sad news. Fingers crossed the next cycle is your lucky one.
MGC - yay for healthy embryos at day 3!! That is really exciting. You know the hardest part of my cycle (other than the bfn) was checking on my embryos for the first 3-5 days. Nerve wracking! Best of luck for tomorrow. I have everything crossed that you will have a sticky one on board.
Wishnhope - best of luck for your transfer too!! I really hope it goes well and the little emby (ies?) make themselves quite at home.
Appy - thanks for telling me about the pipelle scratch. I hadn't heard of it before but it sounds like it's resulted in a massive increase in success rates in trials. Will check with my dr about whether we could do it on our month before FET.
AFM - AF came today (so heavy and painful) and I feel awful, in an out of control hormonal type way. Yuck. Feeling good about taking a month off before cycle 3.
Pregnant for the first-time?
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Our Insider Programs for pregnancy first-timers will lead you step-by-step through the 14 Pregnancy Must Dos!


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Andy Holmes, the rower who twice won Olympic gold with Sir Steve Redgrave, has died after being treated for symptoms of Weil's disease.
The double Olympian died a week after being admitted to hospital. He is thought to have contracted the disease, which is typically spread by the urine of infected animals such as rats and which is a hazard for watersports athletes, after contact with river or lake water.
Tributes to Holmes, 51, were led by Redgrave, who celebrated victory with him in the coxed four at the 1984 Olympics and in the coxless pairs at the 1988 Games.


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Since 1993, ACI Asphalt professionals have been providing quality asphalt and concrete products and services to valued customers. Located in the Minneapolis and St. Paul Metro Area, ACI provides pavement solutions for all types of properties: Commercial, Industrial, Municipal, Churches, Townhomes, Condominiums and Apartments.
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Eligibility Review Consultation Multi-provider Forum 04 November 2010 Multi sector provider forum 4th Nov
Introduction What the proposal means and how it may affect you and the people who use your services. Sandy McMillan, Assistant Director (Strategy and Commissioning)
Eligibility Criteria are a set of rules that the Council have to use when they are deciding who can receive council funded adult social care services. The definition of eligibility criteria the Council uses are set by the Department of Health. gitalasset/dh_ pdf What is Eligibility?
What are Eligibility Levels? When a worker completes a Community Care Assessment, they look at what support a person needs. There are 4 levels of need and they are low, moderate, substantial and critical.
What are critical needs? The persons life could be threatened Very bad health problems They have no choice about what is around them Abuse could happen or will happen They cannot look after themselves properly They cannot go to work or school They cannot make and keep friends There is serious risk of harm to themselves and others They cannot get out in their community
What are substantial needs? They only have a small amount of choice and control about what is around them Abuse could happen or will happen They cannot carry out most routines to look after themselves Going to work or school is very difficult Making and keeping friends is hard There is some risk of harm to themselves or others They do have some ability to access their community They cannot carry out essential day to day tasks
What are moderate needs? They cannot carry out a few routines to look after themselves They can have some involvement in work and education Making and keeping friends is hard Their ability to access their community is limited
What Happens Now? At the moment the Council provides services to people who have moderate, substantial and critical levels of support needs. The Council does give advice and information to everyone, no matter what level of need they are. The Council also commissions a range of preventative services where people do not need to meet eligibility criteria
What do we want to change? The Council is looking to raise the level of need for the people they provide services to. This means that they would only be providing care services for people with substantial and critical levels of support needs.
Who would be affected by the changes? This would affect adults aged 18 years old or over who use community care services that are provided or arranged by the Council or who may need services in the future.
Helping people to be Independent The Council want to help people to be more independent and will provide some short term services to all service user groups for up to 6 weeks. The Council will also make sure advice and information and other preventative services are better and will help and support people in local communities to get other support through Personalisation.
What will happen next? When the consultation ends in December 2010 the results will then go to the County Councils Cabinet Meeting in January The Cabinet will look at the results and then make the final decision.
What would happen next? If the Council raises the level of support to substantial and critical this will happen from April This would mean that some service users will no longer be able to get the services they are getting now.
What help would people be given? The services would not stop straight away for existing service users. Service users, carers and family members would be fully involved in what is happening. They would be given lots of advice about how they can get other services and they will be given plenty of time to change over to those other services.
What alternative services are available? Keep the same home care provider and pay the agency or service provider direct, perhaps using Attendance Allowance or Disability Living Allowance. Look at different ways of meeting your needs, using facilities like leisure centres or joining a community group rather than day care. The Council can provide equipment and technological solutions to common problems, that can help people to be more independent.
Tell us what you think. The Consultation takes place from 17 th September until 10 th December You can fill out a questionnaire and return it in the envelope provided. You can fill in the questionnaire on a computer if you have one, the web address is
Helping you to participate We have a helpline number for you to contact: We can provide the questionnaire in an Easy Write format, Large Print version and in other languages.
Contact us You can write to us and let us know what you think at the following address:- Eligibility Review Consultation 2010 Room 312 Adults and Communities County Hall Glenfield Leicester LE3 8RL
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A$AP Rocky Premieres His New Song "M's" at Red Bull Music Academy
A$AP Rocky is talking about M's! Today the Harlem rapper premiered his new track "M's" during a session with Red Bull Music Academy in London. The song which features production from Mike Dean and the Honorable C.N.O.T.E. will appear on A$AP Rocky's upcoming sophomore album At.Long.Last.ASAP (A.L.L.A) that is scheduled to drop on May 26th. Check out A$AP Rocky's hot new track "M's" above.
A$AP Rocky premiered his new song "M's" off his upcoming album 'At.Long.Last.ASAP' at Red Bull Music Academy in London.


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So now the year is almost done, the last vestiges of the worst World Cup campaign by any host nation have been swept away and out of Twickenham and, you wonder, is that the end of the affair?
When Andy Farrell, Graham Rowntree and Mike Catt lost their jobs last week, that was the line in the sand, the full stop. The past is the past. A sporting catastrophe has been given a neat ending.
Hang on. Let's not move too fast.
Yes, fast Eddie Jones is here, moving on the narrative, quickly, hiring new coaches — or at least attempting


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Love it or Loathe it: Nikki Reed
We're green with envy over Nikki's impeccable sense of style! The Twilight star totally smouldered at the New York screening of Twilight Breaking Dawn Part 1. The shape of this chic maxi channels the screen sirens of old, whilst that cut-out detail and bright lime colour keeps things looking bang up-to-date. What do you make of this stand-out gown?
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Original Paper
Influence of surface misorientation of HPHT diamond substrates on crystal morphologies and threading dislocations propagation
Version of Record online: 24 JUL 2013
DOI: 10.1002/pssa.201300071
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
physica status solidi (a)
Volume 210, Issue 10, pages 1985–1990, October 2013
Additional Information
How to Cite
Naamoun, M., Tallaire, A., Achard, J., Silva, F., William, L., Doppelt, P. and Gicquel, A. (2013), Influence of surface misorientation of HPHT diamond substrates on crystal morphologies and threading dislocations propagation. Phys. Status Solidi A, 210: 1985–1990. doi: 10.1002/pssa.201300071
Publication History
- Issue online: 18 OCT 2013
- Version of Record online: 24 JUL 2013
- Manuscript Revised: 14 MAY 2013
- Manuscript Accepted: 14 MAY 2013
- Manuscript Received: 15 APR 2013
Funded by
- French ANR project CROISADD (ANR-11-ASTR-020)
- French ANR project V-LOC (ANR-2010-BLAN-0812-01)
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Without clear carbon controls from the International Maritime Organization, the shipping industry may have to adhere to multiple sets of regional regulations, according to Esben Poulsson, chairman of the International Chamber of Shipping.
The Warren, Mich.-based trucking carrier and third-party logistics provider saw net income plummet 39.2 percent year-over-year to $24.2 million as revenues slid 5 percent to $1.07 billion, according to the company's most recent financial statements.
Hyundai Heavy Industries' shareholders on Monday voted to approve the company's restructuring plans despite strong union opposition.
Registration takes less than 1 minute.
Two Floridian ports changed plans on inking deals with the Cuban government after Florida Gov. Rick Scott said he would recommend restricting state funds for ports that work with Cuba.
The Israeli container carrier told American Shipper Friday it is rejecting the rumor that it has intentions to sell its global shipping operations to instead become a regional Mediterranean carrier.
A coalition of 25 business groups has asked the Federal Maritime Commission to address fees imposed when shippers can't pick-up and return cargo, containers and chassis for reasons beyond their control.


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Notes on the first Monday of November
The passivity is driving me insane.
I should be used to this by now, but I cannot fathom how we persist with a clear lack of initiative and an aversion to responsibility.
I am trying to decide if I thrive better in a highly-competitive environment or a laxed one. I think it's the former. Stress, I can manage but inaction will be the death of me.
On a somewhat (but not really) related note, I think I hold on because it's the only thing that's constant in my life. The instability and uncertainty can be too much to deal with sometimes but I'd rather chose dysfunction than face this all alone. I hope to snap out of it one day, but for now this is the only way I can cope.
In an alternate universe, I would've considered a probable option but today I realized why it could and would hit a dead end. We don't operate in the same terms and in spite of my undeniable affinity to Y, certain forces will only tear it apart.
Literally and figuratively speaking, nothing makes sense.
Not yet, at least.


text:
Comment to those looking at my sermons: My Personal Life Mission: To cultivate and promote the Word of God in all believers. To build and promote His Kingdom, and develop mature ministering believers by mentoring, teaching, and love, as God's enable me in holy accountable and incarnational relationships.
Sermon or series that made a difference: All of them
What my spouse (really) thinks of my sermons: She loves them!
Best advice given to me about preaching: "I do not believe there are any new objections to be discovered to the truth of Christianity. Men may argue ingeniously against our faith, but what can they say in defense of their own?" (The author of our national anthem, Frances Scott Key). Therefore, "So be strong, show yourself a man, 3 and observe what the LORD your God requires: Walk in his ways, and keep his decrees and commands, his laws and requirements. . ." (1 Kings 2:2-3a)
Books that have had an impact: God's Word
I married my best friend and love being with my family. I love to study the Bible, preach, teach others how to study the Bible for themselves! I love to write commentaries and sermons. I have suffered a serious back injury and am now disabled but not out of commission. I also do some video editing as a hobby. I do not make shallow relationships and I am not a drama kind of person, although I have been known to be sarcastic and I tend to use puns a lot more then my family prefer.
If I could Preach one more time, I would say...: When you study the Bible its not long before the Bible starts studying you! "18 Open my eyes that I may see wonderful things in your law. (Psalm 119:18)
Something funny that happened while preaching: I farted
What I want on my tombstone: Leonard Cook: A Man of the Spirit, A Man of the Word, A Man of God
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