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…' social feeds with too many updates kids. Malkovich? Malkovich! The original Hodor proves that he's an artist dammit! Click for some genuinely unsettling images. Right, that's it for this week. As promised, not a Viking in site. Me and the internet are off to rustle cabbages from Farmer MacGregor's garden. I can't imagine anything going wrong. See you next week! Matt Owen is Head of Social at Econsultancy. You can follow him on Twitter , add him to your circles on Google Plus, or hook up on LinkedIn. …


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Locate a Maserati car dealer in Bay Village, OH. Get a free quote on a new or used Maserati or contact a Maserati dealership in Bay Village for financing, incentives, and Special Offers.
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A.P. Fuchs
Artist, Writer, and Editor in Winnipeg, Manitoba, Canada
A.P. Fuchs
Artist, Writer, and Editor in Winnipeg, Manitoba, Canada
I've written a lot of books and stories over the years, having begun my journey in 2000 writing comic scripts and then switching to short stories. I think it was after only one–possibly two–short stories that I decided to write a series of short stories that would all connect. That plan quickly gave birth to the prologue of my first novel, A Stranger Dead. From there things kind of snowballed on the writing front and since 2003 I've published around 30 books, sold a bunch of short stories, published poetry, articles, comics and have published over 100 books for other people.
I'm mostly known for my superhero series, The Axiom-man Saga, which began in 2006 though the character was created long before that.
Over the years I've been a writer, an editor, a publisher, a cartoonist, and come from the school of hard knocks, having had my share of victories and defeats.
Weekly newsletter goes out Saturdays. Get a free thriller e-novelette for signing up.www.tinyletter.com/apfuchs


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News and Point of View
Using intent data to uncover Martech attendees' interests
Exclusively using our intent data, YesPath has conducted an analysis to find out what topics are hot (and not) for 2016 Martech attendees. And the winners are…read more
True Influence partners with Bombora to make intent data actionable
Bombora continues on its path to bring rich B2B intent data to marketing and sales with the addition of data-driven technology company, True Influence to it network of partners and ever-growing Co-op of premier publishersread more
Whitepaper: Infusing intent data to scale your Account-Based Marketing
Mike Burton shares insights from a white paper by Lattice Engines that goes 'beyond the buzz' to outline how marketers can scale their Account-Based Marketing with predictive analytics and intent data.read more
Intent data infused SmartPersonasTM set to supercharge B2B content marketing strategy
The partnership between Cintell and Bombora is set to empower B2B marketers with critical topics of interest of target buyers. Infusing Bombora's industry-specific intent data into Cintell's SuperPersonas will mean development of more effective content marketing strategies and execution of increasingly targeted ABM campaigns.read more
B2B intent data provider Bombora posts 1500% revenue growth, profitability and roster of nearly 40 partners in first year
In its first year of operation we share our results and Erik Matlick reflects on the fundamental drivers of our success – the growth of our co-op of premium publishers, best-in-breed partners and by taking an 'everyone wins' approach.read more
Business 2 Community – Avoiding 'needle-off-the-record' moments using intent data for content marketing
Mike Burton explores how marketers can use intent data to understand what the topic of conversation is and identify the optimal times for B2B marketers to join in.read more
CMO.com – What's Next For Programmatic?
With programmatic ad spending to reach $20 billion by the end of 2016, CMO.com asked our own Erik Matlick for his take on what is in store for the year.read more
Demand Gen Report – Supercharging B2B inbound with better site personalization and analytics
Site personalization has become critically important in the B2B sphere. Mike Burton discusses how using intent data can supercharge a marketer's website into a lead machine and improve content marketing strategy.read more
CIO Review – Bombora enhances Adobe Audience Manager to empower Account Based Marketing
Bombora is excited to be innovating with Adobe and empowering B2B marketers with an unprecedented opportunity to enhance their Account Based Marketing.read more
VisiStat, Inc. Partner, Bombora, Inc., Reports a 160% Lift in Behavioral Interactions Across its Intent Network with KickFire Domain2IP API
VisiStat®, a cloud-based B2B sales automation company, is pleased to announce its partner, Bombora, has reported an increase of 160% in its ability to map behavioral interactions across its Firehose Feed and account-based marketing (ABM) products since implementing the KickFire™ API as its source for domain to IP resolution.read more
Direct Marketing News – Intent data provider, Bombora and Adobe Announce Partnership
Bombora is excited to announce it's partnership with Adobe – the first B2B intent data offering within Adobe Audience Manager.read more
Use intent data to anticipate your customers' needs
Mike Burton discusses how marketers can use intent data to gain insights about decision-makers and their spheres of influence to drive conversion.read more
Online B2B Advertising to Reap Account Based Marketing Improvements through HG Data and Bombora Partnership
Adding a new, unique dimension to B2B ad targeting the partnership between HG Data and Bombora will enhance the targeting possibilities for online Account Based Marketing (ABM).read more
Infer blog – Q&A with Bombora Co-Founder Mike Burton about intent data
There's a lot of buzz in the marketing community around 'intent data' and Mike Burton speaks to Infer to shed some light on how it works, what benefits it delivers and how Bombora makes this happen.read more
6sense and Bombora form an exclusive partnership to provide the industry's first Integrated predictive marketing platform
Bombora and 6sense partner to provide the industry's first integrated predictive marketing account and contact-based solution to operationalize account-based marketing and contact profile targeting for digital display campaigns.read more
Oracle Blog – The evolution of B2B intent data
Erik Matlick discusses why the next step in the evolution of B2B data is intent data at scale and how it can empower marketers to create efficiencies and boost engagement throughout the sales funnel.read more
Marketing ID – Podcast: Aligning marketing and sales under one data source
Marketing ID sat down with Erik Matlick to discuss the crucial role Big Data plays in helping organizations align their marketing and sales teams to maximize overall effectiveness and productivity.read more
Customer Experience Matrix – Bombora feeds B2B intent data to everyone
David M. Raab explores why Bombora's intent data will have 'B2B marketers drooling at the thought of all that data'.read more


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Killeen has a population of 86,911 and is located in Bell county.
For Texas residents, the average tuition for all Killeen court reporting schools for the 2009 - 2010 school year was $1,290.00. For non-residents, the average tuition for Killeen court reporting schools was $4,200.00.
The average cost of books and supplies for court reporting schools in Killeen is $1,575.00. Students who live on campus while attending a court reporting school in Killeen, can expect to pay an average of $4,639.00 for room and board. Students who live at home can expect average costs to be $3,107.00. Students have a choice of one court reporting college in Killeen to attend. In the 2008 - 2009 school year, reportedly 8 students completed court reporting programs in Killeen.


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To test the feasibility of a framework for prioritizing new comparative effectiveness research questions related to management of primary open-angle glaucoma (POAG) using practice guidelines and a survey of clinicians.
Cross-sectional survey
Members of the American Glaucoma Society
We restated as an answerable clinical question each recommendation in the 2005 American Academy of Ophthalmology Preferred Practice Patterns (PPPs) regarding the management of POAG. We asked members of the American Glaucoma Society to rank the importance of each clinical question, on a scale of 0 (not important at all) to 10 (very important), using a two-round Delphi survey conducted online between April and September 2008. Respondents had the option of selecting "no judgment" or "research has already answered this question" to each question in lieu of the 0 to 10 rating. We used the ratings assigned by the Delphi respondents to determine the importance of each clinical question.
Ranking of importance of each clinical question
We derived 45 clinical questions from the PPPs. Of the 620 American Glaucoma Society members invited to participate in the survey, 169 completed the Round One survey; 105 of 169 also completed Round Two. We observed four response patterns to the individual questions. Nine clinical questions were ranked as the most important: four on medical intervention, four on filtering surgery, and one on adjustment of therapy.
Our theoretical model for priority setting for comparative effectiveness research question is a feasible and pragmatic approach that merits testing in other medical settings.
Comparative effectiveness research (CER), "the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat and monitor a clinical condition, or to improve the delivery of care,"1 serves as the foundation for evidence-based practice and decision making, and is one of the top priorities of the nation's health care agenda.2 Findings of CER inform patients, providers, payers, policy makers and others about the treatments that work best for a defined group of patients under specified conditions, and whether more extensive or expensive management leads to better health outcomes.3,4 Substantial investment of resources is required to conduct new primary studies or to synthesize existing evidence regarding the clinical effectiveness and appropriateness of interventions that are used to manage health conditions. For clinical questions about intervention effectiveness, randomized controlled trials (RCTs) and systematic reviews of RCTs are generally considered to be the highest level of evidence.5
To conserve resources and to obtain the answers that decision makers need, increased attention has focused on ways to prioritize CER. The Institute of Medicine (IOM), for example, was asked by the United States Congress to recommend research priorities that present the most compelling need for evidence of comparative effectiveness considering input from all stakeholders. 2, 6
While the necessity to establish CER priorities is well recognized, there is little empirical evidence to guide the criteria and processes for priority setting. Many organizations report using a nomination-based approach and use similar broad criteria for setting priorities, including cost, burden of disease, public interest, topic controversy, new evidence, impact on quality of life, measurable patient outcomes, and the potential to reduce variations in clinical practice.7–9
The objective of this study was to test a framework for prioritizing clinical questions for new CER starting with clinical practice guidelines. We believe that clinical practice guidelines reflect the state of knowledge in the clinical community regarding prevention, screening and therapy, as well as the community's interpretation of evidence,10, 11 and provide a reasonable starting point for priority-setting. We used the American Academy of Ophthalmology (AAO)'s practice guidelines, the Preferred Practice Patterns (PPPs),16 for primary open-angle glaucoma (POAG), last updated in 2005 (http://one.aao.org/CE/PracticeGuidelines/PPP.aspx; accessed March 21, 2010), as a topic area for testing the framework. We selected POAG because of its substantial burden on patients and health care resources.12–15 AAO PPPs for POAG have been used in the United States, and have been referenced in international glaucoma guidelines.16
In 2006, we developed a list of clinical questions about POAG that could be addressed by clinical trials and systematic reviews of trials (e.g., questions about intervention effectiveness) that we proposed to send to clinicians with a request to rank their relative research priorities. To do this, two individuals independently reviewed the 2005 AAO PPPs on the management of POAG and extracted every statement that could be considered as a recommendation. We restated each recommendation as an answerable clinical question based on characteristics of the patient population, test and comparison interventions, and outcomes.17 We did not translate into clinical questions guideline statements on disease definition, etiology, screening, and diagnosis; statements that we classified as ethical or legal statements; or statements that were not recommendations.
In the PPP, the AAO panel "rated each recommendation according to its important to the care process (http://one.aao.org/CE/PracticeGuidelines/PPP.aspx; accessed March 21, 2010)." We extracted the assigned importance rating for each AAO recommendation, defined as: "level A," most important, "level B," moderately important, and "level C," relevant but not critical. Not all recommendations were rated.
We consulted with three glaucoma specialists who have expertise both in the management of glaucoma and in forming answerable clinical questions to confirm that our restatement was accurate. We also consulted the Cochrane Eyes and Vision Group US Satellite (CEVG@US) Advisory Board and methodologists on the accuracy of the restatements and on our proposal to ask ophthalmologists to rank the relative importance of each question. This revealed that many ophthalmologists are uncomfortable ranking clinical questions outside their sub-specialty. Furthermore, when we pilot tested the survey, some clinicians responded to our request as if we were asking about their knowledge rather than prioritization. The clinician advisors also suggested that we add a response option "research has already answered this question" to our survey. We modified the survey questionnaire and methods accordingly.
Between April and September 2008, we surveyed the membership of the American Glaucoma Society (AGS), asking them to rank the relative importance of the clinical questions we derived from the AAO PPPs for POAG using two rounds of an online Delphi survey. The format of the questionnaire and the data collection plan were adapted from the defining Standard Protocol Items for Randomized Trials (SPIRIT) Initiative Delphi Survey.18 The Johns Hopkins Bloomberg School of Public Health Institutional Review Board (IRB) approved the Delphi survey on March 13, 2008 (IRB number: 00001124). The AGS Research Committee approved the Delphi survey and their role on March 26, 2008.
Round One of the survey, which included the initial invitation, consent to participate, and access to the survey website, was sent by the AGS office via email to their membership list of 620 people. The invitation was signed by the Chair of the AGS Research Committee (Dr. Henry Jampel). The survey instructions said "Please rate the importance of having the answer to each of the following questions for providing effective patient care" on a scale of 0 (not important at all) to 10 (very important). Participants also had the option of assigning a rating of "no judgment" or "research has already answered this question" to each question in lieu of the 0 to 10 rating. We provided space for comments, questions, and nomination of items not included in the list of research questions derived from PPPs. Additionally, Round One requested demographic and other information such as occupation/field, sub-specialty, and place of employment (e.g., government, industry, academia, other), and experience in clinical trials and systematic reviews. AGS members were given 3 weeks to respond to Round One. After the initial request, an email reminder was sent at the end of week 1, week 2, and 1 day prior to the end of week 3, from the AGS office.
Round Two of the survey was sent electronically to Round One respondents approximately 4 weeks after the completion of Round One. We modified the wording of seven survey questions, for clarity only, using feedback from Round One. In Round Two, we provided each respondent with his/her previous individual rating for each question, as well as a summary, in the form of a histogram, of all responses for each question. Respondents were asked to re-rate each clinical question in light of ratings and comments from the previous round. In Round Two we also asked respondents "Please rate the amount you have relied on the AAO PPPs for POAG in deciding how best to provide effective patient care" on a scale of 0 (none) to 10 (heavy). Demographic questions asked in Round One were not asked again in Round Two. Round One respondents were given 3 weeks to respond to Round Two. After the initial request, and at the end of week 1, the study moderator (TL) sent an email reminder. To increase response, the Chair of the AGS Research Committee sent an email reminder at the end of week 2, and 1 day prior to the end of week 3, with a personalized message encouraging participation.
To analyze the survey data, we fitted a 3-level hierarchical model to allow for dependence among the responses observed for units belonging to the same cluster (responses are clustered within question and clustered within respondent). We assumed a normal likelihood for ratings assigned by respondents, and chose non-informative prior distribution for each parameter. We calculated the mean rating and the 95% credible interval for each question using Markov chain Monte Carlo (MCMC) methods in WinBUGS 22.214.171.124 In Bayesian statistics, a credible interval is a posterior probability interval that is used similarly to confidence intervals in frequentist statistics. We categorized ratings into three levels resembling the system used by the AAO PPPs: "most important," "moderately important," and "relevant but not critical." "Most important" questions were those with a lower credible limit (2.5% percentile) above the overall mean; "moderately important" questions were those with 95% credible intervals that include the overall mean; and "relevant but not critical" questions were those with an upper credible limit (97.5% percentile) below the overall mean. We compared the ratings assigned by the Delphi respondents with the associated importance rating assigned in the AAO PPPs.
We initially coded "research has already answered this question" and "no judgment" as "missing" in the analysis. We conducted sensitivity analyses, assigning a 10 for "research has already answered this question", and compared ranks under this assumption. A "sensitivity analysis" repeats the primary analysis, substituting alternative ranges of values for decisions that are subjective, and is used to examine how robust the findings are.17 In assigning a 10 for "research has already answered this question" we assumed that sufficient research to answer a question indicates that the question is important and a systematic review is warranted.
We derived 45 clinical questions from the AAO PPPs related to management of POAG (Table 1, available at http://aaojournal.org): 13 on medical interventions, eight on laser trabeculoplasty, 20 on filtering surgery, one on cyclodestructive surgery, and three on adjustment of therapy.
Of the 620 AGS members invited to participate in the survey, 169 completed the Round One survey; 105 of 169 also completed Round Two (Table 2). The number of responses per day increased when reminder emails were sent. In Round Two, the number of responses per day peaked when the reminder email was sent by the Chair of the AGS Research Committee. We compared the characteristics of those who completed Round One, Round Two, and those who completed Round One but not Round Two (Table 3). Respondents who classified themselves in Round One as "at least moderately experienced in clinical trials as an investigator," as "ever (co)-authoring a systematic review," or as "self-employed/private practice" were less likely to complete Round Two. In Round Two, the mean score for respondent's level of reliance on AAO PPPs for providing effective patient care was 5.2 (standard deviation=2.7; range: 0 to 10).
We observed four response patterns to the individual questions (Figure 1): 1) the majority (>50%) of respondents said that the clinical question had been answered by the research; 2) respondents varied in their opinions of the importance of the research question and a few (≤10%) said that the clinical question had been answered by research; 3) respondents varied in their opinions of the importance of the research question and a substantial proportion (>10% and ≤50%) said that the clinical question had been answered by research; 4) some respondents may not have understood the clinical question, indicated by high frequency of "no judgment" and the written comments. For example, 8/169 respondents in Round One commented that they did not understand question 13 "Are interventions (e.g., repeated instructions, patient education) effective for improving adherence to medical therapy and efficacy of medical therapy in patients with POAG?" In addition, respondents sometimes answered the clinical question or nominated new clinical questions and appeared less interested in or aware of our methodologic goal of setting research priorities. For example, for question 45 "What is the optimal interval for conducting follow-up visits to assess the response and side effects from washout of the old medication and onset of maximum effect of the new medication," 12/169 respondents in Round One provided an optimal follow-up interval, ranging from 4 to 6 weeks. An example of a nominated clinical question is whether beta-blockers stop progression of POAG.
We calculated the mean and 95% credible intervals for the ratings of importance for 45 clinical questions (Figure 2). When "no judgment" and "research has already answered this question" were coded as missing, questions 1, 2, 3, 7, 13, 23, 25, 33, 39, 40, 41, 42, and 43 were ranked as the most important clinical questions to which answers are needed for providing effective patient care, with their lower 2.5% credible limits above the overall means.
We performed a sensitivity analysis, assigning a rating of 10 to response option "research has already answered this question" ("no judgment" was coded as missing), and again compared ranks of the 45 clinical questions. Nine questions (1, 2, 3, 7, 25, 33, 39, 40 and 43) were classified as the most important clinical questions under both coding strategies (Figure 3 and Table 4): four on medical intervention, four on filtering surgery, and one on the adjustment of therapy. The proportion of respondents selected "research has already answered this question" ranged from 7% to 68% in Round One, and 6% to 89% in Round Two for these 9 questions. Respondents who changed from assigning a score in Round One to selecting "research has already answered this question" in Round Two were less likely to report expertise in clinical trials and systematic reviews. Questions 13, 23, 41, 42, were classified as the most important clinical questions when "research has already answered this question" was coded as missing, and questions 4, 5, 14, 21, 22, 26, 28 were classified as the most important clinical questions when "research has already answered this question" was coded as 10, but not under both coding strategies (Figure 3). When the highest ranking questions under both coding assumptions were compared to the AAO importance ratings, 4/9 questions that the AGS members ranked highly in our Delphi survey received a "level A" rating in the AAO PPPs, while 5/9 questions were unrated by AAO (Table 4).
Using questions derived from clinical practice guidelines, and a survey of glaucoma specialists, we generated a ranked list of clinical questions for comparative effectiveness research related to the management of POAG. The questions to which clinicians assigned the highest importance ranking related to the effectiveness of medical interventions, filtering surgery, and adjustment of therapy. Clinical questions on laser trabeculoplasty and cyclodestructive surgery were ranked as less important. The clinical questions that respondents ranked as the most important involved either common clinical scenarios that practitioners face several times daily, such as the decision to use eye drops to lower the intraocular pressure, or less common scenarios, such as interventions after filtration surgery for which practitioners may lack knowledge about their utility.
The top five questions receiving a high importance ranking under both coding schemas were also ranked as "research has already answered this question" by more than 50% of respondents. This may indicate the existence of evidence, for example, from one or two trials that has convinced many clinicians, but not others. It is particularly interesting that the proportion responding that "research has already answered the question" increased after respondents had the opportunity to view the responses by others. We do not know whether those changing their responses were prompted to check the evidence or whether they were simply influenced by their peers.
The clinician survey rankings agreed with the AAO importance rankings in cases where importance rankings had been assigned. We frequently derived more than one clinical question from each AAO PPP recommendation, however. For example, for the PPP statement that medical interventions are generally effective for POAG, we derived seven questions, specifying each type of medical intervention (e.g., beta-blockers) as a unique question. This may explain why over half of the survey questions did not have an AAO importance ranking.
Two main steps are involved in any priority setting effort: identifying important answerable clinical questions, and prioritizing the list of questions using a specific methodology. Our approach for identifying important questions used direct clinician input. Because practice guidelines typically are developed by professional societies aiming to assist healthcare practitioners with decision making,11 the clinical questions derived from them reflect key issues and dilemmas facing clinicians at the time of guideline development.
Our study also used Delphi survey methods, a formal consensus technique, which incorporates individual value judgment into group decision-making. This method is in contrast to nomination-based methods in which, first, topics may be suggested by curious investigators, by payers concerned about cost, or members of the public concerned about contradictory claims of a treatment's efficacy, and then explicit pre-decided criteria are applied to develop rankings.7, 8, 20–22 In certain cases, these other methods have not demonstrated satisfactory validity.21
Our method has several unique strengths. First, by surveying AGS members, we have queried a large group of stakeholders with highly specialized knowledge. This group of experts allowed us to examine a broad range of interventions for the same condition, thus meeting the urgent needs of practitioners to answer myriad questions within the subspecialty. In contrast, most priority setting methods in use focus on just a few questions in a specialty area. This is especially true for vision research. Since their start in 1997, the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Centers (EPCs), the key U.S. producers of systematic reviews, have released only three eye and vision related evidence reports out of a total of 185 evidence reports completed.23 The recent Institute of Medicine report "Initial National Priorities for Comparative Effectiveness Research,"6 recommending research priorities for $400 million allocated by the American Recovery and Reinvestment Act fund to the Department of Health and Human Services, includes only two topics related to vision heath. While dealing with important topics, these reviews and nominated priority topics do not begin to address the important clinical questions of vision subspecialists.
Second, our method promises to lessen the gap between evidence generation and the translation of evidence to care, when the method is used in partnership with guideline developers, research funders, evidence producers, and consumers. We propose the following approach to filling the evidence gaps in a subspecialty area: 1) choose a topic area and work with guidelines producers to derive answerable clinical questions from existing guidelines; 2) survey members of one or more professional associations to assess individual and consensus rankings of the clinical questions; 3) determine evidence needs and research priorities by matching the ranked questions with existing evidence; 4) partner with funders, evidence producers, and evidence synthesizers (e.g., groups within The Cochrane Collaboration such as the Cochrane Eyes and Vision Group) to fill the information gaps.
Our approach can also be used to re-assess research priorities when novel medicine and technology emerge, new evidence gaps develop, and healthcare resources need to be re-allocated to meet these immediate needs.
Given our goal of developing a framework for prioritizing comparative effectiveness research, we faced several challenges. First, when translating the AAO guidelines into answerable clinical questions, we relied on interventions and outcome measures that were stated explicitly in the guidelines. One consequence was that intraocular pressure was over-emphasized as an outcome in the restated clinical questions. In addition, by their nature, practice guidelines may not cover all important clinical questions; the fact that respondents nominated new questions provides evidence regarding this issue.
A second challenge was that some clinicians failed to grasp that our purpose was research prioritization. At both the pilot testing and survey stages of the study, clinicians sometimes responded to the questions as if we were asking about their knowledge of the subject. We found that questions related to the delivery of care (e.g., behavioral interventions, pre- and post- operative care) appeared to be the most difficult in this regard.
We faced a particular challenge in analyzing clinical questions where a meaningful proportion of respondents selected "research has already answered the question," a response option suggested by a clinician co-investigator. Although we performed sensitivity analyses to test how priority ratings would change under two different assumptions, neither approach provides information about whether research indeed has answered the questions and how existing evidence influenced a respondent's interpretation of the question. To address these issues would require matching existing systematic reviews and RCTs to the 45 clinical questions. In future applications of our method, it may be useful to separate response options into two parts: 1) "Please rate the importance of having the answer to each of the following questions for providing effective patient care," and 2) "Do you believe research has already answered each question?" so that responses can be analyzed separately. One could also ask respondents to cite the evidence if they say "research has already answered this question."
High response variability may be used as an alternative criterion to prioritize clinical questions for additional research. Questions with high response variability (which would result in a wide credible interval) might reflect greater clinical uncertainty, and may be more suitable for additional research. In our study, however, response variability was small for all questions. Regardless, it is critical to search for and synthesize existing evidence for clinical questions identified as priorities by preparing, maintaining and disseminating systematic reviews, a necessary step prior to investment of research funds.24
Although our Delphi survey response rate was comparable to other web-based surveys of medical specialists,25 the opinions and rankings of our respondents may not be comparable to those of other American glaucoma specialists since fewer than one third of AGS members responded to the survey. In addition, those who responded to both Round One and Round Two were less likely to report expertise in clinical trials and systematic reviews, and were less likely to identify themselves as self-employed/private practice than those responding to Round 1 only, which may have influenced the final rankings.
If providers and patients are to make well-informed decisions about health care, comparative effectiveness research must be prioritized and conducted with all due speed. Prioritization of the generation and synthesis of research evidence to prevent, diagnose, treat, and monitor clinical conditions should reflect the most urgent needs. Those setting priorities report experience but little empirical evidence as to effective methods of prioritization.8, 22 Our study provides evidence supporting the practicality of a systematic method to identify priority questions utilizing stakeholder input.
In conclusion, we tested the feasibility of a framework for prioritizing answerable clinical questions for new comparative effectiveness research by using practice guidelines and a survey of clinicians. Our approach is systematic, transparent, participatory, and produces a ranked list of questions in a subspecialty area. We have demonstrated that our theoretical model for priority setting for comparative effectiveness research question is a pragmatic approach that merits testing in other medical settings.
We acknowledge valuable clinical and methodological perspective provided by Drs. Richard Wormald, Donald Minckler, and David S. Friedman for the Cochrane Eyes and Vision Group US Project (CEVG@US) Advisory Board, who helped to verify that our restatement from guidelines was accurate and our research plan was feasible. We thank Dave Shade who developed the survey webpage and database.
Financial Support:
This study was supported by the Cochrane Collaboration Opportunities Fund, and Contract N01-EY2-1003, National Eye Institute, National Institutes of Health, USA.
The sponsor or funding organization had no role in the design or conduct of this research.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Meeting Presentation:
Evidence-based Priority-setting for New Systematic Reviews and Randomized Controlled Trials: a Case Study for Primary Open-angle Glaucoma. Presented at the 30th Society for Clinical Trials Annual Meeting, Atlanta, GA. May 2009
Evidence-based Priority-setting for New Systematic Reviews: a Case Study for Primary Open-angle Glaucoma. Presented at the XVI Cochrane Colloquium, Freiburg, Germany. October, 2008
Conflict of Interest:
Dr. Jampel is a consultant for Allergan, Glaukos, Ivantis, Endo Optics, Sinexux, and owns equity for Allergan. Other authors have no financial/conflicting interests to disclose.
Online only material:
This article contains online-only material. The following should appear online-only: Table 1. Statements in the American Academy of Ophthalmology primary open angle glaucoma Preferred Practice Pattern translated into clinical questions.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Xerox Senior Financial Analyst UK with English in Romania
• Responsible for the production of consolidated financial and/or regulatory reporting from a legal entity perspective for internal and external bodies, in accordance with statutory and regulatory requirements.
• This position is primarily responsible for accounts payable, recording receipts, preparing bank deposits, making general ledger entries, reconciling accounts and providing customer service.
• Performs a variety of more complex clerical and accounting functions within the Accounting department.
• Senior level job with considerable work experience
• Has developed specialized skills or is multi-skilled through job-related training
• Completes a variety of atypical assignments
• May solve problems of a recurring nature, but takes a broad perspective to problems and may identify new, less obvious solutions
• Completes work with a limited degree of supervision
• Acts as an informal resource for colleagues with less experience
• May lead a team in the performance of a variety of tasks that are generally routine
• May have specialized external certification (technical roles)
Primary Responsibilities:
• Processes, verifies and audits invoices, expense reports, journal entries, purchase orders, etc.
• Balances items, entries or amounts related to documents processed
• Reconciles general ledger accounts, prepares balance sheet reconciliation and clears exception items
• Posts ledger and general journal entries
• Responds to some routine, but mostly complex questions related to area of responsibility
• All other duties as assigned
Candidate Education:
Minimum High School Diploma / (GED) / Secondary School GCSE or equivalent
Preferred Associate Degree / College Diploma /Cegep / A Levels Degree requirements vary by region
Candidate Background:
Minimum Able to plans and organize work so the Service Level Agreement objectives are realized
Minimum Maintains positive work relationships with members of other teams to ensure compliance with cross-team responsibilities
Minimum Assists in establishing and maintaining strong, collaborative relationships with internal and external customers to identify additional ways to be of service and ensure customer satisfaction
Minimum Knowledge of basic accounting and finance practices
Minimum Proven ability to work under pressure handling multiple tasks to ensure timely completion of all activities
Minimum Demonstrated analytical and problem solving ability
Minimum Versatility, flexibility, and a willingness to work enthusiastically within an environment of changing priorities
Minimum Strong organizational, problem-solving, and analytical skills.
Minimum Excellent organisation and time management skills.
Minimum Previous experience of handling customer queries face to face or telephone
Minimum Experience using computer applications used in performance of role
Minimum Excellent systems literacy knowledge – MS Office, Excel, Word, Internet, Web Conferencing
Job: Accounting
Organization: Global Document Outsourcing Business Group-X000000060
Title: Senior Financial Analyst UK with English
Location: Romania
Requisition ID: 17000261


text:
RememberSet a Reminder for the Anniversary
Joyce M. Lord
- February 4, 1937 - October 10, 2016
- Warner Robins, Georgia
of Joyce's Passing
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Make a Memorial Donation
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Joyce was born on February 4, 1937 and passed away on Monday, October 10, 2016.
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D700 and Macro len
Started Jul 27, 2012 | Discussions thread
Shop cameras & lenses ▾
BearsMom OP • Regular Member • Posts: 179
Re: D700 and Macro len
In reply to just Tony • Jul 28, 2012
Hi Guys
Thanks for all the input. With all the information Ive gathered it would seem this lens is good enough to repair and nothing else fits the price range. Nikon still sells it new for $400.
I think Ill risk having it repaired vs buying one on Ebay. I know what kind of life this lens has had and if I listed it for sale I could say honestly 'like new' except for the dried up lubricant.
I'll make note of the 105 mm lens. I have a 105mm f 1.8 portrait lens that I love but it only focuses to 3.5 feet.
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The Mysterious Stranger Manuscripts
2nd Revised edition
By (author) Mark Twain
Edited by William M. Gibson
Introduction by William M. Gibson
Format: Paperback
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Mysterious Stranger Manuscripts by Mark Twain
Book DescriptionSix years after Mark Twain's death, Albert Bigelow Paine, the author's literary executor, brought out a bowdlerized edition of "The Mysterious Stranger", which he patched together from Mark Twain's three unfinished manuscripts, produced, Paine asserted, during a period of supposed creative paralysis. Scholars have since discovered that Paine's edition of the book was largely based on the earliest of those three versions, onto which Paine then grafted the final chapter of the last version. Indeed, Paine changed so many of the book's essentials that it cannot be said to accurately reflect the author's mood and thought at all. Gibson's volume, first published in 1969 and now back in print, presented the manuscripts for the first time exactly as Mark Twain wrote them. Here, the reader is offered a glimpse of Mark Twain's creative process on what many critics consider the finest fiction of his later years. While the work was begun in 1897 and revised first in 1902 and then in 1908, the third version was the only manuscript actually titled "The Mysterious Stranger". These texts provide a rare opportunity to observe Mark Twain's sustained literary struggle with a central theme.
Buy Mysterious Stranger Manuscripts book by Mark Twain from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780520246959
(203mm x 133mm x 31mm)
Pages: 493
Imprint: University of California Press
Publisher: University of California Press
Publish Date: 31-Aug-2005
Country of Publication: United States
Books By Author Mark Twain
Adventures of Tom Sawyer, Paperback / softback (May 2017)View all books by Mark Twain
Originally published: Minneapolis: Stone Arch Books, 2007.
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William M. Gibson was Professor of English at New York University.
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Is Aris Exhibition & Contracts incorrect or missing key business information? Update your Hotfrog listing today.
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Psyche and Symbol
A Selection from the Writings of C.G. Jung
By (author) C. G. Jung Violet de Laszlo
Edited by R. F. C. Hull
Format: Paperback
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Psyche and Symbol by C. G. Jung
Book DescriptionThe archetypes of human experience which derive from the deepest unconscious mind and reveal themselves in the universal symbols of art and religion as well as in the individual symbolic creations of particular people are, for C. G. Jung, the key to the cure of souls, the cornerstone of his therapeutic work. This volume explains the function and origin of these symbols. Here the reader will find not only a general orientation to Jung's point of view but extensive studies of the symbolic process and its integrating function in human psychology as it is reflected in the characteristic spiritual productions of Europe and Asia. Violet de Laszlo has selected for inclusion in Psyche and Symbol five selections from Aion: "The Ego," "The Shadow," "The Syzygy: Anima and Animus," "The Self," and "Christ, A Symbol of the Self." The book continues with "The Phenomenology of the Spirit in Fairy Tales," "The Psychology of the Child Archetype," and "Transformation Symbolism in the Mass." Also included are the foreword to the Cary Banes translation of the I Ching, two chapters from Synchronicity: An Acausal Connecting Principle, "Psychological Commentary on The Tibetan Book of the Dead," and "Commentary on The Secret of the Golden Flower."
Buy Psyche and Symbol book by C. G. Jung from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780691019031
(203mm x 127mm x 27mm)
Pages: 424
Imprint: Princeton University Press
Publisher: Princeton University Press
Publish Date: 1-Feb-1991
Country of Publication: United States
Books By Author C. G. Jung
Dream Interpretation Ancient and Modern, Paperback (December 2016)View all books by C. G. Jung
"Published with the support of the Philemon Foundation."
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Hotfrog NewZealand provides information regarding Rangitoto Medical Clinic in Auckland. Rangitoto Medical Clinic is located at 4 Rangitoto Road, Auckland Auckland 2025 and provides Healthcare services. Contact them on 09-278 5320.
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19A Orbit Drive Albany Auckland 0745
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Shop 4, The Zone 14 - 28 Subway Road Auckland 2120
Level 12 45 Queen Street Auckland 1010
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Microsoft's very new hot topic among users is the Project Spartan which is the new web browser available in Windows 10 Technical Preview build 10049 and later. It is not yet decided to give a final name to the new browser, also the old Internet Explorer browser is still available in Windows 10.
If you want to use and test the Spartan Web Browser then you can download Windows 10 Technical preview from the following link :
Download Windows 10 Pro Technical Build 10056 [Latest]
Lets get to know about Spartan more, which most of the users are eager to know and are not able to use it as they are not using Windows 10 yet. So the first and foremost question that arises on everybody's mind is why another browser when there are already very popular and stable browsers are available in the market such as Google Chrome, Mozilla Firefox, Opera, etc? The answer is that users get a better compatibility, better performance and better support for the new and well developed browser from Microsoft, the main motto of the company is to let its users use the default browser rather opting for other 3rd part web browsers.
Will Microsoft Remove Internet Explorer from Windows 10?
Microsoft is never going to remove its popular and oldest browser Internet Explorer as it is the main component of its Operating System and they are also planning to keep both the browsers in their next builds.
Spartan web browser will be featuring a new rendering engine that will support the modern HTML websites and also provide a better compatibility and performance unlike Internet explorer and it will be the default web browser in Windows 10.
[su_note note_color="#fb4c39″ text_color="#ffffff"]The User Interface is Neat & Clean[/su_note]
Spartan web browser looks clean and has the metro looks, as you can see the tabs are also shown in the title bar and has ample gap in the address bar along with toolbar buttons such as back, forward, refresh, reading view, bookmark, etc
The Smiley button is to send a feedback if you have something else in your mind for the changes or if you feel something is missing. You can also report a bug using this button and it will directly go the bug testing team for Project Spartan.
Features of Spartan Web Browser :
- Built in Cortan – Cortana is personal assistance in Project Spartan which makes your web browsing easier and helps you do thing in a much easier way. She is there to help you in the background and assist you with whatever you need.
- New and Unique Look – Spartan breaks the ice with an incredible look and an easy to use interface, which has redesigned and carries a 'clean' look.
- Built-in note-taking – This next generation browser by Microsoft gives you inking capabilities. Which means, Spartan enables you to take notes, write, type directly on your page. For those who indulge in research and collecting information, this feature makes their work incredibly easy as they can save their notes directly into OneNote.
- Sharing – In addition to inking, Spartan also allows you to share your notes with whoever you want. You can share it with your friends on Social Media or you can simply email it to someone as per your requirement. It makes your communication extremely easy to capture and share.
- Your own Reading List – Spartan offers you help in creating your own Reading List. The internet is a place with limitless and overloaded information, to help you sort it out, this reading list collects the required information to give you the access later on for your reference.
- Reading View – Web surfers also have an access to the integrated Reading View, which focuses only on the content.
- Modern Web Browser – The unique rendering engine of Spartan is built with the idea to make the web work faster, in a secured and reliable way.
- Optimized for YOUR Device – Spartan is optimized in itself to suit all your devices so that you have no inconvenience when it comes to easy and hassle free surfing and browsing.
- Secure and Power Efficient – It is Power efficient, more secure and perfect in every way, including tabs, address bars and so on.
You can even download other browsers if you are not having Windows 10 Technical Preview from the following link :
[su_button url="http://techolaty.net/top-5-windows-pc-browsers-download/" style="flat" background="#ff6559″ size="5″ radius="0″ icon="icon: external-link"]Top 5 Windows PC Browsers Download[/su_button]


text:
For rent by Maximo Properties MEMBER16 Feb 4:23 pmAdjiriganor, Accra
5 bedroom house available for rental at Adjiriganor, East Legon. It has 2 halls, tiled floors, 3 washrooms in the main house, fans and wardrobes, a fitted kitchen, lawn, double garage, 2 bedroom boys-quarters, paved compound, etc. Property is ideal for office or residence. Price per month is 1,700 US Dollars. Call Maximo Properties now.
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text:
From: "Donald Eaves" <firstname.lastname@example.com>
Dell Perry writes:
>OK, OK, so I listed 26 - sue me!!!
Okay. I will. Anner's not trying to compile this stuff.
Seriously, I was delighted to see your list. Since I'm having trouble
with all the median class, I was especially interested to see that a
fellow Texan is having success and will particularly note those on the
Alas, you folks even have more time to get a list out. Sad to say that
this weekend while I was playing around with sorting the info I had
already entered, I managed to get a whole column disassociated from
the other columns. This did not make the list entirely unusable for
me, but it did mean that info I will need was no longer associated with
the cultivars with which it was sent. End result is that I started over
from scratch on entering new data, since I now have a better idea of
what I'm going to need in the end. I will still use the old list, but in an
abbreviated manner from what I'd intended. At this point I have more
than half the data reentered with additional information which I didn't
pick up the first go 'round. Just playing with the sort options is fun. I
at least have some interesting data to call up. When I messed it up
there were nearly 1100 line entries, one per mention per list. Ultimately,
the intention is to reduce multiple entries for a cultivar to one line with
accumulated data.
I should take precautions so I don't do it again, but so far I'm over-
confident in my ability not to repeat the mistake and haven't gotten
'round to it.
Donald Eaves
Texas Zone 7 - who received a very nice list from a talker by private
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Delegates from 190 nations will gather on the resort island of Bali for the largest global warming conference ever, bringing more than 10,000 people together for two weeks of marathon discussions, including Hollywood stars, former US Vice President Al Gore, fishermen and drought-stricken farmers.
World leaders will attempt to launch negotiations leading to a replacement for the Kyoto Protocol, which expires in 2012. Among the most contentious issues will be whether emission cuts should be mandatory or voluntary and how to help the world's poorest countries adapt to a worsening climate.
Yvo de Boer, general secretary of the UN Framework Convention on Climate Change, said the role of the United States "would be critical" in the discussions and that delegates must come up with a roadmap that is embraced by Washington.
"To design a long-term response to climate change that does not include the world's largest emitter and the world's largest economy just would not make any sense," he told reporters.
The US, which along with Australia refused to sign the Kyoto Protocol, said ahead of the Bali talks that it was eager to launch negotiations, but has been among industrialised nations leading a campaign against mandatory emission cuts.
But now the US may find itself isolated at the conference, given that Australian Prime Minister-elect Kevin Rudd, whose party swept to power in general elections just one week ago, immediately put signing the Kyoto pact at the top of his international agenda.
US President George Bush, trying to fend off charges that America is not doing enough, said this week that a final Energy Department report showed American emissions of carbon dioxide, a leading greenhouse gas, declined by 1.5 percent last year while the US economy grew.
"Energy security and climate change are two of the important challenges of our time. The US takes these challenges seriously," he said in a statement. "This puts us well ahead of the goal I set in 2002."
The two-week meeting comes after a Nobel Prize-winning UN network of scientists issued a landmark report concluding the level of carbon and other heat-trapping "greenhouse gas" emissions must be stabilised by 2015 and decline from there to stave off the worst effects of climate change.
- More about:
- Al Gore
- Bali
- Conferences
- Drought
- Global Warming
- Kyoto Protocol


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Due to multiple problems over the last few days with my site going down, Lady V dZine is moving to That Bald Chick NOW.
All posts, contests, comments, etc, have been moved to the new site.
Please bear with me as I fix the links over the next few days.


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Business, Management and Economics
Total Quality Management and Six Sigma
Edited by Tauseef Aized, ISBN 978-953-51-0688-3, 306 pages, Publisher: InTech, Chapters published August 01, 2012 under CC BY 3.0 license
Edited Volume
In order to survive in a modern and competitive environment, organizations need to carefully organize their activities regarding quality management. TQM and six sigma are the approaches that have been successful in solving intricate quality problems in products and services. This volume can help those who are interested in the quality management field to understand core ideas along with contemporary efforts done in the field and authored as case studies in this volume. This volume may be useful to students, academics and practitioners across diversified disciplines.


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Once More | Tamil Full Movie | Sivaji Ganesan, Vijay, Simran, Saroja Devi
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Movie Name : Once More
Cast : Sivaji Ganesan, Vijay, Simran, Saroja Devi and others
Music : Deva
Directed : S. A. Chandrasekhar
Synopsis: Vijay (Vijay) is a rich young business man, whose only one aim in life is to have fun, is the managing director of a big tea estate in Ooty and his company goes on a big loss because of his mismanagement. Vijay spends most of his time in partying and flirting with girls whenever he feels like. To manage the loss to his company, Vijay invites his father Rajasekar (who is in the United States) to come to India to sign some documents. As fate would have it, Vijay's father dies in a plane crash on his way to India. His maternal uncle (Manivannan) comes up with the idea of having another elderly person to act as Vijay's father for a while until the documents are signed. So they visit a senior home, where they meet Selvam (Sivaji Ganesan) and they request him to act as Vijay's father. He agrees to it and starts to act as Vijay's father.
Selvam observes the careless, take-it-easy life style of Vijay and is reminded of his old days when he used to be like Vijay (movie clips from an old Sivaji film Iruvar Ullam come to help). Selvam is very affectionate towards Vijay and he considers him as his son. Vijay finds out about Selvam's past life, that Selvam was married to Shantha (Saroja Devi) and they have been living separated for the past 30 years. He wants them to get united and he searches and finds the whereabouts of Shantha. Meanwhile, Kavitha (Simran) joins Vijay's company and she talks to Vijay in his own style. Vijay is knocked out by Kavitha's beauty and he falls in love with her. Then, their love gets into trouble because of Kavitha's mother. Now, Vijay tries to unite Selvam and Shantha. In return Selvam tries to unite Vijay and Kavitha. Will Selvam and Shantha meet and get married 'Once More'.
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Genetic polymorphisms in CYP2E1: Association with schizophrenia susceptibility and risperidone response in the chinese han population
Huo R.,Shanghai JiaoTong University |
Huo R.,Shanghai Genomepilot Institutes |
Tang K.,Shanghai JiaoTong University |
Tang K.,Shanghai Genomepilot Institutes |
And 21 more authors.
PLoS ONE | Year: 2012
Background: CYP2E1 is a member of the cytochrome P450 superfamily, which is involved in the metabolism and activation of both endobiotics and xenobiotics. The genetic polymorphisms of CYP2E1 gene (Chromosome 10q26.3, Accession Number NC_000010.10) are reported to be related to the development of several mental diseases and to be involved in the clinical efficacy of some psychiatric medications. We investigated the possible association of CYP2E1 polymorphisms with susceptibility to schizophrenia in the Chinese Han Population as well as the relationship with response to risperidone in schizophrenia patients. Methods: In a case-control study, we identified 11 polymorphisms in the 5' flanking region of CYP2E1 in 228 schizophrenia patients and 384 healthy controls of Chinese Han origin. From among the cases, we chose 130 patients who had undergone 8 weeks of risperidone monotherapy to examine the relationship between their response to risperidone and CYP2E1 polymorphisms. Clinical efficacy was assessed using the Brief Psychiatric Rating Scale (BPRS). Results: Statistically significant differences in allele or genotype frequencies were found between cases and controls at rs8192766 (genotype p = 0.0048, permutation p = 0.0483) and rs2070673 (allele: p = 0.0018, permutation p = 0.0199, OR = 1.4528 95%CI = 1.1487-1.8374; genotype: p = 0.0020, permutation p = 0.0225). In addition, a GTCAC haplotype containing 5 SNPs (rs3813867, rs2031920, rs2031921, rs3813870 and rs2031922) was observed to be significantly associated with schizophrenia (p = 7.47E-12, permutation p<0.0001). However, no association was found between CYP2E1 polymorphisms/haplotypes and risperidone response. Conclusions: Our results suggest that CYP2E1 may be a potential risk gene for schizophrenia in the Chinese Han population. However, polymorphisms of the CYP2E1 gene may not contribute significantly to individual differences in the therapeutic efficacy of risperidone. Further studies in larger groups are warranted to confirm our results. © 2012 Huo et al. Source
Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: A meta-analysis
Wu X.,Shanghai JiaoTong University |
Wu X.,CAS Shanghai Institutes for Biological Sciences |
Tang K.-F.,Shanghai JiaoTong University |
Tang K.-F.,CAS Shanghai Institutes for Biological Sciences |
And 21 more authors.
Parkinsonism and Related Disorders | Year: 2012
Leucine-rich repeat kinase 2 (LRRK2, PARK8) gene has attracted considerable attention since the variants in this gene are recognized as the most common cause of Parkinson's disease (PD) so far. A number of association studies concerning variants of LRRK2 gene and PD susceptibility have been conducted in various populations. However, some results were inconclusive. To derive a more precise estimation of the relationship between LRRK2 and genetic risk of PD, we performed a comprehensive meta-analysis which included 27,363 cases and 29,741 controls from 61 published case-control studies. Totally, the effect of five LRRK2 variants all within the coding regions, i.e. G2019S, G2385R, R1628P, P755L and A419V, were evaluated in the meta-analysis using fixed effect model or random effects model if heterogeneity existed. There were genetic associations between four variants (G2019S, G2385R, R1628P and A419V) and increased PD risk, while there was no evidence of statistically significant association between P755L and PD. Publication bias and heterogeneity were absent in most analyses. Within its limitations, this meta-analysis demonstrated that the G2019S, G2385R, R1628P and A419V variations are risk factors associated with increased PD susceptibility. However, these associations vary in different ethnicities. © 2012 Elsevier Ltd. Source
Wu X.,Shanghai JiaoTong University |
Wu X.,Shanghai Institutes of Genome Pilot and Human Health |
Xu Q.-Q.,Shanghai JiaoTong University |
Xu Q.-Q.,Shanghai Institutes of Genome Pilot and Human Health |
And 19 more authors.
PLoS ONE | Year: 2013
Genome-wide association studies (GWAS) have identified several genetic susceptibility loci for breast cancer (BC). One of them, conducted among Chinese women, found an association of rs2046210 at 6q25.1 with the risk of BC recently. Since then, numerous association studies have been carried out to investigate the relationship between this polymorphism and BC risk in various populations. However, these have yielded contradictory results. We therefore performed a meta-analysis to clarify this inconsistency. Overall, a total of 235003 subjects based on 13 studies were included in our study. Significantly increased BC risk was detected in the pooled analysis [allele contrast: OR = 1.13, 95%CI = 1.10-1.17, P(Z) <10-5, P(Q) <10-4; dominant model: OR = 1.21, 95%CI = 1.14-1.27, P(Z) <10-5, P(Q) <10-4; recessive model: OR = 1.18, 95%CI = 1.12-1.24, P(Z) <10-5, P(Q) = 0.04]. In addition, our data revealed that rs2046210 conferred greater risk in estrogen receptor (ER)-negative tumors [OR = 1.27, 95%CI = 1.15-1.40, P(Z) <10-5, P(Q) <10-4] than in ER-positive ones [OR = 1.18, 95%CI = 1.09-1.28, P(Z) <10-4, P(Q) = 0.0003]. When stratified by ethnicity, significant associations were found in Caucasian and Asian populations, but not detected among Africans. There was evidence of heterogeneity (P<0.05), however, the heterogeneity largely disappeared after stratification by ethnicity. The present meta-analysis demonstrated that the rs2046210 polymorphism may be associated with increased BC susceptibility, but this association varies in different ethnicities. © 2013 Wu et al. Source
Systematic functional characterization of cytochrome P450 2E1 promoter variants in the Chinese Han population
Huang X.,Shanghai JiaoTong University |
Huang X.,Shanghai GenomePilot Institutes for Genomics and Human Health |
Chen L.,Shanghai JiaoTong University |
Chen L.,Shanghai GenomePilot Institutes for Genomics and Human Health |
And 11 more authors.
PLoS ONE | Year: 2012
CYP2E1 promoter polymorphisms can lead to significant interindividual differences in expression of CYP2E1. Using a database of CYP2E1 gene polymorphisms established in 2010, our study aimed to functionally characterize the single nucleotide polymorphisms (SNPs) of the promoter region and corresponding haplotypes in the Chinese Han population. Six novel SNPs and seven haplotypes with a frequency equal to or greater than 0.01 were constructed on a luciferase reporter system on the basis of site-directed mutagenesis. Dual luciferase reporter systems were used to analyze regulatory activity. The constructs including single novel SNP mutations exhibited insignificant change in luciferase activity, whereas, the activity produced by Haplo1(GTTGCTATAT), Haplo2 (CTTGCTATAT) and Haplo7 (GAGCTCACAT), containing a -333T>A polymorphism was significantly greater than for the wild type in Hep G2 cells (p<0.05), being 1.5-, 2.0- and 1.4- times greater respectively. These findings suggest the possibility of significant clinical prediction of adverse drug reaction and the facilitation of personalized medicine. © 2012 Huang et al. Source


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Han's Paddles are USA manufactured, designed and sold direct by Coach Dick Hannula. Dick Hannula is the author of "Coaching Swimming Successfully," co-editor of the "Swim Coaching Bible," and inductee coach of ASCA, NISCA, and International Halls of Fame.
Buy direct from Han's Paddles, Inc.
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text: Gábor has been working in the communication industry for more than 20 years; and he joined the Aegis Group 6 years ago as the CEO of Carat. As Head of Customer Management at an integrated communication agency (McCann Erickson) he had gained full-scale experience in the marketing communication industry. As marketing consultant and Head of Marketing at a start-up company he extended his expertise to additional areas.


text:
The Aussie IGN team break down the biggest gaming news over a few cracked tinnies. Everybody wins.
December 3rd, 2012
Episode 50 of 161 episodes
In the latest episode of the IGN AU Pubcast, Jem makes her triumphant return and joins Tristan, Cam, Baker and Luke in the discussion of: Hitman Absolution, and the workout video it inspired, "Fitman: Flab Solution", Black Ops 2 and the worst post-credits ending of all time, Far Cry 3 and punching the sh*t out of sharks, the Wii U launch line-up and our overall view on the system itself, the length of this console cycle and whether it's been damaging to the games industry or not, PLUS all your questions answered and the latest episode of the Pubcast soapie!
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Berkshire Hathaway HomeServices Verani Realty
(888) 723-0306
Listing Provided Courtesy Of: Peabody and Smith Realty/Littleton - Joy Moore
Last Updated: 2/20/2017 12:21 PM
Description for 0 N North Littleton Road Littleton, NH 03561
An out of town lot, a possible mobile home lot. Rural setting within a short commute to either Littleton or Lancaster. There maybe a possible usable spring on the property.
Listing Information
Electric service at street
School Information
Room Information
Exterior / Lot Features
Rural, Public Roads, Wooded
Financial Considerations
Inside AccessTM
Current market conditions for 0 N North Littleton Road
Active Market Trends
Source:MLS DATA
Median list price$225,000
Days on market173
Properties for sale31
Sold Market Trends
Source:MLS DATA
Median sold price$169,500
Sales to list price9,407.0%
Properties sold22
Median sq ft price$82
Arrows indicate 90 day trend
Listing Price History for 0 N North Littleton Road
Littleton Real Estate
Littleton is located in New Hampshire. Littleton, New Hampshire 03561 has a population of 4,608.
The median household income in Littleton, New Hampshire 03561 is $42,727. The median household income for the surrounding county is $53,386 compared to the national median of $53,046. The median age of people living in Littleton 03561 is 45.4 years.
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STARmeterSEE RANK
Up 3,903 this week
Marilee Earle
Marilee Earle was born on June 4, 1934 in Texas, USA. She is an actress, known for The Fearmakers (1958), Terror in a Texas Town (1958) and The Lost Missile (1958). She has been married to Albert N. Zdenek since December 11, 1962. She was previously married to Leonard S. Picker. See full bio »
Born:in Texas, USA


text:
Operation Yes
Written by Sara Lewis Holmes
�Be kind, for everyone you know is fighting a great battle.�
Plan A
Bo is going to behave for his new teacher.
His father, an Air Force colonel, says so.
Gari is going to live peacefully with her cousin.
Miss Loupe is going to teach her class language arts, social studies, math, and science.
Plan B
Gari stages a protest.
And when something happens that none of them could plan for�
they lose Miss Loupe too.
And what comes out of that is�
Plan C
For everyone�s parents. Everyone�s families.
It�s a plan so big, so daring, so life-changing, that it can only be called:
"[T]he most buoyant example of ensemble work since E. L. Konigsburg�s The View from Saturday (1996) and the best of Gregory Maguire�s Hamlet Chronicles. . . . Flicking among points of view with increasing speed, Holmes tracks the blossoming of Bo Whaley, an often-in-trouble kinetic learner who takes to improv like a duck to water; his just-arrived cousin Gari (who will without doubt grow up to be a professional campaign manager); and a supporting cast of gently caricatured classmates, parents, and faculty. Though only a small part is actually written as a script, the entire tale is purest stagecraft: quick, funny, sad, full of heart, and irresistibly absorbing." -- Booklist, starred review
�[T]his story of middle-school classmates who come together to honor their teacher and her war-injured brother entertains. . . . Miss Loupe is the kind of teacher every kid dreams about, and the �all for one, one for all� mentality that comes through as the students band together is inspiring.� -- Publishers Weekly
�In this lively, often funny novel, an enthusiastic teacher brings improv to restless sixth graders at a rundown school on a North Carolina Air Force base. . . . Pitched to readers in both military and civilian families, this engaging story avoids larger questions of war and peace, focusing instead on how they affect the lives of American kids who deal with the consequences every day.� -- Kirkus Reviews
�The classroom is often a place of lessons, but Holmes tells her story�infused with details of military life�with heart and energy, and leaves any didacticism at the door. Sixth graders, military brats or not, will identify with this rich cast.� -- Horn Book
Barnes & Noble
Indie Bound
Fall 2009
Middle Grade Novel
Price: $16.99/$21.99
Trim Size: 5�� x 8��
Page Count: 256
Foreign Rights: ICM
Translation Rights: ICM
Rights Available? yes


text:
Ready For Occupancy House and Lot In Cavite
For sale renovated concrete house and lot located in Barangay 80 San Rafael, Pasay City.
Commercial Lot for Sale in Bay City Area
The country's forefront financial agencies like the Department of Finance or DOF (Kagawaran ng Pananalapi), the Bangko Sentral ng Pilipinas or BSP (Philippines Central Bank)...
This fabulous and spacious 2 Bedroom unit is on the 24th floor. It has a lovely view from all the rooms and the long 10 sqm Balcony. There is a semi-enclosed Kitchen with...
This lovely home was renovated and upgraded with a new covered front porch, new kitchen and built in cabinets and shelves throughout the house. It is situated in the Gated...
This older House is situated on 2 lots with separate clean titles. It is in a great location to demo and build a new House, Townhouse or a Commercial Building. It is in a...
COMMERCIAL LOT FOR SALE IN MACAPAGAL PASAY LOT AREA: 3062 sqm =
Commercial Lot For Sale in Manila Agent : Kenneth Dela Cruz – CP# 09205558011
Buy and Sell Philippines


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University unveils £17m Astbury lab investment
The results of a £17 million investment in advanced biological research equipment will be unveiled at the University later today, when the Astbury BioStructure Laboratory is officially launched.
Better living through microscopy
Two of the most powerful cryo-electron microscopes in the world have been installed in the University's Astbury BioStructure Laboratory.
The new £5m University of Leeds sports facility is to be named after its most successful alumni athletes, Olympic heroes Alistair and Jonny Brownlee.
Biological Sciences careers fair hailed as a great success
The annual Careers Fair here in the faculty was a great success with hundreds of FBS students attending.
Read more
Postgraduate Masters
Research degrees


text:
Best gadgets coming in 2017
Jan 13 2017- POSTED BY Sayantani Singha
New Delhi: 2017 is going to unveil more new gadgets upping the convenience factor. Some of the launches expected are […]Read More
Hong Kong: Nintendo`s hit smartphone app, Pokemon Go, and other augmented reality games are unlikely to be rolled out in […]Read More
New Delhi: The is available to buy in the US from Friday. The key Mate 9 talking is the fact […]Read More
New Delhi: Taiwanese multinational ASUS on Tuesday announced the launch of its R558UQ notebook in two models, the i7 models […]Read More
New Delhi: AppleFest opened on Flipkart on Tuesday, January 10, which will last up to January 13. The AppleFest is […]Read More
New Delhi: Smartphones have really made our lives smart. The modern-day smartphones have become so efficient that they can take […]Read More
New Delhi: Lenovo P2 goes on sale from Thursday. The smartphone is available exclusively on e-commerce site Flipkart. SPECIFICATIONS: DISPLAY: 5.5-inch […]Read More
New Delhi: Xiaomi is going to launch the next generation of its one of the most popular Redmi series, that is Redmi […]Read More
New Delhi: Asus has rolled out the Android 7.0 Nougat update for its Zenfone 3 smartphones, as per reports. Till […]Read More


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Hotfrog Philippines provides information regarding Globe Tattoo in Misamis Occidental. Globe Tattoo is located at B-5, Gaisano Ozamis City Mall, Rizal Avenue corner G/F, Misamis Occidental and provides Retail services.
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text: We have just recently started BLW which is going great,and I've been offering DD,6.5 months, a cup of boiled (cooled!) water to sip with her meal...it's been 5 years between babies so I'm not sure what the go is now in regards to boiling it/not boiling... can I just give her tap water now? Thanks


text:
$ 9.99
Fitjoy - 3 Best Selling flavors
C4 RTDs - 3 Best Selling flavors
What Is It: This is a game changing protein bar that will fill you up but low in carbs and calories. This can be a meal replacement or a post workout snack. The difference between FitJoy and "other" bars is that FitJoy mimics the actual flavor consistency so you don't have that "chewy" experience.


text:
Mielparque Kumamoto Hotel, Kumamoto
- Free WiFi
Main amenities
- 59 guestrooms
- Restaurant
- Self parking
- Air conditioning
- Daily housekeeping
- Front desk safe
- Laundry service
- Conference space
- Gift shops/newsstands
- Luggage storage
For families
- Rollaway/extra beds (surcharge)
- Refrigerator
- Private bathroom
- Daily housekeeping
- Hair dryer
- Elevator/lift
What's around
- Contemporary Art Museum Kumamoto (0.2 mi / 0.3 km)
- Catholic Tetori Church (0.2 mi / 0.4 km)
- Yakumo Koizumi Old House in Kumamoto (0.3 mi / 0.5 km)
- Sakura-no-baba Josaien (0.5 mi / 0.7 km)
- Kumamoto City Hall (0.5 mi / 0.8 km)
Mielparque Kumamoto Hotel, Kumamotofrom $48
- Universal Room, Smoking
- Twin Room, Smoking, River View
- Twin Room, Non Smoking, River View
- Single Room, Smoking
- Twin Room, 2 Single Beds
- Single Room, Non Smoking
- Single Room, 1 Single Bed
More great choices
At a glance
Key facts
Hotel size
- This hotel has 59 rooms
- Check-in time 3 PM-midnight
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi and wired Internet access in public areas
- Free WiFi and wired Internet access in rooms
- Self parking *
Nearby Three Star Kumamoto hotels
In the hotel
- Restaurant
- Conference space
- Dry cleaning/laundry service
- Luggage storage
- Elevator/lift
- Safe-deposit box at front desk
- Designated smoking areas
- Accessible bathroom
In the room
- Air conditioning
- Private bathroom
- Shower only
- Hair dryer
- Flat-screen TV
- Free WiFi
- Phone
- Refrigerator
- Daily housekeeping
- In-room safe
Top Kumamoto hotels
Recently reviewed hotels in Kumamoto
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"The location is a bit remote and the reception area is far from the parking space, we need to carry our luggage through two tunnels before we can reach the reception counter. But…"Oct 24, 2016
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"Our room had twin beds and two futon beds for four people, both were hard by American standards. The breakfast was good but the Keiseki (Japanese seasonal dishes) was great which…"Aug 8, 2016
- Riverside Hotel KumamotoFrom
"I was staying at the hotel the night of the 6.4 earthquake. The hotel staff handled the situation with perfectly. They comforted people in the lobby, giving out food and bottled…"Apr 20, 2016
- Nest Hotel KumamotoFrom
"The hotel was very close to the bus terminal. They also had a kiosk that sold Kumamon merchandise."Apr 11, 2016
Nearby hotels
Also popular with travelers from the USA
Mielparque Kumamoto Hotel, Kumamoto's small print
Also known as
- Mielparque Kumamoto
- Mielparque Kumamoto Hotel
The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file.
Optional extras
Self parking costs JPY 700 per day
Rollaway beds are available for JPY 3500 per stay
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


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[Fishing] Finishing a fishing quest
Discussion in 'UO Fishing and Treasure Hunting' started by Colgarra, Mar 2, 2013.