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David Jordan, PhD Member of the Operations Committee and Project Leader for Clinical Data Standards TransCelerate Biopharma Pre-Competitive Collaboration in Clinical Trials March 17, 2014
Outline TransCelerate Overview –Why –Who –What CFAST Overview Opportunity for Collaboration 2
Click to edit Master title style Why do we need Pre-Competitive Collaboration in Clinical Trials? 3
4 Moore's Law: Transistor Count Doubling Every Two Years Source: Wikipedia
5 Eroom's Law: Number Of New Drug Approvals Per Billion US Dollars Halved Every Nine Years Source: Nature Reviews – Drug Discovery: Diagnosing the decline in pharmaceutical R&D efficiency Vol 11, March 2012, page 191 - 200
6 Some Causes of Declining Productivity in Drug R&D Biomedical R&D increasingly complex* Higher regulatory hurdles * Challenges too large for individual companies to overcome *Source: Nature Reviews – Drug Discovery: Diagnosing the decline in pharmaceutical R&D efficiency Vol 11, March 2012, page 191 - 200
Click to edit Master title style Who is TransCelerate How does it operate? What are its Initiatives? 7
TransCelerate launched September 2012 by ten of the largest global Pharmaceutical companies to advance innovation in drug R&D identify and solve common R&D challenges further improve patient safety Clinical Trial execution identified as a key priority TransCelerate BioPharma - A Response to the Productivity Crisis in Drug Development 8
The Charter Members of TransCelerate Include Ten Major Pharmaceutical Companies 9 TBA (Board Member) David Jordan (Operations Committee) Divisional VP, Stats & Data Mgmt Paul Stoffels (Board Member) Worldwide Chairman of J&J Pharmaceuticals Martin Fitchet (Treasurer to the Board, Operations Committee) Chief Operating Officer Briggs Morrison (Board Member) EVP, Global Medicines Development Sue McHale (Operations Committee) Executive Director, Global Project Delivery Jan Lundberg (Board Member) EVP of Science & Technology Jeff Kasher (Operations Committee) VP and COO Global Medical R&D Klaus Dugi (Board Member) Corporate SVP, Medicines Thor Voigt (Operations Committee) Head of Global Clinical Ops, Biometrics & Data Management John Hubbard (Board Member) SVP Development Operations Craig Lipset (Operations Committee) Head of Clinical Innovation Brian Daniels (Board Member) SVP Global Development & Medical Affairs Jonathan Zung (Chairman, Operations Committee) VP, Global Development Operations Reb Tayyabkhan (Operations Committee) Exec. Director, GDO Business Operations Corsee Sanders (Board Member) Global Head of Development Innov. & Clin Ops Carol Harris (Operations Committee) Global Head Project & Functional Excellence Patrick Vallance (Board Member) President, Pharmaceuticals R&D Lynn Marks (Corporate Secretary) SVP, Clinical Platforms & Sciences Pete Milligan (Operations Committee) VP, Clinical Platforms Transformation Elias Zerhouni (Board Member) President of Global R&D Andy Lee (Operations Committee) SVP, Head Global Clinical Operations
10 Peter Carberry (Board Member) SVP & Head of Global Development Operations Nancy Sacco (Operations Committee) Executive Director, Development Sciences/Strategic Garry Neil (Board Member) Global Head, R&D Annalisa Jenkins (Board Chair) Global Head of R&D Kathleen Ford (Operations Committee) Senior VP, Head of Global Clinical Operations Alfred Sandrock (Board Member) SVP, Head of Development Sciences & CMO Murray Abramson (Operations Committee) VP, Global Clinical Operations Marco Taglietti (Board Member) President, Forest Research Institiute & CMO Ulo Palm (Operations Committee) SVP, Clinical Operations & Biometrics Nine new member companies joined TransCelerate in 2013 Steve Gilman (Board Member) EVP, R&D and CSO Uschi Stoutenburgh (Operations Committee) Senior Director, Clinical Operations Brigitte Koch (Operations Committee) VP, Head Global Clinical Project Management Steve Johnson (Operations Committee) SVP, R&D Business Services Gareth Morgan (Operations Committee) SVP, Portfolio Management, Global Development Office Board Members Non-Board Members
Delivery Strategy Team Structure A flat organization structure has been developed to manage projects and operational activities External Counsel Accounting Firm Board of Directors Initial Workstreams Director of Operations Audit Firm Administrative Asst. Key: Retained Position Contracted Resources Member Representatives Clinical Operations Committee CEO New Workstreams Head of Delivery Excellence & Corp Affairs Finance Lead Special Populations Network Risk Based Monitoring Investigator Collaboration Platform Regulatory Communications Future Initiatives Planning Technology Sub-Committees Redacted CSR Change Management Comparators Network Data Standards Site Qualif. & Training Common Protocol Template Investigator Registry Exploratory Project 1 Exploratory Project 3 Exploratory Project 2 11 Confidential - NOT FOR DISTRIBUTION Director of Projects
Not for profit entity created to drive collaboration as means to developing solutions for overcoming inefficiencies 12 Our vision To improve the health of people around the world by accelerating and simplifying the research and development of innovative new therapies. Our mission To collaborate across the global research and development community to identify, prioritize, design and implement solutions that drive the efficient, effective and high quality delivery of innovative new therapies. Our core values Quality Transparency & Openness Trust & Integrity Collaboration Courage
An Entity that Engages with the Wider Clinical Ecosystem Globally Research and CRO Community Regulatory Bodies Industry Initiatives Investigative sites 13 Confidential - NOT FOR DISTRIBUTION Strategically focusing engagement efforts with selected key stakeholder groups The intent is not to recreate, but partner whenever feasible
Five Selected Areas of Focus Have the Shared Goals of Increased Quality, Patient Safety and Accelerated Development Timelines InitiativeObjectiveBenefitProgress to date Clinical Data Standards – Efficacy (in Partnership with CDISC and CFAST) Accelerate current efforts underway through CDISC to establish efficacy data standards Increased quality of clinical data and enablement of industry end-to-end data flow Partnered with CDISC, Critical Path Institute, FDA and NCI on CFAST Therapeutic Area Program Steering Committee Asthma, Diabetes, Cardiovascular endpoints, QT studies, Multiple Sclerosis, Hepatitis C and Traumatic Brain Injury selected as first TAs of focus Approved Breast Cancer, Influenza, Lipid-Lowering, COPD, CV Imaging, MDD, RA, Psoriasis & Schizophrenia project proposals SHARE environment (metadata repository) press release issued with CDISC in June 2013; SHARE R1 Release went live Jan 31 2014 Asthma Therapeutic Area User Guide V1.0 published Nov 27 Comparator Drugs for Clinical Trials Establish a supply model to source comparator drugs between companies for use in clinical trials Reduce the cost and effort for comparator drug sourcing Reduce the chance of counterfeit drug in study supply chain Share critical data – like solid dose ambient temp excursions Determined in-scope products and required documentation for distribution model Defined principles and process for drug distribution model MSA's between members finalized First set of transactions initiated in July 2013 Press release issued in August 2013 Multiple transactions continue to occur and direct benefits being realized Expansion of network activities for 2014 Ongoing Initiatives – progress (1 of 3) 14
Five Selected Areas of Focus Have the Shared Goals of Increased Quality, Patient Safety and Accelerated Development Timelines InitiativeObjectiveBenefitProgress to date Model Approach for High-Quality, Risk-Based Monitoring Develop an industry framework for targeted, risk based clinical trial monitoring Improvement in data quality and patient safety for clinical trials Reduction in effort expended on low- value activities FDA and EMA feedback incorporated Position paper and methodology published in May 2013 for access to entire clinical trial community; Update to the paper and associated training materials published in January 2014 More than 30 pilots identified and launched with 8 of these reviewed by FDA prior to initiation Over 2000 unique downloads of position paper Conducted FDA orientation for the TransCelerate RBM methodology Shared Site Qualification and Training Mutual recognition of GCP training between pharmaceutical companies and streamlining site qualification process Improved quality of clinical sites and accelerated study start-up times Reduce site burden Team formed to streamline site documentation Establishment of framework for mutual recognition of GCP training completed Minimum content elements Process for awarding certificates Process for training providers to self attest to minimum criteria/courses Mutual recognition framework established Created and published to TransCelerate website: CV and Site Profile Documents and Guidance Guidance for completion of FDA document 1571/72 Guidance and Delegation of Responsibility form Planning for PI Oversight Training and Training for Sites Less Experienced with Clinical Trials Ongoing Initiatives – progress (2 of 3) 15
Five Selected Areas of Focus Have the Shared Goals of Increased Quality, Patient Safety and Accelerated Development Timelines InitiativeObjectiveBenefitProgress to date Shared Site Collaboration Platform (formerly Common Investigator Site Portal) Establish a single, intuitive interface for investigators, regulators and member companies Ease of use and harmonized retrieval of content and services for investigators Reduce site burden Reduce member company costs Defined components to leverage from existing industry portals Board approval for analysis phase in June Systems integrator, product partner and hosting partner selected Early adopters of system confirmed Ongoing Initiatives – progress (3 of 3) 16
Current State Disconnected interfaces Manual processes and interventions Limited standardized processes Lot of customization Rework Variable quality Wait time Missing information High costs Long cycle times Duplication of efforts Future State Patient-centric clinical trial design End-to-end electronic data flow Seamless interfaces Automated Transparent Increased standardized processes Less rework Quality by design Shorter cycle times Cost efficient Integration of Regulatory, Safety and Medical Sciences Elimination of redundancies Conducting clinical trials together "Colossal Data Analytics" Approved TransCelerate projects The future - a roadmap was created with the future state in mind Ongoing projects Data Standards Risk Based Monitoring Comparator Network (ES) Site Qualification and Training (ES) Collaborative Technology Platform New projects for 2014 Data Transparency/CSR Redaction * Common Protocol Template Investigator Registry Clinical Trial Networks Pediatric patients Minority patients Exploratory projects for 2014 Exploratory project I Exploratory project II Exploratory project III (ES) – Expanded Scope for 2014 * Workstream initiated to meet compliance deadline 17
Three New Initiatives Will Further Support the Goals of Increased Quality, Patient Safety and Accelerated Development Timelines InitiativeUnmet NeedDescriptionBenefit Common Protocol Template Format of study protocols vary from company to company making interpretation difficult for study sites, IRBs, and regulators. Study protocols have become increasingly complex as no agreed upon standards exists driving up cost and time. Manual set-up of clinical systems based on non- standard "manual" protocols are time consuming, costly, and prone to error Standardize the format of clinical protocols to ease interpretation & enable down- stream automation of many clinical processes. Develop industry-wide & regulator accepted standards for required protocol endpoints Higher productivity of sponsors, sites, IRBs, and regulators Less costly and time consuming clinical trials Enabler for downstream automated setup of clinical and operational systems & disclosure activities New Initiatives (1 of 2)
Three New Initiatives Will Further Support the Goals of Increased Quality, Patient Safety and Accelerated Development Timelines InitiativeUnmet NeedDescriptionBenefit Investigator Registry Sponsors invest significant time and money in identifying qualified investigators and setting up study sites To create a shared repository of investigators to support targeted patient selection Reduced cost and time of setting-up and running clinical trials Special Populations Clinical Trial Networks (minority & pediatrics) Qualified investigators with adequate study patients are difficult to find for special populations – e.g. pediatric and minority Studies in minorities and pediatrics are costly and lengthy Efforts are put into repeatedly establishing a network for a single study only to disperse the network after study completion Lead the development of global investigator networks for pediatric and minority populations including governance, investigator and patient registries, and technical infrastructure Faster development of new drugs in both pediatric and minority populations Reduced costs of pediatric and minority trials New Initiatives (2 of 2)
Drug Development is facing a productivity crisis TransCelerate BioPharma Inc. has been founded to address aspects of this issue A number of critical initiatives are ongoing or will start to improve the clinical trial process in key areas Summary 20
Outline TransCelerate Overview CFAST Overview –Therapeutic Area Data Standards Organization –TA Data Standards Projects Opportunity for Collaboration –BRIDG: The Biomedical Research Integrated Domain Group (BRIDG) Model –SHARE: The CDISC Shared Health And Clinical Research Electronic Library (CDISC SHARE) 21
22 CFAST - an initiative to accelerate clinical research and medical product development by creating and maintaining data standards, tools and methods for conducting research in therapeutic areas that are important to public health An Objective - Identify common standards for representing clinical data for studies of drug products in specific, prioritized therapeutic areas [TA] To be implemented using CDISC structures (CDASH, SDTM) Support integration of clinical data from disparate sources as a foundation for end-to-end data flow Coalition For Accelerating Standards & Therapies -- CFAST
Project Organization Project Manager Therapeutic Area Clinical Experts Therapeutic Area Clinical Experts Statistical Analysis Experts Concept Creators CDISC Team Liaisons CDISC Team Liaisons Program Manager Process Expert Consultant Technical Writer SDTM Expert Consultant Terminology Expert Consultants BRIDG Expert Consultants CDASH Team SDS Team Other CDISC Teams Other CDISC Teams ADaM Team Terminology Teams Questionnaires Team Questionnaires Team Review Community: CDISC, C-Path, FDA, TransCelerate BioPharma, Key Opinion Leaders, Medical Associations, U.S. National Institutes of Health, Innovative Medicines Initiative CFAST Scientific Advisory Committee CDISC Chief Technology Officer CDISC Chief Technology Officer CFAST Therapeutic Standards Steering Committee CFAST Therapeutic Standards Steering Committee CDISC Standards Review Council CDISC Standards Review Council Collaborates CFAST Governance CDISC Teams Program Resource Project Resource 23
CFAST TA Data Standards Development 2013 List of Projects 1.Asthma v1.0 - completed Nov 2013 2.Alzheimer's Disease v2.0 – completed Dec 2013 3.Multiple Sclerosis 4.Diabetes in adults 5.Cardiovascular Endpoints 6.QT Studies 7.Traumatic Brain Injury 8.Virology – Hepatitis C 24
CFAST TA Data Standards Development 2014 Partial List of Projects 1.Oncology – Breast Cancer 2.Schizophrenia 3.Influenza 4.Lipid-Lowering 5.Rheumatoid Arthritis 6.Major Depressive Disorder (MDD) 7.Cardiovascular Imaging (echo) 8.COPD 9.tbd 10.tbd 11.tbd 12.tbd See http://www.cdisc.org/therapeutic for more informationhttp://www.cdisc.org/therapeutic 25
Mindmap/model of disease area clinical concepts Essential core data elements with definitions, data types (simple & ISO 21090), BRIDG and SDTM mappings SDTM domains and examples Minimum value sets (code lists) with definitions and c-codes User/Implementation Guide with permissions statement Standard CDASH CRFs with SDTM annotations, as appropriate ADaM Analysis model examples as available Possibly study design models TA Standards: Baseline Content 26
Outline TransCelerate Overview CFAST Overview Opportunity for Collaboration 27
Click to edit Master title style What are opportunities for collaboration ? 28
Clinical Data Standards David Jordan email@example.com firstname.lastname@example.com Rhonda Facile ( CDISC) email@example.com@cdisc.org Comparator Drugs for Clinical Trials - Terry Walsh email@example.com firstname.lastname@example.com Risk Based Monitoring - Reb Tayyabkhan firstname.lastname@example.com email@example.com Shared Site Qualification and Training Sue McHale firstname.lastname@example.com email@example.com Katarina Hugeneck email@example.com firstname.lastname@example.com Shared Site Collaboration Platform - Jackie Kent email@example.com firstname.lastname@example.com Common Protocol Template - Rob DiCicco email@example.com email@example.com Investigator Registry - Bill Jordan firstname.lastname@example.com firstname.lastname@example.com Special Populations Clinical Trial Networks - Susannah Hammond email@example.com email@example.com Contact Points within TransCelerate 29
Adapted from Scott Getzin Safety Standards Domains Topics Collected (CDASH) Observed (SDTM) Analysis (ADaM) Reporting (TFL) Adverse Events i/p Comments n/a Concomitant Medications ?i/p Deaths (AE) ?i/p Demographics ?i/p Disposition ?i/p ECG Test Results ?dft Exposure n/a Hepatotoxicity (central lab) n/a ?i/p Laboratory Data ?dft Medical History ?i/p Pharmacokinetics (lab, exposure?) ?i/p Subject Visits n/a Vital Signs ?dft i/p = In progress n/a = Not applicable dft = Drafted = completed ? = not sure who / status CDISC, PhUSE 30
Therapeutic Area Standards (Defined) Topics Observed (SDTM) Analysis (ADaM) Reporting (TFL) Alzheimer's Disease v1 ?? Pain v1 ?? Parkinson's Disease v1 ?? Polycystic Kidney Disease v1 ?? Tuberculosis v1 ?? Virology v1 ?? Asthma v1 -? Alzheimer's Disease v2.0 ?? Multiple Sclerosis i/p?? Diabetes in adults i/p Cardiovascular Endpoints i/p?? QT studies i/p ? Hepatitis Ci/p ? Etc., Etc.i/p?? Adapted from Scott Getzin 31
Alignment of Clinical Data Flow Data Collection Systems Observed Datasets Analysis Datasets Tables, Figures and Listings Clinical Data Flow Trial Design PRM SDTMADaM No/Few TFL Stds Exist Industry Standards Alignment CDASH ? Courtesy of Scott Getzin 32
Questions? 33
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Uganda Vote Count Starts as Museveni Looks to Extend Ruleby and
Tally begins after some polling delays, social-media blocking
Opposition candidate briefly detained by police, party says
Uganda shut down some social media and briefly detained the main opposition candidate as counting began for an election in which President Yoweri Museveni will probably extend his three-decade rule.
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Museveni's re-election bid shows a rising trend in Africa, where a growing number of leaders are trying to extend their rule, in some cases amending the constitution to do so. Uganda's $27 billion economy has companies such as London-based Tullow Oil Plc and France's Total SA developing its estimated 6.5 billion barrels of oil resources. Uganda's army contribute troops for the African Union campaign fighting al-Qaeda-linked militants in Somalia and backed South Sudan's government in that country's civil war.
Vote Credibility
New York-based Human Rights Watch has warned that police brutality against government opponents risks undermining the vote's credibility. Amnesty International has urged the disbanding of a civilian anti-crime force affiliated with the ruling party, which could number 1 million and whose members have allegedly carried out brutal assaults. Uganda's electoral body on Wednesday accused opposition groups of trying to form illegal militias.
Besigye, who has lost three previous elections to Museveni, has complained of intimidation and said the vote won't be free and fair, raising the prospect of unrest in the aftermath. Security forces teargassed his supporters in the center of Kampala on Monday. Police said one person died in scuffles. The electoral commission, which is using a new biometric system to register voters, has pledged to oversee credible polls.
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Debian: 14 Seconds to Boot
An article from the Debian-Administration.org community describes how to boot up Debian much faster on an Asus Eee 901. Its author, Phil Endecott, claims to do it within 14 seconds using his method.
Endecott is still far from the record of five seconds set by his role models Arjan van den Ven and Auke Kok (video here). The two Intel developers had started the same device under Fedora and Linux Moblin at September's Plumbers Conference. Even so, Endecott presented a number of programs and measures to significantly speed up the Debian bootup process. Some of them are specific to the Asus Eee, but others are transferable to other Linux systems.
Work begins with diagnosing the ist status with help from Bootchart (available as a Debian package) or Bootgraph. The result: from Grub to opening the xdm login dialog takes 33 seconds.
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Kernel tuning is the next step at speeding things up. Here a kernel lacking initrd or initramfs and with compiled hardware drivers comes into play so as to eliminate the time sink of loading kernel modules. The article also alludes to some brand-named kernel patches that are supposed to save time, among them a patch from Arjan van den Ven.
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Endecott's article goes into much greater detail, including configuration data, scripts and boot diagrams to download. He hopes that Debian developers might pick up on some of these tuning tips, possibly enhancing them and including them in distros. He hopes also to satisfy users who don't have kernel experience or other access to the innards of the system.
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What makes hourly workers happy?
Talented Apps
Workforce Institute recently published a whitepaper laying out the impact a Workforce Management system can have on empowering and motivating employees. The paper argues that engagement increases due to things like swapping shifts, working flexible hours, and requesting time off. These things all sound important, but what does an hourly worker really care about? Working enough hours to pay their bills. Can workforce management systems help with that? Absolutely
Best of Horses '08. the funny ones
Phil Fersht
Need to take the edge off that New Year hangover? Help is at hand - here are the stupidest Horses posts of 2008: And if a sourcing advisor was elected President. Bendium Cost-cutting measures for troubled companies in these tough economic times What's driving your outsourcing agenda? The 2008 Horses.
Job Board Coupons… What Next?
Talent Buzz
I never thought I'd live to see the day where job boards would publish coupons. That's the case with the latest coupon book from SHRM and Job Target, containing over 1,000 coupons for job boards. If Recruiters have time in a down economy to clip coupons - "Houston, we have a problem … With unemployment skyrocketing, and current [.].
How Not to do Multimedia Marketing
Staffing Talk
Having screwed it up more times than I can count, I can attest that getting self-hosted video clips to run reliably off your website for a mass audience is no easy task which is why in a pinch I'll always turn to posting on youtube. Microsoft can't get it right either, and this has been going on for years. Microsoft.com freezes if you try to play Ballmer's keynote: Youtube plays it just fine
Specialists, Generalists & 10,000 hours
Talented Apps
There is a growing trend to segment career development practices into two focuses: specialists and generalists. Specialists are individuals with expertise in a particular area. The goal is to develop them to be the very best at what they do. Training is targeted toward specialized skills and, possibly, certifications. Managerial responsibilities are usually not part of the equation, though mentoring is often an important part of the program. Generalists are individuals with broad capabilities that are on a leadership path. Increased managerial responsibility is a critical part of the program.
Another vote for ditching the "O" word
Phil Fersht
Our super-charged discussion on using more relevant terminology to describe global services delivery took on another twist yesterday, when the WSJ published yet another piece about how the outsourcing market is "taking a hit", citing TPI's large-deal data for 3Q08. This follows on from another recent article from the same.
2009 AIRS Job Board and Recruiting Technology Directory
Talent Buzz
Today AIRS announced the release of their Annual Job Board and Recruiting Technology Directory, which can be downloaded for free. This marks the 5th annual edition. According to AIRS, this is the largest, most up-to-date, and most usable career site and recruiting resource on the market. January 8, 2009 — Job Board Coupons… What Next? (5) November [.].
Facebook Promotion: Get Your Free Tempworks Polo Shirt
Staffing Talk
We're thanking the Tempworks fans on Facebook with a free Tempworks shirt. Staffing Talk readers are welcome to join
Some advice to my job searching friends
Talented Apps
I have noticed a few great pieces of advice lately on do's and don't for job searchers. Now Now I have one to add myself. First a recap. . Gretchen suggests practical things like don't forget to make your contact information visible. . Kris Dunn gives some pro tips for Extreme Job Hunting with a vote in favor of a solid and customized cover letter. Jenn Barnes gives the useful tweet that your photo is not a good idea. Here is my item to add to the pile. . Send me your best two page draft and I'll give you my honest feedback.
Can You Spot the Real Stock Chart?
Staffing Talk
One of the images below is a stock chart of public companies that compete with Tempworks, and the other is an artistic work by Jason Corsello's six-year-old. Can you tell which is which? Follow Jason's post to find out the correct answer
Just Ask Her, Dammit
Staffing Talk
Ok, this is very humbling. About a month ago I started using a service that analyzed the Staffing Talk traffic and I was embarrassed to find out that dozens of boys (presumably) come to my site every week because they go to Google and type in "How to Get a Girl to Dance with You" which is something I wrote about last May. So check it out yourself.
How to Handle a Telemarketer and Enjoy Life More
Staffing Talk
Hat tip: Sirona
Is there room for Ambition AND Balance?
Talented Apps
When I read Malcolm Gladwell's Outliers , I had several self-revelations. Deliberate practice and mindset were among them. But there is another thread that keeps haunting me. Gladwell's definition of success is extreme success (mastery, really) and my cultural legacy values balance. Are these two things at odds with eachother? Is it possible to be a master at something and have "a life ? Gladwell then connects this value system to the agricultural requirements of the American landscape. Thus, in order to cultivate young minds, they must have plenty of time to rest.
Temporary Staffing Down Almost 20% According to the ASA
Staffing Talk
The American Staffing Association index fell to 81 in December from a base index of 100 established in 2006. Their numbers match pretty much what I am seeing which is that the market swooned in traditionally strong October and really hasn't picked back up since. But a lot of it is geographic. Michigan and anything close to it is in the tank, but some areas of the country are doing well
Major Layoff at Vedior to Hit USA
Staffing Talk
Europe is abuzz with news of a major layoff at Vedior. Staffing Talk has confidential information that this will hit the USA as well
The Real Cause of the Great Upcoming Offshoring Crash of 2009
Staffing Talk
If you follow the story out of India this morning, you'll see the seed of what I predict will be known as the great offshoring crash of 2009. No doubt, authorities there will spin the Satyam crash as a one-man Indian Enron, but make no mistake: this will sting every player – investors and western companies dependent on offshore – like a Sambol #5 Hot Curry on a Lake Wobegon palate. The real cause of the offshore crash is that you can't keep a good man down. It's a myth that you can develop and RETAIN a highly skilled labor pool at slave wages in a free society.
Love is to Sex Like Good Writing is to SEO
Staffing Talk
Can you have good sex without love? Love as in " agape ", not the Madonna version. No, we can't. Sexuality offers nothing when separated from its spirituality. Can you have good SEO without good writing? Good writing" here referring to clearly expressed creative thought and not the keyword stuffed version. No, we can't. Lasting SEO can't be faked, can't be separated from the promise and continual commitment we provide to our customers. Yeah you can fake out the search engines for a while, maybe a long while, with a variety of black-hat tactics. But the truth will catch up to you.
Marketing News from Around the Company
Staffing Talk
Enterprise supports Gmail … and other imap email services. Most competitors don't offer integrated email and none that I'm aware of let you pick your email provider. Enterprise has a new check box design Sneak preview of updated website New SEM/SEO Effort Paying Off Eight new leads since Friday. Tempworks UK Website Getting Launched [link] Improved Enterprise Email Marketing on the Way Upcoming release features HTML formatted emails. Great for email marketing
Death of A Salesman: The Remake
Staffing Talk
Do you like buying things from sales people? Why is it that as soon as you see a sales person is in the picture you figure 1) it's too expensive and 2) it's too complicated to buy? Have we reached the tipping point of Arthur Miller's Death of a Salesman? How about an upgrade to Death of All Salesmen? It would not be the Aristotelian tragedy Miller meant it to be. In fact, we'd all jump for joy. Get rid of all the salesmen. Imagine. The Tempworks mission in past years has been to eliminate ALL of the non-revenue generators from staffing companies. The fake developers were the first to go.


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Adobe Photoshop CC 2015 highly-compressed [91 MB] only. This version works exactly as extended version of Photoshop CC 2015 and includes all the necessary functions as well. This is Adobe Photoshop CC 2015 zipped to maximum size and can be extracted quickly. With an intuitive user interface, Adobe Photoshop CC 2015 crack allows to easily create images from scratch, create HD designs for all types of activities, create banners and logo for website design and develop 3D images.
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Open the program, if it shows "Error: 16" – Then just right click on shortcut and select "Run as administrator".
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text: Proper Orthogonal Decomposition (POD) is a useful statistical tool for analyzing the cycle-to-cycle variation of internal combustion engine in-cylinder flow field. Given a set of flow fields (also known as snapshots) recorded over multiple engine cycles, the POD analysis optimally decomposes the snapshots into a series of flow patterns (known as POD modes) and corresponding coefficients of successively maximum flow kinetic energy content. These POD results are therefore strongly dependent on the kinetic energy content of the individual snapshots, which may vary over a wide range. However, there is as yet no algorithm in the literature to define, detect, and then remove outlier snapshots from the data set in a systematic manner to ensure reliable POD results. In this paper, one such outlier detection algorithm is proposed: A snapshot is considered an outlier if it has excessively high kinetic energy content as well as relevance index (a measure of flow pattern similarity) versus a particular POD mode. An analytical expression is derived to relate these two parameters and provide the statistical and physical underpinnings for the outlier detection algorithm. The algorithm is applied to several sets of crank angle-resolved engine in-cylinder flow fields in the middle tumble plane that were obtained experimentally using high-speed particle image velocimetry techniques, and improvements in POD results obtained after the removal of outlier snapshots are discussed.


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Greetings Guest!!Dismiss Notice
In order to combat SPAM on the forums, all users are required to have a minimum of 2 posts before they can submit links in any post or thread.
Buying Armor Buying Excellent Stone Gargoyle Thrower Suit (or Artifact pieces)
Discussion in 'UO Trader's Hall' started by Orich, Apr 15, 2014.


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Does ginger affect 7 months baby... does it causes rashes or any other side effects please help asap
31 Views
Doctor Answers (1) on Rashes on anus
Dr. Harsha
Bangalore | General Physician
Hi there...yes vegetables like ginger, garlic can act as irritants when applied over the skin. Kindly refrain from using such home remedies. Rashes over the anus in a 1 year could be due to candidal intertrigo, diaper dermatitis, acrodermatitis enteropathica, atopic dermatitis. It will need detailed clinical examination. So kindly consult a dermatologist for further evaluation and treatment.
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Top: 'Eve' Top by Stella McCartney
Where can I buy this top, or similar version??
Hi Shelly, You can find the purchase link as well as a similar item directly above, with the heading "Shop This Style".
New comments are currently disabled.
Daisy's black printed shirtdress on Madam Secretary:
'Chrissie' Shirtdress by Diane von Furstenberg at Saks Fifth Avenue, $238.80 (was $398)
Also available at: DvF
Elizabeth's white pleated blouse on Madam Secretary:
Pleated Silk Blouse by Derek Lam at Saks Fifth Avenue, $597 (was $995)
Daisy's red striped shirtdress on Madam Secretary:
'Marian' Striped Silk Shirtdress in Red Black by Altuzarra at Saks Fifth Avenue, $1137 (was $1895)
Daisy's trench coat on Madam Secretary:
Wool Gabardine Trench Coat by Tomas Maier at Net A Porter, $843 (was $1685)
Also available at: Barneys
Elizabeth's floral dress on Madam Secretary:
Floral Print Stretch Silk Dress by Oscar de la Renta at Nordstrom Rack, $569.97 (was $1790)


text:
Selling your products at a national, well-known chain, such as Wal-Mart, could propel your small business into a well-recognized national product. You'll need to meet Wal-Mart's criteria, namely by providing high-quality products and meeting strict deadlines. In addition, you'll need to follow Wal-Mart's relatively easy process for businesses interested in becoming distributors.
Things You'll Need
- UCC membership number
- Supplier evaluation report
Thoroughly review Wal-Mart's distributor requirements. Before submitting your product, visit a Wal-Mart store to familiarize yourself with the types of goods it sells.
Apply for a Uniform Code Council (UCC) membership (see Resources). Distributors must have a UPC bar code prefix to create bar codes. You cannot become a Wal-Mart supplier without a UCC membership number. You will need to include a copy of your UCC GS1 letter with your sample.
Register your business with Dun & Bradstreet (D & B). Then obtain a Supplier Evaluation Report by calling (866) 815-2749.
Submit your products via the Online Product Submission form found on Wal-Mart's website (see Resources).
Become certified through the National Minority Supplier Development Council if you are a minority- or woman-owned company. Wal-Mart will request a copy of your certificate upon acceptance. Also, prepare a copy of your product liability insurance certificate. You will need to present this upon acceptance.
Submit a product sample and a copy of your UCC membership upon request by a Wal-Mart buyer. The buyer will provide you with an address. If your product has a variety of styles or colors, detail that information upon submission. Samples should not exceed 25 pounds or three square feet. If your product exceeds Wal-Mart's shipping specifications, submit paperwork that includes product details and illustrations or photographs. Do not send perishable or live goods unless requested to do so.
Tips & Warnings
- If you are a local distributor who will supply five or fewer Wal-Mart stores, visit the store manager to present your product and obtain an application.
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Evian water is a high-quality brand of bottled water, coming from the glaciers of the Alpine Mountains. As with most brands of...


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The Haitian DJ/producer Michael Brun is mostly famous for his great remix of Axwell feat. Steve Edwards – Watch The Sunrise, and has now together with Derrick Rousseau made this track called Prime. It's going to be released as a free download soon, check it out!
Michael Brun and Derrick Rousseau – Prime (Original Mix) by Michael Brun


text: Theory Men's Natural Zack Ps Shirt In Tanna Last seen for $195 at Theory. See more Theory Shirts. Or subscribe to the latest from Theory. Get notified when it's back… We check over 450 retailers daily. Be the first to know when it comes back in stock. get a back-in-stock-alert


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The project "Pearls in the North Sea Trail" was formally closed at the end of 2010. It was funded under the "Value Creation Programme" from the Directorate for Cultural Heritage, running form 2006 – 2010 with the objective of develop new innovative projects related to cultural heritage. So what came out of it all? The overall lesson learned is that he successful projects has taken local traditions and local cultural heritage as their point of departure. By transforming these through art and make these available trough signed and guided tours new products are created that is interesting both to the local population and tourists.
Your current search results
Search results
Pearls in the North Sea Trail – End of Story?
The Coastal Saga WeeksThe Coastal Saga Weeks (Kystsogevekene) is an annual event for mobilising and visualising the traditional Norwegian coastal culture. The event takes place form mid-August to end September each year. The event hosts around 150 different events scattered along the coast of Hordaland, and attracts 35.000 visitors.
Tourism, leisure and sustainable development on the coast, EURISY event
Project Newsletter no. 8As the project moves on there is a great amount of news! This newsletter captures some of the latest stories for you. There is much, much more information behind this, please contact us if you should like to learn more about any of our activities.
Newsletter no. 9
International Appalachian Trail, new section openedThe IAT from Slieve League in Donegal to Larne in Northern Ireland was opened at the end of August 2013. Cotton Joe an Appalachian Trail vet has already walked it. And then he did the Scottish leg all the way from Strandraer to Cape Wrath.
Søderåsen, Sweden
Coast Alive in Angers
International Appalachian Trail
Coast Alive in the Himalayas


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0 Dodge cars are currently listed in the Hay River area for sale
AutoCatch.com is a comprehensive online solution for buying or selling a new or used Dodge in Hay River. All vehicles are listed for sale by local dealerships and private car sellers. Search for new, used, or certified pre-owned Dodge cars, trucks, and SUVs in Hay River, Northwest Territories.


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What keeps you away from good sleep is a matter of individual concern and something you have to look into in order to be able to lead a healthy life. Sleep disorders can lead to nausea, daytime sleepiness, and fatigue throughout the day. A healthy lifestyle is one of the many measures that one can adopt to be able to get a good night's rest.
What keeps you Away from Good Sleep?
People will tell you all sorts of things about your sleeping habit, and the staggering question is, "how much sleep is enough sleep?".read more
According to a new research taking proper night sleep can save you from cancerread more


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Hi there,
anybody interested in creating a regular activity for our kids with an English teacher? At school they have to study French and German but as far as English is concerned there is not much around as after school activity.Language schools are not impressing me much; kids get bored and they end up learning nothing...Any idea?


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(based on 4 reviews)
Ratings Distribution
5 Stars
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of respondents would recommend this to a friend.
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Reviewed by 4 customers
Displaying reviews 1-4
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(1 of 1 customers found this review helpful)
A bag for all casual needs.
By Penny
from San Diego county
Comments about Ur-Go Bag:
There is a place for everything sunglasses, smart phone, monthly planner, pen,wallet, change pocket, hand sanitizer and wallet. It is so handy because you will know where to look for anything and if you need to search visually just unzip and open it wide and you can see all the inside pockets!
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
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(3 of 3 customers found this review helpful)
Attractive, lightweight, multi-purpose carryall
By Old School Diva
from Delaware
This is an attractive, lightweight carryall to use for travel, exercise or shopping. Many pockets to store necessary items safely. Fabric is easy to sturdy and clean.
(2 of 2 customers found this review helpful)
Ur-Go Bag
By AmysOtters
from Upper Darby, PA
Great bag with lots of pockets
(5 of 5 customers found this review helpful)
My favorite bag!
By Franny
from Ulysses, KS
I have several bags of this type, but NONE of them has as many pockets (15!). This is a great bag for everyday use and also for traveling. The hidden pocket is great for stashing hotel bills, cafe receipts, etc. - and it took me three days to realize it was there. Very well HIDDEN. The silver tone hardware is pretty, and three outside pockets have magnetic closures, and three others outside are secured with zippers. The strap adjusts to the length one finds most comfortable.The price is awesome! I paid much more for the others similar to it, and they don't have nearly as many great features as this one!


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42 CFR Part 440 - SERVICES: GENERAL PROVISIONS
Sec. 1102 of the Social Security Act (42 U.S.C. 1302).
43 FR 45224, Sept. 29, 1978, unless otherwise noted.
Title 42 published on 2015-11-28
The following are ALL rules, proposed rules, and notices (chronologically) published in the Federal Register relating to 42 CFR Part 440 after this date.
Title 42 published on 2015-11-28.
The following are only the Rules published in the Federal Register after the published date of Title 42.
For a complete list of all Rules, Proposed Rules, and Notices view the Rulemaking tab.


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Healey on National Guard's Cyber Capabilities
Breaking Defense quotes Cyber Statecraft Initiative Director Jason Healey on the US National Guard's cyber warfare capabilities:
Every state is authorized to have an eight-soldier Army National Guard network security team, though some Adjutants General didn't even know this option even existed until recently, and they have to find the funding themselves without federal help. The Air National Guard has a range of "network warfare" and "information warfare" squadrons of varying sizes, structures, and skill levels.
Some of these Air Guard units are impressive, said Atlantic Council cyber expert Jason Healey: "[There's] the 262nd Network Warfare Squadron in Seattle (which includes lots of people from Microsoft), [and] the 175th Network Warfare Squadron at Fort Meade is deeply embedded in NSA work."
"But states are increasingly trying to grab cyber mission for more budget, especially as more traditional missions are pared back," Healey went on. "This threatens to poison the whole effort as so many state piranha are trying to feed from the same mission."
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- Oklahoma air support unit trains on advanced combat simulator
- Alaska air guardsmen rescue snowmachiner
- Cyber Risk Wednesday: Hacks, Attacks, and What America Can Do about It
- USS Kidd Completes OMSI with USCG
- Statement By Secretary Jeh C Johnson On The U.S. Coast Guard National Security Cutter Bertholf
This press release is licensed under a Creative Commons Attribution 3.0 Unported License. Read full copyright information here.


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Savage® Arms A22 .22 LR Semi-Auto Rifle
Article # 121389
$319.99 was $399.99
Online Availability: In Stock Online
Order Online Pick up In-Store for free
This item ships FREE to any of our Cabela's Canada locations for pick-up. Learn More
Product Description
Savage® Arms A22 .22 LR Semi-Auto Rifle
• Delayed-blowback action reliably cycles magnum cartridges
• Easily adjustable, clean-breaking AccuTrigger
• Lightweight black synthetic stock and a gloss blued barrel
• 10-round rotary magazine
Savage Arms' A22 .22 LR Semiautomatic Rimfire Rifle eliminates the timing concern that's plagued other semiautomatic rimfire rifles by delivering reliable cycling with a delayed-blowback action specifically designed for high-performance rimfire cartridges. 21" gloss black steel barrel with Weaver-style mounts and a lightweight matte black synthetic stock. Savage AccuTrigger™ is easily adjustable without special tools for the ultimate in customization. Features hard-chromed bolt with oversized bolt-handle and dual-controlled round feed. 10-round rotary magazine. Recoil pad. Cross-bolt safety.
|Barrel Length
|Overall Length
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|1 in 16"
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Danilon Equidos comes in sachets of yellow, odourless granules to add to the food of horses. It has to be prescribed by your vet and is used to treat pain and inflammation associated with osteoarthritis, degenerative joint disease, musculo-skeletal.. Read more
Range includes 2 products
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Fortekor is a medication which can be used on cats or dogs but for different ailments. For dogs it is a heart failure medication and in cats is used to treat kidney failure. Dogs that use the medication may have a significantly increased lifespan.. Read more
Range includes 6 products
from £0.48 to
Frusemide (also called furosamide) is a diuretic used to clear excess fluid from the body. Frusemide is particularly helpful in cases of mild, moderate or severe heart failure. When the heart is not able to pump blood around the body as effectively.. Read more
Range includes 2 products
from £0.03 to
Felimazole is a medication for cats which is used to treat hyperthyroidism. This is a condition which affects mainly older animals and relates to the over-activity of the thyroid gland. The medication controls the amount of hormones released by the.. Read more
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from £0.21 to
Epiphen is the most commonly used medication to control fits in dogs resulting from idiopathic epilepsy in the UK. A dose is given twice daily, usually for the rest of the animal's life. Epiphen can be used alone or in conjunction with other.. Read more
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from £0.14 to
Equipalazone contains 1g of phenylbutazone (bute). It is used in the treatment of musculo-skeletal conditions in horses and ponies. Equipalazone has anti-inflammatory and pain relieving properties so it is useful in the treatment of lameness due to.. Read more
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from £21.14 to
Isaderm Gel (previously called Fuciderm Gel) is a skin gel used to treat infected and itchy skin problems in dogs. Isaderm contains an antibiotic (fusidic acid) and a steroid (betamethasone) which between them can kill infection and relieve itching... Read more
Range includes 2 products
from £9.98 to
Frusecare is the UK veterinary licensed form of frusemide made by Animalcare. It is used to reduce fluid accumulation in the body (oedema and vascular) secondary to heart, kidney and liver problems, or in certain types of injury. Below is the.. Read more
Only £0.04
Frontline Combo is the prescription-only form of Frontline Spot On, the most popular Flea and Tick treatment available. Combo has an extra ingredient which is particularly helpful for flea control if you forget to re-apply Frontline as frequently as.. Read more
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from £14.82 to
Isathal is used in dogs for the topical treatment of conjunctivitis associated with Staphylococcus aureus and in particular the biotype Staphylococcus intermedius. In cats for the topical treatment of conjunctivitis associated with secondary.. Read more
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Frusedale contains the drug frusemide which is used to clear excess fluid from the system. This is prescribed for dogs and cats with mild to severe heart failure, or in some cases of reduced kidney or liver function.It is normally given two or three.. Read more
Only £0.05
Dopram-V is available as a liquid drop to place inside the mouth, or as an injection. The oral dropper is often kept by breeders of dogs, cats, lambs and calves to use after a difficult birth to help stimulate breathing. The active ingredient is.. Read more
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Enurace Tablets are given to bitches which have been spayed (neutered or ovariohysterectomised). Enurace acts to tighten up the muscles near the exit to the bladder and is used to treat urinary incontinence. It has been found that some spayed.. Read more
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Fucithalmic Vet Eye Drops contain an antibiotic to treat conjunctivitis in dogs, cats and rabbits. The tube is held a short distance above the open eye and one drop is allowed to fall onto the eye itself. This quickly spreads within the tear film.. Read more
Dilaterol is used in horses with respiratory problems to help open up the airways and clear mucus which may be accumulating abnormally. It can be used alone or combined with other therapies.
Only £34.75
Enacard tablets are used to treat dogs with mild, moderate or severe heart failure. It has been shown to increase the ability to take exercise as well as life expectancy in affected dogs. It is particularly intended for dogs with leaking valves.. Read more
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ERIC Number: ED297990
Record Type: RIE
Publication Date: 1986
Pages: 212
Abstractor: N/A
Reference Count: N/A
Feminist Approaches to Science. The Athene Series.
Bleier, Ruth, Ed.
This collection of papers explores the nature of contemporary science and attempts to further a view of science that is "different, better, feminist, and emancipating." Most of the papers were presented in their original form at a symposium, Feminist Perspectives on Science, at the University of Wisconsin-Madison, in April, 1985. Included are: (1) "Introduction" (Ruth Bleier); (2) "Science Seen through a Feminist Prism" (Marion Namenwirth); (3) "Critiques of Modern Science: The Relationship of Feminism to Other Radical Epistemologies" (Elizabeth Fee); (4) "Beyond Masculinist Realities: A Feminist Epistemology for the Sciences" (Hilary Rose); (5) "Primatology is Politics by Other Means" (Donna Haraway); (6) "Empathy, Polyandry, and the Myth of the Coy Female" (Sarah Blaffer Hrdy); (7) "Sex Differences Research: Science or Belief?" (Ruth Bleier); (8) "The Relationship between Women's Studies and Women in Science" (Sue V. Rosser); (9) "Taking Feminist Science to the Classroom: Where Do We Go from Here?" (Mariamne H. Whatley); (10) "Further Readings on Feminism and Science" (Susan E. Searing). Brief autobiographical sketches of the editor and contributors are provided in the last section. (CW)
Descriptors: College Science, Females, Feminism, Higher Education, Research, Science and Society, Science Education, Secondary Education, Secondary School Science, Sex Differences, Teaching Methods, Womens Education, Womens Studies
Pergamon Press, Maxwell House, Fairview Park, Elmsford, NY 10523 ($12.50 paperback--IBSN-0-08-032786-9; $27.50 hardcover--ISBN-0-08-032787-7; postage and handling extra unless prepaid by check; allow five weeks for delivery).
Publication Type: Reports - Descriptive; Books; Collected Works - General
Education Level: N/A
Audience: Teachers; Administrators; Researchers; Practitioners
Language: English
Sponsor: N/A
Authoring Institution: N/A
Note: For other publications in this series, see SE 049 619-621.


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The Narrow Gauge Inn: "Great service and atmosphere" Yosemite Restaurant Tip by Jairip
Yosemite Restaurants: 1 reviews and 0 photos
We loved this place. We had two very special dinners there. They're a bit pricey by our standards, $100 w/wine, for two people. But it's a beautiful setting. They have a large Buffalo head mounted above the bar. The bar also has a room behind it with roaring fireplace and several other mounted animal heads. Not a place to take your card carrying PETA friend to. Their food and wine selection was great. We did meat both nights. Actually we were only supposed to have dinner there one night, but it was so good, we blew off the other place and came back. I would go up to Yosemite, just to have diner there.
Check to be sure they're open before you make plans to go. They close early for winter. Last day open when we went was Oct 19th, 2003.
Address: Between Oakhurst and the entrance to the park.
Price Comparison: more expensive than average
Directions: Located right next to the Sugar Pine railroad.
Price: US$41 and up
Rating: 5
Theme: Local
Have you been to Yosemite?Share Your Travels


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Gate Valve, Class 300, 3/4 In., FNPT
MILWAUKEE VALVE| Zoro #: G0718182| Mfr #: 1182 3/4"
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$94.00 /ea
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Technical Specifications
|Zoro #: G0718182 Mfr #: 1182 3/4"
|Handle Material: Malleable Iron
|Standards: MSS-SP-80
|Valve Class: Class 300
|Valve Stem Type: Rising
|Stem Material: Bronze
|Item: Gate Valve
|Max. Working Steam Pressure - WSP: 300 psi
|Wedge Material: Bronze
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|Bonnet Style: Union
|Body Material - Valves: Bronze
|Handle Type: Hand Wheel
|Connection Type: FNPT
|Top of Handle to Inlet Center: 2-1/2"
|Max. Water Pressure - CWP: 1000 psi
|Pipe Size - Valves: 3/4"
|Inlet to Outlet Length: 6-1/4"
|Country of Origin (subject to change): Multiple
Product Description
Gate Valve, Class 300, Size 3/4 In, FNPT Connection, Material of Construction Bronze, Top of Handle to Inlet Center 2.50 In, Inlet to Outlet Length 6.25 In, Rated For 300 PSI SWP 600 PSI WOG, Max Temp 550 F, Rising Stem, Stem Material Bronze, Union Bonnet, Bronze Wedge, Malleable Iron Handwheel, Standards MSS-SP-80


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I love podcasts. I started listening to them back in high school on road trips, long bus rides, while working on mindless tasks, or even during the occasional attempt at working out. The gym habit never stuck1 but the podcast addiction did, and it wasn't long before I was wondering what it would be like to create my own. What would it be about? Well, sex. Obviously. But what specific sexy niche would it fill? Who would be on it? What would it be called?
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2 Beds
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Allan Yn Y Fan is Wales' leading Celtic music band of the 21st Century with an international reputation for their concert, festival and recorded work. The multi-instrumental quintet are now gaining a reputation as much for their "beautiful vocals" as for their "fiery instrumentals". Allan yn y Fan embrace their audiences with both their own beautiful and upbeat tunes and a selection of Wales' most haunting songs and melodies. The band's international touring experience includes performances in France, Germany, Luxembourg and the Czech Republic and many events in the UK.
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President Barack Obama's campaign on Thursday took aim at a recent attack ad released by Karl Rove-backed group Crossroads GPS, calling its claims "B.S."
In a 3-minute-long web video, Obama deputy campaign manager Stephanie Cutter provides "the facts" to debunk the ad's jabs at what it says are Obama's failed campaign promises.
"Karl Rove's group Crossroads is spending $25 million from secret donors to tear down the president in a new ad," Cutter says. "Time to tear this thing apart."
(Watch above)
As Cutter mentions, the Crossroads ad is part of a $25 million buy that will air in a number of battleground states. It hits the president on his 2008 comments on foreclosures, taxes for the middle class, health care reform and deficit spending.
Cutter argues that the claims are "another set of outright distortions," made worse by the fact that GOP presidential candidate Mitt Romney has a weak record on the highlighted issues. She then encourages viewers to do something about the ad's attacks.
"Karl Rove is relying on you to do nothing to call out his B.S.," she says. "I know you'll prove him wrong."
Crossroads GPS is a 501(c)(4) nonprofit and ally of Rove's American Crossroads super PAC. Last year, it reported that it had raised more than $77 million through contributions from undisclosed donors. While its nonprofit status allows it to keep donors secret, Crossroads reported two gifts of $10 million each and four of more than $4 million.
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Busting the Mob: The United States v. Cosa Nostra by James B. Jacobs (Paperback, 1996)
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About this product
- DescriptionSince Prohibition, the Mafia has captivated the media and, indeed, the American imagination. From Al Capone to John Gotti, organized crime bosses have achieved toriety as anti- heroes in popular culture. In practice, organized crime grew strong and wealthy by supplying illicit goods and services and by obtaining control over labor unions and key industries. Despite, or perhaps because of, its power and high profile, Cosa Nostra faced little opposition from law enforcement. Yet, in the last 15 years, the very foundations of the mob have been shaken, its bosses imprisoned, its profits diminished, and its influence badly weakened. In this vivid and dramatic book, James B. Jacobs, Christopher Panarella, and Jay Worthington document the government's relentless attack on organized crime. The authors present an overview of the forces and events that led in the 1980s to the most successful organized crime control initiatives in American history. Enlisting trial testimony, secretly taped conversations, court documents, and depositions, they document five landmark cases, representing the most important organized crime prosecutions of the modern era--Teamsters Local 560, The Pizza Connection, The Commission, the International Teamsters, and the prosecution of John Gotti.
- Author BiographyJames B. Jacobs, legal scholar and sociologist, is Warren E. Burger Professor of Law and Director, Center for Research in Crime and Justice, NYU School of Law. Among his books are Chris Panarella is a Fellows at Center for Research in Crime and Justice at New York University. Jay Worthington is aFellows at Center for Research in Crime and Justice at New York University.
Key Features
- Author(s)James B. Jacobs
- PublisherNew York University Press
- Date of Publication01/10/1996
- LanguageEnglish
- FormatPaperback
- SubjectSocial Issues, Services & Welfare
Publication Data
- Place of PublicationNew York
- Country of PublicationUnited States
- ImprintNew York University Press
- Content Noteblack & white illustrations
- Weight408 g
- Width3895 mm
- Height5830 mm
- Spine19 mm
Editorial Details
- Format DetailsTrade paperback (US)
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Excess tiredness
I always feel excess tiredness ask over the day. When l wake-up in the morning after one two hour again I feel like sleepy. Please advise.
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Doctor Answers (2) on Excess tiredness
Dr. Shweta Vaibhav Tiwari
10 yrs. of exp | Nagpur | Homeopath
Sir, if you feel sleepy or you feel very tired by any slightest work than please check your haemoglobin it may be one of the cause of your problem. If your haemoglobin will be low than add green leafy vegetables like spinach ,beetroot,carrot etc.
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Dr. Anirudh Agrawal
25 yrs. of exp | Delhi | General Physician
What is your weight ? Do you snore a lot ? Please meet your doctor and rule out Diabetes and Sleep Apnoea.
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