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The White Lady of Stow Lake
A new Catherine Cavendish book always shivers me timbers. She really knows how to hit my paranormal sweet spot. To celebrate the release of her latest and greatest, Saving Grace Devine, I invited Catherine to stop by and give my Hellions some world class goosebumps. So dim the light, settle into a comfy chair and read the tale of the White Lady of Stow Lake…
In my novel, Saving Grace Devine, a young girl is drowned, but her spirit returns to haunt the lakeside where she met her untimely end. She seeks help from the living, to help her cross over to the afterlife.
From my research, it would appear that my fictional Grace is not alone. Many people have reported seeing ghosts of drowned girls and young women, who are apparently bound to the shores of the lake where they died. They all appear to be searching for something, or someone -in dire need of help from the living to help them join the world of spirit.
And not all of them are benign.
One such wraith seems to constitute a deadly reason why I, for one, would think twice before venturing on a walk around Stow Lake in San Francisco's Golden Gate Park. Her appearances have been frequent and well documented.
Golden Gate Park is landscaped on similar lines to New York's Central Park. It hosts a museum, Japanese Tea Gardens, the Conservatory of Flowers, Sprekels Park and, of course, Stow Lake. It also houses a number of ghosts – and even an allegedly moving statue. But more of that later. We're concerned now with "a thin, tall figure in white." So said Arthur Pigeon, as reported in the San Francisco Chronicle of January 6th 1908. Police had pulled him over for speeding and he told the newspaper that it had blocked his way as he drove out of the park, "…it seemed to shine. It had long, fair hair and was barefooted. I did not notice the face. I was too frightened and anxious to get away from the place."
Of course, the temptation is to say the man was merely trying to avoid getting a speeding ticket. And if his had been the only report, then that could well have been the case. But it wasn't. Over the hundred plus years since that Chronicle article, many other people have reported seeing precisely the same apparition.
So who is this mysterious 'white lady' of Stow Lake?
There are, as always, a number of theories. One of the more compelling is that in the late 1800s, a young woman was out, walking her baby in its pram around the lake. She became tired and sat down on a bench. Presently another lady came to join her and the two struck up a conversation. So engrossed was the young mother that she failed to notice the pram rolling away. Suddenly she realized it had gone. There was no sign of either the pram or the baby. Panic stricken, she searched high and low, asking everyone, "Have you seen my baby?" No one had. For the rest of that day, and into the night, she searched.
Finally, she realized the baby and the pram must have fallen into the lake. She jumped in and was never seen alive again.
Witnesses who report seeing her speak of a woman in a dirty white dress, sometimes soaking wet and, contrary to Arthur Pigeon's assertion that she had fair hair, the other reports consistently state she has long, dark hair. Sometimes she is also seen on Strawberry Hill – adjacent to the lake. Her face wears an anxious expression and she has been known to approach people walking around the lake at night. She asks, "Have you seen my baby?"
As for the statue I mentioned earlier, this is called 'Pioneer Woman and Children'. It has a reputation for moving around – and even changing shape. These phenomena always occur at night and seem directly linked to the white lady. Sometimes the statue's face changes. Other times, it has no legs or head. Motorists have reported electrical problems. Different cars driving near the statue or lake at the same time have stalled simultaneously.
Finally, if you are brave – or foolhardy – enough, try going down to Stow Lake at night and say, "White lady, white lady, I have your baby" three times. It is said she will then manifest herself before you and ask you, "Have you seen my baby?" If you say, "yes", she will haunt you ever after. But, if you say, "no", she'll kill you.
Now there's no documented evidence of the white lady committing murder. But are you prepared to put her to the test?
Can the living help the dead…and at what cost?
When Alex Fletcher finds a painting of a drowned girl, she's unnerved. When the girl in the painting opens her eyes, she is terrified. And when the girl appears to her as an apparition and begs her for help, Alex can't refuse.
But as she digs further into Grace's past, she is embroiled in supernatural forces she cannot control, and a timeslip back to 1912 brings her face to face with the man who killed Grace and the demonic spirit of his long-dead mother. With such nightmarish forces stacked against her, Alex's options are few. Somehow she must save Grace, but to do so, she must pay an unimaginable price.
You can find Saving Grace Devine here:
And other online retailers
Other books by Catherine Cavendish include:
And are currently available – or soon will be – from:
Catherine Cavendish Amazon page
Catherine Cavendish lives with a long-suffering husband and 'trainee' black cat in North Wales. Her home is in a building dating back to the mid-18th century, which is haunted by a friendly ghost, who announces her presence by footsteps, switching lights on and strange phenomena involving the washing machine and the TV. Cat has written a number of published horror novellas, short stories, and novels, frequently reflecting her twin loves of history and horror and often containing more than a dash of the dark and Gothic. When not slaving over a hot computer, she enjoys wandering around Neolithic stone circles and visiting old haunted houses.
You can connect with Cat here:
Catherine Cavendish
It's Time For Bloody Good Horror! An Interview with Casey Crisswell
Like so many people, I'm a podcast junkie. I have a handful of podcasts that I absolutely must listen to each and every week. One of them is Bloody Good Horror, a horror movie review podcast that is very much like hanging out with friends at a bar. They're currently at 400 episodes and counting. That's a crap ton of horror movies!
Today I present to you Casey Crisswell of the BGH OG crew. For once, he can talk without Eric, Joe, Jon or Mark interrupting him. 😉 Take it away Casey…
Casey, you're one of the Fab 5 of the Bloody Good Horror Podcast. Congratulations on episode 400. That's a monumental achievement. How did you get started with BGH, the best horror movie review podcast on the planet?
My involvement with BGH is completely the fault of Night of the Living Podcast!
Some years ago, I set out to be a writer and did the typical struggle of 'what the hell am I going to write about?'. After lots of digging around online and lots of forum posts stating 'write what you know', I started thinking about what I did in fact know. The first thing that came to mind was I love cheesy horror flicks, so I started out with that on my old blog CinemaFromage.com.
After about a year of that, I was listening to a episode of NOTLP one day and they talked about a new sponsor they had at the time, Eric from Bloody Good Horror and talked about he was looking for writers. BGH had existed with Eric and Mark years before, then went on hiatus and they were coming back. I reached out, Eric called me and we shot the shit for an hour or two one night talking about horror flicks, and the rest is history I suppose!
Podcasting is such a labor of love, especially for folks like you who were there in the pioneer days. Were there ever times when you questioned your sanity and just wanted to call it a day? I'm sure having a support system in the other guys (and now lasses) helped a lot.
It can be a hard road starting out, and it's a lot like starting out with writing as well. In the beginning, it feels like you're podcasting to the void. It's a long time before you're going to get any meaningful feedback on what you're doing and as a creative type, that can be really hard to deal with.
Lucky for us, when we started Eric, Mark, Jon and myself had hit off well and we kept pretty regular conversations going about the topic via email. All of us had different parts of the web we liked to dig around in so we were able to spread some of that hard to find feedback around which helped. Thankfully for us, in the way that we mostly strangers hit it off early on, we were able to keep each other pretty excited and down to earth when problems popped up. I'd say it's important to state that we concentrated on the site pretty exclusively before we decided to work on the podcast, so we already had some time together under our belts before we tackled the great audio beast.
I find that your movie reviews are a lot like my own. We tend to go a little easy on some of the less than stellar flicks. What are some movies that are so bad, they're good?
I love a lot of cheese in my flicks! I am probably one of the most forgiving critics out there. For me, especially in the low budget film arena, I can look past a lot of technical problems and judge a movie on how much fun I had watching it. One that stands out for me is one I covered on the Cinema Fromage podcast called "The Majorettes". At first glance, it's a pretty generic 'hooded psycho murders high school girls' flick from the 80's. When they wind up going places you'd never imagine from the basic premise, it's just fun to see how far the film makers imaginations went with it all!
Okay, we need to talk about some assertiveness training. Eric and the gang sometimes barely let you get a word in. And you have some real insightful shit to say. What's the haps?
Ha, yes, some assertiveness training would do well for me! I'm a team player and a 'don't rock the boat' kind of guy. Which is fine for the most part. When you're dealing with other more dominant personalities, it's easier to get run over!
But that's why I like running my spin-off shows. I get to do whatever the hell I want!
Thankfully, with this crew when it gets a little over bearing and I don't get more than five words in an episode, I can generally say, "Dudes, what the hell?" and it gets sorted out pretty quick.
What's something about you and the BGH crew that the general public may not know about? It's time to spill some beans!
Mark really is a beaver! And Jon's a Democrat!
Other than that, we're pretty up front on who we are. What you hear on the show is what you're going to find if you hang with us at a horror convention. Just a lot drunker!
If you had to be trapped on an island for 10 years with one member of the BGH team, including the new class, who would it be and why? By the way, on this island, there's a waterfall that flows with lager instead of water.
I'd probably go with CC. The biggest problem with life on a deserted island is boredom, and CC knows lots of cool shit that I normally don't know much about, so we could talk about some awesome stuff!
You're also a writer (often introduced by Eric as 'a writer of horror fiction'). You've published two short stories, Jackboots for Jesus and Deep Lies the Murky Floor (great titles and fun reads). Any plans for future stories or better yet, a full novel?
It's funny; over the past fear years I've often kind of groaned whenever Eric introduced me as such. I did definitely dabble for awhile there, but I hit a bad spot of depression and lack of confidence a few years ago and kind of gave up for a bit. Wasn't proud of it, but wasn't getting healthier as the rejection slips piled up and the love of it faded for me.
But, that's all behind me now and I'm slowly working my way back to living up to the title. I've got some more short stories in the works, and I'm diving into the writing world with a different attitude and a bit of a new angle this time around.
I can tell you there's some bigfoot stories on the burner, maybe a necromancer story. Maybe even some non-horror stuff as well! There's also some definitely plans and ideas for a novel or two out there as well, but that will be down the road as I start to knock the rust off and working back into the groove. There's even some ideas for non-fiction work as well, such as some old collections of Cinema Fromage articles from back in the day, maybe even a memoir on how one becomes a geeked out middle aged man obsessed with horror flicks! We'll see!
What book do you think would make a great movie, and what movie that was a book should be erased from the collective conscious?
This is a pretty tough question to be honest! I'm a big reader and there is a TON of stuff from a lot of genre's I'd love to see get made. I'm a big Sci-Fi reader and I've been dying to see a film version of Joe Haldeman's "Forever War" for…forever. (Yes, I went there.) There's been lots of hints and almost's but still haven't seen it all come together. On the fantasy side, I've long been a huge fan of Glenn Cook's "Black Company" series, and I think that would be fun to see on the screen as well. Plus, those guys were all pretty grimy and would fit in perfectly in today's "Game of Thrones" world. As for horror, there's a few that come to mind. I got really excited for the talk of Guillermo Del Torro's "At the Mountains of Madness", but at the same time I worry they'd never do it justice. I think Joe Hill's "Heart Shaped Box" would be great too. That book gave me anxiety!
As for the opposite, I've already stated I'm pretty forgiving but man, we could do without "I Am Legend" from 2007. It was such a disappointment. Especially since we already knew the formula could be great with "The Omega Man" and "Last Man on Earth"!
You're also the host of another podcast, Cinema Fromage. Tell folks about the deeper exploration of less mainstream movies you cover on the show. Thanks to you, I watched Short Term 12 and was blown away. It's also where I fell in love with Brie Larson.
I actually have two side podcasts, Cinema Fromage as well as The Instomatic, which is where you would have heard about Short Term 12! Both shows are currently on hiatus, but they're gearing back up for a new return, probably with a bit of a twist on their original format.
For me, I love digging around through the movie landscape to find the diamond in the rough. I usually try to find at least one thing I like about any movie I happen to be watching. Be it acting, writing, camera work, whatever. No matter how low budget or off kilter a flick is, these people put in a lot of work to get this vision out there. Their movie may have problems, but we don't need to shit on them completely, right?
Regardless, one of my favorite things about being a horror nerd growing up was the hunt for something weird. I grew up in a small Indiana town that had two video stores and not much else. As I started to find other like minded friends that were into horror flicks, we started gathering and holding on to what we could find. Fangoria magazines, HBO Bootlegs, the works. Back then, (early 80's), you had to work to find that weird cool thing that surprised you and knocked your socks off. It just wasn't always available to you. Some times, it might take you two to three years to find some flick you read about in Fangoria one evening.
These days, that element is gone. I won't like; I love having millions of movies at my fingertips at a moments notice! But, that feeling of 'the hunt' isn't there anymore. It's so easy. So some times, it's fun to go fishing in the depths of the weird and obscure so you get that emotional payoff to find something awesome.
After all, these days we can pretty much guess how any Hollywood blockbuster is going to play out, right? It's fun to be surprised!
Time for some quick hits:
Favorite BGH episode?
Tough choice. Probably the My Soul to Take episode, that flick was just ponderously bad!
Least favorite BGH episode?
The infamous Prom Night episode where Eric and Jon almost came to blows. It's not fun to watch mom and dad fight.
Preferred beverage to imbibe while recording?
Depends on the mood. Generally beer, whichever's in the beer fridge.
Finish this – Vape is…
First horror movie that scared the crap out of you.
Favorite horror con?
HorrorHound, easy. I've met some of the greatest people at that show!
Your thoughts on nudity in horror movies. Should it be mandatory?
Mandatory? Nah. But, I'm not a prude either! If it fits and everybody's comfortable with it, go for it.
What can we all expect from BGH in 2017 and where can everyone find you to listen to your podcast, catch up on reviews, order some killer swag or become a patron?
2017 should be a good year around the BGH parts. We'll be adding more writers, more content and beefing up the spin-off casts in the next year. Thanks to the awesome support we get from our listeners through Patreon, we have a pretty great opportunity to do some great stuff coming up.
You can find us at http://www.bloodygoodhorror.com. You'll find daily reviews and all of our podcast content from the main show and the spin-offs! Also, if you're ever not sure what you want to watch, try our new web toy Mark the Web Beaver built, http://www.killer-flix.com! You can find links to our t-shirts and Patreon info there as well, or head over to http://www.patreon.com/bloodygoodhorror to find out how you can get access to our 350 back episodes and more goodies!
As for me, keep an eye on http://www.cinemafromage.com. It's not much at the moment, but there's some stuff in the works!
Best Horror Movies of 2016
2016 may not have been a year chock full of future classic horror flicks, but there were some real standouts. I had a bigger list than usual to choose from, but once I got past my top 5, the rest were pretty interchangeable as far as jockeying for position. March was a banner month for quality horror releases. October never seems to be. Strange.
So, without further ado, here is my annual top 13 list for the year. Hopefully this will give you something to watch on these cold January nights.
This was one of the first horror movies I watched in a theater last year. I was bored and figured it would kill some time. It makes my list because of the strong performance by Lauren Cohan and the overall creepiness of the doll, Brahms. Just look at that face. *shudders* With a very cool twist, The Boy is definitely worth a watch. Plus you'll want to have a son and name him Brahms, just for the sake of saying his name over and over again.
Look, I know that this movie has as much to do with the real Enfield haunting as I do with ending World War II. That being said, it was fun in a well made, house of horrors kind of way. There were some good jump scares and that nun haunts my dreams. Plus, I'll watch anything with Vera Farmiga (and if you haven't been watching her in Bates Motel, shame on you!).
I've come to realize that The Purge is one of the most solid horror franchises to come along in many years. For my money, it gets better with each movie. Election Year is just bat shit crazy with some of the wildest visuals of the series. I fell in love with the 'car of lights' and masked hotties out for a night of murder. Might be my next tattoo. It's a wild ride and I demand a fourth flick!
Don't let the 2 1/2 hour running time scare you off. The Wailing is a disturbing, engrossing trip into witch doctory and possession. A product from Korea, it has the most stunning imagery of the year, with scenery to die for. Add to that several scenes that will make your blood run cold, and you have a winner.
The premise is deceptively simple – a deaf woman is trapped in her remote house, stalked by a masked (at least for a while) killer. I didn't realize how tense I was until it ended and I felt stabbing pain in my jaw. Being deaf, she can't hear her attacker as he prowls around the house, nor can she hear the noise she makes as she tries to get away. Good home invasion horror.
This is why you don't accept a dinner invitation to your ex-wife's house! You know right away that something is up with this gathering of old and new friends in the Hollywood hills, but it's a blast watching it all unfold. The ending left my mouth hanging wide open. Best watched with sketchy friends.
Now, I know a lot of folks were calling this the best horror movie to come along in years. It's not, but it is a lot of twisted fun, especially thanks to Stephen Lang's killer portrayal of a blind man trying to fend off a trio of burglars. This is the second movie of note to be set in the ruins of Detroit (the first being my favorite, It Follows). The abandoned neighborhood alone gave me the willies. There is one scene that will linger with you. I won't spoil it, but don't watch it after you've eaten turkey.
A young couple moves into a house owned by the strangest looking and sounding dude since the wackadoo from The Human Centipede 2. What could go wrong? Disturbing owner installs cameras all around the house and sees things he should not see. I LOVED the way this one ended. If you're a fan of The Loved Ones, the vibe this flick gives off is just for you.
Hands down, the creepiest movie of the year. Colonists are thrown out of town and forced to struggle to survive in the wilderness. Right off the bat, a witch steals their baby and it's all downhill from there. This movie has it all – creepy twins, bitter cold and darkness, the devil and Black Phillip the goat. Do not miss this one.
No one should be surprised that a guy who calls himself a monster man would be over the moon about a movie called The Monster. The real horror here is the relationship between an alcoholic mother and her young daughter. Trapped on a dark, rainy road in the dead of night, they have to battle a terrifying creature that is the physical embodiment of mom's karma. With two stellar performances, it's sometimes hard to watch and pretty bleak. All the ingredients I look for!
This is the first Turkish movie to ever make my list. It's a true WTF flick. It makes Hellraiser look like a kid's cartoon. It's gross, disturbing and maybe doesn't make a ton of sense, but it's a freaking blast. If this is what hell is like, I'm going to church every day.
Look, I'm sick to death of all things zombie, which just goes to show how great this movie is. It's a Korean zombies on a train and easily the best zombie flick since the original Day of the Dead. I love the way the zombies reanimate here and pile up on one another. It's the only movie I've watched in years that had me shouting out loud. Get your ticket for this train. You won't regret it.
The moment I saw this in the spring, I knew it would be my favorite movie of the year. John Goodman is menacing and simply awesome as a doomsday prepper who 'saves' a man and woman from a supposed alien invasion above. This is vastly different from Cloverfield, and for my taste, far better. I almost didn't want to leave the bomb shelter. It's the only movie that came out in 2016 that I bought so I can watch it over and over.
And now, for some honorable mentions…
Like I said, once I got past my top 5, quiet a few movies on my longer list could have cracked the top 13. Here are some others that tickled my horror bone : LIGHTS OUT, THE AUTOPSY OF JANE DOE, and I AM THE PRETTY THING THAT LIVES IN THE HOUSE.
What were your favorite movies of 2016? What movie do you think I'm crazy for including or excluding? Lay it on me!
VIDEO VISIONS – A Look Back At The 80s Horror Scene
As a devout reader of Cemetery Dance Magazine since the early 90s, I still can't believe I now have a monthly column on their online mag. VIDEO VISIONS is a look back at what it was like growing up a horror hound in the 80s, the golden age of horror.
I start things off with a little tale of the first movie my father rented when he bought the family's original gangsta VCR – VIDEODROME. Little did he know how much it would change the lives of both his children in profoundly different ways.I hope you take the trip back in time with me each month. Hopefully it brings a smile to your face and a shiver down your spine.
So, what was the first horror movie you ever watched on your VCR?
Cover Reveal : WE ARE ALWAYS WATCHING
I'm beyond excited to not only share the brilliant cover art for my upcoming novel with Sinister Grin, but also show you the progression of the art and how it came to be in artist Zach McCain's own words! WE ARE ALWAYS WATCHING is a chilling tale of isolation and deep, dark family secrets set on a withering Pennsylvania farm. Here's the official Sinister Grin press release and a rare behind the scenes peek into how book covers are born.
Last month, Sinister Grin Press was very excited to announce our publishing deal with the best selling and fan favorite author Hunter Shea. This is the first time Sinister will publish work by Shea, and as well, we are honored to publish his first limited edition! In January 2017, we'll start the year off in horrific style by making WE ARE ALWAYS WATCHING available in a hardcover Limited Collector's Edition. We'll be offering the paperback and e-book versions a few months later.
Today we are anxious to reveal the cover for WE ARE ALWAYS WATCHING by Hunter Shea, with art and design by the amazing Zach McCain!
Here are some of Zach's thoughts on his artistic progression and thoughts when making the cover…..
The direction I got for this cover was very simple and straightforward: A run down farmhouse with a yard overgrown with weeds and the shadow of a person stretching out towards the house. At first I didn't think there was much I could with this and it reminded me of many covers I had seen from small press horror publishers years ago.
I started drawing the house straight on and large on the page. Something about this started to look boring to me and I found myself struggling to continue.
At this point I decided to start completely over. This time I would draw the house from an angle and looking slightly up at it. And I decided to make it much smaller.
I felt much better about it after making the changes and quickly finished the pencil drawing portion of the cover.
I was still concerned about it looking like so many other similar covers that I had seen of a spooky house so I decided to give it a harder edge. More "Texas Chainsaw" and less "Haunted Hill."
The final step was adding the text. It ended up being way better than I had originally expected it would. I've found that if you aren't "feeling it" then it is better to scrap it and start completely over than to continue with something that you aren't confident with.
Thanks, Zach!
At Sinister Grin Press, we love how it turned out. Watch for more news to come on ordering the limited edition from our website. And as always, we welcome your visit to our site and your patronage. We hope to make 2017 our best year yet and continue to produce quality "horror that'll carve a smile on your face."
Interview with UFO Researcher and Author Ryan Sprague
For anyone who follows current trends in the UFO field, the name Ryan Sprague has been as ubiquitous as the phrase, 'the truth is out there'. You can hear him on his podcast, Into the Fray, as well as a guest on just about every UFO/Paranormal podcast out there. You may have also seen him on TV on the Travel Channel, Science Channel and more. A New York playwright, he's also the proud author of Somewhere in the Skies: A Human Approach to an Alien Phenomenon. I recently sat down with Ryan to talk about his book, the possible truth behind the UFO phenomenon and where to get the best hot dogs in New York.
Tell us about your path from accomplished playwright to author of Somewhere in the Skies : A Human Approach to an Alien Phenomenon and podcaster on Into the Fray Radio. If life is all about experience and diversification, you're doing it right.
Well, I don't know if I'm doing it right, but I am definitely trying to do it! And if people want to follow me on that journey, I couldn't be happier and more appreciative of that. My stage and film writing began in college at Oswego State University (Where snow would reach my neck during most winters, and ropes were put between buildings to pull your way to class… no joke). My main focus was theater, but I just happened to take one playwriting course my sophomore year and I was hooked. I then dove head first into playwriting, and have since made that my main focus here in New York City where I've been living for the past ten years. I was also always fascinated by the UFO topic, having had a rather dramatic triangular UFO sighting over the Saint Lawrence River in Upstate NY when I was twelve years old. I started writing for several alternative print magazines about UFOs, and even began work on a stage play about the 1980 Rendlesham Forest UFO incident. I finally decided that I wanted to write a book and really get my own voice and thoughts on the the topic out there, and that's how the book came about. After two years of research, it's finally out on the shelves and I couldn't be happier. As for Into the Fray, I am an avid podcast listener as I'm constantly commuting to and from Manhattan here in NYC, and there's nothing better than listening to something on your headphones than to hear New Yorkers complain about their day. I remembered hearing a show about Bigfoot, a topic I never really took an interest in, and the co-host was so knowledgeable and passionate about the topic, and reminded me so much of myself when I talked about UFOs. That's when I contacted the host, Shannon LeGro, and we started talking about how cool it would be the start a show where we literally taught one another about a topic we knew very little about. And it sort of culminated into what is now Into the Fray, featuring Shannon, Sam Shearon, and myself. We chat weekly about weird news, the paranormal, cryptids, UFOs, and even true crimes, bringing on guests and experts to join the conversation. It's been an amazing ride, and we've really only begun!
I know a lot of people are calling you the bright young voice in the UFO field. You're in your 30s, which makes you about 30 years younger than the familiar names that we've all come to know. Who are some of your biggest influences?
My biggest influence and the person I consider my mentor in this field is author and investigative writer, Peter Robbins. Robbins, along with Larry Warren, wrote the British Best-Selling book, Left at East Gate: A First-hand Account of the Rendlesham Forest UFO Incident, Its Cover-up, and Investigation. After reading his book, I immediately contacted him to discuss this deeply compelling case and we've become wonderful friends and colleagues ever since. My other influences really come from those who aren't afraid to step out of the mold of nuts-and-bolts Ufology and dig a bit deeper to bring fresh perspectives to the phenomenon and the study of it. Those individuals include the late Mac Tonnies, who really inspired me to step out of the box and look at alternative theories on what UFOs may be and what the occupants who supposedly control them may represent other than aliens from outer space. Others who currently keep my own research fresh and exciting would have to be Greg Bishop, MJ Banias, and of course, Dr. Jaques Vallee. These researchers have (and continue) contributed so much to the field in terms of alternative ways of looking at and trying to explain aerial phenomena and the question of possible contact with non-human intelligence(s).
You've had your own UFO experience. On that, we share common ground. Care to describe it? How did you feel as it was happening? Did it change your worldview?
My interest stemmed from a sighting I had in 1995. I was twelve years old, and I was on a weekend getaway with my parents to the Saint Lawrence River, which runs all through upstate New York and separates The New York border from Canada. I was fishing off a dock one night, listening to Green Day on my headphones, and I notice three white lights reflecting in the water. I look up, and there's this massive triangular formation about 300 feet above me. There's this fuzzy orange/red sphere in the center of the formation. I couldn't see any type of structure, but I also couldn't see the stars behind this formation. I rip my headphones off and my disc-man goes flying down the dock, and I'm expecting to hear this thing above me, but there was nothing. All I could hear was the water hitting the dock. And I could feel this low vibration running behind my ears, down my neck, and into my chest. I yell for my Dad to come out and he sees this thing slowly disappear off in the distance. That night terrified me, and I became obsessed with UFOs after that. At the age of twelve, I started researching the UFO phenomenon and it opened the floodgates for me. I knew there was so much more out there than we're told or conditioned to believe. Whether or not what I saw that night was alien or man-made technology, I may never know. But it challenged my perception of reality and what is possible. And it's led me on a journey of both self-discovery and opened doors to opportunities I never would have imagined walking through. That sighting scared the living hell out of me, but I wouldn't trade it in a million years.
What's your take on the UFO phenomenon? Do you think we're being visited by alien beings in physical craft, our future selves from other dimensions or time slips, a kind of mass hallucination or something so out there, we don't even have a proper way of defining it?
I honestly believe all these theories as right. And wrong. And somewhere in between. We have spent the past seventy years studying UFOs in many different capacities and any type of singular answer remains just as elusive as it has since Kenneth Arnold's sighting over Mount Rainier when the term "flying saucer" made its way into the mainstream. But what some may not be aware of is that what Arnold saw that day actually weren't saucer shaped at all. A misquote in a newspaper ushered in this term, and for decades and decades after, people reported seeing flying saucers all over the world. This brings up the question of the mass hallucination you speak of. UFO researcher and author, David Clarke, termed this the "UFO Syndrome". We tend to connect many things to UFOs, even if they have conventional or prosaic answers. This is when we must remain objective and open to the possibility that UFOs may indeed have nothing to do with aliens whatsoever. Could they merely be manifestations of our own minds that we've been so culturally ingrained and conditioned to believe are little green men from space? It's possible. Could they in fact be humans from the future coming back to check on us? Possibly. The fact of the matter is, I have no fucking idea. But I'm going to keep taking the journey and see where the research leads me.
What do you think is the most fascinating but underreported UFO sighting of the past 60 years?
I would have to say that the 1976 Tehran UFO incident is the most fascinating sighting that I've personally come across. This case consisted of radar and visual sighting of an unidentified flying object over the capital of Iran. On September 19th, after several reports were phoned in to the local air traffic controllers, the Iranian Air Force was eventually called in to investigate. Two F-4 Phantom jets were sent up and observed a diamond-shaped craft, massive in size, floating effortlessly. The pilots reported losing instrumentation and communications as they approached, only to have them restored upon withdrawal; one of the aircraft also reported suffering temporary weapons systems failure, while preparing to open fire on the object. The case was later investigated by U.S. Intelligence as well, and information pertaining to the case is now available through the Freedom of Information Act. This is a documented case with ground radar, flight transmissions, and official documentation of unknown objects interacting with military aircraft. It also included pilot witness testimony and two government agencies from two different countries. Yet many people have never heard of it. It is certainly worth further exploration.
A lot of people are hooked on ancient alien theories. The show has definitely sparked some creative ways of looking at our past and linking events, places and people to UFOs and aliens. What do you think? Has the Earth been a way station for passing civilizations since time immemorial?
This is a massive can of anthropological worms that I simply haven't focused my efforts or time researching. While I find the work of Erich von Däniken or Zecharia Sitchin very interesting and alluring, there simply isn't enough proof, in my opinion, that this is the case. Now, I am not saying that IF aliens have visited our planet, that it began with a crash in 1947 in Roswell, but I believe we also do not give humankind enough credit of our vast intelligence and persistence to evolve and progress technologically. The idea that some sort of ancient extraterrestrial civilization has intervened in our history strips us of responsibility for that which we've created. It also opens an entire alternative history where these non-human intelligences have co-existed insidiously with us for countless centuries. Again, I have entertained the many theories brought forth by trailblazers in the ancient alien and ancient astronaut theory, but right now my attention is focused on moving my own sights towards the future of possible alien contact from a scientific standpoint, and even more ambitiously, from a consciousness standpoint. The only thing I know for certain, in terms of ancient aliens, is that if my hair ever grows to the towering heights of Giorgio Tsoukalos, someone please force me to get a haircut.
What's the one thing the UFO field has been missing or needs to improve upon not just to gain legitimacy in the mainstream, but move it forward to finally finding concrete answers?
In my opinion, there needs to be a convergence of the UFO experience and the UFO study. This topic covers the most broad umbrella one can possibly imagine. Whether seen through the lens of science, philosophy, theology, anthropology, psychologically, sociologically, economically, or even academically, there is a place in our world view for the phenomenon of the UFO. That being said, we need to find a way to bring forward the most analytical and credible data from each of these camps, get the top researchers in one room together, and hash it out. Instead of saying that one viewpoint isn't as important as the other, let's work together to really look at what this phenomenon could represent. Let's put a mirror up to ourselves and really ask the hard questions. There is some amazing scientific work being done on searching for extraterrestrial life right now by young, ambitious individuals. The same could be said in the fields of psychology and hypnotherapy in terms of possible alien abductions and/or contact with said aliens. While this may be extremely challenging, the outcome may be inevitably much more rewarding. We live in great times of uncertainty here in America and abroad. So maybe by coming together and putting that microscope on the human side of a possible alien phenomenon, we can glimpse into the heart of these mysteries and come out much more accepting of one another on the other side. As for concrete answers… I wouldn't bet on it!
Here are just a few quick hits :
Favorite part of a UFO con.
Meeting witnesses and experiencers who trust me enough to tell me their stories. There is nothing more galvanizing then sitting face to face and hearing the story straight from the individuals themselves. Those are the moments when it really hits me and I'm like, "Holy shit. This is really happening to these people. And there are things out there that we've only begun to understand."
Favorite UFO/Alien/Abduction movie.
I'm going to have to go with three different films on this one which all hold special places in my heart and mind. The first is "The Day the Earth Stood Still" (1951), "Close Encounter of the Third Kind" (1977) and "Arrival" (2016) — Hunter : "I almost have the same top 3, with War of the Worlds replacing The Day the Earth Stood Still.
Dream guest to have on your podcast.
Jaques Vallee. No question. The man is a legend in the UFO field in so many ways. Also, I wouldn't mind getting Chris Carter on just to be a fanboy for two hours straight. I am a self-professed "X-Phile." —Hunter : "I think I'd be too tongue tied to interview Chris. Fanboy paralysis"
Gray's Papaya hot dogs, yea or nay? (since you live in NY. And if you haven't had one yet, I'll treat!)
Had em. Loved em. But being from upstate NY, I have to represent Hoffman's Hotdogs. And don't even get me started on the coney snappy griller up in Syracuse, NY. If you've never had one, head up to the 'Cuse and ask for one. Just imagine a sweet and spicy hotdog… with relish of course!
Best book you've read about UFOs.
Passport to Magonia by Dr. Jaques Vallee. Leslie Kean's UFOs: Generals, Pilots, and Government Officials Go on the Record is a close second. — Hunter : "Just read the latter, will pick up the former. Great picks!"
The one place you'd love full and unfettered access to investigate.
Either Dugway Proving Ground in Utah (Supposedly an Area 52 location) or Hangar 18 in Wright Patterson AFB in Ohio.
Please tell us about your book, where folks can find it and learn more about you and your amazing work.
The book is called, Somewhere in the Skies: A Human Approach to an Alien Phenomenon. It covers a wide array of my two year investigation into UFOs, close encounters, and possible alien abductions. But rather than focus on the where and when, this book covers the who and the why, really putting a microscope on those who've had the experiences, what they believe it to be, and what they might tell us about what we may be dealing with somewhere in the skies.
All of my UFO work can be found at: www.somewhereintheskies.com
You can hear me on the Into the Fray Podcast at: www.intothefrayradio.com
For my stage and film work, you can visit: www.ryandsprague.com
Book is Available in Paperback and E-Book on Amazon at the following link: https://www.amazon.com/Somewhere-Skies-Human-Approach-Phenomenon/dp/0967799589/ref=sr_1_1?ie=UTF8&qid=1481577910&sr=8-1&keywords=somewhere+in+the+skies


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subset: commoncrawl


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Madhuri Dixit Pink Net Saree with Green Broket Blouse
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Overview: Madhuri Dixit Pink Net Saree with Green Broket Blouse
This stunning pink net saree was worn by Madhuri Dixit at the Jhalak Dikhlaja Grand Finale. Buy this gorgeous Madhuri Dixit replica pink net saree and look beautiful at any wedding or cocktail party. The saree is a unique ensemble brought to you by the house of Best Bollywood Replica. This ravishing Madhuri Dixit saree comes with neon pink and green sleeveless blouse. The blouse has gorgeous floral patterns on the body, which adds to the dazzle of the set. This graceful piece is completed with a stylish silver patterned border. The Madhuri Dixit saree is ideal for weddings, related occasions, parties, Bollywood functions, anniversaries, cocktail parties, dinner invitations or get togethers at the club. Wear this piece to look stunning and be the centre of any occasion. It is available to buy online.
The Madhuri Dixit saree is pink in colour and made of net material. The pink saree is accentuated with random mirror works on the bodice along-with matching mirror brocade. In order to keep up the beauty of this saree, it has been paired with a sleeveless blouse in pink and green flanked by floral patterns. The blouse material provided is black in colour with complimenting embroidery. The blouse fabric is velvet. Both the saree and blouse colour are suited for all Indian skin tones. The Madhuri Dixit saree comes with an elegant thin silver patterned border adding to the classy finish. The pallu is a similar design complimenting the beautiful piece. The silver thread is designed around the embroidery making this a high end replica. The Madhuri Dixit saree is light and comfortable allowing you to enjoy those parties while looking chic at the same time. The Madhuri Dixit saree is 5.5 metres in length. It is a freesize and will fit the average Indian woman. With an eye catching design and the dazzling embroidery, the Madhuri Dixit saree increases the style quotient wherever it is worn.
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Torchlight Mobile – First look at new mobile game from Perfect World
December 18th, 2016 | by cinderboy
If you did not already know, Perfect World is the primary investor in Runic Games, developer of the Torchlight series. Years
December 18th, 2016 | by cinderboy
If you did not already know, Perfect World is the primary investor in Runic Games, developer of the Torchlight series. Years
December 16th, 2016 | by cinderboy
The story about Dragon Nest's current situation in the industry is a very peculiar one. Korean developer Eyedentity Games was
December 15th, 2016 | by cinderboy
It seems common these days Korean developers are renting out their popular game IPs to Chinese studios for a fee
December 7th, 2016 | by cinderboy
ForwardWorks, the mobile gaming division set up by Sony from the ashes of PlayStation Mobile, today announced it will be
November 30th, 2016 | by cinderboy
While major mobile games studios are spending millions on getting popular IPs for their new games, SEGA's new "Soul Reverse" IP
November 30th, 2016 | by cinderboy
[Register now] Nexon Korea today invites fans to register for the public Limited Beta and experience the immense world of
November 29th, 2016 | by cinderboy
Developed by COCOONBEAT, Knight Slinger is Gamevil's latest addition to an ever-expanding library of high-quality mobile games. Knight Slinger's gameplay
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Since it was announced a few year back, much attention has been on Ragnarok Mobile, an upcoming mobile game developed
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Developed by Chinese studio Ledo Interactive, The Tale of Lost City is a new mobile RPG which recently launched in
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After a few weeks of delay to resolve bugs, Netmarble today announced Lineage II: Revolution will be launching in South
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Get Latest Jobs Via Email
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Show #70 - Healthtastic
It has been awhile since we last recorded a show, but we come bearing tidings of what we have been doing along with excuses. Heather and I have joined a gym and are trying to be healthy. We discuss our experiences of finding a place to work out, Heather's birthday, gay bars, and exciting yard work. We also listen to your voicemails and if you would like yours played on our show give us a call at 206-203-5613
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#!/usr/bin/python def overlap_pp(x,y): count = 0 for i in range(x): for j in range(y): count += i + j return count for _ in range(1000): q = overlap_pp(500,500)If you run the above script (saved as n.py) on the command line terminal with the time command you should see some numbers like the below
time ./n.py real 0m22.379s user 0m22.363s sys 0m0.407sThe process running on one processor took about 22 seconds to complete the run. Now lets do something seemingly magical. Lets add a decorator. Decorators are python speak for a mechanism to do wrapper functions. The decorator we are going to add is '@jit'. The code looks like as it is shown below
#!/usr/bin/python from numba import jit @jit def overlap_pp(x,y): count = 0 for i in range(x): for j in range(y): count += i + j return count for _ in range(1000): q = overlap_pp(500,500)Now let's time this as before.
time ./n.py real 0m0.420s user 0m0.370s sys 0m0.443s
Magic! The exact same code now runs 55x faster! This happens because the Just-In-Time (jit) feature of the numba package compiles the function to machine code on the fly. The timing you see is almost in line with what you would expect from a similar code done in C or Fortran. In fact you will be surprised that in this particular example, the numba version runs faster than the C version! The C code is shown below.
#include < stdio.h > int overlap_pp(int x,int y){ int i,j,q; for(i=0;i<= x;i++){ for(j=0;j<= y;j++){ q += i + j; } } return(q); } int main(int argc,char** argv){ int i,q; for(i = 0;i<=1000;i++){ q = overlap_pp(500,500); } return 0; }The timing results after compiling the above code 'gcc t.c -o t'
time ./t real 0m0.774s user 0m0.774s sys 0m0.000sUnfortunately there isn't a clear description online on how to get Numba installed on Ubuntu 14.04. After some hacking and poking around stackoverflow the following worked for me.
Step 1:
Numba uses llvm. You need to remove all llvm, llvm-config and llvmlite installations that you already have on your system. Numba needs llvm-3.8 upwards to work properly.
Step 2:
Follow instructions in this stackoverflow thread. But when you get installing do the following
sudo apt-get install zlib1g zlib1g-dev libedit2 libedit-dev llvm-3.8 llvm-3.8-dev
Notice change in version number to 3.8.
Step 3:
Next, install llvmlite. You also want to create a symbolic link on '/usr/bin/' to point to the latest 3.8 version of llvm-config.
"sudo ln -s /usr/bin/llvm-config-3.8 /usr/bin/llvm-config"
This step is important because the installation of numba appears to use llvm-config. After this you can install Numba directly using pip.
If you are interested in learning more about python programming, data science and probability here are a list of books that are worthwhile to buy.


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Articles tagged peter buck
20 Oct 2011 // 9:30 AM
John Wesley Harding teams up with Eugene Mirman for new video, "Sing Your Own Song", which spoofs a Paul Simon classic.READ more
22 Sep 2011 // 3:35 AM
Where R.E.M -- like any band -- really distances themselves and makes their true case for greatness is in the lesser-known and semi-obscure songs.READ more
5 Dec 2010 // 9:00 PM
R.E.M. made their Austin City Limits debut less than a month before the release of Accelerate. It's clear that they were excited about the album.READ more
15 Nov 2010 // 9:00 PM
Tired Pony couldn't have a picked a better name for itself. Just from their debut album, it sounds like they are ready to drop dead.READ more
12 Feb 2009 // 8:00 PM
For his second outing with the Venus 3, Robyn Hitchcock both tightens up his songs and adds to his arrangements with vocal harmonies and horns. The result is another winner.READ more
25 Jan 2009 // 8:00 PM
Charlie Pickett owned the night during the '80s, although you may not have heard of him yet.READ more
10 Jun 2008 // 2:20 AM
Now it can be told: In 2004, during the recording and release of the "Around the Sun" (Warner Bros.) album, R.E.M. was on theREAD more
1 Aug 2007 // 9:59 PM
These reissues of two late '90s Robyn Hitchcock albums find the surrealist singer-songwriter in prime form.READ more
Animal Collective "Kinda Bonkers" (Singles Going Steady) // Music
Hayley Kiyoko "Palace" (Justin Caruso Remix) (premiere) // Music
Marty Stuart "Way Out West" (Singles Going Steady) // Music
Katie Herzig "I Want to Make You Proud" (video) (premiere) // Music
'Who' Will Be the Next Doctor?
// Channel Surfing
"What shall it be? A Doctor with whip-smart delivery of his lines? A woman who will bewitch before she kicks a Dalek's ass? Oh, the possibilities...READ the article


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Год выхода: 2012
Описание: Nika has a short Italian boyfriend who is intrigued with her long legs, big tits and pretty face. She changes into lingerie and dances around while her cock blows up like an over inflated balloon. This tranny has the fattest cock in Rome, thicker than a bottle of olive oil with nuts smaller than garbanzo beans. A second man friend appears and can barely fit her fat dick tip in his mouth before the other takes a try too. Their efforts are fruitless and they opt to split her shitter instead. She sucks while one guy fucks and the 2 guys finish this sloppy Italian tranny off with a couple of large squirts to her overinflated boobs. She can barely fit her own hand around her massive third member which finally releases a respectable sized batch of her own.
Продолжительность: 00:24:51
Формат: WMV
Качество: HD
Видео: Windows Media Video 9 1280x720 29.97fps 2548kbps
Аудио: Windows Media Audio 44100Hz stereo 128kbps
Размер: 478 МБ
ThirdWorldxxx - Nika (2012) HD


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Hello everyone! By december ill be moving with my boyfriend to CT. We are wondering where is the best place to live. He will have a car and will be working during the day, so i wanted to get a place near the sea in order to go to the beach (nice beach, not the rocky ones) but also and very important be walking distance from commercial areas so as to be near people, movement, supermarket, etc and not feel so alone during the day.Which place would you recommend to live ir order to have both beach and commercial area? I have been told that camps bay has a nice beach but no social life walking distance.Thank you so very much, im eager to meet "Internations" in forward reunions!!Un beso!


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A Peek Into The WanderLust Girls
Posted on November 17 2015
Our editorial team stumbled upon the WanderLust Girls and fell effortlessly in fashion love with the duo.
Emily's commitment to balancing high fashion and comfort simply makes sense. She opts for wider heels (easier to walk in), loose blouses, texture, and simple lines. Abigail's realistic approach to style and fashion with traces of mystery are not only subtly sexy but filled with wanderlust inspiration. The fierce emerging fashion duo consistently sports big sweaters and trendy bleached blond tresses that are so crisp and fresh they give us goosebumps.
Lucky for us Emily and Abigail sat down to share what it takes to run a high fashion blog as well as provide snippets and tips into their personal style. Enjoy!
Your blog, WanderLust Girls, is not just about fashion but about beauty, travel, and more. Why did you start it? Any advice for newbies?
We both grew up in a small town just outside of Boston and met at the ripe age of 11. Throughout middle school and high school we shared our wardrobe. Either Abigail would buy the top and Emily would buy the bottoms, or we would just split the bill. (We're really good at sharing). We even happen to be the same shoe size. It was a match made in fashion Heaven.
So, when we went to separate colleges we both sort of panicked. Our wardrobe had been compromised! But we knew after we graduated that Abigail would move up to NYC and we would live together once again sharing our wardrobe.
To keep each other up to date on what we had bought while we were apart, we started a blog as fashion post cards to each other. We would put together a look and write back and forth to each other saying what the new item was that we would both soon own. After that, someone had to tell us that other people could read the posts (we were a bit confused on what a blog actually was) and that we should maybe shape it up and try and do something with it. So we did, and here we are!
The best advice is to comment on other blogs, reach out to companies and brands you want to work with on social networks. At times it can be hard to work for yourself, but that is true with any field.
When we first started trying to do this we did a lot of free work. The challenge was turning the corner of giving ourself some more worth after we had gained enough experience. But we did, and have continued to add worth to our blog and services. This business is always growing and we can't wait to see what comes next!
Your commitment to friendship and fashion is how WanderLust Girls came about? How cool and inspiring is that? Who are some of your favorite fashion bloggers that inspire you from time to time?
We both really love Sincerely Jules. She has such a sweet personality that you can really feel from her blog. We also love to follow jewelry designer Dylan Lex for her monochromatic magnificence.
Sincerely Jules does seem to be sweet and refreshing and who doesn't love a nice piece from Dylan Lex? If you had to choose - who are your top three high fashion designers or stylists?
Love them all. The newest collection by Saint Laurent is everything.
So aside from your extraordinary and wanderlust inspired style what do you ladies do outside of your blog?
It's really hard to tell what is "outside" of the blog these days because we live together as well and we share a lot of the same friends.
To sum ourselves up outside of the blog... we're kind of like rock and roll grandmas. We love staying in, drinking tea and watching friends, or we're the complete opposite dressed in lots of leather and kicking it at a local dive bar or dancing at a hole in the wall concert venue.
There is no real in between. We're very close with our families as well. There is a lot of Facetiming that goes on in our apartment.
You're living the dream and thank goodness for FaceTime. We love all the looks on your blog. What inspires them?
Our personal style definitely has a downtown vibe and a whole lot of rock and roll influences. Abigail's style is typically tomboy chic, inspired by a casual 'model off duty' look. Emily is more feminine, and a bit more emo. She draws from poets like Poe and Tim Burton.
We must ask - what are you "go-to" outfits and one of your most memorable ones?
Emily's go to look is Aritzia vegan leather leggings, a black tee, and simple black vince boots. Emily's most memorable outfit was actually a costume that our good friend Ami Goodheart created. Her aforementioned love for Edgar Allan Poe came to it's peak when Ami loaned this black raven gown she had created.
Abigail's go to look is black pants, a white tee, and a leather jacket. Abigail's most memorable outfit was an all snakeskin print look that was snapped by several magazines during Fashion Week.
Love it all ladies! What are the best ways for our readers to stay in touch with you?
Our readers usually reach out via Instagram in the comments. We're definitely on that media the most. We always say be active in the blogging community.
Don't forget to pay Abigail and Emily a visit at the Wanderlust Girls, they are a great read and come highly recommended by us. Follow them on Instagram too.
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Public User Randonley Appeared
Hey all i have a query to if i have been hacked or if it's an odoo feature.
Yesterday there was my user only (Fresh Install)
Now there is a quote draft that is blank to a customer called Public User and the Login of Public User.
If i go to delete it says cant delete bkah blah res.users look into my users and the user isn't in that list at all ive turned off filters and still no clue.
Is this todo with one of the modules or have i been hacked?
Can't imagine user spontaniouslt popping up out of nowhere, so I think we can easily exclude that option. Have you installed OpenERP and/or any module with the demo data on?
Also, have you installed the portal module? That offers the functionality for customers to login to your system. If you configured a customer it might hav sent out an invitation to that specific customer email adress and they might have responded on it.
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|Asked: 10/13/14, 12:29 PM
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An ordinary village in Northern China, the last day of the winter vacation. Four idle, aimless adolescents gather at Zhou Zhixin's home, a friend who lives with his father, brother and nephew. Like most contemporary teenagers, these youths want to enjoy their last day of holiday and simply hang out in this place where nothing ever seems likely to happen. Their conversations are desultory and they sometimes seem to argue for argument's sake. One of them, Laowu, talks frankly with his girlfriend about how teenage love might affect their studies, while Laobao questions school's value and relevance to real life.
A young boy and his sister spend a summer at their grandparents' house in the country while their mother recuperates from an illness. They while away the hours climbing trees, swimming in a stream, searching for missing cattle, and coming to uneasy grips with the enigmatic and sometimes threatening realities of adult life.
John Blackwell Project came together after the 2008 Buddy Rich Memorial Concert to create a stellar album with a truly unique and varied collection of innovative fusion tunes, the basic tracks for 4ever Jia were recorded at DrumChannel in Oxnard, California. The album's influences are drawn from funk,fusion and jazz, something for everyone and some tunes that will have you singing in no time.


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We investigated the influence of type one cannabinoid receptor (CB1) deficiency on acute heart failure (AHF) and the underlying mechanism. Acute heart failure syndrome is an important clinical problem because of its high morbidity and mortality rates. Activation of CB1 induces vascular dilation and reinforces the properties of morphine, long-standing therapies for AHF syndrome, but the effect of endogenous CB1 activation on AHF is largely unknown.
Acute heart failure mouse model characterized by hypertension and pulmonary oedema was created by using transverse aortic constriction (TAC). Mortality, echocardiography, haemodynamic, morphology, and circulatory catecholamine levels in response to TAC were evaluated in CB1 knockout (KO) and wild-type mice. Type one cannabinoid receptor KO mice had a much higher mortality rate at 1 week after TAC attributable to AHF (65 vs. 11%, P< 0.001). One hour after TAC, CB1 KO mice had significant larger lung weight to body weight ratio (LW/BW, 14.53 + 1.09 mg/g in KO vs. 10.42 + 0.36 mg/g in WT, P < 0.01) and higher plasma epinephrine levels (9720 + 1226 pg/mL vs. 6378 + 832 pg/mL, P < 0.05). Pharmacological activation of CB1 reduced LW/BW in wild-type mice. Administration of epinephrine to wild-type TAC mice significantly increased left ventricular end-diastolic pressure and LW/BW, while CB1 agonists reduced the LW/BW and the plasma levels of catecholamine and increased myocardial activity of AMP-activated protein kinase.
Endogenous activation of CB1 in mice has cardiac protection in AHF, which is attributable to the inhibition of excessive sympathetic activation.
Patients with cardiovascular diseases are increasingly hospitalized due to acute heart failure syndromes (AHFS). However, traditional therapies for AHFS, such as oxygen, loop diuretics, nitrates, and morphine have significant limitations, and the mortality rate remains relatively high,1 indicating the need to develop more effective treatments. Cannabinoids have not only neurobehavioural, but also cardiovascular effects.2,3 Both of cannabinoids receptors 1 and 2 (CB1 and CB2, respectively) exist in the cardiovascular system.4,5 Recent published literature has addressed the influence of CB1 activation on the uncommon forms of heart failure induced by hepatic cirrhosis or doxorubicin,6 however, the influence of endogenous CB1 activation on the classical AHFS remains poorly understood.
Type one cannabinoid receptor agonists have been shown to exhibit a vasodilatory effect,7 inhibit the release of neurohormonal factors,8 improve myocardial energy metabolism,9 and suppress vasopressin-induced vasoconstriction.10 More importantly, it was reported that a CB1 antagonist increased the acute mortality rate after myocardial infarction in rats.11 These findings raise the possibility that CB1 signalling may play an important role in AHFS.
In the present study, we hypothesized that activation of CB1 might be beneficial for AHF. To verify this hypothesis, we first established a murine model of AHF mimicking the clinic profiles of pulmonary oedema and high blood pressure, and then investigated the influence of the CB1 activity in AHF by studying the cardiac changes in CB1 knockout (KO) mice and the influence of CB1 agonists or antagonists on heart function in wild-type (WT) mice as well as the underlying mechanism.
WIN 55,212-2 (WIN), and AM 251, [N-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide], were purchased from Tocris Bioscience (Ellisville, MO). 2-Arachidonyl glycerol (2-AG) was purchased from Sigma RBI. Epinephrine was purchased from Sigma Chemical Company (see Supplementary material online).
Transverse aortic constriction model
All procedures were performed in accordance with our institutional guidelines for animal research that conformed to the 'Position of the American Heart Association on Research Animal Use' adopted by the AHA on 11 November 1984. Type one cannabinoid receptor(−/−), CB1(+/+) or C57 mice were used. Development of mice lacking CB1 was previously described by Ledent et al.2 Male C57BL/6 mice (7 weeks old and weighing 20–24 g) or ICR or CB1 mice (5–7 weeks) were anaesthetized with pentobarbital sodium (50 mg/kg). To induce acute pulmonary oedema, transverse aortic constriction (TAC) was performed as described elsewhere,12 degree of aortic stenosis was controlled by the size of the banded needle which was withdraw after aortic ligation and confirmed by the pressure gradient across the banded site (Figure 1A), which was usually >50 mmHg at the 3rd day after TAC in our laboratory.
Transthoracic echocardiography was performed with a Sonos 4500 and a 15-6 L MHz transducer (Philips, the Netherlands) and invasive assessment of haemodynamic was carried out using a Millar catheter (see Supplementary material online).
Measurement of catecholamine and endocannabinoids and blood cell counts
Plasma catecholamine (epinephrine, norepinephrine, and dopamine) were measured by SRL, Inc. (Kyoto, Japan) using high-performance liquid chromatography (HPLC). Anandamide (AEA) and N-oleoylethanolamine (OEA) in the heart and lung samples HPLC–tandem mass spectrometry (HPLC/MS-MS) (see Supplementary material online).
Circulating blood cell counts (red cells, leucocytes, and platelets) were measured using a Sysmex KX-21 hematology analyzer (Sysmex, Japan) (see Supplementary material online, Methods).
Cell culture and immunoblotting
Ventricular myocytes were isolated from neonatal rats at 2–3 days of life and cultured. Proteins were prepared from cultured cardiomyocytes or whole hearts of mice. Then immunoblotting was performed using mouse antibodies directed against phosphorylated AMP-activated protein kinase (AMPK), which recognizes the AMPK pan-subunit phosphorylated at Thr-172, or AMPK (Cell Signaling). Immunoreactive bands were visualized by the enhanced chemiluminescence method (Amersham) and then were quantified by densitometry with Scion Image software.
Knockdown of rat type one cannabinoid receptor using siRNA and real-time PCR
Neonatal rat cardiomyocytes at 50–70% confluence were transfected with CB1 siRNA (designed and synthesized by B-Bridge International, Inc.) with Optifect (Invitrogen Co.). SiRNA for CB1 was transfected at 66 nM at 4–6 h after plating of cells into a 60-mm culture dish. The siRNA sequences were 5′-ggg aag aug aac aag cuu a-TT (sense) and 5′-uaa gcu ugu uca ucu ucc c-TT (antisense), while the control siRNA was uag cga cua aac aca uca a-dTdT.
Real-time PCR for fatty acid amide hydrolase (FAAH) and the monoacylglycerol lipase (MAGL) in heart and lung was performed using a Quantitect SYBR Green RT-PCR kit (DRR420A,Takara, Japan) (See Supplementary material online, Methods).
Statistical analysis
The SPSS 16.0 (Chicago, USA) software was used for analysis. The unpaired and paired t-tests were used for comparisons between two groups and between different conditions within the same group, respectively. One-way ANOVA with post hoc analysis by the Tukey–Kramer exact probability test was employed for multiple comparisons. Survival analysis was performed using Kaplan Meier curves with Log-rank test for comparison between the groups. Results were expressed as the mean ± SEM and P< 0.05 was considered to indicate statistical significance. All the tests were two-sided.
Confirmation of acute heart failure model
One hour after TAC, left ventricular systolic pressure (LVSP) was increased to ∼170 mmHg in both ICR and C57 mice (Figure 1B). Left ventricular end-diastolic pressure (LVEDP) was increased by more than 2 folds, dp/dt min was dramatically reduced, and the exponential time constant of relaxation (tau) was markedly extended (Figure 1B–E), indicating a diastolic AHF was successfully induced by TAC. Lung weight/body weight ratio (LW/BW) was significantly increased by ∼90% in both ICR and C57 TAC mice (Figure 1F), indicating an acute pulmonary oedema occurred.
Higher mortality of type one cannabinoid receptor deficiency mice in response to transverse aortic constriction
The survival curve showed that nearly 65% of CB1 KO mice vs. 11% of WT mice died during the first week after TAC (Figure 2A). By daily observation of the mice and performing autopsy of the dead animals, we found that acute pulmonary oedema was the major cause of death, as indicated by the presence of pulmonary haemorrhage/oedema (Figure 2B). The LW/BW ratio was usually higher than 12 mg/g (more than two folds of the normal value) in mice that died of AHF. These results indicate that CB1 activation is crucial to protect the heart from acute pulmonary oedema.
Acute cardiac effects of type one cannabinoid receptor inactivation or activation
When the mice were subjected to TAC and sacrificed after 1 h, we found that the CB1 KO mice developed more severe pulmonary oedema. There was a significant difference of LW/BW ratio between the KO and WT mice (nearly 40% larger in KO group than in WT group, Figure 3A and B), suggesting that CB1 plays an important role in pulmonary oedema.
We then examined echocardiograph and LV haemodynamic parameters of cardiac function. At 10 min after TAC, CB1 KO mice showed a significant decrease of LV fractional shortening (LV dimensions and wall thickness are showed in Supplementary material online, Figure S1), whereas no significant change was observed in WT mice (Figure 3C). At 30 min after TAC, the extent of pressure overload (i.e. the LVSP) was similar between CB1 KO mice and WT mice (Figure 3D), but, CB1 KO mice had a lower LV dp/dt max (reduced by 30%) and dp/dt min (reduced by 50%), a lower contractility index, and a larger tau (Figure 3E). These data indicated that CB1 inactivation was detrimental to both systolic and diastolic cardiac function in the context of pressure overload.
Type one cannabinoid receptor deficiency promotes catecholamine release in response to transverse aortic constriction
At one hour after TAC, catecholamine was elevated significantly in both KO and WT mice (Figure 3F–H), but CB1 KO mice had much higher epinephrine (152% of WT) and norepinephrine (231% of WT) levels than WT mice (Figure 3G and H). The decrease in CB1 activity dependent dopamine release may be one of the reasons for the lower plasma concentration of dopamine following TAC in CB1 KO mice than in WT mice, which was in agreement with previous studies.13 It was plausible that the extremely high epinephrine and norepinephrine levels in CB1 KO mice might have contributed to their high mortality.
Influence of epinephrine on left ventricular haemodynamic and pulmonary oedema
In both normal and TAC wild-type mice, LVEDP was significantly elevated after intraperitoneal injection of epinephrine at 2 mg/kg (Figure 4B). Epinephrine increased the LVSP, heart rate, and LV contractility index more markedly in normal mice than in TAC mice (Figure 4A and C–E), suggesting that excessive sympathetic activation led to suppression of cardiac diastolic function. We further confirmed that epinephrine exaggerated acute pulmonary oedema in TAC mice indicated by a 25% increase of LW/BW (Figure 4F).
Effects of type one cannabinoid receptor inactivation on haemodynamic, blood cell counts and endocannabinoids system
Genotyping results are showed in Figure 5A. Intraperitoneal injection of CB1 agonist WIN exerted no effect on systolic blood pressure in CB1 KO mice while it decreased blood pressure markedly in WT mice (Figure 5B), and greater suppression of heart rate was also noted in WT mice (Figure 5C), indicating a vascular dilatory effect and a negative chronotropic character of CB1 activation.
No significant differences on peripheral blood cell counts were found between WT and KO mice in either sham or TAC groups (Figure 5D). Cardiac FAAH expression level was higher in WT sham group than in KO sham group (P < 0.05), which was down-regulated in WT TAC group (P < 0.05), whereas there was no significant difference between KO sham and KO TAC groups (Figure 5E). Pulmonary FAAH expression level was a little lower but with statistical significance in WT TAC mice than in WT sham mice (P < 0.05) (Figure 5F). Monoacylglycerol lipase gene expression in hearts of WT TAC mice was significantly lower than in KO TAC mice (P < 0.01) (Figure 5E), while no significant differences were found on pulmonary MAGL expression among the four groups (Figure 5F) (also see Supplementary material online, Figure S2).
We further measured endogenous cannabinoids in heart and lung samples and found that there were no significant differences on AEA and OEA contents between WT and KO sham mice. Different from WT mice, both AEA and OEA contents in lung tissues were significantly decreased in KO mice after TAC (P < 0.05) (Figure 5G and H).
Type one cannabinoid receptor agonists rescue acute heart failure
We next tested the effects of two CB1 agonists WIN and 2-AG and a selective CB1 antagonist (AM251) on acute pulmonary oedema. These drugs were administrated before the performance of TAC. One hour after TAC, we sacrificed the mice and evaluated the LW/BW ratio. Treatment with either WIN (0.2 mg/kg) or 2-AG (5 mg/kg) significantly reduced LW/BW by ∼30 and 40%, respectively (P < 0.05 and 0.01), while the administration of AM251 (0.3 mg/kg) increased it by 10% (Figure 6A). We also evaluated the effect of CB1 activation on catecholamine and LV function. In WT TAC mice, WIN did not suppress cardiac systolic function (Figure 6B), but caused a significant decrease in LVEDP by ∼60% (P < 0.01), an index of pulmonary congestion, and also slowed the heart rate (Figure 6C and D).
In addition to the preventive use of CB1 agonists, we further evaluated their therapeutic effect on pulmonary congestion. One hour after the TAC, WIN, 2-AG, or AM251 was given to the mice at the same dosage as above described and LW/BW was measured 24 h later. We noted that WIN and 2-AG reduced LW/BW by ∼28 and 30%, respectively (P < 0.05), while the administration of AM251 increased it by 13% (P > 0.05. Supplementary material online, Figure S4).
Effects of type one cannabinoid receptor activation on plasma catecholamine and AMP-activated protein kinase activity
WIN reduced circulatory epinephrine by 27% and norepinephrine by 37% in wild-type TAC mice (P < 0.01, Figure 7A). In cultured cardiomyocytes, co-culture with WIN for 30–60 min significantly enhanced AMPK activity (Figure 7B), and this effect was abrogated by knockdown of CB1 (Figure 7C). Similarly, phosphorylation of AMPK was also increased in WIN-treated WT sham and TAC mice (Figure 7D and E).
In this study, we found that CB1 plays a previously unrecognized role in acute pulmonary oedema resulting from LV pressure overload. Type one cannabinoid receptor KO mice with pressure overload displayed high levels of catecholamine, severe acute pulmonary oedema, and a high acute mortality rate, while administration of epinephrine to WT mice increased LVEDP and exaggerated pulmonary oedema, indicating that excessive sympathetic activation contributed to the worsening of AHF. Since inhibition of catecholamine release is a well-recognized effect of CB1 agonists8,14 and pressure overload-induced stress stimulates sympathetic activity, it seems reasonable that high catecholamine levels were found in CB1 KO mice after TAC. Notably, the decrease in pulmonary endogenous cannabinoids following pressure overload might have also contributed to the severer pulmonary oedema in KO mice, suggesting a cardioprotection conferred by endocannabinoids.
Most patients with AHFS present with pulmonary oedema and a normal-to-high systolic blood pressure,15 which is similar to our murine model of AHF. Currently available vasodilators used to treat AHFS include nitroglycerin, nitroprusside, and nesiritide, which were reported to ameliorate symptoms and improve clinical status, but did not decrease the mortality rate.16–18 Our results in the present study that mortality of AHF was increased in CB1 deficient mice and pulmonary oedema was improved by CB1 agonists in WT mice would raise new hope for the treatment of acute heart failure.
Beneficial effects of cannabinoids have been observed in various critical cardiovascular diseases such as septic shock, myocardial ischaemia/reperfusion injury, or myocardial infarction.11,19–23 A wealth of data have shown that cardiovascular beneficial effects could be mediated by activation of either CB2 or CB1,24–27 however, deleterious actions of CB1 activation on doxorubicin-induced cardiac dysfunction have also been reported.26,28 Emerging evidence shows that selective CB1-receptor blockade with rimonabant significantly promotes reduction in weight and favourable changes in cardiometabolic risk factors,29,30 which are at least in part attributable to blocking the role of cannabinoids on appetite stimulation.31 Several recent published reports from almost the same laboratories have suggested that CB1 antagonist rimonabant is protective in some non-classical forms of heart failure induced by hepatic cirrhosis and doxorubicin.28,32,33 It should keep in mind that those forms of heart failure are largely different from the classical types. On the other hand, similar to beta 1 blocker, CB1 agonists have negative inotropic effect, thus it is not surprising that CB1 activation reduced myocardial contractility in hepatic cirrhosis or doxrubicine-induced heart failure.28,32,33 Lim et al.34 reported that rimonabant reduced infarct size in wild-type mice, but in untreated mice, infarct size was similar between CB1 KO and wild-type groups, suggesting that rimonabant has CB1-independent cardioprotective role. Paradoxically, a recent published large clinical trial (RESCENDO) showed that rimonabant did not improve major vascular event-free survival in obesity patients with previously manifest or increased risk of vascular disease at a mean follow-up of 14 months,35 which is by coincidence in agreement with previous experimental studies.11,23 It seems plausible that agents for reducing cardiovascular risk factors are not necessarily effective for treatment of overt cardiovascular disease. Noticeably, a recent review of endocannabinoid effects on the heart by Hiley26 shows that it is not possible yet to define CB1 activation simply as protective or injurious to the cardiovascular system, though the balance does seem to favour a protective role. Therefore, extensively studies to address this issue should be encouraged.
Pulmonary congestion is one of the main reasons for admission and readmission in patients with AHFS. The pathophysiology may be dominated by hypertension and neurohormonal activation resulting in increased LV filling pressure. Our murine model of AHF was characterized by hypertension and neurohormonal activation as well as pulmonary oedema. This study implicated that endogenous activation of CB1 seems to meet at least three ideal properties for an AHFS therapy36: (i) improve pulmonary congestion, (ii) improve haemodynamic, and (iii) improve the neurohormonal profile. Other pharmacological properties of CB1 activation may also favour AHFS, for example, limiting damage to the heart,20,23 stimulating AMP-activated protein kinase activity in cardiomyocytes as showed in this study and elsewhere,9 reinforcing properties of morphine,2 a long-standing therapy for AHFS recommended by Practice Guidelines.37 For patients with AHFS, in addition to optimal therapy, metabolic modulators are an attractive choice of co-treatment. AMP-activated protein kinase activation is an important preventative therapeutic target for the progression of heart failure.38,39 We postulate that CB1 agonists may exert additional benefit for the failing heart by improving energy metabolism through enhancement of AMPK activity.
Accumulated evidence shows that endocannabinoids seem to be produced 'on demand'.40 Our findings in this study suggest that endocannabinoids fulfill a protective role in AHF. Therefore, pharmacologically manipulation of endocannabinoid levels might be a possible therapeutic approach for AHFS.
Supplementary material
Supplementary material is available at European Heart Journal online.
This work was supported by grants from the Department of Education of Guangdong Provincial Government and the Southern Medical University, China (to Y.L.), the Japanese Ministry of Education, Culture, Sports, Science and Technology, Japan Heart Foundation, and Japan Cardiovascular Research Foundation (to M.K.).
Conflict of interest: none declared.
We thank Dr Weili Han, Dr Ande Ma (School of Public Health and Tropical Medicine), and Dr Chunyan Wang (Nanfang Hospital) for their valuable technical assistance.


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View lesbian Singles in Greenfield
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Search for your match in the Hoosier State and find online personals in Indiana. Relationships are a two-way street, start searching for your match today! Think about how much you spend on a night out at a bar. Or how much you spend on a movie and a bag of popcorn. How quickly would you give up one of these for a lifetime of love with someone special? Is it worth it? Get started now and find out for yourself! Love works miracles every day - so does Match.com in Greenfield. Every year, hundreds of thousands of people find love on Match.com.
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Tag Archives: pattern-making
The Britex Blog
Self-drafted Outfit in Khaki & Silk
June 9, 2014 by Nicole at Homebutton-down shirt and an unblogged bias-cut skirt), but this assignment was to draft a garment of our own design, then sew it in fashion fabric. We were allowed to make our final project in our own measurements, and being the pragmatic that I am, I designed a fairly basic work-appropriate outfit. Perhaps I should have made something a little more exciting, but this way, I'll get a lot of use out of my hard work! Both fabrics are from Britex, and I selected them for just such an outfit.
Craftsy Classes by Apparel Arts' Suzy
February 4, 2014 by Britex Fabrics
If you are seriously looking to sharpen your sewing skills and you live in the San Francisco area, you go to Apparel Arts, which you probably already know about since the design school hosted several Pop-up Britex workshops last year. What's new is that Suzy, director of Apparel Arts, is now offering patternmaking classes on Craftsy, an online community of makers. Yes, it's true. You can now learn the basics of patternmaking at your own pace, in your own home. Of course, this does not take the place of participating in an Apparel Arts class in person, but it is a good fix for greatly advancing your patternmaking skills!
Patternmaking Basics: The Skirt Sloper
Patternmaking Basics: The Bodice Sloper
Patternmaking + Design: Creative Darts & Seam Lines
Take a look and let us know what you think!
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Jessica Joy Rees, 12, dies of brain cancer after 10-month fight
JohnThomas Didymus
Jan 7, 2012 in
Jessica Joy Rees died on Thursday after a 10-month struggle with brain cancer. Her parents said on her Facebook page: "We have prayed and prayed and prayed for sweet Jessie to be healed here on earth but God's plan was to use heaven for healing."
Jessica, 12, was diagnosed with an inoperable brain tumor in March. A second tumor was found six months later in September.
Associated Press
reports that before she died, Jessica had hoped to reach the goal of collecting 50,000 "Joy Jars" filled with candy and toys for sick children.
By Friday after she died, her goal to collect "likes" on her
page, one each for 50,000 American children with cancer, had surpassed its goal. Her parents posted a message on her Facebook page that said: "Thank you all for honoring Jessie by helping her reach her 50,000 goal today. We will NEVER EVER GIVE UP spreading hope, joy and love to kids fighting cancer. Jessie's dream is now our destination!"
The Parents of Jessica, Eric and Stacey Rees, called on friends to pray for their family and promised to continue support for cancer research.
Jessica, a seventh-grader, began a blog and
page after she was diagnosed of brain cancer in March. Before she died, Jessica bravely blogged about her struggle with cancer, under the acronym NEGU ("Never Ever Give Up"). She wrote about her struggles with cancer, radiation and chemotherapy treatments she received. She campaigned for her followers to support pediatric cancer research and pray for other children with cancer.
Jessica started the
NEGU Foundation
, a nonprofit organization with her parents. The organization was dedicated to raising awareness about pediatric cancer and raise money for research. NEGU sold
filled with candy and toys for sick children. More than 3,000 "JoyJars" were sold and distributed in 27 states last year.
Jessica on her Facebook page said her mission was to "to encourage kids fighting cancer to Never Ever Give Up by spreading hope, joy and love. A cheerful heart is great medicine." She wrote on her Facebook page: "I love spreading joy to kids with our JoyJars. I love reading all of the posts on Facebook. I love having so many people praying for me. I love that people are supporting NEGU and allowing us to help kids. I love my family and all of my new friends."
Jessica's father Erik Rees, is a pastor at the Saddleback Church in Lake Forest
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Symphony No. 1 In D Major ("Titan"): II. Kräftig Bewegt
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Ready, set — let's get healthy
It's no secret that we love safety. But what you might not realize is that we love health and wellness too — which is why we've partnered with employee well-being experts, Virgin Pulse, to offer an online worksite wellness program.
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Description of Braehead Glamping
Set in the picturesque Speyside area in the North East of Scotland, our six pods offer unique glamping accommodation.
Each pod offers something a little different, to suit your needs.
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Our Glen Grant and Glen Moray pods sleep four in single beds and double futons/sofa beds. These pods require you to bring your own bedding, or alternatively this can be hired from us.
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Heated and insulated wooden pods
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At a minimum they sleep two people, with some accommodating four.
In addition, we have the option with certain pods to add camp beds, futons or sofa beds for extra guests.
Communal Areas
- Dining
- Kitchen
- Reception
- Shared Showers
- Shared Toilets
- Washing Up
Our Bothy Barn is a great space to relax during your stay at Braehead, with full cooking facilities and a log burner.
There are picnic tables situated on site to be enjoyed during the summer.
Shared Amenities
- Children's Play Area
- Shop
Our shop, The Trading Post, sells basic foods and camping goods, including disposable BBQs and firewood for your stay at Braehead, as well as treats for adults and children.
What to bring?
- Basic Provisions
- Sleeping Bags
- Towels
Full bedding is provided in our Glenfiddich and Glenfarclas pods.
You are required to bring your own bedding for all other pods, or this can be hired via Braehead at a cost of £3 per person.
All crockery and cutlery can be found in the Bothy Barn.