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In this renewal application we describe the progress of our research over the last four years on studies of the molecular mechanisms and controls that regulate the functions of DNA replication and RNA transcription complexes. Our studies have used primarily biophysical methods, and have primarily involved the replication complex of bacteriophage T4 and the transcription complex of E. coli. However, these systems feature essentially the same molecular mechanisms for 'driving'and regulating these central life processes as those that characterize 'higher organisms', including humans. As a result these studies provide good model systems to examine how human replication and transcription proceed at the fundamental level, and provide insights into what goes wrong at these levels in various forms of cancer and genetic diseases that often seem to involve minor kinetic or structural changes in the properties of these 'macromolecular machines'. During the last reporting period we completed a number of studies on the above mechanistic questions, using reconstituted replication or transcription complexes that carry out their functions with essentially the same rates, fidelities and processivities as the in vivo versions of the same complexes within real cells. In these studies we placed fluorescent base analogue probes at defined positions within the nucleic acid frameworks of the reconstituted complexes, and then used fluorescent and circular dichroism spectroscopy at wavelengths great than 300 nm (an optical range in which the rest of the protein and nucleic acid components of the complexes are transparent) to monitor biologically relevant conformational changes at the probe sites. By these means we obtained significant information about replication and transcription mechanisms under steady state or equilibrium conditions. During the next reporting period we will follow up on preliminary studies that have shown that various versions of these same optical probe approaches can be used in more complex optical set-ups to permit two-dimensional fluorescence spectroscopic (2DFS) and single molecule Fluorescence Resonance Energy Transfer (smFRET) and Fluorescence Linear Dichroism (smFLD) measurements that can follow the kinetics of reactions within these complexes in 'real time'and with msec to msec resolution. This now gives us the opportunity to obtain local structural and dynamic information on changes at defined and biologically-relevant base analogue and DNA backbone probe sites, as well as to map transition states within individual rate-limiting molecular steps in transcription and replication. We believe that by using these approaches we can reveal new aspects of mechanisms and regulatory control systems that were previously inaccessible to direct experimental measurement, and should provide new and valuable fundamental information to understand cell processes and differentiation and to learn what goes wrong at the molecular level in related disease states.
Protein-nucleic acid complexes work in living cells to: (i) faithfully replicate (copy) the DNA genome to form the genetic material of the daughter cells;(ii) to transcribe and process specific messenger RNA sequences to permit 'expression'of the defined genes;and (iii) direct the synthesis of specific required proteins at various stages of development. These molecular complexes, which drive and direct these central processes of cellular function, largely self-assemble from individual protein and nucleic acid components to form the so-called 'macromolecular machines of gene expression'. We are continuing a program of research that uses the methods of physics and chemistry to understand the specific molecular processes that are involved in the functioning and regulation of these machines. Most of our work uses bacterial and viral systems as model organisms for simplicity, but the results also apply fully to our understanding of the processes of gene expression in higher organisms and humans. Understanding these central processes in molecular detail will help to develop specific tools to control diseases of anomalous gene expression and development, including various forms of cancer and related genetic diseases.
|Lee, Wonbae; von Hippel, Peter H; Marcus, Andrew H (2014) Internally labeled Cy3/Cy5 DNA constructs show greatly enhanced photo-stability in single-molecule FRET experiments. Nucleic Acids Res 42:5967-77
|Widom, Julia R; Johnson, Neil P; von Hippel, Peter H et al. (2013) Solution conformation of 2-aminopurine (2-AP) dinucleotide determined by ultraviolet 2D fluorescence spectroscopy (UV-2D FS). New J Phys 15:
|Phelps, Carey; Lee, Wonbae; Jose, Davis et al. (2013) Single-molecule FRET and linear dichroism studies of DNA breathing and helicase binding at replication fork junctions. Proc Natl Acad Sci U S A 110:17320-5
|Lee, Wonbae; Jose, Davis; Phelps, Carey et al. (2013) A single-molecule view of the assembly pathway, subunit stoichiometry, and unwinding activity of the bacteriophage T4 primosome (helicase-primase) complex. Biochemistry 52:3157-70
|Widom, Julia R; Rappoport, Dmitrij; Perdomo-Ortiz, Alejandro et al. (2013) Electronic transition moments of 6-methyl isoxanthopterin--a fluorescent analogue of the nucleic acid base guanine. Nucleic Acids Res 41:995-1004
|Datta, Kausiki; Johnson, Neil P; Villani, Giuseppe et al. (2012) Characterization of the 6-methyl isoxanthopterin (6-MI) base analog dimer, a spectroscopic probe for monitoring guanine base conformations at specific sites in nucleic acids. Nucleic Acids Res 40:1191-202
|Greive, Sandra J; Goodarzi, Jim P; Weitzel, Steven E et al. (2011) Development of a "modular" scheme to describe the kinetics of transcript elongation by RNA polymerase. Biophys J 101:1155-65
|Greive, Sandra J; Dyer, Brandon A; Weitzel, Steven E et al. (2011) Fitting experimental transcription data with a comprehensive template-dependent modular kinetic model. Biophys J 101:1166-74
|Datta, Kausiki; Johnson, Neil P; von Hippel, Peter H (2010) DNA conformational changes at the primer-template junction regulate the fidelity of replication by DNA polymerase. Proc Natl Acad Sci U S A 107:17980-5
|Datta, Kausiki; Johnson, Neil P; LiCata, Vince J et al. (2009) Local conformations and competitive binding affinities of single- and double-stranded primer-template DNA at the polymerization and editing active sites of DNA polymerases. J Biol Chem 284:17180-93
Showing the most recent 10 out of 78 publications


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The challenge, how does one present 50's synchronized swimming, or water works like the Bellagio fountain in Las Vegas, without water. Pushing string with a motor is not a new idea. Adding servo motors and a microcontroller to create automated and interactive installation is what I was looking to do during my residency at Autodesk's new facility on Pier 9.
This Instructable goes through the assembly of one of my 1/4 scale string fountains. The second image above is 6 string fountains arraigned in a circle moving string though the air.

subset: commoncrawl


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The Profit's Marcus Lemonis travels to Cuba at a time of historic change, and profiles a new breed of business owners determined to succeed under one of the most oppressive regimes in the world.
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Ground Zero Rising: Freedom vs. Fear
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As the fifteenth anniversary of 9/11 approaches, CNBC's Jim Cramer takes an in-depth look at the redevelopment of the 16-acre site.
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Our virtual tour can help you and your child feel as comfortable as possible so you know what to expect when you arrive.
With more than 300 pediatricians and specialists, we provide world class care for children and
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Appendicitis occurs when the appendix, an appendage (extension) of the colon, becomes inflamed (swollen) and infected. In many cases, an obstruction (blockage) within the appendix causes the infection, resulting in bacterial overgrowth. In 20 to 30 percent of children, the appendix ruptures and releases the infection into the abdominal cavity.
Because the appendix is located in the lower right portion of the abdomen, the most important symptom is low abdominal pain. This often starts around the belly button and moves to the lower right side later. Other symptoms include:
Appendicitis affects 80,000 children per year in the United States. It is most common in the second decade of life. Fifty percent of children will have a family history of appendicitis. Appendicitis is the most common cause for emergency abdominal surgery in childhood.
Ruptured appendicitis occurs in 30 percent of patients and is more common in children under five years old.
The main signs of appendicitis are a history of pain in the right lower portion of the abdomen followed by vomiting and low-grade fever, and tenderness and rigidity (stiffness) in the same area.
Most patients will have imaging of their abdomen with ultrasound and/or a computed tomography (CT) scan. Blood tests and examination of the urine may also be performed.
No one test or finding is 100 percent accurate and reliable in diagnosing appendicitis. The physician must piece together all available information. In some cases, the only way to diagnose appendicitis is to perform surgery.
The treatment is removal of the infected appendix with surgery. In some cases, when the appendix has already ruptured, surgery is done after a period of treatment with antibiotics.
The usual length of stay in the hospital is 12-24 hours for simple appendicitis, and 5 to 7 days for ruptured appendicitis. The child will receive intravenous (in the vein) pain medication and antibiotics during the hospital stay. Oral feedings are started slowly, usually starting with clear liquids. Your child will gradually advance to a regular diet. There may be a dressing over the incision.
Your child will be ready for discharge from the hospital when he or she can eat a regular diet, has no fever or drainage from the incision, and has normal bowel function.
Most children will need a few days of rest at home before returning to school, and 2 to 4 weeks before returning to gym and sports, depending on how much inflammation there is.
You may notice some minor swelling around the incision; this is normal. However, call your health care provider if your child develops any of the following:
A follow-up outpatient visit will be scheduled one to two weeks after your child's surgery. Your child's health care provider will examine the wound and evaluate his or her recovery.
© Copyright 1995-2017 The Cleveland Clinic Foundation. All rights reserved.
This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. This document was last reviewed on: 11/29/2016…#10792
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Guangzhou Baiyun Aluminum Factory Co., Ltd. was established on 16th June 1978, certificated by The Ministry of Construction of China, attached to Guangdong Aluminum Group.We are professional and experienced Engineering company, major in aluminum products, property acquisition, property leasing, import and export business. Guangzhou Baiyun Aluminum Factory Co., Ltd. currently
holds the "2 Level Metal Doors and Windows Engineering Contracting", "3 Level Building Curtain Wall Engineering Contract Professional Qualification" issued by MOC; and has independent import and export rights. Our company was also awarded by government authority with the honors: High Credit Enterprise Honorary Title of 2002 (for four consecutive years), consecutive five years of High Credit Enterprise Honorary Title after 2005. After years of efforts, innovation and constant transformation, Guangzhou Baiyun Aluminium Factory Co., Ltd. has been successfully transferred into Guangzhou GL Aluminium Co., Ltd. Company, in the provision of aluminum alloy goods, aluminum doors and windows, and building curtain wall engineering service. Our business has been extended to property acquisition, property leasing; and the service has been expanded to international market. We vigorously develop aluminum products processing and export service. Our sales network has spread all over China, Taiwan area, Hong Kong, Africa, Australia, South America, Russia and North America. After more than twenty years of persistent efforts, our company has extensive industry experience in the production and installation, cultivates a troop of skillful and professional technique workers, absorbs and trains a group of outstanding corporate management team. During the past 20 years, our company has introduced doors and windows processing machines from Germany Elumatec and a large number of advance equipment in domestic. The production capacity of our company is more than 160,000 square meters per year. Our company focuses on research and development and learns the good factors from others. We are maintaining the multi-channel cooperation with curtain wall companies and accessories experts of Europe, the United States, Hong Kong and other countries and regions. Thus we have developed a variety of high-performance building curtain walls, doors and windows. Our products mainly include energy-saving curtain walls, point-supporting curtain walls, framed curtain walls, unitized curtain walls, semi-unitized curtain walls, energy-saving and environmental protection aluminum doors and windows, metal and glass roofs, lighting houses, handrails, and other more than hundreds of series. Keeping the spirit of innovation, advancing with the guiding ideology of keeping pace with the time, with unique corporate culture and corporate image, excellent brand, as well as excellent product quality and service, our company has been supported by a large number of real estate developers, builders, and design institutes, constituting a long-term cooperation and powerful alliance, and joint development of a new prospect. The cases of our company: Zhaoqin New World Garden, Shaoguan Pasture Workshop, building of Zhuhai Coloplast (China) Co., Ltd., Huizhou Palm Island, Xingning Financial Building, Guangzhou University City and more.


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Djoko Susanto Net Worth: Djoko Susanto is an Indonesian entrepreneur who has a net worth of $1.17 billion. Born Kwok Kwie Fo in 1950 in Jakarta, Indonesia, he is the owner of Alfamart, a retail business with a concept of mini-marts. The sixth of 10 siblings, Susanto had to drop out of school after finishing one year of high school because the Government banned students with Chinese names to learn (Thus, he changed his name later). At the age of 17, he started to manage his parents' humble 560 feet food stall inside Pasar Arjuna. Then, Susanto started selling cigarettes and launching more stalls. His successful achievement captured the attention of cigarette mogul Putera Sampoerna, and together, they established more similar stalls, and then, the duo started a discount supermarket chain. After Sampoerna sold his cigarette business to Philip Morris, now Altria, including his part of retail business run by Susanto, Altria did not wanted the retail company, and several years later, Susanto managed to purchase the stake of the retail company, making him an owner of 65%. During the years, he developed the retail business into the minimart chain Alfamart that currently holds 7,717 stores under few brands like Alfa Midi, Alfa Express and Lawson.
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The Australian Tax Office is about to get a whole lot tougher on self-managed super funds, with its available weapons arsenal to punish wayward trustees set to be expanded from mid-year. And its broader weaponry makes more sense too.
Dare I say it, the new penalties are actually good news for self-managed super fund trustees.


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Why not us? Why not tonight?
Like many Germantown opponents have been thinking the last two seasons, Friday night in Whitefish Bay, the home Blue Dukes inquired once again if they could be the ones to end the Germantown winning streak. After all, the Blue Dukes are certainly familiar with the Warhawks, having accounted for several notches in the 58-game run prior to this latest battle, and Whitefish Bay hung with a tough Milwaukee King squad just last week.
Unfortunately for the Blue Dukes, the answers given by Germantown were familiar ones as senior guard Lamonte' Bearden led the Warhawks past Whitefish Bay, 80-72. Bearden, a University of Buffalo recruit, scored 29 and was the catalyst in a first-quarter run that cemented Germantown's 59th consecutive win. Brother Brian Bearden isn't too shabby either, helping out with 22 points of his own.
Whitefish Bay held an early 3-point lead before Germantown scored 16 unanswered, including two dunks (on four attempts). Lamonte' Bearden seemed to flip a switch during the run, becoming instantly more assertive and marking 15 tallies in the first quarter alone, giving Germantown a 27-17 lead. The multiple dunk attempts weren't exactly what Germantown coach Steve Showalter wants all the time, but he recognized the fact the plays sparked an important run.
"If we could stuff the ball better, it wouldn't be so bad, but we do want to make runs, and it did help," Showalter said. "Sometimes one or two runs in a game like this are enough, and we needed them to be able to hold these guys off.
"It's never fun to play at Whitefish Bay and I'm never surprised at how difficult it is when we come here."
When the Warhawks tried to run further away to start the second quarter, it was junior guard Isaiah Johnson who finally stemmed the tide with a 3-point basket four minutes into the period after Germantown led by as many as 14 points. Johnson's nine second-quarter points kept the Blue Dukes within 11 points at halftime.
A trio of buckets to open the second half pushed the Warhawks lead to a game-high 18 points before Whitefish Bay would again answer. The Blue Dukes' leading scorer on the early season, junior Miles Sigh, finally cracked the score sheet with five straight points and Germantown led just 58-51 after three quarters. The spark from Sigh along with a spirited fourth quarter just wasn't enough to claw back into the game for the Blue Dukes.
"You never say there are moral victories, but I was glad to see us battle back from down big and we were right there at the end," Whitefish Bay coach Kevin Lazovik said. "We believe that we can compete with anyone and we will go toe to toe with anyone."
With early-season loses to King and now Germantown, Lazovik spoke of what it has been like playing such a difficult early schedule.
"You want to test yourself and see how you stack up against the best, and those are two great squads," Lazovik said.
Germantown is now three wins shy of the 62-game winning streak put together by Whitefish Bay Dominican from 1977-80, believed to be the state record.
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- Germantown's baseball season ends with tough loss to West Bend West
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- Germantown's Keefe has fun, plays strong at WBCA All-Star game


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Oct 06 Notes, Quotes
MLB bags intentional walk to help shorten games
Sports Xchange
February 21 In a move that might save one minute every few games, MLB will no longer require pitchers to lob four pitches to issue an intentional walk, ESPN.com reported Tuesday, FULL STORY
Rubin: 5 teams that could challenge favored Cubs
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February 12 Since the moment when Kris Bryant gloved Michael Martinez' ground ball and threw across to Anthony Rizzo to end the Cubs' 108-year World Series drought last November, Chicago was installed FULL STORY
Report: MLB proposes intentional walk, strike zone changes
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February 06 Major League Baseball has made formal proposals to the players' union to make changes to intentional walks and the strike zone, ESPN.com reported Monday. FULL STORY
Mets bolster pitching staff, bring in Salas, Gorzelanny
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February 03 Salas posted a 2.08 ERA in 17 games with the Mets last season after being acquired from the Los Angeles Angels. FULL STORY
Cespedes lands $110 million deal from Mets
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November 29 After opting out of his contract with the New York Mets and walking away from $47 million guaranteed, Yoenis Cespedes will not change uniforms, agreeing to a four-year, $110 million contract to stay with FULL STORY


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Hotfrog INDIA provides information regarding Magnum Forge in Dist Pune Maharashtra. Magnum Forge is located at Gat No 776 & 777, Near Shindewadi Pune-Satara Road Tal Bhor, Dist Pune Maharashtra 412205 and provides Stainless Steel services. Contact them on +91 2113 252422 or by visiting them on their website http://www.magnumforge.in.
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text: Idist I've recently become very interested in intelligent design (ID), e.g. the works of Phil Johnson, Mike Behe, Wiliam Dembski, etc. I was just wondering what you guys thought about it. In a lot of ways these guys are very anti-evolution...but when creationism comes up they seem to either ignore the topic or just come out and say that they accept that the earth is billions of years old. Mike Behe says that he finds common descent reasonable in Darwin's Black Box. Dembski believes in an old earth: I do not regard Genesis as a scientific text. I have no vested theological interest in the age of the earth or the universe. I find the arguments of geologists persuasive when they argue for an earth that is 4.5 billion years old. What's more, I find the arguments of astrophysicists persuasive when they argue for a universe that is approximately 14 billion years old. I believe they got it right. Even so, I refuse to be dogmatic here. I'm willing to listen to arguments to the contrary. Yet to date I've found none of the arguments for a young earth or a young universe convincing. Nature, as far as I'm concerned, has an integrity that enables it to be understood without recourse to revelatory texts. That said, I believe that nature points beyond itself to a transcendent reality, and that that reality is simultaneously reflected in a different idiom by the Scriptures of the Old and New Testaments. http://www.discovery.org/viewDB/index.php3?program=CRSC%20Responses&command=view&id=534 ...but is less definite on common descent: More significantly for the educational curriculum, however, is that intelligent design has no stake in living things coming together suddenly in their present form. To be sure, intelligent design leaves that as a possibility. But intelligent design is also fully compatible with large-scale evolution over the course of natural history, all the way up to what biologists refer to as "common descent" (i.e., the full genealogical interconnectedness of all organisms). If our best science tells us that living things came together gradually over a long evolutionary history and that all living things are related by common descent, then so be it. Intelligent design can live with this result and indeed live with it cheerfully. But--and this is the crucial place where an ID-based curriculum will differ from how biological evolution is currently taught--intelligent design is not willing to accept common descent as a consequence of the Darwinian mechanism. The Darwinian mechanism claims the power to transform a single organism (known as the last common ancestor) into the full diversity of life that we see both around us and in the fossil record. If intelligent design is correct, then the Darwinian mechanism of natural selection and random variation lacks that power. What's more, in that case the justification for common descent cannot be that it follows as a logical deduction from Darwinism. Darwinism is not identical with evolution understood merely as common descent. Darwinism comprises a historical claim (common descent) and a naturalistic mechanism (natural selection operating on random variations), with the latter being used to justify the former. According to intelligent design, the Darwinian mechanism cannot bear the weight of common descent. Intelligent design therefore throws common descent itself into question but at the same time leaves open as a very live possibility that common descent is the case, albeit for reasons other than the Darwinian mechanism. What, then, are teachers who are persuaded of intelligent design to teach their students? Certainly they should teach Darwinian theory and the evidence that supports it. At the same time, however, they should candidly report problems with the theory, notably that its mechanism of transformation cannot account for the complex specified structures we observe in biology. But that still leaves Eugenie Scott's question, "What happened when?" There is a lot of persuasive evidence for common descent that does not invoke the Darwinian mechanism, notably from biogeography and molecular sequence comparisons involving DNA and proteins. At the same time, discontinuities in the fossil record (preeminently in the Cambrian explosion) are more difficult to square with common descent. To establish evolutionary interrelatedness invariably requires exhibiting similarities between organisms. Within Darwinism, there's only one way to connect such similarities, and that's through descent with modification driven by the Darwinian mechanism. But within a design-theoretic framework, this possibility, though not precluded, is also not the only game in town. It's possible for descent with modification instead to be driven by telic processes inherent in nature (and thus by a form of design). Alternatively, it's possible that the similarities are not due to descent at all but result from a similarity of conception, just as designed objects like your TV, radio, and computer share common components because designers frequently recycle ideas and parts. Teasing apart the effects of intelligent and natural causation is one of the key questions confronting a design-theoretic research program. Unlike Darwinism, therefore, intelligent design has no immediate and easy answer to the question of common descent. And somewhere I think read Dembski saying that ID even predicts common descent, but I couldn't find the article. Even Phil Johnson (who I think is a baptist), the father of the Intelligent Design movement, seems more anti-creationist than he used to be. Richard Dawkins recently asked him what he thought the age of the earth was: Q: Do you think the age of our planet is closer to 4000 million years or closer to 100,000 years? A: The former, but with the caveat that I have made no effort to investigate the subject personally and am merely accepting the current scientific consensus. In lectures, I tell the audience that I assume that the earth is about 4.6 billion years old. If Darwinists would like to have more time, however, I am happy to grant them 46 billion years, or 460 billion. Regardless of the time available, their system of evolution cannot work because it never gets started with the essential job of creating new complex specified genetic information. See my review of Paul Davies' book on the origin of life. http://www.arn.org/docs/pjweekly/pj_weekly_010709.htm Now, these ID people are very smart scientists and very devoted Christians also. But they think that Young Earth Creationism and the Flood (and therefore, a literal interpretation of Genesis) are wrong. YECs I know seem to like the ID people, but they seem to avoid talking about what the IDists think about YEC. Here's some resources about ID on the web: http://www.arn.org http://www.discovery.org HELEN I am part of the ID movement as well as part of the YEC camp. A few of us do both! ID is NOT creation-oriented at all, so it is a much wider umbrella, involving a wide variety of non-Christians and especially of non-YEC creationists. We are a distinct minority. My personal contribution is in helping with some research, proof-reading stuff, and keeping up with what is going on at the ID conferences. ID approaches the natural world from the point of view of science. For this reason they do not step over the theological threshold as a movement, although obviously the different contributors often do on their own. Phil Johnsons' "Wedge of Truth" published a year ago spends the last chapters showing how the God of the Bible is the only logical answer, for instance. But ID includes people who do not accept that, and Phil is friendly enough so that his views don't bother them. But the thrust of the ID movement is to present the same criteria that we would use when looking at the Golden Gate Bridge, for example, to determine whether or not it was designed or accidental, and apply that criteria to natural phenomena to see if there is indication of intelligent design or not. The two main tools ID has are called 'specified complexity' and what is now referred to as the 'Dembski filter.' Specified complexity refers to the idea that if something is complex by definition (and there are definitions here), and shows evidence that it is specifically purposed for one activity or function, then we need to look at it in light of a couple of other things. First, is this happening because of a natural law? If so, then ID will not assign the label 'intelligently designed' to it. An example here might be the lovely designs waves on a beach leave. Design, yes. But the waves and the sand were simply responding to the laws of physics and the patterns are what is left. Although the components parts, such as the laws may be considered to be intelligently designed, ID is looking for primary and immediate intelligent design. If what is being observed is not the product of a known law, then what are the chances of it happening serendipitously? A good example of that is rolling a hundred marbles across a wooden floor. There is a very good chance that somewhere along the line three of them will line up in a straight line. That cannot be considered intelligent design. But if it not there because of a known law, and if it defies the laws of probability, and if it demonstrates specified complexity, then it is certainly a candidate for the label of 'intelligently designed.' And this is where ID stops, philosophically. The designer is inferred but not specified. The purpose of the designer is never approached. Those are theological questions. Creation science comes at the issue from the other side. There is a paradigm which is accepted as presuppositional (God created everything. For Christians that means 'according to Genesis'), and data is interpreted within that framework. Thus the foundation for creation science is philosophical/religious, just as the foundation for evolution science is based on the philosophy of materialistic naturalism. So I like ID! I think it has something very valuable to offer simply because it is not based on the sorts of beliefs that both evolution and creation are. It is really interesting to me that the ID camp really does contain some non-theists and a good many evolutionists. I'm not sure what they do inside their heads when they reach the point of inferring intelligent design, but they sure are valuable people to have around -- keeps everyone else from going off the theological deep ends! One of the main criticisms I hear about the ID movement is that they are some kind of creationism in disguise. To me, that sort of comment smacks of incredible ignorance concerning what the movement is all about. The two systems come at natural phenomena from exactly opposite directions. IDist Thanks Helen! Perhaps you'll permit me a question... You said: And this is where ID stops, philosophically. The designer is inferred but not specified. The purpose of the designer is never approached. Those are theological questions. Creation science comes at the issue from the other side. There is a paradigm which is accepted as presuppositional (God created everything. For Christians that means 'according to Genesis'), and data is interpreted within that framework. Thus the foundation for creation science is philosophical/religious, just as the foundation for evolution science is based on the philosophy of materialistic naturalism. Perhaps I'm being too picky, but in that quote I posted of Dembski (who is definitely a Christian, I don't know if he's baptist like Phil Johnson) pretty much says that "I don't think Genesis is a science textbook" (that's not exact, I can't see my original post while typing here). You seem to imply that real Christians think it pretty much is, 'according to Genesis' as you say. So is Dembski not a real Christian, or are Christians free to not take Genesis literally? (at least, if the physical evidence seems to point against the literal interpretation, as the main IDists I've read seem to think, although they don't discuss it much) JIMMY HIGGINS The largest problem ID has is that it is not testable. If, in fact, it is true, that a god created the heavens etc... there is still no way to prove it. The second problem you'll run into is the god issue. Which god? Your god, islam's god, a hindu god, how about Zoroaster? Who's creation story? If one is going to teach the origins of the universe from a religious standpoint, it would be equally as ignorant as arrogent to choose only what christianity believes is the whole course of history. A problem that supporters of ID have is their continual belief that if you can't prove it, then it isn't necessarily so, however, our idea is just as good. Problem is, proving something to be true, believing something to be true, and supposing something to be true are not as closely linked as you'd think. Take molecular composition, FCC, BCC, etc... We have never actually seen the atoms in these positions, however it is widely accepted that they do exist in such a formation. Take bipolar compounds like water, or tetrahedrons such as sodium tetrachloride. We have never "seen" the actually shape they make, yet no one seems to dispute the shapes. ID followers make a poor distinction between what is believed to be true and what we may hypothesize is true. ID's feel that if it isn't proven then it is merely a thought. However, due to the ID's poor understanding of scientific responsibility, this is hardly the case. Take Einstein's "Theory" of Relativity. It's a theory, but the word theory has been bastardized by the unscientific. A word theory is rarely given to just a mere thought. A theory needs to be tested, as has Relativity, countlessly. Until all facets have been deemed true, does it become "Law". The Theory of Evolution hasn't been graced as easily with testable evidence. Evolution isn't testable with humans. The timeline is too long to test with. However, evolution gains legitimacy through past observation and fossil records. Granted certain "gains" in evolution have been proven false, however, to suggest that these instances outweigh the legitimacy of other gains is fool-hardy. That one finds it hard to believe that all life came from a unicelluar being is not justification for its dismisal as a fact. Einstein felt that way with blackholes. He felt that it was too hard to believe that blackholes could exist as his own theory disputed. However, they have been proven to exist. And this leads to the greatest paradox ID's create. How can life come from nothing? Atheists always will argue the counter. How can consciousness come from nothing? Life is indeed a wonderous effect. Whether created by some god or through nature is tough to prove. Even if it was through nature, it can still be assumed to have been a cycle of the mind of a god. However, this is all irrelevent because this isn't about science at all. This is about teaching Christian doctrine in school. For I hardly see Christian's calling for a Taoist or Islamic or Australian Aboriginal creation story of life. When christian's talk about Intelligent design being taught in school, they ARE ONLY TALKING ABOUT CHRISTIAN intelligent design. And then, how scientific is that, to only teach one religion in school? If religion is truly to be regarded as scientific, it must subdue itself to continuous scrutinization, the same thing science allows itself to be subjected to. I, however, don't see that in the future though. Religion will never allow itself to be scrutinized because of the fear that its foundation will be disturbed and its structure demolished, as many scientific ideas have fallen. JOHN PAUL The largest problem ID has is that it is not testable. Not according to the scientists who support ID. Is Intelligent Design Testable? http://www.discovery.org/viewDB/index.php3?program=CRSC%20Responses&command=view&id=584 There are already disciplines in place that rely on design inference- archeaology is one, investigating an alleged arson or murder, would be two others and then we have SETI. So as we can see design inference is already part of our lives. Expanding that to the biological field should not be so difficult. As a matter of fact such a thing is happening: Approaching Biology from a Different Angle http://www.arn.org/docs2/news/approachingbiology041701.htm ID is the future of biology, whether you want to accept it or not. HELEN IDist -- you asked some questions: Perhaps I'm being too picky, but in that quote I posted of Dembski (who is definitely a Christian, I don't know if he's baptist like Phil Johnson) pretty much says that "I don't think Genesis is a science textbook" (that's not exact, I can't see my original post while typing here). You seem to imply that real Christians think it pretty much is, according to Genesis' as you say. So is Dembski not a real Christian, or are Christians free to not take Genesis literally? (at least, if the physical evidence seems to point against the literal interpretation, as the main IDists I've read seem to think, although they don't discuss it much) First of all, Christianity is a matter of Jesus Christ. I know Bill and consider him a brother in Christ. Phil, by the way, is Presbyterian. From my own personal point of view, I am convinced that the Holy Spirit takes each of us who belongs to Christ and moves us bit by bit toward the full truth of everything in Christ. So we may find ourselves differing now about various things, but I know we won't later. I am quite sure I am wrong about a number of things. But I know the Holy Spirit is causing me to become less and less wrong as I mature in Him. Bill, Phil (sound's like Dr. Suess... ) and the rest are the same, I know. Phil just had a major stroke last July and seeing the way the Lord has worked with him through his recovery has been a major testimony to an awful lot of people and a point of real spiritual growth for Phil. Bill's dealings with Baylor threw him back to prayer and trust in the Lord very quickly, and he has grown through that and that, too, has been part of his life's testimony. So for all of us, who are Christians, it's a matter of growing and learning more and more. As far as Genesis goes, I think every Christian references to it. In what way is often different, but the reference is sort of universally there. That's the personal Christian side of my response. Now, the ID side....the side without reference to faith. ID'ers are not concerned with Genesis as part of ID. It simply is not relevent. What is relevent is the mathematical and scientific investigation of phenomena and the use of certain criteria to define it. That's what ID does. ID uses the same methods forensic science does. In the same sense you don't ask forensic science to prove itself worthy through 'testing' the entire paradigm, you can't ask ID to do that. Archaeology is exactly the same. What these areas of work do is to look at the evidence and sift through it and try to reach logical conclusions based on prior knowledge and prior evidence (experience) within a scientific framework. You can disagree with that sort of method, but it is not a matter of testing. Hypotheses are what you test! For instance, if an ID proponent or writer said something like "this round pile of rocks shows intelligent design", that can be tested via the methods forensics or intelligent design or archaeology all use. 1. Do the rocks appear in that sort of position as a matter of nature (law)? If the pile is at the foot of a mountainside and there is no discernable plan, purpose, or pattern to them, then the probably conclusion is that they were not intelligently designed in that formation. 2. Is there a high probability of the rocks being like that? If the answer to #1 has been no, that there is something about those rocks that seems to indicate design or purpose, or even simply pattern, then this second question is fair. This is where we would look to experience and probability matters. If there is a high probability that these rocks could have fallen into this seeming pattern or any other seeming pattern simply as a matter of chance, then intelligent design is not considered. 3. But if there is no natural law which explains this pile of rocks, and if the probability of them in this configuration is extremely low, then we can call in the concept of specified complexity. Is there a complex relationship among these rocks? If they are cemented together with mortar and there is a spray of water coming out of the middle and gathering in a small pool formed by those rocks, then we see complexity. Is the complexity specified? It appears so, yes, as the specification is to conduct water up to a certain place and then collect it for recycling in the pool. Now, when we look at a fountain, experience tells us that it was designed. Good or bad design is an entirely different question and involves certain judgments not even in the equation. The question was, is this pile of rocks designed to be the way it is here? So intelligent design is a method by which something can be tested. If you don't like the method, fine. But it will look at a flower, for instance, and ask, "did this come about by some natural law?" No. It did not. There is no natural law that demands a plant cell produce a cell of another variety and color and purpose. We see flowers at particular places on particular plants. Is a flower a high probability of what a plant cell will do? No, it is not. We don't see them popping up on leaves or bark. Is a flower complex? Yes, it is. It has a number of different internal parts which are interrelated to each other. Does the flower have a specific purpose? Yes, it does. Those parts work together to attract pollenizers and then produce a seed. This is specified complexity which does not fit the category of simply following a natural law (like gravity or thermodynamics), is unlikely to happen to a plant cell as a matter of chance, and exhibits specified complexity. Thus, a fair conclusion is that the flower is intelligently designed. That is what intelligent design is concerned with. Can we take the same criteria we use in other fields of science and apply it to nature? If not, why not? That's ID. It is not something you test. It is a method of testing you may or may not agree with. You can disagree with the testing done in forensics, too. That is a matter of your personal reaction. But the fact that it is a method of testing remains. Is it a strange 'bedfellow' with YEC? Yes and no, actually. If you consider ID as a very wide umbrella and YEC as a specific group inside that generalization that nature seems to be exhibiting intelligent design, then the fit is fine with YEC as a subgroup of ID. But if you are going to look at approaches to science, they tend to be different, as one approaches on a purely objective basis (much more purely, as a matter of fact, than evolution), and the other from the preconception that God created everything. In that sense they are very different. So it's all a matter of how one wants to look at it. Hope that helps. Eugenie Scott et al and the press have screamed that ID and creationism are the same and so some believe that. But they simply are not. If they were, probably at least 3/4 of the people who are involved in ID would disassociate from it quite publicly. JIMMY HIGGINS Re: John Paul's linked article, {I]Is Intelligent Design Testable?[/I] I must remark that the article linked above was rather unsupportive to its own claims. Within itself, it stands tosay ID as a theory is falsifible, confirmable, and predictable. However, the article never really explains how, or worse yet holds the fate of other theories as proof of how the ID ranks as a scientific theory. In fact, I must say the article's take on how the ID argument is falsifible is humorous. The article proclaims that the inability of Darwin's theory to explain the Bacterial Flagellum is what is evidence of for ID. Somehow Darwin's own falsibility becomes ID's ability to be falisible, which is utter nonscence. I have yet to witness one committed Darwinist concede that any feature of nature might even in principle provide countervailing evidence to Darwinism. In place of such a concession one is instead always treated to an admission of ignorance. Thus it's not that Darwinism has been falsified or disconfirmed, but that we simply don't know enough about the biological system in question and its historical context to determine how the Darwinian mechanism might have produced it. Strangely, the same defense that theists use for why hardly any records exist on Jesus' Crucifixion or Moses' Exodus is not viable to the scientific community. Only their own. I move on to Confirmation. The article does accept that short-term gains in a species can and do exist. However, they argue the method in which these changes occur and completely deny any large scale changes. Then the article goes into a huge irrelevent tangent dealing with my second favorite movie of all-time, Contact. Although in the actual SETI program (Search for Extraterrestrial Intelligence) radio astronomers look not for something as flamboyant as prime numbers but something much more plebeian, namely, a narrow bandwidth of transmissions (as occur with human radio transmissions), the point nonetheless remains that SETI researchers would legitimately count a sequence of prime numbers (and less flamboyantly though just as assuredly a narrow bandwidth transmission) as positive evidence of extraterrestrial intelligence. No such conclusive signal has yet been observed, but I can assure you that if it were to be observed, Eugenie Scott would not be complaining about SETI not having proposed any "testable models." Instead she would rejoice that the model had been tested and decisively confirmed. Not strangely, the author is so far off-base that I can barely contain my composure. If a signal that contain prime numbers were to be pumping through space, it is not failed logic to believe that it is extraterestrial. In fact, it would be obvious. However, the author omits the fact that when pulsars were first discovered, scientists believed that the signals were being sent by an alien race, because of the time precision of the signals being sent. However, this died off when it was learned that pulsars work better than clocks at keeping time. Now if we were to hear prime numbers, there would be no other reasoning for the signal than extraterestrial because no such signal could exists in nature. The author then goes on to say that if aliens were to blast mathematical equations well beyond our means, we'd dismiss it because of its complexity we could understand. However, such a conclusion is wrong. If there is a signal, there is a signal, and if it is chaotic, it is always chaotic and that is sign enough of contact. Just because they wouldn't have been able to understand it, doesn't mean the connection wouldn't be there. Worse yet, this is about confirmation. What the author is seemingly trying to say is: 1) We see a process 2) We don't understand it fully 3) However, it is complex and complete Conclusion, it is a complex and complete process and must be from an Intelligent Designer. Rather than exposing ignorance to the subject, they make a hasty conclusion, just as people once did with disease being caused by demons etc... Rather than actually being a scientific find, the ID really is is a vault of unidentified processes that are complex. The ID confirms that 1) The complexity, and 2) the unknown origin of a process. There is NO ID testibility that will confirm an Intelligent Designer. This, the author decides to omit. Onward to predictability. The author saves the best for last here by claiming that ID is not predictable, but there is a good reason for it. But what about the predictive power of intelligent design? To require prediction fundamentally misconstrues design. To require prediction of design is to put design in the same boat as natural laws, locating their explanatory power in an extrapolation from past experience. This is to commit a category mistake. To be sure, designers, like natural laws, can behave predictably (designers often institute policies that end up being rigidly obeyed). Yet unlike natural laws, which are universal and uniform, designers are also innovators. Innovation, the emergence to true novelty, eschews predictability. Designers are inventors. We cannot predict what an inventor would do short of becoming that inventor. Intelligent design offers a radically different problematic for science than a mechanistic science wedded solely to undirected natural causes. Yes, intelligent design concedes predictability. But this represents no concession to Darwinism, for which the minimal predictive power that it has can readily be assimilated to a design-theoretic framework. The theory, or should I say, LAW of gravity is predictable. Take two objects. Drop them from the same height. Excluding wind resistance, the objects will land at the same time. This was proven on the moon. The Law predicts it! This is what science means by predictability. The author states, is predictable, but because the Creator is willing to change things on a whim, this will lead to unpredictability. There is NO predictability in ID because the theory itself allows for a wild card. Such a play in evolution would be used against itself by ID'ers, however, the ID'ers most favorite song must be 2 out of 3 ain't bad. The ID, as true as it might be, is not a valid scientific theory. It is a metaphysical theory because it relies on too much. 1) Falsible? No. Can not disprove the existence of god. 2) Confirmable? No. Can not prove the existence of god. All that ID can confirm is the complexity of life. This is hardly an estounding conclusion. It's been known for a while. 3) Predictable? Certainly not. It is already inconclusive if a Creator exists. If a creator does exist, it is then impossible to predict what the creator will do. The article admits as much. Because all three fall out of touch with the ID, there is nothing the ID can give to science. Rather the ID will have to stay as a metaphysical ideal that can only be proven by the great creator itself, if it so chooses, which we can't even predict that it would.


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April 8, 2012
By Gavin Davis
Athletic Media Relations
Next on the tee
The Colorado State men's golf team is headed to Scottsdale, Ariz., for the 10th annual Cowboy Classic hosted by Wyoming Monday and Tuesday. The 54-hole tournament will be played at the Talking Stick Golf Club's North Course. Two 18-hole rounds will be played on Monday followed by the final 18 holes on Tuesday. Each day will begin at 8:30 a.m. MT.
The field
The 23-team field will be made up of Wyoming, Colorado State, Arizona State, Texas Tech, Boise State, Nevada, Wichita State, Colorado, UC Davis, Kansas State, Air Force, Northern Colorado, New Mexico State, Santa Clara, Old Dominion, Cal State Northridge, Gonzaga, San Diego, UC Santa Barbara, Weber State, Utah State, Kansas and Arizona.
The course
Talking Stick Golf Club's North Course is par 70 stretching 7,133 yards. The Course was in Golf Magazine's "Top 100 You Can Play" and ranked No. 1 in the state by Golfweek.
Rams Lineup
Zahkai Brown, Kirby Pettitt, Mike Sorenson, Michael Wuertz and Cameron Harrell will be swinging for Head Coach Jamie Bermel in Scottsdale this week. The Rams placed third in last season's outing including a second place finish by Brown and a 23rd place finish by Pettitt. Sorenson also has experience from last season's tourney. The Rams are looking to Improve from the 14th place finish at the Thunderbird Invite Saturday. Live scoring will available on GolfStat.com.
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Rams currently ranked No. 27 according to Golfweek, nine teams in field in top 100 nationally
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Olive oil
Olive oil contains essential nutrients and antioxidants that can clean numerous skin problems including stretch marks. Just warm up some olive oil and massage it into the marks to improve the blood circulation in the area and reduce their appearance. Before rinsing off with lukewarm water, leave the oil to work for half an hour and provide your body with vitamin A, D and E.
Aloe Vera gel
Fresh Aloe Vera gel can heal the small tears in the skin and restore its elasticity, which are the main causes of stretch marks. Just open up an Aloe leaf and remove the gel from the inside, then use it directly on the marks. Rinse the area with warm water in about 2 hours and repeat the process every day for best results.
Source: www.newdailyrecipes.com


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In Reply.
—I plead guilty for offering a "naive" proposal to the US-Cuba relations problems as indicated by Dr Huertas and Dr Martin. Apparently, I am just as naive to believe that my medical colleagues would show more concern for the health of the Cuban people, which is the focus of my argument, than about Castro's fate.I indicated in my article that the embargo is not the only cause of the Cuban people's deteriorating health status, and of their ability to purchase medicines at a fair price. As emphasized by Dr Kirkpatrick, however, the embargo certainly plays an important role. I also suggested that the Helms-Burton Act1 would only aggravate the situation and be, in the long run, counterproductive.Following the downing of the 2 planes on February 24, the Central Committee of the Cuban Communist Party held a session in which it called for strengthening ideological and
Chelala C. Medicine and the US Embargo Against Cuba-Reply. JAMA. 1996;275(21):1634. doi:10.1001/jama.1996.03530450023015
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The Global Acrylic Adhesives market was valued at USD 9.8 billion in 2014 and is projected to reach USD 13.45 billion by the end of 2020, growing at a CAGR of 5.4% during the forecast period from 2015 to 2020. Acrylic adhesives are manufactured using acrylate monomers and methacrylate as prime feedstock. Polymer mixtures are dissolved with either of the two aforementioned feedstock to manufacture two different components. One component consists of amines and metal salts acting as reducing agents and the second component consisting of oxidizing agents primarily peroxide components. These components can either be applied separately on two surfaces which are to be glued or can be mixed before application of the surface.
Request a sample report @ https://www.wiseguyreports.com/sample-request/364499-global-acrylic-adhesives-market-segmented-by-product-type-end-user-industry-and-geography-trends-and-forecasts-2015-2020
Acrylic adhesives, owing to their eco-friendly and low-toxic nature; high productivity i.e. heat accelerated and fast rate of cure; and high performance i.e. high impact and temperature resistance, is becoming an integral part of various commercial and industrial sectors. In the Acrylic Adhesives market report, we have taken the following major end-user sectors into consideration: Automotive, Construction, Packaging, Furniture, and Others. The Automotive segment accounted for more than XX.XX% share of the Global Acrylic Adhesives market in 2014.
This market is driven by a number of factors, such as growing automotive industry, dynamic economic development in the Asia-Pacific Region, and accelerating demand from packaging industry. However, this market faces certain drawbacks, such as volatility in the raw material prices, and stringent environmental regulations implemented by the governments across the globe. These factors may act as a roadblock to the growth of the market.
The Global Acrylic Adhesives market, on the basis of product type can be broadly segmented into solvent based acrylic adhesives, water based acrylic adhesives, and others. Water based acrylic adhesives is expected to be the fastest growing segment in the market, owing to its increasing use for the replacement of high-VOC emitting solvent-borne adhesives.
The market has also been geographically segmented into Asia-Pacific, North America, Europe, South America, and Middle-East and Africa. In terms of consumption in 2014, APAC led the market with a share of XX.XX%. It was followed by North America. With the improvement in the financial status of the consumers, the purchasing power of the middle class consumers has increased, which in turn is accelerating the demand for automobiles and buildings in the Asia-Pacific region, in turn making the region an area of immense potential and opportunities. However, the lack of or lax regulations regarding VOC in the region has considerably hindered the growth of this market.
Furthermore, the recovering construction industry in the European region will offer numerous opportunities in the growth of the European Acrylic Adhesives market, in turn driving the Global Acrylic Adhesives Market. Some of the major companies dominating this market for its products, services, and continuous product developments are 3M, DuPont (E. I. du Pont de Nemours and Co.), Sika AG, Dow Chemicals, Hernon Manufacturing Inc., and Avery Dennison.
Key Deliverables in the Study
1. Market analysis for the Global Acrylic Adhesives Market, with region specific assessments and competition analysis on global and regional scales
2. Market definition along with the identification of key drivers and restraints
3. Identification of factors instrumental in changing the market scenarios, rising prospective opportunities, and identification of key companies that can influence this market on a global and regional scale
4. Extensively researched competitive landscape section with profiles of major companies along with their market shares
5. Identification and analysis of the macro and micro factors that affect the Global Acrylic Adhesives market on both global and regional scales
6. A comprehensive list of key market players along with the analysis of their current strategic interests and key financial information
7. A wide-ranging knowledge and insights about the major players in this industry and the key strategies adopted by them to sustain and grow in the studied market
8. Insights on the major countries/regions in which this industry is blooming and to also identify the regions that are still untapped
Complete report details @ https://www.wiseguyreports.com/reports/364499-global-acrylic-adhesives-market-segmented-by-product-type-end-user-industry-and-geography-trends-and-forecasts-2015-2020
Key points in table of content
1. Introduction
1.1 Description
1.2 Research Methodology
1.3 Report Outline
2. Executive Summary
3. Market Overview
3.1 Current Market Scenario
3.2 Supply Chain Analysis
3.3 Industry Attractiveness – Porter's 5 Force Analysis
4. Market Dynamics
4.1 Drivers
4.1.1 Increased Demand for Water-based Acrylic Adhesives
4.1.2 Accelerating Demand from Packaging Industry
4.1.3 Dynamic economic development in Asia-Pacific
4.1.4 Growing Global Automotive Industry
4.2 Constraints
4.2.1 Volatility in Raw Material Prices
4.2.2 Stringent Governmental Regulations Regarding Disposal
4.3 Opportunities
4.3.1 Recovering European Construction Industry
4.3.2 Development of bio-based products
5. Market Segmentation and Analysis
5.1 By Product Type
5.1.1 Water-based Acrylic Adhesives
5.1.2 Solvent-based Acrylic Adhesives
5.1.3 Others
5.2 By End-User Industry
5.2.1 Automotive
5.2.2 Construction
5.2.3 Furniture
5.2.4 Packaging
5.2.5 Others
6. Regional Market Analysis (Market size, growth and forecast)
6.1 Asia-Pacific
6.1.1 China
6.1.2 India
6.1.3 Japan
6.1.4 South Korea
6.1.5 Australia & New Zealand
6.1.6 Rest of APAC
6.2 Europe
6.2.1 Germany
6.2.2 United Kingdom
6.2.3 France
6.2.4 Italy
6.2.5 Rest of Europe
6.3 North America
6.3.1 United States
6.3.2 Canada
6.3.3 Mexico
6.3.4 Others
6.4 South America
6.4.1 Brazil
6.4.2 Argentina
6.4.3 Rest of South America
6.5.1 Saudi Arabia
6.5.2 South Africa
6.5.4 Rest of MEA
7. Competitive Landscape
7.1 Mergers & Acquisitions
7.2 Joint Ventures Collaborations and Agreements
7.3 Market Shares Analysis
7.4 Strategies Adopted by Leading Players
8. Company Profiles
8.2 Icon Group
8.3 3M Co.
8.4 Xalapa
8.5 Avery Dennison Corp.
8.6 Dow Chemical Co.
8.7 ADCO Global Inc.
8.8 Sika AG
8.9 Ashland Inc.
8.10 Illinois Tool Works Inc.
8.11 H.B. Fuller Co.
8.12 RPM International Inc.
8.13 Adhesives Research Inc..
8.14 Beardow & Adams (Adhesives) Ltd
8.15 Chemence, Ltd.
8.16 Henkel AG & Company, KGaA
8.17 Huntsman Corp.
8.18 Pidilite Industries, Ltd.
8.19 Mapei Spa
8.20 Super Glue Corp.
8.21 Rohm and Haas Co.
8.22 Ninghai Dingcheng Adhesive Co., Ltd.
8.23 American Biltrite, Inc.
9. Disclaimer
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Quick Look
Property brokered by
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Property DetailsThis peaceful 3 bedroom 2 bath beach house is offered fully furnished and ready to be your home. Beautiful views of the Gulf of Mexico and the Mississippi Sound are available from the front porch and every room. All appliances to remain, this home has never been on a rental program and has been very well maintained. Several extras to include custom hinged plantation shutters for when you want all of the sunlight to shine in. Seller is offering a one year full home warranty to include all appliances, electrical, plumbing, AC and duct work. Call today for your personal showing!
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Additional Property InformationThis single family listing located at 2311 Island Shores Dr, Dauphin Island, AL has three bedrooms and two bathrooms. A beach house style property, it is currently priced for Upon Request.
Highlights include patio,deck.
This property is presented by Roberts Brothers Inc. based in Alabama.


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Smart Track Station
Guide price: £18
Last updated on 14th Dec 2009
Smart Track Station
The track reader engine slows down and stops at the station. Hear the authentic station announcements and railway sounds until the big engine starts up and sets off again. Children learn coordination by combining Smart Track rails with the rest of the track, and figuring out how to trigger the different functions. Compatible with the Brio Wooden Railway System.
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XSSecure Kids Security GPS Tracker Watch XS50J
1. Locating: GPS+AGPS+LBS Locating 2. Conversation Features: Two-way Phone call, voice record, and one-way SMS 3. Monitoring: Remote Monitoring, Sleep Monitoring, Remote shut down 4. GEO Fence, Emergency SOS 5. Alarm: Take off Alarm , Date/Time display, Alarm, Low power management 6. Disturb-free time setting: 3 sets of display clock, free Switch 7. Step: Activity tracking, Pedometer and consumption calculation


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Native indian jewelry
Explore related topics
Native Indian Jewelry
Boho Turq Cuffs 1900 - 1940 Native American #turquoise #boho
American Native Indian Jewelry
Turquoise jewelry
Huge Navajo Sterling & Nevada Slab Turquoise Necklace
Navajo necklace, with strand of silver beads suspending an elaborate naja incorporating turquoise and spiny oyster bezels.
Navajo Jewelry | Native American jewelry of the Southwest
Jewelry Cuff inspired by Native American jewelry. Would be great if it were sterling and turquoise - cut the rhinestones and sub with coral or spiny oyster.
There are so many resources available to help you get started. You can buy the supplies almost anywhere, charms, beads, dangles, special clasps plus much more. It does take quite a bit of practice, but it can be a fun hobby or even a career if you perfect it. If you have a large collection of fashion jewelry, make sure to only clean them with a damp cloth. Using polishing cloths or jewelry cleaning liquids... FULL ARTICLE…
Native American Jewelry - Hopi style overlay design with a turquoise stone in the center pendant. Mary and Everett Teller are a designer team currently living on the Navajo Indian reservation near the Four Corners.


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Top dolour
Americans aren't just taking over our football clubs, they are moving in on our professional academic institutions as well. Until recently the Professional Services Management Centre at the Saïd Business School, University of Oxford, was generously sponsored by Clifford Chance. That deal has ended (maybe for obvious reasons?). Instead, the funding is now coming from Novak Druce, a Texan IP niche firm run by Gregory Novak, a Saïd MBA alumnus. So it is now the Novak Druce Centre for Professional Service Firms.
Nothing against US law firms but this is a bit humiliating. Surely the true-Brit — and


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Kisses + Disses : Captain EO
Last Saturday I celebrated my birthday and the day couldn't have been better. The entire week was devoted to what JD called BIRRRRTHDAAAAAY EXTRAVAGAAAANZA! And he says it just like that. It's rather odd, but I deal with it because it's filled with twists and surprises leading up to my big day. On Saturday, we arrived at Disneyland just before sunset and I squealed like a little girl. It's been years since I've been to the Magic Kingdom, but it was just as special as I remembered as a kid.
We spent the evening eating every bad thing in sight (churros! pineapple ice cream! funnel cake! I'm on a sugar high!) and mapped my favorite rides before the fireworks show. On top of my list was seeing Captain EO. Oh, yes, the 3D short film starring Michael Jackson. I dragged JD into the theater donning our yellow glasses and sang the songs before it started. JD tried shushing me, but this only encouraged moon walking to my seat.
It was then I confessed to JD I saw Captain EO eight times when I was a child. In one day. I memorized the choreography and my mom even bought me the Captain EO shirt…which I wore only on the most special occasions. Watching the film years later rekindled the fondest memories…and I was happy to dance along in my seat like I was a kid again.
The only thing that would've made the day complete would have been JD joining me for a robot rendition of We Are Here to Change the World, hip thrusts and all.
This leads me to another installment of Kisses and Disses…
This week's DISSES go to…
*My inability to track down a Captain EO t-shirt (no, really, I'd wear it tomorrow if I could…it's cute…honest).
*My lack of will power. Birthday Extravaganza proved to disastrous my dietary regime.
*Falling asleep. It takes half an hour at night, half a second in the morning.
This week's KISSES go to…
*Breville Juicer. My family gave me a juicer for my birthday and I'm smitten. I feel healthier just looking at it. Tried it for the first time yesterday and the clean up process was pretty awesome and the juice (kale, spinach, apple, beets, ginger, and ginger) was ahhhhmazing. Oh no, I'm starting to talk like JD.
*Milani Liquid Eye Pencil. This pencil eyeliner is from Target and perfect for a dramatic evening out. It's creamy, so I set it for a smoky eye and I adore it.
*RDIO.com. I love this site and I've downloaded the app. It's like Pandora, but you can stream an entire record…and there's no commercials!
Happy Tuesday!
Comment with Facebook
April 9th, 2013 at 1:24 pm
Happy Birthday, Jasmine!
April 9th, 2013 at 1:38 pm
You don't know me from Adam's housecat, but I love Disney! I went on a search to see if I could find a tshirt for you. Here's an adult small opening weekend t: http://www.ebay.com/itm/Disney-Captain-EO-T-Shirt-1986-MINT-/200913585904?pt=LH_DefaultDomain_0&hash=item2ec76206f0
And here's a large. For $100! Good heavens, LOL: http://www.ebay.com/itm/VTG-MICHAEL-JACKSON-DISNEYLAND-CAPTAIN-EO-SHIRT-1986-L-/350752612522?pt=Vintage_Unisex_T_Shirts&hash=item51aa7c20aa
So glad you had a happy birthday extravaganza!
April 9th, 2013 at 3:28 pm
Joyeux Anniversaire Jasmine !
Maïeva Voyage
April 9th, 2013 at 3:29 pm
There's only 8 left!
April 9th, 2013 at 3:30 pm
April 9th, 2013 at 3:38 pm
*I* about squealed like a little girl when you said you went to Disneyland. Melissa and I are smitten with that place!!
When you go back, go to CA Adventure and get a hot-link corn dog.. Ermahgerr! Yes, it's everything horrible, just drink some kale before bed. Totally worth it!
"You can stream an entire Record." You DO like Captain EO don't you? 🙂
April 9th, 2013 at 3:43 pm
This is the perfect post first thing in the morning. Thank You so much for sharing. Kisses and Disses – Love it.
April 9th, 2013 at 3:52 pm
I have been looking for an excuse to go to disney world for awhile now its been 20 years! So glad you guys had such a fun tme
April 9th, 2013 at 4:46 pm
Try E-Bay for the shirt! Disneyland was selling them about 2 years ago during the summer. They were only men's sizes but my fiance rocks it like non other 🙂
Happy Belated Birthday!
April 9th, 2013 at 4:53 pm
Happy Belated Birthday! I haven't been to Disneyland in yearrsss. I'm glad you had fun! Btw…this may sound totes weird, but I love when you mention beauty products you love. You just always look sooo perfect and I'm always curious what products you use.
April 9th, 2013 at 4:58 pm
Check out this Captain EO shirt! 🙂
April 9th, 2013 at 5:40 pm
This is kind of totally random, but can I just say: I looove your outfit! It's just all cool & hip, so effortlessly — I would totally be geeking it up in Disneyland :D!
April 9th, 2013 at 5:43 pm
My own "kiss," to you… my husband and I were at Disneyland on Saturday, celebrating our two daughter's 3rd and 6th birthdays. We had just gotten off the Autotopia ride, and my husband, a photographer by hobby who follows many AMAZING photographers, spotted you and JD walk by. I wanted to dash after you to express my sincerest thanks, as you have truly inspired my husband to be more creative behind the lenses and follow his photography dreams on his own accord. He wouldn't let me, ;), and just wanted you to enjoy your evening without his kooky wife intervening! So I will say thank you now, as it REALLY was you, and wish you a happy birthday, and tell you that spotting you was an added bonus to a day that had already been so magical for us as a family!
April 9th, 2013 at 5:53 pm
I wanted to include my email address! 😉 Forgot to do so in my previous comment re: Disneyland before I pushed save.
Thanks again!
April 9th, 2013 at 6:08 pm
Belated happy birthday!!! Glad you had an amazing birthday, and don't worry- any calories consumed on your birthday dissipate: they never count 😉 also, I LOVE rdio! Best music app ever!
April 9th, 2013 at 11:02 pm
I just sold my Breville Juicer as I didn't use it as much as I expected. But I loved it.
April 10th, 2013 at 1:47 am
O-M-G. I totally saw Captain EO when I was a kid. Aaaaaaand I had the shirt (yes, unfortunately that was said with past tense). I remember standing in line and getting all excited to see things coming at me off the screen.
April 10th, 2013 at 2:53 am
Juicers are awesome. I look forward to seeing all your juice recipes and food displays.
April 10th, 2013 at 5:51 am
happy birthday
April 10th, 2013 at 3:05 pm
It was all the ginger that made your juice so ahhhhhmazing. 🙂
April 11th, 2013 at 7:22 am
i just ordered the same juicer!! can't wait to try it when we get back from australia!
April 14th, 2013 at 1:22 am
Just catching up on all your amazing posts from last week! Love that you went to Disneyland! I've never seen the Captian EO show, so I'll def check it out next time I go! And so glad you like the Breville Juicer! I've been thinking about getting one for some time…..
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The board of education, faculty, staff, administration, and parents of the Chestnut Ridge school district are all dedicated to providing an exceptional educational environment for our children. We are committed to fostering a love of learning, inspiring academic excellence and focusing on success for every child.
We have an immediate need for substitute cafeteria staff. Please inquire with Ron Mash at 814-839-4195 ext 2510, if interested.
We have a confirmed case of Pertussis (Whooping Cough) at CRMS. Please see the two links below for more information. Letter to Parents and Letter from PA-DOH
There will be a parent and community meeting on February 21 at 5:00pm in the Middle School Library. The meeting will provide an opportunity for the board to address any questions or concerns regarding the invitation extended to Chestnut Ridge to join the Laurel Highlands conference. If you have any questions please email them to Richard Emerick Athletic Director. at email@example.com
District Volunteer Clearance Info and FAQs
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text: A major search has been launched after a fisherman went into the sea at Kerryhead off the north Kerry coast this afternoon. The Chinese man is understood to have gone into the water at about five to three. Valentia Coastguard, Shannon Rescue 115 and the naval vessel the LÉ Orla as well as a number of other search and rescue teams are taking part in the operation. At this stage it's not known how the man who's Chinese came to enter the water. +++


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Tack Racks & Hardware
Narrow Your Results
Add more holding capacity to your Swinging Rug Rack with Three Arms by installing the Single Replacement Rug Rack.
The Replacement Wall Piece for the Swinging Rug Rack mounts on the wall. Swinging arms not included.
The Mesh Hay Bag is made from woven polyester yarns for breathability, strength and durability. This hay bag allows air to circulate, preventing moisture build up as it reduces hay waste lost to trampling. Hangs easily in stalls and trailers.
This Classic Equine® Top Load Hay Feeder is easy to fill with two to three flakes of hay. Made of tough poly for durability, it allows your horse to pull only small mouthfuls of hay at a time so hay lasts longer and waste is reduced. Hangs easily virtually anywhere.
This Brass & Wood Bridle Bracket is an elegant way to organize your tack room. The curved top maintains the shape of the bridle's crown without creasing or bending.
Brass double horseshoe hook. Sturdy enough to hold bridles, martingales or other essentials. Includes 4 matching brass screws for installation. Measures 4"H x 5".
The Freedom Feeder® Mini/Trailer Size makes your horse's hay last as he eats through its small openings. This original slow feed hay net simulates natural foraging and optimizes your horse's digestion.
The Brass & Wood Hook is a sturdy and attractive addition to your tack room to catch just about anything that needs to hang neatly.
The Deluxe Hay Net Bag is so easy to fill you'll enjoy using it daily. This hay bag keeps your horse busy and eating slowly through its small mesh panels on front and back. The perforated fabric base and sides allow water to escape.
The Corner Feeder Bag hangs in your trailer with an adjustable chain and double end snaps. This feed bag has a tough Cordura® shell and measures 24" x 23" x 12".
The Supa Drying Rack eliminates the need to dry your tack on a flimsy rack made for home use. This sturdy rack is meant for the stable with a capacity to hold up to 18 saddle pads, horse boots and multiple blanket. Easy to assemble, easy to store and easy to take on the road, the Supa Drying Rack provides four bars on each side for drying items.
Apple Picker's Knock Down Three-Arm Blanket Rack is easy to mount and strong enough to hold multiple heavy horse blankets. This black rack is made of heavy steel tubing and sturdy iron brackets. Easy assembly required.


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Free personalized radio that
plays the music you love
Chaos Theory
Features of This Trackhouse roots
four-on-the-floor beats
danceable beats
straight drum beats
a repetitive song structure
a rhythmic intro
use of modal harmonies
emphasis on instrumental performance
a bumpin' kick sound
subtle use of staccato synths
effected synths
a highly synthetic sonority
thickly layered production
trippy soundscapes
prevalent use of groove
and many other similarities identified in the Music Genome Project
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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text: @yjeu I'm sure you'll be able to go to the local hospital to have the intralipid done, Warren doesn't do it personally anyway. I do intralipid for elevated NK Cells. I had mine done 7 days before EPU, then at EPU...didn't have them at transfer, but if I'd been positive I would have had them again then and then as @Gagingi said every 7 to 10 days up until 12 weeks.


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Mulvane and Derby fire crews to create joint water rescue team
Two small Kansas fire departments have joined forces to create a swift-water rescue team.
Two small Kansas fire departments have joined forces to create a swift-water rescue team.
A school's future is up in the air as Newton school board members consider raising new money for the district through a bond issue.
Precise, intense and tireless were a few words used to describe Kansas State coach Bill Snyder Monday.
Great Bend is hoping that a three-year federal grant will help boost its number of firefighters.
The department does not know who specifically was targeted by ICE.
Kansas lawmakers are considering repealing the death penalty but a committee chairman is not sure whether the bill will pass.
The U.S. Marshals Service is requesting help from the public to locate a man with an arrest warrant.
Great Bend police are investigating two drive-by shootings. The shootings happened over the weekend.
The company will host two job fairs. The fairs will be on Monday, February 20 and on Friday, March 17 from 10 a.m. to 2 p.m
Reno County authorities responded Monday afternoon to SYT USA in Yoder, due to a carbon monoxide leak.
A federal judge rejected an emergency order halting construction of the remaining section of the Dakota Access oil pipeline.
Jeffrey Sandusky is the adopted son of Jerry Sandusky, the former Penn State football coach who was convicted of child sex abuse.
A proposed bill would compensate wrongfully convicted people in Kansas $80,000 for each year served in prison.
Sears and Kmart have evicted "a very small number" of Trump-branded items from their online stores.
Authorities investigating a suspicious death at a Salina apartment complex said that foul play was not suspected in the incident.


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Mini Viewing Cabinet Produces BIG Results!
The M-10MP mini viewing cabinet is also excellent for viewing TLC plates and for quality control inspection of PC boards. Weighing only 4 lbs. (1.8 kg), it can be conveniently carried from place to place. With its compact dimensions of 8.75W x 10L x 4.5"H (22.2W x 25.4L x 11.4 cm H), this space-saving unit can fit easily in cramped areas.
The CM-10MP is made of molded, high-impact plastic for rugged durability. It features a contoured eyepiece with a built-in UV-absorbing window for safe viewing.
Openings on top of the cabinet accommodate one or two MiniMAX™ Series UV lamps. Simply place the cabinet over the lab samples being examined, turn on the UV lamps and observe the bright fluorescent response. MiniMAX™ lamps are available in three models—UV-5A for long-wave UV (365 nm), UV-5F for short-wave UV (254 nm) and UV-5NF for a combination of both long- and short-wave UV emissions.
For more information about the Spectroline® CM-10MP mini viewing cabinet, call toll-free 1-800-274-8888. Outside the United States and Canada, call 516-333-4840. Website at www.spectroline.com.


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FDA approves Merck's lung cancer drug as first-line treatment
Merck & Co Inc said the U.S. Food and Drug Administration has approved its immunotherapy Keytruda for use in certain previously untreated lung cancer patients, making it the only approved first-line treatment.
The drug has been approved for treating metastatic non-small cell lung cancer (NSCLC) patients with high-levels of a protein known for suppressing the immune system called PD-L1, according to Reuters.
Keytruda works by taking the brakes off the immune system by blocking the interaction between PD-L1 and another protein, PD-1. The drug has already been approved for patients who have undergone previous chemotherapy for advanced non-small lung cancer.


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Good for business Boutique & Romantic Hotels in Lisbon, Lisbon, Portugal
Sort by price: Lowest | Highest
As Janelas Verdes
Atmospheric Lisbon hotel with great views of Portugal's capital
The As Janelas Verdes (translated as the Green Windows) is a small 18th centur...
Bairro Alto 3 Bedrooms Apartment
The Bairro Alto – During the day it is an "ordinary", historic district in Lisbon. Once the dusk is falling, it seems like whole Lisbon is as...
Dear Lisbon
Located in the heart of Lisbon, Dear Lisbon's is set on the historical neighbourhood of "Santa Catarina" next to "Bairro Alto", one of Lisbon's ...
Graça Apartment 2 Bedrooms and Terrace
This apartment boasts almost a perfect location: in the picturesque quarter of Graça, in Lisbon, right next to Baixa, Alfama and Chiado. This is t...
Hotel Bairro Alto
Lisbon finally has a top notch hotel in the cosmopolitan and trendy theatre district of Bairro Alto, from whence the hotel gets its name.
It r...
Palacete Chafariz del Rei
To define the Chafariz del Rey is not easy. It is not a boutique hotel, nor a bed and breakfast, but also not a pure luxury hotel. It is a bit o...
Pascoal Melo Apartment
Are you looking for a modern design apartment in the heart of Lisbon with everything you need to have a wonderful experience? Don't worry, we hav...
Pestana Palace Hotel & National Monument *****
Originally a 19th century palace, the Carlton has now been restored to its former architectural glory to become a superb five star hotel – certai...
Santiago de Alfama – Boutique Hotel
The Bica 2 Rooms Apartment
Tips from Travellers
Looking for the unusual and authentic? Take a look in our travel blog and find great things to do, great food with a selection of mouth-watering local specialities, our favourite destinations and much more.
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Congratulations! You leveled up, but you aren't logged in so we can't save your points.
The clip Erykah Badu Part 2 from Block Party (2005)
Categories movie-clips
Tags party, block, part, 2005, erykah, badu
Video Size: 420 x 315480 x 360640 x 480960 x 720
Flag This Item
Katy Perry - Part of Me - Cover by Missy Lynn
Vocals and Piano: Missy Lynn - http://www.missylynnmusic.com
Cello: Karlee-Kay Smith
Music Produced ...
81,251 |4
A bizarre and fantastic obstacle course for a biker.
50,399 |2
Ohio University Marching Band Performs Party Rock From LMFAO.
112,171 |5
337,493 |6
...part time fucking badass.
230,622 |4
Thumbs up to this guy for having the balls to actually do this.
2,162,439 |5
PSY, LMFAO, Dev, The Offspring, Bloodhound Gang all mashed up into one.
198,354 |4
Large party in Melbourne's south east with over $20,000 in damages. The parents have yet to find out.
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That was a one in a million shot!
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Let it sink in that you will never be as happy as these dogs are right now.
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VideoBash is your first and final stop for free funny videos, games and pictures guaranteed to brighten up your day. The funniest jokes and the most unbelievable pranks caught on tape have been collected in one spot for your viewing pleasure. This is entertainment at its best and no one does it better than VideoBash. These funny clips crackle with humor and they will definitely have you laughing till your sides hurt. Quality is our number one priority and the free funny vids here are the best of the best. There are no mediocre videos here. All the videos, jokes, pranks on VideoBash are the cream of the crop and you'll be hooked from the get go. The best part is you don't have to keep all this good stuff to yourself, you can share all the free entertainment videos with your friends.


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Bjorn the Swedish Australian Shepherd has devoted his adventurous life to discovering quality, gourmet coffee and specialty beverages. He and his friends love nothing more then a great cup of coffee before heading into the backcountry for some fresh tracks or a mountain run.
Monday 5:00 am – 6:00 pm
Tuesday 5:00 am – 6:00 pm
Wednesday 5:00 am – 6:00 pm
Thursday 5:00 am – 6:00 pm
Friday 5:00 am – 6:00 pm
Saturday 6:30 am – 5:30 pm
Sunday 7:00 am – 5:00 pm
We were so honored to be recognized in 2013 as the Best Coffee to Help Critters. We hope you'll vote for us this year and help us save even more animals this year!
Here's the City Weekly Survey link.
Your Best Bud may be featured as Pet of the week. If selected you are entitled to free drinks the week of the selection and your pet's photo and hobbies will be displayed along with the special drink for the week. Bjorn is friends with all animals including cats, birds, fish, rabbits, and ferrets just to name a few; so Bjorn's Bud does not necessarily have to be a dog. Submit your pet


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websites using the $ symbol on their website - meaning it may accept payment in this currency used in Israel.
A simple library that provides standard Unicode emoji support across all platforms.
Cascading grid layout library
jQuery: The Write Less, Do More, JavaScript Library.
A family of standard web feed formats used to publish frequently updated information like blog entries, news headlines, audio and video.
A pingback is one of four types of linkback methods for Web authors to request notification when somebody links to one of their documents. This enables authors to keep track of who is linking to, or referring to their articles.
This site uses the viewport meta tag which means the content may be optimized for mobile content.
Website using Instagram integrations or links.
Website with links to Instagram profiles or pictures
A semantic personal publishing platform with a focus on aesthetics, web standards, and usability.
nginx [engine x] is a HTTP server and mail proxy server written by Igor Sysoev.
The DOCTYPE is a required preamble for HTML5 websites.
The website contains Adobe Flash content embeded without the use of JavaScript.
UTF-8 (8-bit UCS/Unicode Transformation Format) is a variable-length character encoding for Unicode. It is the preferred encoding for web pages.
Wesites using favicon rel tag
A canonical link element is an HTML element that helps webmasters prevent duplicate content issues by specifying the "canonical", or "preferred".
Google's hosted library for web fonts. Allows websites to choose and use fonts from a free, wide variety of fonts.


text:
What is the analog for .Net
InvalidOperationException in
I'd probably go between one of two options:
A custom exception, best defined as follows:
class InvalidOperationException(Exception): pass
Just using
I don't believe there's a direct analogue; Python seems to have a very flat exception hierarchy.
There's no direct equivalent. Usually
ValueError or
TypeError suffices, perhaps a
RuntimeError or
NotImplementedError if neither of those fit well.
I'll partially agree with Chris R -- define your own:
class InvalidOperationException(Exception): pass
You get much benefit from defining your own exceptions this way, including building a hierarchy to fit your needs:
class MyExceptionBase(Exception): pass
class MyExceptionType1(MyExceptionBase): pass
class MyExceptionType2(MyExceptionBase): pass
# ...
# something
except MyExceptionBase, exObj:
# handle several types of MyExceptionBase here...
I don't agree with throwing a naked "Exception", though.
Similar Questions


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Ella Moss
Stretch Lace Top
Product not available
Have questions?
Chat with us or call 1.888.282.6060.
HideDetails & Care
Delicate lace shapes a sheer, decidedly feminine top with a rounded neckline that scoops low in back.
- Approx. length from shoulder: 24 1/2".
- Base layer shown sold separately.
- Nylon/polyester/spandex; dry clean.
- By Ella Moss; made in the USA.
- t.b.d.