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Darrelle Revis gets a chance to connect with ex-Patriots CB Mike Haynes
|12.18.14 at 4:57 pm ET
FOXBORO — When he was in San Diego recently, Patriots cornerback Darrelle Revis had the chance to catch up with former New England cornerback Mike Haynes.
Haynes, who was drafted by the Patriots in 1976, played his first seven seasons with New England before finishing his career with seven years with the Raiders. Revis said "it was great" getting the chance to connect with a Pro Football Hall of Famer.
"Just picking his brain and asking him how he covered wide receivers, his techniques," Revis said after practice on Thursday. "And some of them were similar in the things he was talking about and sharing. And some were different. I definitely took some of his tips and will hopefully try to use them in my game."
Revis said Haynes — who currently lives in Southern California — was invited to spend some time with the Patriots by coach Bill Belichick.
"When I saw him at first, I was kind of like, 'I know I know that face.' It looked familiar," Revis recalled. "Then Bill brought him around the team and introduced him and said, 'Hey, this is Mike Haynes.' I'm like, 'I knew it. I knew it was him.' I just waited around afterward. A bunch of guys did. Me, Brandon Browner, Devin McCourty and we actually got to talk to him.
"It's just my position and being a fan of those guys," he added. "They're very successful at what they do, so why not ask questions, so see what answers you can get from those guys."
Julian Edelman (thigh/concussion) remains among 12 Patriots limited
|12.18.14 at 4:50 pm ET
There were no changes to the Patriots' injury report from Wednesday, as every player was present at Thursday's practice in preparation for Sunday's game against the Jets at MetLife Stadium.
12 players were limited though, including Julian Edelman (thigh/concussion). With Edelman staying the same as he did on Wednesday, it is a good sign for his availability on Sunday. A concussion popped up next to his name on the report on Wednesday. It is still unknown when he suffered the concussion. LeGarrette Blount (shoulder), Kyle Arrington (hamstring) and Danny Aiken (finger) are among the 12 players limited.
One small note is that Dan Connolly's ankle injury has been changed to a knee injury. He was limited.
Quarterback Tom Brady (ankle) remained a full participant.
Here is a complete practice report:
Limited participation
LS Danny Aiken (finger)
CB Kyle Arrington (hamstring)
RB LeGarrette Blount (shoulder)
OL Dan Connolly (knee)
WR Julian Edelman (thigh/concussion)
OL Cameron Fleming (ankle)
LB Dont'a Hightower (shoulder)
DE Chandler Jones (hip)
WR Brandon LaFell (shoulder)
DE Rob Ninkovich (heel)
RB Shane Vereen (ankle)
LB Chris White (ankle)
Full participation
QB Tom Brady (ankle)
Report: Brad Allen will work as referee for Patriots-Jets
|12.18.14 at 3:20 pm ET
First-year referee Brad Allen will work as the referee for Sunday's Patriots-Jets game at MetLife, according to FootballZebras.com.
This will mark Allen's second New England game of the season — he was the official for the Oct. 23 game between the Patriots and Bears. Allen, who was one of three new hires this offseason, worked as a referee in the ACC for the past nine years, and has also worked as the head official for the 2012 Rose Bowl and the 2014 Sugar Bowl.
Here's a look at who has worked as the lead official for each New England game this year, and the corresponding penalties for each game, not counting the flags that were offset or declined.
Sept. 7 at Miami: Walt Anderson — 9 penalties, 100 yards (Dolphins — 4 penalties, 26 yards)
Sept. 14 at Minnesota: Tony Corrente — 15 penalties, 163 yards (Vikings — 7 penalties, 58 yards)
Sept. 21 vs. Oakland: Pete Morelli — 6 penalties, 59 yards (Raiders — 6 penalties, 49 yards)
Sept. 29 at Kansas City: John Parry — 3 penalties, 30 yards (Chiefs — 4 penalties, 35 yards)
Oct. 5 vs. Cincinnati: Jerome Boger — 12 penalties, 114 yards (Bengals — 4 penalties, 37 yards)
Oct. 12 at Buffalo: Walt Coleman — 9 penalties, 60 yards (Bills — 8 penalties, 107 yards)
Oct. 16 vs. Jets: Bill Leavy — 9 penalties, 64 yards (Jets — 7 penalties, 70 yards)
Oct. 23 vs. Chicago: Brad Allen — 7 penalties, 38 yards (Bears — 5 penalties, 41 yards)
Nov. 2 vs. Denver: Walt Anderson — 9 penalties, 71 yards (Broncos — 10 penalties, 72 yards)
Nov. 16 at Indy: Pete Morelli — 5 penalties, 53 yards (Colts — 4 penalties, 27 yards)
Nov. 23 vs. Detroit: Tony Corrente — 11 penalties, 89 yards (Lions — 9 penalties, 54 yards)
Nov. 30 at Green Bay: Ed Hochuli — 4 penalties, 25 yards (Packers — 4 penalties, 22 yards)
Dec. 7 at San Diego: Bill Leavy — 6 penalties, 70 yards (Chargers — 8 penalties, 61 yards)
Dec. 14 vs. Miami: Bill Vinovich — 5 penalties, 51 yards (Dolphins — 5 penalties, 35 yards)
Dec. 21 at Jets: Brad Allen
For more on Allen's work as a referee, check out his page at Pro Football Reference. For more information on this week's assignments, click through to the always reliable Football Zebras. And for more Patriots news, check out weei.com/patriots.
Rob Gronkowski, Darrelle Revis take turns talking each other up
|12.18.14 at 3:02 pm ET
FOXBORO — With the debate around Darrelle Revis and Rob Gronkowski as potential MVP candidates, this afternoon in the Patriots locker room, we decided to ask each player about the other one and what they bring to the field.
"He's a great player," Gronkowski said of Revis. "He's just so great with ball skills and he's just so relaxed out there. You don't even think he's trying — that's how good he is. When you see a player like that, you're like, 'Man, is he trying?' He's just right at the ball every time. That just means he's got a lot of skills and he's quick on his feet. The day he can react to a ball is unbelievable. He's a great corner. It's great to have him on our team."
"The same stuff you see in the game, he's doing at practice," Revis said of Gronkowski. "He's humble. He's humble about it — the way he approaches the game. He goes out and works. He works at it. Him and Tom [Brady], the chemistry they have, you see them working at it, week in and week out at practice. You just have to give them credit for what they do. They're working hard, and the catches you see in the game are the ones you see in practice. You're just in awe sometimes of how much chemistry they have between the two."
For more Patriots news, check out weei.com/patriots.
Julian Edelman (thigh/concussion) present at Patriots practice Thursday
|12.18.14 at 12:25 pm ET
All Patriots players were in attendance at the start of practice Thursday afternoon at Gillette Stadium, according to multiple reports. The team is preparing for Sunday's game against the Jets at MetLife Stadium.
This comes a day after Julian Edelman had a concussion added to his name on the injury report Wednesday. Given he played in the final minutes of Sunday's win and spoke postgame, there was a thought the injury occurred in Wednesday's practice. Having him present at the start of practice on Thursday is a good sign for his availability Sunday.
Practice squad offensive lineman Caylin Hauptmann returned to practice after not being present at the start of Wednesday's session.
For more Patriots news, check out weei.com/patriots.
Dolphins' Cortland Finnegan on Tom Brady playing into his 40s: 'Tell him to wake up from whatever dream he is in'
|12.18.14 at 7:48 am ET
It's no secret 37-year-old Tom Brady doesn't think his playing days are anywhere close to being over. He's been on record saying he wants to play into his 40s.
Dolphins cornerback Cortland Finnegan isn't so sure of the idea.
"He's asleep," Finnegan said to to the Palm Beach Post. "Tell him to wake up from whatever dream he is in.
"He can probably do it mentally, but physically, as the game evolves and gets faster and the guys at the defensive end position get bigger, it's going to be tough. I don't know that he'll be able to recover as fast."
The Patriots are coming off of a 41-13 win over the Dolphins Sunday, a game in which the Patriots clinched their sixth straight AFC East title. Brady went 21-for-35 with 287 yards, two touchdowns and an interception. The quarterback is also in the conversation for his third career MVP award.
Finnegan, 30, went on to admit Brady is a good player and is a sure Hall of Famer.
"You've got to give him his props," Finnegan admitted. "He's a Hall of Famer, one of the best, and I will give him the benefit of the doubt because he's done it with lesser players than other guys.
"He was born in a manger, I'll say that much. But I'm not sure at age 40 he wants to take a blind-side hit and get back up."
For more Patriots news, visit weei.com/patriots.
Rob Ninkovich's 'consistent' play has him mentioned with Hall of Famer Andre Tippett
|12.18.14 at 6:00 am ET
FOXBORO — There was a time where Patriots defensive end/outside linebacker Rob Ninkovich was considered underrated. Not so much these days, especially when he is now in the same sentence as former Patriots great Andre Tippett.
By recording a sack in last Sunday's win over the Dolphins, Ninkovich has recorded eight or more sacks in three consecutive seasons — the first Patriots player to do so since the Pro Football Hall of Famer Tippett achieved the feat from 1985-87.
"Every year I have high expectations of what I should do out there and set goals for myself," Ninkovich said Wednesday. "I've been able to just be consistent. The more consistent you are the better you are."
The versatile Ninkovich is able to lineup seemingly anywhere in the front-seven. He can line up as a defensive end, an outside linebacker, or even get down in a 3-point stance if need be. Ninkovich isn't the only player with such versatility on the defense, as Chandler Jones and newcomer Akeem Ayers are virtually the same way.
Ninkovich finally got to be on the field at the same time with both players on Sunday, as it was Jones' first game back since suffering a hip injury in Week 7. Having all three on the field presented some matchup problems for Miami, and paid off with Jones having 1.5 sacks, Ninkovich adding another, while Ayers had a tackle for a loss.
"The more guys that you can have doing different things defensively you're better off," said Ninkovich. "You can just be very multiple and what you can do and you have guys that can do a lot of different things and that helps your team out. The more you can do the better. I am happy to have all those guys out there with me making plays."
The nine-year veteran — six with the Patriots — has played in 84 straight regular-season games, the most in the NFL among defensive ends. He's also started in 63 straight, also the most in the NFL.
As much as he plays, he's done a tremendous job of not being flagged for penalties. He was not flagged once this year until he was flagged twice against the Colts, nine games into the year, and he hasn't been flagged since. The Patriots as a team have not been as good, as they have been flagged for 110 penalties (fifth-most in the league) for a total of 987 yards (third-most in the NFL).
"It's tough because obviously you want to play smart football," said Ninkovich. "Sometimes some of those calls it is hard to prevent some of them. But you have to do your best to play within the rules. That is what they are there for. Again, we're out there playing hard, flying around, trying to make football plays. You can't really slow yourself down, you just have to go play."
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Houston star James Harden played down talk of being this season's NBA MVP after his latest high-scoring triple-double on Tuesday as the Cleveland Cavaliers stumbled to defeat against Utah.
Russell Westbrook fell one rebound shy of his 18th triple-double of the season, but his 21 points were plenty in the Oklahoma City Thunder's 109-94 NBA victory over the Bulls in Chicago.
James Harden had 40 points, 11 assists and 10 rebounds for his 10th triple-double of the season to help the Houston Rockets beat the Toronto Raptors 129-122 on Sunday night for their eighth straight NBA victory.
Russell Westbrook had 32 points, 17 rebounds and 11 assists for his 17th triple-double of the season as the Oklahoma City Thunder beat the Denver Nuggets 121-106 in the NBA on Saturday night.
LeBron James scored 36 points, carrying Cleveland while Kyrie Irving and Kevin Love had slow starts in their return to the lineup, and the Cavaliers beat the Brooklyn Nets 116-108 on Friday night.
Dennis Schroder scored 23 points and Atlanta beat New Orleans 99-94 to win its fifth straight, even as shooting guard Kyle Korver spent the entire game on the bench amid reports he could soon be traded to Cleveland.
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Jimmy Butler scored 52 points and outdueled Kemba Walker, carrying the Chicago Bulls to a 118-111 victory over the Charlotte Hornets on Monday night.
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Lincoln Square, Chicago
|This article needs additional citations for verification. (June 2012) (Learn how and when to remove this template message)
|Lincoln Square
|Community area
|Community Area 04 - Lincoln Square
Location within the city of Chicago
|Coordinates: 41°58.2′N 87°41.4′W / 41.9700°N 87.6900°WCoordinates: 41°58.2′N 87°41.4′W / 41.9700°N 87.6900°W
|United States
40th Ward47th Ward
|• Total
|2.57 sq mi (6.66 km2)
|Population (2010)
|• Total
|• Density
|15,000/sq mi (5,900/km2)
|Demographics 2010 [1]
|• White
|• Black
|• Hispanic
|• Asian
|• Other
|Time zone
|• Summer (DST)
|ZIP Codes
|parts of 60625, 60640
|Median household income[2]
|Source: U.S. Census, Record Information Services
Lincoln Square, located on the North Side of the city of Chicago, Illinois, is one of 77 well-defined Chicago community areas. Greater Lincoln Square encompasses the smaller neighborhoods of Ravenswood Gardens, Ravenswood, Bowmanville, Budlong Woods and Lincoln Square (neighborhood). Although it is sometimes known by these other names the City of Chicago officially designated it as Lincoln Square in 1925.
In the 1840s, farming was begun in this area by newly arrived German Americans. Two brothers, Lyman and Joseph Budlong arrived in 1857 to start a commercial pickling operation near what is today Lincoln Avenue and Berwyn. They later opened a commercial green house and flower fields to provide flowers for the then new Rosehill Cemetery. In 1925, to honor Abraham Lincoln, the Chicago City Council named the area Lincoln Square, and a prominent statue of the namesake was erected in 1956.[3]
About 44,000 people live in the neighborhood along with over 1,000 small and medium-sized businesses. It is accessible through the Brown Line of the 'L'. The neighborhood is bounded by Bryn Mawr and Peterson Avenues on the north, Montrose Avenue on the south, Ravenswood Avenue on the east and the Chicago River on the west. Its housing stock consists of private residences and small apartment buildings.
The commercial heart of Lincoln Square is located at the intersection of Lawrence, Western and Lincoln Avenues. Lincoln Avenue southeast of this intersection is home to a wide variety of restaurants and shops. Lincoln Square is historically known as a heavily German influenced and populated neighborhood,[4] but now one is just as likely to see shops catering to Thai or Middle Eastern cultures. Still, the neighborhood is home to a number of German businesses, notably the Chicago Brauhaus, Merz Apothecary and Lutz Café & Bakery, and is the home of the Chicago branches of DANK (the German American National Congress) and the Niedersachsen Club. The German-language weekly newspaper Amerika Woche was born in Lincoln Square in 1972, though its original headquarters above the Brauhaus is now only a bureau.
Events such as festivals and live musical performances are frequently held in Lincoln Square. The Apple Fest is a longstanding tradition in Lincoln Square that brings the community together to celebrate the beginning of fall. Dozens of vendors participate in the event each year selling autumn-themed crafts and apple-themed treats, such as fresh baked apple pies, bushels of apples, hot apple cider and apple pizza.[5] The Square Roots Festival, which is held every summer, celebrates Lincoln Square's history in music and German culture with live performances from local musicians and craft beer from local breweries.[6]
- Bowmanville
- Budlong Woods
- Lincoln Square
- Lincoln Square North
- Ravenswood
- Ravenswood Gardens
Points of Interest[edit]
- Conrad Sulzer Regional Library
- Cambodian Association of Illinois
- DANK Haus German American Cultural Center
- Old Town School of Folk Music
- Rosehill Cemetery
- Kindred Hospital Chicago North
- Swedish Covenant Hospital
Chicago Public Schools operates public schools.[7]
K-8 schools include:[8]
- Budlong Elementary School
- Chappell Elementary School
- Jamieson Elementary School
- McPherson Elementary School
- Waters Elementary School
Amundsen High School is the designated CPS high school for most of the community area, while a small section is zoned to Mather High School.[9]
Other schools:
- Adler Schools
- Lycée Français de Chicago/The French International School[10]
- North Shore Junior Academy
- Queen of Angels Elementary School
- St. Hilary's Elementary School
Public Art[edit]
- Berlin Wall Monument (Western Avenue Brown Line Station), 2008
- Lincoln/Leland Mural (Lincoln Quality Meat Market), 2007
- Greater Rockwell Mural (Beans and Bagels), 2005
- Lincoln/Sunnyside Mural, 1997
- The Maypole (Leland and Lincoln), 1999
- Giddings Square Fountain, 1999
- Lombard Lamp (Giddings Square), 1979
- The Chicago Lincoln statue (Corner of Western, Lawrence and Lincoln), 1956
- The Lincoln Square Mural (Lincoln Square Athletic Club), 1991
- Amy's Candy Bar
- Blackbird Gallery and Framing
- The Book Cellar
- Budacki's Drive In
- Caravan Guitars
- The Chicago Mosaic School
- The Chopping Block
- Davis Theater
- Café Selmarie
- Degerberg Academy of Martial Arts
- Enjoy, An Urban General Store
- Heather Parker Photography
- Lincoln Square Athletic Club
- Merz Apothecary
- Savory Spice Shop
- Timeless Toys
The following events occur within the neighborhood on an annual basis.
- Ravenswood Run 5K
- May Fest
- Lincoln Square Summer Concert Series
- Square Roots
- Lincoln Square Poetry Fest
- German-American Fest
- Lincoln Square Fall Apple Fest
- Friends of the Craft Beer Festival[11]
- Friends of the Grape Wine Festival
- Christmas Tree Lighting in the Square
- Rib Fest
Bordering Community Areas[edit]
- ^ Paral, Rob. "Chicago Demographic Data". Retrieved 3 June 2012.
- ^ Paral, Rob. "Chicago Census Data". Retrieved 22 September 2012.
- ^ Zangs, Mary (2014). The Chicago 77. Charleston, SC: History Press. p. 26. ISBN 9781626196124.
- ^ McKeough, Kevin. "A Guide to Lincoln Square". Chicago Magazine. Retrieved 16 July 2013.
- ^ http://www.lincolnsquare.org/apple-fest
- ^ http://squareroots.org/about/
- ^ "Lincoln Square" (map). City of Chicago. Retrieved on December 24, 2016.
- ^ "Elem North" (). Chicago Public Schools. 2013. Retrieved on September 30, 2016.
- ^ "HS North/Near North." Chicago Public Schools. 2013. Retrieved on September 30, 2016.
- ^ French International School, Chicago, web site]. Retrieved October 7, 2016.
- ^ http://www.lincolnsquare.org/events/details/friends-of-the-craft-14182
External links[edit]
|Wikivoyage has a travel guide for Chicago/Lincoln Square.
- Official City of Chicago Lincoln Square Community Map
- DANK-HAUS German Cultural Center Lincoln Square
- Lincoln Square Chamber of Commerce
- Lakeside Community Development Corporation
- Ravenswood Industrial Council
- Greater Rockwell Organization
- Greening of Ravenswood
|North Park, Chicago
|West Ridge, Chicago
|Edgewater, Chicago
|Albany Park, Chicago
|Uptown, Chicago
|Irving Park, Chicago
|North Center, Chicago
|Lakeview, Chicago


text:
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text:
Financial Accountant
1 day left
- Recruiter
- Finance and Accounting
- Location
- Central London / West End
- Salary
- £45000 - £50000 per annum
- Posted
- 02 Feb 2017
- Closes
- 02 Mar 2017
- Sector
- Accountancy
- Contract Type
- Permanent
- Hours
- Full Time
MY client is a fantastic listed menswear brand located in Central London. They have undergone a period of transformation to drive the business's new growth strategy and the finance team is growing. They offer a variable, fun, relaxed work environment with constant opportunities to learn & grow.
Reporting to the Financial Controller, you will have a core role in the day to day business from a financial perspective and will liaise with all lines of business.
This role is designed as a development opportunity for a newly-qualified ACA accountant and will see you work within the group team. This team is made up of high calibre ACA trained individuals who will aid your transition from practice into industry and your longer-term learning. This role is essential in the development of a clear accounting structure which will enable the FP&A team to grow and provide further opportunities.
Your key responsibilities in this Group Accountant position will be:
- Liaise with business units/division to ensure reporting to Group is both timely and to a high standard
- Group reporting will require you to prepare an element of the monthly consolidated accounts (consolidating, reconciliations, journals etc)
- Leading on elements of month end reporting as well as external reporting at group level providing reports to senior financial stakeholders
- Deliver accounting updates and training to segment finance teams and help in performing assessments of any upcoming revisions to accounting standards;
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- Project work including, but not limited to, redesign of the chart of accounts; assistance with corporate re-simplification; systems improvements
An Ideal Candidate For This Group Accountant Position You Will Be
- An ACA qualified accountant (Big 4 training preferable)
- Possess a strong academic background (educated to degree level; 2.i and above)
- Show strong technical accounting experience: IFRS; consolidations
- Demonstrate clear attention to detail and the ability to be thorough in your work whilst meeting strict deadlines
- Have a flexible approach to working in a fluid environment
- Eligible to work full-time in the UK
The offer to the successful candidate will be between £50,000-£55,000 + flexible benefits, pension (9%), and travel discounts.
You will also receive a dedicated training and development programme to further your career within the business and aid the transition into industry.
Robert Half Ltd acts as an employment business for temporary positions and an employment agency for permanent positions. Robert Half is committed to equal opportunity and diversity. Suitable candidates with equivalent qualifications and more or less experience can apply.


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text:
I tought id make this thread for those interested in using NMDA antagonists for drug tolerance.
NMDAR and opioid tolerance:
(PMID: 19806811) Development of morphine induced tolerance and withdrawal symptoms is attenuated by lamotrigine and magnesium sulfate in mice
From these results it is concluded that lamotrigine and magnesium sulfate alone or in combination could prevent the development of morphine tolerance and withdrawal symptoms. Glutamate release inhibitory effect of lamotrigine and its possible mechanism and property of magnesium, blocking the N-Methyl-D-Aspartate (NMDA) receptor calcium channel, is probably its mechanism on preventing morphine induced tolerance and dependence.
(PMID: 19764437) Anti-opioid action of glutamate-NMDA receptor systems underlying morphine analgesic tolerance
The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanisms underlying opioid tolerance and dependence are not always explained by cellular adaptation mechanisms alone. This review focuses on the plasticity in neuronal circuits achieved through an enhancement of so-called anti-opioid glutamate/NMDA receptor synaptic activities.
(PMID: 18819620) Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice.
From these results it may concluded that Dextromethorphan and midazolam alone or in combination could prevent the development of morphine induced tolerance and dependence. These effects can be related to the N-Methyl-D-Aspartate (NMDA) receptor antagonist behavior of Dextromethorphan and GABA-receptor agonist property of midazolam.
(PMID: 18177675) The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism
Using the C-fibre reflex as a nociceptive response elicited by a wide range of stimulus intensities in the rat, we recently reported that a single treatment with (+)-HA966, a glycine site-specific NMDA receptor antagonist: (1) potentiates morphine antinociception; and (2) reverses an established morphine tolerance.
(PMID: 17994223) NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats
CONCLUSIONS: The results, together with previous research, suggest that NMDA receptors are broadly involved in opiate-induced plasticity, including the development of opiate tolerance and sensitization.
NMDAR and ethanol tolerance:
(PMID: 1596749) Effect of (+)MK-801 and ketamine on rapid tolerance to ethanol
The findings suggest that NMDA antagonists block rapid tolerance by preventing some adaptation that occurs during intoxicated practice.
(PMID: 1831064) NMDA antagonist inhibits rapid tolerance to ethanol
These data suggest that the known role of NMDA receptors in long-term synaptic facilitation may underlie the effect of learning in the development of tolerance to the motor-impairing and hypothermic effects of ethanol.
(PMID: 16790637) Ethanol-induced hypnotic tolerance is absent in N-methyl-D-aspartate receptor epsilon 1 subunit knockout mice
Our results indicate epsilon1 subunit containing the NMDA receptor might be involved in the development of ethanol-induced hypnotic tolerance.
(PMID: 15153783) Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons
These data suggested that ethanol inhibition and subsequent tolerance development is associated with changed sensitivity to NMDA in the RVLM, which may play important roles in the ethanol regulation of cardiovascular function.
(PMID: 8724445) Dizocilpine prevents the development of tolerance to ethanol-induced error on a circular maze test.
Chronically, dizocilpine (0.075 and 0.15 mg/kg) prevented the development of tolerance to the effect of EtOH on error score, even though the lower dose of dizocilpine permitted tolerance to the effects of EtOH on running. These results suggest that NMDA receptor antagonists selectively inhibit tolerance to cognitive effects of ethanol even when the antagonists do not affect motor performance.
(PMID: 8545482) D-cycloserine enhances rapid tolerance to ethanol motor incoordination
The enhancement of ethanol tolerance by D-cycloserine and the antagonism of this effect by ketamine cannot be attributed to changes in pharmacokinetics of ethanol. Taken together, these results confirm the participation of the NMDA receptor system in the development of tolerance to ethanol, and reinforce earlier findings about the involvement of learning in tolerance.
(PMID: 7938132) Effect of NMDA antagonists on rapid and chronic tolerance to ethanol: importance of intoxicated practice
Therefore, daily administration of the NMDA antagonists was necessary to block development of chronic tolerance. Daily injection of (+)MK-801 (0.25 mg/kg IP) failed to block chronic tolerance, but inclusion of a second dose of (+)MK-801 daily, and progressive increase of this second dose during the chronic treatment period did block chronic tolerance. Unlike (+)MK-801, ketamine does not have motor-impairing effects of its own, and does not potentiate those of ethanol; it was, therefore, used in the remaining experiments.
(PMID: 7953754) Interaction between N-methyl-D-aspartate (NMDA) and serotonin (5-HT) on ethanol tolerance
Earlier work from this laboratory had shown that 5-HT is involved in the development of tolerance to ethanol, and that enhancement of 5-HT levels by L-tryptophan accelerated tolerance development. To explore the possibility that NMDA receptors are involved in the 5-HT effect on tolerance, we examined the effect of a noncompetitive N-methyl-D-aspartate (NMDA) antagonist [(+)MK-801] on the ability of L-tryptophan to enhance tolerance to the effect of ethanol on tilt-plane test performance by the rat. L-Tryptophan treatment resulted in the development of rapid tolerance to a dose of ethanol that failed to produce such tolerance by itself. However, prior administration of (+)MK-801 blocked the L-tryptophan effect on rapid tolerance development, in a dose-dependent manner. These results suggest that NMDA receptors are involved in the 5-HT enhancement of ethanol tolerance.
(PMID: 8415841) Effect of D-cycloserine on rapid tolerance to ethanol
These findings are further evidence that the NMDA system, which requires activation by the glycine receptor, plays a major role in the development of at least some forms of ethanol tolerance.
(PMID: 8453972) Blockade of chronic tolerance to ethanol by the NMDA antagonist, (+)-MK-801
Tolerance to the effects of (+)-MK-801 itself did not occur over 2 weeks of treatment. These results suggest that NMDA receptors are involved in development of chronic tolerance to ethanol as shown previously with rapid tolerance.
(PMID: 8428601) Effect of NMDA receptor antagonists on rapid tolerance to ethanol
Results showed that (+)-MK-801 and ketamine blocked the development of rapid tolerance to ethanol on both tests. Since these drugs did not modify blood or brain alcohol levels in any of the groups, the blockade of ethanol rapid tolerance cannot be attributed to changes in pharmacokinetics of ethanol. These data suggest that the role of NMDA receptors in ethanol tolerance may be similar to their role in memory and learning, involving a facilitation of transmission in certain synapses.
NMDAR and stimulant tolerance: (unfortionally i found references regarding sensitisation, it is established however that NMDA antagonists upregulate several dopamine receptors backed up by many members that used it succesfull for stim tolerance).
(PMID: 2671566) Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801
(PMID: 9560846) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
(PMID: 11915303) Alteration of neuronal activities following repeated administration of stimulants
NMDAR and nicotine tolerance:
(PMID: ) The NMDA antagonist dizocilpine (MK-801) attenuates tolerance to nicotine in rats
These results suggest that the NMDA receptor may be involved in adaptation to both unconditioned and conditioned behavioural responses to nicotine.
(PMID: 18452252) The role of NMDA receptor antagonists in nicotine tolerance, sensitization, and physical dependence: a preclinical review
The aim of the present review is to discuss preclinical findings concerning the role of N-methyl-D-aspartate (NMDA) receptor neurotransmission in mediating the behavioral effects of nicotine, tolerance, sensitization, dependence, and withdrawal. Based on preclinical findings, it is hypothesized that NMDA receptors mediate the common adaptive processes that are involved in the development, maintenance, and expression of nicotine addiction. Modulation of glutamatergic neurotransmission with NMDA receptor antagonists may prove to be useful in alleviating the symptoms of nicotine abstinence and facilitate tobacco-smoking cessation.
(PMID: B8032593) Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists
The results suggest the involvement of NMDA receptors in adaptations of the behavioural and neurochemical effects of nicotine that occur as a result of repeated administration of the drug.
NMDA antagonists and dopamine
(PMID: 1382178) Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat.
D2 binding studies carried out in MK-801 chronically treated (0.3 mg/kg/day per os, for 50 days) and control rats revealed an increased receptor density in treated animals without a significant change in receptor affinity.
(PMID: 7770607) Effects of the NMDA-antagonist, MK-801, on stress-induced alterations of dopamine dependent behavior.
(PMID: 10443547) Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists.
The same treatment with amantadine did increase [3H]raclopride binding to dopamine D2 receptors by 13.5%.
(PMID: 10214758) Decreased striatal dopamine-receptor binding in sporadic ALS: glutamate hyperactivity?
In drug-naïve, sporadic ALS patients we demonstrated decreased striatal D2-receptor binding in vivo that could be partially reversed by the glutamatergic transmission blocker riluzole.
(PMID: 12832726 Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.
We can conclude that repeated administration of AMA, given together with IMI, induces the up-regulation of dopamine D2 and D3 receptors in the rat brain.
(PMID: 10096038) Modulation of dopamine D2 receptor expression by an NMDA receptor antagonist in rat brain.
In the striatum, a significant increase in striatal dopamine D2 receptor mRNA levels was shown in animals treated with CPP.
(PMID: 14997010) Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice.
The findings suggest that D1, D4, and NMDA receptors might interact functionally and that developmental absence of D4 receptors might trigger compensatory mechanisms that enhance expression of D1 receptors in NAc and CPu, and NMDA receptors in NAc, CPu, and hippocampus. The findings also encourage cautious interpretation of results in knockout mice with targeted absence of specific genes, as complex adaptive changes not directly related to the missing gene might contribute to physiological and behavioral responses.
NMDA antagonists and serotonin
(PMID: 9187317) Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain.
It is concluded that single administration of MK-801 may alter the density of serotonergic 5-HT1A receptors and in consequence influence the function of the central nervous system associated with activation of 5-HT1A receptors.
Anecdotal reports
I've been using Delsym (dextromethorphan polistirex, DXM, a sustained-release preparation of DXM) to prevent amphetamine-tolerance as long as I've been taking them. So that would be about 8-9 months of use without breaks, and the proof is in the pudding. :-)
I haven't developed any tolerance whatsoever to any of the drug's effects. The dose started at 30mg/day (of the XR formulation), but an extra 30mg capsule later in the day was added onto that after a few weeks because they seemed to wear off too quickly for me. I stayed on that until a couple months ago when I switched to the immediate-release formulation, which I find lasts about eight hours per dose (quite surprisingly!), with a come-up beginning at approximately T+0:15 hours post-dose, a pronounced effect at T+1:00 pursuant, the peak at T+2:00 through T+7:00, followed by a gentle comedown which ends about T+9:00. The only difference I find between the IR and XR formulations of the drug is actually that the IR form lacks the mid-dose sluggishness and consequent "second-wind". So one dose at 6AM *really* kicks in at 8AM, beginning to wear off at 1PM; taking the second dose at noon times everything just perfectly. If I'm planning on making rounds of the bars with friends at night or practicing/playing a gig with my band, I just pop an extra 30mg in the early evening as needed.
But back to the Delsym -- I used to take a full teaspoon of the 12-hour suspension twice daily (that's equivalent to 15mg Robitussin Maximum Strength Cough every six hours). This dose completely prevented any development of tolerance and *may* have even allayed some of the nastier stim side effects by antagonizing some excitatory neurotransmission via glutamate et al. For six weeks now though I've been taking Prozac at 40mg daily, which (along with its ultra-long-half-life metabolite, norfluoxetine) is among the most potent inhibitors of cytochrome P450 IID6 (aka debrisoquine 4-hydroxylase), along with quinidine and paroxetine. CYPIID6 is responsible for the metabolism via O-demethylation (removal of the methyl group at the sixth position in the structure) of dextromethorphan, which primarily acts upon PCP2 and sigma receptors, to the potent NMDA antagonist dextrorphan (DXO; the dextroratory form of the opioid levorphan, which is about equipotent to morphine). Thus I now take twice as much Delsym to ensure a more normal ratio of DXM to DXO in the blood. My doctor and all reseach I've done has assured me that this is perfectly safe (i.e. not nearly a dose sufficient to cause Olney's lesions, etc.). I would use another NMDA antagonist like Emenda (memantine HCl) if it were available to me, even if simply to avoid the simple carbohydrates in the syrup, but Medicaid will only cover three prescriptions monthly now that I've turned 21. I may, on the other hand, finally put my lab scale to good use and order pure dextrorphan tartrate from Sigma-Aldrich (0.5 grams = $63.30) so as to avoid the unnecessary PCP2/sigma activation associated with DXM. Another chemical I'm interested in is Merck, Sharpe and Dome Inc.'s (+)-MK-801 hydrogen maleate (dizocilpine hydrogen maleate), for which the Sigma-Aldrich "Cell Signalling and Neuroscience" catalog provides the following synopsis: "Highly potent and selective non-competitive NMDA receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol." The cost is prohibitive, though -- $43.10/5mg.i just wanted to follow up on the subject of DXM and amphetamines. it's been my XP that a recommended dose of cough syrup, the only active ingredient being DXM, taken with 90mg XR adderall are as follows:
-much smoother onset, more of a ramp than a rocket
-more mentally stimulating and less physically stimulating
-greatly reduced negative side effects(rapid pulse, rebound effect after dosage wears off) and condition of user less obvious to the outside world
-x-ray vision
i wish.
anyway, overall i am very pleased with the results of the combination. i plan on adding calcium and magnesium to my regimine as well.steady adderall xr use 30mg daily for months
accidentally got scripted IR not XR and then had it fixed for XR but had an extra bottle of IR now
Started using IR alternating with XR at times
eventually started to crush XR and parachute on days I wanted them to come on stronger.
Around this time dose started to increase to an extra 15 mg since i had the extra bottle...
Then came getting invited to my friends djing at a club and other clubbing events
I don't drink, smoke weed, or do any other drugs anymore, only other drug I use is clonazepam, and I WILL NOT abuse that, I've seen where benzo abuse takes you, and not going back there...that is merely something for longstanding insomnia and social anxiety (pre-existing to ADD diagnosis)
Started popping 60 mg IR
Started doing 60 on and off on regular days...but not all at once like on the club nights
eventually every other weekend or every weekend id do 90mg in one sitting
started to lose its effect...so I started blowing 60....
I got an extra 10mg IR added to my 30mg xr script
as finals approached, just to get basically baseline i needed 60mg, and to get focused or motivated it took 90. Ended up doing about 240 mg over two days (spread out doses)
but I never quite as focused as I used to be. never felt high at all.
Once finals were over, I saw where this was going, decided to say **** this **** I'm not wasting my script, my mental energy, and being depending on unreasonable amounts of amphetamine just to function, not even get the therapeutic effect.
abstained from usage for 5 days completely, took tyrosine, choline, nootropics, brain supplements, etc.
Today I decided, just to see how it goes, to take 30mg, less than my full prescribed dose, along with a tablespoon of delsym and some magnesium.
Not only did I get the euphoria and motivation, but I also got the focus and energy and I DIDN'T FOR ONCE end up with freezing cold fingers!!! and its lasted much longer than using 4 times as much has and im not crashing.
Personally, I think that along with vitamins and supplements to restore neurotransmitters, taking a few day breaks between using as well as using dxm and magnesium with your dosage can change the outcome of your entire experience.
one thing i've considered...while using adderall daily, i also used nootropics....
they counteract the nmda effects magnesium and dxm have i think..atleast the racetams.
i didnt use any today..
could aniracetam/other racetams possibly increase tolerance while using them?Small doses of Ketamine taken before a dose of dexedrine definitely did wonders to keep tolerance at bay...
But now that I'm slightly the wiser, I simply take the small doses of Ketamine, and skip the amp altogether .i take 30-45mg about 45 minutes to an hour before ingesting an opiate. and yes it works. i have been abusing opiates for about 2-3 months or so now and my tolerance has stayed at a pretty intermediate level. with dxm+weed 35mg of hydrocodone has me nodding pretty nicely.I started using DXM in conjunction with opiate use about 6-7 months ago. I always use at least 45mg, but usually 60mg of DXM with every dose of opiate. It did not reverse tolerance, but it prevented tolerance from increasing. Before I started the DXM I to slowly increase dosage every month, but once I started the DXM, and even now, my dosage has remained identical and with even slightly stronger effect from the opiate dosage than 6 months ago(so I guess some reversal may have occured).
Note: I also use a dose of 600mg of Tagament and 100mg of Diphendydramine with each opiate dose along with the DXM.It's an NMDA antagonist so it reduced and prevents tolerance to opiates, and for some reason it increases the warmness, analgesia, and euphoria, for me atleast. That is at therapeutic doses. Anything above 90mg's will ruin an opiate high.And more....actualy you guys ;like it or not, but i am right. ever try getting dexed up and then doing a line of coke? youll get so ****ing high its rediculous.
dxm prevents tolerance from building to ALL the drugs i listed, thats fact. but it also makes them feel stronger. opiates i notice a HUGE difference, coke i notice the BIGGEST difference, and then speed and nicotine i guess. look into it if you dont believe me im not bull****ting you
I'd have to agree with Klowns on this one. If only from personal anecdote. Yesterday, I started taking Robitussin for an awful cough with the flu but also had to complete a lot of work. Mind you I haven't felt particularly pleasant when taking Adderal in quite some time. Anyway I had taken about 50mg's of DXM an hour prior to taking the Adderal. Then took 40 mg IR. I should also note this is about double the dose I normally take. But god damn was I flying around it felt like some of the first few times ever taking it. Also, the last dose I took was around 10 pm last night and I have yet to fall asleep or even have any sign of sleepiness. This is strange because I can often fall asleep even after taking it late at night.dear good people
I SUCCESFULLY use dxm every day in small doses to prevent tolerance from building to my pain pills, and occasional pods/seeds. now let me see
i have been on opiates around ten years, but 4-5 years of CONSISTENT every day use of hydrocodone, and dxm. now, not ONCE in these years have i EVER asked my doctor to up my dose, (rather surprising to him i believe) and i still get EXCELLETN analgesia from just 1 7.5/325 hydrocodone a dose. sure i take mroe to get high every once in a while. but i dont actualy need more. and when i go on a binge and take a bunch, and run out on thursday, i cant get my pills till monday..............well when monday rolls around, i take ONE pill, smoke weed 15 minutes later and i am still STRAIGHT ****ED UP NODDING no joke. and no i am not a lightweight, i just dont like to run out of meds and be in withdrawal. idealy, 150-300 mg would be my choice of dose for the whole day, but alas, i cant get anyone to ****ign script me that much.
i take anywhere from 30-120 mg dxm in the morning. i find polystyrex works better than bromide, it lasts all day, and it wont cause a sharp spike in psychoactive effects. (i wouldnt feel them anyways i use to drink 4 bottles of tussin a day for about 6 years and i had to go to serious rehab for that addiction). i havent fried out on it in almost exactly oen year. this drug IS a miracale drug, and no i wouldnt call it toxic to the brain. i would say it HELPS THE BRAIN, i mean, it is basicaly useful in EVERY sort of addiction, not just opiates, it can prevent tolerance to ALL kinds of drugs like caffeine nicotine amps, i mean ALL MANNER of drugs.
all the people i know who heavily abused dissociatives are now off them and are some of the most intelligent people i know.
olneys is OUT THE ****ING WINDOW come one now people. if wedMD calls DXM a "Co-Analgesic", well **** thats good enough for me. it also greatly reduces fybromyalgia pain even by itself, and if i take grapefruit juice first then a small dose of dex when i have NO pain meds, it actualy gives me SIGNIFICANT wd relief AND pain relief.
look more into these drugs before you bash them anyone, please, because i believe them to be miracle drugs.
and ketamine, is the safest of the dissociateves anyways, just for your information. even when all that olneys **** was going around, they said PCP was most likely to cause it, followed by dxm, followeed by ketamine. i have also have ++++ psy experiences on K.
show me any real evidence that the **** is hard on the brain any ill listen. but even if it is miniscualy bad for you............its either that, or a never ending skyrocketing opiate tolerance.............hummmm.....hard descision
peaceI'm also inferring from the study that the researchers must consider DXM safe taken long-term. I mean, assuming 80mg morphine qid, we're talking 320mg of DXM daily -- still quite a bit shy of the gram recommended above, but 320mg is (for most people) a very psychoactive dose. I'm only taking 15mg and definitely feel it helps. I can't explain my lack of Ultram tolerance after 400mg/day for several months any other way.Well, I'm hanging on 40mg of Adderall with 3 NDMA antagonists: L-Theanine at 100-200mgs, DXM 60mg. Magnesium up to 1000mg. I first used 10 mg Adderall but without NDMA antagonists in two months had to jump up to 40 mgs. Then I started using the above and I can say that (I think) they work. I'd use acamprosate or memantine if i'd have access though.Hiya,
I wasn't able to look through all these studies to see if they gave any definitive information on human dosages of DXM which block NMDA receptors, but 60mg Delsym seems to work great for me -- there's no way in hell I'd still be finding relief from 60mg Adderall if it weren't for the DXM!Vince,
Memantine, for me at least, is effective for amphetamine tolerance. Whereas before it would poop out ofter about 3 days, leaving me wrung out and irritable, it now gives me a smooth effect (one dosage of 40mg. lasts about 12hours), that I can take every day- giving me energy, concentration, motivation and social confidence.
I've waited to log this post because I was hoping to learn exactly what mechanisms allowed memantine to work this way. But, at this point, at least, I will have to say that it is a bit of a mystery. Presumable, amphetamine induces hyperglutaminergic activity, which incuces the tolerance, which the memantne is able to prevent by limiting glutaminergic activity to within physiologically safe bounds.
Also memantine is seemingly effective for tardive dyskinsia (see patent referred to above). Also effective as a adjunct mood stabilizer to valporate acid (sp?) and possibly lamotrigine.
It is speculated to be effective for OCD disorders. Also I can't help but wonder if it won't prevent , at least in some , instances, of AD poop out.
BTW: I take, 5mg/day selegiline, 40mg/day adderall, 30mg./day memantine, 4g.day klonopin at night and 50mg./day of amisulpride.
AndrewBIt's hardly utopia, but memantine to attenuate amphetamine tolerance to mood/motivational effects has worked for me (at 9 weeks in), and among a few others, this guy who documented his experiences with some extensiveness:
Like andrew I in the past acquired complete tolerance to the mood/motivational effects of amphetamine after about 2 or 3 days of chronic dosing, leaving a concentrative effect which for me (not everyone) always felt zombifying. These mood/motivational effects (in combination with the concentrative effect) are considerably more therapeutic for me.> I'm not concerned with development of tolerance as I've been able to maintain a constant effect from amphetamines for months now without raising dose. In all fairness, I do take 60mg Delsym (dextromethorphan polystirex) twice daily, which is quite likely preventing tolerance. My pdoc endorses the use of DXM to all his stimulant-treated patients now, ever since I brought it to his attention months ago. He's seeing many patients finally stabilized on doses of amphetamines whereas they used to escalate monthly or even weekly. It doesn't seem to be working as well for his patients taking methylphenidate.I take (d)-amphetamine 15mg IR ~3 days per week. It works very well for SA and sometimes can make me very extroverted, but it's not a practical treatment as tolerance sets in if I use it more frequently.
After hearing many glowing reports about how memantine inhibits the development of amphetamine tolerance, I started taking it at 5mg for 4 days, and have been on 10mg/day since. On the 12th day of being on 10mg memantine, I took my usual 15mg dose of amph, and felt a powerful surge of euphoria, sociability, confidence, and was completely free of SA. It was just like taking amphetamine for the first time! Over the next 4 days, I took 15mg each morning but skipped one day. Each dose was just as powerful and efficacious, AND the duration was extended to ~7-8 hours! So this brings me to today, where I decided to reduce my amph dose to 10mg, and it's working even better than 15mg did before starting memantine.
Could memantine render amphetamine a practical longterm treatment for SA/social anhedonia (among many other disorders)? Looks like it may, but I'll have to give it the test of time. Anyone else have any experience with this regimen?Memantine has truly saved my life, i do not exaggerate. Although Memantine, by itself, doesn't offer me significant benefits (other than reduction of OCD) it pretty much, is the most important part of my regimen. It doesnt seem possible to actually prevent the tolerance to the Actual beneficial effects of Amphetamine, but....it is possible. I see no benefit in taking Amphetamine at all, if not combined with Memantine. I currently take 15 mg Memantine a day......5 and 10mg/day both significantly inhibited tolerance, however, only for a period of 2-4 weeks, I could take Amphetamine consistently (every day, 30mg) with its mood-elevating and anxiety-reducing and pro-social benefits, continuing to remain and be of use. When tolerance becomes a problem, i take short 2-5 day breaks from Amphetamine, and every time, my tolerance goes down significantly, and I am able to resume amphetamine, with its beneficial effects being much stronger again.
There is ALOT of evidence, that Memantine and other NMDA antagonists/glutamate antagonists reduce some of the neurotoxicity of Amphetamine. Some of the neurotoxicity will remain, regardless of NMDA antagonism.....however, glutamate itself, is responsible for a significant portion of amphetamine-induced neurotoxicity......honestly, Memantine appears to be, almost perfect, without any obvious shortcomings. It will only be a matter of time, before a negative effect of such, is discovered, but nevertheless, Its positive effects, appear to greatly outweigh its cost. Yay for memantineMemantine is good stuff. I've been taking 5mg a day for several weeks now, and i'm just now starting to see its tolerance prevention ability. I took one 20mg adderall XR + 5mg memantine this morning after a 4 day break from adderall and it has worked great all day. I lost the magic there for awhile but today the addy is working like it did during the first few months and this is just from 20mg.
Results 1 to 25 of 544
05-05-2010 20:06
Last edited by MeDieViL; 21-11-2010 at 21:19.
09-05-2010 14:23
Good work collating everything brother, interesting reading there.
09-05-2010 15:48
Couple more anecdotal bits from myself:
Originally Posted by monstanoodle
09-05-2010 19:50
Interesting thx for posting your experience, altough i have to say that its possible that ketamine isnt as effective as the other nmda antagonists due to its short half life, when it wears off there could also be a small rebound wich would be counterproductive. But it did seem to help you.
Also a couple of extra notes:
- Memantine is probably the best agent for tolerance to therapeutic doses of amp/opiates etc, but maybe not to recreational doses of a combination of several agents, this is because it has a VERY low affinity for the NMDA receptors, this way it can even be considered a cognitive enhancing drug as it doesnt interfere with normal cognition in most cases. However this also means that it can be easily overpowered if taking too high doses or combo's of several drugs.
When going on a drug binge it would be better to use more powerfull NMDA antagonists like DXM (or augment memantine with some DXM).
- When using DXM go for the extended release version to make sure it doesnt wear off too soon.
16-05-2010 23:05
Basically I'm not one of those people who likes to snort half a G and fall into that strange ol' K-hole, I prefer to take small lines continuously.
So, eventually I will meet the K-hole, but I build up to it slowly - little line by little line by little line.
This will have kept the blood concentration more constant no doubt
The Memantine does sound really good and would likely be perfect for the job
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17-05-2010 09:32
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You missed the most obvious one of all - NMDA antagonists effect on the tolerance of NMDA antagonists - has to be the most ridiculous of any drug. Someone came round with a bit of ket last night - been a bit of a drought on so had none for many months - tolerance has barely dropped in all that time. On the plus side, maybe it's kept my tolerance to other stuff down to more managing levels too
09-06-2010 18:17
Post has been updated, if anyone has more ref's regarding the interaction between NMDA and other receptors, please post them.
31-10-2010 02:27
At the request of the OP, here's my purely ancedotal experience, the pharmacology is largely over my head. Having read that the use of DXM (among other which I do not have easy access to) could prevent tolerance to amphetamines I decided to give it a try. I had spent about a week with my anti-drug family, so I had used no drugs except a few benzos and a little pot. So my amphetamine tolerance was pretty low by my standards, though probably still off the charts compared to most people. I had easy access to but high quality ice and to anny meth [snip]. Obviously I can't give specific numbers for the purity of either, and I wasn't weighing my dose. I would just throw a large amount in a spoon and put an amount of water on it which was not sufficient to dissolve all the meth. I would then draw up a shot of what I assume to be the maximum amount of meth which will dissolve in that amount of water. If anyone knows how much meth say a CC of water will dissolve I'd be curious to know. Anyway, I would draw up 30 units per shot. This was a very strong dose, even with my tolerance. I was taking 60 mgs of DXM in the form of 4 15 mg robotussin cough gels twice a day, though I'm sure I missed a few doses given how spun I was. I would do a shot about every six hours, although I wasn't timing them or anything. This continued for what I later realized was 12 days. I neither upped my dose nor increased the number of doses per day. I've stay up this long on more occasions than I care to admit, and I would typically be up to around 50 units every 4 hours or so. Yes, I realize how insane these doses must seem. But even at the end (when my wife told me it was time to get some sleep) I had noticed no increase in tolerance. Also I had no paranoia at all, not even the level which would have been rational for someone in my position. I haven't had a chance to try this again, my lifestyle has changed to the point that more than a weeekend warrior type tweeking isn't an option. But I know myself well enough to know that I will go on another crazy meth run again, and when I do I absolutely will be repeating the DXM dosing, both for the sake of science and to get higher off my dope.
This being a harm reduction site I feel obliged to say "Don't try this at home, these stunts are performed by experienced tweekers".
Last edited by leftwing; 31-10-2010 at 11:06. Reason: incriminating stuff
31-10-2010 11:07
^just be a little more cautious posting such things in the future. law enforcement check these boards remember?
31-10-2010 18:03
Well, articles are articles, research is research... But to be honest I've never experienced a substantial decrease in opioid tolerance if any at all in my life. I've never been an every day consumer of any NMDA antagonist, I really did such things occasionally but it didn't really have any impact on my intake of opioids (well, unless I shot morphine and ketamine together - well, but I'd rather say it was kind of synergy between two drugs and not any decrease in tolerance).
31-10-2010 18:26
DXM and memantine appear to work and we have good indications on what doses are effective, ketamine on the other hand has a very short half life wich could render it useless for this purpose, unless you really try to redose in time and do it chronically but thats rather impractical with ket.
21-11-2010 21:17
Can anyone move my thread to the advanced section?
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21-11-2010 21:21
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I'll talk it over with the other Other Drugs moderators and see if they are on board with the idea. I don't see any problem with doing so though.
I have always been impressed with your thread here, though I haven't had any practical purposes for it.
I was definitely impressed with both experiences and wasn't experiencing the high degree of synergy that I did.
21-11-2010 22:03
The reason i wanted it in advanced is because i can get some more scientific discussions going, the thread is dropping to the back all the time anyway, perhaps its a better idea to make a link to my thread in one of the informative sticky's on here with general info about drug use.
I also have experimented with MDMA the last 2 weeks and memantine helps a ton with the comedown, basicly no week aftereffects, just a bit skecthed out the day after.
21-11-2010 22:08
I wonder how NMDA antagonism would affect benzo withdrawal... Its largely speculated that the vast majority of benzo withdrawals are mediated through NMDA getting out of control... I've heard of people K-holing themselves for literally days at a time and making it through benzo withdrawal...
Unfortunately, getting ahold of memantine is proving difficult recently - I've been trying unsuccessfully for about a month now - because I would like to get off my benzos and anything that will help... but I'm not gonna shove myself in a permanent K-hole for a week.
21-11-2010 22:09
21-11-2010 22:13
Interesting... I'm on 40mg of valium a day and looking to get off as soon as possible - or at least knock the tolerance down to a point where I can taper much quicker...
It seems that NMDA antagonism is the way to go... but getting the memantine is the problem. (I edited that initial post).
And really, adding dope-a-max? Ugh.
21-11-2010 22:18
Here is he's experience:
I took Alprazolam for 3 years, then went through accidental cold-turkey withdrawal because the local pharmacies weren't carrying any (happens where I live occasionally, sucky country/city). I experienced severe withdrawal symptoms including paranoia and transient psychosis but soon I got again on Alprazolam and thankfully didn't have a seizure. During that period I was completely tolerant to 2 mg Alprazolam's both sedative and anxiolytic effects.
Since I started taking Memantine, the tolerance was reversed somewhat and 1 mg was anxiolytic and practical enough for social anxiety disorder. 2 mg was very effective sedative. Tolerance didn't develop any further from this point on.
When I began tapering off Alprazolam for good, I was on 2 mg/day and the withdrawal was pretty negligible, only symptoms were irritability and slight sense of panicking, despite the rapid taper process.
23-11-2010 02:15
Bump! I would like to get a few things discussed in the advanced section
23-11-2010 13:49
I've got 240 pills of "Namenda" (memantine) on the way... going to start with 10mg for 2 days to see how the brain fog is, then bump it to 20mg for a week - I have a feeling that is all that I'm going to need. Then when my valium suddenly knocks me on my ass I'm going to drop the dose by 10mg and see how I feel... if I'm still getting knocked out after a few days, I'm going to drop it again - by 5mg this time... even a 15mg cut in 2 weeks would make me supremely happy.
I can do DXM too - it seems like people are using 60mg of Delsym? Would this be favorable as well? Or just do ONE NMDA antagonist? lol. I really want off of these fucking benzos!
23-11-2010 15:19
Well my mate only noticed a reversal of benzo tolerance after he went up to 30-40mg of memantine, you can augment mem with some DXM to get the same results of a lower dose.
24-11-2010 02:24
Well I started Delsym today. 30mg every 12 hours I imagine?
24-11-2010 15:48
Updating. I ended up taking 60mg Delsym at 2PM yesterday, 60mg at 4:30AM or so this morning.
I ended up passing out some time around midnight and didn't take my valium. Upon waking at 4:30 I would normally be in mild withdrawal (half-life means nothing with my body - my metabolism is ridiculously fast) but I actually wasn't and I didn't take any valium until about 30 minutes ago when I took 10mg instead of my usual 20mg.
My morning cigarette really hit me hard too. Like I smoked half of it and when I went back in the house, I was quite dizzy and had a huge nicotine rush but ironically I didn't have my heart rate start pounding like it normally would if I had such a rush.
The NMDA antagonism is already starting to work its magic. The valium is kicking in faster and I've actually got some euphoria creeping in from it and its making me tired. This is astonishing - I've never gotten euphoria from any benzo except Xanax before - and I only got that when I first started to take it. The valium at half the dose is making me want to take a nap - and I just woke up - there really is a lot more than placebo to this!


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Body differences?
Looking to put a body kit on my '98 Cabrio and a guy told me that there were a few body design differences between the same year Golf and Cabrio. Has anyone kitted a Cabrio yet? How much modification will need to be made?
2 Answers
Theres a few things you can do... as in body kits theres only a few and not that good looking... But ill give u a few ideas... you can Swap the Jetta front end with your front end.. you can also change the hide lights... The golf and cabrio or mostly the same. Also you can put a Euro Front Lip on it to make it have that agressive look. Check out a magazine like euroturner or there website will give you lots of ideas i had a 96 jetta and i changed the front end to the golf all i needed to do was to change the hood...lights and grills.
I was hoping to find a way to hide the weld marks below the door where it looks like they cut a golf in half.
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Ryan's Reviews > The Last Detective
The Last Detective (Elvis Cole, #9)
by Robert Crais
by Robert Crais
Ryan's review
bookshelves: crime, drama, suspense, thinker, heard
Aug 25, 2009
bookshelves: crime, drama, suspense, thinker, heard
Read in September, 2009
I'm starting to get into these Elvis Cole books by Crais. No I'm not reading/listening to them in order. I'd have to be much more patient than I am in order to do that. The only reason I don't give this book the full 5 stars is the fact that I had a pretty sound theory worked up about what was going on a long time before Cole figured it out. I know that's the case sometimes, if not oftentimes, with mystery readers, but it was sometimes painful to know that I thought I had something figured out before the "world's greatest detective". The other reason I'm getting into these books is Joe Pike. Joe is Elvis's sidekick, backup, partner, etc. Basically he's a real bad ass. Kinda like the Terminator in many ways (the Arnold version, not those other 'more advanced' silly ones). From what I understand Joe's popularity has brought about his own series of books. I hope to get my hands on some of those soon!
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The first clear day after a week of clouds and rain allowed this beautiful sight to be captured. As much as 7 feet of snow fell in the mountains of Arizona this week. This photo was taken just as the noon-time fountain show took place at the center of Fountain Hills. The plume rises over 500 feet (150m) and is just ove...
Showing the farming that continues to go on in the canyon today as it has for hundreds of years.
A short loop walking trail passes among many petrified trees next to the Rainbow Forest Museum at the southern end of the park.
The Superstition Mountains form the backdrop for this annual event in the desert east of Phoenix. In the center of the parking lot cars are baking in the 85 degree sun. It's only March and still pretty cool. ;-) Single row, handheld, Canon T2i with 28-135mm set to 73mm.
Early morning look across green fields at the snow-capped mountains. Mt. Baldy, Mt. San Gorgonio and Mt. San Jacinto rise above the early morning haze. Lots of rain has turned all the countryside green this winter. Located at the intersection of I-215 and Scott Rd.
Even though I spent the first 19 years of my life within 15 miles of this building, I never got a good picture of it, nor did know what was inscribed above the entrance, extracted from the founding charter of the British Colony of Rhode Island in 1663: "To hold forth a lively experiment, that a most flourishing ci...
The Superstition Mountains form the backdrop for this annual event in the desert east of Phoenix. A few weeks back they were dusted with snow, but recent 80+ temperatures have melted it all. Single row, handheld, Canon T2i with 28-135mm set to 70mm.
Three aircraft carriers, USS Midway Museum close by and the USS Carl Vinson and USS Ronald Reagan across the harbor.(This is the right side of a larger pan that would not stitch a repetitive patterned facade of a high-rise building)
The sprawling Phoenix metropolitan area viewed from the Buena Vista Lookout and trail head. From here you can see all the major landmarks and sports facilities ranging from University of Phoenix Stadium to Sun Devil Stadium. The tall buildings of downtown are close to USAirways Center and Chase Ballpark. Notable mounta...
Food is a big attraction at this annual event, especially the smoked turkey legs. I know there are at least 3 of them in this pan. Can anyone find them? Single row, handheld, Canon T2i with 28-135mm set to 30mm, shooting while scanning quickly to the right at about 1 FPS in order to try and capture a scene with movi...


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OK here are a few more:
Buttercup; Countryman, The; Buff Beauty; Benjamin Britten (my camera doesn't do that color well--the one on the left is most true to color), and Dorothy Perkins.
Alpha-rose parade B-D
Nola_Nigella Circle, MT(Zone 3b) Jan 23, 2013
terri_emory Alba, TX(Zone 8a) Jan 24, 2013
Why thank you, Nola.
Do you have some to post? ☺
Nola_Nigella Circle, MT(Zone 3b) Jan 24, 2013
Mine are still so tiny, none yet have flowers, but I'm enjoying the parade!
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Project Description
I have a real estate website that I need to have implemented in joomla. I have a design in psd format created with reference viewports for fullscreen, tablet and mobile for several different layouts of the website. I have a joomla real estate component that works out of the box and just needs styling along with the template.
I want someone to code a a framework called T3 in joomla: [url removed, login to view]
The ideal and successful bidder must have the following:
-experience with Joomla
-experience with bootstrap
-strong jquery and jquerymobile skills.
-MUST code in HTML5
-MUST code CSS using LESS (faster development and better cross platform support).
-MUST make the design friendly for fast loading (css image sprites, etc).
-a strong portfolio of ACTIVE running coded work will be compelling in my decision.
I have a design I can show, but I do not want to put it on here for everyone to see. Put your best bid forward, and if I like what I read and am thinking of selecting you I would give you a chance to see the design and discuss any questions I may have via skype before the awarding/accepting of the bid.
If we have a good experience on this go around, I am loyal to those who do good work for me.
Skills Required
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- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
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Danish Early-career Translators (Part-time Job/ EUR 60 per day)
Andovar is seeking a number of early-career translators/students to work on a large translation project for a leading online hotel booking. The project is to translate 2 million English words into Danish. The content is very simple and consists of hotel room names and short booking notes.
This is freelance and work from home position: you must have a reliable internet connection and computer. We can provide candidates with the workload that suits your availability.
Requirements:• Be a native speaker of Danish• Translation experience is not required• You must own a computer with an internet connection
Translator• Translators should expect to manage appx 3,000 to 5,000 words per day of straightforward content• Glossary of hotel terminology provided.
Offer pay: up to EUR 60 per day, depending on productivity
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