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The Challenges of Harmonizing Biomarker Data
Why Trial Success Depends on It
Top 10 Wall Street Losers of 2016
These Companies Lost the Most in a Down Year for Biopharma Stocks
Reading miRNAs for Clinical Meaning
Single miRNAs Don't Say Much, but They May Become Eloquent Biomarkers if We Take Their Testimony in Context
Sorting Out the CRISPR Patent Case
Sounds of Science Podcast
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January 15, 2008 (Vol. 28, No. 2)
Biobanking Needs More Standardized Procedures
Personalized Medicine Brings Unique Requirements for Managing Specimens
- The importance of standardizing conventions for storing biological samples is becoming increasingly obvious, and the growing need for standardization was the focus of Informa Life Sciences' "Biobanking and Biorepositories" conference held in Munich in November. Attendees from national biobanks, pharmaceutical companies, and key industry and government bodies came ...
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- Do not put any letters or characters here if you are not a spy program.

subset: commoncrawl


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Time Warner Cable York South Carolina, From one company for a surprisingly low price, three great services. Let's take a look at Time Warner Cable Digital TV, Road Runner® Broadband, and Digital Home Phone to see why these services offer the best combination of features and value available! Three great services, one low bill – You do the math. You will get a discount for choosing all of the services as a bundle and you will have everything billed in one convenient monthly payment.
Time Warner Cable York – Call or Order Online
A Time Warner Cable DVR lets you and your family focus on the shows you care about most, so all your TV time together is quality time. With features like Start Over®, Look Back®, and On Demand, you'll never miss a show again.
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Get over 200 all-digital channels so you don't miss a thing! Time Warner Cable South Carolina, SC With all the programming you receive from signing up with Time Warner Cable, there are bound to be shows not meant for a young audience.
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Viewing pictures, music, movies, and videos has never been faster or easier than through Time Warner Cable Road Runner® Broadband. The fastest Road Runner ever, Road Runner Turbo adds a lot more speed, better gaming and faster file sharing for an additional $10 more per month. Only Road Runner has PowerBoost®, which can give you an extra burst of speed when downloading big files so videos, music and files go even faster than before and you spend less time waiting. Road Runner® Broadband has a variety of standard security features.
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Include Time Warner Cable Digital Home Phone Service along with your Digital TV and Road Runner® Broadband to complete your telecommunications needs. Time Warner Cable South Carolina There's no need to buy unnecessary and expensive new telephones or equipment, because Time Warner Cable Digital Home Phone plan is compatible with your current telephones and phone jacks. Unlimited Nationwide calling plan enables you to make phone calls to anywhere in the United States, Puerto Rico, and Canada for a single low monthly rate.


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Alice in Wonderland (Animated) [U]Jef Films [Blu-ray]
Only 2 in stock
DescriptionChildren's animated adventure adapted from the classic Lewis Carroll novel. This version of Alice's journey down the rabbit hole to a world of wonder and intrigue, combines clips from a rare 1945 radio recording, which starred Dinah Shore, Arthur Q. Bryan and Ralph Moody, with modern animation.
Michael Conroy
Disc Features:
Interactive Menus
Product Details:
• Certificate: U • Format: Blu-ray • Number of Discs: 1 • Running Time: 57 minutes • Language: English
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- barcode: 5060195361817
- product type: general
- pack size: 1 Disc
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We do venepunture.
We do venepunture.
Thank you for the clarification on the suturing/cannulation issue. My info was from the two courses I am looking at (one a BMid, the other a dual) - I had just assumed that all BMids were "created equal", and that the skills gained at the end would be the same regardless of which program you went with. Very interesting!
So, new question for all the student nurses and midwives:
What is something that you wished you could have known before starting your course? This could be anything to do with the course itself, lifestyle changes etc etc. Any input much appreciated!
How mentally/emotionally draining doing prac is. Especially when your trying to complete assignments/study for exams.
How political midwifery was (Yeah I was a tad ignorant at the beginning)
How b*tchy the people in the hospital/program got.
That it doesn't matter how much the uni tells you that they care, are family-friendly, will always be there to support you etc at the end of the day their an educational institution and will follow those academic and program rules and regulations to the absolute letter.
Marks don't matter that much when it comes to getting a job (not that in the way that it would in Law etc). If you've been getting passes/credits in the theory work and have awesome clinical references then you'll get a job over someone with a GPA of 7.0 but isn't that good clinically. Noone really cares if you know the intricate details of cellular function of the digestive system, they'd much rather see you be able to care for a woman with confidence and knowledge.
Last edited by wannawannabe; 15-09-2012 at 14:55.
Very well said wannawannabe! I agree 100%
+ all programs are not the same. It's worth looking into the differences.
Ooooh yes - definitely about the programs!! Whilst you come out with the same degree each uni delivers it differently especially in terms of when and where you do practicals (e.g UQ we did 2-3 days a week instead of block placements and stayed at the one hospital for the three years) and you need to make sure it will suit you and your household arrangements
Anyone have any interview tips to share? Haven't had one yet but am feeling very nervous about it all. Writing a cover letter is also like doing an assignment! any tips welcomed
Cover letters should go something along the lines of.
dear boss woman
i wish to apply for a full time/part time graduate midwife position at awesome hospital. I am currently studying bachelor of mid at brilliant university in awesome town and will be able to commence work in February once I receive my spray registration.
I have spent my third year placement at awesome hospital working in antenatal clinic, birth suite etc and believe that awesome hospitals graduate program is the best pplace for me to develop me skills and experience as a newly qualified midwife. I received lots of support/loved working at awesome hospital and would love to return next year.
I have also completed placements at big scar y hospital where I worked in the high risk clinic and little lovely birth centre where I gained experience in low risk normal labour/birth. This wide range of experiences have given me solid grounding for practice as a grad midwife.
I also have worked at Coles for the last 5 years where I have developed excellent communication and problem solving skills which I have applied to my midwifery practice.
<<add in any selection criteria they wish you to address>>
I look forward to hearing from you regarding my application
Also quick question, did many of the Griffith girls get an interview at gold coast public? I didn't get short listed at all, and figured they probably only interviewing people who did prac there?
RE: GC interviews. Some Griffith students who didn't do their placement there applied but didn't hear anything either. But, the GC girls said they heard the hospital had selected applicants based on proximity to the hospital for interview. I also think that they are probably just interviewing from the people who did their placement there.
Pregnant for the first-time?
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text: Seller: photovintage (3,723) 99.7% , Location: Ocean City, Maryland, Ships to: US, Item: 252651251879 You are bidding on a wonderful set of antique circular rosette style drawer pulls. Three of the pulls have a diameter of 2.5 inches and the other three have a diameter of 2 inches. Excellent condition. Great for your restoration project. Excellent condition. I ship worldwide. Email me with questions. Good luck. Condition: Excellent condition, Color: Patina, Material: Brass or bronze


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3 'terrorists' arrested in Quetta
by Daniyal / Monday, 02 February 2015 / Published in Balochistan, Terrorism
QUETTA: Security forces on Saturday arrested at least three suspected terrorists in Sariab area during an operation.
According to security officials, the terrorists belonging to a banned outfit were arrested during a search operation. Arms and ammunitions were also recovered from the possession of the arrested suspects. Meanwhile, in another search operation law enforcement agencies apprehended three suspected persons from Kapoto area of Kalat district.
The original article can be found at Daily Times.
Tagged under: apprehended, arrested, Daily Times, pakistan criminal check, Quetta, recovered, Sariab area, Search Operation, suspects, Terror War, Terrorism, Terrorists, War on Terror, War on Terrorism


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Showbiz Sandbox 333: Predicting The Biggest Box Office Flops of 2016
August 31, 2016
Much has been made about the decline in box office this summer, with franchise sequels underperforming and certain pricey movies failing to attract an audience. Kevin Lincoln, a senior editor at New York Magazine and Vulture, takes a look at this summer's biggest flops and predicts which mega-budget releases might suffer a similar fate as we round out the year.
In China it might be more difficult to know which movies are box office disappointments or crowd favorites since online and mobile ticketing companies have been offering hefty subsidies to cinemagoers in their heated battle for market share. This means the gross of any release is almost always higher than what moviegoers actually paid to see it.
We'll also dip back into audience figures from the recently completed Summer Olympics in Rio. This time however we have some data about viewership in Europe, Canada and elsewhere. To nobody's surprise, more people streamed coverage online than ever before.
Of course we also cover the week's top entertainment news including how Netflix international subscribers will soon outnumber those in the United States, a changing of the guard at Twentieth Century Fox gets expedited and the late Prince's home and music studio is set to become a museum.
Podcast: Play in new window | Download
Showbiz Sandbox 325: Keeping Track of Who's In Charge at Hollywood Studios
June 20, 2016
It would seem keeping one's job as a senior executive at a major Hollywood movie studio has become much harder of late. Last year both Paramount and Sony Pictures replaced their studio heads. Now the executive shuffles at Sony and Fox, as well as the turmoil at Viacom, have our heads spinning. We'll be joined by Anne Thompson of Indiewire who explains why Hollywood is in turnaround.
We also breakdown the past week's worldwide box office, where a little fish swam a long way. Apparently audiences hadn't forgotten the forgetful character from "Finding Nemo" and thus turned the Pixar movie "Finding Dory" into a box office smash.
Amazon plans to expand its streaming music service, but will it be worth listening to? Meanwhile, CBS won a potentially significant lawsuit when it argued successfully that a remastered album can in fact be considered a brand new work in terms of copyright.
Of course we also cover the week's top entertainment news including the Tony Awards telecast get a ratings bump, Disney opens a theme park in Shanghai and ESPN devotes itself to soccer (or football, depending where you live).
Podcast: Play in new window | Download
Showbiz Sandbox 323: Trends From the 2016 TV Upfronts
May 30, 2016
Each May all the U.S. television networks invite major advertisers and the media to New York so they can pitch all of the new and returning shows on their fall schedules. Known as the upfronts, a good chunk of the prime time advertising inventory is sold during these meetings as promotional buzz about each series commences in earnest. We'll take a closer look at some of the big trends coming out of this year's upfronts.
Meanwhile, a much beloved series might be starting a trend of its own by increasing viewership in its 12th season. Usually long-running shows lose audience in their latter years, however "Grey's Anatomy" is the perfect example of how new technology can boost viewership.
Viacom and CBS are likely to have kept a close eye on the recently completed upfronts, given their dominance in television. CBS was originally a Viacom property, but was spun-off more than a decade ago. Now, amidst leadership turmoil at Viacom, there is speculation the two companies may merge, once more becoming a single entity.
Of course we also cover the week's top entertainment news including why U.S. presidential candidate Bernie Sanders is criticizing Disney, Spotify's big success in helping subscribers find new music and why the next James Bond film is in search of a director.
Podcast: Play in new window | Download
Showbiz Sandbox 320: Is Comcast the New Disney?
May 2, 2016
Comcast announced last week that it would acquire Dreamworks Animation for $3.8 billion, taking another step toward transforming themselves from a cable giant into a full fledged media conglomerate. Meg James, a corporate media reporter for the Los Angeles Times, join us to discuss how, though the deal may not have been anticipated, it makes a lot of sense for both companies.
The purchase is the most recent in a string of acquisitions that have closely mirrored the strategy Disney has executed over the past decade as they gobbled up companies such as Pixar, Marvel and Lucasfilm. Comcast has proven quite adept at turning undervalued assets such as NBCUniversal and Universal Studios theme parks into profitable entities.
Meanwhile, as the Tony Awards season officially kicks off, Broadway is suffering from what is being referred to as The Hamilton Effect. This is a condition in which you open a musical that blends hip-hop and history in a way that not only makes the show a cultural phenomenon, but the inevitable winner of this year's much coveted Best Musical Tony.
Of course we also cover the week's top entertainment news including the Daytime Emmy winners, why Fox is pulling out of this year's Comic-Con convention and how French law enforcement is preparing for the Cannes Film Festival.
Podcast: Play in new window | Download
Showbiz Sandbox 319: The Changing Tide of Music Distribution
April 25, 2016
Almost three years after Beyoncé made a big splash by releasing a secret album via iTunes, the pop star has snuck up the world once again with her latest work, a video album called "Lemonade". This time however Beyoncé was strategic in how she distributed her album, premiering it with an HBO special, then exclusively to the streaming music service Tidal, before ultimately turning back to iTunes. More and more, big name acts are controlling how and to whom their music gets distributed.
Multi-genre musician Prince was way ahead of his time when it came to controlling how his music reaches the world. The legendary artist died suddenly last week leaving behind a lifetime of work a great deal of which was never released. We discuss the many fascinating ways the unexpected death of Prince was covered by the media and his sometimes unique distribution methods.
We'll also take a look at the introduction of a new cinematic camera that has the potential to revolutionize filming and post-production by allowing to filmmakers "to effectively capture the color, direction and placement of every ray of light".
Of course we also cover the week's top entertainment news including some behind the scenes drama at the morning talk shows, why China shut down some of the Apple iTunes stores and how Hollywood is making its way to West Africa.
Podcast: Play in new window | Download
Showbiz Sandbox 301: The Current Reality of Virtual Reality
November 9, 2015
Until the past few years virtual reality felt more like actual fiction, as proponents offered up underwhelming demonstrations which requiring expensive and cumbersome equipment. The days however, the ongoing work by the pioneers developing VR has transformed the technology into a viable platform for more than just the odd hardcore gamer.
As VR products and content make their way into the consumer market, it seems no industry trade show or film festival is complete without addressing the technology in some way. In fact, just last week, the Sundance Institute announced they would begin a residency program in VR and the New York Times launched their own VR initiative. We dive into the hype behind VR and try to make some sense out of what all the fuss is about.
Meanwhile, as the MPAA confirmed a new agreement for film distribution in China, and with the country on track to surpass North America as the world's largest movie market in 2017, a number of organizations are claiming China isn't abiding by international trade rules to which it had originally agreed.
Of course we also cover the week's top entertainment news including the nominees from this year's European Film Awards, Showtime's plans for the revival of "Twin Peaks" and why a number of police departments are calling for their officers to boycott Quentin Tarantino's upcoming movie.
Podcast: Play in new window | Download
Showbiz Sandbox 286: The 2015 Mid-Year Box Office and Music Sales Report
July 6, 2015
With the year now half over we join the rest of the entertainment industry in reviewing how 2015 is shaping up at the box office and for music sales. As predicted, the worldwide box office is on track to set another annual record thanks in part to three blockbuster releases that have each earned more than a billion dollars.
China continues to be an ever more important movie market as the country's box office surged more than 50% during the first six months of the year with imported titles leading the way. Meanwhile, Hollywood movies have fared better in India than in past years with two passing the billion rupee level, a well-established benchmark of box office success.
The picture isn't as rosy when it comes to music revenue. North American album sales are down 4% and digital downloads have fallen more than 10%. The declines may be caused by on-demand music streaming which has increased 74% so far this year. Whatever the reason, Taylor Swift isn't sweating it since her most recent album has sold more than 2 million copies this year alone.
Of course, we also cover the week's top entertainment news stories including the Grateful Dead perform one final concert, massive layoffs at the BBC and HBO Now is a huge hit in the iTunes app store.
Podcast: Play in new window | Download
Showbiz Sandbox 226: Back To The Future – Why TV Networks Suddenly Love Old People Again
February 24, 2014
Broadcast television networks are finally catching on to what most of us have known all along; people over the age of 50 actually watch a lot of TV. In a never-ending pursuit to attract younger viewers, networks discovered that baby boomers make up a large portion of their audience. Surely we'll be seeing a lot more programming meant to appeal directly to this new found demographic.
Maybe some of these new, more mature shows can be turned into movies one day. That seems to be the new trend in Hollywood as studios get set to release two movies that are spun-off from canceled series ("Veronica Mars") or are have actually already appeared on television as mini-series ("Son of God").
Speaking of Hollywood studios, it turns out that despite crying poor on a perennial basis, they all managed to make hundreds of millions of dollars in profit during 2013. Not revenue… actual profit.
Of course, we also cover the week's top entertainment news stories including Cee Lo Green quitting "The Voice", CNN quitting Piers Morgan and the end of Moviefone's movie listing service.
Podcast: Play in new window | Download
Showbiz Sandbox 208: Why Studios Are Reshuffling Their Executive Ranks
October 7, 2013
Movie moguls have always faced unreliable job security, though never more so than over the last two years. Beginning in early 2012 five of the six major Hollywood movie studios have fired their top executives and reshuffled existing management. We discuss what's causing the studio shakeup and it it will affect the movies we see in years to come.
Soon enough unemployed studio big shots may be able to find work in South Korea's film industry. With a wave of fresh homegrown talent and exciting new stories finding their way into theaters, the country's box office has skyrocketed making it one of the world's strongest movie markets.
When it comes to box office on Broadway, it's become a tradition for productions to boast when they've broken even. This also means we can do some quick math to conclude how much it costs to keep a show up and running on a weekly basis, a figure that many productions don't always like to share.
Of course, we also cover the week's top entertainment news stories including David Letterman's new late night contract, New York City Opera files for bankruptcy and a jury decides a concert promoter is not liable for the death of Michael Jackson.
Podcast: Play in new window | Download
Showbiz Sandbox 195: Hollywood Exploits 9/11 Imagery For Its Implosive Blockbusters
June 19, 2013
As "Man of Steel" sets the worldwide box office aflame, the latest Superman reboot also serves as yet another example of a Hollywood blockbuster exploiting the imagery of 9/11 for apocalyptic purposes. Kyle Buchanan, the Movies Editor at New York Magazine, would like to see filmmakers stop relying on meaningless urban destruction. He joins us to discuss his recent article calling for an end to the "orgy of gratuitous building-battering" in big budget movies.
Steven Spielberg and George Lucas are two filmmakers quite familiar with blockbuster movies. Now, the directors who helped launch the modern day tentpole release are predicting an "implosion" for Hollywood, along with a handful of other pessimistic prognostications. We'll tell you what they had to say in a recent panel discussion.
Last week also saw Apple finally get into the music streaming business with the announcement of iTunes Radio. Only time will tell whether Apple will be able to compete with Pandora, Spotify and all of the other existing players in the space, though we're not overly impressed.
Of course we also cover the week's top entertainment news including a legal victory for Hollywood interns, Arnold Schwarzenegger returns to "The Terminator" and The Muppets head to Broadway.
Podcast: Play in new window | Download


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"What a view! The Shangri-la Hotel." The Rocks Tip by islandtaryn
The Rocks, Sydney: 91 reviews and 147 photos
About two blocks from the Rocks you will find the Shangri-la Hotel. On the 36th floor there is a bar with what may be one on the best views of Sydney Harbor.
The drink menu is incredible! I had something called 'Toblerone' (like the candy). It was decadent! Kahlua, honey, and a mixture of both white and dark chocolate shavings. There was so much chocolate, I had to finish it with a spoon!
Address: Circa Circular Quay
Directions: Walk up the hill behind the Rocks. There is one entrance on Harrington St. I can't remember the street name for the main entrance but it's one more block up the hill above Harrington.
Phone: +61 2 9240 8500
Website: http://www.therocks.com/
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Neoadjuvant trials provide endpoints, such as pathological complete response (pCR) to treatment, that will potentially translate into meaningful improvements in overall survival and disease-free survival. Neoadjuvant trials need smaller sample sizes and are less expensive, and the endpoint of pCR is achieved in months, rather than years. For these reasons, the neoadjuvant setting is ideal for testing emerging targeted therapies in early breast cancer. Recently the US Food and Drug Administration has released a draft Guidance to Industry, outlining a pathway to accelerated approval for neoadjuvant breast cancer therapies using pCR. The association between pCR and outcome is clear for chemotherapy in triple-negative breast cancer and for HER2-targeted agents in HER2-positive disease, but might not hold true for other tumor subtypes such as luminal cancers. Since pCR is rarely achieved with either chemotherapy or endocrine therapy in hormone-receptor-positive breast cancer, in this setting we need to identify different intermediate endpoints, which might be translational endpoints within "window-of-opportunity," "residual disease," and "genome forward" trials. Prospective validation of effective noninvasive techniques for monitoring of residual disease burden could enhance the ability to identify promising targeted therapies in the neoadjuvant setting.
Breast cancer subtypes are characterized by specific molecular events. Genome-wide sequencing studies will increase our understanding of cancer biology and will identify two specific types of molecular events: the "drivers," providing a survival- and proliferation-selective advantage, and the "passengers," neutral to the selection process. It will be essential in the future to identify all molecular pathways that emphasize the heterogeneity and complexity of human breast cancer to explain mechanisms sustaining proliferation hallmarks of cancer and "drive" tumor progression and resistance to therapy. Disease segmentation in subtypes can offer insights to personalize treatment and the neoadjuvant setting is ideal to explore "hypothesis driven" studies. The main challenge of personalized therapy is to distinguish which patients will benefit most from a particular targeted agent from those who will not. The neoadjuvant model provides a powerful tool to better understand breast cancer biology, to detect and validate surrogate biomarkers, and to accelerate evaluation of new active drugs. We analyze the reasons for which the neoadjuvant setting should be used as a model for testing emerging targeted therapies in breast cancer.
Rationale for Drug Development in the Neoadjuvant Setting
Drug development through traditional phases in advanced-disease setting is a long and expensive process. Recently the US Food and Drug Administration (FDA) outlined a new pathway for accelerated drug approval through neoadjuvant trials (1). This pathway needs to reconsider some of the current approaches to clinical trial design. The neoadjuvant trial model provides a great opportunity to test the efficacy of new targeted agents in patients with previously untreated disease and allows to detect the subgroups of patients and tumors in which they are most effective. In the neoadjuvant setting the tumor remains in its microenvironment and is accessible for pre- and postexperimental treatment biological assessment through tissue biopsy, offering a real-time examination of tumor response and pharmacodynamics of experimental agents. The pretreatment biopsy will allow the potential identification of predictive biomarkers of response. A seminal study by Ellis et al. (2) assessed the great opportunity offered by the neoadjuvant model. To correlate the variable clinical features of estrogen-receptor-positive breast cancer with somatic alterations, they studied pretreatment tumor biopsies accrued from patients treated with aromatase inhibitor in two neoadjuvant studies by massively parallel sequencing and analysis. Eighteen significantly mutated genes were identified, including five genes (RUNX1, CBFB, MYH9, MLL3, and SF3B1) previously linked to hematopoietic disorders. Mutant MAP3K1 was associated with luminal A status, low-grade histology, and low proliferation rates, whereas mutant TP53 was associated with the opposite pattern. Moreover, mutant GATA3 correlated with suppression of proliferation upon aromatase inhibitor treatment (2). In another study, investigators performed messenger RNA gene expression analysis from pretreatment core biopsies of patients treated with ixabepilone (3). Gene expression data were available for 134 patients. Estrogen receptor (ER) gene expression (ESR1) was inversely related to pathological complete response (pCR) in breast and had a positive predictive value of 37% and negative predictive value of 92%. A 10-gene penalized logistic regression model developed from 200 genes predictive of ixabepilone sensitivity in preclinical experiments included ER and tau and had higher positive predictive value (45%) and comparable negative predictive value (89%) to ER1 (3).The tissue biopsies obtained during the neoadjuvant treatment can be useful for correlating changes of biomarkers with potential outcome. The presence of high Ki67 expression after 2 weeks of neoadjuvant endocrine therapy for estrogen-receptor-positive breast cancer was statistically associated with lower recurrence-free survival (P = .004), whereas higher Ki67 expression at baseline was not (4). The neoadjuvant setting offers also the chance to consider the pCR as a surrogate endpoint of outcome in triple-negative and HER2-positive breast cancers (5,6) and provides a strong rationale for testing new biological drugs. Based on the assumption that pCR can be used as an endpoint for a fast assessment of drug efficacy, thus allowing to save both time and money compared with conventional adjuvant trials, the FDA in 2012 released a draft guidance declaring that the agency would evaluate granting accelerated approval on the basis of pCR as surrogate endpoint of clinical benefit in neoadjuvant setting. FDA requires, after the accelerated approval, the demonstration of an improvement in disease-free or overall survival, pending the withdrawal of the indication from product labeling if confirmatory trials will not show a clinical benefit (7). Recently, the FDA approved the use of pertuzumab for neoadjuvant treatment of patients with HER2+ breast cancer (8) and this is the first example of FDA-approved drug for neoadjuvant treatment based on pCR as primary outcome (9). Therefore, the neoadjuvant setting could be used as a rapid tool to test in vivo a biological hypothesis and to demonstrate the potential activity of a specific drug.
Window-of-Opportunity Trials
The introduction of targeted agents in the treatment of breast cancer has resulted in new challenges for assessing response to therapy, in fact conventional response criteria are limited and may lead to misleading conclusions about a drug's benefit. On the other hand, assessing biological endpoints can be limited by difficulty in obtaining tumor tissue before and after drug administration and by exposure to previous anticancer therapy (Figure 1). The window-of-opportunity (presurgical or phase 0) trials represent a tool to bypass these issues. In this model, a study drug is administered to women with newly diagnosed breast cancer in the time between the diagnostic breast biopsy and scheduled surgical resection. The phase 0 trials provide investigators with the opportunity to obtain tumor samples at two distinct time points and assess potential biomarkers over a short period of time. Therefore, the presurgical trials allow to evaluate quickly the pharmacokinetic and target modulation of a novel agent and provide the early demonstration of potential clinical activity of a new drug. The validation of the proliferation biomarker, Ki67, as an intermediate endpoint (4) allows using it as an appropriate surrogate marker of outcome instead of clinical response. In patients randomized in the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) trial (10), a decrease in proliferation activity, as assessed by Ki67 expression, was found to happen after only 2 weeks of therapy and was an independent predictive factor for relapse-free survival (11). A higher inhibition of Ki67 was detected in the anastrozole arm as compared with tamoxifen or to the combination, anticipating the results of the large adjuvant Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial (12). In the study by Guix et al. (13), women with operable breast cancer were treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib and the results indicated that short-term treatment with erlotinib inhibited tumor cell proliferation and inhibition of proliferation occurred in ER-positive breast cancer outside of the epidermal growth factor receptor-overexpression group. Compared with pCR, changes in tumor biology were found to occur already a few days after treatment start (4). This is an important advantage because it may lead to early adjustments of individualized treatment. For this reason, biomarkers of proliferation are widely used as endpoint of outcome also in the ongoing phase 0 trials testing novel targeted agents, such as the MONALEESA-1 trial, a randomized presurgical study that will assess the biological activity of LEE011 (a CDK 4–6 inhibitor) plus letrozole versus single-agent letrozole in primary breast cancer (14). However, Ki67 has proven to be an appropriate surrogate marker for outcome in preoperative studies administering endocrine therapies (4,15,16) but may not be the most suitable endpoint for predicting outcome for other targeted therapies do not having a direct antiproliferative effects such as antiangiogenic agents. The presurgical approach with targeted agents has also other challenges, such as the optimal duration of the treatment window to detect measurable variations in the surrogate endpoints without delaying standard clinical management, the intrinsic variability, and heterogeneity of tumors—that may be underestimated in a limited tissue sample—and the safety, given that most patients are potentially curable by surgery alone.
Residual Disease Trials
Not all patients treated with neoadjuvant chemotherapy do achieve pCR (17). In this population the study of residual disease and the evaluation of biomarkers modifications induced by the treatments is becoming of great interest as it allows identifying potential markers of treatment resistance and offers new development fields of molecular target agents. Some trials are ongoing in the residual disease setting for patients not achieving pCR after neoadjuvant treatment (Figure 2). Based on data of EMILIA study, which demonstrated that trastuzumab emtansine (TDM-1) improved survival of patients with HER2-positive metastatic breast cancer (18), a global trial (KATHERINE NCT 01772474) is evaluating TDM-1 as an alternative to continuation of trastuzumab in women with residual disease following neoadjuvant chemotherapy (19). Based on the results of a randomized phase II study that demonstrated an improved progression-free survival in patients with hormone-receptor-positive metastatic breast cancer (20), palbociclib (PD-0332991), a cyclin-D kinase 4/6 inhibitor, is being tested in addition to endocrine treatment in patients with a high clinical-pathological stage (CPS) + estrogen receptor status (E), grade (G), staging (CPS-EG score) (21) and no pCR (PENELOPE study) (22). The Hoosier Oncology Group is assessing the benefıt of cisplatin with or without a PARP inhibitor, rucaparib (Clovis), in women with triple-negative or ER-positive/BRCA mutant breast cancer who have residual disease in the breast after neoadjuvant chemotherapy (NCT01074970) (23). If successful, these trials would institute a new approach for drug development. Molecular and genetic profiling of residual disease after neoadjuvant therapy is an exciting field of study because it allows to address new agents against potential targets of resistant disease with the opportunity to improve outcome for patients with poor prognosis after standard therapy.
Genome Forward Trials
The development of high-throughput sequencing technologies improved knowledge of genetic alterations that underlie breast cancer and induced advances in the field of therapeutic researches. The detection of new predictive biomarkers together with the implementation in drug development is generating a new era of clinical studies in which the patients' enrollment is stratified based on biomarkers that could potentially predict and augment the response to targeted therapy. In the genome-driven or "genome forward" neoadjuvant trials the activity and efficacy of new drugs are prospectively tested in a population defined on the basis of specific biomarkers that might be useful to target identification and to understand the resistance mechanisms (Figure 3). An interesting feature of these trials is an early response evaluation in which the biopsies and imaging assessments provide the opportunity to understand biology of response and resistance to new targeted agents and, accordingly, to continue the treatment only in the subgroups of patients in which a tumor growth arrest is obtained. An example of biomarker-stratified trial is the ongoing I-SPY 2 neoadjuvant trial, a randomized phase II trial designed to assess the incremental benefit of new targeted agents added to conventional chemotherapy (24).
In the screening phase of I-SPY2, potential candidates undergo core breast tumor biopsies for screening which includes MammaPrint along with ER, PgR, and HER2 assessment. Patients who are ER+/MammaPrint high, ER−, or HER2+ are eligible for the study. Eligible patients are then randomized to either standard neoadjuvant chemotherapy with weekly paclitaxel (plus trastuzumab for HER2+) or paclitaxel combined with one of several investigational agents followed by four cycles of doxorubicin/cyclophosphamide. Biomarkers are used to identify signatures for experimental regimens. The primary endpoint is pCR at the time of surgery. Patients on treatment undergo serial tissue collection and imaging. Regimens are dropped if they do not improve pCR rates for any biomarker signature. The adaptive design of this trial, selecting the subgroups of patients more responsive, allows accelerating the investigational agents' development into subsequent phase III trial, to increase the efficiency and to limit the exposure to potentially harmful drugs. In another ongoing trial, patients with clinical stage II or III luminal-type breast cancer (ER+ HER2− breast cancer) are biopsied at baseline for PIK3CA gene sequencing. They receive an estrogen deprivation therapy (aromatase inhibitor plus an LHRH-A if premenopausal). After 28 days, the patients with PIK3CA mutant tumors will be eligible to receive an AKT inhibitor (25) and those with PIK3CA wild-type tumors will be eligible to receive a CDK4/6 inhibitor trial (26). Repeated tumor biopsies will be taken before the start of either MK-2206 or PD-0332991 on cycle 1 day 1 and after 2 weeks of combination therapy for the evaluation of early response biomarkers (Ki67). Those with resistant tumors (Ki67 >10%) will go off therapy early to avoid futile treatment. Those with Ki67-responsive tumors (Ki67 <10%) will receive a total of 4 months of study drug therapy followed by definitive breast surgery to evaluate pathological response. The genome forward trials are the challenge of the future and could provide the answers to the request of patients to receive personalized treatments.
The "Oncogene Revolution" has led to an explosion of molecularly targeted therapeutics in preclinical and clinical development over the last decade. It is estimated that there are more than 800 targeted anticancer therapies currently in various stages of clinical development. Disappointingly, historical data indicate that only 5% of these investigational agents will ultimately progress to registration for widespread use. These high attrition rates have multiple causes, including lack of efficacy and excessive toxicity. In particular, when patients are selected for phase III trials based on histopathology alone, a targeted drug with a 5%–10% single-agent response rate runs a high risk of failure. Recent efforts to systematically sequence cancer genomes have revealed that individual tumors frequently harbor multiple "driver" somatic mutations that confer growth advantage and positive selection. The increasing identification of specific somatic mutations and other genetic aberrations that drive cancers leaves us on the threshold of a new era of "personalized cancer medicine," in which specific biomarkers will be used to direct targeted agents only to those patients deemed most likely to respond. The potential medical, scientific, and economic benefits of such a personalized approach to cancer therapy are immense and self-evident. The neoadjuvant setting offers a unique opportunity to accelerate this process. Testing new agents in potentially curable patients requires a series of considerations. Firstly, there is the need to carefully select the patients at higher risk who would not benefit from standard therapy alone and for whom is ethically rational an investigational therapy. Secondly, there is the need to find the appropriate surrogate markers of outcome for every novel agent and for every subgroup of breast cancer. For example, we know that pCR is a good surrogate of outcome in ER−\HER2+ and ER−\HER2− breast cancers but it is not helpful for patients with ER+ disease (27). It is not feasible a correct assessment of an increased benefit of a new agent in absence of a valid response marker. Finally, breast cancer is a multiclonal disease and a single biopsy might underestimate the molecular aberrations driving the cancer in each individual patient. For this reason, it is important to integrate the detection of mutations with other analytic approaches such as the "liquid biopsies." Correlation of qualitative and quantitative analysis of circulating DNA with pathological response to neoadjuvant therapy might anticipate potential resistance to biological agents and allow to early switch to non-cross-resistant therapies (28). Processes to identify which drugs and methods are appropriate to evaluate toxicity in real time are the cardinal point to do not lose the right way in the neoadjuvant model. Proof-of-concept clinical trials that establish the value of matching targeted treatments to rare molecular alterations in breast cancer and other malignancies is beyond the scope of any single pharmaceutical sponsor, cancer treatment facility, or national cancer agency and will ultimately require international collaboration (29).
- polymerase chain reaction
- cancer
- chemotherapy regimen
- hormone
- genes, erbb-2
- genome
- neoadjuvant therapy
- receptor, erbb-2
- united states food and drug administration
- neoplasms
- phenobarbital
- breast cancer
- endocrine therapy
- residual tumor
- surrogate endpoints
- complete remission
- triple-negative breast cancer
- her2 positive
- molecular targeted therapy


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VideosIf you watch one YouTube video today, make it this one. You haven't lived until you've heard "Buy U A Drank" as a ballad.
5 Comments You must log in to comment, or create an account
FutureLobbyist 2 years ago
That legit surprised me, honestly expected a fucking tone deaf train wreck
Mr. Unproductive 2 years ago
Just proves T-Pain is a genius. He actually has talent but used auto-tune to distinguish himself from everyone else. Made millions. A true visionary.
ASpookyGhost 2 years ago
This is a great video and T-Pain is legitimately talented…
… But god damn I thought this website was above shitty clickbait article titles.


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Upon initial setup, iTunes will automatically search your hard drive for videos and music to add to your iTunes "Library" file. Afterwards, the iTunes software makes it easy for you to locate videos on your hard drive or download new videos to your library.
Things You'll Need
- Internet access
- Computer
- Apple iTunes
Move Videos Already on Your Computer to Your iTunes Library
Open iTunes on your computer by double clicking on the iTunes icon.
Click on "File > Add to Library."
Browse for video files. Search folders where you might have stored videos-try "My Documents," "My Videos" or "My Received Files."
Select one or more files and click "OK" or "Open."
You can also drag-and-drop video files from a folder (navigate folders with the "My Computer" or Windows Explorer feature) to the open iTunes window.
Buy Videos From the iTunes Store for Your iTunes Library
Click the iTunes Store icon in the "Source" list on the left of the iTunes window. Click the "Sign In" button to log in or start a new account.
Click the "Videos" link on the iTunes Store main page to summon a list of video categories and browse videos.
Click the "Buy" button to add a video to your shopping cart.
Click the "Shopping Cart: icon to review your order. If everything looks good, click "Buy Now." The videos will download and automatically appear in your iTunes "Library" file.
Tips & Warnings
- You can also search for videos in the iTunes Store, just like you'd search for songs on your library.
- When you download videos from Web sites, save them in a designated folder so you can easily find them.
- Videos occupy a lot of hard disk space. Delete any old videos and duplicates.
Related Searches
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House trained • Spayed/Neutered • Primary Color(s): Blue or Gray • Secondary Color(s): White
Danny Boy is one of the sweetest rabbits in our rescue. He is always wanting to have his head and ears scratched and will come to you for pets. Danny Boy came to our rescue to make room for another rabbit in another rescue that was coming from a kill shelter. The rabbits in Rabbit & Small Animal Rescue are fed 3-5 cups fresh green vegetables daily (endive, escarole, romaine, parsley, dandelion...), quality Oxbow BBT (adults) pellets or Oxbow 15/23 (babies) pellets and unlimited timothy hay. When they are adopted to you, we suggest that their diet stay the same, so you may want to find out which pet stores in your area sells the Oxbow food. If you are interested in adopting from Rabbit & Small Animal Rescue, please go to: www.rasarescue.org and fill out our adoption application and we will contact you within 48 hours. Please fill out completely, as an incomplete application will delay the adoption process. Adoption fee: $90.00
Rabbit & Small Animal Rescue will celebrated their 8th Anniversary on November 7, 2015. In our first year of operation, we have been able to rescue over 200 animals and place 137 furries in permanent, loving homes where they are treated as family members. In our second year of operation we were able to place over 185 furries in permanent homes. For our third and fourth years we did not place as many as in the first two years because of the economy. These animals are alive, happy and healthy thanks to all the great adopters and dedicated volunteers. We are still in need of your donations so we can continuing what we do best. Please click on "How you can help".....we accept PayPal -- this is where you send your tax-deductible donation -- it will only take a minute of your time and will help enable us to continue taking care of these poor homeless creatures.
Rabbit & Small Animal Rescue is happy to announce that we will continue neutering all male guinea pigs (under the age of 3)
September 2015: We adopted out over 900 critters since we began.


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Veterans Benefits Administration Telephone Development and Customer Service Skills June 2012 Compensation Service Training Staff
2 Lesson Objectives List the evidence suitable for telephone development List the telephone development requirements Identify 38 CFR 3.217(b) procedures when conducting a telephone contact Identify procedures for special circumstances that could develop during a telephone contact Identify the procedures to complete VA Form , Report of General Information (Report of Contact) after receiving evidence from a telephone contact Identify the purpose of VA Form , Authorization to Disclose Personal Information to a Third Party Identify the characteristics of VA customers Differentiate the aspects of good communication skills Identify strategies of effective customer service 2
Compensation Service Training Staff 3References 38 CFR 3.159(e) VA's duty to assist claimants in obtaining evidence 38 CFR 3.217(b) Submission of statements or information affecting entitlement to benefits M21-1MR I.1.C.6.c Requirement to Follow Up on Requests for Non-Federal Records by Telephone M21-1MR I.1.C.6.e Using the Telephone, Fax, or to Obtain Evidence From the Claimant M21-1MR, II.2.2 Providing Information to a Third Party M21-1MR II.3 Telephone Interviews M21-1MR, III, iii.1.B.2.c Using , Fax, and Telephone M21-1MR, III.iii.1.B.2.d Documenting Information Received by Telephone M21-1MR, III.iii.1.B.2.e Handling Information Received by Telephone That May Adversely Affect Benefits M21-1MR III.iii.2.I.59.e Contacting the Claimant M21-1MR III.iii.2.K.79.a Contacting State Adjutants General Offices FL Final Rule: Notice and Assistance Requirements and Technical Correction FL 10-49, VA Form Authorization to Disclose Personal Information to a Third Party FL 12-04, Revised Procedures for Telephone Contact and Development 3
Compensation Service Training Staff 4 Suitable Evidence Evidence suitable for telephone development includes: Social Security numbers of dependents Mailing address(es) Direct deposit information Date(s) of birth Reserve or National Guard unit information Information concerning retired, severance, or readjustment pay 4
Compensation Service Training Staff 5 Telephone Development Requirements When following up on requests for non-federal records, you must make one attempt to contact the records custodian by telephone. If the records custodian cannot be reached by telephone on the first attempt: o Make no further attempts to contact the custodian by telephone o Document the attempted telephone call in MAP-D o Send the custodian a follow-up letter to request the records 5
Compensation Service Training Staff 6 Fax Records Ask the custodians of the records to fax the records to the designated RO fax number. (Note: The fax machine must be located in a secure, nonpublic location because the faxed records may contain personally identifiable information.) 6
Compensation Service Training Staff 7 Follow-Up When Service Records are Unavailable 1.Contact the claimant by telephone after the VSCM or designee signs the formal finding of record unavailability. 2.Advise the claimant: o About the lack of a response from the records custodian(s) o Of the requirement that he/she submit any relevant documents in his/her possession o That a decision will be made based on the evidence of record if the requested evidence is not received with ten days from the date notice is given 7
Compensation Service Training Staff 8 Fast Letter Upon expiration of a suspense date, stations should attempt telephone contact with the claimant and/or other providers of information s (e.g., private physicians, Reserve/Guard units, etc.) if doing so might help bring the claim closer to resolution. Successful contacts must be documented on VA Form Unsuccessful attempts must be documented in MAP-D Notes to include the following: o Name of the individual/facility attempting to contact o Specific evidence requested 8
Compensation Service Training Staff 9 Target Your Telephone Development National Guard State Adjutants General Office Military Treatment Facilities o Contact the Release of Information Office at the Military Treatment Facility and obtain the fax number to process requests for military medical records. Clarification needed from Claimant Private Medical Records o Call the contact information to obtain a fax number o Ask what the turn-around time is and set suspense dates accordingly 9
Compensation Service Training Staff 10 Contact Requirements 38 CFR 3.217(b) states the VA employee must: 1.Identify himself/herself as a VA employee who is authorized to receive the information or statement; 2.Verify the identity of the provider as either the beneficiary or his or her fiduciary by obtaining specific information about the beneficiary. This information needs to be verified from the beneficiary's VA records, such as Social Security number (SSN), date of birth, branch of military service, dates of military service, or other information; and 3.Inform the provider that the information or statement will be used for the purpose of calculating benefit amounts. 10
Compensation Service Training Staff 11 Claimant Cannot be Reached If the claimant cannot be reached: 1.Leave contact information in a voic . Example: Good evening, my name is John Doe. I am an employee with the United States Department of Veterans Affairs. I am calling to request additional information needed to process your claim. Please return my call at at your earliest convenience. Thank you. 11
Compensation Service Training Staff 12 Claimant Cannot be Reached If the claimant cannot be reached: 2.Update MAP-D notes. Example: Called claimant to request date of marriage to Jane Doe and her date of birth. Action initiated by John Smith, VSR, , VARO
Compensation Service Training Staff 13 Suitable for or Fax All documents may be accepted by or fax. Exception - Original applications and separation documents intended for proof of service to establish entitlement to benefits 13
Compensation Service Training Staff 14 Adverse Action If a change results in an adverse action and the following is true: Veteran was notified at time of telephone File is documented of notification A pre-determination notice is not required for: Information about income, net worth, dependency, or marriage. Other information, due process is required. 14
Compensation Service Training Staff 15 VA Form Available versions of VA Form : : Report of General Information a: Report of First Notice of Death b: Report of Nursing Home or Assistant Living Information c: Report of Defense Finance & Accounting Service (DFAS) d: Report of Non-Receipt of payment e: Report of Incarceration f: Report of Month of Death 15
Compensation Service Training Staff 16Documentation When using VA Form , the following items must be documented: Specific information provided Date information provided Identity of provider Steps taken to verify identity of provider Verification provider was informed that information would be used for purpose of calculating benefit amounts 16
Compensation Service Training Staff 17 Additional Guidance Proper documentation of contact is required before any action can be taken Provide a copy of the VA Form to the POA 17
Compensation Service Training Staff 18Exercise 18
Compensation Service Training Staff 19Exercise 19
Compensation Service Training Staff 20 VA Form VA Form , Authorization to Disclose Personal Information to a Third Party: Allows the release of specified information to family or other designated persons. Amended to inform incompetent beneficiaries that they cannot submit the form over their own signature. Only one VA Form may be valid at a time. 20
Compensation Service Training Staff 21 Additional Information VA Form : Was amended to inform incompetent beneficiaries that they cannot submit the form over their own signature. Includes information that is limited and unlimited. Allows designated individuals to provide certain information to VA. May only have one designated person or organization and only one form may be valid at a time. 21
Compensation Service Training Staff 22 Procedures Adhere to the following procedures: 1.If the form is not sufficiently complete and legible to authorize access, return it. 2.When the form is complete, update Share with the flash, Third Party Release, and add a statement in MAP-D notes. 3.Go into Virtual VA to determine if there is an e-folder. If there is no e-folder, establish one. 22
Compensation Service Training Staff 23 Revoking the Authorization Upon written receipt: Add MAP-D note Remove the flash in Share Upon receipt by telephone or in-person: Document on a VA Form Upload into Virtual VA Add MAP-D note 23
Compensation Service Training Staff 24 Third-party Authorization If someone claims to have third-party authorization: 1.Verify using Virtual VA. 2.Solicit identity and ask security question. 3.Proceed with standard protocol to identify beneficiary. 4.Review authorization carefully. 5.Note what type of information is permitted for release. 6.Note expiration date of the authorization. 24
Compensation Service Training Staff 25 VA Customer Someone who is seeking a service from our organization 25
Compensation Service Training Staff 26 Types of Customers VA customers : Seek information Want action Are upset 26
Compensation Service Training Staff 27 Customer Needs All customers need to: Feel special Express themselves freely Be right Be treated fairly Feel assured 27
Compensation Service Training Staff 28 Communication Skills VA employees need understand the following aspects of good communication skills : Verbal and non-verbal elements Feedback Barriers 28
Compensation Service Training Staff 29 Verbal and Non-verbal Elements Verbal and non-verbal elements are defined as: Verbal elements are the words that we choose. Non-verbal elements comprise the rest of the message including vocal tone and pitch, emphasis, body language, posture, and facial expressions. 29
Compensation Service Training Staff 30Feedback By using feedback, the VSR: Provides the opportunity to clarify or restate a message. Ensures that clear communication has occurred. 30
Compensation Service Training Staff 31Barriers Common barriers to clear communication include: Physical Language Psychological 31
Compensation Service Training Staff 32 Effective Customer Service VA employees should implement the following strategies: The Seven Cs Six ways to improve listening skills Five ways to improve speaking voice Four methods to acknowledge customer feelings Conversation control 32
Compensation Service Training Staff 33 The Seven Cs Use the Seven Cs to improve customer service: Caring Confident Considerate Committed Creative Controlled Contagious 33
Compensation Service Training Staff 34 Improve Listening Skills Six ways to improve listening skills are: Visualize what youre hearing Do not interrupt the customer Listen for feelings Acknowledge what the other person is saying Ask questions Concentrate 34
Compensation Service Training Staff 35 Improve Speaking Voice Five ways to improve your speaking voice: Speak in low tones Articulate Match the other persons rate of speech Control volume Use voice inflections 35
Compensation Service Training Staff 36 Customers Feelings Four methods in acknowledging a customers feelings: Be empathetic Ask questions Give feedback Summarize the problem or issue 36
Compensation Service Training Staff 37 Conversation Control Be aware of where you are with your call: Get to the question or issue quickly. Answer the question or issue thoroughly. End the call with dignity and courtesy. Remember your manners and be polite. 37
Compensation Service Training Staff 38
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Euro Weakens for First Time in Four Days on ECB Speculationby and
Central-bank policy makers to announce decision on March 10
Euro-dollar implied volatility rises to most since 2015
The euro fell for the first time in four days on speculation the European Central Bank will increase currency-weakening stimulus when it meets this week.
Europe's 19-member shared currency tumbled the most in a week against the dollar as nearly three-quarters of the economists in a Bloomberg survey predict the central bank will expand monthly bond purchases, and all but one see the deposit rate being cut further below zero.
"The pressure is on the euro because of the ECB," said Georgette Boele, a currency strategist at ABN Amro Bank NV in Amsterdam. "We expect a package that will be a more aggressive rate cut and more quantitative easing," which will probably depress the euro to $1.05 against the dollar by the end of June, she said.
The shared currency weakened toward a one-month low versus the dollar as the ECB stimulus projections contrast with Federal Reserve plans to raise interest rates again this year. With negative yields on sovereign debt spreading across Europe, futures prices show nearly a three-quarters likelihood the U.S. central bank will move rates higher, bolstering the allure of dollar-denominated assets.
The euro dropped 0.5 percent to $1.0954 as of 9:31 a.m. New York time. The shared currency weakened 0.7 percent to 124.35 yen. The dollar depreciated 0.2 percent to 113.57 yen.
"You have the ECB policy, which is generally going to be cutting rates, expanding QE, and that tends to weaken the euro," Richard Cochinos, London-based head of Europe Group-of-10 currency strategy at Citigroup Inc., said in an interview on Bloomberg Television. The world's biggest foreign-exchange trader sees the euro "trading below $1.05 and towards parity by year-end, but the path there is neither straight nor direct and the ECB is important."
Market Forces
The euro is the worst-performing major currency versus the dollar after the pound during the past month. Also undermining the euro are investor concern that regional growth slows amid a growing refugee crisis and political uncertainty in Spain and Ireland.
Traders are struggling to shake off the memory of the ECB's Dec. 3 stimulus extension, which underwhelmed markets and sparked the common currency's biggest one-day increase since 2009. Traders' expectations over the next week for price swings in the euro climbed to a three-month high, reaching 16.03 percent, the most since Dec. 2 on a closing basis.
The euro may also be set for declines after it failed to break through its 200-day moving average of $1.1047 on March 4, according to Morgan Stanley.
"Failure to develop a daily closing price above $1.10 today suggests to us that a corrective high has been traded, opening renewed downside potential," Hans Redeker, global head of currency strategy at Morgan Stanley in London, wrote in an e-mailed note.


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A double from Colin Nish at Tannadice yesterday secured fourth spot — and Europa League football — for Hibernian with a deserved victory over a Dundee United side barely recognisable from the one that will run out for the Active Nation Scottish Cup final against Ross County at Hampden Park next weekend.
It was a performance from Hibernian that brought joy back to the face of John Hughes, the manager, after several weeks of criticism from both within and outside the club. "I am absolutely delighted as we have had a fantastic first season playing some great football throughout, " he said. "The


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Home > Product Categories > Batteries and Power > Batteries & Chargers > Battery Pack Replacements > V-BP12-LCD
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LOUI"S MAINTENANCE LTD44 Feedback reviews, 100% positive
we are a reliable professional small company,we provide a high quality of work at competitive price"s,we are fully insured for all the work we take on ,and we are proud of what we do ,no job to small or too big ,we do kitchen & bathrooms,plastering & tiling,wood...
Latest Bathroom Fitting feedback review:
By lara_95 on 29th Jan, 2017
M&S Building12 Feedback reviews, 100% positive
Hi my name is Martin and I am reliable builder with 17 years experience in all aspects of building. I offer wide variety of high quality building services.
Latest Bathroom Fitting feedback review:
By fhoulding on 1st Aug, 2016
Raf & Raf7 Feedback reviews, 100% positive
We are highly professional London focused team that you can depend on when it comes to property improvements.We have been working together for the last 15 years on refurbishment projects.You can count on our knowledge and experience to provide you and your property a high...
Latest Bathroom Fitting feedback review:
By hannah909 on 28th Feb, 2016
Meto Interiors147 Feedback reviews, 100% positive
We are committed to quality, integrity, performance and most important of all – customer satisfaction.
Latest Bathroom Fitting feedback review:
By laura_1b3h on 11th Nov, 2016
LK Home Improvements5 Feedback reviews, 100% positive
We are Home Improvements specialists offering a complete building service. Whether you are looking for a complete refurbishment or a small home improvement, we take care of every detail with dedication and individuality to make your home unique and personalised ensuring an...
Latest Bathroom Fitting feedback review:
By taylor_208 on 24th Sep, 2014
Tried-And-True Developments39 Feedback reviews, 100% positive
We are an established refurbishment company that has provided quality building services in and around London, since 2006. Our developments are proof of our high work ethics and countless satisfied customers.
Latest Bathroom Fitting feedback review:
By sabrina_78 on 21st Feb, 2017
G D Plumbing & Bathroom Contractor56 Feedback reviews, 98% positive
Hi there, I have over 20 years experience in plumbing and bathroom fitting. I am a sole trader who has trade accounts with a number of suppliers so am able to keep the costs down and pass any savings on to the customer. I also give free, no obligation quotes and all work is...
Latest Bathroom Fitting feedback review:
By will_evans_41 on 4th Feb, 2017
LA BUILDING SERVICES28 Feedback reviews, 100% positive
WE have 12 years of general building experience. We take pride in what we do and always strive for the best results to provide an efficient and professional service. £2 million public liability insurance and all work guaranteed for the period of 1 year and comply with...
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By rbraithwaite on 7th May, 2014
MME Contractors6 Feedback reviews, 100% positive
We have been established for over 15 years and have worked on commercial and domestic projects. All our work always complies with building regulations.We are happy to assist with small projects & large scale projects.We pride ourselves on being dedicated to each individual...
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By ebp on 23rd Jul, 2015
R.G Maintenance1 Feedback review, 100% positive
Here at R.G maintenance our first priority is our customers satisfaction. We strive to make sure that all work is carried out in a professional manner and to the highest of standard. Our customers are clearly informed every step of the process with professional and resourced...
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By foresthillresident on 10th Jan, 2017
Top building Ltd.5 Feedback reviews, 100% positive
Top Building was set up in 2009 to combine the skills of various trades specialists who deliver bespoke projects to customers looking for high quality home improvements. We specialise in kitchen/bathroom & home renovations. We have the equipment & experience necessary for...
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By andrew_693 on 13th Aug, 2015
Robert Krysta30 Feedback reviews, 100% positive
I started trading in 2004 as bathroom and kitchen fitter. Since then I've done many projects, those large and really small. All jobs were finished with great attention to details, satisfaction and great appreciation of all my clients.
Latest Bathroom Fitting feedback review:
By rachnich on 3rd Feb, 2017
DB Limited37 Feedback reviews, 100% positive
I started as a k.fitter ,after a few years i become a site manager. Now i am fitting kitchens for my self I also do extensions and conversions as well. So if you want a reliable and professional builder also certified please choose me. Best Regards Stefan
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By ddhar on 5th Jan, 2016
Arthur's Building Service Ltd12 Feedback reviews, 100% positive
We are Arthur's Building Service LTD, based in Carshalton, Surrey.We provide a prompt, professional, experienced and friendly service covering bathrooms, painting, tiling, flooring, plastering & other decorating services for residential and commercial premises in South...
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By travis123 on 17th Feb, 2017
I Love Bathrooms Ltd9 Feedback reviews, 89% positive
Small Family run business been around for a year now but have 20years of experience in the trades combined. All plumbing work undertaken Kitchen refurbs Bathroom refurbs Electrical works Tiling Painting & decorating Floor laying Wetrooms Gas engineer on the team also. Gas...
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By charlottedownham on 17th Feb, 2017
Need a tradesman?
Post a job on MyBuilder to find a quality, local tradesperson.
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1. Post a job
First, create a job listing for your bathroom fitting project. It's quick, easy and free - the first step to finding recommended bathroom fitters in Wallington.
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3. Leave feedback
After your project is successfully completed, you can leave a review for your bathroom fitters. This review helps you and future MyBuilder users.
What our customers say
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Tradesmen in Wallington
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Sports CostumesMORE FROM THIS CATEGORY:
Football CostumesMORE FROM THIS CATEGORY:
NFL Costumes
NFL Costumes
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Adult NFL Denver Broncos Fan Face Mask£13.99
Adult NFL Dallas Cowboys Fan Face Mask£13.99
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Imagine the smell of the fresh field grass, the roar of the massive crowd, and that incredible feeling one gets from catching the game winning touchdown with sconds to spare. If you can relate to these kinds of daydreams, (we've all been there at least once) there's no doubt about it... you're a football fanatic. You've come to the right place! If you want to become the star player on your favorite NFL team this Halloween, you're sure to find their uniform and helmet right here in our huge selection of teams. We carry football costumes for adults and kids, and even dogs! Even the family pet can get in on the game day action. Don't go another minute without displaying your team pride loud and clear with a licensed NFL costume! Hut, hut... hike!


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Seasons View Hotel, Kuantan
- Free WiFi and free parking
Main amenities
- 61 guestrooms
- Restaurant
- Breakfast available
- 24-hour front desk
- Air conditioning
- Daily housekeeping
- Front desk safe
- Meeting rooms
- Concierge services
- Free newspapers in the lobby
- Porter/bellhop
For families
- Refrigerator
- Connecting/adjoining rooms available
- Private bathroom
- Premium TV channels
- Television
- Free toiletries
What's around
- In Kuantan
- Heroes Museum (0.3 mi / 0.5 km)
- Masjid Negeri (0.4 mi / 0.7 km)
- Darulmakmur Stadium (0.9 mi / 1.5 km)
- Wan Fo Tien Temple (0.9 mi / 1.5 km)
- Gelora Park (2.3 mi / 3.6 km)
I left my thing behind and they help us to send it back to us by posting.thx and good…
Bath cubicle too small in size. Rest wise it's pretty good
Seasons View Hotel, Kuantanfrom £19
- Deluxe Family Suite
- Standard Room
- Standard Twin Room
- Standard Triple
- Standard Family
- Standard Deluxe
- Executive Suite, Connecting Rooms (Family)
- Deluxe Room, Connecting Rooms (Family)
- Superior Room (Family)
- Executive Family Suite
- Standard Room (Family)
- Standard Triple Room
More great choices
At a glance
Key facts
Hotel size
- This hotel has 61 rooms
- This hotel is arranged over 4 floors
- Check-in time starts at 2 PM
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking (limited)
Nearby Three Star Kuantan hotels
In the hotel
- Buffet breakfast daily (surcharge)
- Restaurant
- Room service (during limited hours)
- Meeting rooms 3
- 24-hour front desk
- Concierge services
- Free newspapers in lobby
- Porter/bellhop
- Safe-deposit box at front desk
- Accessible bathroom
In the room
- Air conditioning
- Iron/ironing board (on request)
- Private bathroom
- Shower only
- Free toiletries
- Premium TV channels
- Free newspaper
- Free WiFi
- Phone
- Refrigerator
- Free bottled water
- Daily housekeeping
- Connecting/adjoining rooms available
Top Kuantan hotels
Recently reviewed hotels in Kuantan
- The Legend Resort CheratingFrom
"Although the hotel is not new, the facilities are generally well maintained. In front of a nice and quite beach, nice breakfast, big rooms and big swimming pools."Aug 15, 2016
- Sun Inns Rest House KuantanFrom
"Very comfortable n save money."Jan 18, 2016
- Samsuria Beach Resort & ResidenceFrom
"A very good experience having spent 2 nights."Dec 16, 2015
- Holiday Villa Beach Resort & Spa CheratingFrom
"Pleasant staff - very helpful. Rooms need updating."Oct 20, 2015
Nearby hotels
Also popular with travellers from the UK
Special features
DiningRitz Grill – This restaurant specialises in international cuisine and serves breakfast, lunch and dinner. Open daily.
Seasons View Hotel, Kuantan's small print
Also known as
- Hotel Seasons View Kuantan
- Hotel Seasons View
- Seasons View Kuantan
- Seasons View Hotel Kuantan
- Seasons View Hotel Kuantan
The property has connecting/adjoining rooms. These are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Optional extras
Buffet breakfast is offered for an extra charge of MYR 12 for adults and MYR 7 for children (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Good 3.5 /5 from 22 reviews
-Clean & spaces bathroom. -Easy to drive & exclusive parking
Ask for twin bed but gave us king size bed. If no twin bed should not confirm it and ask for payment.
Is the description of this hotel not correct? Tell us


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Hotels in Huber Heights
Hotel reservation
United States
Huber Heights
Hotel rooms in Huber Heights
There are not so many hotel rooms in Huber Heights, just 9, still everyone can find an offer to suit his choice. The most common offers in this city are 3 и 4 stars, they count 4 out of 9, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the north of Huber Heights, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Huber Heights. The most populated with hotels district of Huber Heights is the north, 100% of cheap hotel rooms are concentrated here. Huber Heights is an ideal place for couple and family, such travellers rate hotels there 7.2 out of 10 on average. Apart from all these, hotels in Huber Heights offer their customers laundry service, 24 hours front desk service, parking and business centre. The staff of the most hotels is multilingual: it speaks english. The most appreciated amenities in Huber Heights hotels are value for money and cleanliness. According to the visitors reviews, hotels in Huber Heights has best value for money, great location and great wellness & sports facilities. Take a look at our selection of the cheap hotel rooms in Huber Heights to make a well-informed choice for your reservation!
hotel collections
Top-4 hotels in the center of Huber Heights
average rating
It is not a surprise that many guests arriving to Huber Heights pay great attention to the location of their hotel. In order to save your time, we have prepared a collection of the hotels in the center of this city.
Show hotels
Huber Heights hotels with swimming pool
average rating
If you like healthy lifestyle, it is very important to train every morning. One of the greatest ways to do it is to swim in the pool! Here is a collection of the cheap hotels with swimming pool in Huber Heights.
Show hotels
Huber Heights hotels with restaurants
average rating
Do you like to eat? We, too :) So we collected hotels Huber Heights with a restaurant in the same place.
Show hotels
Pets-friendly hotels in Huber Heights
average rating
"We are responsible for those who tamed" - said Antoine de Saint-Exupery.
Show hotels
All hotel collections in Huber Heights
Best hotels in Huber Heights
Hotels in Huber Heights are spread around the city within the distance of 5.9 kilometers. Those who are keen on antique should definitely fall in love with
Baymont Inn and Suites Huber Heights Dayton
, the oldest hotel of Huber Heights, constructed in 1988. This hotel is located 3.3 km away from the city center. The most popular accommodations in Huber Heights is
Days Inn Dayton- Huber Heights
located in a 3.2 kilometers from the city center.
The best hotels are here and now. Try them!
All cities in United States


text:
SQL Server User Group
Abstract: As companies start to embrace cloud based technologies, IT organizations will need to understand the available solution capabilities. Microsoft Azure is full of tools that improve data movement, storage, analysis and consumption. Some traditional on-premise concepts still apply and others do not. In this session, we will look at real world customer examples embracing Azure and provide insights into how organizations can start planning their move to the cloud.
About Dave: Dave DuVarney is President and Co-Founder of Talavant. Dave has delivered numerous business intelligence projects in both a technical and functional leadership role. Dave's latest technical focus has been on leveraging Microsoft Azure to support Business Intelligence need. Along with technical delivery, Dave has assisted clients in establishing Data Warehousing and Business Intelligence initiatives. This includes working with executive stakeholders to define objectives, assisting in the identification of team roles and implementing development best practices using Agile Scrum. Dave is currently training for his 4th marathon and hopes to not blow out a hip or calf muscle along the way.
Abstract: You are invited to be a participant on the SQL Server DBA Quiz Show; this interactive session will test your knowledge of SQL Server. We will be using an online tool to allow you to submit your answers to questions via a mobile device or laptop. If you have ever played trivia in a bar or restaurant you'll be familiar with the setup for this.
This session promises to be fast paced and fun and hopefully you will even learn something. This session will also be of value to people who need to interview or be interviewed for SQL Server positions as the questions may be the type of things you might hear in an interview.
About Eric: Eric is the SQL Server Architect for Boston Scientific, a self-proclaimed Level 70 Database Slayer, he enjoys development, performance tuning, and troubleshooting SQL Server.


text:
Revolver Metal T-Shirt
Limited edition Revolver t-shirt by renowned heavy metal artist Seldon Hunt (Isis, Neurosis, and Jesu). This one-of-kind t-shirt is 100% cotton black, with the logo printed in special metallic ink. Amuse your friends, scare your parents. I want your skull…I need your skull.
Currently the only size available is XL (24" Wide x 30" Tall)
Buy one today! Limited Quantities Available!!!!
Please note that this item may take up to two weeks to ship from our vendor. We apologize for the delay.


text:
search for a card
Result of the search for the collectible card:
|Low: 0.20€
|Avg: 2.61€
|[View all]
The following 9 users match with the requested search. Click on their names to contact them.
For some advice on how to trade cards click here.
- antares LV92 (United States-California)
- sl1ferm4ster LV135 (United States-Virginia)
- solid_snake LV25 (Spain-Valencia)
- mymaster LV29 (United States-Ohio)
- bamfreaper69 LV34 (United States-Rhode Island)
- kaibacorp01 LV20 (Mexico-Guanajuato)
- luisjoel LV11 (Puerto Rico)
- xindyh LV9 (United States-Ohio)
- jakellord LV9 (United States-New Mexico)
When you register you will be able to search for all your cards in one go, and we will send you any new results of the search every day by email.


text:
link: "//www.loc.gov/pictures/item/fsa1997019034/PP/",
url :"//cdn.loc.gov/service/pnp/fsa/8a19000/8a19100/8a19108_150px.jpg",
alt:'Image from Prints and Photographs Online Catalog -- The Library of Congress'
[Untitled photo, possibly related to: [New York, New York. 61st Street between 1st and 3rd Avenues]]
- Digital ID: (digital file from original neg.) fsa 8a19108 http://hdl.loc.gov/loc.pnp/fsa.8a19108
- Reproduction Number: LC-USF3301-006717-M2 (b&w film dup. neg.) LC-DIG-fsa-8a19108 (digital file from original neg.)
- Repository: Library of Congress Prints and Photographs Division Washington, DC 20540 USA http://hdl.loc.gov/loc.pnp/pp.print
About This Item JPEG (45kb) | JPEG (239kb) | TIFF (12.6mb) | TIFF (25.1mb)


text:
Separate names with a comma.
Discussion in 'Money Talk$' started by SaggyWoman, Apr 25, 2010.
How has your church done on meeting their budget this year?
We were short on our budget but our spending had been cut to make sure we never went over budget. This year the salaries were frozen for another year and we're cutting back a bit on some "extras". Giving is still down so we'll see what goes on.
We didn't meet our budget but some of that was already discretionary, so we just didn't spend it.
Wages were frozen again this year. We cut our budget to be in line with what was given last year.
This year doesn't look much better. But God is good, we still are able to have an associate pastor on staff. We cut our secretary's salary (who had retired) and are using volunteer which does cause some difficulties but we have not had to cut any ministry line item. :godisgood:
We've cut expences.
We've put off maintenence.
We've reduced funding for new missions projects
We've reduced salaries and cut staff in order to cover skyrocketing medical insurance increases.
The people wanted change - they're getting it :tear:
Increased taxation, decreasing employment, greater public needs.
On the up side we've seen an increase new people coming to church.
We've also seen an increase in new professions of faith. :applause:
No one got a raise this year but the money is always there for necessities.
Our general fund giving is up about 30%. All of our bills are paid. Last year the church raised the funds to purchase 6.1 acres of land. This year we've raised most of the funds to build a 40x60 foot pavilion, put in a road, electric and septic system. The land and property development are costs above and beyond the general giving.


text: Venditore: suzi_all_that_glitters (638) 99.5%, Luogo in cui si trova l'oggetto: Sunbury, Spedizione verso: GB e molti altri paes, Numero oggetto: 332035791857 3 lovely pairs of socks for the warmer weather, each depicting Waybuloo Characters, those of Lau Lau, Yojojo and De Li. These are brand new with original labels attached stating the Original retail price of £6.00. Stock is of a limited quantity so grab yourself a great bargain while they last. Available in the following shoe size: 6-8.5 age 2-4 years shoe size 9-12 age 4-7 years Would make a great gift idea for children.Thank you for LookingComes from and pet and smoke free home I offer combined postage and will refund excess postage paid if items are pre-paid. Be sure to add me to your favourites list!Check out my other items! Brand: Ex chain store, Style: Ankle Socks, Main Colour: Pink, Material: Cotton rich, Pattern: Waybuloo character