text:
AIIMS Delhi Staff Nurse Result 2016
Be ready to download your AIIMS Delhi staff nurse Result 2016 because hopefully the All India Institute of Medical Science has clear the exact date of declaration of AIIMS Delhi staff nurse Result with its Merit List and with Interview Date on its official website.
The scorecard will be declared on 2nd march, if you one of them who applied for that exam which the All India Institute of Medical Science has already clear the notice for recruitment examination to filling up 692 vacant vacancies for the post of Staff Nurse, then you will soon able to download their your scorecard.
The written exam was successfully conducted by the department on 15th February in many centers and now it's time to take the interview in the month of April 2016, only for qualify candidates after the declarations of AIIMS Delhi staff nurse Result 2016 which is soon published by the organization through its main portal.
Organization Name: All India Institute of Medical Science of Delhi
Pattern: Recruitment Examination
Exam: Staff Nurse
Date of Examination: 15 February 2016
No of Post: 692 Vacancies Available
Issues Date: 2nd March
Interview Date: April 2016 (Estimated)
AIIMS Delhi Staff Nurse Merit List & Interview Date
As we all know after giving the examination all candidates are very keenly to see their performance with the help of AIIMS Delhi staff nurse Merit List. The scorecard with its merit list will be available on its official website in the month of March.
The candidates must check their scorecard so they know that they will qualify or not. If you clear in this exam so you must start to prepare for an interview because the departments will b conduct the interview. The final selection is based on the interview.
Instructions to download AIIMS Delhi Staff Nurse Result 2016
- First of all, they have to select the official website.
- Then the applicants have to find the result status and click on it.
- Now they need to input some details like roll no and password and submit it.
- Once you submit the details the scorecard will be visible on the screen.
- Check your scorecard that is ok or not if it is ok then take hard copy and keep it safe for future use.
Important link:
Download scorecard forms official website


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School days
Ch 1 new student.
Roy Mustang, senior and star athlete at Central Academy for the Gifted strolled down the hall, casually talking with his best friend Hughes.
"She's getting more beautiful by the day!" Hughes was saying, though Roy was only half listening, he was watching a young looking boy talking to coach Armstrong.
The boy had long gold tied in a loose braid, large, surprisingly, mature gold eyes and looked good in the school uniform which was white with gold that hardly rivaled that of the boy's hair. The boy was cute, Roy wonder if he was his type.
Little did most know, Roy was bisexual, and was glad to see a new student for a change. Roy was the most well know students and knew everyone. He made a mental note to talk to the blonde.
Edward walked into his first period, ten minutes late. He glanced at the teacher who gave him a stern look.
"I'm sorry sir," He muttered, bowing his head a little.
"You must be the new student," The teacher said. "Mustang, raise your hand, You'll be sitting next to him, Mr.….?"
"Edward Elric" Edward stated and looked at the boy who raised his hand, taking the seat next to him. He glanced at the boy, or young man rather. 'Mustang' as the teacher called him was quite handsome. He had short black hair that was silk like, and fell into his cool, yet soft equally black eyes. He had a strong shaped jaw and broad shoulders yet had an air, calm and friendly look about him.
Mustang caught the blonde's smiling softly at him. He tossed a small note to him and the blonde read it.
Hey, meet me outside after class and I'll show you around
Edward blinked at the letter and looked at Mustang who winked. The blonde's soft cheeks tingled pink and turned his attention to the teacher.
I know, short chapter, its 1:13! Next one will be longer, I promise

subset: commoncrawl


text:
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Situated on the shore of Lago Maggiore in Brissago, Sunstar Boutique Hotel Villa Caesar offers panoramic lake and mountain views, outdoor and indoor pools, a sauna and massage room, and a restaurant...
"Lovely physicality in a perfect location."
278 reviews
At the edge of Lake Maggiore, Hotel Garni Rivabella au Lac offers simply-furnished accommodations with free Wi-Fi. It has direct lake access, a secluded yard and shaded terrace.
"Visited from Canada with my 20 year old daughter. …rconditioned but fans are available at reception."
373 reviews
Garni Morettina is a family-run hotel, located in the centre of Brissago, a 2-minute walk away from Lake Maggiore. Every room has a terrace or a balcony with lake view.
"Very friendly welcoming owners"
124 reviews
All rooms at Yachtsport Resort Lago Maggiore in Brissago offer views over Lake Maggiore. Guests have access to a private beach with a palm garden, and free WiFi is available.
"A top notch hotel with excellent staff and a wonderful location."
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Located just 500 metres from the waterfront at Lake Maggiore, Parkhotel Brenscino features a heated outdoor pool, a large terrace with panoramic views and a 38,000 m² botanical garden.
"spectacular view of lake & mountains"
Very Good
121 reviews
Surrounded by a lush garden a short walk from the centre of Brissago, Hotel Primavera offers panoramic views over Lake Maggiore and the Brissago Islands. All rooms have lake views.
"Fantastic views, friendly hosts. Rooms are large a…- fresh towels on a daily basis. Great breakfast."
22 reviews
Casa Cucarda offers accommodation just off the lakefront promenade in Brissago. Each room here has a well equipped kitchen, a living room and views of Lake Maggiore.
"Location, Location, Location. Loved the lake from …f the property. Very quite this time of the year."
19 reviews
Surrounded by a large garden with a heated outdoor pool in summer, Casa Ghiggi overlooks Lake Maggiore and the surrounding mountains.
67 reviews
Peacefully situated a 5-minute walk from the centre of Brissago and overlooking the Lake Maggiore, the family-run Venus Garden Pension is surrounded by a picturesque garden with a furnished terrace...
"the view. the location. the flexibility and friendliness."
Casa Maria Cristina Brissago is a self-catering accommodation located in Brissago, is about 40 mq on the third floor with a nice view of the lake, the mountains and the countryside.
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text:
Lebanon to Ban Colored Chicks16 Nisan 5775 – April 4, 2015
It's very common to buy colored chicks as part of the Easter holiday celebration in Lebanon.
To make the colored birds, vendors throw baby chicks in dye and color them. They're then sold by street vendors.
Lebanese animal rights activists have been complaining for years about the practice, as the dyes are often poisonous, the conditions the birds are kept in are horrendous, and more often than not the chicks are mistreated, killed or abandoned by their owners once the dye wears off or the chicken begins to grow up.
Beirut's governor has forbidden the sale of the colored chicks, and the Lebanese government is working to make it illegal in Lebanon, according to a report in the Lebanon Daily Star.


text:
Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
My uncle recently passed away. My aunt was named executor of his will, and she has probated the will under an independent administration, through the filing of an inventory. From what I understand, no other filings are typically needed. The will left everything to my aunt, including their home (both are named in the deed); also, my uncle had an undivided one-third interest in some unimproved real estate (hunting land), in his name. The will is probated in Texas, all property is in Texas. My aunt would obviously like to update the deeds. Is this something we should hire an attorney for? (Presumably we'd need two attorneys -- the hunting land is in a faraway county.) If so, what documentation will we need to give the attorney? If not, is there a good resource that would help us? And finally, should we close the independent administration once the real estate issues are settled?
Yes, the executor can issue an executor's deed to complete the change in the title. One attorney should be able to handle it, as you can file this by mailing. Whether or not to close the IA is a choice. Many attorneys choose to leave them open, in case of a subsequently discovered asset.
Post a free question on our public forum.Ask a Question
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text:
I'm a noob. How do I uninstall chrome? I am having problems downloading some PDF files and I see in other posts that Chrome can be a problem. What browser do you recommend and where can I get it?
Printable View
I'm a noob. How do I uninstall chrome? I am having problems downloading some PDF files and I see in other posts that Chrome can be a problem. What browser do you recommend and where can I get it?
uninstalling system app will cause issues. far more issue than having problem downloading pdf.
and btw, pdf files download fine for me on chrome.
other browsers, dolphin or firefox.
You can't uninstall it (unless you're rooted, I suppose) because it's built into the Android operating system. You can disable it by going into Settings > Apps > All > Chrome, and pressing Disable, though I wouldn't recommend that.
I've not had a problem downloading pdf's and opening them in 3rd party pdf readers (I use Adobe Acrobat Reader). However, it is true that the mobile version of Chrome cannot open a pdf from within the browser. I don't know of other browsers that can do this, as I've not had a need for that.
Just hold it down until it flashes, then drag it to the button at the top of the display.
It disappears into the app file, not uninstalled or disabled... just gone from your app screen and you then go get a different browser in the GPlay store...
Sooooo... is it okay to uninstall Chrome in favor of Chrome-Beta to free up about 40MB (have root)?
Sent from my Nexus 4 using Android Central Forums
When I try uninstalling chrome it will not uninstall. I do not see the install/uninstall options, all I see are Update and Install. I'm trying to permanently uninstall because for the last three days I have had to uninstall Google Music Downloader because it launches itself all the time. It also doesn't allow me to uninstall. In my opinion, Google IS a virus. I'll never install anothe google app, that's for sure. Is there a way of permanently deleting these apps? I've got a Samsung Galaxy Note III.
i have most of the gapps disabled. only gmail, play books, and keep do i have going.
How do I root my phone. And will that help me get back on the internet because Google chrome is encrypted obsolete cipher suite


text:
The 2012 youth spring turkey season will begin on private lands and authorized state and federal lands on Thursday, March 8th. This special season, which is available to hunters ages 15 and under, coincides with spring break for many of Mississippi's school systems. This opportunity is an excellent chance to introduce young hunters to the thrill of pursuing springtime gobblers.
Youth hunters ages 15 and under are not required to possess a hunting license. However, before hunting alone, youth between the ages of 12 and 15 must have a certificate documenting satisfactory completion of a hunter education course approved by the MDWFP. Youth 15 years of age and under may hunt without having a certificate of hunter education if they are in the presence and under the direct supervision of a Mississippi licensed or exempt hunter that is at least 21 years of age.
Bag limits for youth during the spring turkey season are 1 gobbler per day, 3 per spring season. The regulation that limits turkey harvest to adult gobblers or gobblers with at least a 6" beard does not apply to hunters 15 years of age and under.
[1] http://www.addtoany.com/share_save?linkurl=http%3A%2F%2Fwww.biggamehunt.net%2Fnews%2Fyouth-turkey-season-offers-excitement-mississippis-young-hunters&linkname=Youth%20Turkey%20Season%20Offers%20Excitement%20for%20Mississippi%26%23039%3Bs%20Young%20Hunters%20%20%7C%20Big%20Game%20Hunt
[2] http://www.biggamehunt.net/sections/Mississippi
[3] http://www.biggamehunt.net/sections/Turkey
[4] http://www.biggamehunt.net/sections/Youth_Hunting


text:
Yamaha DTX522K Electronic Drum Kit
Yamaha DTX522K Electronic Drum Kit
The Yamaha DTX522K Electronic Drum Set has a professional feel, sound and feature set to satisfy even the most demanding drummer! The DTX-PAD snare pad has a stick feel and response very similar to an acoustic snare and allows you to play the head, open rimshot, and closed rimshot voices in each of the three zones. The DTX522K also features 3-zone operation for the ride, crash and hi-hat.
Yamaha also gives this drum kit the updated DTX502 module which goes far beyond its predecessor in both sound quality and quantity! With the advanced practice tools and easy song recorder you will be getting better all the time. The USB port allows control over VSTi software and lets you import custom wave files into the DTX522K electric drumset.
Yamaha DTX522K Electronic Drum Set Features:
DTX502 module with over 250 more sounds than it predecessor
DTX-PAD snare pad has a stick feel and response very similar to an acoustic snare
Cymbal muting, natural cymbal swells, and smoother snare drumrolls are possible
3-Zone hi-hat technology
3-Zone cymbals with choke feature for great realism
Drum training functions are included to challenge you no matter your current skill level
DTX502 module can be expanded with four additional pads or triggers
Your original WAVE can be imported: Up to 12sec (sampling rate 44.1kHz, 16bit, mono), 20 files
Kick drum pedal not included
Powerful DTX502 Drum Trigger Module
The DTX502 module from Yamaha has almost twice the wave ROM and over 250 more sounds than its predecessor and features new drum and cymbal samples from top VST developers that have been optimized for DTX. Also voices inherited from our other DTX modules have been updated for improved playability and sound.
Advanced Technology Under The Hood
Yamaha used proprietary laser technology to analyze drum strokes and was able to precisely tune the trigger settings on the DTX522K for a more natural feel. Professional features like cymbal muting, natural cymbal swells, and smoother snare drumrolls which were normally only included on higher end drums are also possible! 3-Zone hi-hat technology when using the PCY100 as a hi-hat pad.
3-Zone Cymbals with Choke Feature Deliver Realistic Expression!
The DTX522K drumset also features Yamaha's professional 3-zone cymbal pads, which can express a different sound in each of the cup, bow and edge zones. These cymbals have a good stick feel and low acoustic noise, which is essential for electronic drums when used for private practice. In addition to a very natural swaying motion, they also have the choke function 360-degrees around the edge. You can even mute the cymbal before striking it - a DTX exclusive feature!
Updated Practice Functions With Scoring
New drum training functions are included to challenge you no matter your current skill level every time you practice. Working with these tools will help you improve the most important skills for drumming from rhythmic timing to pad accuracy and endurance. The system will even generate a score so you can track your progress as you improve.
New Design Offers Versatile Trigger and Upgrade Options
The DTX502 module is perfect for use in a hybrid kit with your acoustic drum hardware, and can be expanded with four additional pads or triggers. Pad upgrades let you build your dream kit as your skills improve. USB connectivity lets you connect to a PC.
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text:
Zephaniah 2Contemporary English Version (CEV)
Turn to the Lord
2 You disgraceful nation,
Judgment on Philistia
4 Gaza and Ashkelon
6 Your seacoast will be changed
Judgment on Moab and Ammon
8 The Lord All-Powerful,
Judgment on Ethiopia
12 People of Ethiopia,[f]
Judgment on Assyria
13 The Lord will reach to the north
Contemporary English Version (CEV)
Copyright © 1995 by American Bible Society
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text:
Singita Ebony Lodge
Situated in the heart of the game rich Sabi Sand Private Reserve in South Africa, Singita Ebony prides itself on providing guests privacy and luxury. Found on the banks of the Sand River the exclusive property is in prime 'big cat country'. Ebony is the original Singita lodge and boasts interiors that are spacious and inviting, with a warm rich colour pallet.
The lodge possesses 12 elegant suites. There are 10 one bedroom suites and 2 two bedroom family suites, all of which boast a private plunge pool. Each air-conditioned luxury suite contains a spacious bathroom, indoor and outdoor shower, an expansive living area with fireplace, mini bar and fridge, private wooden leisure deck and private plunge pool.
The lodge offers guests a wide variety of facilities, including the cooling swimming pool in the main lodge area and relaxing spa and gym facilities. For quiet time, the library and wine cellar provide solace with the library also affording a connection to the outside world, housing computers and direct internet connection. The lodge does offer WiFi, however it can be slow due to the property's remote location. Children of all ages are welcome at the lodge and baby-sitting services are available.
How to get to Singita Ebony Lodge
Approximately 5.5 hour's drive from Johannesburg, 1 hour from Hazyview and 1.45 min from the Kruger Mpumalanga Airport. Federal Air offers a daily return flight direct to Singita Sabi Sand from Johannesburg Airport and Kruger Mpumalanga Airport. Private air charters are available on request.
Activities at Singita Ebony Lodge
Early morning game drives; afternoon into spot lit evening game drives in open Land Rovers; guided bush walks; seasonal fishing and community tours.
Singita Ebony Lodge Photo Gallery
Why choose Mahlatini
- 100% Financial Protection
- Specialist Knowledge
- Personal Service
- 100% Tailor-made
Nearby Accommodation
Interested in other Sabi Sands accommodation? Here's a list of other places to stay near Singita Ebony Lodge
- Chitwa Chitwa Private Game Lodge
- Kirkman's Kamp
- Lion Sands Ivory Lodge
- Simbambili Game Lodge
- Singita Boulders Lodge
- Arathusa Safari Lodge
- Dulini Leadwood Lodge
- Dulini Lodge
- Dulini River Lodge
- Leopard Hills Private Game Reserve
- Lion Sands River Lodge
- Rattrays on Mala Mala
- Savanna Lodge
- Londolozi Tree Camp
- Londolozi Varty Camp
- Nottens Bush Camp
Singita Ebony Lodge Reviews
Read what our previous clients thought of Singita Ebony LodgeClient Score: 5 out of 5 based on 1 reviews 5 View more reviews
Mr Matthew Batham5
Again, Ebony was a similar standard and level as Sweni, but was a great contrast and felt really different. The safari here was more accessible (we saw more) but didn't have quite as wild a feel as Sweni. A great contrast.Read full trip review
Selected Itineraries
Our favorite itineraries that visit Singita Ebony LodgeAll South Africa Itineraries
Western Cape, Kruger and Dubai holiday
- Days
- 16
- Cost Per Person
- From $6,300 (Includes international flights from JFK)
- Countries
South Africa
United Arab Emirates
- Locations
- Cape Town, Winelands, Sabi Sands, Dubai
Luxury Kruger and Mozambique Safari and Beach Holiday
- Days
- 15
- Cost Per Person
- From $7,730 (Includes international flights from JFK)
- Countries
South Africa
- Locations
- Bazaruto Archipelago, Sabi Sands, Ngala Private Game Reserve


text:
In the life insurance world, a small number of producers make it to the top.
We will help you get there and stay there.
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AgencyONE helps you look at a scenario and figure out different ways you may want to do or not do it – but you are vetting it and feeling confident about it.
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text:
|Reviews for One Round
| Guest chapter 1 . 1/24/2013
HOT! HOT! HOT! I'm only sorry I never had a chance to read this brilliant work before.
| dashinginconverse chapter 1 . 1/3/2012
I remember reading this a while back and just found it to review. I think you did a great job writing this and I love how you've written these two. I would love to read another CenaPunk pair from you. Great job!
| Miss Toughie chapter 1 . 10/29/2011
Very well written with a great premise. Seems like it could be a great set-up for a sequel.
| littleredkels chapter 1 . 9/28/2011
... Yes. Just yes. that is all.
| skylarkfreedom chapter 1 . 9/5/2011
I love this story! I'm oddly obsessed with this pairing, and you've written them in a way that totally fits with the personalities I have for them in my head, especially with how they've been interacting lately!
My favorite line is the: "An imperfection in something considered otherwise flawless was his favourite part of everyone and everything." That strikes me as so very "Punk".
I'd love to hear more from you with regard to this pairing!
| Xenarocks99 chapter 1 . 8/21/2011
That was hotter than hot
| IsidoraAngst chapter 1 . 3/20/2011
I loved the story. There should be a part two. I demand a part two. I want them to be a happy couple. This coupling is growing on me.
| gamesgrl5887 chapter 1 . 2/20/2011
That was sooo good. I wish you would write a sequel!
| takers dark lover chapter 1 . 2/17/2011
This was really good I enjoyed it very much.
| The Scurvied One chapter 1 . 2/14/2011
holy cow batman! im not gonna lie, after reading some of the worst fiction every, i happen to stumble onto this, and damn. that was really good. you truly do have a way with words!
| xAracnaex chapter 1 . 1/29/2011
So I was going to message you and tell you how much I've enjoyed reading all of your writing but it won't let me so I'll leave a review :) This story, along with Tangerine Dream, Helping Hands, Get Down, and Happy Birthday are my absolute favorites, but I love everything you have posted. I hope you post another soon and I can't wait to see what happens with it. Thanks for a while of entertainment and please keep writing.
| GrandpasGuitars chapter 1 . 1/27/2011
Holy totally long and totally worth it read.
I love your characterization, as always. As far as Punk goes, I think you write him with a fair amount of humanity and a lion's share of douchebaggery, and I'd have it no other way. And no one gets Cena like you get Cena.
I also enjoy how you didn't make Punk any less (I want to say dominant?) than he is, just because he's smaller than Cena. He still had control because of his more forceful personality, and I think that's something people rarely remember. Personality.
And yes, it was hot, but damn were the little story details incredible too. Like Cena's scar and such.
Great fic!
| Glamagirl chapter 1 . 1/22/2011
I have to start by saying this: I hate Cena. I do, really! But damn I saw this story and it had Punk and I said to myself: Self, go and read it, there's no damage in that...
And oh boy! Now I'm so glad that I did because it's a great piece. I love the way you wrote both characters (Yup, Cena too), I can see them both acting exactly like that. Especially with Punk, all his lines here were pheomenal lol. I'm telling yo, a few minutes into reading it I was hooked!
A dominting Punk is always lovely and I even liked John here, the love/hate relationship plot is one that I will always love.
Great story that will go straight to my favorites ;)
| fangirlxfantasies chapter 1 . 1/22/2011
Loved it! That was so expertly written my self esteem just shot down 2 points! :P lol. your portrayal of punk was so realistic too. and all the little one liners from him were hilarious. And thank you for not making him the bitch, dominating 'wont take your shit' punk is my favorite kind. (oh and the quip at the end about jeff made me lol)
great fic! is it too much to ask for a sequel? :P
| LegacyChick chapter 1 . 1/22/2011
Hmmm... Punk and Cena... I dunno what to think of that pairing, but the story itself was great (as usual). Love/Hate relationship is bound to happen there.
I don't think the story's really 'smut' since your focus is on the emotions and feelings cursing through them the whole time.
I actually quite enjoyed reading it, which I've never thought would happen when reading the pairing :)


text:
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2
Li H.,Karolinska Institutet |
Lakshmikanth T.,Karolinska Institutet |
Garofalo C.,University of Catanzaro |
Enge M.,Karolinska Institutet |
And 7 more authors.
Cell Cycle | Year: 2011
Escape of tumor cells from cell-intrinsic barrier mediated by tumor suppressors and cell-extrinsic barrier mediated by the immune system is crucial for tumorigenesis. Growing evidence suggests that reactivation of tumor suppressor function or restoration of anticancer immunity are promising strategies for anticancer therapy due to their high potential to combat cancer. p53, a key tumor suppressor, represses tumorigenesis by eliciting growth arrest, apoptosis or senescence in cancer cells. Here, we unravel that, apart from these cell-autonomous effects, p53 activates the innate immune response against cancer cells. Our results show that pharmacological reactivation of p53 can stimulate the expression of ULPB2, a ligand for NK cell activating receptor NKG2D in human tumor cells of different origin, which enhance the susceptibility of tumor cells to NK cell-mediated killing. The molecular mechanism controlling ULPB2 expression by p53 is neither ATM/ ATR- nor caspase-dependent. Using several approaches, we identified p53 as a direct transcriptional regulator of ULBP2 and found a p53 response element within ULBP2 gene, which confers the p53 regulation. Furthermore, we demonstrated that demethylation of p53-binding region within ULBP2 gene was required for p53-dependent induction of ULPB2, which can be achieved via repression of DNA methyltransferases (DNMTs) by p53. This molecular evidence for the direct control of immunosurveillance by p53 links tumor suppressor activation to innate immune stimuli and provides a possibility to integrate cell-extrinsic and -intrinsic defenses against tumorigenesis by pharmacological activation of p53, which may increase the probability to achieve a durable therapeutic success. © 2011 Landes Bioscience. Source
DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells
Degl'Innocenti D.,Molecular Mechasnisms Unit |
Romeo P.,Molecular Mechasnisms Unit |
Tarantino E.,Fondazione Istituto Nazionale Dei Tumori |
Sensi M.,Human Tumors Immunobiology Unit |
And 9 more authors.
Endocrine-Related Cancer | Year: 2013
Thyroid carcinomas derived from follicular cells comprise papillary thyroid carcinoma (PTC), follicular thyroid carcinoma, poorly differentiated thyroid carcinoma (PDTC) and undifferentiated anaplastic thyroid carcinoma (ATC). PTC, the most frequent thyroid carcinoma histotype, is associated with gene rearrangements that generate RET/PTC and TRK oncogenes and with BRAF-V600E and RAS gene mutations. These last two genetic lesions are also present in a fraction of PDTCs. The ERK1/2 pathway, downstream of the known oncogenes activated in PTC, has a central role in thyroid carcinogenesis. In this study, we demonstrate that the BRAF-V600E, RET/PTC, and TRK oncogenes upregulate the ERK1/2 pathway's attenuator cytoplasmic dual-phase phosphatase DUSP6/MKP3 in thyroid cells. We also show DUSP6 overexpression at the mRNA and protein levels in all the analysed PTC cell lines. Furthermore, DUSP6 mRNA was significantly higher in PTC and PDTC in comparison with normal thyroid tissues both in expression profile datasets and in patients' surgical samples analysed by real-time RT-PCR. Immunohistochemical and western blot analyses showed that DUSP6 was also overexpressed at the protein level in most PTC and PDTC surgical samples tested, but not in ATC, and revealed a positive correlation trend with ERK1/2 pathway activation. Finally, DUSP6 silencing reduced the neoplastic properties of four PTC cell lines, thus suggesting that DUSP6 may have a pro-tumorigenic role in thyroid carcinogenesis. © 2013 Society for Endocrinology. Source
Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: Clinical activity and modulation of angiogenesis and lymphangiogenesis factors
Del Vecchio M.,Unit of Medical Oncology 2 |
Mortarini R.,Human Tumors Immunobiology Unit |
Canova S.,Unit of Medical Oncology 2 |
Di Guardo L.,Unit of Medical Oncology 2 |
And 9 more authors.
Clinical Cancer Research | Year: 2010
Purpose: To assess the clinical and biological activity of the association of bevacizumab and fotemustine as first-line treatment in advanced melanoma patients. Experimental Design: Previously untreated, metastatic melanoma patients (n = 20) received bevacizumab (at 15 mg/kg every 3 weeks) and fotemustine (100 mg/m2 by intravenous administration on days 1, 8, and 15, repeated after 4 weeks) in a multicenter, single-arm, open-label, phase II study. Primary endpoint was the best overall response rate; other endpoints were toxicity, time to progression (TTP), and overall survival (OS). Serum cytokines, angiogenesis, and lymphangiogenesis factors were monitored by multiplex arrays and by in vitro angiogenesis assays. Effects of fotemustine on melanoma cells, in vitro, on vascular endothelial growth factor (VEGF)-C release and apoptosis were assessed by ELISA and flow cytometry, respectively. Results: One complete response, 2 partial responses (PR), and 10 patients with stable disease were observed. TTP and OS were 8.3 and 20.5 months, respectively. Fourteen patients experienced adverse events of toxicity grade 3-4. Serum VEGF-A levels in evaluated patients (n = 15) and overall serum proangiogenic activity were significantly inhibited. A significant reduction in VEGF-C levels was found in several post-versus pretherapy serum samples. In vitro, fotemustine inhibited VEGF-C release by melanoma cells without inducing significant cell death. Serum levels of interleukin (IL)-10 and IL-12p70 showed the highest levels in sera of PR patients, compared with patients with stable or progressive disease whereas IL-23 showed the opposite pattern. Conclusions: The combination of bevacizumab plus fotemustine has clinical activity in advanced melanoma and promotes systemic modulation of angiogenesis and lymphangiogenesis factors. ©2010 AACR. Source
Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanoma
Anichini A.,Human Tumors Immunobiology Unit |
Molla A.,Human Tumors Immunobiology Unit |
Vegetti C.,Human Tumors Immunobiology Unit |
Bersani I.,Human Tumors Immunobiology Unit |
And 9 more authors.
Cancer Research | Year: 2010
CD8+ T cells at the earliest stage of effector generation have not been identified at tumor site of melanoma patients. Such early effectors, if present, should be characterized by a specific phenotype, distinct from that expressed at later stages of the antigen-induced differentiation program, by short-lived effector cells, memory precursors, and terminal effectors. Here, we show that neoplastic tissues from primary and metastatic lesions of melanoma patients contain a subset of CD8+ T cells expressing FOXP3. CD8 + FOXP3+ CD25+ T lymphocytes were found in tumor-invaded lymph nodes (TILN), s.c. metastases, and advanced primary lesions. Their frequency was significantly higher in TILN compared with tumor-free lymph nodes or with peripheral blood and in primary tumors compared with TILN. CD8+ FOXP3+ T cells did not express markers of regulatory [CTLA-4, CCL4, interleukin-10 (IL-10), transforming growth factor-β1], exhausted (PD-1), or senescent (CD57) CD8+ T lymphocytes. Instead, this subset showed an antigen-experienced "EM1" phenotype (CCR7 -. CD45RA- CD28+ CD27+) and exhibited a CD127-, KLRG1-, HLA-DR+, CD38 +, T-bet+, perforin+ "early effector" profile predicted by current models. CD8+ FOXP3+ T cells produced IFN-γ on short in vitro activation, recognized autologous tumor by CD107a mobilization, and expressed Ki-67 on ex vivo analysis. In response to autologous tumor plus IL-2/IL-15, the CD8+ FOXP3+ T cells proliferated promptly and showed competence for differentiation (downregulation of CD27 and upregulation of T-bet). These results suggest development of early phases of antitumor immunity even in advanced melanoma. Moreover, the CD8 + FOXP3+ "early effector" subset may be an invaluable tool for monitoring immunity at tumor site. ©2010 AACR. Source
Loria R.,Regina Elena Cancer Institute |
Bon G.,Regina Elena Cancer Institute |
Perotti V.,Human Tumors Immunobiology Unit |
Gallo E.,Regina Elena Cancer Institute |
And 10 more authors.
Oncotarget | Year: 2015
We used whole genome microarray analysis to identify potential candidate genes with differential expression in BRAFV600E vs NRASQ61R melanoma cells. We selected, for comparison, a peculiar model based on melanoma clones, isolated from a single tumor characterized by mutually exclusive expression of BRAFV600E and NRASQ61R in different cells. This effort led us to identify two genes, SEMA6A and MICAL1, highly expressed in BRAF-mutant vs NRAS-mutant clones. Real-time PCR, Western blot and immunohistochemistry confirmed preferential expression of Sema6A and Mical1 in BRAFV600E melanoma. Sema6A is a member of the semaphorin family, and it complexes with the plexins to regulate actin cytoskeleton, motility and cell proliferation. Silencing of Sema6A in BRAF-mutant cells caused cytoskeletal remodeling, and loss of stress fibers, that in turn induced cell death. Furthermore, Sema6A depletion caused loss of anchorage-independent growth, inhibition of chemotaxis and invasion. Forced Sema6A overexpression, in NRASQ61R clones, induced anchorage-independent growth, and a significant increase of invasiveness. Mical1, that links Sema/PlexinA signaling, is also a negative regulator of apoptosis. Indeed, Mical-1 depletion in BRAF mutant cells restored MST-1-dependent NDR phosphorylation and promoted a rapid and massive NDR-dependent apoptosis. Overall, our data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. Source


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Nanny's Day: Revelation
A bouquet arrives for Elisabeth - the Nanny. Turns out that Nanny is getting married to the Baron of Clearwood, and the wedding is next week. Wendy and Cloe want to make sure the prospective husband is good enough for the Nanny, so they go on a mission to see whether the Baron can be seduced by two hot college girls.
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STRAUSS'S MARSCHALLIN in Der Rosenkavalier is supposed to be aged 32, but the part is usually taken by a singer rather further into her years. In fact, there is an accepted progress from the ingenue role of Sophie to the senior part, normally reserved for an established diva.
The Scottish Opera's Marschallin, Joan Rodgers, is, of course, an established diva. However, with her slight and pretty figure she looks like a young girl, and the voice is essentially lyric. Given the customary suspension of disbelief, she would pass excellently as Sophie, with, say, Anne Evans as the Marschallin. Casting Rodgers as the older woman put a strain on the Sophie (here, the brightly focused Lisa Milne), who had to seem younger and prettier, and on the whole balance of the action, for the opera is chiefly about a woman who sees her youth slipping away.
This strain was worsened initially by a conductor, Richard Armstrong, who held the rhythms too tightly corseted. He relaxed a little as things progressed. The effect was to give a special poignancy to the end of Act 1, in which Rodgers wistfully recalled her teenage years; the soft warmth of the voice, the bewitching smile that hovered always near her lips, the quiet self-possession, gave the lightest of touches to this moment of pathos, a bit shallow but nevertheless heartfelt. As the grand patrician, she was less credible, and you worried that she might lose control of the stageful of dubious characters in Act 3.
Indeed, it was a bit of a surprise when this young, pretty thing was able to command the boy Octavian out of the room at the close of Act 1. For this Octavian (Stella Doufexis) was a tall, gallant, fiery character with flashing eyes and a voice that was vibrant and comprehensive. It was a totally convincing portrayal of the impulsive young male.
If Rodgers shed a new light on the Marschallin, then Peter Rose gave a new meaning to Baron Ochs. A heavyweight baritone, he was able to give force and power to what is usually a boorish pantaloon; you felt for him when he longed for the unsophisticated country life in a Vienna of tricks and conspiracies.
It was impressive how closely these fine principals had worked with the producer, David McVicar. Any producer can get the chorus to group well, but to get soloists to turn their heads away at just the moment when the harmony clouds, or to slow in mid-gesture when Strauss suddenly imposes a piano, takes real authority. McVicar had designed his own set, an elegant room with heavy drapes and candles, and Tanya McCallin provided sumptuously colour-coded costumes.
There were some precious vignettes: Joanna Campion was a snakey Annina, Phyllis Cannan a ludicrously shocked Marianne, and Harry Ward, in the non-singing part of Ochs' bastard Leopold, was a deliciously greasy sloven. There was plenty to admire in this production; even the audience at the Theatre Royal, Glasgow, showed some real enthusiasm for once.
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The in-system programmable device consolidates four differential or eight single-ended clock generators, and can store up to four different configuration settings, helping to minimise board space and bill-of-materials. With RMS phase jitter less than 0.7 psec over the full 12 kHz to 20 MHz integration range, the new device meets the stringent jitter requirements of PCI Express Gen 1/2/3, USB 3.0, and 1G/10G Ethernet. The high-performance clock generator operates at less than 100 mW core power (50% lower than competing devices), helping to ease system thermal constraints, reduce operating power expenses, and maximise battery life.
The 5P49V5901's four universal output pairs are each independently configurable as HCSL, LVPECL, LVDS, or dual LVCMOS outputs. The fractional output dividers driving each output pair are programmed via I 2C while the device is operating in the system, lending itself to system tuning and margin testing. Unlimited in-system reprogramming is possible via I 2C, whereas four banks of one-time programmable non-volatile memory provide flexibility for multi-project inventory consolidation or design changes in field or production units. Devices may be factory-programmed to the customer's desired configuration. The device is available in a 24-lead 4x4mm VFQFPN package.
Integrated Device Technology; www.IDT.com


text: Just Who Will Arnold Schwarzenegger Be Playing in Terminator 5?Katharine Trendacosta7/01/13 9:00amFiled to: Morning SpoilersKick-Ass 2Avengers 2The WolverineThe World's EndPacific RimTransformers 4Doctor WhoWarehouse 13Once Upon a TimeRevolutionTrue BloodUnder the DomeArrowVampire DiariesTomorrow PeoplePerson of InterestSupernaturalFalling SkiesTerminator 5Amazing Spider-Man 2Captain American: The Winter SoliderRiddick1402EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Captain America 2 will be rougher than other Marvel movies. There are huge rumors about another Amazing Spider-Man 2 villain and a Doctor Who shake-up. Plus Kick-Ass 2 releases new viral videos, Stephen King's has a message for book fans watching Under the Dome, and Optimus Prime has a bad day in Transformers 4. Spoilers... Captain America: The Winter SoldierJoe Russo promises, "It's going to be much grittier than any Marvel movie to date." Advertisement [Cinemablend]Kick-Ass 2Two new viral videos for the movie have been released. The first features "Battle Guy" and "Insect Man":And the second comes from "Doctor Gravity":Avengers 2Joss Whedon's talked some more about the role Quicksilver and the Scarlet Witch will play in the sequel: Advertisement [They're] a huge part of [Avengers 2]. I'm really excited about it. I don't know what they're doing and I'm determinably not knowing. They'll do their thing. I have to do mine.There's more in the video at the link. [Crave Online]Amazing Spider-Man 2This new movie will be introducing both Harry Osborne (Dale DeHaan) and his father Norman (Chris Cooper) — but a new rumor, supposedly from a source who witnessed the tail end of filming, suggests that Norman won't be becoming the Green Goblin at all. Instead of the mantle of Green Goblin being passed from father to son, Harry will be the first and only Green Goblin — and he'll suit up at the end of this movie, during a showdown at an OsCorp power plant. As with all rumors, a large grain of salt is advised here. [Movie Web]Terminator 5MTV has a roundup of facts, rumors and guesses about the new movie — among them is the notion that if Arnold Schwarzenegger is really coming back, he'll have to be playing a human this time around. Because the two-term governor of California simply looks "too haggard" to play a ruthless killing machine. So maybe he plays the human whose badassery inspires Skynet to create the T-800 in his image? (Assuming, of course, that you ignore that Terminator 3 deleted scene.) Advertisement One rumor is that the film takes place in the 1940s or 1950s, where a Terminator is sent back to try and wipe out John Connor's ancestors earlier in his bloodline — in which case Schwarzenegger would be the guy who saves the Connor clan, and winds up inspiring the appearance of the T-800. Take all of this with several grains of salt, of course. [MTV]Jeff Nichols' Untitled MovieJeff Nichols, director of Mud and Take Shelter, is directing a brand new movie that's said to be "a present-day scifi chase film." Now Joel Edgerton (Zero Dark Thirty) is joining Michael Shannon in the movie's cast. And there's some supposition the film is actually the Starman-inspired Midnight Special, a movie that Nichols mentioned he was writing some time back. [Variety via First Showing]The WolverineSlashfilm has released the full transcript of its interview with Director James Mangold. Here are some interesting tidbits. Advertisement Sponsored On how he's using the comic storyline:In [Frank] Miller's storyline he's got a preexisting relationship with Madripoor. Well, that would be really weird to just open a movie and he's already been to Japan. In a way I had to do the origin story of his relationship with Japan. Like if there was something I had to introduce it was so that you're not only falling into a new point in his own life, but you're falling into a place where he's already made a host of new connections and you don't know how any of them came to pass. So there's very simple redirection like that that we made.And on Viper: Advertisement The thing is… the reason that I hesitate is that I don't want to give away the surprise, but more to that, the movie is a mystery. The movie itself is kind of a labyrinth. Everyone's got secrets and everyone's got surprises, not just Viper. The joy of the film to me is trying to figure out, like Logan is… You land in this Oz, you don't really have your feet planted on the ground, you don't know the way things operate here and you don't know the language. So there's a level where the interesting quality of the movie is watching him with us unpeel what the hell is going on.There's a ton more at the link. [Slash Film]The World's EndHere's a new UK TV spot:RiddickVin Diesel released this San Diego Comic Con poster. [via Flickering Myth] Transformers 4Michael Bay has released a photo of a new vehicle that'll be in the next film called "The Freightliner." [MichealBay.com] It looks like Transformers 4 is looking for extras for its Hong Kong scenes, since it's placing a casting call for Asian American adult extras for scenes being filmed in Michigan that'll apparently be combined with actual shots in Hong Kong. [WZZM 13 ABC] Advertisement Advertisement Here are some videos from the set of Optimus Prime getting blasted with huge explosions. [via Transformer World]And finally, here's a picture of a prop. [Transformer World] Doctor WhoReece Shearsmith, who will playing Patrick Troughton in the the 50th anniversary biopic An Adventure in Space and Time, has revealed the extent to which the second Doctor will be featured: Advertisement Advertisement I was honoured to be part of it. Mark [Gatiss] has... had that idea for a long time and he's finally got to do it this year. It's the perfect time for it to happen, with it being the 50th anniversary in November. I think he just always had this idea that I would [play Troughton]. It's very small - I'm literally only in a very small little bit, but it was lovely to be part of it.[RTE]Now, take this with a grain of salt, but there's some evidence that producer Marcus Wilson will soon be leaving the show. He posted this semi-cryptic tweet: Advertisement [Former Eastenders producer] Diederick Santer gave me lots of good advice. The best - always leave the party while you're still having fun.Wilson joined the show during Matt Smith's second season — and with the recent departure of Caroline Skinner, he was one of the main points of continuity in the show's production office. If it's true Wilson is leaving, then as Life, Doctor Who & Combom puts it, Steven Moffat "is essentially going to be breaking in an entirely new production team" along with a new Doctor. Wilson has neither confirmed nor denied that he's leaving, but people are taking this tweet as implying that to be the case. [Life, Doctor Who & Combom]Warehouse 13Rebecca Mader has been cast for a single-episode part in Warehouse 13's six-episode final season. Exactly what her role will be is being closely guarded, however. [TV Line]Once Upon a TimeOnce Upon a Time is casting two recurring roles for the season premiere. The first is Rufio, a "mischievous and devious" Lost Boy and "Thief," a man in his 30s who steals magic from Rumpelstiltskin to save someone he loves. [SpoilerTV]RevolutionJessica Collins has been cast as the recurring character Cynthia, described by Executive Producer Eric Kripke as "a beautiful young woman of deep faith, whose winning humor and blazing intelligence capture the heart of one of Revolution's leading characters." [EW] Advertisement Advertisement The season premiere will also feature Jeff, "a sexy bartender." [Spoiler TV]Under the DomeHere, in all its glory, is Stephen King's response to anyone complaining about the differences between the show and the book:For those of you out there in Constant Reader Land who are feeling miffed because the TV version of Under the Dome varies considerably from the book version, here's a little story. Near the end of his life, and long after his greatest novels were written, James M. Cain agreed to be interviewed by a student reporter who covered culture and the arts for his college newspaper. This young man began his time with Cain by bemoaning how Hollywood had changed books such as The Postman Always Rings Twice and Double Indemnity. Before he could properly get into his rant, the old man interrupted him by pointing to a shelf of books behind his desk. "The movies didn't change them a bit, son," he said. "They're all right up there. Every word is the same as when I wrote them."I feel the same way about Under the Dome. If you loved the book when you first read it, it's still there for your perusal. But that doesn't mean the TV series is bad, because it's not. In fact, it's very good. And, if you look closely, you'll see that most of my characters are still there, although some have been combined and others have changed jobs. That's also true of the big stuff, like the supermarket riot, the reason for all that propane storage, and the book's thematic concerns with diminishing resources. Many of the changes wrought by Brian K. Vaughan and his team of writers have been of necessity, and I approved of them wholeheartedly. Some have been occasioned by their plan to keep the Dome in place over Chester's Mill for months instead of little more than a week, as is the case in the book. Other story modifications are slotting into place because the writers have completely re-imagined the source of the Dome.That such a re-imagining had to take place was my only serious concern when the series was still in the planning stages, and that concern was purely practical. If the solution to the mystery were the same on TV as in the book, everyone would know it in short order, which would spoil a lot of the fun (besides, plenty of readers didn't like my solution, anyway). By the same token, it would spoil things if you guys knew the arcs of the characters in advance. Some who die in the book—Angie, for instance—live in the TV version of Chester's Mill…at least for a while. And some who live in the book may not be as lucky during the run of the show. Just sayin'.Read the whole thing at the link. [StephenKing.com] Advertisement Mike Vogel spoke to TV Line about Barbie's unlikely hero-dom:There certainly are some things starting to bubble with Barbie and Julia. There's always that underlying skepticism, which continues to get played even more so in the next episode. This week we have a big fire that breaks out, and in a normal circumstance that's a difficult situation — but you put it in a small town under a dome where your fire department is stuck on the outside? Now you're faced with a situation where the entire town could go up....Escaping [the dome] is left to some other characters. Barbie's just trying to cover his tracks. He's in a town that he wants to avoid and disappear in as much as possible, but he keeps finding himself drawn into these situations where, because he is a good guy, it's innate in him to protect and to defend. As much as he tries keep a low profile, things keep happening that force him to intervene.More at the link. [TV Line]Britt Robertson spoke to TV Guide about what life will be like for Angie in the bunker: Advertisement Advertisement When I first met with [executive producers]Brian [K. Vaughan] and Neal [Baer] before we even started shooting, they mentioned this idea that Angie has this way with not even just men, but people in general where she can manipulate them and get what she wants very easily by using different tactics. In a way, she's been doing this her entire life. When she gets trapped in this fallout shelter with a guy who she's known for the majority of her life — she knows him probably better than anyone — she uses every skill, every tactic, every manipulation that she can to get out of there. Ultimately, he's just not the person who she thinks he is. It's a really fascinating frustration for Angie because she's fighting being able to control him and manipulate him, yet she's being entrapped by this guy who is just insane. There's no reasoning with him....[Angie] does see her brother before she gets trapped, so the audience is going to think, "Why isn't her brother looking for her? He knows she's in the dome along with everyone else." But it goes back to who she is. She's a really independent free spirit. She has her own apartment and does whatever she wants to. There is the threat of maybe something happened to her, but there's also the reasoning, 'That's just Angie.' That's terrifying for her as well, because no one is really looking for her at all.There's plenty more at the link. [TV Guide]And the synopses for episodes 1.07, 1.08, and 1.09: Advertisement The title of episode 1.07 has been changed to "Imperfect Circles" in later casting notices (previously it had been "Broadcast Signal Intrusion"). In episode 1.07, in their search for the source of the dome, Joe and Norrie discover that there's a "mini-dome" in the woods with an egg inside of it that has pink streaks moving down its sides.In episode 1.08, "Thicker Than Water," Junior teams up with Ollie against Big Jim. Barbie, Big Jim, and Linda plan to blow up Ollie's well to divert water back to the town's reservoir.In episode 1.09, "The Fourth Hand," Joe and Norrie discover that the mini-dome has reappeared in Joe and Angie's barn. The new character Maxine ("Max") first shows up in episode 1.09. Max has a history with both Big Jim and Barbie, and she knows that Barbie killed Julia's husband because she was the person he called in the car after he buried Peter. She's also been behind the drug "Rapture" that several of the townspeople have been taking, and she's part of Big Jim's deal to stockpile propane.[Spoiler TV]ArrowHere's a behind the scenes photoshoot photo of Kate Cassidy. [SpoilerTV] True BloodHere are the synopses for episodes 6.05, 6.06, and 6.07: Advertisement Advertisement Episode 6.05 - F**k the Pain AwayWanting to finally learn the truth about her past Sookie recruits Lafayette to summon her parents while Warlow relives the events that led him back to Lilith after thousands of years, Eric and Tara attempt to rescue Pam.Episode 6.06 - Don't You Feel MeSookie escapes to a Fae land where Bill cannot influence her. Bill decides to seek Lillith's advice. Eric, Pam, Nora, Jason and Jessica are in danger.Episode 6.07 - The FuneralEric pledges loyalty to Bill as a last resort to save Nora. A tragedy close to home forcES Sam to ignore the warnings of Alcide and return to Bon Temps. Jessica shows her gratitude to James, a prisoner.[SpoilerTV]Jamie Gray Hyder spoke to Buddy TV about the pack and this season. Advertisement On Danielle's place in the pack:I think as her role on the show has increased, so has her role in the pack. I think that she's very much an opportunist. Last season, she was willing to do V and also other stuff to impress the pack leader who was in power. And now there's a new pack leader and she's vying for his attention. I think that she just wants to go along and be part of what's going on and prove that she's a viable asset to the pack.On Danielle's relationship with Alcide:I think [she's] going to continue to do whatever [she] can to appear valuable to him and the dynamics of everybody kinda changes throughout the season as we continue.And on the place of werewolves in the human-vampire war: Advertisement Advertisement I think we're trying to keep to ourselves as best as possible. We're trying to look out for our own, but there's no doubt that with such a big conflict going on in Bon Temps and in the State of Louisiana that we'll be able to stay out of the conflict. You saw the young group that came into Merlotte's and they were spying on us. So, we don't know what's going to happen with all that. Everybody is a target at this point. You can't help but be involved in the conflict that's going on at large.There's more at the link. [Buddy TV]Vampire DiariesThe first episode of season 5 is casting some new characters. In the season opener, we'll meet: Advertisement Nadia - And emotional and beautiful 20's something who has traveled the earth on a mission of vengeance.Jesse - Mid 20's, college upperclassman.Megan - 20's and head of her class, too smart for her own good.The third episode will introduce another recurring character, "Tessa" — a "powerful and insightful" nobleman's daughter. [SpoilerTV]The Tomorrow PeopleHere's a promotional photo of Mark Pellegrino. [Spoiler TV] Person of InterestThe first episode of season 3 will be called "Liberty." [SpoilerTV]SupernaturalThe season premiere will be called "Devil May Care" and feature Tracy, a hunter, and Irv, another hunter who is an old friend of the Winchesters. [Spoiler TV]Falling SkiesTV Equals interviewed Noah Wyle, Drew Roy, and Doug Jones about what is coming up this season. Watch their answers in the interviews below:Reply140 repliesLeave a reply


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Science & Medicine, Natural Sciences, Society & CultureFollow
|Science & Medicine
|Natural Sciences
Deep in the back of your mind, you've always had the feeling that there's something strange about reality. There is. Join Robert, Joe and Christian as they examine neurological quandaries, cosmic mysteries, evolutionary marvels and our transhuman future on Stuff To Blow Your Mind, a podcast from HowStuffWorks.com.
November 25th, 2010
Episode 91 of 798 episodes
Each week, Robert and Julie bring you fascinating, mind-blowing stories about the strangest things in the natural world -- but how could your mind literally be blown? Tune in and learn more in this podcast.
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Welcome to the daily audio workout for your head.


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Pittsburg is located in Crawford county and has a population of 19,243.
Sociology schools in Pittsburg charged students an average tuition of $3,652.00 if they were Kansas residents, and $12,176.00 if they were non-residents, during the 2009 - 2010 school year.
Books and supplies for sociology schools in Pittsburg cost an average of $1,000.00. Students who live on campus while attending a sociology school in Pittsburg, can expect to pay an average of $6,120.00 for room and board. Students who live at home can expect average costs to be $3,510.00. Students have a choice of one sociology college in Pittsburg to attend. In the 2008 - 2009 school year, reportedly 53 students completed sociology programs in Pittsburg.
|Average Salary
|Number Employed in City
|Sociology Teachers, Postsecondary


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—Wireless Sensor and Actuator Networks (WSAN) and permanent connections to the Internet converge to be an emerging and promising field: Machine-To-Machine (M2M) services. To take advantages of this new field, hardware and software infrastructure compliance must be verified. Services expected by M2M alter the organization of WSAN. The software design in this… (More)
In this paper, we propose a comparative study between results generated by a real 802.11 testbed in different outdoor and indoor environments and 3 usual network simulators (NS2, QualNet and OPNET). The goal of this study is to evaluate the relevance of the low layers recently implemented in these simulators. The motivation of this paper is to provide a… (More)
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt età la diffusion… (More)
and Smart Objects (i.e. objects with processing and networking capabilities) are more and more present in everyday's life. Merging all these technologies with the Internet is often described as 'Internet of Things' (IoT). In the IoT vision, Things around us provide a pervasive network of interacting and interconnected devices. However building IoT… (More)
—The increasing interest about the Internet of Things (IoT) is almost as remarkable than its practical absence in our everyday lives. Announced as the new breakthrough in IT industry, the domain is characterized by a large number of architecture propositions that are in charge of providing a structure for applications creation. These architectures are… (More)
In this work, we present a complete architecture for designing Internet of Things applications. While a main issue in this domain is the heterogeneity of Objects hardware, networks and protocols, we propose D-LITe, a solution to hide this wide range of low layer technologies. By abstracting the hardware, we focus on object's features and not on its real… (More)


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Wood Designs™ 36"H Tray and Shelf Fold Storage Without Trays, Blueberry
Item # 901-509325
Model # WD23639B
Not yet rated. Be the first toWrite a Review
Wood Designs™ 36" Tray/Shelf fold storage in blueberry color is suitable for use in schools and allows ample storage for small/not so small necessities. Wood Designs™ 36" Tray/Shelf fold storage in blueberry color is made of 100 percent healthy kids plywood that does not emit any harmful contaminants into atmosphere. Storage has tuff gloss UV finishing for safety.
- Blueberry
- Hinged with a locking hasp for convenience
- 36"(H) x 96"(W) x 15"(D) (opened), 48"(W) x 36"(D) (closed)
- 100% healthy kids plywood
- Finish: Tuff gloss UV
- Fully assembled
- We've hinged a single storage unit with a 25 clear tray storage unit to create ample storage for small and not so small necessities
- On heavy duty casters for mobility
- All surfaces and back are 100% Healthy Kids™ Plywood with our exclusive tuff gloss™ UV finish
- GREENGUARD children & schools certified
- Weight: 201 lbs.
- Warranty: Lifetime limited
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News & Events
Family & Children's Service will celebrate 75 years of service to the Nashville community with huge Birthday Bash February 25th, 2017!! The party will be held at 2400 Clifton Avenue, the warehouse location where we will build a new home for FCS, just a mile from our current location in Midtown Nashville.
We would love for you to join us for this once-in-a-lifetime event. To purchase tickets or a table for this event, please click here.
We've partnered with Lyft to offer exclusive ride discounts to our 75th Birthday Bash! New to Lyft?: Get two free rides (up to $10 each) at http://lyft.com/i/fcs20 or download the app and enter code FCS20.Already Have Lyft?: Save 15% off two rides to or from the Family & Children's Service 75th Birthday Bash with code FCS15
A limited number of event and table sponsorships remain. Please contact Beth Raebeck Hall for more information at 615-340-9718.
For more information about the new home we are building for FCS (and the location for this exciting party) click here.
Presenting Sponsor:
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Catering by Johnny Haffner
Douglass Financial Services
Helping Hands
Business Partners:
- Allegra Printing
- Amy Atkinson Public Relations
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- First Farmers and Merchants Bank
- J. Leo Richardson
- Monroe Carrell Jr. Children's Hospital
- Music City Dixieland Band
- MTR Family Law
- Smythe & Cortlandt
- Kim & Bill Troupe


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Panton chair
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Panton Chair designed by Verner Panton for Vitra
l-e-m-i-n-i-m-a-l-i-s-m-e: Panton Chair Classic _Verner Panton, 1959/1960 | vitra
rustic farmhouse table + Panton chairs + bubble pendant + chalkboard wall via style at home
Panton's Plastic Chair - in miniature form! Who knew there was a site called MiniatureChairs.com?
dining room - interior design by Maven
panton-green-nuevo-estilo - Design Milk
Via Room of Karma | Panton | Arne Jacobsen | Andy Warhol Poster | Pia Wallen | Black and White
Concrete table Dinning room #dinningroom
Casa Olivi, a heritage protected building in the Marches of Italy, has been renovated by its owners into a luxurious holiday home. Design by Swiss architects Markus Wespi and Jerome de Meuron - Panton chairs
Freischwinger Panton Chair


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At the Old Town you can enjoy a walking tour passing by the Castle Square, King Sigismund's Column, St. John's Cathedral, the Old Town Market Square and the Barbican.
Recent Photos of this Tour
Schedule details
Select a month to view a calendar of availability and departure details.
Pricing information
Click the link below to check pricing & availability on your preferred travel date. Our pricing is constantly updated to ensure you always receive the lowest price possible.
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Pricing information
Half Day Sightseeing Tour of Warsaw
- Hotel pickup and drop off
- Food and drinks, unless specified
- Gratuities (optional)
- Confirmation will be received at time of booking
- Adult pricing applies to all travelers
Cancellation Policy
If you cancel between 3 and 6 day(s) in advance of the scheduled departure, there is a 50 percent cancellation fee.
If you cancel within 2 day(s) of the scheduled departure, there is a 100 percent cancellation fee.
Traveler Reviews
Reviewed by: Ragnhild H, November 2016
The guide was very good and gave an excellent overview of Warsaw's main sights. The walk through the gardens was just beautiful with the autumn colours and lovely old buildings . There were 2 periods of 45 minutes of walking at a manageable pace. I would definitely recommend this tour.
Reviewed by: mootaz84, October 2016
Very good tour that gave me a true taste about the city. Our tour guide Paul was informative and knowledgable. Recommended at the start of your visit to move your head around the city.


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Have a fast access to the employment data is a great thing to consider. While working, you can't waste your time since it will influence your income. That is why the postal employee is the key for effective management. Paperless Pay Talx is one of the postal employees that have a lot feature to access. The user will get the benefits such as accessing the schedule or paystub. Somehow, the employment data is an individual need for certain reason. For example, the employee that paid for each hour working.
The schedule of work in postal employee will be necessary. The data will help the worker to make the prediction about the fee. It will also help to arrange the self-time management. So the company and employee will get the benefits as well. If you are a newcomer, then you should make activation over your account. You need the account access to see all the employment data. If you wonder how then you can find it out by reading this article.
The Paperless Pay Talx is a helpful tool for all the employees. It gives the complete information that important and crucial. The payroll, schedule, and work benefits can get access through this portal system. Every company in an excellent range will use the employee system to keep in touch with the workers. Using the portal system helps you to be efficient in time. You don't have to find your file in HR department. Just use the account login details to make access to your employment archives. Indeed, you can do it anytime you want. Since it is a system based on online, as you get the internet connection you can access it.
Before you access the Paperless Pay Talx portal, be sure you get some stuff. First, you must have the device to open the page. It can be the laptop, PC or smartphone. No matter your device is sure you have the browser application. The famous ones are Mozilla Firefox, Google Chrome, and Internet Explorer and so on. After that is make a connection between your devices with internet signal. If you access it in the office, you will not feel hard to get internet access.
The offices today are completing themselves with WIFI for the workers. But if you try to access the portal outside the workplace, be sure you have your internet access. Or you can go to the public area which provides free WIFI to access. If you get them all, now it is the time to access your account in Paperless Pay Talx. Here are the simple steps you need to follow:
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If you pass the login process, you will see your account then. You can reset the account profile or access the employment data. All the information is available. You just need to click on the link or button you need.


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Spotlight Article:
When Above Average Is Not Good Enough
Let's imagine two neighboring families on a residential block—the Joneses and the Smiths. Their homes are of comparable size and age, and both are families of four, living typical middle-class lifestyles. ...
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Rock Dog
I can report that it enraptured and delighted, and most importantly, made quiet, the houseful of little kids and their nannies with which I watched…
I can report that it enraptured and delighted, and most importantly, made quiet, the houseful of little kids and their nannies with which I watched…
We need more directors willing to take risks with films like Get Out.
Roger Ebert on James Ivory's "Howards End".
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
An Ebert Fellow on films and programs from Sundance that focus on the environment.
A report on three documentaries from Sundance that tackle race relations in the era of Black Lives Matter.
A news brief on the Agnès Varda exhibition set to premiere at New York's Blum & Poe on Thursday, March 2nd.
The boy loves soccer.
Jana Monji journeys to the legendary Disney vaults to learn more about the creation of Disney's "Pinocchio."
Four honorees were celebrated during a special luncheon preceding the African American Film Critics Association awards on February 8.
The RogerEbert.com staff's Oscar pick for Best Picture.
The RogerEbert.com staff's Oscar pick for Best Director.
Well, I guess this is the movie I've been asking for. Whenever I see a superhero epic, I'm always nagged by logical questions -- like, when the Incredible Hulk becomes enormous, how do his undershorts also expand? "Big Man Japan" answers that question with admirable clarity. Before the Big Man grows, workers winch an enormous pair of undershorts up on two poles, and he straddles the crotch. Then he expands to fill them. Had to be something like that.
The movie, which is very funny in an insidious way, takes the form of a slice-of-life documentary about Daisoto (Hitosi Matumoto), the latest generation in a Tokyo dynasty of monster-killers. He is a quiet, introverted, unhappy man whose wife has left him and taken away their daughter. He lives alone in cluttered bachelor squalor. Nothing much happens, but he's always on call, and when the Department of Defense needs him, he has to rush to the nearest power plant, be zapped with massive bolts of electricity and grow into a giant ready to battle the latest monster with his only weapon, a steel club.
These are some monsters. One has expanding cables for arms, embraces skyscrapers, pulls them out of the ground and throws them over his back. Then he has to flick his comb-over back in place. One consists of a giant body and one foot, with which he jumps on things. One exudes an overpowering stink. One breathes fire and looks like Hellboy. One has a single giant eyeball on a long stem hanging from its crotch and wields it like a bola.
These monsters come from who knows where, and when they die, we see their souls take flight and ascend to heaven. Their battles take place in cities that look gloriously like phony special effects, and unlike most monster movies with terrified mobs, these streets and buildings do not have a single person visible. In contrast with the action scenes, the movie takes the form of a downbeat doc about the nightmare of being the Big Man.
Daisoto never gets time off. He isn't paid much. He raises cash from TV specials about his fights and selling advertising space among his tattoos. People hate him for stepping on things, soiling the environment and disturbing the peace. His TV ratings are down. He wonders why his agent, a chain-smoking, cellphone-addicted woman, has a new car but he takes the train. His only company comes from professional geishas.
Matumoto plays the role absolutely on the straight and level. So do all of the human characters. He is as concerned about the practical problems of being a superhero as I am. The film takes, or seems to take, his dilemma with utter seriousness. Matumoto is also the writer and director, and it becomes clear that he is satirizing three genres: the personal documentary, monster movies and reality TV. And he does this slyly, with a scalpel instead of a hatchet. Only the monsters are over the top, and are they ever. The weird thing is that thanks to CGI, some of them have worried middle-aged human faces on their grotesque bodies.
Note: Something has been nagging you. That name Matumoto doesn't seem quite right. You would be correct. Hitosi Matumoto's real name is Hitoshi Matsumoto, but both names are misspelled in the credits. Little joke. Think Ada Sadler. He's a popular Japanese comedian. I hope all his overseas viewers get the joke.
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At the ripe age of 89, Oscar can still be a notoriously picky fellow when it comes to what constitutes a contender fo...
Our resident awards expert predicts who will go home with an Oscar on Sunday night.


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Lowe Secures Financing Via Hilton Brands
Monday January 14th, 2013 - 11:56AM
These are shortcuts to your favorite social networking and bookmark sites. Add this story to your Facebook page, del.icio.us, DiggIt, and many others!
NEW YORK—Cushman & Wakefield served as the exclusive advisor to an affiliate of Lowe Enterprises Investors, a national real estate investment manager, in arranging up to $33.3 million of non-recourse, floating rate financing secured by the Doubletree by Hilton Hotel Boston-Bedford Glen and the Embassy Suites Chicago-North Shore/Deerfield.
The facility includes future funding elements associated with a property improvement plan and an earn-out. Financing was provided by CapitalSource.
The Doubletree, a 281-key, leading full-service hotel, is located at 44 Middlesex Turnpike in the I-95 West Boston submarket. The Embassy Suites, a 237-key, all-suites property, is located at 1445 Lake Cook Road in Chicago's North Shore area.
Lowe Enterprises Investors acquired the hotels on behalf of a separate account client during fourth-quarter 2011.
Destination Hotels & Resorts, a wholly owned subsidiary of Lowe Enterprises, assumed management of the hotels following the purchase.
Jared Kelso and Ernest Lee of Cushman & Wakefield's U.S Hospitality Group represented the borrower in arranging the financing.
Tags: • Hospitality • Brokers • Ownership • Management Companies •
In this issue, you'll find our report from ALIS (Americas Lodging Investment Summit), which was held at the end of last month in Los Angeles. In fact, many of you were probably among the 3,000 industry professionals there. The theme of ALIS 2017? "Please Stand By." But many industry leaders are choosing just the opposite and instead of staying static, are moving ahead with plans and projects—and forward-thinking initiatives.
Ascent Hospitality Acquires Marriott in Huntsville, AL »
Hyatt Launches "For a World of Understanding" Campaign
FelCor Offers Clarification on Ashford Acquisition Proposal
Former French President Sarkozy Joins AccorHotels' Board
Wynn Resorts Names Craig S. Billings as CFO
Outrigger Positions Itself for Future Growth
The James New York-NoMad Sets Summer Opening
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Galaxy Painted Nails
Galactic nails #manicure #galaxy #cosmic
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By Pamada Kittipongtonr. #NewYearsEve #holiday I love the looks on Bloom Beauty Trends App!
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Croc Applique Leather Large Zip Pouch
Structured croc applique leather pouch with zip and croc leather wrist loop to close. Inside details include a zipped compartment for change and card slots. The Orange colorway features a navy Linear Stem jacquard lining, while the Sand colorway features sand Linear Stem jacquard lining.
This product is made from high quality leather. This leather will develop a rich patina as it is polished and cherished. Due to the nature and color of this leather please take care when wearing light clothing as color may be transferred. Please store in the dustbag provided.
Dimensions (in): H4.4 x W8 x D0.8 / Product Code: 16SBCAP206
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Recent Meetups
Aug 25, 2016 · 5:00 PMSmall Business Law - What you need to know!
Alan Arnott, Technology Lawyer from Arnotts Technology Lawyers will be presenting on Small Business Law 101. Come along to hear how you can save time and money by... Learn more
Aug 2, 2016 · 12:15 PMLearn Over Lunch - Perfect Your Pitch (Burwood)
Perfect your pitch workshop and networking In the world of pitching, you can say that behind every successful pitch is an interesting idea or an important message. And... Learn more
Jul 14, 2016 · 10:00 AMPop in and spend time working ON your biz not IN your biz
www.lisapenson.com Would you like to hang out in Sydney's biggest and newest creative hub, MakerSpace? Talk business with other like minded small business owners? Get a... Learn more
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Create your customer Avatar workshop. In business… and in life… you're not going to be everyone's cup of tea, and that's perfectly ok. The magic happens once you can... Learn more
Apr 12, 2016 · 12:15 PMLearn Over Lunch - Develop a 1 Page Business Plan (Burwood)
Come and join me in Burwood for a Learn Over Lunch and plan your next 12 months in Business! A business plan can be an important tool for any small business operator.... Learn more
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(770) 205-5633(770) 205-5633
1654 Buford Highway, Cumming, GA 30041
I want to thank you for your intrest in this store. Unfortunatly, this store has closed down and is no longer in business. Please do not try to contact the owner as he is no longer in the business at this time......
Posted: 10/22/2012 • Link to this review


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Hiddenbed Factory
furniture stores, Furniture Design, Office Furniture
Hiddenbed Factory manufactures and retails Hiddenbeds in Canada. Innovators of the original design, our models are built for strength. Wemake Hidden Beds, Murphy Beds and Hidden Desk units. Located in Woodbridge, Ontario, we ship across Canada.
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Innovative Hiddendesk manufacturer
Space saving Murphy wall beds.
The Hiddenbed Factory manufactures and installs Hiddenbeds, Murphy beds, Hidden Desks, Hiddenbed mechanisms, sales and service to parts and accessories. Since we are the main Hiddenbed manufacturer in Canada, we can customize any aspect of Hiddenbed, Murphy bed, Hiddenbed Desk system. We create space saving designs and solutions for maximizing space and innovate improvements to
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Question about George Foreman GR30 Indoor Grill
Posted by sanmar7 on
Clean with a soap soaked cloth over the kitchen sink ,while inclining on its side. Do not imerge in water.Rince thoroughly with clear water soaked cloth and dry with paper tissu.Its is the only simple way of cleaning the grill ,i have found.good luck
Posted on Nov 27, 2008
SOURCE: bottom plate replacment
theres lots of posts here regarding george foreman products.
there does,nt seem to be anywhere to buy replacement parts.
I,d suggest buying a new alternative product, with a more stable background, and reliable service and replacement parts. i.e russel hobbs or tefal et,c.
Mike @ Compurepair.
Posted on Feb 24, 2008
SOURCE: Brevill Grill Removable plates - dishwasher safe?
Greetings jackneve,
The manufacturers specifications would indicate these plates are indeed dishwasher safe!
I hope this helps!
Go Ahead. Use Us.
Posted on Jun 25, 2008
SOURCE: I have a george foreman
Hi mmml,
I'd contact the manufacturer (Salton, Inc.) customer servicesite for replacement parts or manual. If they don't have them, they should knowwhere to send you (though if they don't, I'd seriously wonder about thecompany).
Go to
And click on "George Foreman" (lower-right portion of the page), it redirects you to a secure webpage where you can register.
Part of the page reads:
"Call toll-free or visit our websites for assistance if you need more help.
Parts & Accessories:
Phone: 1-800-738-0245 (Monday–Friday, 8:30 a.m. to 8:00 p.m., ET)
Product Warranty:
Service: 1-800-231-9786 (Monday-Friday, 8:30 a.m. to 8:00 a.m., ET)"
If I can be of further assistance, let me know. If this helps or solves the issue, please rate it accordingly.
Thanks in-advance for using Fixya.com,
Posted on Dec 31, 2008
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
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Posted on Jan 02, 2017
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The Political Question Doctrine
James May
Widener University Delaware Law School
September 20, 2011
PRINCIPLES OF CONSTITUTIONAL ENVIRONMENTAL LAW, p. 217, James May, ed., American Bar Association, 2011
Widener Law School Legal Studies Research Paper No. 11-33
This chapter addresses the extraordinary notion that the Constitution might insulate from federal judicial review some areas of environmental law, including even traditional common law tort causes of action. How? The answer lies in understanding the political question doctrine, under which a federal court concludes that a case is not justiciable because it is somehow textually or prudentially consigned to the elected branches of government. The doctrine's effect makes it particularly important to practitioners and to the very development of the law: A case dismissed under the political question doctrine ends without needing to reach the statutory, common law, or constitutional questions addressed with in this book. Moreover, pleadings, discovery, and motion practice are obviated, and the case is disposed of - merits aside - lock, stock, and barrel. Case closed.
Number of Pages in PDF File: 26
Keywords: political question doctrine, environmental law, constitutional law
JEL Classification: K32
Date posted: September 30, 2011
Suggested Citation
Contact Information


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By Lee Hernandez | 03/24/2011 - 17:37
Real Housewives of Orange County star Tamra Barney told RadarOnline she hopes to walk down the aisle with Eddie Judge, her younger boyfriend of a little over a year. And, contrary to popular belief, he is not friends with her ex-husband, Simon.
Read more
By Lee Hernandez | 12/10/2010 - 16:05
JoAnna Garcia has hit a home run—in her personal life!
The Better With You star—and proud Cubana—is reportedly heading to her homestate of Florida this weekend to tie the knot with her fiancé, New York Yankees outfielder, Nick Swisher.
Read more
By Lee Hernandez | 12/03/2010 - 12:30
It's no secret that Nicole Richie isn't a fan of the paparazzi, and with her top-secret December wedding to fiancé, Joel Madden quickly approaching, Nicole is taking precautions to protect her family from the photogs.
Read more
By Lee Hernandez | 10/10/2010 - 14:30
Spy Kids actress Alexa Vega walked down the aisle today in a Ian Stewart dress and said "I Do" to her fiancé, (producer Sean Covel), a rep for the actress confirms to Latina.com.
Read more
By Monica Herrera | 04/06/2009 - 09:30
Gisele Bündchen and Tom Brady tied the knot for a second time this weekend, throwing a larger wedding celebration at the supermodel's home in Santa Teresa, Costa Rica, for family and friends—but a few uninvited guests were turned away by drastic and violent means.
Read more
By Monica Herrera | 02/24/2009 - 09:33
The cat's out of the bag! Victoria's Secret Angel Adriana Lima eloped with her fiance, NBA player Marko Jaric, on Valentine's Day, tying the knot at an intimate ceremony in Jackson Hole, Wyoming.
Read more
By Monica Herrera | 12/19/2008 - 10:16
Looks like Fergie is finally ready to say "I Do!" The Black Eyed Pea,and Josh Duhamel, her fiancée of just over a year, have set a wedding date for the weekend of January 9-11 and will exchange vows at an undisclosed location in Southern California, a source tells Access Hollywood.
Read more
By Monica Herrera | 12/10/2008 - 14:08
Maybe it's because we're all trained to believe that Jennifer Lopez and Marc Anthony are in a perpetual state of marital bliss, but it took us a full 12 hours to realize that J.Lo left her wedding ring at home when she attended the premiere of Brad Pitt's new movie Monday night. Was it just an innocent mistake?
Read more
By Monica Herrera | 12/09/2008 - 15:58
Gisele Bündchen's already got one New Year's resolution planned out for 2009: get hitched! According to In Touch, the 28-year-old Brazilian supermodel is planning to marry boyfriend and certified football hottie Tom Brady in Costa Rica next year. "There will be no engagement," the magazine's spy dishes. "Just a small wedding in mid-March."
Read more
By Monica Herrera | 12/01/2008 - 10:18
Roselyn Sanchez didn't just celebrate Thanksgiving over the weekend! The Without a Trace star tied the knot with soap actor Eric Winter in a lavish wedding ceremony in Puerto Rico.
Read more
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Why Collins Foods Ltd's share price looks finger-lickin' good value
Australia's listed KFC franchisee, Collins Foods Ltd (ASX: CKF), released its half-yearly results to the market this morning. In addition to decent profit growth, the company also announced it was making its first overseas acquisition, in Germany.
Here's what you need to know:
Revenues rose 4.7% to $282 million
Net Profit After Tax rose 7.8% to $15 million
Earnings per share of 16 cents per share
Interim dividend flat at 8 cents per share
More info on recently announced acquisition of 11 KFC restaurants in Germany
So What?
Most of the growth this half was generated by acquisitions, with Collins noting that…
Australia's listed KFC franchisee, Collins Foods Ltd (ASX: CKF), released its half-yearly results to the market this morning. In addition to decent profit growth, the company also announced it was making its first overseas acquisition, in Germany.
Here's what you need to know:
- Revenues rose 4.7% to $282 million
- Net Profit After Tax rose 7.8% to $15 million
- Earnings per share of 16 cents per share
- Interim dividend flat at 8 cents per share
- More info on recently announced acquisition of 11 KFC restaurants in Germany
So What?
Most of the growth this half was generated by acquisitions, with Collins noting that an increase in the number of restaurants was the primary driver of higher revenues. The KFC franchises have fairly high fixed costs, so Collins must grow sales at existing restaurants or acquire new ones in order to grow further. Domino's Pizza Enterprises Ltd (ASX: DMP) is a good example of how a string of acquisitions combined with rapid organic sales growth can be parlayed into phenomenal success.
As a franchisee of KFC owner Yum! Brands however, Collins Foods is both burdened by franchise fees and also lacks the same ability to innovate its product and service offering that Domino's has.
Collins does have an acquisitive mindset though, and the recent purchase of 11 German KFCs in Stuttgart and Düsseldorf show that the company is now having a crack at expanding overseas. The price of €12.7 million seems a little high, given the stores are generating €22.5 million in sales per annum. If Collins is able to achieve similar net profit after tax margins in these stores as in its Australian ones (just over 5%) that would work out to be a Price to Earnings (P/E) ratio of around 10. Germany has a different tax, regulatory, product sourcing, and wage environment though, so this figure is just for illustration.
Now What?
Collins has a fair amount of debt, and the company has shown no signs of slowing the pace of its acquisitions. This is not a company that would suit every investor, although it is reasonably priced and has a good track record in its operations over the past few years. Collins has also proven quite adept at growing its sales organically. For those comfortable with businesses using debt to grow, Collins could be right up your alley.
An even better bet than Collins Foods, this company's dividend is almost the stuff of legends. Its reliable cash flows support a high payout ratio, and the company's stash of franking credits are the cherry on the top of the dividend cake. Based on the last 12-months of dividends, shares are offering a fully-franked 6.5% yield, which grosses up to a whopping 9.3%, when those franking credits are included.
Discover out the name of this blue chip share along with 2 others in our new FREE report "The Motley Fool's Top 3 Blue Chips Stocks For 2017."
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Motley Fool contributor Sean O'Neill has no position in any stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Bruce Jackson.
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text: Honda Fit Japanese Car of The YearMatt Hardigree11/21/07 9:30am17EditPromoteGo to permalinkThe second-generation Honda Fit may not be Godzilla, but it's at least a Gamera. The beloved little Honda beat out both the Nissan Skyline and Subaru Impreza for the coveted Japanese Car of The Year award. This is quite the turn around from last year, when the large, Mothra-like Lexus LS was given the award.