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The Old Wailuku Inn at Ulupono
Top Romantisches Hotel
ab 208 €
Nice room, cleanly, beach front, nice pool area and not too bad a price for the area...being close to Lahaina was great! The hotel room we stayed in was a bit of a ways from the lobby and we had to walk through a row of shops to get to the front, but towards the end it wasnt that bad being away from commotion. The breakfast was expensive for what was being offered. It wasnt bad, just not worth $30/person. Parking was $18/day which hurt after we were there for so many days.
The view was stunning, and the amenities top notch. That I was unable to stay longer.
I liked the beauty of the resort. All the flowers and the way the pool was designed. Very beautiful grounds. The rooms need to have some upgrades done. Get rid of acustic ceilings old and outdated. The door to the bathroom at the bottom was chipped up and discolored. Moldings in bathroom needed to be recaulked.
Top shelf overall. The beach. Too much coral and rock.
Wish I was still there. I left my camera charger in the room. They shipped it back to me. Loved it and would stay again if I can.
The design of the resort: the pools, the waterfalls, the wildlife lawns, etc. The staff are consistently nice and patient, the shuttle service within Ka'anapoli area, the size of the rooms. Compares to other resorts in the area such as Marriott and Westin, Hyatt's rate is very reasonable about average of $350/night. Son'z restaurant food was terrible for 5-star, fine-dinning categorization. The popcorn ceilings in the rooms can be upgraded. It has no beach - we'd have to walk further the Marriott resort for the beach. Hyatt should do a better job enforcing the no-smoking policy on floors designated as non-smoking floors, it's never pleasant to be out on lanai and having to deal with someone next to your unit smoking up a storm.
Lots of hidden fees. Overpriced food and drinks. They would not give me a complete bill when I checked out. Cost to park my vehicle!
It was a nice $200 a night hotel. Unfortunately I paid $600 a night The valet took 15 minutes to get our car and I had to ask twice to get the car. Two of the three elevators were broken so we eventually carried out bags down 5 flights of stairs after waiting 10 minutes. The bartender used his hands to put ice in people's glasss.
The room, the staff, pool, location Dont think that guests need to pay for sofa or seet on the pool.
room service was awesome...food outstanding. Front desk personnel were very friendly and accommodating. Went to Japengo for dinner...sat us in the lounge area...even though the lanai was ready for seating and to catch the sunset...were told it wasn't open yet although hours of operation stated 5:30...sat with our backs to the water and couldn't see the sunset through the bar...after 10 minutes about 20 Japanese tourists were seated in the restaurant. felt shunned. The floor/carpet was dirty in our room (201). Nasty stains (by the nightstands and throughout the floor) we wore slippahs in the room! Coming from Honolulu, expected more. We were on the second floor and couldn't sit on our lanai since the people next door were out there smoking cigarettes and it smelled disgusting. For $400/night felt ripped off! Also feel parking should be a couple dollars a day...not $16! Then an additional $30 hotel fee???? Hyatt residence club employees were shoving the "timeshare" experience down our throats! Didn't spend that kind of money to try to be persuaded to purchase anything.
* People/service was great! * View of ocean from room was wonderful * always restocked amenities everyday * very clean bathrooms, room, lobby, etc. * Food was very good Everything was overpriced, but we were in Maui, and Hawaii is expensive ... getting there is only the beginning when it comes to spending $$$$
Die Flamingos und Schwäne waren einfach wunderschön. Der Pool war etwas kalt.
1.) Trotz Grösse der Anlage sehr gutes Essen in allen Restaurants (insbesondere "Tropica"). 2.) Gestaltung des Swimmingpool-Bereiches (inkl. Kinder-/Erwachsenenpools, Flamingo-/Koy-Teich, Höhlen etc.) 3.) Freundliche Angestellte. 1. Zimmer: Grösse und Zustand (eine Renovation wäre erforderlich - ein anderer Flügel des Hotels wurde kürzlich renoviert). Sehr kleines Bad. Waschbecken offen (in Küche integriert). 2.) Grösse des Hotels: ergibt ein eher anonymes Hotelerlebnis. Zudem gibt es nicht immer genug Liegestühle für alle Leute. 4) Liegestühle/Sonnenschirme (Anzahl und Preise) 5.) Lift: sehr alte und langsame Liftanlage
The hotel is stunning with amazing ocean views.
Gorgeous property. Rooms are brand-new, very large, well-equipped, extremely well-built and in-room amenities are top notch. Restaurant food was excellent as was seaside dining. Pool area was extremely large and beautifully landscaped. The hotel sits on the windiest part of the island. Most of the week it felt like a gale force wind tunnel thru the middle of the lobby thru to the pool area. We know it was isolated to this location because we visited several wind-free spots on the island throughout the week. There seemed to be a lack of staff (only had poolside attendant one time during the duration of the week). Otherwise, saw no pool waitstaff. The only small thing we didn't like about the room itself was that there was only one mirror in the whole condo (in the bathroom). It would be great if there was a mirror in the bedroom so you can get dressed with out having to go back to the bathroom especially when sharing the suite with more than one other person.
Cleanliness, modern kitchen, ocean view, beautiful pools. Low thread-count sheets on bed were scratchy.
My wife and I had a great time relaxing by the pool drinking wonderful lava flows! Price was a little expensive.
Everything was new and pretty. I liked that kitchen was well furnishined and the room design was nice. We got complimentary sparkling wine since we were honeymooner. The worst thing about the hotel was that it was very short of people. Our first room did not have enough hot water for one person to finish the shower. But it took about 3 hours for them to get us into another room. We tried to get help from bell boy to move our luggages but they told us that we need to wait for 5 minutes. We moved by ourselves. Any time I tried to get help from front desk and it took them while to respond. Also I won't blame it to the hotel but it was so windy all the time. It was like we were in middle of storm all evening through out the time of our stay. Our martini glass had a chewing gum stuck to it.
It was a very comfortable brand-new condominium with well-appointed equipments, full kitchen, Washer& Dryer, full-open glass door to the balcony. The Deli has not enough selection of goods and foods. It was unsatisfactory room cleaning for a couple of day.
Great hotel, great location
Exzellente Lage am Strand. Schöne Pool-Anlage. Schöne Sicht aufs Meer vom Zimmer. Kein netter Service (wenig hilfsbereit, wenig herzlich, bitte nichts verlangen, was nicht ausdrücklich schriftlich zugesagt wurde, Gefängnisatmosphäre, Leute am Pool sind mit Armband als Hotelgäste gekennzeichnet etc. Gar nicht hang-loose Stil, Das Logo müsste sein: Bitte keine Extra-Würste...
Einfach super, beste Lage.
location - windy and rainy part of the island
There is simply no better location in Maui Activity concierge was not really ahead of its game
Amazing service! Perfect for our honeymoon with exceptional service, great location, beautiful ocean front grounds.
Friendliness of staff, club floor with lounge access, quality of food, comfort of room, ultr cleanliness of room, luxury of hotel
Stephen the valet set the tone from the moment he opened my wife's car door, escorted us to check-in, and down to our pool terrace room. His courtesy and hospitable attitude was echoed by the front desk, concierge, restaurant and housekeeping staff. Comfortable King bed room included a chaise lounge, desk, bench at foot of bed, huge LED TV and spa bath. In room coffee/tea and fridge for our own snacks/drinks. Clean clean clean. Excellence and luxury throughout. Amazing shore, pool areas, walking trails... Peaceful location above the fray of the more populated costal areas -- but only about a 15-minute ride to Lahaina with its lively stores, restaurants, and harbor activities, We know where we will be staying on Maui. Bravo! Nada!
The space, the unnoticeable but well prepared luxury and services. Cleanness, location,choice of programs, overall hospitality.
It was a great experience staying such cozy resort with excellent restaurants and location. N/A
Large well-appointed rooms...gorgeous beach. Concierge team was excellent, especially Shelly.
very nice room, well maintained and handsome grounds, friendly and efficient staff, beach access good, nearby snorkeling good. very long walk to hotel room. Although minor, but had coffee (latte) in hotel. Ouch- was bitter- i suspect very inferior beans that were also over roasted. I disliked the coffee so much that I didn't eat or drink anything in the hotel. I rather went to all the other nice restaurants nearby.
Clean and uodated facilities and room. Excellent customer service and attention to detail. The grounds and gardens are beautiful. The on site seaside cliff is spectacular. Beach area was nice and secluded but small.
The location of the property is beautiful. The service left a lot to be desired -- not what you would expect from the Ritz-Carleton. In fact, we were so disappointed, we checked out after two nights and moved to a different hotel.
Food was excellent.
die Strandlage, die Abendbar am Swimmingpool sowie das Zimmer waren o.k. Das Hotel fand ich als 3 Sterne Hotel überteuert
Sehr gute Lage, sehr gepflegter Strand, glasklares Wasser, große, sehr gepflegte Hotelanlage Der Check-in bzw. Check-out könnte von der Zeit her flexibler sein.
Hawaiian Atmosphäre Die Betten waren nicht so toll
Sehr freundliches Personal, wunderschöne tropische Parkanlage, 4 weitere Top Restaurants in der Nähe, Frühstücksbuffet,
Wir waren sehr zufrieden mit dem Hotelangebot. Nicht gefallen hat uns : 11min telefon nach Deutschland 85 USD !!!Das ist Wucher !!!
Die schöne Hotelanlage mit Park und Strand hat mir sehr gut gefallen. Auch ist die Lage des Hotels optimal. Im grossen und ganzen muss das Hotel renoviert werden, v.a die Badezimmer. In der Dusche war Schimmelpilz überall. Wir haben das Zimmer gewechselt weil dies einfach unzumutbar war. Nach Besichtigung von 3 weiteren Zimmern sind wir zum Schluss gekommen, dass die ein generelles Problem in diesem Hotel ist, da alle Badezimmer mit Schimmelpilz befallen waren was eigentlich logisch ist, da es kein Abluftsystem gibt. Auch wurde das Badezimmer nicht gereinigt sondern nur die Tücher gewechselt. Ich würde nie wieder hier übernachten.
wunderschöner Strand, sauberes Wasser und die grosszügige Gartenanlage (Liegewiese) mit genug Schattenplätze und Liegestühlen Zimmer dringend renovierungsbedürftig! Ungemütlich feuchte und muffige Luft im Zimmer. Ungenügendes einseitiges Angebot in Verpflegung zur Lunchzeit. (Nur Fastfood bei Tikigrill)
Schöne Aussicht auf den Strand, schöne Terrasse, mehr Privatsphäre, tägliche Reinigungsdienstleistungen, schön Schränke. Alles in allem ein schöner Ort zum übernachten. Günstig im Vergleich zu anderen Hotels. Es sollte modernisiert werden.
Gute Lage wenn man mit einem Mietwagen unterwegs ist. Klimaanlage war unterdimensioniert für die Zimmergröße, vor allem da das Zimmer direkt unter dem Flachdach gelegen ist.
Das Hotel ist sehr alt und hat einen leichten Schimmelgeruch. Das Parken ist schrecklich. Das Personal war sehr nett. Wir verbrachten unsere letzte Nacht in der Nähe des Flughafens. Ich würde nicht wieder hier übernachten.
Super Pool direkt am Meer Hotel liegt nahe Flughfen aber kein Fluglärm zu hören ist gut zu finden Shopping near by
Gute zentrale Lage direkt am Meer
Bei Vorbuchung unkompliziert in der Abwicklung. Zimmer sind in Ordnung, nur Preis Leistung ist ein wenig hoch. Das anschließende Restaurant welches Frühstück anbietet könnte preisgünstiger sein.
Das Zimmer war sehr altmodisch. Nicht sehr sauber
Gut gelegener Standort für Ausflüge
ruhiges und geräumiges Zimmer mit Balkon, Hotellage nur wegen der Flughafennähe zu empfehlen. Sauberer, aber langweiliger Strand direkt neben dem Container-Hafen, unruhig wegen der vielen LKWs, die rückwärts einladen, dadurch die lästigen und lauten typisch amerikanischen Piepgeräusche.
Makelloser Platzwart, super sauber, sehr freundliches Personal und überragender Kundenservice.
Es war zu unserer zufreidenheit
wenig das Zimmer war nicht wirklich sauber, Boden immer voller Sand, Türen schlossen schlecht, Servicepersonal teilweise nicht sehr freundlich, meine Buchung wurde erst anch 15 Minuten gefunden und ich wurde ziemlich unfreundlich behandelt. Würde ich so nicht nochmal empfehlen und buchen, war dafür dann doch zu teuer...
Our one bedroom unit worked well. We ate in or out as suited us. Nice 3.5 mile beach trail starts in a park just south of the property; good for running and walking, but could be contested in spots. we had full access to the timeshare immediately south, and frequented the happy hour at their beach/pool bar and their lounge chairs. Grounds were lush and attractive. Beach was nice to look at, but not very useable, as it was small and the surf was high. Too small even for lounging. Next door was better.
Huge room. Gorgeous views. Huge tub. Beautiful tile work. Big kitchen. Washer and dryer The beds were just awful. They were rock hard and not comfy at all. The pillows were small. Had a very hard time sleeping. No coffee maker!!!
This place had everything that we expected and the Beach was great you could go rite from your hotel snorkeling I recommend this place a return Everything
Price and upgade
The view and the pools are very nice and I was impressed with them. The food and drinks were just average. I understand that more people cook themselves in this type of property and not to expect a five star experience. The service was weak and inattentive in the restaurant, enough to get you your meal, but mostly feeling in different.
The entire resort was really well maintained, had an amazing view of the ocean, liked the fact that the patios were huge. Really close proximity to the beach. Convenient store inside the resort was very useful and had good breakfast. Even though the resort itself was really well maintained, the unit itself was outdated and had issues like the TV remote did not work, patio door was broken and hard to open and close. Kitchen was very outdated as well.
The 1 bedroom condo units are very spacious and well-designed. You feel like you're living at the beach rather than escaping your room for outings. We did not hear any noise from nearby units except when the maids were moving patio furniture to clean. Our unit could have used a larger living room TV (approx. 25in CRT) as it was dark by 6pm and we just wanted to watch a movie at night. (TV size varies with the individually-owned units.) It was particularly nice to have a washer & dryer in the unit.
I liked the location, the comfort and spaciousness of our room, and could appreciate the efforts beiing made by the property to upgrade its facilities. I did not like the fact that we were not informed prior to arrival that construction was going on. To be fair, the hotel reduced our rate after I complained.
Beautiful accommodations, great location with amazing beachfront access. The condo units are very well stocked with supplies.
Friendly staff. Everything exceeded our expectation
The moment we walked into our condo and saw the view, we fell in love with the place. The ocean view with the neighboring islands were amazing. We saw a sea turtle grazing on some seaweed just a few feet from our lounge chairs. We also saw a whale breaching and splashing around from our balcony. The interior was very nice and well kept. The appliances were new, the countertops were recently upgraded from the looks of it. They had everything that you needed to make yourself comfortable in the condo. We never needed to get anything else except food when we were there. It's also very affordable compared to other places. The only thing we can criticize was the size of our bed. They only had a full size mattress and I felt a bit cramped with me being 6 ft and my wife in the small bed. Other than that small detail, the place was just fantastic.
staff were friendly and accommodating. veryhelpful. Liked that shuttle took you around. not so scenic near airport
Location near airport. Inside the hotel it was cool but just as humid as outside. Clothes never really dried out.
All aspects of the Marriott were amazing-clean, friendly, professional and truly made us feel like guests. We couldn't believe the size of the lawn!
- 9 out of 10 of the staff members were enthusiastic, extremely helpful, and friendly. - The rooms were well designed and well decorated - The free shuttle rides for anywhere within three miles of the hotel was wonderful. - proximity to airport - The bistro appeared to more like a local starbucks than a place for guests to relax. Quite a few non-guest meetings/gatherings were taking place - particular staff members appeared to be a bit cold and "going through the motions" of hospitality. Not as warm and welcoming as the other staff members. But the warmth of everyone else was WAY more noticeable. - The distance from popular attractions makes this hotel just an overnight stay location for travelers


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Hotels near Eco'parc Mougins
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"Friendly staff who were happy to speak to us in English or French. Rooms always cleaned very well, decent sized pool. Great location too, as a bus stop is at the top of the road and goes straight to Cannes. This is the best way to experience France as you get to see more than just the beach. I wi..."
A Traveller, Aug 2015, GB
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"Expensive but charming boutique hotel with beautiful grounds and friendly staff. Rooms have small terraces with table and 2 chairs to enjoy the outside. Poolside dining reasonable, but gourmet dinner dining very costly. While hotel has continental breakfast for approx. 22 Euros, went to 1 of 2..."
A Traveller, Aug 2016, US
16 people looked at this hotel in the last hour
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"Nice little place close to cannes downtown ifu have a car; otherwise not sure how to get around... there is a nice pool and standard breakfast ... decent price and clean. A little old and confising how to open/close door.. and ofcourse without french its hard to communicate.. overall it was good"
A Traveller, Jul 2014, US
15 people looked at this hotel in the last hour
14 people looked at this hotel in the last hour
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"Very helpful staff.at reception and drivers of the hotel shuttle and housekeeping girl.hotel has very nice facilities.nice clean rooms and sitting areas and swimming pool.shuttle yo croisette was very handy at the time of the festival.overall great setvice and no complaints.felt safe in the area ..."
A Traveller, May 2015, GB
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13 people looked at this hotel in the last hour
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"stayed at hotel for wedding that we were attending nearby"
A Traveller, Aug 2016, GB
12 people looked at this hotel in the last hour
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"A good hotel but can be noisy with early morning deliveries. Rooms at the front are better. A 20 minute direct walk to the beach at Cannes makes this a great place to stay. Reception are very helpful and speak several languages. Street parking is free. I would stay again."
A Traveller, Aug 2016, GB
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Prep Time: 5 minutes | Cook Time: 55 minutes
pie crust on large foil-lined baking sheet. Mix pumpkin, milk, eggs and pumpkin pie spice in large bowl until smooth. Pour into crust.
in preheated 425°F oven 15 minutes. Reduce oven temperature to 350°F.
40 minutes longer or until knife inserted 1 inch from crust comes out clean. Cool completely on wire rack. Serve with Vanilla Whipped Cream.
Makes 8 servings.
Vanilla Whipped Cream: Beat 1 cup heavy cream, ¼ cup confectioners' sugar and 1 tsp. McCormick® Pure Vanilla Extract in medium bowl with electric mixer on high speed until stiff peaks form.


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Alternative websites for 411seniors.bc.ca
1. Result for 411seniors.bc.ca
Home · About Us · Contact Us · Programs and Activities · Weekly Schedule · Resources. OSC header. profile. announcement · events · menu · trips ...
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Jun 13, 2014 ... Find opportunities for seniors to get involved and stay active through local community centres.
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Listing of Senior Centres in British Columbia, Canada. Includes addresses, phone numbers, hours and activities.
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Classic Caban Jacket
389,95 € 199,95 €
- The classic!
- Caban jacket lined with twill
- Buttons in horn look and double button row closure
- Large collar and lapels
- Slightly flared hem
- Straight cut
- 80% fleece wool
- 20% nylon
- Semi-fitted coat
- Length: 85
Model is 178cm / 5'10" and is wearing an UK size 8
- Do not wash
- Do not bleach
- Iron at max.temperature 110°
- P- dry cleaning mild process
- Do not tumble dry
Shipping costs
Within Germany we will take care of the costs for careful packaging and reliable delivery of goods.
See details about shipping costs abroad
Delivery period
In general, you will receive your order within 1-3 business days.
You may return the goods without giving reasons within 2 weeks by returning the goods.View returns details


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Pet Sitter in Jensen Beach
I live in Jensen Beach Florida dog person I have currently have a job at crawdaddies working as a dishwasher and I'm very people person my contact number is 772-626-...
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Another novice question:
In clearing the TB bed I've found several rhizomes that during the hard
rains of winter seem to have burrowed down into the neat ridges I carefully
planted them atop, so as to leave the rhizome exposed (as we are counseled
to do here in humid Ark). Now the whole foot of the rhizome is under dirt,
which worries me since I've already got soft rot on NIGHT AFFAIR.
Is it OK for me to dig these fellows now and reset them (maybe atop a
half-inch or so of sand). Do I need to wait until summer or fall? What if
they get sick before then?
email@example.com USDA Zone 7b
Little Rock, Arkansas
49+ inches rain per year
average relative humidIty at 6am year-round: 84%
more than 200 frost-free growing days


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urbtech xaviers @8010201303 we are inform to you urbtech india bring urbtech xaviers new project come to sector 168 noida. urbtech xaviers offer studio apartment and one two three four bhk flats in N… Read more
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19 items
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Tirunelveli (Tamil Nadu), Mar 20 : Twelve people were injured when everal coaches of the Madurai-Kollam passenger train derailed between alliyur and Aralvaimozhi near here early this morning.
Senior railway officials from Madurai have gone to the spot of the mishap nd are overseeing rescue and relief operations.
An investigation has been ordered to ascertain the exact cause of the erailment.


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Top Definition
a wolf person that is really protective of stuff
Rennix is just a simple name for werewolf
like......jacob black is a rennix
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Research Topics
Genomes and Genes
Gene Symbol: BSCL2
Description: Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Alias: GNG3LG, HMN5, PELD, SPG17, Bernardinelli-Seip congenital lipodystrophy type 2 protein
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications119 found, 100 shown here
- Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effectsMao Fu
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 89:2916-22. 2004Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder caused by mutations in AGPAT2 and Gng3lg. We screened for mutations in AGPAT2 and Gng3lg in 26 families with CGL and one family with Brunzell syndrome...
- The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphologyKimberly M Szymanski
Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:20890-5. 2007..most severe inherited form is Berardinelli-Seip Congenital Lipodystrophy Type 2, associated with mutations in the BSCL2 gene. BSCL2 encodes seipin, the function of which has been entirely unknown...
- A novel 16p locus associated with BSCL2 hereditary motor neuronopathy: a genetic modifier?Esther Brusse
Department of Neurology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Neurogenetics 10:289-97. 2009..N88S) in BCLS2 (11q12-q14). All 12 affected relatives had the BSCL2 mutation and the chromosome 16p haplotype and showed features of motor neuron degeneration...
- N88S mutation in the BSCL2 gene in a Serbian family with distal hereditary motor neuropathy type V or Silver syndromeV Rakocevic-Stojanovic
Institute of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, 6, Dr Subotica Street, 11000 Belgrade, Serbia
J Neurol Sci 296:107-9. 2010Distal hereditary motor neuropathy type V (dHMN-V) and Silver syndrome are rare phenotypically overlapping diseases which can be caused by mutations in the Berardinelli-Seip Congenital Lipodystrophy 2 (BSCL2) gene or Seipin.
- Clinical and histopathological study of Charcot-Marie-Tooth neuropathy with a novel S90W mutation in BSCL2B O Choi
Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea
Neurogenetics 14:35-42. 2013..S90W mutation in the Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) gene, after filtering 31 Korean control exomes. Our p...
- Novel mutations of the BSCL2 and AGPAT2 genes in 10 families with Berardinelli-Seip congenital generalized lipodystrophy syndromeDebora M Miranda
Department of Paediatrics, Universidade Federal de Minas Gerais, Avenue Antonio Carlos 6627, Belo Horizonte, Brazil
Clin Endocrinol (Oxf) 71:512-7. 2009..or Berardinelli-Seip syndrome, is a rare autosomal recessive disease caused by mutations in either the BSCL2 or AGPAT2 genes...
- Congenital generalized lipodystrophy in an Indian patient with a novel mutation in BSCL2 geneH U Shirwalkar
Department of Molecular Endocrinology, National Institute for Research in Reproductive Health ICMR, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India
J Inherit Metab Dis 31:S317-22. 2008..Mutations in BSCL2 are known to be associated with a severe form of CGL and mental retardation (MR)...
- The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiationWeiqin Chen
Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Diabetes and Endocrinology Research Center, Houston, Texas 77030, USA
Endocrinology 150:4552-61. 2009Mutations in the Berardinelli-Seip congenital lipodystrophy 2 gene (BSCL2) are the underlying defect in patients with congenital generalized lipodystrophy type 2. BSCL2 encodes a protein called seipin, whose function is largely unknown...
- Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese: a novel homozygous nonsense mutation in seipin geneKen Ebihara
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
J Clin Endocrinol Metab 89:2360-4. 2004..We did not find any AGPAT2 mutations in our Japanese patients, suggesting that AGPAT2 is a minor causative gene, if any, for CGL in Japanese. This is the first report on gene and phenotype analysis of CGL in Japanese...
- Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17Daisuke Ito
Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Neurobiol Dis 31:266-77. 2008Seipin, which is encoded by the BSCL2 gene, is a glycoprotein of unknown biochemical function that is associated with dominant hereditary motor neuron diseases...
- Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genesVinaya Simha
Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Endocrinol Metab 88:5433-7. 2003..We conclude that CGL patients with Seipin mutations have a more severe lack of body fat, which affects both metabolically active and mechanical adipose tissue, compared with patients with mutations in the AGPAT2 gene...
- Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesisWeihua Fei
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
J Lipid Res 52:2136-47. 2011..Our results provide important insights into the biochemical characteristics of seipin and its mis-sense mutants, and suggest that seipin may function to inhibit lipogenesis...
- Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophyEmilie Boutet
INSERM, UMR, CdR Saint Antoine, Paris, France
Biochimie 91:796-803. 2009..These findings provide new insights into how seipin deficiency causes severe lipodystrophy...
- Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeastWeihua Fei
Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
J Cell Biol 180:473-82. 2008..These results suggest that an evolutionally conserved function of seipin in phospholipid metabolism and LD formation may be functionally important in human adipogenesis...
- The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiationVictoria A Payne
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
Diabetes 57:2055-60. 2008Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder featuring near complete absence of adipose tissue...
- Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndromeChristian Windpassinger
Institute of Medical Biology and Human Genetics, Medical University Graz, Harrachgasse 21 8, A 8010 Graz, Austria
Nat Genet 36:271-6. 2004..After refining the critical region to 1 Mb, we sequenced the gene Berardinelli-Seip congenital lipodystrophy (BSCL2) and identified two heterozygous missense mutations resulting in the amino acid substitutions N88S and S90L...
- N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stressTakuya Yagi
Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
Hum Mol Genet 20:3831-40. 2011Heterozygosity for mutations (N88S and P90L) in the N-glycosylation site of seipin/BSCL2 is associated with the autosomal dominant motor neuron diseases, spastic paraplegia 17 and distal hereditary motor neuropathy type V, referred to as ..
- Phenotypes of the N88S Berardinelli-Seip congenital lipodystrophy 2 mutationMichaela Auer-Grumbach
Institute of Medical Biology and Human Genetics, Medical University Graz, Harachgasse 21 8, A 08010 Graz, Austria
Ann Neurol 57:415-24. 2005..Sensory nerve conduction studies were rarely pathological. Our study indicates that the dominant N88S mutation in the Berardinelli-Seip congenital lipodystrophy gene 2 leads to a broad spectrum of motor neuron disorders...
- Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13J Magre
INSERM U 402, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27 rue Chaligny, 75012 Paris, France
Nat Genet 28:365-70. 2001..mutations in a gene homologous to the murine guanine nucleotide-binding protein (G protein), gamma3-linked gene (Gng3lg) in all BSCL2-linked families...
- Two Japanese infants with congenital generalized lipodystrophy due to BSCL2 mutationsAtsushi Nishiyama
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
Pediatr Int 51:775-9. 2009..Recently, two genes, BSCL2 and AGPAT2, were identified as causative genes for CGL...
- Molecular pathogenesis of seipin/BSCL2-related motor neuron diseasesDaisuke Ito
Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
Ann Neurol 61:237-50. 2007Heterozygous mutations in the Seipin/BSCL2 gene have recently been identified in two autosomal dominant motor neuron diseases, distal hereditary motor neuropathy type V and Silver's syndrome...
- Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patientsK B Gomes
School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
J Inherit Metab Dis 28:1123-31. 2005..pedigrees living in the northeastern region of Brazil had a homozygous 669insA mutation in the Seipin gene (BSCL2 locus), while all of the 10 investigated subjects from the southeastern region were homozygous for a 1036 bp ..
- Seipin S90L mutation in an Italian family with CMT2/dHMN and pyramidal signsM Luigetti
Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy
Muscle Nerve 42:448-51. 2010Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been associated with different clinical phenotypes including Silver syndrome/spastic paraplegia 17, distal hereditary motor neuropathy type V, and ..
- Identification of de novo BSCL2 Ser90Leu mutation in a Korean family with Silver syndrome and distal hereditary motor neuropathyHyun Jung Cho
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul, 135 710 Korea
Muscle Nerve 36:384-6. 2007Mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been identified in families with distal hereditary motor neuropathy (dHMN) and in families with SPG17-linked Silver syndrome...
- The Silver syndrome variant of hereditary spastic paraplegia maps to chromosome 11q12-q14, with evidence for genetic heterogeneity within this subtypeH Patel
Medical Genetics, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, United Kingdom
Am J Hum Genet 69:209-15. 2001..one large multigenerational family, which revealed evidence for linkage of the SS locus, which we have designated "SPG17," to chromosome 11q12-q14...
- BSCL2 mutations in two Dutch families with overlapping Silver syndrome-distal hereditary motor neuropathyBart P C van de Warrenburg
Department of Neurology, Radboud University Nijmegen Medical Centre, 326, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Neuromuscul Disord 16:122-5. 2006Mutations in the BSCL2 gene have recently been identified in families with (SPG17-linked) Silver syndrome-type hereditary spastic paraparesis as well as in families with distal hereditary motor neuropathy (HMN)...
- The first Italian family with evidence of pyramidal impairment as phenotypic manifestation of Silver syndrome BSCL2 gene mutationGianfranco Cafforio
Department of Neuroscience O U of Neurology, S Chiara Hospital, University of Pisa, Pisa, Italy
Neurol Sci 29:189-91. 2008Silver syndrome (SPG17) is a rare form of hereditary spastic paraparesis...
- Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophyVinaya Simha
Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Endocrinol Metab 88:2821-4. 2003..e. AGPAT2, Seipin, and PPARG also revealed no substantial alterations. We conclude that MAD is a genetically and phenotypically heterogeneous disorder. Besides LMNA gene, other as yet unmapped loci could be linked to MAD...
- Human lipodystrophies: genetic and acquired diseases of adipose tissueJacqueline Capeau
INSERM, U938, CdR Saint Antoine, Paris, France
Endocr Dev 19:1-20. 2010..Treatment of fat redistribution can sometimes benefit from plastic surgery. Lipid and glucose alterations are difficult to control leading to early occurrence of diabetic, cardiovascular and hepatic complications...
- A novel candidate locus on chromosome 11p14.1-p11.2 for autosomal dominant hereditary spastic paraplegiaGuo Hua Zhao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Chin Med J (Engl) 121:430-4. 2008..Thirteen loci for autosomal dominant HSP have been mapped...
- [Major insulin resistance syndromes: clinical and physiopathological aspects]C Vigouroux
Unité INSERM 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris
J Soc Biol 195:249-57. 2001....
- Seipin: from human disease to molecular mechanismBethany R Cartwright
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
J Lipid Res 53:1042-55. 2012The most-severe form of congenital generalized lipodystrophy (CGL) is caused by mutations in BSCL2/seipin...
- Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generationHua Dong Fan
1 School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China 2 Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences and Anhui Province, Hefei 230031, China
Acta Pharmacol Sin 36:497-506. 2015..The aim of this study was to investigate the effects of mutant seipin on autophagy system and the morphology of lipid droplets in vitro...
- Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animalsHongyi Zhou
Department of Physiology, Georgia Regents University, Augusta, GA 30912
J Lipid Res 56:1912-25. 2015Mutations in BSCL2/SEIPIN cause Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), but the mechanisms whereby Bscl2 regulates adipose tissue function are unclear...
- Analyzing the functions and structure of the human lipodystrophy protein seipinM F Michelle Sim
Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, United Kingdom
Methods Enzymol 537:161-75. 2014Disruption of the gene BSCL2, which encodes the protein seipin, causes severe generalized lipodystrophy in humans with a near complete absence of adipose tissue...
- Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesisChihiro Ebihara
Department of Medicine and Clinical Science
Hum Mol Genet 24:4238-49. 2015Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL)...
- Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16Chao Wen Wang
Institute of Plant and Microbial Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan
J Cell Sci 127:1214-28. 2014..We propose that human seipin might adopt the architecture of the yeast Fld1-Ldb16 complex in order to properly maintain the size of LDs...
- Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeastHeimo Wolinski
Institute of Molecular Biosciences, BioTechMed Graz, University of Graz, Austria Electronic address
Biochim Biophys Acta 1851:1450-64. 2015..We suggest that the formation of SLD is a consequence of locally altered PL metabolism at this site. ..
- [Congenital generalized lipodystrophy: a case report with neurological involvement]H Ben Turkia
Service de Pediatrie, Hopital La Rabta, Jebbari, Tunis, Tunisie
Arch Pediatr 16:27-31. 2009..Peripheral hypertonia and reflex excitability revealed signal abnormalities in white matter on magnetic resonance imagery, which has not been described previously in the literature...
- [Genetics of congenital lipodystrophies]A Buffet
Service d endocrinologie, Nutrition et Maladies Metaboliques, CHU Larrey, 24 chemin de Pouvourville, TSA 30030, 31059 Toulouse, France Electronic address
Ann Endocrinol (Paris) 76:S2-9. 2015..Mutations in 15 predisposition genes are currently described; BSCL2 and AGPT2 genes are the major genes in the generalized forms...
- Role of seipin in lipid droplet morphology and hepatitis C virus life cycleSophie Clement
Division of Clinical Pathology, University Hospital, University of Geneva School of Medicine, Geneva, Switzerland
J Gen Virol 94:2208-14. 2013..These results suggest that the available outer surface of lipid droplets is a critical factor for HCV release, independent of the neutral lipid content of the cell. ..
- Genetic disorders of adipose tissue development, differentiation, and deathAnil K Agarwal
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9052, USA
Annu Rev Genomics Hum Genet 7:175-99. 2006..of triglyceride and phospholipids), AKT2 (encoding a protein involved in insulin signal transduction), and BSCL2 (encoding seipin, whose role in the adipocyte biology remains unclear)...
- Exome sequencing circumvents missing clinical data and identifies a BSCL2 mutation in congenital lipodystrophyJens Schuster
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala, Sweden
BMC Med Genet 15:71. 2014....
- Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutationsSavitha Shastry
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Am J Med Genet A 152:2245-53. 2010..Three CGL loci, AGPAT2, BSCL2, and CAV1, have been identified previously...
- Motor neuropathy-associated mutation impairs Seipin functions in neurotransmissionShunhui Wei
Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A STAR, Singapore
J Neurochem 129:328-38. 2014..These data demonstrate that Seipin-N88S mutation impairs synaptic neurotransmission, possibly by regulating the priming and docking of synaptic vesicles at the synapse...
- A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegiaThomas T Warner
Dept of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
J Neurol 251:1068-74. 2004..We have previously described a large kindred with SS and mapped a genetic locus (SPG17) to chromosome 11q12-q14...
- BSCL2 S90L mutation in a Chinese family with Silver syndrome with a review of the literatureZhidong Cen
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, PR China
J Clin Neurosci 22:429-30. 2015..Most reported patients (21 of 26) with this mutation showed a phenotype of Silver syndrome. The S90L mutation is predominantly associated with Silver syndrome. ..
- Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiationWeiqin Chen
Address correspondence to Lawrence Chan
Mol Cell Biol 32:1099-111. 2012Mutations in BSCL2 underlie human congenital generalized lipodystrophy. We inactivated Bscl2 in mice to examine the mechanisms whereby absence of Bscl2 leads to adipose tissue loss and metabolic disorders...
- Seipin: a mysterious proteinAnil K Agarwal
Division of Nutrition and Metabolic Diseases, the Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Trends Mol Med 10:440-4. 2004
- A new seipin-associated neurodegenerative syndromeEncarna Guillen-Navarro
Unit of Medical Genetics and Dysmorphology, Division of Pediatrics, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
J Med Genet 50:401-9. 2013Seipin/BSCL2 mutations can cause type 2 congenital generalised lipodystrophy (BSCL) or dominant motor neurone diseases. Type 2 BSCL is frequently associated with some degree of intellectual impairment, but not to fatal neurodegeneration...
- Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2(-/-) female mice with lipodystrophyRong Li
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA Electronic address
Reprod Toxicol 54:76-83. 2015Berardinelli-Seip congenital lipodystrophy 2-deficient (Bscl2(-/-)) mice recapitulate human BSCL2 disease with lipodystrophy. Bscl2-encoded seipin is detected in adipocytes and epithelium of mammary gland...
- How to diagnose a lipodystrophy syndromeMarie Christine Vantyghem
INSERM U859, Service d Endocrinologie et Maladies Métaboliques, Hopital Huriez, CHRU de Lille, 1, rue Polonovski, 59000 Lille, France
Ann Endocrinol (Paris) 73:170-89. 2012..Other therapeutic options will undoubtedly be developed, dependent on pathophysiological advances, which today tend to classify genetically determined lipodystrophy as being related to laminopathy or to lipid droplet disorders...
- Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiencyBarbara Antuna-Puente
Institut National de la Sante et de la Recherche Medicale, Unité 938, University Pierre and Marie Curie, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, 27 rue Chaligny, 75012 Paris France
J Clin Endocrinol Metab 95:1463-8. 2010..The mechanisms linking fat loss to severe insulin resistance remain unclear. Adipokines may have important roles as intermediary players in metabolism...
- Thin corpus callosum and amyotrophy in spastic paraplegia--case report and review of literatureBeate Winner
Department of Neurology, University of Regensburg, Regensburg, Germany
Clin Neurol Neurosurg 108:692-8. 2006..Sequence analysis did not reveal disease causing mutations in the genes SLC12A6 (Andermann), Spastin (SPG 4), BSCL2 (SPG 17) and Spartin (SPG 20)...
- [Seipin/BSCL2-related motor neuron disease: Seipinopathy is a novel conformational disease associated with endoplasmic reticulum stress]Daisuke Ito
Department of Neurology, School of Medicine, Keio University
Rinsho Shinkeigaku 47:329-35. 2007In 2004, heterozygous mutations (N88S, S90L) in the Seipin/BSCL2 gene were identified in two autosomal dominant motor neuron diseases, distal hereditary motor neuropathy type V (OMIM #182960) and Silver syndrome (OMIM #270685)...
- Description of an AGPAT2 pathologic allelic variant in a 54-year-old Caucasian woman with Berardinelli-Seip syndromeCaterina Pelosini
Department of Endocrinology and Kidney, University Hospital of Pisa, Italy
Acta Diabetol 48:243-6. 2011..syndrome, the sequences of AGPAT2 (encoding for 1-acyl-sn-glycerol-3-phosphate acyltransferase beta) and BSCL2 (encoding for seipin) candidate genes were analyzed...
- Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanismsM F Michelle Sim
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
Diabetologia 56:2498-506. 2013In humans, disruption of the gene BSCL2, encoding the protein seipin, causes congenital generalised lipodystrophy (CGL) with severe insulin resistance and dyslipidaemia...
- BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodellingWulin Yang
Singapore Bioimaging Consortium
Hum Mol Genet 23:502-13. 2014..Finally, 3T3-L1 cells expressing a severing-resistant actin mutant exhibited impaired adipogenesis. We propose that seipin regulates adipogenesis by recruiting cofilin-1 to remodel actin cytoskeleton through the 14-3-3β protein...
- Alleviation of seipinopathy-related ER stress by triglyceride storageMaarit Hölttä-Vuori
Institute of Biomedicine, Anatomy, University of Helsinki, 00014 Helsinki, Finland
Hum Mol Genet 22:1157-66. 2013Mutations affecting the N-glycosylation site in Berardinelli-Seip lipodystrophy (BSCL)-associated gene BSCL2/seipin lead to a dominantly inherited spastic paraplegia termed seipinopathy...
- Altered lipid metabolism in residual white adipose tissues of Bscl2 deficient miceWeiqin Chen
Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, United States of America
PLoS ONE 8:e82526. 2013Mutations in BSCL2 underlie human congenital generalized lipodystrophy type 2 disease. We previously reported that Bscl2 (-/-) mice develop lipodystrophy of white adipose tissue (WAT) due to unbridled lipolysis...
- A high-throughput resequencing microarray for autosomal dominant spastic paraplegia genesClaudia Dufke
Department of Medical Genetics, Eberhard Karls University, Tubingen, Germany
Neurogenetics 13:215-27. 2012..with autosomal dominant HSP and 40 positive controls with known mutations in ATL1, SPAST, NIPA1, KIF5A, and BSCL2 (32 base exchanges, eight small indels) were resequenced on this array...
- The phenotype of motor neuropathies associated with BSCL2 mutations is broader than Silver syndrome and distal HMN type VJoy Irobi
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
Brain 127:2124-30. 2004..We recently found heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2, seipin) gene causing SPG17 and distal hereditary motor neuropathy type V (distal HMN V)...
- Clinical review#: Lipodystrophies: genetic and acquired body fat disordersAbhimanyu Garg
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8537, USA
J Clin Endocrinol Metab 96:3313-25. 2011..The extent of fat loss determines the severity of associated metabolic complications such as diabetes mellitus, hypertriglyceridemia, and hepatic steatosis...
- Kinetics of zinc status and zinc deficiency in Berardinelli-Seip syndromeMaria Goretti Do Nascimento Santos
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte UFRN, Natal, Brazil
J Trace Elem Med Biol 26:7-12. 2012..It is caused by mutations in AGPAT2 or Gng3lg. We evaluated 10 BSS patients and 10 healthy subjects. A single dose of 382...
- Seipin ablation in mice results in severe generalized lipodystrophyXin Cui
Institute of Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, People s Republic of China
Hum Mol Genet 20:3022-30. 2011Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterized by an almost complete loss of adipose tissue, insulin resistance and fatty liver...
- Phenotypic heterogeneity in hereditary motor neuropathy type V: a new case report seriesManuela Pennisi
Biochemistry and Molecular Biology Section, Department of Chemistry, University of Catania, Catania, Italy
Acta Neurol Belg 112:57-64. 2012..This broad phenotypic and genotypic spectrum calls the clinician attention to this rare and still insufficiently known disease...
- [Lipoatrophic diabetes. A therapeutic challenge]L Martins Ribeiro
Unidade de Endocrinologia Pediátrica, Servico de Pediatria, Centro Hospitalar do Porto, Porto, Portugal
An Pediatr (Barc) 78:54-8. 2013..The established diagnosis was then confirmed by identifying a mutation in the BSCL2 gene...
- Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophyXin Cui
School of Biotechnology and Biomolecular Sciences, Univ of New South Wales, Sydney, Australia
Am J Physiol Endocrinol Metab 302:E705-13. 2012Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder characterized by an almost complete loss of adipose tissue, insulin resistance, and fatty liver...
- Deletion mutation in BSCL2 gene underlies congenital generalized lipodystrophy in a Pakistani familyObaid Ur Rahman
Medical Genetics and Molecular Biology Unit, Biochemistry Department, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan
Diagn Pathol 8:78. 2013..There are four subclinical phenotypes of CGL (CGL1-4) and mutations in four genes AGPAT2, BSCL2, CAV1 and PTRF have been assigned to each type.
- Motor neuron degeneration in a mouse model of seipinopathyJ Guo
Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research A STAR, Singapore, Singapore
Cell Death Dis 4:e535. 2013Heterozygosity for missense mutations (N88S/S90L) in BSCL2 (Berardinelli-Seip congenital lipodystrophy type 2)/Seipin is associated with a broad spectrum of motoneuron diseases...
- A Patient with Congenital Generalized Lipodystrophy Due To a Novel Mutation in BSCL2: Indications for Secondary Mitochondrial DysfunctionEllen H Jeninga
Department of Metabolic Diseases, UMC Utrecht, Room KE 03 139 2, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
JIMD Rep 4:47-54. 2012..CGL) results from mutations in AGPAT2, encoding 1-acyl-glycerol-3-phosphate-acyltransferase 2 (CGL1; MIM 608594), BSCL2, encoding seipin (CGL2; MIM 269700), CAV1, encoding caveolin1 (CGL3; MIM 612526) or PTRF, encoding polymerase I ..
- Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and (1)H-MR spectroscopyXin Gui Peng
Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China
Am J Physiol Endocrinol Metab 304:E160-7. 2013..regulation of WAT and BAT, we investigated the fat fraction (FF) in two types of adipose tissues in ob/ob, human BSCL2/seipin gene knockout (SKO), Fsp27 gene knockout (Fsp27(-/-)), and wild-type (WT) mice in vivo using chemical shift ..
- Seipin regulates excitatory synaptic transmission in cortical neuronsShunhui Wei
Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A STAR, Singapore
J Neurochem 124:478-89. 2013..mutations in Seipin are associated with the Berardinelli-Seip congenital generalized lipodystrophy type 2 (CGL2, BSCL2), a condition that is characterized by severe lipoatrophy, insulin resistance, and intellectual impairment...
- A role for phosphatidic acid in the formation of "supersized" lipid dropletsWeihua Fei
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
PLoS Genet 7:e1002201. 2011..In summary, our results provide important insights into how the size of LDs is determined and identify novel gene products that regulate phospholipid metabolism...
- Molecular genetics and mechanisms of disease in distal hereditary motor neuropathies: insights directing future genetic studiesA P Drew
University of Sydney, Sydney, NSW, Australia
Curr Mol Med 11:650-65. 2011..The mutated genes identified to-date in dHMN include HSPB1, HSPB8, HSPB3, DCTN1, GARS, PLEKHG5, BSCL2, SETX, IGHMBP2, ATP7A and TRPV4...
- Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lgG B Downes
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
Genomics 53:220-30. 1998..Sequence analysis of the 5' flanking region of Gng3 revealed the presence of a novel gene, the gamma3 linked gene (Gng3lg)...
- The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicalsGiel Hendriks
Department of Toxicogenetics, Leiden University Medical Center, 2300RC Leiden, The Netherlands
Toxicol Sci 125:285-98. 2012..The Bscl2-GFP reporter is selectively activated after exposure to genotoxic agents and its induction is associated with ..
- A role for seipin in lipid droplet dynamics and inheritance in yeastHeimo Wolinski
Institute of Molecular Biosciences, University of Graz, Humboldtstr 50 II, 8010 Graz, Austria
J Cell Sci 124:3894-904. 2011..Deletion of FLD1, the functional orthologue of the human BSCL2 gene encoding seipin, leads to impaired dynamics of yeast lipid droplets and defective lipolysis, which might be ..
- The distal hereditary motor neuropathiesAlexander M Rossor
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 83:6-14. 2012..The causative genes have implicated proteins with diverse functions such as protein misfolding (HSPB1, HSPB8, BSCL2), RNA metabolism (IGHMBP2, SETX, GARS), axonal transport (HSPB1, DYNC1H1, DCTN1) and cation-channel dysfunction (..
- Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formationYuan Tian
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
PLoS Genet 7:e1001364. 2011..form of human lipodystrophy, Berardinelli-Seip Congenital Lipodystrophy 2, which is caused by mutations in the BSCL2/Seipin gene...
- Talon cusps, macrodontia, and aberrant tooth morphology in Berardinelli-Seip syndromeMishthu Solanki
Department of Pediatric and Preventive Dentistry, P M N M Dental College and Hospital, Karnataka, India
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e41-7. 2008..It is well documented in medicine and skin. It is a rare disorder caused by mutations of AGPAT2 gene or BSCL2 gene...
- Novel BSCL2 gene mutation E189X in Chinese congenital generalized lipodystrophy child with early onset diabetes mellitusJing Jin
Department of Endocrinology and Metabolism, Children s Hospital of Fudan University, Shanghai 200032, China
Eur J Endocrinol 157:783-7. 2007..Congenital generalized lipodystrophy (CGL) is a rare and heterogeneous disease of autosomal recessive inheritance. Until now, no genetic findings had been reported in Chinese patients with CGL...
- Founder effect of the 669insA mutation in BSCL2 gene causing Berardinelli-Seip congenital lipodystrophy in a cluster from BrazilK B Gomes
Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Ann Hum Genet 71:729-34. 2007..The 669insA mutation in exon 4 of the BSCL2 gene was identified as the major genetic alteration leading to BSCL in a group of 22 patients from the ..
- Phenotype of Charcot-Marie-Tooth disease Type 2H M E Bienfait
Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
Neurology 68:1658-67. 2007..To investigate the clinical and electrophysiologic phenotype of Charcot-Marie-Tooth disease (CMT) Type 2 in a large number of affected families...
- The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcomeG C DeLuca
University Dept of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6LE, UK
J Neurol 254:1221-6. 2007..the pathogenesis of HSP (Paraplegin, NIPA1, KIF5A, HSPD1, Atlastin, Spartin, Spastin, PLP1, L1CAM, Maspardin and BSCL2) play a role in susceptibility to, or modifying the course of, MS, although small effects of these genes cannot be ..
- Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolismRobert A Hegele
Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Lipid Res 48:1433-44. 2007....
- [Primary lipodystrophies]J Capeau
INSERM, U680, 75012 Paris, France
Ann Endocrinol (Paris) 68:10-20. 2007..or Berardinelli-Seip syndrome) result, in most cases, from recessive mutations in one of two genes: either BSCL2 coding seipin or BSCL1 coding AGPAT2, an acyl-transferase involved in triglyceride synthesis...
- [Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue]Jacqueline Capeau
INSERM, U680, Universite Pierre et Marie Curie, site Saint Antoine, Faculte de Medecine, 27, rue Chaligny, 75571 Paris Cedex 12, France
C R Biol 329:639-52; discussion 653-5. 2006..Acquired forms are common and regroup the highly prevalent Metabolic Syndrome, hypercorticism together with lipodystrophy related to antiretroviral treatment of HIV-infected patients...
- Berardinelli-Seip congenital lipodystrophyKausik Mandal
Department of Pediatrics and Dermato logy, Kalawati Saran Childrens Hospital, New Delhi 110 001, India
Indian Pediatr 43:440-5. 2006..On the basis of mutational and haplotype analysis, BSCL families have been classified into three types BSCL 1, BSCL2 and BSCLX...
- Diseases of adipose tissue: genetic and acquired lipodystrophiesJ Capeau
INSERM U680, Saint Antoine Faculty of Medicine, Université Pierre et Marie Curie UPMC, Paris, France
Biochem Soc Trans 33:1073-7. 2005..Such syndromes help to understand the mechanisms involved in insulin resistance resulting from altered fat repartition and could benefit from insulin-sensitizing effects of lifestyle modifications or of specific medications...
- Congenital generalized lipodystrophy: profile of the disease and gender differences in two siblingsM Raygada
Laboratory of Clinical Genomics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4429, USA
Clin Genet 67:98-101. 2005..been identified to harbor the mutations causing this disorder: BSCL1 mapped to human chromosome 9q34 (1, 2) and BSCL2 mapped to human chromosome 11q13 (1, 3)...
- Mice with deficiency of G protein gamma3 are lean and have seizuresWilliam F Schwindinger
Geisinger Clinic, Weis Center for Research, 100 North Academy Ave, Danville, PA 17822, USA
Mol Cell Biol 24:7758-68. 2004..Gng3-/- mice show no detectable expression of the Gng3 gene, but expression of the divergently transcribed Bscl2 gene is not affected...
- Genetic basis of congenital generalized lipodystrophyA K Agarwal
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Int J Obes Relat Metab Disord 28:336-9. 2004..in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and Berardinelli-Seip congenital lipodystrophy 2 (BSCL2 or Seipin) genes in affected subjects from pedigrees linked to chromosomes 9q34 and 11q13, respectively...
- Monogenic forms of insulin resistance: apertures that expose the common metabolic syndromeRobert A Hegele
Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406 100 Perth Drive, London, Ontario, N6A5K8, Canada
Trends Endocrinol Metab 14:371-7. 2003..which results from mutations in either AGPAT2 (encoding 1-acylglycerol-3-phosphate O-acyltransferase) or BSCL2 (encoding seipin), can display features seen in the common metabolic syndrome...
- Prevalence of mutations in AGPAT2 among human lipodystrophiesJocelyne Magré
INSERM U 402, Saint Antoine Faculty of Medicine, University of Pierre and Marie Curie, 27 rue Chaligny, 75571 Paris Cedex, France
Diabetes 52:1573-8. 2003..Because we found mutations in 92 of the 94 BSCL patients studied, the seipin gene and AGPAT2 are the two major genes involved in the etiology of BSCL...
- Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitusP J Kaisaki
The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, United Kingdom
Cytogenet Genome Res 98:71-4. 2002..Radiation hybrid analysis localized the seipin gene (Bscl2) in rat to a major quantitative trait locus in rat chromosome 1 linked to glucose intolerance in the Goto-Kakizaki ..
- Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophyL Van Maldergem
Centre de Genetique Humaine, Institut de Pathologie et de Génétique, Loverval, Belgium
J Med Genet 39:722-33. 2002..More recently, mutations in a previously undescribed gene of unknown function (BSCL2) on chromosome 11, termed seipin, have been found to be responsible for this disorder in a number of European and ..
- Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophyC A Kim
Department of Pediatrics, Instituto da Criança, University of Sao Paulo, 05403 900 Sao Paulo, Brazil
J Clin Endocrinol Metab 93:1129-34. 2008..In most reported cases, BSCL is due to alterations in either seipin, of unknown function, or 1-acylglycerol-3-phosphate acyltransferase-beta (AGPAT2), which catalyzes the formation of phosphatidic acid...
- [Silver syndrome--case report]Andrzej Kochanski
Zespół Badawczo Leczniczy Chorób Nerwowo Mieśniowych, Instytut Medycyny Dooewiadczalnej i Klinicznej Polskiej Akademii Nauk im M Mossakowskiego w Warszawie
Neurol Neurochir Pol 41:562-6. 2007..The underlying genetic defects are two mutations in the BSCL2 gene which have been described in several families...
Research Grants11
- A Simple Cellular Model for LipodystrophyJoel M Goodman; Fiscal Year: 2013..Overall, our proposed work will increase our understanding of droplet assembly, the basis of obesity and lipodystrophy, at its most basic level. ..
- Novel Therapies for Metabolic Complications in Patients with LipodystrophiesAbhimanyu Garg; Fiscal Year: 2010..Additionally, the findings may be applicable to treating metabolic complications in patients with obesity and type 2 diabetes. ..
- MECHANISMS OF LIPODYSTROPHY IN HIV INFECTED PATIENTSAbhimanyu Garg; Fiscal Year: 2002..Additionally, the study may prove effectiveness and reduced toxicity of alternative antiretroviral regimens without a PI. ..
- Therapeutic Approaches to HAART-Induced LipodystrophyAbhimanyu Garg; Fiscal Year: 2006..Additionally, the study may help prevent these problems in HIV-infected patients being initiated on PI-containing HAART. ..
- Lipoprotein Metabolism 2008 Gordon Research ConferenceRobert Hegele; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- Phase II study of cholic acid for hepatic steatosis in *Abhimanyu Garg; Fiscal Year: 2008..The effectiveness of cholic acid in reducing hepatic steatosis in humans remains unknown. [unreadable] [unreadable]..
- Hereditary Spastic Paraplegia due to SPG3A/atlastin mutationJohn Fink; Fiscal Year: 2009....
- International Symposium for Hereditary Spastic ParaplegiaJohn Fink; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,John Fink; Fiscal Year: 2001..abstract_text> ..


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Hotfrog Singapore provides information regarding Genps in Singapore. Genps is located at 3 Toh Tuck Link #02-07A German Distribution Centre, Singapore 596228 and provides Engineering services. Contact them on 6465 0105.
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Pregnant Again? Blac Chyna Sports Suspicious Bump While Stepping Out With Another Man
- 07:10 AM, Feb 21
McKayla Maroney to Appear on Entertainment News Show Extra
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awesome music.sound amazing
Wow, you have a great sound! I don't know if you ever heard of infected mushroom they are similar to your sound I am a big fan of them, now I am a fan of you.
Yeah, they actually played in my city days ago. Thanks for your very kind words and keep creating great stuff as well.
best to you
very creative and unique .,.great job
Loved listening to your music today!
Great arrangements - love the drums/percussion!
Nice textures Elmer. Best to you, Eric
Thanks for that Eric! Best to you as well and your Music.
Beautiful meeting of musical moods Elmer!!
I´m glad you enjoyed it John, and thanks for your good vibes.
showin support from london
Good stuff. My favorite is The son of the sun... :-)


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Open mouth while sleeping
While im sleeping i open my mouth and sleep,but i dnt snore..jst i open my mouth while sleeping..i wil not be conscious... when i open my mouth nd sleep..so i want to close.my mouth and sleep
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Doctor Answers (1) on Open mouth while sleeping
Dr. Anil Kumar Jain
Bangalore | General Physician
INR 150 for 24 hrsCHAT NOW
Hello there . I can undertand your concern . Its perfectly normal to sleep with an open mouth . Infact , many people sleep with open mouth . Its not harmful to sleep with an open mouth , apart from the odd chances of bugs getting inside .there is no medicine as such to make a person close the mouth while sleeping . You just have to train yourself . Best regards, Dr. Anil Kumar Jain.
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Photo of the Week: Promoting Entrepreneurship in Chile
August 23, 2013
The Emerge program is helping a new Santiago cybercafé and other promising small and growing businesses in Chile achieve their potential.
Rosa Paulina Díaz, right, chats with customers in her cybercafé in Colina, Chile. Paulina's business began as a small, home-based convenience store with a single computer that she rented to neighbors. When Paulina noticed a growing demand for Internet access and computer skills in her community, she sought support from Anglo American's Emerge program, operated by TechnoServe and local universities, to take her business to the next level.
Anglo American's Emerge program is honored to receive the 2013 Sello Más por Chile award from the Ministry of Social Development of Chile. Learn more
The program helped Paulina develop a business plan that included expanding into a commercial space next door and investing in three more computers. In addition to offering computer access and snacks and beverages, the cybercafé now provides services in graphic design, PowerPoint presentations and résumé creation. By November 2012, Paulina's sales had increased by 142 percent compared to the previous year.
Anglo American's Emerge program has been supporting small and growing businesses with high growth potential since 2006, creating job opportunities and providing key products and services in communities where Anglo American operates. TechnoServe began implementing the program in 2011, providing one-on-one consulting to help entrepreneurs like Paulina develop business plans, build critical skills and access markets and sources of financing. Of 450 applicants, 160 entrepreneurs were selected to take part in the Emerge program this year.
Read more about the Emerge program in our Annual Report – and see how TechnoServe's work benefited 2.9 million people in 2012.
Related Blog Posts
British Foreign Secretary Meets Ghanaian Entrepreneurs
Rising stars on Ghana's entrepreneurship stage chat about business growth with Boris Johnson during a high profile visit.
Small Businesses Fighting Hunger
Pauline Kamau's milling business has undergone a transformation, and is now part of a greater movement to curb malnutrition in African communities.
A New Crop for a New Beginning
After being driven from his land by drug violence, a cocoa farmer partners with TechnoServe to create a fresh, sustainable future.


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24/7/365 Water Removal in Silsbee
The best choice for restoring your daily life !
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Water damage restoration consists of going into a residence or building following a water leak, seeping roof, sink or tub overflow, flood, or storm damage and not just cleaning up the mess, but actually drying and repairing the substructures that elevated amounts of humidity will impair sheet rock, floor molding, wood framework, and metal structure. Mold is a concern along with lots of additional issues linked with wetness ; falling apart drywall and stucco, and deteriorating beams. If the wetness is allowed to rest long enough , it is going to sooner or later bring your home to ruin. CatStrong Restoration staff members possess proficient water damage restoration training where our crew will have the ability to correctly assess the condition and formulate the best plan for your property's restoration.
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Water Damage Cleanup in Silsbee, TX
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Time plays a critical function in limiting the damage caused by water. When water damage occurs' it can be kept to a minimum when responded to within 12 to 24 hours. CatStrong Water Damage Restoration has a full inventory of specialized equipment on the way. 24 Hours a Day, 365 Days a Year Complete Water removal. CatStrong water extraction in Silsbee TEXAS, removes Water as soon as possible from your home or business (Wet Carpet Cleaning, Wet Walls, Wet Contents, Wet furniture, Wet Draperies)
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MDG T-Shirt Shop - T-Shirts / Gifts & More > Pirate Master > Pirate Master Baseball Hat
Pirate Master Black Cap - Green Skull with crossing sabers. Text is Pirate Master, brought to you by MDG. Pirate Black Cap. Aarr Matey, Awesome Pirate Gifts.
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car finance, car leasing, contract hire
CarLease247 is the UK's ultimate site for car leases. We compare car lease providers so you don't have to. At CarLease247 you can configure your perfect car and then compare up to three side-by-side on the same screen. Choose the colour you want and the options you want 24 hours a day 7 days a week. If you are getting frustrated with car fleet or company car issues, get in touch.
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Are you holding out for the blood test Kate or are you POAS???
Are you holding out for the blood test Kate or are you POAS???
No I haven't done any tests yet. I'm pretty nervous about it - getting cramps still.
Are you going to do one tomorrow? I am busting to see how you go. So hopeful for you. Hopefully the cramps are a good sign of emby burrowing in and growing. Fingers crossed.
If I remember correctly you never POAS do you Kate? (That would surely drive TK crazy, haha!)
Cramps could very well be a very good sign.
Tomorrow is the big day isn't it? I can't believe you have held out this long! You are one strong woman! Fx!
Betty you know me too well.... :-)
Betty you are right - never done home tests! Nurses said not to do them as I had the HCG injections.
Im really hoping the symptoms are pregnancy related - my back was so sore last night - I'm home today as only managing few hours sleep a night & I'm exhausted. I'm trying to remain positive but feeling a bit flat.
Kate I don't POAS either, though always feel like cracking the day before!
Symptoms sound positive, fingers crossed for tomorrow, we will all be thinking of you
These last few days are so tough. You are almost there Kate xx
Thinking of you today Kate. xx
Pregnant for the first-time?
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Would you like to add new benefits to non company car drivers? Choose Employee Car Schemes.Cars are a powerful workplace benefit which do not need to be restricted only to company car drivers. With one of our Employee Car Schemes you can offer attractive car finance deals to all your employees at little or no cost to your business. We set up and run the scheme for you, and it can be branded as part of your own benefits scheme if you wish.
You could offer employees an affinity scheme supported by selected manufacturers which covers both company cars and personal ownership. We make it easy for your drivers with online quoting and ordering and guidance from our experienced support team.
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Legal Jobs In United States
Browse For Legal Jobs In United States. Find The Job Of Your Dreams On SHRM's HR Jobs Today!
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- American Management Association
- New York, New York 10019 United States
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American Management Association (www.amanet.org) is a world leader in talen... More Details
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- American Bar Association Rule of Law Initiative
- Washington, District of Columbia 20036 United States
- 01/26/2017
- Legal
ABA ROLI is a non-profit organization that implements legal reform programs in roughly 50 countries around the world. ABA ROLI has nearly 500 professional staff working abroad and in its Washington, D.C. office. ABA ROLI's host country partners include judges, lawyers, bar associations, law scho... More Details
- United Technologies
- Farmington, Connecticut 06032 United States
- 02/09/2017
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Supports job levelling processes/tools globally Supports compensation benchmarking, annual survey participation and coordination Reviews survey results and provides analysis on company competitiveness vs. external market Maintains salary structures globally Supports the development and maintenance o... More Details
- MTA Bus Company
- New York, New York 10004 United States
- 01/27/2017
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SET YOUR CAREER IN MOTION! Join the MTA Bus Company As Assistant Chief Officer, Investigations MTA Bus Company along with New York City Transit Department of Buses is the largest bus agency in North America. MTA Bus including NYCT Department of Buses has over 18,000 employees and a fleet of 5,700... More Details
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- San Antonio, Texas 78205 United States
- 02/02/2017
- Administrative
The Assistant Human Resources Director assists the Director in planning, directing, managing, and overseeing several divisions or programs of the Human Resources Department. The department has a total budget of $168 million (which includes the citywide benefits fund) and 109 assigned staff members. ... More Details
- Franklin & Marshall College
- Lancaster, Pennsylvania 17604 United States
- 02/10/2017
The Assistant Director aids the Associate Vice President, Human Resources managing all aspects of department operations and support of the Human Resources Information System (HRIS), Ellucian's ERP, Banner. The Assistant Director manages the recruitment and hiring functions for non-faculty positions ... More Details


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Private In-Home and Online Trigonometry Tutoring in Aurora, IL
Receive personally tailored Trigonometry lessons from exceptional tutors in a one-on-one setting. We help you connect with in-home and online tutoring that offers flexible scheduling and your choice of locations.
Recent Tutoring Session Reviews
"We went over a handout that the student's teacher gave her that seemed to be easing its way into trigonometric identities and proofs."
"The student and I reviewed the six trigonometric functions. Additionally, the student just began the subject of radians. We went through her textbook and used the examples given in order to make sense of the concept. By the end of the session, she was able to explain the difference between radians and degrees, why there is a difference, and how to convert between the two."
"We went over how to graph inverse trigonometric functions. We reviewed some concepts from last week and put all they learned together for their exam."
"We reviewed graphing sinusoidal functions. The student has a strong grasp on the subject, and I expect him to do well on future testing. His only problem is concluding an answer too early. I explained methods of self-checking, that if he takes the time to do, will ensure correct answers."
"We went over the questions she got wrong on her previous test, in particular regarding shifts of sin/cos functions and using arc functions."
"The student and I reviewed assignment 5.4 and most of 5.5. The material was better prepared for and less complex than our last lesson and the student was able to complete the work with little difficulty. We did get hung up a little bit on some of the word problems from section 5.5, but we will address those in our next session. The sections covered vectors and the dot product."
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Nearby Tutors:Evanston Trigonometry Tutors, Skokie Trigonometry Tutors, Oak Park Trigonometry Tutors, Downers Grove Trigonometry Tutors, Highland Park Trigonometry Tutors, Des Plaines Trigonometry Tutors, Glencoe Trigonometry Tutors, Naperville Trigonometry Tutors, Oak Lawn Trigonometry Tutors, Elmhurst Trigonometry Tutors, Lombard Trigonometry Tutors, Schaumburg Trigonometry Tutors, Lake Forest Trigonometry Tutors, Buffalo Grove Trigonometry Tutors, Wheaton Trigonometry Tutors


text: I own all of the following, among others, except for the HCSB which I have read online. If you are not KJVo, what are your opinions of the following five translations and would you recommend it for study or other use? 1. HCSB 2. NASB 3. NRSV 4. NIV 5. NLT


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Davidson has a population of 7,139 and is located in Iredell county.
For North Carolina residents, the average tuition for all Davidson music schools for the 2009 - 2010 school year was $34,776.00. For non-residents, the average tuition for Davidson music schools was $34,776.00.
The average cost of books and supplies for music schools in Davidson is $1,000.00. Students have a choice of one music college in Davidson to attend. In the 2008 - 2009 school year, reportedly 7 students completed music programs in Davidson.
|Average Salary
|Number Employed in City
|Art, Drama, and Music Teachers, Postsecondary
|Music Directors and Composers