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Complete your living room with an area rug! Shop Rugs
Looking for style and storage for your TV room? This entertainment wall unit provides you with a TV stand in the center, two media towers on each side, and a bridge on top with a shelf. This complete unit can fit any TV up to 60-inches and 220 pounds. Use the three bottom shelves for media consoles and other side and top shelves to display decorative items or hold books. Meanwhile, hide away games and DVD in the drawers to maintain a clutter-free space. Not only is this piece functional, but it is stylish, as it is has clean lines, sleek silver-colored hardware, and a cappuccino finish. For an organized, useful, and beautiful living room, look no further than this entertainment wall unit.
The Entertainment Units Entertainment Wall Unit with 6 Drawers and 8 Shelves by Coaster at Del Sol Furniture in the Phoenix, Glendale, Tempe, Scottsdale, Avondale, Peoria, Goodyear, Litchfield, Arizona area. Product availability may vary. Contact us for the most current availability on this product.
Choose from a variety of wall units to fit your needs and complement your home decor! With many different styles, finishes, and sizes available you are sure to find an option that you love. With plentiful media storage options, and entertainment solutions, these entertainment wall units will keep your family and friends happily entertained for hours, without compromising the style of your living room or family room.
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This item has been tagged as: Wall Unit, Modular Pieces, TV Wall Unit, Living Room Wall Unit, Bedroom Wall Unit, Wall Storage Unit, Corner Wall Unit, Wall Shelving Unit, Media Wall Unit, Home Furnishings, Media Center, Entertainment Center, Entertainment Wall Units, TV Wall Unit, Television Wall Unit, Extended Entertainment Walls, Entertainment Unit, TV Furniture, Living Room Furniture, Entertainment Furniture, TV Armoire, Television Armoire, Media Storage, Bookcases, Wall Bookcase, Home Theater Furniture, Home Entertainment Furniture, Bookshelves, Home Theater Storage, Entertainment Armoires, Curios, Wall Curio, Curio Cabinets, Wall Curio Cabinets
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TCM Archive Materials VIEW ALL ARCHIVES (0)
Recent DVDs
I Accuse My... In this over-the-top forties' exploitation film, a teenager who gets mixed up... more info $5.95was $6.98 Buy Now
Glenn Ford:... Turner Classic Movies and Sony Pictures Home Entertainment proudly present GLENN... more info $39.55was $54.99 Buy Now
Perfect... Ginger Rogers and Dennis Morgan show they still have plenty of screen chemistry... more info $14.95was $17.99 Buy Now
Arch of... In 1938, Paris Has Become a Haven for Refugees Trying to Escape Growing Nazi... more info $17.15was $24.95 Buy Now
|Also Known As:
|Cause of Death:
|Birth Place:
|Cast ...
Cast (feature film)
Western outlaws join forces for a daring gold robbery in this remake of The Asphalt Jungle.
A married couple endures endless red tape when they try to adopt a child.
At Rio Galdez's remote Brazilian trading post live assorted outcast Americans and Europeans, including Jerry Russell, ex-engineer who became obsessed with the Jivaro headhunters' treasure, quit his job, and took up with the bottle and local girl Maroa. But he still gets letters from his nominal fiancée in California, and unexpectedly the shapely, glamorous Alice Parker arrives, expecting to marry a rich planter. Disillusioned, Alice is almost ready to fall into Rio's arms when news comes that Jerry is missing in Jivaro country...
Baseball great Grover Cleveland Alexander fights his way back from a blinding injury.
A female gangster learns she is losing her vision.
American adventurer Jim Bowie fights to make his way in the lumber business.
Two bumbling private eyes turn a boxer invisible to save him from being framed for murder.
A crusading district attorney takes on the mob''''s murder machine.
An ex-police/army dog (German Shepherd), named Rex inherits a fortune from an eccentric millionaire. But someone poisons him for his fortune, and he gets to go back to earth as a human detective to bring his killer to justice, and protect the girl who used to look after him.
A backwoods politician rises to the top only to become corrupted.
A publicity hungry press agent creates a romance between an icy college dean and a visiting lecturer.
To appease his family, a retired baseball player signs up for umpire school.
A divorcee finds love with a married man while they both sit on a jury.
When the American clipper ship "The Queen" is attacked by pirates off the Hebrides in 1830, Mate Kirk Hamilton is injured and must be put ashore at Queensland Colony, Australia, for treatment and recuperation. There, he meets and falls in love with Elaine Jeffries, daughter of the magistrate and all-but-fiancée to rancher Martin Shannon. She also finds herself attracted to Kirk, and a rivalry develops between the two men. Meantime the pirates, led by Captain Hackett, decide to raid the colony and, in the process kidnap Elaine and her friend, Nancy. Kirk and Shannon lead the pursuit, having not only the romantic triangle to resolve but the pirates to overcome and, along the way, being stranded on a volcanic island inhabited by dinosaurs...
A brutal bank robber fights internal divisions within his gang.
This first movie version of the Tennessee Williams play about a faded, aging Southern belle, her shy, crippled daughter and her "selfish dreamer" of a son more or less sticks to the original story, except for a compromise ending which strives to be more upbeat.
A treasury agent tries to convict a ruthless mobster of tax evasion.
A young man succumbs to gambling fever.
A crusading lawyer fights to save a juvenile delinquent charged with murder.
An artist discovers a real-life version of the perfect woman he's been drawing for years.
In winter of 1938, Paris is crowded with refugees from the Nazis, who live in the black shadows of night, trying to evade deportation. One such is Dr. Ravic, who practices medicine illegally and stalks his old Nazi enemy Haake with murder in mind. One rainy night, Ravic meets Joan Madou, a kept woman cast adrift by her lover's sudden death. Against Ravic's better judgement, they become involved in a doomed affair; matters come to a crisis on the day war is declared.
When he accidentally injures a young girl, a gangster risks his freedom to nurse her.
A married woman''s passion for a former love drives her mad.
An elderly millionaire makes a hobby of playing cupid.
Fanciful biography of songwriter Cole Porter, who rose from high society to find success on Tin Pan Alley.
True story of the Australian nurse who fought to gain acceptance for her polio-treatment methods.
A singer can''''t choose between a charismatic gangster and an honest newspaperman.
A psychiatrist tries to help the man she loves solve a murder buried in his subconscious.
A man's wild moneymaking schemes leave his wife to raise their family.
Two Russians fight to escape the seven Nazi soldiers trapped with them in a bombed building.
A reformed thief accidentally sells a phony first edition of Dickens, which triggers a murder.
Ignored by his alcoholic parents, Jimmy Wilson starts hanging around with some shady characters. After falling in love with a lounge singer, Jimmy tries to impress her by doing jobs for her shady boss. After one of these jobs goes bad, Jimmy ends up on the run. Eventually, he must confront the truth, his past, and his parents.
A small-town doctor tries to help a beautiful woman with a deranged husband.
In-law problems threaten a wartime marriage.
Rosalind Russell, Fred MacMurray, Herbert Marshall, Eduardo Ciannelli, Walter Kingsford, Jack Carr, Hugh Beaumont. Loosely based on the career of Amelia Earhart, this aviation drama features Rosalind Russell as a female pilot who breaks the Los Angeles to New York record and attracts the interest of the U.S. Navy who want to send her on a spy mission
A wheelchair-bound doctor tries to prove a convicted killer's innocence.
A small-town politician is the jury hold-out in a sensational murder case.
Pit violinist Claudin hopelessly loves rising operatic soprano Christine Dubois (as do baritone Anatole and police inspector Raoul) and secretly aids her career. But Claudin loses both his touch and his job, murders a rascally music publisher in a fit of madness, and has his face etched with acid. Soon, mysterious crimes plague the Paris Opera House, blamed on a legendary "phantom" whom none can find in the mazes and catacombs. But both of Christine's lovers have plans to ferret him out.
Two sisters - one smart, one pretty - move to New York to build careers.
Cast (special)
The story, set in 1864, relates the adventures of Sam Hill, a traveling blacksmith of legendary strength who roams throughout the West with only a knife and a hammer. In the pilot episode, Sam tries to protect a piece of land he owns from a colonel who is seeking to buy it--at any cost.
Please support TCMDB by adding to this information.Click here to contribute

subset: commoncrawl


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About our Puzzle Craft 2 Hack
This Puzzle Craft 2 hack is capable of generating an unlimited amount of Runes and Coins. Our Puzzle Craft 2 cheat used to be a standalone downloadable package, but we are incredibly proud of the fact that we have managed to make it an online generator. Along with our built in proxy support it makes it 100% safe and undetectable. Legitimate Puzzle Craft 2 cheats are hard to come by and as far as we are aware, ours is currently the only working and regularly updated Puzzle Craft 2 hack tool available on the web for free.
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Scarlett Johannson conquers TV
The beautiful Scarlett Johansson is ready for TV having landed a role in The Custom of the Country series
coming soon...
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Last On Vogue
Vittoria Mentasti - Dead Sea
Vittoria Mentasti's Dead Sea takes us to a place where the sky and the sea are one
Kristin Prim and The Provocateur's letters
A chat with Kristin Prim, the founder of The Provocateur, the site that publishes letters written expressely by leading women addressing the whole female world. Vogue.it presents you an exclusive preview of the letter written by Dresden Dolls' Amanda Palmer
Fashion shows are changing: Burberry and all that's new on the runways
Menswear and womenswear collections will walk together and will be on sale right after the show. These are the news from Burberry but the evolution is generalized: runway shows are changing


text: Posted March 2, 2008 Was out this afternoon for a enjoyable afternoon of fishing & as I was hole hoping I came across a spot that a perm house was & there layed 2 empty beer cases, along with a whole plastic bag of fish remains, ( yes it was on duck lake ) sure wish this would of had some I.D in this mess. ---but the bottom line is clean your s---t up so the next guy doesn't!!!!!!!!!!!!!!! Share this post Link to post Share on other sites


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Not a member yet? Join now
I'm currently based in Sabadell and would like to find a place for long term placement ( <1 Year>). Preferably Gracia or near to city. I don't mind sharing the apartment.
Kindly please let me know if you guys know any contacts. Appreciated for the attention.
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Please join us to royally shower the Queen Mother for her baby princess, who will soon be sharing in the fun! Enchant your guests with this flower baby shower invitation design. Fairy blossoms in girly shades of purple & pink surround a scroll, which holds your invitation wording. A princess castle, tiara, and sceptre add to the fairytale theme, and you can use any of the themed phrases seen on this example.
All of the colors and graphics are customizable as well, just put your requests in the notes field here: Princess Baby Shower Invitation (pick this version in the form if you like it).


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April 19, 2013
By Evan Lockridge
A trucking provider to the air cargo industry, Forward Air, reports both income and revenue during the first quarter of the year moved higher.
Net income increased to $10.9 million from $10.3 million in the prior-year quarter while revenue increased 3.3% to $141.6 million from $137.1 million for the same quarter in 2012.
"The first quarter proved to be a more challenging operating environment than we originally expected, said Bruce A. Campbell, Chairman, President, and CEO. "Airport-to-airport volumes, which were up slightly at the beginning of the period, did not show their typical end-of-quarter strength. Beyond a continued weakness in the overall macroeconomic environment, we were challenged by consistently harsh weather throughout the quarter as well as increased irrational pricing from our competition."
Rodney L. Bell, Senior Vice President and CFO, said he believes the company will see second quarter revenue increase between 12% to 18% over the same period last year. "We estimate that approximately 9% of that growth will result from the TQI acquisition"
In early March Forward air purchased Total Quality Inc. a provider of maximum security and temperature-controlled services to the pharmaceutical and life science industries for approximately $66 million.
More details on the company's first quarter performance is on the Forward Air web site.
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Scott Sutarik from Geotab, will answer your questions
The expert, Steve Carlson from Xantrex, will answer your questions
On the Spot: First Impressions of Volvo's SuperTruck
Ultimate Test Drive: New Cascadia Sleeper Lounge [Video]
Ultimate Test Drive: Freightliner's New Cascadia Pt. 2 [Video]
Ultimate Test Drive: Freightliner's New Cascadia Pt. 1 [Video]
Mud Flap Retention System Can be Installed by Hand
Kits Offer More Compatibility for VDO RoadLog ELD Users
Retract-A-Roll Pneumatic Roller Track System Improves Cargo Handling
Dashboard Mount Designed for ELDs, Smart Devices


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Bubbles N Suds Gift Baskets
Gifts, Corporate Gifts, Corporate Gift Baskets
We are now offering beautiful wedding favors and gifts at Bubbles N Suds! Make you big day that much more special and support your local Artisans by choosing hand crafted Wedding Favors through us! We offer a variety of elegant handmade favor boxes and bags filled with natural soaps and salts made by Vancouver Island Artisans. We can customize any of the favors by scent and color to match your wedding design and offer a variety of packaging options. We would love to help you make you Wedding Day the best it can be!
Print this page
Romantic Gifts and Gift Baskets filled with sensual products hand crafted by Vancouver Island Artisans.
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I will make A Stunning Static or Flash Banner For Your Marketing Needs(22)
About This Gig
Order Details
Unique Static and Flash Banners
High quality static and flash banners. Bonus banner advertising, video creation and advertising
Frequently Asked Questions
What type of banners you provide with this gig?I can provide static jpeg, png or animated flash banners. You can also check my other gig for HMTL5 banners.
How to upload the banner to my website?If the banners are static you don't need any special skills but if your banner is animated flash you have to ask your webmaster how to use flash files if you are not experienced enough.
What do you need from me?It would be great if you can provide some images, the idea of the banner you need, some text and most important - the required resolution
Can you make the banner clickable to a specific url?Yes, please provide the specific url address and call to action text
Can I use the banner on social platforms?You can use and upload static banners and images but unfortunately currently social networks do not support flash animation and banners.
Where can I use such flash banner?You can use it on your own website, sites and networks that support flash.


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2016 was a big year for beer in Georgia. Among other things, MillerCoors took a majority stake in Athens-based Terrapin and Brick Store Pub joined the Knighthood of the Brewers' Paddle… 299 more words
Tags » Chamblee
The Halal Guys set to open in Chamblee this month, celebrating with free food
The long wait is (almost) over — The Halal Guys is ready to make its Georgia debut, and give out some free food in the process. 251 more words
GA - Relatives of Filipino missing in the US for 2 months seek help in finding her | Inquirer News
GA - Search underway for missing Chamblee mother | WAGA
Golden Hour.
Typically, these blog posts come fairly easy to me. I'll brainstorm ideas before I go to sleep, and by the time I wake up I have a clear vision of what I want to shoot. 506 more words


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@MISC{Polytechnic94typelogical, author = {Glyn Morrill Polytechnic and Glyn V. Morrill and Fernando Pereira}, title = {Type Logical Grammar: Categorial Logic of Signs}, year = {1994}}
tracting away from contingent aspects of the channel's physical realization and from the use of the information by the recipient. For instance, the finiteness of language processors demands that the meanings of sufficiently complex signs be a function of the meanings of their parts: thus compositionality. Without additional constraints, compositionality could be trivially satisfied (Zadrozny 1994). But the fact that language users derive their implicit contract for sign meaning from finite evidence imposes strong uniformity requirements on signs. While this argument has not, to my knowledge, been made rigorous through an axiomatic treatment, type-logical grammar offers a promising notion of uniformity: to say, for instance, that a sign c meaning z has type B/A is to say that c + a (where + is a suitable sign combination operator) has type B and means z(x), given that a has type A and means x. But uniformity must also go backwards, if the use and meaning of a sign is to be induced from
type logical grammar
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sign meaning
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implicit contract
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type-logical grammar
Developed at and hosted by The College of Information Sciences and Technology
© 2007-2016 The Pennsylvania State University


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The end justifies the means, said philosopher Machiavelli in his composition The Prince, suggesting that morals have no value in the quest for victory. While this may have worked for 16th-century authoritarian rulers who were aided by a certain level of secrecy, these tactics have a way of coming back to haunt people who have TV cameras filming their every move.
Welcome to the era of Machiavelli 2.0, when entering a TV competition program gives contestants the excuse to be as despicable as they like, because the public will witness the horrors that unfold and understand that it was all just part of "the game." Covert tactics are expected on shows like Survivor and Big Brother, where backstabbing and deception are necessary steps in manipulating the competition, and some of the sneakiest players have been the best (Russell Franz from Survivor could teach officials at the Pentagon how to deploy psychological warfare against the enemy). Then there have been contestants who seemed to spend less time playing the game and more time turning on each other, perhaps in desperate attempts to thin out the competition, or just for the thrill of the kill.
Here are the best of the worst, the most dangerous of villains, the nastiest players whose tactics would make even Machiavelli himself blush.
How will Donald Trump's first 100 days impact YOU? Subscribe, choose the community that you most identify with or want to learn more about and we'll send you the news that matters most once a week throughout Trump's first 100 days in office. Learn more


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Pakistan Army announced latest recruitment through 137 PMA Long Course with training duration of 2 years. Online registration has been began from 06th Oct to 11th Nov 2015. Willing persons must visit Pakistan Army website: joinpakarmy.gov.pk OR contact to the nearby Army selection centers in following cities of Pakistan: Rawalpindi, Lahore, Karachi, Peshawar, Quetta, Gilgit, Hyderabad, Multan, D.I Khan, Muzaffarabad, Faisalabad, Khuzdar and Pano Aqil.
Candidates who hold Intermediate or equal, Graduates (02 years graduation) & Serving PN/PAF personnel, Graduates (04 years) graduation program BS, BA (Hons.) BBA, BPA, can apply to Join Pak Army.
This advertisement also available in daily Dawn newspaper.


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Doyle included in conservation group's 'dishonor roll.'
The Wisconsin League of Conservation Voters said Tuesday that while there were some important wins, it decried many missed opportunities to advance environmental issues during the 2009-'10 legislative session.
Perhaps the biggest loss: Failure to pass an independent secretary at the Department of Natural Resources, the group said. Gov. Jim Doyle vetoed the legislation after years of supporting it; and for that, it earned the Democrat inclusion on the organizations "Conservation Dishonest Roll."
Business groups opposed the legislation and Doyle said that a governor's stronger oversight was preferable to having the seven-member board name the secretary of the agency. Conservationists said the DNR has become an increasingly political agency under the Doyle administration.
In addition to the DNR secretary bill, lawmakers failed to advance climate legislation and bills to protect ground and drinking water.
Here's the group's report.
- Live web cam of great blue heron nesting at Horicon
- Air quality alert issued by DNR
- Skymmr ends record debris removal season on Milwaukee rivers
- New video on fungus on Rock River
- George Archibald, crane conservationist, worries about state's whoopers
- Peregrine falcons produced record number of young
- First group of whooping cranes take off for fall migration
- Poll shows opposition to mine
- Sturgeon stocking in Lake Michigan Saturday at Milwaukee lakefront
- Mining hearing is live on public radio
- Wisconsin Department of Natural Resources
- Wisconsin State Parks and Forests
- Milwaukee County Parks
- Milwaukee's air quality
- Milwaukee Metropolitan Sewerage District
- Waukesha County Park System
- Ozaukee County Planning and Parks Department
- Washington County Planning and Parks Department
- The Nature Conservancy in Wisconsin
- Cedar Lakes Conservation Foundation
- Ozaukee Washington Land Trust
- Tall Pines Conservancy


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Scoop ice cream into sundae glasses. Top with warm Butterscotch Sauce, chopped toffee, whipped cream, and a cherry.
In a small heavy bottomed saucepan, add the brown sugar, corn syrup, and butter and cook over medium low heat, stirring, until sugar dissolves. Add bourbon and vanilla extract, stirring well.
Recipe courtesy of The Neelys
The best comfort food is comforting both to cook and to eat, like Ree's pork chops.


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1953 S Comanche Drive, Chandler, AZ 85286
5 beds, 3.5 baths, 4,257 sqft
Status: Active
Property Description
4257 Square Ft of Impeccable Luxury in Comanche Heights Basement Home with 5 Bedrooms and 3.5 Baths! The discerning Buyer will appreciate the details, from Designer Two-Tone Paint, 12ft Ceilings, Archways, Travertine Flooring, Crown Molding, updated Lighting/Fixtures to the expansive/functional Master Split Floorplan. The Formal Living/Dining space overlook the covered Patio and Glass Mosiac Tile Pool with Fountain Waterfall features. Kitchen/Family Room is open combination and a cooks dream with a Rock Fireplace, Island,Rich Cherry Cabinets,Stainless KitchenAid Appliances that all convey, Thermador Gas Stove-top and New Kitchen Aid Double Oven's. Basement office and Home Theatre TV and Cabinetry Built-ins convey. 3 Car Garage w/Built-in Storage, side yard RV Gate and storage or Dog Run.
Listing Information for 1953 S Comanche Drive Chandler, AZ 85286
Tw Lewis
SRP,SW Gas
School Information for 1953 S Comanche Drive Chandler, AZ 85286
Room Information for 1953 S Comanche Drive Chandler, AZ 85286
Family Room
Eat-in Kitchen, Formal
Kitchen Island, Granite Counter-tops
Double Sinks,Separate Shwr & Tub,Private Toilet Room,Full Bth Master Bdrm
Dual Sinks, Separate Tub & Shower
Interior Features for 1953 S Comanche Drive Chandler, AZ 85286
Gas Range/Cooktop, Wall Oven, Refrigerator, Multiple Ovens, Disposal, Dishwasher, Dryer, Washer
Carpet, Stone
Gas Heat
Finished, Full
Double Pane
1, Fireplace Family Rm
Central Vacuum, Water Softener (Owned), Drinking Water Filtering System
Exterior / Lot Features for 1953 S Comanche Drive Chandler, AZ 85286
3 Garage Spaces, 3 Parking Spaces, Electric Door Opener, RV Gate
Stucco, Painted
All Tile
Comanche Heights
Covered Patio(s), Cul-De-Sac Lot
Community Features for 1953 S Comanche Drive Chandler, AZ 85286
Park Play Area
Driving Directions to 1953 S Comanche Drive Chandler, AZ 85286
West on Germmann, North on Vineyard, East on Weatherby, North on Central Place, East on Weatherby, South on Comanche to Property on the east side of the street.
Financial Considerations for 1953 S Comanche Drive Chandler, AZ 85286
Listing Price History for MLS#: 5458449
Chandler AZ Real Estate and Chandler AZ Homes for Sale
Chandler is located in the state of Arizona. The zip code of 85286 has a population of 237,456. The median age of people living in Chandler, AZ 85286, is 33.9 years.
Click on the tabs below to see more details for the 85286 zip code in Chandler, Arizona.
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080 - Chandler Unified District school district


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Million Hearts Launches Annual Blood Pressure Control Challenge »
"The U.S. Department of Health and Human Services today launched an annual challenge designed to identify and honor clinicians and health care teams that have helped their patients control high blood pressure and prevent heart attacks and strokes."...
Read the Million Hearts Launches Annual Blood Pressure Control Challenge article »
The propranolol hydrochloride component may cause bradycardia, cardiac failure, hypotension, or bronchospasm. Propranolol is not significantly dialyzable.
The hydrochlorothiazide component can be expected to cause diuresis. Lethargy of varying degree may appear and may progress to coma within a few hours, with minimal depression of respiration and cardiovascular function, and in the absence of significant serum electrolyte changes or dehydration. The mechanism of central nervous system depression with thiazide overdosage is unknown. Gastrointestinal irritation and hypermotility can occur, temporary elevation of BUN has been reported, and serum electrolyte changes could occur, especially in patients with impairment of renal function.
The oral LD50 dosages in rats and mice for propranolol, hydrochlorothiazide, and combined propranolol/hydrochlorothiazide (40/25, 80/25) are 364 to 533 mg/kg, greater than 2,750 to 5,000 mg/kg, and 538 to 845 mg/kg, respectively.
The following measures should be employed:
General—If ingestion is, or may have been, recent, evacuate gastric contents, taking care to prevent pulmonary aspiration.
Bradycardia—Administer atropine (0.25 to 1.0 mg). If there is no response to vagal blockade, administer isoproterenol cautiously.
Cardiac Failure—Digitalization and diuretics.
Hypotension—Vasopressors, e.g., levarterenol or epinephrine.
Bronchospasm—Administer isoproterenol and aminophylline.
Stupor or Coma—Administer supportive therapy as clinically warranted.
Gastrointestinal Effects—Though usually of short duration, these may require symptomatic treatment.
Abnormalities in BUN and/or Serum Electrolytes—Monitor serum electrolyte levels and renal function; institute supportive measures as required individually to maintain hydration, electrolyte balance, respiration, and cardiovascular-renal function.
Propranolol hydrochloride (Inderal®)
Propranolol is contraindicated in 1) cardiogenic shock; 2) sinus bradycardia and greater than first-degree block; 3) bronchial asthma; 4) congestive heart failure (see "WARNINGS") unless the failure is secondary to a tachyarrhythmia treatable with propranolol.
Hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to this or other sulfonamide-derived drugs.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 11/18/2016
Inderide FDA Prescribing Information
Additional Inderide Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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In mammals, the visual field is split along the midline, each hemisphere representing the contralateral hemifield. We determined that, in the ferret, an 8- to 10-deg-wide strip of visual field near the midline is represented in both hemispheres. Bright squares (1.5 deg) were flashed at different azimuths within the central 20 deg of the visual field. Stimuli were flashed either alone or sequentially, and the responses were analyzed with the voltage-sensitive dye (VSD) RH 795 and/or by recording local field potentials (LFPs). In both VSD and LFP experiments, each stimulus evoked a cortical response field that extended over visual areas 17 and 18 up to a surface of 1–1.5 mm2 and then shrank again. Amplitude of the responses decreased approaching the visual midline and the latency increased. These positional differences are likely to originate from the spatiotemporal structure of the peripheral response fields (PRFs) that form a mosaic in areas 17 and 18, interrupted near the visual midline. Unexpectedly, interhemispheric connections appear not to modify these PRFs' effects and may not contribute to the responses to discrete, flashed stimuli.
The cerebral cortex contains orderly, discrete representations of the sensory peripheries, that is, the stimulation of neighboring points, on the peripheries, activates neighboring neurons in the related cortical areas. Two mechanisms contribute to integrating responses across the cortical sensory maps. One is the divergence/convergence in the afferent projections such that neighboring points in the sensory periphery activate overlapping cortical territories. The second are the tangential connections within the cortical maps. The cortical representations of the sensory peripheries are dynamic constructs, continuously updated by incoming inputs. The number and spatial distribution of cortical neurons activated by a peripheral stimulus (here referred to as the cortical response field [CRF]; see Discussion) change with time after stimulus onset, expanding and contracting over a time scale of 100–200 ms (Grinvald et al. 1994; Petersen and Diamond 2000; Petersen et al. 2003). This aspect of CRF dynamics is believed to reflect the tangential spread of activity along horizontal corticocortical connections (Petersen et al. 2003).
The splitting of the sensory representations between the 2 hemispheres raises special problems. The representation of the retina, in particular, is divided between the 2 hemispheres along a line corresponding to the nasotemporal decussation of ganglion cell axons at the chiasm. This line is unsharp, and therefore, a narrow strip of the visual field midline is represented in both hemispheres. Interestingly, the cortical representations of this strip are also preferentially interconnected by callosal axons (Innocenti 1986; Manger et al. 2002).
Here and in the companion paper (Makarov et al. Forthcoming), we investigate the role of interhemispheric connections in integrating the 2 hemirepresentations of the visual field. The rationale for the present study was the following. Whereas within the hemifield representations, the dynamics of the CRF should reflect conduction along the short intra-areal axons, near the visual midline they should reflect conduction along the long callosal axons. The different lengths and hence conduction delays of the 2 axonal systems should cause significant differences in the dynamics of the responses to stimuli presented along the midline versus those presented in the periphery of the visual field. However, the notion that callosal connections may fail to perfectly integrate the 2 hemifield representations conflicts with the widely accepted belief that the intrahemispheric (including intra-areal) and callosal axons are functionally equivalent, albeit specialized for different portions of the visual field (reviewed in Innocenti 1986; Kennedy et al. 1991). Furthermore, the recent evidence pointing to precise timing as an essential requirement in cortical function (e.g., Engel et al. 1997; Ikegava et al. 2004; Izhikevich et al. 2004) would suggest that the temporal properties of the response to a visual stimulus should be similar across the visual field.
To analyze how the visual field is integrated along the interhemispherically split visual midline, we first investigated the width of the bihemispheric visual field representation. We next flashed short-lasting square stimuli alone or in a sequence at different positions within the visual field and investigated the dynamics of the CRFs as function of stimulus distance from the midline using 2 complementary techniques, fast optical imaging with voltage-sensitive dyes (VSDs) and local field potentials (LFPs). We then recorded the peripheral response fields (PRFs), that is, the portions of the visual field from which responses can be obtained at a given cortical site, near the midline of the visual field, and studied their spatiotemporal structure and dynamics.
Materials and Methods
Fourteen female, adult ferrets (Mustela putorius), bought from a Swedish authorized breeder, were used in this study, subdivided among different experiments as detailed below. The animals were anesthetized with intramuscular doses of ketamine hydrochloride (Ketalar 10 mg/kg) and medetomidin hydrochloride (Domitor 0.3 mg/kg), supplemented with atropine sulfate (0.15 mg/kg). After inserting a cannula into the femoral vein and a tracheal tube, the animals were placed in a stereotaxic frame and maintained on gas anesthesia (1–1.5% isoflurane in 1:1 nitrous oxide and oxygen). The animals were paralyzed with an initial intravenous injection of pancuronium bromide (Pavulon 0.15 mg/kg), supplemented with a continuous infusion of the same drug (6 μg/kg/h, 3 mg in 50 ml normal saline, with 10% glucose). The animal was artificially respirated, and expired CO2 was maintained at 3.3–4.0%, body temperature at 37–38 °C, and heart rate was constantly monitored. All experiments were conducted according to the Swedish and European Community guidelines for the care and use of animals in scientific experiments.
The visual cortex was exposed in the right hemisphere (or in both; below) and protected with mineral oil. Varnish-insulated tungsten microelectrodes (0.95–1.3 MΩ, exposed tip of ∼15 μm), were inserted to 300–500 μm below the pial surface. The position of the penetrations was marked on a photograph of the cortical surface taken at the beginning of the experiment. The signals amplified via WPI DAM-5A and Tektronix AM502 amplifiers were studied in 2 frequency bands at 1–100 Hz and at 10 Hz–3 KHz. Using a script within Spike 4 acquisition system (Cambridge Electronic Design Ltd, Cambridge, UK), we computed the summated LFP from the low-passed signal and the poststimulus time histograms (PSTHs) from the high-passed signal, appropriately thresholded for spike extraction. Both PSTH and LFP were computed on 15 stimulus presentations.
The VSDs
A hermetic chamber was sealed to the skull over the cortex and filled with the staining solution, that is, 1 mg of VSD (RH795; Molecular Probes/Invitrogen, Carlsbad, CA) in 1.3 ml of artificial cerebrospinal fluid (NaCl 125 mM, KCl 2.5 mM, CaCl2 2 mM, MgCl26(H2O) 1 mM, NaHCO3 2.5 mM, NaH2PO4 1.25 mM, glucose 25 mM). The solution was left on the cortex for 2 h and then removed. A photograph of the recording area was taken with a CCD camera. The recordings were made using a hexagonal photodiode array (H469-IV; WuTech Instruments, Gaithersburg, MD) containing 464 detectors and covering approximately 20 mm2 of cortical surface. The cortex was illuminated with a green light (centered on 520 nm), and the signal emitted was recorded through a red filter (600–660 nm). Because the signal was very sensitive to movements of the brain caused by heart pulsation and respiration, stimulus presentation was synchronized with the electrocardiogram signal, and the artificial respiration was stopped for about 3 s during each stimulus presentation. This caused an increase of about 1% in expired CO2 within a block of stimulus presentations (below).
We recorded 6 repeats of 4 different stimuli settings (center stimulus + 2 interactions between peripheral and central stimulus + background; see below), which resulted in a block of 24 recordings in about 15 min. A total of 5 blocks of recordings were performed with 7 min resting between blocks. All recordings were visualized using in-house software written by Dr Akitoshi Hanazawa on Darwin XFree86 (Roland et al. 2006). The first 3 blocks (12 recordings for each visual stimulus setting) were chosen for averaging because the signal was not yet attenuated by bleaching of the dye. These blocks were averaged, and the average of background recordings was subtracted from the stimulus recordings to eliminate artifacts caused by heartbeat. The resulting images were colored for VSD signal amplitude with the color scale normalized between the baseline level (green) and the highest value (red). Only recordings with stable baseline activity and free of heartbeat artifacts were used for further analysis.
Visual Stimuli
The pupils were dilated (1% ophthalmic atropine), and contact lenses were placed over the eyes. Using a reversible ophthalmoscope, the positions of the optic disks were marked onto a translucent tangent screen placed at 57 cm from the eyes. Stimuli were either hand moved on the translucent screen or generated on a 120-Hz refreshed monitor (Sony Trinitron Multiscan 17seII) placed at the same distance. The latter were 1.5-deg squares. Stimulus duration of 50 ms was chosen in preliminary experiments as the best compromise between the amplitude of the response and its temporal resolution. Luminance of stimulus was 120 cd/mm2 and background 30 cd/mm2.
At the end of the recording session, the animals were sacrificed with a lethal dose of pentobarbital sodium (120 mg/kg; intravenous) and perfused with 1 l of saline followed by 1 l of 4% paraformaldehyde in phosphate buffer. The brain was extracted and postfixed in 4% paraformaldehyde overnight at 4 °C, cryoprotected in 30% sucrose in 0.1 M phosphate buffer at 4 °C for 2 days, and cut parasagittally on a freezing microtome at 50 μm. Alternate sections were stained for cytochrome oxidase or 1% cresyl violet to identify the recorded areas (as in Innocenti et al. 2002).
Experimental Design
In an initial series of experiments, we determined the width of the visual field represented in both hemispheres and the role of input from the contralateral visual areas in the representation. In 2 animals, 3–4 anteroposterior rows of penetrations, crossing the 17/18 border and area 18, spaced at 1.5 mm from each other, were performed in each hemisphere; within each row, the recordings were spaced at 500 μm. The position of the zero vertical meridians (i.e., the central border of the hemifield representation) for the left and the right eye were marked on the screen. The electrophysiological signal was amplified and filtered, visualized on an oscilloscope, and played through a loudspeaker. Receptive fields were outlined by hand by moving a bright circle or bar across the screen (as in Manger et al. 2002). In 2 additional animals, recordings were performed only in the right hemisphere, and lesions of striate and extrastriate areas were performed by aspiration of the gray matter in the left hemisphere. The histological analysis of the brains confirmed the extent of the lesions. We remapped the visual field in the right hemisphere repositioning the electrodes at the locations recoded before the lesion and compared the maps before and after the lesion.
To determine the physiological properties of the visual field midline, in 7 experiments, we studied, in the right hemisphere, the CRFs either with VSD or by reconstructing the distribution of LFPs recorded at different cortical locations. We used triplets of monocularly presented stimuli whose positions were systematically shifted across experiments within the central 20 deg of the contralateral visual hemifield. Triplets consisted of a center (test) stimulus and of 2 additional (conditioning) stimuli falling on its right or on its left, at 4-deg center-to-center separation. Each stimulus was presented alone, and then the center stimulus was preceded by presentation of the stimulus to its left (i.e., more peripherally in the same hemifield) or to its right (i.e., more central in the same hemifield) at 100-ms interstimulus interval. The position of the screen was adjusted so to place the stimuli near the visual midline, and their precise location was verified by mapping the visual field representation at the end of the experiment (as in Manger et al. 2002).
To study the PRFs, that is, the portion of the visual field from which responses can be obtained at a single electrode site, in 3 experiments, we recorded the responses to stimuli flashed at different locations in the visual field. A center (test) stimulus (same size, duration, etc., as above) was either presented alone or preceded by conditioning stimuli with the same characteristics but placed at 2°, 4°, 6°, or 8° above, below, on the right, or on the left of the test stimulus. The conditioning stimulus was presented 8, 25, 50, 100, or 200 ms before the onset of the test stimulus. We also recorded the response to the conditioning stimuli alone.
Bihemispheric Representation of the Visual Midline in the Ferret
A total of 110 recordings were performed, evenly distributed between 2 animals and hemispheres, and the minimal response fields for each eye were mapped at each location (Fig. 1). A binocular, 8- to 10-deg-wide vertical strip of the visual field is represented in both hemispheres. This bihemispherically represented strip of visual field is narrower than the callosally connected portion of the retinotopic maps in areas 17 and 18. This reaches as far as 20 deg of visual field, based on the retinotopic location of cell bodies of callosally projecting neurons and of callosal terminals. However, a fraction of neurons with receptive field centers beyond 10 deg from the zero meridian falls in acallosal zones. This fraction increases with eccentricity, from 10% at 10-deg azimuth to 100% at 50 deg (see Fig. 10 in Manger et al. 2002). In 2 experiments (data not shown), the minimal response fields near the vertical meridian were mapped before lesion of the contralateral areas 17–19 and then remapped after the lesion. All the receptive fields that were mapped before the lesion could also be mapped after the lesion. Therefore, we postulated that the corpus callosum (CC) might not provide a strong "driving" input to the contralateral hemisphere in the intact animal, although it does in the split chiasm preparation (Berlucchi and Rizzolatti 1968; Lepore and Guillemot 1982).
Properties of Responses Elicited from the Midline of the Visual Field
The position of the stimuli was systematically shifted across experiments (Fig. 2). Based on the results above, we expected stimuli falling in the peripheral 10–11 deg of the visual field to be processed in the contralateral hemisphere and those falling in the central 10 deg to be processed in both hemispheres with the medialmost stimuli, processed perhaps prevalently in the hemisphere contralateral to the recordings.
CRFs Visualized with VSD
The dynamics of the VSD/CRFs are shown in Supplementary Figure 1 and in Figure 3. The responses begin about 40–50 ms after the stimulus onset as an irregularly elongated spot of activity about 1 mm in its maximal diameter, oriented perpendicular to the 17/18 border. They progressively expand during the subsequent 40–50 ms to reach their maximal diameter of about 1.5 mm perpendicular to the 17/18 border and 1.1 mm parallel to it. They maintain the same diameter for about 40 ms to shrink again to their initial location in the next 80 ms and have disappeared at about 250–300 ms after stimulus onset. Comparison of the responses elicited from the central (right) and peripheral (left) stimuli (Supplementary Fig. 1) showed that the CRFs activated by the 2 stimuli overlap extensively, particularly at the peak of activation. However, the response to the first stimulus is centered slightly posterior to that for the second stimulus. Therefore, the stimulus closest to the midline activated posterior area 18 and the adjacent area 17, and the other stimulus activated anterior area 18 and perhaps area 19, in agreement with the known topographical organization of the 2 areas (Manger et al. 2002). In most experiments, the expansion of the CRF was greater parallel than perpendicular to the 17/18 border, and so was the speed of expansion, with across-experiment variability (range of 8 measures 8.7–133 μm/ms).
The CRFs to the test stimulus were depressed by a preceding conditioning stimulus. In the example shown in Figure 3, the response to the center stimulus began at about 50 ms after stimulus onset (at 200 ms) and continued for about 200 ms (up to 440–460 ms). When preceded by the conditioning stimulus, the 2 CRF initially merge (at 260 ms), but then the CRF to the center stimulus is powerfully depressed. The depression might actually improve spatial and temporal resolution of the response because the CRF elicited by the center stimulus shrinks and its duration is decreased to about 100 ms. The depressive effects were qualitatively similar in the 2 experiments in which the stimuli spanned the greatest azimuth (0915 and 0820; Fig. 2) and were also similar when comparing the effects of the most peripheral stimulus ("left" stimulus in 0820) with that of the most central stimulus ("right" stimulus in 0915; Fig. 2).
Because in the experiment 0915 the right (central) stimulus evoked a very weak CRF, the findings indicate that the magnitude of the depressive effect is independent of that of the CRF recorded at the same location. The depressive effect might originate from the activity of neurons far away, that is, in the contralateral hemisphere.
VSD/CRF and microelectrode recording sites are superposed in Supplementary Figure 2, and the VSD signal, LFPs, and PSTH of multiunit responses are shown for each microelectrode location. The 3 types of response are usually elicited by the same stimulus, but the VSD response can be seen at cortical locations lacking PSTH response and, occasionally, the LFP response (Supplementary Fig. 2). LFP responses can be observed in the absence of PSTH responses (Supplementary Fig. 2), suggesting differential sensitivity of the 3 methods, with the VSD being slightly more sensitive than the LFP. The VSD response consists of a single upward signal (normalized as explained in Materials and Methods) lasting about 200–300 ms, depending on location, and essentially damping the oscillatory component of the LFP (described below). The peak of the PSTH precedes that of the LFP by 10.1 ± 3.1 ms (P < 0.01) and the peak of the LFP precedes that of the VSD by 23.4 ± 7.0 ms (P < 0.01) (t-tests).
CRFs Visualized with LFPs
The results of the VSD experiments conducted with the VSD RH 795 appeared not to be amenable to a more detailed quantitative spatiotemporal analysis. Instead, this was possible with the LFP responses.
Figure 4 shows location and dynamics of LFP/CRF to stimuli flashed at different azimuths in the same experiment shown in Supplementary Figure 1. LFPs typically consist of a first negative peak lasting about 100–120 ms, followed by a longer positivity lasting 150–200 ms. At some locations, the negative potential consists of 2 incompletely separated peaks corresponding to "on" and "off" stimulus components. Plotting together the responses to the same stimuli obtained at different locations shows that the negative peak of the response CRFs begins at 25–30 ms after stimulus onset and expands in the subsequent 20–30 ms to cover a territory 1–1.5 mm2. It shrinks in the subsequent 80 ms and is replaced by the positive component of the LFP lasting up to 300 ms after stimulus onset. The amplitude of the response is largest near the CRF center and decreases toward its periphery. The topography of the CRF is compatible with the retinotopic organization of areas 17 and 18 (Manger et al. 2002) and with the VSD findings. The stimulus, which lies more peripheral in the contralateral visual hemifield, activates area 18 anteriorly, whereas the more centrally located stimulus activates area 18 posteriorly, extending into area 17.
To clarify how the CRFs change with stimulus position, amplitude and latency of the negative LFP peak evoked by each stimulus were averaged across their CRFs in areas 17 and 18. The values obtained were subdivided in 5 stimulus azimuth bins from 0 deg, corresponding to the estimated border of the region of bihemispheric representation, to 16–20 deg in the contralateral hemifield. The mean amplitudes and latencies across experiments at each azimuth were entered in Figure 5. The amplitude of the negative peak of the response drops by 50% from stimulus locations at 12- and 16- to 20-deg azimuth to those at 0 deg. The latency of the response peak increases from 46.7 to 60.3 ms over the same azimuth span. LFPs to stimuli within the central 0–8 deg of visual field have significantly longer latencies than those for stimuli at 12–20 deg (t-test; P < 0.003). The significance of latency differences between the LFPs to right and left stimuli in the individual experiments tends to increase approaching the visual field midline (t-test; P < 0.2 for experiment 0909, P < 0.08 for 0904, and P < 0.04 for 0915).
The interaction between the peripheral (conditioning) stimuli caused depression of the negative component of the LFP response to the center (test) stimulus at 112 and facilitation at 42 microelectrode locations. An example of depressive interaction on the LFP/CRFs is shown in Supplementary Figure 3. When the center stimulus is preceded by the conditioning stimuli, the response is strongly depressed at 50 ms after stimulus onset and is completely replaced by the positive LFP component already at 70 ms.
Figure 5 shows a weak tendency to a decreased depression with test stimuli approaching the visual field midline. However, the differences in the magnitude of the depression caused by conditioning stimuli central or peripheral to the test stimulus in the 2 experiments in which they spanned the greatest azimuth (0915 and 0820; Fig. 2) were far from statistical significance (P < 0.16; t-test, n = 40). Equally nonsignificant were differences in the depression elicited by the left stimulus in the experiment 0820 (the most peripheral stimulus across experiments) and by the right stimulus in 0915 (the most central stimulus across experiments; P < 0.36; t-test, n = 40). Finally, in the experiment 0915, the central and peripheral stimuli significantly differ for latency and amplitude of the LFP but not in their interaction with the test stimulus (P < 0.11; t-test, n = 40). (These results also imply that the size of the depressive effect is independent from that of the negative (excitatory) phase of the LFP. Indeed, no significant correlation was found between the 2 across the entire set of the present data. We then investigated if proportionality existed between the size of the depressive interactions and the latency of the LFP, but none was found. There was also no significant correlation between the latency of the LFP and its amplitude. To explore further, the relations between latency/laterality of the LFP responses and magnitude of the depressive interaction, the results were divided in 2 groups according to whether the latency of LFP to the central stimulus was larger or smaller than that to the peripheral stimulus. This resulted in 2 groups of locations with highly significant latency differences (52.3 and 62.9 ms), but there were no significant differences in the magnitude of the interaction with the response to the test stimulus, nor with the size of the LFPs. Together, the results described seem to confirm that the suppressive effects are triggered from far away neurons as confirmed in Makarov et al. Forthcoming.)
The facilitatory interactions between stimuli appear to relate to the size of the LFP response to the center stimulus. Indeed, while the large responses are invariably depressed, some of the small ones are facilitated (data not shown).
PRF Near the Vertical Visual Field Midline
The fact that amplitude and latency of the responses differed in the central versus more peripheral portions of the visual field could be due either to properties of the callosal connections or to the spatiotemporal structure of the PRFs (i.e., the portion of the visual field from which responses can be obtained at a single microelectrode position) in the callosally connected region near the 17/18 border. The latter was investigated by recording the responses to 1.5-deg square stimuli, flashed in a random sequence for 50 ms, in 2-deg steps along the 4 arms of a cross extending as far as 8 deg from a stimulus centrally located in the PRF. Responses (PSTHs or LFPs) were recorded at 15 locations, in the right hemisphere, within the central 10 deg of the visual field, in 3 ferrets.
At any given cortical location, amplitude and latency of the LFP response varied with stimulus eccentricity (Figs 6 and 7). The amplitude of the response negativity was maximal near the center of the PRF and progressively decreased away from it, usually disappearing at 8 deg, whereas the positivity could have a broader span. The amplitude of the LFP also depended on depth in the cortex, being maximal near the layer where, as a rule, recordings were performed (Fig. 7). The latency of the negative peak increased with eccentricity from 46.3 ms near the PRF center to 53–60 ms at 8 deg in the periphery. There were small (6 ms on average) nonsystematic variations of response latency with depth in the cortex.
To determine if stimuli interacted differently depending on timing and position within the PRFs in 5 experiments (12 locations; right hemisphere), we studied how conditioning stimuli flashed at 2-, 4-, 6-, or 8-deg separation central or peripheral to a center stimulus modified the response to the latter. The center stimulus was, as above, placed in the center of the PRF, within the 10-deg portion of the visual field with bihemispheric representation. The interval between conditioning and test stimuli was of 8, 25, 50, 100, or 200 ms. The conditioning stimuli either enhanced or depressed the response to the test stimulus depending both on the angular and temporal separation between the stimuli. The strongest and clearest interactions were seen with 2- to 4-deg separation between stimuli and attenuated with larger stimulus separations (Fig. 7). The facilitatory effects dominated at interstimulus time intervals of 8 ms (55% of cases), whereas with time intervals of 25–200 ms depressive effects predominated (84% of cases). No consistent differences related to whether conditioning stimuli were central or peripheral to the test stimuli could be demonstrated.
Mapping Visual Responses with VSDs and LFPs
The CRF and the PRF responses we recorded are closely related, respectively, to the "point image" introduced by McIlwain's (1975) retinocollicular studies and to the traditional receptive fields of visual electrophysiology. However, because they are based on the analysis of VSD and LFP signals instead of single units, they achieve a lower level of spatial resolution and higher sensitivity. These properties help in understanding if some features of the responses recorded near the midline of the visual field might be due to callosal connectivity.
The VSD/CRF dynamics in the ferret visual areas are similar to those reported in other sensory systems and/or species. The responses, started at about 40 ms after stimulus onset, reached their maximal expansion 40–50 ms later, to return to baseline in the following 150 ms. Similar dynamics were reported for the monkey area 17 (Grinvald et al. 1994; Slovin et al. 2002), for the visual areas of the ferret (Roland et al. 2006), and for the barrel field of the rat (Petersen et al. 2003). In both monkeys and ferrets, the activity spread faster parallel than perpendicular to the 17/18 border. Because the retinotopic magnification factor in the ferret is larger parallel than perpendicular to the 17/18 border (Manger et al. 2002), the CRF expansion might actually be radially symmetric in visual field coordinates.
We noticed 3 differences between the VSD and LFP responses. First, the LFP peaked about 20 ms before the VSD. This latency difference might in part be due to delays between the responses in layer 4, where the LFP was recorded, and the summated depolarization of the distal portion of the apical dendrites, which probably constitutes the main component of the VSD (Grinvald et al. 1994). Also, the VSD responses did not show a sign reversal corresponding to the negative–positive components of the LFP (as in Grinvald et al. 1994; but see Derdikman et al. 2003). Finally, the VSD signal spread horizontally further than the LFP signal, at least with the number of stimulus repetitions used in the present experiments, which was chosen to minimize volume conduction artifacts.
The CRF expansion appears to be due to activity spreading along the tangential collaterals of layers 2 and 3 pyramidal neurons (Grinvald et al. 1994; Petersen et al. 2003). However, we found that at a given cortical site the responses from the periphery of the PRF can be delayed by about 20 or more milliseconds, compared with the center, a finding resembling the center–periphery receptive field delays in the response of V1 neurons in the monkey (Rossi et al. 2001). Therefore, center–periphery delays in the PRFs can contribute to the different responses latencies within the CRF. The relative contribution of local connections, feedback cortical connections (Angelucci et al. 2002) or subcortical mechanisms, will have to be dissected by ad hoc experiments.
Some Properties of the Cortical Representation of the Visual Midline
Microelectrode recordings showed that a central 8- to 10-deg-wide strip of the retina is represented in both hemispheres in the ferret. This strip includes the central vertical meridian of the binocular visual field; therefore, 4–5 deg of the ipsilateral visual field, between the zero meridian (here defined as in Manger et al. 2002) and the central vertical meridian, are represented in each hemisphere. This is less than what was obtained by imaging the intrinsic optical signal (about 10 deg; White et al. 1999). Mapping the minimal response fields might have underestimated the degree of overlap, whereas imaging might have overestimated it, by showing subthreshold activity relayed across the CC. From retrograde transport studies, the nasotemporal overlap of the receptive field centers of ganglion cells, in the ferret retina, was estimated to be about 5 deg (Morgan et al. 1987).
In preliminary experiments (data not shown), lesions of the corresponding contralateral visual areas did not modify the ipsilateral visual field representation along the 17/18 border (as in the cat; Leicester 1968; but see Payne 1990). Also, inactivation of the contralateral hemisphere depressed but did not eliminate the responses of neurons in areas 17 and 18 (Payne et al. 1991). In contrast, callosal transection eliminated the representation of the ipsilateral visual field in area postero medical lateral suprasylvian of the cat (Marzi et al. 1982).
The visual field midline showed some unexpected properties. The amplitude of the LFP responses progressively decreased approaching the zero meridian within the central 10–15 deg of the visual field, whereas the latency progressively increased. The latency difference of about 14 ms between the responses elicited from near the zero meridian and those evoked by more peripheral stimuli is compatible with the conduction delays along callosal axons (Innocenti 1986). This is how comparable delays were interpreted in man (Rugg et al. 1984; Saron and Davidson 1989; Brown et al. 1998) because the response to ipsilateral stimuli is lost in acallosal or callosotomized subjects (Rugg et al. 1985; Brown et al. 1998). However, those responses were recorded from lateral occipital or parietal electrodes, and therefore, they may not reflect the activation of the primary visual areas. As mentioned above, the contribution of callosal connections to the responses in these areas might be stronger than in the primary areas.
Perceptual peculiarities across the visual midline were tentatively ascribed to less effective interhemispheric than intrahemispheric processing. Cognitive (Kanizsa type) contours are less effectively completed across than within the hemispheres (Pillow and Rubin 2002). Waves of interocular rivalry are delayed by about 173 ms, when crossing the visual midline (Wilson et al. 2001). More relevant to the present work, visual stimuli flashed sequentially at the corners of a square centered on the visual midline are perceived as apparent motion along the vertical rather than along the horizontal (cross-hemispheric) direction. Although this could be interpreted as due to the conduction latency introduced by callosal connections in the horizontal direction, similar results were obtained in callosal-split patients (Ramachandran et al. 1986; see also Gazzaniga 1987; Naikar and Corballis 1996). Our interpretation is that they may be due to the longer response latencies near the midline.
Increased processing latency to stimuli presented near the visual field midline was reported in man (Carrasco et al. 2003). These findings were explained as due to the increasing proportion of magnocellular ganglion cells in the retinal periphery demonstrated by Azzopardi et al. (1999) in primates. A similar explanation may apply to the ferret, but we propose an alternative/complementary possibility. Retrograde fillings in the ferret showed a substantial drop of ganglion cell density near the line of nasotemporal decussation (Morgan et al. 1987). Therefore, the contribution of retinogeniculate PRF center-to-periphery gradients to the responses probably increases approaching the zero meridian. As the responses become progressively dominated by the peripheral portion of the PRFs, their latency can be expected to increase and their magnitude to decrease. Indeed, we observed increased latency and decreased amplitude of the responses with increasing distance of the stimulus from the PRF center.
The interpretations above suggest that callosal connectivity, rather than causing peculiar neurophysiological and perceptual phenomena along the visual field midline, may just fail to modify features of the cortical response caused by the properties of retino-geniculo-cortical input. Possibly, the discrete, short-lasting stimuli used here are not processed by interhemispheric interactions. This unexpected conclusion was confirmed in the companion paper that showed lack of callosal transfer for similar stimuli (Makarov et al. Forthcoming).
The depressive interactions between spatially and temporally contiguous stimuli might partially compensate for the functional heterogeneity of the visual field because they seem to be relatively independent from central–peripheral gradients and interstimulus delays (Figs 5 and 7). Depressive/inhibitory interactions between neighboring stimuli with high contrast (as those used here) falling in the same hemifield have been well documented (e.g., Toth et al. 1996; Chen et al. 2001). Callosal connections can mediate comparable inhibitory interactions between hemifields/hemispheres (Innocenti 1986; Hughes and Peters 1990; Payne et al. 1991; Desimone et al. 1993; Makarov et al. Forthcoming).
Supplementary Material
Supplementary Figures 1–3 can be found at: http://www.cercor.oxfordjournals.org/.
European Community research (contract APEREST); the Swedish Research Council (contract K2002-33X-12594-05B to G.M.I.); a Wenner-Gren Foundation fellowship and the Science Promotion, Culture, Sports, Science and Technology of Japan (Grants-in-Aid for Scientific Research C18591912) to H.N.
The authors are grateful to Professors Akitoshi Hanazawa and Per Roland, for their help in setting up the VSD laboratory and the analysis software, and to Sonata Valentiniene for her histological work and laboratory assistance. M.C. and F.K. were Erasmus Program students. Conflict of Interest: None declared.


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Guide: Document provides instructions to gain access to Intel® Manufacturing Advantage Services (MAS) collaterals with resources for new account registration and contact information for local Intel representatives.
Chen Han Lim demos a solution that collects machine data in a mobile app for manufacturing efficiency.
See how Intel's Corporate Quality Network (CQN) ensures only the highest-quality products go to market.
See how Intel uses knowledge-based qualification to qualify products in unique usage environments.
Step-by-step instructions for aligning Intel® motherboards and the I/O opening on a computer chassis.
Intel's ESD prevention methods prevent costly damage to electronic devices.
PoP device rework demos thermal reflow profile, PCB pad site, and new component preparation.


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Bestselling Beauty Buys Under Ł20
Update your beauty regime for 2016 with the Fragrance Direct Bestselling Beauty Buys, including our top ladies skincare, fragrance, haircare and bath and body lines. This collection of FD favourites includes brands such as Vera Wang, TIGI, Gucci, Stella McCartney, Nuxe and Elizabeth Arden. Shop Fragrance Direct's bestselling beauty buys all with great savings on high street prices and up to 70% off the RRP. Including classics perfumes like Sarah Jessica Parker Lovely and new brands to FD, such as Nuxe Skincare and Stendhal.


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Shadow Enemies; Hitler's Secret Terrorist Plot Against the United States
ABELLA, Alex and GORDON, Scott
Place Published: Guilford
Publisher: Lyons Press
Date Published: 2002
Description: Illus. 8vo, 1/2 black cloth, d.w. Guilford: Lyons Press, (2002). Very goodEdition: First
Jacket: Y
Binding: hardcover
Condition: very good
Language: English
Type: Books
Book ID: 244301
By This Author: ABELLA, Alex and GORDON, Scott
By This Publisher: Lyons Press


text:
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Portage has a population of and is located in county.
The average in-state tuition for full time undergraduate students in teaching schools in Portage during the 2009 - 2010 school year was $22,360.00. The average tuition was $22,360.00 for non-residents studying in Indiana.
The cost, on average, for books and supplies needed for teaching schools in Portage is $1,500.00. There is one teaching college in Portage for students to choose from. In the 2008 - 2009 school year, reportedly 3 students completed teaching programs in Portage.


text:
Magic Fluke Company
292 South Main Street, Sheffield, MA 01257
0 people saved this
Factory outlet for Fluke, Flea and Firefly Ukuleles made right on premises. Accessories, seconds and lessons available. Mon-Fri, 9-4pm.
New England Patriots, For the Win!
The debate is over - Thomas Edward Patrick Brady Jr. is the greatest NFL quarterback...
Search All Listings Here.


text:
All new Episodes and Movies will now become available for free, with NO ADS on youWatch.pro, take a look!
Supernatural S03E02
|Watch Online Supernatural: Season 3 Episode 2 (S03E02) Stream
The Kids Are Alright
Plot: A strange death reported in the newspaper prompts Dean and Sam to find Lisa Braeden, a woman Dean had a weekend fling with about 8.75 years ago, only to find she has a son turning 8. While investigating the death in the paper along with several other mysterious recent deaths, Sam and Dean find they are chasing a Changeling, who is replacing children with it's offspring. The mysterious blond woman is back, giving Sam a cryptic message that he should look into his mother's friends.
Video Links Server Name Language Quality


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TT News Agency is the national wire service in Sweden with a history dating back to the 1920's. TT News Agency delivers text, images, video and graphics to Sweden's media outlets, companies and public authorities.
The agency's mission has always been to convey fast, impartial and reliable news to the media market. A wide range of services have been added over time: images feature packages, interactive info graphics, news video TV clips, design services and a 24/7 news update-service for digital platforms. Via TT is our new pressrelease system to be used by press and marketing organisations.
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The images of Lennart Nilsson
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text:
Being the record of an expedition to locate
and capture an iceberg seen to be somewhere off
the coast of the South Island last seen buried deep
within Freemans Bay
Though this novel is set very much in the present the beginnings
of the Auckland art market are also there. The reader is dropped
into the 1960s and even further back into the infinitely hospitable
culture of shared flats in an old mansion in St Mary's Bay and a shed
by the water that when the door opens looks as if a tidal wave has swept
debris inside. It's a mere hint of the dire situation the inhabitants
of earth are in, not described but penetrating the saga and the wonderings
of the adventurers as they sail off to catch that elusive iceberg.
This is a novel populated with artists, poets and boat builders all living
their craft as inner necessity, loyal, loving, and suspicious of one another
by turns as they set off together on surreal adventures.
And who is the protagonist? Eventually the connections become apparent through
the riffs of anecdotes and haze of narcotics, for nothing is explained
or commented on but casually and intensely recounted by the one who is keeping
a logbook from the moment he meets his mentor, the mysteriously named Troon.
First published last year in a small print run this book has attracted a growing
number of readers who delight in its quirky humour and exuberant language
while appreciating the serious themes and rich depth of experience that informs
this 'voyage'.
"...The freshness of Something Else - besides Sally Griffin's lovely,
expressionist illustrations at the head of each chapter - is that it tells
a story from our recent history that has seldom been told....
New Zealand Books
David Parkyn takes a unique blend of art theory, maritime camaraderie
and a touching story and combines them elegantly....
BOOK SHOPS 'Something Else' is distributed in New Zealand by Nationwide Books Distributors
T: 0800 990 123 W: nationwidebooks.co.nz E: firstname.lastname@example.com
PIEDOG PRESS PO Box 10-265, The Terrace, Wellington 6143 New Zealand


text:
1.69 acres in Saint Johns County, Florida
This would make a very good location for a dollar general or a Quick Market.
2 Miles west of Hastings FL. Where County 207A runs into State Road 207 and there is an agency sign (large) on the property. Vacant land easily recognized.
Tax Data (Show Tax Data)
Tax data is not available for this listing.
Contact the Seller for more information.
Other Land for Sale in Saint Johns County
- Saint Johns County Properties by City
- Saint Augustine, FL Land for Sale
- Hastings, FL Land for Sale
- Elkton, FL Land for Sale
- Fruit Cove, FL Land for Sale
- Properties for Sale in Nearby Counties
- Clay County Land for Sale
- Duval County Land for Sale
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NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


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This action might not be possible to undo. Are you sure you want to continue?
Adam Fieled
Flaubert's two protagonists - F. Moreau and Emma Bovary - share the complexes of halfdeveloped interiority, oriented around systems of sensibility (hypersensuality) which struggle to achieve understanding. The double standards imposed by gender- that F. Moreau is sanctioned to attain his sentimental education while Emma Bovary pays for hers with her life - do not deflect attention from the essential similarity of this half-hollow core, which registers all facets of human life (affect, social responsibilities, the vicissitudes of different forms of attachment) on only the first, lowest level of cognition, sans the enhancement of a higher mind to grant the form of principles leading into any kind of settled wisdom, against currents which bear them along, rising and falling, in a world only detailed on the surface, and then only by the formal delicacy and exquisite precision of Flaubert's prose. Flaubert's didacticism - his lesson for discerning readers - is a kind of treatise on what constitutes "missing interiority" in average, undistinguished human consciousness. The disjuncture between what the narrative third-person eye sees - an ornately detailed, finely wrought and structured set of interstices and connective tissues, fastening and clasping figures tightly to a world configured past evanescence - and what F. Moreau and Emma Bovary see - a mirror-reflection of a landscape formed to affirm or deny their claims on sociosexual and socio-cultural desirability, to (figuratively) nod at them in affirmation of their claims, which they react to with conventional pleasure or displeasure (acceptance engendering pleasure and rejection displeasure), makes clear the author's (perhaps alienated) distinction from his protagonists, his own comprehensive understanding of their circuitry dynamics from "over" them, leading back to the guiding principle of missing interiors, and its strange (uncanny) chiasmus with finely interwoven hypersensual detail, how it generates textual richness against the impoverished cognitions and inchoate misunderstanding of these characters. Thus, dealing with these texts, hypersensuality on one proverbial hand and missing interiors/interiority on the other generate a tension-and-release dynamic- the detailing, in all its tactile richness, releases readers from our limited ability to affix attention to/"bind" to protagonists whose pedestrian perceptions, motivations, and situational improvisations must be a disappointment to us. In a way, this chiasmus demonstrates Flaubert's form/manner of negative capability- the polarity of hypersensuality/missing interiority is not only never resolved, it inheres so dynamically and seamlessly in these texts that it creates its own
form/manner of textual ambience, extraordinarily unique in the annals of major high art consonant prose, and gilded with levels/layers of richness against his own protagonists, who are radically diminished by what they cannot, with their merely sensible cognitions and lack of understanding, surpass. Sensory data is not merely drawn, it is important to note, from nature- the synthetic materials of human life (houses, faces, clothing, food) are all drawn into the scaffolded matrix of Flaubert's regulatory and compensatory hypersensuality, so that the hypersensual textual impulse, as it were, is not strictly anti-human/Other in the conventionally (English) Romantic manner.
As to the significance of the hypersensuality of Flaubert's prose, in the ultimate sense - and what might be called the ultimate Flaubertian mystery - it would seem that it reduces to one suggestion, which bridges the physical and metaphysical, cognition and antithetical lack thereof - the raw fact and facticity of human life consists of the surface of human consciousness (sensibility) and, for most (all but a privileged few), the depths (cognitive or affective understanding, then understanding into the principles of reason) are an afterthought. The Flaubertian mystery involves the details and nuances of what I call the hypersensual (in the broadest sense, the ocular) and how (somewhere) the superabundance of sensual detail inhering in human life both redeems and vindicates all that is vapid and vacuous in the ever-developing continuum of human society, both what it engenders both in individuals and communities, and the manner in which it imposes itself on attempts to elevate, demystify, broaden, and educate broad swaths of population at different moments and through various epochs of human history. In other words, that there is a depth and density, angled against the vapid, to ocular surfaces, so that what they reveal is a kind of value or value-factor which varies in its manifestations from context to context, but grants permanent cognitive significance by revealing (in details, in nuances) what is unconscious or subconscious in the human race, which cannot (in these details/nuances) hide itself - thus, the ultimate Flaubertian mystery is an objective (third person) revelation of human depth from changing, scintillating surfaces. This Flaubertian mystery is obscure, tangled, confused - and other facets of the surface of Flaubert's prose (cynicism, irony, corrosive insight, revelations of cognitive-affective hollowness) are enjambed against it in such a way that the redemptive can manifest only intermittently. The dialectic between redemptive and corrosive narrative vistas in Flaubert manifests its syntheses in presence, the presence of present textual moments - and neither of the two threads is ever lost entirely against the other - so that not only is their synthesis perpetual, the perfected formal balance of Flaubert's impressively omnipotent third person voice weaves a textual tapestry both tightly and ornately enough that this formality is itself a mystery as dazzling in its array of combinations and effects as the mystery of Flaubert's hypersensual detailing and engraving. Thus, one seeming deficit of Flaubert's efforts when set alongside Tolstoy's - the half-present interiority of his protagonists, which drains narrative interest from their interior and exterior experiences - forms an unexpected synthesis of its own with Tostoy-as-antithesis, by adding a hinge to the most major high art consonant productions of representational art, its colors, forms, textures. Flaubert's prose is, indeed, more "colored" than Tolstoy's, and also more unique in its formulated strategies and
symmetrical angularities, cleaving to two representational centers rather than one, and making an indirect assaying of depth rather than investigating Tolstoy's probing, piercing, sustained directness. In "Anna Karenina," only the scenes delineating Levin's maintenance of his farm approach Flaubert's probing, piercing, sustained (and often pure, negatively capable) ocularity. If the peak exceeds the most intense moments of Flaubert's prose, owing to Levin's fullness as a character, is a worth an interrogative glance- as is the nature and complex of what the ultimate Tolstoyan mystery is.
Compressed Matrix : Flaubert and the Purification Chain
Primary Mode
(Space Between)
Secondary Mode Textual inclusions The "ocular" Hypersensuality (apotheosis of sensibility) detailed prosody "value-factor" of the representational/painterly to purify partials with wholes : "depth of surfaces" sensibility-as-understanding
Textual elisions/half-elisions (quarter-elisions) Explorations of hollowness/ half-filled interiors and/or missing interiors/merely "sensible" protagonists third-person omniscience ("understanding") restrained prosody/no editorializing linear narrativity
Hypersensuality purifies explorations of missing interiors because, as a secondary mode of aesthetic expression, it vouches for hidden depths within the surface of raw sensibility, a sense of beauty and wholeness against the stunted and partial, and a sense of release from narrative tensions, strains, and abrasions. Hollowness and hypersensuality both maintain a formal and a thematic component – the formal quality of the one side's prose balances the others because "hollowness" in Flaubert's texts functions by a sense of deliberate elisions (elided editorializing/judgmental accusations/expanded interior glances) while hypersensuality functions by a deliberate sense of inclusion (details, the richness of active surfaces perpetually rendered.) Why Flaubert's linear narrativity, split between character-based elisions and ocular inclusions, is still a superior congeries of formal-thematic gambits to what the avant-garde twentieth century novel presented – that the formal and thematic elements are woven and "scaffolded" together in such a way that no obvious textual imbalances are created, which cannot be said of the Edwardians on one hand (whose formality lacked inventiveness) and the Modernists on the other (whose formality chewed up and swallowed most thematic elements in their texts); and that the twentieth century's rote insistence on the retrograde nature of linear narrativity was both reductive against what it might achieve when executed artfully and unwholesome/perverse in its overrating of the formalist textual impulse. Adam Fieled, 2014
***paintings in this pdf by Henri de Toulouse-Lautrec***


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Discussion in 'Professionally Qualified, RAMC and QARANC' started by dui-lai, Oct 2, 2006.
The heart of the site is the forum area, including:
See Current Affairs folks, both are RAMC
Also look at this one.
it's a very fast growing thread and worth a read.
rest in piece den,you had some sense of humour...R.I.P
Den, your humour and sarcasm were equal to none. You were proficient at your work and extremley well thought of by those who knew and worked with you. May you be in a place of happiness and our thoughts are with your family in their time of bereavement at the loss of their brave son.
Take care Den, you will always be in my memories!
To lose a soldier is bad enough, to lose one of our own words arent enough.
RIP brother
I last saw Den in Keogh back in '94 but still feel a tremendous sense of loss. This is a testament to his character and to how well liked he was. We had some laughs in basic and on CMT 3, memories that will saty with me forever.
RIP buddy.
When ever the muck and bullets are flying and your hear someone call "medic" you dont even think about it, you know that theres a guy running full tilt with little thought of his own personal saftey to get to the injured.
Thank God for Medics!
Been reading about Noel Chavasse VC and bar, MC whilst in hospital. What a story that mans life was!
I think RIP is getting a bit boring... Anyone who dons the uniform must be given a few lines of script before they meet the earth and worms.
It is better to have been someone for a day than no one for a life time. Den sleep easy and enjoy the rest as you truly deserve to lean on the pearly gates. May the the port flow freely and the HCA's be easy...rest easy up stairs.
So sad, really sad!
RIP Den
Lance Corporal Dennis Brady was hit in an "indirect fire attack" at the Shatt Al-Arab Hotel after mortars landed inside the UK base in Basra, southern Iraq, on 1 October.
The 37-year-old, from Cumbria, was a regular reservist from the Royal Army Medical Corps, attached to the 1st Battalion of the Light Infantry.
L/Cpl Brady grew up in Barrow-in-Furness, Cumbria, where he lived with his wife, Zoe.
He left the regular Army in 2004 and worked as a firefighter before volunteering to return to the military as a reservist.
His commanding officer, Lt Col Johnny Bowron, said: "His loss will be keenly felt, and the battalion has lost a trusted member and a real friend."
SOLDIER Dennis Bradyâs mum received birthday flowers from her son in Iraq the day before learning of his death.
And the Lance Corporal was just two weeks from coming home to Barrow when he was killed in a mortar attack.
LANCE Corporal Den Bradyâs wife is today mourning a man she says âdied a hero.â
Zoe Brady, 30, of Barrow, has been married to the 37-year-old Army medic for six years but they have been separated for some time.
They have no children.
Speaking exclusively to the Evening Mail, she said: âDen lived life to the full. He put 100 per cent into everything he did.
âHis death will leave huge voids with every body who loved him.
âWords cannot express how much he will be missed.
âHe died a hero.â
Does anyone know funeral details or if a memorial fund is being set up to help Den's family. Please PM me if there is.
CC personal message sent. MWD
Separate names with a comma.


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As of today, 9/29/2016, I have been at the shelter for 384 days :-(!
MEET VIPER AKA MR. HAPPY…… Viper is a medium size, goofy and sweet boy that has been waiting for his forever home, well, forever… through no fault of his. You see, Viper was abused in his previous life and though very happy to make a new adult human friend, he is very scared of children. He needs a home with older children or even no children.
Please do not confuse his name, Viper, with the personality of a snake (viper), the staff actually named him Viper because his sleek black coat shines like a new Dodge Viper (sports car). Viper has one blue eye and one black eye that makes for a very striking appearance. He is much more handsome than his picture shows him. Black dogs are very hard to photograph.
Viper is a charter member of P.A.W.S Breakfast Club. We have a volunteer that takes some of the longer term residents out for breakfast. It gives them a chance to spend part of their day out of a pen and become more socialized. Some have never ridden in a car or been through a McDonalds drive through window. They love it. If interested in being part of the Breakfast Club, talk to our Manager.
Call (580-332-5233) or write email@example.com for an application and more information on Mr. Happy or simply drop by between 11-6, M-F and 10-2 on Saturday.
Thank You!
Your message has been sent to Pontotoc Animal Welfare Society.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


text:
- Affiliations:
1 Department of Business Studies, Aarhus School of Business, Aarhus BSS, Aarhus University
2 Information Systems Research Group, Aarhus School of Business, Aarhus BSS, Aarhus University
- Subtitle:
- a new approach to business process innnovation based on enterprise information systems
- Abstract:
- Most organizations today are required not only to operate effective business processes but also to allow for changing business conditions at an increasing rate. Today nearly every business relies on their enterprise information systems (EIS) for process integration and future generations of EIS will increasingly be driven by business process models. Consequently business process modelling and improvement is becoming a serious challenge. The aim of this paper is to establish a conceptual framework for business process innovation (BPI) in the supply chain based on advanced EIS. The challenge is thus to create a new methodology for developing and exploring process models and applications. The paper outlines the process innovation laboratory as a new approach to BPI. The process innovation laboratory is a comprehensive framework and a collaborative workspace for experimenting with process models. The process innovation laboratory facilitates innovation by using an integrated action learning approach to process modelling in a controlled environment. The study is based on design science and the paper also discusses the implications to EIS research and practice
- Type:
- Journal article
- Language:
- English
- Published in:
- Enterprise Information Systems, 2007, Vol 1, Issue 1, p. 113-128
- Keywords:
- Enterprise information systems; Business process innovation
- Main Research Area:
- Social science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2007
- Scientific Level:
- Scientific
- 2185884366