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Posts Tagged ' Rock.in '
Indiaplaza unable to raise funding, about to ring down the curtainMonday, July 15, 2013 | Sonam Gulati | More »
Indiaplaza, one of the first e-commerce ventures in India, is in the final stages of pulling down the shutters, sources close to development told Techcircle.in. The e-commerce company is unable to raise any fresh capital and has also sent a notification to all its vendors for negotiating and settlin...
Rashi Varshney
Yet another e-commerce shutdown, it's premium apparel and accessories e-tailer Rock.in nowYet another player seems to have joined the list of e-commerce startups shutting shop. This time, it is a premium apparel and accessories e-tailer, Rock.in, a brand owned by Mumbai-based Rock In Fashions Pvt Ltd. Techcircle.in tried to contact Rock.in's co-founder Aashish Puri, but has not receive...
16 May, 2013 | More »
Nandana Das
Excl: Premium lifestyle e-tailer Rock.in raises Series A funding led by VC firm PartechMumbai- based Rock In Fashions Pvt Ltd, which runs premium e-commerce site for apparel and accessories Rock.in, has raised an undisclosed Series A funding led by Partech International, a venture capital firm based in France & Silicon Valley and chasing early & mid-stage investment opportu...
23 August, 2012 | More »


text: Posted November 30, 2007 With the doom and gloomers predicting so much snow across Minnesota, I headed out yesterday with my 10 yr old Britt.I will occasionally hunt ruffs in the snow, but they do start acting different once the snow falls.We hit an area north of town. It is pressured hard on weekends. Have not seen many grouse there this fall. Assumed this area to be down?Except for 15 degrees F, it could have been Oct 29th. Little more orange on me and an orange vest on the dog, but no muzzleloaders out ...The birds must have spent Ocotber somewhere else. In 2.5 hours of hunting we moved 15 ruffs in two walks. Took home two and could have shot a couple more, but I limit my take in "winter" to two birds per area per day. Missed a few on the second walk.Move slow. Birds were holding very tight - even with other birds flush. Dogs pointing ... shooting. Share this post Link to post Share on other sites

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The top 10 US boomtowns of 2016
December Rate Hike Assured, Yellen Faces Future Battles
Service Sector Slows; Labor Market Remains Resilient
Manufacturing Contracts, but Rest of Economy Hums Along
For Third Straight Quarter, U.S. CEOs Cautious on Economy
GDP Growth Raised for 3Q; Inventories May Weigh on 4Q
Weak Economic Data Cloud December Rate Hike Possibility
Inventories Hurt 3Q GDP, Domestic Demand Strong
Fed Policymakers Keep December Rate Hike in Spotlight
4 Ways Rising Interest Rates Will Affect Your Investments
When Will the Next Recession Hit?
Import Prices Point to Smaller Drag on Inflation
Stronger 2Q Growth Backs Case for Fed Rate Hike
Why the Federal Reserve Needs to Get Its Act Together
How Same-Sex Marriage Ruling Will Affect the Economy
Robust Consumer Spending Buoys Economic Growth Outlook
California's Drought and You: Are Higher Prices in the Wake?
Market Wrap: Stocks Leap as Wall Street Applauds Job Growth
Anemic Factory Data Point to Moderate Growth Bounce
Market Wrap: Weak Economy Sends Stocks Down
Economy Stalls in 1Q as Weather, Lower Energy Prices Bite
Market Wrap: Stocks Fall on Economic Data; Automakers Slip
Americans Want to Be No. 1 Globally, but Feel Second Rate
Fed Opens Door Wider for Rate Hike but Downgrades Outlook
U.S. Growth Cools in 4Q, but Consumer Spending Shines
Signs of Optimism Among Family-Owned Businesses
U.S. Growth Revised Upward as Businesses, Consumers Spend
Wholesale Inventories Rise Modestly in September
Rising Food Costs Eat into Consumers' Savings at the Pump
U.S. Trade Gap Widens, Factory Orders Fall in September


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Dance. Urban. UK
This week Drake shot the video for his recent collaboration with YG and Kim Kardashian showed off some behind-the-scenes shots from Fergie's 'MILF$' video.
Picture 12 of 24
The singer, who recently married NFL player Russell Wilson, has been slowly releasing more details about her fairytale UK wedding. Picture: Instagram
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Police in Durham Region say a 76-year-old man is dead following a stabbing in Oshawa.
The incident happened around 4:30pm on Sunday afternoon. Police say they were called to a residence on Carnaby Court.
Walter Sollows was transported to hospital where he later died of his injuries.
Police allege the stabbing happened as a result of an altercation between the victim and his 53-year-old son.
Clyde Sollows has been charged with first-degree murder.


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text: Aaaaahhhh sweeet Sat in my front room and it looks v. large and v. pretty. The picture qualty is superb I agree with others - it takes a little bit of getting used to as images are so sharp. I'm delighted And I got it for £1600 including a 5 year warranty from robertwhyteltd.co.uk in Glasgow hmmmmm... they're also doing the Sony reference (DVP900?) DVD player for £300!


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Wedding rings in Memphis
Found: 3 products← Back to category "Jewelry, decorations"
Engagement Rings
It's a special moment when a bride-to-be discovers the perfect engagement ring that she wants to wear for a lifetime. These special moments happen regularly at Accent Jewelers in Memphis. Choose from the largest selection in town; Over 1500 engagement rings on display; Or, select a loose diamon Read more
USA, Memphis
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|Astoria beyond the East River––by Momentcaptured1 via Flickr
apartment: pet-friendly, great sunlight, deep closets, newly refinished hardwood floors,
and just a two-block stroll from our current home. Unfortunately, when we followed up with the broker a few days later to stake our claim, the
place had already been rented. Real estate (including rentals) apparently moves
at the speed of light in New York City.
my lunch break (just browsing, I swear!), I saw it. Except for the price,
which shot up $100 in the past eight months, everything looked identical to the apartment we had our hearts set on last spring. Even
the broker representing the unit remained the same.
|We decided to leave Long Island City and move next door to Astoria-–by jlwelsh via Flickr
Knowing better
than to waste time deliberating this go-around, after a slick and
speedy viewing, we filled out an application that night and got approved two
days later. We signed the lease within a week, and went from the real estate
office straight to the local hardware store to get a second set of keys made. This was really happening.
Moving isn't fun anywhere, but in NYC, it has to be the most challenging due to logistics like parking, unloading, narrow hallways and elevators, and of course, the tiny apartments. As soon as we started the process, I knew it would be an
ad hoc operation. Our spur-of-the-moment decision had its drawbacks with little time to round up packing supplies and organize our mounds of stuff, not to mention the actual move itself.
I spent all of last week scrambling around town searching for spare boxes from liquor
stores (Union Square Wines
and Astor Wines & Spirits both said yes, with plenty of grace and zero
judgment). I collected stacks of the Village
Voice and amNY to wrap up our breakables. What began as an exciting endeavor in upgrading and upsizing, now became a packing frenzy.
|I scrambled and luckily found enough boxes—by jqgill via Flickr
At first I thought we might have too much space in our
big new home. Then, packing up everything the two of us had accumulated together
over the past three cohabitated years, I realized that we had too much stuff. I figured out what we needed and what we didn't.
do we have so many books," I asked my boyfriend. "And blankets? And pillows?" I
continued to ramble. "Why did you let me get a grill pan and an electric grill, a sauté pan and a cast-iron skillet?"
|Do we need a cast iron skillet?—by I believe I can fry via Flickr
packing tape later, we began schlepping our stuff over to the new digs. Asked
to pay for half of January up front, we cut our losses and stayed positive,
deciding to use the extra time and take advantage of the close proximity
between the two buildings and hand-delivering some of our fragile family
members. Did I mention we own nearly 90 plants?
|We love our greenery!–by taradsturm via Flickr
Plus, we got a great deal
from U-Haul. Rates remain low mid-month and then spike during the last few
days, so what a three or four-hour rate would cost during peak time, got us a
24-hour window. And at an additional cost of $1.29 per mile, we grinned when we
returned the truck with just two miles tacked onto the odometer.
from out of town and helped us on moving day. With four people working nonstop, we got all of our
stuff packed into the truck, hauled up three flights of stairs, and placed throughout our living room and bedroom in eight manic hours. We unwound by
heading over to Break Bar and Billiards to shoot some pool, and finished the
evening with coffee and dessert, at a longstanding Astoria staple, Omonia Café.
|Omonia will be one of our new hangouts-–by Mfotography via Flickr
we got through the emotional and financial stress of our big move together.
What's our next great scheme? We'll celebrate with a housewarming party, of course!
|Astoria, Queens is our new home–-by xbettyx via Flickr


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"yalaha bakery" Eustis Off The Beaten Path Tip by doug48
Eustis Off The Beaten Path: 2 reviews and 2 photos
this wonderful german restaurant and bakery is hidden in the tiny unincorporated village of yalaha near okahumpka florida. their german breads are baked on old world slab stone ovens. they offer very good german fare as well as european cakes and tarts. they also have live entertainment on saturdays. this is a very popular restaurant for lake county residents and tourists that can find it.
from eustis take SR 19 south past tavares to CR 48. take CR 48 west in the direction of okahumpka about three miles to yalaha.
Phone: 352-324-3366
Website: http://www.yalahabakery.com/
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Topical Group on Precision Measurement & Fundamental Constants
The Topical Group on Precision Measurement & Fundamental Constants is a subunit of the American Physical Society. Its objective is to serve as a focus for research related to investigating and testing the fundamental laws of physics and their underlying connections, determining fundamental constants, and developing and improving basic measurement standards, with special emphasis on the high precision experiments that are characteristic of such research.
How to Join the Topical Group on Precision Measurement & Fundamentals
How to Join the Topical Group on Precision Measurement & Fundamentals
GPMFC Events at the APS April Meeting
See GPMFC at the APS April Meeting
Congratulations to Our Newest APS Fellows
Congratulations to New Prize & Award Recipients
2017 Francis M. Pipkin Award
Jens Dilling, TRIUMF
News & Announcements
GPMFC Events at the April Meeting
GPMFC is sponsoring two sessions and one workshop at this year's APS April Meeting 2017.
View Events
2017 GPMFC Election
Congratulations to the newly elected incoming GPMFC officers: Susan Gardner (Vice Chair) and Members-at-Large Andrew Geraci and Alex Sushkov.
The May 2016 Newsletter is now available.
Read Newsletter
Upcoming MeetingsAPS March Meeting 2017
March 13-17, 2017
APS March Meeting 2018
March 5-9, 2018
APS April Meeting 2018
April 14-17, 2018


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Hope Powell, buoyed by the team changes that helped England to a draw against Germany on Friday, is set to leave Karen Carney, her star winger, out of the team to face Argentina in Chengdu today.
England must win to clinch a place in the Women's World Cup quarter-finals and Powell is likely to recall Eniola Aluko and Rachel Yankey, while retaining Alex Scott, the full back, on the right wing, with Kelly Smith dropping back into the No 10 role to release the attacking trident. That would mean leaving out Carney.
Powell's tactical changes unnerved Germany, who should beat


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Today's Devotional
Not about FameHow has Jesus changed your life?
Let's Make ItFacebook official!
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You are here: Identische Inhalte (Aktueller Treeview). News.
Business News [MT]
ARIS integrates a fail-safe module with direct current drives of the Nano + series
[10/01/2017] ARIS Stellantriebe offers a fail-safe version for classic actuatorsARIS integrates a fail-safe module with direct current drives of the Nano + series - Read more
Extensive competence for engines with current and future drive forms
[04/01/2017] Rheinmetall Automotive at this year's NAIAS in DetroitExtensive competence for engines with current and future drive forms - Read more
In tune with the times
[08/12/2016] Knorr-Bremse can look back on a very positive InnoTrans fair.In tune with the times - Read more
HAIMER and MAPAL sign partnership agreement
[06/12/2016] The clamping technology specialist from Igenhausen near Augsburg and the precision tool manufacturer from Aalen are bundling their competencies.HAIMER and MAPAL sign partnership agreement - Read more
Introducing the ORLAS CREATOR 3D Metal Printer
[01/12/2016] OR LASER unveils its new direct metal additive manufacturing platform and ecosystem, developed and designed for small and medium enterprises, at Formnext 2016Introducing the ORLAS CREATOR 3D Metal Printer - Read more
indometal 2016 returns
[14/10/2016] The third edition of the biennially-held indometal – international metal & steel trade fair for Southeast Asia, will be held from 25 to 27 October 2016 at the Jakarta International Expo. indometal 2016 returns - Read more
Upsetting and piercing press for ThyssenKrupp Rothe Erde
[01/09/2016] A convincing feature of the Siempelkamp press was the high degree of automation, a guarantee for highly efficient production.Upsetting and piercing press for ThyssenKrupp Rothe Erde - Read more
Urban mobility in Qatar
[24/08/2016] thyssenkrupp Elevator: More than 500 elevators and escalators will be supplied for the Doha Metro project's Red Line North, Green Line and two additional major stations.Urban mobility in Qatar - Read more
New infrared systems speed up car production
[22/08/2016] Fast homogenous heating saves time and valuable spaceNew infrared systems speed up car production - Read more
Financing is a success factor for small & mid-sized enterprises
[18/08/2016] 4th Industrial Revolution will require companies to invest billions around the worldFinancing is a success factor for small & mid-sized enterprises - Read more


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Key Education Photographic Language Development Cards; Early Learning Skills
Item # 901-JV35161
Model # KED44046
Not yet rated. Be the first toWrite a Review
- Early Learning Skills
- A great resource for teaching language skills to English Language Learners (ELL), special learners, and students in head start or Title 1 programs
- Available individually, in boxed sets or a convenient classroom set, these versatile cards are essential for building literacy skills in a variety of learning environments
- Classroom set includes 90 photographs of "People and Emotions", 275 photographs of "Nouns, Verbs and Adjectives", 227 photographs of "Early Learning Skills" and 32 resource guide cards
- Ages 4-8
|Product Information
|School Grade :
|Brand :
|Key Education
|Weight :
|2.10 lbs. per Set
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- Details
- Reviews
- Hotel Pick-Up
- Airport transfer
- Instant Confirmation
When making a booking, you will need to advise your flight details and your Salzburg City Hotel details. Your transfer will be confirmed within 24 hours of booking and you will be provided with a travel voucher to present to the driver.
It's that easy!
Don't forget to book your Salzburg Airport Departure Transfer for on your way home!
At time of booking, YOU MUST include the following flight and hotel details in the "Special Requirements" box:
- Airline
- Flight Number
- Departing City / Arrival City
- Arrival Time
- Hotel Name
- Hotel Address
Price is per person, based on 8 adults per car/vehicle.
Schedule details
Select a month to view a calendar of availability and departure details.
Pricing information
Click the link below to check pricing & availability on your preferred travel date. Our pricing is constantly updated to ensure you always receive the lowest price possible.
Airport to Salzburg (AM)
Code: AMASZG
Private transfer from Salzburg Airport to Salzburg city hotels. Flights arriving between 7:00am and 10:00pm
GBP8.61Pricing details
Airport to Salzburg (PM)
Code: PMASZG
Private transfer from Salzburg Airport to Salzburg city hotels. Flights arriving between 10:01pm and 6:59am
GBP11.20Pricing details
Pricing information
Salzburg Airport Arrival Transfer
- One way private transfer
- Hotel drop off
- Gratuities (optional)
- Excess luggage charges (where applicable)
- Confirmation will be received at time of booking
- The duration of transfers are approximate, the exact duration will depend on the time of day and traffic conditions
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- Adult pricing applies to all travelers
- Price is per person, based on 8 adults per car/vehicle
Cancellation Policy
If you cancel between 3 and 6 day(s) in advance of the scheduled departure, there is a 50 percent cancellation fee.
If you cancel within 2 day(s) of the scheduled departure, there is a 100 percent cancellation fee.
Traveler Reviews
Reviewed by: berry.family, August 2016
Excellent! Our flight was late - yet our driver was patiently waiting there with a smile!
Reviewed by: Barry L, United States of America, May 2016
I have not used Viatour for these services but instead went through my destination hotel to make these arrangements. I now believe that it is less costly if you go through Viatour. My driver showed up waiting for me with the sign.


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To commemorate this year's World Sickle Cell Day, Mainframe Film and Television Productions will partner with Sickle Cell Foundation Nigeria, Channels Television , and Silverbird Television to bring to Nigerians the award-winning edutainment movie, Dazzling Mirage directed by Tunde Kelani.
According to the schedule, the film will show across several venues in Lagos and Abuja on Thursday, June 25 and Sunday, June 28.
Dazzling Mirage, fresh from winning the Audience Choice Awards at the NollywoodWeek Festival, Paris, stars Taiwo Ajai-Lycett, Yomi Fash-Lanso, Kunle Afolayan, Kemi Lala Akindoju, Seun Akindele and more.
The movie is a screen adaptation of Yinka Egbokhare's novel with the same name.


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So, I just finished my first Ripped workout. First things first, my arms hurt a lot right now. Also, my husband just made fun of me because to check that, I lifted them up and he sang "I believe I can fly" at me but I digress. The reason I'm surprised by this is because the toning sticks included with the programme are only 1lb, so around 500grams. I really focused on making them heavier so kind of resisting the moves with my muscles to make the weights seem heavier and get a better workout.
My thighs and bum are both killing me as well, like I can complain about that, after all I'd love to have a nice bum and skinny thighs and this is the best way to get it! Also, abs...so much ab work! A lot of obliques which is what will get me the six pack I've always wanted but haven't had since I was 10 years old and doing gymnastics!
I've just been online to the Zumba shop and ordered some of the 2.5lb (or a bit over 1kg) toning sticks along with some Zumba shoes. The sneakers that I'm wearing, I've had forever and for doing a lot of the Zumba moves, they dig in to my ankles. I was pleased to find that Zumba had a shop in Australia because I was thinking I'd have to order from the US (which I was prepared to do) and would have to wait weeks for shipping so that was a total plus!
Hmmmmm, what else...the workout was good but there were still a lot of dance moves in it. For some reason me and the salsa do not mix! My feet just get tangled up in each other so I gave up and just did "step out, step together, step out, step together". I know eventually I'll get the hang of it and I don't think I've mentioned this yet but I spend a lot of the workout giggling at myself (which I've heard helps you lose weight!!!).
Anyway, I'm off to have dinner, grab a shower and...I dunno. Collapse, probably! Fingers crossed my legs will hold me up long enough to actually shower!


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Mayo Clinic Connect
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Both my wife and I have received the finest of diagnosis, care, and treatment at Mayo Rochester. We couldn't be more pleased with Mayo.
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Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer
Xiang R.,Scripps Research Institute |
Xiang R.,Nankai University |
Liao D.,Scripps Research Institute |
Cheng T.,Scripps Research Institute |
And 6 more authors.
British Journal of Cancer | Year: 2011
Background:The cancer stem cell hypothesis suggests that neoplastic clones are maintained exclusively by a small subpopulation of cells, which have indefinite proliferation and differentiation potentials and give rise to phenotypically diverse cancer cells. Cancer stem cells have been isolated by their ability to efflux Hoechst 33342 dye and are referred to as the side population (SP).Methods and results:The Hoechst efflux assay was used to isolate and characterize the SP from murine D121 lung carcinoma cells. Here, we demonstrated that D121-SP cells contain cancer stem cell characteristics, that is, upregulation of the transcription factors SOX2 and Oct 4 in D121-SP cells. In addition, the migration of D121-SP was decreased, and apoptosis of D121-SP was upregulated following knocking down of SOX2 in D121 cells. Importantly, downregulation of SOX2 in D121 cells markedly suppressed their metastatic potential in syngeneic mice.Conclusions:These results suggest that the SP is an enriched source of lung tumour cells with stem cell properties and that SOX2 has an important role in maintaining stem cell properties and functions that may be a potential target for effective lung cancer therapy. © 2011 Cancer Research UK All rights reserved. Source
Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53
Bai N.,Nankai University |
Zhang C.,Nankai University |
Liang N.,Nankai University |
Zhang Z.,Nankai University |
And 14 more authors.
Cancer Biology and Therapy | Year: 2013
The yes-associated protein (Yap) transcription co-activator has been reported either as an oncogene candidate or a tumor suppressor. Liver tissue chips revealed that about 51.4% human hepatocellular carcinoma (hCC) samples express Yap and 32.9% hCC samples express phosphorylated Yap. In this study, we found that chemotherapy increased Yap protein expression and nuclear translocation in hepG2 cells, as well as p53 protein expression and nuclear translocation. however, little is known about Yap functions during chemotherapy. Our results show that overexpression of Yap increases chemosensitivity of hepG2 cells during chemotherapy. Dominant negative transfection of Flag-s94a (TeaD binding domain mutant) or Flag-W1W2 (WW domain mutant) to hepG2 cells decreases p53 expression/nuclear translocation and chemosensitivity when compared with control hepG2 cells. Furthermore, rescue transfection of Flag-5sa-s94a or Flag-5sa-W1W2, respectively to hepG2 cells regains p53 expression/nuclear translocation and chemosensitivity. These results indicate that Yap promotes chemosensitivity by modulating p53 during chemotherapy and both TeaD and WW binding domains are required for Yap-mediated p53 function. ChIp assay results also indicated that Yap binds directly to the p53 promoter to improve its expression. In addition, p53 could positively feedback Yap expression through binding to the Yap promoter. Taken together, our current data indicate that Yap functions as a tumor suppressor that enhances apoptosis by modulating p53 during chemotherapy. © 2013 Landes Bioscience. Source
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine egfr/stat3/sox-2 signaling pathway
Yang J.,Nankai University |
Liao D.,Scripps Research Institute |
Chen C.,Beijing Union Medical School |
Liu Y.,National Health Research Institute |
And 5 more authors.
Stem Cells | Year: 2013
The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of tumorigenesis. Additionally, tumor-associated macrophages (TAMs) are known to promote growth and metastasis of breast cancer. However, it is not known whether TAMs mediate tumorigenesis through regulation of breast CSCs. Here, we report that TAMs promote CSC-like phenotypes in murine breast cancer cells by upregulating their expression of Sox-2. These CSC-like phenotypes were characterized by increased Sox-2, Oct-4, Nanog, AbcG2, and Sca-1 gene expression, in addition to increased drug-efflux capacity, resistance to chemotherapy, and increased tumorigenicity in vivo. Downregulation of Sox-2 in tumor cells by siRNA blocked the ability of TAMs to induce these CSC-like phenotypes and inhibited tumor growth in vivo. Furthermore, we identified a novel epidermal growth factor receptor (EGFR)/signal transducers and activators of transcription 3 (Stat3)/Sox-2 paracrine signaling pathway between macrophages and mouse breast cancer cells that is required for macrophage-induced upregulation of Sox-2 and CSC phenotypes in tumor cells. We showed that this crosstalk was effectively blocked by the small molecule inhibitors AG1478 or CDDO-Im against EGFR and Stat3, respectively. Therefore, our report identifies a novel role for TAMs in breast CSC regulation and establishes a rationale for targeting the EGFR/Stat3/Sox-2 signaling pathway for CSC therapy. © 2012 AlphaMed Press. Source
Effect of NF-κB decoy on insulin resistance of adipocytes from patients with type 2 diabetes mellitus
Zhong L.,Chongqing Medical University |
Luo Y.,Beijing Union Medical School |
Huang C.,Chengdu Railway Central Hospital |
Liu L.,Chongqing Medical University
Diabetes and Metabolism | Year: 2011
Aim: This study aimed to investigate whether NF-κB contributes to insulin resistance in type 2 diabetes (T2DM). Methods: Subcutaneous abdominal adipose tissue was obtained from T2DM patients and non-diabetic control subjects. Pre-adipocytes were cultured and differentiated into adipocytes in vitro. Upon insulin stimulation, IRS-1 tyrosine and AKT (Ser473) phosphorylation were examined by immunoprecipitation and immunoblotting, while levels of inflammatory mediators IL-6 and MCP-1, and the DNA-binding activity of NF-κB, were examined by ELISA and electrophoretic mobility shift assay (EMSA), respectively. NF-κB decoy molecules were introduced into T2DM adipocytes, and their effects on all these molecular events evaluated. Results: Compared with cells from non-diabetic subjects, adipocytes from T2DM patients showed signs of insulin resistance, with significantly reduced IRS-1 tyrosine and AKT (Ser 473) phosphorylation levels in response to insulin stimulation. At the same time, T2DM cells displayed elevated levels of IL-6 and MCP-1, and NF-κB activity. Introduction of NF-κB decoy molecules significantly inhibited both IL-6 secretion and NF-κB activity, while enhancing insulin-stimulated IRS-1 tyrosine and AKT (Ser473) phosphorylation in T2DM adipocytes. Conclusion: Abdominal subcutaneous fat cells from T2DM patients display signs of insulin resistance and microinflammatory status. NF-κB decoy molecules inhibited NF-κB overactivation and also partly reversed insulin resistance. These results provide evidence of a link between inflammation and insulin resistance in T2DM cells, suggesting a potential contribution of inflammation to the mechanism of insulin resistance. © 2011 Elsevier Masson SAS. Source
Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation
Shen L.,Nankai University |
Qin K.,Nankai University |
Wang D.,Nankai University |
Zhang Y.,Nankai University |
And 5 more authors.
Biochimica et Biophysica Acta - Molecular Basis of Disease | Year: 2014
Although Oct4 is known as a critical transcription factor involved in maintaining "stemness", its role in tumor metastasis is still controversial. Herein, we overexpressed and silenced Oct4 expression in two breast cancer cell lines, MDA-MB-231 and 4T1, separately. Our data showed that ectopic overexpression of Oct4 suppressed cell migration and invasion in vitro and the formation of metastatic lung nodules in vivo. Conversely, Oct4 downregulation increased the metastatic potential of breast cancer cells both in vitro and in vivo. Furthermore, we identified Rnd1 as the downstream target of Oct4 by ribonucleic acid sequencing (RNA-seq) analysis, which was significantly downregulated upon Oct4 overexpression. Chromatin immunoprecipitation assays revealed the binding of Oct4 to the promoter region of Rnd1 by ectopic overexpression of Oct4. Dual luciferase assays indicated that Oct4 overexpression suppressed transcriptional activity of the Rnd1 promoter. Moreover, overexpression of Rnd1 partially rescued the inhibitory effects of Oct4 on the migration and invasion of breast cancer cells. Overexpression of Rnd1 counteracted the influence of Oct4 on the formation of cell adhesion and lamellipodia, which implied a potential underlying mechanism involving Rnd1. In addition, we also found that overexpression of Oct4 led to an elevation of E-cadherin expression, even in 4T1 cells that possess a relatively high basal level of E-cadherin. Rnd1 overexpression impaired the promoting effects of Oct4 on E-cadherin expression in MDA-MB-231 cells. These results suggest that Oct4 affects the metastatic potential of breast cancer cells through Rnd1-mediated effects that influence cell motility and E-cadherin expression. © 2014 Elsevier B.V. Source


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Detect bilirubin in urine
Prevent adulteration prior to specimen collection
For the semi-quantitative determination of Ketones (acetoacetic acid & acetone) in urine, serum, plasma and whole blood. Replaces the discountinued Bayer Acetest. Same test procedure at the Acetest™. Detects as little as 5mg/dl of acetoacetic acid in urine.
Contain several ingredients for semi-quantitative measurement of ketones in urine
Quantitative method for measuring reducing substances in urine


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Blog Posts in Category: calcium deficiency
April 4, 2014
Campaigns pushing milk rich in calcium as the answer to strong bones are notorious. But does the saying "got milk?" really translate into "got strong bones?" There is in fact an important message behind the infamous milk mustache. Calcium is a mineral that is not only important for the body's nervous and cardiovascular systems, but is vital to our bone health. Approximately ninety nine percent of the body's calcium reserve is stored in our bones and teeth to support their structure and function... Read More
Recent Posts
Join UNH's Student Nutrition Association Here at UNH, a lot of people are looking for more ways to... Read more
Tips to Manage your Emotional Wellbeing Throughout the Semester As the semester begins, it's easy... Read more
Are Fats Actually Good For You, or Should They be Avoided? With nutrition advice changing on a... Read more


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Louis La Roche – Kaboom EP
Louis La Roche
Out now on OM Records is a absolutely banging House/Nu Disco EP, "Kaboom" from UK producer Louis La Roche!Born as Brett Ewels, he has been producing electronic music since 2008 and has released 5 EPs since. His work has been featured on Ministry of Sound releases, as well as gaining airplay on Radio1. He is planning on releasing his debut album "Hello You" soon, which is sure to gain him even more play time and popularity!
On this EP, La Roche starts with Kaboom, a smooth house track featuring a groovy, melodic synth and some light vocal sampling. He then moved to more of an indie dance/nu-disco feel with FunkTrunkSkunk, where he samples "Lalabye" by D.R.U.M and pairs it with an easily dance-able, upbeat rhythm.
Louis La Roche – Kaboom
Louis La Roche – FunkTrunkSkunk
You can buy the EP here on Beatport!
Connect with Louis La Roche:
Facebook // Twitter // Soundcloud
Conner Thomas
Latest posts by Conner Thomas (see all)
- Check out Erik Smalls' free bootleg of Deadmau5 and Armin van Buuren! - May 1, 2015
- Richie Hawtin's CNTRL Tour is a gift from the techno gods - April 30, 2015
- The Seattle Trance Scene is Making a Comeback in 2015 - February 19, 2015
- DJ Hodor is Bringing the Rave of Thrones to Seattle - November 26, 2014
- UMEK and Mike Vale Turn up the Funk - November 24, 2014


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The Storm: The World Economic Crisis and What it Means
Guide price: £7
Last updated on 20th May 2009
The Storm: The World Economic Crisis and What it Means
The Storm: The World Economic Crisis and What it Means
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1493: Uncovering the New World Columbus Created
A deeply engaging new history of how European settlements in the post-Colombian Americas shaped the world, from the bestselling author of 1491. Presenting the latest research by biologists, anthropologists, archaeologists, and historians, Mann shows how the post-Columbian network of ecological and economic exchange fostered the rise of Europe, devastated imperial China, convulsed Africa, and for two centuries made Mexico City—where Asia, Europe, and the new frontier of the Americas dynamically interacted—the center of the world. In this history, Mann uncovers the germ of today's fiercest political disputes, from immigration to trade policy to culture wars. In 1493, Mann has again given readers an eye-opening scientific interpretation of our past, unequaled in its authority and fascination.
Crisis On The Danube: Napoleon's Austrian Campaign
Crisis On The Danube: Napoleon's Austrian Campaign Of 1809
Botanica Magnifica: Portraits Of The World's Most
Botanica Magnifica features two hundred and fifty stunning photographs by HasselbladLaureate Award winner Jonathan Singer, representingGÇöin the words of an ARTnewscriticGÇörare or exotic plants and flowers GÇ£in large scale and exquisite detail, emergingfrom the shadows in a manner evocative of Old Master paintings.GÇ¥
Holidays Around The World: Celebrate Independence
Holidays Around The World: Celebrate Independence Day: With Parades, Picnics, And Fireworks Strike up the band, pack a picnic, and enjoy the fireworks. Celebrate Independence Day takes a nationwide perspective on the joy of America's biggest party. All the history and culture of Independence Day is here, along with fun facts, an all-American recipe, a locator map for every photo and a complete resource guide. Deborah Heiligman's rich narrative evokes the patriotic flavor of the Fourth—and explains its associations with liberty and democracy. The text also looks at how people from other nations celebrate their independence days, and includes an expert consultant's note.


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AfghanistanChinaCentral AsiaIndia-PakistanIndonesiaKoreaMyanmarNepalPhilippinesMicronesiaSri LankaThailand
Potential HotspotsTerrorismTop Ten Conflicts
Russians about the Iranian arms sales.
Iran arrested to Turkish PKK rebels who had crossed over the border from northern Iraq to obtain medical care. One of the two turned out to be a senior PKK commander and Turkey has asked that he be extradited to Turkey for trial. Some 4,000 PKK rebels, who are Kurds, have taken refuge in northern Iraq, also populated by Kurds. Across the border in Iran, there are more Kurds. In the 1970s, the Kurds in all three nations were in rebellion, seeking to form a Kurdish state. This effort failed, and Iran keeps a sharp watch on its Kurds. In the last few years, Iran and Turkey have cooperated in dealing with Kurdish rebels. This, despite support
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"Fast Money Halftime Report" traders Jon and Pete Najarian discusses unusual options activity in Gold ETF (GLD) and Nu Skin Enterprises.
Shares of cosmetics manufacturer Nu Skin Enterprises fell Friday after reporting disappointing sales and current quarter guidance.
Shares of Nu Skin plunge on weak Q1 guidance. CNBC's Seema Mody reports.


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Hotels in Acquarica
Hotel reservation
Hotel rooms in Acquarica
There are not so many hotel rooms in Acquarica, just 15, still everyone can find an offer to suit his choice. The most common offers in this city are guest houses, they count 8 out of 15, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the north of Acquarica, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Acquarica. The most populated with hotels district of Acquarica is the center, 86% of cheap hotel rooms are concentrated here. However, even those who want to live in the north can choose from 1 variants of hotel rooms. Acquarica is a truly multifaceted city, here everyone can find a hotel of his choice: a business person, a young couple or a family with little children. Apart from all these, hotels in Acquarica offer their customers pets allowed and swimming pool. Take a look at our selection of the cheap hotel rooms in Acquarica to make a well-informed choice for your reservation!
Acquarica cheap hotels
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All cheap hotels in Acquarica
hotel collections
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"We are responsible for those who tamed" - said Antoine de Saint-Exupery.
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Best hotels in Acquarica
Hotels in Acquarica are spread around the city within the distance of 1.7 kilometers, while 13 hotels are located directly in the city center. The most popular accommodations in Acquarica is
located in a 0.5 kilometers from the city center.
The best hotels are here and now. Try them!
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The GDNF Emax® ImmunoAssay Systems provide optimized reagents and a protocol for the sensitive and specific detection of glial cell-line-derived neurotrophic factor (GDNF). After an overnight coating of a 96-well plate, the specific protein is detected using an antibody sandwich format. The systems use horseradish peroxidase-conjugated secondary antibody and a single-component TMB substrate for the final chromogenic detection of bound neurotrophic factor. Using this system, GDNF in tissue culture supernatants or tissue homogenates can be quantitated in the range of 15.6–1,000pg/ml.
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GDNF Emax® ImmunoAssay System
Anti-Human GDNF pAb
Block & Sample 5X Buffer
Anti-Human GDNF mAb
GDNF Standard
TMB One Solution
Anti-Chicken IgY, HRP
This product can be added to a
This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.
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Store the entire system in its original package protected from light at –20°C. Once thawed, store the system (except the GDNF Standard) at 4°C.
For product intended use please see Patents & Disclaimers tab.
G7620, G7621 For Research Use Only. Not for Use in Diagnostic Procedures.
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Ratings based on 2,273 Verified Reviews
4.3 Room cleanliness
4.1 Service & staff
4.1 Room comfort
4.1 Hotel condition
Expedia Verified Reviews
for Everyoneby A verified traveler from SC
Excellent experiencePosted Feb 24, 2017
All of the staff that I encounter were very polite, friendly and helpful. The rooms were clean overall it is now my favorite Hotel
for Everyoneby A verified traveler from Toronto
Great location for a family vacation.Posted Feb 22, 2017
Hotel was ok, could use a refresh on some cosmetics but itherwise was good.
for Everyoneby A verified traveler
Posted Feb 17, 2017
My only complaint was the constant noise from street construction right under our balcony. It was horrible
for Everyoneby A verified traveler
Posted Feb 17, 2017
I had a wonderful time! Room was clean, front desk staff was very polite and helpful. I definitely plan to use choose this hotel again!!!
for Couplesby A verified traveler from Columbia, SC
Great location!Posted Feb 6, 2017
Pros: Location, cleanliness, service, and the view.
Location: We highly recommend 8th Ave. Tiki Bar for their hummus and Dirty Don's and Moe Moons on the Boardwalk.
My wife and I decided on Wednesday to take a trip to the beach. We love staying on the Boardwalk since we can walk to area restaurants. Our hotel was very nice. We were on the 8th floor, ocean front and we had a great stay. The staff was very friendly and accommodating. The room was spotless and definitely met our needs. Also, having a Starbucks attached to the property was a plus! Everything was perfect for a great weekend getaway.
for Everyoneby A verified traveler from South Carolina
Nice beach access!!Posted Jan 22, 2017
I had a great time!! Will definitely go back! ASAP....
for Everyoneby A verified traveler from J
Posted Jan 16, 2017
Got to the resort staff was very friendly, quick check in clean rooms, going back very soon.
for Everyoneby A verified traveler from Maryland
Very close to the beach!Posted Jan 15, 2017
Clean and nice oceanfront view! The welcoming staffs are very accomodating!
for Everyoneby A verified traveler from Va
Posted Jan 9, 2017
Cons: The pool room and water could be warmer in the winter... The outside sliding doors in the pool room had inch wide gaps in them letting cold air in.
Note that the parking garage is a block away from hotel.
for Everyoneby A verified traveler
Oceanfront roomPosted Dec 28, 2016
Oceanfront room was very well priced would definitely stay again but room was very cramped with two beds overrall was nice resort


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Top Definition
A feminine girl who is attracted to both genders. Similar to the idea of a lip stick lesbian.
Lady Gaga could be an example for a blush bi sexual.
by Katakeel November 29, 2010
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


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Boys Basketball Elite Development Camp
Sunday, June 16, 2013 3 PM
Cost: See brochure for cost
Category: Kids & Families, Community Event
Contact: Thelma Abbott 701.777.3478
Contact Dept: Athletics
Website: www.undsports.com//ViewArticle.dbml?DB_OEM_ID=13500&ATCLID=204781192
Betty Engelstad Sioux Center
801 Oxford St.
Grand Forks, ND 58202
This overnight basketball camp is designed to provide position-specific instruction, including post player development sessions and perimeter player development sessions. Combined position instruction, including post entry and relocation, screen and roll techniques, high-low offense and defensive strategies for post and perimeter players. More than 80 of the best players from North Dakota, South Dakota, Minnesota, Iowa, Wisconsin and Canada attended the camp last summer. (Grades 8 - 12)
Parking InformationUnless special parking arrangements have been stated above, off-campus guests for this event may use the pay-as-you-go option in the Parking Ramp (corner of 2nd Ave N and Columbia Road), the Visitor Lot (off Centennial Drive), or a Parking Meter. Parking in any other parking lot on-campus requires a parking pass which can be purchased directly through UND Parking and Transportation Services, 3925 Campus Rd Stop 9030 (8:00 a.m. – 4:30 p.m. Monday – Friday).
Other Events on This Day
- "Finding North Dakota" 250 Years of Mapping Exhibit (All Day)
- Coffee with the Naturalist (9:30 AM)
- Football 7-on7 Passing Camp/OL-DL Challenge (12:30 PM)
- Teen Anime Club (3 PM)
- Girl's Basketball Elite Camp (3 PM)
- INMED Summer Institute Program (3 PM)
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GT-OD Overdrive
- Traditional, transparent, and warm overdrive
- Adds sustain and gain without coloring your guitar or amp's tone
GT-OD Overdrive Info
Built from the ground up with the best available components, the MXR GT-OD Overdrive pedal creates smooth, warm, and classic overdrive without excess noise or tone coloring. The simple controls make it easy to dial in a great tone quickly—from crunchy rhythm tone with chord clarity—to sparkly and harmonicrich lead tones with tons of sustain. You won't find an overdrive that is more organic, responsive or open sounding.
Power: Dunlop ECB003 AC Adapter or Single 9 volt battery
GT-OD Overdrive Videos
Page 123
GT-OD Overdrive Sounds
"Blues for Stevie" Strat/ Blackface
"Dan's Boogie" Strat/ Blackface
"Texas Blue" Strat/ Blackface
This is product is not currently available at the Dunlop Online Store, perhaps one of our dealers is carrying it.
Visit our dealer search
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Elsevier Releases New Nursing and Allied Health Journal Abstracts and Indexing Database
Mosby's Nursing Index provides nurses access to the latest nursing literature to aid in research and patient care
April 12, 2007 – St. Louis, Missouri USA – Elsevier, a world-leading nursing and medical publisher, today announced the release of Mosby's Nursing Index, its new nursing and allied health journal abstracts and indexing database for the nurse and allied health professional.
Mosby's Nursing Index was created by Elsevier, publisher of Mosby and Saunders publications, and includes cover-to-cover indexing of more than 2,500 international source titles, including peer-reviewed journals, trade publications and electronic-only titles. It also includes over 200 unique titles that are not included in other commercial nursing databases. The coverage includes evidence-based healthcare; nursing specialties and professions; nursing education and training; nursing development and management.
"Nurses need access to the latest literature to base their practice on solid clinical evidence," says Louis Pilla, Product Director, Mosby's Nursing Index, Elsevier. "Mosby's Nursing Index provides a powerful resource for accessing this current practice information."
Mosby's Nursing Index is available now to healthcare providers as a subscription-based service as part of their Mosby's Nursing Consult subscription or as a stand-alone service to serve the nursing organization.
"The demands placed on today's nurse are greater than ever and we are dedicated to supporting the nurse with the latest nursing literature to provide better patient care," says Brian K. Bussey, President, Mosby MCS, a division of Elsevier Health Sciences. "This supports our goal in assisting the nurse and other allied health professionals to make better informed decisions to improve patient care."
More information can be found at www.MosbysNursingIndex.com or at booth 109 at the Medical Library Association (MLA) annual conference in Philadelphia, Pennsylvania, USA, May 19 – 22, 2007.
About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey— and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. www.elsevier.com
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Nikon Coolpix L19 camera
Nikon's Life range of easy to use compacts has seen a revamp in recent months and the L19 sits mid-way within the range below the (yep, you guessed it) L20 and oddly, the range topping L100 but above the, wait for it … L18!
The camera's plastic bodywork may not inspire but the styling allows the camera to sit neatly in the hand. The top plate sports a large shutter release and smaller on/off button, camera shooting mode and playback buttons just behind.
The spartan back plate provides a disappointingly small and fiddly zoom control while a ubiquitous four-way jog control encircles a central OK button and is joined by a delete and menu button.
That's your lot in terms of controls which helps ensure Nikon's easy to use "Life" series ethos is maintained. The menu button provides access to the meat of the camera settings (as you'd expect) but this makes it necessarily slow when switching settings such as white balance and the colour options. You can adjust resolution/quality and the shooting mode and that's about it.
The latter options provides single, continuous and multi-shot modes that can shoot a quick-fire sequence of 16-images combined, collage fashion into a single shot, so handy to get shots of fast moving subjects as a sequence of smaller thumbs.
However, the continuous setting provides shooting at around one frame per second and you get BSS or best shot selector, which shoots a sequence of ten images and the camera "picks" the sharpest image and dumps the rest.
The motion detection works well enough but because it bumps up the sensitivity from the camera's automatically adjusted 64 to 1600 ISO range, noise problems can be an issue as the sensitivity creeps up, particularly when it goes above ISO 800.
However at the lower ISOs, noise is well controlled and without detail leeching too, which is a refreshing change. Other clever kit includes the Smart portrait system that combines smile detection with a blink warning along with the way the camera processes the portrait shots helping you get the most from your people pictures.
The Easy Auto mode is designed to let you turn on the camera and shoot without worrying about settings since the camera "chooses" settings based on the scene before the lens. You get 16-scene modes to choose between as well, so you can tailor the camera to specific shooting situations such as party, night portrait, and landscape and macro modes.
The 5cm macro mode reasonable for this level of camera as is the nice lens, which provides a fairly limited wide angle end of 41mm but a respectable 145mm full zoom ratio. The lens is however sharp and fairly distortion free. However the focus system is a little hit and miss, particularly in Macro mode where it seems to get confused by more cluttered scenes and it's not the fastest of AF systems either acerbated by slight shutter lag, typical of a camera at this level.
White balance (WB) control is great in all but the auto mode, a disappointment given the likely purchaser of this camera is not going to be tinkering much with WB settings, but at least you do have manual control of WB, unlike the ISO settings.
WB under fluorescent lighting, images are disappointingly orange hued while in mixed lighting … ditto. Set a particular white balance to the WB performance dramatically improves.
Images are saved onto SD/SDHC cards though MMC cards are not supported. Powered by dual AA cells, you'll be able to get the camera powered up anywhere as AA's are widely available and my concerns that the supplied alkaline batteries would do no mare than a few were unfounded.
After over 100-shots and plenty of reviewing, they're still growing strong, so Nikon has managed to control the power usage really well. To that end the large screen is nice to have and has a great anti-reflection coating but the lack of an optical viewfinder means you cannot save power by switching the screen off.
Interestingly, the camera's flash is ideal for little more than a fill-in, but flash exposures are very good indeed and the one nod to more advanced usage is the inclusion of exposure compensation to brighten or darken scenes the (fixed) metering finds harder to handle though I must say, it usually provides an excellent balance.
Overall then the L19 provides a simple to use camera with enough automated kit to satisfy most users, Nikon's D-Lighting is also included so you can adjust images (in playback mode) to balance shadow and highlights but without loosing detail in either. It works well enough.
Apart from a small zoom control, the Nikon Coolpix L19 has a great control layout that's easy to fathom thus making handling very simple indeed. In fact, the L19 provides exactly what you would need or expect from a point and shooter that's combined with some excellent automated Nikon features and good low ISO image quality.
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Digital Preservation DAVID GIARETTA (APA) FIRST PRELIDA WORKSHOP, TIRRENIA, JUNE 25TH-- ‐ 27TH,2013
Outline Fundamental demands Fundamental concepts Trust OAIS and Linked Data
Fundamental demands
Preservation and value Why pays? Why? What to preserve? What value?
Examples Books Web Science data What are the differences?
Value RIDING THE WAVE
Vision 2030 (2) Researchers and practitioners from any discipline are able to find, access and process the data they need. They can be confident in their ability to use and understand data and they can evaluate the degree to which the data can be trusted. Create a robust, reliable, flexible, green, evolvable data framework with appropriate governance and long-term funding schemes to key services such as Persistent Identification and registries of metadata. Propose a directive demanding that data descriptions and provenance are associated with public (and other) data. Create a directive to set up a unified authentication and authorisation system. Set Grand Challenges to aggregate domains. Provide "forums" to define strategies at disciplinary and cross-disciplinary levels for metadata definition. IMPACT IF ACHIEVED Dramatic progress in the efficiency of the scientific process, and rapid advances in our understanding of our complex world, enabling the best brains to thrive wherever they are.
Vision 2030 (3) Producers of data benefit from opening it to broad access and prefer to deposit their data with confidence in reliable repositories. A framework of repositories work to international standards, to ensure they are trustworthy. Propose reliable metrics to assess the quality and impact of datasets. All agencies should recognise high quality data publication in career advancement. Create instruments so long-term (rolling) EU and national funding is available for the maintenance and curation of significant datasets. Help create and support international audit and certification processes. Link funding of repositories at EU and national level to their evaluation. Create the discipline of data scientist, to ensure curation and quality in all aspects of the system. IMPACT IF ACHIEVED Data-rich society with information that can be used for new and unexpected purposes. Trustworthy information is useable now and for future generations.
Vision 2030 (4) Public funding rises, because funding bodies have confidence that their investments in research are paying back extra dividends to society, through increased use and re-use of publicly generated data. EU and national agencies mandate that data management plans be created. IMPACT IF ACHIEVED Funders have a strategic view of the value of data produced.
Vision 2030 (6) The public has access and can make creative use of the huge amount of data available; it can also contribute to the data store and enrich it. All can be adequately educated and prepared to benefit from this abundance of information. Create non-specialist as well as specialist data access, visualisation, mining and research environments. Create annotation services to collect views and derived results. Create data recommender systems. Embed data science in all training and academic qualifications. Integrate into gaming and social networks IMPACT IF ACHIEVED Citizens get a better awareness of and confidence in sciences, and can play an active role in evidence based decision making and can question statements made in the media.
Vision 2030 (7) Policy makers can make decisions based on solid evidence, and can monitor the impacts of these decisions. Government becomes more trustworthy. Policy makers are able to make decisions based on solid evidence, and can monitor the impacts of these decisions. Government becomes more trustworthy. IMPACT IF ACHIEVED Policy decisions are evidence-based to bridge the gap between society and decision-making, and increase public confidence in political decisions.
Fundamental concepts OAIS
Digital Preservation… Easy to do… …as long as you can provide money forever Easy to test claims about repositories… …as long as you live a long time
Preservation techniques For each technique look for evidence – what evidence? must at least make sure we consider different types of data ◦rendered vs non-rendered ◦composite vs simple ◦dynamic vs static ◦active vs passive must look at all types of threats
Threats Things change…… ◦Hardware ◦Software ◦Environment ◦Tacit knowledge Things become unfamiliar
Problems when preserving data Preserve? Preserve what? For how long? How to test? Which people? Which organisations? How well? Metadata? – What kind? How much?
"A fundamental characteristic of our age is the raising tide of data – global, diverse, valuable and complex. In the realm of science, this is both an opportunity and a challenge." Report of the High-Level Group on Scientific Data, October 2010 "Riding the Wave: how Europe can gain from the raising tide of scientific data" raising tide of data… Requirements Who pays? Why?
Raising tide of data…
Data contains numbers etc – need meaning 20
... to be combined and processed to get this 21 Level 2Level 0Level 1 Processing Processing/ combining
Preserving digitally encoded information Ensure that digitally encoded information are understandable and usable over the long term ◦Long term could start at just a few years ◦Chain of preservation Need to do something because things become "unfamiliar" over time But the same techniques enable use of data which is "unfamiliar" right now
Preservation Planning Data Management Data Management Archival Storage Archival Storage Access Ingest SIP Descriptive Information AIP queries query responses orders DIP MANAGEMENT Administration Lots of useful terminology
Key OAIS Concepts Claiming "This is being preserved" is untestable ◦Essentially meaningless ◦Except "BIT PRESERVATION" How can we make it testable? ◦Claim to be able to continue to "do something" with it ◦Understand/use ◦Need Representation Information Still meaningless… ◦Things are too interrelated ◦Representation Information potentially unlimited ◦Need to define a Designated Community – those we guarantee can understand – so we can test
OAIS Information model: Representation Information The Information Model is key Recursion ends at KNOWLEDGEBASE of the DESIGNATED COMMUNITY (this knowledge will change over time and region) Does not demand that ALL Representation Information be collected at once. A process which can be tested
Dictionary specification XML GOCE N1 file description Representation Network GOCE Level 1 (N1 File Format) GOCE Level 0 Processor Algorithm GOCE N1 file Dictionary GOCE N1 file standard PDF standard PDF software
Archival Information Package Preservation Description Information Preservation Description Information Content Information further described by Package Description Packaging Information derived from described by delimited by identifies Data Object Data Object Representation Information Representation Information Physical Object Digital Object Structure Information Semantic Information Reference Information Provenance Information Context Information Fixity Information Other Representation Information Interpreted using Bit adds meaning to Access Rights Information Interpreted using 1 * 1 1...*
Representation Information Representation Information Provenance has
When things changes We need to: ◦Know something has changed ◦Identify the implications of that change ◦Decide on the best course of action for preservation ◦What RepInfo we need to fill the gaps ◦Created by someone else or creating a new one ◦If transformed: how to maintain data authenticity ◦Alternatively: hand it over to another repository ◦Make sure data continues to be usable
Transformation Change the format e.g. ◦Word PDF/A ◦PDF/A does not support macros ◦GIF JPEG2000 ◦Resolution/ colour depth……. ◦Excel table FITS file ◦NB FITS does not support formulae ◦Old EO or proprietary format HDF ◦Certainly need to change STRUCTURE RepInfo ◦May need to change SEMANTIC RepInfo Transformational Information Properties
Hand-over Preservation requires funding Funding for a dataset (or a repository) may stop Need to be ready to hand over everything needed for preservation ◦OAIS (ISO 14721) defines "Archival Information Package (AIP). ◦Issues: ◦Storage naming conventions ◦Representation Information ◦Provenance ◦Identifiers ◦….
ThreatRequirement for solution Users may be unable to understand or use the data e.g. the semantics, format, processes or algorithms involved Ability to create and maintain adequate Representation Information Non-maintainability of essential hardware, software or support environment may make the information inaccessible Ability to share information about the availability of hardware and software and their replacements/substitutes The chain of evidence may be lost and there may be lack of certainty of provenance or authenticity Ability to bring together evidence from diverse sources about the Authenticity of a digital object Access and use restrictions may make it difficult to reuse data, or alternatively may not be respected in future Ability to deal with Digital Rights correctly in a changing and evolving environment Loss of ability to identify the location of data An ID resolver which is really persistent The current custodian of the data, whether an organisation or project, may cease to exist at some point in the future Brokering of organisations to hold data and the ability to package together the information needed to transfer information between organisations ready for long term preservation The ones we trust to look after the digital holdings may let us down Certification process so that one can have confidence about whom to trust to preserve data holdings over the long term RepInfo toolkit, Packager and Registry – to create and store Representation Information. In addition the Orchestration Manager and Knowledge Gap Manager help to ensure that the RepInfo is adequate. Registry and Orchestration Manager to exchange information about the obsolescence of hardware and software, amongst other changes. The Representation Information will include such things as software source code and emulators. Authenticity toolkit will allow one to capture evidence from many sources which may be used to judge Authenticity. Packaging toolkit to package access rights policy into AIP Persistent Identifier system: such a system will allow objects to be located over time. Orchestration Manager will, amongst other things, allow the exchange of information about datasets which need to be passed from one curator to another. Certification toolkit to help repository manager capture evidence for ISO 16363 Audit and Certification
Infrastructure support SCIDIP-ES ◦Converting CASPAR prototypes into robust services
Vision 2030 (2) Researchers and practitioners from any discipline are able to find, access and process the data they need. They can be confident in their ability to use and understand data and they can evaluate the degree to which the data can be trusted. Create a robust, reliable, flexible, green, evolvable data framework with appropriate governance and long-term funding schemes to key services such as Persistent Identification and registries of metadata. Propose a directive demanding that data descriptions and provenance are associated with public (and other) data. Create a directive to set up a unified authentication and authorisation system. Set Grand Challenges to aggregate domains. Provide "forums" to define strategies at disciplinary and cross-disciplinary levels for metadata definition. IMPACT IF ACHIEVED Dramatic progress in the efficiency of the scientific process, and rapid advances in our understanding of our complex world, enabling the best brains to thrive wherever they are.
Trust IssueVision 2030ShortMediumLong authenticity of data Scientists can establish the authenticity of the data they use ● Standardised system for provenance and related evidence in repositories. ● Standardised way to capture reputation of data producers and holders ● Adoption of machine readable provenance in major repositories ● Capture of reputation of producers and holders (see Social networking) ● 80% of repositories of scientific data have adequate machine readable evidence ● Automated ways to evaluate evidence of authenticity validity of data Users and systems will be able to evaluate the reputation of the data they use. Annotation system for datasets, with efforts to formalise annotation language Ranking system to allow systems to produce rankings of levels of trust (akin to Page rank but based on reputation rather than links) Systems can choose datasets which are most trustworthy and can evaluate the risks involved in using less trusted data. certification of repositories People can make a judgement about which repositories can be trusted International system of repository certification created Certification demanded by EU and national funders 80% of major repositories of scientific data are certified global trust issues Users can deal with the global datasets with the same confidence as European sources Discussions with US, China, etc MOU with international agencies on common standards International agreement so that users have evidence of authenticity for world-wide scientific data Complexity of the system People can trust that the ever more complex tangle of systems are doing the right thing Simplify interfaces and entanglement. Move towards autonomic, self- configuring, self-healing, self- optimising and self-protecting systems, with appropriate monitoring. Systems have survived many generations of changes in technologies and architectures.
Reality check What could jeopardise the vision Counter by: Lack of long term investment in critical components such as persistent identification Identify new funding mechanisms Identify new sources of funding Identify risks and benefits associated with digitally encoded information Lack of preparation Ensure the required research is done in advance Lack of willingness to co- operate across disciplines/ funders/ nations Apply subsidiarity principle so we do not step on researchers' toes Take advantage of growing need of integration: within and across disciplines Lack of published data Provide ways for data producers to benefit from publishing their data Lack of trust Need ways of managing reputations Need ways of auditing and certifying repositories Need quality, impact, and trust metrics for datasets Not enough data experts Need to train data scientists and to make researchers aware of the importance of sharing their data The infrastructure is not used Work closely with real users and build according to their requirements Make data use interesting – for example integrating into games Use "data recommender" systems i.e. "you may also be interested in..." Too complex to work Do not aim for a single top down system Ensure effective governance and maintenance system (c.f. IETF) Lack of coherent data description allowing re-use of data Provide "forums" to define strategies at disciplinary and cross-disciplinary levels for metadata definition From Riding the Wave
Trust issues Has it been preserved properly? Is it of high quality? Has it been changed in some way? Does the pointer get me to the right object?
Has it been preserved properly? Can the repository be trusted? Certification of various kinds ISO16363 certification should be available soon Judged on the basis of evidence collected and examined
Is it of good quality? More than one in ten scientists and doctors claim to have witnessed colleagues deliberately fabricating data in order to get their research published, a new poll has revealed. The survey of almost 2,800 experts in Britain also found six per cent knew of possible research misconduct at their own institution that has not been properly investigated. The poll for the hugely-respected British Medical Journal (BMJ) http://www.dailymail.co.uk/sciencetech/article- 2085814/Scientists-falsify-data-research-published- whistleblowers-bullied-keeping-quiet-claim-colleagues.html
Dirk Smeesters had spent several years of his career as a social psychologist at Erasmus University in Rotterdam studying how consumers behaved in different situations. Did colour have an effect on what they bought? How did death-related stories in the media affect how people picked products? And was it better to use supermodels in cosmetics adverts than average-looking women? The questions are certainly intriguing, but unfortunately for anyone wanting truthful answers, some of Smeesters' work turned out to be fraudulent. The psychologist, who admitted "massaging" the data in some of his papers, resigned from his position in June after being investigated by his university, which had been tipped off by Uri Simonsohn from the University of Pennsylvania in Philadelphia. Simonsohn carried out an independent analysis of the data and was suspicious of how perfect many of Smeesters' results seemed when, statistically speaking, there should have been more variation in his measurements. Dutch psychologist Diederik Stapel. He was found to have fabricated data for years and published it in at least 30 peer-reviewed papers, including a report in the journal Science about how untidy environments may encourage discrimination. http://www.guardian.co.uk/science/2012/sep/13/scientific-research-fraud- bad-practice
Peer review of data ….is difficult
Lessons from APARSEN Data Quality Cost Models for preservation Preservation tools Preservation services
Has it been changed in some way? OAIS defines Authenticity as: The degree to which a person (or system) regards an object as what it is purported to be. Authenticity is judged on the basis of evidence. Need to capture evidence –what evidence?
Authenticity evidence Authenticity Model Provenance capture ◦How to deal with combinations of data ◦How to deal with changes Security and tampering with logs
OAIS and Linked Data
Linked Open Data: Issues Links – just another dataset? Or do we have to view as part of a huge "cloud" is that cloud just another dataset? Is it just like archiving snapshots of the Web? Snapshots? But at different times across the cloud HTTP URIs – how persistent? HTTP – how persistent? RDF – how persistent? What do the links mean?
OAIS-related issues Designated community Representation Information Provenance Rights Authenticity Trustability Is it easier to "poison" the system?
OAIS / Linked Data questions Can OAIS concepts be applied to the preservation of Linked Data? Do existing concepts apply? Are new concepts needed? What new terminology is needed?
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Hi Peter,
Anthurium eminens reminds me of Schefflera. I don't know if there's a climber
in the latter genus, but you'll know when it blooms!!
Lynn Hannon
<<< Hi everybody,
I received a climbing Anthurium plant with a leaf form very typical of a
Is there such a plant or is there a climbing Schefflera?
If anybody could enlighten me on this it would be great.
Many Thanks


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Sub-50 fs broadband absorption spectroscopy with tunable excitation: putting the analysis of ultrafast molecular dynamics on solid ground
- First Online:
- Received:
DOI: 10.1007/s00340-009-3610-0
- Cite this article as:
- Megerle, U., Pugliesi, I., Schriever, C. et al. Appl. Phys. B (2009) 96: 215. doi:10.1007/s00340-009-3610-0
- Citations
- 1.8k Downloads
We give a full description of a state-of-the-art femtosecond transient spectrometer. The setup has been put together under full consideration of all technical and conceptual developments that became available in the last few years. Particular care was taken to avoid any unneeded components and modules.
The spectrometer is operated at 1 kHz and based on a commercial Ti:sapphire amplifier. A noncollinear parametric amplifier and frequency doubling are used to provide pump tuning from the UV to the NIR. A CaF2 based single filament white light allows for 290 to 720 nm probing. The multichannel detection is operated at the full 1 kHz rate and chopping of the pump light avoids the use of a reference channel. The resulting high detection sensitivity of better than ΔOD=10−4 allows for the simultaneous recording of the spectral features of electronic states and species with differing transition strengths.
A prism-based polychromator is employed to avoid the order sorting problem with the more than octave wide probe spectrum and to enhance the throughput. Flow cells with 200 μm windows and down to 120 μm sample thickness reduce the coherent artifact and the group velocity mismatch. This results in an overall sub-50 fs temporal resolution.


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FLIR's new GFx320 represents ground breaking technology for visualizing fugitive leaks at natural gas well sites, off-shore platforms, liquid natural gas terminals, and more. Its Intrinsically Safe designation means surveyors can work confidently inside critical safety zones.
Read more
Today at the 2017 Consumer Electronics Show (CES) in Las Vegas, Nevada, FLIR announced their latest camera for personal and commercial drone use, the FLIR Duo.
Happy Halloween from all of us at FLIR! We thought we'd catch up with our friend Jason Hawes, producer and host SyFy's reality series Ghost Hunters and founder of The Atlantic Paranormal Society. Check out how he uses FLIR thermal cameras in his paranormal research!
Every month, we recognize a heroic act by the customers who use FLIR's technology. This month we highlight a story close to FLIR's corporate headquarter featuring Clackamas Fire District #1 in Oregon. This is the courageous story of how FLIR's K45 Thermal Imaging Camera (TIC) aided in the search and rescue of a victim from a fully enflamed house in September.
Two FLIR optical gas imaging (OGI) cameras – the FLIR GF320 and GF300 – have received sensitivity standard validation by UK-based National Physical Laboratory (NPL), making them compliant with the US Environmental Protection Agency (EPA's) recently announced methane rule.
Today at the ASIS Security show, FLIR announced the new version of Latitude VMS. Now, Latitude integrates with FLIR's industry-leading thermal security cameras and recorders and provides support for large sites of up to ten thousand security cameras in a single directory.
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KXFA84 Drum Unit, Black
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text: Seller: mandiayala87 (72) 100%, Location: Lakeland, Florida, Ships to: US, Item: 162277518300 This is a pair of vintage andirons in great condition. They sort of resemble owls with a arrow shaped lower feather.They are cast iron and the finish looks to be original. Here are the dimensions: 14" high10" wide7" deep Color: Black, Maker: unknown, Material: Cast Iron


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Although Teflon-coated frying pans have a non-stick surface, they sometimes require seasoning. "Seasoning" means to treat the pan with oil to create, or rejuvenate, a non-stick surface. Cast iron pans traditionally require regular seasoning. But, with use and as Teflon-coated pans age, the surface may need to be seasoned to add to its life and effectiveness. Seasoning a Teflon-coated frying pan, or other Teflon-coated cookware, is fast and simple.
- Skill level:
- Easy
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Things you need
- Vegetable oil
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- 1
Heat the Teflon-coated frying pan on the hob until it is just warm.
- 2
Add just enough vegetable oil to to coat the inside of the pan.
- 3
Swirl the oil in the pan to evenly coat the surface.
- 4
Heat the oil until ripples begin to appear on the oil's surface.
- 5
Remove the pan from the burner and pour out the oil.
- 6
Wipe the inside of the pan with paper towels to remove the excess oil.
- 7
Let the pan cool to room temperature.
Tips and warnings
- Seasoned Teflon pans should be washed with warm soapy water and dried immediately.
- Do not put seasoned Teflon pans in the dishwasher.
- Do not use abrasive cleaners or sponges on seasoned Teflon pans.
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