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Welcome to Peabody Music Box in Peabody, Massachusetts, where we have been teaching children and adults to play music throughout the North Shore since 1975. We teach a wide range of music lessons and also offer musical instrument repair and sales. Whether you want to learn the keyboard, trumpet, or mandolin, we provide all the sales, repair, and lessons you need.
Learn More about Peabody Music Box


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Contour an area of your body with a non-invasive procedure that is designed to eliminate fat cells and reduce the appearance of cellulite
SOQI Total Detox Therapy - One ($19) or Two Sessions ($37) at Chi Health Spa, Albion (Up to $120 Value)
Treatment designed to detox the body by expanding blood vessels, assisting with rapid toxin release and absorption of essential nutrients
View Deal
Up to Eight Fat Cavitation Sessions on One Area (From $65) at Curve's Contouring & Beauty Clinic (Up to $800 Value)
Aims to reduce fat, cellulite and tighten skin in a non-surgical, effective and pain-free way to get rid of unwanted body fat
Slim Bodies 3-Week Weight Loss Program: Pick up ($39) or Delivery ($49) (Up to $178.99 Value)
Pursue your health goals with a 3-week weight loss program featuring calorie controlled diet plan, and homeopathic slim bodies spray
Laser Lipo Treatments - Two ($89), Six ($239) or Eight ($319) at Hollywood Blow Outs and Medi Spa (Up to $1,134 Value)
Target stubborn fat cells in areas of the body to tighten the skin and reduce the appearance of cellulite during a non-invasive procedure
Cellulite Reduction - Three ($79), Five ($129) or Ten Treatments ($235) at Chi Health Spa, CBD (Up to $1,200 Value)
Treatment employs radio waves in an effort to target wobbly areas like thighs, abdomen or buttocks; designed to be quick and non-invasive
Ultrasonic Fat Cavitation - One ($49) or Three Sessions ($99) at Electrolysis and Laser Clinic (Up to $330 Value)
Focus on the jaw line, stomach, upper arms, or thighs with a non-surgical and non-invasive fat cavitation treatment
Mesowave Treatment - One ($135) or Two Visits ($199) at Beauty Blitz, Logan Central (Up to $598 Value)
Mesowave uses currents to help reactivate nerves and muscles for firmer, fresher skin that appears youthful and healthy

subset: commoncrawl


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Greetings Guest!!Dismiss Notice
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Call To Arms Moonglow Under Attack! Time is now: 8:30pm ET
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About Design
We believe that Design comes from the minds of the Newell Brand's employees as well as its customers and consumers. To that end, we actively stimulate collaboration, visualize opportunity and help propose product and package graphic concepts that are offered up via both formal and informal methodologies throughout the company. The Design team are the innovation agents who continually drive the development of better ideas and the processes which enable growth for Newell Brands. If you are interested in a Design job at Newell Brands, check out our available opportunities.
30 Design Jobs Found
Automation EngineerMogadore, Ohio Posting Date: 02/17/2017
Mgr, Graphic DesignKalamazoo, Michigan Posting Date: 02/16/2017
Quality Engineer of ExcellenceAtlanta, Georgia Posting Date: 02/16/2017
Quality EngineerChicago, Illinois Posting Date: 02/16/2017
Sr Graphic DesignerKalamazoo, Michigan Posting Date: 02/16/2017
Operations EngineerMogadore, Ohio Posting Date: 02/14/2017
Principal User Experience ResearcherKalamazoo, Michigan Posting Date: 02/09/2017
Associate Fashion DesignerTokyo, Tokyo Posting Date: 02/08/2017
Supplier Quality EngineerWinchester, Virginia Posting Date: 02/07/2017
Senior Industrial DesignerKalamazoo, Michigan Posting Date: 02/06/2017
Paint & Coating EngineerWinchester, Virginia Posting Date: 02/01/2017
Associate Quality EngineerAtlanta, Georgia Posting Date: 02/01/2017
Quality EngineerAtlanta, Georgia Posting Date: 01/31/2017
Quality EngineerAtlanta, Georgia Posting Date: 01/31/2017
Quality EngineerVictorville, California Posting Date: 01/31/2017
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Use the hashtag #LifeAtNWL to explore the Newell Brands Story: Our Growth. Our Brands. Our People.
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For hundreds of millions of consumers, Newell Brands makes life better every day, where they live, learn, work and play. Our employees work together to do the same thing.
If you are an applicant with a disability who is unable to use our online tools to apply for positions, send an email to firstname.lastname@example.com. Please indicate the Job ID and the specifics of the assistance needed. This option is reserved for individuals with disabilities who need an alternative method of applying for open positions


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Hotfrog Philippines provides information regarding Fortress Food Products in Antipolo Rizal. Fortress Food Products is located at 74-A. Sumulong Hi-way, Antipolo Rizal and provides food and beverage services. Contact them on (02) 682 8272.
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With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
Tell us about yourself!
i were hoping that I could find the answer to how to build a h bridge to change a electric door locking system from "fail-safe" to "fail -secure".can someone help me please
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text: Neuroscience in Marketing: The (Brain)wave of the Future Neuroscience in marketing has come a long way, and the Raka team picked up some key insights at INBOUND 16 that are worth sharing. Read More How to Beat Writer's Block: Tips for Content Marketers (and Everyone Else) Tip #1: Take this list of tips for beating writer's block and find what works best for you as a writer and content marketer. Read More Writing For People, Not Search Engines Writing for online audiences is tricky, but the thing to remember is that you're not writing for search engines. You're writing for people. Read More Four Ways to Keep Your Email List Healthy (And Why That Matters) If your email list isn't clean and healthy, neither are your email marketing efforts. Here's some tips for effectively managing your contacts to avoid that unpleasant reality. Read More Three Common Twitter Mistakes Your Brand Should Avoid Every company makes mistakes on Twitter, but there are three incredibly common brand errors you need to avoid, and we'll tell you how. Read More What Is Google Plus In 2016, And Who's Using It? If you've found yourself asking "What is Google Plus," we've got you covered. Here are three ways it's still relevant for businesses in 2016 (and beyond). Read More How to Combine Concepts and Keywords In Your 2017 SEO Strategy When you're planning your SEO strategy for 2017 and beyond, consider this: Concepts are the future, keywords are the past. Read More Insights From an Inbound Marketing Intern: Acronyms and Ice Cream Sandwiches As a Raka intern and inbound marketing newbie, I'm here to give you my insights into what it's like to be learning digital marketing from the ground up. Read More How to Make LinkedIn Marketing Work For You—Yes, You LinkedIn marketing isn't necessarily simple, but there are a few avenues on the platform that you can use to connect with the audiences you care about most. Read More Inbound Marketing Blog Phrases We Should Stop Using, According to Inbound.org Raka recently asked Inbound.org users which overused phrases they dread seeing in blog posts. The answers were funny, and a reminder to all of us. Read More Prev 1 2 3 4 5 6 7 8 9 … 26 Next


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Popular Now
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By: J Beal
218 pages, 218p.; Reprint ed. Trade Paper
ProQuest Information and Learning
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Prefab House Prefabricated Excellent Quality And Reasonable Price - Chinaprice: contact company for price
Prefab house is a light steel skeleton, sandwich panels for the building envelope material, a combination of a series of standard modulus space, connected components using bolts, a new concept of green economy activities housing. Can be quickly and easily assembled and disassembled, temporary buildings common standardized set of environmental protection and energy saving, efficient building concepts, temporary housing into a serial development and integrated production, supporting the supply, inventory and can the multiple turnover stereotypes product areas.
Product Detail:
Material:Sandwich Panel
Wall:50mm EPS sandwich panel
Flat roof:blue, insulation, corrugated sandwich panel
Use:House, Office, Sentry Box, Guard House, Shop, Toilet, Villa
Sandwich panel door with aluminum alloy frame
Door: EPS sandwich panel door with aluminum alloy frame
Aluminum window:aluminum window with one glass
Frame:steel frame with paint
The color board house quality and performance:
1 color plate activity room earthquake seven, of Wind Resistance nine;
2 light steel combination Housing seismic eight, the wind resistance twelve;
3 second-floor design, supports dynamic load 150kg / sq.m.;
4 activities of the board more than 15 years of service life.
Company Contact:
- Posted By: Shenzhen Jinya Steel Structure Co.,Ltd.
- Phone: 15013439209
- Address: Bao'an avenue beside,Fuyong street,Bao'an District, Shenzhen, China
- Email:
- Website: http://shop1366810345080.cn.1688.com
Published date: June 18, 2013 -
- Business Description: The company is engaged in the development, production and construction
of light steel structure housing, has many years of experience in the
industry, with superb technology, rich experience, quality service,
reasonable prices, consistent, win the trust of domestic and foreign
friends. The products direct Singapore, Russia, India, Vietnam, Saudi
Arabia, Malaysia, Africa, North America, Europe, Australia, Middle East,
Southeast Asia etc.
In the country provide nearly 150,000 square meters of board room material, Sichuan disaster areas in the country, State Road 107 three transformation engineering, the eastern coastal high speed project, the south light high speed project, Nanping rapid Engineering Excellence Century Center Mall, the construction of China South City Shenzhen Municipal Engineering, world University Games in Shenzhen Stadium project construction Group, in the then Group, China Railway Group and other buildings project design, install a combination of a large number of multi style activities room. The first class quality and perfect service, our customers get the praise.
"Standard, general purpose, aesthetic, economic, security, environmental protection," for the purpose, with a comprehensive modern enterprise management system and high tech team, to advocate advanced business management thinking, to enhance the level of corporate management and product technical upgrade tireless efforts.
Related listings
Modern Living Container Homes Prefab House Movable DormitoryPre-Fabricated Buildings - Shenzhen Jinya Steel Structure Co.,Ltd. - China - June 18, 2013 - contact company for price
Material: 1.Structure: light steel or steel as main frame/structure 2.Insulation material: sandwich panel ( EPS, PU, rock wool) 3.all and roofs: sandwich panel, corrugated sandwich panel, asphalt tile 4.Windows and doors: UPVC or aluminum window, san...
Container House Movable Dormitory Home Prefab Site OfficePre-Fabricated Buildings - Shenzhen Jinya Steel Structure Co.,Ltd. - China - June 18, 2013 - contact company for price
Specifications 1.EPS sandwich panel 2.good insulation 3.easy construction 4.could be office or dormitory 5.flexible design Product features: 1. Use container as base construction material overthrows the traditional mode of construction and creates a ...
Container Homes House Prefab Quick Build Disaster ReliefPre-Fabricated Buildings - Shenzhen Jinya Steel Structure Co.,Ltd. - China - June 18, 2013 - contact company for price
introduction: We are specialized in producing container house, container homes is our developing container product which using"set"as the unit , can be combined freely .It is convenient to move, installation fast , low cost, Our container homes equip...
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A sturdy aluminum rack panel pre-loaded with XLR chassis connectors on the front and solder connectors on the rear. Ideal for use in stage box systems, patch-bays or studios.
12 Male XLR
12 Female XLR
24 Male XLR
24 Female XLR
MCM is a great company. Very fast service and shipping of Raspberry Pi. Will tell all my friends to buy from MCM


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Hotel Bahosi
Find Hotel Rates
Recent Searches
Wego searches multiple travel sites so you can find and compare the best rates.
Hotel Bahosi Hotel Reviews
Based on reviews from across the web.
Hotel Bahosi Hotel Details
- Boutiques/stores
- Elevators
- Internet services
- Poolside snack bar
- Room service
- Safe deposit box
Hotel Bahosi is a popular choice amongst travelers in Yangon, whether exploring or just passing through. The hotel offers guests a range of services and amenities designed to provide comfort and convenience. 24-hour front desk, car park, room service, free Wi-Fi in all rooms, shared lounge/TV area are on the list of things guests can enjoy. Guestrooms are fitted with all the amenities you need for a good night's sleep. In some of the rooms, guests can find television, complimentary bottled water, in room safe, television LCD/plasma screen, internet access – wireless. The hotel offers various recreational opportunities. Hotel Bahosi combines warm hospitality with a lovely ambiance to make your stay in Yangon unforgettable.


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Livestream of #noNATO protests in Chicago
Watch the #noNATO protests live on http://www.livestream.com/chicagoindymedia Watch live streaming video from chicagoindymedia at livestream.com
Watch the #noNATO protests live on http://www.livestream.com/chicagoindymedia Watch live streaming video from chicagoindymedia at livestream.com
As zombies threaten to consume all that's left of our spectacular society, B Media's "Occupation Nation" slams the new era of global uprising into an hour-long episode of remixed shorts that explore the philosophical roots of the recent movement of 99%. The mycelia network that has spread across the world is deeply rooted in historical precedents that have the potential to turn toxic assets and discarded derivatives into new communities where shared vision and collective decision making empowers us all. […]
People in over 80 cities across the US participated in creative and direct actions against corporations that benefit from their relation to the American Legislative Exchange Council (ALEC), a shadowy "non-profit" that buddies up state legislators with the biggest business interests in the world. In Portland over a thousand people braved the freezing sideways rain to participate in a well organized (and unpermitted) march with affinity groups staging multiple actions along the route.
The world is now smarter about ALEC. Thousands of people in 80+ in the US and many more abroad gathered to shed light on the shadowy American Legislative Exchange Council and their destructive involvement in communities around the world. #F29 marks the most coordinated global occupy action to date.
The shadowy American Legislative Exchange Council has been forced into the limelight today as thousands of people from Portland to Mexico City, to New York and Spain take part in protests against this destructive and un-democratic body. Watch Portland's live stream here: Watch live streaming video from occupyptown at livestream.com
Portland's Fast Rattler brings you the bangin' new cult classic Occupy anthem "Take It To The Streets". Words were written in part by Utah Phillips and sung by Bodhi Busick.
Outrage : Eviction at Occupy Wall Street from Phil Airey on Vimeo. An excellent piece by Phil Airey on the events that transpired last week with the brutal eviction of Occupy Wall Street from Zucotti Park. Video demonstrating the suspension of the First Amendment of the Constitution of the United States of America in New York City and the institutionalised corruption of the NYPD through the narrative of the eviction of the Occupy Wall Street camp at Liberty Square on […]


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iPhone apps
GalaXseeds - Tuber Shooter Lite
This is the free lite version of GalaXseeds Tuber Shooter,a fast paced arcade game in which you must defend your plant from invading insects enemies.The game can be played both with the accelerometer and the touch screen.Tuber Shooter is closely….. Read more
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Fling Cube - Block Shooter LITE
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SteelSeries Sensei Fnatic Edition
The Sensei is the grand-master in the SteelSeries dojo. It is the teacher. The one everyone bows to, the one who knows tricks and secret moves that everyone wants to learn--but so very few can ever hope to master. Featuring a state-of-the-art laser sensor that offers consistent and reliable performance, the SteelSeries Sensei boasts 10.8-megapixel HD image correlation at up to 12,000 frames per second and the ability to handle tracking movements of up to 150 inches per second.
The Sensei was co-designed by one of the world's most accomplished gaming teams, Fnatic. Fnatic is a professional electronic sports team consisting of players from across the globe who all make a living through competing in video game tournaments. The Fnatic team won the ESports Team Of The Year Award in 2006 and 2009. Fnatic is currently supporting a list of highly successful squads in StarCraft 2, League of Legends, Call of Duty, and Counter-Strike to name a few.
32 Bit ARM Processor
The processor in SteelSeries Sensei is a 32 bit ARM processor and it is as fast as the original Pentium 75 MHz processor released by Intel in 1994. This reference may sound like overkill, but it's this type of power that allows it to do sophisticated calculations directly on the mouse, without the need for software drivers and without having to rely on the user's computer.
SteelSeries' industry-leading ExactTech settings, like ExactSens, ExactRate, ExactAim and more, are calculated directly on the mouse providing the user with a mouse movement that is completely free of any interpolation or extrapolation, without any delay or filtering, and without using up memory or resources on the user's computer.
On-Mouse LCD Menu
With the LCD display on the backside of the SteelSeries Sensei, you can customize all settings to fit your specific needs. The LCD menu offers setup of even the most advanced ExactTech settings.
It also allows you to upload your own bitmap picture, offering a great way to personalize your mouse--and help prevent theft at LAN-events, gaming cafes and other public places. Design your own unique picture for the Sensei LCD display, download it to your computer and upload to your Sensei via the SteelSeries Engine software.
Advanced Macros
Thanks to the support of the SteelSeries Engine software, you can record even extremely long and advanced macros to the Sensei. The macros can be layered and can include keystrokes and precise timing. How you will decide to use this advanced feature is up to you--choose your configurations wisely and adhere to any rules that you may need to abide by during gameplay.
ExactLift: Adjustable Lift Distance
The Sensei gives you the ability to customize the lift distance. This has a number of practical applications, most importantly it allows you to fine-tune the mouse to your preferred mousepad or mousing surface. Not all surfaces are equal. Surfaces are made of many different types of materials and those different materials have different qualities. They can be reflective, rough, smooth...the list goes on. All of these factors will influence the lift distance of a normal mouse; with the Sensei, we put a whole new dimension of control in your hands.
ExactAim: Slow Down And Focus
Headshots anyone? SteelSeries ExactAim will allow you to be more precise. As you slow down your cursor the mouse will decelerate even more allowing you to focus on your target.
ExactAccel: Move Faster
SteelSeries ExactAccel does just the opposite of ExactAim. As you increase the speed of your mouse movement, ExactAccel will accelerate your movements even faster in order for you to move across your game or page faster.
ExactSens: Control The Sensitivity
SteelSeries ExactSens allows you to control how fast your pointer should move by adjusting your CPI in increments of 1 between 1 to 5,700 CPI. This means, the SteelSeries Sensei offers you true hardware based sensitivity settings, freeing you of interpolation from game software. To really get the full benefit from ExactSens you need to deactivate any cursor acceleration and set your sensitivity settings in-game (sensitivity 1 or adjust your sensitivity slider to lowest possible setting) and on your operating system to default.
Plug, Play, Win
There's no need to install software of any kind in order to use the Sensei. The built-in driver can be adjusted through an LCD menu on the backside of the mouse. Simply plug in the Sensei and play. For the PC gamers who want really advanced customization options, the Sensei is supported by SteelSeries Engine technology.
- Programmable macro buttons
- Ambidextrous shape
- Driverless plug-and-play
- User defined bitmaps for the XXXXXonMouse LCD
- SteelSeries ExactSens, FreeMove, ExactAim, and ExactLift
- Menu system on the mouse
- Gold-plated USB connector
- Three zone lighting - Scroll Wheel, CPI Indicator, and Logo
Credit Cards (Mastercard & Visa)
We currently accept Mastercard and Visa credit cards. Your credit card information is secured and safeguarded when shopping at Youbeli.com. All information are encrypted and sent through secured and protected channels. As we are employing Mobile88 (iPay88) as our payment gateway, Mobile88 will be stated in your credit card statement.
Financial Process Exchange (FPX)
We also accepts FPX payment method as it is an ideal payment solution for customers who does not have a credit card. All that is needed to make an online payment is an online banking account. Payment is directly linked and connected to the customer's specified online banking account, transactions are usually instant and fast. Supported banks includes:
Cash Bank-in / Online Fund Transfer / Cheque
You may bank-in cash or cheque into the selected bank account below:
Bank : PUBLIC BANK
Account Name : YOUBUY ONLINE SDN BHD
Account No. : 3194858935
Bank : MAYBANK
Account Name : YOUBUY ONLINE SDN BHD
Account No. : 514048612629
Once you have successfully bank-in the amount, email the bank in slip to firstname.lastname@example.com with the stated Order No.
PayPal lets you send payments quickly and securely online using a credit card or bank account.
Not valid for cash only items.
|Delivery Fee (RM)
|West Malaysia
|First 1.00 kg
|West Malaysia
|Additional 1.00 kg
|East Malaysia
|First 1.00 kg
|East Malaysia
|Additional 1.00 kg
Courier Services
CITY-LINK Express Website: http://www.citylinkexpress.com
|SKYNET Express Website: http://www.skynet.com.my
SKYNET Express Hotline: 03- 7958 2800
All purchases which including Games, PC Games Collector Edition, Gaming Accessories* / Action Figures / Computer Hardware / IT Gadget will charge based on weight.


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These Beach Baseball poems are examples of Beach poems about Baseball. These are the best examples of Beach Baseball poems written by international PoetrySoup poets
If you don't find the poem you want here, try our incredible, super duper, all-knowing, advanced poem search engine.
While you sleep I tell you all of the things I keep inside throughout day.
Now that you can hear but not listen I find them much easier to say.
My hopes, my dreams, my fears, and everything in between
Your subconscious hears so keen, or so it seems.
My tongue is soft; I speak so sweetly
Knowing your reaction will never greet me.
Tonight will be different in what I want you to know.
It has everything to do with what I can't help but show.
I hold no claim to any religion but you've given me a place for my faith.
Somewhere it will never stale or lose its lavish taste.
You've shown me something I can see, touch, and feel,
And so before it I choose to kneel.
I know I don't say it but I miss you every day.
Sitting, thinking of the perfect words to be my choice,
Yet when you call I can't find any of the right words to say.
I'm just happy to finally hear your voice.
Even just a moment is enough to sooth my heavy heart;
Fearing the ends of conversations knowing we'll have to part.
I'll never be too far from you, always within arm's reach,
And in your days of darkness I'll be the light that you will seek.
I'll never let you leave too far from me, I'll stay close behind you in this world;
Secretly protecting what is mine, you will always be my girl.
I only want the best for you so the best of me I will employ.
Faithfully yours, I will always be your boy.
I close my eyes and kiss your soft sweet lips
And see the very best of you in loving bliss.
I see past the physical which makes you attractive
And focus on the things I can't see in which I'm attracted.
Your thoughts I'd love to hear them all.
Of the things you speak disinterest never makes its call.
My day will come, I know someday I'll be the only one.
And you I will pursue viciously,
Because I've given you the greatest gift I can give, to love unconditionally.
Yes our day will come, I know someday we'll be as one.
And you I will pursue viciously,
Because I've given you the greatest gift I can give… to love unconditionally.
Copyright © Kristopher Higgs | Year Posted 2012
My knees were the things that
kept me up and my skin is my
cutting board my eyes are the
rain clouds to the fire running
down my arms and my heart is
the fire place that keeps me
burning so calm
Copyright © brittney lopez | Year Posted 2013
Romantic, close
A subject of sweetest softness
Cats can be loved too
Copyright © Smail Poems | Year Posted 2013
Never Give Up
Hang on; The Lord will give you strength in any act of your pursuit
Keep trusting God; He will lead you in every step of the journey
Don't live by other people's time tables; live by Gods Time Table.
You may lose paradise, but gain heaven when you rise up and repent
Don't underestimate your ability to pick yourself up and keep going.
Let go of your disappointments, mistakes and failures
Never give up on your missions and visions.
Never give up praying, The Lord will answer you in His beautiful timing.
The Lord will prepare you for the great success which will comes unexpectedly.
Your dreams are planted deep within your heart by Life itself.
Don't be discouraged by people who tease you out of your dreams
Overcome any struggle with courage, motivation and hope
Your dreams were given to you for a reason by THE CREATOR.
It is easy to give up in life than to keep trying. Always choose the latter
Try again; you have millions of alternatives
Get rid of that negative and defeated attitude.
Always stayed focused on your goals and hang on the wings of hope and success
Be consistent in your efforts, success is not obtained overnight
Push through every difficulty and negativity to achieve the goals
To achieve the impossible, you must attempt the absurd
Never settle for less than what you imagined possible for yourself.
Be determined to be determined
The victory over our inner self is a daily struggle
Resist every negative criticism and persist to make it happen
Go forward and conquer any mountain on your path
Quitters and waiters have a varied beginning, but a similar ending
Just underneath your breaking point lies your true strength
Don't stop where you fall; rise up and do it again!"
Your downfall is a preparation for your up-rise
Without adversity and trials we may never know what we are capable of.
Mistakes help to sharpen your next steps.
Focus on the precious moments and gracious future.
Never give up, pursue your passion
Successful people never quit –upgrade your mindset and keep focus
Stay strong, stay positive, and never give up.
Only the weak use "I can't" as an excuse to give up
Copyright © Seth Yuhi Musinga | Year Posted 2015
'Baby, you taste like chocolate,
You and me we'd make a great rhyming couplet.
A.K.A a grinding couplet.'
'You can get on top of me like enjambment.'
'I can show you some wild imagery,
Me on you, you on me.'
'Metaphor stands for meet-at-four,
We'll get it on till the break of dawn.'
'Damn, could you BE anymore sexual?' -an example of a rhetorical question you could include...
'S-s-s-s-s-SEX!'- an example of sibilance you could use (and probably will).
'Annotate me honey, and together we can achieve a deeper meaning.'
Copyright © Poetry Aircraft Carrier B | Year Posted 2013
Who am I?
Am I defined by what is near in sight?
Am I defined by what I have done,
Or am I defined by what I could become?
Perhaps I'm of no use.
To him, or her, or I, nor you.
Or perhaps I'm too misunderstood to be defined,
And it is something like understanding that comes in time.
And if to the world I'm never shown,
Yet in my own light I've grown and grown,
And so I can know no happiness but my own--
The reason for my smile, to you, will forever be unknown.
I do not pray for the world to know my name.
For it and verse; the letters are the same.
And if a man should find his sorrow in what he reads,
I pray his pain my words to keep.
Should his eyes rain on my page,
Better tears than storms of rage.
And if a man should find his sorrow in what he reads.
I pray his pain my words to keep.
And if to the world you're never shown,
Yet in your own light you've grown and grown,
And so you know no happiness but your own.
Let the reason for your smile, to you, only be known.
Copyright © Kristopher Higgs | Year Posted 2013
these brick bound boxes
fill this equinox of smart headed people
of these independent achievable people
critical analysts of this 21 century
ready to be presentable to the unmighty
smaller population of antisocial teenage children
willing them to be
not to be free, but inside these brick bound boxes
that fill the human intelligence with total
literate irrelevance to who we should be
to who can be
ultimately like them
filled in these brick bound boxes
with mental instimulance
of a mix of lies, creation and motives
see, I don't have a problem with any of them
just these brick bound boxes that hold them
hold this unforgettable willing mind
of someone we chose to leave behind
in these brick bound boxes
that encompass first the mind and then the soul
but who wants all this control?
society can speak of a whole.
an incredible strong mental image
of how life is to be--
within these brick bound boxes.
My life isn't based in these brick bound boxes
but it soon will
creating a song of the monotone dead
longing to be passed on from generation to generation
but can't you see
can't you forget that this is not who we ought to be
unless we need to spontaneously combust
in this equinox till it metastasizes
catastro sizes to an everlasting dust
even you must ought to smell the musk.
So tell me, how do thee?
how do thee live with these brick bound boxes
filling up every empty not-yet-set concrete whole
implying of who you are before you could even
have some kind of control over yourself
its swept under the rug.
no biggie, you're just a kiddie
no actual value to this reality
yet before you can buy alcohol
and I'm someone to sound big
I just don't want to fill these lonely brick bound boxes
where the death of every living will cease to be a beginning
in this equinox of the everlasting dust,
so do you must, live in these brick bound boxes?
Copyright © Lottie Cats | Year Posted 2014
very bad &
Copyright © ur mom | Year Posted 2016
now its cold
its the soup bold
something hot
a boiling pot
soon will be the bright nights
with summer light at midnight
mabe a cool wind
Copyright © kurtis scott aka curtis futch jr | Year Posted 2016
The secretion of a Lilly is often mistaken for the timbers of a concrete ball. Many a time is the goldfish singing for a curry. Golden gophers gluing glitter. A wolf dancing in a stew of peas is more happy than a porcupine on a rocket powered skateboard.ooooh grammar of framing a drugged frog is as indigestible as spinning around the earth twice after consuming large amounts of beer. Like a tidal wave then. Humming. Humorous isn't it. Turbulent tambourines turning tripe. Intoxication z.
Copyright © Taoi Chanan | Year Posted 2016
My ears perked up at Bauer
When the radio talked sports.
A player for the Indians,
By all the news reports,
Was set to pitch Game 2
(The Series winding towards the end)
When he had a "pinkie laceration,"
Needing time to mend.
He'll get to start Game 3, they hope,
His hobby left alone,
For Trevor Bauer's injury
Was blamed upon his drone.
When baseball Bauers hit the news,
(I've 2 of them to thank)
I won't claim kinship to the drone guy,
Just to Cousin Hank!*
(not true!)
Copyright © ilene bauer | Year Posted 2016
Taxes are not talking nor are they taxis. But airports are often very congested. Packed tightly forming queues. Vastly unreported by news. News are neatly arranged newts in a bath licking ice cream. And a single melt of globular sploosh is merely an unwelcome loss. So washing becomes very dextrous in beckoning an eroded surface. Bubbles can form at will from depths of over fifty five feet. Whereupon a steely coloured beast of old will rise to take on even the mightiest of modern weaponry. When travelling in herds step left right left rigidly and always steer to the centre. Cinematic viewpoints of pathways filled with the patterned stardust trails. Break no saucepan in a rage. And cage no plant. It is to be said that at this time the potency of a banana sandwich with jam can run at great athletic speed over a basin drop. So always drag a meal to a ballroom. With chains. It is also wise and often imperative to shield eyes with cups and harness the knives,forks,and spoons. So as to avoid the high fluted champagne glasses who can be very nasty if crossed. Particularly if wearing a nine million pound gown. Sweep no lawn for lawns must be mown with a one centimetre pair of scissors. Many blades. Long time cutting. And dangling off the central high way at midnight is a feat only achieved by a very large circular bat. Pinnacles painting prisons playing political polo parties. And jester moments from the east and west ignite laughter and cheers from birth and south. So far heard by the eleventh moon many miles away. Air current velocity then. In a bowl. Chatting to a ladle about the state the potatoes are arranged in. It us simply not done. Unheard of in fact. To chop and place potatoes next to carrot and cabbage when all must surely know by now that this is unsafe as they simply do not get along together and therefore the soup will taste most sour. Dour diaries digging digital downloaded dreams. And a large portion of porridge in a mist on the horizon. Skipping. Hahahaha face of a thoughtful tissue. Hahaha exclamations exciting existential exotic experiences explicitly. Hahaha rotunda rotating rut. Xxxxx numerology Z that was the latest from the p y q reporting from a morning zoo next to a nice sty. Z cvb jackets Z.
Oh great. It is time to build a snowman in a fire place. Just ensure even placement and it is imperative to use the fire guard. Shrink sinking surrounding shaping shifting sailing sip. A shapeless garment on a large frame is jumping over road works now. Wow. A flying flurry of conquering onion and garlic pie with the scent of one star anise. And a bay leaf. Air no charging herd of bank notes to a horizontal horizon for horizontal happens here having horses, hounds and hippopotamus heals in a radius of two point eight circular twilight buds. Now move. Form a queue of nouns and get served by an asterisk shaped female. Whose antics in the pie aisle is packed with generically green grand groups and one smiling pea has now returned from a world cruise. Hahaha tinkling travelling trademarks trampling trampolining tyrannosauruses'. Hahaha collection of forks linking hands with the spoons then go sledging on a six wheeled bike. Ghanaian going out for dinner. Xxxxx multidisciplinary z that was the p Y Q reporting from a swirl of zones on a fifty acre cake. Z. Unilingual z and a diagram of a dish clapping. Z
A rabbit and a currant had a race once up a very vertical hill. Upon arrival it was said to be the place of much dignified worship in many a tunnel. But thus was neither planned nor placed. Ironing out the demi pleye in a curtsey of a wide visionary curtain carefully sprinkled with the dust from a fly floor but fly floors are neither flying nor fancying a cup of greasy tea today. A mix up of mayhem in a moving wheel so hold on very tight to a throttle. Wings waiting wingspans willing writing. And a dose of the juice from a pebble is equivalent to a tiny piece of emblematic cereal of wild and strong oats. Oats can operate even in a smoky room. Signal then. Left right. And manuscripts manoeuvre well in a basket of breads, manure, and fingers plus toes of an eel. Hahaha blossoming bacon hahaha burping baboon bringing bananas xxxxx empennage Z z z z z Z z Z z
Copyright © Taoi Chanan | Year Posted 2017
Now lightly sweep the peppercorns in a harbour. No drama. But underground is not a gate nor a post for these are only really ever positioned on hallucinogenic coastal paths where time stands and the pattern ceaseless. Flowing. Great. It is often within hardship that the myth of the writhing cotton bud takes budgets to the ground with a swooping motion. Ejaculations from a sheeted field are never to be confused with a mouse's simple supper of cream crêpe. So skip then. Skip around. Jump up and taste that leaf. Before all is curdled in a gigantic jar of gold. Beast is best at breaststroke and in one solitary splash one can hammer on the web of woven time. Too much about fodder and not enough food. Happen upon a tree? Haha spinning an orbital melon around? Haha power position pointing plays ping pong. Xxxxx insecticidal Z z Z


text:
The best wedding photographers in Sacramento, Lake Tahoe, and Redding, California, available for destination weddings worldwide
We know how much your wedding photography will mean to you in the years to come.
That's why we bring you our trusted Hotlist of the best wedding photographers in Northern California
and around the world so you can choose your wedding photographer with confidence!
That's why we bring you our trusted Hotlist of the best wedding photographers in Northern California
and around the world so you can choose your wedding photographer with confidence!
A gifted photojournalist with extensive experience and a wedding photographer extraordinaire, Kris Holland is sought after by savvy brides and editors everywhere. His relaxed, storytelling style strikes a perfect note for couples who want to enjoy their day naturally, while feeling confident he's got them covered from beginning to end. You'll find beautiful and provocative portraits in his portfolio along with candid moments that will blow your mind and touch your heart, and his delightful personality will make you understand why he is one of the most popular photographers throughout Northern California. Available for travel in the U.S. and abroad.
Creativity and professionalism unite within Andria Lo Photography. Andria has mastered her offering of artful, authentic imagery for the adventurous-at-heart in Northern California and beyond. Her work is bright and bold with utter clarity and refreshing variety; she is able to shoot from varying perspectives and capture interesting compositions from beginning to end. Andria aims to have all her couples feel as though they are completely taken care of, which she does wonderfully with her thoughtful communication and ability to truly listen to her couples. With Andria, it's all about quality photography, capturing the quirk without ever being cheesy. Available worldwide.
Call 510-325-1319
What a ray of sunshine this guy is. Sebastien Bicard is a Frenchman with quite the charming accent - and if that isn't enough to book him, we suppose it's worth mentioning that he's also a super talented, artistically-inclined photographer. He's got enough energy and enthusiasm to lift anyone's spirits or to lower their barriers of insecurity, as he naturally beckons trust and comfort. And the clarity his images possess is truly one-of-a-kind; Sebastien is dynamic in his abilities and creative with his perspective. Sebastien loves a quiet, intimate elopement, complete with a beautiful scenery and the love between two people. These are the only ingredients he needs to create astounding, moving photographs.
Call 916.666.1328
Husband and wife team, Jeff and Dori, are sure to brighten up your day with their fun loving personalities and downright breathtaking photography. With a heavy emphasis on the beauty of nature, Jeff and Dori truly complement their couples with romantic lighting and lush scenery. Taking advantage of the pure ecstasy shared on your big day, this dynamic duo are sure to capture every last tear jerking moment as well as the laughs and festivities. While they are based in Santa Cruz, they are willing to travel abroad to capture your happily ever after.
Call 831.566.1702
Calling California's Central Valley home, Greg Petersen consistently finds inspiration through nature and the adventures it offers. As a photographer, Greg is drawn to shooting weddings that break the mold and stray from tradition. His love for storytelling allows him to act as an observer, giving you space and freedom to enjoy the time with those you love on that incredibly special day. His imagery is full of gorgeous woodland and oceanfront locations, utilizing natural light and the shadows it creates. His romantic compositions and deep, contrasting hues bring an artistry to the images that will forever encapsulate those precious moments. Available across California and worldwide.
Visit http://gregpetersen.co
Call 209.380.4777
The passionate, inviting spirit of Anni Graham helps her clients to come alive and demonstrate their true selves in front of the camera. From start to finish it will feel as though you've been friends for ages, as she captures the real emotions and energy between you and your significant other. It is evident Anni continuously finds inspiration through the nature and environment around her, as her shooting style is calm, relaxed, and authentic. She's a thoughtful, warm person who genuinely respects the significance of your day. No awkward posing or forceful direction; just the honest interactions of you and your loved ones, packaged as beautifully ethereal and artistic images.
Visit http://annigraham.com
Call 360.930.2721
From an early age, Deborah Coleman was aware of her destiny to become an artist. Now, this multi-award winning, experienced professional is known for turning your wedding moments into personalized pieces of art. Her extensive background in photojournalism has given her the incredible ability to capture the best candid moments in the most unobtrusive way. She brings her friendly personality and delightful presence to each wedding she attends, capturing all of the natural, fleeting moments that make up your big day. Deborah will listen to and deliver your vision, and the end result will be everything you imagined and more. For timeless yet unique images, you cannot go wrong with Deborah Coleman of Northern California.
Call 925-408-9179
Vivian Chen is a photographer with a passion for the adventure of travel, nature, and intimate weddings that embrace and celebrate the two. Shooting weddings since 2006, her relaxed demeanor and wedding know-how are the perfect gifts for any stressed bride or groom. Not to mention, her timeless imagery full of clean lines, crisp hues, and classic compositions are just as exceptional. Vivian focuses on catching those multiple fleeting, candid moments scattered throughout your day, putting her innate sense of observation to good use. She also magically captures the beauty of natural light and the warmth it provides to any space. Vivian and her undeniable talent are more than prepared to deliver the wedding photos of your dreams, be that in the Bay Area or anywhere across the globe.
Call 510.579.3477
Highly sought-after wedding photographer Heather Elizabeth creates photos with a dramatic, cinematic feel that look like they belong on the cover of Rolling Stone. Her clients simply mean the world to her, and her passion revolves around exceeding their expectations at every turn. Accepting a limited number of weddings each year so she can spend quality time getting to know each couple she works with, her art is a true reflection of her love for them and their unique styles and personalities. A trend setter who cares much about more what's real and compelling than she does about what's popular, Heather shoots from the heart while using her extensive experience and talent to create extraordinary imagery that truly stands out from the crowd.
Call 209-914-5026
They say a picture's worth a thousand words - but few images carry the kind of weight that can be felt in those created by Dustin Cantrell. Artfully balancing light, shadows, color and darkness, Dustin's images are intimate and dramatic, evoking the kind of emotion that can only be expressed by a couple in love. Dustin is a California native with a vagabond spirit that's taken him on adventures around the globe. His travels have helped inspire, influence and evolve his technique and distinctive style. Dustin shoots weddings across California and would love to travel to your dream destination to document your most treasured day.
Call 661-345-2451
We've searched high and low for the best wedding vendors and inspiration for your Northern California wedding. Looking for more Northern California wedding inspiration? Search through our fabulous Northern California real weddings to inspire your big day!
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Lorain, Ohio Estate Planning Lawyers
Scott W. Paris
Elyria, OH Estate Planning Attorney.
(440) 252-4025University of AkronOhio State University - Columbus6th Circuit, Ohio and U.S. Supreme Court
Neil Spike Esq
Elyria, OH Estate Planning Attorney.
(440) 324-5353University of Miami School of Law and The University of Toledo College of LawCleveland State University and Ohio State University - ColumbusOhio, Florida and United States Tax CourtOhio State Bar
Alan William Anderson Esq
Amherst, OH Estate Planning Attorney.
(440) 988-7918University of ToledoOhio Northern UniversityOhio, Federal Circuit and U.S. Supreme CourtAmherst Lions Club and Ohio State Bar
Andrea Christine Kryszak Esq
Sheffield Village, OH Estate Planning Attorney.
(888) 934-5330Cleveland State UniversityOhioOhio State Bar
Patrick C. Mackin
Avon Lake, OH Estate Planning Attorney.
Ohio, 6th Circuit, U.S. Tax Court, Florida and Indiana
Scott Jancura Esq
Sheffield Lake, OH Estate Planning Attorney.
(440) 949-1750OhioOhio State Bar
Julia B. Szabo
Lorain, OH Estate Planning Attorney.
Susan Miller Weaver Esq
Fairview Park, OH Estate Planning Attorney.
(216) 373-2555Cleveland State UniversityCase Western Reserve UniversityOhioNorthern Ohio LiveCuyahoga County Bar Association and Cuyahoga County Bar Association - Trustee, Section of Domestic RelationsGetting Out, A Divorce Manual for Men and Getting Out, A Divorce Manual for Women
Daniel Seink Esq
Cleveland, OH Estate Planning Attorney.
(800) 393-2324Cleveland State UniversityJohn Carroll UniversityOhio and OhioLife Care Planning Law Firms Association, National Academy of Elder Law Attorneys, OH Chapter...Medicaid, Ohio Elder Law Handbook, 5th Edition and Medicaid, Ohio Elder Law Handbook, 4th Edition
Howard Steven Rabb Esq
Cleveland, OH Estate Planning Attorney.
(216) 861-4211Cleveland State UniversityOhioCleveland Metropolitan Bar Association and University Hospitals Center for Emergency Medicine Leadership CouncilInside the Minds – Trends in Consumer Bankruptcy Filings
Scott W. Paris
(440) 252-4025
Elyria, OH Estate Planning Attorney
13 years experience
13 years experience
Maria Shinn Esq
Cleveland, OH Estate Planning Attorney.
(216) 228-4791Cleveland-Marshall College of LawMuskingum CollegeOhioVNA Cleveland Hospice and VNA Cleveland HospiceOhio State Bar, West Shore Bar Association...
Melvyn Resnick Esq
Cleveland, OH Estate Planning Attorney.
(216) 861-4211Case Western Reserve University School of LawOhioLake County Bar Association
Anthony M Rifici Esq
Westlake, OH Estate Planning Attorney.
(440) 899-7710Cleveland-Marshall College of LawOhioLorain County Bar Association, Department of Veterans Affairs ...
Joan M. Burda
Lakewood, OH Estate Planning Attorney.
(216) 832-8825Pepperdine University School of LawBowling Green State UniversityOhioNational Lesbian and Gay Bar Association and American Bar AssociationEstate Planning for Same-Sex Couples, Second Edition and Representing Gay, Lesbian and Transgender Clients
Ronald R. Stanley
Medina, OH Estate Planning Attorney.
(330) 952-1415Cleveland State UniversityFederal Circuit, Ohio and 6th CircuitOhio State Bar and Medina County Bar Association
Benjamin F. Farah Esq
Rocky River, OH Estate Planning Attorney.
(440) 331-0801Case Western Reserve University School of LawOhioOhio State Bar
Erin Adams Armstrong Esq
Cleveland, OH Estate Planning Attorney.
(216) 385-2519The Ohio State University Michael E. Moritz College of LawUniversity of Notre DameOhioOhio State Bar and Cleveland Metropolitan Bar Association
Kimberly K. Yoder Esq
Rocky River, OH Estate Planning Attorney.
(216) 767-5055Cleveland State UniversityBowling Green State UniversityOhio and 6th CircuitOhio State Bar Association, Cuyahoga Criminal Defense Lawyers Association...
Margaret Karl Esq.
Berea, OH Estate Planning Attorney.
Cory David Hoffman
Huron, OH Estate Planning Attorney.
(419) 602-0323Cleveland State UniversityBowling Green State UniversityOhioOhio State Bar
The LII Lawyer Directory contains lawyers who have claimed their profiles and are actively seeking clients. Find more Lorain, Ohio Estate Planning Lawyers in the Justia Legal Services and Lawyers Directory which includes profiles of more than one million lawyers licensed to practice in the United States, in addition to profiles of legal aid, pro bono and legal service organizations.


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Deals (1)
About this Business
- HoursSunClosedMon-Fri9:00 AM - 5:00 PMSatClosed
From Our Editors
Hoover's Parish Vein Laser Dermatology offers almost any service you need in this spacious salon. Dream up your new style with their talented team. Battling dry or broken out skin? Try one of the many skin treatments at this salon. Botox are just some of the injections this salon has to offer. This medical facility offers dermatology, as well as other beneficial treatments and services. Smooth and healthy skin starts with Parish Vein Laser Dermatology's hair removal services. The doctors at Parish Vein Laser Dermatology will leave you feeling more confident than ever before!


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452 W Wind Dr,Villa Rica GA, 30180
3 beds , 2 Full baths
1,357 sq. ft
Status: Active
Berkshire Hathaway HomeServices Georgia Properties
(770) 355-5995
Last Updated: 2/21/2017 12:02 PM
Description for 452 W Wind Dr Villa Rica, GA 30180
Beautiful 3br/2ba ranch home only 3 miles from I20. Home is updated throughout with new hardwood flooring in living room, kitchen, hall, and master bedroom. Bathrooms have been updated with beautiful tile floors, new fixtures, beadboard, cabinets, and trim. Enjoy rocking on your front porch or relaxing on the back deck that overlooks a large, private backyard that backs up to wooded area. Includes unfinished basement with storage and room for a gym, man cave, etc. Home sits on .46 acres in a quiet, well maintained subdivision with private "resident only" fishing ponds.
Listing Information
Four Winds
Electric Water Heater, Public Water Service
Holding Tank
School Information
Room Information
First Floor Bedroom, Master Bedroom on Main
Breakfast Area
Hookups in Hall
Breakfast Area, Cabinets Stain, Counter Top - Stone
Dual Sinks, Combined Tub/Shower
Interior Features
Dishwasher, Electric Oven, Garbage Disposal
Central Air, Heat Pump, Ceiling Fan(s)
Electric Heating
Partial, Unfinished Basement
Thermal Window
1, Gas logs
Alarm -Smoke/Fire
His & Her Closets, Ceilings Trey
Exterior / Lot Features
2 Car Garage, Drive Under/Built-In
Vinyl, Aluminum
Deck, Front Porch
.46, 1/3 to 1/2 Acre
Sloped, Level
Lake Access, Fishing, Lake Front, Paved Road, Level, Sloped
Financial Considerations
Inside AccessTM
Current market conditions for 452 W Wind Dr
Active Market Trends
Source:MLS DATA
Median list price$194,850
Days on market102
Properties for sale257
Sold Market Trends
Source:MLS DATA
Median sold price$147,900
Sales to list price9,827.0%
Properties sold171
Median sq ft price$77
Arrows indicate 90 day trend
Listing Price History for 452 W Wind Dr
Villa Rica Real Estate
Villa Rica is located in Georgia. Villa Rica, Georgia 30180 has a population of 13,692.
The median household income in Villa Rica, Georgia 30180 is $53,360. The median household income for the surrounding county is $46,704 compared to the national median of $53,046. The median age of people living in Villa Rica 30180 is 31.9 years.
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(770) 355-5995
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text:
Fresh from the Bungo channel, this Michelin rated gem in Ginza specializes in serving blowfish dishes. A premier seafood in Japan and a rare find around the world, this delicacy requires restaurants to have a special license in order to serve due to poison risks. If you're new, the calming interior will put any nerves at ease as you settle in for this must have experience. The most famous and traditional dish is the Blowfish Sashimi, but other varieties – like fried and hotpot – are available a la carte and definitely worth the try. The adventure doesn't stop there as you can also enjoy soft-shell turtle soup and eels at Fukuji. Heralded by many as the best blowfish in Tokyo, this is one draw you don't want to pass up. Be prepared to shell out well over $250 USD or 26,000 Yen for the full experience.
- Price$ $ $ $
- Call+03 5148 2922
- Websitehttp://www.fukuji.jp/
- HoursMon – Fri : 05:00pm - 11:00pm
- TypeRestaurant
- SpecialtyBlowfish


text:
Urothelial carcinoma of the bladder (UCB) is genomically heterogeneous, with frequent alterations in genes regulating chromatin state, cell cycle control, and receptor kinase signaling. To identify prognostic genomic markers in high-grade UCB, we used capture-based massively parallel sequencing to analyze 109 tumors. Mutations were detected in 240 genes, with 23 genes mutated in ≥5% of cases. The presence of a recurrent phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutation was associated with improved recurrence-free survival (RFS) (hazard ratio [HR]: 0.35; p = 0.014) and improved cancer-specific survival (CSS) (HR: 0.35; p = 0.040) in patients treated with radical cystectomy (RC). In multivariable analyses controlling for pT and pN stages, PIK3CA mutation remained associated with RFS (HR: 0.39; p = 0.032). The most frequent alteration, TP53 mutation (57%), was more common in extravesical disease (69% vs 32%, p = 0.005) and lymph node–positive disease (77% vs 56%, p = 0.025). Patients with cyclin-dependent kinase inhibitor 2A (CDKN2A)–altered tumors experienced worse RFS (HR: 5.76; p < 0.001) and worse CSS (HR: 2.94; p = 0.029) in multivariable analyses. Mutations in chromatin-modifying genes were highly prevalent but not associated with outcomes. In UCB patients treated with RC, PIK3CA mutations are associated with favorable outcomes, whereas TP53 and CDKN2A alterations are associated with poor outcomes. Genomic profiling may aid in the identification of UCB patients at highest risk following RC.
Patient summary
Using next-generation sequencing, we identified genomic subsets of high-grade urothelial bladder cancer associated with favorable and unfavorable outcomes. These findings may aid in the selection of patients most likely to benefit from novel combined modality approaches.
Keywords: Bladder cancer, Genomics, Clinical outcomes, PIK3CA, Mutation.
Despite multimodality treatment, patients with bladder cancer who undergo radical cystectomy (RC) remain at high risk for recurrence. We hypothesized that the significant variability in outcomes of patients with urothelial carcinoma of the bladder (UCB) partly results from differences in the genetic changes mediating UCB development and progression [1], [2], [3], and [4]. With the goal of identifying prognostic genomic alterations, we used capture-based next-generation sequencing to analyze high-grade UCB tumors for somatic mutations in cancer-associated genes.
Tissue samples and matched germline blood from 109 patients with high-grade UCB were sequenced using MSK-IMPACT, as previously described (details in Supplemental Materials and Methods) [5]. Cohort characteristics are listed in Supplemental Table 1. Average sequence coverage was 579× across all targeted exons. An average of 10 mutations was detected per tumor (range: 0–46). Mutations were detected in 240 genes, with 23 genes mutated in ≥5% of cases (Fig. 1). As validation, we reanalyzed all samples using an orthogonal sequencing platform including all coding exons of STAG2, KDM6A, ARID1A, and KMT2D (also known as MLL2). Using this method, the vast majority of mutations in these genes identified by MSK-IMPACT (99.3%) were confirmed.
Most commonly altered genes in 109 high-grade urothelial carcinoma of the bladder tumors analyzed by MSK-IMPACT. The number of patients with alterations is depicted on the right. Alterations were categorized by type, as recurrent missense mutations, novel missense mutations, truncating mutations (frameshift, nonsense, and splice site), and copy number amplifications or deletions. The oncoprint shows the distribution of alterations across the sequenced samples. The top bar graph illustrates the number of MSK-IMPACT gene alterations per sample.
We analyzed mutations and copy number alterations independently and in the context of cancer-related pathways. The most common alteration was TP53 mutation, identified in 62 patients (57%) (Supplemental Fig. 1a). Alterations in genes that regulate entry into the S phase of the cell cycle were also prevalent (46%) (Supplemental Fig. 1b). Consistent with previous reports, mutations in chromatin-modifying genes (CMGs) were highly prevalent, occurring in 83% of patients (Supplemental Fig. 1c) [1], [2], and [3]. KDM6A was mutated in 45 patients (41%), with 41 of 45 truncating mutations. ARID1A alterations (28%), similarly enriched for truncating mutations (30 of 31), were mutually exclusive with SMARCA4 alterations, suggesting potential overlapping functionality. The histone acetyltransferase genes CREBBP and EP300 also exhibited a pattern of mutually exclusive truncating mutations (13% and 15%, respectively).
Alterations in the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt signaling pathway, mutationally activated in many cancers, are potential therapeutic targets in UCB [4]. We identified PI3K/Akt pathway alterations in 38 patients (35%) (Supplemental Fig. 2a) Recurrent missense mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), which encodes the α subunit of PI3-kinase, were detected in 23 patients (21%); the vast majority of the mutations were functionally validated activating helical domain mutations (Supplemental Fig. 2b). Additional recurrently mutated PI3K/Akt pathway genes included PTEN (6%), AKT1 (2%), and TSC1 (6%).
To identify prognostic genomic markers, we analyzed associations between alteration status, clinicopathologic characteristics, and outcomes in 89 patients whose tumors were obtained at RC. For these analyses, we included 22 alterations (Supplemental Table 2) with putative functional significance (oncogenes: recurrent missense mutations and amplifications; tumor suppressors: nonsense mutations, frameshift indels, and deletions). TP53 mutations were more common in extravesical than organ-confined disease (69% vs 32%; p = 0.005), and p53 pathway alterations were more common in node-positive disease (77% vs 56%; p = 0.025) (Supplemental Table 2).
The presence of a recurrent missense mutation in PIK3CA was associated with significantly improved recurrence-free survival (RFS) and cancer-specific survival (CSS) (p = 0.014 and 0.040, respectively) (Fig. 2a). A similar improvement was observed on analyzing PI3K/Akt pathway genes as a functionally related group (hazard ratio [HR]: 0.34, p = 0.006 and HR: 0.29, p = 0.01) (Fig. 2b). After controlling for pT stage and nodal involvement, PIK3CA mutation and PI3K/Akt pathway alteration remained significant predictors of improved RFS (HR: 0.39, p = 0.032 and HR: 0.37, p = 0.017, respectively) (Supplemental Table 3). It is notable that PIK3CA alterations have been associated with favorable disease-specific outcomes in other malignancies [6] and [7]. Although their disease-specific outcomes were relatively favorable, UCB patients with PIK3CA-mutant tumors still experienced a significant rate of disease recurrence (44% at 5 yr). Adjuvant trials of selective PI3-kinase inhibitors in this genetically defined subset of patients would thus be rational.
Associations with PI3K/Akt pathway alterations and clinical outcomes in 89 patients with urothelial carcinoma of the bladder treated with radical cystectomy. Recurrence-free survival and cancer-specific survival stratified by (A) PIK3CA mutation status and (B) PI3K/Akt pathway alteration status. The p values reflect the log-rank test.
Patients with p53 pathway alterations had worse RFS (HR: 1.92; p = 0.048) and CSS (HR: 2.94; p = 0.013), but these numbers did not remain statistically significant after adjustment for pT and pN stages (Supplemental Table 3). Patients with cyclin-dependent kinase inhibitor 2A (CDKN2A) alterations experienced worse RFS and CSS in multivariable analyses (HR: 5.76, p < 0.001 and HR: 2.94, p = 0.029, respectively). The significantly poor outcome of patients with CDKN2A-altered tumors provides rationale for the study of selective CDK4 inhibitors in this genomic subgroup.
We identified higher CMG mutation rates than previously reported [1]. Methodological differences may account for this outcome, as our deep sequencing approach (mean coverage: 579×) likely provided greater sensitivity. However, we did not find an association between CMG mutations and outcomes. Given the presence of these mutations in nearly all UCB tumors (83% in this series), we speculate that epigenetic alterations may be necessary events in UCB pathogenesis, and thus CMG mutations are not associated with outcomes.
Studies investigating the prognostic significance of alterations in the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in UCB have reported contradictory findings. In one study, STAG2 alterations were associated with worse survival [2]; another study found that loss of STAG2 expression was associated with worse disease characteristics and outcomes following RC [8]. In contrast, a third study reported that loss of STAG2 expression was associated with improved outcomes [9]. In our study, we observed no association between STAG2 mutations and outcomes.
Given the genomic heterogeneity of bladder cancer, one limitation of the current study is its sample size. We may have also underestimated the genetic variation present within individual tumors by sampling a single site. Although our assay included all highly mutated genes identified by recent whole exome studies, less frequently mutated genes and structural alterations were not detectable with our capture-based approach. Finally, our targeted DNA sequencing approach does not address epigenetic differences and/or differences in gene expression [10]. Given these limitations of the current study, a larger and more comprehensive analysis may identify co-mutation patterns that are more predictive of disease outcome.
In summary, we performed capture-based next-generation sequencing in a large cohort of high-grade UCB patients with the goal of identifying prognostic genomic alterations. Patients with TP53-mutant tumors experienced worse outcomes, but TP53 mutations were not significantly associated with outcome in multivariable analyses, given their association with locally advanced and/or node-positive disease. In contrast, PIK3CA and/or PI3K/Akt pathway alterations were associated with improved disease-specific outcomes independent of tumor and lymph node stage, whereas CDKN2A alterations were independently associated with worse outcomes. These findings, pending validation, may inform patient selection for novel combined modality approaches.
Author contributions: Bernard H. Bochner had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Kim, Cha, Iyer, Al-Ahmadie, Solit, Bochner.
Acquisition of data: Kim, Cha, Sfakianos, Sun, Yee, Al-Ahmadie.
Analysis and interpretation of data: Kim, Cha, Sfakianos, Iyer, Zabor, Scott, Ostrovnaya, Ramirez, Shah, Schultz, Berger, Solit, Bochner.
Drafting of the manuscript: Kim, Cha, Solit, Bochner.
Critical revision of the manuscript for important intellectual content: Kim, Cha, Sfakianos, Iyer, Zabor, Berger, Al-Ahmadie, Solit, Bochner.
Statistical analysis: Zabor, Ostrovnaya.
Obtaining funding: Solit, Bochner.
Administrative, technical, or material support: None.
Supervision: Ostrovnaya, Reuter, Bajorin, Rosenberg, Berger, Solit, Bochner.
Other (specify): None.
Financial disclosures: Bernard H. Bochner certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: None.
Funding/Support and role of the sponsor: The design and conduct of this study and the collection, management, analysis, and interpretation of the data were funded by the National Institutes of Health, the Michael and Zena Wiener for Therapeutics Program in Bladder Cancer, Cycle for Survival, and Pin Down Bladder Cancer.
Appendix A. Supplementary data
- [1] Y. Gui, G. Guo, Y. Huang, et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet. 2011;43:875-878 Crossref
- [2] G. Guo, X. Sun, C. Chen, et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet. 2013;45:1459-1463
- [3] Cancer Genome Atlas Research, Network. Comprehensive molecular characterization of urothelial bladder, carcinoma. Nature. 2014;507:315-322
- [4] G. Iyer, H. Al-Ahmadie, N. Schultz, et al. Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. J Clin Oncol. 2013;31:3133-3140 Crossref
- [5] N. Wagle, M.F. Berger, M.J. Davis, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov. 2012;2:82-93 Crossref
- [6] K. Kalinsky, L.M. Jacks, A. Heguy, et al. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res. 2009;15:5049-5059 Crossref
- [7] H. Shigaki, Y. Baba, M. Watanabe, et al. PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. Clin Cancer Res. 2013;19:2451-2459 Crossref
- [8] D.A. Solomon, J.S. Kim, J. Bondaruk, et al. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013;45:1428-1430
- [9] C. Balbas-Martinez, A. Sagrera, E. Carrillo-de-Santa-Pau, et al. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet. 2013;45:1464-1469
- [10] G. Sjodahl, M. Lauss, K. Lovgren, et al. A molecular taxonomy for urothelial carcinoma. Clin Cancer Res. 2012;18:3377-3386 Crossref
a Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
b Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
c Weill Medical College of Cornell University, New York, NY, USA
d Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
e Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
f Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
g Department of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Corresponding author. Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Tel. +1 646 422 4387; Fax: +1 212 988 0759.
These authors contributed equally.
Article information
DOI: 10.1016/j.eururo.2014.06.050
© 2014 European Association of Urology, Published by Elsevier B.V.


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Function 1.Remove nitrogenous wastes 2.Maintain electrolyte, acid-base, and fluid balance of blood 3.Homeostatic organ 4.Acts as blood filter 5.Release hormones: calcitriol & erythropoietin
Kidneys as Filters Diuretic- lose water; coffee, alcohol Antidiuretic- retain water; ADH Aldosterone- sodium & water reabsorption, and K + excretion GFR= 180 liters (50 gal) of blood/day liters are reabsorbed back into blood Excrete a protein free filtrate
Renal Artery Segmental Arteries Interlobar Arteries Arcuate Arteries Cortical Radiate Arteries Afferent Arterioles Glomerular Capillaries Efferent Arterioles Peritubular Capillaries Cortical Radiate Vein Arcuate Veins Interlobar Veins Renal Veins
consist of a long tubule & a ball of capillaries called a glomerulus the end of the tubule that surrounds the glomerulus is called Bowman's capsule the remaining parts of the tubule are called the: proximal tubule loop of Henle distal tubule the tubule empties into a collecting duct that leads to the renal pelvis the renal pelvis opens to the ureter Nephron
Each kidney contains over 1 million nephrons and thousands of collecting ducts Nephron
Nephron's functions: 1.glomerular filtration 2.tubular reabsorption 3.tubular secretion
Histology of a renal corpuscle
Pressures that drive glomerular filtration
The filtration membrane
Composition of Glomerular Filtrate Water Small Soluble Organic Molecules Mineral Ions
Boman's Capsule filtration occurs as blood pressure in the capillaries of the glomerulus forces filtrate into Bowman's capsule the process is passive (diffusion) the filtrate includes: water, salts, bicarbonate (HCO 3 – ), H +, urea, glucose, amino acids
Proximal Convoluted Tubule Reabsorbs: water, glucose, amino acids, and sodium. 65% of Na + is reabsorbed 65% of H 2 O is reabsorbed 90% of filtered bicarbonate (HCO 3 - ) 50% of Cl - and K +
Loop of Henle Creates a gradient of increasing sodium ion concentration towards the end of the loop within the interstitial fluid of the renal pyramid. 25% Na+ is reabsorbed in the loop 15% water is reabsorbed in the loop 40% K is reabsorbed in the loop
Loop of Henle: Descending Limb is impermeable to salts but permeable to water as filtrate moves through the descending limb, water steadily moves out making the filtrate more & more concentrated this occurs because the osmolarity (salt concentration) of the interstitial fluid in the renal medulla becomes increasingly greater the further down you go
Loop of Henle: Ascending Limb is permeable to salts but impermeable to water as filtrate moves through the ascending limb, NaCl moves out making the filtrate more & more dilute basically, the purpose of the loop of Henle is to keep the renal medulla region of the kidney at a high osmolarity so water can move passively out of the filtrate in the collecting duct (as we'll see shortly)
Distal Convoluted Tubule Under the influence of the hormone aldosterone, reabsorbs sodium and secretes potassium. Also regulates pH by secreting hydrogen ion when pH of the plasma is low. only 10% of the filtered NaCl and 20% of water remains
ADH Antidiuretic hormone: Produced by posterior pituitary Targets collecting ducts to be more permeable to water Results in more concentrated urine
Collecting Duct Allows for the osmotic reabsorption of water. the collecting duct carries the remaining filtrate back through the renal medulla which is now very high in salt (high osmolarity) as the filtrate passes through the collecting duct, water can passively move out how much water moves out depends on the amount of water needed by the body this is controlled by the hormone ADH
From the original 1800 g NaCl, only 10 g appears in the urine Urine Water- 95% Nitrogenous waste: urea uric acid creatinine Ions: sodium potassium sulfate phosphate
Nitrogenous Wastes Proteins Amino acids COOH -NH 2 Ammonia Urea Uric Acid
Hormonal Control of Kidney Function
Hormonal Control of Kidney Function hypothalamus posterior pituitary antidiuretic hormone collecting ducts
Fig Regulation of Aldosterone secretion by renin-angiotensin- aldosterone (RAA) pathway
Hormonal Control of Kidney Function reduced blood pressure and glomerular filtrate juxtaglomerular apparatus renin
Hormonal Control of Kidney Function renin angiotensinogen angiotensin I angiotensin II
Hormonal Control of Kidney Function adrenal cortex aldosterone angiotensin II convoluted tubules
Urinary Bladder ureters internal sphincters external sphincters urethra
Bladder 1.Mucosa (transitional epithelium) 2.Muscular layer (detrusor muscle): 3 layers of smooth muscle 3.Fibrous adventia
Internal urethral sphincter: Smooth muscle Involuntary control More superiorly located External Urethral sphincter: Skeletal muscle Voluntary control Posteriorly located Sphincter Muscles on Bladder
When bladder fills with 200 ml of urine, stretch receptors transmit impulses to the CNS and produce a reflex contraction of the bladder (PNS) Diuresis (Micturition) When is incontinence normal?
Why do doctors ask for a urine sample? Urinalysis characteristics: smell- ammonia-like pH , ave 6.0 specific gravity– more than 1.0; ~ color- affected by what we eat: salty foods, vitamins
odor- normal is ammonia-like diabetes mellitus- smells fruity or acetone like due to elevated ketone levels diabetes insupidus- yucky asparagus--- Odor
pH- range ave 6.0 vegetarian diet- urine is alkaline protein rich and wheat diet- urine is acidic
Color- pigment is urochrome Yellow color due to metabolic breakdown of hemoglobin (by bile or bile pigments) Beets or rhubarb- might give a urine pink or smoky color Vitamins- vitamin C- bright yellow Infection- cloudy Color
Water: s.g. = 1g/liter; Urine: s.g. ~ to Specific Gravity When urine has high s.g.; form kidney stones Diabetes insipidus- urine has low s.g.; drinks excessive water; injury or tumor in pituitary
Normal Constitutes of Urine
Glucose- when present in urine condition called glycosuria (nonpathological) [glucose not normally found in urine] Indicative of: Excessive carbohydrate intake Stress Diabetes mellitus Abnormal Constitutes of Urine
Albumin-abnormal in urine; it's a very large molecule, too large to pass through glomerular membrane > abnormal increase in permeability of membrane Abnormal Constitutes of Urine
Albuminuria- nonpathological conditions- excessive exertion, pregnancy, overabundant protein intake-- leads to physiologic albuminuria Pathological condition- kidney trauma due to blows, heavy metals, bacterial toxin Abnormal Constitutes of Urine
Ketone bodies- not normal in urine Ketonuria- find during starvation, using fat stores Ketonuria is couples w/a finding of glycosuria-- which is usually diagnosed as diabetes mellitus RBC-hematuria Hemoglobin: Hemoglobinuria- due to fragmentation or hemolysis of RBC; conditions: hemolytic anemia, transfusion reaction, burns or renal disease Abnormal Constitutes of Urine
Bile pigments- Bilirubinuria (bile pigment in urine)- liver pathology such as hepatitis or cirrhosis WBC- Pyuria- urinary tract infection; indicates inflammation of urinary tract Casts- hardened cell fragments, cylindrical, flushed out of urinary tract WBC casts- pyelonephritus RBC casts- glomerulonephritus Fatty casts- renal damage Abnormal Constitutes of Urine
INQUIRY 1.List several functions of the kidneys. 2.What does the glomerulus do? 3.What are several constitutes you should not find in urine? 4.What is specific gravity? 5.What two hormones effect fluid volume and sodium concentration in the urine? 6. Where are the pyramids located in the kidney? 7.What vessel directs blood into the glomerulus? 8.Where does most selective reabsorption occur in the nephron?
Moment of Zen KIDNEY
Moment of Zen
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Düven Hotel, Nevsehir
- Free buffet breakfast, free WiFi, and free parking
Main amenities
- 14 guestrooms
- Restaurant and bar/lounge
- Airport shuttle
- Terrace
- 24-hour front desk
- Daily housekeeping
- Free grocery shopping service
- Laundry service
- Barbecue grills
- Free newspapers in the lobby
- Tour/ticket assistance
For families
- Cribs/infant beds (surcharge)
- Rollaway/extra beds available
- Sofa bed
- Refrigerator
- Private bathroom
- Separate dining area
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- In Uchisar
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- Cross Golf (0.1 mi / 0.2 km)
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At a glance
Key facts
Hotel size
- This hotel has 14 rooms
- 24-hour check-in
- Check-out time is 12:30 PM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed
- Restrictions apply *
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi and wired Internet access in public areas
- Free WiFi in rooms
- Airport shuttle (available on request) *
- Free extended parking
- Free nearby parking
Nearby Three Star Nevsehir hotels
In the hotel
- Free buffet breakfast daily
- Restaurant
- Bar/lounge
- Coffee shop/café
- Room service
- Barbecue grills
- Golfing nearby
- 24-hour front desk
- Tours/ticket assistance
- Dry cleaning/laundry service
- Free grocery shopping service
- Free newspapers in lobby
- Designated smoking areas
- Terrace
In the room
- Coffee/tea maker
- Iron/ironing board (on request)
- Washer/dryer
- Sofa bed
- Sofa bed size double
- In-room massage available
- Fireplace
- Separate dining area
- Separate living room
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- Plasma TV
- Satellite TV channels
- Free newspaper
- Free WiFi
- Phone
- Refrigerator
- Daily housekeeping
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DiningOnsite venue - This restaurant specializes in regional cuisine and serves breakfast only.
Düven Hotel, Nevsehir's small print
Also known as
- Düven
- Düven Hotel
- Düven Hotel Nevsehir
- Düven Nevsehir
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation.
Optional extras
Cribs/Infant beds are available for an extra charge
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Good 3.8 /5 from 5 reviews
Room is big but basic. Every room has a big window either opening in a central courtyard or opening to the beautiful view of the valley. Very nice view from the breakfast cafe. Breakfast was a bit basic though, addition of fruits and getting a cook who can actually make a decent omelette would be a start :) Staff are very friendly and helpful. Also they need to install come sort of ventilation in the washroom maybe extraction fans.
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46 CFR 78.60-1 - Master or person in charge responsible.
(a) It shall be the duty of the master or other person in charge of the vessel to see that all of the provisions of the certificate of inspection are strictly adhered to. Nothing in this subpart shall be construed as limiting the master or other person in charge of the vessel, at his own responsibility, from diverting from the route prescribed in the certificate of inspection or taking such other steps as he deems necessary and prudent to assist vessels in distress or for other similar emergencies.
(b) [Reserved]
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Tanisha Singh News
Are Rahul Gandhi and Narendra Modi being used by small time models?
Two desperate damsels drop their clothes and endorse the two poster boys (read men) to gain the much needed attention. Tell us who is hot and who is not- the babes we mean!
We at BollywoodLife found both Meghna Patel and Tanisha Singh not just desperate, but also relentlessly tacky with their dare bare acts. The battle of votes has now turned into an ugly war of stripping where two small time models have dropped their bare essentials to gain the much needed limelight. Click here to read more