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25 Easy to Make Homemade Jewelry Crafts
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Latest Comments
"The Hushabye Shell Afghan is a beautiful blanket that would be a great shower gift. The pattern is an easy shell stitch and the colts are great for a boy or girl. I am sure that it will keep baby nice and warm. It is made with a nice four ply yarn and should work up fast. This one to save for a later date."
"The wavy rainbow baby blanket is one of the cutest that I have seen. The colors are so bright that a baby will enjoy looking at it. The blanket could also be worked up in other colors that would be great for that special little one. this is not for a beginner, so if this is your first try at crocheting you may not want to try it. Looking forward to working on this."
"The Springtime Lace Afghan Pattern is so cute. It will make a great baby blanket for that special baby. This could be made in many different colors that will really be pretty. The pattern reads really easy and a beginner could do this.I am looking forward to to this project in the very near future."
"he Cape Cod Afghan is really a cute pattern. It would be a great one for beginners. The pattern only calls for two skeins of yarn. The pattern reads really easy. This could also be used as a baby blanket and would look great in one of those baby colors. This is one pattern that I will definitely save for a later project down the road."
Christmas Peppermint Bead Bracelet
By: Cindy Overland for Rings & Things
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Celebrate your sweet tooth and Christmas with this red and green peppermint bead bracelet. This Christmas bead craft from Rings & Things is quick and easy to make for gifts or to treat yourself. Also, check out the Christmas Peppermint Charm for your cell phone or other gadgets.
- 6 28-333-60 15x25x8mm handmade lampwork glass mint
- candy beads, green/red/white (limited stock)
- 9" 61-740-01 Petite (size #0) rattail, white (limited stock)
- 1 41-151-98-25-3 2.2mm center-crimp tube with hook, silver plate
- 1 41-151-99-25-3 2.2mm center-crimp tube with loop, silver plate
- scissors
- flat-nose pliers
- String the beads onto petite rattail (or other 1-1.5mm diameter cord), separating the beads with overhand knots (see instructions on back).
- Double over the cord before inserting it into the center-crimp tubes.
- Flatten center-crimp tubes with flat-nose pliers, not crimping pliers.
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Apr 04, 2016
I do love the candy cane beads too. Did anyone find out where you can get them? This is so cute and a great idea for a birthday party also if you could find cupcake beads in place of the candy canes. I will do this bracelet with my granddaughter for Christmas.I know she will go crazy over the candy cane beads. And so simple.
billandlinda101 63 49453
Sep 05, 2011
Luv this craft especially good for a school class project. Where do I find the candy beads?
Jul 25, 2010
I love this bracelet. Where can I buy the "candy" beads? Thanks,
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Culture / Slices
Are you taking a break from binge watching to actually get some work done? Well, Netflix has created yet another distraction to prevent you from doing anything productive. They teamed with The Secret Little Agency to create this "Where's Waldo"-inspired game, featuring a massive image of a park populated by nothing but Netflix characters.
The kids from Stranger Things, the Kimmy Schmidt gang, the Underwoods, they're all there.
Have fun spending even more fleeting moments of your life on Netflix-related entertainment. You can see the full image here. Discuss
Well, this is exciting. Netflix has just released a brief teaser for the new season of their hit sci-fi series Stranger Things. The clip is more about hints and clues than major revelations, but, it's an exciting peak the follow-up to the acclaimed first season.
There's no release date set yet, though according to the clip, it will drop sometime in 2017. Discuss
There's already a lot of bad movies on Netflix, but at least now, there will be a show that's dedicated to making fun of cinema's worst creations. After Mystery Science Theater 3000 creator Joel Hodgson raised more than $7 million on Kickstarter to bring back the beloved '90s comedy series, Netflix has announced that it will be home to a new version of the show, which stars prisoners onboard a spacecraft, who bide their time by watching terrible movies, making jokes the whole time.
The series provides a lot to be excited about. Along with adding Patton Oswalt to the cast, Community's Joel McHale and Dan Harmon are helping to write the new series. There's no word yet on a release date. Discuss
Netflix is going all-in with its Marvel franchises. At San Diego Comic Con this week, the streaming network not only show teasers for the new season of Jessica Jones and the first season of Luke Cage, but also announced that its hit Daredevil would be returning for a third season.
Next stop: Hells Kitchen. #Daredevil Season 3 is coming soon. #MarvelSDCChttps://t.co/hdSmN4mfMv— Marvel Entertainment (@Marvel) July 22, 2016
Next stop: Hells Kitchen. #Daredevil Season 3 is coming soon. #MarvelSDCChttps://t.co/hdSmN4mfMv
The streaming provider has big plans for the shows. In addition to creating another show based on Jon Bernthal's Punisher—who appears in Daredevil—Netflix is also bringing the Hells Kitchen heroes (along with Iron Fist), together, for their own super-team in another series, called The Defenders.
You'll soon have a lot of binge watching to do. Discuss
Netflix has figured out a way to make their service even more addictive. The streaming content provider has just launched a new feature called "Flixtape," which allows you to create, find and share custom playlists, you know, like an old fashion mixtape.
As they explain,
Flixtape is a short playlist of Netflix titles based around a theme, a mood, or message. It's like a mixtape, but for Netflix.
Though Netflix automatically populates the playlists with titles that "capture the vibe you want" and "the feeling you're trying to capture," users can still edit the list with some custom choices. Finally, something to do when the "Pokemon Go" servers get overcrowded. Discuss
Here is a report that will likely come as a surprise to anyone who has seen even moments of Netflix's reboot of the classic TGIF sitcom Full House. The ratings experts Symphony Advanced Media claims that Fuller House is the most popular show on television, drawing more than 14 million viewers. Just for context, that makes the comically bad reboot more popular than mega-hits like The Walking Dead or Game of Thrones.
Netflix, for their part, doesn't release ratings information and has called SAM's methodology for collecting them "remarkably inaccurate" in the past. SAM collects data from smart phone apps that uses audio recognition software to determine what users are watching. The only problem is, it's hard to know how representative of the general population their sample size really is. Also, comparing a show that is binged-watch in a single session or two with a weekly series is problematic for comparisons.
But, even if Fuller House isn't the biggest show on TV, the fact that a massive amount of people spent hours of their life watching a show Vulture called "the most excruciating TV minutes ever broadcast" is truly concerning. Discuss

subset: commoncrawl


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508 Pine Island Circle,Mansfield TX, 76063
3 beds , 2 Full/1 Half baths
2,827 sq. ft
Status: Pending
Berkshire Hathaway HomeServices PenFed Realty Texas
(214) 901-7993
Last Updated: 2/20/2017 4:11 PM
Description for 508 Pine Island Circle Mansfield, TX 76063
MLS# 13303308 - Built by Impression Homes - Ready now! ~ Brand New Home! One story home with 3 Bedrooms + Study in the prominent neighborhood of Cardinal Park. Country life and the conveniences of close restaurants and shopping! Home features fabulous wood flooring, a third car garage and wine grotto! The chef in the family will be thrilled with the gourmet kitchen!! The 3rd car garage is perfect for that extra space needed!
Listing Information
Cardinal Park
Slab Foundation
City Sewer
School Information
Room Information
Interior Features
Other, Gas Range/Cooktop, Dishwasher, Disposal, Oven Gas
Ceramic Tile, Carpet, Wood
Central Air
Other, Other
1, Gas logs
Dry Bar, Vaulted
Exterior / Lot Features
2 Garage Spaces, 3 Parking Spaces, Garage
Less Than .5 Acre (not Zero)
Subdivision, Wooded
Financial Considerations
Inside AccessTM
Current market conditions for 508 Pine Island Circle
Active Market Trends
Source:MLS DATA
Median list price$345,471
Days on market76
Properties for sale188
Sold Market Trends
Source:MLS DATA
Median sold price
Not enough information to display market trend data at this time
Sales to list price
Not enough information to display market trend data at this time
Properties sold216
Median sq ft price$-1
Arrows indicate 90 day trend
Listing Price History for 508 Pine Island Circle
Mansfield Real Estate
Mansfield is located in Texas. Mansfield, Texas 76063 has a population of 55,818.
The median household income in Mansfield, Texas 76063 is $92,208. The median household income for the surrounding county is $56,859 compared to the national median of $53,046. The median age of people living in Mansfield 76063 is 34 years.
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When you trade options, including calls, you are betting not just on the value of the underlying stock, but on the value the option will have to potential buyers. At times, you can make the correct guess on what direction the stock will move, for instance, but the value of the option contract does not move as you expected. The three most significant factors in valuing options are "time decay" and what traders term "the Greeks," particularly Delta and Gamma.
The Basics
A call option is the right to buy a security at a certain price -- known as the strike price -- on or before the option's expiration date, though there is no obligation to do so. At day's end buying a call mimic buying 100 shares of the underlying stock, but at a fraction of the cost. You can overpay for a call. If you do, the option's underlying instrument may move up, but you can still be left with a losing call option position.
Time Decay
Generally, the further away you are from your call's expiration date, the higher its premium. As you get closer to an option's expiration day, the value of the call tends to decline. Options traders refer to this erosion in value over time as "time decay." One way to understand this is to consider an out-of-the-money call option. When a call is out-of-the-money, it's strike price is above the underlying security's market price. As you get closer to options' expiration day, the likelihood that an out-of-the-money call will go in-the-money (the market price will be higher than the strike price) decreases, therefore the value of the call does the same.
In valuing options, traders use five measures of risk -- Delta, Gamma, Vega, Theta and Rho -- known as the Greeks. Of these, Delta might be the most important, at least with respect to how it influences the value of a call. Delta measures the rate of expected change in an option for every one-unit change in the option's underlying security. For instance, if an option's Delta is .70, it will move .70 (or 70%) for each one point move in the underlying equity's share price. A low Delta often indicates that you will need to see large movements in the underlying stock to realize meaningful movements in the value of an option.
Gamma refers the amount of change you can expect in an option's Delta for every one point change in the price of the option's underlying security. For instance, a Gamma of .20 means that Delta will increase by .20 for every one point move in the underlying stock. Because Gamma impacts Delta, a high Gamma indicates that Delta will also increase as the underlying security moves, which means that the value of your option might end up making larger moves as well.
Photo Credits
- Spencer Platt/Getty Images News/Getty Images


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We really love having you listen to RN but we need to let you know that we'll be closing our subject based podcasts (don't worry—we aren't cancelling any shows). To keep hearing stories and interviews from RN, search for your favourite shows in theABC Radio App or subscribe in your preferred podcasting app. If you're looking for something new to wrap your ears around, visit the RN website where there's plenty for you to discover.
May 4th, 2015
Episode 451 of 1612 episodes
Australian Doctors For Africa was established in 2005 as a non -profit volunteer community based organisation. Its goals are to provide medical supplies, equipment, surgical procedures and to teach local medical and hospital staff in East Africa.
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Welcome to the daily audio workout for your head.


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20mm Copper Penny upcycled into original Buttons.
20mm Copper Penny upcycled into original Buttons.
More info: etsy.com
Fred Drn says
Le nerf de la guerre..: des boutons.
Uǝʌǝʇs Sǝppǝƃ says
I'm sure there is a law against damaging money?
Philippe Spitalier says
It's illegal in most countries, but who will sue ?
Uǝʌǝʇs Sǝppǝƃ says
Lol true
This is cool. From a quick Google, I gather it is not illegal if it isn't done for fraudulent purposes. Same for squished penny machines.
Talina Pennington says
Wow love it
Tree Hugger says
Not a bad price either....lol
Rachel Lund says
@marlyce francen @kristina stiffler
Pookie says
I wonder how they dented them?
Ross says
Ball-peen hammer held over a convex anvil... hit with a 5lb dead-weight hammer. Copper is great to work with!
Tammy Russell says
We finally have a use for them!
Cathy Stone Wallace says
Linda says
I am going to try this using my Dremal w the drill press that my husband gave me for my birthday.
Clouds says
They're worthless, how could that be illegal!?
I think it's an awesome idea!
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Diane Kochilas
Meze: Small Plates to Savor and Share from the Mediterranean Table
Книгу можно купить в интернет-магазинах:
· OZON.ru 897р. [Проверить наличие]
ISBN: 0688175112Издательство: Morrow Cookbooks
Год издания: 2003
Страниц: 208
Now you can enjoy the food and fun of a meze feast. Meze, the small plates of just about everything from seafood, meat, and vegetables to handheld pies, colorful salads, nuts, olives, and cheeses, is the food of hospitality and conviviality, food meant to be shared with friends and family and savored with wines and spirits. Here, in Meze , Diane Kochilas, the award-winning author of The Glorious Foods of Greece , chef, restaurateur, and cooking teacher, takes you on a spirited journey across Greece and the rest of the Mediterranean, exploring these simple and simply irresistible dishes. The recipes are robust, dear, and easy to follow. These uncomplicated dishes are charged with flavor and based on fresh, accessible ingredients. The results are spectacular. Meze makes every meal a party, and no one knows how to throw a party better than the Greeks. Youll find tangy, skewered meats and juicy meatballs, delicious seafood dishes from simple steamed mussels to...


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Canyon Overlook Trail is a 1 mile heavily trafficked out and back trail located near Hurricane, Utah that features beautiful wild flowers and is rated as moderate. The trail is primarily used for hiking, walking, nature trips, and birding and is accessible year-round.
kid friendly
nature trips
wild flowers
no dogs
Canyon Overlook Trail is a moderate out and back 1 mile RT offering some of the most breathtaking shots of Zion Canyon ever photographed. The trail itself short and not steep; the elevation gain is 100 ft between the parking lot and the viewpoint. The trailhead is a collection of stone steps that ascend the stone ridge directly above north side of road, across the street from the parking lot. The trail passes through shaded alcoves with ferns and trees, across a planked boardwalk and through a moist grotto, and over bare slickrock, wandering its way to edge of impressive cliff overlook. The expanse of Zion Canyon is open before Overlook, with its monumental formations visible on either side of canyon. You can see the road as it switchbacks below the west end of the Mount Carmel Tunnel. The West Temple, Towers of the Virgins, Streaked Wall, and Beehives all make up part of this tremendous view. The East Temple rises directly above the Overlook, towering more than 2,200 ft above the canyon floor. The Great Arch lies recessed into the cliff-face below the Overlook, carving its way through eons into solid sandstone. the TH can be reached by following Hwy 9, to east entrance of Mount Carmel Tunnel, directly below the East Temple Saddle. Parking area on south side, and TH across street, on north side of road. Note you cannot make a left turn into the parking lot if traveling from the east, BUT there is parking along the road about a quarter mile BEFORE you reach the parking lot. This hike is one of Zion's highlights, don't miss it!
Lost of fun with friends
This is an easy trail and we'll worth the effort. The canyon overlook is best viewed at sunrise. There are some neat rock formations and a large alcove along the way. Keep your eyes open for Bighorn. Sheep.
Amazingly this trail has only been around since 1993...it would seem much longer. It's a must on a trip to Zion. It is short and rather easy with little elevation gain, almost all on the climb up from the trailhead by the ranger station at the east end of the tunnel. There are many fantastic views on the hike through Pine Creek Canyon, but that is just the prelude to the amazing view from the cliff overlook above the Great Arch. It is best to go early. The view is better with the sun rising behind you...and the parking spaces in the small lot and along Zion-Mount Carmel Highway go fast. This trail gives you a wonderful way to see Zion Canyon from a special vantage point without having a longer hike like Angels Landing or Observation Point.
my favorite at Zion-which is saying lots!
This was a very enjoyable hike. Fun terrain and great views.
Adrian R.
Kristy D.
Very pretty hike. Easier than it indicates and short. Lots of sheep. Keep driving past and go through the tunnels. It's a really pretty drive too.
A great Zion national starter hike!
Nice short trail with a great view.
Tony S.
Surprisingly fun trail, packs a punch for being shorter trail, definitely would try to fit it in!!! Great view at the end


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By Oromisism
Hi guys,
i just done Elisande on Heroic and i am not really satisfied with my dmg overall, so i wanna ask if someone could take a look over my logs and give me some advices. Thank you :)
logs: https://www.warcraftlogs.com/rankings/character/11194942/latest/
armory: http://eu.battle.net/wow/de/character/malorne/Jybril/simple
By Hindrigan
I just can't find the answer. Why are elemental shamans who take ascendance as their final talent not supposed to use earth shock during ascendance? earth shock does 920% spell power. lava burst does 275%. If you overload with lava burst you do an additional 206% totaling 481% spell power. if you have 25% crit during ascendance lava burst is now 343% spell power and the overload is 257% equaling a total of 600% spell power. you are missing out on a instant cast spell for 320% additional spell power worth of damage; and quite often times twice during ascendance. that's 640% spell power which is more than a lava burst cast during ascendance with 25% crit.
I currently have 18% crit chance and during ascendance I'm critting lava burst at 434k (not extremely well geared I know, but the ratio is still present). earth shock at 100 maelstrom non crit is 400k. If you don't crit with earth shock you lose very little damage. However, if you crit with earth shock you do easily over 1million damage (several lava burst crits worth) I really don't see a down side to using earth shock during ascendance other than 2-4 seconds off of fire elemental due to elementalist in your artifact tree.
By all means show me that I'm being silly. Please. Thanks all
By Hindrigan
Has anyone else been doing more damage with aftershock than with ancestral swiftness (lvl 60 tier talents)? the big thing I've been noticing is how many more earth shocks I'm getting off. Other things are that I don't ever have to worry about how i'm going to set up my maelstrom for full length flame shocks and icefury/frost shock casts. Also, lower damage decrease while moving due to more maelstrom. I'm 865 and I'm doing 20-28k more dmg with aftershock. Your thoughts
By V1R4G3
The updated Icefury build suggests that Totem Mastery is taken. However, nowhere in the priority whatsoever is it used. It is, however, used in the Ascendance build.
That being said, why would you pass on two talents of which you will actually include in your priority to take a talent for an ability you will not? Or is there any error in the priority? Is it worth casting? And where at in the priority?
Thank you.
By denial
Hi all,
i started again since WOTLK to play again my shaman , i leveled up as an elemental since i was always played elemental in the past.
I tested the enchanement a bit , and i like him BUT i dont have in mind to raid except LFR ofc and some heroic dungeons and of course WQ's and grind.
So i am thinking which spec has better survivability i cannot decide , some times ele doing better some times enha going faster vice versa :/
I know that as a casual player now i have to play what is more fun for me BUT with the artifact AP to the weapons ( i have both to lvl 13 but now the AP is going bigger) its not so easy so i have to decide at least which spec to level up the weapon first so an opinion could help me decide.
All i need is fast grind,good dps in dungeons and easy playing with good survivability .
Thank you all for your replies :)


text: Hi M8s, I've inherited a Canon MV530i camcorder but not a manual, cable to transfer to Computer or Software. I've looked on the net for the above but the only site I've found wants stupid amounts of money for the manual and cable. Any ideas where I can download the manual and what cable I need to connect the camcorder, I presume to the USB port and a site for any software I need. Many thanks, Dave


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text: The Leonard Lopate Show Edit this Published by The Leonard Lopate Show Michael Pollan on Leonard's 25th Anniversary at WNYC Listen 1 min Queue Download this audio Want to embed this player? Use the code below. More info. <iframe frameborder="0" scrolling="no" height="130" width="100%" src="https://www.wnyc.org/widgets/ondemand_player/wnyc/#file=/audio/json/60150/&share=1"></iframe> Share on Facebook Share on Twitter Email a Friend Author Michael Pollan talks about his favorite thing about sitting down for an interview with Leonard, and his favorite moment on the show.


text: Seller: sander_i.ua (10) 100%, Location: Kyiv, Kyivska oblast, Ships to: Americas, Europe, JP, AU, Item: 262702882634 Ancient Bronze Viking Pendant Crosses . Kievan Rus. 10-13 century AD. Material : bronze and lead (?)Approximately : 1 inch each. 1 cross is broken. Look pictures. Found with metaldetector. PAYMENT -- I accept payment through PayPal ONLY. SHIPPING -- I ship within 2 business days after the payment cleared and it usually takes 10~21 working days for international delivery.-- Item will be shipped out by economy international post with tracking. FEEDBACKYou receive the product, please leave a feedback for me. Your feedback is always important. Please feel free to contact me before leaving a negative feedback. If there is a problem, I will help you solve it. Best regards! Condition: Restored. Sell "as is". Original., Material: Bronze, Provenance: Ownership History Not Available


text: I have received a Trial Affidvait in preparation for our Federal Circuit Court hearing coming up. 1. How do I apply for leave to the family court to have some extra time to prepare mine? 2. Ex has included illegible screenshots of our son''s text/ Facebook messages that he has obtained without our son's consent (he is 16 if that matters). Firstly, you can barely read them and second he got them without his permission. Is that legal, if not how do I challenge that? 3. My ex has quoted conversations from 8 years ago. I can't even remember, not sure how he can! Is that legal? 4. I am not sure when it comes to lots of character assassinations/allegations that are clearly not true. Do I respond to the point he has made in his trial affidavit or just stick to my own evidence? ** Any links to documents examples for files preparing for hearing if anyone has any links would be appreciated. Thanks


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ONEOK Partners, L.P. (NYSE:OKS) is trading up 116.26% versus 12-month low of 20.66 and stands -4.96% lower from its 1-year peak of $47.01. The consensus price target (PT) of $43.94 means that the market expects Company shares to increase by -1.3% in the short run. The sell-side target prices range from $39 to $50. In the last month the stock has moved in price 6.66%, with a one year change of 104.01%. The last trading session volume compares with the 572.27K average and market worth floats around 12.72B.
ONEOK Partners, L.P. (NYSE:OKS) gained 0.38% to reach at the trading price of $44.68 as it is set to release its next quarterly earnings report on February 27, 2017. ONEOK Partners, L.P. stock trades in the range of $43.94 to $44.93 before the earnings release. Let's take a closer look at the current earnings forecast, particularly the things traders should pay close attention to. Earnings per share for the recently concluded quarter is expected to come in at $0.65 a share with $2.81B in revenue.
ONEOK Partners, L.P. (OKS) Future Earnings & History
After upcoming fiscal quarter results, all eyes will be on the prospects for the next reporting quarter. Analysts, on average, forecast ONEOK Partners, L.P. to earn $0.61 per share (EPS) on revenue of $2.52B. The EPS consensus range is $0.53-$0.76 on revenue between $2.81B and $2.17B.
While if we look at the Earnings Track Record, ONEOK Partners, L.P. (OKS) managed to surpass quarterly earnings per share estimates in 8 of the trailing twelve fiscal quarters, and has a positive trend with an average surprise of 66%. Last time the company reported, ONEOK Partners, L.P. (OKS) generated $0.59 in earnings per share, beating the consensus estimate of $0.58. Revenues hit $2.36B in the September 2017 quarter, which was above the consensus $2.29B projection. On the other hand, in the June 2017 quarter the company recorded a net $2.13B revenue with earnings per share of $0.54. Wall Street had anticipated $2.04B and $0.54, respectively. For comparison, there was a revenue of $1.77B and EPS of $0.52 in the March 2016 period.
ONEOK Partners, L.P. (NYSE:OKS) Analyst Insights
The buoyancy in the outlook of ONEOK Partners, L.P. (OKS) is getting weaker by the somewhat negative sentiment (2.80 on a 5-point scale) that sell-side analysts have provided concerning it. Brokerage firms on the average advocate the company shares as Hold. Piper Jaffray has been covering shares of OKS, so it is most recent view is worth a look. In a research note issued on Nov 03, 2016, analysts at downgraded the stock to Hold from Buy. Another noteworthy analyst activity was recorded on Oct 13, 2016. Downgraded the stock to Neutral from Overweight.


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|[Hadoop Wiki] Update of "Hbase/SearchSuggestion" by udanax
|Tue, 26 Feb 2008 05:02:40 GMT
Dear Wiki user, You have subscribed to a wiki page or wiki category on "Hadoop Wiki" for change notification. The following page has been changed by udanax: http://wiki.apache.org/hadoop/Hbase/SearchSuggestion The comment on the change is: I just move this to my blog. ------------------------------------------------------------------------------ - === Initial Contributors === + deleted - * [:udanax:Edward Yoon] (R&D center, NHN corp.) - - = Introduction = - == Y!'s Search Assist == - - [http://wiki.apache.org/hadoop-data/attachments/Hbase(2f)SearchSuggestion/attachments/figure2.jpg] - - This is a Google's search suggestion of 'ps2 cheat'. - - [http://wiki.apache.org/hadoop-data/attachments/Hbase(2f)SearchSuggestion/attachments/figure1.jpg] - - And This is a Y!'s search suggestion of 'ps2 cheat'. The suggestions can be for detached word of phrase, it means that internally search engine was used for Y! search suggestion. For matching the left-right, it just need an mere word lexicon of left-to-right and lexicon of right-to-left. But, For matching the detached word of phrase, it requires accumulating two different results of the lexicon and posting file and that's why, I say search engine was used for Y! search suggestion. - - In this page, the data modeling and On-line servicing of a search suggestion on a Hbase without development complexity is proposed. - - == Download == - - * http://www.hadoop.co.kr -
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The Conductive Thermal Control Material Systems for Space Applications
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National Aeronautics and Space Administration
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Applied Material Systems Engineering, Inc.(AMSENG)
IL, Schaumburg, IL, 60194-3884
Hubzone Owned:
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Principal Investigator
Name: Mukund Deshpande
Title: Principal Investigator
Phone: (630) 372-9650
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Research Institution
Name: Stub
AbstractThis proposal is submitted to develop and demonstrate the feasibility of processing the space environment stable, multifunctional thermal control material system (TCMS) that can be applied to space hardware and can enables the hardware to carry higher leakage current through engineering the high electrical conductivity. An innovative space environmental stable TCMS is suggested through research & development work for the multifunctional, low ( & #945;S/ & #949;T) material systems that can meet these aggressive goals in cost effective, reliable manner. The suggested efforts emphasize developments in two material science areas: the first one considers the development of born nitride nano structure that includes nanotubes and nano mesh (BNNT-BNNMTM) and the second area proposes the synthesis and processing of various homologous compounds of Zinco-Indates that are recently identified as the high conductivity compounds with high refractive index. The material system that integrates these two technologies can allow higher leakage currents that may also help to defend against the natural solar storm events. The suggested TCMS have been derived from the available mathematical models for space craft charging that pay attention to the individual charge dissipation mechanisms and the molecular dynamics of the material systems as well as its thermodynamics. Thus the envisioned derived material systems can provide the needed reliable TCMS in typical space environments in (LEO), (GEO) & beyond. The reliability goal for the multifunctional conductive TCMS is to have a design life of > 10 years in LEO and > 15 years in GEO, and we anticipate the developments to mature by end of phase II ready for the hardware demonstration.
* information listed above is at the time of submission.
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Our 2017 Class Schedule and Calendar is complete. Please go to Classes or Dates.Our newsletter # 1 2017 BONSAI NO SATORI is ready. Please click below.
Please call us if you need boarding, winter care and maintenance for your temperate bonsai for the winter or while you travel.
Click below on this page ABOUT US to enlarge photos of our recent trip to China.HOLLAND Flowering the world MARCH 11 - 19, 2017 Visit the exhibition of the Rosade Bonsai Studio exhibit at the Philadelphia Flower Show
Get started on your artistic education with bonsai classes from Rosade Bonsai. You'll be learning from an instructor with more than a half century of experience.
Get a better idea of what can be done with bonsai trees with our gallery of images. We have a wide range of bonsai on display at our studio for both viewing and for sale.
Our newsletter, Bonsai No Satori, is available on the website and by email with updated information on new class dates and events.
Learn about the fascinating art of bonsai trees at Rosade Bonsai in New Hope, Pennsylvania. We offer bonsai classes, maintenance, workshops, and boarding. Owners Chase and Solita Rosado have studied, taught and lectured all over the world, spreading the knowledge of an appreciation for bonsai to five continents. We teach novices continuation of bonsai, boarding, indoor and outdoor bonsai, growing, and workshops at the studio for students wanting to start new projects. Come see the Rosade Bonsai Studio Exhibit at the 2016 Philadelphia Flower Show. Chase Rosade started the business in 1970 when he returned from studying in Japan. He continues to educate, demonstrate, lecture, and create bonsai. His standard for excellence in bonsai has become his trademark. Solita, an artist in her own right, shares the day to day activities of Rosade Bonsai Studio. She adds a new and knowledgeable dimension with her involvement in the world bonsai community.
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Following up on our letter No. AE/154/XII-16/MP/aps dated December 22, 2016, regarding 2016 Dividend Interim Payment Schedule and Procedure, we inform the currency conversion rate of Interim Dividend Payment for Fiscal Year 2016, which refers to Bank… read more
Herewith announced that on December 20, 2016, the Board of Directors and the Board of Commissioners of PT Adaro Energy Tbk ("the Company") have decided and approved to distribute an Interim Dividend of US$60,773,327.8 for 31,985,962,000 shares or… read more
PT Adaro Energy Tbk will hold an Annual Public Expose FY2016 on: Date: Tuesday, August 2, 2016 Place: PT Bursa Efek Indonesia Gedung BEI, Tower II, Lantai 1 Jl. Jend. read more
PT Bhimasena Power Indonesia, a company formed by a consortium of PT Adaro Power, a wholly owned subsidiary of PT Adaro Energy Tbk , (34%), Electric Power Development Co., Ltd. (34%) and Itochu Corporation (32%), has reached a financial close for t… read more
PT Alam Tri Abadi, Coaltrade Services International Pte Ltd (both are subsidiaries of PT Adaro Energy Tbk), and BHP Minerals Holdings Pty. Ltd. and BHP Minerals Asia Pacific Pty. Ltd. have signed Share Sale Agreement with the purpose to purchase and to… read more
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text: We're sorry, Apples And Pears Hand Crafted Paper Art is no longer available Why not try one of these instead? Personalised Family Word Art Print by Cherry Pete £79$135.57€94.68$101.23 free UK delivery Personalised Chalkboard Party Backdrop by modo creative £85$145.87€101.87$108.91 Personalised Golden Anniversary Word Art by Cherry Pete £75$128.71€89.88$96.10 free UK delivery Personalised 40th Birthday Word Art Print by Cherry Pete £75$128.71€89.88$96.10 free UK delivery Pinch to zoom Apples And Pears Hand Crafted Paper Art by Illustries £99$169.90€118.65$126.85 This item is no longer available Favourite Favourite View your favourites design optiondesign option (required)Without hand-printed nameWith hand-printed namedesign option (required)Without hand-printed nameWith hand-printed namedesign option (required)Without hand-printed nameWith hand-printed namedesign option (required)Without hand-printed nameWith hand-printed name we're sorry we're sorry, This item is no longer available buy a gift voucher related categories by Illustries Location: Worcestershire, GB read seller's profile see seller's complete range more items from this seller Hand Crafted Butterfly Picture by Illustries £95$163.03€113.85$121.73 Hedgerow Laser Cut Wall Art by Illustries £130$223.10€155.80$166.58 Wedding Planner Limited Edition In Blush A... by Illustries £24.95$42.81€29.90$31.97 Wedding Planner by Illustries £24.95$42.81€29.90$31.97 Baby Journal And Record Book by Illustries £24.95$42.81€29.90$31.97 'Be Our Guest' Wedding Guest Book by Illustries £19.95$34.23€23.91$25.56 view all you may also like PRODUCT DETAILS DELIVERY RETURNS Made in Britain ask seller a question save for later NEW to our collection our cute 'Apples & Pears' piece is just that, apples & pears precision cut, hand arranged and framed. Silhouetted shapes of apples and pears cut from crisp, 270gsm smooth white card overlaid onto shades of fresh greens. Signed in pencil by the artist in the bottom right-hand corner. Framed in a pure white wood box frame. This piece can come just signed or with it's cute name hand stamped on the piece (see images). dimensions: Overall approx size standard white frame: Height 34cm, width 25cm, depth 3cm. Made to order and delivered in 10 days product code: 173435 This product is dispatched to you by Illustries. You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Illustries's return policy Please see notonthehighstreet.com's returns policy.


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Mini Mosquito Repeller (Blue)
The mini mosquito repeller works to protect you while you are fishing, camping, hiking, jogging, on the golf course, or just at ease on your patio or porch.
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3807 Cascade Sky Drive,Arlington TX, 76005
Sold Price
3 beds , 2 Full/1 Half baths
1,974 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Worldwide, REALTORS
(817) 379-3111
Last Updated: 2/25/2017 11:37 PM
Description for 3807 Cascade Sky Drive Arlington, TX 76005
Beautiful 3- 2.5 custom Townhome over $30,000 worth of upgrades HARDWOOD, Granite, Crown Molding throughout with a tall office area. Open concept clean and beautiful in Viridian Village, pools, lakes, Viridian elementary school, miles of nature trails.
Listing Information
Viridian Village 1a2
Slab Foundation
City, Separate Meters
City Sewer
Cable TV
School Information
Room Information
Interior Features
Gas Range/Cooktop, Dishwasher, Disposal, Oven Gas, Carbon Monoxide Detector
Ceramic Tile, Carpet, Wood
Central Air, Ceiling Fan(s)
Alarm-Burglar, Alarm -Smoke/Fire, Monitor System,
Decorator Lights, Internet Connection, Vaulted, Water Purifier, Window Coverings, Fire Sprinklers
Exterior / Lot Features
2 Garage Spaces, 2 Parking Spaces,
Sprinkler System
Community Pool
Less Than .5 Acre (not Zero)
Garden, Exterior Lighting, Security Lighting, Lake Front, Asphalt, Greenbelt, Wooded
Community Features
Community Pool
Financial Considerations
Inside AccessTM
Current market conditions for 3807 Cascade Sky Drive
Active Market Trends
Source:MLS DATA
Median list price$239,500
Days on market64
Properties for sale492
Sold Market Trends
Source:MLS DATA
Median sold price
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Sales to list price
Not enough information to display market trend data at this time
Properties sold948
Median sq ft price$-1
Arrows indicate 90 day trend
Listing Price History for 3807 Cascade Sky Drive
Arlington Real Estate
Arlington is located in Texas. Arlington, Texas 76005 has a population of 367,154.
The median household income in Arlington, Texas 76005 is $53,341. The median household income for the surrounding county is $56,859 compared to the national median of $53,046. The median age of people living in Arlington 76005 is 31.9 years.
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When Google+ launched, many were disappointed to discover that Google didn't offer an option similar to Facebook or Twitter that allows you to socially share content from an external website. An SEO has come up with some helpful code to fix that.
SEO Alex Moss, who develops WordPress plugins, didn't understand why there wasn't an official WordPress plugin or code allowing people to share a URL to Google+ from outside of Google+.
"…As an SEO I'd want to make sure this was available immediately or at least used the +1 button somehow to add functionality to share the +1′d URL within Google+ for all/your circles to see," Moss wrote in a guest post on State of Search.
Moss has modified the Google +1 button and created gray and blue "share" buttons. To make the feature work, Moss modified the share URL from the Google+ mobile site.
For step-by-step instructions on how to implement the new feature to your website or to add it to a WordPress theme, check out the full post here.
Related reading
Brand TLDs vs .com: why the world's biggest brands are making the switch to their own web extension
New Top-Level Domains (TLDs) have become more popular in the last couple of years, so here's everything you need to know about them.
Which Google algorithm changes impacted marketers most in 2016 – and what can we expect from 2017?
Between the long-awaited rollout of Penguin 4.0, a strengthening of Google's mobile-friendly ranking signal and the 'Possum' algorithm update impacting local search, 2016 was an interesting year for Google algorithm changes - and 2017 promises to be just as eventful.
10 online marketing strategies to make you a unicorn [infographic]
Everyone who knows me knows I'm obsessed with unicorns – not just the magical beasts you'll often find hanging out near rainbows but marketing unicorns.
What exactly is a marketing cloud, and do you need one?
The term 'marketing cloud' has gained significant traction in the last few years as major software companies have sought to monetise the growing importance of technology for marketing teams.


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Rhodes Custom Pools Inc
pool repair, Leak Repair, Water Leak
Repair services we offer include: structural crack repair, plaster repair, rust spot removal, drain cover replacement, waterproofing issues, movement issues, tile, coping, decking, plumbing, electrical, equipment, automated control systems, lighting, energy efficiency upgrades, leak detection and repair, and skimmer replacements.
Our mission is to deliver the best quality, service, and materials at a fair price, and to exceed our customers expectations on every project.
Our service area is The Ozarks Of Missouri ( Southwest Missouri ).
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The Ensembl () project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from Ensembl has increased from 15 to 33, with the addition of sites for the mammalian genomes of elephant, rabbit, armadillo, tenrec, platypus, pig, cat, bush baby, common shrew, microbat and european hedgehog; the fish genomes of stickleback and medaka and the second example of the genomes of the sea squirt (Ciona savignyi) and the mosquito (Aedes aegypti). Some of the major features added during the year include the first complete gene sets for genomes with low-sequence coverage, the introduction of new strain variation data and the introduction of new orthology/paralog annotations based on gene trees.
The genome sequence of an organism provides a natural index for organizing and understanding biological data. Ensembl is a software system to store, analyze, use and display genomic information. Ensembl's primary focus is around providing gene annotation and comparative genome integration for chordate genomes, the vast majority of which are vertebrates. Ensembl concentrates particularly on mammalian genomes having developed initially around the human genome sequence. Some major distinguishing features of the project compared to other major sites providing access to these genomes at UCSC (1) and NCBI (2) are that Ensembl creates a gene set, using an automatic gene build pipeline, for each species for which no manually curated gene set exists and that Ensembl makes all its data and software source code available to all users to encourage its reuse and programatic access. As discussed below, for the relatively mature vertebrate genomes of human and mouse where there are active efforts to curate gene structures by the Havana group through Vega (3) the RefSeq group (2) and UniProt (4) Ensembl is actively collaborating with these groups to converge on the reference gene set.
The genomes of 28 chordates are currently available through Ensembl, from mammals such as human and mouse through to the 'primitive' chordates Ciona intestinalis and Ciona savignyi. Ensembl sites for the genomes of three key eukaryote model organisms, yeast (Saccharomyces cerevisiae), fruitfly (Drosophila melanogaster) and nematode (Caenorhabditis elegans), are provided to allow integration, primarily around predicted ortholog/paralog relationships, between these organisms and chordates within a common database environment. For these organisms, no automatic gene build is performed and instead gene annotation is imported from their respective model organism databases. Finally, a number of insect genomes are also available through Ensembl due to Ensembl's participation in the Vectorbase consortium (). Vectorbase is an NIH–NIAID Bioinformatics Resource Center for Invertebrate Vectors of Human Pathogens and is using the Ensembl platform to present key vector genomes. It is likely that in the future these vector genomes will only be available on the Vectorbase site, though Vectorbase will continue to use Ensembl software. This year's increase in the number of genomes provided by Ensembl is the largest so far (Figure 1). More than half the genomes in Ensembl are mammalian. In keeping with the focus on chordates, Ensembl has this year stopped providing an Ensembl site for the honeybee (Apis mellifera) genome, while being involved in the initial analysis and producing an initial geneset (5), just as the previous year it stopped providing a site for the second nematode Caenorhabditis briggsae. This is because it recognizes that access to these genomes is being provided by the dedicated Beebase () and Wormbase (6) model organism databases. In both cases the old Ensembl databases for these genomes remain accessible via Ensembl archive sites.
Ensembl provides a variety of ways to access these data to suit different audiences and types of use. The majority of researchers using Ensembl use the website () and can rapidly locate individual items of interest either by entering keywords or from the built-in sequence similarity search interface. For cases where researchers are working with sets of items, such as a particular class of genes, Ensembl provides data mining tools via the BioMart system (7). For bioinformaticians Ensembl provides access to all the data behind the Ensembl website both as downloadable datasets and by allowing programatic access to databases hosted on the Ensembl site (). The later is growing in popularity as complete database dumps become large to download. Increasingly bioinformaticians are carrying out their own custom data analysis by accessing the databases remotely via the Perl language application programing interfaces (APIs) that Ensembl provides. Extensive documentation and tutorials are provided to help researchers get started programing using the APIs as well as describing the database schemas (). Ensembl runs courses and training around the world, has a full-time helpdesk and online tutorial materials (). Over the year courses have been held in the following countries: UK (16×), Austria (2×), Belgium (4×), Finland (2×), France (2×), Germany (2×), Hungary, Italy (6×), Spain (4×), USA (3×), Brazil (2×), South Africa (2×), Australia (2×) and Singapore. There are many practical details concerning data processing algorithms developed and used by Ensembl and the overall system's design and operation. For detailed descriptions, researchers are referred to the series of papers published in 2004 that describe both technical aspects of the software implementation and the scientific aspects of the genome annotation system (7–16). Whilst the system has evolved considerably since these articles were published, they provide a background to the technical documentation maintained on the Ensembl website and distributed with each software release. As an open data, open source software project Ensembl encourages participation and discussion on development issues mostly via the development email list (send 'subscribe ensembl-dev' to firstname.lastname@example.com to join). We are seeing this email list being increasingly used to exchange advice on API usage.
Ensembl continues to improve both in terms of the analysis of genome information and its usability both via programatic means and for web-based browsers. This paper details only some of the major improvements since the last report (17). For more comprehensive information about new features and data contained in the bi-monthly updates of Ensembl, researchers are also recommended to read the 'what's new' pages accompanying every release () and/or subscribe to the 'announce' email list by sending 'subscribe ensembl-announce' to firstname.lastname@example.com.
Improvements to protein-coding genes
Providing expressed gene sets which are as accurate as possible is one of the major goals in Ensembl. Ensembl gene sets are all based on evidence from alignments of protein and cDNA sequences to genomic sequence. The completeness of each gene set depends on the amount of transcript data, either specific for the genome in question, or evolutionarily close enough to be reliably aligned. Gene set accuracy depends on alignment quality and being able to reconcile evidence, including detecting erroneous data from truncated and chimeric transcripts and identifying pseudogenes. This year's major improvements and changes to the Ensembl gene build systems and strategy cover the following three different situations for gene building: (i) the new class of low-sequence coverage mammalian genomes; (ii) high-coverage genomes which have little organism-specific transcript data; and (iii) the high-quality reference genomes of human and mouse.
New projection build pipeline for low-sequence coverage genomes
Ensembl has this year incorporated the first nine genomes which have been sequenced at low-coverage [2× whole genome shotgun (WGS)]. These are elephant (Loxodonta africana), rabbit (Oryctolagus cuniculus), armadillo (Dasypus novemcinctus), tenrec (Echinops telfairi), cat (Felis catus), bush baby (Otolemur garnettii), common shrew (Sorex araneus), microbat (Myotis Lucifugus) and european hedgehog (Erinaceus europaeus). In total 16 mammals will be sequenced at this coverage as part of the Mammalian Genome Project, funded by the National Institutes of Health (NIH). Currently, automatically generated gene set are provided for the first four of these genomes and gene builds are in progress for the remaining five. The low sequence coverage of these genomes means that all of the normal problems experienced when predicting gene structures in draft genome assemblies (missing sequence, fragmentation, misassemblies, misplacements, small insertions/deletions/substitutions) are exacerbated. In particular, many genes will be represented only partially (or not at all) in the assembly, and many others (particularly those with large genomic extent) will be found in pieces, distributed across more than one scaffold. The standard Ensembl gene build pipeline (11), which relies on aligning expressed transcript sequences onto the genome sequence, is unsuitable as the main approach for annotating such a low-coverage genome.
To address this, a new gene building methodology for low-coverage genomes has been developed that relies on a whole genome alignment (WGA) to an annotated, reference genome. The WGA underlying each annotated gene structure in the reference genome are used to infer 'gene-scaffold' assemblies of scaffolds in the target genome that contain complete gene structures. WGAs are generated in-house using BLASTz (18) with the resulting set of local alignments processed into a form suitable for the above method using the Axt tools (19). The protein-coding transcripts of the reference gene structures are then projected through the WGA onto the implied gene-scaffolds in the target genome. These projections frequently contain small insertions/deletions with respect to the protein-coding transcript of the reference gene structure. In some cases this raw projection would result in a frame shift in the translation. In the vast majority of such cases this apparent frame shift is most likely the result of a sequence/assembly error in the target genome, resulting from the low sequence coverage. To correct for these apparent errors, the gene build introduces an artificial intron, 1 or 2 bp long, into the predicted gene structure to correct the frame shift at each point where one is introduced. In this way the reading frame of the predicted transcripts are preserved. We refer to these introns as 'frame-shift introns'. When the WGA implies that the sequence contains an internal exon missing from the assembly, and the location is consistent with an intra- or inter-scaffold gap, the exon is placed on the gap sequence. This results in a run of X's of the correct length in the translation. An example of this situation in the elephant (L.africana) genome is shown in Figure 2.
This strategy has been developed and piloted on the initial 3× coverage WGS assembly of the cow (Bos taurus) genome. The current cow assembly is 6× coverage and its gene set has been generated using the standard Ensembl pipeline. A new higher quality 7.1× coverage cow assembly, that incorporates sequence data from BAC libraries, has just been released. When the gene build on this assembly is complete it will be possible to carry out a more detailed assessment of the quality and value of gene builds on low-coverage genomes by comparison to standard gene builds on high-quality assemblies. In the mean time some statistics for exon coverage for both the gene builds on the 3× and 2× assemblies are shown in Table 1. For all of these gene builds the human genome has been used as the reference, making side by side comparison possible. Since all these genomes are mammals, it is anticipated that the vast majority of human coding exons should be found in each. The number of exons annotated therefore gives an idea of the quality of gene builds possible given the genome assembly quality. The first two columns of Table 1 show the percentage of base pairs of human exons that can be aligned to the sequence of the target genome by the WGA BLASTz step and the percentage completely missed. These values are a few percentage points less than the theoretical expected percentage coverage for 2× and 3× WGS sequencing of 88% and 95%, respectively, but broadly in line with expectations (20). The last two columns show the equivalent figures for the final gene set after it has been filtered as a result of the gene build process and are significantly lower. In the current gene build process, after raw alignments are chained into gene-scaffolds and the best-in-genome match found, predicted gene structures are removed if >50% of the original exons are missing. These criteria are adopted as in our view where such partial genes are built they contain an unacceptable likelihood of error and are better discarded. Most likely, many of these partial genes result from assembly artifacts; however, this will be better understood after the cow gene set comparisons are carried out. In the mean time it is worth noting the significant difference between the final exon coverage for the initial 3× cow genome and the other four 2× genomes. It appears that dropping from 3× to 2× sequence coverage roughly doubles the fraction of exons missing from resulting gene sets when the filtering we believe necessary to achieve acceptable gene set quality is applied.
|Raw unfiltered
|Filtered chained (final gene set)
|Base pair covered (%)
|Exons missed (%)
|Base pair covered (%)
|Exons missed (%)
|Cow (3×)
|Raw unfiltered
|Filtered chained (final gene set)
|Base pair covered (%)
|Exons missed (%)
|Base pair covered (%)
|Exons missed (%)
|Cow (3×)
This table shows fraction of base pairs of human Ensembl gene set exons covered by raw alignments to WGS scaffolds (first column) and in the filtered, chained gene-scaffolds presented as the final gene set (third column). Fraction of exons completely missed in each case is also shown (second and fourth column, respectively). All genomes are 2× WGS assemblies, except for cow which is 3× (see text).
The code developed for the projection build has also been applied in the gene build for the new chimpanzee (Pan troglodytes) genome assembly, which has greatly improved the gene set. For chimpanzee the gene-scaffold generation step is skipped as the assembly is high coverage.
Improved pipeline for genomes that are evolutionarily distant from main sources of transcript data
The completeness of each gene set depends on the quantity of transcript data either specific for the genome in question, or evolutionarily close enough to be reliably aligned. Although there are a number of large chordate genomes with little organism-specific transcript data, most are mammals and so evolutionarily close to the huge amounts of transcript data from human and mouse. The current major exceptions are chicken (Gallus gallus) and opossum (Monodelphis domestica). Two gene sets have been produced on the chicken genome assembly and been made available though the Ensembl website. For both gene builds the standard Ensembl gene build pipeline was used; however, for the most recent gene build (December 2005) the pipeline was significantly customized to improve gene set quality. Investigations showed that mapping distantly related cDNAs and ESTs onto the chicken genome using the standard pipeline was creating very extended gene structures, incorrectly linking transcripts of some adjacent genes. Gene building on vertebrate sized genomes is very expensive, so the pipeline contains optimizations to reduce the CPU cost. One such strategy is the creation of 'mini' sequences (11) which remove regions thought to be intronic from the final alignment step. In the case of chicken, because of the low similarity of transcripts from other organisms being mapped to the genome sequence, this step was removing some exons and causing gene artefacts in some regions. Removing the mini sequence step and optimizing other parameters resulted in a greatly improved gene set. This process was in part developed in parallel for the opossum genome. Although opossum is nearer to other mammals than chicken, adopting this approach led to similar quality improvements. The downside is a ∼5-fold increase in the CPU cost of the gene build; however, this has been at least partly offset by optimizations to the genewise program (9) itself which is used for this final alignment step.
Converging to the reference gene set for the high-quality reference genomes of human and mouse
Analysis showing the progressive and significant improvement in the quality of human and mouse gene sets generated by the Ensembl system were presented in past year's report (17). More recently a blind test assessment of gene set quality took place under the ENCODE project (21). The EGASP gene prediction competition (22) was held to compare a variety of automatic gene prediction methods with a curated and experimentally validated human gene set generated by the Sanger Havana group (3) as part of the Gencode consortium (23). The results confirmed the high accuracy of Ensembl gene predictions, with Ensembl ranked as the best or close to the best over a variety of different evaluation criteria. However, the best predicted transcript for each gene still differed to the annotated Gencode reference in 30% of cases. When all annotated alternative transcripts were considered, transcript accuracy was only 40–50%. Even allowing for errors in the Gencode set, this is a significant gap. For further details of the evaluation the reader is referred to the special issue of genome biology devoted to evaluation of the EGASP experiment, especially (22). While the EGASP evaluation will lead to some further improvements to the Ensembl gene build system for human and mouse, we recognize that there are likely to be limits on how much more the accuracy of automatic methods on these very high-quality genomes can be improved. Human and mouse already have extensive species-specific experimental data, and there are diminishing returns from each increase in the complexity of the gene build logic to handle remaining hard classes of gene, such as dense clusters of duplicated genes.
For the human genome, Ensembl and Havana have for some time been collaborating as part of the CCDS consortium which includes the RefSeq group at NCBI (2) and the UCSC genome group (1). CCDS is a stable set of protein-coding gene structures for which all consortium members agree on to the base pair. The initial CCDS set contained 13 142 loci which corresponded to ∼60% of the 22 000 protein-coding loci annotated in Ensembl being accepted (for further details and statistics concerning CCDS sets, see ). The CCDS process is being extended to the mouse genome now that the assembly (NCBI build 36) is largely composed of finished sequence. While CCDS only addresses the CDS region of gene structures, the Gencode experience illustrates the value of making greater use of the full Havana curated annotation including UTRs, noncoding transcripts and pseudogenes. As a result the Havana and Ensembl gene build groups are now working towards a single integrated gene set that combines automatic and curated annotation, the first version of which was released in Ensembl 38 (April 2006). In this first iteration 12 000 Havana curated full length protein-coding transcripts were incorporated into Ensembl gene entries directly. Because of the problem of reconciling differences between slightly different annotations that probably represent the same transcript, this initial process led to some transcript duplication. We are working to progressively refine the merging process to address this. The process is providing improvements in both directions. In many cases Havana transcripts are more complete as its possible to set lower alignments thresholds since manual review filters out false positives. However, because it is very slow, manual annotation always risks being out of date, so Ensembl transcripts can also be longer when they have used more recent transcript evidence. Ensembl is also identifying regions where the quality of annotation from the automatic gene build pipeline is low so that they can be prioritized for manual curation by the Havana group. There is still a long way to go in this process as Havana annotation is only available for ∼50% of the human genome and ∼20% of the mouse genome; however, it is hoped that with this system of prioritization it should be possible to more rapidly improve the overall quality of human and mouse gene sets.
IDHistoryView and stable identifier discovery
A key utility of all gene sets, regardless of how they are generated, is stability of identifiers between releases. Ensembl manages to map the vast majority of stable identifiers between gene builds; however, changing assemblies, evidence, algorithms and logic inevitably lead to previously predicted genes being absent from a subsequent release or gene splits and merges events. The Ensembl core schema now fully supports an archive of obsolete transcript entries and a new view IDHistoryView has been introduced to allow the history of an identifier to be viewed. Using this interface it should be possible to discover the fate of any Ensembl gene stable identifier back to Ensembl 1.2 (2001) and see how the sequence of the gene structure has changed (the version of transcript and exon stable identifiers is increased if the sequence of that feature changes). The page contains links to Ensembl archive versions to allow users to view older gene structures as they were previously presented.
Variation resources
In the previous report on the Ensembl project (17), major improvements to handle large scale variation data were described. One component of this was a software infrastructure to efficiently store resequencing data. This year we have exploited this system to take advantage of the extensive collection of mouse DNA sequence reads, including those recently released by Celera, data from dbSNP and resequencing data generated by Perlegen Sciences for the US National Institutes of Environmental Health Sciences (NIEHS). These were processed at the Sanger institute using the well-established SNP calling algorithm ssahaSNP (24) to compute >50 million SNPs from common laboratory Mus musculus strains, which were then merged with dbSNP release 126. The resulting data were incorporated into the Ensembl variation schema and a new transcript-centric display TranscriptSNPView was developed to show this variation in a strain-specific way (25). Figure 3 shows an example of this display. TranscriptSNPView is also available in dog (Canis familiaris) Ensembl to provide access to SNPs determined from 16 different strains as part of the dog sequencing project (26). As well as providing an organized view of these data through a web interface, the underlying data storage structure and variation software API makes it easy for bioinformaticians to write custom programs to analysis these complex data. For example, the API makes it possible to view variation from the point of view of any strain with all necessary coordinate transformation being carried out transparently. With resequencing data being generated at an ever increasing rate we anticipate incorporating strain-specific data for a variety of species in the future. Specifically rat (Rattus norvegicus) and chicken (G.gallus) variation data will be available through TranscriptSNPView before the end of 2006.
Comparative genomics
The major improvement in comparative genomics has been the June 2006 release switch of the ortholog/paralog prediction pipeline to one based on protein tree calculations from one based on best reciprocal similarity relationships. This is a major change and has required a completely new pipeline, schema, API and display. In the new pipeline maximum-likelihood phylogenetic unrooted gene trees are built using the algorithm PHYML (27) from multiple protein sequence alignments generated using MUSCLE (28) for each gene family containing sequences from all species. Gene families are generated by calculating best reciprocal relationships between translations of all genes followed by single linkage clustering. Finally each gene tree is reconciled with the species tree using the RAL algorithm (29) to call duplication events on internal nodes and to root the tree. The advantage of a gene tree based pipeline is that it is able to identify complex one-to-many and many-to-many relationships between genes resulting from ancient duplication events, unlike best reciprocal methods. The new structure of orthology/paralogy relationships permeate the entire Ensembl site; however, the biggest visual change is the new GeneTreeView display as shown in Figure 4. Predicted gene trees of course suffer issues of the prediction algorithm's parameters not being ideal for all cases and of bad sequence alignments introducing errors, just as does automatic gene annotation: in a proportion of cases the predicted tree will be worse than could be obtained by manual curation. As a result a similar relationship between Ensembl automation and curation is developing for gene trees as for gene sets. Ensembl has started to collaborate with the TreeFam project (30), a curated resource of gene trees, and is currently investigating ways to integrate available curated data into the automatic pipeline.
One of the hidden consequences of switching to this more robust predictive model is the ability to use the more reliable implied functional relationships between genes to propagate functional labeling between them. Previously Ensembl genes were described as 'Known' if there was some known functional description attached to supporting organism-specific transcription sequence (such as from UniProt). If the only annotated supporting evidence was from another organism, the gene would be labeled as 'Novel'. From the February 2006 release, a third category of genes was introduced called 'Known by projection'. For these genes, a functional description has been projected from GO terms via the orthology mapping. Although these are predictions, we are confident that the annotation is sufficiently accurate to be very useful.
Web usability and web service integration
Following the major redesign of the website reported past year (17), this has been a year of consolidation for the website, adding completely new views, such as TranscriptSNPView, GeneTreeView and IDHistoryView and working on backend infrastructure that will allow new functionality, such as users logins to be added over the coming year.
There are a number of areas which Ensembl is anticipating over the coming year. The increase in the number of 2× genomes will require continuous development of both gene building and comparative genomics pipelines. In comparative genomics we are also concentrating on providing other clade-specific multiple alignments, starting with the telosts. We will be collaborating with the TreeFam group (30) to provide better gene level comparative genomics across the genomes we handle. We envisage a steady growth of whole genome assays of DNA-binding proteins using techniques such as Chromatin immunoprecipitation on DNA microarrays (ChIP/chip) and other functional studies of genome sequence over the next year. We see ArrayExpress (31) as a natural archive of the experimental results such as ChIP/chip, but Ensembl as the display and integration engine; our goal is to move beyond just the display of the ChIP/chip results towards providing a 'Regulatory Build' integrating appropriate information. Finally we foresee growth in the variation data both in human and in other species, in particular resequencing data. We hope to integrate more resequencing information currently available in the trace archive (, ) with many of the species in Ensembl and present it in a friendly manner.
The Ensembl project is principally funded by the Wellcome Trust with additional funding from EMBL, NIH–NIAID and BBSRC. We are grateful to Gudmundur Arni Thorisson, to users of our website and to the developers on our mailing lists for much useful feedback and discussion. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.
Conflict of interest statement. None declared.


text:
Lily was just your typical 16-year-old not-so-innocent girl until
her mother passed away and left her with the only person she could consider a father figure in her life, her brother Luke. She had never pinned him as the fatherly type, though he did act as the protective man in her life throughout the years when their own biological father had left them to fend for themselves.
With Luke just graduated from college at the age of 25 and having to act as a legal guardian for his hormonal younger sister, will he be able to create a stable home for them both and keep her from being taken into custody of the government?
Or will things spiral out of control when a hazy drunken night sends Lily into even more trouble than she can handle?
(WARNING: This book contains heavy profanity and mature scenes. Agegap, incest (as shown in the title), depression, self-harm and other disturbing features are contained in this book. Read no further if any of the parts bother you.)
akagorgeous Jan 08
If Calum isn't in the story now that must mean he'll be in the story later on ;)
suprrgurl Nov 30, 2016
This relationship would only be legal if Luke was also under the age of eighteen. Yes, the legal age of consent is sixteen, but if Lily is sixteen, and Luke is twenty five, it would be considered pedophilia because she is under the legal age of eighteen, and is still considered a child.
Daddy-Abel Dec 09, 2016
I'm very supportive of age gaps because I have a age gap kink myself. And I strangely have a liking for incest fics


text:
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We're at it again! Another first from SM Jaleel & Co Ltd. #TeamSMJ #ChubbySoftDrinks #Global https://t.co/lUdmpOahFb https://t.co/jrZMkA8xeM


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Originally posted on Giants Football Blog | Last updated 11/2/11
Some quick facts, figures and things to watch for in NFL Week 9… Quick to Rebound: Entering Week 9, five teams – Buffalo (5-2), Carolina (2-6), Cincinnati (5-2), Detroit (6-2) and San Francisco (6-1) – have already equaled or surpassed their win totals of last year. The Houston Texans (5-3) can accomplish the feat this week when they host the Cleveland Browns. If Houston earns a victory, it will mark the sixth team this season to have equaled or surpassed their previous season's win total through nine weeks, tied for the second-most since 1990. Up and Coming: The Kansas City Chiefs have won four consecutive games after starting the season 0-3. With a win against Miami on Sunday, the Chiefs can become the fifth team to win five consecutive games after starting a season 0-3 since 1970. LONE UNDEFEATED: The defending Super Bowl champion Green Bay Packers are 7-0 – the last remaining undefeated team in the NFL this season. With a victory this Sunday, the Packers would become just the ...
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Private In-Home and Online ASPIRE Tutoring in Inglewood, CA
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"Today I did reading comprehension exercises and math exercises with the girls. We worked on the main idea of the story and the sequence of events. We then worked on some vocabulary exercises. We completed math exercises that we had to work backwards to get the answer. I also helped Student 1 with a homework problem she had. Overall, the girls' reading is improving."
"We continued to work on factoring techniques in preparation for the student's exam on Tuesday. He had a few questions on his review sheet, which we addressed and clarified. He was able to complete his review sheet for algebra with little assistance. For physics, he seems to be doing very well and is confident about his abilities. We will pick back up in January and begin reviewing for his midterms. Over the break, I recommended that he compile all his study material for his midterms."
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text: I had two problems with compiling the latest gtk2hs from http://haskell.org/gtk2hs/gtk2hs-0.9.10.6.tar.gz and the ebuild available there. 1) I had no ebuild for the RDEPEND "dev-haskell/mtl". I couldn't find any mention of it on packages.gentoo.org. Luckily, removing it from the ebuild still allowed me to compile it. 2) Had to add "--disable-split-objs" to the ebuild otherwise it failed with the too many args error. Here's some info from emerge: trinity ~ # emerge --info Portage 2.1.2-r9 (default-linux/amd64/2006.1, gcc-4.1.1, glibc-2.4-r4, 18.104.22.168 x86_64) ================================================================= System uname: 126.96.36.199 x86_64 Dual Core AMD Opteron(tm) Processor 270 Gentoo Base System release 1.12.9 Timestamp of tree: Fri, 16 Feb 2007 22:59:01 +0000 dev-java/java-config: 1.3.7, 2.0.31-r3 dev-lang/python: 2.4.3-r4 dev-python/pycrypto: 2.0.1-r5 sys-apps/sandbox: 1.2.17 sys-devel/autoconf: 2.13, 2.61 sys-devel/automake: 1.4_p6, 1.5, 1.6.3, 1.7.9-r1, 1.8.5-r3, 1.9.6-r2, 1.10 sys-devel/binutils: 2.16.1-r3 sys-devel/gcc-config: 1.3.14 sys-devel/libtool: 1.5.22 virtual/os-headers: 2.6.17-r1 ACCEPT_KEYWORDS="amd64" AUTOCLEAN="yes" CBUILD="x86_64-pc-linux-gnu" CFLAGS="-march=opteron -O2 -pipe" CHOST="x86_64-pc-linux-gnu" Cheers, Adam On 2/19/07, Duncan Coutts <duncan.coutts@...> wrote: > Is there anything left to do before the final release? I think we're > done. Have we missed anything? > > In the mean time I've been hacking on c2hs. I want us to move to using > the mainline c2hs (and then Cabal). I've been beefing up the C parser > (it can now parse the whole Linux kernel). I also want to have it deal > sensibly with the case that lots of .chs files use the same single > header file. However I think we should also move to using the mainline > {# call #} style - but that's probably best left as a discussion for > another day... :-) > > Duncan > > > ------------------------------------------------------------------------- > Take Surveys. Earn Cash. Influence the Future of IT > Join SourceForge.net's Techsay panel and you'll get the chance to share your > opinions on IT & business topics through brief surveys-and earn cash > http://www.techsay.com/default.php?page=join.php&p=sourceforge&CID=DEVDEV > _______________________________________________ > Gtk2hs-devel mailing list > Gtk2hs-devel@... > https://lists.sourceforge.net/lists/listinfo/gtk2hs-devel >


text:
The euro was trading higher against the dollar on Monday after data showed the Euro-zone manufacturing sector expanded more-than-expected in August.
EURUSD traded above the key $1.32 level, hitting a session high of $1.3225, off last week's trough of $1.3172.
However against the British pound, euro weakened to a two-month low after strong U.K. manufacturing PMI data which increased at its fastest pace in over two years, lifting expectations that an economic recovery is gathering pace in the third quarter.
EURGBP slid to 84.71 pence, down 50 pips since Friday's close. GBPUSD surged to $1.5592 up 80 pips since Friday's close.
Also propping up sterling is a deal by Vodafone and Verizon Wireless. It is expect4ed that the British company will sell its stake in Verizon Wireless, which could involve bringing over £30 billion of cash back into the U.K.
The yen is weaker across the board today as a result of Japan's Prime Minister's bond stimulus measures to boost the economy. One of these measures includes a sales-tax increase for which he approved backing today. Stimulus measures tend to have a weakening effect on the yen.
USDJPY surged to 99.41, the highest level in a month while EURJPY gained over 1 percent to 131.37 yen.
Looking ahead to the U.S. session, there are no data releases due to markets being closed in the U.S. and Canada. A quiet session is expected.
Meanwhile focus will turn to central bank meeting from the ECB and BOE later this week, as well as the BOJ.Publication source