text:
Frank G.A.,Pa Herzen Moscow Oncology Research Institute |
Andreyeva Yu.Yu.,Pa Herzen Moscow Oncology Research Institute |
Gorelik M.Z.,Primorye Territorial Morbid Anatomy Bureau |
Zavalishina L.E.,Pa Herzen Moscow Oncology Research Institute |
And 4 more authors.
Arkhiv Patologii | Year: 2012
The paper analyzes 10 years' experience in HER2 status testing in breast cancer in Russia. The ASCO/CAP HER2 testing guidelines adaptable to the work of pathologists in Russia are considered. Source
Zasadkevich Yu.M.,Ural Federal University |
Brilliant A.A.,Institute of Medical Cell Technologies |
Sazonov S.V.,Ural Federal University
Arkhiv Patologii | Year: 2015
The review gives data on the structure of cadherin cell adhesion molecules, their role in the body's development and malignant tumor progression. It describes cadherins that are considered to play the most important role in the development of a tumor process: E-, P-, and N-cadherins that belong to type I classical cadhedrins and VE-cadhedrin that does to type II cadherins. Particular emphasis is placed on the signal mechanisms with involvement of cadherins and cadherin-related molecules, which are realized in the body in health and in tumor transformation of cells. Source
The comparison of results of detection of minimal residual disease in peripheral blood and marrow in children of the first year of life with acute lymphoblastic leucosis
Tsaur G.A.,Ural Federal University |
Riger T.O.,Institute of Medical Cell Technologies |
Popov A.M.,Institute of Medical Cell Technologies |
Nasedkina T.V.,Russian Academy of Sciences |
And 6 more authors.
Klinichescheskaya Laboratornaya Diagnostika | Year: 2015
The occurrence of minimal residual disease is an important prognostic/actor under acute lymphoblastic leucosis in children and adults. In overwhelming majority of research studies bone marrow is used to detect minimal residual disease. The comparative characteristic of detection of minimal residual disease in peripheral blood and bone marrow was carried out. The prognostic role of occurrence of minimal residual disease in peripheral blood and bone marrow tinder therapy according protocol MLL-Baby was evaluated The analysis embraced 142 pair samples from 53 patients with acute lymphoblastic leucosis and various displacements of gene MLL younger than 365 days. The minimal residual disease was detected by force of identification of chimeric transcripts using polymerase chain reaction in real-time mode in 7 sequential points of observation established by protocol of therapy. The comparability of results of qualitative detection of minimal residual disease in bone marrow and peripheral blood amounted to 84.5%. At that, in all 22 (15.5%) discordant samples minimal residual disease was detected only in bone marrow. Despite of high level of comparability of results of detection of minimal residual disease in peripheral blood and bone marrow the occurrence of minimal residual disease in peripheral blood at various stages of therapy demonstrated no independent prognostic significance. The established differences had no relationship with sensitivity of method determined by value of absolute expression of gene ABL. Most likely, these differences reflected real distribution of tumor cells. The results of study demonstrated that application of peripheral blood instead of bone marrow for monitoring of minimal residual disease under acute lymphoblastic leucosis in children of first year of life is inappropriate. At the same time, retention of minimal residual disease in TH4 in bone marrow was an independent and prognostic unfavorable factor under therapy of acute lymphoblastic leucosis of children offirstyear of life according protocol MLL-Baby (OO=7.326, confidence interval 2.378-22.565). Source
Drui A.E.,Regional Childrens Hospital No. 1 |
Drui A.E.,Ural Federal University |
Shorikov E.V.,Regional Childrens Hospital No. 1 |
Shorikov E.V.,Institute of Medical Cell Technologies |
And 10 more authors.
Voprosy Onkologii | Year: 2015
Deletion of CDKN2A/pl6 gene located in the 9p21.3 region is common alteration for many types of cancer. It was described in neuroblastoma patients as well, while its prognostic significance is contradictory. The aim was to determine the epidemiology and prognostic impact of 9p deletion in neuroblastoma patients. 9p status was analyzed by MLPA in 100 tumor samples from primary neuroblastoma patients. Prognostic significance was estimated by overall (OS) and event-free survival (EFS) with median of follow-up time 28 months (range 1-166 months). 9p deletion was revealed in 8 (8.0%) patients, in 5 of them localized in 9p21-23 loci and in 3 involved only locus 9p21.3 (CDKN2A/pl6). Stage distribution was as follow: stage 1-2 patients, II-1, III-2, IV-3 and no patients with IVS stage. We didn't find any association of 9p deletion with clinical (stage, histological subtypes, age) or genetic (MYCN amplification (MNA), lp, llq deletions) risk factors. Presence of 9p deletion resulted in dramatic decreasing of survival rates: both EFS and OS were 0.00 vs. 0.60±0.06 and 0.68±0.06 correspondingly, p=0.035, p=0.014). Prognostic significance of this aberration retained in patients with localized neuroblastoma (EFS and OS 0.00 vs. 0.85±0.06 and 0.91±0.05 respectively, p=0.058, p=0.031) as well as in MYCN non-amplified patients (EFS and OS 0.00 vs. 0.68±0.06 and 0.75±0.06, p=0.047, p=0.017). In multivariate analysis of OS performed by stage, age, MNA, lp, 9p deletions and 17q gain as covariates patients with stage IV (p=0.042), MNA (p=0.049) and 9p deletion (p=0.041) had significantly poor survival. Thus 9p deletion involving CDKN2A/pl6 gene demonstrated strongly negative prognostic impact. Significance of this abnormality retains in favorable groups of patients with localized rumor and without MYCN amplification. Source
The prognostic value of the detection of bone marrow lesion in children with neuroblastoma by flow cytometry
Popov A.M.,Ural Federal University |
Shorikov E.V.,Institute of Medical Cell Technologies |
Verzhbitskaya T.Yu.,Institute of Medical Cell Technologies |
Tsaur G.A.,Institute of Medical Cell Technologies |
And 4 more authors.
Voprosy Onkologii | Year: 2015
The purpose of the study was to evaluate the prognostic value of the detection of tumor cells in the bone marrow (BM) in children with neuroblastoma (NB) by flow cytometry. The detection of tumor cells was performed in BM of 51 patients with NB (24 boys and 27 girls) aged from 6 days to 15 years (median - 1 year 3 months). Flow cytometry allowed determining NB cells in BM in a much larger number of cases than cytomorphology (49.0 % and 29.4 % of patients, respectively). Patients, in whom NB cells were not detected in BM by flow cytometry, had significantly better event-free and overall survival rates as well as progression free survival (83, 5 %, 87, 7 % and 86, 8 %, respectively) compared with those in whom immunophenotyping revealed the tumor cells (28, 0 %, 35, 87 % and 34, 3 %, respectively). The prognostic value of the detection of BM lesion by flow cytometry was also confirmed in selected groups of patients with other criteria of stratification. Therefore the detection of tumor cells in BM by flow cytometry could potentially be considered in conjunction with other factors in choosing treatment strategy in patients with NB. Source


text:
"having trouble with my project runway limited edition brother the thing on the side that rest the needle has got really tight please help me"
My kids and I were clueless about how to sew, but with the good instructions and easy operation, we've made some cool stuff. We have barely scratched the surface of what this can do, and I'm looking forward to learning more....
Brother CE5000 Project Runway Edition Sewing Machine (Refurbished)by Brother
- Professional sewing machine is ideal for the designer in you
- CE5000 PRW is a Project Runway Limited Edition computerized and electronic sewing machine
- Sewing machine boasts 50 built-in stitches and 87 stitch functions
- Use the LCD screen to choose decorative, quilting or heirloom stitches to embellish your wardrobe
- Exceptional feed system enables effortless sewing on denim, tweed and other thick fabrics
- Complete with an automatic needle threader, fast bobbin winding system, Quick-Set bobbin and super bright LED-lit work area
- 5 styles of one-step auto-size buttonholes
- Super-wide (7mm) zigzag and decorative stitches
- Automatic needle threading
- Built-in thread cutter
- One-step bobbin replacement with quick-set drop-in bobbin
- Variable needle position
- Quilting features included
- Built-in accessory storage
- Electronic foot control
- Drop feed for free-motion quilting to create free-form or traditional quilt patterns
- Sew fleece, elastic and other stretchy fabrics with the built-in stretch stitches
- Use the built-in decorative stitches to embellish clothing, pillows, towels and more
- Create delicate family treasures using the built-in heirloom stitches
- Embellish or join quilt blocks with the built-in quilting stitches
- Bright, dual LED-illuminated sewing area
- Free arm/flatbed convertible sewing surface
- Accessories included for zipper insertion, darning, twin-needle stitching and button sewing
- Quick-change presser feet
- Stitch width and length control
- Adjustable thread tension control
- Safety power and light switch
- Lightweight with a built-in handle for portability
- Instruction booklet in English and Spanish
|Computerized, Electronic, Factory Refurbished, Quilting
|16.1 in. H x 6.7 in. W x 11.4 in. D
|25 year Limited Manufacturer
|Model Number
|Brother Sewing CE5000 Project Runway Edition
|Country of Origin
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Customer Reviews
Most Helpful
good machine, but has problems
i bought this machine about 10 months ago, and i have worked that machine about as hard as you could work it. i quilt, and i've made several quilts since i got this machine. overall, i really love it. it's small, it's lightweight, it's portable. it's easy to use. BUT... i realized i was having some tension problems, like other people have mentioned, so i decided to take it in to get a tune up. the place i took it to gave a free estimate, and they said the timing was off. they wanted to charge me almost what i paid for this machine to fix it, and that didn't sit well with me. when i told that to the guy at the repair shop, he said that the problem was that this machine has plastic gears. you mix plastic gears with heavy materials (quilting), then you're going to have problems. thankfully, i got the 2 year replacement plan, so i'm getting a full refund, and i just ordered another machine. the thing is, even with that pretty big issue, i have used it for 10 months with no problems until now. so i ordered the next one up - the CE5500. we'll see how that one does. i've never had a fancy machine, so i really don't know how this compares. all i know is that at this point i'm not prepared to pay the big bucks for a fancy machine.Read More
Sewing Machine
I didn't use this machine when I first purchased it, so I couldn't return it, and when I finally used it, it could not sew anything slightly heavy duty at all. It is fine for just minimal sewing. Last time I used it the thread pooled under the fabric, the needles kept breaking and it was just a pain to sew on because I make crafts that are different thicknesses. I finally bought another machine that sews all fabrics and thicknesses and it is sooo much nicer! Since this was refurbished when I purchase it, I can't see how repairing it again would help. I would be embarrassed to sell it to anyone for fear it would do the same thing as it did to me, and obviously the person before me.Read More
Most Recent
Great even for novices
My kids and I were clueless about how to sew, but with the good instructions and easy operation, we've made some cool stuff. We have barely scratched the surface of what this can do, and I'm looking forward to learning more.Read More
Really Nice Sewing Machine
I love this electronic machine! It is lightweight, and as an experienced seamstress, it does all that I need it to do. I like the selection of stitches, which are easily programmed by pressing the buttons. I use this machine a lot and it runs well. For under $$$, it was a very good buy.Read More
This machine is amaZing!!!
I love it. I still have it too. No problems whatsoever with it. I tell all my friends about Overstock.com all the time. I buy all of my items here and its free shipping!!!Read More
not recomended
I have owned other brothers sewing machines, but this I would like to throw right thru the window. Worlds worst machine I have ever laid hands on.Read More
Great machine
Great machine. Runs smoothly. Easy to thread. The stitches are even and constantRead More
Questions & Answers
Thank you for your inquiry; you will be contacted by Customer Care.
"Does this product come in it's original box?"
Since we buy in bulk and alot of times straight from the manufacturer we cannot guarantee packaging.
"Does this machine come with a case or cover?"
This item does not come with a carrying case.
"I have this sewing machine, but i can't find my book to it. Is there any way that i could get a book?"
We''re sorry, but we do not have any spare manuals. Please contact the manufacturer either by email or phone to order a new manual.
"What other presser feet does it come with?"
This product comes with quick-change presser feet and accessories for zipper insertion, darning, twin-needle stitching, and button sewing.
"I am having trouble with the tension on my machine. Is there a way to adjust the tension?"
The tension is automatic and controlled by a computer chip in the machine. When thread bunches up on the bottom of the material, it means that the there is a problem with the way the machine is threaded. First lift the presser bar. Then turn the tension dial to zero and then to four. Then thread the machine with the presser foot in the up position. When you get to the part where you thread the needle, lower the presser bar. When you thread the machine, remember to have the presser foot in the up position so that the thread can catch in the tension dial on the inside of the machine. When the presser bar is in the up position it opens the disks. The thread needs to go in between the two disks for the tension to work.
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How to Maintain a Sewing Machine from Overstock.com. Our guides provide customers with information about how to maintain a sewing machine.
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How to Make Your Own Pillowcases from Overstock.com. Looking for sewing projects? Need craft inspiration? Try making a pillowcase!
How to Sew an Ottoman Slipcover
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How to Make a Doll Hat
How to Make a Doll Hat from Overstock.com. Our guides provide customers with information about how to make a doll hat.
How to Choose Sewing Machine Needles
How to Choose Sewing Machine Needles from Overstock.com. Our guides provide customers with information about how to choose sewing machine needles.
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How to Troubleshoot Your Sewing Machine
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** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.

subset: commoncrawl


text: I am looking at buying a 2 stage variable speed furnace. The heating guy says that with a 2 stage variable speed furnace, BTU size is not so big a deal because the way the furnace operates, when a lower power is needed, it operates at the lower level...To me it seems size and operating at a lower power are two separate and different things. Am I wrong in thinking that these are two separate and different things? Or are they connected and not so different?


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Choreographic devices Motif development Complementary And Contrasting ClimaxUnisonCanon Question and answer Repetition, variation and development
Motifs Motif – is a sequences of action/ movements which can be developed Will consist of the six basic actions TravelBalance/stillnessJumpTurnGestureFall
Motif development Below is a list of ways in which motifs can be developed Below is a list of ways in which motifs can be developed Add or change the action Add or change the action Change the size Change the size Change the level Change the level Using different body parts Using different body parts Alter the focus Alter the focus Change the direction,dimension or plane Change the direction,dimension or plane Alter floor pattern Alter floor pattern Reverse the order Reverse the order Change the dynamics Change the dynamics Fragment the motif ie change only some parts Fragment the motif ie change only some parts Mix bits from different motifs Mix bits from different motifs
Complementary and contrasting Complementary Are movements that have already been seen but are performed using 1. different body parts 2. levels Contrast Movement which is noticeably different from anything seen so far i.e. a light slow motif can be contrasted with fast large jump
Climax Highlight The dance should be organised to gradually build towards this making it seem inevitable Final climax should confirm the audiences expectation Yet also provide an element of surprise
Canon Also can be referred: Lead and follow Question and answer Two or more dancers dancing one or more dancers dancing one or two motifs at different times Motifs are danced in succession
Canon devices Simple canon – strict order,sensitive timing and an awareness of others Simultaneous canon – dancers doing the same motif at the same time but starting from different points Cumulative canon – each dancer joins in with the lead dancer and all finish at the same time Loose canon offers more opportunity ie different levels, facing or placements
Unison The same movement at the same time Similar or complementary movements at the same time Contrasting movements at the same time
Repetition, variation and development Repetition – complete repeat of a motif Variation – when you add another action to the movement Development – you repeat it at different levels, fronts, etc
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Homemade Christmas Gift Guide
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Latest Comments
"As an avid knitter, I am always looking for new projects to make and often like to make gifts for everyone in my family. This hat and scarf set would make a great gift for the men in my life! The instructions are clear and should be easy to follow."
"Any brown paper will degrade over time unless it's coated with plastic or wax. Grocery store brown paper bags should work fine however, if you want the paper to degrade a little more quickly, most paper towels or paper napkins will work fine. The only thing I would worry about is that watering the plants will make both psper tubes and paper fall apart."
"Crafts requiring saws, blades or chemicals should be left to adults. Perhaps children could help with other aspects of the craft, such as painting or gluing."
"I agree with others who have said crafts involving chemicals, machines, blades, etc are best left to adults or with close adult supervision."
"I would have to say any craft requiring the use of machinery (IE woodworking, sewing ) is specifically meant for adults only. Anything requiring the use of chemicals as well. However these can all be taught to children in a form of respect for safety by a supervising adult D"
Santa with his Elves
By: Kathleen George for STYROFOAM Brand Foam
We are adding the craft to your Craft Projects.
The project was added to your Craft Projects.
Click here to view your Craft Projects.
Decorate your home this Christmas with some cute crafts. Santa and his elves would look perfect in a kiddy corner in the living room or in a foyer.
STYROFOAM* Brand Products:
- Cone, one 12", 10" or 8"
- Balls: one 2"; two 1"
- Disc, 1-1/4" x 6"
- Acrylic spackling compound, small amount
- Acrylic craft paint: white, peach, rose
- Wooden dowel, 1/2" x 12"
- Beads: 5/16" pink (nose); 1/2" pink, two (cheeks); 1/4" black, two (eyes)
- Cardboard, lightweight scrap (ears)
- Doll's hair or yarn (models used mohair yarn, curly yarn and curly doll's hair)
- Felt: 1/2 yd. red; small scrap fuzzy white
- Fabric: assorted scraps for apron, vest, scarf, hat
- Pompom, small white
- Ribbon, 1/4" x 12", red or green
- Teaspoon
- Flat paintbrush
- Serrated knife
- Old candle
- Scissors
- Fine sandpaper
- Wooden skewers
- Straight pins
- Thick, white craft glue
- Low temperature glue gun and glue sticks
Wax knife blade with old candle for easier cutting. Slice 1" from top of cone. Slice 1/2" from side of ball. The flat side of the ball will be glued to the side of the cone, 1" from the top. For a close fit, use teaspoon to carve a curved area on flat side of ball; rub ball and cone together until they fit snugly. Glue ball on cone, 1" from top.
Mix 1 tablespoon spackling compound with small amount of water. Brush thin coat of spackling compound on ball. Let dry, sand smooth. Gently push cheek and nose beads into foam; glue in place. Brush on another coat of spackling, covering face, cheeks and nose. Paint face peach; paint cheeks and nose rose. Glue on eyes.
Using pattern, cut two ears from cardboard; paint peach. Gently bend back edges; glue in place on side of face.
Insert a wooden skewer in each 1" ball; paint peach for hands.
Following coat diagram, cut coat from red felt. Pin coat around cone, overlapping edges in back. The bottom of coat should be flush with bottom of cone and the excess felt extends above the cone. Carefully clip felt around face. Remove coat and then glue to cone, trimming coat around face as needed. Glue edges together at top, creating pointy hat.
Using pattern, cut two sleeves from red felt; fold in half lengthwise, overlap edges 1/4" and glue.
Add trim:
- Cuffs: Fold in half lengthwise, right sides out, a 3-1/2" x 2" strip of fuzzy felt around ends of sleeves for cuffs. Glue hand to each sleeve.
- Coat: Fold in half lengthwise, right sides out, a 2" x 14" strip of fuzzy felt; glue. Glue around bottom of coat, placing seam in back; trim excess.
- Hat: Fold in half lengthwise, right sides out, a 2" x 11" strip of fuzzy felt; glue. Glue trim around hat base. Glue pompom on tip.
Cut 2 - 4" lengths of doll's hair or yarn for beard. Glue a row of hair around face; add five to six more rows under first row. Glue additional hair around hairline, if desired. Trim.
Paint disc green. Cut dowel in half (models shown have legs 6", 5-1/2" and 5" tall); paint white. Glue four pieces of 1/4" ribbons, evenly spaced, around dowels.
Using pencil, make two, 3/4" holes 1" apart in bottom of cone; glue legs in holes. Make two holes in disc; glue legs in holes.
- Dress your character:
- Apron: See pattern; cut from contrasting fabric. Glue a 1/4" x 13" length of ribbon to each side; tie ribbon in back in shoestring bow. Glue on pocket; stuff with red fabric square.
- Vest: See pattern; place dotted line on fold and cut from contrasting fabric. Thread arms through holes.
- Scarf: Fold in half lengthwise a 2" x 12" strip of fabric; glue. Glue small piece of fringe on each end. Tie around neck.
- Belt: Glue a 12" length of 1/4" - 1/2" black ribbon around cone; add a doll's belt buckle.
- Glasses: Bend two circles in a 6" brass wire; insert and glue ends into foam cone.
- Stocking cap: Fold lengthwise, right sides together, a 13" x 8" piece of fabric. Sew on the diagonal, creating a long triangle. Trim, turn right side out. Cut off existing hat and glue on new hat; trim with cuff and pompom.
- Puffy cap: Cut off existing hat and trim 1" from top of cone. Gather edges of 4" felt circle; pull thread until hat fits around head; glue. Trim with cuff and pompom.
- Buttons: Glue on gold beads.
Coat: Instead of red felt, elves can be dressed in green felt, red or green velvet, or other holiday fabric.
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