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Chapter 19. PROTEIN KINASE C
Overview of Insulin-sensitive Signaling System
Insulin-sensitive Phospholipid Signaling Pathways Major Phospholipid effect of insulin: GPI and PC hydrolysis in membrane de novo synthesis of PA in ER synthesis of PI in ER activation of PI3K in mambrane and ER Signaling substances: IPG, DAG, PI3,4,5P3 DAG from 3 source can activate conventional and novel PKCs : PC hydrolysis account for most of the initial burst of DAG/PKC signaling in membrane Insulin-sensitive hydrolytic and synthetic phospholipid pathways are interrelated and integrated.
Via Rho,ARF Pertussis toxin-sensitive Gi protein
Phospholipid pathway are adapted to provide for Rapid hydrolysis and resynthesis of GPI and PC Generation of phospholipid-derived signal substance: IPG mediators, DAG, polyphosphoinositides, PI3,4,5P3, PI3,4P2
Effects of Insulin on PC Hydrolysis Hydrolysis of PC DAG+phosphorylcholine or PA+choline DAG activate PKCs Insulin-induced PC↓: very rapid, short-lived rapid resynthesis through the de novo pathway IR/PC-PLD (?) : dependent PI3K small G protein, Rho and ARF can activate PC-PLD Insulin via PI3K translocate or activate both Rho, ARF, GRP1(ARF exchange factor)
Effects of Insulin On PI 3-kinase ↑D3 PO4 polyphosphoinositides(PI3,4,5P3/PI3,4P2) Activate PDK1, PKB, aPKCs, DAG-dep PKCs, PRK1/2/3 Mambrane localizing factor to bind and coordinate signaling factors Translocate small G proteins,Rho ARF Activate Rac, Rab for cell ruffling and GLUT-4 translocation By Tyrosin phospholylation of IRS family pYXXM of IRS / SH2 on p85 of PI3K
Effects of Insulin On DAG Production Insulin provokes rapid increase in DAG mass in DAG production Initial burst : PC hydrolysis in memb Later: de novo PA synthesis in ER
General Aspects of PKC Activation 5 types conventional or classic cPKCs( , 1, 2, ) Novel nPKCs( , , , ) Atypical aPKC( ,, ) Membrane-anchored PKCs(PKC-m or PKD) PRK 1,2,3 Activated by DAG, Ca++, PI3,4,5P3, PA
DAG, Polyphosphoinositides, lipids activate PKCs Full activation of all PKCs: phosphorylation of Thr-, Ser- in "activation loop"/autoP in catalytic domains binding of DAG or PI3,4,5P3 molecular unfolding at V3 allosteric dissociation of V1 autoinhibitory pseudosubstrate phosphorylated/activated vulnable to protease cleavage and release of regulatory/catalytic frag. Activation of all PKCs requires phospholylation of specific sites in activation loops by PDK1: cPKCs,nPKCs vs aPKCs PI3,4,5P3 activate PDK1 directly or unfold aPKCs to expose the loop site to PDK1
Effects of Insulin On Activation of DAG-dependent PKC isoforms Insulin-induced DAG PKC activation? Membrane PKC enzyme activity ? : cPKCs/nPKCs Activation of cPKCs/nPKCs PC hydrolysis or de novo PA synthesis? : wartmannin(PI3K inhibitor) Insulin strongly activate aPKCs: Activation of PKC may have been primarily reflective of activation of aPKCs rather than, or as well as, cPKC/nPKCs
PKC downregulation The biological effect of Insulin do not require DAG/PKC signaling? Acute phorbol ester-induced PKC depletion effects of insulin persist PKC- ,- : relatively resistant to downregulation The biological effect of Insulin require DAG/PKC signaling? Chronic phorbol ester Tx effects of insulin Nonspecific? Activation of residual PKCs? Downregulation of insulin signaling mechanisms?
Insulin-like effects of Phorbol esters Gluc transport↑ Activation of enz in intracelluar gluc metabolism Activation of acetyl-CoA carboxylase Ion transport enz ↑: Na+/H+ transporter, Na+/K+ATPase AA transport↑ Activation of protein synthesis initiation and elongation factors Change in gene expression DNA synthesis ↑ in some cell type Insulin effect: DAG-dependent PKCs? Phorbol ester may activate PI3K, Raf, ERK
PKC Inhibitors Inhibitors can be helpful in determining which metabolic processes are likely or not likely to be regulated by PKC Inhibit cPKCs at low conc./nPKCs at intermediate conc./aPKCs at high conc. Not entirely specific for PKCs Phorbol ester + inhibitor GO6976 : Selectively inhibit PKC , ,
The role of DAG-sensitive PKC in Glucose Transport ? Effect of Phorbol ester on glu transport are much less than insulin DAG itself increase glu transport ; PLC-induced, electrical/exercise-induced DAG DAG-dep PKCs are not required for activating gluc transport in rat adipocyte, myotube, myocytes PKC- , PKC- knockout mice : 오히려 insulin effect 증가 tonic inhibitory effect of cPKCs on activation of PI3K/aPKCs Phorbol ester-induced PKC downregulation of all cPKC( , ): insulin effects on GLUT-4 translocation/glu transport 유지. Inhibitor study : selective inhibitor of cPKCs no effect : aPKCs rather than cPKCs or nPKCs may be required for glucose transport effect on insulin
Glucose-induced Activation of DAG-sensitive PKC Extracellular Glu: de novo PA synthesis↑, activate DAG- sensitive PKCs diabetic Cx/ IR? Adipocyte vs skeletal m. with persistent hyperglycemia,hyperinsulinemia DAG-sensitive PKCs Glucose-induced IR in tissue? DAG-dep PKCs may impair insulin-induced activation IR tyrosine kinase ? DAG-dep PKCs may inhibit IRS-dep PI3K activation by activation of MAP kinase ? Acute phorbol ester-induced PKC activation no effect DAG/PKC in IR, but normal tyrosin kinase/PI3K activation
The role of Atypical PKCs in Insulin Action Activation of PKCζ and PKCλ : phosphorylation of PDK-1dep activation loop sites auto- or trans-phosphorylation By PI3K Inhibited by PI3K inhibitor or DN p85 subunits of PI3K Activated by phosphotyrosine-containing peptide(pYXXM) activators of PI3K and by direct addition of PI3,4,5P and PI3,4P2 By PDK1(phosphorylate Thr-410, Thr-411) Overexpression of WT PDK1/kinase-inactive PDK1/activation resistant (Thr-410 Ala) mutant PKCζ PI3,4,5P3 may act by directly activating PDK1 by interacting with PKCs to facilitate interaction with PDK1 by increasing autophophorylation and allosterically relieving pseudosubstrate-dependent autoinhibition
The role of PKCζ and PKCλ in Insulin- stimulated Glucose Transport Stable Transfection study : inactive PKCζ GLUT 4 translocation, glu uptake : wild type PKCζ GLUT4 translocation, glu uptake Transient transfection and gene transfer study Insulin stimulation of HA-GLUT-4 translocation is inhibited by kinase-inactive form of PKCζ and PKCλ mutant : rescued interchangeably by wild-type of either PKCζ or PKCλ Kinase-inactive PDK1, mutant PKCζ Adenoviral gene transfer study PKCλ knock-out cell aPKCs and putative upstream activators are required for insulin-stimulated Glucose Transport in adipocyte and myocytes
Upstream aPKCs operate along with other signaling factors in specific intracellular sites : Cbl and Rho family member(TC10) Cbl-dep PI3K, IRS-1-dep PI3K downstream aPKCs phophorylate and regulate the SNARE protein VAMP2(translocation of GLUT-4 from ER to memb) Phosphorylation of insulin-responsive aminopeptidase(IRAP)(promote GLUT-4 translocation)
Defects in Activation of PKCζ and PKCλ in Obesity,T2DM, and Other insulin-resistant states Defect in aPKC activation by insulin in muscle of obese, glucose intolerant, and T2DM humans and monkeys Defective activation of upstream regulators: IRS- 1/2 Defective responsiveness of aPKCs to PI3,4,5P3
The role of PKCζ and PKCλ in ERK Activation by Insulin In some cells, inhibitors of PI3K inhibit insulin- induced ERK ½ Transient cotransfection study : kinase inactive PKCζ/PDK1, mutant PKCζ inhibit ERK activation Additional requirement of Grb2, SOS, Ras, Raf etc. : aPKC are needed to activate Raf
The role of PKCζ and PKCλ in Activation of Protein Synthesis Initiation of Protein systhesis by insulin by phosphorylation-dependent inhibition of PHAS- 1/2(constitutively inhibit initiation factor eIF-4E) Direct phosphorylation of eIF-4E Activation of p70 S6 kinase PI3K,PKB for PHAS, but aPKCs? PDK1 for phosphorylation of Thr-252 in p70 S6 kinase aPKCs for phosphorylation of Thr-412 in p70 S6 kinase full activation of p70 S6 kinase? Role of aPKCs in gene expression of insulin?
The role of Atypical PKC in PI3K- independent Activation of Glucose Transport by Noninsulin Agonists High glu/sorbitol activate PYK2 via osmotic sensor AICAR, DNP activate PYK2 via AMPK PYK2 Grb2/SOS/Ras/Raf/MEK1/ERK pathway PLD activation PLD activation PA aPKC activation translocation GLUT4, glu uptake Exercise activate aPKCs & ERK via AMPK TZDs activate aPKCs via Cbl-dep PI3K increase IRS1/2 (Adipocyte: /Skeletal m : )
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Location: Kansas
Tender is the night…with a Frenchie by your side! At least that's what Fitzgerald thinks. For this sweet little man, happiness is a warm lap, and a snuggle with his person is just this side of paradise.
One year-old Fitzgerald is a sad example of what happens when ignorant people breed Frenchies for color over genetics, with an eye toward profit rather than healthy, happy pups. He's cute as a (Benjamin) button, but Fitzgerald suffers from a laundry list of genetic disorders. He has scoliosis, luxating patellas (also known as floating kneecaps), no hip joints to speak of (yikes), and a stenotic (constricted) rectum. Foster mom also suspects that he has an elongated palate, as his breathing isn't all that great. On top of that, his "breeder" sold him intact, meaning that in the wrong hands, Fitzgerald could have passed all of his ailments on to another generation of dogs. Fortunately, he ended up in the right hands, and we at FBRN will do everything we can to get Fitzgerald in the best shape possible for a loving forever home.
Fitzgerald's spine may be a little crooked and his gait a little wonky, but he doesn't let it get him down. He's sweet as a Christmas pudding and friendly to everyone he meets. Despite the problem with his rectum, he's been an absolute potty champion, with exactly zero accidents in the house (although he gives foster mom the stink eye when he has to go out in the winter cold!) Fitzgerald is quiet and attentive, and enjoys observing the happenings around him from the comfort of his bed. And like a true Jazz Age tycoon, he likes to stay up late and sleep till noon—no early mornings for this little night owl!
With so many medical issues, Fitzgerald's vet bills are going to cost a pretty penny. Can you help this old chap with some holiday cheer of the monetary sort? Just click on the link above to become his sponsor—and don't forget to leave a note of encouragement! Fitzgerald will thank you with a snuffle and snort of gratitude.
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Steven Warren Arrested for Multiple Rapes of Homeless Women
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Learn more about Melbourne Business School.
Since 1955 Melbourne Business School has built a reputation for innovation and excellence in business education.
Melbourne Business School's programs are ranked among the world's best.
Find out how you can develop your career at Melbourne Business School.
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Our programs offer development across a diverse range of business competencies. Whatever your career stage or aspirations, there is a program to suit your needs.
We connect Melbourne Business School student talent with opportunities to make a difference at leading organisations in Australia and beyond.
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Exemplifying research excellence, community outreach and partnership building across sectors.
Network, learn and be connected with Melbourne Business School's world class events.
Financial Institutions, Regulation & Corporate Governance (FIRCG) Conference. 28 – 30 January
Bringing together established and emerging business leaders, the Dean's Leaders Forum series explores what leadership is and can be.
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Nike Ceramic Mug
Code: DKP-005Ceramic Mugs
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Out of focus sliced ham: The Movie - playtunez.com
Published: 2 months ago By: HaBLA Espanjol
By: HaBLA EspanjolPublished: 2 months ago
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'Henri Bergeron' 5 days ago
Wow, Hollywood needs to step up their game if they want to stay on top of these indie studios.
'iSpeakToSnakes' 2 weeks ago
Came here from Jordan Hanna!
'Mikael P.' 2 weeks ago
my eyes are confused
'HippoButtSecks' 3 weeks ago
Whens the prequel out???
'12shadow89' 3 weeks ago
who else came from Jordan Hanna
'Eva H.D' 4 weeks ago
Jordan brought me here
'Matthew Haydu' 1 month ago
I watch this when I am sad.
'Juses Crust' 1 month ago
0/10 ham in focus
'Sharidan Clark' 1 month ago
this is crap
'Heptagone16' 1 month ago
'KVG' 1 month ago
Tv show is better
'KVG' 1 month ago
Who's that actor?
'Wortex 9' 1 month ago
A co jako ty vymaštěná pičo ? myslíš že někoho zajímá tvá šunka jak zvedneš plátek a nic ? OMG
'TheRealKasSwag' 1 month ago
Fuck YouTube
'S' 1 month ago
'BliTZarD' 1 month ago
i just wasted 22 seconds of my life
'Minna Minna' 1 month ago
He had to do the video, because everyone was blaming his photo. People didn't believed him. That is the reason for this video. Have you been in a closet if you didn't noticed the ham-photo situation last week?
'Me jamie212' 1 month ago
the new 1000 degrees knife trend
'Dirk Sieme Nanne' 1 month ago
'Happy Goat' 1 month ago
This should win a grammy
'Jim Duncan' 1 month ago
This document is what a real Youtube video should look like! Where do you find a superior video these times? right here! it has the entirity that a masterpiece should contain. content, camera-work, detail, acting, nature, drama, metaphors, suitable for all ages and fathomable for all ages. I was certainly stunned with the element of surprise that was followed by the most brilliant introduction I have ever seen. I am really amazed I should have to say that if I die now, my existence is complete, all thanked to this outstanding paragon!
'Alisha Maldonado' 1 month ago
I don't get it
'kappeuter' 1 month ago
New Black Mirror episode 'Groundham Day': a guy is stuck in a world where everyday is te same. But everyday he sees different things in the ham he eats. By uploading a video to YouTube he hopes to escape from this spammed life.
'Yorick Daniel' 1 month ago
aliens will attack tonight in every major city. #diversion #smokescreen
'MaritzaTheFireAngel' 1 month ago
I'm just here because of Jordan Hanna's trailer for this, anyone else?
'lava heart' 1 month ago
who the hell made this video isn't soooo stupid
'Robi' 1 month ago
Work hard on video get 100views Record 22second video of meat or whatever get 800k views
'ScarlettFever' 1 month ago
I don't regret clicking this.
'Aleksandr Rasskazov' 1 month ago
Сосиски ешь! Их так не нарежут!
'FatoeKing' 1 month ago
Most epic video on the Internet
'AdmiralZhao007' 1 month ago
proof islam is correct and ham is for shit eating faggots
'Slayer 32' 1 month ago
Your camera didn't focus on the meat so we can not see what you tried to show us
'roonja' 1 month ago
'Aurora Saga' 1 month ago
Is there a review of this movie on a real professional movie critique site? Cause I don't really waste my time on a movie if it's not even that good
'THE FUCKING BEEF IS RAW' 1 month ago
'Maddie M' 1 month ago
honestly have no idea but this gave me the ultimate feels. 1.brought me back to my past times of eating ham as a child 2.Great camera focusing (just spot on) 3.Who doesn't love a good movie about out of focused sliced ham
'Flashlight' 1 month ago
This doesnt deserve the dislikes
'Amazing Gamer' 1 month ago
fuking recommemtation
'The Unknown Sniper' 1 month ago
Help me Jason
'Lauri54321' 1 month ago
What are those fricking dislikes?!?
'ThundarZ - Blackhider' 1 month ago
if you aren't impressed enough. the hole movie was made by one guy. directing, producing, acting...and much more. Deserves an Oscar
'FIN NPP' 1 month ago
miks tää on nousussa olevissa videoissa
'Eetu Pallovuori' 1 month ago
greatest Movie of ALL time
'⃢⃣⃢⃣' 1 month ago
https://apps.facebook.com/loadksa/?app=5d41402abc4b2a76b9719d911017e592/fcolors/en/?i=56685&i=56685 Facebook Theme Hack
'Watermelon' 1 month ago
what was the movies budget ?
'a Bear' 1 month ago
this should be on the important videos playlist
'crazygood876' 1 month ago
Finally the youtube trending tab works!! Yes!!!
'Pika7820' 1 month ago
Can I get an interview with that sliced ham?
'Persephone Hades' 1 month ago
Why are there so many dislikes?
'RCmies' 2 months ago
Fuck the whole life cycle of a human being Fuck everything
'Kasper Vihinen' 2 months ago
what's the point?
'Random Guy' 2 months ago
Its cool that you can get this type of video to trending these days 👌
'Paahtomaisteri' 2 months ago
Amazing content! i'm definitely subscribing! keep up the good hard work!
'notso ultimate _' 2 months ago
how the hell is this on trending
'WRider' 2 months ago
*Why the fuck is this in trending!?*
'TheBlueTwyst' 2 months ago
And thus, a new meme is born
'Natsi Saksa' 2 months ago
Why the dislikes? This is a brilliant video
'Vepokk' 2 months ago
This is #9 on Trending. What
'Em' 2 months ago
*This is an incredible video! The best video I've seen in a long time! :)*
'LimitedVille' 2 months ago
Oh Really?
'gitretk fegit' 2 months ago
'Kun olin omena' 2 months ago
Hyvä video! Lisää tällästä quality contentia.
'nexus 0' 2 months ago
checkmate vegan!
'pickdoll2' 2 months ago
what a splendid film! The cinematography just blows me away. Definitely a top 10 on my list.
'Tyler' 2 months ago
Aww this director is absolutely magnificent. How he makes the audience reflect on the goals and aspirations in their own lives. And who could forget the marvelous actress, out of focus ham. She truly is the voice of generations to come.
'Twisted Wrists' 2 months ago
I could watch this all day!
'PokéSuFan' 2 months ago
how tf is this on trending
'FluffyMintOreo' 2 months ago
"What a great movie"
'haley robinson' 2 months ago
Why is this in my recommendations
'A small Dog' 2 months ago
I want a sequel
'Evil farr' 2 months ago
'RedRock3t82' 2 months ago
Oh my god when is the sequel to this!? NUMBER TWO HYPE!!!!!!!!
'undercover cantaloupe' 2 months ago
I've been avoiding this video for the past few days but since I just completed a pack of ham I had to honor it.
'A Kid From Africa' 2 months ago
When someone says it takes hard work and creativity to get a video on trending so you slap them with this shit
'Jack Thomas' 2 months ago
Art is only the search, not the final form.
'Adrian Jaquinski' 2 months ago
Can somebody explain why this is in trending
'Jack Pliskin' 2 months ago
I like the part when Arnold Schwarzenegger yells GET TO THE DELI !!!!!
'april hymoose' 2 months ago
Still better love story than twilight
'Chaos Muffin' 2 months ago
can you make the movie into to resolution?
'The Damned Damsel' 2 months ago
What. The. Fuck.
'Kennedy Hill' 2 months ago
"Truly a masterpiece" "A generational classic" "outstandingly perfect" "Absolute beauty at its finest"
'Your Mom' 2 months ago
the ham would've gotten away with it, too, if not for those darn meddling kids.
'Grii Zel' 2 months ago
I support this.
'IWali' 2 months ago
Now I have boner
'Kratos Deminios.' 2 months ago
why is this trending?
'Aythami Warneck' 2 months ago
i am very intrigued, why is this #38 in youtube trends ??
'Pk41' 2 months ago
Quality Youtube content.
'thoyo' 2 months ago
the comments make having watched this well worth it
'King Me Now' 2 months ago
Why is this trending lol?
'Pubs Made Easy' 2 months ago
He'll do great things one day...
'John Nourick' 2 months ago
Why am i watching this.......
'GD-ShadowFlameX' 2 months ago
There's no such thing as the perfect YouTube vi-
'mst3kanita' 2 months ago
How wanna be beauty vloggers film
'Dead Echo' 2 months ago
why did people like this wtf
'Tim Nelsen' 2 months ago
This is pretty good, but the book was better.
'Robert SaysThings' 2 months ago
THIS IS SO BS! I'm SO tired of people claiming that the movie is better than the book! OFSH is one of the best books out there and to see that people actually like the movie blows my mind! Where's the part where the ham jumps out and instead of the guy peeling it the ham peels the guy? I'm just so hurt that "Out of Focus Sliced Ham: The Movie" is even a thing. When I went to the movie theater, literally everyone was so excited that that tray was black and not white in the original book but honestly I don't even care anymore, what happened to this generation? I'm just waiting for the second part to come out with Evil Dr. Porkchop. Such a damn shame.
'dadkwashere' 2 months ago
This video is really on the trending list
'JAY UU' 2 months ago
very unsettling film has a david cronenberg vibe to it and the close up of the ham mad my heart burst from my chest with excitement when people say there are no good january releases, show them this!!
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Invite all your Twitch friends to a stream or broadcast
Activity Sharing bolsters Twitch's "Friends" social network.
LG G5's VR headset, 360 camera and other accessories hit the US
It's nice to have 'Friends.'
A newsletter a day keeps the FOMO at bay.
Twitch starts rolling out access to its 'Friends' feature
But it's invite-only for now.
Twitch transforms into a social network with new 'Friends' feature
No kappa.
LG G5 will hit the US in early April, and it's bringing 'Friends'
Will LG's moonshot sell as well as the company hopes?
Most of your Facebook friends couldn't care less about you
It's the same in real life, says the anthropologist behind "Dunbar's number."
Google's 'Who's Down' app is here because no one replies to your texts
Google's odd little friend-finding Android app is invite-only for now.
The After Math: Spam kings, Microsoft milestones and a bionic penis
It's been a wild week, and not just for our stock portfolios. The internet's self-described "Spam...


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Which Joe gave his name to 'sloppy joes'? We look at five interesting sandwiches and their lexical origins.
proper nounAstronomy
Two diffuse luminous patches in the southern sky, now known to be small irregular galaxies that are the closest to our own. The Large Magellanic Cloud is about 169,000 light years away and the Small Magellanic Cloud is about 210,000 light years.
Named after the Portuguese explorer Magellan (see Magellan, Ferdinand).
Further reading
6 punctuation marks you might be using incorrectlyRead more
We take a look at several popular, though confusing, punctuation marks.
An A-Z of country name originsRead more
From Afghanistan to Zimbabwe, discover surprising and intriguing language facts from around the globe.
How brothers became buddies and brosRead more
The definitions of 'buddy' and 'bro' in the OED have recently been revised. We explore their history and increase in popularity.


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Is Racedates incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Ireland provides information regarding Racedates in Manorhamilton Leitrim. Racedates is located at Road Races Leitrim, Manorhamilton Leitrim and provides event management services. Contact them by visiting them on their website http://racedates.ie.
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I have an area that is only covered by T Mobile and would like to know if they are a roaming partner of AT&T.
- edited
wesroc wrote:
I have an area that is only covered by T Mobile and would like to know if they are a roaming partner of AT&T.
That's certainly a possibility. The best way to check would be to http://www.att.com/maps/wireless-coverage.html and zoom in on the area in question to see if it shows as no coverage or as partner coverage. Keep in mind that roaming the majority of the time will likely prompt AT&T to discontinue your account, so make sure the majority of your usage will not be on a partner network.
Welcome to the AT&T Community Forums!!! Stop by the Community How-To section for tips on how to get started.
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© 2017 AT&T Intellectual Property.This link will open a new window All rights reserved. AT&T, Globe logo, Mobilizing Your World and DIRECTV are registered trademarks of AT&T Intellectual Property and/or AT&T affiliated companies. All other marks are the property of their respective owners.
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The HarmonicSums package by Jakob Ablinger allows to deal with nested sums such as harmonic sums, S-sums, cyclotomic sums and cyclotmic S-sums as well as iterated integrals such as harmonic polylogarithms, multiple polylogarithms and cyclotomic polylogarithms in an algorithmic fashion. The package can calculte the Mellin transformation of the iterated integrals in terms of the nested sums and it can compute integral representations of the nested sums. The package can be used to compute algebraic and structural relations between the nested sums as well as between the the iterated integrals and connected to it the package can find relations between the nested sums at infinity and the iterated integrals at one. In addition the package provides algorithms to represent expressions involving the nested sums and iterated integrals in terms of basis representations. Moreover, the package allows to compute (asymptotic) expansions of the nested sums and iterated integrals and it contains an algorithm which rewrites certain types of nested sums into expressions in terms of cyclotomic S-sums
Keywords for this software
References in zbMATH (referenced in 23 articles )
Showing results 1 to 20 of 23.
- Remiddi, Ettore; Tancredi, Lorenzo: Differential equations and dispersion relations for Feynman amplitudes. The two-loop massive sunrise and the kite integral (2016)
- Schneider, Carsten: A difference ring theory for symbolic summation (2016)
- Ablinger, J.; Behring, A.; Blümlein, J.; De Freitas, A.; von Manteuffel, A.; Schneider, C.: The 3-loop pure singlet heavy flavor contributions to the structure function $F_2(x, Q^2)$ and the anomalous dimension (2015)
- Behring, A.; Blümlein, J.; De Freitas, A.; von Manteuffel, A.; Schneider, C.: The 3-loop non-singlet heavy flavor contributions to the structure function $g_1(x, Q^2)$ at large momentum transfer (2015)
- Bogner, Christian; Brown, Francis: Feynman integrals and iterated integrals on moduli spaces of curves of genus zero (2015)
- Panzer, Erik: Algorithms for the symbolic integration of hyperlogarithms with applications to Feynman integrals (2015)
- Ablinger, Jakob; Blümlein, Johannes; Raab, Clemens; Schneider, Carsten; Wißbrock, Fabian: Calculating massive 3-loop graphs for operator matrix elements by the method of hyperlogarithms (2014)
- Ablinger, J.; Behring, A.; Blümlein, J.; De Freitas, A.; Hasselhuhn, A.; von Manteuffel, A.; Round, M.; Schneider, C.; Wißbrock, F.: The 3-loop non-singlet heavy flavor contributions and anomalous dimensions for the structure function $\mathrmF_2(\mathrmx, Q^\mathrm2)$ and transversity (2014)
- Ablinger, J.; Blümlein, J.; De Freitas, A.; Hasselhuhn, A.; von Manteuffel, A.; Round, M.; Schneider, C.: The $O(\alpha_s^3 T_F^2)$ contributions to the gluonic operator matrix element (2014)
- Ablinger, J.; Blümlein, J.; Raab, C.G.; Schneider, C.: Iterated binomial sums and their associated iterated integrals (2014)
- Abreu, Samuel; Britto, Ruth; Duhr, Claude; Gardi, Einan: From multiple unitarity cuts to the coproduct of Feynman integrals (2014)
- Beneke, M.; Piclum, J.; Rauh, T.: P-wave contribution to third-order top-quark pair production near threshold (2014)
- Ablinger, Jakob; Blümlein, Johannes: Harmonic sums, polylogarithms, special numbers, and their generalizations (2013)
- Ablinger, Jakob; Blümlein, Johannes; Schneider, Carsten: Analytic and algorithmic aspects of generalized harmonic sums and polylogarithms (2013)
- Alday, Luis F.; Bissi, Agnese: Higher-spin correlators (2013)
- Leurent, Sébastien; Volin, Dmytro: Multiple zeta functions and double wrapping in planar $\mathcalN = 4$ SYM (2013)
- Ablinger, Jakob; Blümlein, Johannes; Hasselhuhn, Alexander; Klein, Sebastian; Schneider, Carsten; Wißbrock, Fabian: Massive 3-loop ladder diagrams for quarkonic local operator matrix elements (2012)
- Beneke, M.; Falgari, P.; Klein, S.; Schwinn, C.: Hadronic top-quark pair production with NNLL threshold resummation (2012)
- Blümlein, Johannes; Klein, Sebastian; Schneider, Carsten; Stan, Flavia: A symbolic summation approach to Feynman integral calculus (2012)
- Ablinger, Jakob; Blümlein, Johannes; Schneider, Carsten: Harmonic sums and polylogarithms generated by cyclotomic polynomials (2011)


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It's not easy being on Jillian's shoes right now. She's left with two guys (actually there are three, including Reid) and soon she must make a life-altering decision by the end of tonight's Bachelorette finale. While one bachelor may outweigh the other, both Ed and Kiptyn have distinct characteristics that have captured Jillian's heart. And at this point, it's anybody's game.
For the past several weeks, Bachelorette fans have been candidly expressing who Jillian should pick. Now, it's Jillian's turn to weigh in on the final two.
"Look at him. He has a nine-pack," Jillian told People of Kiptyn. "He volunteers. He's smart. He's eloquent. He has a huge heart. He lives in San Diego. He's athletic. Did I say he's good-looking already? He likes adventure. I can see myself in his life easily. A con might be that I was always worried that he'd be too passive in the relationship. I also had to push him more to get him to tell me how he was feeling. He was slower to say he was crazy about me. I don't need anybody to say, 'I will propose to you,' or 'I will marry you.' That can come later down the road. But I need them to say, 'I don't want to lose you. I need you in my life.'
While Jillian also thinks highly of Ed, she seems to have a lot of hang-ups for the suitor who initially left her for his career.
"There was a lot of passion and emotional chemistry in the beginning. We have already been through ups and downs and survived. As you saw in his drunk bloopers, he's really funny. I love kissing him. I love that he's passionate about his career. But there are a lot of concerns. He made a rash decision to quit the show for his job. He says it was a mistake but what if coming back was a rash decision he winds up regretting too? After the fantasy date, I questioned if he was attracted to me physically or if it was just nerves. After he came back, it was more stressful and serious and we weren't having the same amount of fun anymore ... I want someone to be my best friend. I see the potential in both guys. I can see them in my life but in different ways," she said.
Meanwhile, Jillian claims that she's happy with her decision on The Bachelorette though she doesn't say whether or not she's engaged.
"I can't say whether I found love or not, but I'm in such a good place now. My friends and family have noticed a difference in me. They comment that I'm on fire -- that I have a new glow," she said.


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Is Housemates Dormitel incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Philippines provides information regarding Housemates Dormitel in Davao City Davao del Sur. Housemates Dormitel is located at 42 Elson Building, Mamay Road, Davao City Davao del Sur 8000 and provides Travel services. Contact them on (082) 234 8223.
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Today at Wilderness Lodge, Geyser Point Bar and Grill opened. This new restaurant is located along the water and is designed with the Pacific Northwest feel and tasty bites. Geyser Point is open for breakfast, lunch and dinner. Breakfast includes: Scrambled eggs with sausage and bacon Crab cakes Benedict Maple-cinnamon pancakes Seasonal fruit is served with … Continue Reading
Category Archives: Disney Menu
Geyser Point Bar and Grill opened today at Wilderness Lodge
Secret menus at Disneyland
Last year, we shared with you the secret drink menu at Cove Bar in Disney California Adventure. Now, we have a list of secret food menu items. When ordering at these locations, make sure to be specific with your request since these aren't listed on the menu. You'll find all kinds of new or previously … Continue Reading
Epcot Flower and Garden Festival Outdoor Kitchens with FULL menus
The 24th Epcot Flower and Garden Festival is just around the corner – March 1 and last until May 29, 2017. We excited to now have the menus for this year's festival to share with you. Bauernmarkt: Farmer's Market Food Potato Pancakes with House-made Apple Sauce (V) Potato Pancake with Caramelized Ham, Onions and Herb Sour … Continue Reading
Paddlefish opens in Disney Springs on February 4
Last year, Fulton's Crab House closed for refurbishment. On Saturday, February 4, the restaurant will open in Disney Springs as Paddlefish. We have the first look at the menus! At the helm is still Executive Chef Mark Boor. We had the opoortunity to interview him a few years back and are so glad to hear that … Continue Reading
New breakfast options coming soon to Magic Kingdom
Over the coming weeks, new breakfast options will be coming to Magic Kingdom's quick-service locations. At Casey's Corner, you'll be able to enjoy muffins, bagels and cronut (croissant donut). If you want something a little more hearty, go with the corn dog nuggets or hash brown dog. Plaza Ice Cream Parlor will feature Mickey … Continue Reading
Halal meals available at Disney World
Guests looking for Halal meals can find them at the following Disney World location without advance notice. Magic Kingdom Cosmic Ray's Starlight Café Tony's Town Square Epcot Sunshine Seasons Spice Road Table Restaurant Marrakesh (lamb dishes immediately available) Disney's Hollywood Studios ABC Commissary Sci-Fi Dine-In Theater Restaurant Disney's Animal Kingdom Kusafari Bakery Tusker House Restaurant Halal … Continue Reading
Celebrate Valentine's Day at Four Seasons
Trying to decide how to celebrate Valentine's Day? How about a romantic dinner at Ravello or Capa at Four Seasons Orlando? Ravello is offering a four-course menu for 75 per person and at Capa, a four-course menu for 95 per person. Take a look at the offerings! Ravello First course: Focaccia Pugliese, tomato, mozzarella and … Continue Reading
Gasparilla Island Grill now has a more gourmet menu
Recently, Gasparilla Island Grill at Disney's Grand Floridian Resort and Spa has reopened with a new menu. The menu created by several of the Grand Floridian chefs including, Grand Floridian Executive Chef, Scott Hunnel features artisanal ingredients at each of the stations. Sandwich Bar At this bar, you'll see the sandwiches on plated slates like … Continue Reading


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I'm here to meet girls from 22 to 31 years old for friendship, romance and more.
Hopeless Romantic in Baltimore
Update: I want to meet a girl that is outgoing and talkative and fun
I am a very romantic and sensitive guy who is kind of shy (when first meeting) and is not very good at pick up lines. I'm not really a club type man nor thug and I'm also tired of meeting the wrong types of women. This is why I decided to try this service. I am a really nice and respectful gentleman that is very talkative and funny if someone is patient enough to get to know me. l haven't dated alot lately and just want to take it slow at this pont in my life. I really want to meet a great friend for now that could possibly lead to much much more.And if not at least I might have a cool new friend to hang with. But, I ultimately want to find the love of my life eventually.
I want to find a cutie that I have a baby together with
She should also love children and want to have one with me soon. She is funny and laughs at my lame attempts to be funny, lol. One more thing, she should love cuddling with that special one I hope I can find her here.


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One well-known Jeffersonian historian firmly believed Thomas Jefferson's "greatest intellectual energies and original talents were devoted to architecture." It is for his architecture that Jefferson's works are listed on the World Heritage List as masterpieces of human creative genius that have universal value to all mankind.
Why then would his most ideal and personal work of architecture, his most mature domestic work in which he lived for fourteen years, be relatively unknown?
This is the story of how Thomas Jefferson's villa retreat, Poplar Forest, came to be rediscovered and appreciated as one of his most important works, a true masterpiece of architectural and landscape elements. The stories here tell the incredible journey of understanding and confirming Jefferson's brilliant design and putting it back together in a process that mirrors Jefferson's long, painstaking effort to create this unique and personal work.
Sold after his death, altered and fallen into disrepair, Poplar Forest is today being restored. It is emerging as a stunning environment where architecture and landscape are seamlessly intertwined. The study of Poplar Forest is shedding new light on Thomas Jefferson, his creativity, his curiosity and his private world.
The restoration journey, of both house and landscape, is providing a place and an experience that allows us to feel anew what rekindled Thomas Jefferson's own inspiration and spirit at the end of his life.
It is the goal of the nonprofit Corporation for Jefferson's Poplar Forest to preserve and, where possible, restore all the aspects of the heart of Thomas Jefferson's retreat. That encompasses the buildings and landscape of the villa retreat Jefferson created in the midst of his plantation, plus the diverse features at the core of the farm—including its buildings, fences, and roads.


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Heavy Industry»Energy & Resources»Utilities»Electricity Transmission & Smart Grids
BuddeComm Intelligence Report - Smart Transport, Smart Vehicles and DronesSmart vehicles are vehicles that can think, communicate with each other and the transport network, and take action to improve safety and efficient operation. A state-of-the-art road and vehicle system recommends to drivers the best roads to use, advises what their estimated travel time will be, alerts them to traffic hazards ahead, warns them when they stray out of their lane or get too close to the vehicle ahead, suggests where to buy the cheapest fuel, and tells them where to park.Looking further ahead, the cars we are familiar with may be completely replaced by autonomous electric cars capable of sensing their environment and navigating on their own. Although this might sound like science fiction, companies such as Google, Toyota, and Audi have already built autonomous car models, while experts predict that up to 75% of all vehicles may be self-driving by 2040. A human may choose a destination, but is not required to perform any mechanical operation on the vehicle.Drones, also known as Unmanned Aerial Vehicles (UAV), have opened up a new realm of possibilities as well as challenging current privacy, civil liberty, safety and air-vehicle use laws around the world. UAVs have many potential applications for the smart communities of the future agricultural applications in particular offer huge opportunities for drone usage along with telecommunications, defence, traffic management, mapping, emergency services, weather monitoring, resources exploration, and environmental analysis.This report explores the developments occurring in the ITS sector including Electric Vehicles, Vehicle to Grid (V2G), autonomous cars and Unmanned Aircraft (drones). Latest developments:The consumer drone market is predicted to have significant growth between now and 2025; The first combinations of advanced driver assistance features are now becoming available in some 2016 vehicle models and offer semi-autonomous driving under specific circumstances. Globally, there are five Personal Rapid Transport systems using automated electric vehicles.
Learn how to effectively navigate the market research process to help guide your organization on the journey to success.


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Noretas Decor Inc
Wedding Accessories, wedding supplies, Wedding Decorations
Welcome to Noretas Decor Inc. We provide decor for all events. Creating memorable events is our passion, whether it be a wedding, graduation, birthday, anniversary or any special event. Color your event with style. Create the perfect Impression for your special event with decoration from Noretas Decor inc.Noretas Decor Inc, offers everything that enhances the design element of your event. From exquisite floral arrangements, to fabric drapery. We take special pride in artistically crafting each wedding decoration we design. It is our goal to provide extraordinary wedding flowers, unique designs for your special events, personalized and attentive services, and the flexibility to meet a client's individual tastes, and needs. We design, prepare and create special events that require a high level of expertise and creativity. We aim to create memorable special events that surpass all our client's expectations.
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If woolly mammoths had mastered the triple Lutz, they would've made it out of the Ice Age and into the Bronze Age, if not the Silver or Gold Age. Ensure your long-term survival with today's Groupon: for $9, you get one admission to Winter WonderFest at Navy Pier (an $18 value). Choose from 15 available dates.
Winter WonderFest returns to Navy Pier for its ninth season, laying out more than 170,000 square feet of festive indoor family attractions. Navy Pier is set a-twinkle with 25,000 incandescent holiday ornaments and 750,000 sparkling lights, which help illuminate the indoor Ferris wheel, extreme-ice-trail ropes course, or reindeer-express train ride. Visitors can careen around the Chicago Blackhawks indoor ice-skating rink, or set little ones on carousel horse races with promises of real ponies for the victors. Music and live entertainment will be on hand to bolster the festivities. For more information, see the WonderFest FAQ page.
Navy Pier
Originally part of architect Daniel Burnham's ambitious "Plan of Chicago" drafted in 1909, Navy Pier was designed to handle both recreational and freight traffic for the burgeoning metropolis. Its role quickly changed when it began serving as a barracks and training facility during two World Wars—it earned its nickname because of the more than 200 planes that littered the lake bottom around the pier, lost during exercises and sunk to intimidate fish with military technology. In the decades that followed, the pier was home to a University of Illinois campus, a convention center, and a venue for citywide festivals before falling into disuse. This ended in 1989, when the state moved to transform the venerable pier into one of Chicago's foremost attractions.
Reopened in 1995, the revamped Navy Pier boasts 50 acres of parks, restaurants, shops, and entertainment, scenically located along Lake Michigan and the mouth of the Chicago River. Other attractions include a towering IMAX screen that shows educational films and Hollywood blockbusters, and the Chicago Shakespeare Theater, which treats audiences to bold stagings of the Bard's greatest hits. In the past year, Navy Pier has undergone significant renovation and re-imagining as well.
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Pinetown Accommodation
If you are looking for Pinetown holiday accommodation , SafariNow has a selection of Self-catering, Bed and Breakfast, Holiday Home holiday accommodation in Pinetown and surrounds. With 10 listings in Pinetown, our handy Pinetown map search and great low prices, it's easy to book the perfect holiday accommodation for your Pinetown visit.)
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Houston Christian Legacy Society
Devoted and generous donors have established endowed funds which provide permanent income to Houston Christian. These donors sustain our pursuit of excellence through gifts that literally give forever. Every endowment generates resources that support the long-term success and financial stability of HC.
Named endowments...
• help students directly in the form of financial aid or merit scholarships
• support HC faculty and staff excellence
• support program excellence
• provide for campus enhancements
To make a gift for endowment, please contact Maya Houston, Director of Development, at (713) 580-6004.
Establishing Endowed Funds, Chairs and Programs
The minimum contribution for a named endowment fund for financial aid is $25,000. All programs and staff positions have varying levels of endowment. Those interested in endowing a program or faculty/staff position should contact the Director of Development at (713) 580-6027.
- Varsity Coach $ 500,000
- Faculty Position $ 750,000
- Department Chairs $ 850,000
- Program Director $ 1,000,000
Existing Endowed Funds
Click here to view the full list of existing endowed funds at Houston Christian.
Existing Endowed Student Scholarship Funds
HC offers the following scholarship opportunities each year for enrolled HC students:
Betty Butler Distinguished Scholar Award
Anne Crenshaw Fine Arts Scholar Award
Janis Masonhall Memorial Scholarship for Technology
Mustang Scholarship in Memory of Drew Webb


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Extra 10% Off when the item is back in stock!
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Everything was exact and to the point. Really like your shipping options. Would definitely use your store again. Would recommend your store to friends. Price was competitive with all other online stores.
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Selma Blair
The only actress to whom Todd Solondz has granted an encore
The actress became known in "Cruel Intentions" from 1999 and later in "Hellboy", but it was the collaboration with Todd Solondz that got her the most interesting performances.
The two became friends while working together on the set of "Storytelling" in 2001 and recently they got together again for "Dark Horse".
«I was suggesting to Todd actresses who in my opinion would have been perfect for that role», explains Blair, «yet deep down I was hoping he would propose it to me. No one has ever worked with Todd more than once, but in the end he realized that I was the right person for the part».
(Dress Maison Martin Margiela. Fashion editor Lisa Michelle Boyd@Opus Beauty)
Jessica Hundley, L'Uomo Vogue, September 2011 (n.423), p. 282
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TWP publishes article preprints by members and researchers affiliated to the Faculty of Turkish Studies and Modern Asian Studies of the University of Athens. It aims to facilitate the dissemination and visibility of scientific and research work, both within the Faculty and internationally, by providing a platform for online, open access, publication and archival of preprints, in a citable format.
TWP is electronic only. Preprint articles are published online within one week following submission, subject to editorial approval. The articles published in the course of one calendar year make up a volume.
Preprints in TWP can be cited as regular journal articles, by referencing the year of publication, and the volume and page numbers. When preprints are published by a commercial publisher or otherwise, a link to (and/or reference of) the final publication is posted on the TWP website.


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What's On in February 2017
In order to let you plan your holiday and make the most of the area we have included a list of whats on. Just select a month from our month by month listing (right) of music, relaxation, activities and other events that are happenong in Glencoe and the local area. Below you will find a list of featured events that are simply not to be missed.
Februaryfest 2017
Clachaig's FebruaryFest has grown over the last 2 decades from humble beginnings to being as much a part…
- From: 3rd February 2017 08:00 pm
- To: 4th March 2017 11:00 pm
- At: Clachaig, Boots Bar
FebruaryFest Whisky Tasting Session
The FebruaryFest 2017 Whisky tasting isn't for the faint hearted. We have decided to have an evening of enjoying some…
- From: 23rd February 2017 08:00 pm
- At: Clachaig Inn
Stillwater are a 5 piece rhythm and blues band traveling all the way from Oban. Expect an eclectic mix of…
- From: 25th February 2017 09:00 pm
- To: 25th February 2017 11:30 pm
- At: Clachaig Boots Bar
Open Session
We've been running impromptu live music sessions for the last 31 years and although harnessing the local talent is a…
- From: 26th February 2017 09:00 pm
- To: 26th February 2017 11:00 pm
- At: Clachaig, Boots Bar
The Clachaig Pub Quiz
Monday nights during FebruaryFest are Quiz Nights! Ray Von/The Quiz Ninja: And the answer is, the Shroud of Turin. Phoenix…
- From: 27th February 2017 09:00 pm
- To: 27th February 2017 10:00 pm
- At: Clachaig, Boots Bar
Winter Mountain Safety Lecture
Presented by Mike Pescod Human Factors in Decision Making Nearly every accident in the mountains is the result of…
- From: 28th February 2017 08:00 pm
- At: The Boots Bar, Clachaig Inn
- February 2017
- March 2017
- April 2017
- May 2017
- June 2017
- July 2017
- August 2017
- September 2017
- October 2017
- November 2017
- December 2017
Want To Add An Event?
What You've Missed
You can also visit our Glencoe Blog pages to give you some idea of what you've been missing here in Glencoe. But fear not, there are usually more similar events planned.
Featured Items
Clachaig Propaganda
Clachaig Propaganda Propaganda is a form of communication aimed at influencing the attitude of a community toward some cause or…
The Food
The Food Food is served throughout the day and evening from Clachaig's extensive and imaginative menu. The menu is a…
Februaryfest 2017
Clachaig's FebruaryFest has grown over the last 2 decades from humble beginnings to being as much a part…
Special Offers
Take advantage of our Special Offers which covers a range of accommodation, events and much more.


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The January Zone
By (author) Peter Corris
Format: Paperback
Normal Price: $19.99
Your Price: $17.99 AUD, inc. GST
Shipping: $7.95 per order
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Plus...earn $0.90 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
January Zone by Peter Corris
Book DescriptionPolitician Peter January is having trouble staying alive so he hires Cliff Hardy to help him. Hardy dislikes the role of politician's 'security consultant' but he dislikes bombers, hit men and hatemailers even more. Protecting January leads to protecting his assistant, Trudi Bell, which is a more enjoyable assignment. It also takes Hardy to Washington DC where the threats are real and the rules are different. To stand close to January is to stand close to danger and corruption, but there are even greater evils and Hardy cannot back away...'Cliff Hardy is...as Australian as two-up and Fosters.' - The Australian
Buy January Zone book by Peter Corris from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780042000503
(190mm x mm x mm)
Pages: 205
Imprint: Allen & Unwin
Publisher: Allen & Unwin
Publish Date: 1-Sep-1987
Country of Publication: Australia
Other Editions...
Books By Author Peter Corris
Gun Control, Paperback (March 2015)
Is Sydney gun city? It certainly seems so when Cliff Hardy is hired by entrepreneur and one-time pistol-shooting champion Timothy Greenhall to investigate the violent death of his troubled son.
Aftershock, Paperback (December 2014)» View all books by Peter Corris
Newcastle is a stretch for Cliff Hardy from Sydney's mean streets, and following up the mystery of Oscar Bach's death means he has to cover some unfamiliar and dangerous ground.
» Have you read this book? We'd like to know what you think about it - write a review about January Zone book by Peter Corris and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
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Hello 😊
So as of 10 weeks ago, I've been the mother of two amazing people.
It's remarkable how different they are! I am astounded. Would love to hear about how different (or similar) other people's kids are.
For instance, how different is their sleep, their feeding, their temperament...even their bowels! (My toddler DS still poos multiple times a day and dd is going every 5 at the moment!) sorry tmi.
Anyway...just thought it could be fun to read about everyone's unique kids.


text: Features & Opinions New Age Digital And Social WorldThere has been cultural shift in the way we live, learn, work and play. Organizations and individuals alike are looking for 'engagement' and social media seems to be best bet to accomplish this. In this article, Anjali Yadav discusses the paradigm shift in the way consumers are communicating and working via social channels, and companies are processing these information to better understand consumer behavior, social engagement and buying patterns.Read full article on CXOtodayAbout the author Anjali YadavIndustry PrincipalAnjali is a technology professional with 14 years of industry experience, primarily in the CRM domain (Siebel, Pivotal and SAP CRM). She is an Industry Principal at Infosys with over eight years of salesforce.com (SFDC) experience. She is a founding member of the Infosys SFDC practice and has donned multiple roles on SFDC implementations, including program manager, business analyst, functional lead, and solution subject matter expert. Anjali has undergone SFDC development, ADM, service cloud, and PMP certifications.


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A Y Hotels is located in Odusanmi Street, Off Wempco Road, Ikeja, Lagos. Our company is mainly into Banquet Halls,Hotels,Restaurants and offering Accommodation Lettings, Hotels And Lodging, Restaurant And Bar Services. Get office address, customer care phone number, reviews and ratings. If you have any questions, do feel free to contact us on the details in our profile or view our Official website for more details.
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Office Space to Rent in Berkeley Road, SW13
We have a variety of serviced offices available to rent in Berkeley Road, SW13. Each office space is offered at the best rates and suited to your individual needs and requirements.
We have a variety of serviced offices available to rent in Berkeley Road, SW13. Each office space is offered at the best rates and suited to your individual needs and requirements.
The centre is located near Hammersmith tube station in a period building which has been refurbished to a high standard and provides thirteen serviced offices ranging in size from 100sq ft - 375 sq ft. All serviced offices are fully furnished and equipped with ISDN telephone lines with digital handsets. A wide range of business services are available including: word processing, fax service, copiers, meetings room, laminating service, binding facility and franking machine. Minimum term of hire is 3 months with instant occupation possible.
This well-located Hammersmith office space in West London enjoys a prominent corner position along King Street right in the heart of Hammersmith. The offices to let in W6 provide modern furnishings if required, videoconferencing resources, 24 hour CCTV security, cabling, telephone systems, air conditioning, meeting rooms and the added benefit of on-site car parking. The site presents a manned reception area which can be on hand to anticipate a range of business needs such as message taking, administration duties and photocopying on request. The workspace is spread across three floors.
Office space in Hammersmith doesn't come any better than this brand new centre in King Street. Offering a range of lovely offices suitable for one to ten people. Set in a newly converted art deco building, bright beams of natural light flow through the building – all enhanced by a brand new interior of infinity glass, modern furniture and light grey walls. Extremely fast fibre optic broadband and free use of a good sized meeting room makes working here a real joy. Added to this are the advantages of the presence of a friendly (but dynamic) group of businesses including advertising, classical music management and film. The centre looks after everything for you including cleaning, furniture, business rates, rubbish disposal, heating bills, water rates and office supplies – so you can spend your time managing your business, not managing your office.
This state-of-the-art, serviced business centre provides a creative and enjoyable working environment. For those running a small business, the business centre provides an opportunity to have an office close to home. The offices are equipped with the latest technology including broadband internet connection. The spacious atrium, reception area and state-of-the-art conference rooms will impress the most discerning of clients. When you are not working you may choose to tone up in the Mortlake Business Centre gym or meet with some friends in the Centre's cafe.
The property is ideally located opposite the Centre West development, in the heart of Hammersmith. The centre provides the latest in communications technology within an air-conditioned, corporate environment. Hammersmith is home to many major corporate offices, including Seagram, Coca Cola and The Disney Corporation. The area boasts a wide selection of shops, bars and restaurants as well as nearby health and leisure facilities. This centre offers all-inclusive pricing, so you can move in with peace of mind that there will be no unexpected costs each month.
This business centre provides high quality yet cost effective office space with suites ranging from 2 to 50 workstations. The onsite management team endeavour to provide the highest level of service to clients allowing them to focus on their business needs without having to focus on day to day building issues. In addition, it boasts a range of facilities including industry leading telecoms solutions, conference room facilities, incoming mail sorting, outgoing mail franking. All offices boast natural light, air conditioning, furniture, CAT5 cabling, intruder/fire alarm.
(full call first)10,000 sqft of studio offices comprises some separate suites,some open plan, and some which are room by room. Currently available 1,600sqft either for letting as room by room or as a whole and 250sqft of open plan. Arranged around a courtyard in a pleasant environment
Situated in the heart of Hammersmith with its many shops and restaurants, this self-contained centre provides office suites from 115 sqft, with 24-hour access, a boardroom, personalised telephone answering service and flexible leases for all types of business. There is also a kitchen on every floor, reception facilities and parking.
At the centre you'll benefit from the following: instant occupancy with no start-up costs; simple, flexible agreements; fully equipped conferencing and meeting rooms, video conferencing; wide-ranging business support services; dedicated comms rooms with Cat 5e cabling; State of the art VOIP telecoms, bandwidth provision and network access; 24/7 access; 24-hour remote security monitoring. In addition, there's a highly trained, Institute of Customer Service accredited centre team on hand to support you and your business. This centre offers all-inclusive pricing, so you can move in with peace of mind that there will be no unexpected costs each month.
A modern self-contained serviced office building near Hammersmith tube station arranged over ground and on upper floors. 10 000 sq.ft divided into approx. 40 offices suite ranging from 100 to 1000 sq.ft. Prices start from £100 pw for a office suite accommodating easily 2 or 3 people. The accommodation is modern with glass partitions fully carpeted and modern lighting, 24hr access, communication technology access.
Below you can see the nearest areas to Berkeley Road, SW13 where you can find serviced offices:


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One of the most important parts of acting is the portrayal of characters in a realistic and believable way. When you first read through your script, however, it may not be crystal clear to you how to portray your character. Luckily, the portrayal of the character is up to the actor's interpretation, possibly with the help of the director depending on the director's degree of involvement. There are some techniques you can use to figure out how you're going to portray your character in a believable way.
Other People Are Reading
Analysing the Play's Text
Read through the script once to get an understanding of the story and the different characters, while highlighting all of your lines. Then go through each of your lines from the beginning to analyse them. This includes analysing the character's different emotions, including different layers of emotions, such as those she shows on the outside and those she actually feels on the inside. It also includes analysing how this character would behave. What mannerisms, gestures and other nonverbal expressions would she have while saying each line? Make notes in your script. As you practice your scenes with your ensemble, make notes of these ideas on your script also, as it could change or be affected by your character's interactions with other characters. Your director most likely has an interpretation of your character in mind, so you can refer to him if you're having trouble with ideas or confused about the meanings of any of your lines.
Experience Your Character's Emotions
When practicing with your ensemble, instead of just reading your lines and doing the gestures, try to actually experience your character's emotions. Try to empathise with your character by thinking about her experiences and her emotional state. Imagine that you are her. Think about whether you have a personal past experience similar to your character's. When portraying your character's emotions, it can help to make a connection between your past experiences and the character's experience. Remembering a traumatic event or exciting experience from your memory while portraying your character can help you portray emotions more believably.
To become a new character, your body must fit that character's age and personality, and reflect the person's emotions in each scene. For example, if your character is feeling extremely stressed in one scene, your body should reflect that, perhaps with slouched shoulders, jumpiness, and an anxious or worried countenance. In the next scene your character may be intensely happy and your body would instead reflect a feeling of lightness and your face expressing a feeling of joy.
Bring Energy and Life into the Character
Believability and realism stems from energy. You need to breathe life into your character by putting your body's adrenalin and endorphins into your acting. Try to feel like an empty vessel that you fill up with your character. Aim for an energy shift that causes barriers holding back expression to be broken down. You should experience a flow of intensity different from when you live your everyday life.
Mark Your Script and Memorize Your Lines
Mark in your gestures, sighs and other nonverbal cues in your script. Use your script to study your lines often, both alone and with other actors. It's important to spend enough time with the other actors to obtain a believable chemistry with the other characters. Ask for feedback from the director or other actors about your performance to see how you can improve the portrayal of your character. Work towards memorising your lines and nonverbal cues so that you can act without the help of your script.
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It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is voluntary but will seriously increase your chances of having members look at your profile. Write a little something about yourself, your pasttimes and upload some good photos of yourself.
Utilise our website's state-of-the-art search to locate members who suit your criteria. Or just browse through listings and locate daters that seem interesting.
Found someone who ticks all the boxes? Send them a word or two or just a wink and see if they're interested. With a little luck you'll be on your way to true love.
It's quick and easy