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Combining PET images and neuropsychological test data for automatic diagnosis of Alzheimer's disease
Segovia-Román, Fermín ; Bastin, Christine ; Salmon, Eric et al
in PLoS ONE (2014), 9(2),
In recent years, several approaches to develop computer aided diagnosis (CAD) systems for dementia have been proposed. Some of these systems analyze neurological brain images by means of machine learning ... [more ▼]
In recent years, several approaches to develop computer aided diagnosis (CAD) systems for dementia have been proposed. Some of these systems analyze neurological brain images by means of machine learning algorithms in order to find the patterns that characterize the disorder, and a few combine several imaging modalities to improve the diagnostic accuracy. However, they usually do not use neuropsychological testing data in that analysis. The purpose of this work is to measure the advantages of using not only neuroimages as data source in CAD systems for dementia but also neuropsychological scores. To this aim, we compared the accuracy rates achieved by systems that use neuropsychological scores beside the imaging data in the classification step and systems that use only one of these data sources. In order to address the small sample size problem and facilitate the data combination, a dimensionality reduction step (implemented using three different algorithms) was also applied on the imaging data. After each image is summarized in a reduced set of image features, the data sources were combined and classified using three different data combination approaches and a Support Vector Machine classifier. That way, by testing different dimensionality reduction methods and several data combination approaches, we aim not only highlighting the advantages of using neuropsychological scores in the classification, but also implementing the most accurate computer system for early dementia detention. The accuracy of the CAD systems were estimated using a database with records from 46 subjects, diagnosed with MCI or AD. A peak accuracy rate of 89% was obtained. In all cases the accuracy achieved using both, neuropsychological scores and imaging data, was substantially higher than the one obtained using only the imaging data. [less ▲]Detailed reference viewed: 137 (23 ULg)
Do Photobiont Switch and Cephalodia Emancipation Act as Evolutionary Drivers in the Lichen Symbiosis? A Case Study in the Pannariaceae (Peltigerales)
Magain, Nicolas ; Sérusiaux, Emmanuël
in PLoS ONE (2014), 9(2), 89876
Lichen symbioses in the Pannariaceae associate an ascomycete and either cyanobacteria alone (usually Nostoc; bipartite thalli) or green algae and cyanobacteria (cyanobacteria being located in dedicated ... [more ▼]
Lichen symbioses in the Pannariaceae associate an ascomycete and either cyanobacteria alone (usually Nostoc; bipartite thalli) or green algae and cyanobacteria (cyanobacteria being located in dedicated structures called cephalodia; tripartite thalli) as photosynthetic partners (photobionts). In bipartite thalli, cyanobacteria can either be restricted to a well-delimited layer within the thallus ('pannarioid' thalli) or spread over the thallus that becomes gelatinous when wet ('collematoid' thalli). We studied the collematoid genera Kroswia and Physma and an undescribed tripartite species along with representatives of the pannarioid genera Fuscopannaria, Pannaria and Parmeliella. Molecular inferences from 4 loci for the fungus and 1 locus for the photobiont and statistical analyses within a phylogenetic framework support the following: (a) several switches from pannarioid to collematoid thalli occured and are correlated with photobiont switches; the collematoid genus Kroswia is nested within the pannarioid genus Fuscopannaria and the collematoid genus Physma is sister to the pannarioid Parmeliella mariana group; (b) Nostoc associated with collematoid thalli in the Pannariaceae are related to that of the Collemataceae (which contains only collematoid thalli), and never associated with pannarioid thalli; Nostoc associated with pannarioid thalli also associate in other families with similar morphology; (c) ancestors of several lineages in the Pannariaceae developed tripartite thalli, bipartite thalli probably resulting from cephalodia emancipation from tripartite thalli which eventually evolved and diverged, as suggested by the same Nostoc present in the collematoid genus Physma and in the cephalodia of a closely related tripartite species; Photobiont switches and cephalodia emancipation followed by divergence are thus suspected to act as evolutionary drivers in the family Pannariaceae. [less ▲]Detailed reference viewed: 48 (3 ULg)
Hybridization capture using short PCR products enriches small genomes by capturing flanking sequences (CapFlank)
; ; et al
in PLoS ONE (2014), 9(10),
Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates ... [more ▼]
Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates kilo to gigabases of high confidence consensus targeted sequence. However, in many experiments, a non-negligible fraction of the resulting sequence reads are not homologous to the bait. We demonstrate that during capture, the bait-hybridized library molecules add additional flanking library sequences iteratively, such that baits limited to targeting relatively short regions (e.g. few hundred nucleotides) can result in enrichment across entire mitochondrial and bacterial genomes. Our findings suggest that some of the off-target sequences derived in capture experiments are non-randomly enriched, and that CapFlank will facilitate targeted enrichment of large contiguous sequences with minimal prior target sequence information. [less ▲]Detailed reference viewed: 9 (1 ULg)
High Diversity in Cretaceous Ichthyosaurs from Europe Prior to Their Extinction
Fischer, Valentin ; ; et al
in PLoS ONE (2014), 9(1), 84709
Background: Ichthyosaurs are reptiles that inhabited the marine realm during most of the Mesozoic. Their Cretaceous representatives have traditionally been considered as the last survivors of a group ... [more ▼]
Background: Ichthyosaurs are reptiles that inhabited the marine realm during most of the Mesozoic. Their Cretaceous representatives have traditionally been considered as the last survivors of a group declining since the Jurassic. Recently, however, an unexpected diversity has been described in Upper Jurassic–Lower Cretaceous deposits, but is widely spread across time and space, giving small clues on the adaptive potential and ecosystem control of the last ichthyosaurs. The famous but little studied English Gault Formation and 'greensands' deposits (the Upper Greensand Formation and the Cambridge Greensand Member of the Lower Chalk Formation) offer an unprecedented opportunity to investigate this topic, containing thousands of ichthyosaur remains spanning the Early–Late Cretaceous boundary. Methodology/Principal findings: To assess the diversity of the ichthyosaur assemblage from these sedimentary bodies, we recognized morphotypes within each type of bones. We grouped these morphotypes together, when possible, by using articulated specimens from the same formations and from new localities in the Vocontian Basin (France); a revised taxonomic scheme is proposed. We recognize the following taxa in the 'greensands': the platypterygiines 'Platypterygius' sp. and Sisteronia seeleyi gen. et sp. nov., indeterminate ophthalmosaurines and the rare incertae sedis Cetarthrosaurus walkeri. The taxonomic diversity of late Albian ichthyosaurs now matches that of older, well-known intervals such as the Toarcian or the Tithonian. Contrasting tooth shapes and wear patterns suggest that these ichthyosaurs colonized three distinct feeding guilds, despite the presence of numerous plesiosaur taxa. Conclusion/Significance: Western Europe was a diversity hot-spot for ichthyosaurs a few million years prior to their final extinction. By contrast, the low diversity in Australia and U.S.A. suggests strong geographical disparities in the diversity pattern of Albian–early Cenomanian ichthyosaurs. This provides a whole new context to investigate the extinction of these successful marine reptiles, at the end of the Cenomanian. [less ▲]Detailed reference viewed: 54 (5 ULg)
PCB-153 shows different dynamics of mobilisation from differentiated rat adipocytes during lipolysis in comparison with PCB-28 and PCB-118
; ; et al
in PLoS ONE (2014), 9(9), 106495Detailed reference viewed: 11 (0 ULg)
Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery.
; ; et al
in PloS one (2014), 9(1), 85667
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide ... [more ▼]
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex structures with cycles and branches. Moreover they often contain non proteogenic or modified monomers, such as the D-monomers produced by epimerization. We investigate here some sequence specificities of the condensation (C) and epimerization (E) domains of NRPS that can be used to predict the possible isomeric state (D or L) of each monomer in a putative peptide. We show that C- and E- domains can be divided into 2 sub-regions called Up-Seq and Down-Seq. The Up-Seq region corresponds to an InterPro domain (IPR001242) and is shared by C- and E-domains. The Down-Seq region is specific to the enzymatic activity of the domain. Amino-acid signatures (represented as sequence logos) previously described for complete C-and E-domains have been restricted to the Down-Seq region and amplified thanks to additional sequences. Moreover a new Down-Seq signature has been found for Ct-domains found in fungi and responsible for terminal cyclization of the peptides. The identification of these signatures has been included in a workflow named Florine, aimed to predict nonribosomal peptides from NRPS sequence analyses. In some cases, the prediction of isomery is guided by genus-specific rules. Florine was used on a Pseudomonas genome to allow the determination of the type of pyoverdin produced, the update of syringafactin structure and the identification of novel putative products. [less ▲]Detailed reference viewed: 23 (1 ULg)
Redefining the PF06864 Pfam family based on Burkholderia pseudomallei PilO2(Bp) S-SAD crystal structure.
Lassaux, Patricia ; ; et al
in PloS one (2014), 9(4), 94981
Type IV pili are surface-exposed filaments and bacterial virulence factors, represented by the Tfpa and Tfpb types, which assemble via specific machineries. The Tfpb group is further divided into seven ... [more ▼]
Type IV pili are surface-exposed filaments and bacterial virulence factors, represented by the Tfpa and Tfpb types, which assemble via specific machineries. The Tfpb group is further divided into seven variants, linked to heterogeneity in the assembly machineries. Here we focus on PilO2(Bp), a protein component of the Tfpb R64 thin pilus variant assembly machinery from the pathogen Burkholderia pseudomallei. PilO2(Bp) belongs to the PF06864 Pfam family, for which an improved definition is presented based on newly derived Hidden Markov Model (HMM) profiles. The 3D structure of the N-terminal domain of PilO2(Bp) (N-PilO2(Bp)), here reported, is the first structural representative of the PF06864 family. N-PilO2(Bp) presents an actin-like ATPase fold that is shown to be present in BfpC, a different variant assembly protein; the new HMM profiles classify BfpC as a PF06864 member. Our results provide structural insight into the PF06864 family and on the Type IV pili assembly machinery. [less ▲]Detailed reference viewed: 25 (4 ULg)
Cell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour.
Blacher, Silvia ; Erpicum, Charlotte ; et al
in PLoS ONE (2014), 9(5), 97019
The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion ... [more ▼]
The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion, observed through optical microscopy, is measured. The present study proposes the spatial distribution of migrated cells as a new descriptor of the (lymph) angiogenic response. The utility of this novel method rests with its capacity to locally characterise spheroid structure, allowing not only the investigation of single and collective cell invasion but also the evolution of the spheroid core itself. Moreover, the proposed method can be applied to 2D-projected spheroid images obtained by optical microscopy, as well as to 3D images acquired by confocal microscopy. To validate the proposed methodology, endothelial cell invasion was evaluated under different experimental conditions. The results were compared with widely used global parameters. The comparison shows that our method prevents local spheroid modifications from being overlooked and leading to the possible misinterpretation of results. [less ▲]Detailed reference viewed: 41 (6 ULg)
Schmallenberg Virus Circulation in Culicoides in Belgium in 2012: Field Validation of a Real Time RT-PCR Approach to Assess Virus Replication and Dissemination in Midges
; ; et al
in PLoS ONE (2014), 9(1),Detailed reference viewed: 25 (1 ULg)
Continuous stroke volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments.
; ; et al
in PloS one (2014), 9(7), 102476
INTRODUCTION: Accurate, continuous, left ventricular stroke volume (SV) measurements can convey large amounts of information about patient hemodynamic status and response to therapy. However, direct ... [more ▼]
INTRODUCTION: Accurate, continuous, left ventricular stroke volume (SV) measurements can convey large amounts of information about patient hemodynamic status and response to therapy. However, direct measurements are highly invasive in clinical practice, and current procedures for estimating SV require specialized devices and significant approximation. METHOD: This study investigates the accuracy of a three element Windkessel model combined with an aortic pressure waveform to estimate SV. Aortic pressure is separated into two components capturing; 1) resistance and compliance, 2) characteristic impedance. This separation provides model-element relationships enabling SV to be estimated while requiring only one of the three element values to be known or estimated. Beat-to-beat SV estimation was performed using population-representative optimal values for each model element. This method was validated using measured SV data from porcine experiments (N = 3 female Pietrain pigs, 29-37 kg) in which both ventricular volume and aortic pressure waveforms were measured simultaneously. RESULTS: The median difference between measured SV from left ventricle (LV) output and estimated SV was 0.6 ml with a 90% range (5th-95th percentile) -12.4 ml-14.3 ml. During periods when changes in SV were induced, cross correlations in between estimated and measured SV were above R = 0.65 for all cases. CONCLUSION: The method presented demonstrates that the magnitude and trends of SV can be accurately estimated from pressure waveforms alone, without the need for identification of complex physiological metrics where strength of correlations may vary significantly from patient to patient. [less ▲]Detailed reference viewed: 10 (0 ULg)
Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.
Maertens, Ludovic ; Erpicum, Charlotte ; Detry, Benoît et al
in PLoS ONE (2014), 9(9), 106976
It is now well accepted that multipotent Bone-Marrow Mesenchymal Stem Cells (BM-MSC) contribute to cancer progression through several mechanisms including angiogenesis. However, their involvement during ... [more ▼]
It is now well accepted that multipotent Bone-Marrow Mesenchymal Stem Cells (BM-MSC) contribute to cancer progression through several mechanisms including angiogenesis. However, their involvement during the lymphangiogenic process is poorly described. Using BM-MSC isolated from mice of two different backgrounds, we demonstrate a paracrine lymphangiogenic action of BM-MSC both in vivo and in vitro. Co-injection of BM-MSC and tumor cells in mice increased the in vivo tumor growth and intratumoral lymphatic vessel density. In addition, BM-MSC or their conditioned medium stimulated the recruitment of lymphatic vessels in vivo in an ear sponge assay, and ex vivo in the lymphatic ring assay (LRA). In vitro, MSC conditioned medium also increased the proliferation rate and the migration of both primary lymphatic endothelial cells (LEC) and an immortalized lymphatic endothelial cell line. Mechanistically, these pro-lymphangiogenic effects relied on the secretion of Vascular Endothelial Growth Factor (VEGF)-A by BM-MSC that activates VEGF Receptor (VEGFR)-2 pathway on LEC. Indeed, the trapping of VEGF-A in MSC conditioned medium by soluble VEGF Receptors (sVEGFR)-1, -2 or the inhibition of VEGFR-2 activity by a specific inhibitor (ZM 323881) both decreased LEC proliferation, migration and the phosphorylation of their main downstream target ERK1/2. This study provides direct unprecedented evidence for a paracrine lymphangiogenic action of BM-MSC via the production of VEGF-A which acts on LEC VEGFR-2. [less ▲]Detailed reference viewed: 39 (7 ULg)
A New Look at Ichthyosaur Long Bone Microanatomy and Histology: Implications for Their Adaptation to an Aquatic Life
; ; et al
in PLoS ONE (2014), 9(4), 95637
Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades ... [more ▼]
Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades. Data concerning their bone microanatomical and histological features are rather limited and suggest that ichthyosaurs display a spongious, "osteoporotic-like" bone inner structure, like extant cetaceans. However, some taxa exhibit peculiar features, suggesting that the analysis of the microanatomical and histological characteristics of various ichthyosaur long bones should match the anatomical diversity and provide information about their diverse locomotor abilities and physiology. Methodology/Principal Findings The material analyzed for this study essentially consists of mid-diaphyseal transverse sections from stylopod bones of various ichthyosaurs and of a few microtomographic (both conventional and synchrotron) data. The present contribution discusses the histological and microanatomical variation observed within ichthyosaurs and the peculiarities of some taxa (Mixosaurus, Pessopteryx). Four microanatomical types are described. If Mixosaurus sections differ from those of the other taxa analyzed, the other microanatomical types, characterized by the relative proportion of compact and loose spongiosa of periosteal and endochondral origin respectively, seem to rather especially illustrate variation along the diaphysis in taxa with similar microanatomical features. Our analysis also reveals that primary bone in all the ichthyosaur taxa sampled (to the possible exception of Mixosaurus) is spongy in origin, that cyclical growth is a common pattern among ichthyosaurs, and confirms the previous assumptions of high growth rates in ichthyosaurs. Conclusions/Significance The occurrence of two types of remodelling patterns along the diaphysis, characterized by bone mass decrease and increase respectively is described for the first time. It raises questions about the definition of the osseous microanatomical specializations bone mass increase and osteoporosis, notably based on the processes involved, and reveals the difficulty in determining the true occurrence of these osseous specializations in ichthyosaurs. [less ▲]Detailed reference viewed: 27 (1 ULg)
Effects of adenosine on lymphangiogenesis.
Lenoir, Bénédicte ; ; Blacher, Silvia et al
in PloS one (2014), 9(3), 92715
BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood ... [more ▼]
BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis. METHODS: Lymphatic endothelial cells (HMVEC-dLy) were cultured in presence of adenosine and their proliferation, migration and tube formation was assessed. Gelatin sponges embedded with the stable analogue of adenosine 2-chloro adenosine were implanted in mice ear and lymphangiogenesis was quantified. Mice were intravenously injected with adenoviruses containing expression vector for 5'-endonucleotidase, which plays a major role in the formation of adenosine. RESULTS: In vitro, we observed that adenosine decreased the proliferation of lymphatic endothelial cells, their migration and tube formation. However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of lymphangiogenesis (2.5-fold, p<0.001). Adenovirus-mediated over-expression of cytosolic 5'-nucleotidase IA stimulated lymphangiogenesis and the recruitment of macrophages in mouse liver. Proliferation of lymphatic endothelial cells was enhanced (2-fold, p<0.001) when incubated in the presence of conditioned medium from murine macrophages. CONCLUSION: We have shown that adenosine stimulates lymphangiogenesis in vivo, presumably through a macrophage-mediated mechanism. This observation suggests that blockade of adenosine receptors may help in anti-cancer therapies. [less ▲]Detailed reference viewed: 54 (3 ULg)
Common neural substrates for ordinal representation in short-term memory, numerical and alphabetical cognition
Attout, Lucie ; ; Salmon, Eric et al
in PLoS ONE (2014), 9Detailed reference viewed: 34 (5 ULg)
What is the Ability Emotional Intelligence Test (MSCEIT) good for? An evaluation using item response theory.
; ; et al
in PloS one (2014), 9(6), 98827
The ability approach has been indicated as promising for advancing research in emotional intelligence (EI). However, there is scarcity of tests measuring EI as a form of intelligence. The Mayer Salovey ... [more ▼]
The ability approach has been indicated as promising for advancing research in emotional intelligence (EI). However, there is scarcity of tests measuring EI as a form of intelligence. The Mayer Salovey Caruso Emotional Intelligence Test, or MSCEIT, is among the few available and the most widespread measure of EI as an ability. This implies that conclusions about the value of EI as a meaningful construct and about its utility in predicting various outcomes mainly rely on the properties of this test. We tested whether individuals who have the highest probability of choosing the most correct response on any item of the test are also those who have the strongest EI ability. Results showed that this is not the case for most items: The answer indicated by experts as the most correct in several cases was not associated with the highest ability; furthermore, items appeared too easy to challenge individuals high in EI. Overall results suggest that the MSCEIT is best suited to discriminate persons at the low end of the trait. Results are discussed in light of applied and theoretical considerations. [less ▲]Detailed reference viewed: 57 (4 ULg)
How Does Pollen Chemistry Impact Development and Feeding Behaviour of Polylectic Bees?
Vanderplanck, Maryse ; ; et al
in PLoS ONE (2014)
Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of ... [more ▼]
Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of host plants, polylectic bees, such as bumblebees, collect pollen from many families of plants. These polylectic species contend with interspecific variability in essential nutrients of their host-plants but we have only a limited understanding of the way in which chemicals and chemical combinations influence bee development and feeding behaviour. In this paper, we investigated five different pollen diets (Calluna vulgaris, Cistus sp., Cytisus scoparius, Salix caprea and Sorbus aucuparia) to determine how their chemical content affected bumblebee colony development and pollen/syrup collection. Three compounds were used to characterise pollen content: polypeptides, amino acids and sterols. Several parameters were used to determine the impact of diet on micro-colonies: (i) Number and weight of larvae (total and mean weight of larvae), (ii) weight of pollen collected, (iii) pollen efficacy (total weight of larvae divided by weight of the pollen collected) and (iv) syrup collection. Our results show that pollen collection is similar regardless of chemical variation in pollen diet while syrup collection is variable. Micro- colonies fed on S. aucuparia and C. scoparius pollen produced larger larvae (i.e. better mates and winter survivors) and fed less on nectar compared to the other diets. Pollen from both of these species contains 24-methylenecholesterol and high concentrations of polypeptides/total amino acids. This pollen nutritional ''theme'' seems therefore to promote worker reproduction in B. terrestris micro-colonies and could be linked to high fitness for queenright colonies. As workers are able to selectively forage on pollen of high chemical quality, plants may be evolutionarily selected for their pollen content, which might attract and increase the degree of fidelity of generalist pollinators, such as bumblebees. [less ▲]
Effects of visual cortex activation on the nociceptive blink reflex in healthy subjects.
; ; MAGIS, Delphine et al
in PloS one (2014), 9(6), 100198
Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not ... [more ▼]
Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not known. To address this issue in healthy human subjects we modulated differentially visual cortex activity by repetitive transcranial magnetic stimulation (rTMS) or flash light stimulation, and studied the effect on supraorbital pain thresholds and the nociceptive-specific blink reflex (nBR). Low frequency rTMS that inhibits the underlying cortex, significantly decreased pain thresholds, increased the 1st nBR block ipsi- and contralaterally and potentiated habituation contralaterally. After high frequency or sham rTMS over the visual cortex, and rMS over the right greater occipital nerve we found no significant change. By contrast, excitatory flash light stimulation increased pain thresholds, decreased the 1st nBR block of ipsi- and contralaterally and increased habituation contralaterally. Our data demonstrate in healthy subjects a functional relation between the visual cortex and the trigeminal nociceptive system, as assessed by the nociceptive blink reflex. The results argue in favour of a top-down inhibitory pathway from the visual areas to trigemino-cervical nociceptors. We postulate that in normal conditions this visuo-trigeminal inhibitory pathway may avoid disturbance of vision by too frequent blinking and that hypoactivity of the visual cortex for pathological reasons may promote headache and photophobia. [less ▲]Detailed reference viewed: 32 (2 ULg)
The Dimethylsulfide Cycle in the Eutrophied Southern North Sea: A Model Study Integrating Phytoplankton and Bacterial Processes
; Borges, Alberto ; Speeckaert, Gaëlle et al
in Plos One (2014), 9(1)(e85862 DOI: 10.1371/journal.pone.0085862),
We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical ... [more ▼]
We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical processes (including DMS air-sea exchange). This module was integrated in the MIRO ecological model and applied in a 0D frame in the Southern North Sea (SNS). The DMS(P) module is built on parameterizations derived from available knowledge on DMS(P) sources, transformations and sinks, and provides an explicit representation of bacterial activity in contrast to most of existing models that only include phytoplankton process (and abiotic transformations). The model is tested in a highly productive coastal ecosystem (the Belgian coastal zone, BCZ) dominated by diatoms and the Haptophyceae Phaeocystis, respectively low and high DMSP producers. On an annual basis, the particulate DMSP (DMSPp) production simulated in 1989 is mainly related to Phaeocystis colonies (78%) rather than diatoms (13%) and nanoflagellates (9%). Accordingly, sensitivity analysis shows that the model responds more to changes in the sulfur:carbon (S:C) quota and lyase yield of Phaeocystis. DMS originates equally from phytoplankton and bacterial DMSP-lyase activity and only 3% of the DMS is emitted to the atmosphere. Model analysis demonstrates the sensitivity of DMS emission towards the atmosphere to the description and parameterization of biological processes emphasizing the need of adequately representing in models both phytoplankton and bacterial processes affecting DMS(P) dynamics. This is particularly important in eutrophied coastal environments such as the SNS dominated by high non-diatom blooms and where empirical models developed from data-sets biased towards open ocean conditions do not satisfactorily predict the timing and amplitude of the DMS seasonal cycle. In order to predict future feedbacks of DMS emissions on climate, it is needed to account for hotspots of DMS emissions from coastal environments that, if eutrophied, are dominated not only by diatoms. [less ▲]Detailed reference viewed: 27 (5 ULg)
The genetic legacy of multiple beaver reintroductions in central Europe
; ; et al
in PLoS ONE (2014), 9(5),
The comeback of the Eurasian beaver (Castor fiber) throughout western and central Europe is considered a major conservation success. Traditionally, several subspecies are recognised by morphology and ... [more ▼]
The comeback of the Eurasian beaver (Castor fiber) throughout western and central Europe is considered a major conservation success. Traditionally, several subspecies are recognised by morphology and mitochondrial haplotype, each linked to a relict population. During various reintroduction programs in the 20th century, beavers from multiple source localities were released and now form viable populations. These programs differed in their reintroduction strategies, i.e., using pure subspecies vs. mixed source populations. This inhomogeneity in management actions generated ongoing debates regarding the origin of present beaver populations and appropriate management plans for the future. By sequencing of the mitochondrial control region and microsatellite genotyping of 235 beaver individuals from five selected regions in Germany, Switzerland, Luxembourg, and Belgium we show that beavers from at least four source origins currently form admixed, genetically diverse populations that spread across the study region. While regional occurrences of invasive North American beavers (n = 20) were found, all but one C. fiber bore the mitochondrial haplotype of the autochthonous western Evolutionary Significant Unit (ESU). Considering this, as well as the viability of admixed populations and the fact that the fusion of different lineages is already progressing in all studied regions, we argue that admixture between different beaver source populations should be generally accepted. © 2014 Frosch et al. [less ▲]Detailed reference viewed: 16 (1 ULg)
First Clarkforkian equivalent land mammal age in the latest Paleocene basal Sparnacian facies of Europe: Fauna, flora, paleoenvironment and (bio)stratigraphy
; ; et al
in PLoS ONE (2014), 9(1),
The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age ... [more ▼]
The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age, that has yielded rodents and carnivorans, is the only exception to this rule. However, until now no pre-PETM localities have yielded modern mammals in Europe or Asia. We report the first Clarkforkian equivalent Land Mammal Age in the latest Paleocene deposits of the basal Sparnacian facies at Rivecourt, in the north-central part of the Paris Basin. The new terrestrial vertebrate and macroflora assemblages are analyzed through a multidisciplinary study including sedimentologic, stratigraphic, isotopic, and palynological aspects in order to reconstruct the paleoenvironment and to evaluate biochronologic and paleogeographic implications. The mammals are moderately diverse and not abundant, contrary to turtles and champsosaurs. The macroflora is exceptional in preservation and diversity with numerous angiosperms represented by flowers, fruits, seeds and wood preserved as lignite material, revealing an abundance of Arecaceae, Betulaceae, Icacinaceae, Menispermaceae, Vitaceae and probably Cornaceae. Results indicate a Late Paleocene age based on carbon isotope data, palynology and vertebrate occurrences such as the choristoderan Champsosaurus, the arctocyonid Arctocyon , and the plesiadapid Plesiadapis tricuspidens. However, several mammal species compare better with the earliest Eocene. Among these, the particular louisinid Teilhardimys musculus, also recorded from the latest Paleocene of the Spanish Pyrenees, suggests a younger age than the typical MP6 reference level. Nevertheless, the most important aspect of the Rivecourt fauna is the presence of dental remains of a rodent and a "miacid" carnivoran, attesting to the presence of two modern mammalian orders in the latest Paleocene of Europe. Interestingly, these two groups are also the only modern groups recorded from the latest Paleocene of North America, making Rivecourt the first direct equivalent to the Clarkforkian Land Mammal Age outside of North America. © 2014 Smith et al. [less ▲]Detailed reference viewed: 14 (4 ULg)


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This item from Best Kept Secrets is now SOLD.
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Vintage Jewelry Presentation Box Ester M. Barlow Lawrence, Mass
Vintage blue 2 3/4" X 1 1/2" X 7/8" domed top hinged box with gold border. Box is in good vintage condition with original beige velvet liner on the inside bottom. The inside top original silk/satin lining is stamped "Ester M. Barlow Jeweler 208 Essex St. Lawrence Mass. Inside shows very light age appropriate light yellowing, outside shows very light surface wear.. The box is impressed on the bottom "Barrington BOXES MADE IN USA. I'll let the pictures tell the rest of the story.
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Wednesday 16th March is bonus day on globalgiving.com! Donate as soon as you can that day to take advantage of this fantastic offer, which will make your donation go further. Global Giving pledge to match 30% of your donation up to $1,000 per donor until they have matched $75,000 (if you live in the USA). This means that if you donate $31 on Wednesday, your donation will be increased to just over $40.
Elena, our project leader in St Petersburg, reports on how the young people are gradually growing in confidence, thanks to your help.
"Teenagers in children's homes feel very stable and untroubled. They are still relying on the social teachers to look after them while they study at college or technical college, where they will live in orphan's centre, and independent life is still far off for them. But the young people in the final year at college are in a completely different state of panic and confusion. Until this point they haven't thought of asking for help, because everything seemed to happen "of its own accord". Many of the young people find it very difficult to work out what they feel and what they need, and the future is unknown and fearful to them. Understanding "what stage in life I am at" has become an important theme in the training sessions.
Boris said, "When I imagine my life, I can't see what is next to me and where my place is. It's frightening to think about what's next".
Alexander: " I have several paths, but they are all mixed up inside me when I have to make a choice, because no-one is going to choose for me. "
In January we held three meetings and led one outing with 12 young people from the top classes in children's homes or who have recently left the orphanage. Two volunteer families from our club for parents who grew up in orphanages also took part.
We invited our young people to a festival of kind art called "A Happy Postcard. From heart to heart – sent from person to person" in order to support our young people and to show them that their situation in life is dependent on choices and decisions rather than on the punishment of fate, and that you can learn from this as an adult. The young people took part in open master classes with professional artists, were taken round the gallery of contemporary art, and open exhibitions, in which the young people saw art work by children from other children's homes amongst creative work of artists and photographers from around the world.
It was a revelation to them that "complete strangers can be kind to me", and that, "I can do something with people I don't know". Natasha said, "I didn't expect that someone from a children's home could draw as well as a child from a family"."
Please help us continue to support these fearful orphans, so that they can look forward to a positive future.
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating.
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This conference will address the most important issues of a dangerous and exciting 21st century landscape for investors, business leaders and private citizens. It will address the threats of terrorism, political instability, mass migration, disease, energy shortage and extreme weather. At the same time, it will explore the opportunities presented by emerging markets, developments in technology and healthcare, and the globalisation of trade and communication. It will bring together a remarkable range of practitioners and expert commentators in all these fields.
The conference is a unique opportunity to put questions to - and exchange ideas with - some of the most influential voices in politics, business, environmental and health science, strategic consultancy and the media.
The Spectator has been a buzzing centre of British public debate since 1828. These days, that debate takes the form of a programme of high-profile live events as well as in weekly print and in our online Coffee House forum. Spectator Business, launched in 2008, has established a reputation for bringing to financial and economic analysis all the intelligence and wit that readers expect from a Spectator title. Risk and opportunity in a dangerous world will combine all those qualities with a line-up of world-class speakers, from Sir Malcolm Rifkind to Lord Guthrie, Rory Stewart and Lord Levy.
Mon, 19/12/2016 - 09:35
Tue, 10/01/2017 - 12:28
Thu, 22/12/2016 - 10:55
Tue, 06/12/2016 - 10:17
Mon, 12/12/2016 - 10:24
Tue, 29/11/2016 - 13:22
Thu, 10/11/2016 - 12:39


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320 Heinlein Strasse, Frankenmuth, MI 48734
Located in Frankenmuth, MI. Inquire to find out about the building and its availability.
Sample Spaces to Show Approximate Pricing
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with one of our brokers to get more information and schedule a visit.
the space and envision it as your next office.
a lease you can feel good about.
Get the space your business deserves.
Learn about our services
See how we partner with you to provide technology and expertise to get your team into a space made for your future


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- Description
The Altura Women's Night Vision Long Sleeve Jersey is designed to keep you visible on the roads when riding in fair conditions. With a women's specific fit and lots of critically positioned reflective detail and soft-touch high wicking thermal fabric, this jersey will help keep you comfortable as well as ensuring you are seen. Perfect for commuters as well as leisure and road riders.
Buy a Altura Womens Night Vision Long Sleeve Jersey - Raspberry online today
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Review "Altura Womens Night Vision Long Sleeve Jersey - Raspberry"
*Price based on 0% deposit and 36 monthly installments | ** On orders over £50.00. Due to restrictions from the manufacturer we are unable to ship Trek, Whyte, Cervelo, Focus and Wilier bikes. Please contact us for more information and advice. Excludes Highlands and Isles which will be quoted separately. We do our very best to ensure product accuracy but from time to time specification and product images may be subject to change. Please contact us for any product queries you may have.
PLEASE NOTE: discounted prices are not available on purchases using 0% finance or a Cycle to Work Scheme. Discounted prices are not available in conjunction with any other promotion.


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Theme features
Mosaic-style layout
Feature multiple products, collections, or promotions in a mosaic-style grid on your home page.
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- Description
Quick Overview
If excellent coverage and high colour pay-off is what gets you going, you will absolutely love our new Sugar Matte As Hell Lip Crayon that is available in 4 gorgeous shades to suit your taste & your ever-changing mood! Super long-lasting and highly pigmented so you don't have to worry about constant re-application, this must-have lip crayon has a soft texture with a silky matte finish.
- Feeling confident & sexy. Flaunt a classic red pout with the Scarlett O' Hara shade - that's guaranteed to make heads turn
- Want to go bare-faced with a pop of color. Say hello to Mary Poppins! It is an eye-catching Fuchsia shade that can never go unnoticed
- A classic shade that can instantly add a touch of mystery to your entire look, Poison Ivy is hot on the runway and a must-try shade for those who love to experiment
- Want to pull off dramatic eyes and come out as a winner. Holly Golightly is the way to go! This peachy shade goes well with elaborate eye make-up & can also be used every day for a natural look
- You will also get a sharpener free with this product
The Sugar Matte As Hell Lip Crayon has a creamy consistency that eventually settles in to a matte finish. With stunning shades that don't fail to impress, it provides maximum coverage with the right amount of color. Sugar Matte Lipstick is dermatologically tested & approved and 100% safe for your skin.
The Sugar Matte As Hell Lip Crayon is available in 4 attractive shades viz., Scarlett O' Hara (Red), Mary Poppins (Fuchsia), Poison Ivy (Wine) & Holly Golightly (Nude). Its wax-based formulation does not contain mineral oil, parabens, paraffin, phenoxyethanols, volatile cyclomethicones (D4, D5, D6) and animal derived ingredients.
Explore our entire range of Lipstick Shades available here.
Expiry Date : April 2019
All our products are far from expiry, and procured directly from the brand/authorized resellers of the brand.
Dimethicone, Diisostearyl Malate, Synthetic Wax, Distarch Phosphate, Polybutene, Dimethicone/Vinyl Dimethicone Crosspolymer, Caprylyl Methicone, Dimethylimidazolidinone Rice Starch, Glyceryl Caprylate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Silica, Isoceteth - 10 May Contain: C.I. Nos. 45410, 15850, 19140
How to use product
Exfoliate your lips & apply the Sugar Matte Crayon Lipstick just the way you would with any other lipstick. Blot & reapply.
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By Bidisha Das
This is my first ever crayon shade and I am satisfied.
Posted on 1/16/2017
By Anjana
I purchased the shade Mary Poppins. At first i was quite skeptical about the product..but to my surprise it met my expectations next to the other high-end lipsticks/lip crayons . All the shades are absolutely amazing and worth a try.
Posted on 1/16/2017
By Sweta Shah
Just the perfect red! Stays on for entire day!
Posted on 1/14/2017
By Kanika Oberoi
Okay so this is my first lipstick ever and I beyond happy to have bought this. Application is easy, stays for a good 5 hours, doesn't Transfer too much, comes in a really cute packaging. I'll be getting these in the shades Scarlett O'Hara and Mary Poppins too!
Posted on 1/11/2017
By megha
I bought this one for a friend and she is in love with the color. It's bright and bold , you can wear it to office or an evening out with your girlfriend's. And it stays for hours. You should try it once.
Posted on 1/11/2017
By neha jaiswal
it's amazing lipstick..i'm so happy to brought me..
Posted on 1/7/2017
By Idikaa Gupte
best nude shade I have ever encountered!!!glides on smoothly and stays for 6 hours!!!! love it
Posted on 1/4/2017
By Deepika
This is the best red shade.its complete matte & stays forever unless i remove wid makeup remover.like i eat,sleep & its still there.it instantly brights up the face. texture is very light & doesnt dry the lips
Posted on 1/4/2017
By Dolly
It is a bright amazing colour,I love this shade.It is gives a true matte finish when applied and stays for about 4-5hours.
Posted on 1/3/2017
By Ritika
This is the second time that I have purchased this lipshade and I love it.. The color is perfect for everyday use and so matte. This is my go-to nude shade. I only think that the texture could improve a little bit as it gets patchy in a few hours. Of this range, Mary Poppins has the best texture, application and is highly pigmented.
Posted on 1/2/2017
Ask Nykaa (0)
Have a question on this product? Write a question and earn 100 reward points.Q.Which shade is suitable for fairer side of wheatish skintone? What should I choose between rose dawson and holly golightly ?Question by: Akanksha on Nov 22, 2016 12:56:00 PMA.Thank you for writing to us.
Both shade will suit the skin tone you mentioned. You can also use the 'Try it on' option to see which shade suits better.
Hope that you find the solution to your advantage.
Thank you for shopping at Nykaa!
Team NykaaAnswer by: Team Nykaa on Dec 3, 2016 12:13:59 PMQ.Does holly golightly show up on pigmented lips??Question by: Ritika Mishra on Oct 10, 2016 4:01:00 PMQ.When the visible product finishes, is it supposed to be sharpened? If yes, how?
Question by: Radhika Singhal on Sep 13, 2016 8:52:00 PMQ.How is Rose Dawson for pigmented lips n wheatish tone?Question by: asha tiwari on Aug 29, 2016 2:53:00 PMQ.Is the sharpener included with the lip crayon?Question by: Barnadipti Debnath on Jun 14, 2016 11:16:00 PM


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Charles Carey
CBOT steps up war with Eurex
The Chicago Board of Trade (CBOT) will launch three electronically traded German debt futures contracts in what appears an escalation in the exchange's war with European rival Eurex. It has also reduced transaction fees for its customers that electronically...
CBOT lowers fees for European traders
The Chicago Board of Trade (CBOT), in an early effort to head off competition from Eurex, is to offer cheaper electronic access for European traders, the exchange announced.
CBOT chief again hits out at Eurex US
Chicago Board of Trade (CBOT) chairman Charles Carey urged the Commodity Futures Trading Commission to conduct a full and careful review of the application by Eurex to establish a US subsidiary yesterday. Carey's comments are the latest in an ongoing...


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I have a USB flash drive (shows up in device properties as "Generic Flash Disk USB Device") that is currently write protected. It was being used for ReadyBoost on Windows 7 64 bit.
Somehow it is now not able to be used for ReadyBoost and also is write protected.
There is NO read only switch on the device.
How can I make it writable again so I can use it once more for ReadyBoost on Windows 7 64 bit please?
Collapse -
Have you tried formatting it on another machine?
by robo_dev
Assuming that system restore is set so that it does not monitor that drive, and that it is set to 'optimize for quick removal', it should just work.
If it is still read-only on another PC or Linux system, then perhaps the device is damaged?
Note that some drives have a microscopic-size read-only switch or one hidden by a device cover.


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that blue is just beautiful <3
- 57 Posts. Joined 2/2013
- Location: South Texas
- Select All Posts By This User
that blue is just beautiful <3
wow...frank..u never seem to impress me...once again.. damn..that silver cable would look stupendously good on my full metal beyers mmx300
That can depend on the cable you have on order as most have already gone in to production. If anyone has a sleeved Poison or Viper, they are more then welcome to go for the new silver/blue sleeved cable, please let me know ASAP, there will be no extra charge.
Toxic Cables second year as a head-fi sponsor starts today.
May I request one-thing? , Please update headphone's cable information to your website. It's very hard to search information on this forums.
Just click on Frank's profile. All the information are there.
There is a reason why I don't buy cables from anyone else other than Frank after seeing his work versus others....simply stunning and always on the frontier of improving the product line for the customer. Keep up the nice work Frank, that is some crazy nice sleeving you're introducing.
Just click on Frank's profile. All the information are there.
Yes, I know this link. But it contain only cable's (model)name and price.
Didn't contain picture and description (like frank's post on this forum) right?
I'm normally not too big on looks but WOW that blue is gorgeous. I might have to prepare for intoxication.
Hi Frank. For sleeve color of Scorpion personally I don't like red but green is fine. Instead of red I would suggest violet which looks better and should match with most color of headphones.
Yes, I also like WHITE. I think all the neutral colors can easily match with colors of most headphones


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No sales found matching your criteria.
Try removing some filters on the left side of this page. Or you can increase your search distance.
YardSales.net is the fastest growing yard sale site, with 0 sale photos and 0 garage sales in Madison, Indiana. YardSales.net offers you the best list of Madison yard sales every week.
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The Worker Protection Standard (WPS)
PLEASE NOTE: The WPS rules have been revised and will go into effect January 2, 2017. Until then, you MUST comply with the current regulations. Watch our website for updated information. To view the new regulations, visit EPA's Webpage on the Revised Worker Protection Standard. CDA and CSU will be providing information via Webinars and Presentations. If you would like a presentation or to conduct a webinar, please contact Mike Rigirozzi at CDA (303) 869-9059 or CEPEP.
Watch the most recent webinar covering some of the important changes to WPS: Revisions to WPS 2016 (approximately 1 hour in length).
CURRENT REGULATIONS (until January 2, 2017)
Protecting Agricultural Workers and Handlers
The Worker Protection Standard (WPS) is an EPA-administered regulation. It aims to reduce the risk of pesticide poisonings among agricultural workers and pesticide handlers.
- The WPS offers protections to approximately 2.5 million agricultural workers (people involved in the production of agricultural plants) and pesticide handlers (people who mix, load, or apply pesticides) who work at over 600,000 agricultural establishments.
- These establishments include farms, nurseries, forests, and greenhouses.
- The WPS contains requirements for:
- pesticide safety training,
- notification of pesticide applications,
- use of personal protective equipment,
- restricted-entry intervals after pesticide application,
- decontamination supplies,
- and emergency medical assistance.
If you use pesticides in the course of your business as an employer of agricultural workers or pesticide handlers, learn how to comply with the WPS.
You can also use our site to learn more about worker training required to comply with WPS.
CEPEP has developed a photo novella on Spanish and English on preventing take-home exposure for pesticides residues. Please check it out and send us your comments, or if you want some for distribution, let us know how many you need.
For Employees — Para empleados
- Worker and Handler Bill of Rights
- Declaración de Derechos para Trabajadores y Manejadores
- How to Protect Your Family from Pesticides
- Cómo Proteger a Su Familia de los Pesticidas
- Reconocimiento y Manejo de los Envenenamientos Por Pesticidas, 5th Edición, por la EPA
- Otros Recursos en Español por la EPA


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About Homer
- About Facts and Figures Events & Activities City Calendar Library Events Recreation Events
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- Office of the Mayor City Council Commissions and Boards Advisory Planning Cannabis Advisory Economic Dev. Advisory Library Advisory Parks & Recreation Advisory Port & Harbor Advisory
- City Clerk's Office Agendas and Minutes Committees & Task Forces ADA Compliance Public Safety Building Review Standing Committees
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- How Do I?
Book Club - 'The Seamstress'
Calendar Date:
Tuesday, February 21, 2012 -
4:30pm to 6:30pm
Add to your calendar:
Tuesday, February 21, 4:30-6:30pm
February's pick is 'The Seamstress' by Frances De Pontes Peebles.
As seamstresses, the young sisters EmÍlia and Luzia dos Santos know how to cut, mend, and conceal — useful skills in the lawless backcountry of Brazil, where ruthless land barons feud with bands of outlaw cangaceiros, trapping innocent residents in the crossfire.
The Book Club meets regularly on the third Tuesday of each month in the Homer Public Library's Meeting Room. See you there!


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Below is a list of the best performing Russell 1,000 stocks since the July 2nd correction low. As shown, Hewitt Associates (HEW) is up the most with a 40% gain, followed by MBIA (NYSE:MBI) (26.56%), Anadarko (NYSE:APC) (24.01%), priceline.com (NASDAQ:PCLN) (22.37%), and Marshall & Ilsley (NYSE:MI) (22.37%). Hewitt and a few other stocks on the list are trading in overbought territory, but most are not. This shows just how oversold stocks were before we got this bounce.
click to enlarge


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Score! This item is XX% off.
Thermopolis LT 2-N-1 Neck Warmer
$ 22.00
Thermopolis LT 2-N-1 Neck Warmer
$ 22.00
- Description
- Shipping
This Thermopolis® LT reversible accessory is versatile enough to wear two ways and soft enough to provide superior warmth.
- Asics softest multi-weather brushed fabric
- Double layer construction for added thermal protection
- Pull down for ventilation
- Reversible for versatility
- Reflective detailing for visibility and added safety
US orders will ship via USPS and generally take between 1-2 weeks.


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Isadore Bernstein
Isadore Bernstein, a longtime resident of Gloversville, died on August 5, 2014, at the age of 96 in Miami, Florida, after a long, full life and just four weeks after the death of his beloved wife of 65 years, Jacquelyn, 88. An honest, good-hearted and gentle man, Iz was a loyal and devoted family man and friend. Humble by nature, he took great pleasure in the accomplishments of others.
Born in Albany, N.Y., on May 28, 1918, Iz grew up in Gloversville, NY, graduating from Gloversville High School in 1936. The first in his family to graduate from college, he received a B.S. in accounting from the School of Commerce, Accounts and Finance of New York University in 1941. He loved living in New York City – dividing his time between classes, Yankees games, and big-city adventures. From 1943 to 1946, Iz proudly served his country as a Master Sergeant in the U.S. Army Air Force. Stationed in India, he provided supplies to missions headed "over the hump" to China. After the war, he worked as an accountant in Providence, Rhode Island, returning to Gloversville to enter the family glove business, J.Bernstein's Sons, with his brother, Sam. They worked together for over 50 years; at Sam's death in 1995, Iz continued in the business until his retirement in 2000.
Iz was a lifelong member of Knesseth Israel Synagogue in Gloversville, where he was a board member, and was a longtime member of B'nai B'rith, and Kingsboro and Pine Brook golf clubs.
It is an understatement to say that Iz loved sports – whether playing, watching, or Monday morning quarterbacking, he immersed himself in the world of competitive sports on all levels and continued to play golf into his 90s. He had a great short game!
He and Jackie traveled all over the world and enjoyed winters in Florida. In 2009, they made Miami their home.
Iz is survived by his son, Ronald Bernstein of Miami; and daughter, Joan Bernstein of Bernardston, Mass.; his daughter-in-law, Eva Bernstein; and son-in-law, Barry Auskern; four adored grandchildren, Jesse Kommel-Bernstein, Lauren Bernstein, Jeremy Kommel-Bernstein and Talia Bernstein; two dear nieces, Johanna Cohen and Ellen Bildersee (Bob); nephews, great-nieces, nephews and great grand-nephews. He was predeceased by his parents, Rachel and Jacob Bernstein; and by his brother, Sam Bernstein. The Yankees, Knicks and Giants have lost one their biggest fans.
Military honors were presented at a memorial service on August 8, 2014, at the couple's home in Miami.
Contributions in Iz and Jackie's memory can be made to Knesseth Israel Synagogue or the charity of your choice.


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What We've Learned About Every Positional Unit so Far in Bengals' Preseason
What We've Learned About Every Positional Unit so Far in Bengals' Preseason
One week into the preseason and the Cincinnati Bengals face a lot of tough questions.
The injury bug bit the Bengals hard in Week 1. Starting left guard Travelle Wharton is done for the year, while Carlos Dunlap is likely to miss the season opener. With a number of other starters banged up, the Bengals are already preparing for the worst.
It's not all doom and gloom however, with the team's rookies and younger players putting on impressive displays in Week 1 as they compete for a roster spot.
The injuries may have forced the Bengals to look to their youth faster than they had hoped, but they have given us great insight into the both the good and bad realities of the 2012 Bengals roster.
Andy Dalton put in a confident if unimpressive display in the opening preseason game.
The second year QB's comments during camp foretold what we were to see on Friday night;
"It hasn't been perfect but that's what camp is for, trying to find the mistakes and correct them," Dalton said.
Dalton completed 4 of 9 pass attempts for 54 yards. The performance will be remembered for A.J. Green's dreadful endzone drop that robbed Dalton and the Bengals of a touchdown.
The main positive here for Bengals fans is that one year removed from a mauling at the hands of the Detroit Lions, Andy Dalton is playing with the confidence and intelligence of someone with twice his experience.
Bruce Gradkowski put in a characteristically scrappy yet competent performance on Friday night. He connected with Marvin Jones for two catches that will immediately boost the young receivers credibility going forward.
Zac Robinson has had a steady preseason thus far, and should see more extensive work throughout the rest of the preseason.
Running Backs
Bad news for rookie RB Dan Herron.
Cedric Peerman put in a dominant display on Friday, stating his case for the likely fourth and final spot at running back.
BenJarvus Green-Ellis, Bernard Scott and Brian Leonard figure to have their roster spots assured, while Peerman's heroics on special teams and ground and pound running style won him new fans on Friday night.
Green-Ellis had seven carries for 22 yards against the Jets. The Law Firm impressed in his short runout, making something of nothing on more than one occasion. He may not be a flashy presence in the backfield, but he gets positive yardage, consistently.
The fifth spot will go to Chris Pressley who has been unchallenged as the Bengals starting full back. Brian Leonard may see some time at FB but the job is well and truly Pressley's at this point.
One other name to consider is Aaron Brown. He has shown real potential in camp, but is it enough to overcome the numbers game when cuts begin?
Wide Receivers
The Bengals are well and truly stockpiled at WR.
Both Brandon Tate and Armon Binns had strong training camps, bolstered by matching performances in Week 1.
They remain neck and neck in the race for the No. 2 spot, while Marvin Jones threw his hat in the ring with a team-leading performance of his own.
Mohamed Sanu didn't get a chance to contribute in the opener which says more about the sheer volume of receivers on the Bengals roster than it does about his talent. Sanu should get a better opportunity to make an impression in Atlanta on Thursday.
Andrew Hawkins had a slow start against the Jets, but Jordan Shipley is a long way off challenging him for the job. Shipley surfaced in garbage time against the Jets which suggests he is some way off from starting, if he even makes the final roster.
Ryan Whalen looks to miss out on making the final roster, despite having one of the safest pairs of hands in the receiving corps. The smart money would be on a Luck-Whalen reunion in Indianapolis before long.
Tight Ends
Jermaine Gresham has been his own biggest critic this offseason;
"I'm very, very average, below average right now. I need to excel at things so I can be on the top-level tier with those guys. It's just that simple." said Gresham.
His performance on Friday did little to dismiss these comments, with the towering TE only pulling in one reception for 19 yards.
There is no reason to worry just yet, Gresham is still expected to be Andy Dalton's top target after Green in 2012, and he should start to show us why in the coming weeks.
Donald Lee and Orson Charles will duke it out for the back-up job beginning in Atlanta on Thursday. Lee brought veteran consistency when called upon in 2011, while Charles carries a boatload of promise.
Colin Cochart appears to be the weak link and has done little to suggest he will make the team thus far.
Offensive Line
Bengals fans and coaches have been holding their collective breath since the moment Travelle Wharton went down on Friday night.
With Wharton out for the year, the job falls to Clint Boling who appeared out as depth in 2011.
The good news is Boling has come on leaps and bounds since then, and had been pushing for playing time even before Wharton went down.
The real concern here is depth. Boling was intended as the back-up for right guard Kevin Zeitler with the capability of playing back-up to center Kyle Cook also.
Andre Smith has had a strong camp and looks set to take another step in 2012, while Andrew Whitworth is eager to bounce back from a disappointing 2011.
Defensive Line
Pat Sims could be on his way out in Cincinnati. An image of Sims sitting on a cooler watching his teammates practice has emerged from the Bengals practice field, and suggests that the back-up nose tackle is far from 100 percent. With rookie Brandon Thompson breathing down his neck and looking solid, Sims is likely to see the axe, and soon.
Geno Atkins hasn't missed a beat since his Pro Bowl 2011 season and looks to go from strength to strength in 2012.
DeQuin Evans has put to together an impressive offseason, and kicked off the preseason with three tackles and one QB pressure against the Jets. The Bengals seem high on Evans, but barring a showcase in the next three games, Evans is destined for the practice squad.
Devon Still manhandled the Jets offensive line at PBS, and displayed an impressive one-two punch of strength and speed.
Left end Carlos Dunlap suffered a significant knee-injury in the first quarter against the Jets. He is likely to miss the season opener in Baltimore, depending on how quickly he heals in the next week or so.
Former 2007 first-round pick Jamaal Anderson will step into his spot when the Bengals travel to Atlanta on Thursday.
The Bengals linebacker corps has grown significantly this offseason. This will prove difficult when it comes to cuts. The Bengals could justify keeping eight of these players due to the range of skills available to them.
Those unlikely to make the cut are: Dontay Moch, Emmanuel Lamur, Micah Johnson and Grant Hunter.
Moch has real potential and could be the aforementioned 'eighth' man in the lineup. He had a solid outing against the Jets, but his four game suspension and his failure to play consistently since his arrival could be his undoing.
Vontaze Burfict seemed to be just about everywhere on Friday night. He may not be polished, but Burfict has all the tools and believe it or not a great attitude to boot. The controversial UDFA has undergone a transformation this offseason and his place seems secure.
Dan Skuta and Roddrick Muckelroy have also impressed thus far, and give the Bengals some solid depth. Vincent Rey also figures to make the team backing-up Manny Lawson.
Defensive Backs
Reports out of Bengals camp this week suggest that both Jason Allen and Nate Clements could see time in the strong safety role.
With Taylor Mays recovering from a concussion, the Bengals have been assessing their options were he to go down during the regular season.
By starting Clements at SS, the Bengals would be able to go with Terence Newman and Leon Hall at corner with Reggie Nelson at FS. That's a pretty strong back four.
It tells us that while the Bengals have replaced Chris Crocker with Taylor Mays, the inexperience and youth of those behind him remains a weak point in the secondary.
From a numbers standpoint its hard to see George Iloka making the final 53 despite having significant potential. If he does creep into the final lineup it could mean the axe for Brandon Ghee.
Leon Hall has looked 100 percent and shows no signs of rust. The veteran CB was sorely missed in 2011, and gives Mike Zimmer's secondary an immediate boost with his return.
First round pick Dre Kirkpatrick continues to recover from his knee injury, but is unlikely to see the field any time soon. The concern for Kirkpatrick is that he has fallen so far behind and practiced only sparingly with the defense. This raises the question that even when he does return, how long is it going to take him to simply catch up with all that he has missed?
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Pirates on the Hudson Halloween Yacht Cruise
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for Pirates on the Hudson Yacht Cruise was Friday October 25, 2013 / 8:00pm (Boarding Begins at 7:30pm).
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Celebrate Earth Day at the New York Green Festival
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Featured review from Dustin Cross
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This is the second time we had been on this boat. Last year the event was much more organized. We arrived to the boat this year and found that we had been moved from the Half Moon Yacht to the Jewel yacht because they hadn't sold enough tickets. We never received an email letting us know this and only one person at the dock had this information so unfortunately we spent about 5 minutes searching for the boat.
When we boarded the boat about 15 minutes before setting sail we were welcomed by about 35 people in really sad costumes sitting around an undecorated dance floor. But the party must go on so we bellied up to the bar to grab some "Halloween Spirit." We ordered two vodka sodas and a corona. The vodka sodas were delivered in what can only be described as a plastic Dixie cup, picture going to the dentist and having him make you a drink in the spit cup. The total for these 3 drinks came to $25. I live in midtown Manhattan and could but 6 drinks for that total.
We then made our way to the buffet which was free last year. This year it was $10 a plate and $2 per empanada. Needless to say no one was eating it.
Before the boat set sail we got our selves back on the dock, grabbed cab and went to our local bar for a much more fun and entertaining evening.
Without a doubt we will not be back next year. It is truly a shame when a great even gets in the hands of the wrong greedy people.
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very nice. the weather was great, people was very friendly. easy to get to the venue.


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A lot of you know that I have been exploring the world of "raw foods" over the past many months, making myself loads of green smoothies, experimenting with new raw recipes and reading a lot about the philosphy behind the movement. And I guess I even scared my mom, who called me and gently suggested that I might be an orthorexic. So I just wanted to take a moment and clear the air and also let everyone know my current thoughts on the raw food thing.
I am not a "raw foodist" but I do try to eat a lot of raw veggies, fruits and nuts. That does not mean that I also do not eat a ton of cooked veggies. It's all good!
So why this fixation on raw? Well, it turns out that if you follow Dr. Fuhrman's advice on becoming a Nutrarian (1 pound of raw veggies and 1 pound of cooked veggies every day--not nearly as difficult as it sounds) you might start out by consuming a lot of green salads. And that can get a little boring after a while. It's not nearly as much fun as testing out all of the wonderful cooked recipes in his books, on the internet and in cookbooks, that's for sure.
That's where the world of raw food stepped in to save the day. It's full of millions of amazing recipes--all with raw fruits and vegetables. It made being a Nutrarian all the more fun and exciting, but it didn't turn me into a radical.
If you are interested in what Dr. Fuhrman has to say about the raw vs. cooked debate, check out the following links:


text: 000 WGUS46 KMFR 190422 FLWMFR BULLETIN - IMMEDIATE BROADCAST REQUESTED FLOOD WARNING NATIONAL WEATHER SERVICE MEDFORD OR 822 PM PST WED JAN 18 2017 ...The National Weather Service in Medford has issued a Flood Warning for the following rivers in Oregon... Rogue River near Agness affecting Curry County... PRECAUTIONARY/PREPAREDNESS ACTIONS... Do not drive through flooded areas or roads. The water may be too deep or there may be unseen damage to the roadway. For the latest river stages and forecasts, visit our web page at www.weather.gov/medford or listen to noaa weather radio. && ORC015-191022- /O.NEW.KMFR.FL.W.0007.170119T1007Z-170120T0805Z/ /AGNO3.1.ER.170119T1007Z.170119T1200Z.170119T2005Z.NO/ 822 PM PST WED JAN 18 2017 The National Weather Service in Medford has issued a * Flood Warning for the Rogue River near Agness. * FROM LATE TONIGHT TO LATE THURSDAY NIGHT. * At 7:30 PM Wednesday the stage was 13.1 feet. * Flood Stage is 17.0 feet. * Minor flooding is forecast. * Forecast...The river is expected ti rise above flood stage late tonight...cresting near 18 feet early Thursday morning...then subsiding below flood stage late Thursday morning. * Impact...At 17.0 feet...River rises to this stage or above may affect recreation interests along the Rogue River at and below Agness, Oregon. Sudden river rises of a few feet may also affect home and business owners with boat docks on the river. * Flood History...This crest compares to a previous crest of 17.7 feet on Dec 14 2015. && LAT...LON 4274 12390 4246 12442 4237 12442 4261 12385 4274 12375 $$ Sven


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Market research firm IDC reports that 3Q05 data storage equipment sales to businesses were quite strong -- data was recapped in the Wall St. Journal (sub. req.) -- key numbers by sector:
Sales of hard-disk-based storage gear, the core machines used by companies to house data, were $5.74 billion in the third quarter, up 13.3% from the same period a year ago...
Storage [is] growing faster than sales of computer servers -- the other major computer-hardware purchase made by companies -- in each quarter so far. IDC said last week that sales of servers rose 8.1% to $12.5 billion.
Storage growth has been driven by the broad acceptance of data-intensive applications, from digital video and images to vast e-mail repositories. IDC said the capacity of all the storage sold in the quarter was 505 petabytes, 58% higher than the same period a year ago...
And by market share:
1) Hewlett-Packard (NYSE:HPQ): 23.5%
2) International Business Machines (NYSE:IBM): 20.7% - largest growth among top three in sales (19.7% up)
3) EMC Corp. (EMC): 13.7%.
4) Dell (NASDAQ:DELL) (sales up 30.8%)
5) Network Appliance (NASDAQ:NTAP) (sales up 22%)


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Math stops a marriage - level 3
25-03-2015 07:00
Marriage is usually a simple sum of one plus one equalling two, but it wasn't the case for this Indian bride. The wife-to-be dumped her groom on their wedding day after he failed a simple maths test at the altar.
Lovely became suspicious of her potential husband's education after meeting him for the first time in a village in northern Kanpur City. After asking him the sum of 15 and 6, she flatly refused to wed Ram Baran, when he replied with an incorrect answer of 17.
The girl's family claims they had been misled by the potential suitor from the start, but Lovely said she knew something was amiss when she met him.
"They had showed me someone else's photo but another person turned up. The boy neither earns nor could he solve a simple maths question. I've refused to marry him."
The groom's family tried to persuade her to return, but the scorned woman was having none of it. A friend said it would be difficult to get her to change her mind.
"She's good at her studies. She wished to get married to an educated boy."
Local police were called to mediate between the families and both sides returned all the gifts received before the occasion. It seems that picking the perfect partner may be a simple enough equation, after all.
Difficult words: dump (to stop being in a relationship), altar (a religious table used in ceremonies), suspicious (thinking someone is not honest or did something wrong), mislead (to lie to someone), amiss (wrong), persuade (to make somebody think somehing), scorned (angry and hurt), mediate (to help people in an argument), equation (a math problem).
Source: www.ondemandnews.com
How to improve your English with News in Levels:


text: The Holy Mushroom Nov 9, 2008 Jan Irvin is an independent researcher, author and lecturer in archaeoastronomy, astrotheology, ethnopharmacology, shamanism, symbolism, ancient and modern mythology, fertility cults, and ancient and modern religion. He co-authored the book "Astrotheology & Shamanism: Unveiling the Law of Duality in Christianity and Other Religions" with Andrew Rutajit. He also co-produced the DVD "The Pharmacratic Inquisition", also with Andrew Rutajit. He is the curator of the official website for John Marco Allegro, the much criticized Dead Sea Scrolls scholar, and has contributed much to the re-examination of many of Allegro's theories. He contributed research toward the academic article "Wasson and Allegro on the Tree of Knowledge as Amanita", with Michael Hoffman. He brings with him over 15 years of research into the study of ethno-pharmacology and drugs. For the first hour, Jan discusses his book "The Holy Mushroom - Evidence of Mushrooms in Judeo-Christianity", a critical re-evaluation of the schism between John Allegro and Gordon Wasson over the theory on the entheogenic origins of Christianity that is presented in John Allegro's book, "The Sacred Mushroom and the Cross". During hour two, we talk more about the schism between John Allegro and Gordon Wasson and the symbolism behind the concept of Jesus as a mushroom and the fact that some cardinals and bishops to this day are dressed up as mushrooms. We talk about religious art work that contains references to the mushroom, the Mandeans, Lucifer, the Devil, the Jesus Seminar, symbolism in St. Marks Basilica in Venice and much more.Relevant Links theholymushroom.com gnosticmedia.com pharmacratic-inquisition.com John Marco Allegro Dead Sea scrolls Wasson and Allegro on the Tree of Knowledge as Amanita Entheogen Ethnomycology Ethnobotany Andrija Puharich Save the Gnostics The Pharmacratic Inquisition Books or Other Material The Holy Mushroom AstroTheology & ShamanismMore from this Guest Trivium Education The Holy Mushroom The Pharmacratic Inquisition, Astrotheology & ShamanismComments


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Check in from 14h / Check out prior to 10h
Aomori Washington Hotel: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Aomori, Japan.
Aomori Washington Hotel offers 3-star accommodation in Aomori. It also provides meeting rooms, massage services and room service.
Hotel description
There are a range of amenities on offer to guests of the hotel, including internet, parking and a laundry service.
Aomori Washington Hotel provides 248 air conditioned rooms equipped with all the essentials to ensure a comfortable stay. Each one features a flat-screen TV with satellite channels, as well as a private en suite.
Guests of at the hotel are served a satisfying breakfast every day. In the evening, guests can enjoy a drink in the cosy lounge bar.
Aomori Washington Hotel is within a short walk of Aomori Prefecture Tourist Center. It is within a 20-minute stroll of Aomori Station, which allows for convenient access in and around Aomori.
Hotel features
Room Service, Restaurant, Bar / Lounge, Air Conditioned, Refrigerator, Cable / Satellite TV, In Room Movies, Hair Dryer, TV, Shower, En suite, Private Bathroom
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Trademark: 'EDOX'
On 12. 3. 1998 the community trademark application no. 000769265 was filed for EDOX (Word mark) by Electronics for Imaging, Inc. before the OAMI.The goods and services in respect of which registration of the trademark was sought are in class 9. The current status of the trademark is registration expired.
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March 7, 2012 - Contractors
ITD Users
- Contractors will now additionally be allowed to be in a) zero service groups, b) multiple service groups. Previously, contractors were required to be in one (and only one) service group.
- Contractor information will continue to be sent to EmpCenter for 90 days after termination, in case amendments are needed. Previously, contractor information was only sent for 30 days.


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The Photography Show, a destination for all photographers
Looks like "Hear no evil, See no evil, Speak no evil" to me.
I wonder what they are singing?
Three stars on the horizon ?
As beautiful as can be!
Three stars on the horizon ?
As beautiful as can be!
"we're not singing 'til we've been fed!"
Wonderful grouping and cracking title, Julia.
Wonderful grouping and cracking title, Julia.
The title is spot on I like the way you left out the "H", good shots need a good title this has both good work
It looks like you made them sing for their supper, superbly captured
Great title. Well deserved marks and awards. Could grace any book.
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