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PASADENA, Calif. -- A bad season of college football for Southern California -- and in Southern California -- came mercifully to an end with USC's 28-14 win over UCLA on Saturday night at the Rose Bowl. It was a clutch win in a meaningless moment.
Unless your name is Allen Bradford, and it's probably not, Saturday was all about one thing for USC: avoiding disaster.
The night began that way, and it ended with the Trojans keeping the floodwaters at bay. They held back a storm of negativity that could have swamped the program heading into a crucial offseason. It was the worst season for USC in a decade, but it could have been worse.
Nobody even made much pretense that this was anything other than disaster control. That and -- of course -- one more slap at the Trojans' archrival, stuck in a miserable funk.
To lose Saturday would have turned uncertainty into a murky mess, maybe set back the rebuilding process for years. To lose to a mediocre Notre Dame team and a bad UCLA team ... hard to fathom, isn't it, USC fans?
"This would have been awful to lose to our two rivals in back-to-back weeks. It would have been a long offseason," USC athletic director Pat Haden said. "Listen, we lost five games, we're not happy about that, but it's a great way to end the season."
The Trojans (8-5, 5-4) were good enough to go to a bowl game -- a minor one in some hard-to-reach spot -- but that's kind of not what it's about at USC. The goal is to hold steady through the painful years and set up a platform for launch time, say around fall of 2012 or maybe a little sooner.
Even the guys on the way out the door saw Saturday as more about the future than the present and certainly not the past. It became painfully evident the past few weeks that things aren't the same around Heritage Hall and haven't been for a while.
"It's going to change. Things are going to turn around over here, and I'm glad to be a part of this foundation," senior fullback Stanley Havili said.
There will be more to build on if a couple of draft-eligible underclassmen, offensive tackle Tyron Smith and defensive tackle Jurrell Casey, return. Casey said he'll meet with the coaches next week before making up his mind, but he sounded excited about the team's potential. Then again, it's kind of easy to get excited about a bunch of money, too. If you're hoping Casey returns, note the "we" below:
"This is going to set us up for next year, build the fire and get everybody to play harder than ever," Casey said. "We'll just keep on going and, hopefully, next year we have a better record."
USC coach Lane Kiffin showed his soft side Saturday, featuring Bradford, the fifth-year senior who had waited behind an ever-changing line of starting tailbacks. Bradford ran explosively, scoring two touchdowns, including a 73-yard dash and a 47-yard screen pass that he took and streaked down the sideline with. Bradford had 267 total yards, 220 of them rushing on 28 carries.
The Trojans' defense, a liability most of the year, showed signs of eclipsing the offense in the final weeks. UCLA, far from a machine, broke down and sputtered under an aggressive USC pass rush. Richard Brehaut was sacked twice by Armond Armstead and hounded all night.
But the offense, other than Bradford, was anemic, hardly offering a glimpse of high-flying endeavors to come. Quarterback Matt Barkley, playing with a high ankle sprain, threw two interceptions and completed just 15 of his 26 passes. USC searched all year for the complete game but rarely found it. That's something to wonder about.
"We've been showing signs of greatness here or there, the offense at the beginning, the defense at the end," Casey said. "As soon as we get them all together, it's going to be a great year."
Of course, if they don't look forward to 2011, what are they going to look forward to, the appeal process? That sounds like about as much fun as a visit to the county auditor.
But it would be a mistake to say that this team quit. It could have checked out after a second straight last-second loss at Stanford in early October. At that point, with a 4-2 record, what was there to play for? Not the Rose Bowl, of course. Saturday night's appearance there was the only one USC would get to make. Then again, it wasn't going to be invited to San Diego, San Antonio or El Paso, either, thanks to the NCAA's bowl ban.
USC showed surprising resolve when it didn't really have to. The Trojans played their best game against Cal the next week, had a third-quarter lead against Oregon and then swept the Arizona schools.
USC was turning back into USC, it seemed.
Only it wasn't. Things fell apart where they often do for this team, Corvallis, Ore., a friendly little college town to most, a carnivorous plant to the Trojans. The loss to Notre Dame at home was even more difficult to swallow, especially for receiver Ronald Johnson, who was left speechless by his late drop of what would have been the go-ahead touchdown.
It generally felt like a joyless season -- in part because of the sanctions, in part because Kiffin seemed perpetually miserable (and that was after the wins). There also weren't a lot of good outcomes on the table. An 8-5 USC team is a miserable USC team, but, of course, not quite as miserable as a 7-6 USC team.
If the juniors stick around, USC will have 16 offensive and defensive starters coming back next season. They'll have a year of experience with the coaching staff. School officials are cautiously optimistic that they can get some of the sanctions cut in half at a January appeals hearing. In other words, 2011 has hope, the most fragile commodity of all around this team.
Mark Saxon covers USC football for ESPNLosAngeles.com. Follow him on Twitter. Follow him on Twitter.


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Halloween (National Geographic Readers)
From visiting the pumpkin patch, to bobbing for apples, to picking out a favorite costume, Halloween is a magical time for young children. The fun and festivities are captured in this book, with full-color illustrations and simple easy-to-grasp text. In the spirit of this beloved holiday, this level one reader is sure to captivate and fascinate children.
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Hardcover, 32 pages
Published July 10th 2012 by National Geographic Children's Books
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Dec 16, 2016 Earl rated it liked it
Simple guide with enough text and pictures for super young readers about Halloween.
Sep 21, 2012 Jaime rated it really liked it
My daughter Ella liked it & I though it was educational and great for pre-school age! She loves books on my nook!
Dec 02, 2012 Tiffany rated it really liked it
Shelves: theme-books, informative-books-for-kids, science
This book is awesome, with real life pictures. This is an awesome book to pull-out during the season; it's great for crafting ideas.
Apr 12, 2013 Hannah Sheffield rated it it was amazing
Shelves: children-s-book, children, fall, halloween, nonfiction
This book has a lot of great information in it. It also has bright pictures and catchy rhymes. The last page even has a little activity.
Jan 20, 2013 Mrs. Ruigrok rated it it was amazing
Shelves: halloween
I love the photographs and the information in the National Geographic books. They catch the eye of my students who are quick to pick these books for information.
Jul 31, 2012 Karen Arendt rated it really liked it
Shelves: independent-reader, nonfiction, holiday
Excellent photographs will appeal to children. Much of the information is known to most children who celebrate Halloween. A few interesting facts include. Excellent layout.
Oct 23, 2012 Brandi Streeval rated it it was amazing
bought my daughter this from scholastic school book form very neat and cute book
Oct 31, 2012 Yekaterina rated it it was amazing · review of another edition
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Great overview of Halloween.
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ETH Academy on Sustainability and Technology 2016
Main content
Innovation for Sustainability: The Role of Technologies, Organizations, and Institutions
June 17-22, 2016, ETH Zurich
The many sustainability challenges facing society in the 21st century, such as climate change, resource scarcity, and the transformation of the energy system, require new technologies and new approaches to be developed and diffused. Organizations and institutions, such as public policy, influence and in turn are influenced by these innovation processes. These actors are, as a result, central to global efforts to effectively respond to sustainability challenges.
While the previous 8 successful ETH Academies on Sustainability and Technology were aimed at PhD students, this year we would like to invite not only PhD students but also postdoctoral researchers and junior faculty. This year's academy is concerned with technological, organizational and institutional change in the context of sustainability (e.g. energy, climate, water). It provides a unique platform for junior researchers with a background in innovation studies, management, economics or political sciences to present their work to an audience of like-minded scholars and four international faculty with a track record in research on innovation and sustainability. Participants will obtain detailed feedback on their research design, theoretical approaches and methodology. In addition, there will be plenty of room for informal discussions and networking with other junior scholars and professors. Students in previous years have come from, amongst others, the Massachusetts Institute of Technology, Stanford University, the University of Michigan, the University of Cambridge, and Oxford University.
Research of the participants should focus on – but is not limited to – the following topics:
- Technology and innovation strategies of organizations in the context of sustainability
- Technology and innovation policy for energy, climate or water
- Role of institutions for technological and organizational change in the context of sustainability
- Innovation systems and technological change in the context of sustainability
- Socio-technical or techno-economic assessment of technologies related to sustainability
The ETH Academy on Sustainability and Technology will take place in a hotel in the midst of the Swiss Alps. To guarantee an intensive learning process, attendance is limited to 15 participants. Third-party funding allows us to offer a participation fee of only CHF 400 (ca. 460 USD) which covers accommodation, meals and excursions.
Applications should be sent to Aoife Brophy Haney () and include (i) a cover letter explaining your motivation, (ii) a proposal abstract of max. 2 pages, and (iii) a CV. The deadline for application is March 13, 2016. Notification of acceptance will be given by April 1, 2016. Deadline for full paper submission (10-15 pages) is May 1, 2016. For additional information, please see the previous academies' programs on our website (http://www.sustec.ethz.ch/education/PhD_Academy/) or contact Aoife Brophy Haney. We look forward to receiving your application!
Jessika Trancik is the Atlantic Richfield Career Development Assistant Professor of Energy Studies at the Institute for Data, Systems and Society (IDSS) at the Massachusetts Institute of Technology. She is also an external professor at the Santa Fe Institute. She received her B.S. in materials science and engineering from Cornell University and her Ph.D. in materials science from the University of Oxford as a Rhodes Scholar. Before MIT, she spent several years at the Santa Fe Institute as an Omidyar Fellow, and at Columbia University as an Earth Institute Fellow, where her research focused on energy systems modeling. Her research group studies the dynamic costs and environmental impacts of energy technologies to inform technology design and policy.
Dr. Trancik's work has been published in journals including Nature Climate Change, Environmental Science and Technology and the Proceedings of the National Academy of Sciences. Her work also features regularly in the press including outlets such as NPR and Grist.
Andrew H. Van de Ven is Vernon H. Heath Professor of Organizational Innovation and Change in the Carlson School of the University of Minnesota and founding editor of Academy of Management Discoveries. He received his Ph.D. from the University of Wisconsin at Madison in 1972, and taught at the Wharton School of the University of Pennsylvania before his present appointment. He teaches courses on the management of innovation and change, organizational behavior, and research methods.
Van de Ven has been studying changes unfolding in health care organizations and industry. During the 1980s he directed the Minnesota Innovation Research Program in which 30 faculty and doctoral students tracked fourteen different kinds of innovations from concept to implementation.
In addition to organizational innovation and change, Van de Ven's books and journal articles over the years have dealt with the Nominal Group Technique, organization assessment, inter-organizational relationships, and research methods. He is co-author of 12 books, including: The Innovation Journey (1999, 2008), Organization Change and Innovation Processes (2000), Handbook of Organizational Change and Innovation (2004), and Engaged Scholarship (2007), which won the 2008 Terry best book award from the Academy of Management. During 2000-2001 Van de Ven was President of the Academy of Management.
Desirée Pacheco holds a Ph.D. in Management and Entrepreneurship and an M.S. in Environmental Studies from the University of Colorado at Boulder, and a B.S. in Industrial Engineering from the University of Puerto Rico. Prior to her doctoral studies, Professor Pacheco worked as a management and technology consultant with Accenture. During this experience she worked with established and start-up companies in defining their strategic direction and implementing new processes and systems. In addition, Professor Pacheco has experience teaching courses in the areas of strategic management, entrepreneurship, and environmental studies.
Professor Pacheco was recently granted the 2015 Emerging Scholar Award by the Organizations and the Natural Environment (ONE) division of the Academy of Management. This award is granted to early career academics who have already made outstanding research contributions in the area of organizations and the natural environment, and who appear to have a strong potential to continue making such contributions in the near future.
Dr. Pacheco's research interests relate to the interface between institutions, entrepreneurship, and firm strategy. She often applies these areas of research to the study of sustainable business. Her research has been published in the Journal of Business Venturing, Journal of Management, Organization Science, Strategic Management Journal, and The Academy of Management Journal; amongst other publications. Professor Pacheco is an editorial board member of the Journal of Management and the Journal of Business Venturing.
Volker Hoffmann is full professor for sustainability and technology at the Department of Management, Technology, and Economics of ETH Zurich.
He received a diploma in chemical engineering from ETH Zurich in 1997 and a diploma in business administration from the University of Hagen, Germany, in 1999. In 1996/97 and 1999/2000 he worked as a visiting scholar and scientist at MIT where he investigated uncertainty propagation in large scale process models for the chemical industry (group of Gregory J. McRae). In 2001, he obtained his Ph.D. from ETH Zurich with a thesis on multi-objective decision making under uncertainty in chemical process design (group of Konrad Hungerbühler). Before joining the faculty of ETH Zurich in 2004, he was a project manager at McKinsey & Company where he worked in the chemical and electricity industry. He focused on strategy development for European utility companies, especially in the light of upcoming greenhouse gas regulations. During his career, Volker Hoffmann received several scholarships and awards including a German National Academic Foundation Scholarship (1994-97), an Ernest-Solvay-Scholarship (1996/97), and an Exchange Fellow Scholarship of the Alliance for Global Sustainability (1999/2000).
Volker Hoffmann's research at ETH Zurich centers on corporate strategies with respect to climate change, with a focus on climate policy, energy policy, and innovation. Recent research results are being published in journals such as the Journal of Management Studies, Long Range Planning, the California Management Review, Research Policy, Climate Policy, Energy Policy, Global Environmental Change, the Journal of Industrial Ecology, Policy Sciences, Environmental Science & Policy, Energy Economics, the European Management Journal, Business Strategy & the Environment, Environmental Science & Policy and Ecological Economics.


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Campanile Poitiers - Site du Futuroscope, Chasseneuil-du-Poitou
- Free WiFi and free parking
Main amenities
- 193 smoke-free guestrooms
- Restaurant and bar/lounge
- Breakfast available
- 3 meeting rooms
- Terrace
- 24-hour front desk
- Air conditioning
- Daily housekeeping
- Garden
- Meeting rooms
- Multilingual staff
- Free newspapers in the lobby
For families
- Free cribs/infant beds
- Rollaway/extra beds (free)
- Connecting/adjoining rooms available
- Private bathroom
- Separate bedroom
- Free toiletries
What's around
- Futuroscope (0.7 mi / 1.1 km)
- Musée Chez Manuel (2.8 mi / 4.5 km)
- Notre Dame La Grande (6.8 mi / 11 km)
- Place du Marechal Leclerc (7.7 mi / 12.5 km)
Campanile Poitiers - Site du Futuroscope, Chasseneuil-du-Poitoufrom $43
- Next Generation, Family Double Room, 1 Double Bed, Non Smoking
- Triple Room with double bed & extra bed
- Twin Room
- Double Room
- Next Generation, Quadruple Room
- TripleRoom wth 2 singles & 1 extra bed
- Next Generation, Twin Room
- Quadruple Room
- Next Generation, Family Twin Room
- Next Generation, Double Room
- Standard room with two single beds
- Double Room
- Twin Room
- Double Room Next Generation And One Extra Bed
- Double Room
More great choices
At a glance
Key facts
Hotel size
- This hotel has 193 rooms
- This hotel is arranged over 3 floors
- 24-hour check-in
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (10 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets allowed *
- Up to 10 kg
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Other information
- Smoke-free property
Nearby Three Star Chasseneuil-du-Poitou hotels
In the hotel
- Buffet breakfast daily (surcharge)
- Restaurant
- Bar/lounge
- Golfing nearby
- Number of meeting rooms - 3
- Meeting rooms 3
- 24-hour front desk
- Tours/ticket assistance
- Free newspapers in lobby
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 3
- Elevator/lift
- Garden
- Terrace
- Accessible bathroom
- In-room accessibility
In the room
- Air conditioning
- Coffee/tea maker
- Iron/ironing board (on request)
- Premium bedding
- Private bathroom
- Bathtub or shower
- Free toiletries
- Hair dryer (on request)
- Digital TV channels
- Desk
- Free newspaper
- Free WiFi
- Phone
- Daily housekeeping
- Connecting/adjoining rooms available
Top Chasseneuil-du-Poitou hotels
Recently reviewed hotels in Chasseneuil-du-Poitou
- Garrigae Manoir de BeauvoirFrom
"We were just staying one night for go further."Nov 3, 2016
- Les Loges du Parc & SpaFrom
"this hotel has unique personality including good service, quality breakfast. The swimming pool with the thermal water is absoluteley gorgeous. We loved this place!!!"Jul 11, 2016
- Domaine du NormandouxFrom
"a relaxing retreat for a family or couples; wonderful dinner and breakfast; the room also had a well furnished kitchenette; only drew back was unreliable Internet"Jul 5, 2016
- Best Western Le Bois De La MarcheFrom
"Short night after wedding event"Oct 6, 2015
Nearby hotels
Also popular with travelers from the USA
Campanile Poitiers - Site du Futuroscope, Chasseneuil-du-Poitou's small print
Also known as
- Campanile Poitiers Site Futuroscope Chasseneuil-du-Poitou
- Campanile Poitiers Site Futuroscope Hotel Chasseneuil-du-Poitou
- Campanile Poitiers Site Futuroscope Hotel
- Campanile Poitiers Site Futuroscope
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 0.90 per person, per night
- Christmas Eve (24 December) Gala Dinner per adult: EUR 26
- New Year's Eve (31 December) Gala Dinner per adult: EUR 110
- Shuttle transfer per adult: EUR 6 (one way)
Optional extras
Buffet breakfast is offered for an extra charge of EUR 9.90 for adults and EUR 4.75 for children (approximately)
Pets are allowed for an extra charge of EUR 5 per accommodation, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Good 3.6 /5 from 159 reviews
overnight stay. Bit like a travellodge. Just off main road.Not much around.Small modern rooms but clean and ok to just sleep in.Shower good.
Well used,maybe time for a re furb, otherwise good for overnight stop
Family visit to Futurescope and this provided an xcellent base for visiting the park and all the amenities
Very disappointed with our room. There was no blind at window only a net. Felt uncomfortable with people walking by. As we laid in bed. The hotel was very difficult to find. Not sign posted .
We have stayed at this brand hotel previously and although not as modern as other hotels was perfect for a budget hotel for 1 night. We were in a disabled apartment so larger than normal. We went for dinner very late and restaurant was extremely busy but we were prepared to wait as the food lived up to expectations from other hotels we stayed at.
Is the description of this hotel not correct? Tell us


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July 4, 2013 I analyzed the Seguin (and company) for Ericsson (and company) trade, and said to ask in five years to see who won. Given the number of young players in the deal (Seguin, Morrow, Fraser, Smith) it is
The Bruins off ice leadership is pretty consistent. They do the same things over and over, and for their part the Bruins fans just take it with little complaint. Chiarelli and Neely dangle a new, young, talented player in front of the fans, then punting that player or players away just as soon as enough tickets are sold or they fail to play like a fifth year veteran by the end of their sixth shift.
Its never a good thing when a team and player can't manage to combine for the common good. Sometimes the player is a misfit, other times the teams flat fail to appreciate the talent of a player and put him
Have you ever seen a magic show? David Blaine, Siegfried and Roy, or one of the others? A lot of how they do what they do is through distraction, misdirection, and convincing you what you are seeing is what they
In life, in business, in relationships and in the NHL, neither success nor failure are instant. On occasion it appears that a team or business has succeeded or failed in the blink of an eye, what you are seeing is
The western conference will kick off the playoffs with the Anahiem Ducks and Dallas Stars facing off in 1st versus wild card matchup. The Jamie Benn led Stars crossover from the Central Division to face Corey Perry and his west
The Western Conference has run over the east so far this year. The odd thing is how concentrated the losses are, so many of the east's teams are in complete disarray while most of the weakest of the western teams
This feature will run approximately every two weeks each season comparing a well known player to leagues newest crop of rising stars. NHL rookies are making the biggest adjustment to their play, and their awareness of the game since they
This is a feature that will run about every two weeks with improbable stats and situations in the National Hockey League. Teams: The Philadelphia Flyers would be the first team to fire their head coach promoting Peter Laviolette to


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Add new comment
I agree. Although I never
Permalink Submitted by Judith K on Sun, 2014-06-08 09:57
I agree. Although I never felt like turning the show off, her arrogance and narcissistic nature pervaded throughout the interview, and had I been Krista, I would have had a hard time being polite with her, since she was so blatantly egotistical and yes, even rude. [As someone mentioned earlier, the chiding of Krista for her "slightly original" remark was totally annoying, not to mention inappropriate]. However, the woman did have a lot to say of merit. I guess sometimes we don't have to like the messenger, we just have to hear the message.


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ARLINGTON, Texas -- Alberto Gonzalez will play shortstop in the series finale tonight with the Seattle Mariners as Elvis Andrus gets a day off.
"I'm feeling good," Andrus said. "It's more a mental day off. One day is great. Two is like a vacation. I'm going to enjoy it, but I'll be ready of they need me."
Andrus has had a few defensive slip-ups and admits that maybe being mentally fatigued contributed.
"You can be 100 percent physically, but if you're not mentally, that can get to you," Andrus said.
The lineup:
2B Ian Kinsler
LF David Murphy
RF Nelson Cruz
SS Alberto Gonzalez


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Mt. Diablo State Park. I love the vistas on a clear day, and our grandchildren love to go play at Rock City where the Miwok Indians used to grind their acorns. It's also nice and close. My husband rides his bike up there all the time.
Marilee Tinker
retired Baldwin Elementary School teacher
We go to Mount Shasta every summer and enjoy the lake and go boating. We hang out with family, and we have all hiked into the Lake Shasta caverns. It's gorgeous up there!
Kristen Barker
Alamo Realtor
Point Bonita in Marin County, out past the Golden Gate Bridge. It's the best views of the ocean and the city at the same time. Along the way, it's one of the nicest drives anywhere. I like exploring the abandoned military encampments along the cliffs. I just go for the day, but it would be nice to camp out there sometime.
Mike Sallstrom
UC Santa Barbara freshman
My favorite is Yosemite. I like to visit there every season and have probably gone there at least once a year since I can remember. In the summer we like to go rafting from Curry Village. My brother and I climbed Half Dome from the backside up the cable when I was 13. I like the beauty and the quiet there.
Kathy Karp
Sycamore Valley Elementary School resource para-educator
I like Mono Lake State Park. Driving down the backside of the Sierra is an awe inspiring and breathtaking experience, especially when going over Tioga Pass. The sheer number of different types of birds that migrate through there is mind boggling, and the tufas are a strange phenomenon and quite a sight. The visitor's center is one of the best I've seen.
Kevin DeLano
UC Davis sophomore
This story contains 306 words.
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- 07-28-2014, 09:37 AM Thread Author #1Junior Member
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[FREE GAME] Sand Fisher
Use your sharp eye, reflexes and tactics to catch them all! Create the sand barriers by swiping your finger over the water, but watch out! If you hit the fish you will lose life! Convert at least 80% of water to sand and you will win. Piece of cake with two fish, but pretty hard with ten.
Sand Fisher is simple casual game perfect for killing some spare time. Enjoy colourful fishes, action and a bit of brain teasing. You have to be fast, you have to be precise and you have to think before you will place a sand barrier. More fish means more points. Lost life will seriously hurt your score so be careful!
Google Play ▷ https://play.google.com/store/apps/d...ign.sandfisher
Developers: AURADESIGNCZ
Size: 20M
Requires Android: 2.3 and up
Content Rating: Everyone
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Re: [FREE GAME] Sand Fisher
Welcome to Android Central, and good luck with the game!
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
I have a 12yr. old son with autism. His dad put the both of them on county aid. As a result from that, I am now ordered to pay child support. If I can get my boy on SSI disability for children, would I still be required to pay child support? Am I also going to have to pay back his SSI? I only work about 12 hrs. a week. the rest of the time I am with him
If the disability payments are being received from the Federal Government (social security disability, VA benefits, etc.) because of the non-custodial parent's disability, they are deducted from the non-custodial parent's support obligation. However, it appears that your child and his father are receiving support from the State. In that case, the State requires you to pay support in order to reimburse the State for the benefits.
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Huge Opportunities Are Now Possible Due to Market Inefficiencies in Valuing Antibiotic Companies such as Cubist, Durata, and Cellceutix
Antibiotics became cheap generics and Pharmas abandoned the antibiotic market in droves. But times are changing.
Globally, pharmaceutical companies were once prolific antibiotic makers. In the 22 years to 1962, 20 new classes of antibiotics were discovered, but only two in the last 52 years. Just a few years ago, big pharmaceutical companies were jumping out of the antibiotic drug discovery and development business. The reason was pretty simple, as the Food and Drug Administration's regulatory pathway was long, expensive and difficult to maneuver to bring a new antibiotic to market. Most of the select drugs that have made it through the FDA approval process were simply iterations of existing drugs. The cheap generic drugs were effective, leaving little incentive for creating new drugs which can generate significant sales. However, changes are happening due to the dire need for new antibiotics.
How Bad is the Need for New Antibiotics?
The British Pharmacological Society suggests that another 20 classes and subsequent analogues, with an emphasis on Gram-negative therapies, could last us another six decades, but it will take a unified effort of researchers and government support to make that happen. On that point, the Infectious Diseases Society of America says that at least 10 new drugs that can treat superbugs are necessary by 2020.
The dearth of antibiotic discovery complex has given bacterium decades to mutate and grow resistant to available drugs, rendering many of them relatively - or completely - ineffective.
"The truth is, we have been abusing [antibiotics] as patients, as doctors, as travelers, and in our food," said Professor Dame Sally Davies, Chief Medical Officer for England, in her book "The Drugs Don't Work - A Global Threat". "We are staring at a future in which antibiotics don't work, and many of us or our children will not be saved from TB, cholera, deadly forms of dysentery, and germs contracted during surgery," Davies told attendees at a UK-based Chatham House meeting in March. She believes that people may start dying from common operations and conditions that can be treated today as bacteria continue to outsmart today's drugs.
Some may call it fear mongering, but the multi-drug antibiotic resistance threat is very real and at a global scale. It's slated to be a topic at the World Health Organization (WHO) at its annual assembly of health ministers next month. The Centers for Disease Control and Prevention issued "Antibiotic Resistance Threats in the United States, 2013" to heighten awareness about the seriousness of problem. Precious Matsoso, Director General of Health of South Africa, recently called a meeting to express her concern over superbugs and to discuss a strategy to deal with the situation, including antibiotic resistance related to malaria and a case of Klebsiella pneumoniae last year in South Africa that was resistant to every known antibiotic.
Millions of people become sick from bacterial infections each year with about 50,000 people in the U.S. and Europe dying from them, according to the WHO. The CDC estimates that the 2+ million people that are infected with drug-resistant bacteria annually resulting in direct costs of up to $20 billion.
Big Pharma Slowly Getting Back In The Game Because There's Big Money To Be Made
Some experts contest that a new antibiotic will not reach blockbuster status. Based upon published research on antibiotic resistance and commentary from leading pundits globally, there is certainly an argument to be made against that case. Lending credence to the value of new antibiotics, several companies are once again opening their R&D doors and wallets. The realizations have set in that life saving drugs can be sold for as much as $1,000 a pill or dose, as shown recently by Gilead with its Hepatitis C treatment drug Sovaldi. Sovaldi will cost $1,000 per pill. A typical course of treatment will last 12 weeks and run $84,000, plus the cost of necessary companion drugs. Some patients may need treatment for twice as long.
After more than a decade on the sidelines, Roche (OTCQX:RHHBY) stepped back in the game in December, spending $40 million upfront and earmarking another $520 million for milestone payments and double-digit royalties in a deal with Switzerland-based Polyphor, mainly to advance POL7080 for hospital-acquired Pseudomonas aeruginosa. Part of a new class of drugs called macrocycles, POL7080 is a synthetically engineering drug that is slightly bigger than a small molecule, but packs the potency of a large molecule.
Genentech, a biotech that Roche spent $46.8 billion in 2009 to buy the 44 percent that it didn't already own, made an undisclosed upfront payment and agreed to shell-out $111 million more in milestone awards - as well as royalties - under a drug discovery deal with two-year old RQx Pharmaceuticals to research new antibiotics. RQx is focused on modifying arylomycin compounds, naturally produced narrow-spectrum antibiotics that most bacteria are resistant to, but altering their structure could lead to a new class of broad-spectrum drugs.
Cubist Pharmaceuticals, Durata Therapeutics, and Cellceutix Corporation
Cubist Pharmaceuticals (CBST) is an excellent case about the value of new antibiotics. Cubist's Cubicin, an injectable version of the antibiotic daptomycin, topped $1 billion in sales in 2013 even though it competes against a generic antibiotic, vancomycin. As resistance grows among the population to vancomycin, Cubist' sales keep growing. Cubist is aiming to become a global leader in antibiotics, saying it plans to spend roughly $400 million in 2014 to develop its antibiotic portfolio for infections that the CDC has deemed as serious threats, including Pseudomonas aeruginosa, as well as extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli), Klebsiella pneumoniae, and other Enterobacteriaceae bacteria.
Late in March, Cubist won unanimous approval of an FDA advisory panel for tedizolid phosphate, a drug it wants to market under the brand name Sivextro for Gram-positive Acute Bacterial Skin and Skin Structure Infections (ABSSSI), including those caused by methicillin-resistant Staphylococcus aureus (MRSA). The FDA doesn't have to follow the recommendation of the advisory panel (although it often does) and a final decision is expected by June 20. Cubist spent $707 million in cash and committed to another $111 million in milestone payments to get the drug by acquiring Trius Therapeutics last July. The CDC estimates that there are more than 80,000 MRSA infections in the U.S. every year, resulting in in excess of 11,000 deaths.
Cubist has also recently hit its primary endpoints in a phase 3 trial of ceftolozane/tazobactam for treatment of urinary tract infections and intra-abdominal infections and plans to submit applications for FDA approval by the end of June. Further, the company is marketing Dificid for the treatment of C. difficile infections. Dificid was the lead drug of Optimer Pharmaceuticals, a company Cubist spent $535 million in cash and committed another $266 million in milestone payments to acquire at the same time it bought Trius.
If Sivextro garners FDA approval it will go head-to-head with Pfizer's (NYSE:PFE) Zyvox (linezolid), the current market share leader with $1.4 billion in sales in 2013. Zyvox is losing patent protection next year, which will mean a run of generics hitting the market, but they likely will meet the same fate as Zyvox likely would anyway: some limited acceptance due to being a longer-course therapy than Sivextro. A six-day dosing regimen for Sivextro is expected to be given in IV form at a hospital and then the patient will take it in pill form from home. This compares to Zyvox's dosing scheme of twice daily for at least ten days. For comparably priced antibiotics to treat MRSA and severe skin structure infections, about 66% of pharmacy directors support keeping formularies stocked with shorter-course therapies because it promotes earlier patient discharge.
From payers to patients, everyone knows how fast hospital bills add up. Even if the absolute price of Sivextro appears to be more, the savings from patients leaving the hospital sooner will counterbalance to price tag. Further, Sivextro is believed to have a better safety profile and at least equal efficacy to Zyvox, likely leaving Pfizer's drug as the odd man out.
Durata Therapeutics (NASDAQ:DRTX) MRSA/ABSSSI drug dalbavancin, which is planned to be marketed under the brand name Dalvance if approved, is also on the FDA's decision itinerary, following an FDA advisory board also giving the drug candidate their blessing. Durata's late-stage, three-arm trial of dalbavacin showed that the drug was not inferior to the commonly used IV antibiotic vancomycin or vancomycin followed by Zyvox. From purely a number of doses standpoint, Dalvance takes the prize compared to current drugs, with one infused dose given on the first day and then a second infused dose coming on day eight. A concern I have is the choice of vancomycin as the comparator drug for showing non-inferiority. As resistance to vancomycin is growing the market is moving towards the less resistant drugs such as Cubicin/daptomycin.
In a Reuters' article on March 31, 2014, the day the FDA advisory board voted in favor of recommending the FDA approve Dalvance, the article states "one analyst polled by Thomson Reuters sees delbavancin sales reaching $449 million by 2019". The article acknowledges that this is on the high side as the article also states, "If approved, the drug is expected to generate annual sales of $219 million by 2019, according to the average estimate of six analysts polled by Thomson Reuters". The article continues that the drug already has some pressures looming over it. For starters, the FDA advisory panel had some concerns about potential side effects of dalbavancin on the liver, especially in patients with liver disease.
The second question regarding the dosing regimen could be even more problematic. It's been long-argued that one of the major problems with the emergence of antibiotic drug resistance has been patient compliance. Simply, people take an antibiotic until they feel better and then don't complete the program, allowing the bugs to weaken, but not die and then grow stronger with a resistance to the treatment. On that point, it is not difficult to surmise that plenty of people may get a Dalvance infusion at the hospital and then never return on the eighth day to complete the protocol. Think about it. If someone feels fine, do you think they will take the time to head back to the hospital? By not doing so, the cycle of antibiotic resistance is actually being exacerbated, not stifled, and that could be to the long-term peril of Dalvance. Durata realizing this potential limitation to market acceptance announced today that they are initiating a phase 3b study of Delvance as a 1500mg. single dose. This higher single dosing still does not remove the issues of toxicity and resistance issues related to its comparator vancomycin.
The key takeaways here is that pharma is back on the path to develop new antibiotics and spending money to partner, even if drug candidates are still in the early stages. Analysts are pegging annual sales in the hundreds of millions for Sivextro and Dalvance, primarily because they are shorter-course therapies than available drugs today.
The Dark Horse May Be the Best Horse
With the spotlight on these two drugs, the dark horse in the race is Cellceutix Corp. (OTCQB:CTIX) with Brilacidin, a novel antibiotic licensed from the University of Pennsylvania. Brilacidin represents a new class of drugs called defensin-mimetics and is in a phase 2b clinical trial for ABSSSI. Defensin-mimetics are modeled after host defense proteins, the first-line of defense in the immune system. They destroy bacteria the same way that the body does naturally, decreasing the risk of antibiotic resistance developing.
A previous 215-patient phase 2a clinical trial hit its primary endpoints while comparable in efficacy to daptomycin.
Cellceutix snagged Brilacidin, in its acquisition of the assets of PolyMedix following the embattled biotech filing for bankruptcy protection last year. With a price tag of only $2.1 million in cash and 1.4 million shares of CTIX stock, taking ownership of much of the corporate assets of PolyMedix is looking more like a heist than an acquisition at this point. The reason is pretty simple as it parallels the logic behind the valuations of Sivextro and Dalvance.
$449 million. That's the aforementioned figure that a Reuters' story mentions an unnamed analysts put on annual sales of Durata's Dalvance and the therapy requires a return visit to the hospital for a second infusion 8 days after the first. In Cellceutix's 200-patient trial, patients are being treated with Brilacidin in three different dosing regimens, including two single-dose regimens, and compared to patients being treated with Cubist's Cubicin. The longest dosing regimen for Brilacidin in the trial is three days, meaning that Brilacidin has the most favorable dosing schedule compared to Sivextro and Dalvance, or anything currently on the market for that matter.
Enrollment in the Brilacidin trial is on schedule at 40 patients per month and no drug-related serious adverse events have been reported to date, according to Cellceutix. At the current pace, enrollment should be completed sometime in August with the data unblinded likely in September. Cellceutix says that it intends to use the data to conduct a phase 3 pivotal trial of Brilacidin for ABSSSI. If the data shows that Brilacidin could indeed be a single-dose antibiotic, it would seem highly probable that big pharma will come calling to partner for a phase 3 trial. Simply, a "one-shot/one-kill" antibiotic would control the market, and that's too compelling of a proposition for majors to pass-up.
Cellceutix is also building upon previous Brilacidin research that shows the novel drug could work on a host of other indications, including Gram-positive and Gram-negative bacterial infections. The company says it is finalizing research necessary to start clinical trials of Brilacidin-OM for oral mucositis, an often-debilitating side effect of cancer therapy. Research funded by government grants is being conducted at an undisclosed major university in Texas, which recently showed the drug to be active in mouse models against Klebsiella pneumoniae. Additional studies at the university lab are slated to evaluate Brilacidin versus multi-drug resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Candida, keratitis, conjunctivitis, otitis and other infectious conditions and diseases have all been listed as targets for research by Cellceutix.
Outside its antibiotic pipeline, Cellceutix is in the late stages of a phase 1 clinical trial of its novel cancer drug, Kevetrin, for solid tumors being conducted at Harvard's Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center. Screening for a brief phase 1 crossover study of anti-psoriasis drug Prurisol is ongoing, an 8-week trial that is required to allow the company to take the drug into a phase 2/3 trial under a 505(b)(2) designation by the FDA.
From an investment perspective, Durata's market capitalization rose from about $175 million to $360 million since July because of its advancement of dalbavancin for ABSSSI, the only drug they have in their pipeline. With Durata's newly announced phase 3b clinical trial, Cellceutix's Brilacidin may trail Durata by only about 8 months in the clinical trial timeframe, but Brilacidin could hands-down be the better antibiotic because of the fact that it is a (much-needed) new class of drug and as such would have no bacteria already resistant to it, as well as having none of the toxicity and resistance issues associated with vancomycin class drugs. With Cellceutix's valuation of $168 million, the markets have failed to give any consideration to Brilacidin, as the market cap has essentially been flat ever since the acquisition last September. This should really be viewed as an anomaly that will be corrected as Cellceutix arguably has one of the most robust antibiotic pipelines of any biotechnology firm, large or small. With regulatory agencies implementing policy changes to make the pathway to commercialization of new antibiotics less onerous, Cellceutix certainly seems to have aligned itself in an enviable position.
Closing stock prices and market caps as of April 24, 2014:
Cubist Pharmaceuticals CBST $66.51/share and $4.97 Billion
Durata Therapeutics DRTX $13.48/share and $359.11 Million
Cellceutix Corporation CTIX $1.59/share and $168.34 Million
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article.
Editor's Note: This article discusses one or more securities that do not trade on a major U.S. exchange. Please be aware of the risks associated with these stocks.


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Taylor Swift NOW will launch later this year.
The series, which launched Thursday, is part of AT&T and Fullscreen's Hello Lab program.
AT&T is cashing in on what it knows about you by selling your data to police.
Get ready for a big, new option for cord cutters
Netflix's CEO says he is not against the massive AT&T-Time Warner deal so long as Netflix will be treated the same way as HBO.
AT&T ended up buying Time Warner. But that doesn't mean Apple couldn't have.
Owning a piece of the news business is a different beast.
Sounds like a great deal... unless you're a Game of Thrones fan on Verizon.
This deal will change things for years to come.
Trump says he would block AT&T's $80 billion acquisition.
The next media behemoth is here.
T-Mobile settled with the FCC.
The Samsung Note7 story isn't getting any better.
AT&T, Verizon and Comcast are all converging in the same industries
We've got your full pricing breakdown all in one place.
The ad takes a cue from 'The Sixth Sense.'
T-Mobile is hoping to lure customers from Verizon with a new approach to data.
This is the phone to buy if you're looking for a tough phone.
A new video subscription service from AT&T will reportedly target male millennials.
And a bigger battery and progammable shortcut button.
The carrier and the shoe brand are teaming up for the Academy Awards.
AT&T wants to attract the "connected generation" with its new Hello Lab.
New customers can get unlimited data from AT&T -- with some significant catches.
America's second largest wireless carrier is finally tossing in the towel on two-year contracts.
The smartwatch is finally untethered from the smartphone, but it's not as great as it sounds.
The service, called NumberSync, will work even if your primary phone is turned off or disconnected from the network.


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Kveta Pacovská was born in Prague in 1928. In 1992, she won the Hans Christian Andersen Award, the highest and most prestigious international distinction in literature for young people, for her lifetime achievement in art. she is the author of The Sun is Yellow, also from Tate Publishing.
**Winner of the Bologna Ragazzi Special Award.


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Экономика Переходного Периода. Сборник Избранных Работ. 2003-2009
- N. G. Glavatskaya
This publication contains papers written by leading experts of the Gaidar Institute during 2003-2009. Several papers were previously published in compilations of articles written in the framework of various projects; other came out as separate articles and several papers were specially written for this publication. This book is intended for specialists in economic theory and economic policy, lecturers, postgraduate students and students in economics.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
|This book is provided by Gaidar Institute for Economic Policy in its series Books with number 1 and published in 2010.
|Contact details of provider:
| Postal: 3-5 Gazetny lane, Moscow, 125009
Phone: (495) 629-6413
Fax: (495) 203-8816
Web page: http://iep.ru/en.html
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Check in from 2:00 PM / Check out prior to 11:00 AM
Best Western Hotel Ville Platte: Find photos, reviews, information, amenities and compare prices for 2 stars hotels in Ville Platte, United States.
Best Western Hotel Ville Platte is situated in Ville Platte and is close to the area's popular attractions. It offers a swimming pool and an outdoor pool.
Hotel description
Every morning, guests can wake up to breakfast served by Best Western before venturing out to discover what the local region has to offer.
The hotel provides easy access to Alexis LaTour House. Opelousas and Turkey Creek are situated an easy drive away.
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Relief & Re-establishment activities for those affected by the Tohoku Pacific Area Earthquake
Target Area
Miyagi Prefecture, Ishinomaki City and nearby villages
Activities during June, July & August 2011
[Distribution of daily goods to temporary shelters]
Almost 7,000 temporary shelters have now been built for local residents who lost their homes in the Tsunami. JEN support this activity by distributing around 50 items, including bedding, clothing, kitchenware, hygiene materials etc. to each temporary home.
[Community Space]
As local residents move to transitional shelters or where they prefer and it is possible, back to the upper floors of their partially destroyed homes, the soup kitchens have become required less and JEN closed their Ishinomaki soup kitchen in July. To ensure that people can still gather for social activities and to help promote a community environment, 3 Community Spaces have been established. JEN has initiated some activities and seeks community input for ideas and organization going forward. Activities which JEN have organized to date, include, tea parties, yoga, massages, iPad sessions and a homework group. Volunteers assist with these activities giving their time and sometimes their expertise to support the delivery of a successful session.
JEN is planning to open more than 10 community spaces by the end of this year as part of their unique psycho-social care assistance.
[Mud busters continue]
JEN continues to coordinate volunteer activities in wider community, cleaning houses, streams and ditches, of debris and sludge. To date around 200 homes have been cleaned and many ditches cleared with almost 3000 JEN volunteers. A professional contractor volunteered his natural enzyme product and time to spray areas after sludge removal to help prevent the build-up of flies and mosquitos.
Some volunteers travel to the area for the day, or a few days, whilst others may stay longer, or return for more than one visit – coming from all over Japan as well as travelling from far away countries such as England, to lend their support. Everyone's assistance is appreciated, "Thank you from the people of Ishinomaki and from JEN", and volunteers are still very much needed …. please.
[Income Generation]
JEN has engaged with the wider community to understand that a need for assistance is required for some of the smaller fishing village areas, to support them in re-establishing their livelihoods. Volunteers have consequently been performing activities such as assistance with Oyster farming, fish-cake factory restoration, fishing net preparations and of course with ditch cleaning.
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Articles tagged "Billy Cundiff"
Divisional Trifecta: Patriots Rain On Playoff Parade
The CHFF Trifecta went 4-1 in the wildcard round and looks for the Patriots to help provide a big boost in the divisional round. Plus, the Trifecta looks at the Saints chances in Seattle.
Slack Lines, Week 16: A Snowball's Chance in Hell
Baby, it's cold outside! Tepid leader Luke Warm taunts the field, Matt leads an ill-fated Pickett's Charge of pigskin prognostication, Nick likens Tony Romo to a loveable mop-top, Jerry fails to live up to Dad, Beau & J offer nothing, and ghastly gambling losses ruin Christmas for all their children again this year.
NFL Bottom Line: Stats That Defined Each Week 14 Game
Justin Henry breaks down all of the Week 14 action, including the Philly blizzard, the thinning of the NFC herd, and the crushing of Carolina
Patriots 34, Broncos 31: The Liveblog Novella
Colonel Comey tracked every minute of "the greatest, longest, coldest, weirdest game you'll ever see" from the Gillette Stadium press box. Read all 3,168 words, including "wow," "holy s---" and more.
New Orleans Saints, San Francisco 49ers Roll In Sunday Preseason Play
A look at the results of Sunday's preseason games, as well as the rest of the penultimate preseason slate.
Tom Brady And The Patriots Look For Sixth Super Bowl
Only one thing is better than beating a team that beat you the last time you met. And that's beating that team to go to the Super Bowl.
Bill Belichick 18-7 Postseason Record Trumps John Harbaugh (7-4)
Bill Belichick is 18-7 in the postseason and 5-2 in his career against the Baltimore Ravens.
Peyton Manning's 9-11 Playoff Record Is a Call for Help
Think you can sum up Peyton Manning's playoff career by using his 9-11 record against him? Scott Kacsmar brings only the facts on Manning's eight one-and-done postseasons. Can you handle the truth?
- Play Fantasy Football in Seconds with Fantasy Spin Quick Pick
- Panthers Better Than Falcons in 17 of 22 Quality Stats
- Steelers-Seahawks tight statistical showdown
- Patriots, Panthers Have Each Faced Just 1 Quality Opponent
- New England Heads to Denver Dominant in Quality Stats Battle
- Cardinals, Patriots Top 2 in Mother of All Stats, Passer Rating Differential
- Super Bowl XLIX Prop Bets: Full List
- Super Bowl 49 Game Capsule: Patriots @ Seahawks
- Awesome: Must-see Super Bowl Hall of Shame Infographic
- Referee Bill Vinovich Gets The Nod For Super Bowl 49 -- Balls


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Location :Central
Avenida Infante Sagres, 143, 8125-157 Quarteira, Algarve, Portugal
Cleaning Service excellent.. Booked for B & B only and although something for everyone to eat, eggs were not cooked through scrambled or fried. Food was cold so glad we did not go full board. Reception staff very helpful and professional. Unfortunately no tea coffee making facilities or fridge in the rooms and had to purchase any food /drinks even water @ 2.50 euro a litre bottle within the hotel as stated in hotel booklet. Lovely upgraded hotel stay but 4 days of storm with not much to do not the hotel fault.. Location and view of beach excellent. Almost like you could touch the water. Great place for younger children with no expensive distractions in Quarteria but plenty bars/ snacks for parents. Best of any 3 stars I've ever stayed in before. Spotless Environment and pool secluded.
5/5 Standard of room
4/5 Facilities
0/5 Quality of food
5/5 Service
3/5 Location
3/5 Value for Money
No hesitation to stay again. No hesitation to recommend to friends.
5/5 Standard of room
5/5 Facilities
0/5 Quality of food
5/5 Service
5/5 Location
5/5 Value for Money


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Message from a Man in Black…to a Man of Hate
I love this video – posted to YouTube around 5 months ago… it's a message from one Hassidic Jew (representing so many others) to a man of hate (and to so many like him). It was posted before the Jewish holiday of Purim…
Purim is the story of a Persian king, his right hand man who wanted to kill the Jews, a Jewish man and his niece, who becomes the queen. An evil plot… unraveled at the last moment, twisted around to destroy the one who created the plot. It is about justice in the end, but more, it is about the Jewish people and where we put our faith. It is why we defeated Haman, that ancient Persian… and why we will defeat his ancestors – the followers of Ahmadinejad… and today's "moderate" Iranian president who joined his outgoing colleague just days ago in wishing Israel off the face of this world.
Ari Lesser – you're great! I hope this video reaches around the world…
Visit A Soldier's Mother.Paula Stern
About the Author: Paula R. Stern is CEO of WritePoint Ltd., a leading technical writing company in Israel. Her personal blog, A Soldier's Mother, has been running since 2007. She lives in Maale Adumim with her husband and children, a dog, too many birds, and a desire to write.The author's opinion does not necessarily reflect the opinion of The Jewish Press.
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Imported and Older Comments:
Wow. That put a smile on my face and fed my spirit. Thanks.
Wow. That put a smile on my face and fed my spirit. Thanks.


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Apple iPhone 4G Revealed [Update 3] So it's all over bar the wailing and screaming. It turns out that Gizmodo had this iPhone 4G prototype for a week. They bought it for US$5000 from a guy who "found it in a bar". Apparently it had iPhone OS 4.0 on it at that point, but was quickly disabled by Apple so … Read More
Apple's Second Generation iPad Will Use OLED Display?
And you thought you were safe from iPad rumors until June! AppleInsider is reporting the first of the next generation iPad rumors today. The rumor, which originated with the DigiTimes in Taiwan, states the next generation iPad will use an OLED display. Whether OLED will be offered as an upgrade to the existing IPS screen or as a complete replacement … Read More
Apple's Next iPhone 4G Revealed. Real or Fake [Update 2]
Well, give me enough rope and I'll hang myself! I was positive this "lost" iPhone 4G was a hoax. But a new twist in the iPhone 4G San Jose Bar fiasco has unfolded today. Engadget have come back blazing with all guns and a plethora of videos and teardown images for a device they are absolutely certain is an Apple … Read More
X2 Football 2010 for iPhone Teaser Trailer Now Available
X2 Games today uploaded a video of an early glimpse of their upcoming football title for iPhone and iPod touch called X2 Football 2010. We recenty published more details about this new title here. X2 Football 2010 will feature the all new 'Dream Team Mode', over 150 national teams, 10 national leagures and online mutliplayer features. In the Dream Team … Read More
Home 3D for iPhone. Makes Designing Your Dream Home a Breeze
Home 3D Rating: Makes Designing Your Dream Home a Breeze! House makeover shows are huge on TV at the moment, they aren't just on their own dedicated channels but are on the main stream channels too and that is simply because they are extremely popular. Hoping to catch in on some of that popularity are Black Mana Studios with their … Read More
Alice in Wonderland iPad Book. Beautiful Representation of the Classic Novel
Alice for the iPad Rating: A Beautiful Representation of the Lewis Carroll Classic Novel! One of the selling points of the iPad was it's ability to act as an eReader and the iBook Store was released to sell books to be read on the iPad. While the iBook Store is packed to the virtual ceiling with books they are all … Read More
PixelMagic for iPad. Mobile Photo Editing Application. App Review
PixelMagic Rating: A Great Mobile Photo Editing Application! PixelMagic is a professional photo editing application for the iPad which enables you to edit and manipulate your photo's using the large screen of your iPad. The irony of this is the fact that the iPad itself doesn't have a camera so you'll have to get any pictures you want to edit … Read More
Apple iPhone 4G Revealed [Update]
I have to say I had my doubts when I saw the pictures of the "iPhone 4G" being passed around the web in the last 24 hours. Firstly the image had popped up on Twitter a while back from a different source : [twitpic] But also it was simply such an awful overall design that it could only, at best, … Read More
Apple Patents iPhone E-Ticket System
Apple is essentially famous for two things; great products people enjoy using and creating news by filing patents. Apple is probably one of the most prodigious patent filers in all of Silicon Valley. A whole subset of Apple watchers has grown up around trying to discern the viability of the patents granted to Cupertino. Recently PatentlyApple detailed one of the … Read More
Instaviz – A flowchart tool for the iPad, iPhone and iPod Touch
Instaviz Rating: The best way to describe Instaviz for those who don't know about it is the description on the company's own website : Instaviz is an iPhone and iPad application that turns roughly sketched shapes and lines into beautifully laid-out diagrams. Instaviz uses Recog, a new shape recognition engine. Trained on over 2,500 sketches drawn by real users, Recog … Read More
Stranded: Mysteries of Time. Enjoyable RPG. iPhone Game Review
Stranded: Mysteries of Time Rating: An Enjoyable RPG let down by it's flawed controls! It seems that not a week goes by without Glu releasing a game to the App Store and their latest release is Stranded: Mysteries of Time an adventure RPG in a land of mysterious and more importantly dinosaurs! You play Dr Alex Howells on his adventures … Read More
All of Wikipedia Available Offline on iPhone/iPad at a Price!
AllofWiki Offline Rating: Information is power and in this fast paced society fast access to that information is equally important. The online 'bible' of information at the moment is Wikipedia, but the trouble with Wikipedia is you have to have access to the internet to use it and as we know there are occasions where there is no coverage for … Read More
Apple iPhone 4G / HD Revealed?
Apple might be releasing a new iPhone 4G / HD this summer. It will probably be released on June 22nd during Apple's WWDC 2010. The only real surprises left are the specs, appearance, and pricing of the new unit. Now, thanks to something lost and found on the floor of a bar, we may have our first look at the … Read More
AT&T holiday block may signal Apple iPhone 4G launch dates
As in previous years multiple sources are confirming that AT&T has put an unusual block on staff holidays for this year. In previous years the only reason for a holiday ban like this from AT&T is for an Apple iPhone launch. The interesting thing is that this year the ban is in June. Which signals that perhaps the iPhone 4G … Read More
Skies of Glory: Battle of Britain. Arcade Combat Flight Game Review
Skies of Glory – Battle of Britain Rating: An Arcade Combat Flight Game that is full of Intensity! I've always liked the idea of flight simulator games, from the early arcade incarnation of Afterburner to the complex realism of Microsoft Flight Simulator the idea of being able to fly a plane has always appealed to me. In reality though I've … Read More


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iHerb Customer Reviews
Savings of: $8.53 (24% off)
heaven in a bar.
Posted by stephd on Apr 04, 2012
These are so delicious. I love the flavor -- sweet yet savory, with a good chew (but not so jerky-like that it wears out your jaw!) I'd choose these over a grain/soy-based bar ANY day of the week. I do wish they cost a little less so I could eat them more often, but I understand that Tanka is more of a small, artisan company, not a mass-production outfit. Highly recommend these to anybody looking for a natural, low-carb, gluten-free, Paleo-friendly snack.
Posted by Reviewer3033844 on Dec 29, 2011
I love jerky, but Tanka Bars are much better than ordinary jerky. They are soft, moist and the cranberries add a touch of sweetness. Just one is all I need for breakfast and I feel satisfied all morning. Iherb has the best prices for them, so I will be a regular customer.
Wonderful product
Posted by Reviewer1227426 on Nov 10, 2011
These Tanka bars are terrific. I cary one with me every where I go. Since I am diabetic, these are great for quick nourishment. I highly recommend them.
Yummy travel food!
Posted by Reviewer1873301 on Dec 21, 2011
I eat Tanka bars as a meal or snack. They are gluten and dairy free and make great travel food! My order arrived quickly and in perfect condition. Thank you!
Tanka Bar Awesome
Posted by Reviewer2076104 on Sep 20, 2011
Tanka Bar, Buffalo Cranberry bar is an excellent addition to hiking/biking/paddling nutrition - when you are tired of the same old energy bars this is an excellent substitute.
A great shot of protein and yummy too.
Posted by Reviewer3041182 on Aug 12, 2012
A great shot of protein and yummy too.
Items 1-6 of 6 total


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Novotel Yangon Max 호텔
459 Pyay Road, Kamayut Tsp
459 Pyay Road, Kamayut Tsp
Mingalabar! Welcome to a prime destination for business travelers and tourists alike. Feel at home with our friendly, professional team and enjoy many great facilities. I hope to get the chance to meet you soon!Mr Philippe BATTLE 호텔 매니저
Indulge yourself in 5-star luxury a 20 minutes' drive from Yangon International airport at Novotel Yangon Max. Contemporary design with Myanmar accent and modern accessories make your room a tranquil retreat. Cool off with a dip in the swimming pool. Watch the famous Shwedagon Pagoda from the pool deck while sipping a cocktail at the Pool Bar.
Myanmar is a truly fascinating and unique destination with the spirituality of Buddhism beliefs and some of the most charming people in Asia. The country has a rich culture bounded by unspoilt landscape and an abundance of natural resources.
Planet 21 참여 호텔로 서비스 산업의 지속 성장 가능을 위해 적극적으로 노력하고 있습니다.
온라인 체크인: 호텔 도착 전 온라인 체크인으로 객실이 미리 준비되는 서비스
빠른 체크아웃: 체크아웃 시 간단하게 객실 키를 반납하는 서비스
온라인 체크인: 호텔 도착 전 온라인 체크인으로 객실이 미리 준비되는 서비스
빠른 체크아웃: 체크아웃 시 간단하게 객실 키를 반납하는 서비스
459 Pyay Road, Kamayut Tsp
전화: (+95)1/2305858
팩스: (+95)1/2305879
Novotel Yangon Max satisfies the needs of business travellers and leisure travellers on holiday with their family. Accommodation options include Standard, Twin and Family rooms.
Large, well-designed suite with one king bed & separate living area, rainshower & bathtub, scale, sofa, hair dryer, minibar, iron & ironing board, 40" LCD TVs, work desk, WiFi. Stay on executive floor, access to Premier Lounge. Up to 2 adults and 1 child.
Modern spacious room with one king bed or 2 single beds, 40" LCD TV, sofa, hair dryer, mini bar, iron & ironing board, iPod dock, rainshower or bathtub, scale, work desk, WiFi and coffee machine. Access to Premier Lounge. Up to 2 adults and 1 child.
Modern room with one king bed or 2 single beds, 40" LCD TV, sofa, hair dryer, mini bar, iron and ironing board, tea/coffee, work desk, WiFi access. Up to 2 adults and 1 child.
Enjoy a true experience 24h/24. Fresh meals prepared in front of you, choose from a large choice of Asian and international specialties, try "a la minute" cooking... You will bathe in European and Asian influences thanks to stylish materials.
The Chinese Restaurant offers traditional Chinese cuisine inspired by Cantonese influences with other local delicacies also available. It has a dining room and 3 private rooms.
The French Restaurant offers a refined yet authentic French cuisine in a relaxed atmosphere. It has a dining room, 3 private rooms and 3 open terraces.
The bar ideal for chilling out and meeting friends after busy day.
Enjoy simple & authentic cuisine inspired by global or local culinary themes: Italian pasta, American burgers or Spanish tapas. Our ingredients are local products: much better for the taste buds... and the planet.
The Pool Bar offers a selection of healthy beverages, cocktails and snacks. Chill by the pool, while enjoying a stunning view of the Shwedagon Pagoda.
해당 호텔 예약 시:


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First Looks: Sony Ericsson Aspen
As one of the rare few Windows Mobile and one of Sony Ericsson's Greenheart devices available in 2010, the Sony Ericsson Aspen marries both touch screen technology with a physical QWERTY keyboard. Here's our thoughts on this eco-conscious device.
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Product & Brand Information
- Item # 403149
- Air-mesh, synthetic and high-density foam upper
- Eight-piece skeletal rubber outsole with flex grooves
- Logo details
- Molded EVA midsole
- Padded tongue and collar with Achilles notch
- Precise-Return™ Sockliner
- Seven-eye lace closure
- Textile lining
Customer Ratings & Reviews
89% would recommend to a friend.
- write a review
Fantastic shoes!!!
I could wear these all day - and have- and my feet never ache
Love this shoe!
I have a bone spur in one of my big toes. So, I need a shoe that's roomy enough not to put pressure on that toe, while still providing adequate support. This shoe fits perfectly. It has enough cushion for taking the longer walks and when I need to be on my feet a lot. This is actually my second pair as I ordered the identical shoe several months ago and liked it so much.
Deserves 10 stars
This shoe makes me want to go walking. This is my second pair - I tried others, including another Ryka in between - and came back to Devotion. I find my knees and hips hurt less and I can keep going And I love the hot pink and lime colors together!
Love ryka's
I love the fit.
Love these!!!!
I looked for a new pair of walking shoes for a couple months. I'm pretty particular in what I want. This show is everything I was looking for. Supportive, comfortable, stylish. I actually liked them so much once I received them that I went on line and purchased a second pair in a different color
Always get the best price.
We guarantee you'll always get the lowest price. If you find a better price within 10 days of purchase, call us at 1.800.786.3141 and we'll not only match that price but give you an additional 10% of the difference! Learn more


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Calvin In Charge
(Page 6 of 82: Viewing Diary Entry 51 to 60)
[First 10 Diary Entries] Page Links: 1 2 3 4 5 6 7 8 9 10 11 [Last 10 Diary Entries]
Here a Calvin, There a Calvin!May 11th 2010 3:05 pm
[ View A Comments (9) ]
Everytime you see a cute orange kitty, do you think to yourself, self, that looks like Calvin!
Mawmee's Day Secrets!May 9th 2010 9:14 am
[ View A Comments (6) ]
It's my first Mawmee's Day at the bridge, and I wasn't sure how we celebrate it. Last night when all us Catster pals were chillaxin at The Catster Club, Catsy went up to the microphone and told us the agenda for today. She is the chaircat of the Mom's Day Committee.
An Orange Kind of Week at the Bridge!May 7th 2010 8:38 pm
[ View A Comments (13) ]
I've been carrying around my Welcome sign non-stop this week! It seems like everycat coming through the gate is orange!
It's Good to Be Calvin Re-Do Re-Do!May 1st 2010 4:12 pm
[ View A Comments (11) ]
Wowza, that jockey Calvin Borel won his third Kentucky Derby today on a horse named Super Saver. Of course, he was my pick, and I won the pool up here at the bridge!
6, 100, 4 . . . . .April 26th 2010 8:24 am
[ View A Comments (14) ]
No, I'm not talking about the magic numbers in that show Lost! These numbers are special to me today.
Sing Along!April 25th 2010 11:11 am
[ View A Comments (6) ]
99 collars around a cat's neck
Rainbow Bridge Day!April 1st 2010 10:40 am
[ View A Comments (9) ]
My pal, Rebby was talking to me a couple of weeks ago, and he mentioned Rainbow Bridge Day. I asked him about it because I didn't know anything about Rainbow Bridge Day although I did see it on the big, master calendar.
The Hunt is On!March 29th 2010 2:40 pm
[ View A Comments (4) ]
Hey, Catsters - did you know there is an Easter egg hunt going on? Well, you better get your glasses on and start looking because that Catster bunny has been hiding 20 eggs all over the place (pet pages, forum posts, blog posts, and Cats 101 articles).
Busy Day at the Bridge!March 17th 2010 8:52 am
[ View A Comments (8) ]
Happy St. Patrick's Day from the land of the rainbows! If you read Samoa's diary, you'll know that today is our 4th Catster anniversary - well, 4th for Autumn, Samoa, Violet, and me! Wowza, so much has happened in those four years, and I have some lifelong pals.
Again?March 10th 2010 6:50 am
[ View A Comments (15) ]
I stopped by the Internet Cafe this morning and saw that I was a diary pick again! I think that Diary Gal has a crush on me. Thanks to all my pals who left me rosettes for both my diary honors this week!
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