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This review is from: Superb Choice® Remanufactured ink Cartridge for HP 950XL/951XL(Black/Cyan/Magenta/Yellow) use in HP Officejet Pro 8620 Printer
Pros: Cheap ink, original HP is about 100 bucks for the set
Cons: ITS CHEAP! I bought this ink for a back up when I ordered the printer (hp 8620) because usually the ink it comes with is never full. I had the spare ink for 3 months before I needed it, i put it in and hp told me the cartridge was damaged, I tried every color and it came up with the same message. I spoke with the company, discount battery, and they told me sorry its past the 30 days and because its generic ink not all printers will work with it. My only question to that is why would you even sell the ink in the first place for this printer?
Bottom line this ink is junk and the customer service is just as bad.
Other Thoughts: Will have to eat the 40$ in ink and shipping on this oneREAD FULL REVIEW
This review is from: Google Chromecast HDMI Streaming Media Player (H2G2-42)
Pros: When it works its one of the best devices I used!
Cons: Had the device for several months and then video play back started to degrade, constant freezing and interruptions. Brought the device to my workplace and the same problem persisted, I then ruled out my wifi configuration since my workplace had a chromecast already that worked fine. This device is great when it works but its shoddy build quality and internal parts really come to light as the device didnt even last 6 months, Best part is Newegg wont let me RMA it, and Google wont do anything for me either because I didnt buy it from them.
Other Thoughts: Be careful of google products!READ FULL REVIEW
This review is from: ASUS Radeon HD 4850 DirectX 10.1 EAH4850 TOP/HTDI/512M 512MB 256-Bit GDDR3 PCI Express 2.0 x16 HDCP Ready CrossFireX Support Video Card
Pros: Great cards works well crossfired, runs way cooler than my original which is discontinued
Cons: what everyone else is saying is kinda true, i had a horrible experience with it, then i sent it to asus, they fixed now its working fine
cant change the fan speed i noticed that, it gives you an option, but there is no difference between 0% and 100%


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- Anonym
- Canada, Mann, 25-30
- Novise-nomade
- 1 Gjennomgang
I don't see how much better a hotel service can get...The staff was so accommodating, the shuttle bus was SO helpful...Not sure how I would have gotten around Denver...They refer you to great private drivers to airports...Such a convenient location..Great, great food places around. I highly recommend this place. Thank you for making my trip so memorable!
Hostelworld mobilapper
Bestill mens du er på farten med de nye mobilappene til Hostelworld.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Dec 7, 2010
|Filing date
|Aug 8, 2006
|Priority date
|Feb 21, 2001
|Fee status
|Also published as
|Publication number
|Michael W. Dae, Timothy R. Machold, Wade A. Keller
|Original Assignee
|Zoll Circulation, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (16), Non-Patent Citations (7), Referenced by (10), Classifications (8), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of copending U.S. patent application Ser. No. 10/408,617 filed Apr. 7, 2003, which is a continuation of U.S. patent application Ser. No. 09/790,249 filed Feb. 21, 2001 now issued as U.S. Patent No. 6,544,282, the entire disclosures of which are expressly incorporated herein by reference.
This invention relates generally to methods for medical treatment and more particularly to the intravascular application of hypothermia to treat acute coronary syndromes or other disorders that are treatable by inhibiting platelet activation and/or platelet aggregation and/or platelet adhesion.
As used in this patent application the terms "anti-platelet" and "platelet inhibiting" shall mean any inhibition of platelet activation and/or platelet aggregation and/or platelet adhesion.
Platelet activation, aggregation and/or adhesion are believed to play significant rolls in the pathogenesis of many vaso-occlusive disorders such as unstable angina, acute myocardial infarction, reocclusion of vessels following balloon angioplasty, transient ischemic attacks and strokes. Generally speaking, when a blood vessel becomes damaged, chemical agonists bind with certain binding sites on circulating platelets, causing the platelets to become activated. The types of blood vessel wall damage that can trigger platelet activation include perforation or injury to the vessel wall, progression of atherosclerotic plaque, the performance of some interventional procedure (e.g., angioplasty, atherectomy or stenting) which stretches the vessel wall or causes intimal tearing, or other causes. When activated, platelets interact with fibrinogen, fibronectin and other clotting factors causing them to adhere to the affected blood vessel wall and to aggregate with one another and with other blood cells (e.g., leukocytes). This activation, adherence and aggregation of platelets leads to the formation of a thrombus or blood clot.
Platelet inhibiting drug therapy (i.e., therapy that prevents or deters platelet activation and/or aggregation and/or adhesion) has been used in a wide variety of cardiovascular disease states. Some platelet inhibiting drugs, such as aspirin and ticlopidine (Ticlid™ Roche Laboratories, Inc., Nutley, N.J.) prevent platelet activation by inhibiting the agonists which cause the platelets to activate. However, each of these agonist-inhibiting drugs is largely specific to only one platelet activation pathway. For example, aspirin is believed to actively block platelet activation that occurs via a cyclooxygenase pathway but has little or no efficacy in blocking platelet activation that occurs via adenosine diphosphate (ADP). On the other hand, ticlopidine is effective in inhibiting platelet aggregation that occurs via ADP but has little or no efficacy in inhibiting platelet activation that occurs through the cyclooxygenase pathway. Other antiplatelet drugs, known as glycoprotein IIb/IIIa inhibitors, are thought to inhibit the activation of platelets by preventing binding sites located on the platelet membrane glycoprotein complex IIb/IIIa (GP IIb/IIIa) from becoming active even after the platelet has been triggered by an activation agonist. In this manner, the GP IIb/IIIa binding sites are rendered unavailable for binding with fibrinogen, fibronectin and other clotting factors, and as a result platelet aggregation, platelet adhesion or clot formation are inhibited. Examples of GP IIb/IIIa inhibitors include abciximab (ReoPro™, Centocor, Inc., Malvern, Pa.), eptifibatide (Integrilin™, COR Therapeutics, South San Francisco, Calif.) and tirofiban (Aggrast™, Merck & Co., West Point, Pa.).
One drawback associated with the use of antiplatelet drug therapy is that it can be expensive, especially when the newer glycoprotein IIb/IIIa inhibiting drugs are used. Also, as with virtually all drugs, the antplatelet drugs can cause side effects. Moreover, once antiplatelet drugs have been administered, the duration of their antiplatelet action can last for as long as four to six weeks. The resultant ongoing platelet inhibiting effect can be problematic in some cases, such as where some hemorrhage occurs or where a decision is made to subject the patient to surgery or some other invasive procedure, during or after which control of bleeding may be highly desirable. In this regard, as explained in the following paragraphs, the inability to rapidly reverse the effect of antiplatelet drugs can be particularly problematic in patients who suffer from certain acute cardiovascular require immediate treatment for acute coronary syndromes, such as unstable angina or non-Q wave myocardial infarction (MI), but who may subsequently be required to undergo cardiac surgery or another invasive procedure wherein control of bleeding is desirable.
Accute Coronary Syndromes: Unstable Angina and Non-Q Wave MI
Unstable angina, also referred to as "accelerating angina", "new-onset angina" or "progressive angina" is often characterized by a) chest pain that persists even in the absence of exercise, b) an increase in the severity, frequency, or duration of anginal chest pain, and/or c) the onset of anginal pain a lower levels of exercise than before. It has been reported that unstable angina occurs at some time in the lives of approximately 6 out of 10,000 people. Unstable angina typically arises in patient's who have a history of stable or exercise induced angina due to the presence of atherosclerotic plaque in one or more of the patient's coronary arteries. Non-Q-wave MI is a condition in which a blockage within a coronary artery causes a mild MI. A more serious MI often follows the occurrence of a non-q wave MI. In fact, patients who suffer from a non-Q wave MI are considered to be at even higher risk for death than individuals with unstable angina.
Both unstable angina and non-Q wave MI fall into a category of serious, life-threatening emergency conditions known as acute coronary syndromes. Both the onset of unstable angina and the occurrence of non-Q wave MI can be attributed to the rupture of a coronary atherosclerotic plaque. The rupture of the coronary atherosclerotic plaque in turn causes platelets to aggregate and blood clots to form, thereby converting the prior relatively stable narrowing of the coronary artery into an unstable ("high-grade") occlusion that severely limits blood flow to a region of the heart muscle, even when the patient is at rest.
Patients with acute coronary syndromes, such as unstable angina and non-Q wave MI, run a high risk of a fatal or non-fatal heart attack. These acute coronary syndromes require immediate hospitalization and the prompt administration of initial stabilizing treatment is a critical first step in preventing a possibly fatal heart attack from occurring. The goals of such initial stabilizing treatment is to reduce the severity of the acute symptoms and to prevent the situation from evolving into a full blown MI or potentially fatal cardiac arrhythmia. The immediate treatment often includes the administration of drugs that prevent or deter platelet aggregation or blood clotting, such as aspirin, heparin, or platelet inhibiting drugs as discussed in more detail herebelow as well as other agents such as nitroglycerin (often by paste or intravenously) beta-blockers, calcium channel blockers, antianxiety medications, and medications to control blood pressure and abnormal heart rhythms.
After the drug therapy has been initiated, the patient may be observed to determine if the condition will stabilize as a result of the aggressive medical management. If the patient does not stabilize, the patient will typically be evaluated to determine if CABG (coronary artery bypass grafting) surgery, PTCA (percutaneous transluminal coronary angioplasty) or some other surgical or interventional procedure is indicated. If surgery or an interventional procedure is indicated and the patient is otherwise a candidate for such surgery or intervention, the patient may then be taken to the catheterization lab for a PTCA or to the operating room for a CABG. In these patients the presence of previously administered platelet inhibiting drugs (i.e., drugs that inhibit platelet activation and/or aggregation and/or adhesion) can be a problem.
Transient Ischemic Attacks:
Another condition that may result from platelet activation, aggregation and/or adhesion is known as a transient ischemic attack (TIA). A TIA typically lasts from a few minutes to a few hours. TIA's are caused by interrupted blood flow to a part of the brain, resulting in neurologic symptoms such as slurred speech, dizziness, double vision, or weakness in a limb. The occurrence of a TIA indicates that the patient is at a significant risk of undergoing a full-blown ischemic stroke, potentially resulting in permanent brain damage or death. The rapid induction of platelet inhibition during or after the occurrence of a TIA may help to minimize the risk that the patient will suffer a full scale embolic stroke. However, after more definitive diagnostic tests are performed it may be determined that the patient is a candidate for an interventional or surgical procedure designed to alleviate blockages in the carotid or cerebral vasculature or that the cause of the patient's symptoms is not, in fact, a TIA but rather a small localized area of bleeding in the patient's brain. In such instances, it would be highly desirable to be able to cease or reverse any platelet inhibition therapy that has begun, but such cessation or reversal of the platelet inhibition may take as long as weeks (e.g., 4-6 weeks).
Thus, in view of the foregoing, there exists a need for the development of a platelet inhibiting treatment that may be rapidly administered to a patient who has suffered an acute coronary syndrome (unstable angina or non-Q wave MI) or a TIA, but which can be rapidly discontinued or reversed if it is no longer indicated, such as when the patient is selected to undergo an invasive interventional or surgical procedure (e.g., PTCA or CABG) where a risk of untoward bleeding is identified.
The present invention provides a method for treating an acute coronary syndrome (i.e., unstable angina or non-Q-wave MI) or TIA or otherwise causing platelet inhibition (i.e., prevention or deterrence of platelet activation and/or platelet aggregation and/or platelet adhesion) in a human or veterinary patient. In general, the method comprises the steps of a) diagnosing the acute coronary syndrome or other disorder wherein platelet inhibition is a desirable therapeutic objective, b) placing a heat exchange apparatus in heat exchange proximity with the patient's blood and c) using the heat exchange apparatus to cool the patient's blood to a temperature at which the desired platelet inhibition occurs. The heat exchange apparatus may be, for example a heat exchange catheter with a heat exchange region placed in the vasculature of the patient so that it directly exchanges heat with the blood flowing over the heat exchange region. Alternatively it may be a heat exchange catheter having a heat exchange region placed in the esophagus of a patient and exchange heat with blood in the aorta through the esophageal and aortic walls. It may even be an enhanced method of cooling blood through the skin of the patient, provided that whatever heat exchange method is used is fast and efficient enough to effect a reduction of blood and tissue temperature sufficient to inhibit platelet activation sufficient for the thearapeutic use here described.
In humans, blood flowing in heat exchange proximity to the heat exchange apparatus may be cooled to a temperature of less than 36° C. and typically in the range of 32° C. to 36° C. The temperature of the blood and/or the target tissue will be reduced to therapeutically sufficient levels fairly fast, generally in less than 3 hours, and with intravascular hypothermia applied for the purpose of treating an acute coronary syndrome, typically less than 15 minutes after the catheter is placed and begins cooling. The patient's blood may be maintained at the cooled temperature for any period of time desired, but typically such treatment will be maintained for a period of time from approximately 1 hour to approximately 3 days. Specifically, for patients being treated for unstable angina, the hypothermic treatment will typically be maintained for approximately 1 to 6 hours.
Further in accordance with the invention, the foregoing method of causing platelet inhibition may be performed in patient's who are suffering from unstable angina, non-Q wave MI and/or TIA's. The hypothermia-induced platelet inhibition caused by this method may be maintained until the patient either a) spontaneously stabilizes so as to cause platelet inhibition to be no longer indicated, b) becomes stabilized by medical therapy which may or may not include platelet inhibiting drugs and/or c) undergoes an interventional (e.g., PTCA, atherectomy, etc.) or surgical (CABG) procedure that obviates the need for continued platelet inhibition.
Further in accordance with the invention, the foregoing method of causing platelet inhibition by hypothermia may be performed as an alternative or stand-alone treatment or may be combined with other platelet inhibiting therapies or drugs, such as aspirin; non-steroidal antiinflamatories; ticlopidine; anticoagulants (e.g., heparin or warfarin); GP IIb/IIIa inhibitors (e.g., abcixmab or tirofiban) or any possible combination thereof. The hypothermic platelet inhibiting treatment of the present invention, when used in combination with platelet inhibiting drugs, may allow for a desirable reduction in the dosage(s) of the platelet inhibiting drugs used, thereby avoiding drug-related side effects or facilitation faster clearance and termination of the effect(s) of such drug(s) after cessation of drug treatment.
Further aspects and particulars of the present invention will become apparent to those of skill in the art upon reading and understanding of the detailed description and examples set forth herebelow.
The following detailed description is provided for the purpose of describing only selected embodiments or examples of the invention and is not intended to describe all possible embodiments and examples of the invention.
A. General Method for Hypothermic Platelet Inhibition
With further reference to
Furthermore, as shown in
The use of the intravascular heat exchange apparatus in the present invention generally permits hypothermia to be induced more rapidly and with substantially greater control than by noninvasive means such as wrapping the patient in a hypothermia blanket. The temperature to which the patient is cooled to effect the desired platelet inhibition is typically below about 36° C., and preferably in the range of approximately 32 to 36° C. In this invention, either whole-body hypothermia or partial-body hypothermia may be used. When whole-body hypothermia is used, the patient's core body temperature may be monitored and maintained at the desired platelet inhibition temperature. When partial-body hypothermia is used the temperature of a desired organ, limb or anatomical portion of the body will be monitored and maintained at the desired platelet inhibition temperature. Concurrently with the hypothermia, the patient may be anesthetized or may receive medications or other therapy to prevent or lessen shivering or discomfort due to the hypothermia. Examples of medications that may be administered to minimize shivering or discomfort during the hypothermic treatment are described in PCT International Application No. PCT/US00/20321. The specific drugs used to prevent shivering may include meperidine, buspirome, dexmedetomidine and/or combinations thereof. In the alternative, where it is undesirable to administer anti-shivering drugs, the patient's body temperature may be maintained blow normothermia (to achieve some platelet inhibition) but above the shivering threshold, which is typically about 35-35.5° C.
In accordance with the invention hypothermia may be administered as the sole platelet inhibition treatment, at least for a period of time sufficient to allow physicians to fully evaluate the patient's condition and to reach an appropriate decision regarding the initiation of platelet inhibiting drug therapy. In other instances, it may be desirable to administer intravascular hypothermia in accordance with this invention concurrently with the administration of platelet inhibiting drugs or other platelet inhibiting therapies so as to speed the onset of the desired platelet inhibiting effect, to reduce the dosages of platelet inhibiting drugs or other platelet inhibiting therapies required, or to otherwise improve the efficacy or reduce the toxicity of the platelet inhibiting treatment being used.
The application of hypothermia in accordance with this invention may, in addition to effecting direct platelet inhibition, simultaneously reduce overall tissue damage to an affected region. For example it may reduce blood vessel wall inflammation or microvascular injury thought to serve as a focal point for adhesion of platelets or thrombus formation. This antiinflamatory or vessel-wall-protecting effect that accompanies the anti-platelet effect of intravascular hypothermia may not be realized with anti-platelet drug therapy alone. Further, the application of hypothermia may, simultaneously with reduction of platelet inhibition, protect the target tissue in other ways. For example, hypothermia has been found to be generally myoprotective (i.e., protective of muscle cells against damage from insults like hypothermia or ischemia) and if intravascular hypothermia is applied to the blood in the IVC immediately before the blood enters the heart, it might simultaneously provide protection against damage by platelet activation and provide protection against damaging chemical cascades such as repurfusion damage to cell membranes. Likewise, hypothermia has been shown to be generally neuroportective, and if anti-platelet hypothermia is applied as a treatment for TIA's, the hypothermia might simultaneously protect the brain tissue against damage by excitatory amino acids, destructive free radicals and the like in addition to the protection for the direct damage done by activated platelets.
B. A Preferred Intravascular Heat Exchange Catheter System
Referring to
The catheter is attached at its proximal end to a hub 78. At the hub, the guide wire lumen 56 communicates with a guide wire port 80, the inflow lumen 52 is in fluid communication with an inflow port 82, and the outflow lumen 54 is in communication with an outflow port 84. Attached at the hub and surrounding the proximal shaft is a length of strain relief tubing 86 which may be, for example, a length of heat shrink tubing. The strain relief tubing may be provided with suture tie-downs 88, 90. Alternatively, a butterfly tie-down 92 may be provided. (See
Between the strain relief tubing 86 and the proximal end of the balloon 74, the shaft 50 is extruded with an outer diameter of about 0.118 inches. The internal configuration is as shown in cross-section in
At the necked down location 94, a proximal balloon marker band 102 is attached around the shaft. The marker band is a radiopaque material such as a platinum or gold band or radiopaque paint, and is useful for locating the proximal end of the balloon by means of fluoroscopy while the catheter is within the body of the patient.
At the location marked by the marker band, all four lobes of the balloon are reduced down and fastened around the inner member 67 in a fluid-tight seal. This may be accomplished by folding the outer lobes of the balloon 58, 60, 62 down around the inner lumen 64, placing a sleeve, for example a short length of tubing, snuggly over the folded-down outer lumens of the balloon and inserting adhesive, for example by wicking the adhesive, around the entire inner circumference of the sleeve. The inner lumen is then fastened to the shaft using a second short length of tubing. The second short length for example 1 mm, of intermediate tubing 104 is heat welded to the inside of the inner lumen. The intermediate tube has an outer diameter approximately the same as the inner diameter of the inner lumen. The intermediate tube is then slid over the shaft at about the location of the neck-down region near the proximal marker 102, and adhesive 106 is wicked into the space between the inside of the intermediate tubing and the outer surface of the shaft 50. A similar process may be used to attach the distal end of the balloon, as will be described, except that the distal end of the balloon is attached down around the guide wire extension tube 98 rather than the shaft.
Just distal of the proximal balloon seal, under the balloon within the inner lumen, an elongated window 108 is cut through the wall of the outflow lumen in the shaft. Along the proximal portion of the balloon above this window, five slits, e.g. 110, are cut into the common wall between each of the outer lumens 58, 60, 62 and the inner lumen 64. Because the outer lumens are twined about the inner lumen in a helical fashion, each of the outer tubes passes over the outflow lumen of the inner shaft member at a slightly different location along the length of the inner shaft and, therefore, an elongated window 108 is cut into the outflow lumen of the shaft so that each outer lumen has at least one slit e.g. 110 that is located over the window in the shaft. Additionally, there is sufficient clearance between the outer surface of the shaft and the wall of the inner lumen to allow relatively unrestricted flow of heat exchange fluid through all 5 slits in each outer lumen, around the shaft, and through the elongate window 108 into the outflow lumen 54 in the shaft 50.
Distal of the elongated window in the outflow lumen, the inner lumen 64 of the four-lumen balloon is sealed around the shaft in a fluid tight plug. Referring to
Just distal of the plug, the outflow lumen is closed by means of a heat seal 99, and the inflow lumen is skived to form an opening 101 to the inner member. This may be accomplished by necking down the shaft at 96, attaching a guide wire extension tube 98 to the guide wire lumen, and simultaneously opening the inflow lumen 101 to the interior of the inner lumen and heat sealing the outflow lumen shut 101. The guide wire extension tube continues through the inner lumen, beyond the distal seal of the balloon (described below) to the distal end of the catheter 114 and thereby creates communication between the guide wire port 80 and the vessel distal of the catheter for using a guide wire to place the catheter or for infusing drugs, radiographic dye, or the like beyond the distal end of the catheter.
The distal end of the balloon 76 is sealed around the guide wire extension tube in essentially the same manner as the proximal end 74 is sealed down around the shaft. Just proximal of the distal seal, five slits 116 are cut into the common wall between each of the three outer lumens 58, 60 62 of the balloon and the inner lumen 64 so that each of the outer lumens is in fluid communication with the inner lumen.
Just distal of the balloon, near the distal seal, a distal marker band 118 is placed around the guide wire extension tube. A flexible length of tube 120 may be joined onto the distal end of the guide wire tube to provide a soft tip to the catheter as a whole.
In use, the catheter is inserted into the body of a patient so that the balloon is within a blood vessel, for example in the inferior vena cava (IVC). Heat exchange fluid is circulated into the inflow port 82, travels down the inflow lumen 52 and into the inner lumen 64 distal of the plug tube 112. The heat exchange fluid fills the inner lumen and travels down the inner lumen, thence through slits 116 between the inner lumen 64 and the three outer lumens 58, 60, 62.
The heat exchange fluid then travels back through the three outer lumens of the balloon to the proximal end of the balloon. Since outer lumens are wound in a helical pattern around the inner lumen, at some point along the length of the balloon near the proximal end and proximal of the plug, each outer lumen is located over the portion of the shaft having the window to the outflow lumen 108. There is also sufficient clearance between the wall of the inner lumen and the shaft, as illustrated in
Counter-current circulation between the blood and the heat exchange fluid is highly desirable for efficient heat exchange between the blood and the heat exchange fluid. Thus if the balloon is positioned in a vessel where the blood flow is in the direction from proximal toward the distal end of the catheter, for example if it were placed from the femoral vein into the Inferior Vena Cava (IVC) cava, it is desirable to have the heat exchange fluid in the outer balloon lumens flowing in the direction from the distal end toward the proximal end of the catheter. This is the arrangement described above. It is to be readily appreciated, however, that if the balloon were placed so that the blood was flowing along the catheter in the direction from distal to proximal, for example if the catheter was placed into the IVC from a jugular insertion, it would be desirable to have the heat exchange fluid circulate in the outer balloon lumens from the proximal end to the distal end. Although in the construction shown this is not optimal and would result is somewhat less effective circulation; this could be accomplished by reversing which port is used for inflow direction and which for outflow.
Where heat exchange fluid is circulated through the balloon that is colder than the blood in the vessel into which the balloon is located, heat will be exchanged between the blood and the heat exchange fluid through the outer walls of the outer lumens, so that heat is absorbed from the blood. If the temperature difference between the blood and the heat exchange fluid (sometimes called "ΔT"), for example if the blood of the patient is about 37° C. and the temperature of the heat exchange fluid is about 0° C., and if the walls of the outer lumens conduct sufficient heat, for example if they are of very thin (0.002 inches or less) plastic material such as polyethylene terephthalate (PET), enough heat may be exchanged (for example about 200 watts) to lower the blood temperature sufficiently to effect hypothermic anti-platelet activity, and to cool the temperature downstream of the catheter, for example of the heart, sufficiently for therapeutic inhibition of platelet activation, aggregation and/or adhesion. If the cooling catheter is left in place long enough for example for over half an hour, the entire body temperature of the patient may be cooled sufficiently for hypothermic anti-platelet activity. In this way, for example, blood to the brain and even the brain tissue itself may be cooled sufficiently for therapeutic hypothermic anti-platelet effect.
The helical structure of the outer lumens has the advantage over straight lumens of providing greater length of heat exchange fluid path for each length of the heat exchange region. This creates additional heat exchange surface between the blood and the heat exchange fluid for a given length of balloon. It may also provide for enhanced flow patterns for heat exchange between flowing liquids. The fact that the heat exchange region is in the form of an inflatable balloon also allows for a minimal insertion profile, for example 9 French or less, while the heat exchange region may be inflated once inside the vessel for maximum diameter of the heat exchange region in operation.
Automated control of the process is optional. Examples of apparatus and techniques that may be used for automated control of the process are described in U.S. Pat. Nos. 6,149,676 and 6,149,676 and co-pending U.S. patent application Ser. No. 09/138,830, the entireties of which are expressly incorporated herein by reference.
Referring now to
Now with reference to FIGS. 12 and 12A-12C, a proximal manifold of the heat exchange region 202 will be described. The shaft 206 extends a short distance, desirably about 3 cm, within the central tube 220 and is thermally or adhesively sealed to the interior wall of the central tube as seen at 250. As seen in
A fluid circulation path is illustrated by arrows in
A distal manifold of the heat exchange region 202 is shown and described with respect to FIGS. 13 and 13A-13B. The outer tubes 228 a, 228 b taper down to meet and seal against the central tube 220 which, in turn, tapers down and seals against the guide wire extension tube 272. Fluid flowing distally through the central lumen 222 passes radially outward through a plurality of apertures 280 provided in the central tube 220. The apertures 280 open to a distal reservoir 282 in fluid communication with lumens 226 a, 226 b, and a distal reservoir 281 in fluid communication with lumens 230 a, 230 b of the intermediate and outer tubes 224 a, 224 b, and 228 a, 228 b.
With this construction, heat exchange fluid introduced into the input port 240 will circulates through the inflow lumen 254, into the central lumen 222, out through the apertures 280, and into the distal reservoir 282. From there, the heat exchange fluid will travel proximally through both intermediate lumens 226 a, 226 b and outer lumens 230 a, 230 b to the proximal reservoirs 274 and 275. Fluid then passes radially inwardly through the apertures 276 and port 278 into the outflow lumen 256. Then the fluid circulates back down the shaft 206 and out the outlet port 242.
The ribbon configuration of
The deflated profile of the heat exchange region is small enough to make an advantageous insertion profile, as small as 7 French for some applications. Even with this low insertion profile, the heat exchange region is efficient enough to adequately exchange heat with blood flowing past the heat exchange region to alter the temperature of the blood sufficient for anti-platelet action and affect the temperature of tissue downstream of the heat exchange region. Because of its smaller profile, it is possible to affect the temperature of blood in smaller vessels and thereby provide treatment to more localized body areas.
This configuration has a further advantage when the heat exchange region is placed in a tubular conduit such as a blood vessel, especially where the diameter of the vessel is approximately that of the major axis (width) of the cross section of the heat exchange region. The configuration tends to cause the heat exchange region to center itself in the middle of the vessel. This creates two roughly semicircular flow channels within the vessel, with the blood flow channels divided by the relatively flat ribbon configuration of the heat exchange region. It has been found that the means for providing maximum surface for heat exchange while creating minimum restriction to flow is this configuration, a relatively flat heat exchange surface that retains two approximately equal semi-circular cross-sections. This can be seen in reference to
C. A Preferred Method for Hypothermic Treatment of Acute Coronary Syndromes:
Once a hypothermic state capable of causing the desired anti-platelet effect (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) is reached, it may be maintained by continued heat exchange with the patient's blood at the precise amount to maintain a desired temperature. This may be accomplished by means of sensing the patient's core temperature and removing more heat if the temperature begins to rise, or removing less heat if the temperature begins to fall below the desired level. Means of accomplishing this temperature maintanence with an intravascular heat exchange catheter are set out in U.S. Pat. Nos. 6,149,676 and 6,149,676, both to Ginsburg which are incorporated herein in full, and also in PCT International Application No. PCT/US99/18939 to Ginsburg et al, previously incorporated.
When it is desired to restore the patient to normal platelet activity, the platelet inhibition may be reversed, either by allowing the patient to become normothermic or optionally by rewarming the blood, perhaps with the same heat exchange apparatus that was used to induce the anti-platelet hypothermia.
Typically, the patient will be assessed in a hospital emergency room or physician's office and an initial diagnosis or clinical impression of unstable angina or non-Q wave MI will be made. Promptly after the diagnosis or clinical impression of unstable or non-Q wave MI has been reached, an intravascular heat exchange catheter, a such as (for example) the catheter 100 shown in
In unstable angina patients that undergo cardiac surgical intervention such as CABG sometimes have hypothermia during surgery as the standard of care, often induced and maintained by a blood heat exchanger in the cardiopulmonary by pass machine. In such cases, hypothermic platelet inhibition may be administered to the patient prior to the patient going on the by-pass machine, and reversed by warming after the patient has been removed from the bypass machine.
In cardiac procedures where the patient is not placed on a cardiopulmonary by pass machine, hypothermic therapy has generally not been available. In such cases, however, the method of the present invention may be employed to provide platelet inhibition by administration of hypothermia, and subsequent reversal by re-warming by use of an intravascular heat exchange catheter as described above.
Although several illustrative examples of means for practicing the invention are described above, these examples are by no means exhaustive of all possible means for practicing the invention. The scope of the invention should therefore be determined with reference to the appended claims, along with the full range of equivalents to which those clams are entitled.
|Cited Patent
|Filing date
|Publication date
|Aug 20, 1901
|Apr 8, 1902
|Lundy B Smith
|Instrument for cooling or for warming internal portions of the human body.
|Jun 18, 1991
|Sep 22, 1992
|Hyundai Electronics Industries Co., Ltd.
|Silicon layer having increased surface area and method for manufacturing
|Jan 8, 1990
|Dec 29, 1992
|Lake Shore Medical Development Partners Ltd.
|Localized heat transfer device
|Mar 16, 1992
|Sep 6, 1994
|Lake Shore Medical Development Partners, Ltd.
|Localized heat transfer device
|Oct 18, 1994
|Jan 23, 1996
|Ginsburg; Robert
|Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
|Mar 24, 1998
|Sep 28, 1999
|Del Mar Medical Technologies, Inc.
|Selective organ hypothermia method and apparatus
|Jun 23, 1998
|Aug 1, 2000
|Innercool Therapies, Inc.
|Selective organ cooling catheter and method of using the same
|Apr 21, 1998
|Oct 3, 2000
|The Regents Of The University Of California
|Indwelling heat exchange catheter and method of using same
|Aug 7, 1998
|Nov 21, 2000
|Radiant Medical, Inc.
|Method for controlling a patient's body temperature by in situ blood temperature modification
|Aug 7, 1998
|Nov 21, 2000
|Radiant Medical, Inc.
|Catheter system for controlling a patient's body temperature by in situ blood temperature modification
|Dec 15, 2000
|Mar 4, 2003
|Radiant Medical, Inc.
|Method and apparatus for regional and whole body temperature modification
|Feb 21, 2001
|Apr 8, 2003
|Radiant Medical, Inc.
|Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
|Sep 22, 2000
|Jun 24, 2003
|Alsius Corporation
|Method of managing patient temperature with a heat exchange catheter
|Aug 11, 1999
|Jan 18, 2005
|Innercool Therapies, Inc.
|Patient temperature regulation method and apparatus
|Jul 23, 1999
|Mar 2, 2000
|Alcon Laboratories, Inc.
|Intraocular lens injection system
|Jul 26, 2000
|Feb 15, 2001
|Radiant Medical, Inc.
|Method of controlling body temperature while reducing shivering
|Frelinger et al., Combined Effects of Mild Hypothermia and Glycoprotein IIb/IIIa Antagonists on Platelet-Platelet and Leukocyte-Platelet Aggregation. The Americal Journal od Cardiology vol. 92 Nov. 1, 2003.
|Frelinger et al., Combined Effects of Mild Hypothermia and Glycoprotein IIb/IIIa Antagonists on Platelet-Platelet and Leukocyte-Platelet Aggregation. The American Journal of Cardiology, vol. 92, Nov. 1, 2003.
|Michelson et al., The Effects of Aspirin and Hypothermia on Platelet Function in Vivo. British Journal of Haematology, 1999,104, 64-68.
|Michelson et al., The effects of asprin and hypothermia on platelet function in vivo. British Journal od Haematology, 1999, 104, 64-68.
|U.S. Appl. No. 09/138,830, Ginsburg, et al.
|U.S. Appl. No. 60/181,249, Keller.
|Watts, Dorraine Day. Hypothermic Coagulopathy in Trauma: Effect of Varying Levels of Hypothermia on Enzyme Speed, Platelet function and Fibrinolytic Activity. 1997. pp. 1-10.
|Citing Patent
|Filing date
|Publication date
|Feb 20, 2013
|Apr 15, 2014
|Zoll Circulation, Inc.
|System and method for leak detection in external cooling pad
|Sep 28, 2011
|Nov 18, 2014
|Zoll Circulation, Inc.
|System and method for doubled use of patient temperature control catheter
|Oct 17, 2012
|Jan 26, 2016
|Zoll Circulation, Inc.
|Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops
|Sep 28, 2011
|Feb 16, 2016
|Zoll Circulation, Inc.
|Transatrial patient temperature control catheter
|Sep 18, 2012
|Mar 15, 2016
|Zoll Circulation, Inc.
|Patient temperature control catheter with outer sleeve cooled by inner sleeve
|Oct 8, 2014
|Mar 15, 2016
|Zoll Circulation, Inc.
|Patient temperature control catheter with outer sleeve cooled by inner sleeve
|Sep 28, 2011
|Apr 19, 2016
|Zoll Circulation, Inc.
|Self-centering patient temperature control catheter
|Sep 25, 2012
|Aug 2, 2016
|Zoll Circulation, Inc.
|Self-centering patient temperature control catheter
|Nov 13, 2012
|Sep 6, 2016
|Zoll Circulation, Inc.
|Intravascular heat exchange catheter with rib cage-like coolant path
|Feb 7, 2014
|Oct 25, 2016
|Zoll Circulation, Inc.
|Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities
|U.S. Classification
|607/105, 607/113
|International Classification
|Cooperative Classification
|European Classification
|May 7, 2007
Owner name: BAY CITY CAPITAL FUND IV L.P., CALIFORNIA
Free format text: SECURITY AGREEMENT;ASSIGNOR:RADIANT MEDICAL, INC.;REEL/FRAME:019259/0289
Effective date: 20070430
|May 21, 2007
Owner name: HORIZON TECHNOLOGY FUNDING COMPANY LLC, CONNECTICU
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|Sep 6, 2007
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Owner name: ZOLL CIRCULATION, INC., CALIFORNIA
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Effective date: 20070918
|Jun 9, 2014
|Fee payment
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text:
— By Kevin Montgomery (@kevinmonty) |
Yesterday, the beloved San Francisco Chronicle published an important look at the burgeoning "hypermasculine" haircut industry in the Bay Area (loosely defined as "establishments [that are] full of pre-1930s barber chairs, hand-powered barbering tools, folksy wooden touches, straight-razor shave kits, whiskey and, of course, the signature red, white and blue barber poles.") Behind the trend are tech-savvy folks who find their barbers on Yelp (the benchmark of tech savviness), don't want to "sit next to ladies with foil in their hair," and yearn for a time when "men used to take more pride in themselves." They really want to look good!
However, it's not all about harking back to a time 'when men were men and women were in the kitchen' and there was a military draft, it's about being real. The self-described "founder" of Valencia Street's F.S.C. Barber (and curator of stunning lines) Sam Buffa explains in what could be the best line ever published in the Chronicle's 147-year history:
"This is about moving past the scraggly, long-haired hippie to something rugged and masculine and real," says Buffa, who's interrupted by a friend bringing a quiche from Tartine.
You see, "San Francisco is ready for [real haircuts] in a way it wasn't before," Buffa mansplains. "This city is not the people who used to be here."
Namely, broke pussies.
Comments (29)
Erik | [Permalink]
I don't know about the other stuff, but I refuse to get my hair cut at any place that doesn't have a barber pole.
dude | [Permalink]
A line of balding, soft skinned, pale, overfed tech yuppies wearing hoodies and baggy jeans. So rugged. So manly.
I don't think before I type | [Permalink]
All hat, no cattle.
Ted | [Permalink]
Hilarious. Every time I walk by this place it is filled with huge pussies.
Brillo | [Permalink]
this is the barbershop equivalent of that "Unionmade" store. Yuppies pretending to be working-class as a fashion choice. There are plenty of old-school barber shops all over the Mission where men go to get their hair cut. But those old-timers are really the wrong demographic. They don't fit the Appalachian-preppy aesthetic at all!
moto-waki | [Permalink]
long hairs 4ever!
@BuffBro | [Permalink]
Haha wow.
The 'barber shop' trend in the more cash-infused parts of the US and Canada is a facetious marketing layer with no authenticity or history at all. It's presented 'in the style of' old-style mens grooming but is a salon with wood floors and no free wine. Buddy's claim to the 'real' is laughable and the Chronicle gets it. Hilarious article.
If you tie your masculinity to where you get your hair cut, you've got bigger problems, but places like this are calculated to take advantage of a trend, not to actually be an old-tyme barber shop (which would be cheap as hell and not sell custom suits in the back).
media mind | [Permalink]
If the shop doesn't have a stack of nudie mags, GTFO :)
scum | [Permalink]
I have a simple style, I grow it and mow it. I let it get a little past the collar then I shave it all off.
I don't think before I type | [Permalink]
…and then for lunch I went to this kewl eatery that serves beer in a mason jar and has reclaimed wood for its floor. It's called shit n giggle.
Herr Doktor Professor Deth Vegetable | [Permalink]
fuck that hipster wanna-be barbershop.
Scott | [Permalink]
I like the idea of "barbershops" becoming more popular. That's the only place I went when I lived in the mountains.
Get a cheap hair cut and talk about sports. But $40+ for a haircut isn't a barbershop; it's a salon. There isn't anything manly about this place except for the chairs. It's a joke to even call it a barbershop.
Dan | [Permalink]
Someone needs to bring back the boxing-themed barber shop that used to be on Mission Street near 26th, that had a keg of Guinness, and all you could drink while waiting for your cut (and getting your cut– only problem was hair in your beer).
EW77 | [Permalink]
if only we could go back to the carefree days of the 20s and 40s when male style wasn't so restrictive….sigh
No more nudists!!
Real men at Real Barbershops that vote for Scott Wiener and David Campos.
zeddy | [Permalink]
Gabby's in Chicago has been reading off names from a chalk boss, cutting yuppies hair for years for $14 or so.
Gwen D'Fortuna | [Permalink]
You fancy yourself a great hero.
A spirit who can't be contained.
So, how come with all of that off-road potential,
Your car's barely stained by the rain?
—verse from, "I am an Old-Fashioned Crotchety Busybody. I am the One Who Complains.", a song I wrote in 1997
Codex | [Permalink]
Real men cut their own hair. Looking the part means your just a poser, an actor or an imposter. Flannel shirt, 1880 s mustache/beard plus tight girl pants and girl slip on shoes equals douche.
misogynistic man-hater | [Permalink]
I remember back to when I wasn't no taller than a Georgia pine-straw my pappy used to tell me, "son, you'll know a real man by the y-chromosome he carries"…..pappy sure knew a thing or two, I do say.
I don't think before I type | [Permalink]
Frame this photo and call it "Pudgy White Dudes Who Stare at Phones and Don't Converse."
Herr Doktor Professor Deth Vegetable | [Permalink]
I'd mention my favorite barber shop, but I'm worried that then I would have to wait even longer for an open chair.
Sean Logic | [Permalink]
Pretty lulzy.
LastCallSf | [Permalink]
"Buffa mansplains. "This city is not the people who used to be here." " Oh really, Buffa? I was born here. Please, tell me more about what this city is, that is, if you have time between hopping bandwagons.
chalkman | [Permalink]
Angelo's on 18th and Sanchez has a barber pole, girly mags, and uses a straight razor….$25
I occasionally think before I type | [Permalink]
It's easy to hate on this trend but I actually think it's part of a positive change in our culture. Young people with money are spending it on expensive, local services instead of buying tons of things they probably don't need. Good for the local economy, great for the environment.


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text: Thanks again :) I read an interesting Q/A in the cluster project faq : # Why is GFS slow doing things like 'ls -lr *' whereas 'ls -r *' is fast? Mostly due to design constraints. An ls -r * can simply traverse the directory structures, which is very fast. An ls -lr * has to traverse the directory, but also has to stat each file to get more details for the ls. That means it has to acquire and release a cluster lock on each file, which can be slow. We've tried to address these problems with the new GFS2 file system. Because the way rsync works, it must stat all the files and so have to create a lock for each one. Our setup is : *) all GFS are LUN on SAN (RAID 5) *) 6 web servers write to same logs file. *) One of these 6 servers writes into the the web data folder (hundreds of thousand HTML files) , all others are readers. It is in this folder that we are using rsync So what about that : 1 GFS with dlm_lock for our web log files (where all servers are writing). 1 GFS with nolock where the web data folder is located where all servers read but only one write. Sound good or .... ;-) ? Thank again Riaan van Niekerk wrote: > > > FM wrote: >> Thank you for the answers. >> >> Another bottleneck that I could have is the way I connect to the SAN >> : device mapper multipath instead of the HP officiel module. >> >> I do not not if the performance can we increase with the official >> module ? >> > > There is no SecurePath for RHEL 4 (assuming that is what you mean by > "official module". That leaves you with > a) device-mapper-multipath > b) the Emulex or Qlogic HBA-based failover. > > I have heard mostly good things about (a) even though I dont have a > lot of production experience with it myself. It seems the trend is to > move away from vendor/array and HBA-based multipathing towards > OS-based multipathing, be it Windows or Linux. > >> >> >> >> Riaan van Niekerk wrote: >>> >>> >>> FM wrote: >>>> Hello, >>>> >>>> Here is my setup : >>>> RedHat Enterprise 4 (update 3). >>>> 5 web servers connected to a 600 GB GFS (noatime) on a SAN. >>>> On the GFS : all web sites ROOTS and httpd logs files >>>> All web servers are writing to the same log. No problem here. >>>> >>>> The prob is with rsync. When writing on the GSF it is very very slow ! >>>> (40 % slower when we are lucky :) ) >>>> >>>> lots of question : >>>> *) could it be because if I have 1 GFS for the heavy write on the log >>>> and another GFS for the websites' files ? >>>> *) expect for the noatime, is there other technic to speed up GFS ? >>> >>> a) we have increased the number of GFS locks cached to bring them >>> closer in line with the number of locks in use: >>> echo "200000" > /proc/cluster/lock_dlm/drop_count >>> (not sure how much of a performance increase this got us) >>> >>> b) We have disabled quotas >>> gfs_tool settune /mnt/san quota_account 0 >>> We saw a 3 - 5 increase in performance >>> >>> c) if you are using lots of small files, look into section 5.8 in >>> the GFS manual, Data Journaling. However, >>> - I dont know how to change this for existing data on a GFS >>> - I have asked on the mailing list, and no-one seems to be using it. >>> >>>> *) Can several webserver access EXT3 FS (read only) when only on other >>>> server have RW access to it ? >>> >>> no. the RO server will get confused when things change from under >>> it, since it is not expecting things to change >>> >>>> *) is there a options to tune rsync when using GFS ? >>>> *) we are using DLM as the locking system. All servers are connected >>>> with Gb RJ45. Is DLM using the network to manage the lock. And if >>>> it is >>>> the case, could my problem come from the network latency ? >>> >>> DLM is using the network, yes. not sure about latency. We use GB >>> ethernet with RJ45/CAT5+ and have not had any problems related to >>> DLM and the network (that we are aware of). As it was explained to >>> me by Red Hat Support, DLM is extremely efficient, being able to >>> master/distribute thousands of locks per second between nodes. >>> >>>> >>>> As I said, lots of questions here :) >>>> >>> >>> and some answers. Wish I had answers to all your questions. >>> >>> greetings >>> Riaan >>> >>> -- >>> Linux-cluster mailing list >>> Linux-cluster redhat com >>> https://www.redhat.com/mailman/listinfo/linux-cluster >> >> -- >> Linux-cluster mailing list >> Linux-cluster redhat com >> https://www.redhat.com/mailman/listinfo/linux-cluster > -- > Linux-cluster mailing list > Linux-cluster redhat com > https://www.redhat.com/mailman/listinfo/linux-cluster


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this fucking cunt. she is asian, I am for some reason infatuated with asian broads.
I was outside shoveling snow and she came home at 7am.
I have this odd obsession with her, and all I can think of is that she was out fucking some dude, then had to be home early.
Oneitis sucks man. Sluts fucking suck, who is she fucking? Why does it make me sick to ask these questions. Why the fuck is my brain wired to be so fucking sick and lust after women I don't know, and I simply admire them from a far, and fantasize about how great our life would be together.
In reality she is most likely garbage, not a good match, not the princess I image, but a disease carrying, cock carousel riding, gross labial meat drapes, impatient, self serving, lustful lush type degenerate.
My brain is diseased beyond repair.
Women make me physically ill.
This is like my 5th oneitis. They keep on coming... 3 years is average.
my oneitis
Share your experiences with the opposite sex. Suggest ways to improve your success. Analyze the behavior of females in real life and online. Rant and rave about females. Show the importance of looks pertaining to attracting females and other social situations. Discuss aesthetics and the science of attractiveness. Exchange health, nutrition and looksmaxing tips. Other topics are allowed here on a case-by-case basis.
6 posts • Page 1 of 1
it's a horrible spell to be cast with, especially if they're already married. it's nice in one way because you only have to compete with the husband instead of a bunch of Chads and wealthy beta-providers, but also more dangerous. oneitis is like being addicted to a very powerful and destructive drug.
I think mine is in her 30's with no kids. She is totally post prime, but she is not fat!
My town you have no idea how much of a plus that is.
My god the women in this town are groce.
My town you have no idea how much of a plus that is.
My god the women in this town are groce.
Even if she was fucking some guy she still probably isnt in a relationship. Just ask her out already bud.
uglykunt wrote:Even if she was fucking some guy she still probably isnt in a relationship. Just ask her out already bud.
I wish... a neihbour can be so far away. Plus I'm socially retarded, and I have severe anxiety.
when I do walk outside I am terrified due do agoraphobia.
if I encountered her I would make a bad impression because my social skills turn into full retard.
Life is a whore, just pay your dues and fuck her hard
Life is a whore, just pay your dues and fuck her hard
6 posts • Page 1 of 1
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Users browsing this forum: Baidu [Spider], ConcernedBimbo, FLAYER, Google [Bot], mvp, Nevertitty, uglykunt, Yahoo [Bot] and 62 guests


text:
Wednesday, February 21, 2007
Allocating my time
I did have time to try out the Enjoy Life Snickerdoodles (a soft cookie), which I was generally OK with -- it's not a gourmet homemade cookie or anything, but it is much better than I expected it would be. Considering it's allergen-free, I'd say the company did an admirable job on this product. I'll try to write a more thorough review in the near future. Same with an assessment of Blue Diamond's Almond Thins - which I like and plan to write more about. And a few other products I wanted to mention will also have to wait a bit.
Instead, I have been in "learning mode" and "business mode" again. For the past couple years, I have basically stepped back from my normal line of business as I focused all my efforts on learning about Celiac Disease and gluten-free baking, publishing the Gluten-Free Desserts book, and promoting it. But, lately, now that the main effort behind making the book real is done - the recipes development, and the book authoring - I have been spending more time getting back in to the software and technology aspects of my life, something I have enjoyed and been involved with since I was 13 years old.
And, helping to push me back in that direction was a call I received last week from someone I know that is trying to launch a startup venture in the Technology field. After a series of discussions, I was recruited for the position of Vice President and Chief Technology Officer, which should certainly give me plenty to keep busy with for a while - oh, I forgot to mention, I said "sure".
Why not, I figured? Right now I have more time on my hands than I ever have before, and perhaps it is all that extra time that has led to feeling the entrepreneurial "itch" setting in again. I get a thrill out of building businesses, and the way I see it, there's nothing to be lost aside from some time and effort seeing if I can help launch another successful Technology company. I also really enjoy learning about all sorts of new things, from software products to business processes, so this will be a great way to stimulate the brain cells a bit too.
I have already made it clear to others involved that I have an obligation to my gluten-free pursuits, since that is a major long-term focus for me, and a major part of my life now that I must stick to a gluten-free diet and lifestyle. In fact, this should be interesting as I try to make sure any company meetings I attend accommodate my dietary requirements. In fact, with time permitting, I'll try to introduce others to the gluten-free way by baking some foods to share during gatherings. I'll have a whole new set of "product testers" (or guinea pigs perhaps) available to try the latest recipes on :)
So, I may not be as active as I have been on my blogging, but I am still going to try to keep posting noteworthy gluten-free and celiac articles at least a couple times a week. And, I have been working on a neat little piece of software I plan to demo to all my readers soon -- a nice little Celiac and gluten-free news aggregator to put all the latest information on our favorite topic all in one place. I had a friend build the "guts" of the product, and I just need to wire it up and turn it on. So, look for that in the coming weeks too. I think it'll be rather useful for me and anyone else who likes to keep up on what's happening with CD and gluten-intolerance.
And, finally, we have weather warm enough here (in Cleveland) to melt some of this ridiculous accumulation of snow! In fact, I even got to stand outside without a jacket on and soak up some sunshine for a few minutes. Most excellent! Perhaps the groundhog is right and Spring will come early? I'm all for it!
7 comments:
- Sheri said...
Mike, congratulations on your new venture!
Can't wait to see this new "thing" you have planned for us.
- Wednesday, February 21, 2007 9:04:00 PM
- Jean Layton-GF Momma said...
You are an inspiration. I love that you mutual passions can join and develop into a benefit for more people that need the information that is so exhausting to find piecemeal.
Please let me know when your aggregator comes on line.
I will continue to check your blog for progress.
- Thursday, February 22, 2007 12:51:00 AM
- Lynn Barry said...
I can sense your enthusiasm via cyberspace. Congratulations! You are now going to take your spirit to educate the world about gluten intolerance to the business community and will be able to influence more lives in addition to the ones you continue to affect here. Good luck! You have and continue to help me all the time. Thanks, my friend...my first GF friend here at blogspot. :)Hugs
- Thursday, February 22, 2007 7:30:00 AM
- Mike Eberhart said...
Thanks everyone! I think I can balance both aspects of my life - you all will be the judges of that as time moves forward :)
I will certainly announce the news aggregator "thing" when it is ready. It shouldn't be too much longer if I can just get about 8 hours or so allocated to finishing it up.
- Thursday, February 22, 2007 9:12:00 AM
- Slacker Mom said...
Hello, I have been a recent reader to your blog, and I am so glad that you will keep it up. Thank you!
And, good luck with your new venture.
- Thursday, February 22, 2007 9:15:00 AM
- Mike Eberhart said...
Slacker Mom, nice to hear I have some readers :) That always gives me inspiration! Thanks.
And, as I said, the whole gluten-free thing is just too big a part of my life to ignore (since I'm "stuck" with it as we all are), so I'm undoubtedly going to still keep this blog active - though perhaps a bit slower pace than I have been, at least while during the busy times.
- Thursday, February 22, 2007 9:37:00 AM
- Meesh said...
Yippy - software for me!
Looking forward to your new chapter of your balanced life!
- Friday, February 23, 2007 2:13:00 PM


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Now Foods, 100% Cetified Organic Psyllium Powder
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This review is from: ZALMAN FG1000 Black 6 Buttons 1 x Wheel USB Wired 2000 dpi Gun Mouse
Pros: Got it for $2 if the rebate comes in.
It's different and feels solid
Buttons feel sturdy
Good responsive movement
Plug and play Windows 8/7
Girlfriend likes it
Cons: It's just weird especially searching the web
It pretty much is only good for FPS which they are advertising for
But for fast movement FPS games like COD, it seems heavy and especially heavy at the nose of the mouse. (Battlefield 3 is nice with this mouse)
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Also you need a pretty decent size mouse pad for this thing to fit on or you will always be falling off.
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Might end up getting a different mouse if I cant take it anymore. But im not going to give up so quickly (Only had it for a week)
This review is from: Corsair Graphite Series 600T Arctic White Steel / Plastic ATX Mid Tower Computer Case
Pros: Love the cable management, color, size, an looks
Cons: Nothing maybe a little heavy, but it's a big case.
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This review is from: Microsoft Windows 8 32-bit (Full Version)
Pros: Windows media center when you can use XBMC for free?
Cons: Non tech ppl. All they did was make the start menu with more graphics. This os runs on pretty much any old components and finds all the drivers during install.
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