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With a stay at Island Jewel Inn in Boracay Island, you'll be near the airport and minutes from Boat Station 3 and close to Boat Station 2. This bed & breakfast is within close proximity of Tulubhan Beach and Lagutan Beach.
Make yourself at home in one of the 10 guestrooms featuring refrigerators. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have showers and hair dryers. Conveniences include safes and in-room massages, and housekeeping is provided daily.
Pamper yourself with onsite massages or make use of the other amenities, which include complimentary wireless Internet access and concierge services.
Enjoy a meal at a restaurant, or stay in and take advantage of the bed & breakfast's room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge.
Business, Other Amenities
Featured amenities include dry cleaning/laundry services and luggage storage. A roundtrip airport shuttle is available for a surcharge.


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STOCKHOLM, Dec 28 (Reuters) - Swedish truck and bus maker Volvo said on Tuesday it won an order for 150 double-deck buses from Singapore's largest public bus operator SBS Transit. Deliveries of the vehicles will start in August 2005 and continue for 12 months, Volvo said. It did not give a value of the deal.
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Chef Unifies DevOps Automation
The automation of DevOps continues to expand as does the integration of current capabilities such as security and governance along with new features like data analytics as enterprise users ...Full Article
Cisco Rolls Software-Driven Net Framework
Cisco Systems (NASDAQ: CSCO) rolled out its new network architecture this week designed to make it easier to deploy software-defined platforms, virtualization, analytics and other digital enterprise capabilities. The ...Full Article
9 Truths IT Pros Must Live By
While every modern organization is unique, they all have one thing in common: the speed of business relies upon network performance. Communication, collaboration, and commerce can all suffer if ...Full Article
VMware Pushes Cloud Scale Up To 100K VMs With vRealize
As part of a rebranding campaign that started back at VMworld a month and a half ago, server virtualization juggernaut VMware changed the brands on its various cloud management ...Full Article
ISA Announces New Educational Track for Automation Event
This past Monday, the International Society of Automation (ISA), a global, nonprofit organization that helps members solve technical automation problems, announced ...Full Article
Paving the Way to Simulation Democratization
As globalization continues to dominate the business world, companies need to develop new and innovative products to stay ahead of the ...Full Article
Automation Alleviates China's Growing Labor Shortage
Robots have been a hot topic for countries like the United States as they push themselves to be more competitive against ...Full Article
Are Robots Really a Threat to Jobs?
For those concerned with bringing home manufacturing jobs that have moved from the United States to China, robots and other industrial ...Full Article
Is Automation to Blame for Our Economic Woes?
Despite reassurances of automation professionals throughout the industry, some experts simply aren't convinced that technological advancements in robotics and automation aren't ...Full Article
Boeing Goes Lean with Robotic Wing Painters
Taking a page from the auto industry's book, Boeing has added some high-tech workers to their Everett widebody-jet assembly plant. The ...Full Article


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Thomas W. Grenfell
ESCANABA – A loving husband and father, Thomas W. Grenfell, 86, of Escanaba, passed away at OSF St. Francis hospital on Monday, Feb. 11, 2013, from congestive heart failure.
Born on July 10, 1926, in Mellen, Wis., Tom spent his formative years in the Schaefer/Perronville area where he graduated from high school. During his stint with the Army Air Force Base Unit in Amarillo, Texas, he wedded Mary Mae Bruce, on Sept. 2, 1945.
After his honorable discharge in 1946, Tom worked for the Magnolia Oil Company as an accountant and fathered a son, Thomas R. Grenfell, who past away in 1992. Tom moved his family, including Jimmy Bruce from Mary's first marriage, back to the Upper Peninsula in 1956.
Tom and Mary operated the "Sports Bowl," a pool hall and soda fountain for 10 yeas before becoming a salesman for Montgomery Wards. Tom retired as a salesman from Heynsenn Selins in 1990.
Tom had a passion for several artistic endeavors. His flower gardens were envied throughout the county and his trap shooting prowess placed him in the "excellent" category. An avid painter, he had many western theme oils submitted as ribbon winners to the U.P. State Fair, and, his wise and savvy approach to antiquing and gun collecting is well respected. But his true love was performing traditional country and western music with his band Country Pickin' and other country bands. He was well known for playing with groups at the Amvets, local nursing homes and the coffee house.
Tom Grenfell was the son of William and Mary Grenfell of Escanaba and is survived by his wife of 67 years, Mary Mae; a brother, Jerry Grenfell (Rosie) of Escanaba; a sister, Joan McKenzie (Pete) of Escanaba; his son, Jimmy Bruce (Sally) of Escanaba; grandsons, Christopher Bruce (Elise) of Chapel Hill, N.C., Tony Bruce of Brooklyn, N.Y., Michael Grenfell of Wasilla, Alaska; and granddaughter, Debbie Koch (Steve) of Manitowoc, Wis., along with a number of great-grandchildren, nieces and nephews.
Funeral arrangements for Thomas W. Grenfell are in the most capable hands of Crawford Funeral Homes in Escanaba. Funeral services to celebrate the life of Thomas W. Grenfell are scheduled for Friday, Feb. 15, at the funeral home with visitation from 3 to 6 p.m.
The funeral service will follow at 6 p.m. with Pastor Donna Ritchee of Community Church of Christ, Gladstone, officiating.


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My Providence Full Bed is loaded with value & stylish design! Filled with classic style that complements almost any bedroom décor, you just can't go wrong with this transitional bed. It'll be money well spent & tons of money saved!
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Asian hardwood solids & Okume veneers in a beautiful espresso finish. Padded upholstered headboard & footboard.


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Energy and Green: Career and Education Opportunities in Alabama
Energy and Green: Energy Managers, including those focused on green technologies, supervise the operations of power, reclamation and recycling operations across the country. Administering programs that both use and preserve our resources, they strive to make these programs as efficient and effective as possible.
Alabama has a population of 4,708,708, which has grown by 5.88% over the past 10 years. Nicknamed the "Heart of Dixie," its capital is Montgomery, though its most populous city is Birmingham. In 2008, there were a total of 2,640,717 jobs in Alabama. The average annual income was $33,655 in 2008, up from $32,803 the previous year. The unemployment rate in Alabama was 10.1% in 2009, which has grown by 4.9% since the previous year. Approximately 19.0% of Alabama residents have college degrees, which is lower than the national average.
The top industries in Alabama include manufacturing magnetic media, asphalt shingle materials manufacturing, and perishable prepared food manufacturing. Notable tourist destinations include the Alan's Discount Music, the The Hip Hop Museum of Art, and the Birmingham Civil Rights Institute.
CITIES WITH Energy and Green OPPORTUNITIES IN Alabama
Featured Online Colleges
CAREERS WITHIN Energy and Green
Aquaculture Directors direct and coordinate, through subordinate supervisory personnel, activities of workers engaged in fish hatchery production for corporations, cooperatives, or other owners. Aquaculture Directors need to read and understand what has been read. They also need to determine which tools and techniques should be applied to solve a problem or deal with a situation.


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Fresh tomatoes in abundance – I've been planting more and more every summer just to have a big surplus to convert into tomato leather.
Portable, durable, delicious and likely pretty good for you since my recipe is a combination of tomatoes, herbs, spices, alliums and olive oil.
First a little about tools:
- I have a 9-tray Excalibur dehydrator with a timer. If you get one, don't forget dryer sheets. I got 2 sets, one for sweet and one for savory.
- Food processor or immersion blender. Both will work, but I've discovered that the immersion blender is a huge time saver and way less mess to clean up.
- I source a lot of my spices from My Spice Sage. So far the quality and service are both excellent.
Let's get started. Just so you know where we're headed, we're going to make a delicious tomato sauce and then put it in the dehydrator. Simple, yes?
I put about 13 oz (by weight) of sauce on each tray. I use about 1 lb of chopped onions, so we'll need around 7 lbs of cleaned, cored fresh tomatoes. Math.
Herbs and spices – I don't really measure. It's preferable to be a little excessive as the dehydration process knocks down some of the flavors. Exception – salt – dehydration concentrates the salt, so I do measure salt.
Mise en Place:
- 2 Tbsp Extra Virgin Olive Oil
- 2-3 nice sized cloves of fresh garlic, peeled and minced.
- Couple small palmfuls of crushed red pepper. Adjust for your heat tolerance. If you make some that's too hot for you, I'm here to take it off your hands…
- 2 medium onions, peeled and chopped. I am for about 16 oz.
- Couple nice sprigs of fresh sage, thyme, rosemary, and basil. Strip the rosemary leaves and chop with the herbs.
- 2 big palmfuls of fennel seeds. I've not yet found an upper limit for fennel seeds.
- palmful of paprika
- 2 tsp salt (could be less)
- ~7 lbs of ripe tomatoes, cored and halved
- Put a suitably sized heavy-bottomed, acid-resistant (I use stainless steel) pan on medium heat.
- Add the olive oil and crushed pepper.
- When the crushed pepper starts to sizzle, drop in the minced garlic. Saute for 30 seconds or so. Don't burn the garlic or it will be bitter.
- Drop in the onions and saute for about 20 minutes, stirring at least every 5 minutes. You're looking for a nice caramelization.
Getting there:
After the onions are soft and caramelized, add the tomatoes, herbs, spices and salt. Simmer, stirring every few minutes until the tomatoes are broken down and soft – usually about 30-40 minutes for me.
Now it's time for either the food processor or the immersion blender.
Food processor – cool before processing. Hot food and plastic are not a great combination.
Immersion blender – hot is fine, I do it right on the stove. The sauce can be a little chunky, but big pieces will result in uneven dehydration.
Taste your sauce – it'll likely seem heavy on herbs and spices and light on salt. This is OK and what we're aiming for.
Time to chill – let the sauce come down to nearly room temperature. If I'm in a hurry, I put ice cubes and water in the sink and set my wok in it.
Next – measure out ~13 oz (by weight) on your food scale, pour onto the dryer sheets, distribute to near the edges and level out. You might have to shake the tray a little to level it out. Again, you're looking for even dehydration and thick spots will take longer than thin spots.
Fill the dehydrator, set it for vegetable drying (on mine, that's about 125 degrees) and let it go. Typically is taking me about 9 hours. Check every 3 hours and rotate / shift trays. There are hotter and cooler spots in the dehydrator.
When the leather is visibly dry and doesn't smoosh when you push on it ('leathery'), it's probably done. Pull the sheets, let them rest (per your dehydrator's instructions), peel off and store.
We eat them out of hand or on in pieces on crackers and goat cheese. Sometime soon I'm going to try letting them be sauce for noodles on a backpacking trip.
Too much sauce? We pour leftovers in a silcone muffin pan and freeze them for later.
After they freeze, pop them out and put them in a bag for later.


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Anaesthetics may target ionotropic glutamate receptors in brain cells to produce their biological actions. Membrane-bound ionotropic glutamate receptors undergo dynamic trafficking between the surface membrane and intracellular organelles. Their subcellular distribution is subject to modulation by changing synaptic inputs and determines the efficacy and strength of excitatory synapses. It has not been explored whether anaesthesia has any impact on surface glutamate receptor expression. In this study, the effect of general anaesthesia on expression of N-methyl-d-aspartate (NMDA) receptors in the surface and intracellular pools of cortical neurones was investigated in vivo.
General anaesthesia was induced by intraperitoneal injection of chloral hydrate in adult male mice. Surface protein cross-linking assays were performed to detect changes in distribution of NMDA receptor subunits (NR1, NR2A, and NR2B) in the surface and intracellular compartments of cerebral cortical neurones.
Chloral hydrate did not alter the total amounts of NR1, NR2A, and NR2B proteins in cortical neurones. However, the drug reduced NR1 proteins in the surface pool of these neurones, and induced a proportional increase in NR1 in the intracellular pool. Similar redistribution of NR2B subunits was observed between the two distinct pools. The changes in NR1 and NR2B were rapid and remained throughout the duration of anaesthesia. NR2A proteins were not altered in the surface or intracellular pool in response to chloral hydrate.
These data demonstrate that subcellular expression of NR1 and NR2B in cortical neurones is sensitive to anaesthesia. Chloral hydrate reduces surface-expressed NMDA receptors (specifically NR2B-containing NMDA receptors) in these neurones in vivo.
Glutamatergic transmission is central to the modulation of normal neuronal and synaptic activity in the central nervous system. Glutamate exerts its pleiotropic roles by interacting with two classes of receptors: ionotropic and metabotropic glutamate receptors.1 The former includes three subtypes: N-methyl-d-aspartate (NMDA) receptors, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors, and kainate receptors. The NMDA receptor is broadly distributed in the brain.2,3 Upon activation of this ligand- and voltage-gated receptor, small cation ions (Ca2+ and Na+) enter cells through opened receptor channels to induce the excitatory post-synaptic current and modulate Ca2+-sensitive intracellular signalling.1,4 Each NMDA receptor is a heteromeric assembly of multiple subunits. A functional NMDA receptor is assembled of obligatory NR1 subunits and modulatory NR2 subunits, principally NR2A and NR2B.5,6 A tetrameric complex assembled of two NR1 and two NR2 subunits seems to be a prototypic model of NMDA receptors. As such, three major subtypes of NMDA receptors, that is, NR1/NR2A, NR1/NR2B, and NR1/NR2A/NR2B, are expressed in the central nervous system.
The property of NMDA receptors is determined by their subcellular localization. In brain cells, NMDA receptors are expressed exclusively in a membrane-bound form. They are bound to either the surface membrane or the membrane of intracellular organelles, including endoplasmic reticulum, Golgi apparatus, and vesicles.7 The amounts of receptors in surface and intracellular membrane compartments are determined by receptor trafficking.8–10 Under basal conditions, synthesized NMDA receptors are transported from the intracellular organelles to the surface membrane (externalization trafficking). Meanwhile, surface-expressed NMDA receptors are transported to the intracellular sites (internalization trafficking). Both externalization and internalization are integrated to control the number of NMDA receptors at synaptic sites and thereby determine the efficacy and strength of excitatory synapses.9,11 It is clear that these trafficking steps are highly sensitive to changing synaptic inputs, and are critical molecular sites for the modulation of synaptic glutamatergic transmission by a variety of extracellular stimuli.7,12
Increasing evidence indicates that the NMDA receptor is a target of anaesthetic agents in the central nervous system. By affecting NMDA receptors, anaesthetics produce some of their biological actions. However, whether anaesthetics affect NMDA receptor trafficking has not been explored. In this study, we therefore investigated the potential impact of general anaesthesia on NMDA receptor trafficking in vivo. We selected chloral hydrate as a general anaesthetic because it is the most commonly used anaesthetic for in vivo biochemical and physiological experiments in animal studies.
C57BL/6J male mice (2–3 months old) were used (Charles River, New York, NY, USA) and were individually housed in a controlled environment at a constant temperature of 23°C and humidity of 50 (sd 10)% with food and water available ad libitum. The animal room was on a 12/12 h light/dark cycle. Mice were allowed 6–7 days of habituation to the animal colony. All procedures performed were approved by the Institutional Animal Care and Use Committee (Kansas City, MO, USA) and were in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.
General anaesthesia was induced by intraperitoneal (i.p.) injections of chloral hydrate (Sigma, St Louis, MO, USA) in phosphate-buffered saline (PBS) at a dose of 400–500 mg kg−1. Anaesthesia was assessed by loss of righting reflex (LORR), and time to induce LORR was usually between 3 and 6 min. Mice were kept at room temperature for 10 min before sacrifice. In the study investigating the role of body temperature, body temperature of mice was maintained with a rectal probe and a heating plate (TCAT-2 controller, Harvard Apparatus, Holliston, MA, USA). PBS was used for control injections.
Western blot was performed as described previously.13–15 Briefly, mice were killed by cervical dislocation and brains were immediately removed. The cerebral cortex was quickly dissected on ice. Brain tissues were sonicated in a sample buffer (RIPA) containing 50 mM Tris–HCl, pH 7.5, 1% Nonidet P-40, 4% ionic detergent sodium deoxycholate, 150 mM NaCl, 1 mM EDTA, 1 mM dithiothreitol, 1 mM phenylmethanesulphonyl fluoride, 5 µg ml−1 each of aprotinin, leupeptin, and pepstatin, 1 mM Na3VO4, and 1 mM NaF. Protein concentrations were determined with a Pierce BCA Assay Kit (Rockford, IL, USA). Equal amounts of protein (20 µg 20 µl−1 per lane) were separated on NuPAGE Novex 4–12% gels (Invitrogen, Carlsbad, CA, USA). Proteins were transferred to polyvinylidene fluoride membrane (Millipore, Bedford, MA, USA) and blocked in blocking buffer (5% non-fat dried milk and 0.1% Tween 20) for 1 h. The blots were incubated in primary rabbit polyclonal antibodies against NR1 (Upstate, Charlottesville, VA, USA), NR2A (Upstate), NR2B (Upstate), α-actinin (Upstate), or actin (Santa Cruz Biotechnology, Santa Cruz, CA, USA) usually at 1:1000 overnight at 4°C. This was followed by 1 h incubation in goat anti-rabbit horseradish peroxidase-linked secondary antibodies (Jackson Immunoresearch Laboratory, West Grove, PA, USA) at 1:5000. Immunoblots were developed with the enhanced chemiluminescence reagents (ECL; Amersham Pharmacia Biotech, Piscataway, NJ, USA), and captured into Kodak Image Station 2000R. Kaleidoscope-prestained standards (Bio-Rad, Hercules, CA, USA) were used for protein size determination. The density of immunoblots was measured using the Kodak 1D Image Analysis software, and all bands were normalized to total actin amount and then to basal values. Values are expressed as percentages of basal values.
Surface receptor expression was assayed using a membrane-impermeable cross-linking agent bis(sulfosuccinimidyl)suberate (BS3), which only cross-links proteins on the surface of cells. As described previously,16,17 brains were removed after cervical dislocation. The dissected cortex was chopped into small pieces with a pair of scissors and added to eppendorf tubes containing ice-cold oxygenated artificial cerebrospinal fluid (ACSF) containing (mM) 119 NaCl, 3.5 KCl, 1.3 MgSO4, 2.5 CaCl2, 1 NaH2PO4, 26.2 NaHCO3, and 11 glucose, bubbled continuously with 95% O2/5% CO2 (pH 7.4). In some experiments, coronal slices (350 µm) were prepared using a vibratome. The cerebral cortex was dissected from the slices and added to Eppendorf tubes containing cold oxygenated ACSF. BS3 (Pierce, Rockford, IL, USA) was added (2 mM) and incubated with gentle agitation for 30 min at 4°C. The cross-linking reaction was terminated by quenching with 20 mM glycine (10 min, 4°C). The tissues were then washed four times in cold ACSF (10 min each), homogenized to obtain total protein homogenate, and analysed directly by SDS–PAGE (4–12% Tris–glycine gels, Invitrogen).
Righting reflex was assessed after administration of chloral hydrate. Righting reflex scores were evaluated according to the rating scale: a score of 0 indicated a normal right reflex; +1 indicated that the mouse righted itself within 2 s on all three trials (slightly impaired righting reflex); +2 indicated that the latency to righting was >2 s, but <10 s at the best response in three trials (moderately or severely impaired righting reflex); and +3 corresponded to the absence of righting reflex (no righting within 10 s on all three trials).18
The results are presented as means (sem) and were evaluated using a one- or two-way analysis of variance, as appropriate, followed by a Bonferroni (Dunn) comparison of groups using least squares adjusted means. Probability levels of <0.05 were considered statistically significant.
We first analysed the compartment-specific distribution of NMDA receptors in cortical neurones under normal conditions. We used a biochemical technique to isolate native NMDA receptor subunits from surface and intracellular pools in live neurones.16,19 As shown in Figure 1a, BS3-linked and -unlinked receptor proteins are readily distinguished. In BS3-treated cortical tissue, each NR1, NR2A, and NR2B subunit displayed an additional high molecular weight band. This band is much higher than a normal molecular weight band that was seen in control tissue for NR1 (115 kDa), NR2A (175 kDa), and NR2B (180 kDa) monomers. This is due to the fact that it contained BS3-linked high molecular weight receptors from the surface pool. Whereas a single strong monomeric molecular weight band from control tissue contained receptors from both surface and intracellular compartments, the normal molecular weight band from BS3-treated tissue was reduced in density because it contained receptors only from the intracellular pool. The selectivity of BS3 in cross-linking surface receptors was confirmed by the lack of its cross-linking with the intracellular proteins, α-actinin (Fig. 1a) and synapsin (data not shown). Moreover, treatment of cortical homogenates with BS3 completely eliminated the monomeric bands of NR1 (Fig. 1b). This elimination remained unchanged after co-incubation of chloral hydrate (5 mM) with BS3 (Fig. 1c), indicating that chloral hydrate itself has no impact on the cross-linking capacity of BS3.
The percentage of the three subunit proteins in the intracellular pool was determined by comparing the amount of intracellular subunits in BS3-treated tissue with the total subunit protein abundance in control tissue. Under normal conditions, about 28–39% of each subunit is intracellular [NR1, 38.6 (4.5)%; NR2A, 34.1 (3.8)%; and NR2B, 28.4 (5.9)%; Fig. 1d]. This appears to indicate that the majority of NMDA receptor proteins of cortical neurones are expressed in the surface pool under basal conditions.
We also tested surface expression of NR1 in BS3-treated cortical slices. The results were similar to those observed in the chopped small pieces of cortical tissue. This indicates that BS3 diffuses equally well in these two types of preparations.
We then investigated whether anaesthesia alters total protein abundance of NMDA receptors in cortical neurones in vivo. We found that total NR1 protein levels were not altered by anaesthesia. The amount of NR1 proteins in anaesthetized mice did not differ from that in conscious control mice [96.7 (8.3)% of control, P>0.05]. Similarly, total NR2A expression was insensitive to anaesthesia as it remained at 97.3 (5.1)% of control (P>0.05) after anaesthesia. Like both NR1 and NR2A, NR2B was not altered in its total protein abundance by anaesthesia. The total NR2B level in anaesthetized mice was 94.6 (6.2)%, which is comparable with its level in control mice (P>0.05). These data demonstrate that anaesthesia induces no significant change in total NMDA receptor subunit proteins in cortical neurones.
Although anaesthesia did not alter the total amount of three NMDA receptor subunits based on the above data, we next investigated whether anaesthesia affects subcellular expression of these proteins. We found that the amount of BS3-linked NR1 proteins was reduced in anaesthetized mice when compared with control mice treated with PBS [81.7 (1.7)% of PBS control, P<0.05; Fig. 2a]. As opposed to this loss of NR1 in the surface membrane, the level of BS3-unlinked NR1 proteins (intracellular NR1) in anaesthetized mice was increased to 134.8 (5.9)% of control (P<0.05; Fig. 2a). Owing to the parallel decrease and increase of NR1 in the surface and intracellular pool, respectively, the ratio of surface to intracellular NR1 was markedly reduced after anaesthesia (Fig. 2b). The intracellular protein α-actinin did not exhibit any change in abundance after anaesthesia (Fig. 2a). These data reveal a significant redistribution of NR1 in cortical neurones after anaesthesia.
Unlike NR1, NR2A showed no change in its abundance in either surface or intracellular pool in response to anaesthesia. As shown in Figure 2c, the NR2A level in the two compartments of anaesthetized mice did not differ from that of PBS-treated mice. As a result, the ratio of surface to intracellular NR2A remained unchanged after anaesthesia (Fig. 2d).
NR2B is another subunit sensitive to anaesthesia. After anaesthesia, the BS3-linked NR2B level in the surface pool was reduced to 74.7 (2.3)% of control (P<0.05; Fig. 2e). In contrast, BS3-unlinked NR2B proteins in the intracellular pool was enhanced to 154.9 (6.3)% of control (P<0.05; Fig. 2e). These comparable changes in opposite directions resulted in a reduction of the ratio of surface to intracellular NR2B (Fig. 2f). The data here indicate that NR2B, like NR1, underwent a significant redistribution of its abundance during anaesthesia.
Effects of a subanaesthetic dose of chloral hydrate were also tested. Injection of chloral hydrate at 100 mg kg−1 did not produce deep anaesthesia, and animals showed spontaneous body and limb movements. Similarly, no significant change in BS3-linked and -unlinked NR1, NR2A, and NR2B proteins was observed in animals injected with chloral hydrate when compared with those injected with PBS (data not shown).
Time-course studies were carried out to examine the temporal property of anaesthesia-induced changes in NR1 and NR2B proteins in the different pools. In behavioural experiments, chloral hydrate at a dose of 500 mg kg−1 induced a relatively short-lived anaesthesia as measured by the LORR over different time points (Fig. 3a). A state of deep anaesthesia was rapidly induced 10 min after drug injection as no righting reflex was observed at this time point. Animals started to recover from anaesthesia 90–110 min after injection (Fig. 3a). In separate biochemical experiments, changes in NR1 levels as manifested by a decrease in the surface pool and an increase in the intracellular pool were evident 10 min after chloral hydrate injection and remained at 1 h (Fig. 3b). These changes were insignificant between anaesthetized mice and control mice at the 2 h time point (Fig. 3b). NR2A in both pools showed no significant changes at all time points surveyed (Fig. 3c). NR2B, however, showed the same temporal pattern of changes as NR1 in both surface and intracellular pools (Fig. 3d). These data reveal the closely related changes in behavioural and NR1/NR2B responses to anaesthesia.
Anaesthesia is known to reduce body temperature.20 We next evaluated the role of body temperature in the redistribution of NR1 and NR2B during anaesthesia. Body temperature of animals was maintained at 37°C during anaesthesia. Animals were killed 10 min after injection of 500 mg kg−1 chloral hydrate for monitoring changes in NR1 and NR2B proteins in the surface and intracellular pools with BS3-cross-linking assays. We found that the BS3-linked NR1 and NR2B levels in the surface pool were reduced, whereas the BS3-unlinked NR1 and NR2B levels in the intracellular pool were elevated (Fig. 4). These data demonstrate that the effect of anaesthesia on the redistribution of NR1 and NR2B is not contributed by hypothermia.
The present study investigated the effects of anaesthesia on protein levels of all three NMDA receptor subunits in different subcellular compartments of mouse cortical neurones in vivo. We found that anaesthesia led to a significant reduction of NR1 protein abundance in the surface pool. Anaesthesia also increased NR1 protein levels in the intracellular pool. In parallel with NR1, NR2B proteins were reduced in the surface pool and enhanced in the intracellular pool. In contrast to NR1 and NR2B, NR2A was stable in both compartments in response to anaesthesia. In addition, anaesthesia did not alter total protein levels of the three subunits in cortical neurones. These results for the first time provide evidence that the subcellular location of NMDA receptors, specifically NR2B-containing NMDA receptors, in cortical neurones is subject to modulation by anaesthesia, and general anaesthesia causes a significant redistribution of the receptor from the surface pool to the intracellular pool. Of note, this study was conducted on cerebral cortical neurones. It is currently unclear if the redistribution of NMDA receptors observed in cortical neurones also occurs to other brain regions during anaesthesia. In addition, we have determined that the redistribution of NR1/NR2B was independent of the effect of hypothermia. However, the potentially confounding effects of hypotension, hypoxia, hypercarbia, and acidosis have not been investigated in the current study, and need to be evaluated in the future.
The important finding in the present work is the redistribution of NR2B-containing NMDA receptors between the surface and the intracellular pools of cortical neurones after anaesthesia. This redistribution is characterized by the loss of the receptor in the surface pool and the accumulation of the receptor in the intracellular pool. The mechanism(s) responsible for this redistribution are unclear. Presumably, the delivery process of the receptor from the intracellular organelles to the surface membrane, that is, an externalization trafficking process, is preferentially suppressed. Alternatively, an internalization trafficking process removing surface receptors to intracellular sites is selectively accelerated. Either suppressed externalization or accelerated internalization or both could cause a redistribution phenomenon characterized by the subtraction of the receptor in the surface pool in combination with the proportional addition of the receptor in the intracellular pool, whereas total receptor proteins remain unchanged.7,16 Future studies will be required to elucidate possible molecular mechanisms underlying the anaesthesia-induced redistribution of NMDA receptors.
This study did not explore the functional consequences of the reduction of surface NMDA receptors during anaesthesia. It is also unclear if the loss of NMDA receptors occurred at synaptic or extrasynaptic sites. The affected receptors could be extrasynaptic with little immediate impact on synaptic transmission. If it occurred at synaptic sites, the loss of surface NMDA receptors is believed to weaken NMDA receptor function and reduce the efficacy and strength of excitatory synapses containing NMDA receptors.9,11 With regard to cellular mechanisms underlying general anaesthesia, potentiation of inhibitory synaptic transmission seems to be a common pathway mediating many forms of general anaesthesia induced by a variety of general anaesthetics.21,22 Specifically, general anaesthetics, including chloral hydrate, augment GABAA-mediated inhibitory transmission to produce anaesthesia. A large number of reports have documented that chloral hydrate or trichloroethanol, an active metabolite of chloral hydrate within minutes of injection, potentiates the function of GABAA receptors in a manner similar to barbiturate or steroid anaesthetics in heterologous cells expressing GABAA receptors or in hippocampal neurones.23–26 In contrast to the well-defined role of GABAA receptors, little is known about a direct role of NMDA receptors in producing anaesthesia.27,28 Chloral hydrate reduced basal levels of glutamate by 70% in the striatum.29 Trichloroethanol also inhibited glutamatergic transmission in hippocampal slices.23 However, the potency of this inhibition appears to be lower than its potency for enhancing GABAA receptor-mediated transmission.23 The concentrations (1–10 mM) at which trichloroethanol inhibited glutamate receptor-mediated currents are higher than those (0.2–0.5 mM) required for producing threshold effect on GABAA receptors.23,24 Thus, the depression of NMDA receptor-mediated glutamatergic transmission may not significantly contribute to anaesthesia specifically induced by chloral hydrate, even though it contributes to anaesthesia induced by the dissociative anaesthetics such as ketamine and phencyclidine.30–32
Recently, we found that the general anaesthetic propofol inhibited phosphorylation of NR1 subunits at two specific serine sites (serine 896 and serine 897) and impaired NMDA receptor-mediated Ca2+ influx in cultured rat cortical neurones.33 We also found that propofol affected AMPA receptor phosphorylation34 and inhibited activation of extracellular signal-regulated protein kinases in hippocampal neurones.35 In this study, we revealed that general anaesthesia caused the loss of surface-expressed NMDA receptors. These new biochemical data join a large volume of early electrophysiological results to support the profound effect of various general anaesthetics on NMDA receptors.21 Although the role of depressed NMDA receptors in inducing anaesthesia remains to be defined, NMDA receptors might well contribute to some specific biological actions of anaesthetics. Future studies need to elucidate the importance of NMDA receptors in processing a specific cellular response to a given anaesthetic agent.
This work was supported by NIH grants R01DA010355 and R01MH061469 (J.Q.W.) and a grant from the Saint Luke's Foundation (Kansas City, MO, USA).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Help with Business Finance
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I have prepared a financial model for my Start-up, based on a free template from [url removed, login to view] But it turned out, that the balance sheet and the cash flow statement are not working correclty and I am not able to find the error. Therefore I am searching for an expert, who could have a look and hopefully fix the modell.
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On October 17th, Banco Santander, S.A. (NYSE:SAN) will be officially changing the name of its Sovereign Bank branches in the US to Santander. While the branches are only located in the Northeast (New York, Boston, Philadelphia, etc.), this will improve brand recognition for the company. Santander is well known in Latin America and the UK. This move may help the company attract business from foreigners living in the US.
With over 700 branches, this move is pretty significant. Santander also said it will start a more aggressive ad campaign once the move is complete. Soverign/Santander rates on loan products and CD's are generally a tad better than banks like Chase, Wells Fargo, and Bank of America.
For those bullish on housing (particularly in the UK), Santander offers another area for potential growth. In 2011, Santander was the second largest mortgage lender in the UK. By the end of 2012, the company had dropped to fifth. This was due to the company reducing its mortgage book by £10bn. In September, the UK unit announced plans to stimulate mortgage lending by offering new fee-free mortgages and making TV advertisements.
The UK Government is pushing their "Help to Buy" mortgage scheme program aimed at helping borrowers buy property with lower down payments. The Government has set aside £12bn worth of guarantees to back up to £130bn in lending. While many of the bigger banks have yet to sign on to the program, I expect this to change as more details become revealed in the next few months.
I believe Santander's stock price has been unfairly beaten down since it's linked to Spain. However, a majority of its business comes from outside of Spain. On the bright side of being linked to Spain, the Spain ETF has acted well as of late. In the two charts below, you can see the pattern of SAN and EWP are similar.
Please note that the SAN chart provided by this service seems to be off for the 2008 high price and at the end of 2009. However, you can clearly see the similar pattern. For those that love dividends, SAN is currently paying around %7.20 at these levels.
Longer term, I can see SAN moving to at least $12 challenging the 2011 highs. The stock has been on a tear as of late and I recommend initiating positions on any pullbacks.
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Spaghetti alla Carbonara
- 1/2 medium onion, finely chopped
- 4 ounces pancetta, chopped into 1/4inch cubes
- 1/2 cup cream
- 4 eggs
- 1/4 cup freshly grated pecorino plus 1/4 cup
- 1 pound spaghetti # 5 Barilla
- 4 tablespoons freshly ground black pepper
Bring 6 quarts water to boil and add 2 tablespoons salt.
Place onion and pancetta in a 12 inch to 14 inch saute pan and cook over medium heat until both onions and pancetta are translucent, about 8 to 10 minutes. Add cream and cook 1 minute. Separate eggs, being careful to keep yolks whole. Cook spaghetti according to package instructions and drain well. Put hot pasta into pan and toss over medium heat until coated. Add 1/4 cup pecorino and stir through. Remove from heat and vigorously stir in egg whites. Divide among 4 plates and top each with 1 yolk. Divide remaining grated cheese and black pepper atop each portion and serve.
Recipe Courtesy of Mario Batali
Cooking Tips
More Recipes and Ideas
Spaghetti alla Carbonara
Recipe courtesy of Tyler Florence
Spaghetti alla Carbonara
Recipe courtesy of Anne Burrell


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I'm thinking of doing this in the next week or so for my kids. But I will probably just make one that they can share instead of 3 books with the same pics haha.
No I don't but if I did I would would ether use shutterfly to make one or scrapbook one.
Our homeschool group has a committe that takes individual and group photos throughout the year. They create a yearbook and use a company to publish copies for purchase. Each family orders one if they want one.
I didn't, but it's not a bad idea!
We've done scrapbooks, i guess that's like a yearbook. But we've also done actual yearbooks through our co-op as well.
What a great idea!! I never thought about it.
I suggested we have an "open house" kind of thing for the grandparents, but DH didn't like the idea. He felt like it would be trying to justify our decision (or something like that), but I just remember being so excited to show my grandparents what we had worked on all year long when I was in school.
We keep a homeschool blog with a lot of pictures.
I have to (by law) create a portfolio for each child every year. I have always scanned and uploaded everything onto the computer, then stored it on a CDROM. I send a copy to the school, keep a copy for my records, and save a copy (keepsake) for each kid. - It has pictures, videos, assignments that were scanned onto the computer, schedules + attendance, book lists, etc.
I plan on taking the photos my daughter took this year and turn them into a book for her. If all goes well I will also turn it into an ebook for people to admire the wonderful photos she has taken.
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Industry Insights
The global 1,4-butanediol market size was estimated at USD 4.72 billion in 2013. High growth in emerging economies coupled with rising product demand from various end-use industries is expected to drive the industry over the forecast period. 1,4-BDO is an organic compound and used as an industrial solvent & cleaner and glue removers. It is a key raw material for manufacturing spandex via producing polytetramethylene ether glycol.
Butanediol can be produced by various industrial processes including propylene oxide, allyl acetate, Davy process, Butadiene process, and bio-based process. At room temperature, BDO is a colorless, odorless, and viscous liquid. It is an intermediate chemical for tetrahydrofuran (THF), polytetramethylene ether glycol (PTMEG), gamma-butyrolactone (GBL), polybutylene terephthalate (PBT), and polyurethane (PU). These chemicals are widely used in engineering plastics, fibers, medicines, artificial leather, cosmetics, pesticides, hardener, plasticizers, solvent, and rust remover.
Rising THF and spandex demand for sports apparels is anticipated to fuel the industry over the forecast period. An increasing number of sporting events such as Olympics and FIFA World Cup is expected to have a positive effect on the market for the foreseeable future. BDO is less durable than its non-synthetic counterpart, natural latex.
BDO is used to manufacture polyurethanes, which has large downstream applications such as footwear, transportation, and building & construction. Rising footwear demand, mainly in Asia Pacific and Latin America, is expected to fuel industry growth over the next six years. However, growing environmental concerns regarding the adverse impact of the product may set back the demand. This has shifted consumer preference towards bio-based products.
Stringent government regulations regarding synthetic chemicals in the U.S. and Europe are anticipated to pose a challenge to the product industry. High manufacturing costs coupled with volatile raw material prices are projected to hinder butanediol market growth
North America butanediol market revenue by product, 2012 - 2020 (USD Million)
Application Insights
Tetrahydrofuran (THF) emerged as the leading application segment and accounted for over 29% of total volume in 2013. THF is primarily used for manufacturing spandex fibers. Rising spandex demand on account of growing sports industry is expected to drive this particular segment over the forecast period.
In 2013, polyurethane market accounted for over 25% of total volume. Polyurethane is projected to be the fastest growing application segment at an estimated CAGR of 5.1% from 2014 to 2020. Rising footwear and construction industry in emerging economies such as India and China may be attributed to the fastest growth in this particular segment.
PBT accounted for 22% of total volume in 2013. It is mainly used in household electrical engineering and the production of plug connectors in the automobile industry. GBL demand is anticipated to increase primarily due to its downstream applications as a pharmaceutical intermediate, in herbicides and foundry resins. It is also used as an extraction solvent via N-methyl-2-pyrrolidone.
Regional Insights
Asia Pacific dominated the BDO industry and accounted for 50% of total volume share in 2013. It is expected to be the fastest growing market at an estimated CAGR of 5.1% from 2014 to 2020. Growing disposable income levels mainly in countries such as China and India have contributed to the growth of the regional market. High production capacities in Asia Pacific give flexibility to the manufacturers to scale up the production depending upon demand trends.
Product demand in North America was 308.4 kilo tons in 2013. North America and Europe are relatively mature markets for BDO and are expected to grow at a sluggish rate compared to other regions with high growth and are primarily driven by the growth of bio-based chemicals.
Competitive Insights
BASF and Dairen Chemicals dominate the global butanediol market share, accounting for over 38% in 2013, with BASF being the largest player at over 24%. The other main players in the market include Lyondell Chemicals, Shanxi Sanwei Group, International Specialty Products, Invista, and Mitsubishi Chemicals.
Key players in the global industry such as BASF, Purac, Myriant, Mitsubishi Chemicals, DSM, and Genomatica are focusing on developing bio-based products. Companies are investing heavily in developing bio-based routes to produce BDO. Raw materials for such courses include bio-based succinic acid and sugar that contain biomass and polyhydroxyalkanoate (PHA).
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Cardiac Education Resources
0 I want to ask - what videos/resources are you using for cardiac education teaching post myocardial infarction?
I am looking for a simple viedoe that clearly explains many of the issues and that is up to date.here are a few videos, but not on ami:
interventional cardiology
Last edit by VickyRN on Jan 2, '07here are some patient guides from university of ottawa heart institute:
target heart rate calculator- an excellent patient teaching tool from healthyontario.comJan 1, '07 by VickyRN GuidePamphlets available on:
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cardiology discharge booklet
heart failure patient information booklet
heart transplant discharge sheet
pulmonary thromboendarterectomy (pte)
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Vascular Testing and You
Abdominal Vascular Arterial Disease
Peripheral Arterial Disease
Cerebrovascular Disease
Venous Disease
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SVU Publications: Patient Education PamphletsJan 2, '07 by VickyRN Guideheart center online
excellent source of patient-teaching educational materials on a rich variety of cardiovascular subjects: articles, videos, animations, illustrations. requires registration, but registration is free.
heart-health educator
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view the video and/or illustration to help visualize how the condition occurs. after completing the course, you will have the opportunity to learn more about the topic.Jan 5, '07 by VickyRN GuideExcellent patient teaching resources!
MedlinePlus: ArrhythmiaJan 5, '07 by VickyRN GuideThe Heart Information Center from Texas Heart Institute
Chock full of EXCELLENT patient teaching materials:
Through this community outreach program, staff members of Texas Heart Institute at St. Luke's Episcopal Hospital provide educational information related to the prevention, diagnosis, and treatment of cardiovascular disease.Jan 7, '07 by VickyRN Guide3D MEDICAL ANIMATIONS
The world�s largest library of 3D medical animations developed and copyrighted by Blausen Medical Communications. The Human Atlas features rotating model, labeled slides, and printable text in addition to animated videos.
Simply click on drop-down box to the far right (under Human Atlas)
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Used Mclaren cars for sale in Glossop
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Mclaren 650S SPIDER LHD 3.8 2dr
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Gift Premium Subscription To JehovahsWitnessProtection
Join Date:02-21-2013
Last Activity:03-13-2013 2:35 PM
Likes Given: 1
1 Likes on 1 Posts
Posted in thread: How to Use the Forum - How to do things! on 03-13-2013 at 02:04 PM
Can someone tell me how to delete my own account?That is a very good, and simple, question.
Funny, nobody had an answer. I would like to know as well, but my searches have come up empty
on the topic. ...
Posted in thread: Yeastcalc.com (Now two stir plate options?) on 03-12-2013 at 08:13 PM
Posted in thread: New happy birthday to me kettle! on 03-12-2013 at 03:27 PM
Nice! You going to start drilling holes in it for spigot, therm, etc.?B-day on St Patricks--2
more reasons to drink! Cheers! :drunk:
Posted in thread: Kettle size to burner ratio? on 03-10-2013 at 07:14 PM
Im curious about this burner made by sportsman. Anyone have this? not familiar with that unit,
but with the dimensions being 17.5" x 9.5" it appears you could run both burners with your 16"
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Posted in thread: The beer that got you into beer on 03-10-2013 at 06:09 PM
No single beer got me into brewing, as I enjoy many styles. I have a few friends who brew and
their influence and encouragement were key to getting me to take the plunge.Maybe better to say
which beer...
Posted in thread: What do you rock while you brew? on 03-09-2013 at 04:51 PM
Playing Dropkick Murphys today.
Posted in thread: Kettle size to burner ratio? on 03-09-2013 at 03:09 PM
[quote=juggabrew;4988361]Just bought a winware 10 gal brew kettle from amazon, the diameter Is
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...What about contaminants? Do i need a purifier? I will, of course sanitize before use and all
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Posted in thread: Hi from frozen Minnesota on 03-08-2013 at 02:36 PM
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Posted in thread: Hi from frozen Minnesota on 03-07-2013 at 09:59 PM
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Shares of Zynga, Inc. (NASDAQ:ZNGA) rose sharply late on Monday after the company confirmed it has named Don Mattrick as its new CEO, building on the press speculation circulating during the day. Founder Mark Pincus remains the chairman of the board and chief product officer.
Investors see Mattrick as a gaming industry veteran, having spent some 6 years at Microsoft. His last three years were in a role of president of the Interactive Entertainment Business, where he expanded Microsoft's (NASDAQ:MSFT) Xbox 360 global installed base by 700% to more than 75M consoles. In addition, Mattrick had an extended tenure as an executive at Electronic Arts where he helped develop a blockbuster franchise - "The Sims".
Why investors think it matters
The Zynga management team has been decimated with several high profile departures in the past few months. CIO Debra Chrapaty resigned in late March to lead cloud storage company Nirvanix. Head of the Zynga China unit, Andy Tian, stepped down late last month after three years of employment. The revolving door extends further to the second half of last year, when the COO, Chief Creative Officer, and several general managers in charge of mobile and divisions departed this free-falling online game maker.
Zynga's preferential human resources image has also been tarnished by a shareholder lawsuit alleging upper management was allowed to sell its shares, as lower level workers remained frozen in a post-IPO lockup period. A high-profile hiring could suggest there is some faith in the company's prospects among industry insiders, and a change of culture that could stave off Zynga's "Game Over" moment.
Is this really a "game-changer"?
We think, at best, it's too early to tell, and most likely not even close. For starters, it seems extremely suspicious that a division president with tech goliath tenure would jump aboard what appears to be a sinking ship. Last month, Zynga announced an 18% workforce reduction and the closure of several offices. It has been woefully behind the surge in mobile gaming and has watched the likes of Candy Crush by the privately held King crunch its domain.
By its own admission, Zynga is still relying on the Farmville franchise, while other games are under-performing as its user base shrinks - Q1 daily active users fell 20% on the quarter to 52M. Its bet on legalized gambling is most likely a long way from paying off, and even then an executive with a background in traditional gaming would hardly serve that purpose.
One may surmise that Mattrick is a "Trojan horse", potentially setting up a Microsoft bid for Zynga down the line, just as it attempts to make inroads in the smartphone space with the Windows Phone 8 OS. More likely however is that the opinionated Mattrick has dug his own grave when he told the gaming world that internet connectivity is an absolute requirement for the upcoming Xbox One upgrade, an embarrassing moment on which Microsoft had to backtrack. (Here's that infamous awkward interview with the new Zynga chief at the Electronic Entertainment Expo last month - starting around the 2:00 minute mark.)
We are neither long or short, but certainly skeptical and will surely tune in when Zynga posts its second quarter earnings in three weeks time. Until then, we wish to remind the reader that even the great Yahoo! Inc. (NASDAQ:YHOO) savior Marissa Mayer - incidentally appointed around the same time last year - had to prove her mettle and deliver results before Yahoo! shares started to climb later that fall.
For an interactive version of this chart, click on the image below. Price data sourced from Zacks Investment Research.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.
Business relationship disclosure: Kapitall is a team of analysts. This article was written by Gary Deduke, one of our writers. We did not receive compensation for this article (other than from Seeking Alpha), and we have no business relationship with any company whose stock is mentioned in this article.


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Ripoff Report | Complaints Reviews Scams Lawsuits Frauds Reported
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iHerb Customer Reviews
Savings of: $1.95 (10% off)
Note: Korean Customs will quarantine and inspect this item before final shipment to the customer. Please be advised that ordering this item could cause delivery delays
CapraMilk, Instant Powdered, 16 oz.
Posted by Reviewer1910203 on Oct 03, 2009
The powdered goat's milk has a slight goat taste, however, we don't mind and enjoy drinking it, especially when it's chilled. It's also very economical for our budget as I can make six quarts from the l6 oz. quantity. Thank you.
Posted by CIPRIAN on Feb 25, 2014
It is ok, but somewhat (almost) flavourless.
Love this!
Posted by Reviewer1099199 on Dec 18, 2013
Love to use this in my morning decaf tea or coffee. It is creamy and does not smell or taste goaty.
love the powdered goats milk!
Posted by Reviewer2524397 on Jan 11, 2012
this is by far the best powdered goats milk. It's smooth and creamy, almost buttery. We use it in smoothies and it adds a nice flavor and additional protein to the protein powder we use. It's great for those that cannot have soy or cows milk.
Pure and delicious
Posted by Reviewer1073358 on Mar 17, 2010
It is very creamy and pure.. I am very grateful that this has no nasty stuff. My child, 19 months old is consuming this daily.
Posted by Reviewer1354882 on Jan 05, 2011
This is the best tasting goat milk I have ever tasted. Mixes well. I will keep using it.
Posted by Reviewer2495812 on Jan 19, 2008
I make homemade yogurt and in order to get it thick I add 1/2 cup of this. I also made milk with this and it wasn't bad. I don't think I added enough though. The directions say add 2 tablespoons to 8 ounces of water. I think 3 is better but if you only add 2 make sure its a nice heaping tablespoon.
causes diahrrea?
Posted by kei-rylie on Feb 19, 2014
i bought this for my mom who's on tube feeding. i thought she would get the nutrients she needs but strangely she landed up having diahrrea. thought goat's milk's supposed to be the best kind.
just like goat milk
Posted by Reviewer1682718 on Apr 04, 2009
rather than vanilla or whatever tasting...
Posted by Reviewer1375850 on Feb 10, 2008
It is instant powdered goat's milk


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I don't want to be a burden to other people, I don't want to be the reason someone else sad because of me, I don't want to be the reason people get angry because of me, and I also don't want to be the reason the two men quarreled because of me. I also wouldn't be selfish, I wouldn't choose the two option. Although I know which one I love. I better sacrifice my feelings , than you should be hurt by my choice.
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Northern Michigan will not renew contract of head men's basketball coach Doug Lewis
MARQUETTE – Northern Michigan University will not renew the contract of head men's basketball coach Doug Lewis after three losing seasons in Marquette.
The Wildcats went backwards in 2012-13, finishing 5-21 overall and 4-18 in the GLIAC. Lewis finished 9-17 overall and 5-14 in the GLIAC last season after going 9-17 overall, 4-14 in the GLIAC in his first season at Northern.
"I wouldn't have changed anything because I thought we were going in the right direction," Lewis said Wednesday after addressing his team inside the PEIF. "It takes 4-5 years to change a program around. First thing you have to do is change the culture. Second thing you have to do is bring in talent. I thought we did both. We had a lot of injuries this year. We didn't win games."
Lewis came to Northern after seven seasons at Central State University, where he went 125-61 at the NCAA Division II independent institution.
Lewis said the only difference between Northern and Central State is time. From scholarships to facilities, NMU had everything he needed to succeed, Lewis said.
"Scholarships, they have the max and they have the facilities, a beautiful practice facility," Lewis said. "It's like Division I where you play in an arena. Even though we don't practice in (the Berry Events Center), a lot of Division I (schools) do the same thing that we do. There are no excuses.
"That's what got us talent in this program, the facilities."
NMU athletic director Forrest Karr said the decision not to bring Lewis back came after talking with alumni, former players, corporate sponsors, administrators and other co-workers within the department and with community members.
A national search will begin immediately, Karr said.
"Ultimately I just made a decision that I think the program has a better chance of being successful going forward if we make a change," Karr said.
"As a department, we're responsible to live up to the expectations of a lot of people that have been here in the past and been successful. I just feel like in this program, we're not meeting those expectations."
For more comments from Lewis and Karr, plus how the athletic department plans to conduct its search, stay logged on to www.miningjournal.net and follow Sports Editor Matt Wellens on Twitter at twitter.com/mattwellens


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Suzan Farmer
Born Jun 16, 1942
Suzan Farmer is an English actress, mainly on television. She first appeared in an episode of the Patrick McGoohan series Danger Man entitled No Marks for Servility and went on to feature in many other ITC series in the 1960s and 70s including UFO, The… Read More
Learn about the memorable moments in the evolution of Suzan Farmer.
1942 Birth Born on June 16, 1942.
1964 22 Years Old She played Sally Carstairs in the BBC's 1964 adaptation of Edmund Crispin's detective novel The Moving Toyshop. … Read More
1965 23 Years Old She was married to actor Ian McShane from 1965 to 1968.
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Suzan_Farmer.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


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Binge-watching has become an integral part of modern TV viewing, and Netflix CEO Reed Hastings is taking every opportunity to remind viewers that it's not offered on Time Warner's HBO.
AT&T, Comcast, Verizon, T-Mobile and Comcast are among the potential pool of qualified buyers that collectively satisfied the FCC's rules for the auction to be completed.
The media sector gains attention as there are more players for entertainment content.
AT&T CEO Randall Stephenson brushed off comments that it might have to consider selling CNN to get President-elect Donald Trump's approval for his company's $85.4 billion acquisition of Time Warner.


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No announcement yet.
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I worry about open source driver support for vega at release time but maybe they have it internally but i still think it will need DC (DAL)....
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Nille_kungen replied to Valve Developer Posts New AMD GPU Debugging Tool, Part Of Improving Linux DriverDidn't you also use to have an T60 with an ATI dgpu in the X1400 series?...
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I can't see the polaris 12 patches if that's what you mean....
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in Linux GamingWatch the video in this article http://www.phoronix.com/scan.php?pag...on-Driver-Mods
It answers your question....
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Samuel Pitoiset did send a small patch 3 days ago but he used an gmail adress but as i understand it he know works for valve with radeonsi.
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Nille_kungen replied to Former Nouveau GSoC Developer Now Working For Valve On Open-Source AMD Driverin Linux GamingCongrats Samuel for the new job and it's great to see more efforts for radeonSI and your expertise.
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The Music City Minute
Our first winner of tickets to Jake Owen at ISU Hulman Center
Aug. 18, 2014
This week we're giving away tickets to the 'Days of Gold' tour at ISU Hulman Center Friday night October 10th! Tickets go on sale this Friday, but you can win them BEFORE they even go on sale! Anytime you hear 'Days of Gold' play this week on HI-99, be caller 9 at 812-478-1499 and win tickets to see Jake Owen with the Eli Young Band & The Cadillac Three!
Here's our first winner, Cheryl Wrightman of Terre Haute from this morning. Listen all week and you could be next!


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News By Tag
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Judy Terwilliger of Knowmor, Inc. Featured on Ask.com
Judy Terwilliger of Knowmor released a new article "It's Not My Fault"... A Mommy - Infant Lament © which was featured on Ask.com May 9th.
The resurgence of infant, maternal - child and family bonding through the miracle of breastfeeding has been a refreshingly welcome focus in our ultra-modernized society. The joy of being born to loving parents is no where played out more than in the art of breastfeeding. The nurture with the neuro-developmental benefits that it affords our society's offspring is nothing short of amazing.
Often though, our developing medical advancements, with managed care, have provided not only help to save lives but have presented challenges in the child bearing process. It would seem that more and more babies, new moms and families can be found to experience unknown obstacles, even hidden barriers on their breast feeding path.
Many are the moms whose bonding dream feels shattered by the real life struggle to see this art as positive, with her endeavor seemingly unsuccessful. Meanwhile, her baby struggles to connect at her breast, find comfort in her offer of warmth and care and bond with just less than a seeming war. Both are engaged in an uncertain process that is supposed to be so natural. Dad watches helplessly.
The pediatrician cannot explain this disconnect. At first glance all seems "normal" with baby and a referral to a certified lactation consultant ensues. However, try though they may with various position changes and/or the reduction of any tongue-ties discovered, the process is still filled with pain, rooting, latching failure or an ineffective transfer of milk, all while mom's supply wanes. Failure seems imminent.
The frustration, the tears of helplessness and the chaotic life that follows, all in the pursuit of a natural wonderful experience, leads this mom to wonder what she is doing wrong. She blames her self for what she cannot understand is happening, especially when it seems she is doing her best.
Something that is supposed to be so right has gone so wrong. If baby could talk, his/her cry would mirror mom's lament, "It's not my fault. I'm trying so hard!"
The truth is, there may be a real hidden barrier no one sees that is preventing both from connecting as nature intended. We are totally integrated beings, but a critical structural component may be missed, muscle tension resulting from the "normal" high intensity process we call birth. Few health care providers know of, consider and/or seek to address this key impediment to a natural experience.
Though the actual delivery process is managed in many ways for the best possible out come, it is still highly likely that despite these best of efforts, baby's response to the birth process is traumatic. This reaction to the birth process is absorbed by his/her musculature producing a form of tension at the neck, which has a cascading effect on baby's entire musculature. Resulting high muscle tone (from the congestion present) then creates a structural hindrance to normal muscle movement and ultimately can produce an unseen structural barrier to neuro muscular function.
This largely unseen, often un-factored barrier to functional mobility is the real culprit in the breastfeeding dilemma. The ultimate body response is to withdraw from the discomfort produced by the use of the muscles that support or are associated with an over-tight head, jaw, neck, back, and/or shoulders.
It's really no one's fault! It is simply a hidden barrier that baby has developed from his/her exposure to the developmental and birth process.
When this structural problem is properlyacknowledged, evaluated and therapeutically relieved - normal functional movement in baby is restored. The joy of breastfeeding is saved. Tears of anguish become tears of joy, as this connection miracle is reborn with family peace and sanity restored.
For more information on this insidious barrier to the true joy of the breastfeeding connection visit http://www.strugglingtofeedmybaby.com and http://www.knowmor.org
To see the article as was featured on ask.com visit http://markets.ask.com/
Judy Terwilliger RN, CMT, CBTPediatric™
Her specialties include practice in the hospital, clinic and office settings, Pediatrics, Medical/Surgical, CCU, Internal Medicine, Ear/Nose/Throat, Urology, Orthopedics, Gastroenterology, In Home Rehab and much much more.
She is an active member of the National Society of Pediatric Nurses and the American College of Sports Medicine and a featured speaker at the Northern California, Placer County Breastfeeding Coalition.
Knowmor, Inc.
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15 posts tagged with Mathematics by Blazecock Pileon.
Displaying 1 through 15 of 15.
ASCII fluid simulator
Card tricks...
...to leave a smile on your face, by Helder Guimarães: Individual vs Crowd | Chaos | Freedom | Trick [more inside]
The sound of graph paper
GaMuSo is an application of BioGraph-based data mining to music, which helps you get recommendations for other musicians. Based on 140K user-defined tags from last.fm that are collected for over 400K artists, results are sorted by the "nearest" or most probable matches for your artist of interest (algorithm described here). [more inside]
Evolved design
Unleashing Genetic Algorithms on the iOS 7 Icon - In the pursuit of something just a bit tighter than Marc Edwards' superellipse approximation, Mike Swanson applies genetic algorithms to the task of making a better button-making script.
The Art of π, φ and e
Putting a style in your crimp
Le Crimp (mostly en français) is a French collective that explores organic and abstract geometric [ I | II | III ] (PDFs) approaches to the art of origami. Read the white papers, browse the gallery or watch videos of artworks being made or being used in still-motion animations
Pixel Pickle
Editors of the pop-culture magazine Wired provided the title "iPhone 4's 'Retina' Display Claims Are False Marketing" to a highly critical article about the new iPhone's high-resolution "Retina" display, so-called as the human eye cannot resolve individual pixels when viewing it. A technician who worked on the Hubble telescope disagreed with the Wired editors' choice of rhetoric in very strong technical terms and issued less stringent disagreement with Raymond Soneira, the writer of the piece. Neuroscientist and photographer Bryan Jones published his own highly readable technical analysis of the display's pixel arrangement, that helped him decide whether Apple's claims were truthful or not.
"Enhance 15 to 23. Give me a hard copy right there."
Rock the streets
Whether you want to learn to lace shoes, tie shoelaces, stop shoelaces from coming undone, calculate shoelace lengths or even repair aglets, Ian's Shoelace Site has the answer!
Would you like to play a game?
Fun and games with mathematics and mathematical puzzles (e.g. heart basket, Rubik's Cube, Rubik's Magic, hypercubes, and more) in both English and (with yet more content in) German.
Life is complex: it has both real and imaginary components
More than fifty selected articles from The Princeton Companion of Mathematics (username: Guest, password: PCM) — a thematically-organized compendium of mathematics and mathematicians from Fields Medal-winner Tim Gowers. [via, previously]
In Soviet Russia, sponge soaks you
Dr. Jeannine Mosely finishes building a level-3 Menger sponge from business cards. You can also build your own, though Dr. Mosely warns, "[a] level 4 sponge would require almost a million cards and weigh over a ton. I do not believe it could support its own weight — so a level 3 is the biggest sponge we can hope to build." (related)
Kinseyian mathematics, of a kind
The "Darwinian paradox" of homosexuality presents the conundrum of how a potential genetic basis for homosexual behavior could provide a survival benefit to offpsring and extend through generations, when sexual reproduction would seem to place strong selection pressure against such a "gene". Recently developed mathematical models (PDF) from researchers Sergey Gavrilets and William Rice not only show how a "gay gene" might proliferate within a population, but also provides testable hypotheses, including predictions of "widespread bisexuality" (subscription req'd).
Good times, good times!
Autodidactic goodies on a budget: Free computer books and online lectures, seminars and instructional materials from a variety of renowned institutions.
Turing: The Final Years
Among his collected works, in the few, short years before mathematician Alan Turing was driven to suicide, he published "The Chemical Basis of Morphogenesis", theorizing how a standing wave-like distribution of "cannibal" and "missionary" chemicals might explain how plants and animals develop their shape and pigmentation. Blogger Jonathan Swinton focuses on this more obscure aspect of Turing's research, and reviews some of his posthumous and unpublished efforts — including one of the earliest known examples of digital computation applied to the field of biology.
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Selle Italia SMOOTAPE Gran Fondo
It does not take much to transmit your own identity, just one colour is enough. After the success of the black and white versions, Selle Italia now offers Smootape in wide range of brilliant shades and performing textures to optimise grip and fully express the personality of whoever is in the saddle.
All the Smootape tapes offer a perfect grip and they are only ones that eliminate the imperfactions from overlapping, ensuring that the taping is smooth thanks to the exclusive international patent deposited by Selle Italia (PATENT PENDING ITVI2010A000210).
To help the consumer choose, the tapes have been subdivided into four categories: Smootape Corsa, Smootape Gran Fondo, Smootape Controllo and Smootape Classica.
- Weight: 50g
- Dimensions: 35×1800mm
- Thickness: 2.5mm
All orders dispatched by Royal Mail.
Items with a value of greater than £50 are sent Royal Mail signed for.
Bulky items (groupsets, wheels & turbo trainers) are sent by courier
- Unless damaged or defective, we accept the return of items only if they are unopened (except in cases where the item has to be tried for fit) and in their original condition. In the case of clothing which have to be tried for fit, any returns must be in their original packaging and with any labels still attached.We reserve the right to refuse a returned item if labels have been detached .
- Returns form must be included in your parcel failure to do so could result in delays .
- Must not exceed 2 kg
- Please ensure that you retain your proof of postage off Royal mail as this may be required to process refunds/exchanges and failure to provide this may result in your refund/exchange not being processed .
- We are unable to refund postage that you have paid for yourself unless it has been pre-authorized by Vanilla bikes.


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Lunching with Lakers voice Spero Dedes
Some people hang out by the beach all summer.
Only one goes to broadcast NFL games for CBS while on break.
Lakers radio play-by-play broadcaster Spero Dedes' star is rising, as seen by him calling the final of his three pre-assigned NFL telecasts Sunday with the Raiders-Cardinals game. (Despite the Raiders' popularity in Southern California, those of us in Southern California still won't hear Dedes without DirecTV's Sunday Ticket because the Chargers-Seahawks game has been assigned geographically.)
Dedes might do a couple more NFL games this season if some scheduling works out, and then there'll be the NCAA Tournament again, but otherwise it's soon back to Lakers business for Dedes. He is entering his sixth season calling Lakers games.
He took time out from his NFL prep work to have lunch Wednesday at Petros in Manhattan Beach – although Dedes did offer some strong words regarding the Raiders' decision to bench quarterback Jason Campbell: "Very premature. After six quarters to change their mind on this quarterback they've said for so long is their guy, it just reinforces in people's minds what they think about the lack of organization."
To discover some choice nuggets from my lunch conversation with Dedes, including the quietest he heard the Lakers' team plane all last season and what he thinks of the Lakers' offseason roster moves, click on the photo to the left.
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i left the s off. that's ideas.
July 31, 2011 at 11:57 AM in feathers, light and dark, magic, points and protrusions, redefinition, symbols, the month of the magic feather, the real journal project- loose pages, working in a series | Permalink
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Taylor Hackford
Film Director
Born Dec 31, 1944
Taylor Edwin Hackford is an American film director, and the current president of the Directors Guild of America.
View newly released photos of Taylor Hackford.
News + Updates
Browse recent news and stories about Taylor Hackford.
Robert De Niro In The Comedian: De Niro's Busy WeekHuffington Post - Dec 05, 2016
Robert De Niro Thinks Helen Mirren Is A 'royal Milf'Huffington Post - Dec 01, 2015
Bryan Cranston's Pin: Trumbo PremieresHuffington Post - Nov 06, 2015
Maureen O'hara: The Roads To Recognition, Co Starring Lillian Gish And Robert AltmanHuffington Post - Oct 19, 2015
Learn about the memorable moments in the evolution of Taylor Hackford.
1944 Birth Born on December 31, 1944.
1968 23 Years Old Hackford was born in Santa Barbara, California, the son of Mary (née Taylor), a waitress, and Joseph Hackford. He graduated from the University of Southern California in 1968, where he was a pre-law major focusing on international relations and economics. … Read More
1997 52 Years Old … Hackford and Mirren wed in 1997 after 12 years together, although as a young woman Mirren had vowed never to marry. … Read More
2005 60 Years Old 1 More Event
In a 2005 interview, Hackford confirmed that he never watched his own films: "When I finish a film, I put it away and I never look at it again. … Read More
2009 64 Years Old On July 25, 2009, Hackford was elected President of the Directors Guild of America.
2011 66 Years Old He was re-elected to a second, two-year term as President on June 25, 2011, at the DGA's National Biennial Convention in Los Angeles.
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Taylor_Hackford.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


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