text:
Terms & Conditions
These terms and conditions ('the Terms') govern the users
('you' or 'your') use of the website www.Zavvi.com ('the Website') and your
relationship with TheHut.com Limited whose registered office is at Meridian
House, Gadbrook Park, Gadbrook Way, Rudheath, Northwich, Cheshire, UK, CW9 7RA
and or TheHut.com (Trading) Limited whose registered office is at 17 The
Esplanade, First Floor, St Helier, Jersey, JE2 3QA (as the case may depending
upon who fulfils your Specific order) ('we', 'our' or 'us'). Please read them
carefully as they affect your rights and liabilities under law. If you do not
agree to these Terms, please do not access nor use the Website. If you have any
queries regarding these Terms then please contact us.
By using the Website
you agree to be bound by these Terms.
We reserve the right to:
• Update these Terms from time to time and any changes will
be notified to you via a suitable announcement on the Website. It is your
responsibility to check for such changes. The changes will apply to the use of
the Website after we have given such announcement. If you do not wish to accept
the new Terms you should not continue to use the Website. If you continue to
use the Website after the date on which the change comes into effect, your use
of the Website indicates your agreement to be bound by the new Terms; and
• modify or withdraw, temporarily or permanently, this
Website and the material contained within (or any part) without notice to you
and you confirm that we shall not be liable to you for any modification to or
withdrawal of the Website or its contents.
You warrant that:
• The personal information which you are required to provide
when you register is true, accurate, current and complete in all respects; and
you are not impersonating any other person or entity The products purchased on
this site are for private and domestic use only and are not for re sale. You
will notify us immediately of any changes to the personal information by
our customer service representatives at:
• E-mail address: firstname.lastname@example.com
Privacy Policy
We will treat all your personal information as confidential
and will only use it in accordance with our Privacy Policy.
When you shop on this Website, we will ask you to input personal details in
for us to identify you, such as your name, e-mail address, billing address,
address, credit card or other payment information. We confirm that this
information will be held by us in accordance with the registration we have with
the Data Commissioner's office.
Protecting Your Security
To ensure that your credit, debit or charge card is not
being used without your consent, we will validate name, address and other
information supplied by you during the order process against appropriate third
party databases. We take the risk of internet fraud very seriously. With the
volume of fraudulent credit card transactions increasing, we make every effort
to ensure all orders are thoroughly checked using the information already
supplied. There is a possibility we may contact you to make additional security
checks and we ask for your co-operation to enable us to complete them. We will
not tolerate fraudulent transactions and such transactions will be reported to
the relevant authorities.
By accepting these terms and conditions you consent to such
checks being made. In performing these checks personal information provided by
you may be disclosed to a registered Credit Reference Agency which may keep a
record of that information. You can rest assured that this is done only to
confirm your identity, that a credit check is not performed and that your
credit rating will be unaffected. All information provided by you will be
treated securely and strictly in accordance with the Data Protection Act 1998.
The Website may only be used for lawful purposes and in a
lawful manner. You agree to comply with all applicable laws, statutes and
regulations regarding the Website and its use. You agree not to upload or
transmit through the Website:
• Any computer viruses or anything else designed to
interfere with, interrupt or disrupt the normal operating procedures of a
computer; and
• Any material which is defamatory, offensive
or of an obscene character
You agree to fully indemnify, defend and hold us, and our
officers, directors, employees and suppliers, harmless immediately on demand,
from and against all claims, losses, costs and expenses, including reasonable
legal fees, arising out of any breach of these Terms by you, or any other
arising out of your use of this Website or any other person accessing the
Website using your personal information.
Third Party Links
As a convenience to our customers, the Website may include
links to other websites or material which is beyond our control. For your
information, we are not responsible for such websites or material nor do we
review or endorse them. We will not be liable, whether directly or indirectly,
the privacy practices or content of such websites or for any damage, loss or
offence caused or alleged to be caused in connection with, the use of or
reliance on any such advertising, content, products, materials or services
available on such external websites or resources.
All orders are subject to acceptance and availability. If
the goods ordered are not available, you will be notified by e-mail (or by
other means if no e-mail address has been provided) and you will have the
option either to wait until the item is available from stock or to cancel your
Any orders placed by you will be treated as an offer to
purchase the goods or services from us and we have the right to reject such
offers at any time. You acknowledge that any automated acknowledgment of your
order which you may receive from us shall not amount to our acceptance of your
offer to purchase goods or services advertised on the Website. The conclusion
of a contract between you and us will take place when we (i) debit your credit,
debit card or PayPal account or (ii) dispatch the goods to you or commence the
services, whichever is the later.
We will take all reasonable care, in so far as it is in our
power to do so, to keep the details of your order and payment secure, but in
the absence of negligence on our part we cannot be liable for any loss you may
suffer if a third party procures unauthorised access to any data provided by
you when accessing or ordering from the Website.
The products sold on the Website are not for re-sale or
distribution. You are limited to a purchase of 5 items of any one product. We
reserve the right to cancel orders and/or suspend accounts where we believe
products are being ordered in breach of this provision.
You will assume the risk for the products once they have
been delivered to the delivery address which you specified when ordering the
We accept no liability where you provide an incorrect delivery address or where
you fail to collect the products from the delivery address which you specified.
Deposit Items certain high value items are not readily
available from stock and require a production order to be placed on the
supplier. Such items are identified on our Websites as Preorder items. In order
to secure supply of these items, prior to confirmation of your order we will
require you to pay a deposit of the total order value. When ordering such items
you agree that the expected delivery date can be variable. We will keep you
informed by email of expected delivery times which in certain circumstances may
be up to approximately twelve weeks.
Cancellation Rights
Where you have purchased the goods or services as a consumer (i.e. for private
use as opposed to business use), please note that you are entitled to cancel
any contract completed with us within 14 days from the day the item is
To exercise the right to cancel, you must inform us of your decision to cancel
this contract by a clear statement (e.g. by selecting the appropriate option in
your account or a letter sent by post). Alternatively, please contact us if you
wish to use our model cancellation form.
Please ensure that the items you are returning are unopened and in any original
packaging. Unwanted goods need to be in pristine condition with any retail
seals unbroken.
Our Returns Policy does not affect your statutory rights.
Price and Payment
All prices shown are inclusive of VAT (where applicable) and
are correct at the time they are entered on to the system. We reserve the
right, however, to change prices at any time without notice to you.
Orders with a delivery address outside the UK may be subject
to import duties and taxes (including VAT) which are levied once a delivery
reaches your destination country. Any such additional charges must be borne by
you. You should note that customs policies and practices vary widely from
country to country. We recommend that you contactyour local customs office for
Please note that when shipping goods from outside of the
United Kingdom, cross border shipments may be subject to opening and inspection
by customs authorities. In respect of all goods dispatched to you to an address
outside of the United Kingdom, you are deemed to be the importer of the goods
and must therefore comply with all the laws and regulations of the country into
which the goods are being delivered.
Payment can be made by any major credit or debit card or via
your PayPal account.
Payment will be debited and cleared from your account before
the dispatch of your good or provision of the service to you. If payment is to
be made via a credit card a value of £0.01 will be held against the card until
card issuer validates the payment.
In the unlikely event that the price shown on the checkout
page is wrong, and we discover this before accepting your order in accordance
with clause 9, we are not required to sell the goods to you at the price shown.
We always try and ensure that the prices of goods shown on our Website are
accurate, but occasionally genuine errors may occur. If we discover an error in
the price of the goods that you have ordered we will let you know as soon as
possible and give you the option of reconfirming your order at the correct
price or cancelling it. If you cancel your order and you have already paid for
the goods, then you will receive a full refund.
You confirm that the credit, debit card or PayPal account
that is being used is yours. All credit/debit cardholders are subject to
validation checks and authorisation by the card issuer. If the issuer of your
payment card refuses to or does not, for any reason, authorise payment to us we
will not be liable to you for any delay or non-delivery.
You may only use one discount code with each order. We
reserve the right to reject or cancel any orders where you add more than one
discount code to the basket.
We allow you to use discount codes strictly on the terms and
conditions upon which they were issued which, amongst other things, may include
terms relating to your eligibility to use them and a maximum order value.
Discount codes that are valid across the entire site exclude the following
products - Click Here for
the full list.
Please familiarise yourself with these terms and conditions
before you place an order as we reserve the right to reject or cancel any
which do not comply with these terms even if your credit or debit card has been
charged. If there is any inconsistency between the terms and conditions upon
which the discount codes were issued and these terms and conditions, the
discount code terms and conditions prevail. A copy of the discount code terms
and conditions can be obtained by mailing or telephoning our customer service
representatives at:
• e-mail address: email@example.com
Eligibility to Purchase
To be eligible to purchase goods on this Website and
lawfully enter into and form contracts on this Website under English law you
If an individual, be 18 years of age or over; and register
your real name, address, phone number, e-mail address any other details
By offering to purchase goods and services you represent to
us that you are 18 years of age or over and authorise us to transmit
information (included updated information) to obtain information from third
parties, including but not limited to, your debit or credit card numbers or
credit reports to authenticate your identity, to validate your credit card, to
obtain an initial credit card authorisation and to authorise individual
purchase transactions.
Intellectual Property
The content of the Website is protected by copyright, trademarks,
database and other intellectual property rights and you acknowledge that the
material and content supplied as part of the Website shall remain with us or
our licensors you may retrieve and display the content of the Website on a
computer screen, store such content in electronic form on disk (but not any
server or other storage device connected to a network) or print one copy of
such content for your own personal, non-commercial use, provided you keep
intact all and any copyright and proprietary notices. You may not otherwise
reproduce, modify copy or distribute or use for commercial purposes any of the
materials or content on the Website.
Limitation of Liability
Notwithstanding any other provision in the Terms, nothing in
these Terms: affect or limit your rights as a consumer under English law; or
will exclude or limit our liability for death or personal injury resulting from
our negligence. The Website is provided on an 'as is' and 'as available' basis
any representation or endorsement made and we make no warranties, whether
express or implied, in relation to it and its use. You acknowledge that we
cannot guarantee and cannot be responsible for the security or privacy of the
Website and any information provided by you. You must bear the risk associated
with the use of the Internet.
Whilst we will try to ensure that material included on the
Website is correct, reputable and of high quality, we cannot accept
responsibility if this is not the case. We will not be responsible for any
errors or omissions or for the results obtained from the use of such
information or for any technical problems you may experience with the Website.
If we are informed of any inaccuracies in the material on the Website we will
attempt to correct this as soon as we reasonably can.
In particular, we disclaim all liabilities in connection
with the following:
Incompatibility of the Website with any of your equipment,
software or telecommunications links; Technical problems including errors or
interruptions of the Website; unsuitability, unreliability or inaccuracy of the
Website; and failure of the Website to meet your requirements. To the full
extent allowed by applicable law, you agree that we will not be liable to you
or any third party for any consequential or incidental damages (both of which
terms includes, without Limitation, pure economic loss, loss of profits, loss
of business, loss of anticipated savings, wasted expenditure, loss of privacy
and loss of data) or any other indirect, special or punitive damages whatsoever
that arise out of or are related to the Website.
If any part of the Terms shall be deemed unlawful, void or
for any reason unenforceable, then that provision shall be deemed severable
from these Terms and shall not affect the validity and enforceability of any
remaining provisions of the Terms.
Waiver No waiver
By us shall be construed as a waiver of any proceeding or
succeeding breach of any provision.
Entire Agreement
These Terms form the entire basis of any agreement reached
between you and us.
Law and Jurisdiction
These Terms shall be governed by and construed in accordance
with the laws of England and Wales and any disputes will be decided only by the
English courts.
All Competitions
We reserve the right to amend these Terms without notice
from time to time. These rules will be deemed incorporated into each competition
except to the extent that any specific instruction in a competition provides
otherwise. By entering the competition entrants will be deemed to have read and
understood these Terms and be bound by them. All of our decisions will be final
and binding and no correspondence will be entered into. Any person who is an
employee or an immediate family member of an employee of any The Hut Group
company or any other person who is directly connected with the organisation of
any particular competition is ineligible to participate.
Competitions are only open to residents of the UK (excluding
Northern Ireland).
All entrants are to be aged 18 or over unless any other age
restriction is specified or implied. Entrants should, if under than 18, obtain
permission in advance from their parent or guardian.
All entries must be received by the closing date specified
in the competition.
Answers will be entered upon submission. No responsibility
will be taken for any answers that are misdirected, lost for technical or other
reasons or received after the closing date.
We reserve the absolute right to disqualify without notice
any entries to any competition which we consider have used improper technical
means to enter and/or we believe is fraudulent. Entrants are liable for their
costs to access computer networks. We will not be liable for or accept any
responsibility for: (i) any failure by the winner or any entrant to comply with
these terms and conditions; (ii) any disruption, delay or misdirection of
entries; or (iii) any server, system or network failures, malfunctioning or
We shall be the promoter of all competitions subject to these terms and
conditions unless stated otherwise. Prizes if for any reason an advertised
prize is unavailable we reserve the right at our absolute discretion to
substitute a similar prize of equivalent or greater value. Only one prize will
be awarded per household. There will be no cash or other alternative to the
offered and prizes are not transferable. Notification the winner's name will be
selected in a random draw, after the closing date, from all correct answers
received. The winner of a prize will be notified within 28 days after the
winner has been ascertained.
Please allow 28 days for delivery of all prizes.
If the winner of the a competition is unable to take up a prize for any
reason or if the winner cannot be notified after reasonable efforts having been
made then we may dispose of the prize as we think fit without any liability to
the winner for having done so.
For each competition, only one prize will be awarded per entrant / email
address. Names of winners will be available on request. The names of the
winners may be published on our Website and/or on our Facebook, Twitter or any
other social media platform.
Claiming Prizes
Prizes Involving Travel: (a) Travel arrangements are the responsibility of
prize winners unless otherwise stated; (b) we reserve the right to require
written permission from the parent or guardian of any winner who is under the
age of 16 and to require such a winner to choose as a companion someone 18 or
Prizes/tickets may be restricted to certain times
of the year
and unless otherwise
stated all prizes must be taken within six months of the date of the
competition draw.
Where prizes are to be provided by a third party then the winner will be
required to complete all appropriate or applicable booking or other formalities
direct with such providers. We will have no responsibility for the
acts/defaults of any other persons or companies.
If you submit a review, you grant us a non-exclusive, royalty-free,
perpetual, irrevocable, and fully sub-licensable right to use, reproduce,
adapt, publish, translate, create derivative works from, distribute, and
display such content throughout the world in any media.
You grant The Hut.com Limited and its sub-licensees the right to use the
name that you submit in connection with such content, if they choose. You agree
to waive your right to be identified as the author of such content and your
to object to derogatory treatment of such content.
You agree to perform all further acts necessary to perfect any of the above
rights granted by you to The Hut.com Limited, including the execution of deeds
and documents, at the request of The Hut.com Limited.
You represent and warrant that you own or otherwise control all of the
rights to the content that you post; that, as at
the date that
the content or
material is submitted to The Hut.com Limited:
1. The content and material is accurate;
2. Use of the content and material you supply does
not breach
any applicable
The Hut.com Limited guidelines and will not cause injury to any person or
entity (including that the content or material is not defamatory). You agree to
indemnify TheHut.com Limited for all claims brought by a third party against
The Hut.com Limited arising out of or in connection with a breach of any of
these warranties.
Winners of the review competition will be notified
by email.
Failure to
respond to our notification email
within 20 days will result in the prize being forfeited.
Gift Vouchers
The ZAVVI Gift Voucher can be used to buy any item sold by www.Zavvi.com.
Our normal terms and conditions, together with the terms and conditions below,
apply to the purchase of your gift voucher. You can email it to family and
friends, or print it out to give to them personally. It is the perfect way to
give a gift when you don't know what to buy!
is a ZAVVI Gift Voucher?
Gift Voucher is available in £10, £25, £50, £75 and £100 denominations and
you to give a gift when you don't know what to buy. Gift Vouchers are issued
via email using an electronic voucher code which can then be redeemed in the
Checkout to buy any product on www.Zavvi.com.
How do I order a Gift Voucher?
- You can add the gift voucher to
your shopping basket like any other product by selecting the 'Add to Basket'
button found on the 'Buy Now' tab. Then continue to checkout to complete your
order. If you want to purchase more than one Gift Voucher you can increase the
item quantity on the basket page or go back to the relevant Gift Voucher
product page and add more items to your basket. You can also buy other products
at the same time as placing your order for Gift Voucher(s). Gift Vouchers are
valued and issued in GBP Pounds.
Discount codes cannot be used when purchasing a Gift Voucher.
How will I receive a Gift Voucher?
– Once your order has been processed
and we have taken payment, you will be emailed the electronic Gift Voucher code
to the email address where your order confirmation email is also sent. You will
not receive anything in the post for Gift Vouchers that you order.
How do I give the Gift Voucher to the recipient?
- Once you have received the
electronic Gift Voucher code you can then forward on this email to the gift
recipient, or you can print out the voucher and give it to them. Gift Vouchers
are valid for 12
Month's from the date of purchase. I am the
recipient of a Gift
How do I redeem it? - Gift Vouchers can be used to purchase any product on
www.Zavvi.com. Select the item(s) you wish to order and add them to your
basket. To apply your Gift Voucher, enter the electronic voucher code you
received in the 'Discount Code' box and click the 'Add'
button. This will then apply the voucher to your order. Then proceed to the
as normal.
What are the restrictions?
- You can only use one voucher per
order and no change will be issued if the full value of the voucher is not used
in the order. Gift Vouchers are valid for 12 months from the date of purchase
so make sure you remember to redeem your Gift Voucher in time. Gift Vouchers
are valued and issued in GBP Pounds. You cannot use your Gift Voucher in
conjunction with any other discount code.
I have paid for an order using a Gift Voucher. What happens if I want to
return my order?
- For orders which are refunded, the
refund will be issued via the same payment method as used to pay for the order.
Therefore if you have paid, or part-paid, for an order using a ZAVVI Gift
Voucher any refund will be issued in Gift Vouchers to the same value.
I have lost a Gift Voucher. What do I do?
- If you are the recipient of a ZAVVI
Gift Voucher please ask the purchaser if they still have details of your
Voucher Code. We can only reissue gift vouchers which have
not been redeemed. For the avoidance of doubt, the original gift voucher will
be void if we issue a replacement. The original expiry date will still apply.
Risk and Loss
- The risk of loss and title for a Gift Voucher shall pass to the purchaser
upon our electronic transmission of the Gift Voucher to the purchaser or
designated recipient, whichever is applicable. We are not responsible if any
Gift Voucher is lost, stolen, destroyed or used without your permission.
- We will have the right to close customer accounts and take payment from
forms of payment if a fraudulently obtained Gift Voucher is redeemed and/or
used to make purchases on www.Zavvi.co.uk.
Can I return my Gift Voucher?
- Gift Vouchers cannot be returned or
refunded, except in accordance with your statutory
rights. The
value of the gift
voucher cannot be converted back to cash.
Multibuy Offers
This offer applies only to qualifying items listed in the Multibuy area of
this Website. Where any goods are returned (except for an exchange where
products are faulty/defective), we are entitled to either require the return of
all goods delivered as part of that Multi-buy offer at your cost or charge you
for the goods retained by you at the full price quoted on this site.
Gift With Products Promotions
Where we are offering a free gift with a product, we shall only provide one
gift per transaction (irrespective of how many products are purchased). The
free gift is subject to availability and we reserve the right to change the
gift for a gift of equivalent value.
In order for us to facilitate theprovision of a free gift, it may be
necessary for us to include the free gift
on our site at a nominal value. For the avoidance of doubt, you are not
entitled to 'purchase' the free gift without purchasing the product it is
provided free with and any attempt to 'purchase' the free gift will be
cancelled (notwithstanding any automated communication you may receive
acknowledging your order). In the unlikely event that the free gift is
despatched to you, you shall be obliged to return the free gift upon written
Waste Electrical or Electronic Equipment
We are pleased to offer all of our customers buying
new electrical items the chance to recycle qualifying old electrical items for
free. For full details please click
ZBox Subscription Terms and Conditions
By subscribing to our "ZBox" service, you acknowledge that you agree to
our Terms and Conditions.
Stock is subject to availability, you
may receive the first
"ZBox" in the same month that you place your order. For example, if you
subscribe in January, your subscription may begin with the January
"ZBox". If the monthly "ZBox" is not available in the month you place your
order, your subscription will start in the subsequent month.
The date on which we ship the ZBox will
vary from month to
month. Please note that on occasion there may be shipping delays and/or
product back-orders due to unforeseen issues involving the brand
fulfillment process. Any estimated delivery dates are estimations only and
you will not be eligible for a refund due to any unforeseen delays. As
soon as your "ZBox" is on its way, you will receive a confirmation email
containing a tracking number that allows you to monitor its shipment. You
will not be eligible for a refund due to any unforeseen delays.
If you change address during the term of your
subscription, you
can do this via your account and it will take effect the following month.
If you have not changed your address before the following month's box has
been created then we shall not be liable to you in the event that you fail
to receive your "ZBox" and no refund shall be provided.
Each subscription is classed as a single
sales contract for
regular delivery of goods, so you are only entitled to receive a refund if
you cancel your subscription with us within 14 days from the day on which
you acquire physical possession of your first "ZBox".
You are entitled to cancel your subscription
at any time,
however unless you cancel your subscription with us within 14 days from
the day on which you acquire physical possession of your first "ZBox", you
will not be entitled to a refund.
The above cancellation policy does not affect your statutory rights.
Please see clause 10 above for further information about your right to
We reserve the right to cancel your
subscription at any
time as a
result of any breach of these Terms. We also reserve the right at our
absolute discretion to cancel and/or change the "ZBox" subscription model.
• You must
be 18 years or over at the time of entry to enter this prize draw.
• You must
be resident in the United Kingdom (excluding Northern Ireland) to enter this
prize draw.
• The prize
draw is not open to anyone associated with the promotion, including employees
and officers of the Promoter and/or any member of The Hut Group or their
families and anyone professionally connected with the prize draw including (but
not limited to) employees of the marketing agencies used by the Promoter or
• This prize
draw closes at 23:59 on 28th July 2016. Entries sent after this time
will not be entered into the prize draw but may still be charged.
• To be eligible to enter the prize draw, you must
text ZAV to 88440 before the prize draw closes. We will not charge you
for entry but standard network charges will apply.
• There will be one winner and two runners
up. The winner and each runner up will be randomly drawn from all
eligible entries following the close of the prize draw under the supervision of
an independent observer and will be notified via the phone number held by the
Promoter within 30 days of the closing date.
• The
winner's and each runner up's name will be published on the Zavvi website
• The winner
will receive a £100 Steelbook
voucher to spend on the Website and each runner up will receive a £50 & £25
voucher respectively to spend on steelbooks from Website.
• By
entering the prize draw you agree to any PR or marketing any member of The Hut
Group wishes to undertake to promote its websites or products (using the phone
number that you provided when you entered the prize draw and including
marketing by way of text).
• The prize
cannot be exchanged, refunded or transferred. No cash alternative is
• The
Promoter reserves the right to disqualify without notice any entries that it
believes are fraudulent.
• The
Promoter's decision is final and no correspondence will be entered into.
• The
Promoter reserves the right to change these terms and conditions at any time
(and any such change shall be notified to you by text).
• Entry into
the prize draw will be taken as acceptance of these terms and conditions.
The prize draw and these terms and conditions are governed by English law and
subject to the exclusive jurisdiction of the English Courts.
The Hut.com Limited a company registered in England and Wales (company number
05016010) whose registered office is at Meridian House, Gadbrook Park,
Rudheath, Cheshire, CW9 7RA.


text: On Thu, Jun 4, 2009 at 5:32 PM, Bennett, Patrick <Patrick.Bennett at inin.com>wrote: > So it caches the entire file? > > Doesn't it also have to examine and parse the backtrace to even determine > the file to load? Doing any of this on **every** task init bothers me – > particularly when I'm creating thousands upon thousands of task objects. > > Yeah, still a bad idea imo. > Perhaps try it and see... ? Dave -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://rubyforge.org/pipermail/rake-devel/attachments/20090604/03b2c802/attachment.html>

subset: commoncrawl


text:
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text:
OWPSB Noah's Ark
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Free UK delivery when you spend £10 or more
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If you're buying for a church, school or business, why not Buy Now Pay Later?Find Out More
OWPSB Noah's Ark
Full Product Description
OWPSB Noah's Ark. The ISBN for OWPSB Noah's Ark is 0710513625NOA.
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|1st January 2017
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text:
Winter may have barely begun, but Palo Alto Babe Ruth (PABR) baseball is already gearing up for 2012. Babe Ruth baseball offers youth ages 13 to 15 the challenge of playing on a full-size diamond, and the kind of competition that will help them take their skills to the next level.
Tryouts for the upcoming Babe Ruth 2012 season are scheduled for Jan. 21 and 29, depending on weather.
Visit pababeruth.org by Jan. 28 to register to participate in tryouts.
Players are drafted onto teams shortly after tryouts. To be considered for a team, a player must make at least one scheduled tryout.
To be eligible for Babe Ruth, players must be 13, but not older than 15, by May 1. Players must be a resident of Atherton, East Palo Alto, Menlo Park, Palo Alto, Portola Valley, Redwood City, Woodside, or certain areas of Los Altos Hills.
Thirteen-year-olds play in a "Prep" league made up o at least four teams. Fourteen- and 15-year-olds play together in an "Upper" league with seven or eight teams. Based on performance, some Prep league players will get the chance to extend their season and join the roster of an Upper league team.
Both Prep and Upper leagues play a short, busy season culminating in a championship tournament. Since many Upper league players also play for high school teams, their season begins after high school ball ends. The Prep league season starts earlier, and winds up as the Upper league begins play.
After the regular season, All Star teams are formed for each age group (13, 14, and 15), with the possibility of play in district, state, regional and national tournaments.
Go to pababeruth.org for more information.
This story contains 288 words.
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text:
Mentre Rugby Ball Size 5 - Red/BlackStock Code: E21943410
The Mentre Rugby Ball range is suitable for the youngest of rugby players. Built to different sizes to accommodate different age categories and player sizes, the rugby ball features the high quality construction seen in our professional level balls, but scaled to a size that younger players are able to handle more comfortably. It is built from three-ply rubber and has an outer panel to increase its reliability and durability with the rough handling it is sure to experience over a lifetime of practice and play.
- 60% Natural & 40% Syntheic
CCC Saver - £2.50 Delivery for this service is up to 7-10 working days.
UK Standard Delivery - £3.80 Delivery for this service is 3 - 5 working days.
Delivery to BFPO addresses is FREE.
Collect Plus - £3.99 (Orders Placed by 1pm Monday - Friday)
Online Order will be delivered to one of over 6000 Collect + stores for collection next working day.
(Deliveries into the network take place Monday -Saturday)
Express Delivery - £4.80 (Orders Placed by 1pm) - Delivery for this service is next working day for the UK Mainland, Highlands and Islands may take longer. Deliveries take place Monday to Friday only.
Saturday Delivery - £8.00 (Orders placed by 1pm on Fridays)
EU Standard Delivery - £8.00 - Delivery usually within 3-7 working days.
EU Express Delivery - £14.00 - Delivery usually within 1-3 working days after dispatch.
Worldwide Non EU - £18.00 - Delivery for this service is 7 -10 working days
For information on our International Deliveries & Return Procedure click here
For more information about how we take payments and keep them secure, please contact us.


text:
Using the "offers from" options you can filter merchants from regions which are most common in our database: the UK, Germany, Austria and Poland.
If a checkbox near a flag is selected, offers from merchants from that particular region will be displayed, otherwise they will not be visible.
If you select offers from "all regions", all offers from all merchants will be displayed. These incude offers from merchants in countries not listed here.
Colours: black, white Sizes: 6-15 (US)
Colours: black, silver Sizes: 40-50.5 (EU)
Sizes: 4-12, 13 UK (incl. half-sizes) Weight: 300g (UK 8)
Sizes: 3.5-8 UK
Sizes: 6-13.5 (UK)
Sizes: 42-47 (EU)
Colours: blue, black Sizes: 39 1/3-49 1/3 (EU) Weight: 680g (per pair) (42 2/3)
Colours: black, silver, green Sizes: 39-51.5 (EU)
Colours: pink, turquoise, white Sizes: 35.5-46 (EU)
Colours: black, orange, silver Sizes: 35.5-46 (EU)
Colours: purple, yellow, silver Sizes: 39-53 (EU)
Colours: green, black Sizes: 40-49 1/3 (EU) Weight: 320g
Colours: black, white Sizes: 38-49 (EU)
Colours: green, white, black Sizes: 38-49 (EU)
Colours: grey, green Sizes: 38-49 (EU)
Colours: black, white Sizes: 36-43 1/3 (EU)
Colours: white Sizes: 36-43 1/3 (EU)
Colours: purple, pink, silver Sizes: 36-43 (EU)
Colours: pink, white, grey Sizes: 36-43 (EU)
Sizes: 4-8 UK
Sizes: 6-13 UK
Colours: red, grey, silver Sizes: 36-43 (EU)
Colours: black, grey, pink Sizes: 36-42 (EU) Weight: 265g (EU 38)
Colours: pink, grey Sizes: 36-42 (EU) Weight: 265g (EU 38)


text:
4 posts tagged with Games by rachaelfaith.
Displaying 1 through 4 of 4.
Looking for fun, not-too-challenging 2-player games
What are the best games (both classic and new) for two people? Specifically, fun, not super challenging, about 30 minutes to 2 hours per session. Primarily seeking board games and card games, but video games for mobile or console are welcome too. [more inside]
What are some good, non-battery-draining iPhone/iPod Touch games?
I'll be on three flights in the next 11 days, and although I'd like to sleep through every flight, I doubt that'll happen. I have an iPhone 4 and a 3rd-gen iPod Touch at my disposal, so I'd like to throw some new, non-battery-killing games on them before I go. [more inside]
Replacement for WoW for a long-distance pair
Help me find a substitute for World of Warcraft to serve as common ground and entertainment for myself and my long-distance boyfriend. [more inside]
Mac user yearning for Windows 3.1 games
How can I play the classic Windows games in the Best of Microsoft Entertainment Pack (JezzBall, Chip's Challenge, SkiFree, PipeDream) on a Mac? [more inside]
Page: 1


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Business Name: PJ Tire & Auto
Address: 42-46 East Main Street
City, State Zip: Port Jervis, New York 12771
Mayor's Comments:
PORT JERVIS, NY – The Port Jervis Mayor's Office is pleased to announce that our Business of the Month for July 2016 is PJ Tire & Auto which is owned by Jason Dobbs operated by his sister Lisa Dobbs. The Dobb's family own and operate businesses on a main thoroughfare of this City and continue to make improvements to this area serving the Port Jervis community for over twenty five years. They offer prompt and friendly service, FREE lifetime rotation with the purchase of four tires and they offer a selection of brands to choose from. This business is located at 42-46 East Main St, Port Jervis, N.Y. Hours are 8:00 am to 4:00 pm – Monday – Friday; and 8:00 am to noon on Saturday. For more information stop in or call (845) 858-1012.


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"Is this cover for a queen size duvet or king? I don't want it too big or too small for my duvet."
I love this duvet and pillow cover set! It gives a fresh summer cottage look to my bedroom!...
Nautica Ventana Duvet Coverby Nautica
ITEM#: 14785487Stay warm with this attractive Nautica duvet cover. This duvet cover features an attractive plaid pattern.
- Plaid Duvet Cover with button details
- Thread count: 150
- Fabric detail: 100-percent cotton
- Closing: Button closure
- Style: Traditional
- Pattern: Plaid
- Color options: Charcoal grey
- Materials: 100-percent cotton Sateen
- Care instructions: Machine washable
- Duvet cover: 68 inches x 88 inches
- Duvet cover: 88 inches x 92 inches
Twin Dimensions
Full/Queen Dimensions
|Cotton, Sateen Cotton
|Thread Count Range
|Under 200 TC
|Full, Queen, Twin
|See Details
|Model Number
|Country of Origin
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I love this duvet and pillow cover set! It gives a fresh summer cottage look to my bedroom!Read More
Perfect for a Teen Boy
This cover is super nice and soft. Just what I would expect. Found the matching pillows at bed bath and beyond. The pillows were more than the duvet, but I wanted to complete the look. We paired it with jersy knit sheets and my son loves it.Read More
Great Duvet Cover
This is a great duvet cover. Nice material and thickness.Read More
Love love this duvet cover
Love this duvet...very good quality. I like the colors, I thought it would come with the pillow cases.Read More
Nice Quality
I was initially concerned with the thread count (150) but decided to try it anyway. I'm glad I did. The quality is excellent. Top surface has very nice appearance, fabric is nice and heavy, giving it a good look and feel, the bottom fabric is smooth and comfortable. It looks great and I think it will wear very well.Read More
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If you click on the options scroll down it will tell you each size available with the price. Thanks you
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Best Duvet Covers for Each Season
Best Duvet Covers for Each Season from Overstock.com. Our guides provide customers with information about the best duvet covers for each season.
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A duvet cover is a protective fabric cover that slips over your down comforter or duvet insert, just like how a pillowcase works with a pillow. If you have any kind of duvet insert or comforter, a duvet cover is a worthwhile investment for a number of reasons. Read on for helpful information about the benefits of having a duvet cover, including things to consider before buying one and how to use it best once you have it.
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The covering you put on your bed can affect the style of your bedroom as well as your comfort when you're sleeping. Read on to see whether a bedspread or comforter is the perfect choice for your bed.
3 Quick Tips for Better Sleep
When we get quality sleep, we have more energy to function our best in our day-to-day lives. But if you're like me, sometimes it's a struggle to get the kind of rest you need. These quick tips have helped me enjoy deeper, better sleep, which means I wake up refreshed and ready to go.
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Each month, direct to your email inbox, we'll send the best camping news, tips, recipes and more, to enhance the camping lifestyle that you love so much. Learn More
Enjoy 24/7 access to Certified RV Technicians for help with DIY repair with...
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Plan the perfect trip from home or on the road with the official KOA app. Learn More
Open All Year
Reserve: 800-562-7785
Info: 931-728-9777
586 Campground Road
Manchester, TN 37355Get Directions
From I-24 Exit 114, go 100 yards southeast on US 41, then 1/2 mile north on Campground Road. GPS: N35.462322, W86.053406Get Google Directions
Camper Rating 4.5 out of 5


text: Darth Vader's Audio WorkstationAdam Dachis11/05/12 10:30amFiled to: Featured WorkspaceWorkspacesWorkspaceDeskDesktopWorkspace Show and TellDarth VaderStar Wars30EditPromoteShare to KinjaToggle Conversation toolsGo to permalink You don't need color for a beautiful office, as reader Carolina di Paola proves with her awesome audio workstation. Everything is well-organized and in its place, plus a Darth Vader wall decal and an action figure add a little fun. Advertisement If you have a workspace of your own to show off, post them to #workspaceshowcase. Make sure any photos you include are at least 640x360. Keeping them to 16:9 helps, too! Include a little text about the stuff you used, how you came up with the design, and any other relevant details. If your clever organization and good design sense catches our eye, you might be the next featured workspace.Geekah Desktop | FlickrGear from Kinja DealsDave's Coffee Syrup: Nesquik for AdultsAirscape: Airtight Storage For Coffee and MoreSome Of Your Favorite Anker Gear Is Now 25% OffReply30 repliesLeave a reply


text:
|There's more than one way to do things
Re^2: Port Java code to Perl helpby Eliya (Vicar)
|on Apr 14, 2012 at 09:34 UTC ( #965053=note: print w/replies, xml )
|Need Help??
As pack 'H' is working from left to right on the passed string, you can simply say pack 'H2' (two hex characters make up one byte):
This would print "foobar", because the lower bytes 00 and ff are being ignored.
In Section Seekers of Perl Wisdom


text:
Looking to buy my first Jeep
Im looking to buy a Jeep in the Killeen are once I return to the States. I was hoping I could get some advice from a few people on what I should be looking for. I want a used one cause I cant really afford a new. I dont mind if it is modded. I want it to be my daily driver but I also want to get into off roading. Does anyone have any suggestions on what I should be looking for? Or does anyone know of a few good dealerships or ones I should stay away from?
Thanks for any advice.
I suggest starting with a Rubicon because Jeep's have great resale value, but you only get a very minor bump in price for aftermarket up-grades. To upgrade a non-Rubicon to the same level as a Rubicon will cost $$$ (read thousandS). By finding one from the factory already built you get your best bang for the buck in later resale value (if you decide to EVER sell it). If you find a non Rubican built to that level, there is a reason; it was used for rockcrawling. Not that that is bad, but for a D.D. you can probably find a Rubicon that has primarily been a mall crawler/street queen, and even bone stock has an amazing off-road capabilities. Then as you drive more off-road you can decide what up-grades (if any additional) are best for what you want to use the Jeep for.
When are you coming back? I'm actually leaving and THINKING of getting rid of mine while I'm gone.
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Move right into this beautifully updated all-brick Ranch home. Move right into this beautifully updated all-brick Ranch home, with central air, 3 Bedrooms & 1 Baths, large Living Room with gas fireplace, updated eat-in Kitchen and Dining Room leading to a large deck. All rooms on first floor have beautiful natural wood floors, recently refinished. Downstairs, a spacious carpeted family room with gas stove, energy efficient doors & windows, a large Laundry Room and abundant storage, leads to a Privacy Patio with deck access. Includes an attached two car garage & a new driveway, with lots of parking. Located in Lake Paulinskill, with numerous social oriented activities.
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Pork tenderloin, potato and parsnip mash, spinach, cider cream sauce
I poached the (vacuum sealed) loin until it was evenly pink, seasoned with salt and pepper and then seared it in a hot pan on all sides. Rested for 10 minutes.
Parsnips and potatoes boiled and then mashed with milk and butter, seasoned with salt, pepper and nutmeg.
Spinach wilted in butter, seasoned with salt, pepper and nutmeg.
Sauce made by deglazing the pan with cider, seasoned with salt, pepper and thyme, finished with double cream and the resting juices.
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Taken on March 26, 2011


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For anyone who's ever had a dream.
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Andrew Galati
Alex Schuster
Adan Berkowitz
yurij lojko
ben shurtleff
lauren nelson
The Chronicles of Amarilla: The Luchador, The Frijoles, and the Lobo
The Last of The Nemecans Part II: The Return of The Chair
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Sarepta Therapeutics, Inc. (NASDAQ:SRPT)
2012 Lazard Capital Markets Healthcare Conference
November 11, 2012 4:30 PM ET
Chris Garabedian – President and CEO
We're going to get started. I'm Bill (Inaudible) biotech analyst Lazard Capital Markets. I thank everybody for attending the 9th annual LCM Healthcare Conference. Hopefully today has been valuable to you and hopefully you'll come tomorrow and that will be valuable as well. We are pleased to have Chris Garabedian and probably racked up some serious frequent flier miles in the last month and a half and somebody who is obviously very popular in the investment community with some of the data that they recently put out on Eteplirsen for treating Duchenne. So Chris, thanks very much for participating and for your presentation.
Chris Garabedian
Thanks Bill and thanks to Lazard for the invitation and well done some great research following the company. We appreciate that. I'd like to talk to you about Sarepta Therapeutics. We are an RNA based technology, but we think it's differentiated from other approaches and we show this in the clinic, most notably with our Duchenne Muscular Dystrophy product and I'd like to talk to you about some recent data we shared. I'm going to be making some forward looking statements so please refer to your SEC documents on Sarepta to understand the risk factors associated with the company.
Our proprietary pipeline is focused on Duchenne Muscular Dystrophy program is the drug Eteplirsen where we just announced 48 week data from our phase two study and I'll reveal those to you today. We also have a couple of other follow on compounds. This is a genetic based disease. It's very fragmented and requires many drugs to treat all of the potential patients that would be amenable to our technology. And so we're focused on bringing other Duchenne products with our safe technology through the clinic.
We also have an infectious disease portfolio, but largely elder funded or is currently funded by the government and department of defense, most specifically and I'll be talking – I won't be talking about the infectious disease program today, but I will say that our novel virus program is an active program in development that has shown very good activity on survival in non-human primates and has been shown to be safe in single setting dose. We are preparing for multiple setting dose that will take place next year.
So Duchenne is really a devastating neuromuscular disease. It affects mostly brains (inaudible) connect chromosome disease and it's a very progressive disease. It starts with diagnosis usually by the age of three to five years of age. It typically leads to a level of progression of loss of ambulation until their pre-teens or early teen years where they'll require a wheelchair and then they start to lose their basal muscle function, their pulmonary and cardiac function start to see this congestial decline.
They won't live beyond the age of 30 and so this is largely caused by their lack of the essential protein that's found in healthy muscle called dystrophin. And so what we're attempting to do with our product and our technology is to repair the mutations that occur in the dystrophin gene that render them unable to translate and produce the protein. And so what you see on the right here is, on the top cell you see what Duchenne Muscular Dystrophy tissue looks like when say for Dystrophy you hardly see any discernible dystrophin. On the bottom is the healthy muscle tissue, what our muscles would look like with 100% dystrophin part of the fabric.
So Eteplirsen is the molecule that I'm going to be talking about today and this is a RNA antisense oligomer type that has a very different backbone chemistry than other RNA antisense approaches and really different than most of the RNA applications we see out there, whether it's SRNA or RNAi or microRNA. It does not appear to the (inaudible) chemistry, the nucleic acid type structure negatively charged which typically interacts with other host proteins. It has inflammatory effects. It basically produces these off target effects that limit their ability to get to a dose window that phase.
And so it works in DMD by directing alternative splicing that we call exon skipping and I'll explain that in a minute. It administers systemically through IV infusions weekly. This is the DMD application I'm referring to. The PMO here, this is the Phosphorodiamidate Morpholino Oligomer that I'm referring to is neutrally charged and the plasma half life has very attractive drug like properties. It has a short plasma half-life, two to six hours but that exposure to in this case the muscle cells get uptick and produces Dystrophin has a very much longer half-life. It can be two to four weeks, the Dystrophin half-life and potentially we might see a longer half life in compartments or inside the cell.
It's close to the kidney. We've seen that it occurred intact in the urine normal tab light. We've not seen any antibody or imminent genetic response to the drug and in the current DMD tests we've tested this drug up to 15mg/kg weekly in patients that we saw low treatment adverse events, low lab abnormalities, no signals of toxicity through four weeks treatment.
The mechanism of action that I described, the exon skipping or direct alternative splicing is really attending to repair the lesion that occurs in the Dystrophin gene in these patients. Now, lesions along the gene can manifest itself in two ways. It can produce a Duchenne patient that is a much more severe phenotype. It's degenerative embedded with 100% fatal. Typically the majority of patients lose the ability to walk by age 12 and it's characterized by an outer frame deletion that renders them unable to reach through and produce the protein.
This similar dilution in the gene of in frame. It produces a Becker muscular dystrophin phenotype. This is a milder disease and often times there's a chain ambulation until late adulthood. Often times they're not even aware they have a muscular dystrophy as they grow into adult life. What we're essentially doing is converting a Duchenne genotype into a Becker genotype and the hope phenotype to produce a milder disease. And by doing that, we're able to restore the legal frame and allow these patients to produce a dystrophin protein albeit a truncular protein like we see in Becker, but a functional dystrophin protein nonetheless.
This is just more specifically an example of a patient in our studies that would have, let's say 49, 50 deletion in the gene. You see that it's out of frame. So the code-ons don't match up and we understand what the bad actor is in any specific Duchenne genotype. In this case it's the silence exon 51 or hybrid frame out of the reading frame we're able to create an in frame deletion and restore. So we're converting a 40, 50 deletion to a 49, 51 deletion which is something you see in a Becker muscular dystrophy patient.
And we see that we could produce a protein in an earlier UK study. This was a phase 1C study where we were able to produce novel dystrophin via the muscle biopsies and immunofluorescent staining. Here are some examples of the vessel RT-PCR and the immunofluorescent staining we did a patient in the study. But we weren't satisfied that we've achieved the optimum levels of dystrophin that we thought would translate to a clinical benefit. So these doses went up to – from 0.5mg/kg to 20 mg/kg and within 20mg/kg were more consistently producing novel dystrophin.
So really we want to understand is how do we produce more and if you look at the first 24 weeks of this scheme here, of the study design, we did that by staggering the biopsies and to try to understand the relationship between dose and duration. So we wanted to look at a higher dose, 50mg/kg at a short timeframe, 12 weeks consistent with our UK study, but we also wanted to look at a lower dose study mg/kg over a longer duration, 24 weeks to see if dystrophin would be produced.
What we learned from the first 24 weeks is that we don't see meaningful levels of dystrophin until 34 weeks, despite looking at a higher dose at 12 weeks, they had on average is 0.8% dystrophin positive fibers while the 24 week 30mg had over 20% dystrophin positive fibers. Now, we continued these patients on and rolled the placebo patients over and we scheduled a third biopsy you see here at 48 weeks. And I'm going to show some of that data which was very encouraging with the follow up. Just as background, these were the baseline characteristics in our study. Again we had great conformity around age and the six minute walk baseline, with the exception of you'll notice that we had a slightly older mid age and a 30mg group.
They were taller on average in the 30mg group and they had a lower six minute baseline. This is important to highlight because there were two boys that we have now disclosed were homozygous twins that basically had the lowest six minute walk baseline scores. They were the tallest in the study and that's notable because height and taller height has been a contributor to rapid decline on ambulation and they also were slightly older. Although they weren't the oldest in this study, they were in the older end of the range. So you'll notice the study in their groups were important because those two boys who lost ambulation that I'll describe in a moment were in that 30mg group.
I just want to highlight, I'll be showing a lot of dystrophin data. We had a very rigorous methodology to collect the dystrophin and measure the dystrophin. This was a blinded process. So the reviewer did not know what they were looking at in the blinded phase, whether they were looking at treated or a placebo patient, whether it's pre-treatment or post-treatment. We also in the 48 week put some additional slides for review to not allow them to understand what they were looking and they were blinded also for dose in the 48 week timeframe. But ultimately, these were very robust analysis and that they used multiple samples.
We took a long tissue sample from the belly of the bicep. We sliced that into, in the case of the immunofluorescence, 12 slices for each block of two blocks to 24 slices just to do the immunofluorescence and we took an average of that and then we did that again at the 24 week timeframe and the 48 week timeframe. So using the averages, we also factored out the baseline dystrophin levels because in this process you can see some noise or reverting fibers present at baseline. And so we wanted to take a conservative approach and factor that out so that we really understood what is the novel dystrophin positive fibers that we're creating. We didn't want to artificially fail.
So we think it's very important to have baseline dystrophin biopsy samples to measure against or to calibrate what it should look like in a Duchenne patient. So just want to highlight the rigor that went into the dystrophin analysis. And this was the overall summary table. We shared in October of what we showed at 48 weeks. You see the top numbers here represent after 48 weeks of the Eteplirsen treatment. We showed 47% dystrophin positive fibers and I'll show you some fibers that reflect an example of what this looks like in the muscle biopsy.
We had seemingly no dose response here. The 30mg actually numerically had higher dystrophin positive fibers than 50mg, but generally these were not different from each other. They were both particularly different from the baseline and we think that generally this says that even 30mg over a long enough duration of therapy produces very robust levels as much as we might see with 50mg.
When we look at the placebo crossover patients, these were just four patients after 24 weeks of treatment. Again comparable levels steady 8% after 24 weeks of treatment dystrophin positive fibers and again because these were in two, we didn't have specific scores on the subgroup, but numerically 50mg did a little better than 30mg. but generally this tells us that the dystrophin levels were higher at 48 weeks over 24 weeks and we don't seem to see a real dose response in having 50 mg produced significantly more dystrophin.
These are the individual patient scores and again, because the first part of the study we staggered the biopsy so you have to look at the color key here, but you see notably on the left hand side the 30mg group where we did have dystrophin present at 24 weeks, this was before patients where we could understand does dystrophin increase with continued dosing. And this is where it was very encouraging in that every one of those patients showed increased dystrophin and was consistent.
Those range from the average of about 28% to 31% increased dystrophin positive fibers from 24 to 48 weeks. And again I'll just remind you that the two non-ambulant boys were in this cohort. So even in a non-ambulance setting, we're showing that dystrophin can be present. This structure will be taken safely. These boys continued to take the drug and they showed increases consistent with what we saw in the ambulatory population. And then you'll see, look there are other factors, host factors and maybe sampling variability that leads to some of the fluctuations across the individual patients.
But in general, all of them even the 24-week patient showed about a 30% Dystrophin positive fibers, up to 60% Dystrophin positive fibers across the cohort.
And these are really encouraging to see in that you can visually and qualitatively see the difference in the biopsy sample of what the pre-treated biopsy uses the 30 milligram groups, that you see the Dystrophin basically localizing at the cell membrane in the Sarcolemma, which is exactly where we want to see it. And then you see in the photo where we treat the cohort of the same patients, you really start to see the additional distribution and well diffused Dystrophins throughout the muscle biopsy. So this was very encouraging.
If you look at this on a computer we have these slides on our website. You really start to see the Dystrophin pop in a dark room if you are looking at a well at screen. And here we wanted to show – again, we are showing every single patient in our study, pre and post treatment. We think that is important in that we receive a consistency across each patient – again, on the left hand side you can see the 50 milligram group at 48 weeks and then here you see the placebo crossover groups 50 versus 30.
Here we show a 6-Minute Walk. So we did collect a clinical outcome and had the primary clinical measure of 6-Minute Walk test captured and what we've done here is we have taken those two boys that I described. These were the Monozygotic twins who went non-ambulance shortly after and whom in the study before we had a chance for the drug to produce Dystrophin, they had already, were well on their way to losing ambulation. We have now – this is our modified intent to treat where we have combined the 50 milligram group and the 30 milligram group into the treatment cohort and we compare that to the placebo group that had delayed treatment.
And as I mentioned, the Dystrophin we've produced was fairly consistent across 30 and 50 milligrams. So we wanted to understand if you combined those patients who are still ambulant producing those levels of Dystrophin, how do they perform as a group compared to the placebo delayed treatment.
And again here we're presenting this modified intent to treat which led to a 67 meter differential at 48 weeks with a P-Value of 0.001. And again this is somewhere near the graph and that we are combining and including the 30 milligram. We have reported previously that the 50 milligram had a better treatment effect than the 30 but we don't think that that means 30 is not responding to the drug. In fact, we do see a differential and although 30, the two patients in 30 didn't hit the physical significance compared to placebo. When they are combined with our treated group we do retain the P-Value in our modified intent to treat. So we thought it was important to recognize that the 30 milligram group even when they are included in the treatment again leads to a good benefit over the placebo delayed treatment group.
And what we wanted to highlight was for those that are new to the story, I shared with how the Dystrophin was delayed in seeing those meaningful levels. At 12 weeks at the highest phase we saw 0.8% Dystrophin positive fibers. So we know that sometime between week 12 and week 24 is when we would expect the Dystrophin to materialize in the muscle tissue and to be at meaningful levels. So what you can see here is when we would expect Dystrophin to be present in the muscles is the shaded part for both the treatment group and for the delayed placebo group. And so you see until we were able to produce Dystrophin you see the placebo group was on that progressive decline that we expected and they seem to have stabilized between weeks 36 and week 48.
So again we are very encouraged by these data, the goal of therapy is to maintain stability in this population that has this progressive disease or slow the progression of the disease. And we think if you start earlier before they started to lose progression that both work for the ability to keep them in a fairly good ambulance state for a longer duration of time.
And we'd just like to highlight that the two boys who were non-ambulant, we don't think that that means that the drug is not having an effect, we think that it was too late to show an effect on an ambulatory measure but non-ambulatory measures such as pulmonary function tests are important and we continue to follow them in these patients. We are just showing in a few that after 48 weeks the two twins who were non-ambulant have maintained their pulmonary function. And the reason we picked this out is because what we typical see as fairly good healthy pulmonary function in an ambulatory population but after they go non-ambulant you start to see this compupentory decline. And so one of the highlights that we've not seen any signal of decline on the pulmonary function we'll continue to follow them out further. We are also looking at muscle strength and nine hole tech tests and other non-ambulatory measures that we think are relatively insensitive of their able and shorter duration but over time we think those are going to become meaningful of maintaining the level of function on some of these other ambulatory measures.
And then we just showed this for – to address any questions about where one or two patients driving the treatment effect and this really breaks down the subgroup analysis and our modified intent to treat pretty finitely. And if you refer to our press releases about 46 weeks and 48 weeks in July 24, October 3, you'll see we get baseline characteristic even of the subgroup. So if you really start to dig into this you'll really understand that this was not limited to one or two patients who did better on treatment. That it was really a robust analysis across these various subgroups.
And again we just wanted to highlight how thorough the analysis was on our safety parameter and labs. And again we have seen no evidence of toxicity across all of these types of measures and we continue to follow these to see normality or stability on many of these measures and so we continue to dose all of these patients, this is a long term safety and efficacy study and so we intend to follow these patients indefinitely as long as this program continues to move forward. And so we look forward to analyzing further data at future time points.
And this is our treatment emerging adverse events slides that now look at those that were dosed for Eteplirsen 24 weeks in total. So these was all 12 patients after 24 weeks of treatment at Eteplirsen. We have eight patients now that have been on Eteplirsen for 48 weeks, that's the second column and then we have that placebo group for 24 weeks to compare what were the adverse events that were coming up in the first 24 weeks in the placebo. But importantly, there's been no treatment related adverse events and we've been well tolerated, no series adverse events in the study or discontinuations, no treatment related changes on safety lab parameters including several level-specific enzyme work related to the kidneys, so that was very important to look at. And then no proteinuria or change in blood coagulation profiles or thrombocytopenia that has been observed, which has been observed with other chemistries in the R&A state.
Just to discuss briefly upcoming activities, in the fourth quarter we'll be preparing briefing documents with the 48 week phase IIb data. By the end of the year we will request end of phase 2 meeting with the FDA, this will be calendered in the first quarter of '13, where we will meet with the FDA to discuss the confirmatory study and the fastest path to approval. In the – really next year is a planning year to prepare for whatever we learn for these FDA meetings to plan for those confirmatory study or studies and as well as preparing manufacturing scale up. So in the second to third quarters of next year, we will be preparing manufacturing scale up, we'll have our CMC meeting with the FDA, we'll be producing drug materials for our confirmatory trial, we're doing protocol development, site selection, patient identification and pre-screening. We are in the first quarter of '14 as well we expect to have IRB approvals and to initiate patient dosing and whatever confirmatory study we agree upon with the FDA.
And we think this dataset that I've shared with you is highly reproducible across other Exon-Skipping targets in DMD. We already have two collaborations with academia and government funding. Just a production on 45 and Exon 50. We've been working additional collaborations on Exon 52 and Exon 44 that will hope will come to fruition and we think that these top five Exons represent about 45% of the Exon-Skipping amenable population. And we think if we see consistent results, standard dosing, similar pharmacokinetics and safety profile which manufacture the same way and we see consistent responses that this could enable what we hope will be a class approval whether were the Exons, which in feasible to do clinical safety and efficacy studies, both there is a mechanism with the EMA and the FDA to get a broad class approval.
And in summary, our financials. We have 25.5 million shares outstanding that we disclosed on our last earnings call. This includes a recent drawdown on an ATM that gave us a $57.4 million cash balance as of November 7 a couple of weeks ago. Our current share price, closing price as of yesterday was $27 which equates to about a $690 million Market Cap and again our guidance for 2012 which we reiterated at the last earnings call was $37 million to $43 million, we are overcoming the low end of the range on the revenue because of a calculation of our bill of contract and a delay in some of our marble revenues to result in an operating loss which is still within guidance of $25 million to $30 million for calendar year of 2012.
So that's all I have and I think we have a little bit of time for questions.
Question-and-Answer Session
Unidentified analyst
So yeah, so you biopsy the biceps as well?
Chris Garabedian
Yeah. We biopsy the bicep muscle, we define that a priority. We did all 380 biceps for the baseline and the 24 weeks or 12 week time point. For the third we had to go to another biopsy – so rather bicep. And we gave them an option but they ended up getting it from a healthier portion. So one where they didn't go and surgically before. We didn't want them to go into the safe spot, potential scoring or anything like that. So we had a fresh bicep sample for the third 48-week biopsy. But we usually get that is that this systematically delivered drug. We know that it works with local injection and we wanted to make sure we affected a large extremity muscle, that's what we are trying to impact more most of all. And we didn't want to do it in the quadriceps because they had walking tests, a lot of function tests that they needed their legs more importantly on and we didn't want to have any surgery or anything like that to disrupt that. We felt the biceps was a really good proxy for a large extremity muscle groups.
Unidentified analyst
I do want if you could have thought that most of the data points do better localization in both the quad and calf and diaphragm, triceps or biceps. So you could expect higher levels of Dystrophin expression I would assume in those other working muscle groups, right?
Chris Garabedian
We'll, we think it's a good proxy for what's going on in the rest of the musculature. I don't know if there's more dystrophin we'll see. We go into the belly of the bicep as opposed to let's say the anterior tibia ligament, right? That's known to be a very leaky muscle, right? They're constantly breaking down that muscle. So if you wanted to try to get a higher Dystrophin level, you might pick that because then you'll get better uptake of the drug, leak your muscle tissue, that may artificial inflate what your Dystrophin levels might be versus going into the belly of a large extremity muscle. But they are human subject, so we can't unfortunately get multiple surgical biopsies. So we have to use this as a proxy to represent what we think is going on in the rest of musculature.
Unidentified analyst
And so what I would -- just in your October slides, I thought we had western blot data. So can you relate to us the Dystrophin percentage protein…?
Chris Garabedian
Yeah. We've not reported any quantification. In fact, we don't believe that western are evenly quantifiable and so we really did it just to show evidence that we are producing the protein by other means. We did the same thing at RTCR. We don't try to quantify those methods because they are very variable given the lab-to-lab that have different results. The staining -- there's a lot of art in that and we think that there are not the most quantifiable. The reason that we picked A priority Dystrophin positive fibers to immunofluorescents is after talking to leaders in the field, we noticed some debate about this but we felt that the stronger arguments were around actually looking at what is going on in the muscle. Is it localizing where you want to see it, how distributed and how well diffuse is it across a swap of muscle tissue and wanted repeated like a western value of one value. This has 24 for each time point. Any methodology to get what you are actually being novelly produced. So we – prospect of defining if for a reason but we understand we want to be – our little evidences to support the data use in here.
Unidentified analyst
Thank you.
Chris Garabedian
Any other questions?
Unidentified analyst
Why will it take a year to sort of figure out what the next steps are. Is it complicated with the FDA in terms of what end points would look like for a traditional trial?
Chris Garabedian
We'll, doing with the FDA we don't know what that confirm our study is going to look like but a lot of this is preparing not only the protocol development and the site selection and all the things that are going to preparing well for an important confirmatory or a pivotal study, but it's also producing the drug to baseless patients. We've been small scale production to support our ongoing trial. We want to get to the next scale of production to support clinical trials with this drug. And this is a campaign, you have to do process validation, you have to make sure that the process can translate to the higher scale, you have to work with – take transfers to the CMOs that we are working with and importantly, unless we hear otherwise from the FDA, three validated batches using GMP conditions with three months fidelity of which we have to submit to the FDA for review before we get release of the drug product. And so we are trying not to cut that too close.
Unidentified analyst
Okay. Thank you for attending.
Chris Garabedian
I appreciate it.
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EAST stands for "Epistemology and Argumentation in South Asia and Tibet". This resource collects and presents bibliographical, prosopographical and terminological information on epistemology and argumentation in South Asia and Tibet, covering a time-span from the fifth century CE until, essentially, the present day. It is being developed under the umbrella of the Heidelberg Research Architecture (HRA), the digital humanities division of the Cluster of Excellence "Asia and Europe in a Global Context" of the University of Heidelberg, supported by the German Research Foundation (DFG).
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