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Hypoglycaemic and Hypotensive Effects of Ficus Exasperata Vahl. (Moraceae) Leaf Aqueous Extract in Rats
Adewole, Stephen O
Adenowo, TK
Naicker, Thajasvarie
Ojewole, John A O
African Journal of Traditional, Complementary, and Alternative Medicines
The hypotensive and hypoglycaemic effects of Ficus exasperata (Vahl) (family: Moraceae) leaf aqueous extract (FEE) were investigated in experimental rat models. In this study, spontaneously-hypertensive rats (SHR) (type 1 diabetes), obese Zucker (type 2 diabetes) and Wistar rats were used. Three (A, B and C) groups of rats, each group consisting of 10 rats, were used. Group A Wistar rats received distilled water in quantities equivalent to the volume of streptozotocin (STZ) and FEE administered intraperitoneally to treated rats. Diabetes mellitus was induced in the SHR group B rats by multiple low-dose (MLD) intraperitoneal injections of STZ (40 mg/kg body weight) to induce type 1 diabetes. The animals in group C were the obese Zucker rats with non-insulin-independent diabetes mellitus (NDDM) (type 2 diabetes) on genetic basis. F. exasperata leaf aqueous extract (FEE, 100 mg/kg/day p.o.) was administered orally by orogastric intubation to fasted Groups B and C rats. In groups B and C rats, administration of FEE commenced 4 weeks post STZ injection, and continued for the next 4 consecutive weeks. Group A rats gave normal biochemical and morphological findings. Group B rats exhibited pronounced polyuria, hypoinsulinaemia, hyperlipidaemia and hyperglycaemia. These findings were also observed in group C rats, except that there was hyperinsilinaemia. Histopathological study of the aortic blood vessels showed extensive collagen fiber formation as well as perivascular fibrosis in both groups B and C rats. Four weeks of oral administration of F. exasperata leaf aqueous extract to diabetic groups of rats decreased blood glucose, blood pressure and lipid profiles. Administration of FEE (100 mg/kg p.o.) also restored the microanatomy of the blood vessels to almost normal levels. The findings of this study suggest that F. exasperata leaf aqueous extract possesses hypoglycaemic, hypotensive and hypolipidaemic properties. These findings lend biomedical and pharmacological support to the folkloric, ethnomedical uses of the plant in the management and/or control of diabetes and hypertension among the Yoruba-speaking people of Western Nigeria.
Ficus exasperata (Vahl) leaf aqueous extract; streptozotocin; rats; hypoglycaemic; hypotensive and hypolipidaemic properties
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Protective Effects of Annona Muricata Linn. (Annonaceae) Leaf Aqueous Extract on Serum Lipid Profiles and Oxidative Stress in Hepatocytes of Streptozotocin-Treated Diabetic Rats
Adewole, Stephen O
Ojewole, John A O
African Journal of Traditional, Complementary, and Alternative Medicines
Extracts from various morphological parts of Annona muricata Linn. (Annonaceae) are widely used medicinally in many parts of the world for the management, control and/or treatment of a plethora of human ailments, including diabetes mellitus (DM). The present study was undertaken to investigate the possible protective effects of A. muricata leaf aqueous extract (AME) in rat experimental paradigms of DM. The animals used were broadly divided into four (A, B, C and D) experimental groups. Group A rats served as 'control' animals and received distilled water in quantities equivalent to the administered volumes of AME and reference drugs' solutions intraperitoneally. Diabetes mellitus was induced in Groups B and C rats by intraperitoneal injections of streptozotocin (STZ, 70 mg kg−1). Group C rats were additionally treated with AME (100 mg kg−1 day−1, p.o.) as from day 3 post STZ injection, for four consecutive weeks. Group D rats received AME (100 mg kg−1 day−1 p.o.) only for four weeks. Post-euthanization, hepatic tissues were excised and processed biochemically for antioxidant enzymes and lipid profiles, such as catalase (CAT), reactive oxygen species (ROS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), thiobarbituric acid reactive substances (TBARS), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL), respectively. Treatment of Groups B and C rats with STZ (70 mg kg−1 i. p.) resulted in hyperglycaemia, hypoinsulinaemia, and increased TBARS, ROS, TC, TG and LDL levels. STZ treatment also significantly decreased (p<0.05) CAT, GSH, SOD, GSH-Px activities, and HDL levels. AME-treated Groups C and D rats showed significant decrease (p<0.05) in elevated blood glucose, ROS, TBARS, TC, TG and LDL. Furthermore, AME treatment significantly increased (p<0.05) antioxidant enzymes' activities, as well as serum insulin levels. The findings of this laboratory animal study suggest that A. muricata extract has a protective, beneficial effect on hepatic tissues subjected to STZ-induced oxidative stress, possibly by decreasing lipid peroxidation and indirectly enhancing production of insulin and endogenous antioxidants.
Annona muricata leaf; Aqueous extract; Lipid profiles; Streptozotocin; Oxidative stress; Antioxidants
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Artocarpus Communis Forst. Root-Bark Aqueous Extract- and Streptozotocin-Induced Ultrastructural and Metabolic Changes in Hepatic Tissues of Wistar Rats
Adewole, Stephen O
Ojewole, John A O
African Journal of Traditional, Complementary, and Alternative Medicines
Decoctions and infusions of Artocarpus communis (Forst.) (family: Moraceae) root-bark are commonly used traditionally among the Yoruba-speaking people of Western Nigeria as folk remedies for the management, control and/or treatment of an array of human diseases, including type 2, adult-onset diabetes mellitus. Although numerous bioactive flavonoids have been isolated from the roots, stem-bark and leaves of A. communis, to the best of our knowledge, the effects of the plant's root-bark extract on animal model of diabetes mellitus and on liver tissues have hitherto, not been reported in the biomedical literature. In view of this, the present study was undertaken to investigate the glycaemic effect of, and hepatic tissue ultrastructural, morphological and metabolic changes induced by, A. communis root-bark aqueous extract (ACE) in Wistar rats. The ultrastructural, morphological and metabolic effects of ACE have been compared with those induced by streptozotocin (STZ) in rat experimental paradigms. Four groups (A, B, C and D) of Wistar rats, each group containing 10 rats, were used. Diabetes mellitus was induced in the diabetic groups B and C animals by intraperitoneal injections of STZ (75 mg/kg body weight), while group A rats received A. communis root-bark aqueous extract (ACE, 100 mg/kg body weight, i.p.) alone. Control group D rats received distilled water in quantities equivalent to the volume of ACE administered intraperitoneally. The rats in group C were additionally treated with ACE (100 mg/kg body weight i. p.) daily from day 3 to day 10 after STZ treatment. Hepatic glucokinase, hexokinase, glutamate dehydrogenase, succinate dehydrogenase, β-hydroxybutyrate dehydrogenase, serum insulin and blood glucose levels of the animals were measured and recorded before and after ACE, STZ and STZ+ACE treatments. Hepatic tissues were also processed for transmission electron microscopy. Electron microscopic examinations showed toxic, deleterious alterations in the ultrastructures of groups A, B and C hepatic cells, the most prominent deleterious effects being on the hepatocytes. Ultrastructural changes observed within the hepatocytes of groups A, B and C rats include disrupted mitochondria with increase in lipid droplets, extensive hepatocellular vacuolation, scanty rough endoplasmic reticulum (RER) and ribosomes. Large glycogen clusters were also noticed displacing the mitochondria and RER in group A rats. Group A rats also developed significant hyperglycemia (p<0.05) immediately after ACE administration, while groups B and C rats developed hyperglycemia 24 hours after STZ treatment. When compared with the control group D rats, the activities of all the three subsystems were disrupted, leading to overall inhibition of oxidative phosphorylation of the liver mitochondria in groups A, B and C rats, but remain normal in the untreated group D control rats. The findings of the present study indicate that A. communis root-bark aqueous extract induces hyperglycaemia in the experimental animal model used, and that the plant's extract disrupts the ultrastructural characteristics and architecture of hepatocytes as well as oxidative energy metabolism.
Artocarpus communis; streptozotocin; hyperglycaemic effects; hepatic tissues; ultrastructural and metabolic changes
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Protective Effect of Quercetin on the Morphology of Pancreatic β-Cells of Streptozotocin-Treated Diabetic Rats
Adewole, Stephen O
Caxton-Martins, Ezekiel A
Ojewole, John A O
African Journal of Traditional, Complementary, and Alternative Medicines
This study was undertaken to investigate the protective effects of quercetin (QCT) on the morphology of pancreatic β-cells against diabetes mellitus and oxidative stress experimentally-induced by streptozotocin (STZ) treatment in Wistar rats. Fifty male and female Wistar rats (200–250 g) were randomly divided into three experimental groups (i. e., control, STZ-treated, and STZ + Quercetin-treated groups). Diabetes was induced in the diabetic groups (B and C) of animals, by a single intraperitoneal injection of STZ (75 mg/kg), while each of the rats in the 'control' group received equal volume of citrate buffer (pH 6.3) solution intraperitoneally. In group C rats, quercetin (QCT, 25 mg/kg/day i. p.) was injected daily for 3 days prior to STZ treatment, and QCT administration continued until the end of the study period (30 days). Diabetes mellitus was confirmed by using Bayer's Glucometer Elite® and compatible blood glucose test strips. The rats were sacrificed serially until the end of the study period (after 30 days). The pancreases of the sacrificed rats were excised and randomly processed for histological staining and biochemical assays for antioxidant enzymes [such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and serum nitric oxide (NO)]. In the diabetic state, pancreatic β-cells of STZ-treated group B rats histologically demonstrated an early chromatin aggregation, cytoplasmic vesiculation in the central β-cells, nuclear shrinkage, and lysis of β-cells with distortion of granules. The morphology of QCT-treated rats' pancreases showed viable cellularity with distinct β-cell mass. STZ treatment significantly decreased (p<0.05) GSHPx, SOD, CAT and pancreatic insulin content. However, STZ treatment increased blood glucose concentrations, MDA and serum NO. The QCT-treated group of animals showed a significant decrease (p<0.05) in elevated blood glucose, MDA and NO. Furthermore, QCT treatment significantly increased (p<0.05) antioxidant enzymes' activities, as well as pancreatic insulin contents. Quercetin (QCT) treatment protected and preserved pancreatic β-cell architecture and integrity. In conclusion, the findings of the present experimental animal study indicate that QCT treatment has beneficial effects on pancreatic tissues subjected to STZ-induced oxidative stress by directly quenching lipid peroxides and indirectly enhancing production of endogenous antioxidants.
Quercetin; Streptozotocin; Antioxidant enzymes; Pancreatic β-cell
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Center Republican
CCC welcomes new members to board
It was light business and light lunch at a recent Coal Conversion Counties board of director meeting in Hazen.
Posted 7/25/12 (Wed) read more »
Cross Ranch Park makes an exquisite comeback
Last year at this time, much of the Cross Ranch State Park, located six miles southeast of Hensler, was underwater from the flooding Missouri River.
Posted 7/25/12 (Wed) read more »
New water, budget cuts and compromise for City Council
The Center City Council had many topics on the table when they met July 9.
Posted 7/18/12 (Wed) read more »
Corn, wheat and the march of the weevils
There is no doubt that the past few years have not been easy for Oliver County farmers. However, this year's harvest seems to be shaping up nicely.
Posted 7/18/12 (Wed) read more »
JP/L wins at McQuades tourney
The odds weren't in favor of Jimmy's Pizza/Longshots on the first day of the McQuades Softball Tournament. A bird pooped on one player and another player broke her nose during the team's first game. JPL battled through poop and injuries to capture the McQuades Rec three division title.
Posted 7/11/12 (Wed) read more »
Temporary liquor license problem close to solution
One of the hottest topics discussed at the July 6 County Commission meeting were two pending temporary liquor licenses. The commission expressed some concern as to allow the catering of these services from businesses located outside the county. Their chief concern was extensive catering might harm some of the small business in the community. Commissioners also expressed understanding however, that individuals had a right to choose whom they give their business. The conversation then turned to compromises.
Posted 7/11/12 (Wed) read more »
Cattle shot and killed in SE Oliver County
Nine dead animals were found in the evening of July 4 in the pastures of two Oliver County ranchers.
Posted 7/11/12 (Wed) read more »
Christmann opts to campaign
Following an announcement recently that District 33 Sen. Randel Christmann, Hazen, could be appointed to the North Dakota Public Service Commission due to a change in the North Dakota Constitution, Christmann announced he would rather seek election to the vacant seat in November.
Posted 7/03/12 (Tue) read more »
Chippin' some flint at KRIV
There were no Wal-Marts in the 1700s, Marv Bechler pointed out, as he chipped away at a jagged chunk of Knife River flint.
Posted 7/03/12 (Tue) read more »
West River Telecom details successful year
The words of former West River Telecom manager Dale Albers 40 years ago still ring true today for WRT: "We're optimistic as heck."
Posted 6/27/12 (Wed) read more »

subset: commoncrawl


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Written on: 28/06/2003 by mel. (1 review written)
Good Points
polyphonic ringtones + hi fi ringtones (have voices)
Bad Points
ringtones do not work when downloaded
can't find many websites that do ringtones for it
boring fasias
General Comments
i like the phone but i would like to download wall papers and ringtones for it but i cannot find any. but i like how it looks like a game boy a bit. buy this phone if you are not bothered about downloading more ringtones and stuff like that
As rated by our community of reviewers
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Written by gguzmanr


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What's for dinner?
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Join Date: Apr 2004
Posts: 13,163
Tuesday, October 16, 2012 at 02:19PM
Never had their burritos, but they have a great bakery.
You go in and fill out a ticket (carbon copy) with what you want and give one to the person making the food and take the other up to pay then come back and pick it up. You can get grilled chicken, shredded chicken, carne asada, carnitas, rock shrimp, grilled veggies, grilled tofu, bacon or chorizo for the "meats" and your choice of black, pinto or refried beans, brown or Mexican rice, different salsas, tomatoes, cilantro, lettuce, onions or cheese and white or wheat tortilla. They also have nachos, quesadillas, taco salad, tostadas, breakfast burritos, and tacos. They have different sizes and we got the smallest for $5 and it was huge. I can't imagine what the grande size looks like.
Byron,GA> Charleston, SC> Jacksonville, FL> Guilford, CT> Rohnert Park, CA! A southern drawl in sunny Cali! .
The amount of time from slipping on the peel and landing on the pavement is exactly one bananosecond.
I do have a secret yen for pink in unexpected places.
ninja dog
I've decided that I'll never get down to my original weight, and I'm OK with that--After all, 8 pounds 2 oz. is just not realistic.


text:
24 CFR 241.545 - Covenant against liens.
Beta! The text on the eCFR tab represents the unofficial eCFR text at ecfr.gov.
§ 241.545 Covenant against liens.
The security instrument shall contain a covenant against the creation by the borrower of additional liens against the property superior or inferior to the lien of such instrument, except with the prior approval of the Commissioner.
Title 24 published on 2015-04-01
The following are ALL rules, proposed rules, and notices (chronologically) published in the Federal Register relating to 24 CFR Part 241 after this date.


text:
Holistic Doctors
Insomnia is a problem that many of us face on a daily, or rather nightly basis. Temporary solutions like sleep masks, ear plugs, and white noise machines can help sometimes, but don't create lasting change. Dr. Andrew Weil, a Harvard trained medical doctor with a focus on holistic health, believes getting the best sleep ever…


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Free personalized radio that
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Here's how RW members rated this race in the past (40 votes).
In full: Glorious sunshine (perhaps a little too much of it…? …it was 28C later in the day – it's October!!) and a trail that takes you around fields and through glorious woodland. It had been dry before the event so I guess that made a difference.. The course was genuinely stunning. And the organisation exemplary from the outset.People to park you… a volunteer anywhere there could have been a decision on the course... Everybody friendly... A free bottle of beer at the end... Thirty spot prizes… Tea and cakes…A real "community" putting on an event – fantastic job, Oxted Runners! Just how a race should be. So I will definitely be back.Take note though – for a pounder of the streets around London, it did have ups (yikes!) and downs (fantastic!). The hills added about 3-4 minutes onto my typical 10k time, so no chance for a PB if you do a lot of running, but I still managed to come 9th… A definite return next year is on the cards!Date of review: October 3, 2011
In short: Hot, hilly but heaps of fun.In full: Well organised by a small club. Plentiful marshalls, all of whom were very encouraging, lovely scenery, killer uphill drag in the first half but great downhills later... I'm coming back despite the grazed knees.Date of review: October 2, 2011
In short: Perfect race in every wayIn full: What a great race organised by a relatively small club. Puts many other races to shame.Marshalls were everywhere and very supportive.Medal,bottle of beer and tea and cake back at race HQ.Glorious weather made it, might be a tad trickier if it was wet and muddy.Date of review: October 2, 2011
In short: Lovely well organised raceDate of review: October 2, 2011
In short: Lovely Trail Race, Friendly Marshals and a Beer at the Finish! Smashing!!Date of review: October 2, 2011
In short: Superb - thank you Oxted Runners!!In full: Great event - well organised, excellent marshalls, lovely scenery. The heavy rain the night before made the course extra muddy, so even more fun! Tea and cakes at the school afterwards were very welcome too :)Date of review: October 5, 2010
In short: loved it ! without a doubt a must for next year...In full: a lovely trail route , i was ready for the mud but not the hills ! a great mix of runners but most of all some great race organisation from the marshalls , the car parking , the finish , the excellent medal and goody bag + a bottle of beer. i can see why the race limit had been reached days before. will be back again next year.Date of review: October 3, 2010
In short: Very organises race and very friendly club.In full: You can tell the club worked very hard to organise a great off road race and it paid off, we had a very nice day out.Date of review: October 29, 2009
In full: Great race for the trail runners and cross country buffs.If you are new to off roading give this a go it is challaging but being a 10k you can do it.Oxted runners did a great job with all aspects of the race and pulled of a blinder for a first race; well done and good luck next year.Date of review: October 12, 2009
In short: Lovely scenery, challenging course, excellent organisation especially for a first time race, look forward to coming back in 2010.Date of review: October 12, 2009
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Do you need to refresh your academic skills to improve your educational and/or career opportunities? SkillTrain is the Adult Education program with Owensboro Community and Technical College and is here to help!
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Ripoff Report | Complaints Reviews Scams Lawsuits Frauds Reported
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wheels and tires
8 Answers
I've seen 215-40-R18 on a 98 civic but i was told on my 99 it will rub any above 205-40-R17
i have a 96 on stock suspension and im running 17's with 205/40/r17 and have no problems at all....either way i wouldnt go bigger than 16 cuz i think y 17's look too big =/
yes they look big but u have a better tire selection on the 17s
i have 16's on mine (they came with when we bought the car) so they are not a tire or rim that is actually mad for the car so anytime i put weight in the back they rub like fu**er as long as you get 16'2 that are made for a civic youll be fine
keep in mind...the tire & wheel size according to specs are the tires & wheels that are supposed to be with the car for life. if not...ul wind up having suspension problems...handling problems...braking problems...etc. only way to veer from that keeping bigger tires & wheels is the entire suspension has to be redone. just like a truck. if u give a truck a truck lift with bigger wheels & tires...u dont wanna keep the stock suspension...u have to upgrade.
Don't go bigger than 17's. 18s are too big for civics
"205 55/16" is the tire size your supposed to have.
.........thats if u have the model from 06 - 11. the older hondas have a bit bigger size. all yah have to do is google in the "yr/make/model tire size" & bam. if u up in size...your gonna have serious issues as i listed above. depending on the size of the tires upsize...also that has to go up in size are the rotors & brake pads. you'd be stupid to F_ _ _ up your honda by upsizing unless u wanna dump alot more $ into the major under-carriage including shocks struts. ul most likely have to give the civic a body lift so it doesnt rub on the wheel well or when u turn your gonna cause extensive damage to the car.
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text: 'Today' show through the years Caption / Share Matt Lauer, dressed as the iconic androgynous character Pat, left, Savannah Guthrie, dressed in "mom jeans" and Natalie Morales dressed as the iconic character Mary Katherine Gallagher from "Saturday Night Live" appear during a Halloween episode of NBC's "Today" show on Friday, Oct. 31, 2014, in New York. (Credit: AP / Charles Sykes) 1 of 39 0 SHARES http://www.amny.com/today-show-through-the-years-1.202904 "Today" show photos of hosts and guests. http://cdn.newsday.com/polopoly_fs/1.10925883.1444075092!/httpImage/image.JPG_gen/derivatives/display_600/image.JPG Home 'Today' show through the years Newsday 3:59 PM October 5, 2015 "Today" show photos of hosts and guests. More like this NBC's 10 greatest shows of all time TV shows that made an impact TV's 75 most memorable casts Comments


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Check in from 14h / Check out prior to 12h
Green Tree Inn Yangzhou Plaza Hotel: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Yangzhou, China.
Located in Yangzhou, the hotel is a short drive from Slender West Lake and the Yangzhou Museum. It also offers luggage storage, a 24-hour reception and meeting rooms.
Hotel description
This 3-star hotel provides internet, room service and laundry facilities. It also features a dry cleaning service, a safe and a designated smoking area.
Equipped to ensure a comfortable stay, rooms at Green Tree Inn Yangzhou Plaza Hotel have internet access, slippers and bottled water. They provide their very own bathroom where guests can relax in a bathtub.
Each morning, guests can wake up to breakfast provided by Green Tree Inn Yangzhou Plaza Hotel before setting out to see what the surrounding region has to offer. There is also the added convenience of an in-house restaurant.
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Sunday Soul Afternooner - Derby
Duke Of York Burton Road Derby DE1 1TG GB
Sunday Soul Afternooner Details
Sunday Soul Afternooner @ The Duke of York - 7 Burton Road, Derby DE1 1TG
Starts Sunday July 10th 3pm-8pm (every other Sunday)
Free Entrance with resident soul DJ Mickey Walker and guest DJs at every event
This events guest DJs: Taz Birks and Carl Molloy
Playing Northern Soul, Modern Soul, 60s, 70s, 80s chart soul classics
Venue Map
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