text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 10, 1981
|Filing date
|Mar 9, 1978
|Priority date
|Mar 15, 1977
|Also published as
|Publication number
|Pierluigi Renzi, Vittorio Baroncelli
|Original Assignee
|Snamprogetti S.P.A.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (3), Non-Patent Citations (2), Classifications (15)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to a novel composition which permits to carry into effect a diagnostic method for the determination of tri-iodo thyronine, said composition being constituted by an enzyme covalently bonded to the substance in question. The invention also relates to the diagnostic method as such.
It is known that there are a number of methods for the analysis of the tri-iodo thyronine, T3 for short, and of its antibody, especially for their quantitative determination in blood serum.
Among these methods, the following may be mentioned:
(a) Dosing by means of saturation analyses, which provide for the separation of the T3 from thyroxine (T4), such separation being actually cumbersome and being a serious hindrance to a routinely use.
(b) Radio-immunologic assay: at present, it is the most suitable method for the evaluation of tri-iodo thyronine. It provides for the use of a specific antibody and of T3, the latter being labeled with I125. The T3 of the serum being assayed enters competition with the labeled-antibody T3 : the quantity of the complex I125 -T3 is inversely proportional to the concentration of T3 of the sample which is being tested. It should be emphasized, in connection with this method, that the compounds which are required, such as I125, have a comparatively short life and that the test requires an expensive implementation. Furthermore, the use of radio-isotopes is subjected to a severe legislation by the Public Health Authority.
(a) Estimate of the free-hormone fraction by dialysis at the equilibrium, ultrafiltration,
(b) estimate of the relative saturation of the thyroxine-binding sites: uptake by a resin of the labeled T3 (RT3 U, i.e. Resin T3 Uptake),
(c) quantitative evaluation of the thyroxine-binding proteins: concentration of the TBG (thyroxine-binding globulin) and of the TBPA (thyroxine-binding prealbumin).
All these are laborious methods which are based on the binding ability of the TBP to the hormone, and give an indirect measure of the circulating T3. The method which measures the uptake of the labeled T3 by the resin is, summing up, the handiest of the three, even though it has the shortcomings already indicated at 1b, above.
By measuring the concentration of the total T3 and of the interaction between the hormone and TBP, it is possible to calculate the concentration of the free T3.
We have now found, and this is the subject-matter of the present invention, a method for the determination of tri-iodo thyronine which permits to dose it even in extremely small amounts, in the order of the nano-gram and under, without any of the shortcomings pointed out above, said method involving the use of an insolubilized antibody which is specific for T3, and of a composition, which is also within the scope of the present invention, as supplied by a particular enzyme which is covalently bonded to same T3 (sensibilized E-T3 enzyme).
Insolubilization, as is known, permits to obtain immuno-absorbing antibodies which possess a high immunologic specificity and affinity. Using the composition indicated above, these properties are enhanced and, above all, the system acquires quite particular a stability, which is such as to permit to arrive at results which were wholly unpredictable in the light of the conventional knowledge: tri-iodo thyronine can be determined even if it is present in extremely tiny amounts and the reproducibility of the method is very high. This fact is the more note-worthy in that it is widely known that tri-iodo thyronine is an inhibitor of the enzymic activity of a few enzymes, such as lysozyme, with which it also forms an insoluble complex.
The selection of the enzyme of the immunoenzymic assay must be carried out according to the following criteria:
(a) The enzyme must possess a high specific activity at such a pH as not to loosen the antigen-antibody bond.
(b) The enzyme must be such as to be measured easily.
(c) The enzyme must be readily obtainable in a highly purified, soluble and stable form.
(d) The enzyme must possess reactive groups to which other molecules can be bonded without any loss of biological activity.
(e) The enzyme must not be inhibited by substances which are present in the blood-serum.
The determination, according to the method of this invention, is carried into constructive practice by extracting the T3 of the sample being assayed with an affinity chromatography run on an insolubilized anti-T3 antibody, the chromatography being carried out either in a column or in a test tube. By such a step a concentration of the substance being assayed is obtained and components which could possibly interfere with the analysis are removed. Subsequently, the column is treated with the solution of E-T3 and the residual enzymic activity is determined in the effluent. If the sample does not contain substances to be dosed (T3), the antibody blocks the sensibilized enzyme (E-T3) and inhibits the activity of same. If, conversely, the substance is present, it will compete with the enzyme for the antibody, permitting that at least a part of the molecules of the latter may remain active.
From the foregoing, it appears that the immunoenzymic method of this invention for the determination of the tri-iodo thyronine is valid since it gives a direct measure of the circulating hormone, even if the latter is present at extremely low concentrations: such method, in addition, does not undergo any interference from substances which are present in the blood-serum, and can easily be performed.
It is apparent that our method can be employed for the determination of the anti-T3 antibodies, inasmuch as it is sufficient to insolubilize the T3, thereafter putting into contact with the insolubilized T3, first the sample, and, then an enzyme which is covelently bonded to the anti-T3. Lastly, the residual enzymic activity is measured: if the sample does not contain the antibodies, an E-Ab.T3 complex will be the result, and the enzymic activity cannot be determined. If, conversely, antibodies are present in the sample, these will form a T3.Ab complex and it will be possible to determine the activity of the conjugated E-Ab.
The carbonic anhydrase and the bovine seroalbumin were products of the Bohringer-Mannheim Co. The 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide was a product of Sigma. The 3,5,3'-triiodothyronine and the glutaraldehyde have been supplied by Fluka.
50 milligrams (mg) of BSA (bovine seroalbumin) have been dissolved in 25 mls of water and 150 milligrams (mg) of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide have been added thereto. Subsequently, there have been added, dropwise, 100 mg of T3, dissolved in 5 mls of N,N-dimethylformamide. After about 5 mins. there have been added 50 mg of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
The reaction has been allowed to proceed for 18 hours at room temperature, in the dark and with stirring. On completion of the reaction, the sample has been centrifuged and dialyzed against frequent renewals of distilled water for 72 hours. The number of residues of T3 incorporated in each molecule of albumin was determined spectrophotometrically by using a coefficient of 6,100 M-1 cm-1 at 320 nm (nanometer). The results show that about 5 residues of T3 were conjugated with each molecule of BSA. The UV-spectra of BSA and of the T3 -BSA conjugate are reported in the plots 1 and 2, respectively, of FIG. 1 of the accompanying drawing. The antibody has been obtained by sequential immunizations of rabbits with the T3 -BSA conjugate. To titrate the antibodies, the passive agglutination method has been used: this is a classic method of serology and consists in coating red blood cells, previously treated with tannic acid, with the antigen being assayed and then effecting an agglutination assay.
The antibody which has been obtained had a rating of 1:8,000. The purification of the antibody is carried out by centrifuging the serum and diluting the supernatant liquor with one volume of water and one volume of a saturated solution of ammonium sulfate, so as to obtain a final concentration of 33%. After 15 mins., the mixture has been centrifuged at 4,000 rpm for 20 mins. and the precipitate reslurried in a saline solution and precipitated again with ammonium sulfate until a complete decoloration of the solution had been obtained. The precipitate, taken up with a saline solution, has been dialyzed against two renewals (or thread of the saline solution at 4� C. until ammonium sulfate has completely been discharged.
The Bio-Gel P-300 was allowed to become hydrated for 24 hours in water and washed many times in the same medium. To 100 mls of the hydrated gel there were added 500 mls of a 6% solution of glutaraldehyde in a 0.1 M phosphate buffer at a pH of 7.0. The solution was incubated overnight at 37� C. The gel was then washed 10-20 times with water, using a 500-ml volume for each washing operation.
10 mls of activated gel were admixed with 12 mls of blood-serum. The solution was slowly stirred at room temperature for 14 hrs., centrifuged at 3,000 rpm for 10 mins., at 4� C. and the supernatant liquor removed to evaluate the quantity of antibody which had not been absorbed. The particles of the gel were then washed with an isotonic buffer until the optical density of the supernatant liquor was less than 0.02 at 280 nm. The quantity of antibody which had been conjugated was 23 mg per ml of gel.
50 mg of carbonic anhydrase have been dissolved in 25 mls of water and admixed with 30 mg of 1-ethyl-3-(3-dimethylaminopropyl carbodiimide, 20 mg of T3, dissolved in 5 mls of N,N-dimethylformamide have been added dropwise, the pH being maintained between 5.5 and 6.0. The solution was kept with constant stirring at room temperature, in the dark, for about 18 hrs. On completion of this step, the sample was centrifuged and dialyzed against frequent renewals of water at 4� C. for about 48 hrs. The spectrophotometric analysis showed than a residue of T3 had been conjugated with one molecule of carbonic anhydrase. The residual enzymic activity of the conjugate was correspondent to about 50% of that of the native enzyme. The T3 -BCA conjugated was homogeneous and different from the native enzyme as it was checked by electrophoresis.
A calibration curve is plotted, at the outset, according to the following procedure: 1 ml of antibody insolubilized on Bio-Gel P-300 is placed on a column (0.5 by 5.0 cm), thermostatically kept at 25� C. Through the column 1 ml of a solution containing the T3 -BCA conjugate at a concentration of 0.5 M is caused to run. The column is allowed to stand for one hour, then it is washed with 1 ml of isotonic solution and, on the effluent, the residual biological activity of the conjugate is determined. The biological activity of the T3 -BCA conjugate is determined spectrophotometrically at 25� C. by measuring the increase of the absorption of 348 nm due to the hydrolysis induced by p.nitrophenyl acetate. 1 ml of the effluent is admixed with 1 ml of 3 millimolar (mM) p.nitrophenylacetate solution, 0.3 ml of 20mM phosphate buffer (pH 7.4), and 0.7 ml water. In the standard cell a blank is placed which contains all the reagents, the enzyme being excepted. For the determination of tri-iodo thyronine, gradually increased quantities of free hormone (from 3 to 70 nanograms per milliliter) are placed in various columns which contain, each, 1 ml of insolubilized antibody, the test vessels being allowed to stand for one hour. The resin is washed with 5 mls of isotonic solution (buffer), eluted again with 1 ml of 0.5 micromolar T3 -BCA and allowed to stand for one hour. The resin is washed again with 1 ml of isotonic buffer and, on the effluent, the specific activity of the T3 -BCA conjugate is determined. FIG. 2 of the accompanying drawings reports the trend of the specific activity of the T3 -BCA conjugate as a function of the concentration of free T3 (abscissae). The minimum quantity which can be measured is 1 to 2 nanograms.
With the procedure set forth above, there have been analyzed three standard sera of hypo-, eu- and hyperthyroidal patients, the following values having been obtained, respectively: 110 nanograms per 100 mls-236 nanograms per 100 mls-500 nanograms per 100 mls. These values are in good agreement with those measured by utilizing radio-immunological assays. The specificity of the antibody as obtained by this invention has been evaluated by measuring the ability of the T4 in competing with T3 for the antiserum. To obtain a variation of the specific activity of the T3 -BCA conjugate which was equivalent to that induced by 2 nanograms of T3, 500 micrograms of T4 are required. On considering that the normal concentration of T4 in the human blood serum is about 80 nanograms per milliliter its interference in the measuring system is negligible.
FIG. 1 is a UV spectrum of the serum albumin (bovine) and the T3 -bovine serum albumin conjugate in aqueous solution. Plot 1 is the plot for bovine serum albumin alone. Plot 2 is that for the T3 -bovine serum albumin conjugate. Plot 3 is the differential spectrum of the conjugate less the bovine serum albumin.
FIG. 2 shows the percentage variation of the activity of the conjugate T3 -carbonic anhydrase as a function of the concentration of free T3. The curve (a) is for the range from 0 to 7 nanograms per milliliter and the curve (b) is for the range from 0 to 70 nanograms per milliliter. The activity was determined as set forth hereinabove.
|Cited Patent
|Filing date
|Publication date
|Nov 6, 1972
|Jun 18, 1974
|Syva Corp
|Enzyme amplification assay
|Oct 29, 1971
|Nov 26, 1974
|Akzona Inc
|Process for the demonstration and determination of low molecular compounds and of proteins capable of binding these compounds specifically
|Dec 29, 1975
|Aug 9, 1977
|Syva Company
|Iodothyronine enzyme conjugates
|Barman, Enzyme Handbook, vol. II, Springer-Verlag New York, Inc., New York, (1969) pp. 762-763.
|Wisdom, "Enzyme-Immunoassay," Clin. Chem., vol. 22, No. 8, (1976), pp. 1243-1255.
|U.S. Classification
|435/7.93, 435/7.92, 435/188, 435/7.95
|International Classification
|Cooperative Classification
|European Classification


text:
Hi all,
I'm desperate to find a great travel press. I've gone through a Bodum travel press to much dismay, with it not being able to screw on properly after a while and the press letting too many particles through the sides (at least for me).
Does anyone personally have any experience with a good travel press?
p.s. I took a look at the tiger teas one.

subset: commoncrawl


text:
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This review is from: Heavy Rain: Director's Cut PlayStation 3
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Pros: Game looks sick, can't wait to play such a well made game.
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text:
Infection Zone level 9 tips
- App name: Infection Zone
- Developer: TopGameFree
- Genre: Board
- Release: Nov 4, 2010
If you are stuck on Infection Zone level 9 you came to the right place. Below you will find a video walkthrough and some written tips that will guide you through that level. Have fun and enjoy this great game.
level 9 Walkthrough
This page contains Infection Zone video walkthroughs for iOS (iPhone/iPad) called "iphone game - walkthrough - episode 2 -" and has been uploaded on MOBiDIVIPHONE official channel at Feb 29, 2012.
Still need help with this level? Here you can ask questions and discuss with other Infection Zone users.
Hit like if this helped you!
Stuck on some levels in Infection Zone? This walkthrough can help you finish the game.


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Topic: Rush Limbaugh
Advertisers Move to Drop Radio Host
20 reported to have pulled the promo plug as Rush Limbaugh's scandal persists
By Melissa Hoffmann on Mar. 6, 2012 - 3:39 PM EST
More than 20 advertisers have now reportedly run from Rush Limbaugh after his apology to Georgetown student Sandra Fluke failed to quell the media firestorm that was sparked by the…
Conservative Groups Paying Up for Talk Show Endorsements
Politico investigates the business of subtle promotions
By Emma Bazilian on Jun. 15, 2011 - 11:59 AM EDT
For the past few years, conservative radio hosts like Glenn Beck, Rush Limbaugh, Sean Hannity, and Mark Levin have been preaching the messages of prominent conservative advocacy groups—and encouraging their…
Ratings Drop for Limbaugh, Hannity Radio Shows
Numbers have been down since the 2010 elections
By Emma Bazilian on May. 24, 2011 - 12:14 PM EDT
The popularity of right-wing radio shows—including Rush Limbaugh's and Sean Hannity's afternoon programs—has declined steeply in recent months, according to a new report from Arbitron. Limbaugh's and Hannity's WABC shows have…


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Thesis Whisperer Blackline Master Series
A blackline master ia an A4 sheet with exercises or information designed for use in classrooms. The Thesis Whisperer blackline masters series are materials I use in my workshops with research students. These blackline masters are free to use under creative commons share a-like attribution license. Each blackline master listed below has text, which you can lift for your own purposes, and an attached PDF formatted for easy photocopying.
Useful Resources
- 23 Things (Oxford university engage program site)
- A List of Fallacious Arguments
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- Altmetrics – other ways of measuring research impact
- How to make a cornell note taking template
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- Learning to work (pdf)
- Missed periods and other grammar scares
- Optomising your citations
- Presentation Zen
- Typography with Tex and Latex
- Writing across Boundaries
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- Manchester post graduate careers blog
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- Awful Library Books
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- Journal of Universal Rejection
- Piled Higher and Deeper comic
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If there is a page or service that you think should be included, please email the editor.


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Jill Bergman, economic development coordinator for the Town of Danville, announced the soft launch of www.danvilleinstyle.com, a Web site to help people enjoy shopping in Danville "in style everyday."
Currently the site includes a directory of Danville restaurants, shopping, spas and salons, an event calendar, and a page on things to do. It will soon have expanded search features and pages, including separate expanded pages for individual businesses and completed services pages.
"Over the next few months, the site will continue to evolve into an all-inclusive Web site for Danville business owners," said Bergman.
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2 Chainz was arrested and charged with marijuana and paraphenelia possession last night. He was eventually released, but not before cops took their pic with the celebrity! Check out the story here.
Source: Tmz via The Urban Daily on Hello Beautiful on BPNEXT
Also On 97.9 The Beat:
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Can someone please give me some advice?
those who have helped me will know where i am at with what i am trying to achieve, now yesterday i fell and dislocated my shoulder, i have been instructed not to drive for 2 wks and no weights for 6-8 wks. Only cardio
How is this going to impact on what i am trying to achieve?


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UWT Level Controls Launches E-Commerce Site
Oct 07, 2013
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Atherton resident and open-government advocate Peter Carpenter has made good on his threat to try to force the governing board of the Sequoia Union High School District to rescind its appointment of Assistant Superintendent James Lianides to succeed Superintendent Patrick Gemma, who announced plans to retire in June.
Mr. Chadwick cites cases from the 1980s to support a claim that the state's open-government law, the Brown Act, allows legislative bodies to discuss individuals in closed session but not matters of process.
Attorneys for the Sequoia district have said that the district's actions were legal.
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Rated 3.5 out of 5 by 4 reviewers.
Rated 5 out of 5 by hellodoll Greatest conditioner This is one of the best conditioner, I have purchase. 10 out of 10 great. 11 February 2015
Rated 1 out of 5 by AClarky Not great. Contrary to the description "leaving the hair beautifully conditioned", my hair did not feel conditioned, in fact it felt more like straw. Very disappointed. 17 March 2014
Rated 4 out of 5 by Janouk Overall a good product This leaves my hair feeling soft, my scalp feels a little dry, but because my scalp is extremely sensitive it is not a criticism as such, I shall continue using the conditioner as I really like the softness it gives to my hair. 16 February 2013
Rated 4 out of 5 by EmmaS Leaves hair feeling soft and shiny! I used this in combination with the Royal Jelly shampoo. Although all the Dr Organic range are slightly more than ordinary shampoos and conditioners, they leave my scalp and hair feeling clean and free of the chemicals which affect me badly otherwise. This conditioner leaves the hair soft and shiny, and with the shampoo, smells lovely. 01 November 2012
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Trademark: 'T TNG'
On 14. 5. 2002 the community trademark application no. 002696987 was filed for T TNG (Figurative mark) by Theo Henkelman Schoenen B.V. before the OAMI.The goods and services in respect of which registration of the trademark was sought are in class 25. The current status of the trademark is application withdrawn.
Status is 'Application withdrawn'
The Community Trade Mark application has been withdrawn by the applicant for whatever reason. So right now there is no protection of this very trademark ad you can file it.
|14. 5. 2002
|Nice classes
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Despite the fact that the Affordable Care Act eliminated much of the expense for breast, cervical and colorectal screenings for cancer, the Center for Disease Control(CDC) reports the number of adults undergoing the screening in the U.S. has not increased. The data was collected by the CDC using the National Health Interview Survey(NHIS) where 61.5% of adults responded. (This survey is done annually). According to those surveyed, women were more likely to go for a mammogram than a pap smear or colonoscopy. Those without health insurance or without a regular Healthcare Provider were more likely to skip the recommended cancer screenings. These individuals who skipped the screenings were also more likely to have an advanced form of cancer when they did decide to seek medical care.
Representatives from the American Cancer Society and the U.S. Preventive Services Task Force(USPSTF) recently met and updated cancer screening recommendations this year. Healthy People 2020 is a government program based on the most recent guidelines formulated by these two groups for early detection and prevention of cancer in both men and women.
Here is a summary and explanation of their current recommendations:
-Breast self-awareness should be taught in the teenage years and may be used to detect cancer.
-Annual breast cancer screening is determined by a patient's risk, personal and family history. This usually begins at the age of 40. Breast cancer is the most common cancer in women and affects 1 in every 8 women. It can also be found in men. There are hereditary breast and ovarian cancer syndromes that run in families that are linked to mutations in two genes called BRCA1 and BRCA2. Inheriting one of these mutations increases the risk of getting breast, ovarian and other types of cancer. Individuals who screen positive for this mutation will need to have annual mammograms and breast MRI's starting in their 20's based on the youngest person to have breast cancer in the family. These patients should also be offered an annual pelvic ultrasound and a CA 1-25 blood test.( This is a substance made by the ovarian cancer cells.)
-Health care providers should discuss breast cancer screening with all patients. High risk patients should have a mammogram every year. For average risk women between the ages of 50-74, it may be appropriate to have a mammogram every two years.
-Pap smears with co-testing for the HPV virus that causes cervical cancer should begin at the age of 21. The frequency of follow up pap smears will be determined by these results. If a woman has never had an abnormal pap smear and has been negative for the HPV virus, this screening may stop at the age of 65. If a woman has had her cervix removed with a hysterectomy for benign reasons, this screening can stop after the hysterectomy. If a woman still has her ovaries after the hysterectomy, however, a yearly pelvic exam is needed. A vaccine to prevent HPV induced cancers is available to both men and women and is given between the ages of 9-26. The long term efficacy of this vaccine in prevention of cancer has not yet been established.
-Endometrial cancer is the most common pelvic cancer in women. Any woman with abnormal uterine bleeding should be offered a pelvic ultrasound and an endometrial biopsy if indicated. This cancer usually occurs in women over the age of 50, but may occur in younger women who have chronic hormone imbalance due to obesity, polycystic ovaries, taking estrogen without taking progesterone, and taking Tamoxifen to prevent recurrence of breast cancer. Screening may start earlier in individuals with "Lynch Syndrome", an inherited disorder that presents with polyps in the colon that can turn to colon cancer at a young age. Women with this disorder are more susceptible to developing endometrial and other cancers. These women may be offered screening with pelvic ultrasound and endometrial biopsy by the age of 35.
-Testing stool for blood should be done every year and when to start in the adult years will depend on the patient's personal and family history. This usually starts at 35-40 . For those between the ages of 50-75, colonoscopy is recommended every 10 years or sooner depending on risk, personal and family history.
-The big news in lung cancer prevention is screening and smoking cessation. If you are between the ages of 55 and 80 and have a 30 pack year history of smoking, or quit in the past 15 years, your Provider may recommend a chest x-ray or other testing.( Pack year history is the number of packs of cigarettes smoked per day time the number of years you have smoked).
-Screening for skin cancer and melanoma can be done at your annual exam or by a Dermatologist. Any raised, darkened, irregular or spreading lesions should be evaluated ASAP. The use of sunscreen SPF 15 or higher is recommended to protect the skin.
Ladies and Gentlemen of Richland County, be proactive and don't become a statistic. See a Provider for your annual exam and find out what preventive screens are appropriate for you! The Richland Center Medical Staff is your Home Town Team and we are hear for you!
Janice H. Alexander, RN,MD


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- High quality sound
- Convenient in line controls
- 3.5 mm jack (headphone and mic)
- 40 mm drivers, with noise cancelling microphone
Really Good! 03/16/2014
This review is from: Creative Fatal1ty Gaming Headset
it work's right!, Nice and loud, nice mic sound, comfortable set of head phones and i have owned many!
wish the mic could flip up out of way, but it is what it is, not made that way,, it does work well for what it is designed to do.
Other Thoughts:
my first pair was $60, bucks, got the second at $25, they have been out for about 7 or 8 years, now.
1 people found this review helpful. Did you? Yes / No Thanks for the valuable feedback you provided!


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Medical marijuana laws in Illinois are changing. Governor Pat Quinn has signed into law a bill that allows kids with epilepsy to use marijuana to ease their symptoms. Quinn says the new law will alleviate the pain and suffering of many adults and children across the state.
The law takes effect in January and would allow children who suffer from seizures to be treated with non-smokable forms of cannabis, as long as they have permission from a parent.
(Copyright WBGZ Radio / www.AltonDailyNews.com)
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Navy EVAL Bullet Examples
Led 35 Sailors in the completion of 1,066 maintenance actions, encompassing over 18,200 man-hours. His diligent management yielded the qualification of 11 technicians and six Collateral Duty Inspectors, increasing 62A's productivity by 35%.
Chosen by his peers to serve as SCPOA President. He organized and directed 12 fundraising events in support of the Command Christmas Party and donation of 457 gifts for students at Cedar Hills Elementary School, while coordinating 18 Highway Clean-up events with a combined total of 270 hours devoted to the Jacksonville Community.
Avid participant in all CPO 365 Phase I and II evolutions, instilling Navy tradition and Core Values in 21 First Class Petty Officers.
-He leads by example and his peers gravitate to him for advice and guidance. He provided invaluable training to junior technicians. Assisting in qualifying five RADAR System Supervisors and three Damage Control Petty Officers greatly increasing divisional effectiveness, and watch bill flexibility.
-COMMAND-WIDE IMPACT. As FCPOA President, he rallied 25 FCPOs in 26 events, raising over $2K for the Command and the Children's Holiday Party. Chaired three SOQ, one SOY and eight EAWS boards.
- PERSISTENT OPERATOR. Maintained operator qualifications for both Shop X and Shop Y JQRs. Provided 381 time-sensitive reports for indications and warning to forward deployed US Naval vessels forward deployed.
Skilled technician with unlimited potential.
Excels as a leader and manager. Her ingenuity contributes to enhanced Sailorization and command success.
Petty Officer Doe is a top notch sailor, HSB Tra-Sup and leader who constantly demonstrates exceptional initiative and the desire to succeed in any task which he is involved.
Boundless potential and ability, displays the determination and knowledge to cultivate his subordinates
TOP PERFORMER! Ranked 1 of 8 Second Classes. Possesses leadership, creative ability, and self confidence to excel at any task needing to be completed. High morale, initiative, accuracy and capability highlight his daily performance. Specific accomplishments are:
- Superb supervisor. Supervised the production efforts of eight Sailors in collaboration with depot level artisans and performed 129 Quality Assurance inspections. Efforts resulted in repair of 41 Electro-Optical Sensor Units, a $15.5M cost avoidance, and zero items returned for rework.
- Knowledgeable technician. Completed 36 maintenance actions, contributing to a 96 percent repair rate while deployed onboard USS GEORGE H W BUSH (CVN 77).
Solid technician with potential to excel in a leadership role.
As a member of the Engineer team, he passed down what he learned during his career to junior sailors, ensuring the proper development of the next generation of naval professionals.
- Provided CJTF-HOA J6 with resource documents to assist with their communications training program.
#1 of 2 OUTSTANDING CHIEF PETTY OFFICERS DESPITE SHORT TIME ONBOARD ... AN IMPACT TEAM PLAYER!
SN Sailor has stepped into the Patrol Division and quickly became an intergral part of his duty section. Always willing to help and learn, he sets a great example for others to follow.
Petty Officer Knight is an enthusiastic petty officer with a positive attitude and willingness to accept any assignment.
Petty Officer Svedin, in his short time here at VFA-2, has proven to be a fast learner in the duties and responsibilities as Assistant Security Manager. He is a motivated performer who shows promise and potential.
Enthusiastic and dedicated, actively seeks out challenges and doggedly pursues them until resolved. He is singled out for jobs that require determination and skill and has improved or corrected many chronic problem areas. He is a shining example to his peers and subordinates.
- Made maximum use of pre-operational phase by acquiring new qualifications: completed the Senior Enlisted Propulsion Engineering Course (SEPEC), Fuel Testing, RODP, Fire fighting, and ADAMS for Supervisors.
- Performed flawlessly during NEPTUNE WARRIOR training course--increased interoperability among NATO coalition forces, facilitated flow of intel between allied ships and fleet.
- Organized Junior Sailor, Professional Military Knowledge training for 6 Sailors for the September US NAVY Advancement Exam.
-Effective manager- Impressive technical publications librarian, directly contributed to the workcenter receiving grades of outstanding on recent workcenter quarterly audits through meticulous attention to detail, improving quality of training and maintenance.
-Deckplate leadership produced the most professional mixed-gender working environment I've ever seen; zero sexual harrassment issues!
-Proven leader. Successfully assumed the role of Airframes workcenter supervisor during the month of December. Directly responsible for a 100% sortie completion rate during TSTA III, resulting in the carrier qualification of 16 aircrew and maintaining 14 fully mission capable aircraft.
- Dedicated and invested in our Navy, he demands involvement. He volunteered for a difficult but successful nine-month IA. He was certified early as CTF67 Task Force Watch Supervisor and has made impressive progress in his graduate studies.
- Actively embraces leadership role and serves on Standards of Conduct review boards ensuring adherance to standards and promoting positive command climate.
-Poised for achievement. Aggressively pursed and completed all requirements for the navy's national apprenticeship program. Awarded national journeyman license and Commonwealth of Virginia certificate of completion and state journeyman license.
- Personally responsible for managing $5.3 Million dollars in squadron owned Individual Material Readiness List (IMRL) equipment.
- Invested in success! Turned down Recruiting duty assignment and navy advancement to remain in place and continue instruction.
-Fostered an atmosphere of understanding, trust, and tolerance; increased team effort shattered all records!
- As BEQ Liaison, his superb, sound and reasoned leadership brought the barracks within MED IG standards. Obtained approval of over $400k for upgrades, which dramatically improved residents' quality of life.
- STANDOUT MENTOR! An active, dedicated CMEO, led by example and encouraged equal treatment of and opportunity for all Navy members. Climate assessment results demonstrated improved morale and increased understanding of and support for Navy policies.
-A respected leader, sets and expects stringent, yet achievable, performance standards for subordinates.
Leadership. Facilitates communication up and own the chain of command by being open and candid when asked questions or expressing his opinions.
CPO Pozzi is an enthusiastic, dedicated CPO. She has quickly transitioned from a maintenance background to her new staff duties
-Superb Leader. Selected over more Senior Petty Officers to supervise two Avionic workcenters, he quickly established himself as an outstanding manager and administrator.
-Actively leads Apprentice Technical Training students in physical development and trains to excel in skills training tasks.
-Singlehandedly organized the conversion to the Hazardous Material minimization program, significantly reducing squadron hazardous material/waste by 35%.
Superior leadership ability and command involvement earned him my top ranking. Number 1 of 6 outstanding Senior Chiefs. A natural leader. Hand picked over 14 other command E-7 and above personnel to fill short-fused OIC billet in Pearl Harbor Naval Station, Hawaii.
-INDUSTRIOUS. The driving force in workcenter production. He consistently tackles the most complex discrepancies. He personally troubleshot and repaired aircraft 500's Automatic Carrier Landing System which had been inoperative for 15 months. Dedicated numerous over-time hours in rebuilding a hard to access aircraft disconnect and display connector.
-Led workcenter to highest PRT average in the unit. Raised workcenter average by 40%!
-Revised the entire squadron tool control program, increasing accountability of tools to 100%.
A leader with an indefatigable work ethic. Hand picked to be the only E-7 to attain the title of Senior Watch Officer which is usually held by an E-8. He makes the process of managing the Ops Center look easy.
-Exceptional CPO; superb military image made him the obvious selection for NCOIC of the unit Honor Guard
-Total team player. Intimately involved in the planning and execution of numerous successful fund raising projects for the first class association.
-Helped renovate the USS Constitution CPO living spaces for the CPO Selectee Legacy Academy
Role Model. Positively impacted Command by establishing professional and productive work climate and successfully completing all Pre-commissioning Unit Instructions. Thoroughly reviewed ship capacity and services to ensure incoming personnel requirements will be met or exceeded. His in-depth analysis identified overlooked provisioning and improved deployment readiness.
-Instituted new quality control inspection procedures raising customer satisfaction 25%


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Looking for online fabric shops based in the UK? This Very Berry Handmade comprehensive list is the best resource around.
When you're starting out with sewing, it's tricky to find the best fabric places – and there are new shops opening all the time…. so, I've created this directory of online UK based fabric sellers to help you in your search.
**Please bear in mind that this list is always a work in progress and forgive any errors and broken links and incomplete entries. **
My Sponsors
Black Sheep Wools
If you are a knitter, crocheter or stitcher you will already know Black Sheep Wools as a fantastic place to go for yarn, threads, patterns, hooks, needles, cross stitch supplies and more. If you can drag yourself away from all that gorgeous fluff and stitchy goodness, the great news is that they've recently started stocking fabric too, so it's definitely somewhere to bookmark to your list of great fabric shops. They stock fabrics by lots of favourites, including Denyse Schmidt, Nel Whatmore, Tim Holtz and Tina Givens, Kaffe Fassett, Michael Miller and Tula Pink. Postage is a flat rate of just £2.50 with free delivery on orders over £25, which is just excellent value. Speaking of value, they also have regular offers, and lots of things going on (including fantastic workshops at their Craft Barn near Culcheth in Lancashire, and a great café too!).
Black Sheep Wools Blog
Black Sheep Wools on Facebook
Black Sheep Wools on Instagram
Dragonfly Fabrics
Dragonfly Fabrics should be right at the top of your list for online fabric shopping if you are an enthusiastic dressmaker. They have a brilliant range of jersey fabrics, including cotton jersey and Ponte Roma to tempt you. They also stock a great range of cottons, including cotton lawn, chambray and poplin. They also have linen fabrics, lovely stretch velveteen, and a fabulous selection of boiled wool too. A huge strength is an excellent range of sewing patterns (one of the best online in the UK I think). The folks at Dragonfly also have fantastic expertise in dressmaking in their time, and can offer advice on fabric choices – and you can order fabric samples so that you can really be sure that the fabric is right for your project.
Dragonfly Blog
Dragonfly on Facebook
Dragonfly on Instagram
Dragonfly on Pinterest
Duck Egg Threads
Duck Egg Threads is a specialist online fabric shop selling wide range of Liberty Tana Lawn prints (both the classics and the seasonal releases). Tailored to quilters and crafters, who often do not need to buy larger pieces of a premium fabric when only a little is needed, their Liberty Tana Lawn is mainly sold in the very useable size of fat eighths (33cm x 50cm), but you can also buy in fat sixteenths too (33cm x 25cm).
Duck Egg Threads also stocks the Pure Elements line of solids from Art Gallery Fabrics – which work really well with Liberty lawn, as they have a very similar feel. Really usefully, there's also a range of notions that's small, but absolutely perfectly formed if you are interested in hand sewing and/or English Paper piecing – and who isn't when you are sewing with Liberty lawn? So there are Aurifil threads in all the right colours (shades of grey and cream of course!), Black Gold needles, Clover clips, quilting pins, and my favourite Sewline glue pen, amongst other goodies.
Duck Egg Threads on Twitter
Duck Egg Threads on Instagram
My Fabric House
As soon as I spotted My Fabric House, I knew that I had to add it to this list. The reasons? An attractive, well-designed interface, a really good choice of interesting, different, and very pocket-friendly, fabrics, some really fun haberdashery and trims, highlighted with really excellent photography. My Fabric House say "Our aim is to create a fuss-free, secure and delightful environment for you to shop for 'sweet n chic' haberdashery and fabrics at the comfort of your home", and with the amount of work that's been put into this site, they're doing pretty well so far. Pop round and check out the lovely stuff that they have in stock. They have some very tempting subscriptions if you want a regular parcel of goodies delivered to your door.
My Fabric House on Facebook
My Fabric House on Twitter
Cloud Craft
Cloud Craft should absolutely be your first port of call for fantastic quality 100% wool felt for stitching and craft. The range of colours is second to none, and you can buy in a variety of useful sizes – and the price is great oo. But more that that, you will find the most fabulous array of goodies, carefully chosen to bring together the loveliest supplies for modern hand stitching. There's linen, Aida, Zweigart fabrics and all sorts of interesting items for you to stitch onto, along with all the threads, handy tools and notions you could need for contemporary embroidery. There's also a brilliant range of trims, buttons and ribbons to choose from too. Delivery is always super speedy and there's a lovely flat rate delivery charge of £2.75.
Cloud Craft on Facebook
Cloud Craft on Twitter
Cloud Craft on Instagram
Cloud Craft on Pinterest
Prinfab – Print your own fabric
Prinfab offers you the opportunity to get your own designs onto fabric (there are 10 options of fabric, including cotton, cotton percale, poplin, linen and bamboo available) or buy fabric created by other artists/indie designers. It's also a place where you can sell your own fabric designs for commission payments. Think a UK-based version of Spoonflower. The prices for custom printed fabric start at £12.99 per metre, which is very competitive.
Prinfab on Facebook
Prinfab on Twitter
Thanks to all my sponsors for supporting my work here at Very Berry.
Abakhan has a huge stock of patchwork, craft and dressmaking fabrics to choose from. They also have great range of craft supplies, haberdashery and a really good stock of sewing patterns too. Abakhan have bricks and mortar shops in Birkenhead, Chester, Hanley, Liverpool, Manchester, Mostyn, Preston and Bolton.
Abakhan on Facebook
Abakhan on Twitter
Ada and Ina
Ada & Ina have a collection of linen fabrics and cotton fabrics for curtains, upholstery and clothing. This is a beautiful range, and includes Oeko-Tex certified organic linen fabric. You can order a very generous 5 free samples of fabric before you order.
Ada and Ina on Facebook
Ada and Ina on Twitter
Ada and Ina on Instagram
African Fabric Shop
This is a wonderful shop with a lovely range of fabrics that could never be described a run of the mill. There are stunning hand-dyed batiks from Ghana and The Gambia, and, my favourite, a stunning selection of Schwe Schwe fabrics from Coral Tree. One great way to find out about these fabulous fabrics is to buy one of their great range of Adventure Packs. There are also gorgeous beads and some really good bag kits and quilt kits too. Payment is by credit/debit card via Worldpay, and delivery charges are calculated by weight.
African Fabric Shop on Facebook
Dressmaking, upholstery and utility fabrics, and is always worth a look if you are after good value basics. This shop also has an Ebay store.
Ainsberry on Facebook
Ainsberry on Twitter
Backstitch is great for dressmakers and quilters alike, and has a fantastic range of sewing patterns. There's also an excellent selection of haberdashery, notions and quilting supplies. There's a real life Backstitch shop in Burwash, where you can also take part in a wide range of classes (sewing, knitting and crochet).
Backstitch Blog
Backstitch on Facebook
Backstitch on Twitter
Backstitch on Instagram
Blooming Felt
Blooming Felt is a dynamic and well-designed shop that has a fab range of of felt sheets, felt shapes and needle felting supplies. They also have felting craft kits, books, gorgeous embroidered ribbons, a fantastic range of buttons (including shell and ceramic buttons) , and findings for your felt jewellery. There's also a tips and tutorials section. Payment options include Paypal. There's a flat rate delivery charge of £2.25 and orders over £40 are delivered free – there's also a loyalty point scheme, so you can earn points as you spend.
Blooming Felt on Facebook
Blooming Felt Blog
The Bramble Patch
The Bramble Patch online shop has a good range of quilting and patchwork fabrics, plus quilt kits and wadding. They also have a loyalty scheme for regular customers. There is a real life Bramble Patch shop in Northamptonshire where you can attend all sorts of classes in stitching, patchwork, felting and more.
The Bramble Patch on Facebook
The Bramble Patch on Twitter
The Bramble Patch on Instagram
Calico Laine
Calico Laine bills itself as 'the really useful textiles company', and it's a good destination if you're after a pretty good choice of basic dressmaking or craft fabrics plus all the notions, haberdashery & sewing craft supplies that you need. Calico Laine run regular offers and competitons on Facebook and Twitter, so it's worth keeping up with them there. Delivery is £2.95 unless your order is over £30, in which case it's free.
Calico Laine on Facebook
Calico Laine on Twitter
Celtic Fusion Fabrics
I love the eclectic, slightly quirky range at Celtic Fusion Fabrics has an eclectic, slightly quirky, fun and colourful range of fabrics, mostly aimed at quilters, but with some dressmaking fabrics too. One of the stand-out reasons to shop at CFF are the excellent 'cloth stacks' (fabric bundles), including 'smallies', which are lovely selections of smaller cuts of fabric – always really useful when you want to check out a few fabrics, or you're working on a smaller project.
Celtic Fusion Blog
Celtic Fusion on Facebook
Celtic Fusion on Twitter
Celtic Fusion on Instagram
Cheap Fabrics online
Dressmaking fabrics, bridal fabrics, furnishing fabrics and craft fabrics. There's a good range of trims and haberdashery
Cheap Fabrics on Facebook
Cheap Fabrics on Twitter
Clothkits has a really good selection of fabrics, haberdashery, notions, and more, as well as the sewing kits that they are famous for. There are lovely Echino linens, a small but delightful selection of Liberty Prints, some fantastically colourful and summery striped canvas fabrics. I find the Liberty Print bias binding on wooden bobbins almost irresistible (but will have to resist because it isn't cheap..) – fortunately it is available by the metre too, and the ribbon and trim section is a marvel – such a well chosen collection, including lovely bits and bobs from VV Rouleaux. It's also nicely laid out, and seems a very easy to use site, so it's well worth a look – especially if you are interested in getting some funky haberdashery. Payment is by credit/debit card or cheque – there's no Paypal.
The Clothkits Blog
Clothkits on Facebook
Clothkits on Twitter
Coast and Country Crafts
This shop is very definitely about quilting, so in addition to their fabric range (much of which I think of as being in a gentle vintage/folksy style), they also have lots of quilting accessories, quilting books and kits. I particularly like the strong selection of linen fabrics a wide range of colours and prints, which aren't widely available elsewhere.
Coast and Country Crafts and Quilts on Facebook
Cotton and Vintage
Great Ebay shop selling a lovely selection of Zakka and Shabby Chic style fabrics.
Cotton Patch
Cotton Patch has a great range of fabric (including designers such as Kaffe Fasset, Amy Butler, Tilda and more), notions, patchwork and quilting gadgets, sewing machines, and big quilting machinery (long arm quilters, frames etc.), books, patterns, fabric bundles & threads and more. The website can be a bit frustratingly long to navigate, but I guess that is the downside of having such a great stock list. They have discount clubs for regular shoppers. In my experience, delivery can be slow unless you pay for the more expensive Express option.
The Cotton Patch Blog
The Cotton Patch on Facebook
Crafts and Quilts
There's an extensive selection of fabrics at Crafts and Quilts, a family run shop with an real high street presence in Southport. They stock more than 1500 quality quilting fabrics and a huge selection of notions for quilting along with a great range of products for knitting, crochet and needlecrafts of all kinds. You can browse fabrics by style, designer or price (useful!) and there's a search option. Their prices are competitive and payment is by credit or debit card. Postage is calculated by weight of order, and they commit to refunding any overpayment on postage.
Crafts and Quilts Blog
Crafts and Quilts on Facebook
Croft Mill
Croft Mill specialise in dressmaking fabrics, but have craft, quilting and furnishing fabrics available too. There's always something new and interesting in stock, and their quirky website is always well worth a browse. Fabrics can be browsed by type and the quality of their photography helps you to feel confident that you know what you are buying.
Croft Mill Fabric on Facebook
Croft Mill Fabric on Twitter
Cross Patch
A shop for anyone with an enthusiasm for patchwork and/or cross stitch. The shop is not terribly easy to navigate your way around and you have to make your orders via email, which put me in two minds about including Cross Patch in this list, but there is so much lovely treasure here that it's worth persevering.
A lovely range of dressmaking fabrics (and some cottons that would be great for patchwork and other sewing) at good prices. Other than interfacings, Ditto is just about the fabric, so you wont find haberdashery or notions here. Payment is by credit or debit card – and there's a PayPal option too. Delivery charge depends on the weight of the parcel and is calculated at checkout. Ditto has a real life shop in Brighton.
Ditto Fabrics on Facebook
Ditto Fabrics on Twitter
Ditto on Instagram
Donna Flower
Donna Flower stocks antique, vintage and retro fabric and haberdashery. What immediately impresses is the extent of the range, but the shop is divided up into sections by period and theme, so it's pretty straightforward to narrow down what you're looking for. There's also a free text search box so that you can search by colour, design or type of fabric too. It would be easy to lose a few hours (and worse) at Donna Flower.
Donna Flower on Facebook
Donna Flower on Instagram
Dots N Stripes
If you sew clothes for kids then you should take a look at Dots N Stripes. They stock fabrics, patterns and supplies from Farbenmix, Mamu Designs, Ottobre and Studio Tantrum. I love all the gorgeous fabrics – they've got some great fleeces, printed corduroys, stripy jerseys and lovely cottons. They also have fabrics for women's clothes too. You can only browse fabrics, but the interface is very clear. The payment options are credit /debit card (via Paypal), cheque or postal order. Delivery charges to the UK are as follows – small items, £2.80; fabric up to 3 metres, £4.50; fabric over 3 metres, £6.40 and shipping is free on orders over £70.
Dots n Stripes blog
Dots n Stripes on Facebook
Doughty's Online
Doughty's has a great reputation amongst quilters as a source of a good range of fabrics at great prices. They also sell dressmaking fabrics, and a good range of utility fabrics (sheeting, calico) and wadding. They also have lots of other fabrics, yarns, threads and quilting materials like wadding, dying cloth and calico. The website is also very easy to navigate, and it definitely worth signing of their newsletter because there are regular reductions on all kinds of goodies.
Doughty's Blog
Doughty's on Facebook
Doughty's on Twitter
Dragonfly Quilting
Dragonfly Quilting describe themselves as the largest stockist of extra-wide quilt backing fabric in the UK, and I'm not going to argue with them! If you really can't face piecing the backs of your larger quilts, then extra-wide backing fabric is what you need, but many shops only sell an extremely limited range, so Dragonfly Quilting fabric should be your first port of call if you are looking for a really good selection to choose from.
Dragonfly Quilting on Facebook
Dragonfly Quilting on Pinterest
Eclectic Maker
This a great shop with a well thought out design, great stock and a welcoming vibe. Browsing the fabrics, the emphasis is definitely on the sophisticated end of the market, with designers such as Amy Butler, Kaffe Fassett, Tanya Whelan, Anna Maria Horner and Joel Dewberry well represented.
There are lots of buying options – with FQs, yardage, FQ bundles and pre-cuts all available. There are also sewing patterns, a small but useful range of haberdashery and notions, including wadding/batting and Vilene. Finding what you want couldn't be easier – you can browse by designer, colour, theme, collection, and type of fabric, or you can do a keyword search to get directly where you want to go. Delivery prices are on a sliding scale, with a maximum cost of £3.50 – orders over £50 are delivered free of charge. Payment can be made by credit or debit card, or Paypal. It's very hard to find fault here, so pop round and have a look!
Eclectic Maker on Facebook
Eclectic Maker on Twitter
This shop is known for its excellent customer service, fast delivery and good quality fabrics at good value prices. You can't say more than that really. Judging from my brief look round their website they have a pretty vast variety of fabrics available – for dressmaking and other crafts too. They've also got lots of useful haberdashery and patterns.
Elephant in my Handbag
All kinds of fabrics, including a brilliant selection of quilting fabrics and some dressmaking fabrics. There's a good selection of haberdashery too. Well worth a follow on social media too where there are always bargains to grab!
Elephant in my Handbag on Facebook
Elephant in my Handbag on Instagram
Elephant in my Handbag on Twitter
Emma's Fabric Studio
This us a great shop, with lots of fun fabrics from manufacturers Riley Blake Designs, Robert Kaufman and Michael Miller, and all those extras that are so important, such as buttons, wadding, trims and binding. Emma takes particular pride in her stock of fabric bundles (which she says are all named, like Mulberry bags), and I'm not surprised, they look just great.
The quality of the images in the shop are just fantastic (a lesson for us all in pretty product photography!) and in the bundle section, there's a pic of each fabric in the bundle, as well as the bundle itself – which is really going the extra mile for us customers. Emma also places great importance on customer service – and is happy for people to phone to talk about their requirements, colour matches or any specific questions they might have.
Payments are processed with Paypal (or the Paypal credit/debit card facility) and postage is calculated by the weight of your purchase. Here are the other links you need if you want to keep up with shop news:
Emma's Fabric Studio blog
Emma's Fabric Studio on Twitter
Emma's Fabric Studio on Facebook
Empress Mills
Quilting fabrics are available, but Empress Mills also has an excellent range of utility fabrics like calico, Vilene, and also their renowned Egyptian cotton. They are also famed for their amazing range of sewing threads.
The Eternal Maker
I can't speak highly enough of The Eternal Maker – it's run by a hugely enthusiastic team who select the most fabulous fabrics to have in stock. The newly designed website is fabulous to use too. There's a great range of bang on trend fabrics, with lots of gorgeous stuff from Japan. Brilliant – you are definitely going to need their fab Wishlist facility! Postage charges are calculated by weight – up to 2 kilos £2.75; over 2 kilos £5.00, and payment is by credit/debit card via Sagepay.
The Eternal Maker Blog
The Eternal Maker on Facebook
The Fabric Frieze
A long-established Ebay shop (with excellent feedback) which now (2014) has a stand-alone shop. Fabric Frieze stocks an extensive range from fabric studios such as Moda, Robert Kaufman, Riley Blake, Michael Miller, Tilda and Blend. The shop offers free UK delivery on orders over £70, but it is frustrating that it is difficult to find out what the postage costs are for cheaper parcels. You can sign up to be included in a monthly giveaway by registering with their website. The payments options are your PayPal balance, or credit/debit card via PayPal.
The Fabric Frieze on Facebook
The Fabric Frieze on Instagram
Fabric Godmother
Dressmaking fabrics and haberdashery, and a really great range of sewing patterns. They also run sewing classes from their studio in Hove.
Fabric Godmother on Facebook
Fabric Godmother on Twitter
Fabric Godmother on Instagram
Fabric HQ
Good modern range of quilting, dressmaking and upholstery fabrics. There's haberdashery and sewing patterns too.
Fabric HQ on Facebook
Fabric HQ on Twitter
Fabric HQ on Instagram
Fabric Inspirations
I love the range of fabrics here, and there is a great search facility that allows you to search by colour and designer at the same time – an excellent tool. So, excellent shop and excellent searching tools – it's hard to beat. One of the few downsides of this shop is that you mostly have to buy by the 1/2 metre – but the fabrics are so lovely, you almost always want to anyway!
Fabric Inspirations on Facebook
Great (huge even) range of all kinds of fabrics. If you need something a bit out of the ordinary, this is definitely a great first port of call. The prices are great too.
Fabricland on Facebook
Fabricland on Instagram
The Fabric Loft
A good range of modern quilting fabrics.
The Fabric Loft Blog
The Fabric Loft on Facebook
The Fabric Loft on Twitter
Fabric Rehab
Really lovely selection of more unusual contemporary quilting and upholstery fabrics, with the emphasis on retro and funky. There's a small range of haberdashery and sewing patterns too.
Fabric Rehab Blog
Fabric Rehab on Facebook
Fabric Rehab on Twitter
Fabric Rehab on Instagram
Fair Trade Fabric
I love the beautiful colours and weaves of the cottons at Fair Trade Fabric. I am also really pleased to be able to draw your attention to their stance on only selling cotton that provides a fair wage for the people who grow and weave it – you can read more about where their fabrics come from on their site.
Fancy Moon
A really excellent range of quilting, dressmaking and upholstery fabrics. They also have a small range of patterns, haberdashery, and run classes from their shop in London.
Fancy Moon on Twitter
Fancy Moon on Facebook
Fancy Moon on Instagram
Felt Folk
Feltfolk has felt sheets, felt balls & other shapes. They also have some beads, ribbons, books & craft kits. They have lots of lovely buttons and DMC cotton threads.
Felt Folk on Facebook
Felt Folk on Twitter
Felt Folk on Instagram
A lovely shop which sells concentrating on funky fabrics from designers like Michael Miller and Robert Kaufman especially, and with more to come. Frumble also has an excellent haberdashery range, including lovely ribbons, buttons, elastic, trims, tapes and threads.
Frumble on Facebook
Frumble on Twitter
Guthrie & Ghani
Guthrie & Ghani have a great mix of fabrics for dressmakers and quilters alike – the fabrics sold online by the 1/2m (but you can phone if you have specific requirements), and they have a real shop in the Moseley, Birmingham. They also stock knitting yarns, haberdashery, sewing & knitting patterns, purse & bagmaking accessories and more. The online shop could be a little bit more user-friendly, with better search options and more browsability, but their stock is fantastic, and the blog is a great read, so it is well worth paying them a visit.
Guthrie & Ghani on Facebook
Guthrie & Ghani on Twitter
Guthrie & Ghani blog
Hannah's Room
Batik fabric specialists, including Bali Pops and pre-cut Batiks. Hannah's room also has patterns and kits to make the most of your batiks, and a renowned Beautiful Batik subscription club.
Hannah's Room on Facebook
Hannah's Room on Twitter
Hannah's Room on Instagram
Handmade Presents Wool Shop
I've included them in the list because they have a wonderful stock of glorious pure wool felt – which is light years away from some of the sometimes unpleasant and flimsy acrylic stuff that seems to be the norm. I've ordered from here many times and have always had fantastic service – the quality of the felt is brilliant and the colours are gorgeous. It's not cheap, but it's totally wonderful and you can buy it in quite small pieces, which makes it a bit more affordable.
Higgs & Higgs
A really lovely selection of fabrics for quilters, dressmakers and indoor dec projects too. On the quilting side, designers and manufacturers represented include Michael Miller, Dashwood, Riley Blake, Moda and Sevenberry. For dressmakers there's chambray, jersey knits, babycord, fleece and absolutely loads more (this is just skimming the surface). The haberdashery is sadly fairly limited, but there is a lovely range of ribbons and trims. Another stand out section is the fabulous range of coordinating fabric bundles. They have a real life store in Gloucester.
Higgs & Higgs on Facebook
Higgs & Higgs on Twitter
Needs no introduction. A good place to go for sewing supplies such as thread and wadding, and they also have a range of non-designer-brand-name, good value, quilting cottons.
Hollies Haberdashery
A very strong range of quilting fabrics, and some dressmaking fabrics too. Brands stocked include Michael Miller, Riley Blake, P&B Textiles, Red Rooster and lots more. There is a fantastic range of haberdashery and notions including brands such as Hemline, Fiskars and EZ Quilting. There's also a selection of sewing patterns including Burda, New Look and Kwik Sew. The delivery charge is set at £1.95. I can vouch for the excellent customer service because it's my local fabric shop here in Newcastle-under-Lyme – where they run workshops and classes too.
Hollies Haberdashery on Facebook
Hulu Crafts
Hulu Crafts stock great supplies for sewers and knitters. They stock Amy Butler, Kaffe Fassett and good selection of Moda fabrics. What attracted my attention was their good range of Moda bundles. For example they have the lovely Lumiere de Noel collection by French General as a Jelly Roll, Layer Cake and Charm Pack. They also stock Moda's new Candy Bar bundles – containing four packs of 40 – 2.5″ x 5″ fabric rectangles in gorgeous fabrics.
Hulu Crafts Blog
Hulu Crafts on Facebook
Hulu Crafts on Twitter
JB Quilting Fabrics
This is a slightly old fashioned and traditional feeling website (beware of the little jingle if you are doing work-based browsing or if you are easily surprised!), but if you are the type to be put off by that, don't let it. JB Quilting has a huge range of Moda, Timeless Treasures and Benartex fabrics and more. Judging by the quantities listed, Christmas and children's fabrics are a particular speciality. You can browse by colour, by manufacturer and by collection, and there is a full site search facility. I can't quite work out the delivery charges for orders under £25, but over £25 the postage is free. Payment is by Paypal, or by credit/debit card. Their customer service comes highly recommended by my readers. They don't appear to have a social networking presence.
JuBerry Fabrics
Good range of quilting fabrics, and quilting tools, notions and books. I find the site a little cumbersome to use. There is a real life shop near Newbury in Berkshire, where there are regular classes and sewing groups.
Juberry on Facebook
Juberry on Twitter
This is a lovely shop for quilting enthusiasts. Fabrics are from Moda and Hoffman (including Hoffman Batiks), and include lots of fab pre-cuts. There is a tremendous selection of quilting and textile books, and an excellent selection of quilting notions, including my favourite brands, Clover and Omnigrip. And they have great brands of wadding – definitely one of those really useful one stop shops when you are starting off on a new quilt project! There's a loyalty point scheme for online customers and deliveries are free on orders over £10. They have a real shop at Dobbies Garden Centre, Milngavie in Glasgow.
A specialist shop selling very beautiful traditional blue-printed cotton from Hungary. You can browse through the fabrics by design (flowers, abstracts, motifs etc.), and the minimum order is one Fat Quarter. Payment is by credit or debit card, and although this isn't terribly clear, there is a sliding scale of delivery charges (by weight), starting at just 95p for an order of a FQ.
Lady Sew and Sew
Lady Sew and Sew is a one stop shop for quilters – one of those extremely useful shops where you can pick up all you need for a patchwork project. They stock an excellent and extensive range of fabric (designers/makers including Kaffe Fassett, Tula Pink, Amy Butler, Valori Wells), wadding and quilting haberdashery, and they have quilting/sewing books and quilt kits too. You can browse by fabric designer or by fabric type (it would be great to have a browse by colour option too). There is a sliding scale of payments for delivery depending on order value, starting at £2.95 for orders up to £15, and you can pay by credit/debit card – I am not sure if PayPal is an option because it's not immediately obvious. If you want to check out their range in person,the Lady Sew and Sew warehouse in Henley is open on Monday each week and on other Open Days too.
Lady Sew and Sew on Facebook
Lady Sew and Sew on Twitter
Lovely Jubbly Fabrics
Stocks a decent range of contemporary quilting, sewing, and crafting cotton fabrics. Brands stocked include Makower, Dashwood, Riley Blake Designs, Michael Miller, Amy Butler, Tula Pink, Cotton and Steel, Free Spirit Fabrics and Benartex.
Lovely Jubbly Fabrics on Facebook
Lovely Jubbly Fabrics on Twitter
Lovely Jubbly Fabrics on Instagram
Lovely Jubbly Fabrics on Pinterest
M is for Make
This is a really great shop – with a very tasteful selection of fabrics, patterns, and a small but very useful selection of haberdashery, including Aurifil threads. You can make a payment using Visa, MasterCard or via your PayPal balance, all using PayPal. There is a flat rate charge for shipping of £2.75 to the UK.
M is for Make blog
M is for Make on Facebook
M is for Make on Twitter
MacCulloch & Wallis
Masses to choose from with the added bonus of huge quantities of gorgeous haberdashery and notions. You have to register before you find out what the postage price is, and VAT is not included until you check out, so working out what you are spending is tricky. Usually this would stop me including a shop in the list (so frustrating!), but M&W is such a treasure trove that I am making an exception.
Maud's Fabric Finds
Maud's Fabric Finds specialises in sourcing handprinted fabrics, eco friendly (or at least ethically produced) fabrics and small run fabrics. Definitely lots of goodies you wont find elsewhere. There's also a good range of haberdashery and sewing patterns.
Maud's Fabric Finds on Facebook
Maud's Fabric Finds on Twitter
Maud's Fabric Finds on Instagram
Meggy Magpie's Fabrics
I love the style! Some absolutely gorgeous fabrics here. Very retro – lots of classic modern stuff – Heals, 60s Sanderson etc. At present there's nothing very big, which limits your options a bit. I would love the opportunity to buy some bigger pieces.
Minerva Crafts
A one stop shop for quilters, dressmakers and crafters, and stitchers of all kinds, with a vast range of fabrics, patterns, sewing notions, haberdashery and more.
Minerva Crafts on Facebook
Minerva Crafts on Twitter
New Threads
Fantastic range of quilting fabrics (Moda, Lewis & Irene, Makower, Benartex are all stocked), notions and tools, including quilt wadding, extra wide quilt backing. They specialise in threads and needles, with Aurifil, Superior, YLI, Madeira, Gutermann, DMC all being available. and Aurifil threads.
Norfolk Textiles
Norfolk Textiles specialises in oil cloths and furnishing fabrics. The also stock vintage textiles including dressmaking fabrics, curtains, bedclothes, clothing and lace. If you are interested in getting a bargain then go to their Bargain Fabrics section (under Furnishing Fabrics on their slightly clunky menu system). This site isn't the most user-friendly in the world, but it's easy to find what you need, and I really like their selection of furnishing fabrics and oilcloths at pretty good prices.
Oakshott Fabrics
Oakshott sells a beautiful selection of fine quality handloom quilting cotton from Kerala in India. The collection includes shot, striped and textured cottons in an incredibly rich and wide selection of colours. You can read more about the production of their fabrics here on their website. You can see inspirational quilts made with these fabrics in their gallery.
Offset Warehouse
If you want to make sustainable choices in your crafting and sewing, and if you make accessories, clothes, toys or soft furnishings, then your first port of call should be Offset Warehouse. All the fabrics they stock are socially or environmentally responsible and this is clearly outlined on the site, with lots of resources about the ethics of fabric manufacturing. You can browse either by fabric type (types include denim, velvet, linen, terry, fleece and much more) or by fabric use, and there is also a search facility for the whole site. The pricing structure is excellent – the fabrics are affordable for people buying smaller quantities, but there are discounts for businesses wanting to buy larger quantities. I can't give precise information about delivery costs because it depends on the weight of the fabric and its origin – but it is all clearly explained just here.
Offset Warehouse on Facebook
Offset Warehouse on Twitter
Oh Sew Crafty
Review is on its way!
Organic Cotton UK
An exciting find! A lovely big range of all kinds of organic and fair trade fabrics. They stock calico, cord, velvet, linen, jersey, handloom cotton, bamboo and silk, many in beautiful colour ranges, and even have some amazing-looking herbal-dyed cottons. I really recommend taking a look, and reading more about their motivation on their About Us page.
Patch Fabrics
Fantastic stock of lovely fabrics, and everything else a quilter or sewist needs – just brilliant. There is a flat rate of £2.95 for shipping within the UK (orders over £75 are free). Payment is via the usual PayPal options.
Patch Fabrics Blog
Patch Fabrics on Twitter
Patch Fabrics on Facebook
Patchwork Dreamer
A good range of quilting fabrics, both traditional and modern, also a good selection of quilting tools and notions.
Patchwork Dreamer on Facebook
Patchwork Dreamer on Twitter
Pelenna Patchworks
This looks to be a really useful shop for the keen patchworker and quilter. I really like their well-chosen collection of stash packs – 8 pieces of 10″ square fabrics in co-ordinating colours – really useful for the beginner.
Pelenna Patchworks Blog
Pelenna Patchworks on Facebook
Pelenna Patchworks on Twitter
Plush Addict
Plush Addict started out as a super supplies shop for people wanting to make nappies for their babies, but over the past couple of years (whilst I wasn't looking!) but has developed into an incredibly well-stocked fabric (quilting cottons, flannel, PUL, fleece, Denim and more!) and haberdashery shop. They have a Plush Points Loyalty scheme, and postage charges are very fair, based on weight and with an option for 1st class, 2nd class or Special Delivery. Orders over £40 are sent free of charge and there is also a free returns service available (very rare, and very welcome).
Plush Addict Blog
Plush Addict on Facebook
Pretty Fabrics and Trims
A shop that definitely lives up to its name. Lots of very pretty quilting fabrics and gorgeous array of trims, ribbons, ric-rac and more. There's also a really good range of haberdashery and sewing patterns too.
Pretty Fabrics and Trims on Facebook
Pretty Fabrics and Trims on Twitter
Pretty Fabrics and Trims on Instagram
Prinfab offers you the opportunity to get your own designs onto fabric (there are 10 options of fabric, including cotton, cotton percale, poplin, linen and bamboo available) or buy fabric created by other artists/indie designers. It's also a place where you can sell your own fabric designs for commission payments. Think a UK-based version of Spoonflower. The prices for custom printed fabric start at £12.99 per metre, which is very competitive. If all this is intriguing to you – I recommend you check out the Prinfab Facebook page to see some examples of the fabrics which are being created.
Prinfab on Facebook
Prinfab on Twitter
Purple Stitches
Purple Stitches on Facebook
Purple Stitches on Twitter
Not a fantastic website, but a great range of quilting fabrics. They have a real life shop in Cromford, Derbyshire.
Quiltessential on Facebook
Quiltessential on Twitter
The Quilt Room
The Quilt Room is the home of well-known quilters and quilt designers Pam and Nicky Lintott and, as you would expect, has a great range of quilting fabrics, quilting supplies and haberdashery, magazines, books and patterns.
The Quilt Room Blog
The Quilt Room on Facebook
Quilters Cloth
Quilter's Cloth has absolutely tons of fabrics (Makower, Moda, Lecien, Amy Butler, Tanya Whelan, Wendy Slotboom amongst many more), fabric packs and a small selection of quilting tools and notions. You can search by fabric colour, pattern, collection, house or designer. The standard charge for delivery within the UK is £3.50.
Ray Stitch
A fabulous modern day haberdashers, with all sorts of beautiful fabrics, notions and, of course, habdash, for all your sewing needs. The standard delivery charge for orders under £20.00 is £2.50 and for orders over £20 it is £3.50.
Ray Stitch on Facebook
Ray Stitch on Twitter
The Remnant House
A very extensive range of more traditional fabrics for the dressmaker and quilter alike, The Remnant House bricks & mortar shop has been a Harrogate institution for more than 50 years. They also have a good range of notions and haberdashery. Online, there is a minimum order of 0.5m, but you can order in any increment above that. There is a flat rate of postage of £4.50 for orders up to £30, and delivery is free to the UK if your order is above £30. Payment is via credit/debit card or by PayPal.
Rooftop Fabrics
Plush (minky) fabrics, quilting cottons and more, including nappy making supplies.
Secret Garden Quilting
Secret Garden Quilting is well organised online store with a really great range of fabrics from Moda, Makower, Lecien, Robert Kaufman and more. I particularly like the good range of FQ bundles, that always offer at least a 10% discount over buying the fat quarters individually or fabrics by the metre. Another good money-saving bonus is that you can choose to have your parcel sent first or second class, with prices starting at £2.95/£1.95. Payment is via credit/debit card.
Secret Garden Quilting on Facebook
Sew Crafty
Sew Crafty on Facebook
Sew Crafty on Twitter
Sew Hot
Fabulous shop with a wide range of quilting fabrics, quilting notions and more. There's also a great range of patterns, kits, bag making supplies and more.
Sew Hot on Facebook
Sew Hot on Twitter
Sew and Make
Sew and Quilt
Sew & Quilt specialises in English Paper Piecing supplies and a fresh range of vintage-style quilting fabrics for today's quilter.
An all-rounder that sells supplies for needlecrafts of all kinds,knitting and crochet, as well as fabrics for quilters. They are specialists in the Tilda range, but also have fabrics from designers such as Amy Butler and Tula Pink too.
SewandSo on Facebook
SewandSo on Twitter
SewandSo on Instagram
SewandSo on Pinterest
Sew Over It
Stocks stylish dressmaking fabrics, a range of haberdashery and the Sewing Over It range of dressmaking patterns. They have 2 shops in London and run a range of very popular classes.
Sew Over It on Facebook
Sew Over It on Twitter
Sew Over It on Instagram
Sew Over It on Pinterest
Sewbox's has a lovely selection of top quality dressmaking fabrics and a fantastic range of dressmaking and accessory patterns including Colette, Hot Patterns, Serendipity Studio, Kwik Sew and more. There's also all the haberdashery and notions that you need to get started with dressmaking. There is a flat rate delivery charge within the UK of £2.50.
Sewbox Blog
Sewbox on Facebook
Sewbox on Twitter
Sewing Bee Fabrics
A great range of fabrics including dressmaking fabric, quilting cottons and more hard-to-get-hold-of fabrics such as neoprene, waterproof PUL, cuddle fleece. Good range of notions and haberdashery too.
Sewing Bee Fabrics on Facebook
Sewing Bee Fabrics on Twitter
Sewing Bee Fabrics on Instagram
The Sewing Studio
Well known as a sewing and embroidery machine specialist (you might recognise their former name Direct Sewing Machines) but now selling a good range of patchwork fabric too. They also run sewing classes and workshops at their shop in Redruth, Cornwall.
The Sewing Studio on Pinterest
The Sewing Studio on Twitter
Simply Solids
A great collection of designer quilting and sewing fabrics, Simply Solids specialises in Kona solids, but also stocks print fabrics too, and has an excellent selection of basics and blenders. There's also a good range of haberdashery and designer sewing patterns. They have a real life shop in Huddersfield.
Simply Solids on Facebook
Simply Solids on Twitter
Social Fabric
Nice selection of quilting fabric and some good own brand sewing and craft kits. There's a real life shop in Totnes, Devon.
The Spinster's Emporium
A very cool looking site with a great range of vintage fabric, amongst other things. There's also vintage yarn, haberdashery, trims, patterns, buttons and more. I really like their Vintage Fabric packs. If you are in the Nottingham area then you'll want to know that they have a real life shop and have regular crafting workshops. Deliveries to the UK are £2.00 plus 50p per additional unit purchased.
The Splendid Stitch
Great for dressmaking fabrics.
Terry's Fabrics
Upholstery and home dec fabrics.
Thread Head Fabrics
Fabrics for craft, quilting, dressmaking and home décor projects. Thread Heads also has a small range of indie sewing patterns and embroidery kits.
Thread Head Fabrics on Facebook
Thread Head Fabrics on Twitter
Thread Head Fabrics on Instagram
Thread Head Fabrics on Pinterest
Threads and Patches
A patchwork and quilting specialist, with a good range of some of the more inexpensive quilting fabrics, plus designer fabrics. There's also a fantastic range of quilting notions and tools, haberdashery and sewing/craft books. The Threads and Patches shop is near Bletchley and they have regular classes.
Threads and Patches on Facebook
Threads and Patches on Instagram
Great range of patchwork fabrics, including a really good range of their own patchwork kits. There's also a great range of sewing/patchwork notions and haberdashery, although not everything (threads for instance) is available online. The Tikki shop is near Kew Gardens in west London.
Tikki on Instagram
Tikki on Twitter
Trixie Lixie
A great shop for dressmaking and quilting fabrics. Trixie Lixie also stocks an excellent range of indie sewing patterns, loads of great sewing kits (lovely for gifts!), and a great range of quilting and sewing notions, haberdashery, ribbons and trims. It's well worth a visit to enjoy the quirky, fun-loving feel, as well as doing a bit of shopping.
Trixie Lixie on Facebook
Trixie Lixie on Twitter
Truro Fabrics
A wonderful array of fabrics, especially for dressmakers, although this shop would definitely be of interest to quilters and crafters too. The search facilities are excellent – you can browse by type of fabric, and colour, and you can do a full search of the site too. There's a photo of each fabric, and they offer a sample service too. You can pay via PayPal or credit and debit card. Orders up to £9.99 are posted at £2.50, and over £10, the delivery charge is £5.99.
This website is extremely inviting and easy to use – you can search by type of fabric, manufacturer, designer, collection, colour, pattern and price! The Village Haberdashery also has a thoughtful selection of notions and other vital equipment to sewing and quilting, like wadding, cushion pads, sewing patterns, buttons, zips, ribbons and trims. And if you are into embroidery, knitting or crochet, there's lots of goodies for you too. Payment is via credit or debit card (SagePay), or Paypal and the flat rate delivery charge for parcels in the UK is £2.75.
The Village Haberdashery Blog
The Village Haberdashery on Facebook
The Village Haberdashery on Twitter
Vintage Fabric and Curtains
This Ebay store is a real treasure trove of great vintage fabrics, and is one of those helpful Ebay stores that is well arranged and easy to browse. There's an associated website, where you can buy coordinated bundles of vintage fabrics.
The Vintage Fabric Market
The Vintage Fabric Market is a wonderful treasure trove of fabrics, haberdashery, vintage patterns, accessories and more. I love the layout of the site and the professional appearance – it's all very well laid out and easy to browse. My particular favourite things here are the really fun and useful fabric packs and fabric squares which look to be great for stash building. The Vintage Fabric Market are also now selling their own hand-printed, vintage-inspired fabric.
The Vintage Fabric Market Blog
The Vintage Fabric Market on Facebook
The Vintage Fabric Market on Ebay
Vintage Textiles by Lilly
A treasure trove of all kinds of vintage fabrics including curtains, tablecloths, traycloths, linen and dressmaking fabrics too. A great resource if you want to shabby-chic your house, and the big lengths of fabric means that it's definitely worth a look if you are into bag making, making clothes or making patchwork. There's also a huge stock of vintage patterns. This is an Ebay store.
Viva La Frida (oilcloth)
Viva La Frida specialises in Mexican Oilcloth which is a durable, flexible, vinyl-coated fabric – hugely useful and there's some gorgeous designs here. Payment is by credit/debit card via Paypal or cheque. Delivery is charged by amount spent, and starts at £1.99 for orders under £10.
Viva La Frida Blog
Viva La Frida on Twitter
Whaley's of Bradford
Whaley's specialise in providing unprocessed raw fabrics for dressmaking, dying, theatre and film productions. A great source for fabrics in their natural state.
White Tree Fabrics
Great range of quilting fabrics, craft fabrics and dressmaking fabrics, plus a fantastic selection of haberdashery, notions and patterns. A very well organised website- and if you are a student you will be glad to know that with your NUS number, you will get a 25% discount.
White Tree Fabrics on Facebook
White Tree Fabrics on Instagram
The Wool Felt Company
As the name suggests, the focus of this shop is entirely on wool felt. They sell 100% wool felt in a brilliant range of colours, which you can order by the sheet, 1/2m or full metre (which is not always easy to do in other shops selling felt). They also have an equally extensive range of wool blend (30%), which although not quite so wonderful as the 100% version, is a lovely product and a little less pricey. Although this is a new (2012) venture, the people behind it already run the wonderful fabric shop Fabric Inspirations, so they have a proven track record. There's a flat delivery fee of £1.95 per order, which is a real bonus too.
The Wool Felt Company on Facebook
You, Me and Mabel
A good range of quilting fabrics, and a small selection of haberdashery and notions, including a well-chosen selection of Aurifil neutral threads.
You, Me and Mabel on Facebook
You, Me and Mabel on Instagram