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Actions by the Federal Reserve are having strong effects on the price of stocks, bonds, and other financial assets in the economy. You can see this effect clearly on Fed meeting days, which are associated with large market movements.
A question we tackled in an earlier post was: what assets bear the most risk of surprise Fed announcements on the direction of monetary policy? We are following up on that post because we now have another observation: the March 19th, 2014 Fed meeting which was Janet Yellen's first meeting as Fed chair.
The meeting released information that the Fed planned on tightening sooner than markets expected — many attributed the market's reaction to some combination of FOMC forecasts and Yellen's statement that there would likely be 6 months between tapering ending and increases in the target Federal Funds Rate.
So we now have three days where we observe the Fed "surprising" markets with new information on the pace of tightening:
- 06/19/2013, or the "taper tantrum," when the Fed announced that they wanted to begin the conversation of tapering QE purchases of long-term government bonds and mortgage-backed securities, a signal of tightening.
- 09/18/2013, or the "taper headfake," when the Fed unexpectedly decided to hold off on tapering, a signal of looser monetary policy.
- 03/19/2014, or the "Yellen first conference," when the Fed surprised the market with quicker tightening than most previously expected.
So what investments bear "Fed risk"? As we did before, we choose to look at ETFs available from Vanguard. This was an arbitrary choice – we just wanted to examine broad asset classes. We deleted a few because there were too many to see clearly on charts.
We then take the single-day returns on these three days to see which investment move the most. Those that move the most on these days are those that bear the most Fed risk. As we will show below, there is an amazing degree of consistency across the three events in the assets that bear Fed risk. This is despite the fact that the first and last event occurred 9 months apart! So there really seems to be a "Fed risk factor" on which some investments load.
We start with the punchline, and those interested can see more details below. Here is a ranking of the investments, where the investment on top of the list bears the most Fed risk, and the investment on the bottom bears the least:
1 Intermediate-Term Corporate Bond (NASDAQ:VCIT)
2 Short-Term Corporate Bond (NASDAQ:VCSH)
3 Intermediate-Term Government Bond (NASDAQ:VGIT)
4 Utilities (NYSEARCA:VPU)
5 Mortgage-Backed Securities (NASDAQ:VMBS)
6 Global ex-U.S. Real Estate (NASDAQ:VNQI)
7 Long-Term Corporate Bond (NASDAQ:VCLT)
8 Consumer Staples (NYSEARCA:VDC)
9 FTSE Emerging Markets (NYSEARCA:VWO)
10 Short-Term Government Bond (NASDAQ:VGSH)
11 FTSE Pacific (NYSEARCA:VPL)
12 Long-Term Government Bond (NASDAQ:VGLT)
14 FTSE Europe (NYSEARCA:VGK)
15 FTSE All-World ex-US (NYSEARCA:VEU)
16 Emerging Markets Government Bond (NASDAQ:VWOB)
17 Growth (NYSEARCA:VUG)
18 Telecommunication Services (NYSEARCA:VOX)
19 Health Care (NYSEARCA:VHT)
20 Total Stock Market (NYSEARCA:VTI)
21 Industrials (NYSEARCA:VIS)
22 Materials (NYSEARCA:VAW)
23 Value (NYSEARCA:VTV)
24 Mid-Cap (NYSEARCA:VO)
25 Information Technology (NYSEARCA:VGT)
26 Consumer Discretionary (NYSEARCA:VCR)
27 Small-Cap Growth (NYSEARCA:VBK)
28 Small-Cap (NYSEARCA:VB)
29 Mid-Cap Growth (NYSEARCA:VOT)
30 Mid-Cap Value (NYSEARCA:VOE)
31 Small-Cap Value (NYSEARCA:VBR)
32 Financials (NYSEARCA:VFH)
33 Energy (NYSEARCA:VDE)
Bond funds bear a lot of Fed risk, and that shouldn't be too surprising. The cash flows that bonds pay are pretty certain — what is uncertain is the discount rate used to value today the future cash flows, and the Fed has a strong effect on that discount rate. What is particularly interesting, however, is that it is not the long-term bond funds that bear the most risk. It is the intermediate-term bonds. John Cochrane suggested that this might be because the Fed likes to buy in the intermediate part of the yield curve.
Emerging market equity funds also bear a lot of risk, coming in 9th on the list. This one is less obvious, because the connection between actions of the Federal Reserve and emerging market economies needs a few dots in between. Hyun Song Shin has done a great job outlining what these connections might be.
When it comes to the stock funds, we are still thinking through them. The fact that financials bear so little risk seems surprising. If you have some strong views about what is going on with equities in particular, please leave comments!
There are a lot of interesting implications. For example, do investments that bear more Fed risk provide higher expected returns for investors, especially during the past 4-5 years of unconventional monetary policy? Does volume in these investments go up or down right before Fed meetings? A lot to ponder. But what seems undeniable is that certain assets bear a lot of Fed risk, and they tend to be the same assets across all three episodes.
Ok, more details for those interested. Here are the charts of the returns for the three dates mentioned above. The returns are calculated as follows — we take the single day return, subtract off the average daily return of the historical series, and scale the whole thing by the daily standard deviation of the historical series. So these returns reflect how unusually large the movement was relative to average daily movements.
It's easy to see that the market's reaction to Yellen's first meeting as FOMC chair was smaller (in absolute value) than the reaction during the taper tantrum and taper headfake.
But what is remarkable is how strongly correlated the reactions are among the investments on the three dates. In other words, the same investments that react the strongest to one event also react the strongest to the other two. Here are scatter plots that show it.
Given the very strong correlation across events, our ultimate measure of risk is just adding up the returns on the three dates, where we multiply the tightening days by -1 (taper tantrum and Yellen first FOMC) before adding. The list at the beginning of the post shows you which positions bear the most Fed risk.
Disclosure: No positions


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Nazism, Philosophy and Scholarship: Where Are the Lines Drawn?
How much should a scholar's beliefs impact the credence and importance of his work?
Join this discussion on Friday, Sept. 9, at 1 p.m. in the Africa Room of the Duquesne University Union at the inaugural event for the philosophy department's 50th anniversary celebration.
Martin Heidegger, perhaps the most influential philosopher of the 20th century, was interested in the study of "Being" and contributed to phenomenology, existentialism and other philosophical realms. But this giant of a thinker also rejected democracy and supported Nazism in Germany.
"He was appointed chancellor of the University of Freiburg by Hitler, and complied with and wrote in support of the Nazis," said Dr. James Swindal, acting dean of the McAnulty College and Graduate School of Liberal Arts, previously the chair of the philosophy department. But given Heidegger's political stance, is it valid to continue to research him given his troublesome historical political context?
The controversy has long swirled around Heidegger, and the Pittsburgh discussion will start with a screening of the German-made documentary Only a God Can Save Us that tells much of his involvement with the Nazi party. A panel discussion will follow with Duquesne's own Tom Rockmore, a leader in the critical efforts to unearth Heidegger's collaboration with the Nazis, and Ted Kisiel, Distinguished Research Professor Emeritus of Philosophy at Northern Illinois University—and the first full time doctoral graduate of the DU philosophy department 50 years ago.
At the time of Heidegger's pro-Nazi work in the 1930s, his fame already had been established, Swindal said. Yet, when the philosopher died in 1976, he had yet to fully address or come completely to terms with this political position.
Still, Swindal said, "Those who believe in the importance of his scholarship say his work should continue to be examined with little regard for his past, while others contend that the historic events must shape the way he's seen.'"
Duquesne's philosophy department has had a strong reputation in the interdisciplinary teaching of phenomenology and existentialism since the early 1950s. The department continues its commitment to providing resources and training for students interested in studying this rich tradition.
Duquesne University
Founded in 1878, Duquesne is consistently ranked among the nation's top Catholic research universities for its award-winning faculty and tradition of academic excellence. The University is nationally ranked by U.S. News and World Report and the Princeton Review for its rich academic programs in nine schools of study for nearly 10,000 graduate and undergraduate students, and by the Washington Monthly for service and contributing to students' social mobility. Duquesne is a member of the U.S. President's Higher Education Community Service Honor Roll with Distinction for its contributions to Pittsburgh and communities around the globe. The U.S. Environmental Protection Agency and the Princeton Review's Guide to Green Colleges acknowledge Duquesne's commitment to sustainability.

subset: commoncrawl


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CHICAGO -- An MRI exam on St. Louis Cardinals outfielder Jon Jay's right shoulder has revealed no structural damage and there are no plans to put him on the disabled list.
Jay was injured when he crashed into the center-field wall at Busch Stadium on Thursday, trying to track down Drew Stubbs' seventh-inning home run in a 6-3 loss to the Cincinnati Reds.
The team sent him back to St. Louis to get checked out after he experienced discomfort during batting practice on Sunday.
Jay is hitting .349 with two homers and four RBIs on the year.
Cardinals manager Mike Matheny said Jay may be available to pinch run during the team's three-game series against the Chicago Cubs, which starts Monday night.


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Gas tax, IJH dominate legislative forum
Three local legislators got an ear full on the need to pass a gas tax from the three Marshall County Board of Supervisors during the Marshalltown Chamber forum Friday.
Supervisors Deane Adams, Denny Grabenbauer and Dave Thompson told Rep. Dean Fisher, R-Garwin, Rep. Mark Smith, D-Marshalltown, and Sen. Steve Sodders, D-State Center, a gas tax is needed to pay for roads and bridges.
"I think people are working to try and come up with a solution," Sodders said.
Fisher said while he is in favor of a tax, it's been a tough sell on the majority of his constituents. Adams said if the tax is not put on the road user the cost of road and bridge repair would fall on property taxes.
A bill passed in the Iowa Senate this week on the need for a juvenile home in the state to serve delinquent girls, though the bill didn't indicate it had to be in Toledo – the site of the now closed Iowa Juvenile Home.
Smith and Fisher would like to see a bill in the House that does indicate it should be in Toledo.
"I am adamant that this facility should be in Toledo," Smith said. "I'm not willing to compromise on the location of the Juvenile Home."
Fisher said he continues to try to line up support for the reopening of IJH with his fellow House Republicans.
"It's not a real clear path on that, but we're working on it," Fisher said.
Sodders said he continues to work on expanding broadband Internet to unserved and under-served areas in the state. A sticking point on a bill is the money it's going to take to provide incentives to communications companies to provide access to these areas.
"This is still a three or four year project," Sodders said.
The House passed a bill this week which dealt with the use of drones in private areas. Smith said he thinks legislators should find better things to do than talk about drones.
"I continue to think we need to be looking at jobs and job growth and education issues," Smith said.
The Marshalltown Chamber is sponsoring a trip to the State Capitol Wednesday as part of its annual summit trip to meet with state legislative leaders.


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I had a very good interview with Irvin Baxter this evening. One hour long. You may listen to it here. While Irvin believes that the Antichrist will come from the Roman Empire, we had a great discussion. I was also pleased to learn that Irvin also shares with myself and Dave Hunt the conviction that Gog and the Antichrist are one and the same.
Baltimore Christian Examiner: Joel Richardson is author of The Islamic Antichrist, a book whose premise is that Islamic eschatology is sort of a mirror opposite of Christian eschatology. Joel has also written several other books but this is his ministry not his business. Joel has dedicated a lot of his time to studying Islam so that he can share the truth of the Gospel with Muslims and share what he has learned with fellow Christians.
I first met Joel at a local church where he was invited to speak about the Islamic Antichrist. I had never heard anything like this theory before and at first I thought he was completely off base with his theology about the end times because it was different than anything IӤ heard before. However, since that time IӶe been following his ministry on his website Joelӳ Trumpet and have found that his viewpoint definitely has merits and should not be quickly dismissed. Mainstream prophecy teachers who hold the standard dispensational views of the end times have been quick to shoot down Joelӳ ideas. A bit too quick in my view.
Last week Joel gave me an interview and I asked him a few questions about his book and ministry. I think his answers reveal a lot and are very educational.
Below are the questions I asked but Joelӳ answers are paraphrased.
What inspired you to write the book?
To make the church aware of Islamic eschatology. So people can see that Muslims have been setup by their religious system to fulfill prophecies of the Bible. They have been set up to embrace anti Semitism and embrace the Antichrist.
The book is also targeted to Muslims, not just Christians. Muslims get very deep into theology and so the answers are precise and the book is worded in a way to reach Muslims. While I believe their prophecies need to be looked at I do not believe Islam is prophetic.
Who is the Mahdi?
Islamӳ primary messiah figure, they believe in him as well as Jesus. By and large the majority of Muslims do believe in the coming of the Mahdi (also spelled Mehdi.) This belief is espoused by an overwhelming majority of respected Muslim scholars throughout history.
Sunnis in recent times have emphasized the coming of Jesus but Shia Muslims have emphasized the coming of the Mahdi. Over the past ten years however there has been a massive groundswell of belief in the Mahdi across sectarian lines. I have every book on the subject (about 40) and only two of those books donӴ follow this direction. Some Muslims believe that Jesus and the Mahdi will be one in the same.
How does Islam look at Jesus?
They see him as another Muslim prophet in a long line of prophets to reawaken the religion called Islam. Mohammed was the final prophet. They believe Jesus will come back to end Christianity and show that Christians had it all wrong and that the Bible was all wrong. There is a famous tradition that says Jesus will; break the cross, kill the pigs and abolish the Jizya (the Jizya is the tax that subjected people pay to exist in Islamic dominated countries.) They believe the Jesus will remove all crosses from churches. Jesus will expose that Christians eat unclean food. And no longer will a dhimmi status be accepted, people of any and all other religions must convert to Islam or die. Muslims also believe Jesus will kill the Antichrist. They think the Antichrist will be who the Jews will follow as their messiah. They believe the Antichrist will have miraculous powers.
The Islamic version of the Antichrist is called the Dajjal. He is supposed to be one eyed or blind in one eye (speculative) according to pop culture in Islam. Islam is filled with conspiracy theories. Some see the all seeing eye and freemasonry as an all encompassing Dajjal system. Similar to the way some conspiracy theorist view the Ԯew world order.ԠThereӳ even a website called the Dajall New Network.
Itӳ my belief that Satan knows Godӳ plan and has had a long time to study it and theology throughout the ages. So Satan has his own plan and part of that plan is to build an army and the primary method for that army is Islam.
How did you get started with studying Islam?
I went to school to become a missionary to the Islamic world. I lived in the Middle East for a while also. I came back to the US and went to school for engineering as a tent making career. While I was there I spent a lot of time reaching out to Muslims on campus.
I developed a real love for Muslims. One of the reasons for that is that I love to discuss theology and most people donӴ want to talk about theology but Muslims do want to talk to you about it and at length. I was also moved by hearing about the 10/40 window of un-reached people.
Why didnӴ you become a missionary?
My life changed and was taking me in different directions. But after 9/11 a lot of Americans converted to Islam. There was something powerful (not in a good way) about it.
Americans are honest and wanted to know what Islam was all about. People would go online to Muslim websites just looking for answers. Muslims at these sites are generally trained to tear down Christianity and western civilization and that feeds on the self hatred and guilt people of the West sometimes have about their self and their culture. Many Christians and those in the West donӴ know or understand their own theology and culture very well either. At the same time Muslims on these sites would present a westernized version of Islam to get people in the door.
After seeing people convert to Islam online I realized that I could have an online ministry and not have to travel to be a missionary.
Do you believe the Antichrist will come from Islam and why?
I do and the evidence is beyond circumstantial. More than just their eschatology being the opposite of Christianity, Biblical geography points to the Antichrist kingdom of that of the surrounding nations of Israel and not of a Roman Empire or revived Roman Empire. The Antichrist theology also matches with Islam. Islamӳ creed, the shahada is the most Antichrist creed that has ever existed.
I want everyone to take the Islamic paradigm and consider it. I donӴ want to change all of the Christian outlook on eschatology but to expand the horizons to spread out and look at all directions for the fulfillment of Christian prophecy. We are to be watchmen on the wall and right now I think many people are ignoring the Eastern wall.
Calvin, Martin Luther and Jonathon Edwards all looked at Islam as vehicle of the Antichrist. I think bad eschatology can lead to pain and confusion. I just want to share my heart and correct the imbalance of looking only at a Roman empire as the vehicle of the Antichrist.
What makes you think the Antichrist will come soon and that we are living in the end times?
The trends toward Muslim domination in Europe and the Middle East is a big end times indicator I think. Also the Middle East peace push seems to be an indicator. There has been such a push for so long that I think something will eventually come out of it. I think the next major sign post will be the rebuilding of the (Jewish) temple.
Talk about the threats that you get for spreading your beliefs?
Islam allows people to hate, murder and men to live very sexually and to have legal prostitution. In Islam all is acceptable in the name of God. Mohammed was a warrior, and so followers of Islam see themselves as warriors. Muslims get to experience the rush of religion and the freedom to hate. Radical Islam has a lot of appeal.
Joel Richardon: WND: An al-Qaida video just released on YouTube titled "The Mahdi Army" reveals for the first time the deep degree to which al-Qaida views itself to be the prophesied apocalyptic Mahdi army. While this is something I and other observers of Islamic apocalyptic movements have been very suspicious of for years, this video… Continue Reading
Another somewhat common idea that I have seen passed around prophecy circles for years is the notion that the "Gog" of Ezekiel 38,39 cannot be the Antichrist because Gog receives a burial and Antichrist does not. This idea comes from a surface reading of the two following passages: But thou art cast out of thy… Continue Reading
Throughout the Body of Christ, or more specifically that portion of the Body of Christ that pays attention to Biblical Prophecy, there is a question about whether or not "Gog" of Ezekiel 38,39 and the Antichrist are one and the same. One of the issues that some point to in order to claim that Gog… Continue Reading
I got this critique via e-mail. I do not know Jacob Prasch but have heard good things about him and his ministry. My general feeling after skimming through is that he tried to be fair and generous in some places, but not so much in others. Presently, I don't have time to write a small… Continue Reading
WND: Joel Richardson: If you are a student of Bible prophecy, I have some shocking news. I want to shatter a very popular prophecy myth. Russia is not about to invade the land of Israel. In fact, Russia is never even spoken of in Biblical prophecy. Despite all of the hype and discussion that has… Continue Reading


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A fast-moving brush fire burned through more than 500 acres of Angeles National Forest in California this afternoon, claiming at least one structure and threatening power lines, according to CBS Los Angeles. Tweeters are using the hashtag #PowerhouseFire to keep tabs on the path of the flames.
Smoke from the flames is visible for miles.
In just the last hour, Forest Service estimates have grown from 400 to 600 acres or more.
* * *
The fire has now consumed more than 1,000 acres of brush, according to the latest reports.


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The Ride 9 Reflex is out of the lab and ready to run. Now featuring EVERUN, the Ride 9 delivers the signature neutral running experience with more energy return than ever before. EVERUN is a dramatically more lively and responsive material positioned closer to the foot via Topsole construction, providing smoother landings in the heel and reduced pressure in the forefoot. The Ride 9 truly makes every mile feel as effortless as your first.
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Tue, 22 Jan 2013|
Should get our draft pick back!
Related Videos:
Tue, 17 Jan 2017
Each has a solid path to a Super Bowl win
tom brady found at 0:33, 1:19
Tue, 10 Jan 2017
nick saban found at 1:25
Mon, 2 Jan 2017
sean payton found at 1:26, 2:08
Fri, 30 Dec 2016
Only thing between Falcons and #2 seed is us
explosive offensively found at 0:55
Automatically Generated Transcript (may not be 100% accurate)
Litigate again everybody gave everybody thinks coach Sean Payton officially reinstated. You think there's only piece -- the -- -- -- that. Everything that. Yeah -- juicy fruit is back. The popularity. As well as you know the commission also suspended juicy fruit -- and -- bank regulation. We'll get their choose their own level income. Yeah I kind of look at this scenario. Where okay. It's a coincidence that all of us and as the deadly for the NFL and you bring -- back I think. And with the saints season was over. And they weren't gonna wait till. Clock struck midnight after it's doable to me -- think it was pretty that this is always in the world. Who knows that probably he probably until the estimated that -- things organization. Just to stand and media and -- -- You know you're in this week so that that's surprising -- -- that's only. Papelbon all right let them pull olive olive branches would invasion. We're not only. And there are penalized in the saints obviously -- the 2012 season but going forward. Who wanted to truly put this behind this get things back there. Second round draft pick of the 2013. Trapped or not has to be talking about it and they ended April. He's made his statement. He's gotten everyone's attention. You know going forward -- performance bonus scandals you'll have teams involved in net. I think he made at this point for so players -- -- would not tolerate that. That's Cleveland all Republican or so. I think the next step. Up and truly need to be on the back burner and kind of moving forward. We've human commissioner. And you might do that Google is that the State of the Union Address numbers and -- -- reporters who will in my. Also make an open war thing. I was in the second round draft significantly because you don't Warner and they're also the 2013. Season. Is you put this behind you and and things fans don't appreciate you can.


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Karl Miller, Mandy Siegfried, et al. Set for SCR's Completeness - Mar 23, 2011
South Coast Repertory to Produce Itamar Moses' Completeness in 2011 - Aug 6, 2010Read more related articles


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Central Texas College plans to commemorate World AIDS Day with a special event Monday at its Killeen campus.
The event will feature representatives from Darnall Army Medical Center and Central Texas Support Services providing prevention information and free HIV testing to students.
Darnall staff will bring a quilt honoring local residents who died due to HIV/AIDS. Students will have the opportunity to add their own "panels" to the quilt.
This year's event is free and open to the public.
It will take place at the college's Anderson Campus Center from 10:30 a.m. to 12:30 p.m.
Contact Chris McGuinness at firstname.lastname@example.com or (254) 501-7568. Follow him on Twitter at ChrismKDH.


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The Couchbase Client Library 1.2-Beta includes a new API for some basic cluster management. There are methods for creating, removing and listing buckets. There are similar methods for managing design documents. These new features are found in the new class CouchbaseCluster, under the Couchbase.Management namespace. The main benefit of this new API is that it's now possible to allow your application to create its bucket and set its design documents when it starts up.
One of the overloads for creating new design documents allows you to specify a Stream as the source of the design document. With this version, it's easy to create design documents from a set of files. You can also just specify a string containing the document.
I recently had an idea to create a simple command line utility to use these design doc management methods to automate the creation of basic views. The result of this idea is up on GitHub at https://github.com/jzablocki/couchbase-model-views. Using this framework, you'll be able to automate the creation of views simply by decorating your existing model classes with custom attributes.
Consider a Beer class with a properties for Name, Description, Brewery and ABV.
public string Id { get; set; }
public string Name { get; set; }
public string Description { get; set; }
public float ABV { get; set; }
public string Brewery { get; set; }
This class maps to "beer" documents in your Couchbase bucket.
"name": "Samuel Adams Summer Ale",
"abv": 5.2,
"type": "beer",
"brewery_id": "110f04db06",
"description": "Bright and citrusy, brewed with mysterious grains of...
To achieve this mapping, you'd likely use Newtonsoft.Json's property mapping attributes.
public string Id { get; set; }
public string Name { get; set; }
public string Description { get; set; }
public float ABV { get; set; }
public string Brewery { get; set; }
Using two new attributes found in the CouchbaseModelViews.Framework project, you could further decorate this class to declare which properties in this class should be indexed by Couchbase Server. These attributes are CouchbaseDesignDocument and CouchbaseViewKey.
public class Beer
public string Id { get; set; }
[CouchbaseViewKey("by_abv_and_name", "name", 1)]
[CouchbaseViewKey("by_name", "name")]
public string Name { get; set; }
public string Description { get; set; }
[CouchbaseViewKey("by_abv_and_name", "abv", 0)]
public float ABV { get; set; }
[CouchbaseViewKey("by_brewery", "breweryId")]
public string Brewery { get; set; }
The CouchbaseDesignDoc attribute is set on a model class. It uses a plain-old-CLR-object (POCO) to define a design document. If you omit the name argument, a design document with the same name (lowercased) as the class will be created. If you omit the type argument, views will check that documents have a type property with the value of the name (lowercased) of the class.
The CouchbaseViewKey attribute is set on properties in a POCO class that should be indexed. For example, the Name property in the Beer class above has a CouchbaseViewKey attribute on it with the arguments "by_name" and "name." The view that will result from these values is as follows:
if (doc.type == "beer" && doc.name) {
emit(doc.name, null);
The "by_name" argument is the name of this view and the "name" argument defines what property is checked for existence and emitted.
It's also possible to include composite keys by decorating multiple properties with CouchbaseViewKey attributes containing the same value for the viewName parameter. Composite keys are demonstrated with "by_abv_and_name" on the ABV and Name properties. Notice also that there is an optional order parameter that allows you to set the order in which properties are emitted.
if (doc.type == "beer" && doc.abv && doc.name) {
emit([doc.abv, doc.name], null);
Once you've decorated your class with the appropriate attributes, you can use the CouchbaseModelViewsGenerator project to run the models through the view generator. This is a simple command line project that requires an app.config with a section listing all assemblies containing models that will be used to create views.
<section name="assemblies" type="System.Configuration.DictionarySectionHandler"/>
<add key="DemoModels" value="CouchbaseModelViews.DemoModels" />
Additionally, you will need to configure the CouchbaseCluster. CouchbaseCluster instances are creating using the same configuration (code or app.config) as the existing CouchbaseClient. However, there are now an additional two properties you can set to provide the administrator credentials.
<servers bucket="default" bucketPassword="" username="Administrator" password="qwerty">
<add uri="http://localhost:8091/pools" />
Once you've setup your app.config, make sure you have the listed assemblies in the bin directory where they can be loaded. The easiest way to achieve this discover-ability is of course to reference them. However, if you just want to use a compiled version of the console app, then simply copy them into the bin directory.
When executed, the framework will create a "beers" design document that looks like the following:
"views": {
"by_abv_and_name": {
"map": "function(doc, meta) { \r\n\t if (doc.type == \"beer\" && doc.abv && doc.name) { \r\n\t\t emit([doc.abv, doc.name], null); \r\n\t } \r\n }"
"by_name": {
"map": "function(doc, meta) { \r\n\t if (doc.type == \"beer\" && doc.name) { \r\n\t\t emit(doc.name, null); \r\n\t } \r\n }"
"by_brewery": {
"map": "function(doc, meta) { \r\n\t if (doc.type == \"beer\" && doc.breweryId) { \r\n\t\t emit(doc.breweryId, null); \r\n\t } \r\n }"
The console contains no actual view creation logic. It just orchestrates calls to the various plumbing components inside the Framework project. If you prefer to include the view creation inside of Global.asax or some other app start event, you could simply make these calls yourself. There are four primary components of the framework.
- The ConfigParser simply reads the list of assemblies from the config section and generates an enumerable list of assemblies.
- The ViewBuilder class takes an assembly or enumerable list of assemblies and iterates over each of the types. For each type found with a CouchbaseDesignDoc attribute, views are constructed. The Build method of the ViewBuilder returns a dictionary, where the keys are design doc names and the values are the actual design docs.
- The DesignDocManager takes a dictionary with doc name, design doc pairs and uses the CouchbaseCluster to create design documents.
- There's also a ViewRunner class, which will run the newly created views.
var builder = new ViewBuilder();
var designDocs = builder.Build();
var ddManager = new DesignDocManager();
ddManager.Create(designDocs, (s) => Console.WriteLine("Created {0} design doc", s));
var runner = new ViewRunner();
runner.Run(designDocs, (k, v, s) => Console.WriteLine("[{0}::{1}] Key {2}", k, v, s["key"]), 5);
There is no coupling between any two of these three components and you can use them as you wish. If you have your own assembly gathering facility for example, simply pass it to the ViewBuilder.Build to render the JSON needed to create the views.
At this point, the framework is mostly complete and reasonably tested. The code has a few more loops than I'd like and I might have overused Tuples , but it works. Feel free to use it in your projects. Keep in mind, this is a Couchbase Labs project and isn't officially supported. Remember too that it's using the Beta version of the .NET Couchbase Client Library and the API is subject to change.


text:
Written on: 26/03/2010
I was really happ with my PETITE STAR ZIA and have been for the past year. I knew the basket was so ridiculously small before I bought it, so that didnt bother me. The rain cover has since split at either side by the handles which is annoying and today, well, my 15 month old son leaned to one side and the whole thing tipped over!!!!!! I phoned the manufacturer who patronisingly told me that if I read the instructions that you should always have one hand on it at all times.....!!!! any parent of kids knows that this is nigh on impossible to do ALL the time, I just thank God I moved fast enough to stop him cracking his forehead on the floor. This buggy is also apparently suitable for up to 2 stone 5!!! I dont think so, not after whats just happened!. Other than that major factor, its excellent for under 12 months I would say, very cosy and my son sleeps very very well in it with the cosy toe, so if you want one then I would say yes its great, but once baby is starting to try and escape then get another like a maclaren.
As rated by our community of reviewers
" Mini Kids Warrington - best deal on iCandy " Read More
" Stylish and comfy but not pratical! " Read More
" I have had this pushchair for 3 years and now on second child....it... " Read More
" Nice " Read More
Written by LeathClem004
" Do not buy ! " Read More


text:
Check in from 15h / Check out prior to 12h
Grand Hyatt San Francisco: Find photos, reviews, information, amenities and compare prices for 4 stars hotels in San Francisco, United States.
Only two minutes from Union Square Plaza, Grand Hyatt San Francisco is located centrally in San Francisco. It is ideally located for guests wishing to visit the area's popular attractions.
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text:
Google's email service, Gmail, influences procedure for adopting a brand new feature that notifies an individual whether it detects that the mail user has brought have been sent with an unencrypted connection. Similarly, the sender is notified upon discovery which he offers to send an e-mail over a connection that isn't encrypted.
The plans to introduce this selection was announced last November.
Though e-mail might have confidential information, the total number of mail transmitted over connections into a limited extent prevents anyone from accessing data transmitted. This is especially true if you send e-mail to a recipient that uses a different mail server than oneself.
Because the sender or receiver has normally only control of the connection between ones own e-mail client and e-mail server the application of. Such a thing happens often using encrypted e-mail protocols or perhaps a web client that uses HTTPS.
Date with the link between the e-mail server you have yourself and the server that this recipient uses. Google states that 42 percent of all e-mail messages received by Gmail, is transferred from another mail server via non-encrypted connections. From the other direction, the proportion of 18 percent.
This means less interception of e-mail.
The notification will never be particularly intrusive. It involves a padlock icon seems with all the messages you will get or plan to send.
Incoming mail usually carries a lots of data regarding how transportation has happened, such as the link between email servers purchased TLS encryption.
The new Gmail notification tells of messages has or possibly going to be sent over an unencrypted connection. The notification is not linked to any possible type of end-to-end encryption. Illustration: Google
The search engines do not specifically, one can believe that the alert displayed to Gmail users who're going to write an e-mail, in line with the e-mail address (es) as specified by the person and checks the servers being receive email, supports TLS encryption for messages on the road.
Gmail will henceforth even be clearer mark emails that come from non-authenticated senders. If you open an email message in Gmail, it is usually images, logo or avatar next to the sender name. But to any extent further this is replaced by a picture of a question mark when the message can't be authenticated.
The reality that an e-mail message won't contain authentication information, should never imply that you'll find nothing scary over it. But should perhaps be considered a little careful once you open these emails. Coming message apparently from your traditional bank or perhaps a large e-mail providers like Google, Microsoft or Yahoo, however a high probability that the message is falsified whether it can't authenticate.
More details visit our new internet page: about me


text:
Thomas Hartung, MD
- Professor
Departmental Affiliations
- Environmental Health and Engineering (Primary)
- Molecular Microbiology and Immunology (Joint)
Center & Institute Affiliations
Contact Information
615 N. Wolfe Street
Room W7035
Baltimore, Maryland 21205
MD, Tubingen, 1992
The main goal of my work is toward a paradigm shift in toxicity testing to improve public health. Due to my background as head of the European Center for the Validation of Alternative Methods of the European Commission (2002-2008), I am involved in the implementation of the 2007 NRC vision document "Toxicity Testing in the 21st Century – a vision and a strategy". I have furthered the translation of concepts of evidence-based medicine to toxicology (evidence-based toxicology). This aims for systematic assessment of the quality of all tools for regulatory toxicology and the development of new approaches based on annotated pathways of toxicity (the Human Toxome).
I have a broad background in clinical and experimental pharmacology and toxicology documented in more than 450 publications. Previous work centered on the immune recognition of bacteria, including pyrogen testing, and the induced inflammatory response. In experimental and clinical approaches, the pharmacological modulation of these responses was studied. I have relocated to the US early 2009 and established beside the directorship for the Center for Alternatives to Animal Testing (CAAT) a laboratory for developmental neurotoxicity research based on genomics and metabolomics the respective technologies were made available by a Thought-Leader Award from Agilent.
Honors and Awards
2001 Business Innovation Award of the region lake Konstanz for the development of an alternative pyrogen test
2002 RIVM Award at the World Conference on Animal Use and its Alternatives
2003 Environment Award of the Landesbausparkasse Baden-Wuertemberg
2004 Steinbeis Technology Transfer Award
2005 Paula and Richard von Hertwig-Preis for interdisciplinary collaboration
2006 US Society of Toxicology Enhancement of Animal Welfare Award
2009 Russell & Burch award of the Humane Society of the US
2010 Agilent Thought Leader award
2014 EuroGroup for Animals – Animal Welfare Award
2014 LUSH award: Lobbying Prize
April 2016 478 Papers (in Medline-listed Journals with Impact-Factors 2013, total 1768.5) 8 Patents h-factor: 58 (Web of Science) / 67 (Google), over 16.500 (Researchgate) / 18.000 (Google) citations Statistics Top-10 journals Nature (IF 38.6): 3 articles Circulation (IF 15.2): 1 article J. Exp. Med (IF 13.2): 2 articles Angew. Chem. (IF 13.7): 1 article Advanced Drug Delivery Reviews (12.9): 1 article Hepatology (IF 12.0): 1 article Journal of Allergy and Clinical Immunology (IF 11.5): 1 article J. Hepatology (IF 9.9): 1 article PNAS & Trends Biotechnology (IF 9.7): 3 & 1 articles Blood (IF 9.1): 4 articles Nature protocols (IF 8.0): 1 article 10 most frequent journals ALTEX (IF 4.1): 124 articles ATLA (IF 1.4): 33 articles J. Immunol. (IF 5.5): 19 articles Infect. Immun. (IF 4.1): 11 articles Human Exp. Toxicol. (IF 1.5): 10 articles Toxicol. In Vitro (IF 2.7): 9 articles J. Biol. Chem. (IF 4.7) 9 articles J. Immunol. Meth. (IF 2.2): 8 articles J. Inf. Dis. (IF 5.9) / Eur. J. Immunol. (IF 5.0) / Immunobiol. (IF 2.8): 6 articles each Some recent publications below
- Luechtefeld T, Maertens A, Russo DP, Rovida C, Zhu H and Hartung T. Analysis of publically available skin sensitization data from REACH registrations 2008-2014. ALTEX 2016, 33, 135-148. http://dx.doi.org/10.14573/altex.1510055.
- Maertens A, Bouhifd M, Zhao L, Odwin-DaCosta S, Kleensang A, Yager JD and Hartung T. Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of over-representation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis. Arch. Toxicol. 2016, in press.
- Samuel GO, Hoffmann S, Wright R, Lalu MM, Patlewicz G, Becker RA, DeGeorge GL, Fergusson D, Hartung T, Lewis J and Stephens M. Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: a scoping review. Environment International 2016, in press.
- Stephens ML, Betts K, Beck NB, Cogliano V, Dickersin K, Fitzpatrick S, Freeman J, Gray G, Hartung T, McPartland J, Rooney AA, Scherer RW, Verloo D and Hoffmann S. The emergence of systematic review in toxicology. Toxicol Sci, 2016, in press
- Hartung T. Making big sense from big data in toxicology by read-across. ALTEX, 2016, 33:83-93.


text:
Imagine for a second that you're the kind of person who posts their personal phone number to Twitter. I know, I know, it's tough, but bear with me. So you do this, and then you get a bunch of texts giving you some facts about cats and asking you to tweet "Meow, I <3 Cat Facts" at Edward Snowden to make it stop. Yeah, that guy. You heard about him on the news a few times. You think he's a terrorist. And now he's sending you unsolicited texts. Did he hack your phone? Whatever, you just want to make the cat facts stop. So you tweet "Meow, I <3 Cat Facts" at Ed Snowden.
RT LadyDitheAuthor: Snowden "Meow, I <3 catfacts" please remove my number 478-283-7755 from your texts list. Thank you.
— JoeJoe (@1234joejohn) November 18, 2015
Okay, thought experiment over. This drama is real, and has played out dozens upon dozens of times on Twitter over the last week. A hacker who said they "try to keep my hat as white as possible" in an email has unleashed a torrent of cat facts on people foolish enough to leave their numbers exposed on the public platform. The live Twitter feed for "Meow, I <3 Cat Facts" is thus a thing of beauty, and maybe art. But there's a lesson here.
To unsubscribe, tweet @Snowden "Meow, I <3 catfacts" Stop spamming me with this!!!!!!! Ps: I hate cats!
— Paola Bisoneaux (@bisoneaux) November 12, 2015
"I've found Twitter user's operational security failures interesting," the programmer behind the cat facts gag wrote me in an email. "People get angry when they get their cat facts, but they don't realize that this could be a perfect vector for spreading mobile malware or performing other attacks. Think of Android Stagefright or phishing them into installing a malicious app."
don't give out your phone number kids - @Snowden Meow, I <3 catfacts pic.twitter.com/KyqZMGggCm
—  (@artaimh) November 18, 2015
The hacker said they're using an automated script to scrape Twitter's API (which means they have access to the site's data), and then using an anonymous texting app called Anonytext to send out the messages. Apparently, it was pretty easy, especially when so many people leave their numbers out in the open. But why rope Snowden in?
"He likes cats, and I thought people might find it funny if they thought Snowden was texting them," they wrote. "Turns out most of the meowers don't even know who Snowden is."
Well, no shit.


text:
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Allow at the very least 24 hours, preferably 48 hours before you decide to even go searching for your refills, remember this is really a very busy business then when your call also comes in it just gets added to the pile prior to deciding to. It is projected that the majority of pharmaceutical capital will turn from brand to specialty drugs over the next several years. As which organization to select, this is dependent upon your personal situation. Pharmacy technicians who may have their CPh - T or are GPh - C registered may also have essentially the most interesting, challenging and rewarding positions throughout their career. Americans tend to be aware now than ever before regarding the serious health risks connected with using tobacco, may it be smoking cigarettes, smoking out of a pipe, or using chewing tobacco.
(The same those who think that teaching kids about std's is exactly the same as telling an adolescent to have sex. Are you concerned about contamination of wild plants with lead, chemicals, and dog doo. Other Online Pharmacy Technician Schools and Training. But a pharmacy technician, a top school student at the time, antifungal zyvox treatment typed on Beth's prescription label a dosage 10 times over antifungal zyvox treatment her doctor prescribed. The antifungal zyvox treatment light of focus is slowly shifting about bat roosting generic drugstores that provide exactly the same features and similar medications but in a much inexpensive price points that easily fits the pockets of the common man.
The drugs are all in alphabetical order so it is easily located. Certain pharmacy schools accept students immediately after high school graduation. Check your medicine cabinet regularly to view the remaining amount of pills. They have toll free numbers worldwide and email numbers in order that one can contact in their mind easily. I had never really caused people before, just animals who were pleased to get my company and don't got angry, so I wasn't sure the best way to react.
Most technicians work 35-45 hours every week in hospitals and people retail pharmacies which might be open twenty-fours a day. Before placing your order, make sure which you go over the privacy policies along with the terms and types of conditions given around the website. However, be aware that not all websites while using. In spite with the differences in duties, you can find requirements which can be similar no matter the location where the pharmacy tech works:. Pharmacy reviews on the internet were founded across antifungal zyvox treatment the perception that individuals must realize the real truth about all internet sites where purchasing is required.


text:
The Fast-Fold® Truss Frame Screens are designed for versatility and durability in rental and staging environments, and accommodate nearly any size of surface. The frames bolt together with Speedy Cranks for efficient set up and tear down without tools. Front and rear projection surfaces can be interchanged, and adjusted up or down in six inch increments. A rugged carrying case ensures ease of transport and storage.
- Product: Fast-Fold® Truss Frame Screens
- Net Picture Area: 10.5 x 14 ft
- Overall Size: 11.5 x 15 ft
- Format: Square
- Fabric: Da-Mat


text:
Per vedere questo video hai bisogno di HTML5.
Actors: Megan Rain
Categories: Brunette - Toys - Dildo - Masturbation - Teen - Solo
Source: immoralliv
Description: Megan Rains plays one hour with her cute toys in solo scene
Published on 2015-03-10
Megan Rains Pleases Herself
Young Megan Rains Wants That Dick Deep!
Megan Rains Shows Off Her Bouncy Booty
Dick Sucking Contest with Megan Rains & Rachelle Richey
Cock Sucking CHALLENGE: Megan vs. Jennifer
Megan Rains & Bibi Noel tag team Porno Dan
All Natural Skylar Green And Kassandra Rains Are All Ready To Fuck
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Going Wild Sucking Pricks Left And Right
Ass Fucking Sessions
Megan The Rod Rider Shows Her Skills
The content of this page is reserved for mature adults.
To view the page click on "Enter" or click "Exit" to return to the homepage.
Enter - Exit


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You may also like
Ratings for Dr. Solomon Kamson
It's amazing how many victims have reported this want-to-be doctor and nothing has been done. He had 45 complaints that warranted full investigations with the Dept of Health since 1998. 14/45 resulted in disciplinary actions. That's just the tip of the iceberg of his sketchy business practices.
Dr Kamson did surgery on my back and changed my life .I am grateful.
explain the procedure so I could understand. And was He there for me during surgery and the recovery time and made sure I had nothing to worry about other than getting better,
My father-in-law was going nowhere for two decades through Tricare (medical military) and had lost all hope. His back was so freakin' messed up from serving his country that he suffered to the point of concluding that suicide was the only option. Us family members searched in a panic for someone who could "save him." That man was Doctor Solomon Kamson. He literally saved his life! Not only was the attention he gave to his back above-and-beyond, but he dove deep and got him to talk about deep emotional scars in which he made arrangements for him to have more specified help for. I can't say enough good things about this man. No one has ever cared. But he came along and cared, a lot. I'm not the type to review anything but my kids have a "papa" because of him so I thought he deserves a "shout out."
Folks, be SURE to read ALL of the comments on this site BEFORE you see this man. He is an Anesthisiologist, No surgical training other than a lesson on a Cadaver on a Cruise ship. (Unless he went back to college since he was suspended) All of these recent good ratings are by him or his staff. Please be VERY careful in deciding on a back surgery. (See a Board Certified NEUROSURGEON, not an anesthesiologist......makes sense, RIGHT??) There are only a handful of great surgeons out there. Investigate them yourself because Washington does NOT have a Medical Review Board, so it is up to YOU to determine if a doctor is properly trained/qualified. You WILL wait in his office for EVER to see him, too.
Words can not express my gratitude for Dr. Kamson. My back at 67 years is better than it has been all my life. I had also had a lot of trouble with my feet which must of been compensating for my back. Now my feet are pain free too. I was in so much pain pain killer wouldn't even touch the pain. Dr Kamson took the time to explain and so I felt comfortable with the surgery. Dr Kamson is ahead of his time.
This is the best I have ever been treated by a doctor/surgeon. Dr. Kamson is so compassionate, understanding, extremely knowledgeable and well worth the visit. I had to have a cervical decompression at C-5/6 and C-6/7 as I was diagnosed with severe spinal stenosis. I was told by other specialists (a neurosurgeon & orthopedic surgeon) that if I didn't get the surgery I would end up with permanent nerve damage and paralyzed due to the pressure on my spinal cord. I had disc bulges and bone spurs (one was pressing on my spinal cord) from wear and tear, aging and arthritis. I was terrified to get the surgery done and was also terrified what would happen if I didn't get it done. I postponed the surgery for 2 years. It was the referred pain down the arms to my hands as well as down my legs to my feet (radiculopathy) that led me to my surgical decision. It took just about a year to find a surgeon that practices the minimally invasive technique that I could totally trust. When I found Dr. Kamson and met with him and his staff, it didn't take me long to have the decompressive surgery. Dr. Kamson gave me all the time I needed to ask questions and he answered every one of them. He held my hand and made me feel comfortable, less anxious and that reassured me about my surgical decision. His assistant, nurses, staff and anaesthetist were extremely caring, helpful, knowledgeable and went above and beyond my expectations. I wished I would have done the surgery sooner now that I know what a professional, knowledgeable and caring doctor Dr. Kamson is. He and his "team" are a very exceptional people. I would totally recommend Dr. Kamson in a heart beat.
Dr. Kamson recommended surgery for a spinal injury I suffered. After recovering from surgery, my back was better than before I was injured. He is extremely knowledgeable and great bedside manners.
Very good doctor! Explains things so well. The staff also knows a lot. The nurses are very nice and helpful throughout the whole thing (cortison injections done). You do have to wait a bit but in the end you get a lot of info!
Dr. Kamson worked magic on my lower back. My pain was a constant 8 or 9 out of 10 and now it's 0! I couldn't be happier! He really takes the time to get to know his patients and find out how their pain is affecting their lives. Highly recommended!
Dr. Solomon Kamson's Credentials
Facility Affiliations
Accepting New Patients
- Washington Univ Sch Of Med, St Louis Mo 63110 (Grad. 1982)
Other Specialties
Areas of Expertise
Awards & Recognitions
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Top Hospitals in Bothell, WA
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i watch hockey and write poems, some get published, some don't. i write to music, particularly james blake and bon iver. i love everything my wife cooks, Iceland, and wine.
featured work in Cactus Heart Press and PUBLIC POOL. a collection of poems in Lady Business Anthology of Poetry (Sibling Rivalry Press), can be found in the Library of Congress' Rare Book Collection.
BA and MA in creative writing from san francisco state university.


text:
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Al Fresco is a style of dining that is casual and often party-like in its atmosphere but before we discuss the joys and beauty of al fresco, let's get something out of the way. Am I the only one that "over does it" when the sun finally comes out?
Last week finally produced warmer temperatures and sunshine so I mowed, weeded, shoveled, planted, re-arranged and on and on until I basically couldn't stand up straight. I think I was so excited to be outside that I just kept going way past what my body should of done. Please tell me that I'm not alone!? LOL!
After two days of resting my sore muscles and joints I needed to finish mowing the back yard and guess what I did…I played around with setting up my outdoor dining table for some festive al fresco dining…nope, no mowing got accomplished at all. It still isn't done as of the writing of this article, but life's short and having fun while fussing with flowers and seashells is much more interesting than mowing a slightly overgrown lawn :O)
So let's get back to the topic at hand – alfresco dining at the beach cottage. I moved our outdoor dining table onto a grassy area of the yard since I'm getting ready….gearing up….getting everything ironed out…almost going to start….re-doing and repairing our old back deck. The table looked so lovely sitting in the long grass that it just begged to be decorated with some pretty flowers, seashells and such.
There is something romantic about eating outside. I collected some Mason jars, seashells, starfish, snippets of branches from a backyard tree to create an easy breezy beach cottage table. A favorite sun-bleached piece of driftwood created the perfect centerpiece.
I still have no idea what kind of tree produces these gorgeous little white flower clusters, but I love them. The blooms are delicate so the light breeze blew a few little petals across the tabletop; which I left since they seemed to just add to the romantic affect of the setting.
I found a bundle of white linens at a local thrift shop a few months ago…25 cents for the stack. They are all different sizes and have a delicate pattern embellished on them. A few have been used for small table runners and others for napkins. The material is very soft and extremely washable – two of my favorite things. Jute twisted around a fabric napkin, with a few seashells glued on the ends provide an inexpensive, unique and adorable napkin ring.
The combination of natural driftwood with ruffly white flowers flowing out of old glass jars just makes me happy.
A simple grilled chicken salad, sourdough bread and some fresh berries made a simple lunch menu. If you keep a basket in the house full of linens, candles, shells or whatever you want to use for outdoor dining then it makes it super simple to set up your table…in no time at all.
If you're wanting to give al fresco dining a try then just remember…there is no right or wrong! Use things that you love, that you already have and that make you smile.
p.s. Minnie is my little flower child – she always hangs out with me while I'm outside. She has decided that she enjoys laying right in the center of our Lily of the Valley flower bed this year…she likes to hide in there like she's a lion on the prowl or something (she is ALL bark and no bite!). I had to take a quick photo of her, well…'cause…she is so darn cute!
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The role of pharmacokinetics (PK) and pharmacodynamics (PD) has increased dramatically as anticancer drug discovery and development has shifted towards molecularly-targeted therapies. Increased appreciation of PK/PD relationships has resulted in greater emphasis on generating and analyzing such data, even for agents without defined molecular targets. Recognition of drug-drug interactions and pharmacogenetic differences in drug metabolism, disposition, and susceptibility has increased the need for assays to define relevant polymorphisms and their clinical impact. The Clinical Pharmacology Analytical Facility (CPAF) was established in 1994 to provide state-of-the-art pharmacology research facilities forthe University of Pittsburgh Cancer Institute (UPCI). The CPAF occupies 1,000 square feet of laboratory space in the Research Pavilion of the Hillman Cancer Center. The CPAF supports many UPCI CCSG programs in addition to the extensive UPCI preclinical and clinical pharmacology research activities ofthe Molecular Therapeutics and Drug Discovery Program. Services include quantitation of drugs, metabolites, and other materials;identification of metabolites;and PK and PD analyses of anticancer agents undergoing preclinical and/or clinical evaluation at UPCI. The CPAF also uses in vitro methods such as human hepatocyte cultures and subcellular fractions, such as microsomes and cytosol, to characterize the cytochrome P450 isoforms and other key drug-metabolizing enzymes responsible for producing metabolites identified. The CPAF provides important consultative services to UPCI investigators on the design of pharmacologic studies and drug assays, metabolism, and PK analyses. The CPAF is co-directed by Drs. Merrill J. Egorin and Jan H. Beumer and overseen by an advisory committee representing the Schools of Medicine and Pharmacy, and the Biostatistics Facility. During the past 6 years, the CPAF has provided support for 21 Cancer Therapy Evaluation Program (CTEP)-sponsored clinical trials at UPCI, 10 investigator-initiated clinical trials at UPCI, 28 CTEP-sponsored clinical trials at other NCI-designated cancer centers or cooperative groups, and 35 animal pharmacology projects. It also provided analytical chemistry support for 3 in vitro pharmacology studies. To expand its capabilities and increase its value, the CPAF has enhanced substantially its analytical chemistry instrumentation, its PK modeling software, and its personnel. Since the last competitive renewal of the UPCI Cancer Center Support Grant, the Facility has acquired an additional 2 LC-MS instruments and 2 LC-MS/MS instruments. Also since the last competitive renewal, the CPAF competed successfully to serve as the Pharmacology Core Laboratory for the Gynecologic Oncology Group and successfully recompeted its role as the Pharmacology Core for the Cancer and Leukemia Group B. The CPAF continues to be a major collaborator of the University of Southern California Biomedical Simulations Resource, thereby allowing the CPAF to implement sophisticated PK and PD modeling software. The requested CCSG funding will support Facility personnel for their efforts in providing consultative services related to assay development, methodology, protocol design, and data interpretation, and their efforts to ensure that instrumentation and software are suitably maintained and available for application to projects by investigators seeking support from the Facility.
|Zhang, Xuan; Bresee, Jamee; Fields, Gregg B et al. (2014) Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo. Bioorg Med Chem Lett 24:3786-90
|Oborski, Matthew J; Demirci, Emre; Laymon, Charles M et al. (2014) Assessment of early therapy response with 18F-FLT PET in glioblastoma multiforme. Clin Nucl Med 39:e431-2
|Gross, Neil D; Bauman, Julie E; Gooding, William E et al. (2014) Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer. Clin Cancer Res 20:3289-98
|Beumer, Jan H; Owzar, Kouros; Lewis, Lionel D et al. (2014) Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103). Cancer Chemother Pharmacol 74:927-38
|Yang, Liangchun; Xie, Min; Yang, Minghua et al. (2014) PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat Commun 5:4436
|Sun, Xiaofang; Tang, Daolin (2014) HMGB1-dependent and -independent autophagy. Autophagy 10:1873-6
|Pollock, Sheri L; Rush, Elizabeth A; Redner, Robert L (2014) NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation. Leuk Lymphoma 55:1383-7
|Ng, Yuen-Keng; Lee, Jia-Ying; Supko, Kathryn M et al. (2014) Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment. Melanoma Res 24:207-18
|Popovtzer, Aron; Normolle, Daniel; Worden, Francis P et al. (2014) Phase I trial of radiotherapy concurrent with twice-weekly gemcitabine for head and neck cancer: translation from preclinical investigations aiming to improve the therapeutic ratio. Transl Oncol 7:479-83
|Peterson, Lanell M; Kurland, Brenda F; Schubert, Erin K et al. (2014) A phase 2 study of 16*-[18F]-fluoro-17*-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC). Mol Imaging Biol 16:431-40
Showing the most recent 10 out of 463 publications


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52 posts tagged with scale.
Displaying 1 through 50 of 52. Subscribe:
Multi-touch Scale?
Is there such thing as a scale that can weigh multiple items at once (as in, display their individual weights)? [more inside]
What are these white things on the stems of my blueberry plants?
These white growths were on the stems of one of my blueberry plants here in Washington, DC. I guessed they weren't anything beneficial and they popped off pretty easily in the cold. The inside/undersides are sort of pinkish red. What are they?
Large scale web applications running on Windows
As a long time Linux Engineer I enjoy reading about the technologies used by sites like Twitter, Facebook, Etsy, Yahoo (for things like Flickr) and other large sites to build things out to scale. I often lend a hand with Windows customers at work and it recently occurred to me that I've never seen a website or blog posts that relate to scaling on Windows. [more inside]
Top tips for personal measuring scales?
My personal scale has died, so I'm in the market for a new one. Any tips? [more inside]
Scale, scale on the floor.
My new bathroom scale doesn't work. [more inside]
How to informally implement a sliding scale for tutoring services?
I am a math tutor in the walk-in tutoring center at the community college and I get asked by a lot of students if I do private sessions off-campus. I ask $20/hr, which I am told by my colleagues is a perfectly reasonable rate. However I realize that $20/hr is prohibitively expensive for a lot of people at community college, and I know that a lot of people I tutor could afford $30/hr or more. How do I tactfully offer a discount to someone who needs it while charging a higher rate to those who can afford it? [more inside]
Best kitchen scales
Looking for kitchen scale recommendations. [more inside]
Help me help my brain learn how to scale up and down with precision in Adobe Illustrator.
If I scaled the artwork up by typing 173.95% into the scale dialog box in Adobe Illustrator, what percentage do I scale it down by in order to get it back to its original size. Is there a simple equation that will do this operation? [more inside]
We have also weighed limes.
The lovely Mrs. Haddock and I were given a digital kitchen scale as a wedding gift, but we have no idea what we should be doing with it. What should we be doing with it? [more inside]
Recipes for kitchen scales
I have a brand new kitchen scale. Where do I find recipes that are by weight instead of volume? [more inside]
Looking for a scale subway map
Can you direct me toward a scale map of the New York City transit system? [more inside]
What is the origin of the 20-80 scale used in baseball scouting?
What is the origin of the 20-80 scale used in baseball scouting? [more inside]
Talking the talk from Kuwait to Kinshasa.
I have need for a large and strange batch of audio translations. As a newbie to this game, please help me zero in on market specifics. [more inside]
43% body fat. What the hell?
43% body fat. Am I about to drop dead, or is my scale wrong? [more inside]
Macro, Meso, ??, Micro, Nano
I need help with some terminology of scale. Is there a term for something on a scale between "meso" and "micro"? Alternatively, I'd be happy with something higher than "macro" or between "micro" and "nano" (but I'd rather avoid that one if possible). [more inside]
Barbegal water wheel?
I want to build a model of the water wheel and gearing system as seen in this episode of James Burke's Connections. [more inside]
"sliding scale options available"
I'm interested in checking out the local hackerspace -- partly out of interest in doing stuff there, partly because they do work that's similar to ours (they work with adults, we work with kids). Their pricing policy is very expensive and only seems to make a token effort to reach out to low-income people like myself. They've expressed interest in meeting and getting to know us -- I'm excited about this, but am also really personally affronted by their pricing scheme. How do I get over this so we can have a conversation? [more inside]
How can I repurpose a digital kitchen scale with broken LCD?
I have a digital kitchen scale on which the LCD has crapped out. By pressing on different parts of the ribbon cable connecting the LCD to the circuit board, I've determined that there are multiple shorts or shoddy connections on the cable. There doesn't seem to be an easy way to fix it, so I'm wondering if anyone has any ideas for ways I can repurpose it for a fun electronics project. I have some basic electronics knowledge and soldering experience.
Mass Produce Homemade Pottery
I am interested in creating a serving dish (bowl) that I think would sell rather well... If i make a prototype and want to mass produce it and say sell on Etsy.com how would I do this? [more inside]
what is the dorian scale good for
how do you use dorian scales in jazz guitar? [more inside]
Help me make objects to scale for an architectural plan.
Help me make objects to scale for an architectural plan. [more inside]
How do you draw the line about which racists to call out versus which ones to let slide?
When people my age say something against gays or against blacks I try to call them out. When my 81 grandpa says something I just let it slide figuring he was raised that way. What rules do you personally use to reconcile this kind of conflict? [more inside]
My grandpa passed on. This is some of his stuff!
My grandpa died. Some stuff remains. Will you be my personal Antiques Roadshow? [more inside]
Where did the Scale go?
My hot water pot and coffee machine suddenly (over a period of 2 days) simultaneously completely descaled themselves, leaving piles of scale on their bottoms. This despite no use of descaling agents, or any other efforts to do this. I am thinking something must have changed with our tap water to have done this, but can't imagine what this would be. Any thoughts or other possibilities?
Mistake in federal job announcement: Recourse in holding agency to terms?
Federal HR experts: Due to an "unfortunate mistake," I am being offered a salary less than that which is listed on the federal job announcement. This after investing an enormous amount of time, energy etc. in the application process. Do I have any recourse? [more inside]
Create scale animation in Photoshop?
I am trying to create an animated button in Photoshop CS4 which includes a logo scaling down and moving a bit across the animation. I've created two frames that I'll tween between, but no matter what I do, when I scale the logo it changes in both frames. I've turned on and off the three unify buttons and the propagate frame 1 checkbox, and I've scaled using Transform and with the move tool options, every time it scales in both frames. Moving it from one position to another works just fine. Can anyone help?
Where to find a good weight chart for the kitchen?
I'm looking for a poster showing the weights of various commonly used ingredients. [more inside]
The time machine in back to the future was just a DeLorean covered in ______. What's the word for _____?
Prompted by the success of a previous post, I have another special effects question. Is there a term of art for the stuff like extra model kit parts and other doodads glued to a model to give it a sense of scale and complexity? [more inside]
Fitness level for body fat scale
My body fat measuring scale requires me to give it parameters: Age, Height, Gender, and Fitness Level (1, 2, or 3). What should I enter for fitness level? The instructions just say something like "enter your fitness level on a scale from 1 to 3". Does anyone have a similar product and have a rule of thumb for this?
What is the best digital scale for humans?
I'm trying to lose some weight and people have recommended weighing myself every day, as motivation or somesuch. I was wondering if you have a digital scale that you absolutely love, and if so, what the name of it is. Thank you.
Help me scale an image in Photoshop
Help me scale an image so that part of it is a specific size using Photoshop CS3. [more inside]
0.1 gram scale
recommendations for a 0.1 gram accuracy scale that does not reset if you tare it to 0 and then remove the weight and has a capacity of more than 1kg? [more inside]
Cleaning scale from pool tile
How can I best clean hard water scale from pool tile? [more inside]
How many times do I need to weigh a given object to overcome the scale's inaccuracy?
If I have a scale that is accurate to .1 grams and I want it to be accurate to say, .05 grams, how many measurements do I need to take to do this? Can I even do this? [more inside]
help me not kill my new lemon tree!
Help! I was just given a potted lemon tree! What do I do? [more inside]
What's the radio scale bar for?
A number of radios I've owned in my life, in addition to the AM and FM frequency labels, also have a "Scale" label, going from 1 to 10, across the range of frequencies. What's this all about? Is it ever used for anything? I've never heard a radio station say "Tune to 6 on your Scale Bar".
Recommend a postal scale?
Have a recommendation for a postal scale? [more inside]
How to create automator action to resize images to a certain width?
How do I create an automator action to resize images to a certain width? The "scale images" action only resizes the longest side, which is sometimes the height, not the width. [more inside]
Domestic Help - How Much?
Domestic help? How much? Laundry, dishes, beds, straightening up, occasionally driving the kids to the sports practices. [more inside]
A VNC-like program that can scale high resolutions?
I use VNC on computer A, 1680x1050 resolution, to control computer B, 1920x1080 resolution. This results in a lot of scrolling. Anyone know of a better solution that's also free or very cheap? [more inside]
Good Sliding-Scale Therapist Resource for L.A.?
Anyone know a good resource for finding a good sliding-scale therapist in the Los Angeles area? [more inside]
A Problem of Scale: Halfway in size between an atom and the universe
"A human is halfway in size between an atom and the known universe"... This is a paraphrased quote I have come across several times. I like it. Who said it first? How true is it in the most literal sense? And, finally, what errors arrive in postulating a universe, or an atom, which can be measured AT ALL from our singular, relativistic, perspective? [more inside]
Name That Book
Name That Book Filter: I recall a book that was based on the eloquence and development of a scale. I believe it was about the Saffir-Simpson Hurricane scale... Maybe the Richter Scale. Did I just imagine this book? If not, what is the title author of said book?
RSS Over Time
How does a typical RSS feed behaves over time, as the content grows? [more inside]
Help me find bathroom scale that measures body fat.
Help me pick a bathroom scale - with decent BODYFAT SENSOR. Lost url of a review from about a year ago that had good info on common models. The googles do nothing for that particular review, however [more inside]
Does "economies of scale" really make a business efficient?
Economies of Scale [more inside]
Yellow scale in toilet pan
Why am I getting a an unpleasant buildup of scale on my toilet and how can I stop it? [more inside]
PHP - resize image to a specific (k) size?
Formula to resize an image (in PHP) so that the resulting file is roughly a certain size in bytes? [more inside]
Recommend an accurate bathroom scale
I would like to buy a cost-effective bathroom scale that is pretty darn accurate for a 200 lb. guy -- margin of error plus or minus one pound. How do I buy one that is accurate? Any brand name suggestions? Do I have to buy one of those things with manually adjusted weights that run along a bar to get this level of accuracy? Please do not instruct me not to weigh myself more than once a week, etc. -- I am looking for a set of scales that will give me a reliable snapshot.
Firefox page scaling?
Firefox filter: I like Firefox but everything looks tiny on my high res laptop screen. Is there a trick to make it "fit to window" like Opera does? [more inside]
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Description of this paper
PRG420 (Version 10) - Week 2 Individual- Simple Commission Calculation Program Part 1- An A++ Work!!!
Write a Java? application using NetBeans? Integrated Development Environment (IDE) that calculates the total annual compensation of a salesperson. Consider the following factors;? A salesperson will earn a fixed salary of $35,750.;? A salesperson will also receive a commission as a sales incentive. Commission is a percentage of the salesperson?s annual sales. The current commission is 12% of total sales.;? The total annual compensation is the fixed salary plus the commission earned.;The Java? application should meet these technical requirements;? The application should have at least one class, in addition to the application?s controlling class (a controlling class is where the main function resides).;? There should be proper documentation in the source code.;? The application should ask the user to enter annual sales and it should display the total annual compensation.
Paper#66696 | Written in 18-Jul-2015Price : $22


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Printable PDF
Vendor: Microsoft
Certifications: MCSA
Exam Name: Transition Your MCTS on SQL Server 2008 to MCSA: SQL Server 2012, Part 2
Exam Code: 70-458
Total Questions: 109 Q&As
Last Updated: Jan 15, 2017
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*correction, about 90 percent valid
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text: My professional background is in algorithmic proprietary trading with a basis in quantitative research. Having led systematic strategy research efforts in both Fortune 500 and start-up hedge fund enterprises, my experience spans asset classes and instruments. Like many others, I came to the world of finance from a technical educational background, in my case Control Systems, an applied math field mostly populated by engineers. My research from those days has been published in academic journals and presented at conferences. I was drawn to the investing sector because it connects math and human behavior. My recent book "Value in Volatility" is a practitioner's guide to the mathematics of leveraged ETFs, the price action of which is a generalization of 'standard' stocks/ETFs. As such, it is also a guide to the math of market assets in general. The earlier "Leveraged ETFs" is a comprehensive exposition on the mathematics of this misunderstood class of financial instruments.


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This week's list of CEO purchases focuses on those CEOs who have purchased at least $100,000 of stock in their own company on the open market in the past week or so. These are significant purchases and may indicate a coming catalyst and confidence in the company.
As I've mentioned before, I think companies with recent insider purchases are great places to find stocks worth researching and I prefer CEO purchases over director purchases because you know that CEOs are closer to every day issues.
Below are nine stocks where the CEO has recently purchased at least $100,000 of company stock:
Lorillard (NYSE:LO): Lorillard is an interesting stock. It had been driven down because of the regulatory threat of a menthol ban, which is a cause for concern since they're the leading menthol cigarette maker. If you're interested in learning more about the specific threat and what it means for Lorillard, I recently wrote the following article and I encourage you to read it: Lorillard Reports Smokin' Earnings, But Uncertainty Looms.
CEO Murray Kessler seems to be confident in the stock, and will be picking up a 6.5% yield from their newly raised dividend. Kessler bought 12,500 shares on February 18 totaling nearly $900,000.
American Water Works Company (NYSE:AWK): American Water Works is another big dividend yielder at 3.2%. They provide water and wastewater services in the United States and Canada and have a $4.8 billion market cap. CEO Jeffry Sterba bought $109,000 worth of stock on the open market on February 17.
Cherokee (NASDAQ:CHKE): Staying on the dividend theme, Cherokee is going the other direction. They cut their dividend last month, but still yield 4.7% after the cut. CEO Henry Stupp bought $181,500 of company stock on February 17 at $18.15 per share. The stock is now in the low $17 range. Cherokee manages brands and licenses products, primarily clothes, to a variety of retailers.
NetSol Technologies (NASDAQ:NTWK): NetSol is a small $100 million market cap software company. CEO Najeeb Ghauri owns about 3.5% of the company. On February 16, Najeeb bought another $200,000 of company stock on the open market. Ghauri and his family have been picking up company shares for years and have never sold a share.
Datawatch (NASDAQ:DWCH): CEO Michael Morrison owns more than 4% of the company and purchased 30,000 more shares on February 15 and 16. He owns about 350,000 shares directly and indirectly. Morrison just became CEO on February 14, replacing Ken Bero. Datawatch is a Massachusetts-based software company serving 44,000 organizations worldwide. Its market cap is only $30 million.
PennyMac Mortgage Investment Trust (NYSE:PMT): CEO Stanford Kurland participated in a secondary offering for the company and purchased 50,000 shares at $18 on February 16. PennyMac is using the proceeds to purchase two residential mortgage loan portfolios. PennyMac is a REIT that paid out $1.19/share in dividends in 2010. Management appears to be bullish on this transaction as evidenced by Kurland's $900,000 investment in the offering and the COO's $180,000 purchase.
Two Harbors Investment (NYSE:TWO): Two Harbors is another REIT focused on residential mortgage loans. CEO Thomas Siering bought 30,000 shares on February 16, totaling $318,000. He was joined by five other insiders making purchases within a few days of his purchase. Siering owns 155,000 shares. The REIT paid out dividends of $1.60/share in 2010. If they keep the pace this year, the stock would yield nearly 15%.
Coca-Cola Enterprises (NYSE:CCE): CEO John Brock bought nearly $180,000 worth of shares on February 15. He currently owns about 180,000 shares. Coca-Cola Enterprises is the third largest Coke (NYSE:KO) bottler in the world. In 2010, Coca-Cola purchased their North American operations.
Chimera Investment Corp. (NYSE:CIM): Chimera is the third REIT on this list. They paid out $0.69/share in dividends, which would yield in the 15% range today. CEO Matthew Lambiase bought 50,000 shares on February 15 totaling $209,000. He's been making purchases like this for years and he currently owns 415,000 shares.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.


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Clinton Pushes Back Against GOP on Veterans' Health Issues
Clinton proposes improvements to veterans health care, services after her remarks criticized
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Explore Baby Bk 2 and more!
Baby Bk 2
Our life hack today is a perfect solution for calming your little one! Dr. Robert Hamilton, a pediatrician from Santa Monica, California is going to teach us an unusual trick on how to soothe a crying baby by using "The Hold" technique. This method has been used to quiet down babies during their visits to the clinic. See the video here: http://gwyl.io/this-doctors-hold-will-instantly-calm-your-infant/