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The People: Meet your makers
They may not quite be Gods, but on the Granite Belt we worship our makers anyway! The food and wine produced on the Granite Belt is lovingly made by real people. Whether it's a banker or lawyer who decided life in the slow lane was a better option, or a fifth generation farmer who diversified to save the family farm, each of our producers has a story to tell. What's more, they're happy to share it with you. Meet some of our makers ...
Ballandean Estate
Leeanne Gangemi and Robyn Henderson, daughters of the infamous Angelo Puglisi, are both passionate advocates of Ballandean. They spent their childhoods working with their parents in all aspects of the business and are happy to share their extensive knowledge of the history of the region with guests. Apart from being the pillars of the Granite Belt Wine industry, this family has donated a considerable amount to charitable causes through their annual events. See also winemaker Dylan Rhymer below.
Boireann Winery
Peter Stark is an ex-banker drawn to the region by the cool climates and opportunity to make great wine, a passion driven simply for the love of good red wine. While meticulous attention to the grapes may help explain why Boireann is now a favourite of James Halliday, it may be the Pink Floyd that Peter listens to while winemaking that makes all the difference!
Bungawarra Winery
Bungawarra Winery is one of the oldest vineyards around Stanthorpe (dating back more than 100 years) and was purchased by the Harden family in August 1993. A career change beckoned when pharmacist Jeff Harden seized his dream in 1993 when one of the region's oldest vineyards, Bungawarra Winery, came on the market. Bungawarra began as a dream and became the centre of Jeff's life. Apart from wine his other passion is literature, and the two come together each year around November when the "Shakespeare under the Stars" series takes place at the winery.
Casita de Campo
Meet Rudy Mazar from Casita de Campo and Westlake Studio who creates pottery and stone art work with local granite from his property.
Castle Glen Australia
Determined to create All Natural Preservative Free Wines, Cedric Millar, Castle Glen's Wine Maker, oversees all of the growing and production at Castle Glen Australia. The vines at Castle Glen Vineyard were planted in 1990 and Cedric has been making the wine with the many different varieties of grapes since the first harvest in 1994. Diversification came early, venturing into fruit wines and liqueurs made from fresh local produce. Traditional English Style Liqueurs and the 'World First' Crème Liqueurs have followed to become part of a range of 500 plus truly unique products including the "Pecan & Hazelnut Liqueur" which won a Gold Medal – Grand Champion Liqueur.
Granite Belt Brewery
Meet the Davenports. Geoff has always been very passionate about beer. He and his wife Dee lived in the UK for many years prior to having a family and trying new ales was always something they loved to do. Geoff's father, Mike was also a very keen home brewer and Geoff enjoyed helping him with his hobby. Before moving to the Granite Belt, Geoff Davenport was a business analyst in various locations including Brisbane, Canberra and the UK. They promptly decided on a tree change and purchased Happy Valley Retreat in 2009. When plans for Granite Belt Brewery were under way, Geoff flew to Western Australia and completed a brewing course at Edith Cowan University.
Dylan Rhymer
Winemaker Dylan Rhymer developed a passion for winemaking after participating in a wine appreciation course, which prompted a move to Hawkes Bay where he then became a "Flying Winemaker" following the vintages and wine seasons around the world before settling in the Granite Belt with wife Paola.
Stanthorpe Cheese
Meet Karen Deeth from Stanthorpe Cheese, who turned an overmilking mummy cow into the Granite Belt's first and only farmhouse dairy. She started making cheese in her home kitchen about 15 years ago when she had a Jersey x Freisian cow who gave her about 30 litres of milk every day, which was too much for her calf. So Karen got some books from the library and started experimenting with various cheese recipes.
Jim Barnes
Jim Barnes is perhaps one of the most respected winemakers in the region, always giving up his time to progress the industry or help out another winemaker. Perhaps his teaching background explains this. "After teaching for many years I turned to wine – who wouldn't?" he is quoted as saying. Along with fellow burly winemaker Peter McGlashen he instigated and brought to fruition the highly successful Granite Belt Strange Bird Alternative Wine Trail marketing concept.
Just Red Wines
Winemaking is very much a family business at Just Red Wines. Tony and son Michael have been making wines together since Michael was knee high to a grasshopper. Both are qualified winemakers and both have graduate diplomas in Viticulture and Oenology from Lincoln University in New Zealand. Their first vintage was back in New Zealand in 1993. After five vintages in New Zealand they 'saw the light' and came to the wonderful Granite Belt to set up Just Red Wines. They have now been making 'Just Red Wines' since 2003.
Pyramids Road Wines
Meet Sue & Warren Smith, owners of Pyramids Road Wines. What do you do when you want to live on a dirt road and are tired of your current teaching and house building jobs? You go back to University, sell your house and move to the Granite Belt to buy a property of course. Warren and Sue's passion for winemaking is not likely to be forgotten after a visit to their cellar door. And you certainly won't forget the beard!
Ridgemill Estate
Peter McGlashan is a testament to the saying "find something you love doing and you won't work another day of your life". Coming from a background in hospitality, he moved to the Granite Belt 17 years ago. During this time he has worked with two of the founding wine families of the region which only inspired him to make his own mark. Along with fellow local Jim Barnes, Peter's undeniable passion for the region saw them establish the Strange Bird Wine Trail which has now become a Granite Belt wine region icon.
Sutton's Juice Factory, Cidery & Shed Café
An ex fisherman, Dave Sutton bought his apple orchard in 1994, at a time when many were trying to get out of farming. When apple prices plummeted, he knew he would have to diversify and his first foray was into apple cider, followed by varietal apple juice, which he tested on customers at farmer's markets. Now producing award winning cider, apple juice and famous apple pies, the Sutton's are the epitome of honest growers who adapted to a new life in hospitality.
Lucas Estate
Louise Samuel considers herself to be the 'accidental winemaker' and is happy to explain that she does have an Honours Degree... but it has nothing to do with wine. Louise's husband, Col Sellers, was the one with the dream of making wine and Louise's painting ability fitted in with their joint dream of a winery with a cellar door and gallery. Sadly Colin died in 2008 and Louise was forced to carry on alone. Louise is a lady who does everything at full speed... has to as she covers everything from the vineyard to the marketing.
Mallow Lamb
Meet Andrew Ferrier who turned a disastrous drop in wool prices into award winning sustainable, and humane organic lamb production. Andrew spends the majority of his time now working the complete food chain – from breeding lambs, managing their health & welfare, fattening on organic high nutrient pasture to packaging and labelling the final product and selling to customers, outlets & restaurants in Brisbane, Sunshine Coast , Gold Coast and locally.
Symphony Hills Wines
Owner Ewen MacPherson is a perfectionist who turned his neurosis and viticulture studies into the production of ultra-premium quality wine that has since won numerous awards nationally.
Symphony Hills Wines
Symphony Hill's winemaker, Mike Hayes has worked in 16 regions, 4 states and 2 countries in the wine industry and has been involved with all aspects of production. If you're really lucky, you'll catch Mike harvesting some of his grapes in the nude during a full moon to revive an ancient winemaking ritual.
Twisted Gum Wines
Tim and Michelle Coelli's passion for both wine and sustainabale agriculture combine at their Eukey vineyard. Press Tim and Michelle for the secrets to the success of their sustainable vineyard practices, involving the use of birdlife to replace pesticides and careful mulching instead of irrigation.


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Best. Video. Ever. Millennials on the Sexual Objectification of Women
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The politically motivated, wrongful prosecution of Rick Renzi
New AG Sessions and Congress Must Investigate DOJ Corruption in the Case of Rep. Rick Renzi
Rick Renzi Puts Together Top Legal Team to Appeal Hidden Evidence of FBI Agent's Corruption
Judge Unbelievably Refuses to Grant a Retrial for Former Rep. Renzi Despite Finding Rampant Prosecutorial Wrongdoing
Bombshell: New Evidence Reveals Prosecutor Corruption in Trial Against Former Congressman Rick Renzi
Time For a Congressional Investigation: Shattering New Developments of Corruption in Rep. Renzi Trial
Judge Unravels Illegal Activity by Prosecution That Ensured a Conviction of Renzi — But Will he do Anything About it?
Former Congressman Renzi Deserves a New Trial
SCOTUS Turns Down Former Rep. Rick Renzi's Appeal of Legal Assault
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With a stay at Tamaris - Hotel Resort Drazica in Krk (Krk Island), you'll be minutes from Punta di Galetto Beach and Drazica Beach. This beach hotel is within close proximity of Frankopan Castle and Cathedral of the Assumption.
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This thread may be completely hormone driven but in a interest to divert from the normal topics around these parts I am interested in learning from other members here have to say about approaching women and what they feel is key for a woman to have before going after her. If the mods think this thread is inappropriate feel free to delete it. If any women on these forums feel offended feel free to make another thread for guys lol.
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12/15/09 at 10:46pm
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text: Home Shows & Schedule Unwrapped 21st Century Chocolate Unwrapped Hosted by Marc Summers Email MainEpisodesRecipesVideos (19) 21st Century Chocolate Today on Unwrapped, we're looking at companies who are putting new twists on a favorite dessert -- chocolate! First up, Malt-o-Meal is bringing dessert to the breakfast nook with their Chocolatey Mini Spooners, and at Max Brenner's chocolate restaurant, you can get the delicacy almost every way imaginable! Then, dip into the Mrs. Field's factory with their new chocolate-covered cookies, and watch how Simply Divine Brownies is using technology to make a personalized treat! Later, the mystery ingredient that makes P2C2 so good, and find out why Gifford's Chocolate Lovers Ice Cream was voted the world's best! (Episode: CW2106H) Previous Episode Munchy Crunchy Next Episode Tubular Treats


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Stickman Escape from Prison
by: Fabulous Best Gaming Studios • 3.8K
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by: Fabulous Best Gaming Studios • 3.8K
Play this super fun and addictive new stickman prison break game! This poor man is trapped in a small cell at jail. Is it possible to find a way out? Now he needs your help to design the route and road map to escape from the prison.
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Posts in category "Events! Celebs! And Chefs! Oh My!"
A Vegetarian's Mac & Cheese Fest
This past Saturday, the first official Mac & Cheese Fest in Chicago surely delivered for this vegetarian. I rolled out of there stuffed to the gills, barely coherent and yearning to pass out on my couch…..kinda like that uncomfortable and painfully stuffed feeling you have after Thanksgiving dinner. When I had bought my ticket, I... Read more »
Beer Pairing Tips from Stella Artois
Pancakes on Wheels? Babycakes, It's Chicago's Newest Food Truck!
Chef Takashi Yagihashi's Noodles are Made for Slurping
Iron Chef Cat Cora Serves Up a Derby Good Time in Louisville


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Levels of Serum Zinc in Children With Enterocolitis and Chronic Malabsorption Syndrome
Background: Serum zinc concentration is the most widely used marker of zinc status.
Methods: We used a spectrophotometric method with chromogen 4-(2-pyridylazo) resorcinol sodium salt to measure serum zinc concentrations.
Results: Zinc level in serum was measured in children with acute enterocolitis (AE)— 12.87±2.42 μmol/L, chronic malabsorption syndrome (MS)—8.59±2.30 μmol/L, and control groups of healthy children—18.90 ± 5.75 μmol/L. The zinc levels in children with AE and MS were significantly lower compared to those in healthy controls.
Conclusion: Serum zinc is a widely used clinical and laboratory indicator for assessment of low levels of zinc and zinc deficiency. With its good analytical parameters and accuracy, the applied spectophotometric method for measurement of serum zinc could be used for diagnosing of zinc deficiency. In the present study, it is applied for the first time in children with AE and MS.
- Copyright© by the American Society for Clinical Pathology (ASCP)


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improvements to outlook syncing over S4?
I came to samsung after a string of blackberries. What BB did very well, and what i miss, is reliable syncing to all aspects of Outlook. I'ts been a struggle with the S4 and i've had to pay for third party software but my contacts are still in a mess.
Does the S5 bring with it any improvements to syncing with outlook? (I guess the question applies to kies too).
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Plan To Discard Old Ships Ahead Of Schedule
News: A plan by the US Department of Transportation to remove old unwanted ships in the Bay Reserve Fleet in California is two years ahead of schedule, reports American Shipper. The Maritime Administration had announced plans in 2010 to remove 28 ships from the fleet by September 30. However, 36 ships from the fleet have been removed and three more are expected to be removed by end-2012. The Maritime Administration had revealed a plan in October 2009 to give contracts to prioritise the removal of the most hazardous ships from the bay and improve cleaning measures for the remaining. Out of 57 ships, 21 ships remain to be removed and the administration intends to remove all of them by October 2017. The Maritime Administration has sold 15 vessels for recycling in recent years.


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About The Right Coast
Hook-filled, punk-infused commercial pop outfit the Right Coast came together in 2008 as the antidote to the burgeoning Lancaster, PA-based hardcore scene. Formed around the talents of forename-loving locals Brandon (vocals), Doug (bass), Pat (guitar), Curran (drums), and Joe (guitar), the Right Coast quickly won regional favor with their This Is Now EP, an infectious, highly melodic collection of upbeat punk-pop in the vein of the Plain White T's and We the Kings. ~ James Christopher Monger, Rovi


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A Great Flaw in This Side of Paradise by F. Scott Fitzgerald
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Pages: 4
Word Count: 2,345
Category: English
Sub-Category: American Literature
Topic: F. Scott Fitzgerald
Word Count: 2,345
Pages: 4
Many critics have complained with justice that a great flaw in This Side of Paradise aside from its loose rambling structure is the fact that the author seems uncertain as to his own attitude He mocks the romantic delusions or emotional melodrama of his little rich boy Amory Blaine while too often he shares or seems to share in the delusions themselvesThere is in short a kind of smart pseudo-sophistication imbedded within the narrative itself-a series of clever comments inserted for the sake of the cleverness rather than for any aesthetic purpose And one result of this aesthetic self-indulgence is that the reader may find it difficult to take either Amory or his adventures with any degree of seriousness at all Indeed one feels as though the author himself were doing what Amory does during the course of the narrative he merely holds the posture of writing about what actually is a very slight matterThe need for some sort of imposing or melodramatic gesture is of course one of the chief qualities of Amory Blaine as an adolescent That neither Amory nor his creator-F Scott Fitzgerald-ever grew out of this need is a fact that readers of Fitzgeralds works have recognized as central to the direction of his life and career For Amory at any rate and for his mother Beatrice Blaine as well the posture of reality all too often replaces reality itself while gesture stands as a substitute for emotional commitmentA woman of inherited wealth Beatrice Blaine is a lovely charming superficial childlike woman who maintains the posture of romance a mere surface superimposed upon an essentially frigid or infantile refusal to commit herself to anything at all She is of course the prototype for what has come to be known as the Fitzgerald Woman - an enchanting but essentially parasitic femme fatale whom Fitzgerald the author used so often for his books and whom in the person of Zelda Fitzgerald the man
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|California Bans Use of Napa Brand Names on Non-Napa Wines
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Inexpensive Italian
Sandra is cooking up some Italian favorites with a price tag you're going to love, starting with savory Veal Osso Buco Stew with Spicy Polenta. Also on the menu, is a delicious and easy recipe for Crispy Eggplant Parmesan. Save room for dessert because Sandra's cooking up some sweet and crispy Italian Donuts With Cherry Sauce and for Cocktail Time, her Venice Sunset is on the horizon. Last but not least, Sandy has a terrific Round 2 Recipe for Osso Buco Calzones; it's big Italian flavor with a tiny price tag! (Episode: SM0303H)
VideosMore Sandra's Money Saving Meals Videos
Recipes from this episodeAll Sandra's Money Saving Meals Recipes
Osso Buco Stew with Spicy PolentaRecipe courtesy of Sandra Lee
Crispy Eggplant ParmesanRecipe courtesy of Sandra Lee
Italian Donuts with Cherry SauceRecipe courtesy of Sandra Lee
Venice Sunset CocktailRecipe courtesy of Sandra Lee
Round 2 Recipe - Veal Stuffed CalzoneRecipe courtesy of Sandra Lee
Online Round 2 Recipe - Crispy Eggplant and PastaRecipe courtesy of Sandra Lee


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Sammy Nestico and the SWR Big Band: Basie-cally Sammy
There are a number of old favorites hereclassic charts like "Sweet Georgia Brown, "88 Basie Street, "Fancy Pants, "Ja-Da, "The Heat's On, "Satin Doll, "It's a Wonderful World, "How Sweet It Is and "Wind Machine (the last a "bonus track recorded in concert)and several charming newcomers as well, most notably "Time Stream, "No More, "Li'l Ol' Blue Note, "High Five and "Ain't Nobody Gettin' Younger (even though, at age 81, Nestico doesn't appear to be gettin' any older either). The band gives each one an exhilarating ride, swinging like Basie while sounding like SWR.
The ensemble comes out smokin' on Nestico's "Dimensions in Blue, which I believe was written for the Airmen of Note (if memory serves, it may still be their theme song), and unleashes more of its awesome firepower on the voluptuous "Georgia Brown. After introducing "Georgia," pianist Klaus Wagenleiter, one of a bevy of impressive soloists, is featured on the ambling "88 Basie Street, alto Klaus Graf on "Samantha, tenor Axel Kühn on "No More and "The Heat's On. Trumpeter Don Rader, who has either relocated from Australia or was imported especially for this date, is the flugel soloist on "Satin Doll and is heard again, on trumpet, with Wagenleiter, bassist Decebal Badila, alto Steffen Weber and Kühn (flute) on "How Sweet. Others who step up to the plate and swing for the fences are trombonists Marc Godfroid, Ian Cumming and Ernst Hutter; trumpeters Karl Farrent and Claus Reichstaller; tenor Andi Maile; baritone Pierre Paquette; guitarist Klaus-Peter Schöpfer, and drummer Holger Nell. Schöpfer fills rhythm guitarist Freddie Green's shoes nicely, while Nell has no problem sitting in for Sonny Payne, Butch Miles and Basie's other renowned timekeepers.
This is a dynamic blowing session, one you don't have to love Basie to appreciate. And when Sammy says he hasn't "had this much fun in years, it's a clear indication of his happiness with SWR's respect for his music, not to mention the ensemble's remarkable ability to transcribe it. This is "basie-cally big band jazz with an unequivocal kick, precisely the kind that the irrepressible Kid from Red Bank gave free rein to and ardently endorsed.
Track Listing: Dimensions in Blue; Sweet Georgia Brown; 88 Basie Street; Fancy Pants; Time Stream; No More; Li�l Ol� Blue Note; High Five; Ja-Da; The Heat�s On; Samantha; Ain�t Nobody Gettin� Younger; Satin Doll; It�s a Wonderful World; How Sweet It Is; Wind Machine (74:53).
Personnel: Sammy Nestico: music director; Felice Civitreale, Claus Reichstaller, Karl Farrent, Rudolf Reindl, Don Rader: trumpet; Klaus Graf: alto sax, clarinet, flute; Steffen Weber: alto sax, flute, alto flute; Axel K�hn, Andreas Maile: tenor sax, flute, alto flute; Pierre Paquette: baritone sax; Marc Godfroid, Ernst Hutter, Ian Cumming, Georg Maus: trombone; Klaus- Peter Sch�pfer: guitar; Klaus Wagenleiter: piano; Decebal Badila: bass; Holger Nell: drums.
About Sammy Nestico
New York Beat
CD/LP/Track Review
- Fun Time and More Live by C. Michael Bailey
- Basie-cally Sammy by Jack Bowers
Extended Analysis
CD/LP/Track Review
- This Is the Moment by Jack Bowers
Gordon Goodwin's Big Phat Band-hamilton & Hamilton-shelly Berg Trio- Alan Bergman
Newport Beach Marriott Hotel & Spa
Newport Beach, CA
|7:00 pm


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UFC 117 | The Spider Pulled Off a Major Comeback Victory!Category: MMA
Chael Sonnen almost pulled off a Frankie Edgar.
For four rounds, the trash-talking Sonnen backed-up his words when he dominated the 'invincible' Anderson Silva.
Going into the fifth and final round, Sonnen is almost destined to make a major upset (see Edgar vs Penn), leading on all the judges' scorecards, BIG.
However with 1:50 remaining in the bout, Silva wrapped his long legs around Sonnen's neck and caught him with a triangle choke to pull off one of the most improbable come-from-behind victory in UFC history.
It was the first time a champion had ever lost four straight rounds and came back to win in the fifth. This was also one of only three fights in UFC history to end in the fifth round.
For the ninth time in his career, Sonnen have not managed to escape a submission hold.
Prior to this fight, UFC President Dana White threatened to cut "The Spider" from the UFC if he don't make his act straight.
His performances at UFC 90, UFC 97 and UFC 112 were more like clowning than fighting that's why he was given the ultimatum.
After the fight, White said:
"This was a legendary fight tonight. This is one of those fights where Anderson Silva went up a notch."
In a packed fight card, it was awarded as "Fight of the Night". Heck, it might as well be the "Fight of the Year".
It also saved Anderson Silva's UFC career, his UFC Middleweight title and extended his record streak of most consecutive wins in the UFC to 12 and most successful title defenses to seven.
Check out the Anderson Silva vs Chael Sonnen fight video.
UPDATE December 2, 2010: The Silva vs Sonnen fight was named the World Mixed Martial Arts Awards 2010 Fight of the Year!If you want to receive my latest posts, please subscribe to my full feed RSS or have them delivered through email. Just enter your email address below and hit the Subscribe button.
Tags: anderson silva, chael sonnen, UFC 117
6 Responses to "UFC 117 | The Spider Pulled Off a Major Comeback Victory!"
Winziph Says:
August 8th, 2010 at 10:37 pm
silva just prove that he deserves to be in UFC.
dirty dude Says:
August 9th, 2010 at 11:30 am
damn, i thought we have a new champ.
nicko Says:
August 10th, 2010 at 4:49 am
It was a pretty good fight. I don't think Silva was fighting at his best.
melardenio Says:
August 13th, 2010 at 8:27 am
Might be luck…
ayaw ko pa din manuod nyan hehehhehe
jay Says:
October 21st, 2010 at 11:10 pm
he planed it all he knew what he was doing
just didnt want to get cut from the UFC


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Palatin Technologies, Inc. (NYSEMKT:PTN)
F4Q12 Earnings Call
September 11, 2012 11:00 a.m. ET
Carl Spana - President and Chief Executive Officer
Steve Wills - Chief Financial and Operating Officer, Executive Vice President
Jeffrey Edelson - Chief Medical Officer
Joseph Pantginis - Roth Capital Partners
Rahul Jasuja - Noble Financial Capital Markets
Good morning, ladies and gentlemen, and welcome to the Palatin Technologies Fourth Quarter Fiscal Year End for 2012 Call. As a reminder, this call is being recorded.
Before we begin our remarks, I would like to remind you that statements by Palatin that are not historical facts may be forward-looking statements. These statements are based on assumptions that may or may not prove to be accurate and the actual results could differ materially from those anticipated due to a variety of risks and uncertainties discussed in the company's most recent filings with the Securities and Exchange Commission. Please consider such risks and uncertainties carefully in evaluating these forward-looking statements and Palatin's prospects.
Now I would like to introduce your host for today's call, Dr. Carl Spana, President and Chief Executive Officer of Palatin Technologies. Please go ahead, sir.
Carl Spana
Thank you. Good morning. I'm Carl Spana, President and CEO of Palatin Technologies. With me on the call today is Steve Wills, our Chief Financial and Operating Officer, and Executive Vice President; and Dr. Jeffrey Edelson, our Chief Medical Officer.
On today's call we will be providing updates on our product programs and financial results. To begin, Steve Wills will provide an update on our fiscal fourth quarter 2012 financial results. Steve?
Steve Wills
Thank you, Carl, and good morning everyone. Regarding our financial operating results, Palatin's net loss for the quarter ended June 30, 2012 was $5.3 million or $0.14 per basic and diluted share compared to a net loss of $3.3 million or $0.09 per basic and diluted share for the quarter ended June 30, 2011.
For the year ended June 30, 2012, we reported a net loss of $17.3 million or $0.49 per basic and diluted share compared to a net loss of $12.8 million or $0.64 per basic and diluted share for the year ended June 30, 2011. The change in net loss for the quarter and year ended June 30, 2012 compared to the net loss for the same period of last fiscal year, was primarily the result of costs related to our ongoing Phase 2B clinical trial with bremelanotide for female sexual dysfunction.
In addition, in the quarter ended June 30, 2011, Palatin recognized $1.3 million of non-cash, non-operating income related to our March 2011 public offering, which represented the change to the warrant liability accounting.
Regarding revenue, total revenue for the quarter ended June 30, 2012 which consisted entirely of amounts recognized under our obesity collaboration with AstraZeneca, was $11,000 compared to $155,000 for the quarter ended June 30, 2011. Revenue for the quarter ended June 30, 2011 consisted mainly of grant revenue pursuant to the Patient Protection and Affordable Care Act of 2010, commonly referred to as Section 48D, and also amounts recognized from AstraZeneca.
Total revenues for the year ended June 30, 2012 were $74,000 and consisted entirely of amounts recognized from our collaboration with AstraZeneca. Total revenues for the year ended June 30, 2011 were $1.5 million and consisted of $1 million of grant revenue pursuant to Section 48D, and the remainder from AstraZeneca.
Regarding cost and expenses, total operating cost for the quarter ended June 30, 2012 were $5.7 million compared to $4.7 million for the same period in 2011. Staying on cost and expenses, for the year ended June 30, 2012, total operating expenses were $18.9 million compared to $15.1 million for the year ended June 30, 2011. The increase in costs for the quarter and year ended June 30, 2012 compared to the quarter and year-end June 30, 2011, is a result of cost related to our FSD trial with bremelanotide which is currently in Phase 2B.
Regarding our cash position, as of June 30, 2012, our cash and cash equivalents were $3.8 million and we have current liabilities of $3.5 million. This compared to cash and cash equivalents of $18.9 million and current liabilities of $2.8 million as of June 30, 2011. In July 2012, Palatin closed on a $35 million private placement with the net proceeds after deducting operating expenses, amounting to $34.5 million.
Palatin's audited financial statements for the year ended June 30, 2012, included in our Annual Report on Form 10-K, includes an audit opinion that contains a growing concern explanatory paragraph from our auditors KPMG related to certain redemption rights for Series B 2012 warrants issued in our July 2012 private placement in the event that stockholders do not approve an increase in authorized shares of common stock by a specific period. Carl?
Carl Spana
Thank you, Steve. And now for an update of our programs, starting with our obesity and diabetes melanocortin-4 receptor program which is partnered with AstraZeneca. This program is run under the direction of AstraZeneca. As we have previously reported, AstraZeneca has discontinued development of the clinical candidate AZD2820. This decision was based on a single severe adverse event experienced by an obese patient in a Phase I trial of AZD2820. AstraZeneca has competed an investigation of this severe adverse event and it appears that this severe adverse event was not cardiovascular related, and while not confirmed, it could not be excluded that the severe adverse event was linked to AZD2820.
The investigation further concluded that the severe adverse event did not appear did not appear to be related to the melanocortin mechanism of action. Although the discontinuation of AZD2820 is disappointing, AstraZeneca and Palatin remain committed to the development of the melanocortin-4 receptor agonist for the treatment of obesity. Because of the comprehensive nature of the collaboration, we are fortunate to have multiple classes of backup collaboration compounds in various stages of pre-clinical development.
AstraZeneca has informed us that they remain committed to the continued advancement of collaboration compounds for the treatment of obesity. Based on our discussions with AstraZeneca, it is our expectation that one or more collaboration compounds will move forward to complete pre-clinical testing and enter into clinical development.
Results and proof of principle clinical trials in obese patients with non-commercial compounds that target the melanocortin-4 receptor, showed significant reductions in food intake and weight loss. We believe this clinical data along with earlier work on animal models of obesity demonstrate the significant role that the melanocortin pathway plays in regulating food intake, weight loss, and validates melanocortin-4 receptor as a major target for obesity therapeutics. We believe that therapeutics that target the melanocortin-4 receptor have the potential to dramatically impact the treatment of obesity. As you can imagine, this program has huge commercial potential and we believe that our partner, AstraZeneca, has the resources and commitment to realize this potential.
As we go forward, we're eligible for milestone payments totaling up to $145 million, with up to $85 million contingent upon development of regulatory milestones and the balance on achievement of sales targets plus mid-single to high-single digit royalties on the sales of approved products. AstraZeneca has responsibility for product commercialization, product discovery and development costs.
As we move on, as mentioned by Steve, we concluded a $35 million financing in July of this year. Part of the proceeds from this financing was earmarked to support the progression of our melanocortin receptor and natriuretic peptide programs. One of the areas that we have focused our research efforts is the design and development of compounds that affect the natriuretic peptide system.
The natriuretic peptide system has numerous cardiovascular and pulmonary functions and therapeutic agents modulating this system may be useful in the treatment of pulmonary diseases such as asthma, heart failure and hypertension. Research work at Palatin has generated an extensive library of compounds active at the various natriuretic peptide receptors.
Our clinical candidate, PL-3994, is a selective natriuretic peptide receptor agonist. PL-3994 is a synthetic molecule incorporating a novel and proprietary amino acid mimetic structure and has an extended biological half life when compared to the indigenous hormone, Atrial natriuretic peptide. PL-3994 is in development for treatment of acute exacerbations of asthma, and may have additional utility as a treatment for heart failure and refractory hypertension.
We have conducted two Phase I clinical studies with PL-3994 designed to evaluate the safety and pharmacology of the compound. In these studies, PL-3994 demonstrated the pharmacology expected of a natriuretic peptide receptor agonist, and a safety profile that supports continued development. The lead therapeutic indication for PL-3994 is the treatment for acute exacerbation of asthma, which is defined as an ongoing asthma episode in which asthma symptoms do not adequately respond to initial bronchodilator or corticosteroid therapy. Some patients with acute exacerbations of asthma becomes unresponsive to beta 2 (inaudible) receptor agonist, significant limiting treatment options and increase risk. Patients who do not respond to initial therapy are at risk of severe complications.
We intend to initially target PL-3994 as a treatment for those at-risk, unresponsive patients. As we have previously stated, a key near term objective of our PL-3994 program is to identify a development and marketing partner. To support our business development efforts we have initiated a series of preclinical studies designed to provide additional data that supports the use of PL-3994 as a treatment for asthma. We have also initiated the pre-clinical [tox] studies required to support a nebulized formulation of PL-3994, for inhaled delivery of PL-3994.
I would now like to cover another research areas of interest at Palatin, the melanocortin receptor system. The melanocortin system is involved in a large and diverse number of physiological functions. And therapeutic agents modulating this system may have the potential to treat a variety of conditions and diseases including sexual dysfunction, obesity and related disorders, pigmentation disorders and inflammation related diseases.
Palatin has a long standing research effort in the design and development of therapeutics that affect the melanocortin receptor system. These efforts has resulted in the compound bremelanotide, currently in development as a treatment for female sexual dysfunction, which we are going to talk about in a minute. And the melanocortin-4 receptor selective compounds that are the basis of our obesity and diabetes collaboration with AstraZeneca.
So in addition to these two exciting programs which target the melanocortin-4 receptor, we have accelerated our efforts to bring forward compounds that work through activation of the melanocortin-1 receptor. We are conducting preclinical studies to finalize selection of a number of lead compounds for development as treatment for immune modulation, inflammatory and skin pigmentation diseases. There has been substantial interest in our melanocortin-1 receptor research work and we have begun discussions with potential partners interested in licensing programs in the melanocortin-1 receptor area.
Finally, I will cover our female sexual dysfunction program. Bremelanotide is a melanocortin-4 receptor agonist in development as a treatment for female sexual dysfunction and it is our lead clinical program. Bremelanotide is currently being studied in a Phase 2B clinical trial designed to evaluate its safety and efficacy as a treatment for pre-menopausal women with female sexual dysfunction. We are happy to report that the last patient has completed the study and we anticipate the results from this study early in the fourth quarter of this calendar year.
As a reminder, the main objectives of this trial are to generate the safety and efficacy data to support the transition of this program into Phase 3 registration trials. The trial was designed as a placebo-controlled double-blind study. The study has four parallel arms, one placebo and three bremelanotide doses. This study uses multiple end points to measure the effects of bremelanotide on improving the symptoms of female sexual dysfunction. These include improvement in the number of satisfying sexual events as measured by a validated event log or diary, and changes in arousal, desire and sexual dysfunction associated distress as measured using validated patient self-assessment questionnaires.
We will also evaluate the blood pressure effects of subcutaneously administered bremelanotide in this patient population as well. We believe we have designed a comprehensive program to evaluate the safety and efficacy of bremelanotide and if the results of this study are positive they will support the transition of this program in to Phase 3 registration trials. We believe that our bremelanotide female sexual dysfunction program has tremendous potential. There was no FDA approved treatment for female sexual dysfunction and these patients have limited treatment options. We also believe that this area represents a significant area of unmet medical need and substantial commercial opportunity.
So before we open to questions, our efficacy program is on track to deliver data early next quarter for a major Phase 2B clinical study designed to provide the safety and efficacy data to move into Phase 3 registration trials. We were able to secure a substantial $35 million financing to provide the financial resources required to advance our programs. Our PL-3994 program for severe asthma is ready to begin a proof of principle clinical trial. And we have initiated pre-clinical activities on a number of melanocortin-1 receptor programs and our discussions with our potential partners.
Finally, our obesity and diabetes program partnered with AstraZeneca had a setback with the discontinuation of AZD2820, however we remain quite excited by the potential of the melanocortin-4 receptor agonist and a treatment for obesity and will be supporting AstraZeneca's efforts to move a new clinical candidate into development.
In closing, I would like to thank you all for participating on the Palatin conference call, and we are now going to open the call to questions.
Question-and-Answer Session
(Operator Instructions) And we will hear first from Joe Pantginis with Roth Capital Partners.
Joseph Pantginis - Roth Capital Partners
Good morning. Thanks for taking the question. Couple of questions if you don't mind. Let's start with the lead program. With FSD, when you do have the data to present, what will you be presenting? Obviously, you know the top line primary end point but you do have a lot of endpoints that you are looking at. So I wanted to get a sense of what we could expect on the street.
Carl Spana
We are going to try and present as comprehensive a picture as we can. There are multiple endpoints in this study. As we said, satisfying sexual events, there are patient reported outcome measures that -- such as the female sexual function index that measured changes in arousal and desire. So we will have that data. And then the important third measure that we have is another a (inaudible) that's called female sexual dysfunction scale. And that also will have data that we will read out as well.
So we are not going to just say we hit a primary end point in that set. We will give a fairly comprehensive look at the endpoints that we believe are required to move forward into Phase 3, and as well as a good look of the safety of the drug, how it's performed in this particular population in the study.
Joseph Pantginis - Roth Capital Partners
Well, that's great. And then if you sort of translate to that with your recent raise, you do have a decent amount of money to move into Phase 3. How quickly do you think you would be able to move into Phase 3 and would the design sort of mimic your current Phase 2B or how should we look at that?
Carl Spana
You know, the data coming in, as I said in the October timeframe, so by the time we get full data sets in, move forward to end of Phase 2 meeting, we really are targeting second half 2013 to move into Phase 3 trials. I mean we have a lot of activities that have to be done. Such as the end of Phase 2 meeting, setting up the full trials and then going forward from there. In addition, we also want to allow a little bit of time for potential partnership discussions to play out as well. As we expect we will be having substantial interest in the project.
Joseph Pantginis - Roth Capital Partners
Sure. No, absolutely. And then just switching real quickly over to AstraZeneca. Beyond 2820, obviously you have made a big point though obviously that AstraZeneca still remains committed. They are working on other development compounds. Maybe you could provide a little more color with regard to the stage of those compounds and when we could see some potential news out of those programs.
Carl Spana
Sure. I mean I am going to be a little bit restricted here because of, obviously competitive issues and confidentiality concerns on the part of AstraZeneca. But you know the programs they run really -- when we say preclinical, they really run from compounds that are just discovered to compounds that have gone through tox evaluation. So they really approach this with a lot of resources. So it really runs the gamut from close to being able to go into clinic to or [lay] back to vey early.
News flow from here, again, what we can't say is having looked at where they are and what's going on, is we are pretty excited about what they have. I think that they really believe this is a key program and that they have a proprietary position. We will battle within as much as we can to be able to disclose as much as we can, as quickly as we can to the Street. But it's going to be a battle because they do believe this is a validated mechanism and that they have the answer to solving obesity with this mechanism. And they [really] have a [partner] position. So as quickly as we can we will get it out there but, as I said, they go anywhere from readily going to humans to further back.
We will take our next question from Rahul Jasuja with Noble Financial Capital Markets.
Rahul Jasuja - Noble Financial Capital Markets
Just wanted to go through basically most of the leading programs. Let me start with FSD. So you did talk a little bit about that and the endpoints and so on, but could you -- what's a successful trial? What do you want to tell the Street that will comfort us going into a pivotal study? And then obviously there is, I guess, a lack of experience in understanding FSD from the Street's point of view. There hasn't been a lot of drugs in that path. We have had (inaudible) with its use, but what is interesting is a couple of months ago, Sprout reviving Boehringer Ingelheim's FSD drug and forming a new company around it. So obviously there is huge need there. Could you just comment on those aspects?
Carl Spana
Sure. A couple of things here. Let's start from the basics. There have been two ways of measuring efficacy in this indication. And one has been satisfying sexual events which is a very simple counting mechanism. And patients takes the drug or is on the drug that have a sexual encounter and very simple yes or not, was it satisfying. And you count it on a screening period of a base line period and you compare to a period at the end of the study, subtracting, you have got an answer.
You know it's somewhat of a controversial endpoint and has posed problems for a number of sponsors. The other way of measuring efficacy is using patient reported outcome measures which take a more global look at changes in desire, arousal and distress associated with your sexual dysfunction. And those endpoints tend to probably be tracked with the disease and tend to be probably more relevant to the patient in satisfying sexual events.
And what's happening, from what we can tell from our discussions with people and thought leaders, we are aware of Sprout. As you can imagine we try to do the best in competitive intelligence that we can, the endpoints are changing a little bit here. It's not clear what Sprout will present to the FDA as the key endpoints for flibanserin. There will be some mixture of patient [supported] outcome measures like the female sexual function index as well as satisfying sexual events. The question is order, which will be primary and which will be secondary. And that's really what is up for discussion.
The two things that I feel, and we think we believe very strongly on that are very important really, are results on the female sexual function index and then on the female sexual distress scale. Those are the key elements of the diagnosis and they are key elements that need to be improved for the patient to feel that they have gotten better. That's not to diminish satisfying sexual events, it's a key endpoint we well, but it probably doesn't track as well with the disease and is probably not as well related. And trying to read the tea leaves is, I think is going to be some flexibility on which of those are primary endpoints in Phase 3. So we are really looking to hit all of them but clearly we want to hit FSFI and FSDS and have a successful study.
Rahul Jasuja - Noble Financial Capital Markets
And Carl, you know the FDA really hasn't weighed in with a guidance document of late on FSD, have they?
Carl Spana
Well, actually the pulled the typed guidance document that they had out and I think what they are looking for are for responses to come in with well designed Phase 2 programs that have the data that validates why the endpoints you propose for Phase 3 are the ones that are meaningful to the patient and should be there. And that's what our study is designed to do.
We are looking at three types of endpoints here and the ones that are successful or most relevant to the patients are the ones that we will propose to go forward within the Phase 3. And we will be in the fortunate position to actually have real Phase 2B data from a decent sized study that's supports the selection of those endpoints. And that's a little bit different then other sponsors have been
Rahul Jasuja - Noble Financial Capital Markets
All right, thanks. Let me move on to couple of questions on obesity. You know we have that [assay] in that one patient and it was potentially the highest dose. And the healthy volunteers were given that particular dose or higher and there wasn't an issue. Could you talk to us about, is this AstraZeneca being really conservative, and they probably should do that, but was it a patient specific event, was it a highly compromised patient? It wasn't an allergic or immune response, it was probably something else. Could you just add to that?
Carl Spana
Sure. Again, a couple of caveats here. We didn't run the study. It's not in our direction. This is under the direction of AstraZeneca and we have to observe their confidentiality. And again, we weren't directly involved in working with the site that ran the trial, or handling the SAE or in that nature. So we have been in discussions with AstraZeneca. What we can say is it was not a cardiovascular event. It was temporary related to the administration of AZD 2820 but it couldn't be definitively said that it was related to the drug or not. And they made their decision. What's important for us is that it wasn't cardiovascular related and not related to the mechanism of action. I think those are the two key things followed up with the fact that we have a number of great compounds behind that that can go into development quickly. And really we will have to leave it at that because anything past that really becomes speculation.
Rahul Jasuja - Noble Financial Capital Markets
All right. Then finally on to preclinical program. The MCR [pathway] you just alluded to, that seems interesting. What is the -- so you have got cash now, what are the plans in terms of propagating the preclinical programs. And where do you see the path for MCR-1, or is it just MCR-1 or is it MCR-2 as well in looking at future therapeutic areas?
Carl Spana
Well, certainly MCR-2 is the ACDH receptor and it's not been an area for interest for us. We have done a lot of work here that we have not talked a lot about because we have had programs that were in the clinical. In the melanocortin-1 receptor area, and we believe that those compounds are quite interesting. The science behind them has been growing over the last several years, evidenced by the fact that there are now several MCR-1 compounds actually in clinical development for various indications. There is an IBD drug getting ready to enter phase 2 from a Japanese company, and then Abbott bought a mixed MCR-1 receptor for protection of renal damage from ischemic disease earlier this year. So it is an area that is heating up and there is lot of corporate interest.
So we would find ourselves in a very fortuitous position in that we have a comprehensive library of compounds. We have got good pharmacology, good activity in a number of systems and the resources to put to work to bring them forward. And on top of that we have quite a lot of corporate interest. So I we think we can bring a partner in as well to help. So you will see us moving really in the immune modulatory and anti-inflammatory indications with compounds. And as we generate more preclinical data and we make decisions to go forward, we will inform the Street and get strong clarity as to what programs we think are the most promising.
Ladies and gentlemen, that is all the time we have for questions. I would now like to turn the call back over to Dr. Spana for any additional or closing remarks.
Carl Spana
I would like to thank everyone for participating on our year-end conference call. Also thank the questioners, there were some very good questions. And with that I would like to say have a great day and we look forward to keeping you informed of our progress and certainly we are looking forward to our upcoming data. We are quite excited here and we think we have a great product in bremelanotide and a number of interesting programs behind that. And I would say we are excited and we are looking forward to data and getting it out to you as soon as we can. So have a great day and talk to you as soon as we have data.
Again, thank you ladies and gentlemen. That does conclude today's presentation. You may now disconnect.
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Babolat E-Sense Tennis Racquet - Grip 3ESCB3 3324921235394
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Improve your precision with the assistance of the Babolat E-Sense Tennis Racquet.
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Shipping & Delivery OptionsShipping options for [zipcode] (change)
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7 Daffodil Drive UNIT 39,Loudon NH, 03307
2 beds , 1 Full/1 Three-Qtr baths
1,520 sq. ft
Status: Active
Berkshire Hathaway HomeServices Verani Realty
(888) 723-0306
Listing Provided Courtesy Of: East Coast Communities Realty Group, LLC - Tony Marcotte
Last Updated: 1/23/2017 10:11 AM
Description for 7 Daffodil Drive UNIT 39 Loudon, NH 03307
Welcome to the Villages at Loudon, New Hampshire's premier active residential community. The Villages at Loudon is situated on 80 acres just East of Concord. This style home is the Villager featuring single story open concept living with the option to finish the walkout basement. The house is currently framed, roofed and sided. A sunroom has been added which is reflected in the listing price. The home can be custom finished with your choice of floors, kitchens and appliances. Finish the walkout basement for even more space.The Villages at Loudon also features a 2,500 SF clubhouse with fitness room, an outdoor recreation area, storage area for your mobile homes, boats and more. Other distinct home styles starting from $259,900.
Listing Information
Villages At Loudon
Community Water
Private Sewer System, Septic
200 Amps, Propane, Cable TV, Underground
Room Information
Kitchen, Living Room
First Floor Bedroom, Master Bathroom, Master Suite
1st Floor Bath
Interior Features
1,520 Sq. Ft. Above Ground
Dishwasher, Microwave, Electric Range/Cooktop, Refrigerator
Central Air, A/C - Zone
Gas Heat, Forced Air, Zone
Walkout, Full, Unfinished Basement, Entrance Inside
Security System, Alarm -Smoke/Fire
Smoke Alarm, Walk-in Closets
Exterior / Lot Features
2 Garage Spaces, Attached Garage, Paved Driveway, RV Parking
Deck, Patio, Porch Covered
Sprinkler System
Composition Shingle, Asphalt Shingle
Water Access, River, Landscaped, Rural, Community Maintenance, Paved Road, Private Roads, Additional land available, Wooded
Financial Considerations
Inside AccessTM
Current market conditions for 7 Daffodil Drive UNIT 39
Active Market Trends
Source:MLS DATA
Median list price$284,700
Days on market132
Properties for sale26
Sold Market Trends
Source:MLS DATA
Median sold price$241,000
Sales to list price10,167.0%
Properties sold28
Median sq ft price$128
Arrows indicate 90 day trend
Listing Price History for 7 Daffodil Drive UNIT 39
Loudon Real Estate
Loudon is located in New Hampshire. Loudon, New Hampshire 03307 has a population of 5,982.
The median household income in Loudon, New Hampshire 03307 is $81,356. The median household income for the surrounding county is $65,487 compared to the national median of $53,046. The median age of people living in Loudon 03307 is 45.8 years.
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Las Casas de los Mercaderes: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Seville, Spain.
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Availability and Prices
Booking Site
Room Type
Per room
Per night
Per night
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