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Hotels in Berlin
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Trending now in Berlin
- Most bookedPark Inn by Radisson Berlin Alexanderplatz
771 people looked at this hotel in the last hour
Most recent review
"Park Inn is very convenient for bus/trains, including hop on/hop off tour buses. Ate breakfast at Burger King in same building. Only negative was WiFi was extra charge and was too weak to send a FaceBook message with 12 photos. But definitely would stay there again for convenience to Christmas ma..."
A Traveller, Dec 2016, US
643 people looked at this hotel in the last hour
Most recent review
"The hotel is just next to the Berlin hfb station so travelling around the city is so easy and the hotel also gives you a free travel pass for all public transport which saves money. The hotel reception staff are very helpful and friendly. I would definitely stay again."
A Traveller, Dec 2016, GB
603 people looked at this hotel in the last hour
Most recent review
"Great location especially when you are moving around the city. Very close to the rail road hub. Everything was good except the hot water which unfortunately was available only at not peak hours. "
M, Dec 2016, US
555 people looked at this hotel in the last hour
Most recent review
"Check-in was a little slow because the reception area is quite small for the size of the hotel. However, once checked-in we found he room to be very spacious, modern, and comfortable. The hotel is a 5 minute walk to a major transit hub, bars/restaurants, and nightlife. The majority of the hist..."
A Traveller, Dec 2016, US
421 people looked at this hotel in the last hour
Most recent review
"A fabulous hotel with an amazing inward facing view. The room itself was clean and very comfortable. The staff were very helpful and the room service was quick and easy."
A Traveller, Dec 2016, GB
351 people looked at this hotel in the last hour
Most recent review
"Quick check-in by very pleasant and personable staff who spoke very good English. Hotel was exceptionally clean and room was more than adequate for a 4 day stay. Breakfast offered a good selection - hot and cold - in well laid out restaurant, and although it did get extremely busy on Saturday mor..."
A Traveller, Dec 2016, GB
324 people looked at this hotel in the last hour
Most recent review
"We had a fabulous long weekend with marvellous weather. The location of the hotel is fantastic for sightseeing . The beer garden adjacent to the hotel is just buzzing and food quite good there also. Staff in hotel were very friendly and helpful. It was a bit of a scramble for breakfast as the..."
A Traveller, Dec 2016, IE
311 people looked at this hotel in the last hour
Most recent review
"A well located hotel, with comfortable beds, nice rooms and a swimming pool and spa. The hotel is being renovated and the main entrance was out of use. The concierge was helpful and they could book trips and advice on how to fill your day. The hotel is about 5 minutes walk from the Zoogarten stat..."
A Traveller, Dec 2016, GB
298 people looked at this hotel in the last hour
Most recent review
"the hotel is a really smart hotel, near the station and right opposite the tram, and the staff were very helpful. the breakfast was nice and plenty of selection. and the bar on the 14th floor was nice."
A Traveller, Dec 2016, GB
214 people looked at this hotel in the last hour
Most recent review
"I was originally put in a room where there was someone, already. They tried to make up for that huge error by putting me in a bigger room. Hotel styled Swedish/Scandinavian flavor. Staff seemed to always have a hard time doing much of anything on their computers. Everything took forever in ..."
A Traveller, Nov 2016, US
Best Berlin Hotels
Things to see
A sprawling public square, Alexanderplatz is one of the busiest hubs within the central Mitte district – it's where you'll find the unique World Time Clock, a curious cylinder topped with an intricate sculpture of an atom. Nearby is the Fernsehturm, or TV tower, which reaches almost 400 meters into the sky and affords visitors jaw-dropping views across Germany's capital. As well as gazing out from the observation deck, you can also relax in the bar and restaurant. For world-class shopping, take a stroll down the Kurfuerstendamm, or Ku'damm as locals call it. This long and handsome boulevard is lined with independent boutiques, bars, and cafes, and is a must-see for any visitor. The Brandenburg Gate, meanwhile, is to Berlin what the Eiffel Tower is to Paris. A symbol of the city since the 18th Century, its vast columns and proud chariot sculpture have been a focal point for rallies and historic speeches for generations. Want to enjoy some drinks after a day's sightseeing? Stroll over to Hackescher Markt, one of the city's bohemian districts famed for its relaxed and colorful nightlife.
Hotels in Berlin
As one of Europe's major capital cities, Berlin has hotels for every kind of traveler. There are plenty of high-end establishments offering indoor swimming pools, luxuriant spas, and massage treatments, and rooms fitted with sumptuous Egyptian sheets and antique furnishings. Equally, you can find quirky boutique hotels in Berlin done up in a more minimalist, Bauhaus-inspired style, as well as good, reliable cheap chains that will do the job if your priority is to work or sightsee, rather than spend time in the hotel itself.
Where to stay
For tourists and business travelers alike, the Mitte district is an ideal place to stay. It's the very heart of the city, offering swift access to office complexes and top attractions like the city's many museums clustered on the aptly-named Museum Island. Alternatively you can choose to book your Berlin hotel in the Charlottenburg district. This is best known for the handsome Baroque and Rococo sprawl of Charlottenburg Palace, which is well worth a visit if you're in the area (or even if you're not). Another enjoyable district is Prenzlauer Berg, which is a real social hotspot with enough pubs, restaurants, and galleries to keep you occupied for days.
How to get to
Flying into Berlin? You may land at Tegel Airport, which is the largest hub for international travel in the area and is well located for the city – a taxi or bus ride will get you into the thick of things in no time. Budget airlines fly into Schoenefeld Airport, which is situated a bit further away from the city, while trains from every corner of Europe come into Berlin Central Station. A futuristic marvel of glass and steel, it's an attraction in itself.
When are the best times to travel to Berlin?Berlin is a fascinating city to explore at any time of year, but the summer months of June to August are undoubtedly the most popular. This is when you can swim in spectacular riverside pools, enjoy eating on sun-dappled terraces, and party all weekend at hip makeshift beach bars. December is another highlight, when magical Christmas markets pop up all over the city, and smells of spiced Glühwein and gingerbread fill the air. Late winter is your best bet for Berlin hotel deals, just be prepared to wrap up warm.
What are the top must-see attractions in Berlin?Berlin's most recognizable sight is the Brandenburg Gate – an elegant Neo Classical monument modeled on the gateway to the Acropolis in Athens, and commissioned by Friedrich Wilhelm II in the late 18th century. The city's skyline is utterly dominated by the Fernsehturm, or TV Tower. Built in the 1960s by the German Democratic Republic, this needle-like tower remains one of Europe's tallest structures. The East Side Gallery, meanwhile, is a 1.3 km stretch of the Berlin Wall, which has been covered with vibrant murals and repurposed as a moving monument to freedom.
What are the best types of food and restaurants in Berlin?As a thrillingly multicultural city, Berlin's food scene is constantly evolving, and every area has something unique to offer. In Kreuzberg you'll find eclectic street food markets, edgy pop-up restaurants, and mouth-watering authentic Turkish fare. Head to Mitte if you feel like splurging on a Michelin-star meal, or sampling upscale twists on classic central-European dishes like wiener schnitzel. No visit to Berlin is complete without sampling the iconic currywurst – a sizzling bratwurst doused in addictive curry ketchup, served with a mound of crispy fries or a crusty bread roll.
What are the top things to do in Berlin?Berlin's home to some of the world's best nightlife, so be sure to explore its countless bars and clubs. Hotspots are scattered all over town, but the hip districts of Neukölln, Kreuzberg and Friedrichshain have the highest concentration of venues. If you're feeling a little worse for wear in the morning, head to a shimmering lake on the outskirts of the city. Wannsee is the best loved, with its expansive swimming lido and sandy beach. Culture vultures, meanwhile, should peruse the priceless artworks and historical artifacts you'll find on Museum Island.
What are some fun facts about Berlin?Berlin might conjure up images of urban sprawl, but the city boasts over 100 miles of navigable waterways and more bridges than Venice. Europe's first electric traffic lights were installed in 1924 on Potsdamer Platz, which at the time was the continent's busiest intersection. And Berlin is the only city on the planet to boast 3 world-class opera houses – the Deutsche Oper Berlin, the Berliner Staatsoper, and the Komische Oper.
What kinds of public transport are there in Berlin?Travel in Berlin is efficient and affordable, thanks to an extensive public transport network, which encompasses overground and underground trains, trams, and buses. Tickets are available in vending machines at train stations, and are valid on all modes of transport. English instructions are available, but be aware only local bank cards are accepted, so have some cash handy. Regular train services run until around 1am on weekdays, and throughout the night on weekends – great news for those exploring the city's club scene. Many bus routes also operate a 24-hour service.
Berlin Travel Guides & Things To Do
Where to eat in Berlin – a food and dining guide
A fusion of Western and Eastern German cultures over the last century culminating with the fall of t...
What to see and do in Berlin – a guide to notable attractions and landmarks
Since the fall of the Berlin Wall in 1989, tourism has exploded on this hipster scene providing deli...
A Berlin travel guide – historic journeys, speciality shopping and fizzing nightlife
From grand boulevards bankrolled by Prussian royals to exuberant parties in canalside bars - a Berli...


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Foreign brands enter China through e-commerce
Alibaba's Tmall Global now features goods from 14,500 overseas brands, 80% of them selling in China for the first time.
Foreign brands enter China through e-commerce
Alibaba's Tmall Global now features goods from 14,500 overseas brands, 80% of them selling in China for the first time.
Less than a month into the New Year and the e-retailer and marketplace announces plans for three additional U.S. fulfillment centers.
Sign up for IRNewsLink and get daily reports delivery to your inbox. Sign Up Now
Sponsored by 2013 Social Media 300
The children's book publisher will debut a mobile gaming app and a Facebook page.
Scholastic Inc. is rolling out a mobile and social media initiative this spring in an effort to connect teens with their favorite authors and books, the publisher and children's book retailer announced today.
The program dubbed "this is teen" will kick off on April 26, 2011, and will include a Facebook page where readers can communicate with authors and each other. The page will feature author videos, blog entries, contests, trivia and giveaways.
"Our goal with 'this is teen' is to create a destination and a community for readers—a virtual book club experience where the conversation starts with books," says Stacy Lellos, vice president of marketing for Scholastic, No. 49 in Internet Retailer's Top 500 Guide.
The retailer is also launching a location-based mobile gaming app where users can accumulate points, and be instantly enrolled in a sweepstakes for prizes. The app includes book-related challenges like coming up with the best opening line for a story, snapping photos of specific titles at participating bookstores, and getting books signed at author events.
Scvngr, a provider of location-based mobile app technology, will provide the mobile gaming platform. "When targeting a teen audience, it's absolutely crucial to include a mobile component in your brand's campaign to drive engagement and recall," says Chris Mahl, senior vice president at Scvngr. "Not only will Scvngr's social game engine create deeper engagement for the audience already in bookstores, it will also provide a platform for friends to share their in-store experiences, effectively driving more traffic to bookstore locations."
Scholastic is Scvngr's first publisher client. The location-based gaming provider also works with multichannel shoe retailer Journeys, a unit of Genesco Inc.
Use that stellar email list you built during the holidays to market new products or ...
Posted 01/18/17
Amazon, for example, posts holiday ads to amazon.blackfriday.
Posted 01/17/17
The Supreme Court is surely going to find this question right back on their doorstep next year."

subset: commoncrawl


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Article Side
Online Article Directory!
Business Card Printing and the Digital Age
We are in the digital age. Everywhere you look and whatever you do, you would notice the influence of the digital age. In business, the influence of this age is felt clearly. Businesses today use online marketing when they want to promote to customers and prospects. This makes marketing so much easier for them allowing them to communicate to their customers without so much of a hassle.
But despite the modern advancement in marketing and in technology, it is still important that you take advantage of traditional marketing to ensure that you are able to communicate to all types of customers. When you attend trade fairs and conferences, people would still ask for your business cards. As such, it is vital that you still create your own business card printing so you can easily hand out your contact details to everyone who will be interested in your offerings.
But before go ahead with your business cards, here are simple pointers to help you get the job done right:
1 – Consider your business cards as a representative of your business. It's vital that you think of your cards as your representation. As much as possible, don't create a generic design for your cards. You need to come up with a unique design that will embody your business and serve as your best representation. If you want to put your photo in your cards that would be better as this will promote name recognition.
2 – Price is not always the determinant of good quality. Just because your business card cost you a fortune doesn't guarantee you high quality service. It's important that you make sure your design is impressive and catchy if you want people to keep your card and use it. Some of the successful cards these days don't really cost a lot. Even with a minimal investment, you can easily and effectively create your cards.
3 – Creativity sells. Make sure to come up with a creative design so you can make your cards impressive. With a little imagination, you can easily come up with the perfect cards for your business. Although there are business card templates you can use, this won't let you be creative and showcase your business in the most appealing manner. You can use whatever image you want as long as it will best represent your business.
4 – Use colors. A colorful card will always look visually appealing. Invest in full or four color printing so your cards will look amazing. There are plenty of colors to choose from today. Use the best colors that best reflect the image that you want to project through your cards.
5 – Tweak your design. You can showcase your artistry in your cards. Create a unique shape or size that will make your card look enticing and one of a kind. The more distinct you design is the easier it is to capture people's attention.
6 - Update your cards when necessary. If there are changes in your contact details, you need to immediately create new cards. Don't just crash out the outdated info and write on top of it the new info. This won't help you get a professional image.
Modern printing techniques will allow you to print high quality business cards. Invest in effective but affordable printing techniques and you can be sure to get the best business cards you can ever have.
Michelle M. Abreu - About Author:
Michelle Abreu has been writing articles online for about 2 years now in a trusted printing company. You can visit this website for more information about online cheap business card printing, and watch out for more free and eye catching business card templates custom made for your taste.
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Mexican Independence Weekend Celebration
There's no better way to celebrate Mexico's freedom than with a weekend of spicy south-of-the-border food and drink specials. On Friday, T&T will kick off the party with $5 fiesta nachos, habanero wings, chicken quesadilla, flautas and guacamole. Patrons can also partake in $5 Jose Cuervo shots and Dos Equis Lager, in addition to $5 well drinks, house red and white wine and sangria while T&T's sexy resident DJ, Mika Gold, will keep the party going with an energetic set on the turntables. Guests can finish off their weekend with Mariachi brunch on Saturday and Sunday from 11 a.m. to 3 p.m. The menu offers generous brunch selections to appease any appetite, including chilaquiles, T&T's signature breakfast burrito and huevos rancheros. Guests may complement their Mexican feast with a two-for-one Bloody Marias and two-for-one top shelf margaritas.
In addition to the delicious brunch menu and mouth-watering cocktail selection, T&T's house Mariachi band, "The Kings of Cuervo" will serenade guests in true mariachi style with everything from "Save the Last Dance for Me" by The Drifters to "I Got a Feeling" by The Black Eyed Peas.
When: Sunday, Sept. 18, 2011
Where: Tacos and Tequila , 3900 S. Las Vegas Boulevard, Las Vegas
Cost: Not available
Age limit: Not available
Categories: Las Vegas, The Strip, Holiday Event
Event posted Aug. 11, 2011
Last updated Aug. 11, 2011
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- The Park, 3784 Las Vegas Blvd. S., Las Vegas, NV 89109


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5 room apt in Old TownSuèdeStockholms länStockholm
À propos de ce logement
The apartment will be open for bookings again January 2016. Please feel welcome to make a request then. Kind regards, Elena and Jon
The apartment will be open for bookings again January 2016. Please feel welcome to make a request then. Kind regards, Elena and Jon
Within walking distance to most of the attractions of Stockholm. In addition 2 subway stations and all the major bus services within a 2-3 minute walk. Boat to lovely Djurgården just a stone's throw away and the whole of amazing Old Town just outside
We interact as much as our Guests want. We will not be present during our Guests' stay, but we will always be available on phone or mail for questions.
Our phone numbers: Jon +(PHONE NUMBER HIDDEN), Elena +(PHONE NUMBER HIDDEN). Our mail: (EMAIL HIDDEN) and (EMAIL HIDDEN)
Since the apartment is situated in the middle of so many restaurants and outdoor seating, it can be a bit noisy at times. But if one prefer almost complete silence, it is only to close the windows:)
Needless tho say, the apartment is very precious for us. We therefore hope and presume that our Guests will treat it in the same manner as if it was their own. When it comes to cleaning, we furthermore expect the apartment to be left in the same condition as it was at arrival:)
Votre hôte
Elena & Jon
We are a couple living in Old Town in Stockholm in the winter and in Katthammarsvik in Gotland in the summer. We work as Swedish teachers for immigrants half time. The other half time we work with projects of our own, such as a shoe-patent, water-color paintings, opera and social innovations. And - lucky us - there are also Thea (17), Samuel (13) and Stella (10) - and Dante (our dog) and Hippie (our rabbit). Elena is half Spanish and Jon has lived extensively in East Africa (so almost half African:) We all love to travel, and to meet new people from all around the world - especially harboring them as our cherished guests. So please feel welcome to our apartment in Stockholm and/or house in Gotland!


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A leading Auckland restaurant, Wine Chambers Restaurant offers a Mediterranean influenced menu from a bustling central Auckland building.
Fine Dining in Auckland Central
Auckland Fine Dining Restaurants like to compete for the regular food awards given out here. So whether you're 20 storeys up, or 20 feet from the beach, standards are high. You'll find gourmet excellence in this city.
In the CBD, Wyndham Street and Symonds Street both have some very good restaurants. Devonport, Epsom and Ellerslie also have their fair share. In Parnell and Ponsonby, there are some real gems hidden amongst the boutique hotels and trendy streets. Listening to what the locals say about 'the' place to dine, can be worth it's weight in gold-leaf desserts.
Filter 'Restaurants'
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- American (4)
- Asian (43)
- Bar and Bistro (47)
- Cafe (43)
- Casual Dining (52)
- Chinese (8)
- European (24)
- Fine Dining (29)
- French (11)
- Halal Cuisine (4)
- Indian (17)
- International (10)
- Italian (24)
- Japanese (20)
- Mediterranean (21)
- Mexican (4)
- New Zealand (44)
- Pizza (23)
- Seafood (23)
- Spanish (6)
- Steak (18)
- Takeaways (16)
- Thai (15)
- Vegetarian (4)
Filter 'Fine Dining' by Region
Coco Restaurant & Wine Bar is a fine-dining establishment located to the south of Cornwall Park in the quiet suburbs of Royal Oak, Auckland.
It's perhaps not surprising that Vinnies has become one of Auckland's premier fine-dining establishments.
Fish as the name suggests, delivers creative fish dishes served to a backdrop of eye catching harbour views.
Located in the bustling Jervois Road, in the Auckland suburb of Herne Bay, Andiamo has been entertaining diners for nearly 30 years and has won several awards during its lifetime.
Located in Quay Street in central Auckland, Harbourside Ocean bar and grill boasts an outside dining deck with retractable roof allowing diners to eat alfresco whatever the weather.
Intimate bistro in the city centre, with public and private dining spaces, award-winning wine selection, eclectic European menu and contemporary interior.
Nestled in the stylish interior of Hotel DeBrett, the Kitchen Restaurant delivers a fresh and original dining experience in Auckland's CBD.
Located in the lobby area of Auckland's downtown Stamford Plaza Hotel, Knights On Albert Restaurant offers diners a contemporary décor, serving modern New Zealand cuisine.
Italian-themed restaurant located in The Langham Hotel. Classy fine-dining with dishes cooked by authentic Piedmont chefs. Extensive, premier wine list mixing Italian reds with NZ whites.


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At some point, every country builds a Great Wall to keep the secret of its cuisine from spreading to foreign nations, only to find that the real wall lies in its heart. Tear down the Great Wall of painful secrets with today's Groupon: for $13, you get dinner for two at Four Seasons Chinese Restaurant (up to a $26.40 value). The dinner includes:
- Two entrees (up to a $23.90 value)
- Two eggrolls (a $2.50 value)
Chefs steer the stoves at Four Seasons Chinese Restaurant across a sea of classic Chinese dishes made with fresh meats and vegetables mapped out on their lengthy menu. Diners toast their pair of eggrolls before moving on to stir-fried entrees cooked exclusively in vegetable oil as opposed to greasy fats or butter sandwiches. The Four Seasons delight simmers a meaty mélange of beef, chicken, shrimp, crabmeat, and scallops with mixed vegetables before glazing the entire platter in a signature Four Seasons sauce. Platefuls of shredded pork douse themselves in a garlic sauce spicy enough to make chili peppers turn burgundy, and the spicy orange chicken bastes taste buds in gustatory firecrackers. Chefs eschew the incisor-tempting flavors of meat altogether and present diners with a selection of vegetable entrees that includes the savory aromas of Chinese mushrooms cooked alongside panda-approved bamboo shoots.
Wells Branch
14735 Bratton Ln.
Suite 255
Austin, Texas 78728Get Directions


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You actually don't even need to upgrade your current DC (though the upgrade to R2 itself is usually rather harmless), it's enough to update the AD Schema to be able to join the new DC.
Licensing will be fine (if it was until now), R2 uses the same CALs as W2k3.
Steps for Extending the Schema
Error message when you run the Active Directory Installation Wizard: "The version of the Active Directory schema of the source forest is not compatible with the version of Active Directory on this computer"


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Murder Most Foul Comes to Forest Park
One of the stereotypes of the Midwest is that we are decent. It comes up all the time in discussions about regional differences. You know the types—east coast people are pushy and impatient. West coast people are so laid back they're nearly dead. The south is overrun with bigots and the Midwest is full of just plain folks.
For hard-working, decent folk we seem to have a lot of murderers in our midst. John Wayne Gacy, H.H. Holmes, Richard Speck, Leopold and Loeb for starters. In his recently released book, Heartland Serial Killers, Richard Lindberg brings to life two pragmatic criminals who married and murdered repeatedly for money—Johann Hoch and Belle Gunness.
Neither party was particularly glamorous, at least by today's standards, but they both managed to swindle, strangle (among the diverse ways they dispatched inconvenient spouses) and have sexual liaisons with many, many people. The aim for both was money and sexual gratification. Aided by the primitive forensics of the time, poor communication between law enforcement agencies and the intense desire of their victims for marriage, these two practiced serial monogamy on a grand scale. However, instead of disposing of their unwanted partners in divorce, which can be so messy and costly, they resorted to murder.
The author discusses the social milieu of the time as one where people married for economic stability. Immigrants had left behind in the old country the social fabric of large, interconnected families that provided a cushion against the ravages of time. Instead, they hoped that marriage, particularly with another person of modest means would be a hedge against penury and loneliness in old age. And of course, they hoped they would like one another and find some physical comfort.
Hoch and Gunness practiced their scams for several years and within a few miles of each other, although there is no evidence that they knew one another, before serious suspicions were aroused despite the seemingly hap-hazard way they chose their victims through marriage bureaus and lonely hearts ads. Even today, first generation immigrants tend to be insular and prefer to marry within their own groups. This phenomenon was even more pronounced in the 1880s. Hoch preyed on middle-aged German women and Gunness specialized in Scandinavian men.
The ability of Johann Hoch to escape detection for as long as he did was more understandable than how Gunness managed to avoid discovery. He traveled incessantly and stayed ahead of suspicious police and others in authority by taking off to Pennsylvania, Germany and back to Indiana on a whirlwind schedule. This guy was a fast talker too—within hours of meeting a suitable woman he would propose marriage. A surprising number of supposedly sane and normal women took him up on it. All of his victims are not known, but it is estimated that he murdered twelve women and at least nineteen more were swindled out of their life savings and left abandoned and destitute. In the end, he was caught and hanged but he never admitted his guilt.
He must have had tons of charisma, though. One of his swindled "wives" (it was not a legal contract since he was still married to someone else) testified against him and then threatened suicide when he was sentenced to death. This was after she was well aware of his part in the poisoning death of her sister.
Belle Gunness, on the other hand, was never caught but did most of her known nefarious crimes in La Porte, Indiana and brought her victims to her house where she stabbed them, cut them up and buried them in her pasture. She wasn't well liked by her neighbors and there were strange rumors that circulated about her, but she was still not seen as a murderess until the day she allegedly drugged her children and her current boarder, put the headless body of a homeless woman in her house and set the whole thing on fire that real questions began to be asked. Then the authorities unearthed many bodies, one of them a corpse preserved enough to be identified by the man's brother, on the farm she owned.
Belle would send letters to men promising a quiet life (well, death IS quiet) with a loving woman who owned a farm. She was only interested in men who had assets and would pepper them with requests for help with her mortgage. Once they got to her house, they stayed awhile and then they all left on "trips", conveniently leaving all their earthly possessions behind. Gunness may have had as many as thirty-nine victims, mostly men. She also dispatched at least four children and two women.
The author appeared at Centuries & Sleuths a few weeks ago. He agreed to talk to me later at Panera's where I asked him who he'd written the book for. It is well-researched but the prose is more academic than sensational. Lindberg presents the crimes as reprehensible and the victims as forgotten but still deserving of the reader's serious attention. He is perplexed by the tendency to trivialize the suffering of the victims, particularly in the case of Gunness's crimes.
Lindberg said that he hadn't really thought about the audience when he wrote it. He's fascinated with true crime and history. A Chicago native, he has written about the White Sox, crime and politics in the city. His book, The Gambler King of Clark Street has won multiple awards. He also gives tours through the Chicago History Museum and is the past president of the Midland Authors Society. Lindberg confesses that he loves the Gas Light Era of the City and can imagine himself living at that time. It shows in the book which has rich detail about the city in the late 19th century.
This is a book for the serious reader of true crime. It provides detail about the era and the criminals, but is not a page-turner which will keep you up late. However, it will make you consider that maybe the good old days weren't so good after all.
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Colour | Cosmetics Business News | North America
Avon has appointed James Scully as Executive Vice President and Chief Financial Officer. Scully previously worked at multi-channel retailer J. Crew, before taking up his new role. Scully will now lead all finance and IT functions. Scully will report into CEO Sheri McCoy, effective no later than 1 April.
I am very pleased to welcome Jim to the Avon team, said McCoy. His deep consumer expertise, track record of working in complex environments, and experience developing opportunities in international markets make him the ideal fit for Avon. He is a seasoned finance and operational leader with public company CFO experience and will play an integral role in driving sustainable and profitable growth at Avon.
Scully added: Avon is an iconic beauty brand and I'm excited to join the team. This is a pivotal moment for Avon as it seeks to reinforce its leadership in beauty and direct sales. I look forward to working with Sheri and the entire management team to help get the business back on a path to sustainable growth while continuing to fulfill the company's mission of empowering women.
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Latest Weather Blog
Ascension roads to get critical fix
PRAIREVILLE- A list of dozens of roads in Ascension Parish in need of critical repair was approved by the parish council. At least 39 roads are considered in critical need of repair and will get a fix within the next few months.
The parish will seek bids for the work and start immediately once a bid is accepted.
One neighborhood is in for an entire rehab, Wallace Acres, near La 44. Every street in that subdivision is due for repair.
"The roads are terrible in this subdivision, they breakup every time we get a hard rain," said Euna Blakeman, who lives on one of the worst roads. "They come through and fill the holes up with tar, you never know whats gonna happen in this subdivision with the roads."
The parish will start with the roads in critical need of repair and then move down their priority list until the money runs out.
You can see the master list by clicking here.
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Prairieville man arrested for impersonating a police officer
State officials respond to The Investigative Unit's report on Hwy 190 in...
Cemetery still working to identify bodies disturbed by August flood
Walker subdivision still having drainage problems
Senator Cassidy unveils plan to replace Affordable Care Act


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Top Definition
All the under-the-sink chemicals you can find put together.
Bill; Hey what'd you do last night?
Hunter; Me and Jack made some Chrimick and got fucked up!
Hunter; Me and Jack made some Chrimick and got fucked up!
by Chupabooboo May 07, 2011
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Morning Poll -- A.J. Hinch Getting the Boot as Diamondbacks' Manager: Too Soon or Not Soon Enough
The way the Arizona Diamondbacks have played this season, it seemed only a matter of time before heads began to roll.
Last night, those heads got rollin' -- news leaked that the team will give the axe to manager A.J. Hinch and general manager Scott Byrnes at a press conference at 10 a.m. today.
During Hinch's tenure with the team, the D-Backs had an embarrassing record of 89-123, which is good for a winning percentage that's a solid 80 clicks below .500.
Winning percentage aside, a lot of the games lost this season can be directly attributed to the team's horrendous bullpen and a collection of torturous eighth and ninth innings where pitching has often let games slip away.
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Hinch, who had no managerial experience prior to his gig with the D-Backs, will be replaced by the fist-pump kid himself, Kirk Gibson.
We want to know what you think: Should Hinch been given the boot sooner or should he have been allowed more time to turn the team (by team we mean bullpen) around?
Vote -- and see the results of yesterday's poll -- after the jump.
Yesterday's poll question: Is John McCain's Latest Web Ad "Unbecoming of a Senator?"
-31 percent say yes.
-31 percent say no.
-38 percent say yes, but not as "unbecoming" as starring in an infomercial.
Here is your morning poll:
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at Weebly San Francisco, CA Weebly is looking for a Senior Android Engineer to join our team to work in our application with a rating of 4.2 stars, over a million installs and the fastest growing product in the company. As well as being Google Play preferred developers. You11/13/2016 San Francisco, CA Save This Job
ALAMEDA, CAPRODUCTIONFULL-TIME APPLY FOR THIS JOB As a Training Supervisor on our production team, you will play a key role in ensuring that Penumbra continues to provide employees at all levels with the skills they need to grow with the company. You will help guide the training11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAPRODUCTIONFULL-TIME APPLY FOR THIS JOB As a key member of our production team, your will ensure that the equipment we use to manufacture and test medical devices is continually in optimal condition. Working with a team of engineers and technicians, you will share in11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAITFULL-TIME APPLY FOR THIS JOB In a pivotal new position with Penumbra's growing IT team, you will take the lead on website development, enhancement and web-based applications, ensuring strong optimization and functionality. You will work across many departments and11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAITFULL-TIME APPLY FOR THIS JOB As a key member of the Business Process Management team at Penumbra, you will be identified as the application expert responsible for streamlining our business processes to support the Company's growth. Participating on project teams to11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAITFULL-TIME APPLY FOR THIS JOB As Penumbra's first analytics, integration and development lead, you will have the opportunity to define the roadmap and architecture to support Penumbra's future growth. You will work closely with various teams across the organization to11/13/2016 Alameda, CA Save This Job
COLORADOCLINICAL AFFAIRSFULL-TIME APPLY FOR THIS JOB As a member of our clinical research team, you will participate in the execution of clinical studies to assess the safety and effectiveness of Penumbra?s products. Based in the Colorado area, you will work with confidential11/13/2016 Alameda, CA Save This Job
Category:Product Management Locations:Emeryville, CA Position Type:Regular Full-time Description MobiTV is looking for a Product Manager with a unique blend of business and technical savvy; a big-picture vision, and the drive to make that vision a reality. You must be able to11/13/2016 Emeryville, CA Save This Job
Responsibilities: Be the voice of the customer. Understand our customers better than anyone and be a champion for their needs Go-to-market strategy and execution for the Rescale platform and market segments Messaging, positioning and core content that communicates the value of11/13/2016 San Francisco, CA Save This Job
Overview Matisse Software, developer of the Post-Relational SQL database, is seeking for a Senior Software Consultant. In this position you will be responsible for the successful deployment of Matisse-based applications on Unix Systems. This position involves frequent travel11/13/2016 Mountain View, CA Save This Job
ALAMEDA, CACLINICAL AFFAIRSFULL-TIME APPLY FOR THIS JOB Ground-breaking clinical trials require seamless software solutions. In this role, you will work with minimal supervision to support a portfolio of post market and regulatory clinical trial electronic systems. You will take11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAFINANCEFULL-TIME APPLY FOR THIS JOB As a leader in Penumbra's growing Finance group, the Accounting Manager will participate in the monthly close process, perform financial statement analysis and assist the Controller with technical accounting issues. THE11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAENGINEERINGFULL-TIME APPLY FOR THIS JOB In a pivotal role on our manufacturing team, you will provide leadership and drive results in the engineering, design and development of Penumbra's life-saving products. Working cross-functionally with Production, R&D, Quality,11/13/2016 Alameda, CA Save This Job
ALAMEDA, CAENGINEERINGFULL-TIME APPLY FOR THIS JOB As Penumbra's first Data Integration Specialist, you will take the lead on coordinating the movement, manipulation, integration, quality and availability of data throughout the enterprise, bringing your Extract, Transform and11/13/2016 Alameda, CA Save This Job
SAN FRANCISCOMARKETINGFULL-TIME APPLY FOR THIS JOB Do you love developing strategies and executing programs that segment, activate, grow and retain customers? We?re looking for a very analytical Manager of Retention Marketing to lead the strategic development, testing and11/11/2016 San Francisco, CA Save This Job
SAN FRANCISCOMARKETINGFULL-TIME APPLY FOR THIS JOB We are looking for a self-motivated, data-driven analytics expert to join the eCommerce and marketing team at ThirdLove. Thoughtfully sift through our mounds fascinating customer data to extract meaningful insights and recommend11/11/2016 San Francisco, CA Save This Job
SAN FRANCISCOENGINEERING AND OPERATIONSFULL-TIME APPLY FOR THIS JOB As a Front End Developer focused on growth, you will be responsible for helping to scale a fast growing multi-channel brand and technology platform across web and mobile web. Your mission is to create purposeful,11/11/2016 San Francisco, CA Save This Job
San Francisco, California, United States Services DESCRIPTION Cedexis is hiring for a Technical Service Engineer who will work in our New York City and San Francisco Offices. The Technical Services Engineer (TSE) is a customer-focused technical services professional who11/8/2016 San Francisco, CA Save This Job
Development - Mountain View, CA - Full Time WHY BE INTERESTED? You are excited about building enterprise-scale cloud-based platforms that act on huge data sets. You enjoy building new applications for the world?s leading companies. You like start-ups, but also enjoy the11/7/2016 Mountain View, CA Save This Job


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Vila Ozon
Stefan Cel Mare nr.35, 905350 Eforie Nord, Romania – Great location - show map
Excellent location — rated 10/10! (score from 1 reviews)
Rated by guests after their stay at Vila Ozon.
|Room type
|Triple Room
|King Room
Vila Ozon, built in 2014, it is a modern and clean touristic property, with new furniture.
Vila Ozon takes special requests - add in the next step!
5 reasons to choose Vila Ozon
Low rates
Manage your bookings online
112,050,000 independent reviews
The staff speak English
Booking is safe
Facilities of Vila Ozon Great facilities! Review score, 10
- Terrace
- Shared kitchen
Pets are not allowed.
- Water park
- Beachfront
- Diving
Free! WiFi is available in all areas and is free of charge.
No parking available.
- Air conditioning
- Heating
- Non-smoking rooms
Languages spoken
- Romanian
- English
- German
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Property surroundings – Great location - show map
Closest landmarks
- Constanta Train Station 6.6 miles
- Tomis Marina 6.8 miles
- Constanta Casino 6.9 miles
- Acquarium 6.9 miles
- The Roman Mosaics 7 miles
Most popular landmarks
- Ovidiu Square 7.1 miles
- Tomis Yachting Club and Marina 7.2 miles
- Costinesti Shipwreck 7.8 miles
- The Costinesti Obelisk 8.7 miles
- City Park Mall 9 miles
From 14:00 hours
Until 11:00 hours
Cancellation and prepayment policies vary according to room type. Please enter the dates of your stay and check the conditions of your required room.
Children and extra beds
Children cannot be accommodated at the hotel.
All further children or adults are charged EUR 12 per night for extra beds.
The maximum number of extra beds in a room is 1.
Any type of extra bed or child's cot/crib is upon request and needs to be confirmed by management.
Supplements are not calculated automatically in the total costs and will have to be paid for separately during your stay.
Pets are not allowed.
Cash only
This property only accepts cash payments.
No review score yet ...
We need at least 5 reviews before we can calculate a review score. If you book and review your stay, you can help Vila Ozon meet this goal.


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Palatka, Florida, United States Trip Planner
Palatka Itinerary Planner
Find the best activities, restaurants and things to do in Palatka, United States. Explore Palatka travel guide before you plan your trip here. The nearest major city to Palatka is Orlando. Take a short trip from Palatka and set some time aside to explore the Orlando. Dotted with places like Flagler College, St Augustine Lighthouse And Museum, St Augustine Alligator Farm; it will definitely be a good idea. Also, to reach Palatka, you'll have to take a flight to Orlando; so its not really a detour. And even if it is, the city is worth paying at least a quick visit. Get in the character of the city, this city requires at least of 1 to 2 number of days of exploration.
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text:
Ooh, the Aardvark can see lots of his "Bird and Branch" items living in here!
modern rustic <3
Antique bird cages
paint the back of a bookshelf an awesome bright color
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Filter Results Showing 36001 - 36030 of 49310 results
TerraLink Horticulture Inc. Manufacturer Retail
Abbotsford, British Columbia
Terralink Horticulture is a leading supplier of fertilizer, pesticide, seed products & equipment for agriculture industries. We manufacture & distribute throughout Canada supplying nutrient & disease control inputs for every growing situation.
Equal Door Industries - Div. of Ambassador Sales (Southern) Ltd. Manufacturer
Calgary, Alberta
Provide quality overhead doors of all types. Offering a complete line of products for commercial and residential applications
Dumur Industries Ltd. Manufacturer
White City, Saskatchewan
Welded fabrications, precision machining. Commercial food outlet air handling systems & stainless steel cabinetry
Hexeco Inc. Manufacturer
Berlin, Wisconsin
Design And Manufacture Bearing Oil Coolers For Large Generators And Motors. Replacement, Upgraded And New Designs. Finned Or Bare Tube/Pipe Construction.
Westcon Precast Inc. Manufacturer
Calgary, Alberta
Providing Service & Quality Precast Concrete Products To Alberta Contrators Engineers, & Architects For Over Thirty Years
Bevco Sales International Inc. Manufacturer
Surrey, British Columbia
Conveying systems for the bottling, canning industries, conveying systems & packaging equipment for the food & beverage industries
Blue Link Associates Services
Concord, Ontario
Complete Business Solutions, Encompassing Both "Back Office" Functions (Like Accounting & Collections), & Logistical / Operational Functions
Quirion Metal Inc. Manufacturer
Beauceville, Québec
Steel Fabricators, Metal Work, Architectural Metal Products


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Executive Formulation Development jobs
There are 610 Executive Formulation Development-related jobs on Neuvoo India. Apply now and get the job of your dreams.
Job descriptions and categories including this search
Examples of corresponding job vacancies are Lease Analyst, Purchasing Manager, Pharmacy Technician, Stage Manager, Public Relations Associate or Finance Manager. These job vacancies are often related to industries like IT, Management, Services, Sales, Customer Service or Engineering.
Employment statistics
Regions with the largest number of vacancies related to 'Executive Formulation Development' are Maharashtra, Karnataka, Gujarat, Tamil Nadu, Telangana or Uttar Pradesh. Cities with the highest number of hits are Mumbai, Bangalore, Chennai, Hyderabad, Gurgaon or Ahmedabad.
Top employers offering Executive Formulation Development jobs
Firms posting the most Executive Formulation Development-related jobs are Client OF Careerbridge Consultants, McGraw Hill Financial, B.N. Placement Services, SA Infrastructure Pvt Ltd, KENNY WHITE or Logic Spice.
Neuvoo India: the the largest job aggregator across India
Neuvoo India is the largest job search website in the country with over 1653679 vacancies available, 610 of which are Executive Formulation Development-related.Show more...
Sai Advantium Pharma |
Bidar, Karnataka
- 2d ago
Quality Assurance Quality Control Executive Role. Quality Assurance Quality Control Executive Desired... toxicology and formulation development. Our workforce of highly talented and experienced scientists is...
Zydus Cadila |
Ahmedabad, Gujarat
- 13d ago
Sr. Executive to Deputy Manager. Formulation Development. Should also have experience of dossier compilation and submission for emerging markets, with exposure to ACTD format. Qualification. M...
GenNext Human Resource Management |
(Unspecified city), Madhya Pradesh
- 5d ago
Should have good practical knowledge and experience of Formulation development in line with current regulatory requirements. Should have good exposure and skill to operate all Equipments and...
GenNext Human Resource Management |
Bhopal, Madhya Pradesh
- 5d ago
Should have good practical knowledge and experience of Formulation development in line with current regulatory requirements. Should have good exposure and skill to operate all Equipments and...
Innovative Placement |
Vadodara, Gujarat
- 7d ago
For Innovative Placement we are looking to quickly hire a Executive – Analytical Development (API / Formulation) in Vadodara. As a Executive – Analytical Development (API / Formulation) you duties will be also to ....
Insight Consultancy Services Pvt Ltd |
Mumbai, Maharashtra
- 3d ago
Job Description. Formulation development for regulated. Semi regulated markets. Experience in solid... Medical , Healthcare , R&D , Pharmaceuticals , Biotechnology. Role Category R&D. Role Formulation...
Profile HR Consultants Pvt Ltd. |
Mumbai, Maharashtra
- 2d ago
Job Description. Formulation and development of personal care products like creams, powders, oils, face... Functional Area. Engineering Design , R&D. Role Category R&D. Role R&D Executive. Desired Candidate...
Randstad India Limited |
Chennai, Tamil Nadu
- 11d ago
Job Description. Hands on experience in R&D. formulation development manager in Chennai. Salary... Staffing. Functional Area. Engineering Design , R&D. Role Category R&D. Role R&D Executive. Keyskills...
AMY Pvt Ltd |
(Unspecified city), Maharashtra
- 5d ago
Designation. Sr.Executive Research Associate Assistant Executive Manager Formulation & DevelopmentJob Location. Kandivali Qualification. M.Pharma Expierence. 5 12 Yrs Salary. As per industry std...
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Always On AMOLED - BETA
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মিনিটের আমল বা 1 Minute Amol অ্যাপটি আশা করি কিছুটা হলেও তা তুলে ধরবে। এক মিনিট সময়ের মাঝে অনেক ভাল কাজ
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Almighty Allah own no provision. Let us assume that the provision of services to improve the way the Islamic system. Muslims believe that the person's income and earnings, life and death, and good luck and bad luck, etc., in the belly of his mother when he was rnidharana. And for this he was awarded the sphere of allocation. Therefore, it is ou…
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1-14 of 14
Ladies M&S Floaty Per Una Dress Size 8R Green Floral Summer FrockThis dress is in excellent condition. It has a pretty floral pattern all over. It is cut on the bias and very flattering on.£4.500 bids£3.00 postageEnding Thursday at 7:28PM GMT1d 19h
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Fmc Palouse
Fmc Palouse was recognized and certified in 2009 by Centers for Medicare & Medicaid Services (CMS) as one of modern dialysis facilities which are scientifically measured and assessed to have high-quality dialysis services for promoting health and improving the quality of life. Fmc Palouse is located at 723 Main St Moscow, ID 83843 and can be contacted via phone number (208) 882-1817.
- Monday - Friday: 8:00 AM - 5:00 PM
- Saturday - Sunday: Closed
Quality Measures
Center for Medicare & Medicaid Services (CMS) regularly surveys the quality of dialysis services basing on different metrics which more or less reflects the overall conditions of patients after receving the services. This quality measures report is provided in order to help patients understand the dialysis services being offerred by Fmc Palouse and to help the facilities improve their service quality for promoting health. The following quality measures are collected, compiled and publicized on Oct 20th, 2016 by CMS
This dialysis data was updated by using the dataset publicized on Oct 20th, 2016 by the Centers for Medicare and Medicaid Services (CMS). If you found out anything that is incorrect and want to change it, please follow this Update Data guide.
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CASIO CSF5350 Owner's Manual
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Steven R. Hamilton, M.D. Neuro-ophthalmic Consultants Northwest Seattle Neuroscience Institute Seattle, WA
Neuro-ophthalmic Consultants Northwest
Overview of Myasthenia Gravis (MG)
• Definition
– A neuromuscular disorder manifested by weakness and fatigability of voluntary muscles
• Prevalence
– 50-125 cases per million population – 25,000 affected persons in the United States
• History of MG
– First described in 1672 by Thomas Willis
Neuro-ophthalmic Consultants Northwest
Physiology of MG
• Acetylcholine (Ach) packaged in vesicles on presynaptic neuron • Ach receptors (AchR) opposite the neuron in the muscle endplate • Action potential end plate potential • Ach degraded by acetylcholinesterase
Neuro-ophthalmic Consultants Northwest
Structure of the Neuromuscular Junction
Neuro-ophthalmic Consultants Northwest
Neuro-ophthalmic Consultants Northwest .
Immunopathogenesis of MG • MG is the prototypical autoimmune disease • Animal model – Rabbits and the electric eel (Torpedo californica) • Action of AChR antibodies – Reversible blockade of receptors – Conformation changes of the receptors – Inflammation and destruction of receptors (primarily through complement cascade) – Atrophy of receptor membranes with loss of folds Neuro-ophthalmic Consultants Northwest .
Neuro-ophthalmic Consultants Northwest .
the response begins to be directed against other antigenic regions (epitopes) on the original target or on neighboring antigens on the target • Results in a widened autoimmune attack and increased damage of the target receptors • Concept has radically changed treatment regimen of rheumatoid arthritis patients – Early aggressive intervention with anti-TNF (tumour necrosis factor) drugs in RA has been proven to prevent permanent joint damage Neuro-ophthalmic Consultants Northwest .Epitope Spreading Concept • During an autoimmune attack.
Osserman Classification • Group I-ocular MG • Group Ia-ocular MG with physiologic evidence of dissemination • Group IIa-mild generalized MG (no respiratory) • Group IIb-mild generalized MG + respiratory • Group III-acute fulminant MG (thymomas) • Group IV-late severe MG from groups I or II after 2 years Neuro-ophthalmic Consultants Northwest .
Ocular Myasthenia Gravis • Variable ptosis and diplopia – Presenting symptoms in 50-70% of patients – Eventually present in 90% of MG patients • • • • Lid twitch and enhanced ptosis Weakness of orbicularis oculi muscles Pseudo-internuclear ophthalmoplegia Normal pupils Neuro-ophthalmic Consultants Northwest .
"My left eyelid droops" • 66-year-old man with thyroidectomy 40 years earlier • Residual proptosis without diplopia • Droopy left lid for one month. worse at night • Transient double vision recently Neuro-ophthalmic Consultants Northwest .
Neuro-ophthalmic Consultants Northwest .
Pseudo-INO of OMG Neuro-ophthalmic Consultants Northwest .
Ocular MG Demographics • 14% (2021/1. 505: 472 Neuro-ophthalmic Consultants Northwest .487 patients) with localized ocular MG followed a mean of 18 years • Male: female ratio = 57:43 • Age of onset: male (43 yrs). female (32 yrs) • Maximum level of severity reached within 3 yrs in 85% Grob et al. Annals NY Acad Sci 1987.
or trunk weakness plus ocular 86% (1.487 patients) with generalized MG Male to female ratio = 41: 59 Age of onset: male (41 yrs). Annals NY Acad Sci 1987. 505: 472 Neuro-ophthalmic Consultants Northwest . female (28 yrs) Onset time from ocular to generalized MG: – 58% < 6 months – 20% within first year – 7% during 2nd and 3rd years Grob et al.285/1. extremity.Generalized MG Demographics • • • • • Bulbar.
Diagnostic Test Sensitivities Test Ocular MG AChR Ab edrophonium Repetitive nerve stim. Single fiber EMG Ice Test Neuro-ophthalmic Consultants Northwest 50% 60-95% 10-17% 82-99% 89% Generalized MG 90% 70-95% 53-100% 82-99% .
Edrophonium Test Neuro-ophthalmic Consultants Northwest .
Caveats on Diagnostic Tests • AChR Antibody (Ab) tests – If negative binding AChR Ab level • <4% positive modulating Ab • <1% positive blocking Ab – 50% of AchR Ab-negative patients have Ab to MuSK (muscle specific kinase) (rare in OMG) • SF(single fiber) EMG – 100% sensitive in SR-LP muscle groups – 62% sensitive in OO group alone Neuro-ophthalmic Consultants Northwest .
Treatment of OMG • Two potential goals – Return the person to a state of clear vision – Prevent or limit the severity of generalized MG • Treatment options – Mechanical (patching) or strabismus surgery – Medical therapy • Symptomatic (pyridostigmine bromide) • Immunosuppression – Thymectomy Neuro-ophthalmic Consultants Northwest .
The Dangers of Patching ocular MG Patients • Too often patients are abandoned to poor quality of life without the chance of binocular vision • An easy fix for the treating neurologist without consideration of the long-term implications for quality of life and the risk of generalization of the disease Neuro-ophthalmic Consultants Northwest .
Pyridostigmine Therapy of ocular MG • Improves visual disability in 20-40% of OMG patients • Most effective for isolated variable ptosis • No immunomodulatory effect to prevent generalization of disease • May actually mask underlying progression of disease or even permit epitope spreading Neuro-ophthalmic Consultants Northwest .
" • Observational studies (cohort and case studies) suggest corticosteroids and azathioprine may reduce the risk of generalization of ocular MG Neuro-ophthalmic Consultants Northwest .Immunosuppressive Therapies for Ocular MG • Cochrane Review 2006 – "There are no data from randomized controlled trials on the impact of any form of treatment on the risk of progression from ocular to generalized myasthenia gravis.
60(2):243-8 – 147 pts with ocular MG – Treated with 6 weeks of 40-60 mg prednisone per day with gradual taper to once-a-day or alternate-day low-dose therapy (2.Corticosteroids for Ocular MG • Kupersmith et al. 2003 Feb. Arch Neurol. 36% development of generalized MG Neuro-ophthalmic Consultants Northwest .5-10 mg) – 2 years follow-up data – 7% vs.
Corticosteroid Therapy for ocular MG • Monsul et al. J Neurol Sci.217(2):131-3 – 56 ocular MG patients • Treated patients received 60 mg prednisone per day with slow taper over 3-6 months • 2 year follow-up • 11% vs. 2004 Feb 15. 35% development of generalized MG Neuro-ophthalmic Consultants Northwest .
1997 Feb. J Neurol Neurosurg Psychiatry.Combined Therapies for Ocular MG • Sommer et al.62(2):156-62 – 78 pts with ocular MG with mean duration of disease of 8 years – Only12% generalized if on corticosteroids (45). azathioprine (27). or both (23) – 64% generalized if on no immunosuppression • Thymectomy for abnormal chest CT also correlated with good outcome Neuro-ophthalmic Consultants Northwest .
Combined Therapies for OMG • Mee et al. J Neuro-ophthalmol. 2003 Dec.23(4):24950 – Retrospective review of 34 patients who are positive for AChR Antibodies – Treatment with corticosteroids and/or azathioprine – 2 years of follow-up – 21/34 (62%) patients generalized • 9% of those on immunomodulatory therapy generalized • 86% of those on pyridostigmine alone generalized Neuro-ophthalmic Consultants Northwest .
• Better tolerated than azathioprine and cyclosporine (less nephrotoxic) Neuro-ophthalmic Consultants Northwest . Rare bone marrow suppression.Mycophenolate mofetil • Pro-drug of mycophenolic acid – first isolated in 1898 from Penicillium • Inhibits lymphocyte purine synthesis by reversibly and noncompetitively blocking inosine monophosphate dehydrogenase. • Highly specific for lymphocytes • Side effects: gastrointestinal upset. increased liver function tests.
increasing gradually to 1-2 gms/day in twice a day schedule • Take on an empty stomach • Avoid pregnancy (class C drug) • Check complete blood count. liver function tests every 4 months Neuro-ophthalmic Consultants Northwest . then 250 mg twice a day for 1 week.Mycophenolate mofetil (MM) for MG • Faster onset of action than azathioprine – 2-4 months average • 250 mg/day for 1 week.
6% discontinued due to side effects Neuro-ophthalmic Consultants Northwest . (Neurology 2003) – – – – – Retrospective review of 85 patients 28 seronegative Dosages ranged from 1-3g/day 56% with prior thymectomy 73% achieved pharmacologic remission or significant improvement – Maximal benefit at 26 weeks.MM Trials for Generalized MG • Meriggioli et al.
placebo-controlled trial • 12 week duration • MM plus prednisone vs prednisone alone (20 mg dose) • No significant difference in outcomes • MM well tolerated Neuro-ophthalmic Consultants Northwest .MM Trials for GMG Aspreva sponsored trial (Donald Sanders @ Duke) • 80 patient double-blind.
5 Women • Average age at presentation: 52 (23-77) • Average Follow up on MM: 17 months (6-41) – Diagnostic Tests • 9/14 AchR Ab+.Treatment of ocular MG with MM Hamilton et al. 1 thymic hyperplasia Neuro-ophthalmic Consultants Northwest . 1 MuSK + • edrophonium test 4/7 tested +. • Retrospective review of 14 patients with ocular MG treated with Mycophenolate mofetil – Demographics • Gender: 9 Men. 7 not performed • CT chest – 9/10 negative.
Study Design • Patients were started on MM for one of three reasons – Primary agent besides pyridostigmine (3/14) – Worsening symptoms on other immunosuppressives (8/14) – Tapering off other immunosuppressives (3/14) Neuro-ophthalmic Consultants Northwest .
• Minimum duration of treatment for at least 6 months. • Blood monitoring of complete blood count with differential and liver function tests.Study Design • Starting dose MM 250mg daily with gradual increase to target dose of 1 gm twice a day. – Initially every 2 weeks – Quarterly when patient reached maintenance Neuro-ophthalmic Consultants Northwest .
1 patient reached 1.750 mg daily • 2 patients discontinued the medication – 1 due to development of cellulitis – 1 due to lack of response Neuro-ophthalmic Consultants Northwest .Results • 13/14 patients were able to reach a maintenance dose of 1g twice a day.
1 patient discontinued due to development of cellulitis • No patients converted to generalized MG Neuro-ophthalmic Consultants Northwest .Results • Based on MGFA assessment: – 8/14 in pharmacologic remission – 4/14 improved – 2/14 no change or worse • Mean time to objective improvement: – 2 months • Side effects: 4/14 had mild liver enzyme abnormalities.
later for weakness • Mulder et al series – 249/781 patients with moderate-severe MG had thymectomy – 87% benefited with supplemental medication – 51% achieved remission – Patients with thymoma responded least well – Onset to improvement may take months-years Mulder et al.146:61 Neuro-ophthalmic Consultants Northwest . Am J Surg 1983.Thymectomy • Introduced for thymoma.
Indications for Thymectomy • • • • Ocular only Thymoma All generalized Selected generalized – – – – • "few" • 100% • 5% – – – – 57% 38% 25% 21% Young onset Disabling MG Unresponsive to pyridostigmine Recent onset only (< 5 yrs) From a poll of 56 neurologists on the Med Adv Board of the MGF (Lanska 1990) Neuro-ophthalmic Consultants Northwest .
26% no change. J Thorac Cardiovasc Surg 2001.Thymectomy for Ocular MG • Roberts et al.122:562-8 – 61 patients with Ocular MG only underwent thymectomy – Mean follow-up of 9 years – 12 patients received anticholinesterase and steroids – 51% cured. 20% improvement. 3% worsening – 70% were cured or improved post thymectomy Neuro-ophthalmic Consultants Northwest .
Conclusions • Ocular MG can usually be accurately diagnosed in patients presenting with diplopia and/or ptosis • Ocular MG has a high spontaneous rate of conversion to generalized MG over 3 years • There are strong immunological reasons to seriously consider early immunosuppression of ocular MG to optimize the patient's quality of life and prevent long-term generalization and disability Neuro-ophthalmic Consultants Northwest .
Utah Neuro-ophthalmic Consultants Northwest .Bryce Canyon.
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- Dressing Room
- Towels
- Free toiletries
- Hairdryer
- Toilet paper
- Linen
Living Area
- Dining area
- Seating Area
Media & Technology
- Flat-screen TV
- Cable Channels
Room Amenities
- Iron
- Hardwood/Parquet floors
Pets are not allowed.
- Upper floors accessible by lift
Building characteristics
- Private flat in building
Outdoor & View
- City view
- Heating
- Lift
- Family rooms
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Property surroundings – This neighbourhood is a great choice for travellers interested in shopping, art, and city walks – Check location Great location - show map
Closest landmarks
- Le Peletier Metro Station 0.1 miles
- Notre-Dame-de-Lorette Metro Station 0.2 miles
- Cadet Metro Station 0.2 miles
- Folies Bergère 0.2 miles
- Richelieu Drouot Metro Station 0.2 miles
Most popular landmarks
- Sacré-Coeur 0.9 miles
- Louvre Museum 1 miles
- Notre Dame Cathedral 1.6 miles
- Opéra Bastille 2.1 miles
- Arc de Triomphe 2.1 miles
From 15:00 hours
11:00 - 12:00 hours
Cancellation and prepayment policies vary according to apartment type. Please enter the dates of your stay and check the conditions of your required room.
Children and extra beds
All children are welcome.
There is no capacity for extra beds in the room.
Pets are not allowed.
Cash only
Booking.com takes your payment on behalf of the property for this stay, but make sure you have cash for any extras once you get there.
A security deposit of EUR 345 is required upon arrival for incidentals. This deposit is fully refundable upon check-out and subject to a damage inspection of the accommodation.
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